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Sample records for action program rap

  1. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  2. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  3. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  4. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  5. 40 CFR 270.68 - Remedial Action Plans (RAPs).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Remedial Action Plans (RAPs). 270.68 Section 270.68 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... § 270.68 Remedial Action Plans (RAPs). Remedial Action Plans (RAPs) are special forms of permits...

  6. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  7. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  8. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  9. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  10. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  11. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  12. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  13. 40 CFR 270.160 - When does my RAP become effective?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false When does my RAP become effective? 270... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.160 When does my RAP become effective? Your RAP becomes effective 30...

  14. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  15. 40 CFR 270.95 - How do I apply for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How do I apply for a RAP? 270.95... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.95 How do I apply for a RAP? To apply for a RAP, you must complete an...

  16. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false What is a RAP? 270.80 Section 270.80... ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  17. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  18. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  19. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false What is a RAP? 270.80 Section 270.80... ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  20. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  1. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  2. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  3. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  4. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  5. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What is a RAP? 270.80 Section 270.80... ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  6. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false What is a RAP? 270.80 Section 270.80... ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  7. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  8. 40 CFR 270.195 - When will my RAP expire?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false When will my RAP expire? 270.195... (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.195 When will my RAP...

  9. 40 CFR 270.80 - What is a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false What is a RAP? 270.80 Section 270.80... ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.80 What is a RAP? (a) A RAP is a special form of RCRA permit that you, as an owner...

  10. 40 CFR 270.100 - Who must obtain a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Who must obtain a RAP? 270.100 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.100 Who must obtain a RAP? When a facility or remediation waste management site...

  11. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  12. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  13. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  14. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  15. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  16. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  17. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  18. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  19. 40 CFR 270.125 - If I submit my RAP application as part of another document, what must I do?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false If I submit my RAP application as part... PERMIT PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.125 If I submit my RAP application as part of another document, what must I do? If you submit your application for a RAP as a part...

  20. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any...

  1. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  2. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  3. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  4. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  5. 40 CFR 270.185 - For what reasons may the Director choose to terminate my final RAP, or deny my renewal application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... choose to terminate my final RAP, or deny my renewal application? 270.185 Section 270.185 Protection of... PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified... final RAP, or deny my renewal application? The Director may terminate your final RAP on his...

  6. Region 1: Radiological Assistance Program (RAP). Revision 2, Part 1

    SciTech Connect

    Hull, A.P.; Kuehner, A.V.

    1993-10-01

    The Department of Energy`s Radiological Assistance Program (RAP) is established under DOE Order 5530.3 to: (a) Establish and maintain response plans and resources to provide radiological assistance to other Federal agencies, State, local, and tribal governments, and private groups requesting such assistance. (b) Assist State, local, and tribal jurisdictions in preparing for radiological emergencies. (c) In the event of a real, or potential radiological accident, provide resources and monitoring and assessment assistance to other federal agencies, State, local, and tribal Governments. This plan is an integral part of a nationwide program of regionally based radiological assistance which has been established by DOE. The Brookhaven Area Office is the Regional Coordinating Office (RCO) for the Radiological Assistance Program in DOE Region 1, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia.

  7. Hazardous Waste Remedial Actions Program: Remedial Actions Planning Program Quality Assurance Program Plan

    SciTech Connect

    Not Available

    1989-04-01

    The purpose of this Plan is to describe the quality assurance (QA) requirements for the RAP Program by identifying the quality elements to be controlled and specifying how they will be controlled. The activities for which control elements will be identified include those relating to: preparation, review, and approval of plans, reports, and studies; execution of field and analytical work by subcontractors and other agents; control of subcontractors and other agents during other phases of work; and actions internal to the RAP Program to ensure proper execution of projects.

  8. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  9. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  10. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  11. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  12. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  13. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  14. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  15. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  16. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  17. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  18. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  19. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  20. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  1. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  2. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  3. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  4. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  5. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  6. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  7. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  8. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  9. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  10. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  11. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  12. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  13. 40 CFR 270.150 - How will the Director make a final decision on my RAP application?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... decision on my RAP application? 270.150 Section 270.150 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.150 How will the Director make a final decision on my RAP application? (a) The Director must consider and respond to any significant...

  14. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  15. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  16. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  17. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  18. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  19. 40 CFR 270.215 - How are time periods in the requirements in this subpart and my RAP computed?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements in this subpart and my RAP computed? 270.215 Section 270.215 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.215 How are time periods in the requirements in this subpart and my RAP computed? (a) Any time period scheduled to begin...

  20. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  1. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  2. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  3. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  4. 40 CFR 270.90 - Does my RAP grant me any rights or relieve me of any obligations?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does my RAP grant me any rights or... PROGRAM Remedial Action Plans (RAPs) General Information § 270.90 Does my RAP grant me any rights or relieve me of any obligations? The provisions of § 270.4 apply to RAPs. (Note: The provisions of §...

  5. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  6. 40 CFR 270.225 - What must the State or EPA Region report about noncompliance with RAPs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... report about noncompliance with RAPs? 270.225 Section 270.225 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Operating Under Your Rap § 270.225 What must the State or EPA Region report about noncompliance with RAPs? The State or EPA Region must report noncompliance with...

  7. 40 CFR 270.165 - When may I begin physical construction of new units permitted under the RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of new units permitted under the RAP? 270.165 Section 270.165 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.165 When may I begin physical construction of new units permitted under the RAP? You must not begin physical construction of new...

  8. 40 CFR 270.175 - For what reasons may the Director choose to modify my final RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... choose to modify my final RAP? 270.175 Section 270.175 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.175 For what reasons may the Director choose to modify my final RAP? (a) The Director may...

  9. 40 CFR 270.170 - After my RAP is issued, how may it be modified, revoked and reissued, or terminated?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false After my RAP is issued, how may it be... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.170 After my RAP is issued, how may it be modified, revoked and reissued,...

  10. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RAP application be administratively appealed? 270.155 Section 270.155 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May the decision to approve or deny my RAP application be administratively appealed? (a) Any commenter on the...

  11. 40 CFR 270.130 - What is the process for approving or denying my application for a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... denying my application for a RAP? 270.130 Section 270.130 Protection of Environment ENVIRONMENTAL... PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.130 What is the process for approving or denying my application for a RAP? (a) If the Director tentatively finds that your...

  12. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  13. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  14. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  15. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  16. 40 CFR 270.205 - What happens if I have applied correctly for a RAP renewal but have not received approval by the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... correctly for a RAP renewal but have not received approval by the time my old RAP expires? 270.205 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.205 What happens if I have...

  17. 40 CFR 270.85 - When do I need a RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false When do I need a RAP? 270.85 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.85 When do I need a RAP? (a) Whenever you treat, store, or dispose of...

  18. 40 CFR 270.85 - When do I need a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false When do I need a RAP? 270.85 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.85 When do I need a RAP? (a) Whenever you treat, store, or dispose of...

  19. 40 CFR 270.85 - When do I need a RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false When do I need a RAP? 270.85 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.85 When do I need a RAP? (a) Whenever you treat, store, or dispose of...

  20. 40 CFR 270.85 - When do I need a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false When do I need a RAP? 270.85 Section...) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) General Information § 270.85 When do I need a RAP? (a) Whenever you treat, store, or dispose of...

  1. Partnering for environmental restoration: The Port Hope Harbour Remedial Action Plan (RAP)

    SciTech Connect

    Weston, S.M.C.

    1995-12-31

    A Remedial Action Plan (RAP) is being developed for Port Hope Harbour, one of 43 Areas of Concern (AOCs) identified by the International Joint Commission (IJC). The RAP, when implemented, will lead to the restoration and protection of desirable water conditions in Port Hope Harbour. The environmental concern associated with the harbor can be best viewed as a historical contaminated sediment problem. Approximately 90,000 m{sup 3} of sediment located in Port Hope Harbour`s turning basin and west slip are contaminated by uranium and thorium series radionuclides, heavy metals, and PCBs. There are several groups contributing to the development of the RAP. All of these groups have the common goal of developing an environmentally sound plan that reflects the views of the community. Strategic partnerships have been established that recognize the need to integrate and coordinate the efforts of all agencies, stakeholders, and the community. The objective is to develop an environmentally sound remediation plan through an efficient and effective management framework.

  2. Reinforcing Alcohol Prevention (RAP) Program: A Secondary School Curriculum to Combat Underage Drinking and Impaired Driving

    ERIC Educational Resources Information Center

    Will, Kelli England; Sabo, Cynthia Shier

    2010-01-01

    The Reinforcing Alcohol Prevention (RAP) Program is an alcohol prevention curriculum developed in partnership with secondary schools to serve their need for a brief, evidence-based, and straightforward program that aligned with state learning objectives. Program components included an educational lesson, video, and interactive activities delivered…

  3. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  4. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  5. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  6. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  7. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  8. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  9. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  10. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... addition to the draft RAP or notice of intent to deny? 270.140 Section 270.140 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.140 What else must the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director...

  11. 40 CFR 270.145 - What are the procedures for public comment on the draft RAP or notice of intent to deny?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... comment on the draft RAP or notice of intent to deny? 270.145 Section 270.145 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.145 What are the procedures for public comment on the draft RAP or notice of intent to deny? (a) The Director must: (1)...

  12. Total quality management -- Remedial actions planning program

    SciTech Connect

    Petty, J.L.; Horne, T.E.

    1989-01-01

    This paper describes the management approach being taken within the Hazardous Waste Remedial Actions Program (HAZWRAP) Support Contractor Office (SCO) to ensure quality of services in a highly competitive waste management environment. An overview is presented of the contractor support role assigned to Martin Marietta Energy Systems, Inc., by the Department of Energy (DOE) national program for managing hazardous waste. The HAZWRAP SCO mission, organizational structure, and major programs are outlined, with emphasis on waste management planning for the DOE Work for Others (WFO) Program. The HAZWRAP SCO provides waste management technical support, via interagency agreements between DOE and various Department of Defense (DOD) agencies for DOD sponsors planning remedial response actions. The remainder of the paper focuses on how the concept of Total Quality Management is applied to the HAZWRAP Remedial Actions Planning (RAP) Program. The management challenge is to achieve quality on a ''system'' basis where all functional elements of program management synergistically contribute to the total quality of the effort. The quality assurance (QA) program requirements applied to the RAP Program and its subcontractors are discussed. The application of management principles in the areas of program management, procurement, and QA to achieve total quality is presented. 3 refs.

  13. An Action Research Study on the Influence of Gangsta Rap on Academic and Behavioral Issues of 5th Grade African-American Males

    ERIC Educational Resources Information Center

    Lewis, Shaun; Boes, Susan R.; Chibbaro, Julie S.

    2015-01-01

    This small action research study (ARS) began with a review of the literature examining the relationship of gangsta rap in regards to academic achievement, self-esteem, decision-making, identity issues and development of young African American males. The purpose of the ARS was to examine the correlation between gangsta rap and its influence on 5th…

  14. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  15. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  16. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  17. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  18. 40 CFR 270.180 - For what reasons may the Director choose to revoke and reissue my final RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... choose to revoke and reissue my final RAP? 270.180 Section 270.180 Protection of Environment... HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) How May My Rap Be Modified, Revoked and Reissued, Or Terminated? § 270.180 For what reasons may the Director choose to revoke and reissue my final...

  19. A demonstration of the applicability of implementing the enhanced Remedial Action Priority System (RAPS) for environmental releases

    SciTech Connect

    Whelan, G.; Droppo, J.G. Jr.; Strenge, D.L.; Walter, M.B.; Buck, J.W.

    1989-12-01

    The Remedial Action Priority System (RAPS) and the Multimedia Environmental Pollutant Assessment System (MEPAS) were developed to prioritize problems associated with potential releases of hazardous chemical and radioactive materials in a scientific and objective manner based on limited site information. This report documents the model testing efforts of the RAPS/MEPAS methodology for the atmospheric, surface water, groundwater, and exposure components. Comparisons are given of model outputs with measured data at three sites: the US Department of Energy's Mound facility in Ohio and Hanford facility in Washington, and a chromium-cadmium plating site in New York. The results show that the simulated magnitudes, spacial and temporal trends, and distributions of contaminants corresponded well with the measured data. 25 refs., 86 figs., 26 tabs.

  20. RAP: a computer program for exploring similarities in behavior sequences using random projections.

    PubMed

    Quera, Vicenç

    2008-02-01

    A computer program (RAP, for random projection) for exploring similarities between and within sequences of behavior is presented. Given a time window of a sequence, the program calculates a signature, a real-valued vector that is a random projection of the contents of the window (i.e., the codes occurring within it and their relative location, or onset and offset times) into an arbitrary K-dimensional space. Then, given two different time windows from the same sequence or from different sequences, their similarity is computed as an inverse function of the Euclidean distance between their respective signatures. By defining moving (overlapped or not overlapped) windows along each sequence and calculating similarities between every pair of windows from the two sequences, a map of similarities or possible recurrent patterns is obtained; the RAP program represents them as gray-level lattices, which are displayed as mouse-sensitive images in an HTML file. Computation of similarities is based on the random projection method, as presented by Mannila and Seppänen (2001), for the analysis of sequences of events. The program reads sequence data files in Sequential Data Interchange Standard (SDIS) format (Bakeman Quera, 1992,1995a).

  1. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Central Nervous System (CNS) contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here, we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in...

  2. Data base management activities for the Remedial Action Program at ORNL, calendar year 1987

    SciTech Connect

    Voorhees, L.D.; Hook, L.A.; Gentry, M.J.; McCord, R.A.; Faulkner, M.A.; Newman, K.A.; Owen, P.T.

    1988-05-01

    The Oak Ridge National Laboratory (ORNL) Remedial Action Program (RAP) was established in FY 1985 to apply corrective measures at areas contaminated with radioactive and/or hazardous chemical wastes. To achieve this goal, numerous and varied studies are being conducted to characterize the waste disposal sites. Environmental data collected in support of other programs at ORNL are also of use to RAP. These studies are generating a voluminous amount of data on a scale unprecedented for ORNL. A computerized Data and Information Management System (DIMS) was developed for RAP to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated facilities and sites. 10 refs., 25 figs., 16 tabs.

  3. Affirmative Action Program Manual.

    ERIC Educational Resources Information Center

    Ventura County Community Coll. District, CA.

    Guidelines relating to the affirmative action program of the Ventura County Community College District are provided in this manual. Affirmative action is defined as, "A set of specific and result-oriented procedures to which a contractor commits himself/herself to apply every good faith effort. The objective of those procedures, plus such efforts,…

  4. Rap-Music Attitude and Perception Scale: A Validation Study

    ERIC Educational Resources Information Center

    Tyson, Edgar H.

    2006-01-01

    Objective: This study tests the validity of the Rap-music Attitude and Perception (RAP) Scale, a 1-page, 24-item measure of a person's thoughts and feelings surrounding the effects and content of rap music. The RAP was designed as a rapid assessment instrument for youth programs and practitioners using rap music and hip hop culture in their work…

  5. Data base management activities for the Remedial Action Program at ORNL: Calendar year 1988

    SciTech Connect

    Voorhees, L.D.; Hook, L.A.; Gentry, M.J.; McCord, R.A.; Faulkner, M.A.; Bledsoe, J.L.; Newman, K.A.; Owen, P.T.; Rosen, A.E.

    1989-04-01

    The ORNL Remedial Action Program (RAP) was established in 1985 in response to state and federal regulations mandating corrective actions at contaminated sites. To achieve this goal, numerous and varied studies are being conducted to characterize the type and extent of contamination. Environmental data collected in support of other programs at ORNL are also of use to RAP. Collectively, these studies are generating a voluminous amount of data. A computerized Data and Information Management System (DIMS) was developed for RAP to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated facilities and sites. The current DIMS and its role in supporting RAP during 1988 are described. The DIMS consists of three components: (1) the Numeric Data Base, (2) the Bibliographic Data Base, and (3) the Records Control Data Base. This report addresses all three data bases, but focuses on a description of the contents of the Numeric Data Base. The types of numeric data currently available are summarized in the tables and figures. More detailed information on the contents of the RAP Numeric Data Base has been assembled in a menu-driven format on IBM PC diskettes, which are available upon request. 6 refs.

  6. 40 CFR 270.155 - May the decision to approve or deny my RAP application be administratively appealed?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false May the decision to approve or deny my... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) EPA ADMINISTERED PERMIT PROGRAMS: THE HAZARDOUS WASTE PERMIT PROGRAM Remedial Action Plans (RAPs) Getting A Rap Approved § 270.155 May...

  7. Expert Teacher Action Program.

    ERIC Educational Resources Information Center

    Washington, Eva

    The expert teacher action program is to improve classroom teaching performance. The program has been tested in workshop sessions involving more than 1,200 educators representing 50 school districts. A set of standards, consisting of 25 variables, lead to the definition of expert teaching. Each variable deals with a major aspect of the duties of…

  8. Data and Information Management System for the ORNL Remedial Action Program

    SciTech Connect

    Voorhees, L.D.; Hook, L.A.; Gentry, M.J.; Owen, P.T.; Newman, K.A.; McCord, R.A.; Faulkner, M.A.; Bledsoe, J.L.

    1988-01-01

    A Remedial Action Program (RAP) was established in FY 1985 at Oak Ridge National Laboratory (ORNL) to provide corrective measures at areas contaminated with radioactive and/or hazardous chemical wastes. To achieve this goal, numerous and varied studies are being conducted to characterize the waste disposal sites. Environmental data collected in support of other programs at ORNL are also of use to RAP. Collectively, these studies are generating a voluminous amount of data on a scale unprecedented for ORNL. A computerized Data and Information Management System (DIMS) was developed to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated sites and facilities. The current DIMS and its role in supporting RAP are described. The DIMS consists of three components: (1) the Bibliographic Data Base, (2) the Records Control Data Base, and (3) the Numeric Data Base. This paper/poster emphasizes the Numeric Data Base, including its development and organization, and also summarizes the status of other activities associated with management and use of such data (i.e., bibliographic information, records control, geographic information, and quality assurance). The types of data currently available have been summarized, and a synopsis of the contents of the RAP numeric data base has been compiled in a menu-driven program available on PC diskettes. The synopsis will be demonstrated at the conference. 4 refs., 5 figs.

  9. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  10. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  11. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  12. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  13. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  14. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  15. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  16. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  17. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  18. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  19. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  20. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  1. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  2. 40 CFR 270.135 - What must the Director include in a draft RAP?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... draft RAP? 270.135 Section 270.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Action Plans (RAPs) Getting A Rap Approved § 270.135 What must the Director include in a draft RAP? If the Director prepares a draft RAP, it must include the: (a) Information required under §...

  3. 40 CFR 270.110 - What must I include in my application for a RAP?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for a RAP? 270.110 Section 270.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Applying for A Rap § 270.110 What must I include in my application for a RAP? You must include the following information in your application for a RAP: (a) The name, address,...

  4. 40 CFR 270.210 - What records must I maintain concerning my RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... concerning my RAP? 270.210 Section 270.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.210 What records must I maintain concerning my RAP? You are required to keep records of: (a) All data used to complete RAP applications and...

  5. 40 CFR 270.120 - To whom must I submit my RAP application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false To whom must I submit my RAP... Action Plans (RAPs) Applying for A Rap § 270.120 To whom must I submit my RAP application? You must submit your application for a RAP to the Director for approval....

  6. The Recruit Assessment Program (RAP) Experience With Adverse Childhood Experiences (ACE) Questions

    DTIC Science & Technology

    2006-02-22

    recruits in San Diego. It differs from previous versions in that it asks additional education questions, such as history of homeschooling , school...Albuquerque, New Mexico . 17. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159–174. 18...Protection Conference, August 11–17, 2003, Albuquerque, New Mexico . 14 15 Table 4. Top 10 RAP Questions Fort Jackson, SC, Participants “Skipped or

  7. Data base management activities for the Remedial Action Program at Oak Ridge National Laboratories (ORNL)

    SciTech Connect

    Hook, L.A.; Voorhees, L.D.; Gentry, M.J.; Faulkner, M.A.; Shaakir-Ali, J.A.; Newman, K.A.; McCord, R.A.; Goins, L.F.; Owen, P.T.

    1990-07-01

    The Oak Ridge National Laboratory (ORNL) Remedial Action Program (RAP) was established in 1985 in response to state and federal regulations requiring comprehensive control over facility discharges and cleanup of contaminated sites. A computerized Data and Information Management System (DIMS) was developed for RAP to (1) provide a centralized repository for data pertinent to RAP and (2) provide support for the investigations and assessments leading to the long-term remediation of contaminated facilities and sites. The current status of DIMS and its role in supporting RAP during 1989 are described. The DIMS consists of three components: (1) the Numeric Data Base, (2) the Bibliographic Data Base, and (3) the Records Control Data Base. This report addresses all three data bases, but focuses on the contents of the Numeric Data Base. Significant progress was made last year with the geographic information system (GIS) and ARC/INFO, which can be interfaced with SAS/GRAPH to provide combined mapping and statistical graphic products. Several thematic layers of GIS data for the Oak Ridge Reservation are now available. 18 refs., 8 figs., 19 tabs.

  8. ORNL Remedial Action Program strategy (FY 1987-FY 1992)

    SciTech Connect

    Trabalka, J.R.; Myrick, T.E.

    1987-12-01

    Over 40 years of Oak Ridge National Laboratory (ORNL) operations have produced a diverse legacy of contaminated inactive facilities, research areas, and waste disposal areas that are potential candidates for remedial action. The ORNL Remedial Action Program (RAP) represents a comprehensive effort to meet new regulatory requirements and ensure adequate protection of on-site workers, the public, and the environment by providing appropriate corrective measures at over 130 sites contaminated historically with radioactive, hazardous chemical, or mixed wastes. A structured path of program planning, site characterization, alternatives assessment, technology development, engineering design, continued site maintenance and surveillance, interim corrective action, and eventual site closure or decommissioning is required to meet these objectives. This report documents the development of the Remedial Action Program, through its preliminary characterization, regulatory interface, and strategy development activities. It provides recommendations for a comprehensive, long-term strategy consistent with existing technical, institutional, and regulatory information, along with a six-year plan for achieving its initial objectives. 53 refs., 8 figs., 12 tabs.

  9. The Fluids RAP

    NASA Astrophysics Data System (ADS)

    Nedyalkov, Ivaylo

    2016-11-01

    After fifteen years of experience in rap, and ten in fluid mechanics, "I am coming here with high-Reynolds-number stamina; I can beat these rap folks whose flows are... laminar." The rap relates fluid flows to rap flows. The fluid concepts presented in the song have varying complexity and the listeners/viewers will be encouraged to read the explanations on a site dedicated to the rap. The music video will provide an opportunity to share high-quality fluid visualizations with a general audience. This talk will present the rap lyrics, the vision for the video, and the strategy for outreach. Suggestions and comments will be welcomed.

  10. System 80+ D-RAP, a communication tool

    SciTech Connect

    Siegmann, E.R.; Mody, A.A.

    1994-12-31

    The purpose of {open_quotes}RAP{close_quotes} music is to communicate, and the purpose of D-RAP is to foster communication between the probabilistic risk assessment (PRA) group, designers, and the future combined operating license (COL) applicant. This is to ensure that the design is self-consistent and integrated with the procurement process. The designer reliability assurance program (D-RAP) is the first part of the RAP. The goals of the D-RAP are to have risk-significant systems, structures, and components (SSCs) identified and considered in the detail design and procurement phases and to maintain consistency between PRA and design. Plant safety is maintained throughout the design phase, and pertinent information is passed on to the COL applicant. The operations RAP (O-RAP) covers the plant operation and maintenance.

  11. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  12. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  13. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  14. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  15. 40 CFR 270.220 - How may I transfer my RAP to a new owner or operator?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How may I transfer my RAP to a new... Remedial Action Plans (RAPs) Operating Under Your Rap § 270.220 How may I transfer my RAP to a new owner or operator? (a) If you wish to transfer your RAP to a new owner or operator, you must follow the...

  16. Programming Tool-Use Actions

    ERIC Educational Resources Information Center

    Massen, Cristina; Prinz, Wolfgang

    2007-01-01

    When humans plan to execute a tool-use action, they can only specify the bodily movement parameters by taking into account the external target or goal of the tool-use action and the target-movement mapping implemented by the tool. In this study, the authors used the movement precuing method to investigate how people prepare for actions made with…

  17. Structural basis of Rap phosphatase inhibition by Phr peptides.

    PubMed

    Gallego del Sol, Francisca; Marina, Alberto

    2013-01-01

    Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation, by inhibiting the RR components involved in these pathways. Despite the high degree of sequence homology, Rap proteins exert their activity by two completely different mechanisms of action: inducing RR dephosphorylation or blocking RR binding to its target promoter. However the regulatory mechanism involving Rap proteins is even more complex since Rap activity is antagonized by specific signaling peptides (Phr) through a mechanism that remains unknown at the molecular level. Using X-ray analyses, we determined the structure of RapF, the anti-activator of competence RR ComA, alone and in complex with its regulatory peptide PhrF. The structural and functional data presented herein reveal that peptide PhrF blocks the RapF-ComA interaction through an allosteric mechanism. PhrF accommodates in the C-terminal tetratricopeptide repeat domain of RapF by inducing its constriction, a conformational change propagated by a pronounced rotation to the N-terminal ComA-binding domain. This movement partially disrupts the ComA binding site by triggering the ComA disassociation, whose interaction with RapF is also sterically impaired in the PhrF-induced conformation of RapF. Sequence analyses of the Rap proteins, guided by the RapF-PhrF structure, unveil the molecular basis of Phr recognition and discrimination, allowing us to relax the Phr specificity of RapF by a single residue change.

  18. BSE Rap: intergenerational ties to save lives.

    PubMed

    Ehmann, J L

    1993-09-01

    This article presents an innovative public-education strategy that was created to promote breast health awareness and early breast cancer detection among minority and low-income adolescent females. Given the importance of teaching breast self-examination (BSE), program development focused on creation of the BSE Rap, a lively music-video presentation. Increasing adolescents' knowledge and awareness of BSE is viewed as a springboard for disseminating information to their mothers and grandmothers. Funding was obtained for production of a video and a breast health diary, which are the program's key components. Marketing strategies included contacts with community organizations and healthcare professionals. Program evaluations reveal that the BSE Rap serves as a positive motivator for participants to discuss BSE and mammography with their mothers and grandmothers. The BSE Rap offers oncology nurses the opportunity to save lives using a unique and creative tool that focuses on intergenerational ties.

  19. Lawrence Berkeley Laboratory Affirmative Action Program. Revised

    SciTech Connect

    1995-06-01

    The Lawrence Berkeley Laboratory`s Affirmative Action Program (AAP) serves as a working document that describes current policies, practices, and results in the area of affirmative action. It represents the Laboratory`s framework for an affirmative approach to increasing the representation of people of color and women in segments of our work force where they have been underrepresented and taking action to increase the employment of persons with disabilities and special disabled and Vietnam era veterans. The AAP describes the hierarchy of responsibility for Laboratory affirmative action, the mechanisms that exist for full Laboratory participation in the AAP, the policies and procedures governing recruitment at all levels, the Laboratory`s plan for monitoring, reporting, and evaluating affirmative action progress, and a description of special affirmative action programs and plans the Laboratory has used and will use in its efforts to increase the representation and retention of groups historically underrepresented in our work force.

  20. Rap Music in the Classroom?

    ERIC Educational Resources Information Center

    Anderson, Edward

    1993-01-01

    Discusses the background of rap music, its definition, its themes and messages, and rap as a blend of language and music. Offers ideas for its use in the classroom as a way to motivate and instruct students. (SR)

  1. [Civic Achievement Award Program (CAAP) in Action.

    ERIC Educational Resources Information Center

    Close Up Foundation, Arlington, VA.

    This document consists of a student resource book entitled "CAAP in Action: The Environment" and an instructor guide entitled "CAAP in Action". CAAP is a program developed by the Close Up Foundation, a nonprofit, nonpartisan civic education organizations, in cooperation with the National Association of Elementary School…

  2. AAPS/RAPS/CAPRA collaborative program: exploring the challenges of drug regulation in a global environment: clinical concerns.

    PubMed

    Martinez, Marilyn N; McGilveray, Iain

    2003-10-23

    Globalization of the pharmaceutical industry has led to a need to harmonize the regulatory requirements governing the marketing of medicinal products. To minimize the barriers impeding global drug product registration, the International Conference on the Harmonization of Technical Requirements of Pharmaceuticals for Human Use (ICH) was established in 1990. The ICH has developed a series of guidelines that reflect agreements reached by participating nations on aspects of the chemistry and clinical technical sections that will fulfill the regulatory requirements of these various jurisdications. Nevertheless, there continue to be points of divergent perspectives and barriers that can impede the use of foreign clinical data. Given the importance of these issues, the Regulatory Science (RS) section of the American Association of Pharmaceutical Scientists (AAPS), in conjunction with the Regulatory Affairs Professional Society (RAPS) and the Canadian Association of Professional Regulatory Affairs (CAPRA) cosponsored a public forum on this topic. This manuscript provides a summary of the speaker presentations and audience discussions regarding the design of clinical trials and the extrapolation of results from these trials to support international drug registration.

  3. Library Programs. LSCA Programs: An Action Report.

    ERIC Educational Resources Information Center

    Office of Educational Research and Improvement (ED), Washington, DC.

    The seven narrative reports featured in this publication detail the accomplishments, in seven key areas, of State Grant Programs (Titles I, II, and III) funded by the Library Services and Construction Act (LSCA). These descriptions of state and local library activities, demonstrating how libraries are meeting a variety of users' needs, are: (1)…

  4. MIGRANT ACTION PROGRAM. ANNUAL REPORT 1966.

    ERIC Educational Resources Information Center

    SANDAGE, MRS. RICHARD

    THIS REPORT REVIEWS IN DETAIL THE MIGRANT ACTION PROGRAM AS FUNDED BY THE OFFICE OF ECONOMIC OPPORTUNITY IN IOWA. DAY CARE SERVICES, SUMMER SCHOOLS, AND ADULT EDUCATION PROGRAMS WERE OFFERED IN FOUR CENTERS WITHIN A SEVEN COUNTY AREA. A STAFF OF SIX PROVIDED MEDICAL SERVICES IN 29 MIGRANT LABOR CAMPS. A DETAILED ANALYSIS OF THE COMPONENTS IN EACH…

  5. Teen Drinking Prevention Program. Community Action Guide.

    ERIC Educational Resources Information Center

    Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Substance Abuse Prevention.

    Preventing the use of alcohol and other drugs by young people is a critical issue for all Americans. This action guide is designed to help communities create programs that prevent the tragedies caused by underage drinking. It is intended as a tool that communities can use to create a broad-based public education program in which they can…

  6. Teen Drinking Prevention Program. Event Action Guide.

    ERIC Educational Resources Information Center

    Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Substance Abuse Prevention.

