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Sample records for action program rap

  1. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  2. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  3. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  4. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  5. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  6. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  7. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  8. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  9. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  10. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  11. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  12. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  13. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  14. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  15. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  16. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  17. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  18. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  19. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  20. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  1. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  2. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  3. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  4. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  5. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  6. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  7. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  8. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  9. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  10. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  11. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  12. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  13. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  14. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  15. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  16. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  17. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  18. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  19. Region 1: Radiological Assistance Program (RAP). Revision 2, Part 1

    SciTech Connect

    Hull, A.P.; Kuehner, A.V.

    1993-10-01

    The Department of Energy`s Radiological Assistance Program (RAP) is established under DOE Order 5530.3 to: (a) Establish and maintain response plans and resources to provide radiological assistance to other Federal agencies, State, local, and tribal governments, and private groups requesting such assistance. (b) Assist State, local, and tribal jurisdictions in preparing for radiological emergencies. (c) In the event of a real, or potential radiological accident, provide resources and monitoring and assessment assistance to other federal agencies, State, local, and tribal Governments. This plan is an integral part of a nationwide program of regionally based radiological assistance which has been established by DOE. The Brookhaven Area Office is the Regional Coordinating Office (RCO) for the Radiological Assistance Program in DOE Region 1, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia.

  20. Hazardous Waste Remedial Actions Program: Remedial Actions Planning Program Quality Assurance Program Plan

    SciTech Connect

    Not Available

    1989-04-01

    The purpose of this Plan is to describe the quality assurance (QA) requirements for the RAP Program by identifying the quality elements to be controlled and specifying how they will be controlled. The activities for which control elements will be identified include those relating to: preparation, review, and approval of plans, reports, and studies; execution of field and analytical work by subcontractors and other agents; control of subcontractors and other agents during other phases of work; and actions internal to the RAP Program to ensure proper execution of projects.

  1. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  2. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  3. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  4. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  5. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  6. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  7. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  8. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  9. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  10. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  11. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  12. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  13. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  14. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  15. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  16. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  17. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  18. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  19. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  20. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  1. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  2. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  3. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  4. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  5. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  6. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  7. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  8. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  9. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  10. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  11. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  12. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  13. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  14. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  15. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  16. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  17. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  18. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  19. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  20. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  1. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  2. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  3. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  4. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  5. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  6. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  7. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  8. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  9. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  10. Partnering for environmental restoration: The Port Hope Harbour Remedial Action Plan (RAP)

    SciTech Connect

    Weston, S.M.C.

    1995-12-31

    A Remedial Action Plan (RAP) is being developed for Port Hope Harbour, one of 43 Areas of Concern (AOCs) identified by the International Joint Commission (IJC). The RAP, when implemented, will lead to the restoration and protection of desirable water conditions in Port Hope Harbour. The environmental concern associated with the harbor can be best viewed as a historical contaminated sediment problem. Approximately 90,000 m{sup 3} of sediment located in Port Hope Harbour`s turning basin and west slip are contaminated by uranium and thorium series radionuclides, heavy metals, and PCBs. There are several groups contributing to the development of the RAP. All of these groups have the common goal of developing an environmentally sound plan that reflects the views of the community. Strategic partnerships have been established that recognize the need to integrate and coordinate the efforts of all agencies, stakeholders, and the community. The objective is to develop an environmentally sound remediation plan through an efficient and effective management framework.

  11. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  12. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  13. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  14. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  15. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  16. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  17. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  18. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  19. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  20. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  1. Reinforcing Alcohol Prevention (RAP) Program: A Secondary School Curriculum to Combat Underage Drinking and Impaired Driving

    ERIC Educational Resources Information Center

    Will, Kelli England; Sabo, Cynthia Shier

    2010-01-01

    The Reinforcing Alcohol Prevention (RAP) Program is an alcohol prevention curriculum developed in partnership with secondary schools to serve their need for a brief, evidence-based, and straightforward program that aligned with state learning objectives. Program components included an educational lesson, video, and interactive activities delivered…

  2. Operation Storefront. A Computer-Assisted Instruction Component of the Reading Assistance Program (RAP).

    ERIC Educational Resources Information Center

    Pasco County District School Board, Land O'Lakes, FL.

    This document contains teacher's materials that accompany Operation Storefront, the computer-assisted instruction package used in the Reading Assistance Program (RAP) that serves nonreading adults in Pasco County, Florida, who are 16 years or older and not in school. The target population for Operation Storefront is adults reading at or below the…

  3. Total quality management -- Remedial actions planning program

    SciTech Connect

    Petty, J.L.; Horne, T.E.

    1989-01-01

    This paper describes the management approach being taken within the Hazardous Waste Remedial Actions Program (HAZWRAP) Support Contractor Office (SCO) to ensure quality of services in a highly competitive waste management environment. An overview is presented of the contractor support role assigned to Martin Marietta Energy Systems, Inc., by the Department of Energy (DOE) national program for managing hazardous waste. The HAZWRAP SCO mission, organizational structure, and major programs are outlined, with emphasis on waste management planning for the DOE Work for Others (WFO) Program. The HAZWRAP SCO provides waste management technical support, via interagency agreements between DOE and various Department of Defense (DOD) agencies for DOD sponsors planning remedial response actions. The remainder of the paper focuses on how the concept of Total Quality Management is applied to the HAZWRAP Remedial Actions Planning (RAP) Program. The management challenge is to achieve quality on a ''system'' basis where all functional elements of program management synergistically contribute to the total quality of the effort. The quality assurance (QA) program requirements applied to the RAP Program and its subcontractors are discussed. The application of management principles in the areas of program management, procurement, and QA to achieve total quality is presented. 3 refs.

  4. An Action Research Study on the Influence of Gangsta Rap on Academic and Behavioral Issues of 5th Grade African-American Males

    ERIC Educational Resources Information Center

    Lewis, Shaun; Boes, Susan R.; Chibbaro, Julie S.

    2015-01-01

    This small action research study (ARS) began with a review of the literature examining the relationship of gangsta rap in regards to academic achievement, self-esteem, decision-making, identity issues and development of young African American males. The purpose of the ARS was to examine the correlation between gangsta rap and its influence on 5th…

  5. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  6. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  7. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  8. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  9. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  10. A demonstration of the applicability of implementing the enhanced Remedial Action Priority System (RAPS) for environmental releases

    SciTech Connect

    Whelan, G.; Droppo, J.G. Jr.; Strenge, D.L.; Walter, M.B.; Buck, J.W.

    1989-12-01

    The Remedial Action Priority System (RAPS) and the Multimedia Environmental Pollutant Assessment System (MEPAS) were developed to prioritize problems associated with potential releases of hazardous chemical and radioactive materials in a scientific and objective manner based on limited site information. This report documents the model testing efforts of the RAPS/MEPAS methodology for the atmospheric, surface water, groundwater, and exposure components. Comparisons are given of model outputs with measured data at three sites: the US Department of Energy's Mound facility in Ohio and Hanford facility in Washington, and a chromium-cadmium plating site in New York. The results show that the simulated magnitudes, spacial and temporal trends, and distributions of contaminants corresponded well with the measured data. 25 refs., 86 figs., 26 tabs.

  11. Television Programming: The "Boob Tube" Takes a Bum Rap

    ERIC Educational Resources Information Center

    Baird, John E., Jr.

    1976-01-01

    Attempts to test objectively one of the most prominent criticisms--that television programming is imitative and restrictive of viewer choice--in an effort to determine whether that criticism is legitimate. (Author/RK)

  12. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.

    PubMed

    Kaneko, Kentaro; Xu, Pingwen; Cordonier, Elizabeth L; Chen, Siyu S; Ng, Amy; Xu, Yong; Morozov, Alexei; Fukuda, Makoto

    2016-09-13

    The CNS contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here, we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in high-fat diet (HFD)-induced obesity. Genetic ablation of CNS Rap1 protects mice from dietary obesity, glucose imbalance, and insulin resistance in the periphery and from HFD-induced neuropathological changes in the hypothalamus, including diminished cellular leptin sensitivity and increased endoplasmic reticulum (ER) stress and inflammation. Furthermore, pharmacological inhibition of CNS Rap1 signaling normalizes hypothalamic ER stress and inflammation, improves cellular leptin sensitivity, and reduces body weight in mice with dietary obesity. We also demonstrate that Rap1 mediates leptin resistance via interplay with ER stress. Thus, neuronal Rap1 critically regulates leptin sensitivity and mediates HFD-induced obesity and hypothalamic pathology and may represent a potential therapeutic target for obesity treatment. PMID:27626668

  13. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Central Nervous System (CNS) contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here, we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in...

  14. Data base management activities for the Remedial Action Program at ORNL, calendar year 1987

    SciTech Connect

    Voorhees, L.D.; Hook, L.A.; Gentry, M.J.; McCord, R.A.; Faulkner, M.A.; Newman, K.A.; Owen, P.T.

    1988-05-01

    The Oak Ridge National Laboratory (ORNL) Remedial Action Program (RAP) was established in FY 1985 to apply corrective measures at areas contaminated with radioactive and/or hazardous chemical wastes. To achieve this goal, numerous and varied studies are being conducted to characterize the waste disposal sites. Environmental data collected in support of other programs at ORNL are also of use to RAP. These studies are generating a voluminous amount of data on a scale unprecedented for ORNL. A computerized Data and Information Management System (DIMS) was developed for RAP to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated facilities and sites. 10 refs., 25 figs., 16 tabs.

  15. Data base management activities for the Remedial Action Program at ORNL: Calendar year 1988

    SciTech Connect

    Voorhees, L.D.; Hook, L.A.; Gentry, M.J.; McCord, R.A.; Faulkner, M.A.; Bledsoe, J.L.; Newman, K.A.; Owen, P.T.; Rosen, A.E.

    1989-04-01

    The ORNL Remedial Action Program (RAP) was established in 1985 in response to state and federal regulations mandating corrective actions at contaminated sites. To achieve this goal, numerous and varied studies are being conducted to characterize the type and extent of contamination. Environmental data collected in support of other programs at ORNL are also of use to RAP. Collectively, these studies are generating a voluminous amount of data. A computerized Data and Information Management System (DIMS) was developed for RAP to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated facilities and sites. The current DIMS and its role in supporting RAP during 1988 are described. The DIMS consists of three components: (1) the Numeric Data Base, (2) the Bibliographic Data Base, and (3) the Records Control Data Base. This report addresses all three data bases, but focuses on a description of the contents of the Numeric Data Base. The types of numeric data currently available are summarized in the tables and figures. More detailed information on the contents of the RAP Numeric Data Base has been assembled in a menu-driven format on IBM PC diskettes, which are available upon request. 6 refs.

  16. Rap-Music Attitude and Perception Scale: A Validation Study

    ERIC Educational Resources Information Center

    Tyson, Edgar H.

    2006-01-01

    Objective: This study tests the validity of the Rap-music Attitude and Perception (RAP) Scale, a 1-page, 24-item measure of a person's thoughts and feelings surrounding the effects and content of rap music. The RAP was designed as a rapid assessment instrument for youth programs and practitioners using rap music and hip hop culture in their work…

  17. Programs for Urban Action.

    ERIC Educational Resources Information Center

    National Board of Young Men's Christian Associations, New York, NY.

    This booklet contains descriptions of 150 urban action programs being conducted by Young Men's Christian Associations throughout the United States. Planning principles are included to assist those who wish to adapt the programs to local situations: involvement of people in planning; use of local indigenous leadership; planning in collaboration…

  18. Data and Information Management System for the ORNL Remedial Action Program

    SciTech Connect

    Voorhees, L.D.; Hook, L.A.; Gentry, M.J.; Owen, P.T.; Newman, K.A.; McCord, R.A.; Faulkner, M.A.; Bledsoe, J.L.

    1988-01-01

    A Remedial Action Program (RAP) was established in FY 1985 at Oak Ridge National Laboratory (ORNL) to provide corrective measures at areas contaminated with radioactive and/or hazardous chemical wastes. To achieve this goal, numerous and varied studies are being conducted to characterize the waste disposal sites. Environmental data collected in support of other programs at ORNL are also of use to RAP. Collectively, these studies are generating a voluminous amount of data on a scale unprecedented for ORNL. A computerized Data and Information Management System (DIMS) was developed to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated sites and facilities. The current DIMS and its role in supporting RAP are described. The DIMS consists of three components: (1) the Bibliographic Data Base, (2) the Records Control Data Base, and (3) the Numeric Data Base. This paper/poster emphasizes the Numeric Data Base, including its development and organization, and also summarizes the status of other activities associated with management and use of such data (i.e., bibliographic information, records control, geographic information, and quality assurance). The types of data currently available have been summarized, and a synopsis of the contents of the RAP numeric data base has been compiled in a menu-driven program available on PC diskettes. The synopsis will be demonstrated at the conference. 4 refs., 5 figs.

  19. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false How may I renew my RAP if it is... Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.200 How may I renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  20. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  1. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  2. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false How may I renew my RAP if it is... Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.200 How may I renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  3. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  4. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  5. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  6. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  7. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  8. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  9. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  10. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false How may I renew my RAP if it is... Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.200 How may I renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  11. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  12. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  13. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  14. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  15. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  16. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  17. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  18. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  19. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  20. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  1. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  2. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false How may I renew my RAP if it is... Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.200 How may I renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  3. COMMUNITY ACTION PROGRAMS REPORT.

    ERIC Educational Resources Information Center

    MACDOUGALL, MARY ANN

    SPECIAL PROGRAMS IN REMEDIAL READING, EARLY CHILDHOOD EDUCATION, SUMMER SCHOOL INSTRUCTION, AND SCHOOL-COMMUNITY COORDINATION ARE EVALUATED. ALTHOUGH THE REMEDIAL READING PROGRAM DID NOT ESTABLISH THE SUPERIORITY OF ANY PARTICULAR METHOD OF TEACHING, IT DEMONSTRATED THE VALUE OF HAVING A READING SPECIALIST ON THE SCHOOL STAFF. MOST 4-YEAR-OLD…

  4. Data base management activities for the Remedial Action Program at Oak Ridge National Laboratories (ORNL)

    SciTech Connect

    Hook, L.A.; Voorhees, L.D.; Gentry, M.J.; Faulkner, M.A.; Shaakir-Ali, J.A.; Newman, K.A.; McCord, R.A.; Goins, L.F.; Owen, P.T.

    1990-07-01

    The Oak Ridge National Laboratory (ORNL) Remedial Action Program (RAP) was established in 1985 in response to state and federal regulations requiring comprehensive control over facility discharges and cleanup of contaminated sites. A computerized Data and Information Management System (DIMS) was developed for RAP to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated facilities and sites. The current status of DIMS and its role in supporting RAP during 1989 are described. The DIMS consists of three components: (1) the Numeric Data Base, (2) the Bibliographic Data Base, and (3) the Records Control Data Base. This report addresses all three data bases, but focuses on the contents of the Numeric Data Base. Significant progress was made last year with the geographic information system (GIS) and ARC/INFO, which can be interfaced with SAS/GRAPH to provide combined mapping and statistical graphic products. Several thematic layers of GIS data for the Oak Ridge Reservation are now available. 18 refs., 8 figs., 19 tabs.

  5. ORNL Remedial Action Program strategy (FY 1987-FY 1992)

    SciTech Connect

    Trabalka, J.R.; Myrick, T.E.

    1987-12-01

    Over 40 years of Oak Ridge National Laboratory (ORNL) operations have produced a diverse legacy of contaminated inactive facilities, research areas, and waste disposal areas that are potential candidates for remedial action. The ORNL Remedial Action Program (RAP) represents a comprehensive effort to meet new regulatory requirements and ensure adequate protection of on-site workers, the public, and the environment by providing appropriate corrective measures at over 130 sites contaminated historically with radioactive, hazardous chemical, or mixed wastes. A structured path of program planning, site characterization, alternatives assessment, technology development, engineering design, continued site maintenance and surveillance, interim corrective action, and eventual site closure or decommissioning is required to meet these objectives. This report documents the development of the Remedial Action Program, through its preliminary characterization, regulatory interface, and strategy development activities. It provides recommendations for a comprehensive, long-term strategy consistent with existing technical, institutional, and regulatory information, along with a six-year plan for achieving its initial objectives. 53 refs., 8 figs., 12 tabs.

  6. System 80+ D-RAP, a communication tool

    SciTech Connect

    Siegmann, E.R.; Mody, A.A.

    1994-12-31

    The purpose of {open_quotes}RAP{close_quotes} music is to communicate, and the purpose of D-RAP is to foster communication between the probabilistic risk assessment (PRA) group, designers, and the future combined operating license (COL) applicant. This is to ensure that the design is self-consistent and integrated with the procurement process. The designer reliability assurance program (D-RAP) is the first part of the RAP. The goals of the D-RAP are to have risk-significant systems, structures, and components (SSCs) identified and considered in the detail design and procurement phases and to maintain consistency between PRA and design. Plant safety is maintained throughout the design phase, and pertinent information is passed on to the COL applicant. The operations RAP (O-RAP) covers the plant operation and maintenance.

  7. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  8. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  9. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  10. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  11. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  12. Structural basis of Rap phosphatase inhibition by Phr peptides.

    PubMed

    Gallego del Sol, Francisca; Marina, Alberto

    2013-01-01

    Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation, by inhibiting the RR components involved in these pathways. Despite the high degree of sequence homology, Rap proteins exert their activity by two completely different mechanisms of action: inducing RR dephosphorylation or blocking RR binding to its target promoter. However the regulatory mechanism involving Rap proteins is even more complex since Rap activity is antagonized by specific signaling peptides (Phr) through a mechanism that remains unknown at the molecular level. Using X-ray analyses, we determined the structure of RapF, the anti-activator of competence RR ComA, alone and in complex with its regulatory peptide PhrF. The structural and functional data presented herein reveal that peptide PhrF blocks the RapF-ComA interaction through an allosteric mechanism. PhrF accommodates in the C-terminal tetratricopeptide repeat domain of RapF by inducing its constriction, a conformational change propagated by a pronounced rotation to the N-terminal ComA-binding domain. This movement partially disrupts the ComA binding site by triggering the ComA disassociation, whose interaction with RapF is also sterically impaired in the PhrF-induced conformation of RapF. Sequence analyses of the Rap proteins, guided by the RapF-PhrF structure, unveil the molecular basis of Phr recognition and discrimination, allowing us to relax the Phr specificity of RapF by a single residue change.

  13. BSE Rap: intergenerational ties to save lives.

    PubMed

    Ehmann, J L

    1993-09-01

    This article presents an innovative public-education strategy that was created to promote breast health awareness and early breast cancer detection among minority and low-income adolescent females. Given the importance of teaching breast self-examination (BSE), program development focused on creation of the BSE Rap, a lively music-video presentation. Increasing adolescents' knowledge and awareness of BSE is viewed as a springboard for disseminating information to their mothers and grandmothers. Funding was obtained for production of a video and a breast health diary, which are the program's key components. Marketing strategies included contacts with community organizations and healthcare professionals. Program evaluations reveal that the BSE Rap serves as a positive motivator for participants to discuss BSE and mammography with their mothers and grandmothers. The BSE Rap offers oncology nurses the opportunity to save lives using a unique and creative tool that focuses on intergenerational ties. PMID:8415152

  14. Lawrence Berkeley Laboratory Affirmative Action Program. Revised

    SciTech Connect

    1995-06-01

    The Lawrence Berkeley Laboratory`s Affirmative Action Program (AAP) serves as a working document that describes current policies, practices, and results in the area of affirmative action. It represents the Laboratory`s framework for an affirmative approach to increasing the representation of people of color and women in segments of our work force where they have been underrepresented and taking action to increase the employment of persons with disabilities and special disabled and Vietnam era veterans. The AAP describes the hierarchy of responsibility for Laboratory affirmative action, the mechanisms that exist for full Laboratory participation in the AAP, the policies and procedures governing recruitment at all levels, the Laboratory`s plan for monitoring, reporting, and evaluating affirmative action progress, and a description of special affirmative action programs and plans the Laboratory has used and will use in its efforts to increase the representation and retention of groups historically underrepresented in our work force.

  15. Library Programs. LSCA Programs: An Action Report.

    ERIC Educational Resources Information Center

    Office of Educational Research and Improvement (ED), Washington, DC.

    The seven narrative reports featured in this publication detail the accomplishments, in seven key areas, of State Grant Programs (Titles I, II, and III) funded by the Library Services and Construction Act (LSCA). These descriptions of state and local library activities, demonstrating how libraries are meeting a variety of users' needs, are: (1)…

  16. Creative Technology and Rap

    ERIC Educational Resources Information Center

    Ch'ien, Evelyn

    2011-01-01

    This paper describes how a linguistic form, rap, can evolve in tandem with technological advances and manifest human-machine creativity. Rather than assuming that the interplay between machines and technology makes humans robotic or machine-like, the paper explores how the pressure of executing artistic visions using technology can drive…

  17. Squaring to the Rap!

    ERIC Educational Resources Information Center

    Adams, Deborah

    2006-01-01

    This article describes an approach to teaching square dance that is advantageous for both the teacher and students. Lessons in dance become more meaningful to students when the music and vocabulary is consistent with experiences in their own lives. When students create their own squaring to the rap, lessons become more student-centered,…

  18. RCRA corrective action program guide (Interim)

    SciTech Connect

    Not Available

    1993-05-01

    The US Department of Energy (DOE) is responsible for compliance with an increasingly complex spectrum of environmental regulations. One of the most complex programs is the corrective action program proposed by the US Environmental Protection Agency (EPA) under the authority of the Resource Conservation and Recovery Act (RCRA) as amended by the Hazardous and Solid Waste Amendments (HSWA). The proposed regulations were published on July 27, 1990. The proposed Subpart S rule creates a comprehensive program for investigating and remediating releases of hazardous wastes and hazardous waste constituents from solid waste management units (SWMUs) at facilities permitted to treat, store, or dispose of hazardous wastes. This proposed rule directly impacts many DOE facilities which conduct such activities. This guidance document explains the entire RCRA Corrective Action process as outlined by the proposed Subpart S rule, and provides guidance intended to assist those persons responsible for implementing RCRA Corrective Action at DOE facilities.

  19. Elementary Career Intervention Programs: Social Action Initiatives

    ERIC Educational Resources Information Center

    Palladino Schultheiss, Donna E.

    2005-01-01

    This paper examines several conceptual frameworks that can inform elementary career intervention programming. Equity, social justice, and the development of intrinsic motivation are key concepts in the promotion of social action initiatives aimed at improving academic achievement and expanding future career options for all students. Early career…

  20. Environmental Educational Youth Action Task Program

    ERIC Educational Resources Information Center

    Ab Rahman, Nik Norulaini Nik; Omar, Fatehah Mohd; Kalia, Noorliza; Hasmi, Mohammad

    2008-01-01

    An educational environmental youth camp was held comprising of fifty one 16-year old secondary students and facilitated by volunteers from the university and Friends of the Earth, a non profit organization in Penang. A weekend camp on youth action task program was held at an isolated beach packed with activities that were structured towards…

  1. Service Learning: An Action Oriented Program Evaluation

    ERIC Educational Resources Information Center

    Kelley, George

    2013-01-01

    Service learning is an academic discipline that provides students with "hands-on" opportunities for developing skills in real-world, community-based projects that serve and benefit community members. This dissertation reflects an action-oriented process for improving the quality of the Service Learning Program at City University of…

  2. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... instead of doing the work within the community's own planning agencies. (4) Applications for RAP grants need a full 60 day A-95 clearinghouse review. Clearinghouse comments for RAP grants must then be submitted to NPS. Final RAP's also must be submitted to clearinghouses, in accordance with OMB Circular A-95....

  3. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... instead of doing the work within the community's own planning agencies. (4) Applications for RAP grants need a full 60 day A-95 clearinghouse review. Clearinghouse comments for RAP grants must then be submitted to NPS. Final RAP's also must be submitted to clearinghouses, in accordance with OMB Circular A-95....

  4. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... instead of doing the work within the community's own planning agencies. (4) Applications for RAP grants need a full 60 day A-95 clearinghouse review. Clearinghouse comments for RAP grants must then be submitted to NPS. Final RAP's also must be submitted to clearinghouses, in accordance with OMB Circular A-95....

  5. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... instead of doing the work within the community's own planning agencies. (4) Applications for RAP grants need a full 60 day A-95 clearinghouse review. Clearinghouse comments for RAP grants must then be submitted to NPS. Final RAP's also must be submitted to clearinghouses, in accordance with OMB Circular A-95....

  6. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... program components. The local government will submit an Action Program which documents the recreation... park and recreation system. The local government must develop the Action Program consistent with and... expressed in its comprehensive plans and other documents. The Action Program consists of two sections...

