40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.16 - Waiver.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Waiver. 121.16 Section 121.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121.16 Waiver. The...

40 CFR 121.16 - Waiver.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Waiver. 121.16 Section 121.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121.16 Waiver. The...

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.16 - Waiver.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Waiver. 121.16 Section 121.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121.16 Waiver. The...

40 CFR 121.12 - Supplemental information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Supplemental information. 121.12 Section 121.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121...

40 CFR 121.16 - Waiver.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Waiver. 121.16 Section 121.16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121.16 Waiver. The...

The U.S. Environmental Protection Industry: A Proposed Framework for Assessment (1995)

EPA Pesticide Factsheets

This study defines which goods and services are used for environmental protection activities in the United States. Direct and indirect value added and employment associated with environmental protection activities are calculated for 1977, 1982, 1985, 1988,

40 CFR 35.925-16 - Federal activities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Federal activities. 35.925-16 Section 35.925-16 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.925-16...

40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Lead-based paint activities: State and...

40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Lead-based paint activities: State and...

40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Lead-based paint activities: State and...

40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Lead-based paint activities: State and...

40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Lead-based paint activities: State and...

40 CFR 121.11 - Copies of documents.

Code of Federal Regulations, 2014 CFR

2014-07-01

....11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121... relate to water quality considerations shall be forwarded to the Regional Administrator. ...

Data with a Mission: Building a Community for Interactive Data Visualization at the U.S. Environmental Protection Agency

EPA Science Inventory

The U.S Environmental Protection Agency’s (EPA) stated mission is to protect human health and the environment. A big part of our activities directed at fulfilling our mission directly involve using data. Environmental analysis, activity planning and communication are just a few o...

40 CFR 121.11 - Copies of documents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 121.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121... relate to water quality considerations shall be forwarded to the Regional Administrator. ...

40 CFR 121.11 - Copies of documents.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 121.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121... relate to water quality considerations shall be forwarded to the Regional Administrator. ...

40 CFR 121.11 - Copies of documents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 121.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121... relate to water quality considerations shall be forwarded to the Regional Administrator. ...

40 CFR 121.11 - Copies of documents.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 121.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on Other States § 121... relate to water quality considerations shall be forwarded to the Regional Administrator. ...

30 CFR 219.410 - What does this subpart contain?

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Projects and activities for the purposes of coastal protection, including conservation, coastal restoration, hurricane protection, and infrastructure directly affected by coastal wetland losses. (2) Mitigation of... Gulf producing States); to eligible coastal political subdivisions within those States; and to the Land...

40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 9 2012-07-01 2012-07-01 false How do I monitor the injection rate of activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements fo...

40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 9 2014-07-01 2014-07-01 false How do I monitor the injection rate of activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements fo...

40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 8 2011-07-01 2011-07-01 false How do I monitor the injection rate of activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Federal Plan Requirements fo...

78 FR 5813 - 2013 Assuring Radiation Protection

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-28

...] 2013 Assuring Radiation Protection AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... of the Center for Devices and Radiological Health (CDRH) radiation protection program. The goal of the 2013 Assuring Radiation Protection will be to coordinate Federal, State, and Tribal activities to...

The impact of mining activities on Mongolia's protected areas: a status report with policy recommendations.

PubMed

Farrington, John D

2005-07-01

Mongolia's protected areas cover 20.5 million ha or 13.1% of its national territory. Existing and proposed protected areas, however, are threatened by mining. Mining impacts on Mongolia's protected areas are diverse and include licensed and unlicensed mineral activities in protected areas, buffer zone disturbance, and prevention of the establishment of proposed protected areas. Review of United States, Canadian, and Australian policies revealed 9 basic approaches to resolving conflicts between protected areas and mining. Four approaches suitable for Mongolia are granting land trades and special dispensations in exchange for mineral licenses in protected areas; granting protected status to all lapsed mineral licenses in protected areas; voluntary forfeiting of mineral licenses in protected areas in exchange for positive corporate publicity; and prohibiting all new mineral activities in existing and proposed protected areas. Mining is Mongolia's most important industry, however, and the long-term benefits of preserving Mongolia's natural heritage must be considered and weighed against the economic benefits and costs of mining activities.

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A STATE DEPARTMENT OF TRANSPORTATION.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the State of New Jersey. One of th...

12 CFR 208.81 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE SYSTEM (REGULATION H) Consumer Protection in Sales of Insurance § 208.81 Purpose and scope. This subpart establishes consumer protections in connection with... consumer by: (a) Any state member bank; or (b) Any other person that is engaged in such activities at an...

GEOGRAPHY AND ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

The US Environmental Protection Agency helps state and local governments protect the environment by encouraging good environmental management and by regulating human activities to ensure clean air and water. At the Corvallis research laboratory for the EPA, we improve the ways t...

A quantitative approach to assessing the efficacy of occupant protection programs: A case study from Montana.

PubMed

Manlove, Kezia; Stanley, Laura; Peck, Alyssa

2015-10-01

Quantitative evaluation of vehicle occupant protection programs is critical for ensuring efficient government resource allocation, but few methods exist for conducting evaluation across multiple programs simultaneously. Here we present an analysis of occupant protection efficacy in the state of Montana. This approach relies on seat belt compliance rates as measured by the National Occupant Protection Usage Survey (NOPUS). A hierarchical logistic regression model is used to estimate the impacts of four Montana Department of Transportation (MDT)-funded occupant protection programs used in the state of Montana, following adjustment for a suite of potential confounders. Activity from two programs, Buckle Up coalitions and media campaigns, are associated with increased seat belt use in Montana, whereas the impact of another program, Selective Traffic Enforcement, is potentially masked by other program activity. A final program, Driver's Education, is not associated with any shift in seat belt use. This method allows for a preliminary quantitative estimation of program impacts without requiring states to obtain any new seat belt use data. This approach provides states a preliminary look at program impacts, and a means for carefully planning future program allocation and investigation. Copyright © 2015 Elsevier Ltd. All rights reserved.

Organized and Unstructured Activity Participation among Adolescents Involved with Child Protective Services in the United States

ERIC Educational Resources Information Center

Kwak, Yoonyoung; Lu, Ting; Christ, Sharon L.

2017-01-01

Background: Many adolescents are referred to Child Protective Services for possible maltreatment every year, but not much is known about their organized and unstructured activity participation. Objective: The purposes of this study are to provide a description of organized and unstructured activity participation for adolescents who were possible…

Active measurement-based quantum feedback for preparing and stabilizing superpositions of two cavity photon number states

NASA Astrophysics Data System (ADS)

Berube-Lauziere, Yves

The measurement-based quantum feedback scheme developed and implemented by Haroche and collaborators to actively prepare and stabilize specific photon number states in cavity quantum electrodynamics (CQED) is a milestone achievement in the active protection of quantum states from decoherence. This feat was achieved by injecting, after each weak dispersive measurement of the cavity state via Rydberg atoms serving as cavity sensors, a low average number classical field (coherent state) to steer the cavity towards the targeted number state. This talk will present the generalization of the theory developed for targeting number states in order to prepare and stabilize desired superpositions of two cavity photon number states. Results from realistic simulations taking into account decoherence and imperfections in a CQED set-up will be presented. These demonstrate the validity of the generalized theory and points to the experimental feasibility of preparing and stabilizing such superpositions. This is a further step towards the active protection of more complex quantum states than number states. This work, cast in the context of CQED, is also almost readily applicable to circuit QED. YBL acknowledges financial support from the Institut Quantique through a Canada First Research Excellence Fund.

State and territorial use of ground-water strategy grant funds (Section 106 Clean Water Act). Technical report (Final)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-05-01

This document reports on the activities of States in FY 85 and 86 in developing and implementing State ground-water protection strategies using Clean Water Act Section 106 funds. Every State and all but one territory has participated in the program. Strategies have included emphasis on the need to consolidate State and local agency efforts, and to provide clear policy direction, greater public awareness and education concerning ground-water protection.

The State Role

ERIC Educational Resources Information Center

Callan, Patrick M.; Jonsen, Richard W.

1976-01-01

Reviews higher education consumer protection activities currently undertaken by the states, with suggestions about others that should be implemented and the role that state coordinating agencies can play in them. (Editor/JT)

Solving the problems we face: the United States Environmental Protection Agency, sustainability, and the challenges of the twenty-first century

EPA Science Inventory

Addressing the problems of the twenty-first century will require new initiatives that complement traditional regulatory activities. Existing regulations, such as the Clean Air Act and Clean Water Act are important safety nets in the United States for protecting human health and t...

78 FR 13844 - Change in Submission Requirements for State Mitigation Plans

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-01

... protecting human lives and the environment. No action that FEMA can anticipate under this rule will have a... to reduce damage to lives, property, and the economy from future disasters. State, Tribal, and local... funding for eligible mitigation activities that reduce disaster losses and protect life and property from...

22 CFR 71.5 - Storage or safekeeping of private property.

Code of Federal Regulations, 2010 CFR

2010-04-01

....5 Section 71.5 Foreign Relations DEPARTMENT OF STATE PROTECTION AND WELFARE OF AMERICANS, THEIR PROPERTY AND ESTATES PROTECTION AND WELFARE OF CITIZENS AND THEIR PROPERTY General Activities § 71.5... request, at his own risk, and with full knowledge that neither the Government of the United States nor any...

Notification: Oversight of Superfund State Contracts for Remedial Activities

EPA Pesticide Factsheets

Project #OA-FY15-0054, December 30, 2014. The Office of Inspector General (OIG) for the U.S. Environmental Protection Agency (EPA) is beginning an audit of the EPA's oversight of Superfund State Contracts (SSCs) for remedial activities.

23 CFR 750.104 - Signs that may not be permitted in protected areas.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Signs that may not be permitted in protected areas. 750... permitted in protected areas. Erection or maintenance of the following signs may not be permitted in protected areas: (a) Signs advertising activities that are illegal under State or Federal laws or...

[Industrial ecology problems in the activities of the State Epidemiological Health Surveillance Center in Shchelkovo District, Moscow Province].

PubMed

Poliak, V E

1997-01-01

Thorough work of specialists in occupational hygiene and environment protection enables State Sanitary and Epidemiologic Supervision Departments to better work conditions substantially and to lower harm to environment and public health. State Sanitary and Epidemiologic Supervision Department in Shchelkovo [correction of Shyolkovo] accomplished cessation of some industrial processes polluting environment, resettlement of inhabitants away from expanded zones of sanitary protection, important measures in industrial ecology.

40 CFR 121.13 - Review by Regional Administrator and notification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Review by Regional Administrator and notification. 121.13 Section 121.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on...

40 CFR 121.13 - Review by Regional Administrator and notification.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Review by Regional Administrator and notification. 121.13 Section 121.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on...

40 CFR 121.13 - Review by Regional Administrator and notification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Review by Regional Administrator and notification. 121.13 Section 121.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on...

40 CFR 121.13 - Review by Regional Administrator and notification.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Review by Regional Administrator and notification. 121.13 Section 121.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Determination of Effect on...

78 FR 23280 - Agency Information Collection Activities: United States-Caribbean Basin Trade Partnership Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-18

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Agency Information Collection... Protection (CBP), Department of Homeland Security. ACTION: 60-Day Notice and request for comments; Extension... assured of consideration. ADDRESSES: Direct all written comments to U.S. Customs and Border Protection...

23 CFR 750.104 - Signs that may not be permitted in protected areas.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Advertising Adjacent to the Interstate System Under the 1958 Bonus Program § 750.104 Signs that may not be... protected areas: (a) Signs advertising activities that are illegal under State or Federal laws or regulations in effect at the location of such signs or at the location of such activities. (b) Obsolete signs...

50 CFR 224.104 - Special requirements for fishing activities to protect endangered sea turtles.

Code of Federal Regulations, 2012 CFR

2012-10-01

... activities to protect endangered sea turtles. 224.104 Section 224.104 Wildlife and Fisheries NATIONAL MARINE... endangered sea turtles. (a) Shrimp fishermen in the southeastern United States and the Gulf of Mexico who comply with rules for threatened sea turtles specified in § 223.206 of this chapter will not be subject...

50 CFR 224.104 - Special requirements for fishing activities to protect endangered sea turtles.

Code of Federal Regulations, 2011 CFR

2011-10-01

... activities to protect endangered sea turtles. 224.104 Section 224.104 Wildlife and Fisheries NATIONAL MARINE... endangered sea turtles. (a) Shrimp fishermen in the southeastern United States and the Gulf of Mexico who comply with rules for threatened sea turtles specified in § 223.206 of this chapter will not be subject...

78 FR 23811 - Privacy Act of 1974; Proposed New Routine Uses and System of Records Alterations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

..., and local law enforcement agencies and private security contractors to protect the safety of SSA... respect to activities that affect such safety and security, or activities that disrupt the operation of.... B. To Federal, State, and Local Law Enforcement To Protect the Safety of SSA Employees and Customers...

76 FR 44904 - Agency Information Collection Activities; Proposed Collection; Comment Request; State Water...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2011-0424; FRL-9443-7] Agency Information Collection Activities; Proposed Collection; Comment Request; State Water Quality Program Management Resource Analysis... is planning to submit a request for a new Information Collection Request (ICR) to the Office of...

40 CFR 121.25 - Adoption of new water quality standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Adoption of new water quality standards. 121.25 Section 121.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Certification by the Administrator § 121.25 Adoption of new water...

40 CFR 121.25 - Adoption of new water quality standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Adoption of new water quality standards. 121.25 Section 121.25 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE CERTIFICATION OF ACTIVITIES REQUIRING A FEDERAL LICENSE OR PERMIT Certification by the Administrator § 121.25 Adoption of new water...

40 CFR 35.161 - Definition.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Water Pollution Control (section 106) § 35.161 Definition. Recurrent expenditures are those expenditures associated with the activities of a continuing Water Pollution Control...

40 CFR 35.161 - Definition.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Water Pollution Control (section 106) § 35.161 Definition. Recurrent expenditures are those expenditures associated with the activities of a continuing Water Pollution Control...

Laser Detection of Nanoparticles In the Environment

EPA Science Inventory

The United States Environmental Protection Agency (EPA) is charged by Congress to protect the nation’s natural resources. Under the mandate of national environmental laws, the EPA strives to formulate and implement actions leading to a compatible balance between human activities ...

Performance Assessment of Hearing Protection and Communication Enhancement Devices: Peltor Comtac III and IV

DTIC Science & Technology

2015-07-01

providing a hear-thru, or active capability while mitigating hearing loss and tinnitus caused by exposure to loud, steady-state and impulse noise. Active...loss and tinnitus caused by exposure to loud, steady-state and impulse noise. The general approach was to use ANSI standard measurement procedures

7 CFR 799.7 - Early involvement in private and state and local activities requiring Federal approval.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 7 2014-01-01 2014-01-01 false Early involvement in private and state and local activities requiring Federal approval. 799.7 Section 799.7 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE ENVIRONMENTAL PROTECTION ENVIRONMENTAL...

Sulforaphane is anticonvulsant and improves mitochondrial function.

PubMed

Carrasco-Pozo, Catalina; Tan, Kah Ni; Borges, Karin

2015-12-01

The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal mitochondrial bioenergetics. We found that daily injections of sulforaphane for 5 days elevated the seizure thresholds to 6 Hz stimulation and fluorothyl-, but not pentylenetetrazole-induced tonic seizures and protected mice against pilocarpine-induced status epilepticus (SE). Also, sulforaphane increased the antioxidant defences within hippocampal formations and blood plasma. In addition, sulforaphane treatment reduced the extent of hippocampal lipid peroxidation 24 h post-SE and protected hippocampal mitochondria against SE-induced reduction in state 2 and uncoupler-stimulated state 3 respiration. SE-mediated partial loss of rotenone-sensitive and complex II-driven respiration was reduced, consistent with the enhanced activities of complexes I and II in sulforaphane-treated SE mice. In mitochondria isolated from both no SE and SE mice, sulforaphane increased state 3 respiration and respiration linked to ATP synthesis, which may contribute to its anticonvulsant and antioxidant effects by providing more ATP for cellular vital and protective functions. However, sulforaphane did not prevent SE-induced hippocampal cell death. In conclusion, sulforaphane and/or Nrf2 activation are viable anticonvulsant strategies, which are antioxidant and enhance mitochondrial function, especially the ability to produce ATP. Sulforaphane was anticonvulsant in two acute mouse models of epilepsy and protected mice against pilocarpine-induced status epilepticus (SE). We also found antioxidant effects of sulforaphane in mouse plasma and hippocampal formations, exhibited by increased catalase and superoxide dismutase (SOD) activity, as well as increased abilities of hippocampal mitochondria to produce ATP. These effects likely underlie sulforaphane's anticonvulsant mechanisms of action. © 2015 International Society for Neurochemistry.

Playing Hockey, Riding Motorcycles, and the Ethics of Protection

PubMed Central

2012-01-01

Ice hockey and motorcycle riding are increasingly popular activities in the United States that are associated with high risks of head and facial injuries. In both, effective head and facial protective equipment are available. Yet the debates about safety policies regarding the use of head protection in these activities have taken different forms, in terms of the influence of epidemiological data as well as of the ethical concerns raised. I examine these debates over injury prevention in the context of leisure activities, in which the public health duty to prevent avoidable harm must be balanced with the freedom to assume voluntary risks. PMID:23078472

Ischemia/reperfusion-induced injury of forebrain mitochondria and protection by ascorbate.

PubMed

Sciamanna, M A; Lee, C P

1993-09-01

Complete, reversible forebrain ischemia was induced with a seven-vessel occlusion rat model. Previous studies of ischemic (M. A. Sciamanna, J. Zinkel, A. Y. Fabi, and C. P. Lee, 1992, Biochim. Biophys. Acta 1134, 223-232) rat brain mitochondria (RBM) showed that ischemia of 30 min caused an approximately 60% decrease in State 3 respiratory rates with both succinate and NAD-linked substrates and also in energy-linked Ca2+ transport. No significant change was seen in the State 4 rates. The inhibition of respiration could be prevented by EGTA or ruthenium red. In this paper it is shown that reperfusion (5 h) following ischemia (30 min) further impaired RBM respiratory activities (succinate and NAD-linked substrates). The presence of EGTA or ruthenium red in the assay medium did not protect against ischemia/reperfusion-induced injury. The effects of ascorbate, an oxygen radical scavenger, were studied. RBM isolated from ascorbate-treated animals (0.8 mg ascorbate/kg body weight) after ischemia (30 min) alone showed only a slight increase in State 3 (approximately 25%) and a decrease in State 4 (approximately 20%) activities with succinate, when compared to untreated 30-min ischemic animals, whereas, with glutamate+malate little or no effect was seen. The respiratory activities of RBM from ascorbate-treated, ischemic/reperfused (30 min/5 h) rats were restored to approximately 65% of controls levels. Ascorbate protection was dose-dependent with maximum protection at 0.8 mg ascorbate/kg body weight of rat. The k of succinate oxidase-supported Ca2+ uptake also returned to 62% of control values. Protection by ascorbate was most effective when administered prior to the onset of ischemia and provided partial protection when administered after the onset of reperfusion. These results suggest that ischemia-induced injury is primarily mediated by disruption of cellular Ca2+ homeostasis, and reperfusion-induced injury by peroxidative events.