    Underage drinking presents a serious health risk not only to young people themselves but to entire communities. This program guide is designed to help communities establish their own underage drinking prevention programs. Community norms, actions, and attitudes toward alcohol affect young people, as do the ways in which alcohol is promoted.…

  7. Creative Technology and Rap

    ERIC Educational Resources Information Center

    Ch'ien, Evelyn

    2011-01-01

    This paper describes how a linguistic form, rap, can evolve in tandem with technological advances and manifest human-machine creativity. Rather than assuming that the interplay between machines and technology makes humans robotic or machine-like, the paper explores how the pressure of executing artistic visions using technology can drive…

  8. Squaring to the Rap!

    ERIC Educational Resources Information Center

    Adams, Deborah

    2006-01-01

    This article describes an approach to teaching square dance that is advantageous for both the teacher and students. Lessons in dance become more meaningful to students when the music and vocabulary is consistent with experiences in their own lives. When students create their own squaring to the rap, lessons become more student-centered,…

  9. RCRA corrective action program guide (Interim)

    SciTech Connect

    Not Available

    1993-05-01

    The US Department of Energy (DOE) is responsible for compliance with an increasingly complex spectrum of environmental regulations. One of the most complex programs is the corrective action program proposed by the US Environmental Protection Agency (EPA) under the authority of the Resource Conservation and Recovery Act (RCRA) as amended by the Hazardous and Solid Waste Amendments (HSWA). The proposed regulations were published on July 27, 1990. The proposed Subpart S rule creates a comprehensive program for investigating and remediating releases of hazardous wastes and hazardous waste constituents from solid waste management units (SWMUs) at facilities permitted to treat, store, or dispose of hazardous wastes. This proposed rule directly impacts many DOE facilities which conduct such activities. This guidance document explains the entire RCRA Corrective Action process as outlined by the proposed Subpart S rule, and provides guidance intended to assist those persons responsible for implementing RCRA Corrective Action at DOE facilities.

  10. Matching boxes: familiar size influences action programming.

    PubMed

    McIntosh, Robert D; Lashley, Gavin

    2008-01-01

    The perception/action model is the dominant account of the primary division of labour in the human visual pathway. Integral to this model is the idea that goal-directed actions are guided spatially by bottom-up vision, independent of perceptual recognition and top-down object knowledge. We question this idea by showing that the expected size of familiar objects (matchboxes) affects the amplitude of reaches made to grasp them, and the pre-shaping of the hand, even when binocular cues are available. This suggests that perceptual recognition routinely influences action programming.

  11. Service Learning: An Action Oriented Program Evaluation

    ERIC Educational Resources Information Center

    Kelley, George

    2013-01-01

    Service learning is an academic discipline that provides students with "hands-on" opportunities for developing skills in real-world, community-based projects that serve and benefit community members. This dissertation reflects an action-oriented process for improving the quality of the Service Learning Program at City University of…

  12. Environmental Educational Youth Action Task Program

    ERIC Educational Resources Information Center

    Ab Rahman, Nik Norulaini Nik; Omar, Fatehah Mohd; Kalia, Noorliza; Hasmi, Mohammad

    2008-01-01

    An educational environmental youth camp was held comprising of fifty one 16-year old secondary students and facilitated by volunteers from the university and Friends of the Earth, a non profit organization in Penang. A weekend camp on youth action task program was held at an isolated beach packed with activities that were structured towards…

  13. Review of U.S. EPA Office of Research and Development's Research Programs

    EPA Pesticide Factsheets

    A review report of the Office of Research and Development’s (ORD) Strategic Research Action Plans (StRAPs) and the cross-cutting program Roadmaps for Environmental Justice and Global Climate Change.

  14. EPA Response to Review of Office of Research and Development's Research Programs

    EPA Pesticide Factsheets

    EPA's response to the review report of the Office of Research and Development’s (ORD) Strategic Research Action Plans (StRAPs) and the cross-cutting program Roadmaps for Environmental Justice and Global Climate Change.

  15. Rap Music and Choral Education.

    ERIC Educational Resources Information Center

    Bitz, Michael

    1998-01-01

    Suggests choral teachers use rap music to promote student interest and to teach music basics, such as rhythm, pitch, harmony, and timbre. Maintains that students can write the arrangements allowing them to gain experience in notating. Identifies selected recordings and offers an example of how to use rap music. (CMK)

  16. YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.

    PubMed

    Schmid, Rainer; Meyer, Katharina; Spang, Rainer; Schittek, Birgit; Bosserhoff, Anja Katrin

    2013-01-01

    MIA/CD-RAP is a small, secreted protein involved in cartilage differentiation and melanoma progression. We recently revealed that p54(nrb) acts as a mediator of MIA/CD-RAP action to promote chondrogenesis and the progression of malignant melanoma. As the molecular mechanism of MIA/CD-RAP action in cartilage has not been defined in detail until now, we aimed to understand the regulation of p54(nrb) transcription in chondrogenesis. We concentrated on the previously described MIA/CD-RAP-dependent regulatory region in the p54(nrb) promoter and characterized the transcriptional regulation of p54(nrb) by MIA/CD-RAP in cartilage. A series of truncated p54(nrb) promoter constructs and mutagenesis analysis revealed that the transcription factor YBX1, which has not been investigated in chondrogenesis thus far, is the mediator of MIA/CD-RAP dependent activation of p54(nrb) transcription. A systematic analysis of genes carrying this binding site in their promoter region revealed further potential MIA/CD-RAP-regulated genes that have been implicated in cartilage differentiation. In summary, we described the effects of MIA/CD-RAP on transcriptional regulation in chondrocytes. Understanding the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis. Uncovering new downstream effectors that function via the activation of YBX1 supports the important role of MIA/CD-RAP in these processes.

  17. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary.... Included should be a brief discussion of the relationship of the Preliminary Action Program to...

  18. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Preliminary Action Program... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary.... Included should be a brief discussion of the relationship of the Preliminary Action Program to...

  19. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra.

    PubMed

    Guo, Xiao-Xi; An, Su; Yang, Yang; Liu, Ying; Hao, Qian; Xu, Tian-Rui

    2016-01-01

    Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy.

  20. Translation of the Risk Avoidance Partnership (RAP) for Implementation in Outpatient Drug Treatment Clinics.

    PubMed

    Weeks, Margaret R; Kostick, Kristin; Li, Jianghong; Dunn, Jennifer; McLaughlin, Paul; Richmond, Phil; Choudhury, Shonali; Obidoa, Chinekwu; Mosher, Heather; Martinez, Maria

    2015-01-01

    Scientific literature increasingly calls for studies to translate evidence-based interventions into real-world contexts balancing fidelity to the original design and fit to the new setting. The Risk Avoidance Partnership (RAP) is a health promotion intervention originally designed to train active drug users to become Peer Health Advocates. A theoretically driven approach was used to adapt RAP to fit implementation in outpatient methadone treatment clinics and pilot it with clinic patients. Ethnographic observations and process tracking documented the RAP translation and pilot experience, and clinic and community characteristics relevant to program implementation. Clinic administrators, staff, and patients were interviewed on their values, capacities, interest in RAP, perceived challenges of implementing RAP in drug treatment clinics, and experiences during the pilot. Findings indicated that RAP core components can be met when implemented in these settings and RAP can fit with the goals, interests, and other programs of the clinic. Balancing fidelity and fit requires recognition of the mutual impacts RAP and the clinic have on each other, which generate new interactions among staff and require ongoing specification of RAP to keep abreast of clinic and community changes. Collaboration of multiple stakeholders significantly benefited translation and pilot processes.

  1. Indiana's Comprehensive Action Plan for Adult Education Programs.

    ERIC Educational Resources Information Center

    Indiana State Dept. of Education, Indianapolis.

    Indiana's Comprehensive Action Plan (I-CAP) provides a framework for program excellence, accountability, and continuous improvement in adult education. The action plan includes guiding principles and benchmarks for quality programs. Adult education programs are evaluated annually on these 10 established principles of program quality: educational…

  2. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Recovery Action Program grant... INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration § 72.52 Recovery Action Program grant applications. The application procedure for Recovery Action...

  3. Optimal expression condition of recombinant RAP.

    PubMed

    Zhang, Jie; Zhang, Hong; Bi, Hao; Liu, Zhiguo; Guo, Jianli; Qu, Shen

    2007-02-01

    In order to construct the expression recombinant of human receptor associated protein (RAP), optimize its expression condition and obtain the recombinant protein after expression with high efficiency, two prokaryotic expression vectors-pT7-PL and pET-28a(+) were used to construct the expression recombinant containing RAP cDNA, and the expression efficiency of two kinds of expression E. coli of BL21 strains was compared. The effect of different induction conditions on the expression of recombinant RAP was observed. After recombinant protein was purified with Ni(+) -nitrilotriacetic acid (Ni(+) -NTA) affinity chromatogram, its binding ability with microphage was observed. The results showed that two recombinant plasmids both obtained high expression of RAP. The expression levels of RAP in plasmid pT7-PL-RAP in BL21 (DE3, plysS) strain were significantly higher than in BL21 (DE3) strain. The expression of pT7-PL-RAP in the presence of chloramphenicol was higher than in the absence of chloramphenicol, and most of the inducible expressed RAP was soluble. The RAP which was purified by Ni(+) -NTA resin could strongly bind with the RAW264.7 cells rich in low density lipoprotein receptor (LDLR) family receptors. It was concluded that the expression condition of recombinant RAP was optimized and functional RAP was obtained, which offered a good foundation for the further production of RAP as research tool.

  4. German Rap Music in the Classroom.

    ERIC Educational Resources Information Center

    Schmidt, Johannes

    2003-01-01

    Provides background information on German rap artists and bands and discusses how to implement the music in various classroom situations at all levels. Highlights some of the available material on German rap music and provides information on how to locate rap texts, information, and other material via the Internet and other sources. (Author/VWL)

  5. Action Research in EdD Programs in Educational Leadership

    ERIC Educational Resources Information Center

    Osterman, Karen; Furman, Gail; Sernak, Kathleen

    2014-01-01

    This exploratory study gathered information about the use of action research within doctor of education programs in educational leadership and explored faculty understanding of and perspectives on action research. Survey data established that action research is used infrequently to meet dissertation requirements. Contributing factors include lack…

  6. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Action program components. 72.11 Section 72.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.11...

  7. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Action program components. 72.11 Section 72.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.11...

  8. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Preliminary Action Program. 72.15 Section 72.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  9. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Preliminary Action Program. 72.15 Section 72.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  10. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Preliminary Action Program. 72.15 Section 72.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  11. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Preliminary Action Program. 72.15 Section 72.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  12. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Action program components. 72.11 Section 72.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.11...

  13. 36 CFR 72.15 - Preliminary Action Program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Preliminary Action Program. 72.15 Section 72.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.15...

  14. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Action program components. 72.11 Section 72.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.11...

  15. 36 CFR 72.11 - Action program components.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Action program components. 72.11 Section 72.11 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.11...

  16. Rap2b, a novel p53 target, regulates p53-mediated pro-survival function

    PubMed Central

    Zhang, Xinyue; He, Yunlong; Lee, Kyoung-Hwa; Dubois, Wendy; Li, Ziqing; Wu, Xiaolin; Kovalchuk, Alexander; Zhang, Weimin; Huang, Jing

    2013-01-01

    The tumor suppressor p53 is a critical regulator of apoptosis and cell cycle arrest/pro-survival. Upon DNA damage, p53 evokes both cell cycle arrest/pro-survival and apoptosis transcriptional programs. The ultimate cellular outcome depends on the balance of these two programs. However, the p53 downstream targets that mediate this cell fate decision remain to be identified. Using an integrative genomic approach, we identify Rap2b as a conserved p53-activated gene that counters p53-mediated apoptosis after DNA damage. Upon DNA damage, p53 directly binds to the promoter of Rap2b and activates its transcription. The reduction of Rap2b levels by small interference RNA sensitizes cells to DNA damage-induced apoptosis in a p53-dependent manner. Consistent with its pro-survival function, analysis of cancer genomic data reveals that Rap2b is overexpressed in many types of tumors. Anchorage-independent growth assays show that Rap2b has only weak transformation activity, suggesting that it is not an oncogene by itself. Together, our results identify Rap2b as a new player in the pro-survival program conducted by p53 and raise the possibility that targeting Rap2b could sensitize tumor cells to apoptosis in response to DNA damage. PMID:23535297

  17. Technology Education in Action: Outstanding Programs.

    ERIC Educational Resources Information Center

    International Technology Education Association, Reston, VA.

    This volume contains 10 articles describing middle school and high school technology education programs conducted in schools throughout the United States. Program descriptions, which are written by the teachers involved in the programs, are from schools in the following areas: Ann Arbor, Michigan; Chicago, Illinois; Pittsburg, Kansas; Salt Lake…

  18. 24 Command Fire Improvement Action Program Plan

    SciTech Connect

    GRIFFIN, G.B.

    2000-12-01

    Fluor Hanford (FH) is responsible for providing support to the Department of Energy Richland Operations Office (RL) in the implementation of the Hanford Emergency Preparedness (EP) program. During fiscal year 2000, a number of program improvements were identified from various sources including a major range fire (24 Command Fire). Evaluations of the emergency preparedness program have confirmed that it currently meets all requirements and that performance of personnel involved is good, however the desire to effect continuous improvement resulted in the development of this improvement program plan. This program plan defines the activities that will be performed in order to achieve the desired performance improvements.

  19. Action Research: Effective Marketing Strategies for a Blended University Program

    ERIC Educational Resources Information Center

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  20. Numerical simulation of rip-raps with the distinct element method

    NASA Astrophysics Data System (ADS)

    Mittelbach, Livia

    2013-06-01

    and costal shores. They have to resist hydraulic loads such as ship and wind induced waves, tidal and ship induced currents, tidal varying water levels and storm surges. The numerical modelling of rip-rap revetments is undertaken by using the Distinct Element Method in three dimensions. With the DEM rip-rap stones can be modelled as autonomous objects with any degrees of freedom. Typical shapes of stones are formed by using clumped spherical particles. A method for the generation of the rip-rap stones based on geometrical and probabilistic parameters has been developed in order to generate stones with a realistic size and mass distribution. The DEM program is coupled with a computational fluid dynamics program to account for the influence of the hydraulic loads on the rip-rap stones. The acting forces can be simulated realistically for waves, currents and tidal varying water levels. Field measurements and model tests serve as validation for the numerical model. Physical model tests are carried out in a hydraulic flume with an instrumented rip-rap section for the calibration of the numerical stones material parameters. The behaviour of the particles depends on properties such as density, friction coefficient, normal and shear stiffness as well as the accuracy of the numerical representation of the rip-rap stones. Influences on the accuracy of the modelling of rip-raps with regard to the variation of these parameters are examined by comparing the results of the physical flume tests and numerical model.

  1. Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells.

    PubMed

    Dong, Xiaoyun; Korch, Christopher; Meinkoth, Judy L

    2011-06-01

    Increases in Rap activity have been associated with tumor progression. Although activating mutations in Rap have not been described, downregulation of Rap1GAP is frequent in human tumors including thyroid carcinomas. In this study, we explored whether endogenous Rap1GAP expression could be restored to thyroid tumor cells. The effects of deacetylase inhibitors and a demethylating agent, individually and in combination, were examined in four differentiated and six anaplastic thyroid carcinoma (ATC) cell lines. Treatment with the structurally distinct histone deacetylase (HDAC) inhibitors, sodium butyrate and trichostatin A, increased Rap1GAP expression in all the differentiated thyroid carcinoma cell lines and in four of the six ATC cell lines. The demethylating agent, 5-aza-deoxycytidine, restored Rap1GAP expression in one anaplastic cell line and enhanced the effects of HDAC inhibitors in a second anaplastic cell line. Western blotting indicated that Rap2 was highly expressed in human thyroid cancer cells. Importantly, treatment with HDAC inhibitors impaired Rap2 activity in both differentiated and anaplastic tumor cell lines. The mechanism through which Rap activity is repressed appears to entail effects on the expression of multiple Rap regulators, including RapGEFs and RapGAPs. These results suggest that HDAC inhibitors may provide a tractable approach to impair Rap activity in human tumor cells.

  2. Action Implications in Adult Basic Education Programs.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus.

    Eight articles on adult basic education are presented. The articles adapted from 1971 workshop presentations are: Action Implications for ABE Directors by Alan Knox; ABE Budget Development, by Donald G. Butcher; Competent ABE Instructors, by William D. Dowling; Interview Techniques and Training, by Norman Kagan; Reading: The Basic in Adult Basic…

  3. Affirmative Action Training Program for Firemen.

    ERIC Educational Resources Information Center

    MacBain, Z. E.

    This paper summarizes the "Affirmative Action" training of unskilled minorities for jobs as firemen. The various training approaches undertaken are discussed; some were more successful than others. Hopefully, the information provided in this report can be used by other fire departments as a basis for developing their own minority "Affirmative…

  4. Affirmative Action Programs: A Current Perspective.

    ERIC Educational Resources Information Center

    Muhammad, Habibah P.

    Recent lawsuits and judgments brought against colleges and universities for enacting affirmative action policies are threatening to dismantle the core principles of the Bakke decision (Regents of the University of California v. Bakke) and undermine the Civil Rights Act of 1964. This paper discusses current issues and challenges that pertain to…

  5. THE LAY READER PROGRAM IN ACTION.

    ERIC Educational Resources Information Center

    BURKE, VIRGINIA M.

    IN 1960, THE WISCONSIN COUNCIL OF TEACHERS OF ENGLISH CONDUCTED AN INTERVIEW AND QUESTIONNAIRE SURVEY OF PARTICIPANTS IN TWO LAY-READER PROGRAMS AT THE SECONDARY LEVEL--(1) A PROGRAM AT RACINE IN ITS FIRST FULL SEMESTER IN WHICH LAY READERS CORRECTED AND EVALUATED, BUT DID NOT GRADE, APPROXIMATELY HALF OF THE THEMES FROM SELECTED CLASSES, AND (2)…

  6. The Windana Therapeutic Community's Action Adventure Program.

    ERIC Educational Resources Information Center

    Price, Richard; DeBever, Marijke

    The Windana Society is a drug and alcohol agency in Victoria (Australia) that operates, among other things, a residential drug rehabilitation program in a rural setting. The program utilizes a holistic approach that addresses health and physical fitness; education; vocational and re-integration support; and psychological, emotional, spiritual, and…

  7. Rap Music: An Education with a Beat from the Street.

    ERIC Educational Resources Information Center

    Powell, Catherine Tabb

    1991-01-01

    Examines rap music's origins as street music and poetry in the early 1970s and as an expression of Black youth experience. Discusses rap groups, women and Whites in rap, Christian rap, copyright disputes, and distribution difficulties. Rap is an informal educational medium that affects adolescents' values and attitudes. (JB)

  8. A novel neutralization sensitive and subdominant RAP-1-related antigen (RRA) is expressed by babesia bovis merozoites

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Objective: The Babesia bovis genome encodes a rap-1 related gene denominated RAP-1 related antigen (RRA). In this study, we analyzed the pattern of expression, immunogenicity and functional relevance of RRA. Methods: Phylogenetic analysis was performed using the program Phylip. Expression of rra wa...

  9. US Department of Energy Uranium Mill Tailings Remedial Action ground water Project. Revision 1, Version 1: Final project plan

    SciTech Connect

    Not Available

    1993-12-21

    The scope of the Project is to develop and implement a ground water compliance strategy for all 24 UMTRA processing sites. The compliance strategy for the processing sites must satisfy requirements of the proposed EPA ground water cleanup standards in 40 CFR Part 192, Subparts B and C (1988). This scope of work will entail the following activities, on a site-specific basis: Development of a compliance strategy based upon modification of the UMTRA Surface Project remedial action plans (RAP) or development of Ground Water Project RAPs with NRC and state or tribal concurrence on the RAP; implementation of the RAP to include establishment of institutional controls, where appropriate; institution of long-term verification monitoring for transfer to a separate DOE program on or before the Project end date; and preparation of completion reports and final licensing on those sites that will be completed prior to the Project end date.

  10. Science in action: An interdisciplinary science education program

    NASA Technical Reports Server (NTRS)

    Horton, Linda L.

    1992-01-01

    Science in Action is an education outreach program for pre-collegiate students. It is based on the concept that, in order to interest students in science, they must see science and scientists at work. The program encompasses the full range of scientific disciplines - the core sciences, engineering, and mathematics. A unique aspect of the program is the involvement and support of scientists and engineers representing local professional societies, industries, business, and academic institutions. An outline of the program is given.

  11. Regulation of Rap GTPases in mammalian neurons.

    PubMed

    Shah, Bhavin; Püschel, Andreas W

    2016-10-01

    Small GTPases are central regulators of many cellular processes. The highly conserved Rap GTPases perform essential functions in the mammalian nervous system during development and in mature neurons. During neocortical development, Rap1 is required to regulate cadherin- and integrin-mediated adhesion. In the adult nervous system Rap1 and Rap2 regulate the maturation and plasticity of dendritic spine and synapses. Although genetic studies have revealed important roles of Rap GTPases in neurons, their regulation by guanine nucleotide exchange factors (GEFs) that activate them and GTPase activating proteins (GAPs) that inactivate them by stimulating their intrinsic GTPase activity is just beginning to be explored in vivo. Here we review how GEFs and GAPs regulate Rap GTPases in the nervous system with a focus on their in vivo function.

  12. Rap Music in School Counseling Based on Don Elligan's Rap Therapy

    ERIC Educational Resources Information Center

    Gonzalez, Tiphanie; Hayes, B. Grant

    2009-01-01

    In 2000, Don Elligan introduced Rap Therapy as a psychotherapeutic intervention for working with at-risk youths, primarily African American males whose identities were highly influenced by rap music. Rap music can engage a population of youth who often enter counseling apprehensively (Elligan 2000, 2004; Tillie-Allen, 2005). This article reviews…

  13. The GLOBE Program: Partnerships in Action

    NASA Astrophysics Data System (ADS)

    Henderson, S.; Kennedy, T.; Lemone, M.; Blurton, C.

    2004-12-01

    The GLOBE Program is a worldwide science and education partnership endeavor designed to increase scientific understanding of Earth as a system, support improved student achievement in science and math, and enhance environmental awareness through inquiry-based learning activities. GLOBE began on the premise that teachers and their students would partner with scientists to collect and analyze environmental data using specific protocols in five study areas - atmosphere, soils, hydrology, land cover, and phenology. As the GLOBE network grew, additional partnerships flourished making GLOBE an unprecedented collaboration of individuals worldwide - primary, secondary, and tertiary students, teachers and teacher educators, scientists, government officials, and others - to improve K-12 education. Since its inception in 1994, more than one million students in over 14,000 schools around the world have taken part in The GLOBE Program. The GLOBE Web site (http://www.globe.gov) is the repository for over 11 million student-collected data measurements easily accessible to students and scientists worldwide. Utilizing the advantages of the Internet for information sharing and communication, GLOBE has created an international community. GLOBE enriches students by giving them the knowledge and skills that they will need to become informed citizens and responsible decision-makers in an increasingly complex world. Understanding that all members of a community must support change if it is to be sustainable, GLOBE actively encourages the development of GLOBE Learning Communities (GLCs) which are designed to get diverse stakeholder groups involved in a local or regional environmental issue. Central to the GLC is the engagement of local schools. GLCs go beyond individual teachers implementing GLOBE in the isolation of their classrooms. Instead, the GLC brings multiple teachers and grade levels together to examine environmental issues encouraging the participation of a broad range of

  14. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  15. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  16. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  17. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  18. 48 CFR 922.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Affirmative action programs. 922.804 Section 922.804 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Equal Employment Opportunity...

  19. Long-Term Effects of the Positive Action Program.

    ERIC Educational Resources Information Center

    Flay, Brian R.; Allred, Carol G.

    2003-01-01

    Used a matched-schools design, school-level achievement, and disciplinary data to evaluate the effectiveness of the elementary-level Positive Action program on students' performance and behavior over time. Results indicated that program participation improved student behavior, school involvement, and academic achievement into high school. The…

  20. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Corrective action programs. 192.33 Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards...

  1. Rap Lyrics: Instruments for Language Arts Instruction.

    ERIC Educational Resources Information Center

    Jeremiah, Milford A.

    1992-01-01

    Offers suggestions for using rap lyrics to teach language skills. A brief overview of the sociocultural dimension of rap music and its literature, a theoretical orientation for the instructional methodology, and a curriculum model are presented. The prevalence of these musical forms can make them a valuable aid. (SLD)

  2. Library Programs. LSCA Programs: An Action Report II.

    ERIC Educational Resources Information Center

    Office of Educational Research and Improvement (ED), Washington, DC.

    The eight reports featured in this publication detail the accomplishments of the State Grant Program (Titles I through IV) funded by the Library Services and Construction Act (LSCA). Written by members of the Public Library Support Staff, these descriptions are based on state and local library reports on how they meet a variety of users' needs.…

  3. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... Action Programs § 60-2.17 Additional required elements of affirmative action programs. In addition to the elements required by § 60-2.10 through § 60-2.16, an acceptable affirmative action program must include...

  4. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... requirements. 72.16 Section 72.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary... and services offered, and the providers (public agency or private sector). (d) Statement of...

  5. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... requirements. 72.16 Section 72.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary... and services offered, and the providers (public agency or private sector). (d) Statement of...

  6. 36 CFR 72.16 - Preliminary Action Program requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... requirements. 72.16 Section 72.16 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs § 72.16 Preliminary... and services offered, and the providers (public agency or private sector). (d) Statement of...

  7. 40 CFR 264.100 - Corrective action program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 264.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.100 Corrective action program. An owner or...

  8. 40 CFR 264.100 - Corrective action program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 264.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.100 Corrective action program. An owner or...

  9. 40 CFR 264.100 - Corrective action program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 264.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.100 Corrective action program. An owner or...

  10. 40 CFR 264.100 - Corrective action program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 264.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.100 Corrective action program. An owner or...

  11. 40 CFR 264.100 - Corrective action program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 264.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.100 Corrective action program. An owner or...

  12. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Recovery Action Program grant applications. 72.52 Section 72.52 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  13. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Recovery Action Program grant applications. 72.52 Section 72.52 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  14. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Recovery Action Program grant applications. 72.52 Section 72.52 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  15. 36 CFR 72.52 - Recovery Action Program grant applications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Recovery Action Program grant applications. 72.52 Section 72.52 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  16. A Participatory Action Research Approach To Evaluating Inclusive School Programs.

    ERIC Educational Resources Information Center

    Dymond, Stacy K.

    2001-01-01

    This article proposes a model for evaluating inclusive schools. Key elements of the model are inclusion of stakeholders in the evaluation process through a participatory action research approach, analysis of program processes and outcomes, use of multiple methods and measures, and obtaining perceptions from diverse stakeholder groups. (Contains…

  17. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes.

    PubMed

    Estrada, Kristine; Fisher, Carl; Blacklow, Stephen C

    2008-02-12

    The receptor-associated protein (RAP) functions as an escort protein for receptors of the low-density lipoprotein receptor (LDLR) family by preventing premature intracellular binding of ligands and assisting with delivery of mature receptors to the cell surface. The modulation of affinity by pH is believed to play an important role in the escort function of RAP, because RAP binds tightly to proteins of the LDLR family at near-neutral pH early in the secretory pathway where its high affinity precludes premature binding of ligands but then dissociates from bound receptors at the lower pH of the Golgi compartment. The third domain of RAP (RAP-D3), which forms a three-helix bundle, is sufficient to reconstitute the escort activity. Here, we test the hypothesis that low-pH induced unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. First, variants of RAP-D3 resistant to low pH-induced unfolding were constructed by replacing interior histidine residues with phenylalanines. In contrast to native RAP-D3, which exhibits an unfolding pKa of 6.3 and a Tm of 42 degrees C, the most hyperstable variant of RAP-D3, in which four histidine residues are replaced with phenylalanine, has an unfolding pKa of 4.8, and a Tm of 58 degrees C. The phenylalanine substitutions in RAP-D3 confer increased stability to pH-induced dissociation of complexes formed between RAP-D3 and a two-repeat fragment of the LDLR (LA3-4). When introduced into full-length RAP, the four mutations that confer hyperstability on RAP-D3 interfere with transport of endogenous LRP-1 to the cell surface in a dominant negative fashion under conditions where expression of normal RAP has no effect on LRP-1 transport. Our studies support a model in which low pH-dependent unfolding of RAP-D3 facilitates dissociation of RAP from the LA repeats of LDLR family proteins in the mildly acidic pH of the Golgi.

  18. Environmental Education in Action - I: Case Studies of Selected Public School and Public Action Programs.

    ERIC Educational Resources Information Center

    Schoenfeld, Clay, Ed.; Disinger, John, Ed.

    This publication presents a collection of 26 environmental education case studies recognized as being representative of curriculum materials and/or projects. Contained are action programs that can serve as models for the classroom teacher, principal, curriculum consultant, superintendent, state department official, or teacher educators in the…

  19. Hazardous Waste Remedial Actions Program annual progress report, FY 1990

    SciTech Connect

    Not Available

    1990-12-01

    The Hazardous Waste Remedial Actions Programs (HAZWRAP), a unit of Martin Marietta Energy Systems, Inc., supports the Department of Energy (DOE) Oak Ridge Operations Office in broadly environmental areas, especially those relating to waste management and environmental restoration. HAZWRAP comprises six program areas, which are supported by central administrative and technical organizations. Existing programs deal with airborne hazardous substances, pollution prevention, remedial actions planning, environmental restoration, technology development, and information and data systems. HAZWRAP's mission to develop, promote, and apply-cost-effective hazardous waste management and environmental technologies to help solve national problems and concerns. HAZWRAP seeks to serve as integrator for hazardous waste and materials management across the federal government. It applies the unique combination of research and development (R D) capabilities, technologies, management expertise, and facilities in the Energy Systems complex to address problems of national importance. 24 figs., 10 tabs.

  20. Current activities handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-27

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the activities each of the thirteen state legislatures potentially affected by the Formerly Utilized Sites Remedial Action Program. It contains a description of the state legislative procedural rules and a schedule of each legislative session; a summary of pending relevant legislation; the name and telephone number of legislative and state agency contacts; and the full text of all bills identified.

  1. Site action plan for maintenance management program. Revision D

    SciTech Connect

    Pearson, A.W.

    1993-11-30

    (DOE) Order 4330.4B, ``Maintenance Management Program`` requires each site to develop a Site Action Plan for implementing a Maintenance Management Program. Nonnuclear facilities are required to address the 32 elements of Chapter 1: Guidelines for the Conduct of Maintenance at DOE Nonnuclear Facilities. This document details the degree of implementation for each element, and the Martin Marietta Specialty Components, Inc., plan for implementation of the items which remain to be completed. The original Pinellas Plant Maintenance Management Program Site Action Plan (Issue A) was completed March 27, 1991. The format was modified per DOE request and it was resubmitted as Issue B and approved by AL September 16, 1991. Issue C was submitted, and approved December 20, 1992. The most significant achievement during FY-93 were the implementation of plant wide Graded Approach, and Configuration Control programs. The methodologies for performing these activities were developed, and pilot programs were implemented to verify their effectiveness. Plant wide implementation of both programs is progressing on a high priority basis. The formalized method for grading equipment and facilities provides a basis for establishing uniform, risk based priorities. The risks involved are environment, safety, health and programmatic mission. Other achievements for FY-93, include the establishment of procedures for the decommissioning, and down-grading of facilities, improved work control, improved work performance reporting, improved quality plans, and improved operating procedures.