  7. YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.

    PubMed

    Schmid, Rainer; Meyer, Katharina; Spang, Rainer; Schittek, Birgit; Bosserhoff, Anja Katrin

    2013-01-01

    MIA/CD-RAP is a small, secreted protein involved in cartilage differentiation and melanoma progression. We recently revealed that p54(nrb) acts as a mediator of MIA/CD-RAP action to promote chondrogenesis and the progression of malignant melanoma. As the molecular mechanism of MIA/CD-RAP action in cartilage has not been defined in detail until now, we aimed to understand the regulation of p54(nrb) transcription in chondrogenesis. We concentrated on the previously described MIA/CD-RAP-dependent regulatory region in the p54(nrb) promoter and characterized the transcriptional regulation of p54(nrb) by MIA/CD-RAP in cartilage. A series of truncated p54(nrb) promoter constructs and mutagenesis analysis revealed that the transcription factor YBX1, which has not been investigated in chondrogenesis thus far, is the mediator of MIA/CD-RAP dependent activation of p54(nrb) transcription. A systematic analysis of genes carrying this binding site in their promoter region revealed further potential MIA/CD-RAP-regulated genes that have been implicated in cartilage differentiation. In summary, we described the effects of MIA/CD-RAP on transcriptional regulation in chondrocytes. Understanding the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis. Uncovering new downstream effectors that function via the activation of YBX1 supports the important role of MIA/CD-RAP in these processes.

  8. Plk2 Raps up Ras to subdue synapses

    PubMed Central

    Lee, Kea Joo; Hoe, Hyang-Sook

    2011-01-01

    We recently identified the activity-inducible protein kinase Plk2 as a novel overseer of the balance between Ras and Rap small GTPases. Plk2 achieves a profound level of regulatory control by interacting with and phosphorylating at least four Ras and Rap guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Combined, these actions result in synergistic suppression of Ras and hyperstimulation of Rap signaling. Perturbation of Plk2 function abolished homeostatic adaptation of synapses to enhanced activity and impaired behavioral adaptation in various learning tasks, indicating that this regulation was critical for maintaining appropriate Ras/Rap levels. These studies provide insights into the highly cooperative nature of Ras and Rap regulation in neurons. However, different GEF and GAP substrates of Plk2 also controlled specific aspects of dendritic spine morphology, illustrating the ability of individual GAPs/GEFs to assemble microdomains of Ras and Rap signaling that respond to different stimuli and couple to distinct output pathways. PMID:21776418

  9. 48 CFR 422.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Affirmative action programs. 422.804 Section 422.804 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Affirmative action programs....

  10. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  11. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC... Affirmative action programs....

  12. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  13. 48 CFR 1522.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Affirmative action programs. 1522.804 Section 1522.804 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY....804 Affirmative action programs....

  14. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  15. 48 CFR 1422.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Affirmative action programs. 1422.804 Section 1422.804 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR....804 Affirmative action programs....

  16. 48 CFR 1422.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Affirmative action programs. 1422.804 Section 1422.804 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR....804 Affirmative action programs....

  17. 48 CFR 422.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Affirmative action programs. 422.804 Section 422.804 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Affirmative action programs....

  18. 48 CFR 22.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs....

  19. 48 CFR 22.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs....

  20. 48 CFR 22.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs....

  1. 48 CFR 1422.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Affirmative action programs. 1422.804 Section 1422.804 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR....804 Affirmative action programs....

  2. 48 CFR 22.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs....

  3. 48 CFR 1522.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Affirmative action programs. 1522.804 Section 1522.804 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY....804 Affirmative action programs....

  4. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC... Affirmative action programs....

  5. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC... Affirmative action programs....

  6. 48 CFR 422.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Affirmative action programs. 422.804 Section 422.804 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Affirmative action programs....

  7. 48 CFR 22.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Affirmative action programs. 22.804 Section 22.804 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Affirmative action programs....

  8. 48 CFR 422.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Affirmative action programs. 422.804 Section 422.804 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Affirmative action programs....

  9. 48 CFR 1522.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Affirmative action programs. 1522.804 Section 1522.804 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY....804 Affirmative action programs....

  10. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  11. 48 CFR 422.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Affirmative action programs. 422.804 Section 422.804 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE... Affirmative action programs....

  12. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  13. 48 CFR 1522.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Affirmative action programs. 1522.804 Section 1522.804 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY....804 Affirmative action programs....

  14. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary Action Program requirements. The following information must be submitted: (a) Evidence of...

  15. Annual status report on the Uranium Mill Tailings Remedial Action Program

    SciTech Connect

    Not Available

    1985-12-01

    FY 1985 project accomplishments include: completed 90% of the processing site remedial actions at Canonsburg, Pennsylvania, and initiated remedial actions at Salt Lake City, Utah, and Shiprock, New Mexico; awarded remedial action contracts on 329 vicinity properties at seven designated locations and completed survey and inclusion activities on a total of 1620 vicinity properties; published the Environmental Assessment (EA) for Lakeview, Oregon, issued the draft and prepared the final Environmental Impact Statement (EIS) for Durango, Colorado; completed the Remedial Action Plan (RAP) for Lakeview, Oregon, and prepared the draft RAP for Durango, Colorado; executed cooperative agreements with Idaho, New Mexico, and the Navajo Nation/Hopi Tribe; executed a Memorandum of Understanding with the Nuclear Regulatory Commission; and developed proposed UMTRA Project design review criteria between DOE and the NRC.

  16. Active Sites Environmental Monitoring Program: Action levels

    SciTech Connect

    Ashwood, J.S.; Ashwood, T.L.

    1991-10-01

    The Active Sites Environmental Monitoring Program (ASEMP) was established at Oak Ridge National Laboratory to provide for early leak detection and to monitor performance of the active low-level waste disposal facilities in Solid Waste Storage Area (SWSA) 6 and the transuranic waste storage areas in SWSA 5 North. Early leak detection is accomplished by sampling runoff, groundwater, and perched water in burial trenches. Sample results are compared to action levels that represent background contamination by naturally occurring and fallout-derived radionuclides. 15 refs., 3 figs., 12 tabs.

  17. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) copies of the Preliminary Action Program. (Sec. 1007(a) and (b) of Title X National Parks and Recreation... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  18. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) copies of the Preliminary Action Program. (Sec. 1007(a) and (b) of Title X National Parks and Recreation... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  19. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) copies of the Preliminary Action Program. (Sec. 1007(a) and (b) of Title X National Parks and Recreation... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  20. Translation of the Risk Avoidance Partnership (RAP) for Implementation in Outpatient Drug Treatment Clinics.

    PubMed

    Weeks, Margaret R; Kostick, Kristin; Li, Jianghong; Dunn, Jennifer; McLaughlin, Paul; Richmond, Phil; Choudhury, Shonali; Obidoa, Chinekwu; Mosher, Heather; Martinez, Maria

    2015-01-01

    Scientific literature increasingly calls for studies to translate evidence-based interventions into real-world contexts balancing fidelity to the original design and fit to the new setting. The Risk Avoidance Partnership (RAP) is a health promotion intervention originally designed to train active drug users to become Peer Health Advocates. A theoretically driven approach was used to adapt RAP to fit implementation in outpatient methadone treatment clinics and pilot it with clinic patients. Ethnographic observations and process tracking documented the RAP translation and pilot experience, and clinic and community characteristics relevant to program implementation. Clinic administrators, staff, and patients were interviewed on their values, capacities, interest in RAP, perceived challenges of implementing RAP in drug treatment clinics, and experiences during the pilot. Findings indicated that RAP core components can be met when implemented in these settings and RAP can fit with the goals, interests, and other programs of the clinic. Balancing fidelity and fit requires recognition of the mutual impacts RAP and the clinic have on each other, which generate new interactions among staff and require ongoing specification of RAP to keep abreast of clinic and community changes. Collaboration of multiple stakeholders significantly benefited translation and pilot processes.

  1. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra.

    PubMed

    Guo, Xiao-Xi; An, Su; Yang, Yang; Liu, Ying; Hao, Qian; Xu, Tian-Rui

    2016-01-01

    Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy.

  2. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra.

    PubMed

    Guo, Xiao-Xi; An, Su; Yang, Yang; Liu, Ying; Hao, Qian; Xu, Tian-Rui

    2016-01-01

    Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy. PMID:27322838

  3. Hanford Tank Farm RCRA Corrective Action Program

    SciTech Connect

    Kristofzski, J.R.; Mann, F.M.; Anderson, F.J.; Lober, R.W.

    2007-07-01

    As a consequence of producing special nuclear material for the nation's defense, large amounts of extremely hazardous radioactive waste was created at the U.S. Department of Energy's (DOE) Hanford Site in south central Washington State. A little over 50 million gallons of this waste is now stored in 177 large, underground tanks on Hanford's Central Plateau in tank farms regulated under the Atomic Energy Act and the Resource, Conservation, and Recovery Act (RCRA). Over 60 tanks and associated infrastructure have released or are presumed to have released waste in the vadose zone. In 1998, DOE's Office of River Protection established the Hanford Tank Farm RCRA Corrective Action Program (RCAP) to: - Characterize the distribution and extent of the existing vadose zone contamination; - Determine how the contamination will move in the future; - Estimate the impacts of this contamination on groundwater and other media; - Develop and implement mitigative measures; - Develop corrective measures to be implemented as part of the final closure of the tank farm facilities. Since its creation, RCAP has made major advances in each of these areas, which will be discussed in this paper. (authors)

  4. Institutional frameworks to direct development and implementation of great lakes remedial action plans

    NASA Astrophysics Data System (ADS)

    Hartig, John H.; Law, Neely

    1994-11-01

    Locally designed, institutional frameworks are being used to develop and implement remedial action plans (RAPs) to restore beneficial uses in 43 Great Lakes areas of concern. A 1993 Canada-United States roundtable was convened to learn from case studies and to develop recommendations regarding essential characteristics of RAP institutional frameworks, guidance to ensure linkages to other related plans, and ways of embracing new institutional frameworks from RAP development to implementation. Major roundtable recommendations are: (1) RAP institutional frameworks should be empowered to pursue their mission of restoring uses. Empowerment would be demonstrated by: a watershed focus, inclusive and shared decision-making, clear responsibilities and sufficient authority, creative funding capability, flexibility and continuity in the process, an iterative process of continuous improvement, and commitment to education and outreach. (2) RAP institutional frameworks should be used as mechanisms to coordinate programs at the local level. Such local coordination should be complemented with governmental commitments to intra- and interagency coordination in work plans. (3) RAP institutional frameworks can help build the capacity of governments to achieve their goals. Therefore, governments must adopt long-term, visionary goals and commit to a customer-driven RAP process of continuous improvement.

  5. German Rap Music in the Classroom.

    ERIC Educational Resources Information Center

    Schmidt, Johannes

    2003-01-01

    Provides background information on German rap artists and bands and discusses how to implement the music in various classroom situations at all levels. Highlights some of the available material on German rap music and provides information on how to locate rap texts, information, and other material via the Internet and other sources. (Author/VWL)

  6. Action Research in EdD Programs in Educational Leadership

    ERIC Educational Resources Information Center

    Osterman, Karen; Furman, Gail; Sernak, Kathleen

    2014-01-01

    This exploratory study gathered information about the use of action research within doctor of education programs in educational leadership and explored faculty understanding of and perspectives on action research. Survey data established that action research is used infrequently to meet dissertation requirements. Contributing factors include lack…

  7. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Action program components. 72.11 Section 72.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.11...

  8. Technology Education in Action: Outstanding Programs.

    ERIC Educational Resources Information Center

    International Technology Education Association, Reston, VA.

    This volume contains 10 articles describing middle school and high school technology education programs conducted in schools throughout the United States. Program descriptions, which are written by the teachers involved in the programs, are from schools in the following areas: Ann Arbor, Michigan; Chicago, Illinois; Pittsburg, Kansas; Salt Lake…

  9. Affirmative Action Compliance Program for Fiscal Year 1980

    SciTech Connect

    Not Available

    1980-01-01

    Eleven chapters are used to delineate Lawrence Berkeley Lab's compliance, namely: (1) a description of LBL's facility, history, staff, mission, etc; (2) Affirmative Action policy statement; (3) dissemination (internal and external) per the implementation regulations; (4) identification of Affirmative Action responsibilities; (5) personnel policies; (6) past goal-setting process and accomplishment; (7) work-force array, job groups, availability determinations, identification of underutilization, and goals and timetables; (8) identification of problem areas and action-oriented programs; (9) listing and brief description of specific LBL Affirmative Action programs; (10) compliance with sex-discrimination guidelines; and (11) compliance with guidelines on discrimination because of religion or national origin.

  10. Affirmative Action Programs: A Current Perspective.

    ERIC Educational Resources Information Center

    Muhammad, Habibah P.

    Recent lawsuits and judgments brought against colleges and universities for enacting affirmative action policies are threatening to dismantle the core principles of the Bakke decision (Regents of the University of California v. Bakke) and undermine the Civil Rights Act of 1964. This paper discusses current issues and challenges that pertain to…

  11. Affirmative Action Training Program for Firemen.

    ERIC Educational Resources Information Center

    MacBain, Z. E.

    This paper summarizes the "Affirmative Action" training of unskilled minorities for jobs as firemen. The various training approaches undertaken are discussed; some were more successful than others. Hopefully, the information provided in this report can be used by other fire departments as a basis for developing their own minority "Affirmative…

  12. Action Implications in Adult Basic Education Programs.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus.

    Eight articles on adult basic education are presented. The articles adapted from 1971 workshop presentations are: Action Implications for ABE Directors by Alan Knox; ABE Budget Development, by Donald G. Butcher; Competent ABE Instructors, by William D. Dowling; Interview Techniques and Training, by Norman Kagan; Reading: The Basic in Adult Basic…

  13. Action Research: Effective Marketing Strategies for a Blended University Program

    ERIC Educational Resources Information Center

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  14. Numerical simulation of rip-raps with the distinct element method

    NASA Astrophysics Data System (ADS)

    Mittelbach, Livia

    2013-06-01

    and costal shores. They have to resist hydraulic loads such as ship and wind induced waves, tidal and ship induced currents, tidal varying water levels and storm surges. The numerical modelling of rip-rap revetments is undertaken by using the Distinct Element Method in three dimensions. With the DEM rip-rap stones can be modelled as autonomous objects with any degrees of freedom. Typical shapes of stones are formed by using clumped spherical particles. A method for the generation of the rip-rap stones based on geometrical and probabilistic parameters has been developed in order to generate stones with a realistic size and mass distribution. The DEM program is coupled with a computational fluid dynamics program to account for the influence of the hydraulic loads on the rip-rap stones. The acting forces can be simulated realistically for waves, currents and tidal varying water levels. Field measurements and model tests serve as validation for the numerical model. Physical model tests are carried out in a hydraulic flume with an instrumented rip-rap section for the calibration of the numerical stones material parameters. The behaviour of the particles depends on properties such as density, friction coefficient, normal and shear stiffness as well as the accuracy of the numerical representation of the rip-rap stones. Influences on the accuracy of the modelling of rip-raps with regard to the variation of these parameters are examined by comparing the results of the physical flume tests and numerical model.

  15. Rap Music: An Education with a Beat from the Street.

    ERIC Educational Resources Information Center

    Powell, Catherine Tabb

    1991-01-01

    Examines rap music's origins as street music and poetry in the early 1970s and as an expression of Black youth experience. Discusses rap groups, women and Whites in rap, Christian rap, copyright disputes, and distribution difficulties. Rap is an informal educational medium that affects adolescents' values and attitudes. (JB)

  16. The Windana Therapeutic Community's Action Adventure Program.

    ERIC Educational Resources Information Center

    Price, Richard; DeBever, Marijke

    The Windana Society is a drug and alcohol agency in Victoria (Australia) that operates, among other things, a residential drug rehabilitation program in a rural setting. The program utilizes a holistic approach that addresses health and physical fitness; education; vocational and re-integration support; and psychological, emotional, spiritual, and…

  17. US Department of Energy Uranium Mill Tailings Remedial Action ground water Project. Revision 1, Version 1: Final project plan

    SciTech Connect

    Not Available

    1993-12-21

    The scope of the Project is to develop and implement a ground water compliance strategy for all 24 UMTRA processing sites. The compliance strategy for the processing sites must satisfy requirements of the proposed EPA ground water cleanup standards in 40 CFR Part 192, Subparts B and C (1988). This scope of work will entail the following activities, on a site-specific basis: Development of a compliance strategy based upon modification of the UMTRA Surface Project remedial action plans (RAP) or development of Ground Water Project RAPs with NRC and state or tribal concurrence on the RAP; implementation of the RAP to include establishment of institutional controls, where appropriate; institution of long-term verification monitoring for transfer to a separate DOE program on or before the Project end date; and preparation of completion reports and final licensing on those sites that will be completed prior to the Project end date.

  18. A novel neutralization sensitive and subdominant RAP-1-related antigen (RRA) is expressed by babesia bovis merozoites

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Objective: The Babesia bovis genome encodes a rap-1 related gene denominated RAP-1 related antigen (RRA). In this study, we analyzed the pattern of expression, immunogenicity and functional relevance of RRA. Methods: Phylogenetic analysis was performed using the program Phylip. Expression of rra wa...

  19. Science in action: An interdisciplinary science education program

    NASA Technical Reports Server (NTRS)

    Horton, Linda L.

    1992-01-01

    Science in Action is an education outreach program for pre-collegiate students. It is based on the concept that, in order to interest students in science, they must see science and scientists at work. The program encompasses the full range of scientific disciplines - the core sciences, engineering, and mathematics. A unique aspect of the program is the involvement and support of scientists and engineers representing local professional societies, industries, business, and academic institutions. An outline of the program is given.

  20. Regulation of Rap GTPases in mammalian neurons.

    PubMed

    Shah, Bhavin; Püschel, Andreas W

    2016-10-01

    Small GTPases are central regulators of many cellular processes. The highly conserved Rap GTPases perform essential functions in the mammalian nervous system during development and in mature neurons. During neocortical development, Rap1 is required to regulate cadherin- and integrin-mediated adhesion. In the adult nervous system Rap1 and Rap2 regulate the maturation and plasticity of dendritic spine and synapses. Although genetic studies have revealed important roles of Rap GTPases in neurons, their regulation by guanine nucleotide exchange factors (GEFs) that activate them and GTPase activating proteins (GAPs) that inactivate them by stimulating their intrinsic GTPase activity is just beginning to be explored in vivo. Here we review how GEFs and GAPs regulate Rap GTPases in the nervous system with a focus on their in vivo function.

  1. Regulation of Rap GTPases in mammalian neurons.

    PubMed

    Shah, Bhavin; Püschel, Andreas W

    2016-10-01

    Small GTPases are central regulators of many cellular processes. The highly conserved Rap GTPases perform essential functions in the mammalian nervous system during development and in mature neurons. During neocortical development, Rap1 is required to regulate cadherin- and integrin-mediated adhesion. In the adult nervous system Rap1 and Rap2 regulate the maturation and plasticity of dendritic spine and synapses. Although genetic studies have revealed important roles of Rap GTPases in neurons, their regulation by guanine nucleotide exchange factors (GEFs) that activate them and GTPase activating proteins (GAPs) that inactivate them by stimulating their intrinsic GTPase activity is just beginning to be explored in vivo. Here we review how GEFs and GAPs regulate Rap GTPases in the nervous system with a focus on their in vivo function. PMID:27186679

  2. Cancer survivorship programs: time for concerted action.

    PubMed

    Barbui, Tiziano; Björkholm, Magnus; Gratwohl, Alois

    2014-08-01

    Hematologists, specialists in cancer survivorship and patient advocates met in Bergamo, Italy (Nov 14–16, 2013) to highlight the physical, mental, psychosocial and financial challenges faced by cancer survivors and their families. Gaps in research and resources were all too apparent. This planned meeting perspective, not a formal consensus statement, reflects the key points mentioned by the participants during the discussions and the personal view of the authors. It proposes urgent action in key areas to ensure that people surviving cancer will suffer fewer long-term health problems than their predecessors and to contain costs. PMID:25082784

  3. The multifunctional transcription factor Rap1: a regulator of yeast physiology.

    PubMed

    Azad, Gajendra Kumar; Tomar, Raghuvir Singh

    2016-01-01

    Transcription is a fundamental process that is tightly regulated by transcription factors to maintain cellular homeostasis. Transcription factors have DNA-binding domains, some of which are sequence specific, and are found throughout the eukaryotic kingdom. Recent studies have revealed the molecular mechanisms by which transcription factors perform their functions. In the budding yeast Saccharomyces cerevisiae, Rap1 (ScRap1) can either activate or repress transcription. This bimodal transcriptional activity has led to the widespread study of the mode of action of ScRap1. This review summarizes current knowledge about yeast ScRap1, including its structure, mechanisms of transcription regulation, and biological functions, and the future directions in the field.

  4. Columbia University Affirmative Action Program (Condensed Version).

    ERIC Educational Resources Information Center

    Columbia Univ., New York, NY.

    Columbia University's equal employment opportunity policy is reviewed in relation to officers of instruction and research, officers of administration and support staff, and procedures and programs. Part I reaffirms the policy, indicates dissemination of the policy and reviews the responsibility for implementation of the policy. The officers of…

  5. EDUCATIONAL OPPORTUNITIES PROVIDED BY COMMUNITY ACTION PROGRAMS.

    ERIC Educational Resources Information Center

    PINNOCK, THEODORE J.

    INFORMAL EDUCATION PRIMARILY INCLUDES EDUCATION FOR EVERYDAY EFFECTIVE LIVING AND DOES NOT NECESSARILY HAVE TO INCLUDE COURSES FOR CREDIT AT THE HIGH SCHOOL AND COLLEGE LEVELS. MILLIONS OF POVERTY STRICKEN PEOPLE CAN BENEFIT FROM THE TYPE OF INFORMAL EDUCATION PROVIDED THROUGH THE OFFICE OF ECONOMIC OPPORTUNITY (OEO) IN SUCH PROGRAMS AS--(1) THE…

  6. Rap Music in School Counseling Based on Don Elligan's Rap Therapy

    ERIC Educational Resources Information Center

    Gonzalez, Tiphanie; Hayes, B. Grant

    2009-01-01

    In 2000, Don Elligan introduced Rap Therapy as a psychotherapeutic intervention for working with at-risk youths, primarily African American males whose identities were highly influenced by rap music. Rap music can engage a population of youth who often enter counseling apprehensively (Elligan 2000, 2004; Tillie-Allen, 2005). This article reviews…

  7. The GLOBE Program: Partnerships in Action

    NASA Astrophysics Data System (ADS)

    Henderson, S.; Kennedy, T.; Lemone, M.; Blurton, C.

    2004-12-01

    The GLOBE Program is a worldwide science and education partnership endeavor designed to increase scientific understanding of Earth as a system, support improved student achievement in science and math, and enhance environmental awareness through inquiry-based learning activities. GLOBE began on the premise that teachers and their students would partner with scientists to collect and analyze environmental data using specific protocols in five study areas - atmosphere, soils, hydrology, land cover, and phenology. As the GLOBE network grew, additional partnerships flourished making GLOBE an unprecedented collaboration of individuals worldwide - primary, secondary, and tertiary students, teachers and teacher educators, scientists, government officials, and others - to improve K-12 education. Since its inception in 1994, more than one million students in over 14,000 schools around the world have taken part in The GLOBE Program. The GLOBE Web site (http://www.globe.gov) is the repository for over 11 million student-collected data measurements easily accessible to students and scientists worldwide. Utilizing the advantages of the Internet for information sharing and communication, GLOBE has created an international community. GLOBE enriches students by giving them the knowledge and skills that they will need to become informed citizens and responsible decision-makers in an increasingly complex world. Understanding that all members of a community must support change if it is to be sustainable, GLOBE actively encourages the development of GLOBE Learning Communities (GLCs) which are designed to get diverse stakeholder groups involved in a local or regional environmental issue. Central to the GLC is the engagement of local schools. GLCs go beyond individual teachers implementing GLOBE in the isolation of their classrooms. Instead, the GLC brings multiple teachers and grade levels together to examine environmental issues encouraging the participation of a broad range of

  8. Ser756 of β2 integrin controls Rap1 activity during inside-out activation of αMβ2.

    PubMed

    Lim, Jenson; Hotchin, Neil A; Caron, Emmanuelle

    2011-08-01

    During αMβ2-mediated phagocytosis, the small GTPase Rap1 activates the β2 integrin by binding to a region between residues 732 and 761. Using COS-7 cells transfected with αMβ2, we show that αMβ2 activation by the phorbol ester PMA involves Ser(756) of β2. This residue is critical for the local positioning of talin and biochemically interacts with Rap1. Using the CaM (calmodulin) antagonist W7, we found Rap1 recruitment and the inside-out activation of αMβ2 to be affected. We also report a role for CaMKII (calcium/CaM-dependent kinase II) in the activation of Rap1 during integrin activation. These results demonstrate a distinct physiological role for Ser(756) of β2 integrin, in conjunction with the actions of talin and Rap1, during αMβ2 activation in macrophages.

  9. 48 CFR 1522.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Affirmative action programs. 1522.804 Section 1522.804 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Equal Employment Opportunity...

  10. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Corrective action programs. 192.33 Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards...

  11. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Corrective action programs. 192.33 Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards...

  12. 48 CFR 1422.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Affirmative action programs. 1422.804 Section 1422.804 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Equal Employment Opportunity...

  13. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  14. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  15. 48 CFR 1422.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Affirmative action programs. 1422.804 Section 1422.804 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Equal Employment Opportunity...

  16. Unwrapping Rap: A Literacy of Lived Experience.

    ERIC Educational Resources Information Center

    Brown, Stephen G.