Implementation Of Conservation Policy Through The Protection Of Life Support System In The Karimunjawa National Park

NASA Astrophysics Data System (ADS)

Ariyani, Nur Anisa Eka; Kismartini

2018-02-01

The Karimunjawa National Park as the only one marine protected area in Central Java, managed by zonation system has decreased natural resources in the form of decreasing mangrove forest area, coral cover, sea biota population such as clams and sea cucumbers. Conservation has been done by Karimunjawa National Park Authority through protection of life support system activities in order to protect the area from degradation. The objective of the research is to know the implementation of protection and security activities of Karimunjawa National Park Authority for the period of 2012 - 2016. The research was conducted by qualitative method, processing secondary data from Karimunjawa National Park Authority and interview with key informants. The results showed that protection and security activities in The Karimunjawa National Park were held with three activities: pre-emptive activities, preventive activities and repressive activities. Implementation of conservation policy through protection of life support system is influenced by factors of policy characteristic, resource factor and environmental policy factor. Implementation of conservation policy need support from various parties, not only Karimunjawa National Park Authority as the manager of the area, but also need participation of Jepara Regency, Central Java Provinces, communities, NGOs, researchers, developers and tourism actors to maintain and preserve existing biodiversity. Improving the quality of implementors through education and training activities, the availability of the state budget annually and the support of stakeholders is essential for conservation.

Overview of Section 401 Certification and Focusing on Wetlands

EPA Pesticide Factsheets

How EPA can assist States and Tribes in taking more active roles in making wetland decisions and how States and Tribes can use their water quality standards in Section 401 certifications to protect wetlands.

Policies to protect persons with dementia in assisted living: déjà vu all over again?

PubMed

Kaskie, Brian P; Nattinger, Matthew; Potter, Andrew

2015-04-01

Continued growth in the number of individuals with dementia residing in assisted living (AL) raises concerns about their safety and protection. In this Forum, we review current AL practices relevant to residents with dementia and present a rationale for examining the government role in protecting these individuals within this context. Since public oversight of AL is currently a state prerogative, we assess states' regulatory activity across 3 domains closely related to safety and protection of persons with dementia: environmental features, staffing, and use of chemical restraints. We then step back to consider the state policymaking environment and assess the feasibility of developing a minimum standard of regulations from one state to the next. This Forum concludes with a historical comparison between the contemporary AL market and the nursing home care market prior to the Nursing Home Reform Act of 1987, and we discuss how an increased amount of federal interest could improve existing state efforts to protect persons with dementia residing in AL. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Measuring the Impact of Child Protection through Activation States

ERIC Educational Resources Information Center

Brackenridge, Celia H.; Pawlaczek, Zofia; Bringer, Joy D.; Cockburn, Claudi; Nutt, Gareth; Pitchford, Andy; Russell, Kate

2005-01-01

Child protection (CP) has risen to the top of the UK sports policy agenda in the past four years and the Football Association has invested in this major strategy as part of its commitment to "use the power of football to build a better future" (Football Association, 2000a). Evidencing the impact of child protection is, however, a complex…

Challenging and Preventing Policies That Prohibit Local Civil Rights Protections for Lesbian, Gay, Bisexual, Transgender, and Queer People.

PubMed

Pomeranz, Jennifer L

2018-01-01

Discrimination causes health inequities for stigmatized groups. Lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals, in particular, are at significantly increased risk for disparate health outcomes when they reside in states that fail to extend equal protections to them or that actively deprive equal rights to them. Several states and the federal government have proposed or enacted laws that permit residents to discriminate against LGBTQ individuals. One such law, Arkansas's Intrastate Commerce Improvement Act of 2015, preempts or prohibits local governments from enacting civil rights protections for LGBTQ individuals that are also lacking at the state level. State laws such as Arkansas's undermine local control, damage the economy, and create injustices that harm LGBTQ people. I set forth 2 constitutional arguments to challenge such laws, and I provide information to help advocates support evidence-based policymaking and prevent the passage of similar laws in their states.

Cooperative forestry assistance in the Northeast

Treesearch

David A. Gansner; Owen W. Herrick

1980-01-01

Summarizes results of a recent inventory of service forester activities in 20 Northeastern States. Each year some 500 local state foresters give one-half million hours of technical assistance and advice about the management of forest resources to nearly 50,000 woodland owners. Yearly on-the-ground help with activities ranging from timber sales to shade tree protection...

40 CFR 121.21 - When Administrator certifies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... activity requiring a license or permit will not violate applicable water quality standards will be required... respect to those water quality standards promulgated by him; or (b) Water quality standards have been... Section 121.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE...

40 CFR 121.21 - When Administrator certifies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... activity requiring a license or permit will not violate applicable water quality standards will be required... respect to those water quality standards promulgated by him; or (b) Water quality standards have been... Section 121.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS STATE...

Prepared by: U.S. Environmental Protection Agency Office of Water Regulations and Standards Office of Wetlands Protection June 1990

EPA Pesticide Factsheets

Information and guidance on the coordination of State and Federal Non-Point Source (CWA, Section 319) control and wetland programs (CWA, Section 404)and the implementation of activities that can benefit both programs

Protective effect of poly (α- L-glutamate) against UV and γ-irradiation

NASA Astrophysics Data System (ADS)

Furuta, Masakazu; Huy, Nguyen Quang; Tsuchiya, Akihito; Nakatsuka, Hiroshige; Hayashi, Toshio

2004-09-01

We occasionally found that poly (α- L-glutamate) showed a superior protective effect on enzymes against UV and 60Co-γ irradiation. We selected papain and α-amylase as a model enzyme and irradiated the aqueous solution (10 mg/ml) of each enzyme with UV and 60Co-γ rays in the presence of poly (α- L-glutamate) (α-PGA), poly (glucosyl oxyethyl methacrylate (GEMA)), and glucose (1.25% w/v each). The mixture of the three compounds has a significant protective effect on the activity of papain solution showing 40% of remaining activity twice as much as the control containing no additive at the dose of 15 kGy. Among them, α-PGA showed the highest protecting effect on the both papain and α-amylase even after 10-kGy irradiation at which 50% of the activity was retained. α-PGA also showed significant protective activity on α-amylase against UV both in solution and under dried state.

76 FR 39900 - Agency Information Collection Activities: A National Repository for the Collection and Inventory...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-07

... or additional information, please contact Steven Avato, [email protected] , U.S. Bomb Data Center..., Tobacco, Firearms and Explosives (ATF)--United States Bomb Data Center (USBDC). State, Local and Tribal...

AN UPDATE ON SOME ARSENIC PROJECTS AT THE UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

ABSTRACT Exposure to arsenic (As) has been reported to cause many adverse health effects in humans, including internal and skin cancers, vascular, neurological and dermal manifestations. Some Offices of the US Environmental Protection Agency (EPA) deal with As and selected activ...

Nursing research in the United States: the protection of human subjects.

PubMed

Oddi, L F; Cassidy, V R

1990-01-01

In the United States the protection of the rights of human subjects in experimentation has evolved at three levels: professional, public, and private. At the professional level, codes, guidelines and the Patient's Bill of Rights address the issues of protecting the dignity, privacy and autonomy of individuals who serve as research subjects. At the public level, regulations promulgated by the Food and Drug Administration and the Department of Health and Human Services have become the standard for protecting human subjects. At the private level, United States common law regulates the conduct of individual researchers by requiring them to act in a manner consistent with generally accepted standards of care. As professionals, nurses must be actively involved in the formation of public policy regarding the conduct of research and strive to formulate a research agenda that will ensure that the ethics of research in nursing is above question.

Sandalwood: current interest and activity by the Hawaii Division of Forestry and Wildlife

Treesearch

Mark Scheffel

1990-01-01

The State of Hawaii Department of Land & Natural Resources (DLNR) protects native species growing on State land, but has no official program funding for growing sandalwood. Part of the DLNR, the Division of Forestry and Wildlife forest and nursery managers maintain exuberant activity in attempting to establish their nursery stock of sandalwood in the field out of...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A NUCLEAR POWERED ELECTRICAL GENERATING STATION.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF COMMERCIAL REFRIGERATION UNITS

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF COMMERCIAL REFRIGERATION UNITS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF ARTISTS' SUPPLY PAINTS.

EPA Science Inventory

The Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small to medium sized businesses in the state of New Jersey. One of the sites...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF ELECTROPLATING CHEMICAL PRODUCTS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A SCRAP METAL RECOVERY FACILITY.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF ORTHOPEDIC IMPLANTS

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF ORTHOPEDIC IMPLANTS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

75 FR 2535 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OW-2006-0394; FRL-9103-7; EPA ICR No. 1569.07; OMB Control...; Comment Request; Approval of State Coastal Nonpoint Pollution Control Programs (Renewal) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act...

Protecting Our Children from Skin Cancer.

ERIC Educational Resources Information Center

Martin, Paul

1993-01-01

Skin cancer in the United States is epidemic. About 90% of skin cancers are caused by sun exposure. The age of patients developing melanoma is dropping dramatically. Parents must protect their children from the sun during all outdoor activities year round. The article presents recommendations for preventing skin cancer. (SM)

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A REMANUFACTURER OF AUTOMOBILE RADIATORS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A REMANUFACTURER OF AUTOMOBILE RADIATORS

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF WRITING INSTRUMENTS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR AN AUTOBODY REPAIR FACILITY.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF HARDENED STEEL GEARS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small to medium sized businesses in the state of New Jersey. One of the...

Groundwater: Illinois' Buried Treasure. Education Activity Guide.

ERIC Educational Resources Information Center

Environmental Education Association of Illinois, Chicago.

Groundwater is an extremely valuable resource that many feel has been too long neglected and taken for granted. There is growing recognition in Illinois and throughout the United States that comprehensive groundwater protection measures are vital. Illinois embarked on a course in protecting groundwater resources with the passage of the Illinois…

40 CFR 123.63 - Criteria for withdrawal of State programs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... programs. 123.63 Section 123.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER... requirements of this part, including: (i) Failure to exercise control over activities required to be regulated... regulatory program for developing water quality-based effluent limits in NPDES permits. (6) Where a Great...

40 CFR 123.63 - Criteria for withdrawal of State programs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... programs. 123.63 Section 123.63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER... requirements of this part, including: (i) Failure to exercise control over activities required to be regulated... regulatory program for developing water quality-based effluent limits in NPDES permits. (6) Where a Great...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF FINISHED LEATHER.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF ELECTROPLATED WIRE.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A NUCLEAR POWERED ELECTRICAL GENERATING STATION

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A TRANSPORTER OF BULK PLASTIC PELLETS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

Resource Use Among Rural Agricultural Households Near Protected Areas in Vietnam: The Social Costs of Conservation and Implications for Enforcement

NASA Astrophysics Data System (ADS)

McElwee, Pamela D.

2010-01-01

This article examines the use of forests in a protected area by nearby agriculturalists in central Vietnam. Research indicates that the majority of rural farmers interviewed who lived near a state designated protected area were receiving both subsistence and cash incomes from forest-based activities, primarily from the collection of forest products. However, much of the collection of forest produce was officially illegal, as it occurred in state protected forests, and interdiction efforts were on the increase. Yet, little attention has been paid in Vietnam to the need for income substitution for households who lose access to forest produce as a result of conservation enforcement, particularly in the case of farmers who live near, but not in, protected areas; their resources use has been ‘invisible’ due to a lack of attention and research on the topic. This misunderstanding of the importance of forests to rural farmers has the potential to result in households facing adverse welfare and livelihood outcomes as protected areas boundaries are tightened, and local communities face increased opportunity costs due to stricter conservation enforcement. The article concludes that substitution for loss of income due to conservation activities would best be achieved through carefully targeted interventions to specific high-impact and high-dependency households. Additionally, investments in new sources of wage labor and other low capital-input activities, rather than in agriculture, would likely be of most benefit.

JPRS Report, Supplement. East Europe: Recent Legislation

DTIC Science & Technology

1991-07-19

land must assure its cultivation and its soil protection . Article 54. Land owners who do not fulfill the obligations stipulated in article 53, will be...phenomena or from economic and social activities. Soil protection and improvement work is based on studies and projects undertaken at the request of...them, by units specializing in such work. The state supports the performance of soil protection and improvement projects, partially or totally

Integrated Passive Biological Treatment System/ Mine Waste Technology Program Report #16

EPA Science Inventory

This report summarizes the results of the Mine Waste Technology Program (MWTP) Activity III, Project 16, Integrated, Passive Biological Treatment System, funded by the United States Environmental Protection Agency (EPA) and jointly administered by EPA and the United States Depar...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF ROOM AIR CONDITIONING UNITS AND HUMIDIFIERS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE), to assist in conducting waste minimization assessments at thirty small to medium sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A FOSSIL FUEL-FIRED ELECTRICAL GENERATING STATION.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF FINE CHEMICALS USING BATCH PROCESSES.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small to medium sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF PAINTS PRIMARILY FOR METAL FINISHING.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A LOCAL BOARD OF EDUCATION IN NEW JERSEY.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at 30 small- to medium-sized businesses in the state of New Jersey. One of the si...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF SYSTEMS TO PRODUCE SEMICONDUCTORS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

WASTE REDUCTION ACTIVITIES AND OPTIONS AT A PRINTER OF FORMS AND SUPPLIES FOR THE LEGAL PROFESSION

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small-to medium-sized businesses in the state of New Jersey. One of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A FOSSIL FUEL-FIRED ELECTRICAL GENERATING STATION

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A LAMINATOR OF PAPER AND CARDBOARD PACKAGES.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR AN ELECTRICAL UTILITY TRANSMISSION SYSTEM MONITORING AND MAINTENANCE FACILITY

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR AN ELECTRICAL UTILITY TRANSMISSION SYSTEM MONITORING AND MAINTENANCE FACILITY.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A PRINTING PLATE PREPARATION SECTION OF A NEWSPAPER.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF PLASTIC CONTAINERS BY INJECTION MOLDING.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. ne of the ...

UTILIZING SOCIAL MEDIA AND PROTECTING MILITARY MEMBERS AND THEIR FAMILIES

DTIC Science & Technology

2016-02-01

is the property of the United States Government. iii Table of Contents Disclaimer...ii Table of Contents ...According to Facebook, it had 12 million active users in 2006, 500 million active users in 2010, and 1.65 billion active users in 2014.7 The DoD

Building Stronger State Partnerships with the US Department of Energy (Energy Assurance)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mike Keogh

2011-09-30

From 2007 until 2011, the National Association of Regulatory Utility Commissioners (NARUC) engaged in a partnership with the National Energy Technology Lab (NETL) to improve State-Federal coordination on electricity policy and energy assurance issues. This project allowed State Public Utility Commissioners and their staffs to engage on the most cutting-edge level in the arenas of energy assurance and electricity policy. Four tasks were outlined in the Statement of Performance Objectives: Task 1 - Training for Commissions on Critical Infrastructure Topics; Task 2 - Analyze and Implement Recommendations on Energy Assurance Issues; Task 3 - Ongoing liaison activities & outreach tomore » build stronger networks between federal agencies and state regulators; and Task 4 - Additional Activities. Although four tasks were prescribed, in practice these tasks were carried out under two major activity areas: the critical infrastructure and energy assurance partnership with the US Department of Energy's Infrastructure Security and Emergency Response office, and the National Council on Electricity Policy, a collaborative which since 1994 has brought together State and Federal policymakers to address the most pressing issues facing the grid from restructuring to smart grid implementation. On Critical Infrastructure protection, this cooperative agreement helped State officials yield several important advances. The lead role on NARUC's side was played by our Committee on Critical Infrastructure Protection. Key lessons learned in this arena include the following: (1) Tabletops and exercises work - They improve the capacity of policymakers and their industry counterparts to face the most challenging energy emergencies, and thereby equip these actors with the capacity to face everything up to that point as well. (2) Information sharing is critical - Connecting people who need information with people who have information is a key success factor. However, exposure of critical infrastructure information to bad actors also creates new vulnerabilities. (3) Tensions exist between the transparency-driven basis of regulatory activity and the information-protection requirements of asset protection. (4) Coordination between states is a key success factor - Because comparatively little federal authority exists over electricity and other energy infrastructure, the interstate nature of these energy grids defy centralized command and control governance. Patchwork responses are a risk when addressed at a state-by-state level. Coordination is the key to ensuring consistent response to shared threats. In Electricity Policy, the National Council on Electricity Policy continued to make important strides forward. Coordinated electricity policy among States remains the best surrogate for an absent national electricity policy. In every area from energy efficiency to clean coal, State policies are driving the country's electricity policy, and regional responses to climate change, infrastructure planning, market operation, and new technology deployment depend on a forum for bringing the States together.« less

76 FR 9849 - Comprehensive Environmental Evaluations for Antarctic Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-22

... DEPARTMENT OF STATE [Public Notice 7340] Comprehensive Environmental Evaluations for Antarctic... Environmental Evaluations (CEEs) for activities proposed to be undertaken in Antarctica. Interested members of... on Environmental Protection to the Antarctic Treaty requires the preparation of a CEE for any...

Biological Criteria for Protection of U.S. Coral Reefs.

EPA Science Inventory

Coral reef ecosystems are threatened by natural stressors, human activities, and natural stressors exacerbated by human activities. Under the U.S. Clean Water Act, States and Territories may guard against anthropogenic threats by adopting water quality standards based on biologic...

Biological Criteria for Protection of U.S. Coral Reefs

EPA Science Inventory

Coral reef ecosystems are threatened by natural stressors, human activities, and natural stressors exacerbated by human activities. Under the U.S. Clean Water Act, States and Territories may guard against anthropogenic threats by adopting water quality standards based on biologic...

Integrating technical rock climbing into protected area management: a case example of Minnewaska State Park Preserve, New York State

Treesearch

Jennifer A. Cairo; Thomas L. Cobb

1998-01-01

In the fall of 1996, technical rock climbing was introduced as a regulated outdoor recreation activity in Minnewaska State Park Preserve, situated in the Shawangunk Mountain region of New York State. It is the first instance in which rock climbing has been sanctioned by the New York State Office of Parks, Recreation and Historic Preservation. This paper identifies key...

Wyoming groundwater-quality monitoring network

USGS Publications Warehouse

Boughton, Gregory K.

2011-01-01

A wide variety of human activities have the potential to contaminate groundwater. In addition, naturally occurring constituents can limit the suitability of groundwater for some uses. The State of Wyoming has established rules and programs to evaluate and protect groundwater quality based on identified uses. The Wyoming Groundwater-Quality Monitoring Network (WGQMN) is a cooperative program between the U.S. Geological Survey (USGS) and the Wyoming Department of Environmental Quality (WDEQ) and was implemented in 2009 to evaluate the water-quality characteristics of the State's groundwater. Representatives from USGS, WDEQ, U.S. Environmental Protection Agency (USEPA), Wyoming Water Development Office, and Wyoming State Engineer's Office formed a steering committee, which meets periodically to evaluate progress and consider modifications to strengthen program objectives. The purpose of this fact sheet is to describe the WGQMN design and objectives, field procedures, and water-quality analyses. USGS groundwater activities in the Greater Green River Basin also are described.

A spatial database of wildfires in the United States, 1992-2011

Treesearch

K. C. Short

2014-01-01

The statistical analysis of wildfire activity is a critical component of national wildfire planning, operations, and research in the United States (US). However, there are multiple federal, state, and local entities with wildfire protection and reporting responsibilities in the US, and no single, unified system of wildfire record keeping exists. To conduct even the...

A spatial database of wildfires in the United States, 1992-2011 [Discussions

Treesearch

K. C. Short

2013-01-01

The statistical analysis of wildfire activity is a critical component of national wildfire planning, operations, and research in the United States (US). However, there are multiple federal, state, and local entities with wildfire protection and reporting responsibilities in the US, and no single, unified system of wildfire record-keeping exists. To conduct even the...