  2. The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.

    PubMed

    Kumar, Sachin; Xu, Juying; Kumar, Rupali Sani; Lakshmikanthan, Sribalaji; Kapur, Reuben; Kofron, Matthew; Chrzanowska-Wodnicka, Magdalena; Filippi, Marie-Dominique

    2014-08-25

    Neutrophils are the first line of cellular defense in response to infections and inflammatory injuries. However, neutrophil activation and accumulation into tissues trigger tissue damage due to release of a plethora of toxic oxidants and proteases, a cause of acute lung injury (ALI). Despite its clinical importance, the molecular regulation of neutrophil migration is poorly understood. The small GTPase Rap1b is generally viewed as a positive regulator of immune cell functions by controlling bidirectional integrin signaling. However, we found that Rap1b-deficient mice exhibited enhanced neutrophil recruitment to inflamed lungs and enhanced susceptibility to endotoxin shock. Unexpectedly, Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt activation and invadopodia-like protrusions. Akt inhibition in vivo suppressed excessive Rap1b-deficient neutrophil migration and associated endotoxin shock. The inhibitory action of Rap1b on PI3K signaling may be mediated by activation of phosphatase SHP-1. Thus, this study reveals an unexpected role for Rap1b as a key suppressor of neutrophil migration and lung inflammation.

  3. Massachusetts state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Massachusetts. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.

  4. Pennsylvania state information handbook formerly utilized sites remedial action program

    SciTech Connect

    Not Available

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  5. Ohio state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    Not Available

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Ohio. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.

  6. California state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of California. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.

  7. Maryland State information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Handbook Series Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Maryland. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  8. Oregon state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  9. Iowa state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-09

    This volume is one of a series produced under contract with the DOE, By Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Iowa. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.

  10. Oregon state information handbook formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administater, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  11. Florida state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1981-02-27

    This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the federal and state levels, the pertinent programs they administer, each affected state legislature, and current federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Florida. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  12. Pennsylvania state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and State levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  13. The Utility of the Racial Attitudes and Perceptions Survey (RAPS) for Assessing Impact of Race Relations Training Programs in the Military. Final Report. (Mar 73-Mar 74). Technical Paper 339.

    ERIC Educational Resources Information Center

    Hiett, Robert L.; And Others

    The Racial Attitudes and Perceptions Survey (RAPS) consists of four scales: perceived discrimination against blacks; attitude toward racial interaction; feelings of reverse racism; and racial climate. This instrument was administered to approximately 10,000 military personnel in a variety of research designs to determine the impact of race…

  14. Description of the Formerly Utilized Sites Remedial Action Program

    SciTech Connect

    Not Available

    1980-09-01

    The background and the results to date of the Department of Energy program to identify and evaluate the radiological conditions at sites formerly utilized by the Corps of Engineers' Manhattan Engineer District (MED) and the US Atomic Energy Commission (AEC) are summarized. The sites of concern were federally, privately, and institutionally owned and were used primarily for research, processing, and storage of uranium and thorium ores, concentrates, or residues. Some sites were subsequently released for other purposes without radiological restriction. Surveys have been conducted since 1974 to document radiological conditions at such sites. Based on radiological surveys, sites are identified in this document that require, or are projected to require, remedial action to remove potential restrictions on the use of the property due to the presence of residual low-level radioactive contamination. Specific recommendations for each site will result from more detailed environmental and engineering surveys to be conducted at those sites and, if necessary, an environmental impact assessment or environmental impact statement will be prepared. Section 3.0 describes the current standards and guidelines now being used to conduct remedial actions. Current authority of the US Department of Energy (DOE) to proceed with remedial actions and the new authority required are summarized. A plan to implement the Formerly Utilized Sites Remedial Action Program (FUSRAP) in accordance with the new authority is presented, including the objectives, scope, general approach, and a summary schedule. Key issues affecting schedule and cost are discussed.

  15. Effects of using nursing home residents to serve as group activity leaders: lessons learned from the RAP project.

    PubMed

    Skrajner, Michael J; Haberman, Jessica L; Camp, Cameron J; Tusick, Melanie; Frentiu, Cristina; Gorzelle, Gregg

    2014-03-01

    Previous research has demonstrated that persons with early to moderate stage dementia are capable of leading small group activities for persons with more advanced dementia. In this study, we built upon this previous work by training residents in long-term care facilities to fill the role of group activity leaders using a Resident-Assisted Programming (RAP) training regimen. There were two stages to the program. In the first stage, RAP training was provided by researchers. In the second stage, RAP training was provided to residents by activities staff members of long-term care facilities who had been trained by researchers. We examine the effects of RAP implemented by researchers and by activities staff member on long-term care resident with dementia who took part in these RAP activities. We also examined effects produced by two types of small group activities: two Montessori-based activities and an activity which focuses on persons with more advanced dementia, based on the work of Jitka Zgola. Results demonstrate that levels of positive engagement seen in players during RAP (resident-led activities) were typically higher than those observed during standard activities programming led by site staff. In general, Montessori-Based Dementia Programming® produced more constructive engagement than Zgola-based programming (ZBP), though ZBP did increase a positive form of engagement involving observing activities with interest. In addition, RAP implemented by activities staff members produced effects that were, on the whole, similar to those produced when RAP was implemented by researchers. Implications of these findings for providing meaningful social roles for persons with dementia residing in long-term care, and suggestions for further research in this area, are discussed.

  16. Regulating Rap small G-proteins in time and space.

    PubMed

    Gloerich, Martijn; Bos, Johannes L

    2011-10-01

    Signaling by the small G-protein Rap is under tight regulation by its GEFs and GAPs. These are multi-domain proteins that are themselves controlled by distinct upstream pathways, and thus couple different extra- and intracellular cues to Rap. The individual RapGEFs and RapGAPs are, in addition, targeted to specific cellular locations by numerous anchoring mechanisms and, consequently, may control different pools of Rap. Here, we review the various activating signals and targeting mechanisms of these proteins and discuss their contribution to the spatiotemporal regulation and biological functions of the Rap proteins.

  17. Science in Action'': An interdisciplinary science education program

    SciTech Connect

    Horton, L.L.

    1991-01-01

    Science in Action is an education outreach program for pre-collegiate students. It is based on the concept that, in order to interest students in science, they must see science and scientists at work. The program encompasses the full range of scientific disciplines -- the core sciences, engineering and mathematics. A unique aspect of the program is the involvement and support of scientists and engineers representing local professional societies, industries, businesses, and academic institutions. The goal of the presentations is to be highly interactive. The students have some hands on'' experiences and leave with a good feeling about science and engineering. To present a broad spectrum of role models, scientists and engineers were involved as presenters, guides, and exhibitors.

  18. Missouri State information handbook: formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Missouri. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature chairmen, and a summary of recent relevant legislative action; a description of the organization and structure of local governments affected by remedial action at the St. Louis area sites; a summary of relevant local ordinances and regulations; an identification of relevant public interest groups; a list of radio stations, television stations, and newspapers that provide public information to the St. Louis area or to Jefferson City; and the full text of relevant statutes and regulations.

  19. Rap Music and Its Violent Progeny: America's Culture of Violence in Context.

    ERIC Educational Resources Information Center

    Richardson, Jeanita W.; Scott, Kim A.

    2002-01-01

    Considers rap music as a creative expression and metaphorical offspring of America's well-established culture of violence, highlighting rap music in the context of a violent culture; violence in music; rap, cultural capital, and social reproduction; rap in the scholarly literature; political and judicial scrutiny of rap; and capitalism and rap.…

  20. Risk assessment in the DOE Assurance Program for Remedial Action

    SciTech Connect

    Marks, S.; Cross, F.T.; Denham, D.H.; Kennedy, W.E.; Stenner, R.D.

    1985-08-01

    This document provides information obtained during the performance of risk assessment tasks in support of the Assurance Program for Remedial Action (APRA) sponsored by the Office of Operational Safety of the Department of Energy. We have presented a method for the estimation of projected health effects at properties in the vicinity of uranium mill tailing piles due to transported tailings or emissions from the piles. Because radon and radon daughter exposure is identified as the principal factor contributing to health effects at such properties, the basis for estimating lung cancer risk as a result of such exposure is discussed in detail. Modeling of health risk due to a secondary pathway, ingestion of contaminated, home-grown food products, is also discussed since it is a potentially important additional source of exposure in certain geographic locations. Risk assessment methods used in various mill tailings reports are reviewed. The protocols for radiological surveys conducted in DOE-sponsored remedial action programs are critically reviewed with respect to their relevance to the needs of health risk estimation. The relevance of risk assessment to the APRA program is discussed briefly.

  1. Entrepreneurial Learning through Action: A Case Study of the Six-Squared Program

    ERIC Educational Resources Information Center

    Pittaway, Luke; Missing, Caroline; Hudson, Nigel; Maragh, Dean

    2009-01-01

    This paper explores the role of "action" in entrepreneurial learning and illustrates how programs designed to support action learning can enhance management development in entrepreneurial businesses. The paper begins by exploring action learning and the way "action" is conceived in different types of program. In the second part, the paper details…

  2. [Intervention programs in hospital nutrition: actions, design, components and implementation].

    PubMed

    Santana Porben, S; Barreto Penié, J

    2005-01-01

    Metabolic, Nutrient and Feeding Intervention Programs must become the methodological tool for dealing with the health problem posed by disease-associated-malnutrition on one side, and the "Bad Practices" affecting the nutritional status of the patient, on the other one. Programs like these ones should prescribe clear policies and actions in the three domains of contemporary medical practice: assistance, research and education. The fullfillment of these Program's objectives, and the relization of the implicit benefits, will only be possible if a methodological platform that armonically integrates elements of Continuous Education, Cost Analysis, Recording and Documentation, and Quality Control and Assurance, is created. The experience acumulated after the inception and conduction of the Intervention Program at the Clinical-Surgical "Hermanos Ameijeiras" Hospital (Havana City, Cuba) has served to demostrate that it is feasible not only to create a theoretical and practical body to satisfy the aforementioned goals, but, also, to export it to another institutions of the country, in view of the fact that minimal investments for adquiring the resources needed to deploy such Program, as well as for training and capacitation of medic and paramedic personel in the corresponding Recording & Documentation and Feeding & Nutrition Good Practices might result in short-term economical and medical care benefits.

  3. [Biological Function of The Small G Protein Rap].

    PubMed

    Li, Shan-Shan; Guo, Xiao-Xi; An, Shu; Yang, Yang; Liu, Ying; Xu, Tian-Rui

    2016-02-01

    Rap has different biological functions on intracellular signaling pathways, such as regulating cell polarity, cell proliferation, cell differentiation, cell adhesion and cell movement. Furthermore, at tissue and organ level, Rap controls the establishment of neural polarity, synaptic growth, synaptic plasticity, neuronal migration and so on. Rap belongs to Ras family which contains two subtypes, Rap1 and Rap2. By binding GTP or GDP Rap transform between active or inactive state, and plays an important role as a molecular switch. Moreover, in the signal pathway of tumor, Rap inhibits cell transformation induced by the oncogene Ras, therefore inhibits the proliferation, invasion and migration of certain cancer cells by interacting with its downstream target molecules. In this review, we summarized the biological functions of Rap and discussed It's significance in cancer therapy and drug treatment of neurological diseases.

  4. Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP.

    PubMed

    Li, Yanping; Dillon, Tara J; Takahashi, Maho; Earley, Keith T; Stork, Philip J S

    2016-10-07

    Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Two small G proteins, Ras and Rap1, have been proposed to mediate this activation, with either Ras or Rap1 acting in distinct cell types. Using Hek293 cells, we show that both Ras and Rap1 are required for cAMP signaling to ERKs. The roles of Ras and Rap1 were distinguished by their mechanism of activation, dependence on the cAMP-dependent protein kinase (PKA), and the magnitude and kinetics of their effects on ERKs. Ras was required for the early portion of ERK activation by cAMP and was activated independently of PKA. Ras activation required the Ras/Rap guanine nucleotide exchange factor (GEF) PDZ-GEF1. Importantly, this action of PDZ-GEF1 was disrupted by mutation within its putative cyclic nucleotide-binding domain within PDZ-GEF1. Compared with Ras, Rap1 activation of ERKs was of longer duration. Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G. This is the first report of a mechanism for the cooperative actions of Ras and Rap1 in cAMP activation of ERKs. One physiological role for the sustained activation of ERKs is the transcription and stabilization of a range of transcription factors, including c-FOS. We show that the induction of c-FOS by cAMP required both the early and sustained phases of ERK activation, requiring Ras and Rap1, as well as for each of the Raf isoforms, B-Raf and C-Raf.

  5. Formerly Utilized Sites Remedial Action Program environmental compliance assessment checklists

    SciTech Connect

    Levine, M.B.; Sigmon, C.F.

    1989-09-29

    The purpose of the Environmental Compliance Assessment Program is to assess the compliance of Formerly Utilized Site Remedial Action Program (FUSRAP) sites with applicable environmental regulations and Department of Energy (DOE) Orders. The mission is to identify, assess, and decontaminate sites utilized during the 1940s, 1950s, and 1960s to process and store uranium and thorium ores in support of the Manhattan Engineer District and the Atomic Energy Commission. To conduct the FUSRAP environmental compliance assessment, checklists were developed that outline audit procedures to determine the compliance status of the site. The checklists are divided in four groups to correspond to these regulatory areas: Hazardous Waste Management, PCB Management, Air Emissions, and Water Discharges.

  6. Feeling the beat: the meaning of rap music for ethnically diverse Midwestern college students--a phenomenological study.

    PubMed

    Iwamoto, Derek K; Creswell, John; Caldwell, Leon

    2007-01-01

    Despite its national and international appeal, rap is considered one of the most controversial of music genres. Given the political charge it generates, rap music has spawned research across the social and health sciences. The majority of the research has investigated its impact on African Americans. Further, the research has tended to focus on negative aspects of the music; there has been a dearth of in-depth qualitative studies that explore how rap impacts the listener. Our phenomenological study explores that impact on ethnically diverse college students. Results indicate a profound psychological and educational effect and the discussion goes on to highlight the potential and innovative ways rap music can be utilized with adolescents in fields such as education, risk reduction programs, and counseling psychology.

  7. Dialogic Teaching in an Online Environment: Book Raps

    ERIC Educational Resources Information Center

    Simpson, Alyson

    2010-01-01

    This paper examines a blended learning context known as book raps where children read and respond to literary texts. In this particular e-literacy environment, readers discuss their opinions of a book under the guidance of a moderator known as a rap coordinator who provides stimulus questions known as rap points. The paper demonstrates how…

  8. Structure, functional regulation and signaling properties of Rap2B

    PubMed Central

    QU, DEBAO; HUANG, HUI; DI, JIEHUI; GAO, KEYU; LU, ZHENG; ZHENG, JUNNIAN

    2016-01-01

    The Ras family small guanosine 5′-triphosphate (GTP)-binding protein Rap2B is is a member of the Ras oncogene family and a novel target of p53 that regulates the p53-mediated pro-survival function of cells. The Rap2B protein shares ~90% homology with Rap2A, and its sequence is 70% identical to other members of the Rap family such as RaplA and RaplB. As a result, Rap2B has been theorized to have similar signaling effectors to the GTPase-binding protein Rap, which mediates various biological functions, including the regulation of sterile 20/mitogen-activated proteins. Since its identification in the early 1990s, Rap2B has elicited a considerable interest. Numerous studies indicate that Rap2B exerts specific biological functions, including binding and stimulating phospholipase C-ε and interferon-γ. In addition, downregulation of Rap2B affects the growth of melanoma cells. The present review summarizes the possible effectors and biological functions of Rap2B. Increasing evidence clearly supports the association between Rap2B function and tumor development. Therefore, it is conceivable that anticancer drugs targeting Rap2B may be generated as novel therapies against cancer. PMID:27073477

  9. Cultural Studies and Rap: The Poetry of an Urban Lyricist

    ERIC Educational Resources Information Center

    Parmar, Priya

    2005-01-01

    In this article, the author explores the many other faces of rap that do not get the media exposure that they rightfully deserve. As this article attempts to reveal, rap music, as a form of cultural pedagogy and critical literacy, is only one way to achieve the goals of a "critical education." Rap lyrics can also be used as a tool to help the…

  10. Dissection of RAP-LRP interactions: binding of RAP and RAP fragments to complement-like repeats 7 and 8 from ligand binding cluster II of LRP.

    PubMed

    Lazic, Ana; Dolmer, Klavs; Strickland, Dudley K; Gettins, Peter G W

    2006-06-15

    The receptor associated protein (RAP) is a three domain 38kDa ER-resident chaperone that helps folding of LRP and other LDL receptor family members and prevents premature binding of protein ligands. It competes strongly with all known LRP ligands. To further understanding of the specificity of RAP-LRP interactions, the binding of RAP and RAP fragments to two domains (CR7-CR8) from one of the main ligand-binding regions of LRP has been examined by 2D HSQC NMR spectroscopy and isothermal titration calorimetry. We found that RAP contains two binding sites for CR7-CR8, with the higher affinity site (K(d) approximately 1microM) located in the C-terminal two-thirds and the weaker site (K(d) approximately 5microM) in the N-terminal third of RAP. Residues from both CR7 and CR8 are involved in binding at each RAP site. The presence of more than one binding site on RAP for CR domains from LRP, together with the previous demonstration by others that RAP can bind to CR5-CR6 with comparably low affinities suggest an explanation for the dual roles of RAP as a folding chaperone and a tight competitive inhibitor of ligand binding.

  11. Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach.

    PubMed Central

    Magnier, C; Corvazier, E; Aumont, M C; Le Jemtel, T H; Enouf, J

    1995-01-01

    Although the interrelationship between the two messengers Ca2+ and cyclic AMP in platelet function is well documented, its mechanism of action still remains to be established. We investigated here the question of the regulation of platelet Ca(2+)-ATPases by cyclic AMP through the phosphorylation of the Rap1 protein using a pathological model. We first found experimental conditions where Ca(2+)-transport by platelet membrane vesicles appeared to be dependent on the phosphorylation of the Rap1 protein. Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP-dependent protein kinase (C. Sub.). In the first patients studied, we found no significant modification in the expression of the 97 kDa Ca(2+)-ATPase by Western blotting using the PL/IM 430 monoclonal antibody which specifically recognized this isoform. In contrast, the Rap1 protein was differentially phosphorylated when using 15 micrograms/ml of the C. Sub. These results allowed us to use these pathological platelets to study the relationship between the expression of Rap1 protein and the regulation of Ca2+ transport by selecting a patient with severe heart failure. We could show a decrease in the expression as well as in the phosphorylation of Rap1 protein and demonstrate a lower effect of C. Sub. on Ca2+ transport. Finally, by studying a further series of patients, we could confirm that the decrease in Rap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of Rap1 protein with the stimulatory effect of C. Sub. on Ca2+ transport. Besides the evidence for regulation of the expression of the Rap1 protein in platelets from patients with heart failure, these findings constitute a new approach in favour of the regulation of platelet Ca2

  12. Federal government information handbook: formerly utilized sites remedial action program

    SciTech Connect

    Not Available

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations.

  13. RapA2 Is a Calcium-binding Lectin Composed of Two Highly Conserved Cadherin-like Domains That Specifically Recognize Rhizobium leguminosarum Acidic Exopolysaccharides*

    PubMed Central

    Abdian, Patricia L.; Caramelo, Julio J.; Ausmees, Nora; Zorreguieta, Angeles

    2013-01-01

    In silico analyses have revealed a conserved protein domain (CHDL) widely present in bacteria that has significant structural similarity to eukaryotic cadherins. A CHDL domain was shown to be present in RapA, a protein that is involved in autoaggregation of Rhizobium cells, biofilm formation, and adhesion to plant roots as shown by us and others. Structural similarity to cadherins suggested calcium-dependent oligomerization of CHDL domains as a mechanistic basis for RapA action. Here we show by circular dichroism spectroscopy, light scattering, isothermal titration calorimetry, and other methods that RapA2 from Rhizobium leguminosarum indeed exhibits a cadherin-like β-sheet conformation and that its proper folding and stability are dependent on the binding of one calcium ion per protein molecule. By further in silico analysis we also reveal that RapA2 consists of two CHDL domains and expand the range of CHDL-containing proteins in bacteria and archaea. However, light scattering assays at various concentrations of added calcium revealed that RapA2 formed neither homo-oligomers nor hetero-oligomers with RapB (a distinct CHDL protein), indicating that RapA2 does not mediate cellular interactions through a cadherin-like mechanism. Instead, we demonstrate that RapA2 interacts specifically with the acidic exopolysaccharides (EPSs) produced by R. leguminosarum in a calcium-dependent manner, sustaining a role of these proteins in the development of the biofilm matrix made of EPS. Because EPS binding by RapA2 can only be attributed to its two CHDL domains, we propose that RapA2 is a calcium-dependent lectin and that CHDL domains in various bacterial and archaeal proteins confer carbohydrate binding activity to these proteins. PMID:23235153

  14. Rapping the 27 Amendments to the Constitution

    ERIC Educational Resources Information Center

    Knaresborough, Adam

    2009-01-01

    Early in the year, the students of history and government at Mountain View High School in Stafford, Virginia, began to devise hand motions to help memorize the 27 amendments to the Constitution for government class. Three students in the school who are interested in hip hop music then suggested composing a rap song about the topic. Working with…

  15. The Rap on Hip-Hop

    ERIC Educational Resources Information Center

    Piekarski, Bill

    2004-01-01

    From its humble origins some 30 years ago in New York's bombed-out, poverty-ravaged South Bronx, hip-hop has risen to become a dominant cultural force both here and abroad. Strictly defined, the term refers to the entire cultural constellation that accompanies rap music, which in 2001 surpassed country music as the most popular musical genre in…

  16. Structural basis of response regulator dephosphorylation by Rap phosphatases.

    PubMed

    Parashar, Vijay; Mirouze, Nicolas; Dubnau, David A; Neiditch, Matthew B

    2011-02-08

    Bacterial Rap family proteins have been most extensively studied in Bacillus subtilis, where they regulate activities including sporulation, genetic competence, antibiotic expression, and the movement of the ICEBs1 transposon. One subset of Rap proteins consists of phosphatases that control B. subtilis and B. anthracis sporulation by dephosphorylating the response regulator Spo0F. The mechanistic basis of Rap phosphatase activity was unknown. Here we present the RapH-Spo0F X-ray crystal structure, which shows that Rap proteins consist of a 3-helix bundle and a tetratricopeptide repeat domain. Extensive biochemical and genetic functional studies reveal the importance of the observed RapH-Spo0F interactions, including the catalytic role of a glutamine in the RapH 3-helix bundle that inserts into the Spo0F active site. We show that in addition to dephosphorylating Spo0F, RapH can antagonize sporulation by sterically blocking phosphoryl transfer to and from Spo0F. Our structure-function analysis of the RapH-Spo0F interaction identified Rap protein residues critical for Spo0F phosphatase activity. This information enabled us to assign Spo0F phosphatase activity to a Rap protein based on sequence alone, which was not previously possible. Finally, as the ultimate test of our newfound understanding of the structural requirements for Rap phosphatase function, a non-phosphatase Rap protein that inhibits the binding of the response regulator ComA to DNA was rationally engineered to dephosphorylate Spo0F. In addition to revealing the mechanistic basis of response regulator dephosphorylation by Rap proteins, our studies support the previously proposed T-loop-Y allostery model of receiver domain regulation that restricts the aromatic "switch" residue to an internal position when the β4-α4 loop adopts an active-site proximal conformation.

  17. Structural Basis of Response Regulator Dephosphorylation by Rap Phosphatases

    SciTech Connect

    V Parashar; N Mirouze; D Dubnau; M Neiditch

    2011-12-31

    Bacterial Rap family proteins have been most extensively studied in Bacillus subtilis, where they regulate activities including sporulation, genetic competence, antibiotic expression, and the movement of the ICEBs1 transposon. One subset of Rap proteins consists of phosphatases that control B. subtilis and B. anthracis sporulation by dephosphorylating the response regulator Spo0F. The mechanistic basis of Rap phosphatase activity was unknown. Here we present the RapH-Spo0F X-ray crystal structure, which shows that Rap proteins consist of a 3-helix bundle and a tetratricopeptide repeat domain. Extensive biochemical and genetic functional studies reveal the importance of the observed RapH-Spo0F interactions, including the catalytic role of a glutamine in the RapH 3-helix bundle that inserts into the Spo0F active site. We show that in addition to dephosphorylating Spo0F, RapH can antagonize sporulation by sterically blocking phosphoryl transfer to and from Spo0F. Our structure-function analysis of the RapH-Spo0F interaction identified Rap protein residues critical for Spo0F phosphatase activity. This information enabled us to assign Spo0F phosphatase activity to a Rap protein based on sequence alone, which was not previously possible. Finally, as the ultimate test of our newfound understanding of the structural requirements for Rap phosphatase function, a non-phosphatase Rap protein that inhibits the binding of the response regulator ComA to DNA was rationally engineered to dephosphorylate Spo0F. In addition to revealing the mechanistic basis of response regulator dephosphorylation by Rap proteins, our studies support the previously proposed T-loop-Y allostery model of receiver domain regulation that restricts the aromatic 'switch' residue to an internal position when the {beta}4-{alpha}4 loop adopts an active-site proximal conformation.

  18. Guidelines for Affirmative Action Programs. Promoting Equal Opportunity in Higher Education [and] Authors' Addendum.

    ERIC Educational Resources Information Center

    Reklaitis, Robert F.; And Others

    This paper reviews critical court cases regarding affirmative action and offers guidelines to institutions of higher education evaluating and developing their affirmative action programs in the context of continuing changes in this aspect of law. It discusses the following aspects of affirmative action: what affirmative action is and the need for…

  19. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246,...

  20. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246,...

  1. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246,...

  2. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246,...

  3. 29 CFR 1608.5 - Affirmative action compliance programs under Executive Order No. 11246, as amended.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... EMPLOYMENT OPPORTUNITY COMMISSION AFFIRMATIVE ACTION APPROPRIATE UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, AS AMENDED § 1608.5 Affirmative action compliance programs under Executive Order No. 11246,...

  4. From Knowledge to Action: Tips for Encouraging and Measuring Program-Related Behavior Change

    ERIC Educational Resources Information Center

    Chazdon, Scott; Horntvedt, Jody; Templin, Elizabeth

    2016-01-01

    It is challenging to document the behavior changes that result from Extension programming. This article describes an evaluation method we call the "action items method." Unlike other approaches for measuring behavior change, this method requires program participants to define their own action plans as part of a program and then asks them…

  5. NASULGC Council on Extension, Committee on Program Innovation and Action Oriented Research; 1968 Report. Part 1. Program Innovations. Part 2. Action Oriented Research.

    ERIC Educational Resources Information Center

    National Association of State Universities and Land Grant Colleges, Washington, DC.

    This report on extension activities of member institutions of the National Association of State Universities and Land Grant Colleges describes 91 program innovations and action oriented research activities. Objectives, sponsorship, program evaluations, and other data are cited for program innovations in such areas as continuing medical education,…

  6. The 3D Elevation Program initiative: a call for action

    USGS Publications Warehouse

    Sugarbaker, Larry J.; Constance, Eric W.; Heidemann, Hans Karl; Jason, Allyson L.; Lukas, Vicki; Saghy, David L.; Stoker, Jason M.

    2014-01-01

    The 3D Elevation Program (3DEP) initiative is accelerating the rate of three-dimensional (3D) elevation data collection in response to a call for action to address a wide range of urgent needs nationwide. It began in 2012 with the recommendation to collect (1) high-quality light detection and ranging (lidar) data for the conterminous United States (CONUS), Hawaii, and the U.S. territories and (2) interferometric synthetic aperture radar (ifsar) data for Alaska. Specifications were created for collecting 3D elevation data, and the data management and delivery systems are being modernized. The National Elevation Dataset (NED) will be completely refreshed with new elevation data products and services. The call for action requires broad support from a large partnership community committed to the achievement of national 3D elevation data coverage. The initiative is being led by the U.S. Geological Survey (USGS) and includes many partners—Federal agencies and State, Tribal, and local governments—who will work together to build on existing programs to complete the national collection of 3D elevation data in 8 years. Private sector firms, under contract to the Government, will continue to collect the data and provide essential technology solutions for the Government to manage and deliver these data and services. The 3DEP governance structure includes (1) an executive forum established in May 2013 to have oversight functions and (2) a multiagency coordinating committee based upon the committee structure already in place under the National Digital Elevation Program (NDEP). The 3DEP initiative is based on the results of the National Enhanced Elevation Assessment (NEEA) that was funded by NDEP agencies and completed in 2011. The study, led by the USGS, identified more than 600 requirements for enhanced (3D) elevation data to address mission-critical information requirements of 34 Federal agencies, all 50 States, and a sample of private sector companies and Tribal and local

  7. Targeted disruption of N-RAP gene function by RNA interference: a role for N-RAP in myofibril organization.

    PubMed

    Dhume, Ashwini; Lu, Shajia; Horowits, Robert

    2006-08-01

    N-RAP is a muscle-specific protein concentrated in myofibril precursors during sarcomere assembly and at intercalated disks in adult heart. We used RNA interference to achieve a targeted decrease in N-RAP transcript and protein levels in primary cultures of embryonic mouse cardiomyocytes. N-RAP transcript levels were decreased by approximately 70% within 2 days following transfection with N-RAP specific siRNA. N-RAP protein levels steadily decreased over several days, reaching approximately 50% of control levels within 6 days. N-RAP protein knockdown was associated with decreased myofibril assembly, as assessed by alpha-actinin organization into mature striations. Transcripts encoding N-RAP binding proteins associated with assembling or mature myofibrils, such as alpha-actinin, Krp1, and muscle LIM protein, were expressed at normal levels during N-RAP protein knockdown, and alpha-actinin and Krp-1 protein levels were also unchanged. Transcripts encoding muscle myosin heavy chain and nonmuscle myosin heavy chain IIB were also expressed at relatively normal levels. However, decreased N-RAP protein levels were associated with dramatic changes in the encoded myosin proteins, with muscle myosin heavy chain levels increasing and nonmuscle myosin heavy chain IIB decreasing. N-RAP transcript and protein levels recovered to normal by days 6 and 7, respectively, and the changes in myofibril organization and myosin heavy chain isoform levels were reversed. Our data indicate that we can achieve transient N-RAP protein knockdown using the RNA interference technique and that alpha-actinin organization into myofibrils in cardiomyocytes is closely linked to N-RAP protein levels. Finally, N-RAP protein levels regulate the balance between nonmuscle myosin IIB and muscle myosin by post-trancriptional mechanisms.

  8. WSTF Propulsion and Pyrotechnics Corrective Action Test Program Status-2000

    NASA Technical Reports Server (NTRS)

    Saulsberry, R.; Ramirez, J.; Julien, H. L.; Hart, M.; Smith, W.; Bement, L.; Meagher, N. E.

    2000-01-01

    Extensive propulsion and pyrotechnic testing has been in progress at the NASA Johnson Space Center White Sands Test Facility (WSTF) since 1995. This started with the Mars Observer Propulsion and Pyrotechnics Corrective Action Test Program (MOCATP). The MOCATP has concluded, but extensive pyrovalve testing and research and development has continued at WSTF. The capability to accurately analyze and measure pyrovalve combustion product blow-by, evaluate propellant explosions initiated by blow-by, and characterize pyrovalve operation continues to be used and improved. This paper contains an overview of testing since MOCATP inception, but focuses on accomplishments since the status was last reported at the 35th Joint Propulsion Conference, June, 1999. This new activity includes evaluation of 3/8 inch Conax pyrovalves; development and testing of advanced pyrovalve technologies; investigation of nondestructive evaluation techniques to inspect pyrotechnically induced hydrazine explosions both through testing and modeling. Data from this collection of projects are now being formatted into a pyrovalve applications and testing handbook and consensus standard to benefit pyrovalve users and spacecraft designers. The handbook is briefly described here and in more detail in a separate paper. To increase project benefit, pyrovalve manufacturers are encouraged to provide additional valves for testing and consideration, and feedback is encouraged in all aspects of the pyrotechnic projects.