    The adversarial forces of governmental censorship, freedom of expression, and capitalistic appropriation are engaged in an acrimonious debate over "Gangsta' Rap" that is being played out in the public spaces of popular culture. However, as a literacy of lived experience, Gangsta' Rap warrants critical investigation. Many postmodern theorists have…

  17. Black Essentialism: The Art of Jazz Rap.

    ERIC Educational Resources Information Center

    Stewart, Earl; Duran, Jane

    1999-01-01

    Establishes a black essentialist aesthetic for jazz rap, showing its relation to an African-derived history and other black traditions. Examines newer lines of argument in aesthetics about contemporary recordings focusing on Theodore Gracyk. Argues that jazz rap is defined by actual, not recorded, performance. (CMK)

  18. Library Programs. LSCA Programs: An Action Report II.

    ERIC Educational Resources Information Center

    Office of Educational Research and Improvement (ED), Washington, DC.

    The eight reports featured in this publication detail the accomplishments of the State Grant Program (Titles I through IV) funded by the Library Services and Construction Act (LSCA). Written by members of the Public Library Support Staff, these descriptions are based on state and local library reports on how they meet a variety of users' needs.…

  19. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner or... through 270.66 do not apply to RAPs unless those requirements for traditional RCRA permits are... requirements in this section constitutes a RCRA permit under RCRA section 3005(c). (d) A RAP may be: (1)...

  20. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner or... through 270.66 do not apply to RAPs unless those requirements for traditional RCRA permits are... requirements in this section constitutes a RCRA permit under RCRA section 3005(c). (d) A RAP may be: (1)...

  1. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner or... through 270.66 do not apply to RAPs unless those requirements for traditional RCRA permits are... requirements in this section constitutes a RCRA permit under RCRA section 3005(c). (d) A RAP may be: (1)...

  2. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include...

  3. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include...

  4. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include...

  5. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... contents of affirmative action programs. 60-2.10 Section 60-2.10 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.10 General purpose and contents of affirmative action programs. (a) Purpose....

  6. 41 CFR 60-741.46 - Voluntary affirmative action programs for employees with disabilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS, EQUAL EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION... Action Program § 60-741.46 Voluntary affirmative action programs for employees with disabilities. (a) The... contractor elects to implement a voluntary affirmative action program for employees with disabilities,...

  7. A Format for Packaging Your Affirmative Action Program.

    ERIC Educational Resources Information Center

    Brookmire, David A.; Burton, Amy A.

    1978-01-01

    In order to standardize procedures for corporate affirmative action programs (AAP) in compliance with all of the diverse federal legislation and regulations, the authors present an AAP manual format which has been approved by each interested federal agency and by the Office of Federal Contracts Compliance. (MF)

  8. 41 CFR 60-1.40 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Affirmative action programs. 60-1.40 Section 60-1.40 Public Contracts and Property Management Other Provisions Relating to... OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Ancillary Matters § 60-1.40...

  9. 41 CFR 60-1.40 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Affirmative action programs. 60-1.40 Section 60-1.40 Public Contracts and Property Management Other Provisions Relating to... OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Ancillary Matters § 60-1.40...

  10. 41 CFR 60-1.40 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Affirmative action programs. 60-1.40 Section 60-1.40 Public Contracts and Property Management Other Provisions Relating to... OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Ancillary Matters § 60-1.40...

  11. 41 CFR 60-1.40 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Affirmative action programs. 60-1.40 Section 60-1.40 Public Contracts and Property Management Other Provisions Relating to... OF LABOR 1-OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS Ancillary Matters § 60-1.40...

  12. Affirmative Action Education Programs for Siberian Native People.

    ERIC Educational Resources Information Center

    Bartels, Dennis; Bartels, Alice

    1984-01-01

    Describes origin and development of programs, focusing on affirmative action at the Faculty of Northern Peoples of Leningrad's Herzen Pedagogical Institute. Offers conclusions and implications for North America. Includes extensive bibliography, tables on Siberian populations and languages, and biographies of two Siberian educators and two female…

  13. A Participatory Action Research Approach To Evaluating Inclusive School Programs.

    ERIC Educational Resources Information Center

    Dymond, Stacy K.

    2001-01-01

    This article proposes a model for evaluating inclusive schools. Key elements of the model are inclusion of stakeholders in the evaluation process through a participatory action research approach, analysis of program processes and outcomes, use of multiple methods and measures, and obtaining perceptions from diverse stakeholder groups. (Contains…

  14. The FCEOC Library: A Community Action Program. Operations Manual.

    ERIC Educational Resources Information Center

    Scott, R. E.

    The Fresno County (California) Economic Opportunities Commission (FCEOC) library produced this policy, procedures, and use manual as a guide for community action programs. The manual includes information on structure and use of the card catalog, organization of materials, use and organization of the vertical file, organization of grant research…

  15. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....11, 72.12 and 72.13 may be satisfied by local governments' submission of a Preliminary Action Program... Act of 1978, Pub. L. 95-625, (16 U.S.C. 2506); sec. 2 of Reorganization Plan No. 3 of 1950 (34...

  16. Current activities handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-27

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the activities each of the thirteen state legislatures potentially affected by the Formerly Utilized Sites Remedial Action Program. It contains a description of the state legislative procedural rules and a schedule of each legislative session; a summary of pending relevant legislation; the name and telephone number of legislative and state agency contacts; and the full text of all bills identified.

  17. Hazardous Waste Remedial Actions Program annual progress report, FY 1990

    SciTech Connect

    Not Available

    1990-12-01

    The Hazardous Waste Remedial Actions Programs (HAZWRAP), a unit of Martin Marietta Energy Systems, Inc., supports the Department of Energy (DOE) Oak Ridge Operations Office in broadly environmental areas, especially those relating to waste management and environmental restoration. HAZWRAP comprises six program areas, which are supported by central administrative and technical organizations. Existing programs deal with airborne hazardous substances, pollution prevention, remedial actions planning, environmental restoration, technology development, and information and data systems. HAZWRAP's mission to develop, promote, and apply-cost-effective hazardous waste management and environmental technologies to help solve national problems and concerns. HAZWRAP seeks to serve as integrator for hazardous waste and materials management across the federal government. It applies the unique combination of research and development (R D) capabilities, technologies, management expertise, and facilities in the Energy Systems complex to address problems of national importance. 24 figs., 10 tabs.

  18. Optimizing Canadian public immunization programs: a prescription for action.

    PubMed

    Scheifele, David W; Naus, Monika; Crowcroft, Natasha S; Dobson, Simon; Halperin, Scott A; Bjornson, Gordean

    2011-01-01

    Recent expansion of public vaccination programs for children and youth offers new health benefits but at substantially increased cost. As with other large public investments, immunization programs ought to be systematically evaluated for safety, effectiveness and economic value. At present, program evaluations are suboptimal in most provinces and territories. Experts in public health and vaccinology who attended a workshop in 2009 reviewed the shortcomings and produced "prescriptions for action" to improve matters. Six key recommendations were made: 1) a formal requirement should exist to evaluate all public vaccination programs appropriately; 2) greater voluntary harmonization of programs will facilitate evaluations; 3) a mechanism is needed to prioritize and coordinate program-specific evaluations; 4) new funding mechanisms are needed for basic jurisdictional studies and joint studies of broad relevance; 5) strong emphasis is needed on capacity development and training; and 6) administrative barriers to accessing health information systems and publishing evaluation studies need to be overcome. The expert group considered the need to improve program evaluations as urgent and compelling, with success achievable with dedicated funding and effective leadership. Demonstrating that Canadian immunization programs are among the world's best and safest is a sound strategy for maintaining public participation in those programs.

  19. Pennsylvania state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and State levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  20. Ohio state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    Not Available

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Ohio. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.

  1. Oregon state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  2. Florida state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-27

    This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the federal and state levels, the pertinent programs they administer, each affected state legislature, and current federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Florida. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  3. Iowa state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-09

    This volume is one of a series produced under contract with the DOE, By Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Iowa. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.

  4. Maryland State information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Handbook Series Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Maryland. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  5. California state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of California. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.

  6. Massachusetts state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Massachusetts. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.

  7. Oregon state information handbook formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administater, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  8. The Utility of the Racial Attitudes and Perceptions Survey (RAPS) for Assessing Impact of Race Relations Training Programs in the Military. Final Report. (Mar 73-Mar 74). Technical Paper 339.

    ERIC Educational Resources Information Center

    Hiett, Robert L.; And Others

    The Racial Attitudes and Perceptions Survey (RAPS) consists of four scales: perceived discrimination against blacks; attitude toward racial interaction; feelings of reverse racism; and racial climate. This instrument was administered to approximately 10,000 military personnel in a variety of research designs to determine the impact of race…

  9. Effects of using nursing home residents to serve as group activity leaders: lessons learned from the RAP project.

    PubMed

    Skrajner, Michael J; Haberman, Jessica L; Camp, Cameron J; Tusick, Melanie; Frentiu, Cristina; Gorzelle, Gregg

    2014-03-01

    Previous research has demonstrated that persons with early to moderate stage dementia are capable of leading small group activities for persons with more advanced dementia. In this study, we built upon this previous work by training residents in long-term care facilities to fill the role of group activity leaders using a Resident-Assisted Programming (RAP) training regimen. There were two stages to the program. In the first stage, RAP training was provided by researchers. In the second stage, RAP training was provided to residents by activities staff members of long-term care facilities who had been trained by researchers. We examine the effects of RAP implemented by researchers and by activities staff member on long-term care resident with dementia who took part in these RAP activities. We also examined effects produced by two types of small group activities: two Montessori-based activities and an activity which focuses on persons with more advanced dementia, based on the work of Jitka Zgola. Results demonstrate that levels of positive engagement seen in players during RAP (resident-led activities) were typically higher than those observed during standard activities programming led by site staff. In general, Montessori-Based Dementia Programming® produced more constructive engagement than Zgola-based programming (ZBP), though ZBP did increase a positive form of engagement involving observing activities with interest. In addition, RAP implemented by activities staff members produced effects that were, on the whole, similar to those produced when RAP was implemented by researchers. Implications of these findings for providing meaningful social roles for persons with dementia residing in long-term care, and suggestions for further research in this area, are discussed.

  10. The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.

    PubMed

    Scrima, Andrea; Thomas, Christoph; Deaconescu, Delia; Wittinghofer, Alfred

    2008-04-01

    The GTP-binding protein Rap1 regulates integrin-mediated and other cell adhesion processes. Unlike most other Ras-related proteins, it contains a threonine in switch II instead of a glutamine (Gln61 in Ras), a residue crucial for the GTPase reaction of most G proteins. Furthermore, unlike most other GTPase-activating proteins (GAPs) for small G proteins, which supply a catalytically important Arg-finger, no arginine residue of RapGAP makes a significant contribution to the GTPase reaction of Rap1. For a detailed understanding of the reaction mechanism, we have solved the structure of Rap1 in complex with Rap1GAP. It shows that the Thr61 of Rap is away from the active site and that an invariant asparagine of RapGAPs, the Asn-thumb, takes over the role of the cis-glutamine of Ras, Rho or Ran. The structure and biochemical data allow to further explain the mechanism and to define the important role of a conserved tyrosine. The structure and biochemical data furthermore show that the RapGAP homologous region of the tumour suppressor Tuberin is sufficient for catalysis on Rheb.

  11. Regulating Rap small G-proteins in time and space.

    PubMed

    Gloerich, Martijn; Bos, Johannes L

    2011-10-01

    Signaling by the small G-protein Rap is under tight regulation by its GEFs and GAPs. These are multi-domain proteins that are themselves controlled by distinct upstream pathways, and thus couple different extra- and intracellular cues to Rap. The individual RapGEFs and RapGAPs are, in addition, targeted to specific cellular locations by numerous anchoring mechanisms and, consequently, may control different pools of Rap. Here, we review the various activating signals and targeting mechanisms of these proteins and discuss their contribution to the spatiotemporal regulation and biological functions of the Rap proteins.

  12. Expedited Remedial Action Program (SB 923): A California Brownfields initiative

    SciTech Connect

    Cambridge, M.; Wolfenden, A.K.

    1996-12-31

    California`s Expedited Remedial Action Program (ERAP) created a comprehensive program that promotes an equitable and expedited approach for redevelopment of properties contaminated with hazardous substances. This bill embodies an emerging trend in environmental policy that permits flexibility, cooperation and creativity without compromising protection to public health or the environment. Within the California Environmental Protection Agency, the Department of Toxic Substances Control (DTSC) is promoting a number of programs to facilitate the restoration of contaminated properties as part of its Brownfields initiative. ERAP represents a potentially more efficient process to remediate sites by minimizing economic risks through a clearly identified liability scheme, indemnifying future owners through a covenant not to sue, and providing risk based cleanups that are based on the permanent use of the site.

  13. Science in Action'': An interdisciplinary science education program

    SciTech Connect

    Horton, L.L.

    1991-01-01

    Science in Action is an education outreach program for pre-collegiate students. It is based on the concept that, in order to interest students in science, they must see science and scientists at work. The program encompasses the full range of scientific disciplines -- the core sciences, engineering and mathematics. A unique aspect of the program is the involvement and support of scientists and engineers representing local professional societies, industries, businesses, and academic institutions. The goal of the presentations is to be highly interactive. The students have some hands on'' experiences and leave with a good feeling about science and engineering. To present a broad spectrum of role models, scientists and engineers were involved as presenters, guides, and exhibitors.

  14. Missouri State information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Missouri. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature chairmen, and a summary of recent relevant legislative action; a description of the organization and structure of local governments affected by remedial action at the St. Louis area sites; a summary of relevant local ordinances and regulations; an identification of relevant public interest groups; a list of radio stations, television stations, and newspapers that provide public information to the St. Louis area or to Jefferson City; and the full text of relevant statutes and regulations.

  15. Rap Music and Its Violent Progeny: America's Culture of Violence in Context.

    ERIC Educational Resources Information Center

    Richardson, Jeanita W.; Scott, Kim A.

    2002-01-01

    Considers rap music as a creative expression and metaphorical offspring of America's well-established culture of violence, highlighting rap music in the context of a violent culture; violence in music; rap, cultural capital, and social reproduction; rap in the scholarly literature; political and judicial scrutiny of rap; and capitalism and rap.…

  16. Risk assessment in the DOE Assurance Program for Remedial Action

    SciTech Connect

    Marks, S.; Cross, F.T.; Denham, D.H.; Kennedy, W.E.; Stenner, R.D.

    1985-08-01

    This document provides information obtained during the performance of risk assessment tasks in support of the Assurance Program for Remedial Action (APRA) sponsored by the Office of Operational Safety of the Department of Energy. We have presented a method for the estimation of projected health effects at properties in the vicinity of uranium mill tailing piles due to transported tailings or emissions from the piles. Because radon and radon daughter exposure is identified as the principal factor contributing to health effects at such properties, the basis for estimating lung cancer risk as a result of such exposure is discussed in detail. Modeling of health risk due to a secondary pathway, ingestion of contaminated, home-grown food products, is also discussed since it is a potentially important additional source of exposure in certain geographic locations. Risk assessment methods used in various mill tailings reports are reviewed. The protocols for radiological surveys conducted in DOE-sponsored remedial action programs are critically reviewed with respect to their relevance to the needs of health risk estimation. The relevance of risk assessment to the APRA program is discussed briefly.

  17. Entrepreneurial Learning through Action: A Case Study of the Six-Squared Program

    ERIC Educational Resources Information Center

    Pittaway, Luke; Missing, Caroline; Hudson, Nigel; Maragh, Dean

    2009-01-01

    This paper explores the role of "action" in entrepreneurial learning and illustrates how programs designed to support action learning can enhance management development in entrepreneurial businesses. The paper begins by exploring action learning and the way "action" is conceived in different types of program. In the second part, the paper details…

  18. [Biological Function of The Small G Protein Rap].

    PubMed

    Li, Shan-Shan; Guo, Xiao-Xi; An, Shu; Yang, Yang; Liu, Ying; Xu, Tian-Rui

    2016-02-01

    Rap has different biological functions on intracellular signaling pathways, such as regulating cell polarity, cell proliferation, cell differentiation, cell adhesion and cell movement. Furthermore, at tissue and organ level, Rap controls the establishment of neural polarity, synaptic growth, synaptic plasticity, neuronal migration and so on. Rap belongs to Ras family which contains two subtypes, Rap1 and Rap2. By binding GTP or GDP Rap transform between active or inactive state, and plays an important role as a molecular switch. Moreover, in the signal pathway of tumor, Rap inhibits cell transformation induced by the oncogene Ras, therefore inhibits the proliferation, invasion and migration of certain cancer cells by interacting with its downstream target molecules. In this review, we summarized the biological functions of Rap and discussed It's significance in cancer therapy and drug treatment of neurological diseases.

  19. [Biological Function of The Small G Protein Rap].

    PubMed

    Li, Shan-Shan; Guo, Xiao-Xi; An, Shu; Yang, Yang; Liu, Ying; Xu, Tian-Rui

    2016-02-01

    Rap has different biological functions on intracellular signaling pathways, such as regulating cell polarity, cell proliferation, cell differentiation, cell adhesion and cell movement. Furthermore, at tissue and organ level, Rap controls the establishment of neural polarity, synaptic growth, synaptic plasticity, neuronal migration and so on. Rap belongs to Ras family which contains two subtypes, Rap1 and Rap2. By binding GTP or GDP Rap transform between active or inactive state, and plays an important role as a molecular switch. Moreover, in the signal pathway of tumor, Rap inhibits cell transformation induced by the oncogene Ras, therefore inhibits the proliferation, invasion and migration of certain cancer cells by interacting with its downstream target molecules. In this review, we summarized the biological functions of Rap and discussed It's significance in cancer therapy and drug treatment of neurological diseases. PMID:27424400

  20. Formerly Utilized Sites Remedial Action Program environmental compliance assessment checklists

    SciTech Connect

    Levine, M.B.; Sigmon, C.F.

    1989-09-29

    The purpose of the Environmental Compliance Assessment Program is to assess the compliance of Formerly Utilized Site Remedial Action Program (FUSRAP) sites with applicable environmental regulations and Department of Energy (DOE) Orders. The mission is to identify, assess, and decontaminate sites utilized during the 1940s, 1950s, and 1960s to process and store uranium and thorium ores in support of the Manhattan Engineer District and the Atomic Energy Commission. To conduct the FUSRAP environmental compliance assessment, checklists were developed that outline audit procedures to determine the compliance status of the site. The checklists are divided in four groups to correspond to these regulatory areas: Hazardous Waste Management, PCB Management, Air Emissions, and Water Discharges.

  1. Structure, functional regulation and signaling properties of Rap2B

    PubMed Central

    QU, DEBAO; HUANG, HUI; DI, JIEHUI; GAO, KEYU; LU, ZHENG; ZHENG, JUNNIAN

    2016-01-01

    The Ras family small guanosine 5′-triphosphate (GTP)-binding protein Rap2B is is a member of the Ras oncogene family and a novel target of p53 that regulates the p53-mediated pro-survival function of cells. The Rap2B protein shares ~90% homology with Rap2A, and its sequence is 70% identical to other members of the Rap family such as RaplA and RaplB. As a result, Rap2B has been theorized to have similar signaling effectors to the GTPase-binding protein Rap, which mediates various biological functions, including the regulation of sterile 20/mitogen-activated proteins. Since its identification in the early 1990s, Rap2B has elicited a considerable interest. Numerous studies indicate that Rap2B exerts specific biological functions, including binding and stimulating phospholipase C-ε and interferon-γ. In addition, downregulation of Rap2B affects the growth of melanoma cells. The present review summarizes the possible effectors and biological functions of Rap2B. Increasing evidence clearly supports the association between Rap2B function and tumor development. Therefore, it is conceivable that anticancer drugs targeting Rap2B may be generated as novel therapies against cancer. PMID:27073477

  2. Dialogic Teaching in an Online Environment: Book Raps

    ERIC Educational Resources Information Center

    Simpson, Alyson

    2010-01-01

    This paper examines a blended learning context known as book raps where children read and respond to literary texts. In this particular e-literacy environment, readers discuss their opinions of a book under the guidance of a moderator known as a rap coordinator who provides stimulus questions known as rap points. The paper demonstrates how…

  3. Cultural Studies and Rap: The Poetry of an Urban Lyricist

    ERIC Educational Resources Information Center

    Parmar, Priya

    2005-01-01

    In this article, the author explores the many other faces of rap that do not get the media exposure that they rightfully deserve. As this article attempts to reveal, rap music, as a form of cultural pedagogy and critical literacy, is only one way to achieve the goals of a "critical education." Rap lyrics can also be used as a tool to help the…

  4. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What is a RAP? 270.80 Section 270.80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) EPA... Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  5. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What is a RAP? 270.80 Section 270.80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) EPA... Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  6. From science to action and from action to science: the Nunavik Trichinellosis Prevention Program

    PubMed Central

    Larrat, Sylvain; Simard, Manon; Lair, Stéphane; Bélanger, Denise; Proulx, Jean-François

    2012-01-01

    Objectives During the 1980s, walrus-meat consumption caused infections with the parasite Trichinella nativa in Nunavik inhabitants. In response to these events, stakeholders set up the community-based Nunavik Trichinellosis Prevention Program (NTPP). The objectives of the present communication are to review the NTPP, describe how science and action were interwoven in its development and identify its assets and limitations. Study design Descriptive study. Methods The NTPP relies on a pooled digestion assay of tongue samples taken from each harvested walrus. The public health recommendations depend on the results of the analyses: infected walrus meat should be destroyed; parasite-free meat may be eaten raw or cooked. Results All communities involved in the walrus hunt participate in the NTPP and a high percentage of harvested walruses are included in the NTPP. Infected animals account for 2.9% of the walruses tested (20/694) since 1992. The NTPP permitted the early management of a trichinellosis event in 1997. Since then, it prevented the new occurrence of outbreaks related to walruses hunted by Nunavimmiut. Conclusions The absence of recent major outbreaks of trichinellosis in Nunavik may reasonably be attributed to the NTPP. The success of the program stands on many facilitating factors such as the nature of the disease and its source, the existence of an efficient analytic method, the strong involvement of the different partners including direct resource users, as well as the comprehensive bidirectional science-to-action approach that has been followed. PMID:22789519

  7. Telomere protein RAP1 levels are affected by cellular aging and oxidative stress

    PubMed Central

    Swanson, Mark J.; Baribault, Michelle E.; Israel, Joanna N.; Bae, Nancy S.

    2016-01-01

    Telomeres are important for maintaining the integrity of the genome through the action of the shelterin complex. Previous studies indicted that the length of the telomere did not have an effect on the amount of the shelterin subunits; however, those experiments were performed using immortalized cells with stable telomere lengths. The interest of the present study was to observe how decreasing telomere lengths over successive generations would affect the shelterin subunits. As neonatal human dermal fibroblasts aged and their telomeres became shorter, the levels of the telomere-binding protein telomeric repeat factor 2 (TRF2) decreased significantly. By contrast, the levels of one of its binding partners, repressor/activator protein 1 (RAP1), decreased to a lesser extent than would be expected from the decrease in TRF2. Other subunits, TERF1-interacting nuclear factor 2 and protection of telomeres protein 1, remained stable. The decrease in RAP1 in the older cells occurred in the nuclear and cytoplasmic fractions. Hydrogen peroxide (H2O2) stress was used as an artificial means of aging in the cells, and this resulted in RAP1 levels decreasing, but the effect was only observed in the nuclear portion. Similar results were obtained using U251 glioblastoma cells treated with H2O2 or grown in serum-depleted medium. The present findings indicate that TRF2 and RAP1 levels decrease as fibroblasts naturally age. RAP1 remains more stable compared to TRF2. RAP1 also responds to oxidative stress, but the response is different to that observed in aging. PMID:27446538

  8. Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger.

    PubMed

    Hochbaum, Daniel; Tanos, Tamara; Ribeiro-Neto, Fernando; Altschuler, Daniel; Coso, Omar A

    2003-09-01

    Guanine nucleotide exchange factors (GEFs) and their associated GTP-binding proteins (G-proteins) are key regulatory elements in the signal transduction machinery that relays information from the extracellular environment into specific intracellular responses. Among them, the MAPK cascades represent ubiquitous downstream effector pathways. We have previously described that, analogous to the Ras-dependent activation of the Erk-1/2 pathway, members of the Rho family of small G-proteins activate the JNK cascade when GTP is loaded by their corresponding GEFs. Searching for novel regulators of JNK activity we have identified Epac (exchange protein activated by cAMP) as a strong activator of JNK-1. Epac is a member of a growing family of GEFs that specifically display exchange activity on the Rap subfamily of Ras small G-proteins. We report here that while Epac activates the JNK severalfold, a constitutively active (G12V) mutant of Rap1b does not, suggesting that Rap-GTP is not sufficient to transduce Epac-dependent JNK activation. Moreover, Epac signaling to the JNKs was not blocked by inactivation of endogenous Rap, suggesting that Rap activation is not necessary for this response. Consistent with these observations, domain deletion mutant analysis shows that the catalytic GEF domain is dispensable for Epac-mediated activation of JNK. These studies identified a region overlapping the Ras exchange motif domain as critical for JNK activation. Consistent with this, an isolated Ras exchange motif domain from Epac is sufficient to activate JNK. We conclude that Epac signals to the JNK cascade through a new mechanism that does not involve its canonical catalytic action, i.e. Rap-specific GDP/GTP exchange. This represents not only a novel way to activate the JNKs but also a yet undescribed mechanism of downstream signaling by Epac.