The protective effect of salicylic acid on lysozyme against riboflavin-mediated photooxidation

NASA Astrophysics Data System (ADS)

Li, Kun; Wang, Hongbao; Cheng, Lingli; Zhu, Hui; Wang, Mei; Wang, Shi-Long

2011-06-01

As a metabolite of aspirin in vivo, salicylic acid was proved to protect lysozyme from riboflavin-mediated photooxidation in this study. The antioxidative properties of salicylic acid were further studied by using time-resolved laser flash photolysis of 355 nm. It can quench the triplet state of riboflavin via electron transfer from salicylic acid to the triplet state of riboflavin with a reaction constant of 2.25 × 10 9 M -1 s -1. Mechanism of antioxidant activities of salicylic acid on lysozyme oxidation was discussed. Salicylic acid can serve as a potential antioxidant to quench the triplet state of riboflavin and reduce oxidative pressure.

Highlights of Fire in the United States: Deaths, Injuries, Dollar Loss, and Incidents at the National, State, and Local Levels.

ERIC Educational Resources Information Center

National Fire Prevention and Control Administration (DOC), Washington, DC. National Fire Data Center.

This report provides fire departments, federal and state governments, and others active in the fire protection field with information which can be used to improve the efficacy and targeting of fire prevention programs. As a byproduct, it illustrates ways that state and local governments might analyze their own fire problems. The report describes…

29 CFR 500.162 - Reports.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Reports. 500.162 Section 500.162 Labor Regulations Relating... AGRICULTURAL WORKER PROTECTION Enforcement Agreements with Federal and State Agencies § 500.162 Reports. The Secretary shall require such reports as he deems necessary of activities conducted pursuant to State plans...

29 CFR 500.162 - Reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Reports. 500.162 Section 500.162 Labor Regulations Relating... AGRICULTURAL WORKER PROTECTION Enforcement Agreements with Federal and State Agencies § 500.162 Reports. The Secretary shall require such reports as he deems necessary of activities conducted pursuant to State plans...

29 CFR 500.162 - Reports.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Reports. 500.162 Section 500.162 Labor Regulations Relating... AGRICULTURAL WORKER PROTECTION Enforcement Agreements with Federal and State Agencies § 500.162 Reports. The Secretary shall require such reports as he deems necessary of activities conducted pursuant to State plans...

Trotter welfare’s protection: A legislative perspective

PubMed Central

Passantino, Annamaria; Giannetto, Claudia; Passantino, Letizia; Piccione, Giuseppe

2015-01-01

The Council of Europe’s activities in the field of animal welfare are particularly noteworthy and comprise the elaboration of several norms for the protection of animals. Concerning the specific European Directive, Regulations or Convention for the protection of animals, the Authors underline the missing of specifics recommendations concerning the welfare of sport horses and especially of trotters. Guidelines are reported by regulation of equestrian sports. The paper’s purpose is to give practical elements to individuate the welfare state and to promote a clear regulation on welfare, care and protection of trotters. PMID:27047109

A NASA/University/Industry Consortium for Research on Aircraft Ice Protection

NASA Technical Reports Server (NTRS)

Zumwalt, Glen W.

1989-01-01

From 1982 through 1987, an unique consortium was functioning which involved government (NASA), academia (Wichita State Univ.) and twelve industries. The purpose was the development of a better ice protection systems for aircraft. The circumstances which brought about this activity are described, the formation and operation recounted, and the effectiveness of the ventue evaluated.

Home-Schools and Interscholastic Sports: Denying Participation Violates United States Constitutional Due Process and Equal Protection Rights. Chalk Talk.

ERIC Educational Resources Information Center

Webb, Derwin L.

1997-01-01

Participation in sports, in some instances, is considered a right which grants students the opportunity to be involved in extracurricular activities. Discusses the potential violation of home-schooled students' constitutional due process and equal protection rights and the pertinent laws regarding students and their ability to participate in…

78 FR 9927 - Agency Information Collection Activities; Proposed Collection; Comment Request; State Program Report

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-12

... Community Living, HHS. ACTION: Notice. SUMMARY: The Administration for Community Living (ACL) is announcing... information to: [email protected]acl.hhs.gov Submit written comments on the collection of information to: U.S...: [email protected]acl.hhs.gov . SUPPLEMENTARY INFORMATION: Under the PRA (44 U.S.C. 3501-3520), Federal...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF FIRE RETARDANT PLASTIC PELLETS AND HOT MELT ADHESIVES.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small to medium sized businesses in the state of New Jersey. One of the...

ENVIRONMENTAL RESEARCH BRIEF: WASTE REDUCTION ACTIVITIES AND OPTIONS FOR A MANUFACTURER OF WIRE STOCK USED FOR PRODUCTION OF METAL ITEMS.

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) funded a project with the New Jersey Department of Environmental Protection and Energy (NJDEPE) to assist in conducting waste minimization assessments at thirty small- to medium-sized businesses in the state of New Jersey. One of th...

Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt.

PubMed

Murata, Hiroaki; Ihara, Yoshito; Nakamura, Hajime; Yodoi, Junji; Sumikawa, Koji; Kondo, Takahito

2003-12-12

Glutaredoxin (GRX) is a small dithiol protein involved in various cellular functions, including the redox regulation of certain enzyme activities. GRX functions via a disulfide exchange reaction by utilizing the active site Cys-Pro-Tyr-Cys. Here we demonstrated that overexpression of GRX protected cells from hydrogen peroxide (H2O2)-induced apoptosis by regulating the redox state of Akt. Akt was transiently phosphorylated, dephosphorylated, and then degraded in cardiac H9c2 cells undergoing H2O2-induced apoptosis. Under stress, Akt underwent disulfide bond formation between Cys-297 and Cys-311 and dephosphorylation in accordance with an increased association with protein phosphatase 2A. Overexpression of GRX protected Akt from H2O2-induced oxidation and suppressed recruitment of protein phosphatase 2A to Akt, resulting in a sustained phosphorylation of Akt and inhibition of apoptosis. This effect was reversed by cadmium, an inhibitor of GRX. Furthermore an in vitro assay revealed that GRX reduced oxidized Akt in concert with glutathione, NADPH, and glutathione-disulfide reductase. Thus, GRX plays an important role in protecting cells from apoptosis by regulating the redox state of Akt.

40 CFR 35.3535 - Authorized set-aside activities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... demonstrate how the purchase of land or easements will protect the source water of the system from... ASSISTANCE STATE AND LOCAL ASSISTANCE Drinking Water State Revolving Funds § 35.3535 Authorized set-aside... DWSRF program and to provide technical assistance to public water systems. (c) Small systems technical...

40 CFR 35.3535 - Authorized set-aside activities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... demonstrate how the purchase of land or easements will protect the source water of the system from... ASSISTANCE STATE AND LOCAL ASSISTANCE Drinking Water State Revolving Funds § 35.3535 Authorized set-aside... DWSRF program and to provide technical assistance to public water systems. (c) Small systems technical...

77 FR 34409 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; General...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... for OMB Review; Comment Request; General Inquiries to State Agency Contacts ACTION: Notice. SUMMARY... collection request (ICR) titled, ``General Inquiries to State Agency Contacts,'' to the Office of Management... (these are not toll-free numbers), email: [email protected] . FOR FURTHER INFORMATION CONTACT...

Interfacing broadband photonic qubits to on-chip cavity-protected rare-earth ensembles

PubMed Central

Zhong, Tian; Kindem, Jonathan M.; Rochman, Jake; Faraon, Andrei

2017-01-01

Ensembles of solid-state optical emitters enable broadband quantum storage and transduction of photonic qubits, with applications in high-rate quantum networks for secure communications and interconnecting future quantum computers. To transfer quantum states using ensembles, rephasing techniques are used to mitigate fast decoherence resulting from inhomogeneous broadening, but these techniques generally limit the bandwidth, efficiency and active times of the quantum interface. Here, we use a dense ensemble of neodymium rare-earth ions strongly coupled to a nanophotonic resonator to demonstrate a significant cavity protection effect at the single-photon level—a technique to suppress ensemble decoherence due to inhomogeneous broadening. The protected Rabi oscillations between the cavity field and the atomic super-radiant state enable ultra-fast transfer of photonic frequency qubits to the ions (∼50 GHz bandwidth) followed by retrieval with 98.7% fidelity. With the prospect of coupling to other long-lived rare-earth spin states, this technique opens the possibilities for broadband, always-ready quantum memories and fast optical-to-microwave transducers. PMID:28090078

Interfacing broadband photonic qubits to on-chip cavity-protected rare-earth ensembles

NASA Astrophysics Data System (ADS)

Zhong, Tian; Kindem, Jonathan M.; Rochman, Jake; Faraon, Andrei

2017-01-01

Ensembles of solid-state optical emitters enable broadband quantum storage and transduction of photonic qubits, with applications in high-rate quantum networks for secure communications and interconnecting future quantum computers. To transfer quantum states using ensembles, rephasing techniques are used to mitigate fast decoherence resulting from inhomogeneous broadening, but these techniques generally limit the bandwidth, efficiency and active times of the quantum interface. Here, we use a dense ensemble of neodymium rare-earth ions strongly coupled to a nanophotonic resonator to demonstrate a significant cavity protection effect at the single-photon level--a technique to suppress ensemble decoherence due to inhomogeneous broadening. The protected Rabi oscillations between the cavity field and the atomic super-radiant state enable ultra-fast transfer of photonic frequency qubits to the ions (~50 GHz bandwidth) followed by retrieval with 98.7% fidelity. With the prospect of coupling to other long-lived rare-earth spin states, this technique opens the possibilities for broadband, always-ready quantum memories and fast optical-to-microwave transducers.

78 FR 10128 - Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

...: [email protected] . Title: Emergency and Imminent Community Water Assistance Grants. OMB Control..., incorporated towns and villages, boroughs, authorities, districts, and other political subdivisions of a state...

Substrate-permeable encapsulation of enzymes maintains effective activity, stabilizes against denaturation, and protects against proteolytic degradation.

PubMed

Nasseau, M; Boublik, Y; Meier, W; Winterhalter, M; Fournier, D

2001-12-05

How can enzymes be protected against denaturation and proteolysis while keeping them in a fully functional state? One solution is to encapsulate the enzymes into liposomes, which enhances their stability against denaturation and proteases. However, the permeability barrier of the lipid membrane drastically reduces the activity of enzyme entrapped in the liposome by reducing the internal concentration of the substrate. To overcome this problem, we permeabilized the wall of the liposome by reconstitution of a porin from Escherichia coli. In this way, we recovered the full functionality of the enzyme while retaining the protection against denaturation and proteolytic enzymes. Copyright 2001 John Wiley & Sons, Inc.

USEPA QUALITY ASSURANCE AUDITOR IS SCHEDULED FOR A VISIT. WHAT CAN I EXPECT?

EPA Science Inventory

Environmental studies involving data collection activities conducted by or for the United States Environmental Protection Agency (USEPA) are required to undergo a review of their data collection activities. his review is usually in the form of an independent quality assurance (QA...

75 FR 57034 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed Information Collection Activity; Comment Request Proposed Projects Title: State Personal Responsibility Education Program (PREP). OMB No.: 0970-0380. Description: The Patient Protection and Affordable Care Act, 2010, also known as health care reform, amends...

78 FR 39297 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed Information Collection Activity; Comment Request Proposed Projects Title: State Personal Responsibility Education Program (PREP). OMB No.: 0970-0380. Description: The Patient Protection and Affordable Care Act, 2010, also known as health care reform, amends...

40 CFR 35.6225 - Activities eligible for funding under Core Program Cooperative Agreements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Core Program Cooperative Agreements. 35.6225 Section 35.6225 Protection of Environment ENVIRONMENTAL... Superfund State Contracts for Superfund Response Actions Core Program Cooperative Agreements § 35.6225 Activities eligible for funding under Core Program Cooperative Agreements. (a) To be eligible for funding...

40 CFR 35.6225 - Activities eligible for funding under Core Program Cooperative Agreements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Core Program Cooperative Agreements. 35.6225 Section 35.6225 Protection of Environment ENVIRONMENTAL... Superfund State Contracts for Superfund Response Actions Core Program Cooperative Agreements § 35.6225 Activities eligible for funding under Core Program Cooperative Agreements. (a) To be eligible for funding...

Tangible and Intangible Costs of "Protecting Human Subjects": The Impact of the National Research Act of 1974 on University Research Activities

ERIC Educational Resources Information Center

Jacobs, Frederic; Zonnenberg, Arina

2004-01-01

This article (1) examines the overall structure of regulatory research oversight in the United States; (2) details the origins and evolution of federal legislation pertaining to the protection of human subjects in biomedical and behavioral treatment and research; and (3) describes the expansion of oversight regulation from biomedical and…

β-Sitosterol enhances cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration: protection against oxidant injury in H9c2 cells and rat hearts.

PubMed

Wong, Hoi Shan; Chen, Na; Leong, Pou Kuan; Ko, Kam Ming

2014-07-01

Herba Cistanches (Cistanche deserticola Y. C. Ma) is a 'Yang-invigorating' tonic herb in Chinese medicine. Preliminary chemical analysis indicated that β-sitosterol (BS) is one of the chemical constituents in an active fraction of Herba Cistanches. To investigate whether BS is an active ingredient of Herba Cistanches, the effects of BS on H9c2 cells and rat hearts were examined. The results indicated that BS stimulated the mitochondrial ATP generation capacity in H9c2 cells, which was associated with the increased production of mitochondrial reactive oxygen species. BS also stimulated mitochondrial state 3 and state 4 respiration, with the resultant decrease in coupling efficiency. BS produced an up-regulation of cellular glutathione redox cycling and protected against hypoxia/reoxygenation-induced apoptosis in H9c2 cells. However, the protective effect of BS against myocardial ischemia/reperfusion injury was seen in female but not male rats ex vivo. The cardioprotection afforded by BS was likely mediated by an up-regulation of mitochondrial glutathione redox cycling in female rat hearts. In conclusion, the ensemble of results suggests that BS is an active ingredient of Herba Cistanches. The gender-dependent effect of BS on myocardial protection will further be investigated. Copyright © 2013 John Wiley & Sons, Ltd.

Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90.

PubMed Central

Conconi, M; Petropoulos, I; Emod, I; Turlin, E; Biville, F; Friguet, B

1998-01-01

Heat-shock protein 90 (Hsp 90) has been implicated in both protection against oxidative inactivation and inhibition of the multicatalytic proteinase (MCP, also known as 20 S proteasome). We report here that the protective and inhibitory effects of Hsp 90 depend on the activation state of the proteasome. Hsp 90 (and also alpha-crystallin) inhibits the N-Cbz-Leu-Leu-Leu-MCA-hydrolysing activity (Cbz=benzyloxycarbonyl; MCA=7-amido-4-methylcoumarin) when the rat liver MCP is in its latent form, but no inhibitory effects are observed when the MCP is in its active form. Metal-catalysed oxidation of the active MCP inactivates the Ala-Ala-Phe-MCA-hydrolysing (chymotrypsin-like), N-Boc-Leu-Ser-Thr-Arg-MCA-hydrolysing (trypsin-like; Boc=t-butyloxycarbonyl), N-Cbz-Leu-Leu-Glu-beta-naphthylamine-hydrolysing (peptidylglutamyl-peptide hydrolase) and N-Cbz-Leu-Leu-Leu-MCA-hydrolysing activities, whereas these activities are actually increased when the MCP is in its latent form. Hsp 90 protects against oxidative inactivation of the trypsin-like and N-Cbz-Leu-Leu-Leu-MCA-hydrolysing activities of the MCP active form, and alpha-crystallin protects the trypsin-like activity. The specificity of the Hsp 90-mediated protection was assessed by a quantitative analysis of the two-dimensional electrophoretic pattern of MCP subunits before and after oxidation of the MCP, in the presence or absence of Hsp 90. Treatment of the FAO hepatoma cell line with iron and ascorbate was found to inactivate the MCP. Hsp 90 overexpression obtained by challenging the cells with iron was associated with a decreased susceptibility to oxidative inactivation of the MCP trypsin-like activity. Depletion of Hsp 90 by using antisense oligonucleotides resulted in an increased susceptibility to oxidative inactivation of the MCP trypsin-like activity, providing evidence for the physiological relevance of Hsp 90-mediated protection of the MCP. PMID:9657982

Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90.

PubMed

Conconi, M; Petropoulos, I; Emod, I; Turlin, E; Biville, F; Friguet, B

1998-07-15

Heat-shock protein 90 (Hsp 90) has been implicated in both protection against oxidative inactivation and inhibition of the multicatalytic proteinase (MCP, also known as 20 S proteasome). We report here that the protective and inhibitory effects of Hsp 90 depend on the activation state of the proteasome. Hsp 90 (and also alpha-crystallin) inhibits the N-Cbz-Leu-Leu-Leu-MCA-hydrolysing activity (Cbz=benzyloxycarbonyl; MCA=7-amido-4-methylcoumarin) when the rat liver MCP is in its latent form, but no inhibitory effects are observed when the MCP is in its active form. Metal-catalysed oxidation of the active MCP inactivates the Ala-Ala-Phe-MCA-hydrolysing (chymotrypsin-like), N-Boc-Leu-Ser-Thr-Arg-MCA-hydrolysing (trypsin-like; Boc=t-butyloxycarbonyl), N-Cbz-Leu-Leu-Glu-beta-naphthylamine-hydrolysing (peptidylglutamyl-peptide hydrolase) and N-Cbz-Leu-Leu-Leu-MCA-hydrolysing activities, whereas these activities are actually increased when the MCP is in its latent form. Hsp 90 protects against oxidative inactivation of the trypsin-like and N-Cbz-Leu-Leu-Leu-MCA-hydrolysing activities of the MCP active form, and alpha-crystallin protects the trypsin-like activity. The specificity of the Hsp 90-mediated protection was assessed by a quantitative analysis of the two-dimensional electrophoretic pattern of MCP subunits before and after oxidation of the MCP, in the presence or absence of Hsp 90. Treatment of the FAO hepatoma cell line with iron and ascorbate was found to inactivate the MCP. Hsp 90 overexpression obtained by challenging the cells with iron was associated with a decreased susceptibility to oxidative inactivation of the MCP trypsin-like activity. Depletion of Hsp 90 by using antisense oligonucleotides resulted in an increased susceptibility to oxidative inactivation of the MCP trypsin-like activity, providing evidence for the physiological relevance of Hsp 90-mediated protection of the MCP.

Hanford Site Groundwater Protection Management Program: Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Groundwater protection is a national priority that is promulgated in a variety of environmental regulations at local, state, and federal levels. To effectively coordinate and ensure compliance with applicable regulations, the US Department of Energy has issued DOE Order 5400.1 (now under revision) that requires all US Department of Energy facilities to prepare separate groundwater protection program descriptions and plans. This document describes the Groundwater Protection Management Program for the Hanford Site located in the state of Washington. DOE Order 5400.1 specifies that the Groundwater Protection Management Program cover the following general topical areas: (1) documentation of the groundwater regime,more » (2) design and implementation of a groundwater monitoring program to support resource management and comply with applicable laws and regulations, (3) a management program for groundwater protection and remediation, (4) a summary and identification of areas that may be contaminated with hazardous waste, (5) strategies for controlling these sources, (6) a remedial action program, and (7) decontamination and decommissioning and related remedial action requirements. Many of the above elements are covered by existing programs at the Hanford Site; thus, one of the primary purposes of this document is to provide a framework for coordination of existing groundwater protection activities. Additionally, it describes how information needs are identified and can be incorporated into existing or proposed new programs. The Groundwater Protection Management Program provides the general scope, philosophy, and strategies for groundwater protection/management at the Hanford Site. Subtier documents provide the detailed plans for implementing groundwater-related activities and programs. Related schedule and budget information are provided in the 5-year plan for environmental restoration and waste management at the Hanford Site.« less

Antagonist of peroxisome proliferator-activated receptor {gamma} induces cerebellar amyloid-{beta} levels and motor dysfunction in APP/PS1 transgenic mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Du, Jing; Sun, Bing; Chen, Kui

2009-07-03

Recent evidences show that peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) is involved in the modulation of the amyloid-{beta} (A{beta}) cascade causing Alzheimer's disease (AD) and treatment with PPAR{gamma} agonists protects against AD pathology. However, the function of PPAR{gamma} steady-state activity in A{beta} cascade and AD pathology remains unclear. In this study, an antagonist of PPAR{gamma}, GW9662, was injected into the fourth ventricle of APP/PS1 transgenic mice to inhibit PPAR{gamma} activity in cerebellum. The results show that inhibition of PPAR{gamma} significantly induced A{beta} levels in cerebellum and caused cerebellar motor dysfunction in APP/PS1 transgenic mice. Moreover, GW9662 treatment markedly decreased the cerebellarmore » levels of insulin-degrading enzyme (IDE), which is responsible for the cellular degradation of A{beta}. Since cerebellum is spared from significant A{beta} accumulation and neurotoxicity in AD patients and animal models, these findings suggest a crucial role of PPAR{gamma} steady-state activity in protection of cerebellum against AD pathology.« less

Hanford Site Composite Analysis Technical Approach Description: Groundwater Pathway Dose Calculation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morgans, D. L.; Lindberg, S. L.