  9. Uranium Mill Tailings Remedial Action Program. Annual status report

    SciTech Connect

    Not Available

    1980-12-01

    The purpose, scope, history, requirements, and management organization of the UMTRA Program are summarized in the Introduction. The remainder of the report describes progress made during the past year (F 1980) and discusses future plants and activities. Early emphasis has been on the four highest-priority sites because of their proximity to population centers. These sites are: (1) Canonsburg, Pennsylvania; (2) Salt Lake City, Utah; (3) Durango, Colorado; and (4) Shiprock, New Mexico (Navajo Reservation). To date, twenty-five vicinity properties near the Canonsburg site and two such properties near the Salt Lake City site have been designated for remedial action. A research effort was undertaken at a major vicinity property, the Mountain States Supply Company in Salt Lake City, to study the effects of heating-and-ventilating-system modification on indoor radon-daughter concentrations. A cooperative agreement was executed between DOE and the Commonwealth of Pennsylvania. A similar agreement with the State of Utah is expected to be executed in early FY 1981. Further, it is expected that additional cooperative agreements will be negotiated during FY 1981 with the States of Colorado and Wyoming and the Navajo Nation. It is expected that the processing site at Canonsburg, PA (the Canonsburg Industrial Park) will be acquired during FY 1981. Draft Environmental Impact Statements for the four highest-priority sites will be completed during FY 1981.

  10. Fact Sheet on the History of the Resource Conservation and Recovery Act (RCRA) Corrective Action Program

    EPA Pesticide Factsheets

    This fact sheet provides an overview of the main events that have shaped the current RCRA Corrective Action Program. It also provides a brief history of the statutory authorities, regulations, and policy that form the framework for the program.

  11. Drug Abuse & Alcoholism Control Program

    DTIC Science & Technology

    1971-09-01

    therapeutic program within the halfway house qnd " RAP " center programs. j. Casual Supplier: One who furnishes illegally, wrongfully or improperly to another...34 RAP " Center. f. To meet as often as required, but once a month as a minium. S. ORGANIZATION. a. The AMIIC should be chaired by a senior combat arms...with health and welfare agencies and alcohol and drug prevention programs in the civilian community. b. Halfway House - RAP Center should: (1) Serve

  12. The "RAP" on Reading Comprehension

    ERIC Educational Resources Information Center

    Hagaman, Jessica L.; Luschen, Kati; Reid, Robert

    2010-01-01

    Reading problems are one of the most frequent reasons students are referred for special education services and the disparity between students with reading difficulties and those who read successfully appears to be increasing. As a result, there is now an emphasis on early intervention programs such as RTI. In many cases, early intervention in…

  13. Department Raps States on Testing

    ERIC Educational Resources Information Center

    Olson, Lynn

    2006-01-01

    The U.S. Department of Education has notified 10 states that it intends to withhold a portion of their state administrative funds under the Title I program for failing to comply fully with the testing provisions of the No Child Left Behind Act by the end of the 2005-06 school year. Those funds would instead be diverted directly to school…

  14. Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.

    PubMed

    Paganini, Simona; Guidetti, Gianni Francesco; Catricalà, Silvia; Trionfini, Piera; Panelli, Simona; Balduini, Cesare; Torti, Mauro

    2006-01-01

    The Rap family of small GTP-binding proteins is composed by four different members: Rap1A, Rap1B, Rap2A and Rap2B. In this work we report the identification and characterization of a fifth member of this family of small GTPases. This new protein is highly homologous to Rap2A and Rap2B, binds labeled GTP on nitrocellulose, and is recognized by a specific anti-Rap2 antibody, but not by an anti-Rap1 antibody. The protein has thus been named Rap2C. Binding of GTP to recombinant purified Rap2C was Mg(2+)-dependent. However, accurate comparison of the kinetics of nucleotide binding and release revealed that Rap2C bound GTP less efficiently and possessed slower rate of GDP release compared to the highly homologous Rap2B. Moreover, in the presence of Mg(2+), the relative affinity of Rap2C for GTP was only about twofold higher than that for GDP, while, under the same conditions, Rap2B was able to bind GTP with about sevenfold higher affinity than GDP. When expressed in eukaryotic cells, Rap2C localized at the plasma membrane, as dictated by the presence of a CAAX motif at the C-terminus. We found that Rap2C represented the predominant Rap2 protein expressed in circulating mononuclear leukocytes, but was not present in platelets. Importantly, Rap2C was found to be expressed in human megakaryocytes, suggesting that the protein may be down-regulated during platelets generation. This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets. This new protein may therefore contribute to the still poorly clarified cellular events regulated by this subfamily of GTP-binding proteins.

  15. Rap G protein signal in normal and disordered lymphohematopoiesis.

    PubMed

    Minato, Nagahiro

    2013-09-10

    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the development and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy.

  16. Rap G protein signal in normal and disordered lymphohematopoiesis

    SciTech Connect

    Minato, Nagahiro

    2013-09-10

    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the development and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy.

  17. Human Rap1 modulates TRF2 attraction to telomeric DNA

    PubMed Central

    Janoušková, Eliška; Nečasová, Ivona; Pavloušková, Jana; Zimmermann, Michal; Hluchý, Milan; Marini, Victoria; Nováková, Monika; Hofr, Ctirad

    2015-01-01

    More than two decades of genetic research have identified and assigned main biological functions of shelterin proteins that safeguard telomeres. However, a molecular mechanism of how each protein subunit contributes to the protecting function of the whole shelterin complex remains elusive. Human Repressor activator protein 1 (Rap1) forms a multifunctional complex with Telomeric Repeat binding Factor 2 (TRF2). Rap1–TRF2 complex is a critical part of shelterin as it suppresses homology-directed repair in Ku 70/80 heterodimer absence. To understand how Rap1 affects key functions of TRF2, we investigated full-length Rap1 binding to TRF2 and Rap1–TRF2 complex interactions with double-stranded DNA by quantitative biochemical approaches. We observed that Rap1 reduces the overall DNA duplex binding affinity of TRF2 but increases the selectivity of TRF2 to telomeric DNA. Additionally, we observed that Rap1 induces a partial release of TRF2 from DNA duplex. The improved TRF2 selectivity to telomeric DNA is caused by less pronounced electrostatic attractions between TRF2 and DNA in Rap1 presence. Thus, Rap1 prompts more accurate and selective TRF2 recognition of telomeric DNA and TRF2 localization on single/double-strand DNA junctions. These quantitative functional studies contribute to the understanding of the selective recognition of telomeric DNA by the whole shelterin complex. PMID:25675958

  18. Interactions between perception and action programming: evidence from visual extinction and optic ataxia.

    PubMed

    Kitadono, Keiko; Humphreys, Glyn W

    2007-10-01

    We report a series of 7 experiments examining the interaction between visual perception and action programming, contrasting 2 neuropsychological cases: a case of visual extinction and a case with extinction and optic ataxia. The patients had to make pointing responses to left and right locations, whilst identifying briefly presented shapes. Different patterns of performance emerged with the two cases. The patient with "pure" extinction (i.e., extinction without optic ataxia) showed dramatic effects of action programming on perceptual report. Programming an action to the ipsilesional side increased extinction (on 2-item trials) and tended to induce neglect (on 1-item trials); this was ameliorated when the action was programmed to the contralesional side. Separable effects of using the contralesional hand and pointing to the contralesional side were apparent. In contrast, the optic ataxic patient showed few effects of congruency between the visual stimulus and the action, but extinction when an action was programmed. This effect was particularly marked when actions had to be made to peripheral locations, suggesting that it reflected reduced resources to stimuli. These effects all occurred using stimulus exposures that were completed well before actions were effected. The data demonstrate interactions between action programming and visual perception. Programming an action to the affected side with the contralesional limb reduces "pure" extinction because attention is coupled to the end point of the action. However, in a patient with deficient visuo-motor coupling (optic ataxia), programming an action can increase a spatial deficit by recruiting resources away from perceptual processing. The implications for models of perception and action are discussed.

  19. 42 CFR 431.820 - Corrective action under the MEQC program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... program. The agency must— (a) Take action to correct any active or negative case action errors found in the sample cases; (b) Take administrative action to prevent or reduce the incidence of those errors; and (c) By September 15 each year, submit to CMS a report on its error rate analysis and a...

  20. Making Tracks 1.0: Action Researching an Active Transportation Education Program

    ERIC Educational Resources Information Center

    Robinson, Daniel; Foran, Andrew; Robinson, Ingrid

    2014-01-01

    This paper reports on the results of the first cycle of an action research project. The objective of this action research was to examine the implementation of a school-based active transportation education program (Making Tracks). A two-cycle action research design was employed in which elementary school students' (ages 7-9), middle school…

  1. The Data-to-Action Framework: A Rapid Program Improvement Process

    ERIC Educational Resources Information Center

    Zakocs, Ronda; Hill, Jessica A.; Brown, Pamela; Wheaton, Jocelyn; Freire, Kimberley E.

    2015-01-01

    Although health education programs may benefit from quality improvement methods, scant resources exist to help practitioners apply these methods for program improvement. The purpose of this article is to describe the Data-to-Action framework, a process that guides practitioners through rapid-feedback cycles in order to generate actionable data to…

  2. 36 CFR 72.17 - Preliminary Action Program-commitments to be included.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... support services necessary for the development and completion of the Recovery Action Program...-commitments to be included. 72.17 Section 72.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs §...

  3. 36 CFR 72.17 - Preliminary Action Program-commitments to be included.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... support services necessary for the development and completion of the Recovery Action Program...-commitments to be included. 72.17 Section 72.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs §...

  4. 36 CFR 72.17 - Preliminary Action Program-commitments to be included.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... support services necessary for the development and completion of the Recovery Action Program...-commitments to be included. 72.17 Section 72.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs §...

  5. 36 CFR 72.17 - Preliminary Action Program-commitments to be included.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... support services necessary for the development and completion of the Recovery Action Program...-commitments to be included. 72.17 Section 72.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs §...

  6. 36 CFR 72.17 - Preliminary Action Program-commitments to be included.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... support services necessary for the development and completion of the Recovery Action Program...-commitments to be included. 72.17 Section 72.17 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Local Recovery Action Programs §...

  7. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true General purpose and contents of affirmative action programs. 60-2.10 Section 60-2.10 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of...

  8. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Additional required elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of...

  9. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Additional required elements of affirmative action programs. 60-2.17 Section 60-2.17 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of...

  10. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true General purpose and contents of affirmative action programs. 60-2.10 Section 60-2.10 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of...

  11. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false General purpose and contents of affirmative action programs. 60-2.10 Section 60-2.10 Public Contracts and Property Management... EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of...

  12. Sketches of Local Action Programs for School Environmental Education 12/73 to 6/74.

    ERIC Educational Resources Information Center

    Project KARE, Blue Bell, PA.

    Twenty-two elementary and secondary schools from throughout the five-county Southeastern Pennsylvania region were selected by Project KARE (Knowledgeable Action to Restore our Environment) to receive grants for Local Action Programs (LAP) of environmental education during 1973-1974. This guide reviews these twenty-two programs including the…

  13. Building a Knowledge to Action Program in Stroke Rehabilitation.

    PubMed

    Janzen, Shannon; McIntyre, Amanda; Richardson, Marina; Britt, Eileen; Teasell, Robert

    2016-09-01

    The knowledge to action (KTA) process proposed by Graham et al (2006) is a framework to facilitate the development and application of research evidence into clinical practice. The KTA process consists of the knowledge creation cycle and the action cycle. The Evidence Based Review of Stroke Rehabilitation is a foundational part of the knowledge creation cycle and has helped guide the development of best practice recommendations in stroke. The Rehabilitation Knowledge to Action Project is an audit-feedback process for the clinical implementation of best practice guidelines, which follows the action cycle. The objective of this review was to: (1) contextualize the Evidence Based Review of Stroke Rehabilitation and Rehabilitation Knowledge to Action Project within the KTA model and (2) show how this process led to improved evidence-based practice in stroke rehabilitation. Through this process, a single centre was able to change clinical practice and promote a culture that supports the use of evidence-based practices in stroke rehabilitation.

  14. Movement observation specifies motor programs activated by the action observed objective.

    PubMed

    Lago, Angel; Fernandez-del-Olmo, Miguel

    2011-04-15

    There are human cortical areas that fire both when a person executes an action and when he observes someone performing a similar action. The observer activates a motor program that resembles the observed action. However, it is not known whether the motor program activated via action observation is muscle specific. In this study, using simple pulse transcranial magnetic stimulation (TMS) applied over the primary motor cortex (M1), we investigated whether the Mirror System activates a muscle specific motor program, or codes the observed action in terms of its goal. The results showed that when subjects observed a static effector in front of an object, cortical excitability was enhanced even in muscles not involved in the observed movement, but that are able to achieve the goal of the action. When there was an effector-object interaction the motor program activated via action observation is muscle specific. These results suggest that when subjects observe an object related action there is an activation of a motor program based on the observed action goal, that is transformed into a muscle specific program when the subject shows an effector-object interaction.

  15. Rap Music Literacy: A Case Study of Millennial Audience Reception to Rap Lyrics Depicting Independent Women

    ERIC Educational Resources Information Center

    Moody-Ramirez, Mia; Scott, Lakia M.

    2015-01-01

    Using a feminist lens and a constructivist approach as the theoretical framework, we used rap lyrics and videos to help college students explore mass media's representation of the "independent" Black woman and the concept of "independence" in general. Students must be able to formulate their own concept of independence to…

  16. Stages of Development in Poverty Program Neighborhood Action Committees

    ERIC Educational Resources Information Center

    Zurcher, Louis A., Jr.

    1969-01-01

    Two discussion papers, commenting on the main article, are included: (1) "Community Action: The Limits of a Developmental Framework by Martin Rein, and (2) "For the Advocate and the Innovator by Franklin M. Zweig.

  17. Interprofessional education in action: the VA Quality Scholars fellowship program.

    PubMed

    Patrician, Patricia A; Dolansky, Mary; Estrada, Carlos; Brennan, Caitlin; Miltner, Rebecca; Newsom, Jeremiah; Olds, Danielle; Splaine, Mark; Moore, Shirley

    2012-09-01

    Although there are many examples of interprofessional education activities that focus on quality and safety, few include longitudinal experiences of teams working together over time. One exception is the Veterans Affairs Quality Scholars (VAQS) fellowship program. This article describes the integration of interprofessional education into the VAQS fellowship program, offers 2 examples of interprofessional projects conducted by the fellows, and discusses the VAQS program as a model for others to consider in developing interprofessional training programs in safety and quality improvement.

  18. Listening to Rap: Cultures of Crime, Cultures of Resistance

    ERIC Educational Resources Information Center

    Tanner, Julian; Asbridge, Mark; Wortley, Scot

    2009-01-01

    This research compares representations of rap music with the self-reported criminal behavior and resistant attitudes of the music's core audience. Our database is a large sample of Toronto high school students (n = 3,393) from which we identify a group of listeners, whose combination of musical likes and dislikes distinguish them as rap univores.…

  19. Positive Use of Rap Music in the Classroom.

    ERIC Educational Resources Information Center

    Anderson, Edward

    As an extension of African-Americans' rich language and musical heritage and abilities, rap music has some value in the educational setting. Rap music started as a dance fad beginning in the mid-1970s among Blacks and Hispanics in New York's outer boroughs. It is another generational brand of Black language and musical usage and an extension of…

  20. Fiscal Year 2013 Trails Management Program Mitigation Action Plan Annual Report, October 2013

    SciTech Connect

    Pava, Daniel S.

    2015-03-25

    This Trails Management Program Mitigation Action Plan Annual Report (Trails MAPAR) has been prepared for the Department of Energy (DOE)/National Nuclear Security Administration (NNSA) as part of implementing the 2003 Final Environmental Assessment for the Proposed Los Alamos National Laboratory Trails Management Program (DOE 2003). The Trails Mitigation Action Plan (MAP) is now a part of the Site-Wide Environmental Impact Statement for the Continued Operation of Los Alamos National Laboratory (DOE/EIS 0380) Mitigation Action Plan (2008 SWEIS MAP) (DOE 2008). The MAP provides guidance for the continued implementation of the Trails Management Program at Los Alamos National Laboratory (LANL) and integration of future mitigation actions into the 2008 SWEIS MAP to decrease impacts associated with recreational trails use at LANL. This eighth MAPAR includes a summary of Trails Management Program activities and actions during Fiscal Year (FY) 2013, from October 2012 through September 2013.

  1. A Systematic Review on the Functions of Rap Among Gangs.

    PubMed

    Lozon, Jeffrey; Bensimon, Moshe

    2015-11-27

    Although the field of gangs is well studied, information regarding the way gangs may use or misuse music for different needs is sparse. The aim of this systematic review is to gather descriptive and empirical information to ascertain the important roles rap music possesses within gang life. This review suggests five main functions of rap used within gangs with an emphasis on the subgenre of gangsta rap. First, rap facilitates antisocial behavior by reinforcing such messages in its lyrics. Second, its deviant lyrics serve as a reflection of the violent reality experienced in many urban ghetto communities. Third, it operates as a means for constructing individual and collective identity, as well as resistance identity. Fourth, it functions as an educating force by teaching its members how to act and respond in the urban ghetto. Finally, rap glorifies gang norms among newcomers and successfully spreads its values to the general population.

  2. Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 12. Environmental Restoration Program

    SciTech Connect

    Not Available

    1991-09-01

    The 664 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions constitute the twelfth in a series of reports prepared annually for the US Department of Energy Remedial Action Programs. Citations to foreign and domestic literature of all types -- technical reports, progress reports, journal articles, symposia proceedings, theses, books, patents, legislation, and research project descriptions -- have been included. The bibliography contains scientific, technical, economic, regulatory, and legal information pertinent to the US Department of Energy Remedial Action Programs. Major sections are (1) Decontamination and Decommissioning Program, (2) Nuclear Facilities Decommissioning, (3) Formerly Utilized Sites Remedial Action Program, (4) Facilities Contaminated with Naturally Occurring Radionuclides, (5) Uranium Mill Tailings Remedial Action Program, (6) Uranium Mill Tailings Management, (7) Technical Measurements Center, and (8) Environmental Restoration Program. Within these categories, references are arranged alphabetically by first author. Those references having no individual author are listed by corporate affiliation or by publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word. This report is a product of the Remedial Action Program Information Center (RAPIC), which selects, analyzes, and disseminates information on environmental restoration and remedial actions. RAPIC staff and resources are available to meet a variety of information needs. Contact the center at FTS 624-7764 or (615) 574-7764.

  3. Mars Observer Propulsion and Pyrotechnics Corrective Actions Test Program Blanket Release

    NASA Technical Reports Server (NTRS)

    Saulsberry, Regor L.; Fries, Joseph (Technical Monitor)

    1999-01-01

    The Mars Observer Propulsion and Pyrotechnic Corrective Actions Test Program has been in progress at the NASA White Sands Test Facility since 1995. This program has developed capabilities to accurately characterize pyrovalve hazards and has established corrective actions that arc helping to preclude loss of spacecraft due to pyrovalve and propellant interaction. Rather than wait for conclusion of the test program, significant rest results, findings, and safety recommendations have been and will continue to be released soon after they became available to meet needs of near-term NASA and commercial space programs. This release will cover approximately three to five papers per year until program end.

  4. Using Action Research to Engage Youth in Improving OST Programming

    ERIC Educational Resources Information Center

    Hubbard, Brian

    2015-01-01

    Youth are often portrayed as apathetic, uninvolved, and reluctant to participate in their communities (Baizerman, Hildreth, & Roholt, 2013). Ironically, however, communities offer few opportunities for youth to address issues that are compelling to their interests and that engage their commitment and action (Bradford & Cullen, 2012;…

  5. [50 years ago: documentation concerning Bernburg's "euthanasia"-action program].

    PubMed

    Kaiser, W

    1990-07-15

    50 years ago within a so-called "euthanasia" action programme several killing institutions were founded, in which nearly 100,000 patients suffering from mental diseases were brought to death. At the instance of the Bernburg mental hospital the involvements of the political psychiatry and the murdering mechanism are described.

  6. Granite School District's Comprehensive Counseling and Guidance Program in Action.

    ERIC Educational Resources Information Center

    Petersen, Judy

    This paper discusses the development of the Utah Model for Comprehensive Counseling and Guidance, and specifically, its application in the Granite School Districts Guidance Program. This model adopted the National Occupational Information Coordinating Committee (NOICC) competencies as its desired program content, which focuses on student outcomes.…

  7. Attitudes and Actions: Teacher Preparation Programs in ESL and IEPs.

    ERIC Educational Resources Information Center

    Perkins, Samuel S.

    The role of participant attitudes in the effectiveness of two teacher education program types, English-as-a-Second-Language (ESL) and intensive English programs (IEPs), are discussed. Three factors are viewed as influencing participant attitudes: professional separation of ESL and IEP instruction as fields of study; physical separation of ESL and…

  8. Rap Music Genres and Deviant Behaviors in French-Canadian Adolescents

    ERIC Educational Resources Information Center

    Miranda, Dave; Claes, Michel

    2004-01-01

    This study investigated the links between the preference for 4 rap music genres (American rap, French rap, hip hop/soul, and gangsta/hardcore rap) and 5 types of deviant behaviors in adolescence (violence, theft, street gangs, mild drug use, and hard drug use). The effects of peers' deviancy, violent media, and importance given to lyrics were…

  9. Photometric redshift estimation based on data mining with PhotoRApToR

    NASA Astrophysics Data System (ADS)

    Cavuoti, S.; Brescia, M.; De Stefano, V.; Longo, G.

    2015-03-01

    Photometric redshifts (photo-z) are crucial to the scientific exploitation of modern panchromatic digital surveys. In this paper we present PhotoRApToR (Photometric Research Application To Redshift): a Java/C ++ based desktop application capable to solve non-linear regression and multi-variate classification problems, in particular specialized for photo-z estimation. It embeds a machine learning algorithm, namely a multi-layer neural network trained by the Quasi Newton learning rule, and special tools dedicated to pre- and post-processing data. PhotoRApToR has been successfully tested on several scientific cases. The application is available for free download from the DAME Program web site.

  10. UK: legal action on needle exchange programs in prisons dismissed.

    PubMed

    Valette, Delphine

    2005-08-01

    In April 2005, a judicial review application against the UK Home Secretary for his failure to introduce needle exchange programs in prisons in England and Wales was dismissed by a judge at the Royal Courts of Justice (Administrative Court Division).

  11. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action...

  12. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action...

  13. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action...

  14. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action...

  15. 36 CFR 72.43 - Fundable elements: Recovery Action Program grants.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Fundable elements: Recovery Action Program grants. 72.43 Section 72.43 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grants for Recovery Action...

  16. 78 FR 11903 - Acceptability of Corrective Action Programs for Fuel Cycle Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... COMMISSION Acceptability of Corrective Action Programs for Fuel Cycle Facilities AGENCY: Nuclear Regulatory... Fuel Cycle Facilities.'' The draft NUREG provides guidance to the NRC staff on how to determine whether a Corrective Action Plan (CAP) submitted by the licensee of a fuel cycle facility is...

  17. The structure and conformational switching of Rap1B.

    PubMed

    Noguchi, Hiroki; Ikegami, Takahisa; Nagadoi, Aritaka; Kamatari, Yuji O; Park, Sam-Yong; Tame, Jeremy R H; Unzai, Satoru

    2015-06-19

    Rap1B is a small GTPase involved in the regulation of numerous cellular processes including synaptic plasticity, one of the bases of memory. Like other members of the Ras family, the active GTP-bound form of Rap1B can bind to a large number of effector proteins and so transmit signals to downstream components of the signaling pathways. The structure of Rap1B bound only to a nucleotide has yet to be solved, but might help reveal an inactive conformation that can be stabilized by a small molecule drug. Unlike other Ras family proteins such as H-Ras and Rap2A, Rap1B crystallizes in an intermediate state when bound to a non-hydrolyzable GTP analog. Comparison with H-Ras and Rap2A reveals conservative mutations relative to Rap1B, distant from the bound nucleotide, which control how readily the protein may adopt the fully activated form in the presence of GTP. High resolution crystallographic structures of mutant proteins show how these changes may influence the hydrogen bonding patterns of the key switch residues.

  18. Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier

    PubMed Central

    DiStefano, Peter V.; Smrcka, Alan V.; Glading, Angela J.

    2016-01-01

    The phosphoinositide-specific phospholipase C, PLCε, is a unique signaling protein with known roles in regulating cardiac myocyte growth, astrocyte inflammatory signaling, and tumor formation. PLCε is also expressed in endothelial cells, however its role in endothelial regulation is not fully established. We show that endothelial cells of multiple origins, including human pulmonary artery (HPAEC), human umbilical vein (HUVEC), and immortalized brain microvascular (hCMEC/D3) endothelial cells, express PLCε. Knockdown of PLCε in arterial endothelial monolayers decreased the effectiveness of the endothelial barrier. Concomitantly, RhoA activity and stress fiber formation were increased. PLCε-deficient arterial endothelial cells also exhibited decreased Rap1-GTP levels, which could be restored by activation of the Rap1 GEF, Epac, to rescue the increase in monolayer leak. Reintroduction of PLCε rescued monolayer leak with both the CDC25 GEF domain and the lipase domain of PLCε required to fully activate Rap1 and to rescue endothelial barrier function. Finally, we demonstrate that the barrier promoting effects PLCε are dependent on Rap1 signaling through the Rap1 effector, KRIT1, which we have previously shown is vital for maintaining endothelial barrier stability. Thus we have described a novel role for PLCε PIP2 hydrolytic and Rap GEF activities in arterial endothelial cells, where PLCε-dependent activation of Rap1/KRIT1 signaling promotes endothelial barrier stability. PMID:27612188

  19. Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.

    PubMed

    DiStefano, Peter V; Smrcka, Alan V; Glading, Angela J

    2016-01-01

    The phosphoinositide-specific phospholipase C, PLCε, is a unique signaling protein with known roles in regulating cardiac myocyte growth, astrocyte inflammatory signaling, and tumor formation. PLCε is also expressed in endothelial cells, however its role in endothelial regulation is not fully established. We show that endothelial cells of multiple origins, including human pulmonary artery (HPAEC), human umbilical vein (HUVEC), and immortalized brain microvascular (hCMEC/D3) endothelial cells, express PLCε. Knockdown of PLCε in arterial endothelial monolayers decreased the effectiveness of the endothelial barrier. Concomitantly, RhoA activity and stress fiber formation were increased. PLCε-deficient arterial endothelial cells also exhibited decreased Rap1-GTP levels, which could be restored by activation of the Rap1 GEF, Epac, to rescue the increase in monolayer leak. Reintroduction of PLCε rescued monolayer leak with both the CDC25 GEF domain and the lipase domain of PLCε required to fully activate Rap1 and to rescue endothelial barrier function. Finally, we demonstrate that the barrier promoting effects PLCε are dependent on Rap1 signaling through the Rap1 effector, KRIT1, which we have previously shown is vital for maintaining endothelial barrier stability. Thus we have described a novel role for PLCε PIP2 hydrolytic and Rap GEF activities in arterial endothelial cells, where PLCε-dependent activation of Rap1/KRIT1 signaling promotes endothelial barrier stability.

  20. RAP30/74: a general initiation factor that binds to RNA polymerase II.

    PubMed Central

    Burton, Z F; Killeen, M; Sopta, M; Ortolan, L G; Greenblatt, J

    1988-01-01

    We have previously shown by affinity chromatography that RAP30 and RAP74 are the mammalian proteins that have the highest affinity for RNA polymerase II. Here we show that RAP30 binds to RAP74 and that the RAP30-RAP74 complex (RAP30/74) is required for accurate initiation by RNA polymerase II. RAP30/74 is required for accurate transcription from the following promoters: the adenovirus major late promoter, the long terminal repeat of human immunodeficiency virus, P2 of the human c-myc gene, the mouse beta maj-globin promoter (all of which have TATA boxes), and the mouse dihydrofolate reductase promoter (which lacks a TATA box). RAP30/74 is not required for initiation by RNA polymerase III at the adenovirus virus-associated RNA promoters. Therefore, RAP30/74 is a general initiation factor that binds to RNA polymerase II. Images PMID:3380090

  1. The Effects of Action and Violence in Television Programs on the Social Behavior and Imaginative Play of Preschool Children.

    ERIC Educational Resources Information Center

    Huston-Stein, Aletha; And Others

    The independent contributions of action and violence in television programs to children's attention and social behavior were investigated. Pairs of preschool children were assigned to one of four television conditions (1) high action-high violence, (2) high action-low violence, (3) low action-low violence, or (4) no television. Action was defined…

  2. Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

    PubMed Central

    Xiao, Li; Zhu, Xuejing; Yang, Shikun; Liu, Fuyou; Zhou, Zhiguang; Zhan, Ming; Xie, Ping; Zhang, Dongshan; Li, Jun; Song, Panai; Kanwar, Yashpal S.; Sun, Lin

    2014-01-01

    Rap1b ameliorates high glucose (HG)-induced mitochondrial dysfunction in tubular cells. However, its role and precise mechanism in diabetic nephropathy (DN) in vivo remain unclear. We hypothesize that Rap1 plays a protective role in tubular damage of DN by modulating primarily the mitochondria-derived oxidative stress. The role and precise mechanisms of Rap1b on mitochondrial dysfunction and of tubular cells in DN were examined in rats with streptozotocin (STZ)-induced diabetes that have Rap1b gene transfer using an ultrasound microbubble-mediated technique as well as in renal proximal epithelial tubular cell line (HK-2) exposed to HG ambiance. The results showed that Rap1b expression decreased significantly in tubules of renal biopsies from patients with DN. Overexpression of a constitutively active Rap1b G12V notably ameliorated renal tubular mitochondrial dysfunction, oxidative stress, and apoptosis in the kidneys of STZ-induced rats, which was accompanied with increased expression of transcription factor C/EBP-β and PGC-1α. Furthermore, Rap1b G12V also decreased phosphorylation of Drp-1, a key mitochondrial fission protein, while boosting the expression of genes related to mitochondrial biogenesis and antioxidants in HK-2 cells induced by HG. These effects were imitated by transfection with C/EBP-β or PGC-1α short interfering RNA. In addition, Rap1b could modulate C/EBP-β binding to the endogenous PGC-1α promoter and the interaction between PGC-1α and catalase or mitochondrial superoxide dismutase, indicating that Rap1b ameliorates tubular injury and slows the progression of DN by modulation of mitochondrial dysfunction via C/EBP-β–PGC-1α signaling. PMID:24353183

  3. Characterize RAP80, a Potential Tumor Suppressor Gene

    DTIC Science & Technology

    2008-04-01

    sites of DNA damage (21–23). One of them is Fanconi anemia complementation group D2 ( FANCD2 ). However, RAP80 foci still form normally after irradiation...in FANCD2 -deficient cells (fig. S7), suggesting that there may be other as-yet-unidentified ubiquitinated proteins that act RAP80WT RAP80D1...Horazdovsky for providing constructs encoding HSJ1A and Ubi-GST, respectively; and A. D’Andrea for providing FANCD2 -deficient and FANCD2 -reconstituted

  4. Bellingham Bay action program: Initial data summaries and problem identification

    SciTech Connect

    Decker, D.S.; Sonnerup, R.; Greene, J.J.