  9. RapA2 Is a Calcium-binding Lectin Composed of Two Highly Conserved Cadherin-like Domains That Specifically Recognize Rhizobium leguminosarum Acidic Exopolysaccharides*

    PubMed Central

    Abdian, Patricia L.; Caramelo, Julio J.; Ausmees, Nora; Zorreguieta, Angeles

    2013-01-01

    In silico analyses have revealed a conserved protein domain (CHDL) widely present in bacteria that has significant structural similarity to eukaryotic cadherins. A CHDL domain was shown to be present in RapA, a protein that is involved in autoaggregation of Rhizobium cells, biofilm formation, and adhesion to plant roots as shown by us and others. Structural similarity to cadherins suggested calcium-dependent oligomerization of CHDL domains as a mechanistic basis for RapA action. Here we show by circular dichroism spectroscopy, light scattering, isothermal titration calorimetry, and other methods that RapA2 from Rhizobium leguminosarum indeed exhibits a cadherin-like β-sheet conformation and that its proper folding and stability are dependent on the binding of one calcium ion per protein molecule. By further in silico analysis we also reveal that RapA2 consists of two CHDL domains and expand the range of CHDL-containing proteins in bacteria and archaea. However, light scattering assays at various concentrations of added calcium revealed that RapA2 formed neither homo-oligomers nor hetero-oligomers with RapB (a distinct CHDL protein), indicating that RapA2 does not mediate cellular interactions through a cadherin-like mechanism. Instead, we demonstrate that RapA2 interacts specifically with the acidic exopolysaccharides (EPSs) produced by R. leguminosarum in a calcium-dependent manner, sustaining a role of these proteins in the development of the biofilm matrix made of EPS. Because EPS binding by RapA2 can only be attributed to its two CHDL domains, we propose that RapA2 is a calcium-dependent lectin and that CHDL domains in various bacterial and archaeal proteins confer carbohydrate binding activity to these proteins. PMID:23235153

  10. Federal government information handbook: formerly utilized sites remedial action program

    SciTech Connect

    Not Available

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations.

  11. A Three Step Plan for Implementing an Affirmative Action Program

    ERIC Educational Resources Information Center

    Hilaael, Timothy M.

    1976-01-01

    (1) Centralize organizational responsibility for affirmative action. (2) Conduct an organizational audit related to the Equal Employment Opportunity Act. (3) Implement affirmative action as an administrative responsibility. (Author)

  12. CDK5RAP2 is required for spindle checkpoint function.

    PubMed

    Zhang, Xiaoying; Liu, Dongyun; Lv, Shuang; Wang, Haibo; Zhong, Xueyan; Liu, Bo; Wang, Bo; Liao, Ji; Li, Jing; Pfeifer, Gerd P; Xu, Xingzhi

    2009-04-15

    The combination of paclitaxel and doxorubicin is among the most successful chemotherapy regimens in cancer treatment. CDK5RAP2, when mutated, causes primary microcephaly. We show here that inhibition of CDK5RAP2 expression causes chromosome mis-segregation, fails to maintain the spindle checkpoint, and is associated with reduced expression of the spindle checkpoint proteins BUBR1 and MAD2 and an increase in chromatin-associated CDC20. CDK5RAP2 resides on the BUBR1 and MAD2 promoters and regulates their transcription. Furthermore, CDK5RAP2-knockdown cells have increased resistance to paclitaxel and doxorubicin, and this resistance is partially rescued upon restoration of CDK5RAP2 expression. Cancer cells cultured in the presence of paclitaxel or doxorubicin exhibit dramatically decreased CDK5RAP2 levels. These results suggest that CDK5RAP2 is required for spindle checkpoint function and is a common target in paclitaxel and doxorubicin resistance. PMID:19282672

  13. Rapping the 27 Amendments to the Constitution

    ERIC Educational Resources Information Center

    Knaresborough, Adam

    2009-01-01

    Early in the year, the students of history and government at Mountain View High School in Stafford, Virginia, began to devise hand motions to help memorize the 27 amendments to the Constitution for government class. Three students in the school who are interested in hip hop music then suggested composing a rap song about the topic. Working with…

  14. The Rap on Hip-Hop

    ERIC Educational Resources Information Center

    Piekarski, Bill

    2004-01-01

    From its humble origins some 30 years ago in New York's bombed-out, poverty-ravaged South Bronx, hip-hop has risen to become a dominant cultural force both here and abroad. Strictly defined, the term refers to the entire cultural constellation that accompanies rap music, which in 2001 surpassed country music as the most popular musical genre in…

  15. 42 CFR 431.820 - Corrective action under the MEQC program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION Quality... program. The agency must— (a) Take action to correct any active or negative case action errors found in the sample cases; (b) Take administrative action to prevent or reduce the incidence of those...

  16. 42 CFR 431.820 - Corrective action under the MEQC program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION Quality... program. The agency must— (a) Take action to correct any active or negative case action errors found in the sample cases; (b) Take administrative action to prevent or reduce the incidence of those...

  17. 42 CFR 431.820 - Corrective action under the MEQC program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION Quality... program. The agency must— (a) Take action to correct any active or negative case action errors found in the sample cases; (b) Take administrative action to prevent or reduce the incidence of those...

  18. 41 CFR 60-741.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... affirmative action program. 60-741.41 Section 60-741.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program § 60-741.41 Availability...

  19. 41 CFR 60-250.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action program requirement. 60-250.40 Section 60-250.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.40 Applicability of...

  20. 41 CFR 60-250.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... affirmative action program. 60-250.41 Section 60-250.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.41 Availability of affirmative...

  1. 41 CFR 60-741.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... affirmative action program requirement. 60-741.40 Section 60-741.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program §...

  2. 41 CFR 60-300.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... affirmative action program. 60-300.41 Section 60-300.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF FEDERAL... OR CAMPAIGN BADGE VETERANS, AND ARMED FORCES SERVICE MEDAL VETERANS Affirmative Action Program §...

  3. 41 CFR 60-300.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... affirmative action program requirement. 60-300.40 Section 60-300.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... VETERANS, AND ARMED FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.40 Applicability...

  4. 41 CFR 60-250.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... affirmative action program requirement. 60-250.40 Section 60-250.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.40 Applicability of...

  5. 41 CFR 60-250.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action program requirement. 60-250.40 Section 60-250.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.40 Applicability of...

  6. 41 CFR 60-250.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action program. 60-250.41 Section 60-250.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.41 Availability of affirmative...

  7. 41 CFR 60-741.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... affirmative action program. 60-741.41 Section 60-741.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF FEDERAL CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program §...

  8. 41 CFR 60-741.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action program requirement. 60-741.40 Section 60-741.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program §...

  9. 41 CFR 60-300.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action program. 60-300.41 Section 60-300.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.41 Availability of affirmative...

  10. 41 CFR 60-300.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action program requirement. 60-300.40 Section 60-300.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... VETERANS, AND ARMED FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.40 Applicability...

  11. 41 CFR 60-300.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... affirmative action program. 60-300.41 Section 60-300.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.41 Availability of affirmative...

  12. 41 CFR 60-250.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action program. 60-250.41 Section 60-250.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.41 Availability of affirmative...

  13. 41 CFR 60-741.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... affirmative action program requirement. 60-741.40 Section 60-741.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program §...

  14. 41 CFR 60-741.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action program requirement. 60-741.40 Section 60-741.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program §...

  15. 41 CFR 60-741.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action program. 60-741.41 Section 60-741.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program § 60-741.41 Availability...

  16. 41 CFR 60-250.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... affirmative action program. 60-250.41 Section 60-250.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 250-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.41 Availability of affirmative...

  17. 41 CFR 60-300.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... affirmative action program. 60-300.41 Section 60-300.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.41 Availability of affirmative...

  18. 41 CFR 60-741.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... affirmative action program. 60-741.41 Section 60-741.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program § 60-741.41 Availability...

  19. 41 CFR 60-300.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... affirmative action program. 60-300.41 Section 60-300.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND... FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.41 Availability of affirmative...

  20. 41 CFR 60-741.41 - Availability of affirmative action program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action program. 60-741.41 Section 60-741.41 Public Contracts and Property Management Other... OPPORTUNITY, DEPARTMENT OF LABOR 741-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF CONTRACTORS AND SUBCONTRACTORS REGARDING INDIVIDUALS WITH DISABILITIES Affirmative Action Program § 60-741.41 Availability...

  1. 41 CFR 60-300.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... affirmative action program requirement. 60-300.40 Section 60-300.40 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 300-AFFIRMATIVE ACTION AND NONDISCRIMINATION OBLIGATIONS OF... VETERANS, AND ARMED FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.40 Applicability...

  2. Structural Basis of Response Regulator Dephosphorylation by Rap Phosphatases

    SciTech Connect

    V Parashar; N Mirouze; D Dubnau; M Neiditch

    2011-12-31

    Bacterial Rap family proteins have been most extensively studied in Bacillus subtilis, where they regulate activities including sporulation, genetic competence, antibiotic expression, and the movement of the ICEBs1 transposon. One subset of Rap proteins consists of phosphatases that control B. subtilis and B. anthracis sporulation by dephosphorylating the response regulator Spo0F. The mechanistic basis of Rap phosphatase activity was unknown. Here we present the RapH-Spo0F X-ray crystal structure, which shows that Rap proteins consist of a 3-helix bundle and a tetratricopeptide repeat domain. Extensive biochemical and genetic functional studies reveal the importance of the observed RapH-Spo0F interactions, including the catalytic role of a glutamine in the RapH 3-helix bundle that inserts into the Spo0F active site. We show that in addition to dephosphorylating Spo0F, RapH can antagonize sporulation by sterically blocking phosphoryl transfer to and from Spo0F. Our structure-function analysis of the RapH-Spo0F interaction identified Rap protein residues critical for Spo0F phosphatase activity. This information enabled us to assign Spo0F phosphatase activity to a Rap protein based on sequence alone, which was not previously possible. Finally, as the ultimate test of our newfound understanding of the structural requirements for Rap phosphatase function, a non-phosphatase Rap protein that inhibits the binding of the response regulator ComA to DNA was rationally engineered to dephosphorylate Spo0F. In addition to revealing the mechanistic basis of response regulator dephosphorylation by Rap proteins, our studies support the previously proposed T-loop-Y allostery model of receiver domain regulation that restricts the aromatic 'switch' residue to an internal position when the {beta}4-{alpha}4 loop adopts an active-site proximal conformation.

  3. A Critique of Motivational Bases for Affirmative Action Programs in Postsecondary Education.

    ERIC Educational Resources Information Center

    Barger, Robert N.

    Motivational bases for affirmative action programs, particularly as these programs pertain to postsecondary education, are considered. "Motivational bases" refers to the basic incentives that are invoked in order to gain public support for affirmative action programs. Three types of motivational bases are addressed: those associated with reasons…

  4. From Knowledge to Action: Tips for Encouraging and Measuring Program-Related Behavior Change

    ERIC Educational Resources Information Center

    Chazdon, Scott; Horntvedt, Jody; Templin, Elizabeth

    2016-01-01

    It is challenging to document the behavior changes that result from Extension programming. This article describes an evaluation method we call the "action items method." Unlike other approaches for measuring behavior change, this method requires program participants to define their own action plans as part of a program and then asks them…

  5. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Identification of problem areas; (iii) Action-oriented programs; and (iv) Periodic internal audits. (c... programs also include internal auditing and reporting systems as a means of measuring the contractor's... contents of affirmative action programs. 60-2.10 Section 60-2.10 Public Contracts and Property...

  6. NASULGC Council on Extension, Committee on Program Innovation and Action Oriented Research; 1968 Report. Part 1. Program Innovations. Part 2. Action Oriented Research.

    ERIC Educational Resources Information Center

    National Association of State Universities and Land Grant Colleges, Washington, DC.

    This report on extension activities of member institutions of the National Association of State Universities and Land Grant Colleges describes 91 program innovations and action oriented research activities. Objectives, sponsorship, program evaluations, and other data are cited for program innovations in such areas as continuing medical education,…

  7. The 3D Elevation Program initiative: a call for action

    USGS Publications Warehouse

    Sugarbaker, Larry J.; Constance, Eric W.; Heidemann, Hans Karl; Jason, Allyson L.; Lukas, Vicki; Saghy, David L.; Stoker, Jason M.

    2014-01-01

    The 3D Elevation Program (3DEP) initiative is accelerating the rate of three-dimensional (3D) elevation data collection in response to a call for action to address a wide range of urgent needs nationwide. It began in 2012 with the recommendation to collect (1) high-quality light detection and ranging (lidar) data for the conterminous United States (CONUS), Hawaii, and the U.S. territories and (2) interferometric synthetic aperture radar (ifsar) data for Alaska. Specifications were created for collecting 3D elevation data, and the data management and delivery systems are being modernized. The National Elevation Dataset (NED) will be completely refreshed with new elevation data products and services. The call for action requires broad support from a large partnership community committed to the achievement of national 3D elevation data coverage. The initiative is being led by the U.S. Geological Survey (USGS) and includes many partners—Federal agencies and State, Tribal, and local governments—who will work together to build on existing programs to complete the national collection of 3D elevation data in 8 years. Private sector firms, under contract to the Government, will continue to collect the data and provide essential technology solutions for the Government to manage and deliver these data and services. The 3DEP governance structure includes (1) an executive forum established in May 2013 to have oversight functions and (2) a multiagency coordinating committee based upon the committee structure already in place under the National Digital Elevation Program (NDEP). The 3DEP initiative is based on the results of the National Enhanced Elevation Assessment (NEEA) that was funded by NDEP agencies and completed in 2011. The study, led by the USGS, identified more than 600 requirements for enhanced (3D) elevation data to address mission-critical information requirements of 34 Federal agencies, all 50 States, and a sample of private sector companies and Tribal and local

  8. Action-oriented support for occupational safety and health programs in some developing countries in Asia.

    PubMed

    Kawakami, T; Kogi, K

    2001-01-01

    Action-oriented support programs have been increasingly playing vital roles in promoting safety and health in developing countries in Asia. This paper studied achievements of 3 action-oriented support programs: the WISE program for small enterprises, the WIND program for farmers, and the POSITIVE program for workers and trade unions. Special attention was paid to how the programs have strengthened local efforts for sustainable actions in safety and health improvements. The results showed that there were significant achievements in action-oriented support programs in the region, including a large number of improvement examples, integration into government policies, and network support through employers' and workers' organizations. Participatory, action-oriented training tools such as action-checklists, local good example photos, and group work methods played key roles in the effective implementation of the programs. It was of note that there were a number of local efforts to extend the coverage of action-oriented support even to hard-to-reach workers such as home-based workers, rural workers, and ethnic minorities. The efforts included the equal participation in the training by female and male farmers, shortened and weekend training programs, photo sheets showing local good examples, and reasonable fee collection for better sustainability. In conclusion, action-oriented support programs provided local people with concrete means to promote safety and health improvements. The successful programs commonly focused on local initiatives and were built on local wisdom and resources.

  9. 41 CFR 60-741.40 - General purpose and applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirement. (a) General purpose. An affirmative action program is a management tool designed to ensure equal... measurable objectives, quantitative analyses, and internal auditing and reporting systems that measure...

  10. Uranium Mill Tailings Remedial Action Program. Annual status report

    SciTech Connect

    Not Available

    1980-12-01

    The purpose, scope, history, requirements, and management organization of the UMTRA Program are summarized in the Introduction. The remainder of the report describes progress made during the past year (F 1980) and discusses future plants and activities. Early emphasis has been on the four highest-priority sites because of their proximity to population centers. These sites are: (1) Canonsburg, Pennsylvania; (2) Salt Lake City, Utah; (3) Durango, Colorado; and (4) Shiprock, New Mexico (Navajo Reservation). To date, twenty-five vicinity properties near the Canonsburg site and two such properties near the Salt Lake City site have been designated for remedial action. A research effort was undertaken at a major vicinity property, the Mountain States Supply Company in Salt Lake City, to study the effects of heating-and-ventilating-system modification on indoor radon-daughter concentrations. A cooperative agreement was executed between DOE and the Commonwealth of Pennsylvania. A similar agreement with the State of Utah is expected to be executed in early FY 1981. Further, it is expected that additional cooperative agreements will be negotiated during FY 1981 with the States of Colorado and Wyoming and the Navajo Nation. It is expected that the processing site at Canonsburg, PA (the Canonsburg Industrial Park) will be acquired during FY 1981. Draft Environmental Impact Statements for the four highest-priority sites will be completed during FY 1981.

  11. WSTF Propulsion and Pyrotechnics Corrective Action Test Program Status-2000

    NASA Technical Reports Server (NTRS)

    Saulsberry, R.; Ramirez, J.; Julien, H. L.; Hart, M.; Smith, W.; Bement, L.; Meagher, N. E.

    2000-01-01

    Extensive propulsion and pyrotechnic testing has been in progress at the NASA Johnson Space Center White Sands Test Facility (WSTF) since 1995. This started with the Mars Observer Propulsion and Pyrotechnics Corrective Action Test Program (MOCATP). The MOCATP has concluded, but extensive pyrovalve testing and research and development has continued at WSTF. The capability to accurately analyze and measure pyrovalve combustion product blow-by, evaluate propellant explosions initiated by blow-by, and characterize pyrovalve operation continues to be used and improved. This paper contains an overview of testing since MOCATP inception, but focuses on accomplishments since the status was last reported at the 35th Joint Propulsion Conference, June, 1999. This new activity includes evaluation of 3/8 inch Conax pyrovalves; development and testing of advanced pyrovalve technologies; investigation of nondestructive evaluation techniques to inspect pyrotechnically induced hydrazine explosions both through testing and modeling. Data from this collection of projects are now being formatted into a pyrovalve applications and testing handbook and consensus standard to benefit pyrovalve users and spacecraft designers. The handbook is briefly described here and in more detail in a separate paper. To increase project benefit, pyrovalve manufacturers are encouraged to provide additional valves for testing and consideration, and feedback is encouraged in all aspects of the pyrotechnic projects.

  12. Human Rap1 modulates TRF2 attraction to telomeric DNA

    PubMed Central

    Janoušková, Eliška; Nečasová, Ivona; Pavloušková, Jana; Zimmermann, Michal; Hluchý, Milan; Marini, Victoria; Nováková, Monika; Hofr, Ctirad

    2015-01-01

    More than two decades of genetic research have identified and assigned main biological functions of shelterin proteins that safeguard telomeres. However, a molecular mechanism of how each protein subunit contributes to the protecting function of the whole shelterin complex remains elusive. Human Repressor activator protein 1 (Rap1) forms a multifunctional complex with Telomeric Repeat binding Factor 2 (TRF2). Rap1–TRF2 complex is a critical part of shelterin as it suppresses homology-directed repair in Ku 70/80 heterodimer absence. To understand how Rap1 affects key functions of TRF2, we investigated full-length Rap1 binding to TRF2 and Rap1–TRF2 complex interactions with double-stranded DNA by quantitative biochemical approaches. We observed that Rap1 reduces the overall DNA duplex binding affinity of TRF2 but increases the selectivity of TRF2 to telomeric DNA. Additionally, we observed that Rap1 induces a partial release of TRF2 from DNA duplex. The improved TRF2 selectivity to telomeric DNA is caused by less pronounced electrostatic attractions between TRF2 and DNA in Rap1 presence. Thus, Rap1 prompts more accurate and selective TRF2 recognition of telomeric DNA and TRF2 localization on single/double-strand DNA junctions. These quantitative functional studies contribute to the understanding of the selective recognition of telomeric DNA by the whole shelterin complex. PMID:25675958

  13. Rap G protein signal in normal and disordered lymphohematopoiesis.

    PubMed

    Minato, Nagahiro

    2013-09-10

    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the development and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy.

  14. Rap G protein signal in normal and disordered lymphohematopoiesis

    SciTech Connect

    Minato, Nagahiro

    2013-09-10

    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the development and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy.

  15. Making Tracks 1.0: Action Researching an Active Transportation Education Program

    ERIC Educational Resources Information Center

    Robinson, Daniel; Foran, Andrew; Robinson, Ingrid

    2014-01-01

    This paper reports on the results of the first cycle of an action research project. The objective of this action research was to examine the implementation of a school-based active transportation education program (Making Tracks). A two-cycle action research design was employed in which elementary school students' (ages 7-9), middle school…

  16. Department Raps States on Testing

    ERIC Educational Resources Information Center

    Olson, Lynn

    2006-01-01

    The U.S. Department of Education has notified 10 states that it intends to withhold a portion of their state administrative funds under the Title I program for failing to comply fully with the testing provisions of the No Child Left Behind Act by the end of the 2005-06 school year. Those funds would instead be diverted directly to school…

  17. The "RAP" on Reading Comprehension

    ERIC Educational Resources Information Center

    Hagaman, Jessica L.; Luschen, Kati; Reid, Robert

    2010-01-01

    Reading problems are one of the most frequent reasons students are referred for special education services and the disparity between students with reading difficulties and those who read successfully appears to be increasing. As a result, there is now an emphasis on early intervention programs such as RTI. In many cases, early intervention in…

  18. Building a Knowledge to Action Program in Stroke Rehabilitation.

    PubMed

    Janzen, Shannon; McIntyre, Amanda; Richardson, Marina; Britt, Eileen; Teasell, Robert

    2016-09-01

    The knowledge to action (KTA) process proposed by Graham et al (2006) is a framework to facilitate the development and application of research evidence into clinical practice. The KTA process consists of the knowledge creation cycle and the action cycle. The Evidence Based Review of Stroke Rehabilitation is a foundational part of the knowledge creation cycle and has helped guide the development of best practice recommendations in stroke. The Rehabilitation Knowledge to Action Project is an audit-feedback process for the clinical implementation of best practice guidelines, which follows the action cycle. The objective of this review was to: (1) contextualize the Evidence Based Review of Stroke Rehabilitation and Rehabilitation Knowledge to Action Project within the KTA model and (2) show how this process led to improved evidence-based practice in stroke rehabilitation. Through this process, a single centre was able to change clinical practice and promote a culture that supports the use of evidence-based practices in stroke rehabilitation.

  19. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE... Development, Rehabilitation and Innovation § 72.43 Fundable elements: Recovery Action Program...

  20. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE... Development, Rehabilitation and Innovation § 72.43 Fundable elements: Recovery Action Program...

  1. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE... Development, Rehabilitation and Innovation § 72.43 Fundable elements: Recovery Action Program...

  2. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Additional required elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... management to ensure the effective implementation of the affirmative action program. (b) Identification...

  3. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false General purpose and contents of affirmative action programs. 60-2.10 Section 60-2.10 Public Contracts and Property Management...) An affirmative action program is a management tool designed to ensure equal employment opportunity....

  4. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Additional required elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... management to ensure the effective implementation of the affirmative action program. (b) Identification...

  5. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE... Development, Rehabilitation and Innovation § 72.43 Fundable elements: Recovery Action Program...

  6. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE... Development, Rehabilitation and Innovation § 72.43 Fundable elements: Recovery Action Program...

  7. A Relevant War Against Poverty. A Study of Community Action Programs and Observable Social Change.

    ERIC Educational Resources Information Center

    Clark, Kenneth B.; Hopkins, Jeannette

    Twelve urban community action programs (CAP) were examined in depth to determine how each of them operationally defined community action and to evaluate their performance. The criteria used were: (1) a clear statement of purpose and programs consistent with that purpose; (2) strong independent leadership and a built-in evaluation and…

  8. 36 CFR 72.17 - Preliminary Action Program-commitments to be included.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Preliminary Action Program-commitments to be included. 72.17 Section 72.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs §...

  9. The Data-to-Action Framework: A Rapid Program Improvement Process

    ERIC Educational Resources Information Center

    Zakocs, Ronda; Hill, Jessica A.; Brown, Pamela; Wheaton, Jocelyn; Freire, Kimberley E.

    2015-01-01

    Although health education programs may benefit from quality improvement methods, scant resources exist to help practitioners apply these methods for program improvement. The purpose of this article is to describe the Data-to-Action framework, a process that guides practitioners through rapid-feedback cycles in order to generate actionable data to…

  10. Flight calibration assessment of HiRAP accelerometer data

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Larman, Kevin T.; Moast, Christina D.

    1993-01-01

    A flight derived method of calibrating the High Resolution Accelerometer Package (HiRAP) flight data has been developed and is discussed for Shuttle Orbiter missions STS-35 and STS-40. These two mission data sets have been analyzed using ground calibration factors and flight derived calibration factors. This flight technique evolved early in the flight program when it was recognized that ground calibration factors are insufficient to determine absolute low-acceleration levels. The application of flight calibration factors to the data sets from these missions produced calibrated acceleration levels within an accuracy of less than +/- 1.5 microgravity of zero during a time in the flight when the acceleration level was known to be less than 1.0 microgravity. This analysis further confirms the theory that flight calibrations are required in order to obtain the absolute measurement of low-frequency, low-acceleration flight signals.