The purpose of this technical approach document (TAD) is to document the assumptions, equations, and methods used to perform the groundwater pathway radiological dose calculations for the revised Hanford Site Composite Analysis (CA). DOE M 435.1-1, states, “The composite analysis results shall be used for planning, radiation protection activities, and future use commitments to minimize the likelihood that current low-level waste disposal activities will result in the need for future corrective or remedial actions to adequately protect the public and the environment.”

Countering resistance to protected-area extension.

PubMed

Lindenmayer, David; Thorn, Simon; Noss, Reed

2018-04-01

The establishment of protected areas is a critical strategy for conserving biodiversity. Key policy directives like the Aichi targets seek to expand protected areas to 17% of Earth's land surface, with calls by some conservation biologists for much more. However, in places such as the United States, Germany, and Australia, attempts to increase protected areas are meeting strong resistance from communities, industry groups, and governments. We examined case studies of such resistance in Victoria, Australia, Bavaria, Germany, and Florida, United States. We considered 4 ways to tackle this problem. First, broaden the case for protected areas beyond nature conservation to include economic, human health, and other benefits, and translate these into a persuasive business case for protected areas. Second, better communicate the conservation values of protected areas. This should include highlighting how many species, communities, and ecosystems have been conserved by protected areas and the counterfactual (i.e., what would have been lost without protected area establishment). Third, consider zoning of activities to ensure the maintenance of effective management. Finally, remind citizens to think about conservation when they vote, including holding politicians accountable for their environmental promises. Without tackling resistance to expanding the protected estate, it will be impossible to reach conservation targets, and this will undermine attempts to stem the global extinction crisis. © 2017 Society for Conservation Biology.

Experimental evidence of hourglass fermion in the candidate nonsymmorphic topological insulator KHgSb

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Junzhang; Yi, Changjiang; Lv, Baiqing

Topological insulators (TIs) host novel states of quantum matter characterized by nontrivial conducting boundary states connecting valence and conduction bulk bands. All TIs discovered experimentally so far rely on either time-reversal or mirror crystal symmorphic symmetry to protect massless Dirac-like boundary states. Several materials were recently proposed to be TIs with nonsymmorphic symmetry, where a glide mirror protects exotic surface fermions with hourglass-shaped dispersion. However, an experimental confirmation of this new fermion is missing. Using angle-resolved photoemission spectroscopy, we provide experimental evidence of hourglass fermions on the (010) surface of crystalline KHgSb, whereas the (001) surface has no boundary state,more » in agreement with first-principles calculations. Our study will stimulate further research activities of topological properties of nonsymmorphic materials.« less

Experimental evidence of hourglass fermion in the candidate nonsymmorphic topological insulator KHgSb

DOE PAGES

Ma, Junzhang; Yi, Changjiang; Lv, Baiqing; ...

2017-05-05

Topological insulators (TIs) host novel states of quantum matter characterized by nontrivial conducting boundary states connecting valence and conduction bulk bands. All TIs discovered experimentally so far rely on either time-reversal or mirror crystal symmorphic symmetry to protect massless Dirac-like boundary states. Several materials were recently proposed to be TIs with nonsymmorphic symmetry, where a glide mirror protects exotic surface fermions with hourglass-shaped dispersion. However, an experimental confirmation of this new fermion is missing. Using angle-resolved photoemission spectroscopy, we provide experimental evidence of hourglass fermions on the (010) surface of crystalline KHgSb, whereas the (001) surface has no boundary state,more » in agreement with first-principles calculations. Our study will stimulate further research activities of topological properties of nonsymmorphic materials.« less

On getting involved

USGS Publications Warehouse

Banks, Richard C.

1980-01-01

The American Ornithologists' Union and its members had an early history of involvement in public affairs and conservation activities. A very active Committee on Bird Protection was among the first of the service committees to be established. In the 1880s it gathered data on the plumage trade and worked for legislation to protect birds, preparing a model law for the protection of nongame birds that was adopted quickly by two states and later by others. As a direct result of action at the 1884 A.O.U. meeting, the forerunner of the present U.S. Fish and Wildlife Service was established as a government office. The present National Audubon Society was another outgrowth of the A.O.U.'s early conservation and educational activities. In the 1920s the A.O.U. raised funds to establish a bird sanctuary at Olney, Illinois, in honor of Robert Ridgway.

Achieving Accountability in Cyberspace: Revolution or Evolution?

DTIC Science & Technology

2014-01-01

hours, the malware propagates throughout both networks and begins to beacon to a site known for its state - sponsored cyberspace espionage activities...installation in the United States , communications personnel in a tenant unit, whose primary unclassified operating network is neither owned nor...protect its unclas- sified proprietary network. A known nation- state actor gains access to the company’s network and begins to exfil- trate megabytes

State solar initiatives. Volume 1: A review

NASA Astrophysics Data System (ADS)

Koontz, R.; Neuendorffer, J.; Green, B.; Gordon, N.; Myring, G.; Perwin, E.; Poster, B.; Small, D.; Myring, L.

1981-09-01

The impacts of solar energy programs undertaken in California, Florida, New Mexico, Minnesota, and New York are reviewed. Initiatives were explored: information outreach activities; consumer protection programs including standards, testing, certification, warranties, licensing, and consumer complaint offices; and tax credits and rebates. The experience in these five states is analyzed and conclusions and recommendations that will assist state governments in improving or launching their own programs are presented.

ASSESSING VINCLOZOLIN FOR ANTIANDROGENIC ACTIVITY: A DOSE-RESPONSE STUDY OF GENE EXPRESSION IN THE RAT VENTRAL PROSTATE

EPA Science Inventory

The United States Environmental Protection Agency, along with agencies within the European Union, are currently evaluating in vitro and in vivo assays to detect compounds that display antiandrogenic orandrogenic activity. Thein vivo assay is based on weight changes in androgen d...

77 FR 25718 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... Protection and Advocacy Systems Program Performance Report. OMB No.: 0980-0160. Description: This information... a program Performance Report for the preceding fiscal year of activities and accomplishments and of conditions in the State. The information in the Annual Report will be aggregated into a national profile of...

76 FR 4705 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... Protection and Advocacy Systems Program Performance Report. OMB No. 0980-0160. Description: This information... a program Performance Report for the preceding fiscal year of activities and accomplishments and of conditions in the State. The information in the Annual Report will be aggregated into a national profile of...

36 CFR 18.12 - What specific provisions must a lease contain?

Code of Federal Regulations, 2011 CFR

2011-07-01

... to lessee activities; (h) Appropriate provisions stating that the lessee has no rights of renewal of..., minor additions, buildings and/or structures determined by the Director to be necessary for support of the authorized activities of the lessee and otherwise to be consistent with the protection and...

36 CFR 18.12 - What specific provisions must a lease contain?

Code of Federal Regulations, 2014 CFR

2014-07-01

... to lessee activities; (h) Appropriate provisions stating that the lessee has no rights of renewal of..., minor additions, buildings and/or structures determined by the Director to be necessary for support of the authorized activities of the lessee and otherwise to be consistent with the protection and...

36 CFR 18.12 - What specific provisions must a lease contain?

Code of Federal Regulations, 2010 CFR

2010-07-01

... to lessee activities; (h) Appropriate provisions stating that the lessee has no rights of renewal of..., minor additions, buildings and/or structures determined by the Director to be necessary for support of the authorized activities of the lessee and otherwise to be consistent with the protection and...

36 CFR 18.12 - What specific provisions must a lease contain?

Code of Federal Regulations, 2012 CFR

2012-07-01

... to lessee activities; (h) Appropriate provisions stating that the lessee has no rights of renewal of..., minor additions, buildings and/or structures determined by the Director to be necessary for support of the authorized activities of the lessee and otherwise to be consistent with the protection and...

10 CFR 150.31 - Requirements for Agreement State regulation of byproduct material.

Code of Federal Regulations, 2014 CFR

2014-01-01

... include: (A) An assessment of the radiological and nonradiological impacts to the public health of the activities to be conducted pursuant to such licenses; (B) An assessment of any impact on any waterway and... Agreement State for the protection of the public health, safety, and the environment from hazards associated...

10 CFR 150.31 - Requirements for Agreement State regulation of byproduct material.

Code of Federal Regulations, 2010 CFR

2010-01-01

... include: (A) An assessment of the radiological and nonradiological impacts to the public health of the activities to be conducted pursuant to such licenses; (B) An assessment of any impact on any waterway and... Agreement State for the protection of the public health, safety, and the environment from hazards associated...

10 CFR 150.31 - Requirements for Agreement State regulation of byproduct material.

Code of Federal Regulations, 2013 CFR

2013-01-01

... include: (A) An assessment of the radiological and nonradiological impacts to the public health of the activities to be conducted pursuant to such licenses; (B) An assessment of any impact on any waterway and... Agreement State for the protection of the public health, safety, and the environment from hazards associated...

10 CFR 150.31 - Requirements for Agreement State regulation of byproduct material.

Code of Federal Regulations, 2012 CFR

2012-01-01

... include: (A) An assessment of the radiological and nonradiological impacts to the public health of the activities to be conducted pursuant to such licenses; (B) An assessment of any impact on any waterway and... Agreement State for the protection of the public health, safety, and the environment from hazards associated...

Improving Sampling, Analysis, and Data Management for Site Investigation and Cleanup

EPA Pesticide Factsheets

The United States Environmental Protection Agency (EPA) supports the adoption of streamlined approaches to sampling, analysis, and data management activities conducted during site assessment, characterization, and cleanup.

Delta-9-Tetrahydrocannabinol Potentiates Fear Memory Salience Through Functional Modulation of Mesolimbic Dopaminergic Activity States.

PubMed

Fitoussi, Aurelie; Zunder, Jordan; Tan, Huibing; Laviolette, Steven R

2018-05-18

Chronic or acute exposure to delta-9-tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, has been associated with numerous neuropsychiatric side-effects, including dysregulation of emotional processing and associative memory formation. Clinical and pre-clinical evidence suggests that the effects of THC are due to the ability to modulate mesolimbic dopamine (DA) activity states in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Nevertheless, the mechanisms by which THC modulates mesolimbic DA function and emotional processing are not well understood. Using an olfactory associative fear memory procedure combined with in vivo neuronal electrophysiology, we examined the effects of direct THC microinfusions targeting the shell region of the NAc (NASh) and examined how THC may modulate the processing of fear-related emotional memory and concomitant activity states of the mesolimbic DA system. We report that intra-NASh THC dose-dependently potentiates the emotional salience of normally sub-threshold fear-conditioning cues. These effects were dependent upon intra-VTA transmission through GABAergic receptor mechanisms and intra-NASh DAergic transmission. Furthermore, doses of intra-NASh THC that potentiated fear memory salience were found to modulate intra-VTA neuronal network activity by increasing the spontaneous firing and bursting frequency of DAergic neurons whilst decreasing the activity levels of a subpopulation of putative GABAergic VTA neurons. These findings demonstrate that THC can act directly in the NASh to modulate mesolimbic activity states and induce disturbances in emotional salience and memory formation through modulation of VTA DAergic transmission. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Can self-esteem protect against the deleterious consequences of self-objectification for mood and body satisfaction in physically active female university students?

PubMed

Thøgersen-Ntoumani, Cecilie; Ntoumanis, Nikos; Cumming, Jennifer; Bartholomew, Kimberley J; Pearce, Gemma

2011-04-01

Using objectification theory (Fredrickson & Roberts, 1997), this study tested the interaction between self-objectification, appearance evaluation, and self-esteem in predicting body satisfaction and mood states. Participants (N = 93) were physically active female university students. State self-objectification was manipulated by participants wearing tight revealing exercise attire (experimental condition) or baggy exercise clothes (control condition). Significant interactions emerged predicting depression, anger, fatness, and satisfaction with body shape and size. For participants in the self-objectification condition who had low (as opposed to high) appearance evaluation, low self-esteem was associated with high depression, anger, and fatness and low satisfaction with body shape and size. In contrast, for participants with high self-esteem, these mood and body satisfaction states were more favorable irrespective of their levels of appearance evaluation. For female exercisers, self-esteem-enhancing strategies may protect against some of the negative outcomes of self-objectification.

National Management Measures to Control Nonpoint Source Pollution from Forestry

EPA Pesticide Factsheets

This report helps forest owners protect lakes and streams from polluted runoff that can result from forestry activities. The report will also help states to implement their nonpoint source control programs.

78 FR 38041 - Agency Information Collection Activities; Submission for OMB review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

...: Craig Tregillus, Attorney, Division of Marketing Practices, Bureau of Consumer Protection, Federal Trade... Social Security number, date of birth, driver's license number or other state identification number or...

Creep fatigue life prediction for engine hot section materials (ISOTROPIC)

NASA Technical Reports Server (NTRS)

Nelson, R. S.; Schoendorf, J. F.; Lin, L. S.

1986-01-01

The specific activities summarized include: verification experiments (base program); thermomechanical cycling model; multiaxial stress state model; cumulative loading model; screening of potential environmental and protective coating models; and environmental attack model.

Toward Empirical Estimation of the Total Value of Protecting Rivers

NASA Astrophysics Data System (ADS)

Sanders, Larry D.; Walsh, Richard G.; Loomis, John B.

1990-07-01

The purpose of this paper is to develop and apply a procedure to estimate a statistical demand function for the protection of rivers in the Rocky Mountains of Colorado. Other states and nations around the world face a similar problem of estimating how much they can afford to pay for the protection of rivers. The results suggest that in addition to the direct consumption benefits of onsite recreation, total value includes offsite consumption of the flow of information about these activities and resources consumed as preservation benefits. A sample of the general population of the state reports a willingness to pay rather than forego both types of utility. We recommended that offsite values be added to the value of onsite recreation use to determine the total value of rivers to society.

Solid state fermentation of Trichoderma viride for enhancement phenolic content, antioxidant and antimicrobial activities in ginger.

PubMed

Saleh, Rashad M; Kabli, Saleh A; Al-Garni, Saleh M; Al-Ghamdi, Maryam A; Abdel-Aty, Azza M; Mohamed, Saleh A

2018-05-04

The phenolic content of methanolic and water extracts of ginger fermented by Trichoderma spp. during solid state fermentation (SSF) was detected as compared with unfermented ginger. The total phenolic content of fermented ginger increased several times. The highest phenolic content of ginger was detected after SSF by T. viride. The optimal physiological conditions for the maximum production of the phenolic content and β-glucosidase activity of fermented ginger by T. viride were detected at day 7 incubation, pH 6.0, 30°C and 30% moisture. There are consistent between the maximum production of β-glucosidase and phenolic content. The SSF of ginger by T. viride greatly enhanced the antioxidant potency of phenolic compounds by using DPPH and ABTS assays. Potent antibacterial activity was appeared by phenolic compounds of fermented ginger against all the tested human-pathogenic bacteria. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.

PubMed

Meliopoulos, Victoria A; Van de Velde, Lee-Ann; Van de Velde, Nicholas C; Karlsson, Erik A; Neale, Geoff; Vogel, Peter; Guy, Cliff; Sharma, Shalini; Duan, Susu; Surman, Sherri L; Jones, Bart G; Johnson, Michael D L; Bosio, Catharine; Jolly, Lisa; Jenkins, R Gisli; Hurwitz, Julia L; Rosch, Jason W; Sheppard, Dean; Thomas, Paul G; Murray, Peter J; Schultz-Cherry, Stacey

2016-08-01

The healthy lung maintains a steady state of immune readiness to rapidly respond to injury from invaders. Integrins are important for setting the parameters of this resting state, particularly the epithelial-restricted αVβ6 integrin, which is upregulated during injury. Once expressed, αVβ6 moderates acute lung injury (ALI) through as yet undefined molecular mechanisms. We show that the upregulation of β6 during influenza infection is involved in disease pathogenesis. β6-deficient mice (β6 KO) have increased survival during influenza infection likely due to the limited viral spread into the alveolar spaces leading to reduced ALI. Although the β6 KO have morphologically normal lungs, they harbor constitutively activated lung CD11b+ alveolar macrophages (AM) and elevated type I IFN signaling activity, which we traced to the loss of β6-activated transforming growth factor-β (TGF-β). Administration of exogenous TGF-β to β6 KO mice leads to reduced numbers of CD11b+ AMs, decreased type I IFN signaling activity and loss of the protective phenotype during influenza infection. Protection extended to other respiratory pathogens such as Sendai virus and bacterial pneumonia. Our studies demonstrate that the loss of one epithelial protein, αVβ6 integrin, can alter the lung microenvironment during both homeostasis and respiratory infection leading to reduced lung injury and improved survival.

Importance of Carolina Bays to the Avifauna of Pinelands in the Southeastern United States

Treesearch

Stephen Czapka; John Kilgo

2011-01-01

Past anthropogenic activity has led to the destruction or alteration of Carolina bay wetlands throughout the southeastern United States. Presently, urban development, combined with a 2001 ruling by the US Supreme Court relaxing protection of isolated wetlands, poses an increasing threat to these and other isolated wetland systems; however, little information exists on...

Family Forestland Owners of the Lake States:Timber Harvest Activities and Implications for Sustainable Forest Management

Treesearch

Earl C. Leatherberry

2003-01-01

There are an estimated 21.1 million hectares of forestland in Michigan, Wisconsin, and Minnesota--the Lake States. These lands provide benefits such as timber products, wildlife habitat, recreation opportunity, and watershed protection. Land managers, particularly managers of public forestlands, often have strategies to ensure that the values provided are not...

75 FR 47646 - Idaho State University; Notice of Issuance of Director's Decision

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... detector from the reactor core. In the petition Dr. Crawford states that this was cited as an Apparent... detector. The personnel roof access hatch was also addressed in Rev. 3 and Rev. 4 of the Physical Security... procedures to wear protective clothing to routinely remove the activated startup channel detector from the...

National wildlife refuge management on the United States/Mexico border

Treesearch

William R. Radke

2013-01-01

Many conservation strategies have been developed by the U.S. Fish and Wildlife Service in cooperation with others to protect habitat and enhance the recovery of fish and wildlife populations in the San Bernardino Valley, which straddles Arizona, United States, and Sonora, Mexico. Habitats along this international border have been impacted by illegal activities,...

12 CFR 208.85 - Where insurance activities may take place.

Code of Federal Regulations, 2010 CFR

2010-01-01

... SYSTEM MEMBERSHIP OF STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE SYSTEM (REGULATION H) Consumer Protection in Sales of Insurance § 208.85 Where insurance activities may take place. (a) General rule. A bank... transactions are routinely conducted in the bank may refer a consumer who seeks to purchase an insurance...