    1989-08-01

    The report provides a synthesis of information describing the geographic extent and severity of estuarine contamination in Bellingham Bay within Puget Sound in Washington State. Summaries of existing data are provided for chemical contamination of sediment and biota, microbial contamination, eutrophication and contaminant sources. Original, summarized, tabulated, and mapped data are presented. The objective of the report is to provide a mechanism for comprehensively evaluating pollution problems in the more urbanized embayments and for providing a basis for prioritizing corrective actions. A decision making framework is presented for evaluating and prioritizing both sub-areas within Bellingham Bay and specific contaminant sources.

  5. Rebellious Rhapsody: Metal, Rap, Community, and Individuation.

    PubMed

    Reddick, Brad H.; Beresin, Eugene V.

    2002-03-01

    Music can be a powerful force and tool in the life of an adolescent. It forms a social context and informs the adolescent about the adult world through the lens of artists' lives, language, and presence as models. Allegiance to a form of music is allegiance to those who make it, a way to friendship and kinship, and a road to personal identity through belonging. In their relationships formed through music, teens can create a sense of community that may be lacking in the life of family. The rebellious music of earlier generations has given rise to complex musical genres, rap and heavy metal, that are strong in defiance and controversial in their violent and sexual content. What do these musical affiliations tell us about certain segments of adolescent development and culture? The authors consider this question by exploring the form and content of the music while using it to illuminate psychodynamic and psychosocial aspects of adolescent development.

  6. Evaluating Alternative High Schools: Program Evaluation in Action

    ERIC Educational Resources Information Center

    Hinds, Drew Samuel Wayne

    2013-01-01

    Alternative high schools serve some of the most vulnerable students and their programs present a significant challenge to evaluate. Determining the impact of an alternative high school that serves mostly at-risk students presented a significant research problem. Few studies exist that dig deeper into the characteristics and strategies of…

  7. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for Management of Uranium Byproduct Materials Pursuant to Section 84 of the Atomic Energy Act of 1954, as...

  8. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for Management of Uranium Byproduct Materials Pursuant to Section 84 of the Atomic Energy Act of 1954, as...

  9. 40 CFR 192.33 - Corrective action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 192.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION PROGRAMS HEALTH AND ENVIRONMENTAL PROTECTION STANDARDS FOR URANIUM AND THORIUM MILL TAILINGS Standards for Management of Uranium Byproduct Materials Pursuant to Section 84 of the Atomic Energy Act of 1954, as...

  10. "Everybody Gotta Have a Dream": Rap-centered Aspirations among Young Black Males Involved in Rap Music Production - A Qualitative Study.

    PubMed

    Foster, B Brian

    Youth express diverse desires for their educational and occupational futures. Sometimes these aspirations are directed towards somewhat unconventional careers such as rapping and other types of involvement in rap music production. Although many studies have examined traditional educational and occupational aspirations, less is known about the factors that give rise to rap-centered aspirations and how individuals pursue them, particularly as they transition to early adulthood. Drawing on 54 semi- and unstructured interviews with 29 black young men involved in rap music production, I find that rap-centered aspirations are shaped by a range of factors, most notably feedback regarding one's rap skills, access to recording and production equipment, and the financial means to maintain involvement in rap music production while also ensuring personal and family economic stability. The young men in the study attached different meanings to their aspirations and sometimes recast their motivations for participating in rap music production in response to various social and economic factors.

  11. Implementing Experiential Action Learning in International Management Education: The Global Business Strategic (GLOBUSTRAT) Consulting Program

    ERIC Educational Resources Information Center

    Kamath, Shyam; Agrawal, Jagdish; Krickx, Guido

    2008-01-01

    This paper discusses the theoretical foundations and implementation challenges and outcomes of a unique "hands-on" global consulting program that is integrated into an international EMBA program for mid-career and senior American and European managers. It details the challenges for the integration of experiential action learning, double-loop…

  12. Using Work Action Analysis to Identify Web-Portal Requirements for a Professional Development Program

    ERIC Educational Resources Information Center

    Nickles, George

    2007-01-01

    This article describes using Work Action Analysis (WAA) as a method for identifying requirements for a web-based portal that supports a professional development program. WAA is a cognitive systems engineering method for modeling multi-agent systems to support design and evaluation. A WAA model of the professional development program of the…

  13. Affirmative Action Strategies and Professional Schools: Case Illustrations of Exemplary Programs.

    ERIC Educational Resources Information Center

    Twale, Darla J.; And Others

    Seven case illustrations of affirmative action (AFA) programs are presented. Increases in the numbers of women and minority students at professional schools have been reported, but disadvantaged populations still suffer underrepresentation. The literature indicates that effective AFA may be realized through: early identification programs and…

  14. How Young Children Learn to Program with Sensor, Action, and Logic Blocks

    ERIC Educational Resources Information Center

    Wyeth, Peta

    2008-01-01

    Electronic Blocks are a new programming environment designed specifically for children aged between 3 and 8 years. These physical, stackable blocks include sensor blocks, action blocks, and logic blocks. By connecting these blocks, children can program a wide variety of structures that interact with one another and the environment. Electronic…

  15. The Evaluation of an Early Childhood Teacher Preparation Program: An Action Research Project

    ERIC Educational Resources Information Center

    Ragno, Kerry Sullivan

    2013-01-01

    The purpose of this dissertation was to evaluate the effectiveness of an Early Childhood Development Associate of Applied Science (AAS) degree program at one community college as part of an ongoing action research project. Prior to this dissertation study, external and internal barriers prevented the associate degree program stakeholders from…

  16. Visuomotor priming of action preparation and motor programming is similar in visually guided and memory-guided actions.

    PubMed

    Seegelke, Christian; Güldenpenning, Iris; Dettling, Julian; Schack, Thomas

    2016-10-01

    The present study examined whether the planning and execution of a reach-to-grasp movement is susceptible to visuomotor priming, and whether the strength of the priming effect depends on the availability of visual feedback. Participants grasped a target object as quickly as possible with either a whole-hand grip or a precision grip upon hearing an auditory stimulus. Prior to the auditory cue, a prime stimulus was presented. The prime stimulus depicted an object that was either congruent, incongruent, or ambiguous with respect to the required grasp, or it showed no object at all. In addition, participants performed the grasping task in one of three vision conditions: participants' vision was either occluded during both the motor programming and online-control phase (no-vision), participants had vision only during the motor programming phase (partial-vision), or they had vision available throughout task performance (full-vision). Results revealed the presence of two discrete priming effects. First, we found a facilitative effect of congruent compared to incongruent prime-grip combinations that influenced reaction times and kinematic parameters. Second, we found that movements were initiated slower during the no prime compared to all other conditions. However, this effect did not affect movement kinematics. Importantly, the size of both effects was similar regardless of vision. Together, these results suggest that visuomotor priming effects exhibit a similar influence on memory-guided and visually guided actions, indicating the same underlying object representations for those actions, and thus further challenging the real-time view of motor programming. Furthermore, the two different priming effects suggest the presence of functionally distinct, yet related modules or processes related to action preparation and motor programming, and hint towards possible ventrodorsal interactions.

  17. Technology needs for environmental restoration remedial action. Environmental Restoration Program

    SciTech Connect

    Watson, J.S.

    1992-11-01

    This report summarizes the current view of the most important technology needs for the US Department of Energy (DOE) facilities operated by Martin Marietta Energy Systems, Inc. These facilities are the Oak Ridge National Laboratory, the Oak Ridge K-25 Site, the Oak Ridge Y-12 Plant, the Paducah Gaseous Diffusion Plant, and the Portsmouth Gaseous Diffusion Plant. The sources of information used in this assessment were a survey of selected representatives of the Environmental Restoration (ER) programs at each facility, results from a questionnaire distributed by Geotech CWM, Inc., for DOE, and associated discussions with individuals from each facility. This is not a final assessment, but a brief look at an ongoing assessment; the needs will change as the plans for restoration change and, it is hoped, as some technical problems are solved through successful development programs.

  18. Chaperone-mediated specificity in Ras and Rap signaling.

    PubMed

    Azoulay-Alfaguter, Inbar; Strazza, Marianne; Mor, Adam

    2015-01-01

    Ras and Rap proteins are closely related small guanosine triphosphatase (GTPases) that share similar effector-binding domains but operate in a very different signaling networks; Ras has a dominant role in cell proliferation, while Rap mediates cell adhesion. Ras and Rap proteins are regulated by several shared processes such as post-translational modification, phosphorylation, activation by guanine exchange factors and inhibition by GTPase-activating proteins. Sub-cellular localization and trafficking of these proteins to and from the plasma membrane are additional important regulatory features that impact small GTPases function. Despite its importance, the trafficking mechanisms of Ras and Rap proteins are not completely understood. Chaperone proteins play a critical role in trafficking of GTPases and will be the focus of the discussion in this work. We will review several aspects of chaperone biology focusing on specificity toward particular members of the small GTPase family. Understanding this specificity should provide key insights into drug development targeting individual small GTPases.

  19. Rap1 and integrin inside-out signaling.

    PubMed

    Katagiri, Koko; Kinashi, Tatsuo

    2012-01-01

    In leukocytes, integrins play important roles in adhesive interactions with endothelium, antigen-presenting cells, and effector functions such as cytotoxicity. This chapter describes methods to study Ras proximity 1 (Rap1), a signaling molecule that has been increasingly recognized as an important regulator of integrin-mediated cell adhesion in the immune system as well as hemostasis. Rap1 is activated by a wide variety of external stimuli including chemokines and antigens. Signaling via Rap1 transmits an inside-out signal to the integrins, thereby increasing adhesiveness to ligands such as immunoglobulin superfamily proteins as well as extracellular matrix proteins and plasma proteins. This process induces leukocyte cell adhesion to the endothelium and antigen-presenting cells. In addition to integrin regulation, activated Rap1 induces cell polarity of lymphocytes, which is coordinated with LFA-1 redistribution to the leading edge.

  20. Quality Assurance Program Plan for the radiological survey activities program --- Uranium Mill Tailings Remedial Action Project

    SciTech Connect

    Knott, R.R.; Little, C.A.

    1991-08-01

    The Pollutant Assessments Group (PAG) at the Grand Junction Office (GJO), Colorado, of Oak Ridge National Laboratory (ORNL) is responsible for surveying designated sites in the vicinity of 24 inactive mill sites involved in the Department of Energy's (DOE) Uranium Mill Tailings Remedial Action Project (UMTRAP). The purpose of these surveys is to provide a recommendation to DOE whether to include or exclude these sites from UMTRAP based on whether the on-site residual radioactive material (if any) originated from the former mill sites, and radiation levels on-site are in excess of appropriate Environmental Protection Agency (EPA) criteria. This report describes the Quality Assurance Plan (QAP) for the PAG in conducting all activities related to UMTRAP. All quality assurance provisions given by the DOE, DOE/UMTRA and ORNL organizations are integrated into this plan. Specifically, this report identifies the policies and procedures followed in accomplishing the PAG/UMTRA QA program, identifies those organizational units involved in the implementation of these procedures, and outlines the respective responsibilities of those groups. 11 refs., 6 figs., 3 tabs.

  1. PhotoRApToR: PHOTOmetric Research APplication TO Redshifts

    NASA Astrophysics Data System (ADS)

    Brescia, Massimo; Cavuoti, Stefano

    2014-08-01

    PhotoRApToR (PHOTOmetric Research APplication TO Redshifts) solves regression and classification problems and is specialized for photo-z estimation. PhotoRApToR offers data table manipulation capabilities and 2D and 3D graphics tools for data visualization; it also provides a statistical report for both classification and regression experiments. The code is written in Java; the machine learning model is in C++ to increase the core execution speed.

  2. Rap video vs. traditional video for teaching nutrition.

    PubMed

    Connelly, J O; Berryman, T; Tolley, E A

    1996-01-01

    This study compared the effectiveness of a rap video with a traditional video in providing nutrition information. Sixty pregnant African-American females (ages 14 through 18) were randomly assigned to view either a rap video or a traditional video about good nutrition. The data revealed no significant difference in scores between the two versions; both videos produced significant learning; and 17 and 18 year olds scored higher than 15 and 16 year olds.

  3. F-35 Lightning II Program Quality Assurance and Corrective Action Evaluation

    DTIC Science & Technology

    2015-03-11

    Lockheed Martin, Fort Worth, Texas, for conformity to the contractually required Aerospace Standard (AS)9100, “Quality Management Systems...September 30, 2013, to determine whether the actions taken were appropriate. Findings The F-35 Program generally conformed to requirements and...Office of Inspector General (OIG) conducted an evaluation of the F-35 Lightning II Program (F-35 Program) for conformity to the contractually required

  4. Program overview: Remedial actions at Oak Ridge National Laboratory

    SciTech Connect

    Bates, L.D.; Trabalka, J.R.

    1988-07-27

    Research on and development of civilian and defense uses of nuclear materials and technologies have occurred at Oak Ridge National Laboratory (ORNL) since its creation as part of the World War II Manhattan Project in 1943. A diverse legacy of contaminated inactive facilities, research areas, and waste management areas exists; many are candidates for remedial action. Most attention is focused on waste management sites which contain the bulk of ORNL's environmental contamination. A wide variety of liquid and solid wastes, primarily radioactive wastes or mixed wastes in which radioactivity was the principal hazardous constituent, have been disposed of on-site in the past 45 years. One potential approach to remedial problems at ORNL is to design primarily for control and decay in situ (during an institutional control period of 100 years or more) of intermediate-lived wastes such as /sup 3/H, /sup 90/Sr, and /sup 137/Cs. Passive measures designed to provide greater long-term confinement (for example, in situ vitrification) could be exercised at sites contaminated with TRU wastes or high concentrations of hazardous constitutes. This approach would (a) provide a period sufficiently long for evaluation of the effectiveness of environmental processes and passive remedial measures in controlling the migration of long-lived materials, (b) allow additional time needed for development of new technologies for more permanent site stabilization, and (c) reduce the need for immediate implementation of the more-expensive exhumation and disposal option.

  5. Ras and Rap signaling in synaptic plasticity and mental disorders.

    PubMed

    Stornetta, Ruth L; Zhu, J Julius

    2011-02-01

    The Ras family GTPases (Ras, Rap1, and Rap2) and their downstream mitogen-activated protein kinases (ERK, JNK, and p38MAPK) and PI3K signaling cascades control various physiological processes. In neuronal cells, recent studies have shown that these parallel cascades signal distinct forms of AMPA-sensitive glutamate receptor trafficking during experience-dependent synaptic plasticity and adaptive behavior. Interestingly, both hypo- and hyperactivation of Ras/ Rap signaling impair the capacity of synaptic plasticity, underscoring the importance of a "happy-medium" dynamic regulation of the signaling. Moreover, accumulating reports have linked various genetic defects that either up- or down-regulate Ras/Rap signaling with several mental disorders associated with learning disability (e.g., Alzheimer's disease, Angelman syndrome, autism, cardio-facio-cutaneous syndrome, Coffin-Lowry syndrome, Costello syndrome, Cowden and Bannayan-Riley-Ruvalcaba syndromes, fragile X syndrome, neurofibromatosis type 1, Noonan syndrome, schizophrenia, tuberous sclerosis, and X-linked mental retardation), highlighting the necessity of happy-medium dynamic regulation of Ras/Rap signaling in learning behavior. Thus, the recent advances in understanding of neuronal Ras/Rap signaling provide a useful guide for developing novel treatments for mental diseases.

  6. Radiological assistance program: Region I. Part I

    SciTech Connect

    Musolino, S.V.; Kuehner, A.V.; Hull, A.P.

    1985-07-15

    The purpose of the Radiological Assistance Program (RAP) is to make DOE resources available and provide emergency assistance to state and local agencies in order to control radiological hazards, protect the public health and safety, and minimize the loss of property. This plan is an integral part of a nationwide program of radiological assistance established by the US DOE, and is implemented on a regional basis. The Brookhaven Area Office (BHO) Radiological Assistance Program is applicable to DOE Region I, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia. The BHO RAP-1 has been developed to: (a) ensure the availability of an effective radiological assistance capability to ensure the protection of persons and property; (b) provide guidelines to RAP-1 Team personnel for the evaluation of radiological incidents and implementation of corrective actions; (c) maintain liaison with other DOE installations, Federal, State and local organizations which may become involved in radiological assistance operations in Region I; and (d) encourage development of a local capability to cope with radiological incidents.

  7. Rho family and Rap GTPase activation assays.

    PubMed

    Jennings, Richard T; Knaus, Ulla G

    2014-01-01

    The detection of Ras superfamily GTPase activity in innate immune cells is important when studying signaling events elicited by various ligands and cellular processes. The development of high-affinity probes detecting the activated, GTP-bound form of small GTPases has significantly enhanced our understanding of initiation and termination of GTPase-regulated signaling pathways. These probes are created by fusing a high-affinity GTPase-binding domain derived from a specific downstream effector protein to glutathione S-transferase (GST). Such domains bind preferentially to the GTP-bound form of the upstream Rho or Ras GTPase. Coupling these probes to beads enables extraction of the complex and subsequent quantification of the active GTP-binding protein by immunoblotting. Although effector domains that discriminate efficiently between GDP- and GTP-bound states and highly specific antibodies are not yet available for every small GTPase, analysis of certain members of the Rho and Ras GTPase family is now routinely performed. Here, we describe affinity-based pulldown assays for detection of Rho GTPase (Rac1/2, Cdc42, RhoA/B) and Rap1/2 activity in stimulated neutrophils or macrophages.

  8. Uranium Mill Tailings Remedial Action Project Safety Advancement Field Effort (SAFE) Program

    SciTech Connect

    Not Available

    1994-02-01

    In 1992, the Uranium Mill Tailings Remedial Action (UMTRA) Project experienced several health and safety related incidents at active remediation project sites. As a result, the U.S. Department of Energy (DOE) directed the Technical Assistance Contractor (TAC) to establish a program increasing the DOE`s overall presence at operational remediation sites to identify and minimize risks in operations to the fullest extent possible (Attachments A and B). In response, the TAC, in cooperation with the DOE and the Remedial Action Contractor (RAC), developed the Safety Advancement Field Effort (SAFE) Program.

  9. RAP-011 augments callus formation in closed fractures in rats.

    PubMed

    Morse, Alyson; Cheng, Tegan L; Peacock, Lauren; Mikulec, Kathy; Little, David G; Schindeler, Aaron

    2016-02-01

    ACE-011 is a bone anabolic agent generated by fusing the extracellular domain of the Activin Type 2A receptor (ActRIIA) to an IgG-Fc. The orthopedic utility of ACE-011 was investigated using a murine analogue, RAP-011. Initially, a rat closed fracture model was tested using bi-weekly (biw) 10 mg/kg RAP-011. RAP-011 significantly increased callus length and callus bone volume (BV, +43% at 6w, p < 0.01). The polar moment of inertia was calculated to be substantively increased (+80%, p < 0.01), however mechanical bending tests showed a more modest increase in maximum load to failure (+24%, p < 0.05). Histology indicated enhanced appositional bone growth, but it was hypothesized that reduced remodeling, evidenced by decreased serum CTX (-16% at 6w, p < 0.01), could be compromising bone quality in the callus. A second closed fracture study was performed to examine lower "pulse" [RAP-011(p)] and "sustained" [RAP-011(s)] regimens of biw 0.6mg/kg × 2, 0.35mg/kg × 3 and 0.18mg/kg × 2, 0.1mg/kg × 7 respectively, compared with PTH(1-34) (25 μg/kg/d) and vehicle controls. RAP-011 treatments gave modest increases in callus length and callus BV at 6w (p < 0.01), but did not achieve an increase in maximum load over vehicle. In summary, RAP-011 is effective in promoting bone formation during repair, but optimizing callus bone quality will require further investigation.

  10. RapGAP9 regulation of the morphogenesis and development in Dictyostelium.

    PubMed

    Mun, Hyemin; Lee, Mi-Rae; Jeon, Taeck J

    2014-04-04

    Recent reports have demonstrated that the importance of Rap1-specific GTPase-activating proteins (GAPs) in the spatial and temporal regulation of Rap1 activity during cell migration and development in Dictyostelium. Here, we identified another putative Rap1 GAP-domain containing protein, showing high sequence homologies with those of human Rap1GAP and Dictyotelium RapGAP3, by bioinformatic search. Loss of RapGAP9 resulted in some defects in morphogenesis and development in Dicytostelium. rapGAP9 null cells were more flattened and spread, and highly multinucleated. Compared to wild-type cells, cells lacking RapGAP9 exhibited increased levels of F-actin and more filopodia. These results suggest that RapGAP9 is involved in the regulation of cytoskeleton reorganization and cytokinesis. rapGAP9 null cells showed a small increase of cell-substratum attachment and slightly lower moving speed and directionality compared to wild-type cells. In addition, the loss of RapGAP9 resulted in an altered morphology of fruiting body with a shorter length of stalk and spore. Identification and characterization of RapGAP9 in this study will provide further insights into the molecular mechanism by which Rap1 regulates cytoskeleton reorganization and morphogenesis in Dictyostelium.

  11. Enhanced cartilage regeneration in MIA/CD-RAP deficient mice.

    PubMed

    Schmid, R; Schiffner, S; Opolka, A; Grässel, S; Schubert, T; Moser, M; Bosserhoff, A-K

    2010-11-11

    Melanoma inhibitory activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) is a small soluble protein secreted from chondrocytes. It was identified as the prototype of a family of extracellular proteins adopting an SH3 domain-like fold. In order to study the consequences of MIA/CD-RAP deficiency in detail we used mice with a targeted gene disruption of MIA/CD-RAP (MIA-/-) and analyzed cartilage organisation and differentiation in in vivo and in vitro models. Cartilage formation and regeneration was determined in models for osteoarthritis and fracture healing in vivo, in addition to in vitro studies using mesenchymal stem cells of MIA-/- mice. Interestingly, our data suggest enhanced chondrocytic regeneration in the MIA-/- mice, modulated by enhanced proliferation and delayed differentiation. Expression analysis of cartilage tissue derived from MIA-/- mice revealed strong downregulation of nuclear RNA-binding protein 54-kDa (p54(nrb)), a recently described modulator of Sox9 activity. In this study, we present p54(nrb) as a mediator of MIA/CD-RAP to promote chondrogenesis. Taken together, our data indicate that MIA/CD-RAP is required for differentiation in cartilage potentially by regulating signaling processes during differentiation.

  12. Remote Area Power Supply (RAPS) load and resource profiles.

    SciTech Connect

    Giles, Lauren; Skolnik, Edward G.; Marchionini, Brian; Fall, Ndeye K.

    2007-07-01

    In 1997, an international team interested in the development of Remote Area Power Supply (RAPS) systems for rural electrification projects around the world was organized by the International Lead Zinc Research Organization (ILZRO) with the support of Sandia National Laboratories (SNL). The team focused on defining load and resource profiles for RAPS systems. They identified single family homes, small communities, and villages as candidates for RAPS applications, and defined several different size/power requirements for each. Based on renewable energy and resource data, the team devised a ''strawman'' series of load profiles. A RAPS system typically consists of a renewable and/or conventional generator, power conversion equipment, and a battery. The purpose of this report is to present data and information on insolation levels and load requirements for ''typical'' homes, small communities, and larger villages around the world in order to facilitate the development of robust design practices for RAPS systems, and especially for the storage battery component. These systems could have significant impact on areas of the world that would otherwise not be served by conventional electrical grids.

  13. Doing Poverty: Learning Outcomes among Students Participating in the Community Action Poverty Simulation Program

    ERIC Educational Resources Information Center

    Steck, Laura West; Engler, Jennifer N.; Ligon, Mary; Druen, Perri B.; Cosgrove, Erin

    2011-01-01

    This article discusses an application of the Lewinian/Kolb experiential learning model in the context of undergraduate participation in the Missouri Community Action Poverty Simulation (CAPS) program. CAPS is designed to simulate common, everyday experiences among people living in poverty as participants take on the roles of family members working…

  14. THE ROLE OF THE COMMUNITY ACTION PROGRAM IN THE SOLUTION OF RURAL YOUTH MANPOWER PROBLEMS.

    ERIC Educational Resources Information Center

    WILLIAMS, J. EARL

    SUBSTANTIAL POVERTY IN RURAL AREAS HAS BEEN CAUSED BY UNEMPLOYMENT DUE TO THE TECHNOLOGICAL REVOLUTION WHICH HAS MECHANIZED AGRICULTURAL OCCUPATIONS WHICH HAVE BEEN THE EXCLUSIVE DOMAIN OF THE FARM LABORER. A WELL-ORGANIZED COMMUNITY ACTION PROGRAM PROVIDES A MEANS OF EFFECTIVELY COMBATING THE RATE OF UNEMPLOYMENT WHICH IS ESPECIALLY HIGH AMONG…

  15. The DiabetAction Program: Implementation in Community-Based Settings

    ERIC Educational Resources Information Center

    Mathieu, Marie-Eve; Brochu, Martin; Beliveau, Louise

    2009-01-01

    Developed for specialists who want to increase the physical activity (PA) level of type 2 diabetic and at-risk individuals, the 10-week DiabetAction program introduced participants to a wide variety of cardiovascular, resistance, balance, and flexibility exercises. Thirty-three of 48 individuals completed the intervention in community-based…

  16. Action Research as an Approach to Integrating Sustainability into MBA Programs: An Exploratory Study

    ERIC Educational Resources Information Center

    Benn, Suzanne; Dunphy, Dexter

    2009-01-01

    This article reports on an exploratory project that employed an action research approach to integrating sustainability into core subjects in the MBA program at an Australian university. It documents the change methodology used, the theoretical basis for this choice, and the project outcomes. It then identifies some key enabling factors and…

  17. THE ROLE OF GUIDANCE SERVICES IN COMMUNITY ACTION PROGRAMS COMBATING POVERTY.

    ERIC Educational Resources Information Center

    GUIDANCE OBJECTIVES TO BE INCLUDED IN A COMMUNITY ACTION PROGRAM COMBATING PROVERTY ARE PRESENTED. THE OBJECTIVES INCLUDE EARLY ADJUSTMENT OF STUDENTS, EARLY IDENTIFICATION AND INTERPRETATION OF ABILITIES, EDUCATIONAL AND CAREER PLANS BASED ON ABILITIES AND SKILLS, PARENT UNDERSTANDING OF OPPORTUNITIES, ENCOURAGEMENT OF REALISTIC GOALS IN LINE…

  18. Kanbay's Global Leadership Development Program: A Case Study of Virtual Action Learning

    ERIC Educational Resources Information Center

    Marsh, Catherine; Johnson, Carrie

    2005-01-01

    This study examines action learning as a vehicle for the transfer of organizational values in a multi-cultural, virtual-team based leadership development process. A Case Study of Kanbay International's Global Leadership Development Program is used as a lens through which HRD researchers and practitioners may glimpse new possibilities for the…

  19. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-16

    ... Concrete and Steel Bridges AGENCY: Advisory Council on Historic Preservation. ACTION: Program Comment issued for streamlining Section 106 review for undertakings affecting post-1945 concrete and steel... consider the effects of undertakings on common bridges and culverts constructed of concrete or steel...

  20. 41 CFR 60-2.10 - General purpose and contents of affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... number of quantitative analyses designed to evaluate the composition of the workforce of the contractor... affirmative action program must include the following quantitative analyses: (i) Organizational profile—§ 60-2.11; (ii) Job group analysis—§ 60-2.12; (iii) Placement of incumbents in job groups—§ 60-2.13;...

  1. 38 CFR 62.60 - Program or budget changes and corrective action plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... submit to VA for approval a Corrective Action Plan (CAP) if, on a quarterly basis, actual supportive... supportive services grant activities vary from the grantee's program description provided in the supportive services grant agreement. (1) The CAP must identify the expenditure or activity source that has caused...

  2. 38 CFR 62.60 - Program or budget changes and corrective action plans.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... submit to VA for approval a Corrective Action Plan (CAP) if, on a quarterly basis, actual supportive... supportive services grant activities vary from the grantee's program description provided in the supportive services grant agreement. (1) The CAP must identify the expenditure or activity source that has caused...

  3. 38 CFR 62.60 - Program or budget changes and corrective action plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... submit to VA for approval a Corrective Action Plan (CAP) if, on a quarterly basis, actual supportive... supportive services grant activities vary from the grantee's program description provided in the supportive services grant agreement. (1) The CAP must identify the expenditure or activity source that has caused...

  4. Place-Based Learning: Action Learning in MA Program for Educational Practitioners

    ERIC Educational Resources Information Center

    Glassner, Amnon; Eran-Zoran, Yael

    2016-01-01

    The study presents a new pedagogical idea and practice for educational practitioners. The practice was developed as a workshop of MA program in order to change and expand the meaning of education for the wellbeing of the community. The "place-based learning" workshop combined action learning (AL) with project-based learning (PBL). The…

  5. Preventing Boys' Problems in Schools through Psychoeducational Programming: A Call to Action

    ERIC Educational Resources Information Center

    O'Neil, James M.; Lujan, Melissa L.

    2009-01-01

    Controversy currently exists on whether boys are in crises and, if so, what to do about it. Research is reviewed that indicates that boys have problems that affect their emotional and interpersonal functioning. Psychoeducational and preventive programs for boys are recommended as a call to action in schools. Thematic areas for boys' programming…

  6. A Structuration Theory Analysis of the Refugee Action Support Program in Greater Western Sydney

    ERIC Educational Resources Information Center

    Naidoo, Loshini

    2009-01-01

    This article uses Gidden's structuration theory to analyse the Refugee Action Support program in Greater Western Sydney. The study shows that many refugee students in Australian high schools experience difficulty with academic transition in mainstream classrooms due to their previous experiences in war-torn countries. As a result of the trauma…

  7. The Transformative Power of Youth Action Coalition's Multimodal Arts-for-Change Programming

    ERIC Educational Resources Information Center

    Turner, K. C. Nat; Way, Kate; Gray, Robin R. R.

    2013-01-01

    This article analyzes the potential of a series of Youth Action Coalition's (YAC) Arts-for-Change (AfC) youth programs for literacy and identity development, as well as for engaging youth in addressing issues of social justice. Drawing primarily on transcripts of interviews, surveys, and participant-observation fieldnotes inventorying changes in…

  8. Motivations and possible actions of potential criminal adversaries of US nuclear programs

    SciTech Connect

    Bass, G.; Jenkins, B.; Kellen, K.; Krofcheek, J.; Petty, G.; Reinstedt, R.; Ronfeldt, D.

    1981-01-01

    The motivations that might impel individuals or groups to undertake criminal actions against US nuclear facilities or programs are explored in the report (R and R-2554-SL) from which this note is taken. The analysis involves examination of the motivations behind nuclear-related crimes that have already occurred and of those behind analogous nonnuclear crimes.

  9. Using Action Research To Inform Curriculum Deliberation in an Early Childhood Education Teacher Education Program.

    ERIC Educational Resources Information Center

    Connolly, Mary; Dotson, Margaret

    An action research project was conducted at Ohio's Sinclair Community College to review and revise the early childhood teacher education curriculum. First, a modified Developing a Curriculum (DACUM) process was undertaken. Over 800 tasks from 8 validated task lists obtained from early childhood education (ECE) programs at other community colleges…

  10. Using Participatory Action Research To Evaluate Programs Serving People with Severe Disabilities: Reflections from the Field.