  11. Helping Migrant and Seasonal Farm Worker Families. Annual Report 1971 [Migrant Action Program, Mason City, Iowa].

    ERIC Educational Resources Information Center

    Migrant Action Program, Mason City, IA.

    The objective of the Migrant Action Program (MAP) in Iowa is to assist the migrant and seasonal farm workers and their families. This 1971 annual report cntains a description of the program goals and activities, including the Manpower Project, children's programs, day care, vehicle purchase and use, the health program, and emergency food…

  12. Rap Music Literacy: A Case Study of Millennial Audience Reception to Rap Lyrics Depicting Independent Women

    ERIC Educational Resources Information Center

    Moody-Ramirez, Mia; Scott, Lakia M.

    2015-01-01

    Using a feminist lens and a constructivist approach as the theoretical framework, we used rap lyrics and videos to help college students explore mass media's representation of the "independent" Black woman and the concept of "independence" in general. Students must be able to formulate their own concept of independence to…

  13. Teacher Performance Pay Programs and Necessary Communication Actions

    ERIC Educational Resources Information Center

    Heneman, Herbert G., III; Worth, Robin; Arrigoni, Jessica; Kimball, Steven M.; Milanowski, Anthony

    2013-01-01

    Teacher performance pay programs have proliferated across the country over the past 20 years. To aid in understanding their many variations, the seven major components of these programs are described. Three examples of teacher performance pay programs are provided for illustration: Denver ProComp, TAP, and Houston ASPIRE. Evidence is mixed on the…

  14. Listening to Rap: Cultures of Crime, Cultures of Resistance

    ERIC Educational Resources Information Center

    Tanner, Julian; Asbridge, Mark; Wortley, Scot

    2009-01-01

    This research compares representations of rap music with the self-reported criminal behavior and resistant attitudes of the music's core audience. Our database is a large sample of Toronto high school students (n = 3,393) from which we identify a group of listeners, whose combination of musical likes and dislikes distinguish them as rap univores.…

  15. Fiscal Year 2013 Trails Management Program Mitigation Action Plan Annual Report, October 2013

    SciTech Connect

    Pava, Daniel S.

    2015-03-25

    This Trails Management Program Mitigation Action Plan Annual Report (Trails MAPAR) has been prepared for the Department of Energy (DOE)/National Nuclear Security Administration (NNSA) as part of implementing the 2003 Final Environmental Assessment for the Proposed Los Alamos National Laboratory Trails Management Program (DOE 2003). The Trails Mitigation Action Plan (MAP) is now a part of the Site-Wide Environmental Impact Statement for the Continued Operation of Los Alamos National Laboratory (DOE/EIS 0380) Mitigation Action Plan (2008 SWEIS MAP) (DOE 2008). The MAP provides guidance for the continued implementation of the Trails Management Program at Los Alamos National Laboratory (LANL) and integration of future mitigation actions into the 2008 SWEIS MAP to decrease impacts associated with recreational trails use at LANL. This eighth MAPAR includes a summary of Trails Management Program activities and actions during Fiscal Year (FY) 2013, from October 2012 through September 2013.

  16. Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 12. Environmental Restoration Program

    SciTech Connect

    Not Available

    1991-09-01

    The 664 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions constitute the twelfth in a series of reports prepared annually for the US Department of Energy Remedial Action Programs. Citations to foreign and domestic literature of all types -- technical reports, progress reports, journal articles, symposia proceedings, theses, books, patents, legislation, and research project descriptions -- have been included. The bibliography contains scientific, technical, economic, regulatory, and legal information pertinent to the US Department of Energy Remedial Action Programs. Major sections are (1) Decontamination and Decommissioning Program, (2) Nuclear Facilities Decommissioning, (3) Formerly Utilized Sites Remedial Action Program, (4) Facilities Contaminated with Naturally Occurring Radionuclides, (5) Uranium Mill Tailings Remedial Action Program, (6) Uranium Mill Tailings Management, (7) Technical Measurements Center, and (8) Environmental Restoration Program. Within these categories, references are arranged alphabetically by first author. Those references having no individual author are listed by corporate affiliation or by publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word. This report is a product of the Remedial Action Program Information Center (RAPIC), which selects, analyzes, and disseminates information on environmental restoration and remedial actions. RAPIC staff and resources are available to meet a variety of information needs. Contact the center at FTS 624-7764 or (615) 574-7764.

  17. Using Action Research to Engage Youth in Improving OST Programming

    ERIC Educational Resources Information Center

    Hubbard, Brian

    2015-01-01

    Youth are often portrayed as apathetic, uninvolved, and reluctant to participate in their communities (Baizerman, Hildreth, & Roholt, 2013). Ironically, however, communities offer few opportunities for youth to address issues that are compelling to their interests and that engage their commitment and action (Bradford & Cullen, 2012;…

  18. Effectiveness of Mentoring Program Practices. Research in Action. Issue 2

    ERIC Educational Resources Information Center

    DuBois, David L.

    2007-01-01

    This article focuses on mentoring program practices in relation to issues of effectiveness, while recognizing that implications for program quality conceptualized more broadly is a key concern in need of greater investigation. The author provides an overview of selected conceptual and methodological issues involved with identification of…

  19. Granite School District's Comprehensive Counseling and Guidance Program in Action.

    ERIC Educational Resources Information Center

    Petersen, Judy

    This paper discusses the development of the Utah Model for Comprehensive Counseling and Guidance, and specifically, its application in the Granite School Districts Guidance Program. This model adopted the National Occupational Information Coordinating Committee (NOICC) competencies as its desired program content, which focuses on student outcomes.…

  20. YES in Action: Youth Environmental Service Program Summary.

    ERIC Educational Resources Information Center

    Office of Juvenile Justice and Delinquent Prevention (Dept. of Justice), Washington, DC.

    The Youth Environmental Service (YES) aims to rehabilitate adjudicated delinquents and to prevent at-risk youth from entering the juvenile justice system by engaging them in environmental work and education programs on federally owned land. YES is a joint program of the U.S. Department of the Interior (DOI) and the Office of Juvenile Justice and…

  1. Rap Music Genres and Deviant Behaviors in French-Canadian Adolescents

    ERIC Educational Resources Information Center

    Miranda, Dave; Claes, Michel

    2004-01-01

    This study investigated the links between the preference for 4 rap music genres (American rap, French rap, hip hop/soul, and gangsta/hardcore rap) and 5 types of deviant behaviors in adolescence (violence, theft, street gangs, mild drug use, and hard drug use). The effects of peers' deviancy, violent media, and importance given to lyrics were…

  2. PLAN Bicol, Philippines: health manpower development program in action.

    PubMed

    Lind, K

    1994-06-01

    PLAN Bicol in the Philippines is a community based Health Manpower Development Program (HMDP) geared toward training and mobilization of indigenous health practitioners, providing infrastructural and logistical support to individual families, and educating the community about health, nutrition, and the environment. The field officer recommends at the initiation of a project that program staff have roles that are well defined. New programs should be introduced to the community first and should involve the community in the planning stages. The HMDP program is directed to 38 villages located around national parks that have suffered from deforestation. Community health issues are malnutrition, low immunization, and lack of access to health services. HMDP established a training program for auxiliary health workers (AHWs), who make a commitment to return to their villages after training. Midwives are being trained at local schools. Village houses are being built and repaired; water systems and sanitary toilet facilities are being installed. Village health stations have been constructed and equipped with basic medicines, supplies, and equipment, and are open 5 days a week. Health education classes inform the community about nutrition and health. The problems at inception were the unwillingness of field staff to participate in the program and a high drop out rate among AHWs. Problems were worked out as the program progressed. Facilitative factors are the close coordination with the provincial health office, community acceptance, and the availability of qualified people.

  3. Photometric redshift estimation based on data mining with PhotoRApToR

    NASA Astrophysics Data System (ADS)

    Cavuoti, S.; Brescia, M.; De Stefano, V.; Longo, G.

    2015-03-01

    Photometric redshifts (photo-z) are crucial to the scientific exploitation of modern panchromatic digital surveys. In this paper we present PhotoRApToR (Photometric Research Application To Redshift): a Java/C ++ based desktop application capable to solve non-linear regression and multi-variate classification problems, in particular specialized for photo-z estimation. It embeds a machine learning algorithm, namely a multi-layer neural network trained by the Quasi Newton learning rule, and special tools dedicated to pre- and post-processing data. PhotoRApToR has been successfully tested on several scientific cases. The application is available for free download from the DAME Program web site.

  4. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for Management of Uranium Byproduct Materials Pursuant to Section 84 of the Atomic Energy Act of 1954, as...

  5. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for Management of Uranium Byproduct Materials Pursuant to Section 84 of the Atomic Energy Act of 1954, as...

  6. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for Management of Uranium Byproduct Materials Pursuant to Section 84 of the Atomic Energy Act of 1954, as...

  7. Project L.O.S.T.: A "Grass Roots" Environmental Action Program by High School Students

    ERIC Educational Resources Information Center

    Hoban, Tana M.

    1977-01-01

    Divided into departments focusing on water analysis, marine studies, wildlife studies, and air analysis, Project Laboratory of Scientific Testing (LOST) is an exemplary ecological action program initiated by teenagers and furthered by community participation in Ithaca, New York. (JC)

  8. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246, as..., as amended, and its implementing regulations, including 41 CFR part 60-2 (Revised Order 4), will...

  9. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246, as..., as amended, and its implementing regulations, including 41 CFR part 60-2 (Revised Order 4), will...

  10. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246, as..., as amended, and its implementing regulations, including 41 CFR part 60-2 (Revised Order 4), will...

  11. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246, as..., as amended, and its implementing regulations, including 41 CFR part 60-2 (Revised Order 4), will...

  12. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246, as..., as amended, and its implementing regulations, including 41 CFR part 60-2 (Revised Order 4), will...

  13. Affirmative Action. Module Number 16. Work Experience Program Modules. Coordination Techniques Series.

    ERIC Educational Resources Information Center

    Shawhan, Carl; Morley, Ray

    This self-instructional module, the last in a series of 16 on techniques for coordinating work experience programs, deals with affirmative action. Addressed in the module are the following topics: the nature of affirmative action legislation and regulations, the role of the teacher-coordinator as a resource person for affirmative action…

  14. 40 CFR 258.58 - Implementation of the corrective action program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Ground-Water Monitoring and Corrective...) Establish and implement a corrective action ground-water monitoring program that: (i) At a minimum, meet the... corrective action remedy; and (iii) Demonstrate compliance with ground-water protection standard pursuant...

  15. 40 CFR 258.58 - Implementation of the corrective action program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Ground-Water Monitoring and Corrective...) Establish and implement a corrective action ground-water monitoring program that: (i) At a minimum, meet the... corrective action remedy; and (iii) Demonstrate compliance with ground-water protection standard pursuant...

  16. 40 CFR 257.28 - Implementation of the corrective action program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... environmental receptors to hazardous constituents; (iii) Actual or potential contamination of drinking water...-Municipal Non-Hazardous Waste Disposal Units Ground-Water Monitoring and Corrective Action § 257.28... corrective action ground-water monitoring program that: (i) At a minimum, meets the requirements of...

  17. 40 CFR 257.28 - Implementation of the corrective action program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... environmental receptors to hazardous constituents; (iii) Actual or potential contamination of drinking water...-Municipal Non-Hazardous Waste Disposal Units Ground-Water Monitoring and Corrective Action § 257.28... corrective action ground-water monitoring program that: (i) At a minimum, meets the requirements of...

  18. 78 FR 11903 - Acceptability of Corrective Action Programs for Fuel Cycle Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... COMMISSION Acceptability of Corrective Action Programs for Fuel Cycle Facilities AGENCY: Nuclear Regulatory... Fuel Cycle Facilities.'' The draft NUREG provides guidance to the NRC staff on how to determine whether a Corrective Action Plan (CAP) submitted by the licensee of a fuel cycle facility is...

  19. Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier

    PubMed Central

    DiStefano, Peter V.; Smrcka, Alan V.; Glading, Angela J.

    2016-01-01

    The phosphoinositide-specific phospholipase C, PLCε, is a unique signaling protein with known roles in regulating cardiac myocyte growth, astrocyte inflammatory signaling, and tumor formation. PLCε is also expressed in endothelial cells, however its role in endothelial regulation is not fully established. We show that endothelial cells of multiple origins, including human pulmonary artery (HPAEC), human umbilical vein (HUVEC), and immortalized brain microvascular (hCMEC/D3) endothelial cells, express PLCε. Knockdown of PLCε in arterial endothelial monolayers decreased the effectiveness of the endothelial barrier. Concomitantly, RhoA activity and stress fiber formation were increased. PLCε-deficient arterial endothelial cells also exhibited decreased Rap1-GTP levels, which could be restored by activation of the Rap1 GEF, Epac, to rescue the increase in monolayer leak. Reintroduction of PLCε rescued monolayer leak with both the CDC25 GEF domain and the lipase domain of PLCε required to fully activate Rap1 and to rescue endothelial barrier function. Finally, we demonstrate that the barrier promoting effects PLCε are dependent on Rap1 signaling through the Rap1 effector, KRIT1, which we have previously shown is vital for maintaining endothelial barrier stability. Thus we have described a novel role for PLCε PIP2 hydrolytic and Rap GEF activities in arterial endothelial cells, where PLCε-dependent activation of Rap1/KRIT1 signaling promotes endothelial barrier stability. PMID:27612188

  20. Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.

    PubMed

    DiStefano, Peter V; Smrcka, Alan V; Glading, Angela J

    2016-01-01

    The phosphoinositide-specific phospholipase C, PLCε, is a unique signaling protein with known roles in regulating cardiac myocyte growth, astrocyte inflammatory signaling, and tumor formation. PLCε is also expressed in endothelial cells, however its role in endothelial regulation is not fully established. We show that endothelial cells of multiple origins, including human pulmonary artery (HPAEC), human umbilical vein (HUVEC), and immortalized brain microvascular (hCMEC/D3) endothelial cells, express PLCε. Knockdown of PLCε in arterial endothelial monolayers decreased the effectiveness of the endothelial barrier. Concomitantly, RhoA activity and stress fiber formation were increased. PLCε-deficient arterial endothelial cells also exhibited decreased Rap1-GTP levels, which could be restored by activation of the Rap1 GEF, Epac, to rescue the increase in monolayer leak. Reintroduction of PLCε rescued monolayer leak with both the CDC25 GEF domain and the lipase domain of PLCε required to fully activate Rap1 and to rescue endothelial barrier function. Finally, we demonstrate that the barrier promoting effects PLCε are dependent on Rap1 signaling through the Rap1 effector, KRIT1, which we have previously shown is vital for maintaining endothelial barrier stability. Thus we have described a novel role for PLCε PIP2 hydrolytic and Rap GEF activities in arterial endothelial cells, where PLCε-dependent activation of Rap1/KRIT1 signaling promotes endothelial barrier stability. PMID:27612188

  1. Action!

    ERIC Educational Resources Information Center

    Senese, Joseph

    1998-01-01

    A small group of teachers at one Illinois high school is helping to effect and promote change. Through the Action Research Laboratory (ARL), teams of teachers conduct collaborative action research to improve classroom practices. Data from the first two years of the ARL indicate that teachers are eager to participate in, and have thrived in, their…

  2. Bellingham Bay action program: Initial data summaries and problem identification

    SciTech Connect

    Decker, D.S.; Sonnerup, R.; Greene, J.J.

    1989-08-01

    The report provides a synthesis of information describing the geographic extent and severity of estuarine contamination in Bellingham Bay within Puget Sound in Washington State. Summaries of existing data are provided for chemical contamination of sediment and biota, microbial contamination, eutrophication and contaminant sources. Original, summarized, tabulated, and mapped data are presented. The objective of the report is to provide a mechanism for comprehensively evaluating pollution problems in the more urbanized embayments and for providing a basis for prioritizing corrective actions. A decision making framework is presented for evaluating and prioritizing both sub-areas within Bellingham Bay and specific contaminant sources.

  3. Afterschool in Action: Innovative Afterschool Programs Supporting Middle School Youth

    ERIC Educational Resources Information Center

    Afterschool Alliance, 2013

    2013-01-01

    The Afterschool Alliance and MetLife Foundation are proud to celebrate a fifth round of the MetLife Foundation Afterschool Innovator Awards. For the past five years, we have collaborated to highlight the work of quality afterschool programs that support children, families and communities across the nation. This compendium is a compilation of four…

  4. The Federal Art Project: Holger Cahill's Program of Action.

    ERIC Educational Resources Information Center

    Mavigliano, George J.

    1984-01-01

    Under the directorship of Holger Cahill, who drew upon John Dewey's principle of the universal communicability of art, the Federal Art Project of the Great Depression era gave all of the people the opportunity to study and enjoy art. Specific programs of the project are described. (RM)

  5. Evaluating Alternative High Schools: Program Evaluation in Action

    ERIC Educational Resources Information Center

    Hinds, Drew Samuel Wayne

    2013-01-01

    Alternative high schools serve some of the most vulnerable students and their programs present a significant challenge to evaluate. Determining the impact of an alternative high school that serves mostly at-risk students presented a significant research problem. Few studies exist that dig deeper into the characteristics and strategies of…

  6. Technology needs for environmental restoration remedial action. Environmental Restoration Program

    SciTech Connect

    Watson, J.S.

    1992-11-01

    This report summarizes the current view of the most important technology needs for the US Department of Energy (DOE) facilities operated by Martin Marietta Energy Systems, Inc. These facilities are the Oak Ridge National Laboratory, the Oak Ridge K-25 Site, the Oak Ridge Y-12 Plant, the Paducah Gaseous Diffusion Plant, and the Portsmouth Gaseous Diffusion Plant. The sources of information used in this assessment were a survey of selected representatives of the Environmental Restoration (ER) programs at each facility, results from a questionnaire distributed by Geotech CWM, Inc., for DOE, and associated discussions with individuals from each facility. This is not a final assessment, but a brief look at an ongoing assessment; the needs will change as the plans for restoration change and, it is hoped, as some technical problems are solved through successful development programs.

  7. Programming for safe motherhood: a guide to action.

    PubMed

    Koblinsky, M A; Tinker, A; Daly, P

    1994-09-01

    The Safe Motherhood Initiative has successfully stimulated much interest in reducing maternal mortality. To accelerate programme implementation, this paper reviews lessons learned from the experience of industrial countries and from demonstration projects in developing countries, and proposes intervention strategies of policy dialogue, improved services and behavioural change. A typological approach with three hypothetical settings from resource poor to resource rich environments is used to address the variability in health behaviours and infrastructure encountered when programming for safe motherhood.

  8. How Young Children Learn to Program with Sensor, Action, and Logic Blocks

    ERIC Educational Resources Information Center

    Wyeth, Peta

    2008-01-01

    Electronic Blocks are a new programming environment designed specifically for children aged between 3 and 8 years. These physical, stackable blocks include sensor blocks, action blocks, and logic blocks. By connecting these blocks, children can program a wide variety of structures that interact with one another and the environment. Electronic…

  9. The Evaluation of an Early Childhood Teacher Preparation Program: An Action Research Project

    ERIC Educational Resources Information Center

    Ragno, Kerry Sullivan

    2013-01-01

    The purpose of this dissertation was to evaluate the effectiveness of an Early Childhood Development Associate of Applied Science (AAS) degree program at one community college as part of an ongoing action research project. Prior to this dissertation study, external and internal barriers prevented the associate degree program stakeholders from…

  10. National Clearinghouse for Drug Abuse Information Report Series, Series 22, No. 1. Community Action Programs.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Based on the principle that drug abuse is no longer a problem restricted to certain economic, social, educational, or intellectual levels or ethnic groups, this pamphlet relates some examples of on-going community action programs and projects. Essentially, these programs are striving to solve some of the drug related problems in their immediate…

  11. Affirmative Action Strategies and Professional Schools: Case Illustrations of Exemplary Programs.

    ERIC Educational Resources Information Center

    Twale, Darla J.; And Others

    Seven case illustrations of affirmative action (AFA) programs are presented. Increases in the numbers of women and minority students at professional schools have been reported, but disadvantaged populations still suffer underrepresentation. The literature indicates that effective AFA may be realized through: early identification programs and…

  12. PROGRAM TO TRAIN TRADE UNIONISTS AND CAA STAFF WORKERS AS COMMUNITY ACTION TRAINERS, CURRICULUM AND SCHEDULE.

    ERIC Educational Resources Information Center

    EIGER, NORMAN

    OBJECTIVES OF THE TEN-DAY RESIDENTIAL TRAINING PROGRAM HELD IN JUNE 1967 WERE--TO UNDERSTAND THE ROLE OF THE TRAINER, TO DEVELOP SKILLS AND KNOWLEDGE IN WORKING WITH GROUPS AND IN IMPLEMENTING COMMUNITY ACTION TRAINING PROGRAMS, TO HEIGHTEN SELF-AWARENESS, TO LEARN TO APPLY FORCE FIELD ANALYSIS TO PROBLEM SOLVING, TO INTERPRET LABOR'S POSITION IN…

  13. Using Work Action Analysis to Identify Web-Portal Requirements for a Professional Development Program

    ERIC Educational Resources Information Center

    Nickles, George

    2007-01-01

    This article describes using Work Action Analysis (WAA) as a method for identifying requirements for a web-based portal that supports a professional development program. WAA is a cognitive systems engineering method for modeling multi-agent systems to support design and evaluation. A WAA model of the professional development program of the…

  14. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) An affirmative action program is a management tool designed to ensure equal employment opportunity. A... programs also include internal auditing and reporting systems as a means of measuring the contractor's... perspective, as a powerful management tool, there is a positive correlation between the presence...

  15. Implementing Experiential Action Learning in International Management Education: The Global Business Strategic (GLOBUSTRAT) Consulting Program

    ERIC Educational Resources Information Center

    Kamath, Shyam; Agrawal, Jagdish; Krickx, Guido

    2008-01-01

    This paper discusses the theoretical foundations and implementation challenges and outcomes of a unique "hands-on" global consulting program that is integrated into an international EMBA program for mid-career and senior American and European managers. It details the challenges for the integration of experiential action learning, double-loop…

  16. Optimization of the rapping process of an intermittent electrostatic precipitator

    NASA Astrophysics Data System (ADS)

    Miloua, F.; Tilmatine, A.; Gouri, R.; Kadous, N.; Dascalescu, L.

    2008-01-01

    Intermittent operation mode is specific to electrostatic precipitators (ESP) used in workshops where the polluting product is produced in a discontinuous way. The rapping system is necessary in order to ensure a continuous and effective operation of a dry electrostatic precipitator, but causes at the same time, a problem of re-entrainment of dust and thus the degradation of filtration efficiency. The objective of this paper is to propose a procedure based on the methodology of experimental designs (Tagushi's Methodology) aiming at optimizing the rapping process; it consists to determine optimal values of rapping, i.e. the moment, the position and the force of rapping. Several “one-factor-at-a-time" experimental designs followed by a Full Factorial design, made it possible to model the process and to analyze interactions between the factors. The experiments were carried out on a laboratory experimental device which simulates an industrial precipitator with intermittent operation.

  17. Chaperone-mediated specificity in Ras and Rap signaling.

    PubMed

    Azoulay-Alfaguter, Inbar; Strazza, Marianne; Mor, Adam

    2015-01-01

    Ras and Rap proteins are closely related small guanosine triphosphatase (GTPases) that share similar effector-binding domains but operate in a very different signaling networks; Ras has a dominant role in cell proliferation, while Rap mediates cell adhesion. Ras and Rap proteins are regulated by several shared processes such as post-translational modification, phosphorylation, activation by guanine exchange factors and inhibition by GTPase-activating proteins. Sub-cellular localization and trafficking of these proteins to and from the plasma membrane are additional important regulatory features that impact small GTPases function. Despite its importance, the trafficking mechanisms of Ras and Rap proteins are not completely understood. Chaperone proteins play a critical role in trafficking of GTPases and will be the focus of the discussion in this work. We will review several aspects of chaperone biology focusing on specificity toward particular members of the small GTPase family. Understanding this specificity should provide key insights into drug development targeting individual small GTPases.

  18. 78 FR 43091 - Technical Operations Safety Action Program (T-SAP) and Air Traffic Safety Action Program (ATSAP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-19

    ... from public disclosure under 14 CFR part 193. 3. Overview a. Qualified Participants. Technical... submitted by a qualified participant under the T-SAP or ATSAP, that is accepted into either program... Participate. Individuals who are qualified participants register for, and submit a report into, the...

  19. Program overview: Remedial actions at Oak Ridge National Laboratory

    SciTech Connect

    Bates, L.D.; Trabalka, J.R.