Estrogen Receptor α Deficiency Modulates TLR Ligand-Mediated PDC-TREM Expression in Plasmacytoid Dendritic Cells in Lupus-Prone Mice.

PubMed

Scott, Jennifer L; Cunningham, Melissa A; Naga, Osama S; Wirth, Jena R; Eudaly, Jackie G; Gilkeson, Gary S

2015-12-15

Female lupus-prone NZM2410 estrogen receptor α (ERα)-deficient mice are protected from renal disease and have prolonged survival compared with wild-type littermates; however, the mechanism of protection is unknown. Plasmacytoid dendritic cells (pDCs) and type I IFN drive lupus pathogenesis. Estrogen acting via ERα enhances both pDC development and IFN production. The objectives for this study were to determine if ERα modulates pDC function and IFN activity in predisease NZM2410 mice as a possible protective mechanism of ERα deficiency in lupus-prone mice. We measured the effect of ERα deficiency on spleen pDC frequency, number, maturation, and activation state. ERα deficiency reduced type I IFN activity and the frequency of MHC class II(+) pDCs in the spleen without altering overall pDC frequency, number, or maturation state. Additionally, ERα-deficient NZM2410 mice had a significantly decreased frequency of pDCs expressing PDC-TREM, a modulator of TLR-mediated IFN production. After in vitro TLR9 stimulation, ERα deficiency significantly reduced the expression of PDC-TREM on pDCs from both NZM2410 and C57BL/6 mice. Thus, we have identified a significant effect of ERα deficiency on pDCs in predisease NZM2410 mice, which may represent a mechanism by which ERα deficiency protects NZM2410 mice from lupuslike disease. Copyright © 2015 by The American Association of Immunologists, Inc.

Estrogen receptor alpha deficiency modulates TLR ligand mediated PDC-TREM expression in plasmacytoid dendritic cells in lupus prone mice

PubMed Central

Scott, Jennifer L; Cunningham, Melissa A; Naga, Osama S; Wirth, Jena R; EuDaly, Jackie G; Gilkeson, Gary S

2016-01-01

Female lupus prone NZM2410 estrogen receptor alpha (ERα) deficient mice are protected from renal disease and have prolonged survival compared to wild type (WT) littermates, however the mechanism of protection is unknown. Plasmacytoid dendritic cells (pDCs) and type I interferon (IFN) drive lupus pathogenesis. Estrogen acting via ERα enhances both pDC development and IFN production. The objectives for this study were to determine if ERα modulates pDC function and IFN activity in pre-disease NZM2410 mice as a possible protective mechanism of ERα deficiency in lupus prone mice. We measured the effect of ERα deficiency on spleen pDC frequency, number, maturation, and activation state. ERα deficiency reduced type I IFN activity and the frequency of MHCII+ pDCs in the spleen without altering overall pDC frequency, number, or maturation state. Additionally, ERα deficient NZM2410 mice had a significantly decreased frequency of pDCs expressing PDC-TREM, a modulator of toll-like receptor (TLR) mediated IFN production. After in vitro TLR9 stimulation, ERα deficiency significantly reduced the expression of PDC-TREM on pDCs from both NZM2410 and C57BL/6 mice. Thus, we have identified a significant effect of ERα deficiency on pDCs in pre-disease NZM2410 mice, which may represent a mechanism by which ERα deficiency protects NZM2410 mice from lupus like disease. PMID:26553076

Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms

PubMed Central

Kubin, Leszek

2017-01-01

Upper airway muscles subserve many essential for survival orofacial behaviors, including their important role as accessory respiratory muscles. In the face of certain predisposition of craniofacial anatomy, both tonic and phasic inspiratory activation of upper airway muscles is necessary to protect the upper airway against collapse. This protective action is adequate during wakefulness, but fails during sleep which results in recurrent episodes of hypopneas and apneas, a condition known as the obstructive sleep apnea syndrome (OSA). Although OSA is almost exclusively a human disorder, animal models help unveil the basic principles governing the impact of sleep on breathing and upper airway muscle activity. This article discusses the neuroanatomy, neurochemistry, and neurophysiology of the different neuronal systems whose activity changes with sleep-wake states, such as the noradrenergic, serotonergic, cholinergic, orexinergic, histaminergic, GABAergic and glycinergic, and their impact on central respiratory neurons and upper airway motoneurons. Observations of the interactions between sleep-wake states and upper airway muscles in healthy humans and OSA patients are related to findings from animal models with normal upper airway, and various animal models of OSA, including the chronic-intermittent hypoxia model. Using a framework of upper airway motoneurons being under concurrent influence of central respiratory, reflex and state-dependent inputs, different neurotransmitters, and neuropeptides are considered as either causing a sleep-dependent withdrawal of excitation from motoneurons or mediating an active, sleep-related inhibition of motoneurons. Information about the neurochemistry of state-dependent control of upper airway muscles accumulated to date reveals fundamental principles and may help understand and treat OSA. PMID:27783860

75 FR 19988 - Watercress Darter National Wildlife Refuge, Jefferson County, AL

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... prominent as development activities occur in the city of Bessemer, Alabama. Watercress Darter NWR is a small.... Extensive resource sharing and networking with other protected areas, State and local government agencies...

Prisoners as Living Donors: A Vulnerabilities Analysis.

PubMed

Ross, Lainie Friedman; Thistlethwaite, J Richard

2018-01-01

Although national guidelines exist for evaluating the eligibility of potential living donors and for procuring their informed consent, no special protections or considerations exist for potential living donors who are incarcerated. Human research subject protections in the United States are codified in the Federal Regulations, 45 CFR 46, and special protections are given to prisoners. Living donor transplantation has parallels with human subject research in that both activities are performed with the primary goal of benefiting third parties. In this article, we describe what special considerations should be provided to prisoners as potential living donors using a vulnerabilities approach adapted from the human research subject protection literature.

Application of an Informatics-Based Decision-Making Framework and Process to the Assessment of Radiation Safety in Nanotechnology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoover, Mark D.; Myers, David S.; Cash, Leigh J.

The National Council on Radiation Protection and Measurements (NCRP) has established NCRP Scientific Committee 2-6 to develop a report on the current state of knowledge and guidance for radiation safety programs involved with nanotechnology. Nanotechnology is the understanding and control of matter at the nanoscale, at dimensions between approximately 1 and 100 nanometers, where unique phenomena enable novel applications. While the full report is in preparation, this article presents and applies an informatics-based decision-making framework and process through which the radiation protection community can anticipate that nano-enabled applications, processes, nanomaterials, and nanoparticles are likely to become present or are alreadymore » present in radiation-related activities; recognize specific situations where environmental and worker safety, health, well-being, and productivity may be affected by nano-related activities; evaluate how radiation protection practices may need to be altered to improve protection; control information, interpretations, assumptions, and conclusions to implement scientifically sound decisions and actions; and confirm that desired protection outcomes have been achieved. This generally applicable framework and supporting process can be continuously applied to achieve health and safety at the convergence of nanotechnology and radiation-related activities.« less

Application of an informatics-based decision-making framework and process to the assessment of radiation safety in nanotechnology.

PubMed

Hoover, Mark D; Myers, David S; Cash, Leigh J; Guilmette, Raymond A; Kreyling, Wolfgang G; Oberdörster, Günter; Smith, Rachel; Cassata, James R; Boecker, Bruce B; Grissom, Michael P

2015-02-01

The National Council on Radiation Protection and Measurements (NCRP) established NCRP Scientific Committee 2-6 to develop a report on the current state of knowledge and guidance for radiation safety programs involved with nanotechnology. Nanotechnology is the understanding and control of matter at the nanoscale, at dimensions between ∼1 and 100 nm, where unique phenomena enable novel applications. While the full report is in preparation, this paper presents and applies an informatics-based decision-making framework and process through which the radiation protection community can anticipate that nano-enabled applications, processes, nanomaterials, and nanoparticles are likely to become present or are already present in radiation-related activities; recognize specific situations where environmental and worker safety, health, well-being, and productivity may be affected by nano-related activities; evaluate how radiation protection practices may need to be altered to improve protection; control information, interpretations, assumptions, and conclusions to implement scientifically sound decisions and actions; and confirm that desired protection outcomes have been achieved. This generally applicable framework and supporting process can be continuously applied to achieve health and safety at the convergence of nanotechnology and radiation-related activities.

Application of an Informatics-Based Decision-Making Framework and Process to the Assessment of Radiation Safety in Nanotechnology

DOE PAGES

Hoover, Mark D.; Myers, David S.; Cash, Leigh J.; ...

2015-01-01

The National Council on Radiation Protection and Measurements (NCRP) has established NCRP Scientific Committee 2-6 to develop a report on the current state of knowledge and guidance for radiation safety programs involved with nanotechnology. Nanotechnology is the understanding and control of matter at the nanoscale, at dimensions between approximately 1 and 100 nanometers, where unique phenomena enable novel applications. While the full report is in preparation, this article presents and applies an informatics-based decision-making framework and process through which the radiation protection community can anticipate that nano-enabled applications, processes, nanomaterials, and nanoparticles are likely to become present or are alreadymore » present in radiation-related activities; recognize specific situations where environmental and worker safety, health, well-being, and productivity may be affected by nano-related activities; evaluate how radiation protection practices may need to be altered to improve protection; control information, interpretations, assumptions, and conclusions to implement scientifically sound decisions and actions; and confirm that desired protection outcomes have been achieved. This generally applicable framework and supporting process can be continuously applied to achieve health and safety at the convergence of nanotechnology and radiation-related activities.« less

Encoding quantum information in a stabilized manifold of a superconducting cavity

NASA Astrophysics Data System (ADS)

Touzard, S.; Leghtas, Z.; Mundhada, S. O.; Axline, C.; Reagor, M.; Chou, K.; Blumoff, J.; Sliwa, K. M.; Shankar, S.; Frunzio, L.; Schoelkopf, R. J.; Mirrahimi, M.; Devoret, M. H.

In a superconducting Josephson circuit architecture, we activate a multi-photon process between two modes by applying microwave drives at specific frequencies. This creates a pairwise exchange of photons between a high-Q cavity and the environment. The resulting open dynamical system develops a two-dimensional quasi-energy ground state manifold. Can we encode, protect and manipulate quantum information in this manifold? We experimentally investigate the convergence and escape rates in and out of this confined subspace. Finally, using quantum Zeno dynamics, we aim to perform gates which maintain the state in the protected manifold at all times. Work supported by: ARO, ONR, AFOSR and YINQE.

75 FR 19383 - Agency Information Collection Activities: Proposed Collection; Comment Request; State Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... No. 2020-0031 AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: In compliance.... ICR numbers: EPA ICR No. 2185.04, OMB Control No. 2020-0031. ICR status: This ICR is currently...

Forest fires in Missouri.

Treesearch

Donald A. Haines; William A. Main; John S. Crosby

1973-01-01

Describes factors that contribute to forest fires on two of the State of Missouri's Protection Districts and the Clark National Forest. Includes an analysis of fire cause, annual distribution, weather, and activity by day of week; also discusses multiple-fire day.

ICPP environmental monitoring report CY-1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-01

Summarized in this report are the data collected through Environmental Monitoring programs conducted at the Idaho Chemical Processing Plant (ICPP) by the Environmental Protection Department. The ICPP is responsible for complying with all applicable Federal, State, Local and DOE Rules, Regulations and Orders. Radiological effluent and emissions are regulated by the DOE in accordance with the Derived Concentration Guides (DCGs) as presented in DOE Order 5400.5. The State of Idaho regulates nonradiological waste resulting from the ICPP operations including airborne, liquid, and solid waste. The Environmental Department updated the Quality Assurance (QA) Project Plan for Environmental Monitoring activities during themore » third quarter of 1992. QA activities have resulted in the ICPP`s implementation of the Environmental Protection Agency (EPA) rules and guidelines pertaining to the collection, analyses, and reporting of environmentally related samples. Where no EPA methods for analyses existed for radionuclides, LITCO methods were used.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matlack, K. S.; Abramowitz, H.; Miller, I. S.

About 50 million gallons of high-level mixed waste is currently stored in underground tanks at the United States Department of Energy’s (DOE’s) Hanford site in the State of Washington. The Hanford Tank Waste Treatment and Immobilization Plant (WTP) will provide DOE’s Office of River Protection (ORP) with a means of treating this waste by vitrification for subsequent disposal. The tank waste will be separated into low- and high-activity waste fractions, which will then be vitrified respectively into Immobilized Low Activity Waste (ILAW) and Immobilized High Level Waste (IHLW) products. The ILAW product will be disposed in an engineered facility onmore » the Hanford site while the IHLW product is designed for acceptance into a national deep geological disposal facility for high-level nuclear waste. The ILAW and IHLW products must meet a variety of requirements with respect to protection of the environment before they can be accepted for disposal.« less

Supplement Analysis for the Wildlife Mitigation Program EIS (DOE/EIS-0246/SA-23) - Canby Ferry Conservation Easement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, Shannon C.

2002-05-15

BPA proposes to purchase a conservation easement on approximately 16 acres of the Canby Ferry parcel in Clackamas County, Oregon for the protection of wetland, riparian, and riverine habitats. This project is part of a multi-agency effort to protect Willamette River frontage and to connect existing Oregon State Park lands with recreational trails. Once the conservation easement is finalized, a management plan will be developed for the Canby Ferry parcel and adjacent parcels, including the Fish Eddy parcel and the Molalla State Park parcel. Future management actions on these lands will likely involve wildlife habitat and riparian area enhancement, restoration,more » and preservation activities. This Supplement Analysis covers the acquisition of the Canby Ferry conservation easement only; all proposed management activities (on the Canby Ferry parcel and adjacent parcels) will require additional NEPA analysis prior to implementation.« less

The IAEA’s activities on radiation protection in interventional cardiology

PubMed Central

Rehani, MM

2007-01-01

The International Atomic Energy Agency (IAEA) under its mandate of developing and applying standards of radiation safety has initiated a number of activities in recent years on radiation protection in interventional cardiology. These activities are implemented through four mechanisms, namely training, providing information through the website, research projects and assistance to Member States through Technical Cooperation (TC) projects. Major international initiatives have been taken in the area of training where more than half a dozen regional training courses have been conducted for cardiologists from over 50 countries. Additionally four national training events for over 300 medical and paramedical staff members involved in interventional procedures were held. The training material is freely available on CD from the IAEA. The newly established website provides information on radiation protection issues [1]. Two coordinated research projects have just been completed where peak skin doses to patients undergoing high dose interventional procedures were studied and factors to manage patient doses were identified. The technical cooperation projects involving protection in cardiac interventional procedures have 30 countries as participants. PMID:21614275

The intrinsically disordered protein LEA7 from Arabidopsis thaliana protects the isolated enzyme lactate dehydrogenase and enzymes in a soluble leaf proteome during freezing and drying.

PubMed

Popova, Antoaneta V; Rausch, Saskia; Hundertmark, Michaela; Gibon, Yves; Hincha, Dirk K

2015-10-01

The accumulation of Late Embryogenesis Abundant (LEA) proteins in plants is associated with tolerance against stresses such as freezing and desiccation. Two main functions have been attributed to LEA proteins: membrane stabilization and enzyme protection. We have hypothesized previously that LEA7 from Arabidopsis thaliana may stabilize membranes because it interacts with liposomes in the dry state. Here we show that LEA7, contrary to this expectation, did not stabilize liposomes during drying and rehydration. Instead, it partially preserved the activity of the enzyme lactate dehydrogenase (LDH) during drying and freezing. Fourier-transform infrared (FTIR) spectroscopy showed no evidence of aggregation of LDH in the dry or rehydrated state under conditions that lead to complete loss of activity. To approximate the complex influence of intracellular conditions on the protective effects of a LEA protein in a convenient in-vitro assay, we measured the activity of two Arabidopsis enzymes (glucose-6-P dehydrogenase and ADP-glucose pyrophosphorylase) in total soluble leaf protein extract (Arabidopsis soluble proteome, ASP) after drying and rehydration or freezing and thawing. LEA7 partially preserved the activity of both enzymes under these conditions, suggesting its role as an enzyme protectant in vivo. Further FTIR analyses indicated the partial reversibility of protein aggregation in the dry ASP during rehydration. Similarly, aggregation in the dry ASP was strongly reduced by LEA7. In addition, mixtures of LEA7 with sucrose or verbascose reduced aggregation more than the single additives, presumably through the effects of the protein on the H-bonding network of the sugar glasses. Copyright © 2015 Elsevier B.V. All rights reserved.

17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells.

PubMed

Urata, Yoshishige; Ihara, Yoshito; Murata, Hiroaki; Goto, Shinji; Koji, Takehiko; Yodoi, Junji; Inoue, Satoshi; Kondo, Takahito

2006-05-12

The GSH/glutaredoxin (GRX) system is involved in the redox regulation of certain enzyme activities, and this system protects cells from H2O2-induced apoptosis by regulating the redox state of Akt (Murata, H., Ihara, Y., Nakamura, H., Yodoi, J., Sumikawa, K., and Kondo, T. (2003) J. Biol. Chem. 278, 50226-50233). Estrogens, such as 17beta-estradiol (E2), play an important role in development, growth, and differentiation and appear to have protective effects on oxidative stress mediated by estrogen receptor alpha (ERalpha). However, the role of the ERbeta-mediated pathway in this cytoprotection and the involvement of E2 in the redox regulation are not well understood. In the present study, we demonstrated that E2 protected cardiac H9c2 cells, expressing ERbeta from H2O2-induced apoptosis concomitant with an increase in the activity of Akt. E2 induced the expression of glutaredoxin (GRX) as well as gamma-glutamylcysteine synthetase, a rate-limiting enzyme for the synthesis of GSH. Inhibitors for both gamma-glutamylcysteine synthetase and GRX and ICI182,780, a specific inhibitor of ERs, abolished the protective effect of E2 on cell survival as well as the activity of Akt, suggesting that ERbeta is involved in the cytoprotection and redox regulation by E2. Transcription of the GRX gene was enhanced by E2. The promoter activity of GRX was up-regulated by an ERbeta-dependent element. These results suggest that the GRX/GSH system is involved in the cytoprotective and genomic effects of E2 on the redox state of Akt, a pathway that is mediated, at least in part, by ERbeta. This mechanism may also play an antiapoptotic role in cancer cells during carcinogenesis or chemotherapy.

Rare & Endangered Species: Understanding Our Disappearing Plants and Animals. Activities Guide.

ERIC Educational Resources Information Center

American Gas Association, Arlington, VA. Educational Services.

About 464 plants and animals found in the United States and its territories are listed by the U.S. Fish and Wildlife Service as threatened or endangered. Another 3900 are candidates for protection. The activities in this guide are designed to help teachers and students understand the issue of endangered species. It includes ideas for several…

75 FR 13127 - Lead-Based Paint Renovation, Repair and Painting Activities in Target Housing and Child Occupied...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... ENVIRONMENTAL PROTECTION AGENCY [EPA-R07-OPPT-2010-0155; FRL-9128-4] Lead-Based Paint Renovation, Repair and Painting Activities in Target Housing and Child Occupied Facilities; State of Iowa. Notice of... target housing and child-occupied facilities: 1. Establish the discipline of lead-safe renovator. 2...

Asbestos worker protection. Environmental Protection Agency (EPA). Final rule.