    ERIC Educational Resources Information Center

    Stevens, Karen A.; Folchman, Ruth

    1998-01-01

    This article discusses challenges in using participatory action research (PAR) in the evaluation of programs that provide services and supports to people with severe disabilities. Challenges include the need for modification of the model, time constraints, issues around power and position, and inclusion of individuals with severe disabilities.…

  11. Promoting the Development of Moral Identity, Behavior, and Commitment in a Social Action Program

    ERIC Educational Resources Information Center

    Jones, Jeffrey N.; Warnaar, Bethany L.; Bench, Joshua H.; Stroup, John

    2014-01-01

    Involvement in social action and community service can promote the construction of prosocial identities and enduring patterns of civic behavior. This article explores this important process for youth that participate in the PeaceJam Ambassadors program. High school-aged "PeaceJammers" study the lives of Nobel Peace laureates while…

  12. ACTION Live: Using Process Evaluation to Describe Implementation of a Worksite Wellness Program

    PubMed Central

    Johnson, Carolyn C.; Lai, Yen-Ling; Rice, Janet; Rose, Diego; Webber, Larry S.

    2010-01-01

    Objective Process evaluation is a necessary component of randomized controlled field trials. This is a descriptive paper that reviews process evaluation for the ACTION Wellness Program for Elementary School Personnel. Methods Methods included self-report by participants, documentation by program staff, and school administrator report. Variables evaluated were program dose, fidelity and reach, exposure to materials and activities, and school factors that could influence program implementation and/or outcomes. Results Dose and exposure were high across intervention schools and intervention years. Reach was variable across schools and activities. Schools on the East Bank of the Mississippi River generally had slightly better reach than schools on the West Bank. Some nutrition activities had higher levels of participation than physical activities. Conclusions High program dose reflected good effort and cooperation by program staff and schools. A disconnect between exposure and reach showed that high exposure did not always translate to high participation. PMID:20061882

  13. Source localization using recursively applied and projected (RAP) MUSIC

    SciTech Connect

    Mosher, J.C.; Leahy, R.M.

    1998-03-01

    A new method for source localization is described that is based on a modification of the well known multiple signal classification (MUSIC) algorithm. In classical MUSIC, the array manifold vector is projected onto an estimate of the signal subspace, but errors in the estimate can make location of multiple sources difficult. Recursively applied and projected (RAP) MUSIC uses each successively located source to form an intermediate array gain matrix, and projects both the array manifold and the signal subspace estimate into its orthogonal complement. The MUSIC projection is then performed in this reduced subspace. Using the metric of principal angles, the authors describe a general form of the RAP-MUSIC algorithm for the case of diversely polarized sources. Through a uniform linear array simulation, the authors demonstrate the improved Monte Carlo performance of RAP-MUSIC relative to MUSIC and two other sequential subspace methods, S and IES-MUSIC.

  14. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  15. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  16. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  17. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  18. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  19. Expression and alternative splicing of N-RAP during mouse skeletal muscle development.

    PubMed

    Lu, Shajia; Borst, Diane E; Horowits, Robert

    2008-12-01

    N-RAP alternative splicing and protein localization were studied in developing skeletal muscle tissue from pre- and postnatal mice and in fusing primary myotubes in culture. Messages encoding N-RAP-s and N-RAP-c, the predominant isoforms of N-RAP detected in adult skeletal muscle and heart, respectively, were present in a 5:1 ratio in skeletal muscle isolated from E16.5 embryos. N-RAP-s mRNA levels increased three-fold over the first 3 weeks of postnatal development, while N-RAP-c mRNA levels remained low. N-RAP alternative splicing during myotube differentiation in culture was similar to the pattern observed in embryonic and neonatal muscle, with N-RAP-s expression increasing and N-RAP-c mRNA levels remaining low. In both developing skeletal muscle and cultured myotubes, N-RAP protein was primarily associated with developing myofibrillar structures containing alpha-actinin, but was not present in mature myofibrils. The results establish that N-RAP-s is the predominant spliced form of N-RAP present throughout skeletal muscle development.

  20. "Fear of a Black Planet": Rap Music and Black Cultural Politics in the 1990s.

    ERIC Educational Resources Information Center

    Rose, Tricia

    1991-01-01

    Explores the exercise of institutional and ideological power over rap music and fans, how artists and fans respond to that context, and the complex relationships between rap's political economy and the sociologically based crime discourse that frames it. Rap's poetic voice is a political expression of the Black experience. (JB)

  1. Rap and Race: It's Got a Nice Beat, but What about the Message?

    ERIC Educational Resources Information Center

    Sullivan, Rachel E.

    2003-01-01

    Examined racial differences in black and white adolescents' preferences for and interpretations of rap music. Surveys of midwestern U.S. adolescents highlighted limited racial differences in the popularity of rap music. African American youth were more committed to rap and more likely to see it as life affirming. Though both groups had favorable…

  2. Small Business: Action Needed to Determine Whether DOD’s Comprehensive Subcontracting Plan Test Program Should Be Made Permanent

    DTIC Science & Technology

    2015-11-01

    SMALL BUSINESS Action Needed to Determine Whether DOD’s Comprehensive Subcontracting Plan Test Program Should Be...Subcontracting Plan Test Program Should Be Made Permanent 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...committees November 2015 SMALL BUSINESS Action Needed to Determine Whether DOD’s Comprehensive Subcontracting Plan Test Program Should Be Made

  3. New Jersey state information handbook: Formerly Utilized Sites Remedial Action Program

    SciTech Connect

    1980-10-31

    Under the implied authority of the Atomic Energy Act of 1954, as amended, radiological surveys and research work has been conducted to determine radiological conditions at former MED/AEC sites. As of this time, 31 sites in 13 states have been identified that require or may require remedial action. This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of New Jersey. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations. The loose-leaf format used in these volumes will allow the material to be updated periodically as the Remedial Action Program progresses.

  4. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    SciTech Connect

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  5. 'Ready. Set. ACTION!' A theater-based obesity prevention program for children: a feasibility study.

    PubMed

    Neumark-Sztainer, Dianne; Haines, Jess; Robinson-O'Brien, Ramona; Hannan, Peter J; Robins, Michael; Morris, Bonnie; Petrich, Christine A

    2009-06-01

    This study examined the feasibility of implementing an innovative theater-based after-school program, 'Ready. Set. ACTION!', to reach ethnically diverse and low-income children and their parents with obesity prevention messages. The study population included 96 children and 61 parents. Children were in fourth to sixth grade and 41% were overweight at baseline. Program impact was evaluated with a pre/post-randomized controlled study design, but a major focus was placed on the process evaluation conducted in the intervention schools. Intervention children and parents reported high program satisfaction and that they had made changes or intended to make positive changes in their behaviors due to program participation. However, few meaningful differences between the intervention and control conditions were found at follow-up. Thus, the combined process and impact evaluation results suggest that the intervention was effective in leading to increased awareness of the need for behavioral change, but was not powerful enough on its own to lead to behavioral change. From this feasibility study, we concluded that Ready. Set. ACTION! offers promise as a creative intervention strategy. The next research step may be to incorporate theater-based programs into more comprehensive school-based interventions, with both educational and environmental components, and evaluate program impact.

  6. RAP-1a is the main rhoptry-associated-protein-1 (RAP-1) recognized during infection with Babesia sp. BQ1 (Lintan) (B. motasi-like phylogenetic group), a pathogen of sheep in China.

    PubMed

    Niu, Qingli; Bonsergent, Claire; Rogniaux, Hélène; Guan, Guiquan; Malandrin, Laurence; Moreau, Emmanuelle

    2016-12-15

    Babesia sp. BQ1 (Lintan) is one of the parasites isolated from infected sheep in China that belongs to the B. motasi-like phylogenetic group. The rhoptry-associated-protein 1 (rap-1) locus in this group consists of a complex organization of 12 genes of three main types: 6 rap-1a variants intercalated with 5 identical copies of rap-1b and a single 3' ending rap-1c gene. In the present study, transcription analysis performed by standard RT-PCR demonstrated that the three different rap-1 gene types and the four rap-1a variants were transcribed by the parasite cultivated in vitro. Peptides, specific for each rap-1 type gene, were selected in putative linear B-epitopes and used to raise polyclonal rabbit antisera. Using these sera, the same expression pattern of RAP-1 proteins was found in parasites cultivated in vitro or collected from acute infection whereas only RAP-1a67 was detectable in merozoite extracts. However, ELISA performed with recombinant RAP-1a67, RAP-1b or RAP-1c and sera from infected sheep demonstrated that RAP-1a67 is the main RAP-1 recognized during infection, even if some infected sheep also recognized RAP-1b and/or RAP-1c.

  7. New Mexico state information handbook formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Informaion Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  8. New York state information handbook formerly utilized sites remedial action program

    SciTech Connect

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying our the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New York. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  9. New Mexico state information handbook: formerly utilized sites remedial action program

    SciTech Connect

    2014-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  10. Integrating RAP in Public Schools: Successes and Challenges

    ERIC Educational Resources Information Center

    Shields, Julie; Milstein, Mindy; Posner, Sandi Ives

    2010-01-01

    For students with emotional disability (ED), school can be a stressful experience marked by disapproval, rejection, isolation, and shame. Staff serving these students in a large school district received Response Ability Pathways (RAP) training. This article summarizes positive impacts on behavior, as well as ongoing challenges in changing school…

  11. Characterize RAP80, a Potential Tumor Suppressor Gene

    DTIC Science & Technology

    2009-04-01

    Fanconi anemia complementation group D2 ( FANCD2 ). However, RAP80 foci still form normally after irradiation in FANCD2 -deficient cells (fig. S7...encoding HSJ1A and Ubi-GST, respectively; and A. D’Andrea for providing FANCD2 -deficient and FANCD2 -reconstituted cells. This work was supported by grants

  12. Multilingual Codeswitching in Quebec Rap: Poetry, Pragmatics and Performativity

    ERIC Educational Resources Information Center

    Sarkar, Mela; Winer, Lise

    2006-01-01

    Quebec rap lyrics stand out on the world Hip-Hop scene by virtue of the ease and rapidity with which performers in this multilingual, multiethnic youth community codeswitch, frequently among three or more languages or language varieties (usually over a French and/or English base) in the same song. We construct a framework for understanding…

  13. A Health Newsletter To Teach Science Knowledge: BioRAP!

    ERIC Educational Resources Information Center

    Froman, Robin D.; Owen, Steven V.; Del Rio-Parent, Lourdes

    This research describes the evaluation of a science curriculum newsletter called BioRAP which serves as a vehicle to teach current health science content. The research objectives were to estimate the relationships of socioeconomic status, ethnic group, gender, grade, student ability, and classroom use characteristics with student knowledge and…

  14. Creating the Infrastructure for Organizational Change with RAP

    ERIC Educational Resources Information Center

    Shields, Julie; Milstein, Mindy; Robinson, Consuela

    2012-01-01

    In order to thrive, organizations must undergo significant change at various points in their development. Such is the case with Montgomery County Public Schools (MCPS) Emotional Disability Services in the beginning process of implementing Response Ability Pathways (RAP) with staff and students. The impetus for change originated from an…

  15. Escaping Embarrassment: Face-Work in the Rap Cipher

    ERIC Educational Resources Information Center

    Lee, Jooyoung

    2009-01-01

    How do individuals escape embarrassing moments in interaction? Drawing from ethnographic fieldwork, in-depth interviews, and video recordings of weekly street corner ciphers (impromptu rap sessions), this paper expands Goffman's theory of defensive and protective face-work. The findings reveal formulaic and indirect dimensions of face-work. First,…

  16. Rap Therapy? An Innovative Approach to Groupwork with Urban Adolescents.

    ERIC Educational Resources Information Center

    DeCarlo, Alonzo

    2001-01-01

    Describes a study in which young, urban African American adolescents with behavior problems participated in weekly group sessions that used rap music to promote the development of appropriate social skills related to morality, identity, judgement, decision making, anger management, impulse control, and crime and punishment. Overall, student…

  17. Rap Music by Black Male Artists: A Psychotheological Interpretation.

    ERIC Educational Resources Information Center

    Pressley, Arthur

    1992-01-01

    Provides a psychotheological interpretation of rap music by African-American male artists and of its audience, examining the music and its social context. Common themes include despair over acute psychosocial and physical needs, intensity and violence as a means of personal integration, ontological insecurity, and desire for transformation and…

  18. Fresh Out of School: Rap Music's Discursive Battle with Education

    ERIC Educational Resources Information Center

    Au, Wayne

    2005-01-01

    The rap music lyrics were analyzed to flush out the hip-hop culture's perspective on the education of African American (AA) youth. It was found that there is a need for the implementation of more culturally relevant curricula in schools, which benefits the students to understand hip-hop culture.

  19. Hybrid Texts: Fifth Graders, Rap Music, and Writing

    ERIC Educational Resources Information Center

    Christianakis, Mary

    2011-01-01

    Consistent with a sociocritical frame and the analytic tools of hybridity theory, this article explicates how urban fifth-grade children made language hybrids using rap and poetry to participate in classroom literacy. Ethnographic data from a yearlong study illustrate two key findings. First, standards-based and canon-driven writing models…

  20. Teaching Literacy as Rap at Southeast Community College.

    ERIC Educational Resources Information Center

    Sundeen, Jim

    2003-01-01

    Describes how the author became critically aware of the dynamics of literacy and race in a composition classroom. Introduces his students to rap music as a legitimate literacy and a type of literature in its own right. Describes the lesson plan he used in the project and explains some of the theory that inspired his classroom inquiry. (SG)

  1. Myofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes.

    PubMed

    Manisastry, Shyam M; Zaal, Kristien J M; Horowits, Robert

    2009-07-15

    N-RAP is a striated muscle-specific scaffolding protein that organizes alpha-actinin and actin into symmetrical I-Z-I structures in developing myofibrils. Here we determined the order of events during myofibril assembly through time-lapse confocal microscopy of cultured embryonic chick cardiomyocytes coexpressing fluorescently tagged N-RAP and either alpha-actinin or actin. During de novo myofibril assembly, N-RAP assembled in fibrillar structures within the cell, with dots of alpha-actinin subsequently organizing along these structures. The initial fibrillar structures were reminiscent of actin fibrils, and coassembly of N-RAP and actin into newly formed fibrils supported this. The alpha-actinin dots subsequently broadened to Z-lines that were wider than the underlying N-RAP fibril, and N-RAP fluorescence intensity decreased. FRAP experiments showed that most of the alpha-actinin dynamically exchanged during all stages of myofibril assembly. In contrast, less than 20% of the N-RAP in premyofibrils was exchanged during 10-20 min after photobleaching, but this value increased to 70% during myofibril maturation. The results show that N-RAP assembles into an actin containing scaffold before alpha-actinin recruitment; that the N-RAP scaffold is much more stable than the assembling structural components; that N-RAP dynamics increase as assembly progresses; and that N-RAP leaves the structure after assembly is complete.

  2. Installation and operation of a large scale RAPS system in Peru

    NASA Astrophysics Data System (ADS)

    Cole, J. F.

    In 1997, International Lead Zinc Research Organization Inc. (ILZRO), Solar Energy Industries Association (SEIA), and the Ministry of Energy and Mines (MEM) of Peru signed a Memorandum of Understanding to facilitate the installation of hybrid remote area power supply (RAPS) systems in the Amazon region of Peru. Many remote villages in this vast region have either no or limited electricity supplied by diesel generators running a few hours per day. Subsequently, ILZRO sponsored the engineering design of the hybrid RAPS system and SEIA supported a socio-economic study to determine the sustainability of such systems and the locations for pilot installations. In mid-1998, the Peruvian government approved the design of the system. ILZRO then began efforts to obtain governmental and inter-governmental funding to supplement its own funds to underwrite the cost of manufacture and installation of the systems in two villages in the Amazon region. Additional major funding has been received from the Global Environmental Facility (GEF) administered by the United Nations Development Program (UNDP) and from the Common Fund for Commodities (CFC). Funds have also been received from the US Department of Energy, the International Greenhouse Partnership (Australia) and the Peruvian government. The RAPS system consists of modules designed to provide 150 kW h per day of utility grade ac electricity over a 24 h period. Each module contains a diesel generator, battery bank using heavy-duty 2 V VRLA GEL batteries, a battery charger, a photovoltaic array and an ac/dc inverter. The batteries and electrical components are housed in modified shipping containers. The modules can be installed with a new generator or retrofitted to an existing generator. The charging and discharging regime of the batteries has been recommended by a study carried out by CSIRO, which has simulated the RAPS operation. The system will employ a partial-state-of-charge (PSOC) regime in order to optimize the life of the

  3. Formerly Used Sites Remedial Action Program (FUSRAP) W. R. Grace Building 23 Remedial Action-Challenges and Successes - 12247

    SciTech Connect

    Barber, Brenda; Honerlah, Hans; O'Neill, Mike; Young, Carl

    2012-07-01

    : coordination with stakeholders, coordination between multiple RA contractors, addressing unique structural challenges for Building 23, nonradiological hazards associated with the RA, weather issues, and complex final status survey (FSS) coordination. The challenges during the Phase 1 RA were handled successfully. The challenges for the Phase 2 RA, which is anticipated to be complete by late-summer of 2012, have been handled successfully so far. By fall of 2012, USACE is expecting to finalize a robust RA Closure Report, including the Final Status Survey Report, which summarizes the RA activities and documents compliance with the ROD. During the ongoing RA at Building 23, there have been and still are many challenges both technically and from a project management perspective, due in part to the nature and extent of impact at the site (residual radioactivity within an active processing building), dual oversight by the property owner and USACE, and site-specific challenges associated with a complex RA and multiple contractors. Currently, USACE and its industry partner are overseeing the completion of RA field activities. RA closure documentation for the remediation of Building 23 to address residual contamination in building materials will be reviewed/approved by USACE and its industry partner upon completion of the field activities. USACE and its industry partner are working well together, through the Settlement Agreement, to conduct a cost-efficient and effective remedial action to address the legacy issues at Building 23. This cooperative effort has set a firm foundation for achieving a successful RA at the RWDA using a 'forward think' approach, and it is a case study for other sites where an industry partner is involved. The collaborative effort led to implementation of an RA which is acceptable to the site owner, the regulators, and the public, thus allowing USACE to move this project forward successfully in the FUSRAP program. (authors)

  4. NASA Education and Educational Technologies Exemplified by the Space Weather Action Center Program

    NASA Astrophysics Data System (ADS)

    Reis, Norma Teresinha Oliveira; André, Claudio; Cline, Troy D.; Eastman, Timothy E.; Maher, Margaret J.; Mayo, Louis A.; Lewis, Elaine M.

    We explore here the Space Weather Action Center (SWAC) Program, as an example of NASA initiatives in education. Many human activities in space can be disrupted by space weather. The main objective of this program is to enable students to produce space weather forecasts by accessing current NASA data. Implementation of the SWAC Program requires: technological resources, online materials, and systematic work. Instructional guides, materials and methods are explained on the Space Weather Action Center Web site (http://sunearthday.nasa.gov/swac). Ultimately, students’ forecasts can be presented through a variety of accessible media including inexpensive video editing software and/or already existing school-based broadcast studios. This cross-curricular program is targeted to middle and high school and can be applied in almost all educational contexts as the number of schools with computer and internet access increases worldwide. SWAC is a pioneer initiative that contributes to fostering student interest in STEM and promotes their intellectual autonomy. Through SWAC, they get to act like real scientists by accessing, analyzing, recording, and communicating space weather forecasts in a professional approach.

  5. Failing better: The stochastic art of evaluating community-led environmental action programs.

    PubMed

    Dunkley, Ria A; Franklin, Alex

    2017-02-01

    This article provides insights into the evaluation of a government-funded action for climate change program. The UK-based program aimed to reduce CO2 emissions and encourage behavioral change through community-led environmental projects. It, thus, employed six community development facilitators, with expertise in environmental issues. These facilitators supported and learnt from 18 community groups over an 18-month period. The paper explores the narratives of the six professional facilitators. These facilitators discuss their experiences of supporting community groups. They also explain their contribution to the wider evaluation of the community-led projects. This paper reflects on the facilitator experience of the program's outcome-led evaluation process. In turn, it also explores how the groups they supported experienced the process. The facilitator's narratives reveal that often community-group objectives did not align with predefined outcomes established through theory of change or logic model methodologies, which had been devised in attempt to align to program funder aims. Assisting community action emerges in this inquiry as a stochastic art that requires funder and facilitator willingness to experiment and openness to the possibilities of learning from failure. Drawing on in-depth accounts, the article illustrates that a reflexive, interpretive evaluation approach can enhance learning opportunities and provides funders with more trustworthy representations of community-led initiatives. Yet, it also addresses why such an approach remains marginal within policy circles.

  6. Assessment of the NASA Space Shuttle Program's Problem Reporting and Corrective Action System

    NASA Technical Reports Server (NTRS)

    Korsmeryer, D. J.; Schreiner, J. A.; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper documents the general findings and recommendations of the Design for Safety Programs Study of the Space Shuttle Programs (SSP) Problem Reporting and Corrective Action (PRACA) System. The goals of this Study were: to evaluate and quantify the technical aspects of the SSP's PRACA systems, and to recommend enhancements addressing specific deficiencies in preparation for future system upgrades. The Study determined that the extant SSP PRACA systems accomplished a project level support capability through the use of a large pool of domain experts and a variety of distributed formal and informal database systems. This operational model is vulnerable to staff turnover and loss of the vast corporate knowledge that is not currently being captured by the PRACA system. A need for a Program-level PRACA system providing improved insight, unification, knowledge capture, and collaborative tools was defined in this study.

  7. Creating the Action Model for High Risk Infant Follow Up Program in Iran

    PubMed Central

    Heidarzadeh, Mohammad; Jodiery, Behzad; Mirnia, Kayvan; Akrami, Forouzan; Hosseini, Mohammad Bagher; Heidarabadi, Seifollah; HabibeLahi, Abbas

    2013-01-01

    Abstract Background Intervention in early childhood development as one of the social determinants of health, is important for reducing social gap and inequity. In spite of increasingly developing intensive neonatal care wards and decreasing neonatal mortality rate, there is no follow up program in Iran. This study was carreid out to design high risk infants follow up care program with the practical aim of creating an model action for whole country, in 2012. Methods This qualitative study has been done by the Neonatal Department of the Deputy of Public Health in cooperation with Pediatrics Health Research Center of Tabriz University of Medical Sciences, Iran. After study of international documents, consensus agreement about adapted program for Iran has been accomplished by focus group discussion and attended Delphi agreement technique. After compiling primary draft included evidence based guidelines and executive plan, 14 sessions including expert panels were hold to finalize the program. Results After finalizing the program, high risk infants follow up care service package has been designed in 3 chapters: Evidence based clinical guidelines; eighteen main clinical guidelines and thirteen subsidiaries clinical guidelines, executive plan; 6 general, 6 following up and 5 backup processes. Education program including general and especial courses for care givers and follow up team, and family education processes. Conclusion We designed and finalized high risk infants follow up care service package. It seems to open a way to extend it to whole country. PMID:26171344

  8. Annual status report on the Uranium Mill Tailings Remedial Action Program

    SciTech Connect

    Not Available

    1989-12-01

    This eleventh annual status report summarizes activities of the Uranium Mill Tailings Remedial Action (UMTRA) Project undertaken during Fiscal Year (FY) 1989 by the US Department of Energy (DOE) and other agencies. Project goals for FY 1990 are also presented. An annual report of this type was a statutory requirement through January 1, 1986, pursuant to the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law (PL) 95--604. The DOE will continue to submit an annual report through project completion in order to inform the public of yearly project status. Title I of the UMTRCA authorizes the DOE, in cooperation with affected states and Indian tribes within whose boundaries designated uranium processing sites are located, to provide a program of assessment and remedial action at such sites. The purpose of the remedial action is to stabilize and control the tailings and other residual radioactive materials located on the inactive uranium processing sites in a safe and environmentally sound manner and to minimize or eliminate potential radiation health hazards. Commercial and residential properties in the vicinity of designated processing sites that are contaminated with material from the sites, herein referred to as vicinity properties,'' are also eligible for remedial action. Included in the UMTRA Project are 24 inactive uranium processing sites and associated vicinity properties located in 10 states, and the vicinity properties associated with Edgemont, South Dakota, an inactive uranium mill currently owned by the Tennessee Valley Authority (TVA).

  9. Cloning and characterization of Rap GTPase from the Chinese white shrimp Fenneropenaeus chinensis.

    PubMed

    Ren, Qian; Zhou, Jing; Jia, Yu-Ping; Wang, Xian-Wei; Zhao, Xiao-Fan; Wang, Jin-Xing

    2012-01-01

    Ras-related protein Rap GTPase has been implicated in cell adhesion, cell proliferation, and cell junction formation. The first shrimp Rap cDNA (FcRap) was recently identified from the Chinese white shrimp Fenneropenaeus chinensis. The full length of FcRap is 1013 bp, with a 561 bp open reading frame that encodes a 186 amino acid protein. FcRap has a calculated molecular mass of 20.90 kDa and pI of 6.37. Phylogenetic analysis shows that FcRap and other Rap proteins are clustered into one group. Results from the quantitative real-time polymerase chain reaction show that FcRap could be detected mainly in the hemocytes, hepatopancreas, stomach, and gills, whereas a relatively lower expression level could be detected in the heart and intestines. FcRap in the hemocytes was upregulated 2h post Vibrio challenge, and it was upregulated 2h post white spot syndrome virus (WSSV) challenge, and peaked at 6h before it declined at 12h. No variation in the FcRap transcript was observed in the gills under the Vibrio challenge, but it was initially downregulated 2h post WSSV challenge, and then it was upregulated and peaked at 6h before it was eventually went down at 12h. The rFcRap protein was successfully expressed in Escherichia coli BL21DE3. The pull-down analysis showed that rFcRap protein could interact with VP28, an envelope protein of WSSV. The probable roles of Rap GTPase in shrimp innate immunity are presented for the first time.

  10. Neural correlates of lyrical improvisation: an FMRI study of freestyle rap.

    PubMed

    Liu, Siyuan; Chow, Ho Ming; Xu, Yisheng; Erkkinen, Michael G; Swett, Katherine E; Eagle, Michael W; Rizik-Baer, Daniel A; Braun, Allen R

    2012-01-01

    The neural correlates of creativity are poorly understood. Freestyle rap provides a unique opportunity to study spontaneous lyrical improvisation, a multidimensional form of creativity at the interface of music and language. Here we use functional magnetic resonance imaging to characterize this process. Task contrast analyses indicate that improvised performance is characterized by dissociated activity in medial and dorsolateral prefrontal cortices, providing a context in which stimulus-independent behaviors may unfold in the absence of conscious monitoring and volitional control. Connectivity analyses reveal widespread improvisation-related correlations between medial prefrontal, cingulate motor, perisylvian cortices and amygdala, suggesting the emergence of a network linking motivation, language, affect and movement. Lyrical improvisation appears to be characterized by altered relationships between regions coupling intention and action, in which conventional executive control may be bypassed and motor control directed by cingulate motor mechanisms. These functional reorganizations may facilitate the initial improvisatory phase of creative behavior.

  11. Neural Correlates of Lyrical Improvisation: An fMRI Study of Freestyle Rap

    PubMed Central

    Liu, Siyuan; Chow, Ho Ming; Xu, Yisheng; Erkkinen, Michael G.; Swett, Katherine E.; Eagle, Michael W.; Rizik-Baer, Daniel A.; Braun, Allen R.

    2012-01-01

    The neural correlates of creativity are poorly understood. Freestyle rap provides a unique opportunity to study spontaneous lyrical improvisation, a multidimensional form of creativity at the interface of music and language. Here we use functional magnetic resonance imaging to characterize this process. Task contrast analyses indicate that improvised performance is characterized by dissociated activity in medial and dorsolateral prefrontal cortices, providing a context in which stimulus-independent behaviors may unfold in the absence of conscious monitoring and volitional control. Connectivity analyses reveal widespread improvisation-related correlations between medial prefrontal, cingulate motor, perisylvian cortices and amygdala, suggesting the emergence of a network linking motivation, language, affect and movement. Lyrical improvisation appears to be characterized by altered relationships between regions coupling intention and action, in which conventional executive control may be bypassed and motor control directed by cingulate motor mechanisms. These functional reorganizations may facilitate the initial improvisatory phase of creative behavior. PMID:23155479

  12. “Everybody Gotta Have a Dream”: Rap-centered Aspirations among Young Black Males Involved in Rap Music Production – A Qualitative Study

    PubMed Central

    Foster, B. Brian

    2015-01-01

    Youth express diverse desires for their educational and occupational futures. Sometimes these aspirations are directed towards somewhat unconventional careers such as rapping and other types of involvement in rap music production. Although many studies have examined traditional educational and occupational aspirations, less is known about the factors that give rise to rap-centered aspirations and how individuals pursue them, particularly as they transition to early adulthood. Drawing on 54 semi- and unstructured interviews with 29 black young men involved in rap music production, I find that rap-centered aspirations are shaped by a range of factors, most notably feedback regarding one’s rap skills, access to recording and production equipment, and the financial means to maintain involvement in rap music production while also ensuring personal and family economic stability. The young men in the study attached different meanings to their aspirations and sometimes recast their motivations for participating in rap music production in response to various social and economic factors. PMID:26005703

  13. Environmental compliance assessment findings for Weldon Spring Site Remedial Action Program

    SciTech Connect

    Sigmon, C.F.; Levine, M.B.

    1990-03-02

    This report presents the results of an environmental assessment conducted at Weldon Spring Site Remedial Action Project (WSSRAP) in St. Charles County, Missouri, in accordance with the Formerly Utilized Sites Remedial Action Program (FUSRAP) Environmental Compliance Assessment Checklists. The purpose of this assessment was to evaluate the compliance of the site with applicable federal and Missouri environment regulations. Assessments activities included the following: review of site records, reports ,and files; inspection of the WSSRAP storage building, other selected buildings, and the adjacent grounds; and interviews with project personnel. This assessment was conducted on August 28-30, 1989. The assessment covered five management areas as set forth in the Checklist: Hazardous Waste Management, Polychlorinated Biphenyls (PCBs) Management; Air Emissions; Wastewater Discharges and Petroleum Management. No samples were collected. 1 ref., 2 figs., 1 tab.

  14. NREL's Education Program in Action in the Concentrating Solar Power Program Advanced Materials Task

    NASA Astrophysics Data System (ADS)

    Kennedy, Cheryl

    2010-03-01

    Concentrating solar power (CSP) technologies use large mirrors to concentrate sunlight and the thermal energy collected is converted to electricity. The CSP industry is growing rapidly and is expected to reach 25 GW globally by 2020. Cost target goals are for CSP technologies to produce electricity competitive with intermediate-load power generation (i.e., natural gas) by 2015 with 6 hours of thermal storage and competitive in carbon constrained base load power markets (i.e., coal) by 2020 with 12-17 hours of thermal storage. The solar field contributes more than 40% of the total cost of a parabolic trough plant and together the mirrors and receivers contribute more than 25% of the installed solar field cost. CSP systems cannot hit these targets without aggressive cost reductions and revolutionary performance improvements from technology advances. NREL's Advanced Materials task in the CSP Advanced R&D project performs research to develop low cost, high performance, durable solar reflector and high-temperature receiver materials to meet these needs. The Advanced Materials task leads the world in this research and the task's reliance on NREL's educational program will be discussed.