    1988-07-27

    Research on and development of civilian and defense uses of nuclear materials and technologies have occurred at Oak Ridge National Laboratory (ORNL) since its creation as part of the World War II Manhattan Project in 1943. A diverse legacy of contaminated inactive facilities, research areas, and waste management areas exists; many are candidates for remedial action. Most attention is focused on waste management sites which contain the bulk of ORNL's environmental contamination. A wide variety of liquid and solid wastes, primarily radioactive wastes or mixed wastes in which radioactivity was the principal hazardous constituent, have been disposed of on-site in the past 45 years. One potential approach to remedial problems at ORNL is to design primarily for control and decay in situ (during an institutional control period of 100 years or more) of intermediate-lived wastes such as /sup 3/H, /sup 90/Sr, and /sup 137/Cs. Passive measures designed to provide greater long-term confinement (for example, in situ vitrification) could be exercised at sites contaminated with TRU wastes or high concentrations of hazardous constitutes. This approach would (a) provide a period sufficiently long for evaluation of the effectiveness of environmental processes and passive remedial measures in controlling the migration of long-lived materials, (b) allow additional time needed for development of new technologies for more permanent site stabilization, and (c) reduce the need for immediate implementation of the more-expensive exhumation and disposal option.

  20. Radiological assistance program: Region I. Part I

    SciTech Connect

    Musolino, S.V.; Kuehner, A.V.; Hull, A.P.

    1985-07-15

    The purpose of the Radiological Assistance Program (RAP) is to make DOE resources available and provide emergency assistance to state and local agencies in order to control radiological hazards, protect the public health and safety, and minimize the loss of property. This plan is an integral part of a nationwide program of radiological assistance established by the US DOE, and is implemented on a regional basis. The Brookhaven Area Office (BHO) Radiological Assistance Program is applicable to DOE Region I, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia. The BHO RAP-1 has been developed to: (a) ensure the availability of an effective radiological assistance capability to ensure the protection of persons and property; (b) provide guidelines to RAP-1 Team personnel for the evaluation of radiological incidents and implementation of corrective actions; (c) maintain liaison with other DOE installations, Federal, State and local organizations which may become involved in radiological assistance operations in Region I; and (d) encourage development of a local capability to cope with radiological incidents.

  1. RAP1 GTPase Overexpression is Associated with Cervical Intraepithelial Neoplasia

    PubMed Central

    Pascoal-Xavier, Marcelo Antonio; Figueiredo, Anna Carolina Cançado; Gomes, Luciana Inácia; Peruhype-Magalhães, Vanessa; Calzavara-Silva, Carlos Eduardo; Costa, Marcelo Azevedo; Reis, Ilka Afonso; Bonjardim, Claudio Antônio; Kroon, Erna Geessien

    2015-01-01

    RAP1 (RAS proximate 1), a small GTP-binding protein of the RAS superfamily, is a putative oncogene that is highly expressed in several malignant cell lines and types of cancers, including some types of squamous cell carcinoma. However, the participation of RAP1 in cervical carcinogenesis is unknown. We conducted a cross-sectional study of paraffin-embedded cervical biopsies to determine the association of RAP1 with cervical intraepithelial neoplasia (CIN). Standard and quantitative immunohistochemistry assessment of RAP1 expression in fixed tissue was performed on 183 paraffin-embedded cervical biopsies that were classified as normal or non-dysplastic mucosa (NDM) (n = 33); CIN grade 1 (n = 84) and CIN grade 2/3 (n = 66). A gradual increase in RAP1 expression in NDM < CIN 1 < CIN 2/3 (p<0.001) specimens was observed and was in agreement with the histopathologic diagnosis. A progressive increase in the RAP1 expression levels increased the risk of CIN 1 [odds ratio (OR) = 3.50; 95% confidence interval (CI) 1.30-10.64] 3.5 fold and the risk of CIN 2/3 (OR = 19.86, 95% CI 6.40-70.79) nearly 20 fold when compared to NDM. In addition, stereotype ordinal regression analysis showed that this progressive increase in RAP1 expression more strongly impacted CIN 2/3 than CIN 1. Our findings suggest that RAP1 may be a useful biomarker for the diagnosis of CIN. PMID:25856570

  2. Mutations in CDK5RAP2 cause Seckel syndrome

    PubMed Central

    Yigit, Gökhan; Brown, Karen E; Kayserili, Hülya; Pohl, Esther; Caliebe, Almuth; Zahnleiter, Diana; Rosser, Elisabeth; Bögershausen, Nina; Uyguner, Zehra Oya; Altunoglu, Umut; Nürnberg, Gudrun; Nürnberg, Peter; Rauch, Anita; Li, Yun; Thiel, Christian Thomas; Wollnik, Bernd

    2015-01-01

    Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal proportionate short stature, severe microcephaly, intellectual disability, and characteristic facial features. Here, we describe the novel homozygous splice-site mutations c.383+1G>C and c.4005-9A>G in CDK5RAP2 in two consanguineous families with Seckel syndrome. CDK5RAP2 (CEP215) encodes a centrosomal protein which is known to be essential for centrosomal cohesion and proper spindle formation and has been shown to be causally involved in autosomal recessive primary microcephaly. We establish CDK5RAP2 as a disease-causing gene for Seckel syndrome and show that loss of functional CDK5RAP2 leads to severe defects in mitosis and spindle organization, resulting in cells with abnormal nuclei and centrosomal pattern, which underlines the important role of centrosomal and mitotic proteins in the pathogenesis of the disease. Additionally, we present an intriguing case of possible digenic inheritance in Seckel syndrome: A severely affected child of nonconsanguineous German parents was found to carry heterozygous mutations in CDK5RAP2 and CEP152. This finding points toward a potential additive genetic effect of mutations in CDK5RAP2 and CEP152. PMID:26436113

  3. Mutations in CDK5RAP2 cause Seckel syndrome.

    PubMed

    Yigit, Gökhan; Brown, Karen E; Kayserili, Hülya; Pohl, Esther; Caliebe, Almuth; Zahnleiter, Diana; Rosser, Elisabeth; Bögershausen, Nina; Uyguner, Zehra Oya; Altunoglu, Umut; Nürnberg, Gudrun; Nürnberg, Peter; Rauch, Anita; Li, Yun; Thiel, Christian Thomas; Wollnik, Bernd

    2015-09-01

    Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal proportionate short stature, severe microcephaly, intellectual disability, and characteristic facial features. Here, we describe the novel homozygous splice-site mutations c.383+1G>C and c.4005-9A>G in CDK5RAP2 in two consanguineous families with Seckel syndrome. CDK5RAP2 (CEP215) encodes a centrosomal protein which is known to be essential for centrosomal cohesion and proper spindle formation and has been shown to be causally involved in autosomal recessive primary microcephaly. We establish CDK5RAP2 as a disease-causing gene for Seckel syndrome and show that loss of functional CDK5RAP2 leads to severe defects in mitosis and spindle organization, resulting in cells with abnormal nuclei and centrosomal pattern, which underlines the important role of centrosomal and mitotic proteins in the pathogenesis of the disease. Additionally, we present an intriguing case of possible digenic inheritance in Seckel syndrome: A severely affected child of nonconsanguineous German parents was found to carry heterozygous mutations in CDK5RAP2 and CEP152. This finding points toward a potential additive genetic effect of mutations in CDK5RAP2 and CEP152.

  4. Mutations in CDK5RAP2 cause Seckel syndrome.

    PubMed

    Yigit, Gökhan; Brown, Karen E; Kayserili, Hülya; Pohl, Esther; Caliebe, Almuth; Zahnleiter, Diana; Rosser, Elisabeth; Bögershausen, Nina; Uyguner, Zehra Oya; Altunoglu, Umut; Nürnberg, Gudrun; Nürnberg, Peter; Rauch, Anita; Li, Yun; Thiel, Christian Thomas; Wollnik, Bernd

    2015-09-01

    Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal proportionate short stature, severe microcephaly, intellectual disability, and characteristic facial features. Here, we describe the novel homozygous splice-site mutations c.383+1G>C and c.4005-9A>G in CDK5RAP2 in two consanguineous families with Seckel syndrome. CDK5RAP2 (CEP215) encodes a centrosomal protein which is known to be essential for centrosomal cohesion and proper spindle formation and has been shown to be causally involved in autosomal recessive primary microcephaly. We establish CDK5RAP2 as a disease-causing gene for Seckel syndrome and show that loss of functional CDK5RAP2 leads to severe defects in mitosis and spindle organization, resulting in cells with abnormal nuclei and centrosomal pattern, which underlines the important role of centrosomal and mitotic proteins in the pathogenesis of the disease. Additionally, we present an intriguing case of possible digenic inheritance in Seckel syndrome: A severely affected child of nonconsanguineous German parents was found to carry heterozygous mutations in CDK5RAP2 and CEP152. This finding points toward a potential additive genetic effect of mutations in CDK5RAP2 and CEP152. PMID:26436113

  5. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex.

    PubMed

    Buchman, Joshua J; Tseng, Huan-Chung; Zhou, Ying; Frank, Christopher L; Xie, Zhigang; Tsai, Li-Huei

    2010-05-13

    Primary autosomal-recessive microcephaly (MCPH) and Majewski osteodysplastic primordial dwarfism type II (MOPDII) are both genetic diseases that result in decreased brain size at birth. MCPH is thought to arise from alterations in the size of the neural progenitor pool, but the cause of this defect has not been thoroughly explored. We find that one of the genes associated with MCPH, Cdk5rap2, is highly expressed in the neural progenitor pool and that its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation. We link Cdk5rap2 function to the pericentriolar material protein pericentrin, loss of function of which is associated with MOPDII. Depletion of pericentrin in neural progenitors phenocopies effects of Cdk5rap2 knockdown and results in decreased recruitment of Cdk5rap2 to the centrosome. Our findings uncover a common mechanism, involving aberrations in the neurogenesis program, that may underlie the development of microcephaly in multiple diseases. PMID:20471352

  6. Generic radiological characterization protocol for surveys conducted for DOE remedial action programs

    SciTech Connect

    Berven, B.A.; Cottrell, W.D.; Leggett, R.W.; Little, C.A.; Myrick, T.E.; Goldsmith, W.A.; Haywood, F.F.

    1986-05-01

    This report describes goals and methodology that can be used by radiological survey contractors in surveys at properties associated with the Department of Energy's remedial action programs. The description includes: (1) a general discussion of the history of the remedial action programs; (2) the types of surveys that may be employed by the Radiological Survey Activities (RASA) contractor; (3) generic survey methods that may be used during radiological surveys; and (4) a format for presenting information and data in a survey report. 9 refs.

  7. Uranium Mill Tailings Remedial Action Project Safety Advancement Field Effort (SAFE) Program

    SciTech Connect

    Not Available

    1994-02-01

    In 1992, the Uranium Mill Tailings Remedial Action (UMTRA) Project experienced several health and safety related incidents at active remediation project sites. As a result, the U.S. Department of Energy (DOE) directed the Technical Assistance Contractor (TAC) to establish a program increasing the DOE`s overall presence at operational remediation sites to identify and minimize risks in operations to the fullest extent possible (Attachments A and B). In response, the TAC, in cooperation with the DOE and the Remedial Action Contractor (RAC), developed the Safety Advancement Field Effort (SAFE) Program.

  8. RAP-011 augments callus formation in closed fractures in rats.

    PubMed

    Morse, Alyson; Cheng, Tegan L; Peacock, Lauren; Mikulec, Kathy; Little, David G; Schindeler, Aaron

    2016-02-01

    ACE-011 is a bone anabolic agent generated by fusing the extracellular domain of the Activin Type 2A receptor (ActRIIA) to an IgG-Fc. The orthopedic utility of ACE-011 was investigated using a murine analogue, RAP-011. Initially, a rat closed fracture model was tested using bi-weekly (biw) 10 mg/kg RAP-011. RAP-011 significantly increased callus length and callus bone volume (BV, +43% at 6w, p < 0.01). The polar moment of inertia was calculated to be substantively increased (+80%, p < 0.01), however mechanical bending tests showed a more modest increase in maximum load to failure (+24%, p < 0.05). Histology indicated enhanced appositional bone growth, but it was hypothesized that reduced remodeling, evidenced by decreased serum CTX (-16% at 6w, p < 0.01), could be compromising bone quality in the callus. A second closed fracture study was performed to examine lower "pulse" [RAP-011(p)] and "sustained" [RAP-011(s)] regimens of biw 0.6mg/kg × 2, 0.35mg/kg × 3 and 0.18mg/kg × 2, 0.1mg/kg × 7 respectively, compared with PTH(1-34) (25 μg/kg/d) and vehicle controls. RAP-011 treatments gave modest increases in callus length and callus BV at 6w (p < 0.01), but did not achieve an increase in maximum load over vehicle. In summary, RAP-011 is effective in promoting bone formation during repair, but optimizing callus bone quality will require further investigation.

  9. 25 CFR 256.28 - What can I do if I disagree with actions taken under the Housing Improvement Program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Housing Improvement Program? 256.28 Section 256.28 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.28 What can I do if I disagree with actions taken under the Housing Improvement Program? You may appeal action or inaction by an official of the Bureau...

  10. 25 CFR 256.28 - What can I do if I disagree with actions taken under the Housing Improvement Program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Housing Improvement Program? 256.28 Section 256.28 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HOUSING HOUSING IMPROVEMENT PROGRAM § 256.28 What can I do if I disagree with actions taken under the Housing Improvement Program? You may appeal action or inaction by an official of the Bureau...

  11. Rho family and Rap GTPase activation assays.

    PubMed

    Jennings, Richard T; Knaus, Ulla G

    2014-01-01

    The detection of Ras superfamily GTPase activity in innate immune cells is important when studying signaling events elicited by various ligands and cellular processes. The development of high-affinity probes detecting the activated, GTP-bound form of small GTPases has significantly enhanced our understanding of initiation and termination of GTPase-regulated signaling pathways. These probes are created by fusing a high-affinity GTPase-binding domain derived from a specific downstream effector protein to glutathione S-transferase (GST). Such domains bind preferentially to the GTP-bound form of the upstream Rho or Ras GTPase. Coupling these probes to beads enables extraction of the complex and subsequent quantification of the active GTP-binding protein by immunoblotting. Although effector domains that discriminate efficiently between GDP- and GTP-bound states and highly specific antibodies are not yet available for every small GTPase, analysis of certain members of the Rho and Ras GTPase family is now routinely performed. Here, we describe affinity-based pulldown assays for detection of Rho GTPase (Rac1/2, Cdc42, RhoA/B) and Rap1/2 activity in stimulated neutrophils or macrophages.

  12. Remote Area Power Supply (RAPS) load and resource profiles.

    SciTech Connect

    Giles, Lauren; Skolnik, Edward G.; Marchionini, Brian; Fall, Ndeye K.

    2007-07-01

    In 1997, an international team interested in the development of Remote Area Power Supply (RAPS) systems for rural electrification projects around the world was organized by the International Lead Zinc Research Organization (ILZRO) with the support of Sandia National Laboratories (SNL). The team focused on defining load and resource profiles for RAPS systems. They identified single family homes, small communities, and villages as candidates for RAPS applications, and defined several different size/power requirements for each. Based on renewable energy and resource data, the team devised a ''strawman'' series of load profiles. A RAPS system typically consists of a renewable and/or conventional generator, power conversion equipment, and a battery. The purpose of this report is to present data and information on insolation levels and load requirements for ''typical'' homes, small communities, and larger villages around the world in order to facilitate the development of robust design practices for RAPS systems, and especially for the storage battery component. These systems could have significant impact on areas of the world that would otherwise not be served by conventional electrical grids.

  13. Action Research as an Approach to Integrating Sustainability into MBA Programs: An Exploratory Study

    ERIC Educational Resources Information Center

    Benn, Suzanne; Dunphy, Dexter

    2009-01-01

    This article reports on an exploratory project that employed an action research approach to integrating sustainability into core subjects in the MBA program at an Australian university. It documents the change methodology used, the theoretical basis for this choice, and the project outcomes. It then identifies some key enabling factors and…

  14. A Structuration Theory Analysis of the Refugee Action Support Program in Greater Western Sydney

    ERIC Educational Resources Information Center

    Naidoo, Loshini

    2009-01-01

    This article uses Gidden's structuration theory to analyse the Refugee Action Support program in Greater Western Sydney. The study shows that many refugee students in Australian high schools experience difficulty with academic transition in mainstream classrooms due to their previous experiences in war-torn countries. As a result of the trauma…

  15. The DiabetAction Program: Implementation in Community-Based Settings

    ERIC Educational Resources Information Center

    Mathieu, Marie-Eve; Brochu, Martin; Beliveau, Louise

    2009-01-01

    Developed for specialists who want to increase the physical activity (PA) level of type 2 diabetic and at-risk individuals, the 10-week DiabetAction program introduced participants to a wide variety of cardiovascular, resistance, balance, and flexibility exercises. Thirty-three of 48 individuals completed the intervention in community-based…

  16. 29 CFR 1608.7 - Affirmative action plans or programs under State or local law.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS... Commission will, in accordance with the “substantial weight” provisions of section 706 of the Act, find no... or programs executed by agreement with State or local government agencies, or by order of State...

  17. 29 CFR 1608.7 - Affirmative action plans or programs under State or local law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS... Commission will, in accordance with the “substantial weight” provisions of section 706 of the Act, find no... or programs executed by agreement with State or local government agencies, or by order of State...

  18. 29 CFR 1608.7 - Affirmative action plans or programs under State or local law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS... Commission will, in accordance with the “substantial weight” provisions of section 706 of the Act, find no... or programs executed by agreement with State or local government agencies, or by order of State...

  19. 29 CFR 1608.7 - Affirmative action plans or programs under State or local law.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS... Commission will, in accordance with the “substantial weight” provisions of section 706 of the Act, find no... or programs executed by agreement with State or local government agencies, or by order of State...

  20. 29 CFR 1608.7 - Affirmative action plans or programs under State or local law.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS... Commission will, in accordance with the “substantial weight” provisions of section 706 of the Act, find no... or programs executed by agreement with State or local government agencies, or by order of State...

  1. The Transformative Power of Youth Action Coalition's Multimodal Arts-for-Change Programming

    ERIC Educational Resources Information Center

    Turner, K. C. Nat; Way, Kate; Gray, Robin R. R.

    2013-01-01

    This article analyzes the potential of a series of Youth Action Coalition's (YAC) Arts-for-Change (AfC) youth programs for literacy and identity development, as well as for engaging youth in addressing issues of social justice. Drawing primarily on transcripts of interviews, surveys, and participant-observation fieldnotes inventorying changes in…

  2. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... number of quantitative analyses designed to evaluate the composition of the workforce of the contractor... perspective, as a powerful management tool, there is a positive correlation between the presence of... affirmative action program must include the following quantitative analyses: (i) Organizational profile—§...

  3. 41 CFR 60-250.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CONTRACTORS AND SUBCONTRACTORS REGARDING SPECIAL DISABLED VETERANS, VETERANS OF THE VIETNAM ERA, RECENTLY SEPARATED VETERANS, AND OTHER PROTECTED VETERANS Affirmative Action Program § 60-250.40 Applicability of the... paragraph (a) of this section shall, within 120 days of the commencement of a contract, prepare and...

  4. 41 CFR 60-300.40 - Applicability of the affirmative action program requirement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CONTRACTORS AND SUBCONTRACTORS REGARDING DISABLED VETERANS, RECENTLY SEPARATED VETERANS, OTHER PROTECTED VETERANS, AND ARMED FORCES SERVICE MEDAL VETERANS Affirmative Action Program § 60-300.40 Applicability of... described in paragraph (a) of this section shall, within 120 days of the commencement of a contract,...

  5. Affirmative Action Strategies and Professional Schools: Case Illustrations of Exemplary Programs.

    ERIC Educational Resources Information Center

    Twale, Darla J.; And Others

    1992-01-01

    A study of seven diverse professional schools suggests that, although a variety of strategies (e.g., early identification, preprofessional contact, resocialization of faculty and matriculated students, and support services) can produce successful affirmative action for women and minority students, a concise, directed program geared to the school's…

  6. 49 CFR 26.107 - What enforcement actions apply to firms participating in the DBE program?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... take enforcement action under 49 CFR Part 31, Program Fraud and Civil Remedies, against any participant... under 49 CFR part 29. (b) If you are a firm that, in order to meet DBE contract goals or other DBE... initiate suspension or debarment proceedings against you under 49 CFR part 29. (c) In a suspension...

  7. 49 CFR 26.107 - What enforcement actions apply to firms participating in the DBE program?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) The Department may take enforcement action under 49 CFR Part 31, Program Fraud and Civil Remedies... under 2 CFR parts 180 and 1200. (b) If you are a firm that, in order to meet DBE contract goals or other... Department may initiate suspension or debarment proceedings against you under 2 CFR parts 180 and 1200....

  8. 49 CFR 26.107 - What enforcement actions apply to firms participating in the DBE program?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) The Department may take enforcement action under 49 CFR Part 31, Program Fraud and Civil Remedies... under 2 CFR parts 180 and 1200. (b) If you are a firm that, in order to meet DBE contract goals or other... Department may initiate suspension or debarment proceedings against you under 2 CFR parts 180 and 1200....

  9. 49 CFR 26.107 - What enforcement actions apply to firms participating in the DBE program?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) The Department may take enforcement action under 49 CFR Part 31, Program Fraud and Civil Remedies... under 2 CFR parts 180 and 1200. (b) If you are a firm that, in order to meet DBE contract goals or other... Department may initiate suspension or debarment proceedings against you under 2 CFR parts 180 and 1200....

  10. Place-Based Learning: Action Learning in MA Program for Educational Practitioners

    ERIC Educational Resources Information Center

    Glassner, Amnon; Eran-Zoran, Yael

    2016-01-01

    The study presents a new pedagogical idea and practice for educational practitioners. The practice was developed as a workshop of MA program in order to change and expand the meaning of education for the wellbeing of the community. The "place-based learning" workshop combined action learning (AL) with project-based learning (PBL). The…

  11. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    .../archive/NotesDocs/25-25%2815%29_FR.pdf ). (A) Reinforced concrete slab bridges (i) Reinforced concrete... Concrete and Steel Bridges AGENCY: Advisory Council on Historic Preservation. ACTION: Program Comment issued for streamlining Section 106 review for undertakings affecting post-1945 concrete and...

  12. Using Participatory Action Research To Evaluate Programs Serving People with Severe Disabilities: Reflections from the Field.

    ERIC Educational Resources Information Center

    Stevens, Karen A.; Folchman, Ruth

    1998-01-01

    This article discusses challenges in using participatory action research (PAR) in the evaluation of programs that provide services and supports to people with severe disabilities. Challenges include the need for modification of the model, time constraints, issues around power and position, and inclusion of individuals with severe disabilities.…

  13. Promoting the Development of Moral Identity, Behavior, and Commitment in a Social Action Program

    ERIC Educational Resources Information Center

    Jones, Jeffrey N.; Warnaar, Bethany L.; Bench, Joshua H.; Stroup, John

    2014-01-01

    Involvement in social action and community service can promote the construction of prosocial identities and enduring patterns of civic behavior. This article explores this important process for youth that participate in the PeaceJam Ambassadors program. High school-aged "PeaceJammers" study the lives of Nobel Peace laureates while…

  14. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    SciTech Connect

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  15. Ohio`s Voluntary Action Program: An economic development tool or a subtle environmental loophole?

    SciTech Connect

    Akinmoladun, T.M.; Lewis, R.A.

    1998-05-01

    In an effort to remediate and reuse abandoned or contaminated industrial properties, the Ohio State legislature passed a law in 1994 that created the Ohio Voluntary Action Program (VAP). VAP consists of a series of incentives for property owners and prospective buyers to accelerate cleanup and reuse of abandoned sites or brownfields. This paper examines the essence of this unconventional approach to socio-economic development and environmental restoration. The weaknesses of the program are discussed, and recommendations are made to make the program more workable, more realistic, and conducive to environmental protection and public health.

  16. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM).

    PubMed

    Ohtsuka, T; Hata, Y; Ide, N; Yasuda, T; Inoue, E; Inoue, T; Mizoguchi, A; Takai, Y

    1999-11-01

    Synaptic scaffolding molecule (S-SCAM) has six PDZ domains through which it interacts with N-methyl-d-aspartate receptors and neuroligin at synaptic junctions. We isolated here a novel S-SCAM-binding protein. This protein has one PDZ, one Ras association, one Ras GDP/GTP exchange protein (Ras GEP) domain, and one C-terminal consensus motif for binding to PDZ domains. We named it nRap GEP (neural Rap GEP). nRap GEP moreover has an incomplete cyclic AMP (cAMP)-binding (CAB) domain. The domain organization of nRap GEP is similar to that of Epac/cAMP-guanine nucleotide exchange factor (GEF) I, except that Epac/cAMP-GEFI has complete CAB and Ras GEP domains but lacks the other two domains and the C-terminal motif. nRap GEP showed GEP activity for Rap1 but did not bind cAMP. nRap GEP was specifically expressed in rat brain. Immunohistochemical analysis revealed that nRap GEP and S-SCAM were localized at synaptic areas of the cerebellum. These results suggest that nRap GEP is a novel neural Rap1-specific GEP which is associated with S-SCAM.

  17. The Data-to-Action Framework: A Rapid Program Improvement Process.

    PubMed

    Zakocs, Ronda; Hill, Jessica A; Brown, Pamela; Wheaton, Jocelyn; Freire, Kimberley E

    2015-08-01

    Although health education programs may benefit from quality improvement methods, scant resources exist to help practitioners apply these methods for program improvement. The purpose of this article is to describe the Data-to-Action framework, a process that guides practitioners through rapid-feedback cycles in order to generate actionable data to improve implementation of ongoing programs. The framework was designed while implementing DELTA PREP, a 3-year project aimed at building the primary prevention capacities of statewide domestic violence coalitions. The authors describe the framework's main steps and provide a case example of a rapid-feedback cycle and several examples of rapid-feedback memos produced during the project period. The authors also discuss implications for health education evaluation and practice.