PubMed

2000-11-15

In this Final Rule, EPA is amending both the Asbestos Worker Protection Rule (WPR) and the Asbestos-in-Schools Rule. The WPR amendment protects State and local government employees from the health risks of exposure to asbestos to the same extent as private sector workers by adopting for these employees the Asbestos Standards of the Occupational Safety and Health Administration (OSHA). The WPR's coverage is extended to State and local government employees who are performing construction work, custodial work, and automotive brake and clutch repair work. This final rule cross-references the OSHA Asbestos Standards for Construction and for General Industry, so that future amendments to these OSHA standards are directly and equally effective for employees covered by the WPR. EPA also amends the Asbestos-in-Schools Rule to provide coverage under the WPR for employees of public local education agencies who perform operations, maintenance, and repair activities. EPA is issuing this final rule under section 6 of the Toxic Substances Control Act (TSCA).

Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II.

PubMed

Monillas, Elizabeth S; Caplan, Jeffrey L; Thévenin, Anastasia F; Bahnson, Brian J

2015-05-01

The intracellular enzyme platelet-activating factor acetylhydrolase type-II (PAFAH-II) hydrolyzes platelet-activating factor and oxidatively fragmented phospholipids. PAFAH-II in its resting state is mainly cytoplasmic, and it responds to oxidative stress by becoming increasingly bound to endoplasmic reticulum and Golgi membranes. Numerous studies have indicated that this enzyme is essential for protecting cells from oxidative stress induced apoptosis. However, the regulatory mechanism of the oxidative stress response by PAFAH-II has not been fully resolved. Here, changes to the oligomeric state of human PAFAH-II were investigated as a potential regulatory mechanism toward enzyme trafficking. Native PAGE analysis in vitro and photon counting histogram within live cells showed that PAFAH-II is both monomeric and dimeric. A Gly-2-Ala site-directed mutation of PAFAH-II demonstrated that the N-terminal myristoyl group is required for homodimerization. Additionally, the distribution of oligomeric PAFAH-II is distinct within the cell; homodimers of PAFAH-II were localized to the cytoplasm while monomers were associated to the membranes of the endoplasmic reticulum and Golgi. We propose that the oligomeric state of PAFAH-II drives functional protein trafficking. PAFAH-II localization to the membrane is critical for substrate acquisition and effective oxidative stress protection. It is hypothesized that the balance between monomer and dimer serves as a regulatory mechanism of a PAFAH-II oxidative stress response. Copyright © 2015 Elsevier B.V. All rights reserved.

The Supreme Court's spring term: abortion, the right to die, and the decline of privacy rights.

PubMed

Wing, K R

1990-01-01

Wing analyzes the constitutional significance and the important long-term implications for health policy of three 1990 U.S. Supreme Court decisions: Hodgson v. Minnesota, Ohio v. Akron Center for Reproductive Health, and Cruzan v. Director, Missouri Department of Health. Hodgson and Ohio upheld state statutes requiring parental notification of a minor's impending abortion. Cruzan upheld a state court decision refusing to allow the family of a patient in a persistent vegetative state to discontinue life-sustaining treatment. Wing argues that these decisions reach far beyond "the abortion issue" or "the right to die." Not only have they narrowed the constitutional protection of individual privacy, but they allow states to regulate activities like abortion in a manner that indicates that the Court is prepared to repeal the notion that individual privacy is entitled to enhanced judicial protection.

76 FR 66940 - Privacy Act of 1974; Department of Homeland Security/United States Secret Service-004 Protection...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

..., private institutions and persons concerning individuals who, because of their activities, personality traits, criminal or mental history, or history of social deviancy, may be of interest to the USSS in...

PROTECTING BIODIVERSITY

EPA Science Inventory

At present, over 40% of the earth's land surface has been converted from its natural state to one dominated by human activities such as agriculture and development. The destruction and degradation of natural habitats has been clearly linked to the loss of biodiversity. Biodiver...

EFFECT OF GROUND-WATER REMEDIATION ACTIVITIES ON INDIGENOUS MICROFLORA

EPA Science Inventory

The United States Environmental Protection Agency (EPA), working with the Interagency DNAPL Consortium, completed an independent evaluation of microbial responses to ground-water remediation technology demonstrations at Launch Pad 34 at Cape Canaveral Air Station in Brevard Count...

50 CFR 224.104 - Special requirements for fishing activities to protect endangered sea turtles.

Code of Federal Regulations, 2010 CFR

2010-10-01

... endangered sea turtles. (a) Shrimp fishermen in the southeastern United States and the Gulf of Mexico who... to civil penalties under the Act for incidental captures of endangered sea turtles by shrimp trawl...

EVALUATING EXCESS DIETARY EXPOSURE OF YOUNG CHILDREN EATING IN CONTAMINATED ENVIRONMENTS

EPA Science Inventory

The United States' Food Quality Protection Act of 1996 requires more accurate assessment of children's aggregate exposures to environmental contaminants. Since children have unstructured eating behaviors, their excess exposures, caused by eating activities, becomes an importan...

Environmental Assessment for Construction/Replacement Military Family Housing- Phase 5 MacDill AFB, Florida

DTIC Science & Technology

2003-12-01

Action can be divided into demolition activities and construction activities. Demolition activities would include the complete removal of 13 multi...that protects those most affected by noise and that can often be achieved on a practical basis. Base activities that have the highest potential...Family Housing – Phase V MacDill AFB, Florida has been approved by the state and Federal fish and wildlife agencies. Land use on MacDill AFB

Injury prevention: where do we go from here?

PubMed

Vinger, P F

1999-02-01

Most eye injuries are preventable. Military personnel, workers, athletes, and other spectacle wearers--especially children and the functionally one-eyed--who require protection from impact, should expect that safety eye-wear actually protects. To present to eye care professionals the current state-of-the-art in eye injury prevention. A review of the current eye protection standards, guidelines, and warnings for the activities of daily living, work, hobbies, education, and sports with emphasis on the importance of standards and the role of the recently organized Protective Eyewear Certification Council (PECC). The prescriber and dispenser are obliged to prescribe, fabricate, and dispense safe and effective eyewear. PECC will help the eye care professional fulfill this obligation.

Improving radioactive waste management: an overview of the Environmental Protection Agency's low-activity waste effort.

PubMed

Schultheisz, Daniel J; Czyscinski, Kenneth S; Klinger, Adam D

2006-11-01

Radioactive waste disposal in the United States is marked by a fragmented regulatory system, with requirements that often focus on the origin or statutory definition of the waste, rather than the hazard of the material in question. It may be possible to enhance public protection by moving toward a system that provides disposal options appropriate for the hazard presented by the waste in question. This paper summarizes aspects of an approach focusing on the potential use, with appropriate conditions, of Resource Conservation and Recovery Act Subtitle-C hazardous waste landfills for disposal of "low-activity" wastes and public comments on the suggested approach.

Oxygen transfer rate identifies priming compounds in parsley cells.

PubMed

Schilling, Jana Viola; Schillheim, Britta; Mahr, Stefan; Reufer, Yannik; Sanjoyo, Sandi; Conrath, Uwe; Büchs, Jochen

2015-11-25

In modern agriculture, the call for an alternative crop protection strategy increases because of the desired reduction of fungicide and pesticide use and the continuously evolving resistance of pathogens and pests to agrochemicals. The direct activation of the plant immune system does not provide a promising plant protection measure because of high fitness costs. However, upon treatment with certain natural or synthetic compounds, plant cells can promote to a fitness cost-saving, primed state of enhanced defense. In the primed state, plants respond to biotic and abiotic stress with faster and stronger activation of defense, and this is often associated with immunity and abiotic stress tolerance. Until now, the identification of chemical compounds with priming-inducing activity (so-called plant activators) relied on tedious and invasive approaches, or required the late detection of secreted furanocoumarin phytoalexins in parsley cell cultures. Thus, simple, fast, straightforward, and noninvasive techniques for identifying priming-inducing compounds for plant protection are very welcome. This report demonstrates that a respiration activity-monitoring system (RAMOS) can identify compounds with defense priming-inducing activity in parsley cell suspension in culture. RAMOS relies on the quasi-continuous, noninvasive online determination of the oxygen transfer rate (OTR). Treatment of parsley culture cells with the known plant activator salicylic acid (SA), a natural plant defense signal, resulted in an OTR increase. Addition of the defense elicitor Pep13, a cell wall peptide of Phythophthora sojae, induced two distinctive OTR peaks that were higher in SA-primed cells than in unprimed cells upon Pep13 challenge. Both, the OTR increase after priming with SA and the Pep13 challenge were dose-dependent. Furthermore, there was a close correlation of a compound's activity to enhance the oxygen consumption in parsley cells and its capacity to prime Pep13-induced furanocoumarin secretion as evaluated by fluorescence spectroscopy. RAMOS noninvasively determines the OTR as a measure of the metabolic activity of plant cells. Chemical enhancement of oxygen consumption by salicylic derivatives in parsley cell suspension cultures correlates with the induction of the primed state of enhanced defense that enhances the quantity of Pep13-induced furanocoumarin phytoalexins. Treatment with the priming-active compounds methyl jasmonate and pyraclostrobin also resulted in an enhanced respiration activity. Thus, RAMOS is a novel technology for identifying priming-inducing compounds for agriculture.

Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine

PubMed Central

Coats, Stephen R.; Hashim, Ahmed; Paramonov, Nikolay A.; Curtis, Michael A.

2016-01-01

ABSTRACT Intestinal homeostasis mechanisms must protect the host intestinal tissue from endogenous lipopolysaccharides (LPSs) produced by the intestinal microbiota. In this report, we demonstrate that murine intestinal fecal lipids effectively block Toll-like receptor 4 (TLR4) responses to naturally occurring Bacteroidetes sp. LPS. Cardiolipin (CL) represents a significant proportion of the total intestinal and fecal lipids and, furthermore, potently antagonizes TLR4 activation by reducing LPS binding at the lipopolysaccharide binding protein (LBP), CD14, and MD-2 steps of the TLR4 signaling pathway. It is further demonstrated that intestinal lipids and CL are less effective at neutralizing more potent Enterobacteriaceae-type LPS, which is enriched in feces obtained from mice with dextran sodium sulfate (DSS)-treated inflammatory bowel disease. The selective inhibition of naturally occurring LPS structures by intestinal lipids may represent a novel homeostasis mechanism that blocks LPS activation in response to symbiotic but not dysbiotic microbial communities. IMPORTANCE The guts of animals harbor a variety of Gram-negative bacteria associated with both states of intestinal health and states of disease. Environmental factors, such as dietary habits, can drive the microbial composition of the host animal's intestinal bacterial community toward a more pathogenic state. Both beneficial and harmful Gram-negative bacteria are capable of eliciting potentially damaging inflammatory responses from the host intestinal tissues via a lipopolysaccharide (LPS)-dependent pathway. Physical mucosal barriers and antibodies produced by the intestinal immune system protect against the undesired inflammatory effects of LPS, although it is unknown why some bacteria are more effective at overcoming the protective barriers than others. This report describes the discovery of a lipid-type protective barrier in the intestine that reduces the deleterious effects of LPSs from beneficial bacteria but is less effective in dampening the inflammatory effects of LPSs from harmful bacteria, providing a novel mechanistic insight into inflammatory intestinal disorders. PMID:27208127

Hypothyroidism and oxidative stress: differential effect on the heart of virgin and pregnant rats.

PubMed

Carmona, Y V; Coria, M J; Oliveros, L B; Gimenez, M S

2014-01-01

The present study investigates the effects of hypothyroidism on both the redox state and the thyroid hormone receptors expression in the heart ventricle of virgin and pregnant rats.Hypothyroid state was induced by 6-n-propyl-2-thiouracil in drinking water given to Wistar rats starting 8 days before mating until day 21 of pregnancy or for 30 days in virgin rats. Serum paraoxonase-1 (PON-1) activity, serum and heart nitrites, and thiobarbituric acid-reactive substances (TBARS) were analyzed. Heart protein oxidation, as carbonyls, and copper-zinc superoxide dismutase (CuZnSOD), glutathione peroxidase (GPx), and catalase (CAT) activities, were determined. In addition, heart expressions of NADPH oxidase (NOX-2), CAT, SOD, GPx, and thyroid receptors (TRα and TRβ) mRNA were assessed by RT-PCR. Inducible and endothelial Nitric Oxide Synthase (iNOS and eNOS) were determined by Western blot. Hypothyroidism in the heart of virgin rats decreased TRα and TRβ expressions, and induced oxidative stress, leading to a decrease of nitrites and an increase of carbonyls, NOX-2 mRNA, and GPx activity. A decreased PON-1 activity suggested low protection against oxidative stress in blood circulation. Pregnancy reduced TRα and TRβ mRNA expressions and induced oxidative stress by increasing nitrite and TBARS levels, SOD and CAT activities and NOX-2, eNOS and iNOS expressions, while hypothyroidism, emphasized the decreases of TRα mRNA levels and did not alter the redox state in the heart. TR expressions and redox balance of rat hearts depend on the physiological state. Pregnancy per se seems to protect the heart against oxidative stress induced by hypothyroidism. Supporting Information for this article is available online at http://www.thieme-connect.de/ejournals/toc/hmr. © Georg Thieme Verlag KG Stuttgart · New York.

7 CFR 624.5 - Coordination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.5 Coordination. (a) If the President declares... Presidentially-declared natural disasters. (b) When an NRCS State Conservationist determines that a watershed... agencies involved with emergency activities, as appropriate. (c) In the case where the watershed impairment...

7 CFR 624.5 - Coordination.

Code of Federal Regulations, 2012 CFR

2012-01-01

... AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.5 Coordination. (a) If the President declares... Presidentially-declared natural disasters. (b) When an NRCS State Conservationist determines that a watershed... agencies involved with emergency activities, as appropriate. (c) In the case where the watershed impairment...

7 CFR 624.5 - Coordination.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.5 Coordination. (a) If the President declares... Presidentially-declared natural disasters. (b) When an NRCS State Conservationist determines that a watershed... agencies involved with emergency activities, as appropriate. (c) In the case where the watershed impairment...

ToxCast: Using high throughput screening to identify profiles of biological activity

EPA Science Inventory

ToxCast, the United States Environmental Protection Agency’s chemical prioritization research program, is developing methods for utilizing computational chemistry and bioactivity profiling to predict potential for toxicity and prioritize limited testing resources (www.epa.gov/toc...

Applications of high throughput screening to identify profiles of biological activity

EPA Science Inventory

ToxCast, the United States Environmental Protection Agency’s chemical prioritization research program, is developing methods for utilizing computational chemistry and bioactivity profiling to predict potential for toxicity and prioritize limited testing resources (www.epa.gov/toc...

45 CFR 261.70 - What safeguards are there to ensure that participants in work activities do not displace other...

Code of Federal Regulations, 2010 CFR

2010-10-01

... complaints of alleged violations of the displacement rule in this section. (c) This section does not preempt or supersede State or local laws providing greater protection for employees from displacement. ...

45 CFR 261.70 - What safeguards are there to ensure that participants in work activities do not displace other...

Code of Federal Regulations, 2014 CFR

2014-10-01

... complaints of alleged violations of the displacement rule in this section. (c) This section does not preempt or supersede State or local laws providing greater protection for employees from displacement. ...

45 CFR 261.70 - What safeguards are there to ensure that participants in work activities do not displace other...

Code of Federal Regulations, 2013 CFR

2013-10-01

... complaints of alleged violations of the displacement rule in this section. (c) This section does not preempt or supersede State or local laws providing greater protection for employees from displacement. ...

45 CFR 261.70 - What safeguards are there to ensure that participants in work activities do not displace other...

Code of Federal Regulations, 2012 CFR

2012-10-01

... complaints of alleged violations of the displacement rule in this section. (c) This section does not preempt or supersede State or local laws providing greater protection for employees from displacement. ...

45 CFR 261.70 - What safeguards are there to ensure that participants in work activities do not displace other...

Code of Federal Regulations, 2011 CFR

2011-10-01

... complaints of alleged violations of the displacement rule in this section. (c) This section does not preempt or supersede State or local laws providing greater protection for employees from displacement. ...

The antiaging activity and cerebral protection of rapamycin at micro-doses.

PubMed

Qi, Haiyan; Su, Feng-Yun; Wan, Shan; Chen, Yongjie; Cheng, Yan-Qiong; Liu, Ai-Jun

2014-11-01

The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed into an antiaging agent remains unclear. We demonstrated that rapamycin at micro-doses (below the TORC1 inhibiting concentration) exhibits a cell-protective activity: (1) It protects cultured neurons against neurotoxin MPP(+) and H2O2. (2) It increases survival time of neuron in culture. (3) It maintains the nonproliferative state of cultured senescent human fibroblasts and prevents cell death induced by telomere dysfunction. (4) In animal models, it decreased the cerebral infarct sizes induced by acute ischemia and dramatically extended the life span of stroke prone spontaneously hypertensive rats (SHR-SPs). We propose that rapamycin at micro-dose can be developed into an antiaging agent with a novel mechanism. © 2014 John Wiley & Sons Ltd.

Effect of Malathion on the Microbial Ecology of Activated Sludge

DTIC Science & Technology

2015-03-26

EFFECT OF MALATHION ON THE MICROBIAL ECOLOGY OF ACTIVATED SLUDGE THESIS Seth K. Martin, Senior Master Sergeant, USAF AFIT-ENV-MS-15-M-095 DEPARTMENT...Government and is not subject to copyright protection in the United States. AFIT-ENV-MS-15-M-095 EFFECT OF MALATHION ON THE MICROBIAL ECOLOGY OF ACTIVATED...UNLIMITED. AFIT-ENV-MS-15-M-095 EFFECT OF MALATHION ON THE MICROBIAL ECOLOGY OF ACTIVATED SLUDGE THESIS Seth K. Martin, B.S. Senior Master Sergeant

The protective role of the Bowman-Birk protease inhibitor in soybean lunasin digestion: the effect of released peptides on colon cancer growth.

PubMed

Cruz-Huerta, Elvia; Fernández-Tomé, Samuel; Arques, M Carmen; Amigo, Lourdes; Recio, Isidra; Clemente, Alfonso; Hernández-Ledesma, Blanca

2015-08-01

Lunasin is a naturally-occurring peptide demonstrating chemopreventive, antioxidant and anti-inflammatory properties. To exhibit these activities, orally ingested lunasin needs to survive proteolytic attack of digestive enzymes to reach target tissues in active form/s. Preliminary studies suggested the protective role of protease inhibitors, such as the Bowman-Birk inhibitor and Kunitz-trypsin inhibitor, against lunasin's digestion by both pepsin and pancreatin. This work describes in depth the behaviour of lunasin under conditions simulating the transit through the gastrointestinal tract in the absence or presence of soybean Bowman-Birk isoinhibitor 1 (IBB1) in both active and inactive states. By liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS), the remaining lunasin at the end of gastric and gastro-duodenal phases was quantified. Protection against the action of pepsin was independent of the amount of IBB1 present in the analyzed samples, whereas an IBB1 dose-dependent protective effect against trypsin and chymotrypsin was observed. Peptides released from lunasin and inactive IBB1 were identified by MS/MS. The remaining lunasin and IBB1 as well as their derived peptides could be responsible for the anti-proliferative activity against colon cancer cells observed for the digests obtained at the end of simulated gastrointestinal digestion.

Permeation of Comite through protective gloves.