  15. Reducing cyberbullying: A theory of reasoned action-based video prevention program for college students.

    PubMed

    Doane, Ashley N; Kelley, Michelle L; Pearson, Matthew R

    2016-01-01

    Few studies have evaluated the effectiveness of cyberbullying prevention/intervention programs. The goals of the present study were to develop a Theory of Reasoned Action (TRA)-based video program to increase cyberbullying knowledge (1) and empathy toward cyberbullying victims (2), reduce favorable attitudes toward cyberbullying (3), decrease positive injunctive (4) and descriptive norms about cyberbullying (5), and reduce cyberbullying intentions (6) and cyberbullying behavior (7). One hundred sixty-seven college students were randomly assigned to an online video cyberbullying prevention program or an assessment-only control group. Immediately following the program, attitudes and injunctive norms for all four types of cyberbullying behavior (i.e., unwanted contact, malice, deception, and public humiliation), descriptive norms for malice and public humiliation, empathy toward victims of malice and deception, and cyberbullying knowledge significantly improved in the experimental group. At one-month follow-up, malice and public humiliation behavior, favorable attitudes toward unwanted contact, deception, and public humiliation, and injunctive norms for public humiliation were significantly lower in the experimental than the control group. Cyberbullying knowledge was significantly higher in the experimental than the control group. These findings demonstrate a brief cyberbullying video is capable of improving, at one-month follow-up, cyberbullying knowledge, cyberbullying perpetration behavior, and TRA constructs known to predict cyberbullying perpetration. Considering the low cost and ease with which a video-based prevention/intervention program can be delivered, this type of approach should be considered to reduce cyberbullying.

  16. Computed tomography screening: the international early lung cancer action program experience.

    PubMed

    Henschke, Claudia I; Boffetta, Paolo; Yankelevitz, David F; Altorki, Nasser

    2015-05-01

    The International Early Lung Cancer Action Program (I-ELCAP) used a novel study design that provided quantitative information about annual CT screening for lung cancer. The results stimulated additional studies of lung cancer screening and ultimately led to the National Lung Screening Trial (NLST) being initiated in 2002, as the initial report in 1999 was sufficiently compelling to reawaken interest in screening for lung cancer. The authors think that the I-ELCAP and NLST "story" provides a strong argument for relevant agencies to consider alternative study designs for the public funding of studies aimed at evaluating the effectiveness of screening and other medical trials.

  17. Comparative Qualitative Research Distinguishing Safety Features Among Aviation Safety Action Programs in the United States Airlines

    NASA Astrophysics Data System (ADS)

    Chilakalapudi, Naga Swathi Kiran

    Over the years, aviation safety has been influenced by continuous implementations of both proactive and reactive policies by both regulatory boards and also, aviation service providers. This achievement has been possible mainly because of the safety management tools like the Aviation Safety Action Program (ASAP) which derives its roots from the much earlier Aviation Safety Reporting System (ASRS). Federal Aviation Administration (FAA) provides guidelines and procedures for installation and development of an ASAP, for every airline in the United States. In this study, how different United States air carriers apply ASAP in their organizations is investigated.

  18. 13 CFR 120.1425 - Grounds for enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Grounds for enforcement actions-Intermediaries participating in the Microloan Program and NTAPs. 120.1425 Section 120.1425 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions §...

  19. 13 CFR 120.1540 - Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Types of enforcement actions-Intermediaries participating in the Microloan Program and NTAPs. 120.1540 Section 120.1540 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Risk-Based Lender Oversight Enforcement Actions §...

  20. Training School Personnel to Implement a Universal School-Based Prevention of Depression Program under Real-World Conditions

    ERIC Educational Resources Information Center

    Harnett, P.H.; Dadds, M.R.

    2004-01-01

    The present study evaluated the impact of a universal prevention of depression program [the Resourceful Adolescent Program (RAP)] when implemented under real-world conditions in a school setting. Prior research has found the RAP program to be beneficial for high-school students when the program was implemented by university staff selected,…

  1. Assisted annotation of medical free text using RapTAT

    PubMed Central

    Gobbel, Glenn T; Garvin, Jennifer; Reeves, Ruth; Cronin, Robert M; Heavirland, Julia; Williams, Jenifer; Weaver, Allison; Jayaramaraja, Shrimalini; Giuse, Dario; Speroff, Theodore; Brown, Steven H; Xu, Hua; Matheny, Michael E

    2014-01-01

    Objective To determine whether assisted annotation using interactive training can reduce the time required to annotate a clinical document corpus without introducing bias. Materials and methods A tool, RapTAT, was designed to assist annotation by iteratively pre-annotating probable phrases of interest within a document, presenting the annotations to a reviewer for correction, and then using the corrected annotations for further machine learning-based training before pre-annotating subsequent documents. Annotators reviewed 404 clinical notes either manually or using RapTAT assistance for concepts related to quality of care during heart failure treatment. Notes were divided into 20 batches of 19–21 documents for iterative annotation and training. Results The number of correct RapTAT pre-annotations increased significantly and annotation time per batch decreased by ∼50% over the course of annotation. Annotation rate increased from batch to batch for assisted but not manual reviewers. Pre-annotation F-measure increased from 0.5 to 0.6 to >0.80 (relative to both assisted reviewer and reference annotations) over the first three batches and more slowly thereafter. Overall inter-annotator agreement was significantly higher between RapTAT-assisted reviewers (0.89) than between manual reviewers (0.85). Discussion The tool reduced workload by decreasing the number of annotations needing to be added and helping reviewers to annotate at an increased rate. Agreement between the pre-annotations and reference standard, and agreement between the pre-annotations and assisted annotations, were similar throughout the annotation process, which suggests that pre-annotation did not introduce bias. Conclusions Pre-annotations generated by a tool capable of interactive training can reduce the time required to create an annotated document corpus by up to 50%. PMID:24431336

  2. Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis.

    PubMed

    Minato, Nagahiro; Hattori, Masakazu

    2009-01-01

    Although Rap GTPases of the Ras family remained enigmatic for years, extensive studies in this decade have revealed diverse functions of Rap in the control of cell proliferation, differentiation, survival, adhesion, and movement. With the use of genetic engineering strategies, we have uncovered essential roles of Rap signaling in normal lymphohematopoietic cell development as well as its crucial involvement in the development of a wide spectrum of leukemia in manners highly dependent on the contexts of cell lineages. Incidentally, recent results also indicate an important role of Spa-1, a Rap GTPase-activating protein, in invasion and metastasis in human cancers. While it is unlikely that Rap can function as a classic oncogene by itself, like Ras, emerging findings unveil crucial involvements of Rap GTPases in the distinct aspects of malignancy, including leukemia genesis and cancer metastasis.

  3. PRL-3 activates NF-κB signaling pathway by interacting with RAP1.

    PubMed

    Lian, Shenyi; Meng, Lin; Liu, Caiyun; Xing, Xiaofang; Song, Qian; Dong, Bin; Han, Yong; Yang, Yongyong; Peng, Lirong; Qu, Like; Shou, Chengchao

    2013-01-04

    Phosphatase of regenerating liver (PRL-3) promotes cancer metastasis through enhanced cell motility and invasiveness, however its role in tumorigenesis remains unclear. Herein, we reported that PRL-3 interacts with telomere-related protein RAP1. PRL-3 promotes the cytosolic localization of RAP1, which is counteracted by silencing of PRL-3. Immunohistochemical staining of colon cancer tissue array (n=170) revealed that high level of PRL-3 associates with cytosolic localization of RAP1 (p=0.01). Microarray analysis showed that PRL-3 regulates expression of diverse genes and enhances phosphorylation of p65 subunit of NF-κB in a RAP1-dependent manner. Furthermore, PRL-3 transcriptionally activates RAP1 expression, which is counteracted by ablating p65. Therefore, our results demonstrate PRL-3 as a novel regulator of NF-κB signaling pathway through RAP1.

  4. Final Record of Decision/Remedial Action Plan, Nine Sites, Sierra Army Depot, Lassen County, California.

    DTIC Science & Technology

    1996-10-01

    section provides the declaration portion of the ROD /RAP for the Construction Debris Landfill. 5.1.1 Location The Construction Debris Landfill is...and Role of Response Action This ROD /RAP presents the final response action for the Construction Debris Landfill. This site poses no potential threat...AMMUNITION DEMILITARIZATION AND RENOVATION AREA BUILDING 1003 AREA CHEMICAL BURIAL SITE CONSTRUCTION DEBRIS LANDFILL EXISTING LANDFILL EXISTING

  5. Uranium Mill Tailings Remedial Action Project: Cost Reduction and Productivity Improvement Program Project Plan. Revised

    SciTech Connect

    Not Available

    1991-11-01

    The purpose of the Cost Reduction/Productivity Improvement Program Plan is to formalize and improve upon existing efforts to control costs which have been underway since project inception. This program plan has been coordinated with the Department of Energy (DOE) Office of Environmental Management (EM) and the DOE Field Office, Albuquerque (AL). It incorporates prior Uranium Mill Tallings Remedial Action (UMTRA) Project Office guidance issued on the subject. The opportunities for reducing cosh and improving productivity are endless. The CR/PIP has these primary objectives: Improve productivity and quality; heighten the general cost consciousness of project participants, at all levels of their organizations; identify and implement specific innovative employee ideas that extend beyond what is required through existing processes and procedures; emphasize efforts that create additional value for the money spent by maintaining the project Total Estimated Cost (TEC) at the lowest possible level.

  6. Uranium Mill Tailings Remedial Action Project: Cost Reduction and Productivity Improvement Program Project Plan

    SciTech Connect

    Not Available

    1991-11-01

    The purpose of the Cost Reduction/Productivity Improvement Program Plan is to formalize and improve upon existing efforts to control costs which have been underway since project inception. This program plan has been coordinated with the Department of Energy (DOE) Office of Environmental Management (EM) and the DOE Field Office, Albuquerque (AL). It incorporates prior Uranium Mill Tallings Remedial Action (UMTRA) Project Office guidance issued on the subject. The opportunities for reducing cosh and improving productivity are endless. The CR/PIP has these primary objectives: Improve productivity and quality; heighten the general cost consciousness of project participants, at all levels of their organizations; identify and implement specific innovative employee ideas that extend beyond what is required through existing processes and procedures; emphasize efforts that create additional value for the money spent by maintaining the project Total Estimated Cost (TEC) at the lowest possible level.

  7. Development of a Wheelchair Skills Home Program for Older Adults Using a Participatory Action Design Approach

    PubMed Central

    Giesbrecht, Edward M.; Miller, William C.; Mitchell, Ian M.; Woodgate, Roberta L.

    2014-01-01

    Restricted mobility is the most common impairment among older adults and a manual wheelchair is often prescribed to address these limitations. However, limited access to rehabilitation services results in older adults typically receiving little or no mobility training when they receive a wheelchair. As an alternative and novel approach, we developed a therapist-monitored wheelchair skills home training program delivered via a computer tablet. To optimize efficacy and adherence, principles of self-efficacy and adult learning theory were foundational in the program design. A participatory action design approach was used to engage older adult wheelchair users, care providers, and prescribing clinicians in an iterative design and development process. A series of prototypes were fabricated and revised, based on feedback from eight stakeholder focus groups, until a final version was ready for evaluation in a clinical trial. Stakeholder contributions affirmed and enhanced the foundational theoretical principles and provided validation of the final product for the target population. PMID:25276768

  8. Development of a wheelchair skills home program for older adults using a participatory action design approach.

    PubMed

    Giesbrecht, Edward M; Miller, William C; Mitchell, Ian M; Woodgate, Roberta L

    2014-01-01

    Restricted mobility is the most common impairment among older adults and a manual wheelchair is often prescribed to address these limitations. However, limited access to rehabilitation services results in older adults typically receiving little or no mobility training when they receive a wheelchair. As an alternative and novel approach, we developed a therapist-monitored wheelchair skills home training program delivered via a computer tablet. To optimize efficacy and adherence, principles of self-efficacy and adult learning theory were foundational in the program design. A participatory action design approach was used to engage older adult wheelchair users, care providers, and prescribing clinicians in an iterative design and development process. A series of prototypes were fabricated and revised, based on feedback from eight stakeholder focus groups, until a final version was ready for evaluation in a clinical trial. Stakeholder contributions affirmed and enhanced the foundational theoretical principles and provided validation of the final product for the target population.

  9. Lessons Learned for Cx PRACA. Constellation Program Problem Reporting, Analysis and Corrective Action Process and System

    NASA Technical Reports Server (NTRS)

    Kelle, Pido I.; Ratterman, Christian; Gibbs, Cecil

    2009-01-01

    This slide presentation reviews the Constellation Program Problem Reporting, Analysis and Corrective Action Process and System (Cx PRACA). The goal of the Cx PRACA is to incorporate Lessons learned from the Shuttle, ISS, and Orbiter programs by creating a single tool for managing the PRACA process, that clearly defines the scope of PRACA applicability and what must be reported, and defines the ownership and responsibility for managing the PRACA process including disposition approval authority. CxP PRACA is a process, supported by a single information gathering data module which will be integrated with a single CxP Information System, providing interoperability, import and export capability making the CxP PRACA a more effective and user friendly technical and management tool.

  10. A Randomized Placebo-Controlled Trial of a School-Based Depression Prevention Program.

    ERIC Educational Resources Information Center

    Merry, Sally; McDowell, Heather; Wild, Chris J.; Bir, Julliet; Cunliffe, Rachel

    2004-01-01

    Objective: To conduct a placebo-controlled study of the effectiveness of a universal school-based depression prevention program. Method: Three hundred ninety-two students age 13 to 15 from two schools were randomized to intervention (RAP-Kiwi) and placebo programs run by teachers. RAP-Kiwi was an 11-session manual-based program derived from…

  11. Overview of the U.S. Department of Energy Formerly Utilized Sites Remedial Action Program - 12189

    SciTech Connect

    Clayton, Christopher; Kothari, Vijendra; Starr, Ken; Gillespie, Joey; Widdop, Michael

    2012-07-01

    The U.S. Department of Energy (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to address residual radiological contamination at sites where work was performed for the Manhattan Engineer District and U.S. Atomic Energy Commission. Initially, FUSRAP activities began with a records search for sites that had the potential to contain residual radiological contamination; 46 sites were identified that were eligible for and required remediation. Remedial action began in 1979. In 1997, Congress assigned responsibility for the remediation of FUSRAP sites to the U.S. Army Corps of Engineers (USACE). DOE retains responsibility for determining if sites are eligible for FUSRAP remediation and for providing long-term surveillance and maintenance (LTS and M) of remediated FUSRAP sites. DOE LTS and M activities are designed to ensure that FUSRAP sites remain protective of human health and the environment and to preserve knowledge regarding FUSRAP sites. Additional elements include eligibility determinations, transition of remediated sites from USACE to DOE, LTS and M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close coordination with USACE and regulators to ensure there is no loss of protectiveness when sites transition to DOE for LTS and M. Over the life of the FUSRAP program from 1974 to the present, DOE's primary mission and responsibility has been to ensure that FUSRAP sites remain protective of human health and the environment. In fulfilling this mission, the DOE program includes the following key elements: eligibility determinations, transition of remediated sites from USACE to DOE, LTS and M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close communication stakeholders as well as state and federal regulators. DOE

  12. Clinical next generation sequencing to identify actionable aberrations in a phase I program

    PubMed Central

    Boland, Genevieve M.; Piha-Paul, Sarina A.; Subbiah, Vivek; Routbort, Mark; Herbrich, Shelley M.; Baggerly, Keith; Patel, Keyur P.; Brusco, Lauren; Horombe, Chacha; Naing, Aung; Fu, Siqing; Hong, David S.; Janku, Filip; Johnson, Amber; Broaddus, Russell; Luthra, Raja; Shaw, Kenna; Mendelsohn, John; Mills, Gordon B.; Meric-Bernstam, Funda

    2015-01-01

    Purpose We determined the frequency of recurrent hotspot mutations in 46 cancer-related genes across tumor histologies in patients with advanced cancer. Methods We reviewed data from 500 consecutive patients who underwent genomic profiling on an IRB-approved prospective clinical protocol in the Phase I program at the MD Anderson Cancer Center. Archival tumor DNA was tested for 740 hotspot mutations in 46 genes (Ampli-Seq Cancer Panel; Life Technologies, CA). Results Of the 500 patients, 362 had at least one reported mutation/variant. The most common likely somatic mutations were within TP53 (36%), KRAS (11%), and PIK3CA (9%) genes. Sarcoma (20%) and kidney (30%) had the lowest proportion of likely somatic mutations detected, while pancreas (100%), colorectal (89%), melanoma (86%), and endometrial (75%) had the highest. There was high concordance in 62 patients with paired primary tumors and metastases analyzed. 151 (30%) patients had alterations in potentially actionable genes. 37 tumor types were enrolled; both rare actionable mutations in common tumor types and actionable mutations in rare tumor types were identified. Conclusion Multiplex testing in the CLIA environment facilitates genomic characterization across multiple tumor lineages and identification of novel opportunities for genotype-driven trials. PMID:26015395

  13. [Uranium Mill Tailings Remedial Action Project Office Quality Assurance Program Plan]. Revision 4

    SciTech Connect

    Not Available

    1992-06-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project was established to accomplish remedial actions at inactive uranium mill tailings sites in accordance with Public Law 95-604, the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA). The UMTRA Project`s mission is to stabilize and control the residual radioactive materials at designated sites in a safe and environmentally sound manner so as to minimize or eliminate radiation health hazards to the public. The US Department of Energy (DOE) UMTRA Project Office (UMTRA PO) directs the overall project. Since these efforts may involve possible risks to public health and safety, a quality assurance (QA) program that conforms to the applicable criteria (set forth in the reference documents) has been established to control the quality of the work. This document, the Quality Assurance Program Plan (QAPP), brings into one document the essential criteria to be applied on a selective basis, depending upon the nature of the activity being conducted, and describes how those criteria shall be applied to the UMTRA Project. The UMTRA PO shall require each Project contractor to prepare and submit for approval a more detailed QAPP that is based on the applicable criteria of this QAPP and the referenced documents. All QAPPs on the UMTRA Project shall fit within the framework of this plan.

  14. Alternatives for management of wastes generated by the formerly utilized sites remedial action program and supplement

    SciTech Connect

    Gilbert, T.L.; Peterson, J.M.; Vocke, R.W.; Alexander, J.K.

    1983-03-01

    Alternatives for disposal or stabilization of the wastes generated by the US Department of Energy's Formerly Utilized Sites Remedial Action Program (FUSRAP) are identified and compared, with emphasis on the long-term aspects. These wastes consist of soil material and rubble containing trace amounts of radionuclides. A detailed pathway analysis for the dose to the maximally exposed individual is carried out using an adaptation of the natural analogue method. Comparisons of the different alternatives, based on the results of the pathway analysis and qualitative cost considerations, indicate that, if the hazard is such that the wastes must be removed and disposed of rather than stabilized in place, disposal by immediate dispersal is preferable to containment, and containment followed by slow planned dispersal is preferable to containment without dispersal. The Supplement presents refinements of work that was reported at the 1982 International Decommissioning Symposium. The new material consists of revisions of the estimates of the predicted potential dose to the maximally exposed individual and a more detailed comparative assessment of the radiological impacts of alternatives for management of wastes generated by the US Department of Energy's Formerly Utilized Sites Remedial Action Program (FUSRAP).

  15. [Uranium Mill Tailings Remedial Action Project Office Quality Assurance Program Plan

    SciTech Connect

    Not Available

    1992-06-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project was established to accomplish remedial actions at inactive uranium mill tailings sites in accordance with Public Law 95-604, the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA). The UMTRA Project's mission is to stabilize and control the residual radioactive materials at designated sites in a safe and environmentally sound manner so as to minimize or eliminate radiation health hazards to the public. The US Department of Energy (DOE) UMTRA Project Office (UMTRA PO) directs the overall project. Since these efforts may involve possible risks to public health and safety, a quality assurance (QA) program that conforms to the applicable criteria (set forth in the reference documents) has been established to control the quality of the work. This document, the Quality Assurance Program Plan (QAPP), brings into one document the essential criteria to be applied on a selective basis, depending upon the nature of the activity being conducted, and describes how those criteria shall be applied to the UMTRA Project. The UMTRA PO shall require each Project contractor to prepare and submit for approval a more detailed QAPP that is based on the applicable criteria of this QAPP and the referenced documents. All QAPPs on the UMTRA Project shall fit within the framework of this plan.

  16. Reliability assurance program and its relationship to other regulations

    SciTech Connect

    Polich, T.J.

    1994-12-31

    The need for a safety-oriented reliability effort for the nuclear industry was identified by the U.S. Nuclear Regulatory Commission (NRC) in the Three Mile Island Action Plan (NUREG-0660) Item II.C.4. In SECY-89-013, {open_quotes}Design Requirements Related to the Evolutionary ALWR,{close_quotes} the staff stated that the reliability assurance program (RAP) would be required for design certification to ensure that the design reliability of safety-significant structures, systems, and components (SSCs) is maintained over the life of a plant. In November 1988, the staff informed the advanced light water reactor (ALWR) vendors and the Electric Power Research Institute (EPRI) that it was considering this matter. Since that time, the staff has had numerous interactions with industry regarding RAP. These include discussions and subsequent safety evaluation reports on the EPRI utilities requirements document and for both Evolutionary Designs. The RAP has also been discussed in SECY-93-087, {open_quotes}Policy, Technical, and Licensing Issues Pertaining to Evolutionary and Advanced Light-Water Reactor (ALWR) Designs{close_quotes} and SECY-94-084, {open_quotes}Policy and Technical Issues Associated With the Regulatory Treatment of Non-Safety Systems in Passive Plant Designs.{close_quotes}

  17. Office of Inspector General report on audit of selected hazardous waste remedial actions program costs

    SciTech Connect

    1997-08-01

    In 1986, the Department of Energy (Department) entered into a work-for-others agreement with the Department of the Air Force (Air Force) to provide technical assistance in support of environmental compliance issues. Lockheed Martin Energy System`s (Energy Systems) Hazardous Waste Remedial Actions Program (HAZWRAP) supported the Department in fulfilling its responsibilities to the Air Force. The objective of this audit was to determine if costs charged to selected HAZWRAP customers were in accordance with Department regulations and the terms of the Air Force`s interagency agreement. Energy Systems did not properly manage and account for costs claimed under its interagency agreements for HAZWRAP. Specifically, Energy Systems transferred costs among accounts to avoid overruns and to use the maximum funds authorized by HAZWRAP customers. By avoiding cost overruns, Energy Systems hoped to receive higher award fees from the Department. As a result of its actions, Energy Systems mischarged one HAZWRAP customer by $504,750. It was recommended that the Manager, Oak Ridge Operations Office: (1) direct Energy Systems to ensure that existing management controls are adhered to and that adequate management controls are maintained; (2) determine the allowability of $504,750 in questioned costs, recover the appropriate amount from Energy Systems, and refund mischarged amounts to the appropriate customers; and (3) perform a ``for cause`` review of the Work-for-Others Program to identify, recover, and refund amounts received by Energy Systems as the result of improper cost transfers. Management concurred with the finding and recommendations and agreed to take appropriate action.

  18. Rapid Fabrication of Lightweight SiC Optics using Reactive Atom Plasma (RAP) Processing

    NASA Technical Reports Server (NTRS)

    Fiske, Peter S.

    2006-01-01

    Reactive Atom Plasma (RAP) processing is a non-contact, plasma-based processing technology that can be used to generate damage-free optical surfaces. We have developed tools and processes using RAP that allow us to shape extremely lightweight mirror Surfaces made from extremely hard-to-machine materials (e.g. SiC). We will describe our latest results using RAP in combination with other technologies to produce finished lightweight SiC mirrors and also discuss applications for RAP in the rapid fabrication of mirror segments for reflective and grazing incidence telescopes.

  19. Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group).

    PubMed

    Niu, Qingli; Bonsergent, Claire; Guan, Guiquan; Yin, Hong; Malandrin, Laurence

    2013-11-15

    Babesiosis is a frequent infection of animals worldwide by tick borne pathogen Babesia, and several species are responsible for ovine babesiosis. Recently, several Babesia motasi-like isolates were described in sheep in China. In this study, we sequenced the multigenic rap-1 gene locus of one of these isolates, Babesia sp. BQ1 Lintan. The RAP-1 proteins are involved in the process of red blood cells invasion and thus represent a potential target for vaccine development. A complex composition and organization of the rap-1 locus was discovered with: (1) the presence of 3 different types of rap-1 sequences (rap-1a, rap-1b and rap-1c); (2) the presence of multiple copies of rap-1a and rap-1b; (3) polymorphism among the rap-1a copies, with two classes (named rap-1a61 and rap-1a67) having a similarity of 95.7%, each class represented by two close variants; (4) polymorphism between rap-1a61-1 and rap-1a61-2 limited to three nucleotide positions; (5) a difference of eight nucleotides between rap-1a67-1 and rap-1a67-2 from position 1270 to the putative stop site of rap-1a67-1 which might produce two putative proteins of slightly different sizes; (6) the ratio of rap-1a copies corresponding to one rap-1a67, one rap-1a61-1 and one rap-1a61-2; (7) the presence of three different intergenic regions separating rap-1a, rap-1b and rap-1c; (8) interspacing of the rap-1a copies with rap-1b copies; and (9) the terminal position of rap-1c in the locus. A 31kb locus composed of 6 rap-1a sequences interspaced with 5 rap-1b sequences and with a terminal rap-1c copy was hypothesized. A strikingly similar sequence composition (rap-1a, rap-1b and rap-1c), as well as strong gene identities and similar locus organization with B. bigemina were found and highlight the conservation of synteny at this locus in this phylogenetic clade.

  20. Theory in the Service of Practice: Theories in Action Research Dissertations Written by Students in Education Doctorate Programs

    ERIC Educational Resources Information Center

    Zambo, Debby

    2014-01-01

    Educational leaders are enrolling in second-generation education doctorate (EdD) programs because these are allowing them to remain in the field as they pursue their degree and perform action research within their workplace. As part of degree requirements, students in these programs are challenged to cross the theory-to-practice divide. However,…

  1. The Positive Action Program: Improving Academics, Behavior, and Character by Teaching Comprehensive Skills for Successful Learning and Living

    ERIC Educational Resources Information Center

    Flay, Brian R.; Allred, Carol G.

    2010-01-01

    This chapter outlines and provides evidence for the effects of the "Positive Action Program" as a way of inculcating values, driving student wellbeing, and improving academic performance and interpersonal behavior. The program centers on addressing behavioral, emotional, and academic problems by developing in individuals positive beliefs…

  2. An Exploration of Significant Leadership Development Factors in Action Learning: A Comparison of Three Action Learning Programs

    ERIC Educational Resources Information Center

    Cowan, Chris Allen

    2013-01-01

    As the need for new leaders has increased, so has the need for new and more effective forms of leadership development (Hamel, 2007; Lojeski, 2010; Gratton, 2011). Action learning has been popularized as one of these new forms of leadership development (Peters & Smith, 1998; Byrnes, 2005; ASTD, 2008; Trehan & Pedler, 2011). However,…

  3. Yakima Tributary Access and Habitat Program : Action Plan Final Report 2002.

    SciTech Connect

    Myra, David; Ready, Carol A.

    2003-04-01

    This report covers activities conducted by the Yakima Tributary Access and Habitat Program under Bonneville Power Administration (BPA) grant project No. 2002-025-00 for fiscal year 2002. The Yakima Tributary Access and Habitat Program (YTAHP, Program) was organized to restore salmonid passage to Yakima tributaries that historically supported salmonids and improve habitat in areas where access is restored. Specifically, this program is designed to (a) screen unscreened diversion structures to prevent fish entrainment into artificial waterways; (b) provide for fish passage at man-made barriers, such as diversion dams, culverts, siphons and bridges; and (c) provide information and assistance to landowners interested in to contributing to the improvement of water quality, water reliability and stream habitat. The YTAHP developed from a number of groups actively engaged in watershed management, and/or habitat restoration within the Yakima River Basin. These groups include the Washington State Fish and Wildlife (WDFW), Kittitas County Conservation District (KCCD), North Yakima Conservation District (NYCD), Kittitas County Water Purveyors (KCWP), and Ahtanum Irrigation District (AID). The US Bureau of Reclamation (Reclamation) and Yakama Nation (YN) both participated in the development of the objectives of YTAHP. Other entities that will be involved during permitting or project review may include the YN, the federal Natural Resources Conservation Service (NRCS), the US Fish and Wildlife Service (USFWS), the National Marine Fisheries Service (NMFS), and US Army Corps of Engineers (COE). Achievements of YTAHP with BPA Action Plan funding during FY 2002 were to: (1) Establish contracts with RC&D and YTAHP participants. (2) Determine contract mechanism for MWH engineering services. (3) Provide engineering designs and services for 11 early action projects, including inverted siphons, pump and gravity diversion screening, diversion metering, rock weirs for improved fish passage

  4. Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors.

    PubMed

    Parashar, Vijay; Jeffrey, Philip D; Neiditch, Matthew B

    2013-01-01

    The large family of Gram-positive quorum-sensing receptors known as the RNPP proteins consists of receptors homologous to the Rap, NprR, PlcR, and PrgX proteins that are regulated by imported oligopeptide autoinducers. Rap proteins are phosphatases and transcriptional anti-activators, and NprR, PlcR, and PrgX proteins are DNA binding transcription factors. Despite their obvious importance, the mechanistic basis of oligopeptide receptor regulation is largely unknown. Here, we report the X-ray crystal structure of the Bacillus subtilis quorum-sensing receptor RapJ in complex with the centrally important oligopeptide autoinducer competence and sporulation factor (CSF, also termed PhrC), a member of the Phr family of quorum-sensing signals. Furthermore, we present the crystal structure of RapI. Comparison of the RapJ-PhrC, RapI, RapH-Spo0F, and RapF-ComA(C) crystal structures reveals the mechanistic basis of Phr activity. More specifically, when complexed with target proteins, Rap proteins consist of a C-terminal tetratricopeptide repeat (TPR) domain connected by a flexible helix-containing linker to an N-terminal 3-helix bundle. In the absence of a target protein or regulatory peptide, the Rap protein 3-helix bundle adopts different conformations. However, in the peptide-bound conformation, the Rap protein N-terminal 3-helix bundle and linker undergo a radical conformational change, form TPR-like folds, and merge with the existing C-terminal TPR domain. To our knowledge, this is the first example of conformational change-induced repeat domain expansion. Furthermore, upon Phr binding, the entire Rap protein is compressed along the TPR superhelical axis, generating new intramolecular contacts that lock the Rap protein in an inactive state. The fact that Rap proteins are conformationally flexible is surprising considering that it is accepted dogma that TPR proteins do not undergo large conformational changes. Repeat proteins are widely used as scaffolds for the

  5. Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.

    PubMed

    Jossin, Yves; Cooper, Jonathan A

    2011-06-01

    Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipolar neurons to polarize their migration toward the cortical plate. Inhibition and rescue experiments indicated that Reelin regulates migration through Rap1 and Akt, and that the Rap1-regulated GTPases RalA, RalB, Rac1 and Cdc42 are also involved. We found that Rap1 regulated the plasma membrane localization of NCad and NCad rescued radial polarization when Rap1 was inhibited. However, inhibition of Rap1 or NCad had little effect on glia-dependent locomotion. We propose a multistep mechanism in which Reelin activates Rap1, Rap1 upregulates NCad, and NCad is needed to orient cell migration.

  6. Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols.