  18. The Data-to-Action Framework: A Rapid Program Improvement Process.

    PubMed

    Zakocs, Ronda; Hill, Jessica A; Brown, Pamela; Wheaton, Jocelyn; Freire, Kimberley E

    2015-08-01

    Although health education programs may benefit from quality improvement methods, scant resources exist to help practitioners apply these methods for program improvement. The purpose of this article is to describe the Data-to-Action framework, a process that guides practitioners through rapid-feedback cycles in order to generate actionable data to improve implementation of ongoing programs. The framework was designed while implementing DELTA PREP, a 3-year project aimed at building the primary prevention capacities of statewide domestic violence coalitions. The authors describe the framework's main steps and provide a case example of a rapid-feedback cycle and several examples of rapid-feedback memos produced during the project period. The authors also discuss implications for health education evaluation and practice. PMID:26245935

  19. Source localization using recursively applied and projected (RAP) MUSIC

    SciTech Connect

    Mosher, J.C.; Leahy, R.M.

    1998-03-01

    A new method for source localization is described that is based on a modification of the well known multiple signal classification (MUSIC) algorithm. In classical MUSIC, the array manifold vector is projected onto an estimate of the signal subspace, but errors in the estimate can make location of multiple sources difficult. Recursively applied and projected (RAP) MUSIC uses each successively located source to form an intermediate array gain matrix, and projects both the array manifold and the signal subspace estimate into its orthogonal complement. The MUSIC projection is then performed in this reduced subspace. Using the metric of principal angles, the authors describe a general form of the RAP-MUSIC algorithm for the case of diversely polarized sources. Through a uniform linear array simulation, the authors demonstrate the improved Monte Carlo performance of RAP-MUSIC relative to MUSIC and two other sequential subspace methods, S and IES-MUSIC.

  20. Novel Alternative Splice Variants of Mouse Cdk5rap2

    PubMed Central

    Kraemer, Nadine; Issa-Jahns, Lina; Neubert, Gerda; Ravindran, Ethiraj; Mani, Shyamala; Ninnemann, Olaf; Kaindl, Angela M.

    2015-01-01

    Autosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disorder characterized by a pronounced reduction of brain volume and intellectual disability. A current model for the microcephaly phenotype invokes a stem cell proliferation and differentiation defect, which has moved the disease into the spotlight of stem cell biology and neurodevelopmental science. Homozygous mutations of the Cyclin-dependent kinase-5 regulatory subunit-associated protein 2 gene CDK5RAP2 are one genetic cause of MCPH. To further characterize the pathomechanism underlying MCPH, we generated a conditional Cdk5rap2 LoxP/hCMV Cre mutant mouse. Further analysis, initiated on account of a lack of a microcephaly phenotype in these mutant mice, revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice. PMID:26322982

  1. Novel Alternative Splice Variants of Mouse Cdk5rap2.

    PubMed

    Kraemer, Nadine; Issa-Jahns, Lina; Neubert, Gerda; Ravindran, Ethiraj; Mani, Shyamala; Ninnemann, Olaf; Kaindl, Angela M

    2015-01-01

    Autosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disorder characterized by a pronounced reduction of brain volume and intellectual disability. A current model for the microcephaly phenotype invokes a stem cell proliferation and differentiation defect, which has moved the disease into the spotlight of stem cell biology and neurodevelopmental science. Homozygous mutations of the Cyclin-dependent kinase-5 regulatory subunit-associated protein 2 gene CDK5RAP2 are one genetic cause of MCPH. To further characterize the pathomechanism underlying MCPH, we generated a conditional Cdk5rap2 LoxP/hCMV Cre mutant mouse. Further analysis, initiated on account of a lack of a microcephaly phenotype in these mutant mice, revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice. PMID:26322982

  2. Rap and Race: It's Got a Nice Beat, but What about the Message?

    ERIC Educational Resources Information Center

    Sullivan, Rachel E.

    2003-01-01

    Examined racial differences in black and white adolescents' preferences for and interpretations of rap music. Surveys of midwestern U.S. adolescents highlighted limited racial differences in the popularity of rap music. African American youth were more committed to rap and more likely to see it as life affirming. Though both groups had favorable…

  3. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  4. Representing the Programming Process: Goal Structures and Action Sequences in LOGO Programming.

    ERIC Educational Resources Information Center

    McAllister, Alan

    This study developed representations of the LOGO programming process which provide the basis for strategy analyses and a new perspective on problem solving in complex, semantically rich task environments such as LOGO. Nine students, ages 10 to 14, who had been identified as gifted and had previous programming experience, were trained in the…

  5. New Jersey state information handbook: Formerly Utilized Sites Remedial Action Program

    SciTech Connect

    1980-10-31

    Under the implied authority of the Atomic Energy Act of 1954, as amended, radiological surveys and research work has been conducted to determine radiological conditions at former MED/AEC sites. As of this time, 31 sites in 13 states have been identified that require or may require remedial action. This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of New Jersey. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations. The loose-leaf format used in these volumes will allow the material to be updated periodically as the Remedial Action Program progresses.

  6. RNA antisense purification (RAP) for mapping RNA interactions with chromatin.

    PubMed

    Engreitz, Jesse; Lander, Eric S; Guttman, Mitchell

    2015-01-01

    RNA-centric biochemical purification is a general approach for studying the functions and mechanisms of noncoding RNAs. Here, we describe the experimental procedures for RNA antisense purification (RAP), a method for selective purification of endogenous RNA complexes from cell extracts that enables mapping of RNA interactions with chromatin. In RAP, the user cross-links cells to fix endogenous RNA complexes and purifies these complexes through hybrid capture with biotinylated antisense oligos. DNA loci that interact with the target RNA are identified using high-throughput DNA sequencing.

  7. New Mexico state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    2014-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  8. New York state information handbook formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying our the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New York. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  9. New Mexico state information handbook formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Informaion Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  10. Modularity and hierarchical organization of action programs in human acquisition of graphic skills.

    PubMed

    Manoel, Edison de J; Basso, Luciano; Correa, Umberto C; Tani, Go

    2002-12-25

    If motor or action programs become modules with practice their defining features (e.g. relative timing) should remain relatively invariant in new tasks. To test this hypothesis 24 adults practiced a graphic skill over 100 trials and were transferred to a more complex task enclosing the practiced figure. The data acquired by a digital tablet resulted in total movement and total pause times to draw the figure indicating skill acquisition and variability measures of relative timing and pause time and sequencing referring to features that identify a module. Being transferred to a more complex task did not lead to significant increases in the time to perform the criterion figure embedded in the new pattern. Modularity was evidenced by the stability of relative timing and sequencing shown in the performance of the criterion figure. Hence, it might be that action programs become modules that are then hierarchically organized to form more complex skills.

  11. A Health Newsletter To Teach Science Knowledge: BioRAP!

    ERIC Educational Resources Information Center

    Froman, Robin D.; Owen, Steven V.; Del Rio-Parent, Lourdes

    This research describes the evaluation of a science curriculum newsletter called BioRAP which serves as a vehicle to teach current health science content. The research objectives were to estimate the relationships of socioeconomic status, ethnic group, gender, grade, student ability, and classroom use characteristics with student knowledge and…

  12. Multilingual Codeswitching in Quebec Rap: Poetry, Pragmatics and Performativity

    ERIC Educational Resources Information Center

    Sarkar, Mela; Winer, Lise

    2006-01-01

    Quebec rap lyrics stand out on the world Hip-Hop scene by virtue of the ease and rapidity with which performers in this multilingual, multiethnic youth community codeswitch, frequently among three or more languages or language varieties (usually over a French and/or English base) in the same song. We construct a framework for understanding…

  13. Rap Therapy? An Innovative Approach to Groupwork with Urban Adolescents.

    ERIC Educational Resources Information Center

    DeCarlo, Alonzo

    2001-01-01

    Describes a study in which young, urban African American adolescents with behavior problems participated in weekly group sessions that used rap music to promote the development of appropriate social skills related to morality, identity, judgement, decision making, anger management, impulse control, and crime and punishment. Overall, student…

  14. Integrating RAP in Public Schools: Successes and Challenges

    ERIC Educational Resources Information Center

    Shields, Julie; Milstein, Mindy; Posner, Sandi Ives

    2010-01-01

    For students with emotional disability (ED), school can be a stressful experience marked by disapproval, rejection, isolation, and shame. Staff serving these students in a large school district received Response Ability Pathways (RAP) training. This article summarizes positive impacts on behavior, as well as ongoing challenges in changing school…

  15. Escaping Embarrassment: Face-Work in the Rap Cipher

    ERIC Educational Resources Information Center

    Lee, Jooyoung

    2009-01-01

    How do individuals escape embarrassing moments in interaction? Drawing from ethnographic fieldwork, in-depth interviews, and video recordings of weekly street corner ciphers (impromptu rap sessions), this paper expands Goffman's theory of defensive and protective face-work. The findings reveal formulaic and indirect dimensions of face-work. First,…

  16. Creating the Infrastructure for Organizational Change with RAP

    ERIC Educational Resources Information Center

    Shields, Julie; Milstein, Mindy; Robinson, Consuela

    2012-01-01

    In order to thrive, organizations must undergo significant change at various points in their development. Such is the case with Montgomery County Public Schools (MCPS) Emotional Disability Services in the beginning process of implementing Response Ability Pathways (RAP) with staff and students. The impetus for change originated from an…

  17. Hybrid Texts: Fifth Graders, Rap Music, and Writing

    ERIC Educational Resources Information Center

    Christianakis, Mary

    2011-01-01

    Consistent with a sociocritical frame and the analytic tools of hybridity theory, this article explicates how urban fifth-grade children made language hybrids using rap and poetry to participate in classroom literacy. Ethnographic data from a yearlong study illustrate two key findings. First, standards-based and canon-driven writing models…

  18. Rap Music by Black Male Artists: A Psychotheological Interpretation.

    ERIC Educational Resources Information Center

    Pressley, Arthur

    1992-01-01

    Provides a psychotheological interpretation of rap music by African-American male artists and of its audience, examining the music and its social context. Common themes include despair over acute psychosocial and physical needs, intensity and violence as a means of personal integration, ontological insecurity, and desire for transformation and…

  19. Fresh Out of School: Rap Music's Discursive Battle with Education

    ERIC Educational Resources Information Center

    Au, Wayne

    2005-01-01

    The rap music lyrics were analyzed to flush out the hip-hop culture's perspective on the education of African American (AA) youth. It was found that there is a need for the implementation of more culturally relevant curricula in schools, which benefits the students to understand hip-hop culture.

  20. Programming or inhibiting action: evidence for differential autonomic nervous system response patterns.

    PubMed

    Collet, C; Dittmar, A; Vernet-Maury, E

    1999-06-01

    In the general context of decision-making analysis, the aim of this study was to investigate autonomic nervous system activity when movement execution is inhibited just before onset. Using a 'Go/NoGo' paradigm, 16 subjects (nine males and seven females) had to intercept green table-tennis balls thrown by a robot, with the inner side of their hand and by arm extension. Conversely, they had to inhibit movement programming when a red ball was thrown. Results were displayed in terms of success or failure in view of the aim of each trial. Electrodermal, thermo-vascular and cardio-respiratory parameters were continuously recorded from the non-dominant hand. Results showed that the duration of autonomic responses was significantly longer in action than in inhibition. Temperature responses were negative but significantly more marked in action. Instantaneous respiratory frequency amplitude responses were positive in both action and inhibition conditions, but higher in action. Instantaneous heart rate responses confirmed that inhibition elicits cardiac deceleration. Autonomic responses were shown capable of distinguishing action from inhibition, thus reflecting central nervous system functioning. Results are discussed in terms of autonomic response specificity. PMID:10437637

  1. Learning Spatio-Temporal Representations for Action Recognition: A Genetic Programming Approach.

    PubMed

    Liu, Li; Shao, Ling; Li, Xuelong; Lu, Ke

    2016-01-01

    Extracting discriminative and robust features from video sequences is the first and most critical step in human action recognition. In this paper, instead of using handcrafted features, we automatically learn spatio-temporal motion features for action recognition. This is achieved via an evolutionary method, i.e., genetic programming (GP), which evolves the motion feature descriptor on a population of primitive 3D operators (e.g., 3D-Gabor and wavelet). In this way, the scale and shift invariant features can be effectively extracted from both color and optical flow sequences. We intend to learn data adaptive descriptors for different datasets with multiple layers, which makes fully use of the knowledge to mimic the physical structure of the human visual cortex for action recognition and simultaneously reduce the GP searching space to effectively accelerate the convergence of optimal solutions. In our evolutionary architecture, the average cross-validation classification error, which is calculated by an support-vector-machine classifier on the training set, is adopted as the evaluation criterion for the GP fitness function. After the entire evolution procedure finishes, the best-so-far solution selected by GP is regarded as the (near-)optimal action descriptor obtained. The GP-evolving feature extraction method is evaluated on four popular action datasets, namely KTH, HMDB51, UCF YouTube, and Hollywood2. Experimental results show that our method significantly outperforms other types of features, either hand-designed or machine-learned.

  2. Probabilistic Planning with Imperfect Sensing Actions Using Hybrid Probabilistic Logic Programs

    NASA Astrophysics Data System (ADS)

    Saad, Emad

    Effective planning in uncertain environment is important to agents and multi-agents systems. In this paper, we introduce a new logic based approach to probabilistic contingent planning (probabilistic planning with imperfect sensing actions), by relating probabilistic contingent planning to normal hybrid probabilistic logic programs with probabilistic answer set semantics [24]. We show that any probabilistic contingent planning problem can be encoded as a normal hybrid probabilistic logic program. We formally prove the correctness of our approach. Moreover, we show that the complexity of finding a probabilistic contingent plan in our approach is NP-complete. In addition, we show that any probabilistic contingent planning problem, \\cal PP, can be encoded as a classical normal logic program with answer set semantics, whose answer sets corresponds to valid trajectories in \\cal PP. We show that probabilistic contingent planning problems can be encoded as SAT problems. We present a new high level probabilistic action description language that allows the representation of sensing actions with probabilistic outcomes.

  3. Data base management for the Remedial Action Program at Oak Ridge National Laboratory

    SciTech Connect

    Voorhees, L.D.; Cushman, R.M.; Faulkner, M.A.; Horwedel, B.M.

    1986-08-01

    The Oak Ridge National Laboratory's (ORNL's) Remedial Action Program was established to provide appropriate corrective measures at over 140 sites that were contaminated with radioactive and/or hazardous chemical wastes. To achieve this goal, numerous and varied studies are being conducted which will result in the collection of an unprecedented amount of data for the ORNL site. To manage such data effectively and efficiently, a computerized data base is being developed. The data base provides a unified repository for all data generated within the Remedial Action Program, to allow for necessary storage, manipulation, analyses, assessment, display, and report generation. Data base management for the Remedial Action Program is documented in this report by: (1) defining the organization of the data management staff and the services provided; (2) describing the design of the data base, including its management system, organization, and applications; (3) providing examples of the current and anticipated tasks; and (4) discussing quality assurance measures implemented to control the accuracy of the data entries and the security of the data.

  4. Installation and operation of a large scale RAPS system in Peru

    NASA Astrophysics Data System (ADS)

    Cole, J. F.

    In 1997, International Lead Zinc Research Organization Inc. (ILZRO), Solar Energy Industries Association (SEIA), and the Ministry of Energy and Mines (MEM) of Peru signed a Memorandum of Understanding to facilitate the installation of hybrid remote area power supply (RAPS) systems in the Amazon region of Peru. Many remote villages in this vast region have either no or limited electricity supplied by diesel generators running a few hours per day. Subsequently, ILZRO sponsored the engineering design of the hybrid RAPS system and SEIA supported a socio-economic study to determine the sustainability of such systems and the locations for pilot installations. In mid-1998, the Peruvian government approved the design of the system. ILZRO then began efforts to obtain governmental and inter-governmental funding to supplement its own funds to underwrite the cost of manufacture and installation of the systems in two villages in the Amazon region. Additional major funding has been received from the Global Environmental Facility (GEF) administered by the United Nations Development Program (UNDP) and from the Common Fund for Commodities (CFC). Funds have also been received from the US Department of Energy, the International Greenhouse Partnership (Australia) and the Peruvian government. The RAPS system consists of modules designed to provide 150 kW h per day of utility grade ac electricity over a 24 h period. Each module contains a diesel generator, battery bank using heavy-duty 2 V VRLA GEL batteries, a battery charger, a photovoltaic array and an ac/dc inverter. The batteries and electrical components are housed in modified shipping containers. The modules can be installed with a new generator or retrofitted to an existing generator. The charging and discharging regime of the batteries has been recommended by a study carried out by CSIRO, which has simulated the RAPS operation. The system will employ a partial-state-of-charge (PSOC) regime in order to optimize the life of the

  5. Assurance Program for Remedial Action (APRA) microcomputer-operated bibliography management system

    SciTech Connect

    Stenner, R.D.; Washburn, D.K.; Denham, D.H.

    1985-06-01

    Pacific Northwest Laboratory (PNL) provided technical assistance to the Office of Operational Safety (OOS) in developing their Assurance Program for Remedial Action (APRA). The APRA Bibliography Management System (BMS), a microcomputer-operated system designed to file, locate and retrieve project-specific bibliographic data, was developed to manage the documentation associated with APRA. The BMS uses APRABASE, a PNL-developed computer program written in dBASE II language, which is designed to operate using the commercially available dBASE II database software. This document describes the APRABASE computer program, its associated subprograms, and the dBASE II APRA file. A User's Manual is also provided in the document. Although the BMS was designed to manage APRA-associated documents, it could be easily adapted for use in handling bibliographic data associated with any project.

  6. Assessment of the NASA Space Shuttle Program's Problem Reporting and Corrective Action System

    NASA Technical Reports Server (NTRS)

    Korsmeryer, D. J.; Schreiner, J. A.; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper documents the general findings and recommendations of the Design for Safety Programs Study of the Space Shuttle Programs (SSP) Problem Reporting and Corrective Action (PRACA) System. The goals of this Study were: to evaluate and quantify the technical aspects of the SSP's PRACA systems, and to recommend enhancements addressing specific deficiencies in preparation for future system upgrades. The Study determined that the extant SSP PRACA systems accomplished a project level support capability through the use of a large pool of domain experts and a variety of distributed formal and informal database systems. This operational model is vulnerable to staff turnover and loss of the vast corporate knowledge that is not currently being captured by the PRACA system. A need for a Program-level PRACA system providing improved insight, unification, knowledge capture, and collaborative tools was defined in this study.

  7. Annual status report on the Uranium Mill Tailings Remedial Action Program

    SciTech Connect

    Not Available

    1989-12-01

    This eleventh annual status report summarizes activities of the Uranium Mill Tailings Remedial Action (UMTRA) Project undertaken during Fiscal Year (FY) 1989 by the US Department of Energy (DOE) and other agencies. Project goals for FY 1990 are also presented. An annual report of this type was a statutory requirement through January 1, 1986, pursuant to the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95--604. The DOE will continue to submit an annual report through project completion in order to inform the public of yearly project status. Title I of the UMTRCA authorizes the DOE, in cooperation with affected states and Indian tribes within whose boundaries designated uranium processing sites are located, to provide a program of assessment and remedial action at such sites. The purpose of the remedial action is to stabilize and control the tailings and other residual radioactive materials located on the inactive uranium processing sites in a safe and environmentally sound manner and to minimize or eliminate potential radiation health hazards. Commercial and residential properties in the vicinity of designated processing sites that are contaminated with material from the sites, herein referred to as vicinity properties,'' are also eligible for remedial action. Included in the UMTRA Project are 24 inactive uranium processing sites and associated vicinity properties located in 10 states, and the vicinity properties associated with Edgemont, South Dakota, an inactive uranium mill currently owned by the Tennessee Valley Authority (TVA).

  8. Radiological protection guidelines for the Formerly Utilized Sites Remedial Action Program and Remote Surplus Facilities Management Program

    SciTech Connect

    Gilbert, T.L.

    1984-01-01

    The need for a definitive basis for radiological guidelines and criteria for FUSRAP became apparent by 1981 and led ORO to sponsor a joint ANL/BNI/LANL/ORO effort under the chairmanship of Wayne Hansen (LANL) that resulted in a final FUSRAP radiological guidelines document in March 1983. A separate effort to develop guidelines for remedial action criteria for SFMP was in progress at PNL. The need to coordinate both efforts with impending revisions of DOE Radiological Protection Standards and impending new developments in EPA and NRC Radiological Protection Standards led to convening of the first DOE Workshop on Remedial Action Criteria in Gaithersburg, Maryland, in February 1984, followed by a second workshop in June 1984 at ANL. The major decisions were to base the criteria on dosimetry models and basic limits currently recommended by the International Commission on Radiological Protection, to emphasize the development and use of site-specific rather than generic guidelines and criteria for residual radionuclide concentrations in the ground, and to prepare a manual to accompany the guidelines that would present procedures and tables for deriving site-specific soil guidelines and criteria for the remedial action programs. A joint ANL/LANL/ORNL/PNL effort to prepare a definitive set of guidelines and a manual has been initiated. The scope, status, and current plans for this effort, and some of the key issues, are presented. 10 references, 1 table.

  9. Cloning and characterization of Rap GTPase from the Chinese white shrimp Fenneropenaeus chinensis.

    PubMed

    Ren, Qian; Zhou, Jing; Jia, Yu-Ping; Wang, Xian-Wei; Zhao, Xiao-Fan; Wang, Jin-Xing

    2012-01-01

    Ras-related protein Rap GTPase has been implicated in cell adhesion, cell proliferation, and cell junction formation. The first shrimp Rap cDNA (FcRap) was recently identified from the Chinese white shrimp Fenneropenaeus chinensis. The full length of FcRap is 1013 bp, with a 561 bp open reading frame that encodes a 186 amino acid protein. FcRap has a calculated molecular mass of 20.90 kDa and pI of 6.37. Phylogenetic analysis shows that FcRap and other Rap proteins are clustered into one group. Results from the quantitative real-time polymerase chain reaction show that FcRap could be detected mainly in the hemocytes, hepatopancreas, stomach, and gills, whereas a relatively lower expression level could be detected in the heart and intestines. FcRap in the hemocytes was upregulated 2h post Vibrio challenge, and it was upregulated 2h post white spot syndrome virus (WSSV) challenge, and peaked at 6h before it declined at 12h. No variation in the FcRap transcript was observed in the gills under the Vibrio challenge, but it was initially downregulated 2h post WSSV challenge, and then it was upregulated and peaked at 6h before it was eventually went down at 12h. The rFcRap protein was successfully expressed in Escherichia coli BL21DE3. The pull-down analysis showed that rFcRap protein could interact with VP28, an envelope protein of WSSV. The probable roles of Rap GTPase in shrimp innate immunity are presented for the first time.

  10. Neural Correlates of Lyrical Improvisation: An fMRI Study of Freestyle Rap

    PubMed Central

    Liu, Siyuan; Chow, Ho Ming; Xu, Yisheng; Erkkinen, Michael G.; Swett, Katherine E.; Eagle, Michael W.; Rizik-Baer, Daniel A.; Braun, Allen R.

    2012-01-01

    The neural correlates of creativity are poorly understood. Freestyle rap provides a unique opportunity to study spontaneous lyrical improvisation, a multidimensional form of creativity at the interface of music and language. Here we use functional magnetic resonance imaging to characterize this process. Task contrast analyses indicate that improvised performance is characterized by dissociated activity in medial and dorsolateral prefrontal cortices, providing a context in which stimulus-independent behaviors may unfold in the absence of conscious monitoring and volitional control. Connectivity analyses reveal widespread improvisation-related correlations between medial prefrontal, cingulate motor, perisylvian cortices and amygdala, suggesting the emergence of a network linking motivation, language, affect and movement. Lyrical improvisation appears to be characterized by altered relationships between regions coupling intention and action, in which conventional executive control may be bypassed and motor control directed by cingulate motor mechanisms. These functional reorganizations may facilitate the initial improvisatory phase of creative behavior. PMID:23155479

  11. The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35.

    PubMed

    Weiss, J; Rubinfeld, B; Polakis, P G; McCormick, F; Cavenee, W K; Arden, K C

    1994-01-01

    Using a panel of somatic cell hybrids we have mapped the locus for Rap1-GTPase activating protein 1 (RAP1GA1) to human chromosome 1. Fluorescence in situ hybridization experiments independently confirmed the chromosomal localization and refined it to 1p36.1-->p35.