PubMed

Zainal, Hanaa; Que Hee, Shane S

2006-09-01

The goal of the study was to assess how protective disposable (Safeskin) and chemical protective (Sol-Vex) nitrile gloves were against Comite emulsifiable concentrate formulation containing propargite (PROP) as active pesticidal ingredient, because there were no explicit recommendations for the gloves that should be worn for hand protection. The glove material was exposed in ASTM-type I-PTC-600 permeation cells at 30.0+/-0.5 degrees C, and gas chromatography-mass spectrometry used for PROP analysis. Aqueous solutions of Comite at 40.4 mg/mL permeated both Safeskin and Sol-Vex nitrile by 8h. Safeskin showed a mean PROP mass permeated of 176+/-27 microg after 8h compared with a mean mass permeated for Sol-Vex of 3.17+/-4.08 microg. Thus, Sol-Vex was about 56 times more protective than Safeskin for an 8-h exposure. However, the kinetics of the permeation revealed that Safeskin can be worn for at least 200 min before disposal. When undiluted Comite challenged both types of nitrile, much faster permeation was observed. Safeskin gloves showed two steady state periods. The first had lag times (t(l)) values of about 1h, although normalized breakthrough times (t(b)) were < 10 min. The second steady state rate (P(s)) was on average four times the rate of the first period, and the second steady state period t(l) was about three times as long as that of the first steady state period, and about the same t(l) as for the aqueous solution. Sol-Vex gloves exposed continuously to undiluted Comite permeated above the normalized breakthrough threshold beyond 2.7h. A risk assessment revealed that the PROP skin permeation rate of 7.1 ng cm(-2)h(-1) was much slower than the first steady state Safeskin glove P(s) of 62,000 ng cm(-2)h(-1). Infrared analysis showed that the glove surfaces were not degraded by the Comite challenge. The chemically protective Sol-Vex gloves protected adequately against undiluted formulation for about 2.7h, whereas they provided protection for nearly 8h when the formulation was diluted with water to the highest concentration for field application. In contrast, the disposable Safeskin gloves did not protect at all for the undiluted formulation, but did for 200 min when the formulation was diluted with water to the highest concentration for spraying.

[Legal aspects of prevention. The constitutional principle of optimal health protection].

PubMed

von Wartburg, W P

1978-12-01

With respect to the health services, a State founded upon the rule of law is in duty bound to act with restraint. Its aim should be to guarantee that public health is maintained in optimal fashion. For this purpose it must endeavour to exert an effective influence on environmental factors. The three main categories of activity with which the health services are concerned, i.e. protection of health, promotion of health, and health care should be governed by the principles inherent in a State based upon the rule of law. As regards preventive measures, this means that the State has to shape the environment and society in such a way as to meet the requirements of a modern system for the protection of public health, its objective in this context being to eliminate or minimise health risks. A rational government programme for the promotion of public health must also be designed to promote a more health-conscious pattern of behaviour in the population at large and to encourage those citizens requiring treatment to invoke the aid of the health care services without delay.

Protecting nonlocality of multipartite states by feed-forward control

NASA Astrophysics Data System (ADS)

Li, Xiao-Gang; Zou, Jian; Shao, Bin

2018-06-01

Nonlocality is a useful resource in quantum communication and quantum information processing. In practical quantum communication, multipartite entangled states must be distributed between different users in different places through a channel. However, the channel is usually inevitably disturbed by the environment in quantum state distribution processing and then the nonlocality of states will be weakened and even lost. In this paper, we use a feed-forward control scheme to protect the nonlocality of the Bell and GHZ states against dissipation. We find that this protection scheme is very effective, specifically, for the Bell state, we can increase the noise threshold from 0.5 to 0.98, and for GHZ state from 0.29 to 0.96. And we also find that entanglement is relatively easier to be protected than nonlocality. For our scheme, protecting entanglement is equivalent to protecting the state in the case of Bell state, while protecting nonlocality is not.

Physical activity in Brazil: lessons from ELSA-Brasil. Narrative review.

PubMed

Pitanga, Francisco José Gondim; Almeida, Maria Conceição Chagas; Queiroz, Ciro Oliveira; Aquino, Estela Maria Leão de; Matos, Sheila Maria Alvim

2017-01-01

The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) was conducted among civil servants at six higher education institutions located in six Brazilian state capitals. The objective of this review was to identify the publications produced within the scope of ELSA-Brasil that analyzed the participants' physical activity. Review study using baseline data from ELSA-Brasil. Narrative review of Brazilian studies on physical activity produced using data from ELSA-Brasil participants. The prevalence of leisure-time physical activity (LTPA) among ELSA-Brasil participants was low (44.1% among men and 33.8% among women). The main factors associated were social (higher schooling and family income), environmental (living in places with conditions and opportunities for physical activity) and individual (not being obese, being retired, not smoking and positive perception of body image). The perception of facilities for walking in the neighborhood was positively associated with both LTPA and commuting-related physical activity. An active lifestyle was a protective factor against several cardiometa-bolic variables (hypertension, diabetes, lipid abnormalities and cardiovascular risk over the next 10 years). Comparison between LTPA and commuting-related physical activity showed that only LTPA had a protective effect against arterial hypertension. The prevalence of physical activity among ELSA-Brasil participants was low. The main determinants were social, environmental and personal. LTPA had a greater protective efect on cardio-metabolic outcomes than did commuting-related physical activity.

Epidemiology of infant meningococcal disease in the United States, 2006-2012.

PubMed

MacNeil, Jessica R; Bennett, Nancy; Farley, Monica M; Harrison, Lee H; Lynfield, Ruth; Nichols, Megin; Petit, Sue; Reingold, Arthur; Schaffner, William; Thomas, Ann; Pondo, Tracy; Mayer, Leonard W; Clark, Thomas A; Cohn, Amanda C

2015-02-01

The incidence of meningococcal disease is currently at historic lows in the United States; however, incidence remains highest among infants aged <1 year. With routine use of Haemophilus influenzae type b and pneumococcal vaccines in infants and children in the United States, Neisseria meningitidis remains an important cause of bacterial meningitis in young children. Data were collected from active, population- and laboratory-based surveillance for N meningitidis conducted through Active Bacterial Core surveillance during 2006 through 2012. Expanded data collection forms were completed for infant cases identified in the surveillance area during 2006 through 2010. An estimated 113 cases of culture-confirmed meningococcal disease occurred annually among infants aged <1 year in the United States from 2006 through 2012, for an overall incidence of 2.74 per 100,000 infants. Among these cases, an estimated 6 deaths occurred. Serogroup B was responsible for 64%, serogroup C for 12%, and serogroup Y for 16% of infant cases. Based on the expanded data collection forms, a high proportion of infant cases (36/58, 62%) had a smoker in the household and the socioeconomic status of the census tracts where infant meningococcal cases resided was lower compared with the other Active Bacterial Core surveillance areas and the United States as a whole. The burden of meningococcal disease remains highest in young infants and serogroup B predominates. Vaccines that provide long-term protection early in life have the potential to reduce the burden of meningococcal disease, especially if they provide protection against serogroup B meningococcal disease. Copyright © 2015 by the American Academy of Pediatrics.

Applications of high throughput screening to identify profiles of biological activity relevant to carcinogenesis

EPA Science Inventory

ToxCast, the United States Environmental Protection Agency’s chemical prioritization research program, is developing methods for utilizing computational chemistry and bioactivity profiling to predict potential for toxicity and prioritize limited testing resources (www.epa.gov/toc...

36 CFR 12.2 - Purpose of National Cemeteries.

Code of Federal Regulations, 2011 CFR

2011-07-01

... United States. Such areas are protected, managed and administered as suitable and dignified burial grounds and as significant cultural resources. As such, the authorization of activities that take place in... compatible with maintaining the solemn commemorative and historic character of these areas. ...

36 CFR 12.2 - Purpose of National Cemeteries.

Code of Federal Regulations, 2010 CFR

2010-07-01

... United States. Such areas are protected, managed and administered as suitable and dignified burial grounds and as significant cultural resources. As such, the authorization of activities that take place in... compatible with maintaining the solemn commemorative and historic character of these areas. ...

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY RESEARCH ACTIVITIES TO CHARACTERIZE CHILDREN'S ENVIRONMENTAL EXPOSURES

EPA Science Inventory

Given the well-established vulnerability of children to the effects of environmental exposures and the array of environmental exposures that have not been studied, understanding the relationship between children's health outcomes and environmental exposures is critical for our ...

BATHING BEACH MONITORING PROTOCOLS/COMMUNICATING SWIMMING ACTIVITY RISK TO THE PUBLIC

EPA Science Inventory

Current Environmental Protection Agency (EPA) recommended monitoring practices for bathing beach water quality were suggested in 1968, as a part of the fecal coliform guideline developed by the Federal Water Pollution Control Administration. The guideline stated that five water ...

DISTRIBUTION OF SEDIMENT MERCURY CONCENTRATIONS IN THE HUMBOLDT RIVER WATERSHED

EPA Science Inventory

In 1998 the United States Environmental Protection Agency (USEPA) required the mining industry to list all releases to the environment exceeding the Toxic Release Inventory (TRI) reporting threshold. Mining activities in Arizona, California and Nevada accounted for approx...

The 90-kDa Heat Shock Protein Hsp90 Protects Tubulin against Thermal Denaturation*

PubMed Central

Weis, Felix; Moullintraffort, Laura; Heichette, Claire; Chrétien, Denis; Garnier, Cyrille

2010-01-01

Hsp90 and tubulin are among the most abundant proteins in the cytosol of eukaryotic cells. Although Hsp90 plays key roles in maintaining its client proteins in their active state, tubulin is essential for fundamental processes such as cell morphogenesis and division. Several studies have suggested a possible connection between Hsp90 and the microtubule cytoskeleton. Because tubulin is a labile protein in its soluble form, we investigated whether Hsp90 protects it against thermal denaturation. Both proteins were purified from porcine brain, and their interaction was characterized in vitro by using spectrophotometry, sedimentation assays, video-enhanced differential interference contrast light microscopy, and native polyacrylamide gel electrophoresis. Our results show that Hsp90 protects tubulin against thermal denaturation and keeps it in a state compatible with microtubule polymerization. We demonstrate that Hsp90 cannot resolve tubulin aggregates but that it likely binds early unfolding intermediates, preventing their aggregation. Protection was maximal at a stoichiometry of two molecules of Hsp90 for one of tubulin. This protection does not require ATP binding and hydrolysis by Hsp90, but it is counteracted by geldanamycin, a specific inhibitor of Hsp90. PMID:20110359

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.

PubMed

Morsali, Damineh; Bechtold, David; Lee, Woojin; Chauhdry, Summen; Palchaudhuri, Upayan; Hassoon, Paula; Snell, Daniel M; Malpass, Katy; Piers, Thomas; Pocock, Jennifer; Roach, Arthur; Smith, Kenneth J

2013-04-01

Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple sclerosis, but no therapies are known to be effective in axonal protection. Sodium channel blocking agents can provide effective protection of axons in the white matter in experimental models of multiple sclerosis, but the mechanism of action (directly on axons or indirectly via immune modulation) remains uncertain. Here we have examined the efficacy of two sodium channel blocking agents to protect white matter axons in two forms of experimental autoimmune encephalomyelitis, a common model of multiple sclerosis. Safinamide is currently in phase III development for use in Parkinson's disease based on its inhibition of monoamine oxidase B, but the drug is also a potent state-dependent inhibitor of sodium channels. Safinamide provided significant protection against neurological deficit and axonal degeneration in experimental autoimmune encephalomyelitis, even when administration was delayed until after the onset of neurological deficit. Protection of axons was associated with a significant reduction in the activation of microglia/macrophages within the central nervous system. To clarify which property of safinamide was likely to be involved in the suppression of the innate immune cells, the action of safinamide on microglia/macrophages was compared with that of the classical sodium channel blocking agent, flecainide, which has no recognized monoamine oxidase B activity, and which has previously been shown to protect the white matter in experimental autoimmune encephalomyelitis. Flecainide was also potent in suppressing microglial activation in experimental autoimmune encephalomyelitis. To distinguish whether the suppression of microglia was an indirect consequence of the reduction in axonal damage, or possibly instrumental in the axonal protection, the action of safinamide was examined in separate experiments in vitro. In cultured primary rat microglial cells activated by lipopolysaccharide, safinamide potently suppressed microglial superoxide production and enhanced the production of the anti-oxidant glutathione. The findings show that safinamide is effective in protecting axons from degeneration in experimental autoimmune encephalomyelitis, and that this effect is likely to involve a direct effect on microglia that can result in a less activated phenotype. Together, this work highlights the potential of safinamide as an effective neuroprotective agent in multiple sclerosis, and implicates microglia in the protective mechanism.

Achieving Homeland Security in a Time of Diminishing Resources

DTIC Science & Technology

2012-06-08

and merged over 22 federal agencies and programs under the DHS umbrella. The overall mission of DHS is to enact “ a concerted national effort to ensure... A concerted national effort to prevent terrorist attacks within the United States; reduce America’s vulnerability to terrorism, major disasters...activity or effort performed to protect a nation against attack or other threats National Security. Requirement to maintain the survival of the state

Comparative evaluation of extracellular β-D-fructofuranosidase in submerged and solid-state fermentation produced by newly identified Bacillus subtilis strain.

PubMed

Lincoln, Lynette; More, Sunil S

2018-04-17

To screen and identify a potential extracellular β-D-fructofuranosidase or invertase producing bacterium from soil, and comparatively evaluate the enzyme biosynthesis under submerged and solid-state fermentation. Extracellular invertase producing bacteria were screened from soil. Identification of the potent bacterium was performed based on microscopic examinations and 16S rDNA molecular sequencing. Bacillus subtilis LYN12 invertase secretion was surplus with wheat bran humidified with molasses medium (70%), with elevated activity at 48 h and 37 °C under solid-state fermentation, whereas under submerged conditions increased activity was observed at 24 h and 45 °C in the molasses medium. The study revealed a simple fermentative medium for elevated production of extracellular invertase from a fast growing Bacillus strain. Bacterial invertases are scarce and limited reports are available. By far, this is the first report on the comparative analysis of optimization of extracellular invertase synthesis from Bacillus subtilis strain by submerged and solid-state fermentation. The use of agricultural residues increased yields resulting in development of a cost-effective and stable approach. Bacillus subtilis LYN12 invertase possesses excellent fermenting capability to utilize agro-industrial residues under submerged and solid-state conditions. This could be a beneficial candidate in food and beverage processing industries. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

A Unified Theory of Trust and Collaboration

NASA Astrophysics Data System (ADS)

Cai, Guoray; Squicciarini, Anna

We consider a type of applications where collaboration and trust are tightly coupled with the need to protect sensitive information. Existing trust management technologies have been limited to offering generic mechanisms for enforcing access control policies based on exchanged credentials, and rarely deal with the situated meaning of trust in a specific collaborative context. Towards trust management for highly dynamic and collaborative activities, this paper describes a theory of trust intention and semantics that makes explicit connections between collaborative activities and trust. The model supports inferring trust state based on knowledge about state of collaborative activity. It is the first step towards a unified approach for computer-mediated trust communication in the context of collaborative work.

National Perspectives on Data Protection.

ERIC Educational Resources Information Center

Yurow, Jane

1983-01-01

Discussion of different approaches to protecting personal information in Europe and the United States highlights data protection laws and agreements (international transfer of personal data, European laws, United States state and federal laws), United States and European views of privacy protection, national economic and political goals, and…

Environmental Policy Issues Affecting the United States Army in Its Overseas Activities

DTIC Science & Technology

1989-01-01

1988 Containing Reform: The UK Stance en the European Community environmental impact assessment Directive. Policy and Impact Assessment fi (3, 4): 95...protect the en - ’duainau respect et:::l protection de 1’nviron- in adopting Article 130 R of the Single European Act, adoptant P’article 130 R de l’Acte...struments are not always enforced at national level: mentsjuridiques ratifids ne soient pas toujours mis en application au niveau national: 10

Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1)

PubMed Central

Liu, Xiaobin; Xavier, Christy; Jann, Jamieson; Wu, Hongli

2016-01-01

Protein glutathionylation, defined as the formation of protein mixed disulfides (PSSG) between cysteine residues and glutathione (GSH), can lead to cell death. Glutaredoxin 1 (Grx1) is a thiol repair enzyme which catalyzes the reduction of PSSG. Therefore, Grx1 exerts strong anti-apoptotic effects by improving the redox state, especially in times of oxidative stress. However, there is currently no compound that is identified as a Grx1 activator. In this study, we identified and characterized Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury. Our results showed that treatment with Sal B protected primary human RPE cells from H2O2-induced cell damage. Interestingly, we found Sal B pretreatment upregulated Grx1 expression in RPE cells in a time- and dose-dependent manner. Furthermore, NF-E2-related factor 2 (Nrf2), the key transcription factor that regulates the expression of Grx1, was activated in Sal B treated RPE cells. Further investigation showed that knockdown of Grx1 by small interfering RNA (siRNA) significantly reduced the protective effects of Sal B. We conclude that Sal B protects RPE cells against H2O2-induced cell injury through Grx1 induction by activating Nrf2 pathway, thus preventing lethal accumulation of PSSG and reversing oxidative damage. PMID:27827892

Distributed Localization of Active Transmitters in a Wireless Sensor Network

DTIC Science & Technology

2012-03-01

Distributed Localization of Active Transmitters in a Wireless Sensor Network THESIS Oba L. Vincent, 2nd Lieutenant, USAF AFIT/GE/ENG/12-41 DEPARTMENT...protection in the United States. AFIT/GE/ENG/12-41 Distributed Localization of Active Transmitters in a Wireless Sensor Network THESIS Presented to the...Transmitters in a Wireless Sensor Network Oba L. Vincent, B.S.E.E. 2nd Lieutenant, USAF Approved: /signed/ 29 Feb 2012 Maj. Mark D. Silvius, Ph.D. (Chairman

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2012 CFR

2012-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2012-10-01 2012-10-01 false Designated State Protection and Advocacy agency...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2013 CFR

2013-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2013-10-01 2013-10-01 false Designated State Protection and Advocacy agency...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2011 CFR

2011-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2011-10-01 2011-10-01 false Designated State Protection and Advocacy agency...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2014 CFR

2014-10-01

... DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection... 45 Public Welfare 4 2014-10-01 2014-10-01 false Designated State Protection and Advocacy agency...

14 CFR 413.13 - Complete application.

Code of Federal Regulations, 2013 CFR

2013-01-01

... information required by this chapter, the FAA requires other information necessary for a determination that public health and safety, safety of property, and national security and foreign policy interests of the United States are protected during the conduct of a licensed or permitted activity, an applicant must...

14 CFR 413.13 - Complete application.

Code of Federal Regulations, 2012 CFR

2012-01-01

... information required by this chapter, the FAA requires other information necessary for a determination that public health and safety, safety of property, and national security and foreign policy interests of the United States are protected during the conduct of a licensed or permitted activity, an applicant must...

29 CFR 553.214 - Trainees.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., constitutes engagement in activities under section 7(k) only when the employee meets all the applicable tests... FAIR LABOR STANDARDS ACT TO EMPLOYEES OF STATE AND LOCAL GOVERNMENTS Fire Protection and Law Enforcement Employees of Public Agencies Exemption Requirements § 553.214 Trainees. The attendance at a bona...

29 CFR 553.214 - Trainees.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., constitutes engagement in activities under section 7(k) only when the employee meets all the applicable tests... FAIR LABOR STANDARDS ACT TO EMPLOYEES OF STATE AND LOCAL GOVERNMENTS Fire Protection and Law Enforcement Employees of Public Agencies Exemption Requirements § 553.214 Trainees. The attendance at a bona...

78 FR 12141 - Proposed Agency Information Collection Activities; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... Bureau to monitor consumers' behavior--specifically, consumer use of deposit accounts as transactional... of Consumer Financial Protection (Bureau), and state supervisors of banks and savings associations... consumer customers compared to business customers, and [cir] For those institutions with $1 billion or more...

Some legal aspects of genetic screening.