    PubMed

    Bastianetto, S; Krantic, S; Chabot, J-G; Quirion, R

    2011-08-01

    One of the hallmarks of Alzheimer's disease is the accumulation of senile plaques composed of extra-cellular aggregates of beta-amyloid (Aβ) peptides. It is well established that at least in vitro, Aβ triggers apoptotic cell death via the activation of caspase-dependent and -independent cell death effectors, namely caspase-3 and apoptosis inducing factor (AIF), respectively. Epidemiological studies have reported that elderly people have a lower risk (up to 50%) of developing dementia if they regularly eat fruits and vegetables and drink tea and red wine (in moderation). Numerous studies indicate that polyphenols derived from these foods and beverages account for the observed neuroprotective effects. In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Aβ-induced hippocampal cell death, by at least partially inhibiting Aβ fibrillisation. It has been shown that polyphenols may also modulate caspase-dependent and -independent programmed cell death (PCD) pathways. Indeed, polyphenols including resveratrol, EGCG and luteolin significantly inhibit the activation of the key apoptotic executioner, caspase-3 and are able to modulate mitogen-activated protein kinases known to play an important role in neuronal apoptosis. Moreover, it has been reported that polyphenols may exert their anti-apoptotic action by inhibiting AIF release from mitochondria, thus providing new mechanism of action for polyphenols. This review aims to update the current knowledge regarding the differential effects of polyphenols on PCD pathways and discuss their putative neuroprotective action resulting from their capacity to modulate these pathways.

  7. Establishing a regulatory framework for a RCRA (Resource, Conservation, and Recovery Act) corrective action program

    SciTech Connect

    Krueger, J.W.

    1989-01-01

    Recently, the environmental community has become keenly aware of problems associated with integration of the demanding regulations that apply to environmental restoration activities. One can not attend an EPA-sponsored conference on Superfund without distracting questions concerning the Resource, Conservation, and Recovery Act (RCRA) and the applicability of the National Contingency Plan (NCP) to sites that do not qualify for the National Priorities List (NPL). In particular, the US Department of Energy (DOE) has been greatly criticized for its inability to define a comprehensive approach for cleaning up its hazardous waste sites. This article presents two decision flowcharts designed to resolve some of this confusion for DOE. The RCRA/CERCLA Integration Diagram can help the environmental manager determine which law applies and under what conditions, and the RCRA Corrective Action Decision Flowchart can guide the manager in determining which specific sections of RCRA apply to a RCRA-lead environmental restoration program. 13 refs.

  8. Developing internet-based eHealth promotion programs: the Spiral Technology Action Research (STAR) model.

    PubMed

    Skinner, Harvey A; Maley, Oonagh; Norman, Cameron D

    2006-10-01

    Health education and health promotion have a tradition of using information and communication technology (ICT). In recent years, the rapid growth of the Internet has created innovative opportunities for Web-based health education and behavior change applications-termed eHealth promotion. However, many eHealth promotion applications are developed without an explicit model to guide the design, evaluation, and ongoing improvement of the program. The spiral technology action research (STAR) model was developed to address this need. The model comprises five cycles (listen, plan, do, study, act) that weave together technological development, community involvement, and continuous improvement. The model is illustrated by a case study describing the development of the Smoking Zine (www.SmokingZine.org), a youth smoking prevention and cessation Web site.

  9. Effects of the Positive Action Program on Indicators of Positive Youth Development Among Urban Youth.

    PubMed

    Lewis, Kendra M; Vuchinich, Samuel; Ji, Peter; DuBois, David L; Acock, Alan; Bavarian, Niloofar; Day, Joseph; Silverthorn, Naida; Flay, Brian R

    This study evaluated effects of Positive Action, a school-based social-emotional and character development (SECD) intervention, on indicators of positive youth development (PYD) among a sample of low-income, ethnic minority youth attending 14 urban schools. The study used a matched-pair, cluster-randomized controlled design at the school level. A multiple-measure self-report protocol assessed four key strengths and resources for PYD: self-concept, peer affiliations, ethics, and social skills. Students (n=1170) were assessed from grades 3 to 8, the duration of the intervention, with drop-outs and late entrants included in analyses. Growth curve analyses revealed evidence of favorable program effects on each of the four types of resources. The study contributes to PYD research by providing evidence for school-based interventions in low-income, urban contexts for ethnic minority youth.

  10. Effects of the Positive Action Program on Indicators of Positive Youth Development Among Urban Youth

    PubMed Central

    Lewis, Kendra M.; Vuchinich, Samuel; Ji, Peter; DuBois, David L.; Acock, Alan; Bavarian, Niloofar; Day, Joseph; Silverthorn, Naida; Flay, Brian R.

    2015-01-01

    This study evaluated effects of Positive Action, a school-based social-emotional and character development (SECD) intervention, on indicators of positive youth development (PYD) among a sample of low-income, ethnic minority youth attending 14 urban schools. The study used a matched-pair, cluster-randomized controlled design at the school level. A multiple-measure self-report protocol assessed four key strengths and resources for PYD: self-concept, peer affiliations, ethics, and social skills. Students (n=1170) were assessed from grades 3 to 8, the duration of the intervention, with drop-outs and late entrants included in analyses. Growth curve analyses revealed evidence of favorable program effects on each of the four types of resources. The study contributes to PYD research by providing evidence for school-based interventions in low-income, urban contexts for ethnic minority youth. PMID:26941548

  11. Overview of the U.S. Department of Energy Formerly Utilized Sites Remedial Action Program - 12189

    SciTech Connect

    Clayton, Christopher; Kothari, Vijendra; Starr, Ken; Gillespie, Joey; Widdop, Michael; none,

    2012-02-26

    The U.S. Department of Energy (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to address residual radiological contamination at sites where work was performed for the Manhattan Engineer District and U.S. Atomic Energy Commission. Initially, FUSRAP activities began with a records search for sites that had the potential to contain residual radiological contamination; 46 sites were identified that were eligible for and required remediation. Remedial action began in 1979. In 1997, Congress assigned responsibility for the remediation of FUSRAP sites to the U.S. Army Corps of Engineers (USACE). DOE retains responsibility for determining if sites are eligible for FUSRAP remediation and for providing long-term surveillance and maintenance (LTS&M) of remediated FUSRAP sites. DOE LTS&M activities are designed to ensure that FUSRAP sites remain protective of human health and the environment and to preserve knowledge regarding FUSRAP sites. Additional elements include eligibility determinations, transition of remediated sites from USACE to DOE, LTS&M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close coordination with USACE and regulators to ensure there is no loss of protectiveness when sites transition to DOE for LTS&M.

  12. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.

    PubMed

    Lee, Kea Joo; Lee, Yeunkum; Rozeboom, Aaron; Lee, Ji-Yun; Udagawa, Noriko; Hoe, Hyang-Sook; Pak, Daniel T S

    2011-03-10

    Ras and Rap small GTPases are important for synaptic plasticity and memory. However, their roles in homeostatic plasticity are unknown. Here, we report that polo-like kinase 2 (Plk2), a homeostatic suppressor of overexcitation, governs the activity of Ras and Rap via coordination of their regulatory proteins. Plk2 directs elimination of Ras activator RasGRF1 and Rap inhibitor SPAR via phosphorylation-dependent ubiquitin-proteasome degradation. Conversely, Plk2 phosphorylation stimulates Ras inhibitor SynGAP and Rap activator PDZGEF1. These Ras/Rap regulators perform complementary functions to downregulate dendritic spines and AMPA receptors following elevated activity, and their collective regulation by Plk2 profoundly stimulates Rap and suppresses Ras. Furthermore, perturbation of Plk2 disrupts Ras and Rap signaling, prevents homeostatic shrinkage and loss of dendritic spines, and impairs proper memory formation. Our study demonstrates a critical role of Plk2 in the synchronized tuning of Ras and Rap and underscores the functional importance of this regulation in homeostatic synaptic plasticity.

  13. CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.

    PubMed

    Mak, Grace Wing-Yan; Lai, Wai-Lung; Zhou, Yuan; Li, Mingtao; Ng, Irene Oi-Lin; Ching, Yick-Pang

    2012-01-01

    CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. However, it remains unclear if there are other mechanisms by which CDK5RAP3 promotes HCC metastasis. Here, we showed that in CDK5RAP3 stable knockdown SMMC-7721 HCC cells, p14(ARF) tumor suppressor was upregulated at protein and mRNA levels, and ectopic expression of CDK5RAP3 was found to repress the transcription of p14(ARF). Using chromatin immunoprecipitation assay, we demonstrated that CDK5RAP3 bound to p14(ARF) promoter in vivo. Furthermore, knockdown of p14(ARF) in CDK5RAP3 stable knockdown HCC cells reversed the suppression of HCC cell invasiveness mediated by knockdown of CDK5RAP3. Taken together, our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF).

  14. CDK5RAP3 Is a Novel Repressor of p14ARF in Hepatocellular Carcinoma Cells

    PubMed Central

    Mak, Grace Wing-Yan; Li, Mingtao; Ng, Irene Oi-Lin; Ching, Yick-Pang

    2012-01-01

    CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. However, it remains unclear if there are other mechanisms by which CDK5RAP3 promotes HCC metastasis. Here, we showed that in CDK5RAP3 stable knockdown SMMC-7721 HCC cells, p14ARF tumor suppressor was upregulated at protein and mRNA levels, and ectopic expression of CDK5RAP3 was found to repress the transcription of p14ARF. Using chromatin immunoprecipitation assay, we demonstrated that CDK5RAP3 bound to p14ARF promoter in vivo. Furthermore, knockdown of p14ARF in CDK5RAP3 stable knockdown HCC cells reversed the suppression of HCC cell invasiveness mediated by knockdown of CDK5RAP3. Taken together, our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14ARF. PMID:22860085

  15. Affiliation and Alienation: Hip-Hop, Rap, and Urban Science Education

    ERIC Educational Resources Information Center

    Emdin, Christopher

    2010-01-01

    The critiques of rap artists and other participants in hip-hop culture provide data for teachers and researchers to investigate the attitudes of US urban youth towards schooling. This study explores the complex relationships between hip-hop and science education by examining how rap lyrics project beliefs about schooling, the relevance of existing…

  16. Ethnic Identity, Self-Esteem and Variability in Perceptions of Rap Music's Empowering and Risky Influences

    ERIC Educational Resources Information Center

    Travis, Raphael; Bowman, Scott W.

    2012-01-01

    Violence, risky sexual behaviors, and substance use are critical targets for improved health behavior. Prior research has linked levels of exposure to rap music with a range of undesirable health behaviors. Contemporary research has also found health-enhancing and other "positive" correlations with rap music exposure. The present study examined…

  17. 40 CFR 270.85 - When do I need a RAP?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false When do I need a RAP? 270.85 Section 270.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED...) General Information § 270.85 When do I need a RAP? (a) Whenever you treat, store, or dispose of...

  18. Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.

    PubMed

    Maddala, Rupalatha; Nagendran, Tharkika; Lang, Richard A; Morozov, Alexei; Rao, Ponugoti V

    2015-10-01

    Rap1, a Ras-like small GTPase, plays a crucial role in cell-matrix adhesive interactions, cell-cell junction formation, cell polarity and migration. The role of Rap1 in vertebrate organ development and tissue architecture, however, remains elusive. We addressed this question in a mouse lens model system using a conditional gene targeting approach. While individual germline deficiency of either Rap1a or Rap1b did not cause overt defects in mouse lens, conditional double deficiency (Rap1 cKO) prior to lens placode formation led to an ocular phenotype including microphthalmia and lens opacification in embryonic mice. The embryonic Rap1 cKO mouse lens exhibited striking defects including loss of E-cadherin- and ZO-1-based cell-cell junctions, disruption of paxillin and β1-integrin-based cell adhesive interactions along with abnormalities in cell shape and apical-basal polarity of epithelium. These epithelial changes were accompanied by increased levels of α-smooth muscle actin, vimentin and N-cadherin, and expression of transcriptional suppressors of E-cadherin (Snai1, Slug and Zeb2), and a mesenchymal metabolic protein (Dihydropyrimidine dehydrogenase). Additionally, while lens differentiation was not overtly affected, increased apoptosis and dysregulated cell cycle progression were noted in epithelium and fibers in Rap1 cKO mice. Collectively these observations uncover a requirement for Rap1 in maintenance of lens epithelial phenotype and morphogenesis.

  19. The Boisterous Beauty of the Urban Bard: Houston Baker Crusades for the Cultural Relevance of Rap.

    ERIC Educational Resources Information Center

    Wiley, Ed, III

    1993-01-01

    Examines Houston Baker's argument for rap music's place in academe. Baker suggests rap as being one of the most creative and productive forms of cultural expression to come along in some time warranting the same kind of scholarly attention afforded the works of history's most noted philosophers and poets. (GLR)

  20. Black Studies, Rap and the Academy. Black Literature and Culture Series.

    ERIC Educational Resources Information Center

    Baker, Houston A., Jr.

    The relationships among Black Studies as an intellectual discipline and rap music are explored. It is argued that black urban culture has provided much of the impetus for Black Studies, and that the academy and those involved in the black studies discipline should feel a responsibility to take rap music seriously as the expression of urban youth,…

  1. Whats the Rap about Ecstasy? Popular Music Lyrics and Drug Trends among American Youth

    ERIC Educational Resources Information Center

    Diamond, Sarah; Bermudez, Rey; Schensul, Jean

    2006-01-01

    Trends in ecstasy use in America during the past decade were reflected in mainstream, American rap-music lyrics between 1996 and 2003. Drawing on communication and cultural studies theory, this article provides a content analysis of 69 rap songs mentioning the club drug ecstasy. The songs are coded according to whether they contain positive, mixed…

  2. Spiral Development in Action: A Case Study of Spiral Development in the Global Hawk Unmanned Aerial Vehicle Program

    DTIC Science & Technology

    2005-12-01

    government acquisitions, and presented lessons learned through a case study of the Global Hawk UAV Program. This paper examined the Global Hawk’s spiral...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT Spiral Development in Action: A Case Study of Spiral...Professional Report 4. TITLE AND SUBTITLE: Spiral Development in Action: A Case Study of Spiral Development in the Global Hawk Unmanned Aerial

  3. Nuclear facility decommissioning and site remedial actions: A selected bibliography, Volume 13: Part 1, Main text. Environmental Restoration Program

    SciTech Connect

    Goins, L.F.; Webb, J.R.; Cravens, C.D.; Mallory, P.K.

    1992-09-01

    This publication contains 1035 abstracted references on environmental restoration, nuclear facility decommissioning, uranium mill tailings management, and site remedial actions. These citations constitute the thirteenth in a series of reports prepared annually for the US Department of Energy (DOE) Environmental Restoration programs. Citations to foreign and domestic literature of all types. There are 13 major sections of the publication, including: (1) DOE Decontamination and Decommissioning Program; (2) Nuclear Facilities Decommissioning; (3) DOE Formerly Utilized Sites Remedial Action Program; (4) DOE Uranium Mill Tailings Remedial Action Project; (5) Uranium Mill Tailings Management; (6) DOE Environmental Restoration Program; (7) DOE Site-Specific Remedial Actions; (8) Contaminated Site Restoration; (9) Remediation of Contaminated Soil and Groundwater; (10) Environmental Data Measurements, Management, and Evaluation; (11) Remedial Action Assessment and Decision-Making; (12) Technology Development and Evaluation; and (13) Environmental and Waste Management Issues. Bibliographic references are arranged in nine subject categories by geographic location and then alphabetically by first author, corporate affiliation, or publication title. Indexes are provided for author, corporate affiliation, title word, publication description, geographic location, subject category, and key word.

  4. Remedial action plan and site design for stabilization of the inactive uranium mill tailings site at Tuba City, Arizona. [Uranium Mill Tailings Remedial Action (UMTRA) Project

    SciTech Connect

    Not Available

    1987-05-01

    This appendix assesses the present conditions and data for the inactive uranium mill site near Tuba City, Arizona. It consolidates available engineering, radiological, geotechnical, hydrological, meterological, and other information pertinent to the design of the Remedial Action Plan (RAP). The data characterize conditions at the mill and tailings site so that the Remedial Action Contractor (RAC) may complete final designs of the remedial actions.

  5. Literacy in Action: A Carbon-Neutral Field Program at Cornell University

    NASA Astrophysics Data System (ADS)

    Moore, A.; Derry, L.

    2010-12-01

    The Cornell Earth and Environmental Systems (EES) Field Program is a semester-length undergraduate field program located on the island of Hawai`i. The Hawaiian Islands are the world’s most dynamic natural laboratory and the premier location for Earth systems research and education. While there are compelling reasons for students and faculty to travel from the US mainland to Hawai`i, the air and ground travel that comprises the program carries a large carbon footprint. This liability is also an extraordinary educational opportunity. For the past two years EES students have been challenged to make the program carbon-neutral. They are asked to devise a set of criteria for a credible and defensible zero-CO2 footprint and then to put their plan into action. The C-neutral project consists of three elements: (1) quantifying CO2 emissions, (2) reducing emissions wherever possible, and (3) offsetting emissions that cannot be eliminated. In quantifying emissions six areas are identified: air travel, ground travel, domestic electricity, natural gas, food, and waste. Emissions reductions include all of the standard “carpool--turn it down--turn it off “ conservation behaviors, with special emphasis on food and waste; eating local and organic, shopping at re-use centers, and compost and recycling of garbage. Our program facility utilizes solar hot water and is equipped with neither heat nor air conditioning, thus domestic energy use is low. Students tabulate all of our energy use and calculate the resulting CO2 emissions for all program participants for a period of four months. The CO2 offsetting strategy is conducted in collaboration with a native ecosystem restoration project. Students participate in all aspects of forest restoration, including seed collection, germination and outplanting of native plant species and removal of invasive pest species. The initial goal of this locally-supported project was to restore degraded pasture to native forest. The EES students have

  6. 40 CFR 270.230 - May I perform remediation waste management activities under a RAP at a location removed from the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... management activities under a RAP at a location removed from the area where the remediation wastes originated... Plans (RAPs) Obtaining A Rap for An Off-Site Location § 270.230 May I perform remediation waste management activities under a RAP at a location removed from the area where the remediation wastes...

  7. 40 CFR 270.230 - May I perform remediation waste management activities under a RAP at a location removed from the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... management activities under a RAP at a location removed from the area where the remediation wastes originated... Plans (RAPs) Obtaining A Rap for An Off-Site Location § 270.230 May I perform remediation waste management activities under a RAP at a location removed from the area where the remediation wastes...

  8. Give Water a Hand. Leader Guidebook. Youth Action Program. Promoting Good Water Management Practices at Home and in the Community.

    ERIC Educational Resources Information Center

    Wisconsin Univ., Madison. Coll. of Agricultural and Life Sciences.

    Educators of students grades 4-8 can use this guide to lead a community service project using the "Give Water a Hand" youth action program. Youth groups investigate water and water conservation within the home, farm, ranch, school, or community, with the help of local experts. The guide contains six chapters that cover: (1) an…

  9. A Comprehensive Evaluation of OEO Community Action Programs on Six Selected American Indian Reservations. Report 4 - Final Report.

    ERIC Educational Resources Information Center

    Smith, James G. E.; And Others

    The impact of the Office of Economic Opportunity (OEO) Community Action Programs (CAP) on 6 selected American Indian reservations (Gila River and Papago, Arizona; Santa Clara Pueblo, New Mexico; Pine Ridge, South Dakota; Turtle Mountain, North Dakota, and White Earth Chippewa, Minnesota) are evaluated. After considering the development of Indian…

  10. Annual Report on Wildlife Activities, 1985 Fiscal Year, Action Item 40.1, Columbia River Basin Fish and Wildlife Program.

    SciTech Connect

    United States. Bonneville Power Administration.

    1985-09-01

    The report presents a brief synopsis and discussion of wildlife activities undertaken by Bonneville Power Administration. The objectives of the program were wildlife protection, mitigation, and enhancement planning; and implementation of actions to protect, mitigate, and enhance wildlife affected by development and operation of hydroelectric facilities in the Columbia River Basin. (ACR)

  11. Photovoice as Participatory Action Research Tool for Engaging People with Intellectual Disabilities in Research and Program Development

    ERIC Educational Resources Information Center

    Jurkowski, Janine M.

    2008-01-01

    People with intellectual disabilities have few opportunities to actively participate in research affecting programs and policies. Employment of participatory action research has been recommended. Although use of this approach with people who have intellectual disabilities is growing, articles on specific participatory research methods are rare.…

  12. How Do Pre-Service Teachers Cope with a Literacy Intervention Program in a Remote Indigenous Community? The Community Action Support Program in the Northern Territory, Australia

    ERIC Educational Resources Information Center

    Naidoo, Loshini

    2012-01-01

    This paper examines a new community education initiative, Community Action Support (CAS) that helps facilitate learning in Indigenous young people from Tennant Creek in the Northern Territory. CAS is an innovative partnership program between the Australian Literacy and Numeracy Foundation and the University of Western Sydney. The core aim of the…

  13. Characterization of low-temperature properties of plant-produced rap mixtures in the Northeast

    NASA Astrophysics Data System (ADS)

    Medeiros, Marcelo S., Junior

    The dissertation outlined herein results from a Federal Highway Administration sponsored project intended to investigate the impacts of high percentages of RAP material in the performance of pavements under cold climate conditions. It is comprised of two main sections that were incorporated into the body of this dissertation as Part I and Part II. In Part I a reduced testing framework for analysis of HMA mixes was proposed to replace the IDT creep compliance and strength testing by dynamic modulus and fatigue tests performed on an AMPT device. A continuum damage model that incorporates the nonlinear constitutive behavior of the HMA mixtures was also successfully implemented and validated. Mixtures with varying percentages of reclaimed material (RAP) ranging from 0 to 40% were used in this research effort in order to verify the applicability of the proposed methodology to RAP mixtures. Part II is concerned with evaluating the effects of various binder grades on the properties of plant-produced mixtures with various percentages of RAP. The effects of RAP on mechanical and rheological properties of mixtures and extracted binders were studied in order to identify some of the deficiencies in the current production methodologies. The results of this dissertation will help practitioners to identify optimal RAP usage from a material property perspective. It also establishes some guidelines and best practices for the use of higher RAP percentages in HMA.

  14. KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression

    PubMed Central

    Ahmed, Syed M.; Thériault, Brigitte L.; Uppalapati, Maruti; Chiu, Catherine W.N.; Gallie, Brenda L.; Sidhu, Sachdev S.

    2012-01-01

    The small GTPase Rap1 regulates inside-out integrin activation and thereby influences cell adhesion, migration, and polarity. Several Rap1 effectors have been described to mediate the cellular effects of Rap1 in a context-dependent manner. Radil is emerging as an important Rap effector implicated in cell spreading and migration, but the molecular mechanisms underlying its functions are unclear. We report here that the kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules. The depletion of KIF14 led to increased cell spreading, altered focal adhesion dynamics, and inhibition of cell migration and invasion. We also show that Radil is important for breast cancer cell proliferation and for metastasis in mice. Our findings provide evidence that the concurrent up-regulation of Rap1 activity and increased KIF14 levels in several cancers is needed to reach optimal levels of Rap1–Radil signaling, integrin activation, and cell–matrix adhesiveness required for tumor progression. PMID:23209302

  15. Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice

    PubMed Central

    Kraus, Anna E.; Gale, Daniel; White, Gilbert C.; VanSluys, Jillian

    2008-01-01

    Angiogenesis is the main mechanism of vascular remodeling during late development and, after birth, in wound healing. Perturbations of angiogenesis occur in cancer, diabetes, ischemia, and inflammation. While much progress has been made in identifying factors that control angiogenesis, the understanding of the precise molecular mechanisms involved is incomplete. Here we identify a small GTPase, Rap1b, as a positive regulator of angiogenesis. Rap1b-deficient mice had a decreased level of Matrigel plug and neonatal retinal neovascularization, and aortas isolated from Rap1b-deficient animals had a reduced microvessel sprouting response to 2 major physiological regulators of angiogenesis: vascular endothelial growth factor (VEGF) and basic fibroblasts growth factor (bFGF), indicating an intrinsic defect in endothelial cells. Proliferation of retinal endothelial cells in situ and in vitro migration of lung endothelial cells isolated from Rap1b-deficient mice were inhibited. At the molecular level, activation of 2 MAP kinases, p38 MAPK and p42/44 ERK, important regulators of endothelial migration and proliferation, was decreased in Rap1b-deficient endothelial cells in response to VEGF stimulation. These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells. PMID:17993608

  16. Rap1 and its effector RIAM are required for lymphocyte trafficking.

    PubMed

    Su, Wenjuan; Wynne, Joseph; Pinheiro, Elaine M; Strazza, Marianne; Mor, Adam; Montenont, Emilie; Berger, Jeffrey; Paul, David S; Bergmeier, Wolfgang; Gertler, Frank B; Philips, Mark R

    2015-12-17

    Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM). Using mice conditionally deficient in both Rap1a and Rap1b and mice null for RIAM, we show that the Rap1/RIAM module is not required for T- or B-cell development but is essential for efficient adhesion to intercellular adhesion molecule (ICAM) 1 and vascular cell adhesion molecule (VCAM) 1 and for proper trafficking of lymphocytes to secondary lymphoid organs. Interestingly, in RIAM-deficient mice, whereas peripheral lymph nodes (pLNs) were depleted of both B and T cells and recirculating B cells were diminished in the bone barrow (BM), the spleen was hypercellular, albeit with a relative deficiency of marginal zone B cells. The abnormality in lymphocyte trafficking was accompanied by defective humoral immunity to T-cell-dependent antigens. Platelet function was intact in RIAM-deficient animals. These in vivo results confirm a role for RIAM in the regulation of some, but not all, leukocyte integrins and suggest that RIAM-regulated integrin activation is required for trafficking of lymphocytes from blood into pLNs and BM, where relatively high shear forces exist in high endothelial venules and sinusoids, respectively.

  17. Determination of ecologically vital groundwaters at selected sites in the Formerly Utilized Sites Remedial Action Program

    SciTech Connect

    Vinikour, W.S.; Yin, S.C.L.

    1989-08-01

    The US Department of Energy is classifying groundwaters at sites in its Formerly Utilized Sites Remedial Action Program (FUSRAP). Of particular concern is the potential presence of groundwaters that are highly vulnerable to contamination and that are either (1) irreplaceable sources of drinking water or (2) ecologically vital. Conditions at nine FUSRAP sites were evaluated to determine if ecologically vital groundwaters are present. The sites evaluated were Wayne Interim Storage Site, Maywood Interim Storage Site, and Middlesex Sampling Plant in New Jersey; Ashland 2 Site, Seaway Industrial Park, Colonie Interim storage Site, and Niagara Falls Storage Site in New York; and the St. Louis Airport Site and Hazelwood Interim Storage Site in Missouri. The analyses indicated that groundwaters are vulnerable to contamination at all but two of the sites -- the Ashland 2 and Seaway Industrial Park sites in New York. Groundwater discharge points were identified within a 2-mile radius (i.e., the classification review area) of all of the sites. No ecologically vital groundwater areas exist in the vicinities of any of the nine FUSRAP sites evaluated. 35 refs., 17 figs.

  18. An Action Dependent Heuristic Dynamic Programming-controlled Superconducting Magnetic Energy Storage for Transient Stability Augmentation

    NASA Astrophysics Data System (ADS)

    Wang, Xinpu; Yang, Jun; Zhang, Xiaodong; Yu, Xiaopeng

    To enhance the stability of power system, the active power and reactive power can be absorbed from or released to Superconducting magnetic energy storage (SMES) unit according to system power requirements. This paper proposes a control strategy based on action dependent heuristic dynamic programing (ADHDP) which can control SMES to improve the stability of electric power system with on-line learning ability. Based on back propagation (BP) neural network, ADHDP approximates the optimal control solution of nonlinear system through iteration step by step. This on-line learning ability improves its performance by learning from its own mistakes through reinforcement signal from external environment, so that it can adjust the neural network weights according to the back propagation error to achieve optimal control performance. To investigate the effectiveness of the proposed control strategy, simulation tests are carried out in Matlab/Simulink. And a conventional Proportional-Integral (PI) controlled method is used to compare the performance of ADHDP. Simulation results show that the proposed controller demonstrates superior damping performance on power system oscillation caused by three-phase fault and wind power fluctuation over the PI controller.

  19. Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay.

    PubMed

    Gu, Liubao; Kitamura, Masanori

    2012-01-01

    Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses. However, the profile of secreted proteins in SASP is different from cell type to cell type, and currently, universal markers for SASP have not been reported. In the present investigation, we show that SASP-responsive alkaline phosphatase (SASP-RAP) serves as a sensitive, general and convenient marker for SASP. Etoposide-treated cells exhibited a senescent phenotype characterized by senile morphology, positive staining for senescence-associated β-galactosidase, growth arrest and induction of p53 and p21(WAF1/CIP1). In SASP-RAP-transfected cells, exposure to etoposide increased secretion of SASP-RAP time-dependently. The kinetics of secretion was closely correlated with that of activation of the p21(WAF1/CIP1) promoter and the p16(INK4a) promoter. The enhanced secretion of SASP-RAP by senescence was also observed in cells treated with other senescence inducers such as trichostatin A, doxorubicin and 4-phenylbutylic acid. The induction of SASP-RAP by senescence was similarly observed in natural replicative senescence. To confirm selectivity of the SASP-RAP response, cells were treated with senescence-related and -unrelated stimuli (IL-1β, LPS, TNF-α and TGF-β), and induction of senescence markers and activity of SASP-RAP were evaluated in parallel. Unlike etoposide, senescence-unrelated stimuli did not induce p53 and p21(WAF1/CIP1), and it was correlated with lack of induction of SASP-RAP. In contrast, senescence-unrelated stimuli up-regulated conventional indicators for SASP, e.g., MMP-3, IL-6 and TIMP, without induction of senescence. SASP-RAP thus serves as a selective, convenient and general marker for detection and monitoring of SASP during cellular senescence.

  20. Ultrastructural localization of the small GTP-binding protein Rap1 in human platelets and megakaryocytes.

    PubMed

    Berger, G; Quarck, R; Tenza, D; Levy-Toledano, S; de Gunzburg, J; Cramer, E M

    1994-10-01

    Several functions have been proposed for Rap1B in human platelets, including the regulation of phospholipase (PL) C gamma and Ca2+ ATPase. However, its localization is largely unknown. In the present study we have investigated the subcellular distribution of Rap1 by immunocytochemical techniques using affinity purified polyclonal antibodies raised against residues 121-137 common to the 95% homologous Rap1A and Rap1B proteins. By immunofluorescence, a positive labelling was obtained on intact resting platelets and was abolished after adsorption of the antibodies with the control peptide. Immunoelectron microscopy was then used to further define the subcellular localization of Rap1B in platelets and megakaryocytes (MK). In resting cells, immunolabelling for Rap1B was associated with the plasma membrane, mostly at its inner face, and lined the membrane of the open canalicular system (OCS). Some labelling was also found outlining the alpha-granules, identified as such by a double labelling with an anti-GPIIb-IIIa. On thrombasthenic platelets the same localization was observed. When platelets were stimulated by thrombin, immunolabelling for Rap1B was redistributed to the zones of fusion of the granules with the OCS, and to the plasma membrane with a higher concentration on pseudopods. Human MK expressed Rap1 and the staining revealed the association of the protein with the demarcation membranes and alpha-granules. This study presents a first approach to the localization of a small GTP binding-protein Rap1B in whole platelets and MK, and shows its association with both the plasma and OCS membranes, as well as with the alpha-granule membranes.