  12. “Everybody Gotta Have a Dream”: Rap-centered Aspirations among Young Black Males Involved in Rap Music Production – A Qualitative Study

    PubMed Central

    Foster, B. Brian

    2015-01-01

    Youth express diverse desires for their educational and occupational futures. Sometimes these aspirations are directed towards somewhat unconventional careers such as rapping and other types of involvement in rap music production. Although many studies have examined traditional educational and occupational aspirations, less is known about the factors that give rise to rap-centered aspirations and how individuals pursue them, particularly as they transition to early adulthood. Drawing on 54 semi- and unstructured interviews with 29 black young men involved in rap music production, I find that rap-centered aspirations are shaped by a range of factors, most notably feedback regarding one’s rap skills, access to recording and production equipment, and the financial means to maintain involvement in rap music production while also ensuring personal and family economic stability. The young men in the study attached different meanings to their aspirations and sometimes recast their motivations for participating in rap music production in response to various social and economic factors. PMID:26005703

  13. Environmental compliance assessment findings for Weldon Spring Site Remedial Action Program

    SciTech Connect

    Sigmon, C.F.; Levine, M.B.

    1990-03-02

    This report presents the results of an environmental assessment conducted at Weldon Spring Site Remedial Action Project (WSSRAP) in St. Charles County, Missouri, in accordance with the Formerly Utilized Sites Remedial Action Program (FUSRAP) Environmental Compliance Assessment Checklists. The purpose of this assessment was to evaluate the compliance of the site with applicable federal and Missouri environment regulations. Assessments activities included the following: review of site records, reports ,and files; inspection of the WSSRAP storage building, other selected buildings, and the adjacent grounds; and interviews with project personnel. This assessment was conducted on August 28-30, 1989. The assessment covered five management areas as set forth in the Checklist: Hazardous Waste Management, Polychlorinated Biphenyls (PCBs) Management; Air Emissions; Wastewater Discharges and Petroleum Management. No samples were collected. 1 ref., 2 figs., 1 tab.

  14. Computed tomography screening: the international early lung cancer action program experience.

    PubMed

    Henschke, Claudia I; Boffetta, Paolo; Yankelevitz, David F; Altorki, Nasser

    2015-05-01

    The International Early Lung Cancer Action Program (I-ELCAP) used a novel study design that provided quantitative information about annual CT screening for lung cancer. The results stimulated additional studies of lung cancer screening and ultimately led to the National Lung Screening Trial (NLST) being initiated in 2002, as the initial report in 1999 was sufficiently compelling to reawaken interest in screening for lung cancer. The authors think that the I-ELCAP and NLST "story" provides a strong argument for relevant agencies to consider alternative study designs for the public funding of studies aimed at evaluating the effectiveness of screening and other medical trials.

  15. Reducing cyberbullying: A theory of reasoned action-based video prevention program for college students.

    PubMed

    Doane, Ashley N; Kelley, Michelle L; Pearson, Matthew R

    2016-01-01

    Few studies have evaluated the effectiveness of cyberbullying prevention/intervention programs. The goals of the present study were to develop a Theory of Reasoned Action (TRA)-based video program to increase cyberbullying knowledge (1) and empathy toward cyberbullying victims (2), reduce favorable attitudes toward cyberbullying (3), decrease positive injunctive (4) and descriptive norms about cyberbullying (5), and reduce cyberbullying intentions (6) and cyberbullying behavior (7). One hundred sixty-seven college students were randomly assigned to an online video cyberbullying prevention program or an assessment-only control group. Immediately following the program, attitudes and injunctive norms for all four types of cyberbullying behavior (i.e., unwanted contact, malice, deception, and public humiliation), descriptive norms for malice and public humiliation, empathy toward victims of malice and deception, and cyberbullying knowledge significantly improved in the experimental group. At one-month follow-up, malice and public humiliation behavior, favorable attitudes toward unwanted contact, deception, and public humiliation, and injunctive norms for public humiliation were significantly lower in the experimental than the control group. Cyberbullying knowledge was significantly higher in the experimental than the control group. These findings demonstrate a brief cyberbullying video is capable of improving, at one-month follow-up, cyberbullying knowledge, cyberbullying perpetration behavior, and TRA constructs known to predict cyberbullying perpetration. Considering the low cost and ease with which a video-based prevention/intervention program can be delivered, this type of approach should be considered to reduce cyberbullying.

  16. Reducing cyberbullying: A theory of reasoned action-based video prevention program for college students.

    PubMed

    Doane, Ashley N; Kelley, Michelle L; Pearson, Matthew R

    2016-01-01

    Few studies have evaluated the effectiveness of cyberbullying prevention/intervention programs. The goals of the present study were to develop a Theory of Reasoned Action (TRA)-based video program to increase cyberbullying knowledge (1) and empathy toward cyberbullying victims (2), reduce favorable attitudes toward cyberbullying (3), decrease positive injunctive (4) and descriptive norms about cyberbullying (5), and reduce cyberbullying intentions (6) and cyberbullying behavior (7). One hundred sixty-seven college students were randomly assigned to an online video cyberbullying prevention program or an assessment-only control group. Immediately following the program, attitudes and injunctive norms for all four types of cyberbullying behavior (i.e., unwanted contact, malice, deception, and public humiliation), descriptive norms for malice and public humiliation, empathy toward victims of malice and deception, and cyberbullying knowledge significantly improved in the experimental group. At one-month follow-up, malice and public humiliation behavior, favorable attitudes toward unwanted contact, deception, and public humiliation, and injunctive norms for public humiliation were significantly lower in the experimental than the control group. Cyberbullying knowledge was significantly higher in the experimental than the control group. These findings demonstrate a brief cyberbullying video is capable of improving, at one-month follow-up, cyberbullying knowledge, cyberbullying perpetration behavior, and TRA constructs known to predict cyberbullying perpetration. Considering the low cost and ease with which a video-based prevention/intervention program can be delivered, this type of approach should be considered to reduce cyberbullying. PMID:26349445

  17. 13 CFR 120.1425 - Grounds for enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Grounds for enforcement actions-Intermediaries participating in the Microloan Program and NTAPs. 120.1425 Section 120.1425 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions §...

  18. 13 CFR 120.1425 - Grounds for enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Grounds for enforcement actions-Intermediaries participating in the Microloan Program and NTAPs. 120.1425 Section 120.1425 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions §...

  19. 13 CFR 120.1540 - Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs. 120.1540 Section 120.1540 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions §...

  20. 13 CFR 120.1540 - Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Types of enforcement actions... Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions § 120.1540 Types of enforcement actions—Intermediaries participating in the Microloan Program and NTAPs....

  1. 13 CFR 120.1540 - Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Types of enforcement actions... Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions § 120.1540 Types of enforcement actions—Intermediaries participating in the Microloan Program and NTAPs....

  2. 13 CFR 120.1540 - Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Types of enforcement actions... Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions § 120.1540 Types of enforcement actions—Intermediaries participating in the Microloan Program and NTAPs....

  3. 13 CFR 120.1540 - Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Types of enforcement actions... Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions § 120.1540 Types of enforcement actions—Intermediaries participating in the Microloan Program and NTAPs....

  4. Training School Personnel to Implement a Universal School-Based Prevention of Depression Program under Real-World Conditions

    ERIC Educational Resources Information Center

    Harnett, P.H.; Dadds, M.R.

    2004-01-01

    The present study evaluated the impact of a universal prevention of depression program [the Resourceful Adolescent Program (RAP)] when implemented under real-world conditions in a school setting. Prior research has found the RAP program to be beneficial for high-school students when the program was implemented by university staff selected,…

  5. A Randomized Placebo-Controlled Trial of a School-Based Depression Prevention Program.

    ERIC Educational Resources Information Center

    Merry, Sally; McDowell, Heather; Wild, Chris J.; Bir, Julliet; Cunliffe, Rachel

    2004-01-01

    Objective: To conduct a placebo-controlled study of the effectiveness of a universal school-based depression prevention program. Method: Three hundred ninety-two students age 13 to 15 from two schools were randomized to intervention (RAP-Kiwi) and placebo programs run by teachers. RAP-Kiwi was an 11-session manual-based program derived from…

  6. What's the hype about CDK5RAP2?

    PubMed

    Kraemer, Nadine; Issa, Lina; Hauck, Stefanie C R; Mani, Shyamala; Ninnemann, Olaf; Kaindl, Angela M

    2011-05-01

    Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an isolated developmental defect of the brain, particularly of the cerebral cortex, and was thus historically also referred to as microcephalia vera. Unraveling the pathomechanisms leading to this human disease is fascinating scientists because it can convey insight into basic mechanisms of physiologic brain development (particularly of cortex formation). It also finds itself in the spotlight because of its implication in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might lead to disease in humans when the function of this protein is disturbed. PMID:21327915

  7. cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotinia sclerotiorum.

    PubMed

    Chen, Changbin; Dickman, Martin B

    2005-01-01

    Sclerotinia sclerotiorum is a filamentous ascomycete phytopathogen able to infect an extremely wide range of cultivated plants. Our previous studies have shown that increases in cAMP levels result in the impairment of the development of the sclerotium, a highly differentiated structure important in the disease cycle of this fungus. cAMP also inhibits the activation of a S. sclerotiorum mitogen-activated protein kinase (MAPK), which we have previously shown to be required for sclerotial maturation; thus cAMP-mediated sclerotial inhibition is modulated through MAPK. However, the mechanism(s) by which cAMP inhibits MAPK remains unclear. Here we demonstrate that a protein kinase A (PKA)-independent signalling pathway probably mediates MAPK inhibition by cAMP. Expression of a dominant negative form of Ras, an upstream activator of the MAPK pathway, also inhibited sclerotial development and MAPK activation, suggesting that a conserved Ras/MAPK pathway is required for sclerotial development. Evidence from bacterial toxins that specifically inhibit the activity of small GTPases, suggested that Rap-1 or Ras is involved in cAMP action. The Rap-1 inhibitor, GGTI-298, restored MAPK activation in the presence of cAMP, further suggesting that Rap-1 is responsible for cAMP-dependent MAPK inhibition. Importantly, inhibition of Rap-1 is able to restore sclerotial development blocked by cAMP. Our results suggest a novel mechanism involving the requirement of Ras/MAPK pathway for sclerotial development that is negatively regulated by a PKA-independent cAMP signalling pathway. Cross-talk between these two pathways is mediated by Rap-1. PMID:15612936

  8. Dynamic recruitment of CDK5RAP2 to centrosomes requires its association with dynein.

    PubMed

    Jia, Yue; Fong, Ka-Wing; Choi, Yuk-Kwan; See, Siu-San; Qi, Robert Z

    2013-01-01

    CDK5RAP2 is a centrosomal protein known to be involved in the regulation of the γ-tubulin ring complex and thus the organization of microtubule arrays. However, the mechanism by which CDK5RAP2 is itself recruited to centrosomes is poorly understood. We report here that CDK5RAP2 displays highly dynamic attachment to centrosomes in a microtubule-dependent manner. CDK5RAP2 associates with the retrograde transporter dynein-dynactin and contains a sequence motif that binds to dynein light chain 8. Significantly, disruption of cellular dynein-dynactin function reduces the centrosomal level of CDK5RAP2. These results reveal a key role of the dynein-dynactin complex in the dynamic recruitment of CDK5RAP2 to centrosomes. PMID:23874654

  9. The Expedited Remedial Action Program: A case study. The Alhambra Front Street manufactured gas plant site

    SciTech Connect

    Padleschat, J.A.; McMahon, T.D.

    1996-12-31

    Early in 1995, the Department of Toxic Substances Control asked Southern California Gas Company (SoCalGas) to enter one of its manufactured gas plant (MGP) sites into the new Expedited Remedial Action Program (ERAP). SoCalGas initially was not enthusiastic about the new program. Nevertheless, SoCalGas submitted an application for its Alhambra MGP site to be selected for the ERAP. The Alhambra Site was accepted into ERAP in November 1995, and was the first ERAP site to have orphan shares. MGP sites are well suited to the ERAP. They often involve few potentially responsible parties and can be expected to have the same primary contaminants: polycyclic aromatic hydrocarbons (PAH), which are a byproduct of the gas manufacturing process, and petroleum hydrocarbons from the crude oil feedstock used to manufacture the gas.

  10. Uranium Mill Tailings Remedial Action Project: Cost Reduction and Productivity Improvement Program Project Plan

    SciTech Connect

    Not Available

    1991-11-01

    The purpose of the Cost Reduction/Productivity Improvement Program Plan is to formalize and improve upon existing efforts to control costs which have been underway since project inception. This program plan has been coordinated with the Department of Energy (DOE) Office of Environmental Management (EM) and the DOE Field Office, Albuquerque (AL). It incorporates prior Uranium Mill Tallings Remedial Action (UMTRA) Project Office guidance issued on the subject. The opportunities for reducing cosh and improving productivity are endless. The CR/PIP has these primary objectives: Improve productivity and quality; heighten the general cost consciousness of project participants, at all levels of their organizations; identify and implement specific innovative employee ideas that extend beyond what is required through existing processes and procedures; emphasize efforts that create additional value for the money spent by maintaining the project Total Estimated Cost (TEC) at the lowest possible level.

  11. Uranium Mill Tailings Remedial Action Project: Cost Reduction and Productivity Improvement Program Project Plan. Revised

    SciTech Connect

    Not Available

    1991-11-01

    The purpose of the Cost Reduction/Productivity Improvement Program Plan is to formalize and improve upon existing efforts to control costs which have been underway since project inception. This program plan has been coordinated with the Department of Energy (DOE) Office of Environmental Management (EM) and the DOE Field Office, Albuquerque (AL). It incorporates prior Uranium Mill Tallings Remedial Action (UMTRA) Project Office guidance issued on the subject. The opportunities for reducing cosh and improving productivity are endless. The CR/PIP has these primary objectives: Improve productivity and quality; heighten the general cost consciousness of project participants, at all levels of their organizations; identify and implement specific innovative employee ideas that extend beyond what is required through existing processes and procedures; emphasize efforts that create additional value for the money spent by maintaining the project Total Estimated Cost (TEC) at the lowest possible level.

  12. Development of a wheelchair skills home program for older adults using a participatory action design approach.

    PubMed

    Giesbrecht, Edward M; Miller, William C; Mitchell, Ian M; Woodgate, Roberta L

    2014-01-01

    Restricted mobility is the most common impairment among older adults and a manual wheelchair is often prescribed to address these limitations. However, limited access to rehabilitation services results in older adults typically receiving little or no mobility training when they receive a wheelchair. As an alternative and novel approach, we developed a therapist-monitored wheelchair skills home training program delivered via a computer tablet. To optimize efficacy and adherence, principles of self-efficacy and adult learning theory were foundational in the program design. A participatory action design approach was used to engage older adult wheelchair users, care providers, and prescribing clinicians in an iterative design and development process. A series of prototypes were fabricated and revised, based on feedback from eight stakeholder focus groups, until a final version was ready for evaluation in a clinical trial. Stakeholder contributions affirmed and enhanced the foundational theoretical principles and provided validation of the final product for the target population. PMID:25276768

  13. Lessons Learned for Cx PRACA. Constellation Program Problem Reporting, Analysis and Corrective Action Process and System

    NASA Technical Reports Server (NTRS)

    Kelle, Pido I.; Ratterman, Christian; Gibbs, Cecil

    2009-01-01

    This slide presentation reviews the Constellation Program Problem Reporting, Analysis and Corrective Action Process and System (Cx PRACA). The goal of the Cx PRACA is to incorporate Lessons learned from the Shuttle, ISS, and Orbiter programs by creating a single tool for managing the PRACA process, that clearly defines the scope of PRACA applicability and what must be reported, and defines the ownership and responsibility for managing the PRACA process including disposition approval authority. CxP PRACA is a process, supported by a single information gathering data module which will be integrated with a single CxP Information System, providing interoperability, import and export capability making the CxP PRACA a more effective and user friendly technical and management tool.

  14. Development of a Wheelchair Skills Home Program for Older Adults Using a Participatory Action Design Approach

    PubMed Central

    Giesbrecht, Edward M.; Miller, William C.; Mitchell, Ian M.; Woodgate, Roberta L.

    2014-01-01

    Restricted mobility is the most common impairment among older adults and a manual wheelchair is often prescribed to address these limitations. However, limited access to rehabilitation services results in older adults typically receiving little or no mobility training when they receive a wheelchair. As an alternative and novel approach, we developed a therapist-monitored wheelchair skills home training program delivered via a computer tablet. To optimize efficacy and adherence, principles of self-efficacy and adult learning theory were foundational in the program design. A participatory action design approach was used to engage older adult wheelchair users, care providers, and prescribing clinicians in an iterative design and development process. A series of prototypes were fabricated and revised, based on feedback from eight stakeholder focus groups, until a final version was ready for evaluation in a clinical trial. Stakeholder contributions affirmed and enhanced the foundational theoretical principles and provided validation of the final product for the target population. PMID:25276768

  15. Assisted annotation of medical free text using RapTAT

    PubMed Central

    Gobbel, Glenn T; Garvin, Jennifer; Reeves, Ruth; Cronin, Robert M; Heavirland, Julia; Williams, Jenifer; Weaver, Allison; Jayaramaraja, Shrimalini; Giuse, Dario; Speroff, Theodore; Brown, Steven H; Xu, Hua; Matheny, Michael E

    2014-01-01

    Objective To determine whether assisted annotation using interactive training can reduce the time required to annotate a clinical document corpus without introducing bias. Materials and methods A tool, RapTAT, was designed to assist annotation by iteratively pre-annotating probable phrases of interest within a document, presenting the annotations to a reviewer for correction, and then using the corrected annotations for further machine learning-based training before pre-annotating subsequent documents. Annotators reviewed 404 clinical notes either manually or using RapTAT assistance for concepts related to quality of care during heart failure treatment. Notes were divided into 20 batches of 19–21 documents for iterative annotation and training. Results The number of correct RapTAT pre-annotations increased significantly and annotation time per batch decreased by ∼50% over the course of annotation. Annotation rate increased from batch to batch for assisted but not manual reviewers. Pre-annotation F-measure increased from 0.5 to 0.6 to >0.80 (relative to both assisted reviewer and reference annotations) over the first three batches and more slowly thereafter. Overall inter-annotator agreement was significantly higher between RapTAT-assisted reviewers (0.89) than between manual reviewers (0.85). Discussion The tool reduced workload by decreasing the number of annotations needing to be added and helping reviewers to annotate at an increased rate. Agreement between the pre-annotations and reference standard, and agreement between the pre-annotations and assisted annotations, were similar throughout the annotation process, which suggests that pre-annotation did not introduce bias. Conclusions Pre-annotations generated by a tool capable of interactive training can reduce the time required to create an annotated document corpus by up to 50%. PMID:24431336

  16. Reliability assurance program and its relationship to other regulations

    SciTech Connect

    Polich, T.J.

    1994-12-31

    The need for a safety-oriented reliability effort for the nuclear industry was identified by the U.S. Nuclear Regulatory Commission (NRC) in the Three Mile Island Action Plan (NUREG-0660) Item II.C.4. In SECY-89-013, {open_quotes}Design Requirements Related to the Evolutionary ALWR,{close_quotes} the staff stated that the reliability assurance program (RAP) would be required for design certification to ensure that the design reliability of safety-significant structures, systems, and components (SSCs) is maintained over the life of a plant. In November 1988, the staff informed the advanced light water reactor (ALWR) vendors and the Electric Power Research Institute (EPRI) that it was considering this matter. Since that time, the staff has had numerous interactions with industry regarding RAP. These include discussions and subsequent safety evaluation reports on the EPRI utilities requirements document and for both Evolutionary Designs. The RAP has also been discussed in SECY-93-087, {open_quotes}Policy, Technical, and Licensing Issues Pertaining to Evolutionary and Advanced Light-Water Reactor (ALWR) Designs{close_quotes} and SECY-94-084, {open_quotes}Policy and Technical Issues Associated With the Regulatory Treatment of Non-Safety Systems in Passive Plant Designs.{close_quotes}

  17. Overview of the U.S. Department of Energy Formerly Utilized Sites Remedial Action Program - 12189

    SciTech Connect

    Clayton, Christopher; Kothari, Vijendra; Starr, Ken; Gillespie, Joey; Widdop, Michael

    2012-07-01

    The U.S. Department of Energy (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to address residual radiological contamination at sites where work was performed for the Manhattan Engineer District and U.S. Atomic Energy Commission. Initially, FUSRAP activities began with a records search for sites that had the potential to contain residual radiological contamination; 46 sites were identified that were eligible for and required remediation. Remedial action began in 1979. In 1997, Congress assigned responsibility for the remediation of FUSRAP sites to the U.S. Army Corps of Engineers (USACE). DOE retains responsibility for determining if sites are eligible for FUSRAP remediation and for providing long-term surveillance and maintenance (LTS and M) of remediated FUSRAP sites. DOE LTS and M activities are designed to ensure that FUSRAP sites remain protective of human health and the environment and to preserve knowledge regarding FUSRAP sites. Additional elements include eligibility determinations, transition of remediated sites from USACE to DOE, LTS and M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close coordination with USACE and regulators to ensure there is no loss of protectiveness when sites transition to DOE for LTS and M. Over the life of the FUSRAP program from 1974 to the present, DOE's primary mission and responsibility has been to ensure that FUSRAP sites remain protective of human health and the environment. In fulfilling this mission, the DOE program includes the following key elements: eligibility determinations, transition of remediated sites from USACE to DOE, LTS and M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close communication stakeholders as well as state and federal regulators. DOE

  18. Alternatives for management of wastes generated by the formerly utilized sites remedial action program and supplement

    SciTech Connect

    Gilbert, T.L.; Peterson, J.M.; Vocke, R.W.; Alexander, J.K.

    1983-03-01

    Alternatives for disposal or stabilization of the wastes generated by the US Department of Energy's Formerly Utilized Sites Remedial Action Program (FUSRAP) are identified and compared, with emphasis on the long-term aspects. These wastes consist of soil material and rubble containing trace amounts of radionuclides. A detailed pathway analysis for the dose to the maximally exposed individual is carried out using an adaptation of the natural analogue method. Comparisons of the different alternatives, based on the results of the pathway analysis and qualitative cost considerations, indicate that, if the hazard is such that the wastes must be removed and disposed of rather than stabilized in place, disposal by immediate dispersal is preferable to containment, and containment followed by slow planned dispersal is preferable to containment without dispersal. The Supplement presents refinements of work that was reported at the 1982 International Decommissioning Symposium. The new material consists of revisions of the estimates of the predicted potential dose to the maximally exposed individual and a more detailed comparative assessment of the radiological impacts of alternatives for management of wastes generated by the US Department of Energy's Formerly Utilized Sites Remedial Action Program (FUSRAP).

  19. [Uranium Mill Tailings Remedial Action Project Office Quality Assurance Program Plan

    SciTech Connect

    Not Available

    1992-06-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project was established to accomplish remedial actions at inactive uranium mill tailings sites in accordance with Public Law 95-604, the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA). The UMTRA Project's mission is to stabilize and control the residual radioactive materials at designated sites in a safe and environmentally sound manner so as to minimize or eliminate radiation health hazards to the public. The US Department of Energy (DOE) UMTRA Project Office (UMTRA PO) directs the overall project. Since these efforts may involve possible risks to public health and safety, a quality assurance (QA) program that conforms to the applicable criteria (set forth in the reference documents) has been established to control the quality of the work. This document, the Quality Assurance Program Plan (QAPP), brings into one document the essential criteria to be applied on a selective basis, depending upon the nature of the activity being conducted, and describes how those criteria shall be applied to the UMTRA Project. The UMTRA PO shall require each Project contractor to prepare and submit for approval a more detailed QAPP that is based on the applicable criteria of this QAPP and the referenced documents. All QAPPs on the UMTRA Project shall fit within the framework of this plan.

  20. Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group).

    PubMed

    Niu, Qingli; Bonsergent, Claire; Guan, Guiquan; Yin, Hong; Malandrin, Laurence

    2013-11-15

    Babesiosis is a frequent infection of animals worldwide by tick borne pathogen Babesia, and several species are responsible for ovine babesiosis. Recently, several Babesia motasi-like isolates were described in sheep in China. In this study, we sequenced the multigenic rap-1 gene locus of one of these isolates, Babesia sp. BQ1 Lintan. The RAP-1 proteins are involved in the process of red blood cells invasion and thus represent a potential target for vaccine development. A complex composition and organization of the rap-1 locus was discovered with: (1) the presence of 3 different types of rap-1 sequences (rap-1a, rap-1b and rap-1c); (2) the presence of multiple copies of rap-1a and rap-1b; (3) polymorphism among the rap-1a copies, with two classes (named rap-1a61 and rap-1a67) having a similarity of 95.7%, each class represented by two close variants; (4) polymorphism between rap-1a61-1 and rap-1a61-2 limited to three nucleotide positions; (5) a difference of eight nucleotides between rap-1a67-1 and rap-1a67-2 from position 1270 to the putative stop site of rap-1a67-1 which might produce two putative proteins of slightly different sizes; (6) the ratio of rap-1a copies corresponding to one rap-1a67, one rap-1a61-1 and one rap-1a61-2; (7) the presence of three different intergenic regions separating rap-1a, rap-1b and rap-1c; (8) interspacing of the rap-1a copies with rap-1b copies; and (9) the terminal position of rap-1c in the locus. A 31kb locus composed of 6 rap-1a sequences interspaced with 5 rap-1b sequences and with a terminal rap-1c copy was hypothesized. A strikingly similar sequence composition (rap-1a, rap-1b and rap-1c), as well as strong gene identities and similar locus organization with B. bigemina were found and highlight the conservation of synteny at this locus in this phylogenetic clade.