PubMed

Abbing, H R

2003-01-01

Screening activities in health care are not always useful and sometimes harmful. The mere offer of a screening test puts the individual's autonomy under constraint. With genetic (predictive and risk assessment) tests, the right to free, informed consent and to protection of privacy and medical confidentiality is even more warranted. Screening evokes many questions from the perspective of the right to health care as well as (in particular with genetic screening) from the perspective of respect for individual human rights. Fear of liability puts pressure on professional restraint not to offer every screening test available. States have to take legislative measures for guaranteeing that only those screening activities become available that can significantly contribute to individual and public health. They also should consider additional rules for protecting individual rights where those that are generally accepted in the "ordinary" medical setting (the individual patient-doctor relationship), offer insufficient protection.

Valence tautomerism in synthetic models of cytochrome P450

PubMed Central

Das, Pradip Kumar; Samanta, Subhra; McQuarters, Ashley B.; Lehnert, Nicolai

2016-01-01

CytP450s have a cysteine-bound heme cofactor that, in its as-isolated resting (oxidized) form, can be conclusively described as a ferric thiolate species. Unlike the native enzyme, most synthetic thiolate-bound ferric porphyrins are unstable in air unless the axial thiolate ligand is sterically protected. Spectroscopic investigations on a series of synthetic mimics of cytP450 indicate that a thiolate-bound ferric porphyrin coexists in organic solutions at room temperature (RT) with a thiyl-radical bound ferrous porphyrin, i.e., its valence tautomer. The ferric thiolate state is favored by greater enthalpy and is air stable. The ferrous thiyl state is favored by entropy, populates at RT, and degrades in air. These ground states can be reversibly interchanged at RT by the addition or removal of water to the apolar medium. It is concluded that hydrogen bonding and local electrostatics protect the resting oxidized cytP450 active site from degradation in air by stabilizing the ferric thiolate ground state in contrast to its synthetic analogs. PMID:27302948

The accession countries benefit in the field of plant protection products.

PubMed

Stanek, A

2004-04-01

Ten candidate countries are expected to join EU in 2004. In the field of plant protection product (PPP) regulation, at EU level, acceding states will have roles in evaluation for listing of active substances in Annex I of Directive 91/414/EEC and ensuring that at national level, regulatory procedures comply with the acquis communautaire. This paper briefly outlines the impact of the acquis on the roles of Member States at both EU and national levels. It then briefly explains the current Czech Republic regulatory system as operated by the State Phytosanitary Administration and the National Institute of Public Health and the steps that the Czech Republic will have to take to implement the acquis requirements. Finally it makes an assessment as to how successful implementation of the acquis will prove beneficial to the acceding states and the parties which rely on the service that the regulatory authorities provide (i.e. the public, farmers and growers and the agrochemical industry).

Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes

PubMed Central

Tohn, R; Blumenfeld, H; Haeryfar, S M M; Veerapen, N; Besra, G S; Porcelli, S A; Delovitch, T L

2011-01-01

We have reported previously that treatment of non-obese diabetic (NOD) mice with the invariant natural killer T (iNK T) cell agonist α-galactosylceramide C26:0 (α-GalCer) or its T helper type 2 (Th2)-biasing derivative α-GalCer C20:2 (C20:2) protects against type 1 diabetes (T1D), with C20:2 yielding greater protection. After an initial response to α-GalCer, iNK T cells become anergic upon restimulation. While such anergic iNK T cells can induce tolerogenic dendritic cells (DCs) that mediate protection from T1D, chronic administration of α-GalCer also results in long-lasting anergy accompanied by significantly reduced iNK T cell frequencies, which raises concerns about its long-term therapeutic use. In this study, our objective was to understand more clearly the roles of anergy and induction of tolerogenic DCs in iNK T cell-mediated protection from T1D and to circumvent potential complications associated with α-GalCer. We demonstrate that NOD iNK T cells activated during multi-dose (MD) treatment in vivo with C20:2 enter into and exit from anergy more rapidly than after activation by α-GalCer. Importantly, this shorter duration of iNK T cells in the anergic state promotes the more rapid induction of tolerogenic DCs and reduced iNK T cell death, and enables C20:2 stimulated iNK T cells to elicit enhanced protection from T1D. Our findings further that suggest C20:2 is a more effective therapeutic drug than α-GalCer for protection from T1D. Moreover, the characteristics of C20:2 provide a basis of selection of next-generation iNK T cell agonists for the prevention of T1D. PMID:21361909

Medicare and Medicaid fraud and abuse regulations.

PubMed

Liang, F Z; Black, B L

1991-11-01

Specific business arrangements that are protected under legislation and regulations governing parties doing business with Medicare or Medicaid are discussed. Regulations implementing the Medicare and Medicaid Patient Protection Act of 1987 specify practices and activities that are not subject to criminal penalties under the antikickback provisions of the Social Security Act or to exclusion from Medicare or state health-care programs. As of July 29, 1991, all organized health-care settings that receive payments from either Medicare or state health-care programs must comply with these regulations. The final rule sets forth "safe harbors"--exceptions to prohibitions against (1) kickbacks, bribes, rebates, and other illegal activities involving remunerations for patient referrals and (2) inducements to purchase or lease goods paid for by Medicare or state health-care programs. The safe harbors comprise 11 broad categories--investment interests, space rental, equipment rental, personal services and management contracts, purchase of a medical practice, referral services, warranties, discounts, employees, group purchasing organizations, and waiver of deductibles and coinsurance. Implications for pharmacy are discussed. These regulations will affect the purchase of pharmaceuticals by institutional pharmacies. Each institution should review its current practices to determine whether they are within the safe harbors.

Development of a new categorization system for pesticides exposure to support harmonized reporting between EU Member States.

PubMed

Settimi, Laura; Orford, Rob; Davanzo, Franca; Hague, Charlotte; Desel, Herbert; Pelclova, Daniela; Dragelyte, Gabija; Mathieu-Nolf, Monique; Adams, Richard; Duarte-Davidson, Raquel

2016-05-01

European legislation requires reporting from Member States on acute poisoning incidents involving pesticides. However, standard rules for data collection and reporting have not yet been set out. The new categorization system presented in this paper is aimed at enabling Member States to gather comparable data and provide standard reporting on pesticide poisoning exposures. European Regulations providing separate official categorization of biocidal and plant protection pesticides, were used as a basis to build up a unified pesticide categorization and coding system. Data on selected pesticide exposures collected by Poison Control Centres in six EU countries were reviewed, categorized and reported according to the proposed system. The resulting pesticide categorization system has two dimensions. The first part identifies the main category of use, i.e. biocide/plant protection pesticide/unknown, and the secondary category of use, e.g. Rodenticides, Insecticides and acaricides. The second part of the system is organized into two levels: level one identifies chemical grouping, e.g. Coumarins, Pyrethrins/pyrethroids, while level two identifies the active compound by using its Chemical Abstract Service Registry Number. The system was used to provide a unified categorization to compare exposures to plant protection and biocidal Rodenticides and Pyrethrins/pyrethroids Insecticides and acaricides identified by six EU member states. The developed pesticide categorization system was successfully applied to data extracted from different databases and was able to make the required information comparable. The data reported filling in common templates containing a pre-ordinate list of active compounds categorized according the proposed system, highlighted different capabilities in data collection and recording, showing that some of the collaborating centres were not able to distinguish between main categories of pesticide products or provide information on active compounds. The results indicate that a special effort should be dedicated to support detailed data recording at national level. Providing common tools to systematically report to the EU Commission hazardous exposures to pesticides, as well as to other selected categories of products, could allow for data comparability between Member States and greatly improve post marketing surveillance and alerting systems in Europe. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cobalt Chloride Upregulates Impaired HIF-1α Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats.

PubMed

Wu, Jianjiang; Yang, Long; Xie, Peng; Yu, Jin; Yu, Tian; Wang, Haiying; Maimaitili, Yiliyaer; Wang, Jiang; Ma, Haiping; Yang, Yining; Zheng, Hong

2017-01-01

Previous studies from our group have demonstrated that sevoflurane post-conditioning (SPC) protects against myocardial ischemia reperfusion injury via elevating the intranuclear expression of hypoxia inducible factor-1 alpha (HIF-1α). However, diabetic SPC is associated with decreased myocardial protection and disruption of the HIF-1 signaling pathway. Previous studies have demonstrated that cobalt chloride (CoCl 2 ) can upregulate HIF-1α expression under diabetic conditions, but whether myocardial protection by SPC can be restored afterward remains unclear. We established a rat model of type 2 diabetes and a Langendorff isolated heart model of ischemia-reperfusion injury. Prior to reperfusion, 2.4% sevoflurane was used as a post-conditioning treatment. The diabetic rats were treated with CoCl 2 24 h before the experiment. At the end of reperfusion, tests were performed to assess myocardial function, infarct size, mitochondrial morphology, nitric oxide (NO), Mitochondrial reactive oxygen species (ROS), mitochondrial respiratory function and enzyme activity, HIF-1α, vascular endothelial growth factor (VEGF) and endothelial NO synthase (eNOS) protein levels. In addition, myocardial protection by SPC was monitored after the blood glucose levels were lowered by insulin. The diabetic state was associated with deficient SPC protection and decreased HIF-1α expression. After treating the diabetic rats with CoCl 2 , SPC significantly upregulated the expression of HIF-1α, VEGF and eNOS, which markedly improved cardiac function, NO, mitochondrial respiratory function, and enzyme activity and decreased the infarction areas and ROS. In addition, these effects were not influenced by blood glucose levels. This study proved that CoCl 2 activates the HIF-1α signaling pathway, which restores SPC-dependent myocardial protection under diabetic conditions, and the protective effects of SPC were independent of blood glucose levels.

Report on the BWR owners group radiation protection/ALARA Committee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aldrich, L.R.

1995-03-01

Radiation protection programs at U.S. boiling water reactor (BWR) stations have evolved during the 1980s and early 1990s from a regulatory adherence-based endeavor to a proactive, risk-based radiation protection and prevention mission. The objectives are no longer to merely monitor and document exposure to radiation and radioactive materials. The focus of the current programs is the optimization of radiation protection of occupational workers consistent with the purpose of producing cost-effective electric power. The newly revised 10 CFR 20 defines the term ALARA (as low as reasonably achievable) to take into account the state of technology, the economics of improvements inmore » relation to the state of the technology, and the benefits to the public health and safety. The BWR Owners Group (BWROG) initially formed the Radiation Protection/ALARA Committee in January 1990 to evaluate methods of reducing occupational radiation exposure during refueling outages. Currently, twenty U.S. BWR owner/operators (representing 36 of the operational 37 domestic BWR units), as well as three foreign BWR operators (associate members), have broadened the scope to promote information exchange between BWR radiation protection professionals and develop good practices which will affect optimization of their radiation protection programs. In search of excellence and the challenge of becoming {open_quotes}World Class{close_quotes} performers in radiation protection, the BWROG Radiation Protection/ALARA Committee has recently accepted a role in assisting the member utilities in improving radiation protection performance in a cost-effective manner. This paper will summarize the recent activities of this Committee undertaken to execute their role of exchanging information in pursuit of optimizing the improvement of their collective radiation protection performance.« less

Protection of surface states in topological nanoparticles

NASA Astrophysics Data System (ADS)

Siroki, Gleb; Haynes, Peter D.; Lee, Derek K. K.; Giannini, Vincenzo

2017-07-01

Topological insulators host protected electronic states at their surface. These states show little sensitivity to disorder. For miniaturization one wants to exploit their robustness at the smallest sizes possible. This is also beneficial for optical applications and catalysis, which favor large surface-to-volume ratios. However, it is not known whether discrete states in particles share the protection of their continuous counterparts in large crystals. Here we study the protection of the states hosted by topological insulator nanoparticles. Using both analytical and tight-binding simulations, we show that the states benefit from the same level of protection as those on a planar surface. The results hold for many shapes and sustain surface roughness which may be useful in photonics, spectroscopy, and chemistry. They complement past studies of large crystals—at the other end of possible length scales. The protection of the nanoparticles suggests that samples of all intermediate sizes also possess protected states.

In re J.J.

PubMed

1990-05-07

The Ohio Court of Appeals, Butler County, held that the state may compel a 14-year-old to undergo medical treatment for gonorrhea, even though such treatment would violate his religious beliefs. The juvenile's belief in faith healing prohibited him from accepting medical help. Based on this refusal, the court found the juvenile to be a "dependent child," noting that his condition and environment warranted that the state assume his guardianship. Although minors have constitutional rights, including the right to freedom of religion, states have broader authority to regulate the activities of children than of adults. The state has an interest in the protection of society, and the juvenile's sexual activity created a risk to himself and to the community. The juvenile's mother was responsible for his medical expenses, despite her assertion that she was not at fault and that the state had not considered her ability to pay.

Economic impacts of anthropogenic activities on coastlines of the United States

USGS Publications Warehouse

Magoon, Orville T.; Williams, S. Jeffress; Lent, Linda K.; Richmond, James A.; Treadwell, Donald D.; Douglass, Scott L.; Edge, Billy L.; Ewing, Lesley C.; Pratt, Anthony P.

2004-01-01

Anthropogenic activities primarily impact coasts by reducing sediment inputs, altering sediment transport processes, and accelerating sediment losses to the offshore. These activities include: sand and gravel extraction, navigation and shore protection works; non-structural shoreline management strategies such as beach nourishment, sand by-passing and beach scraping, dams and flood control works; channel and inlet dredging; subsidence caused by fluid extraction and reduction of carbonate beach material. Although many of these activities have improved the quality of life, they also have had unintended effects on the coast. The issues that arise from human alterations of the coast are common to many coastal regions around the world; this paper draws from several areas of the United States to present an overview and provisional assessment of the economic consequences of anthropogenic activities along the Pacific coast.

ACTIVE AND SEMI-PASSIVE LIME TREATMENT OF ACID MINE DRAINAGE AT LEVIATHAN MINE, CALIFORNIA CAPSULE

EPA Science Inventory

As part of the Superfund Innovative Technology Evaluation (SITE) program, U.S. Environmental Protection Agency (EPA), National Risk Management Research Laboratory (NRMRL), in cooperation with EPA Region IX, the state of California, and the Atlantic Richfield Company (ARCO) evalua...

ACTIVE AND SEMI-PASSIVE LIME TREATMENT OF ACID MINE DRAINAGE AT LEVIATHAN MINE, CALIFORNIA BULLETIN

EPA Science Inventory

As part of the Superfund Innovative Technology Evaluation (SITE) program, U.S. Environmental Protection Agency (EPA) National Risk Management Research Laboratory (NRMRL), in cooperation with EPA Region IX, the state of California, and the Atlantic Richfield Company (ARCO) evaluat...

ACTIVE AND SEMI-PASSIVE LIME TREATMENT OF ACID MINE DRAINAGE AT LEVIATHAN MINE, CALIFORNIA ITER

EPA Science Inventory

As part of the Superfund Innovative Tecbnology Evaluation (SITE) program, U.S. Environmental Protection Agency (EPA), National Risk Management Research Laboratory (NRMRL), in cooperation with EPA Region IX, the state of California, and the Atlantic Richfield Company (ARCO) evalua...

75 FR 39586 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-09

... States who have signed Agreements with NRC under Section 274b. of the Atomic Energy Act (Act)) plus one... protect public health and safety. A copy of the final supporting statement may be viewed free of charge at...

Lake States Aspen Productivity Following Soil Compaction and Organic Matter Removal

Treesearch

Douglas M. Stone

2002-01-01

Aspen (Populus tremuloides Michx. and P. grandidentata Michx.) provides wood products, watershed protection, and wildlife habitat for numerous game and non-game species across the northern Great Lakes region. Sustaining the productivity of these ecosystems requires maintaining soil productivity. Management activities that decrease...

75 FR 35507 - Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-22

....regulations.gov , a Federal E-Government Web site that allows the public to find, review, and submit comments...-395-3952; e-mail [email protected] . FOR FURTHER INFORMATION CONTACT: Marguerite Pridgen at the.... Respondents: Contractors, States, Local Governments, Universities, Non-Profit Organizations, For-Profit...

42 CFR 84.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... state and supplied to the wearer in gaseous form. (g) dBA means sound pressure levels in decibels, as... RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES General Provisions § 84.2 Definitions. As..., as evidence of such approval. (c) Approved means conforming to the minimum requirements of this part...

High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project

EPA Science Inventory

The United States Environmental Protection Agency (U.S. EPA) must characterize potential risks to human health and the environment associated with manufacture and use of thousands of chemicals. High-throughput screening (HTS) for biological activity allows the ToxCast research pr...

77 FR 25486 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... Program Performance Report. OMB No.: 0980-0160. Description: This information collection is required by... Report for the preceding fiscal year of activities and accomplishments and of conditions in the State. The information in the Annual Report will be aggregated into a national profile of Protection and...

76 FR 22713 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

... Program Performance Report. OMB No.: 0980-0160. Description: This information collection is required by... Report for the preceding fiscal year of activities and accomplishments and of conditions in the State. The information in the Annual Report will be aggregated into a national profile of Protection and...

29 CFR 42.8 - Coordination plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... coordination plan shall describe the present program responsibilities of OSHA for protecting the safety and... under, and alleged violations of, OSHA recorded in the logs of the OSHA State and area offices, and shall provide general goals for OSHA enforcement activities for the following year as established by...

76 FR 38151 - Agency Information Collection Activities; Proposed Collection; Comment Request; Reporting and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... Nonroad Engines and Recreational Vehicles AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... this action are importers into the United States of nonroad engines and vehicles. Title: Reporting and Recordkeeping Requirements for Importation of Nonroad Engines and Recreational Vehicles (Renewal). ICR numbers...

Methods for Measuring Occurrence and Exposure From Viruses in Drinking and Recreational Water

EPA Science Inventory

The United States Environmental Protection Agency (EPA) has an active research program to develop and improve methods for detecting human enteric viruses in recreational, source, and drinking waters. EPA is also developing methods to measure exposure to waterborne viruses and ap...

40 CFR 300.605 - State trustees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 28 2011-07-01 2011-07-01 false State trustees. 300.605 Section 300.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... access to appropriate state officials with environmental protection, emergency response, and natural...

40 CFR 300.605 - State trustees.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 29 2013-07-01 2013-07-01 false State trustees. 300.605 Section 300.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... access to appropriate state officials with environmental protection, emergency response, and natural...

40 CFR 300.605 - State trustees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false State trustees. 300.605 Section 300.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... access to appropriate state officials with environmental protection, emergency response, and natural...

40 CFR 300.605 - State trustees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 29 2012-07-01 2012-07-01 false State trustees. 300.605 Section 300.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... access to appropriate state officials with environmental protection, emergency response, and natural...

40 CFR 300.605 - State trustees.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 28 2014-07-01 2014-07-01 false State trustees. 300.605 Section 300.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... access to appropriate state officials with environmental protection, emergency response, and natural...

Defence force activities in marine protected areas: environmental management of Shoalwater Bay Training Area, Queensland, Australia

NASA Astrophysics Data System (ADS)

Wu, Wen; Wang, Xiaohua; Paull, David; Kesby, Julie

2010-05-01

Environmental management of military activities is of growing global concern by defence forces. As one of the largest landholders in Australia, the Australian Defence Force (ADF) is increasingly concerned with sustainable environmental management. This paper focuses on how the ADF is maintaining effective environmental management, especially in environmentally sensitive marine protected areas. It uses Shoalwater Bay Training Area (SWBTA) as a research example to examine environmental management strategies conducted by the ADF. SWBTA is one of the most significant Defence training areas in Australia, with a large number of single, joint and combined military exercises conducted in the area. With its maritime component contained in the Great Barrier Reef Marine Park (GBRMP), the Great Barrier Reef World Heritage Area (GBRWHA), and abutting Queensland’s State Marine Parks, it has high protection values. It is therefore vital for the ADF to adopt environmentally responsible management while they are conducting military activities. As to various tools employed to manage environmental performance, the ISO 14001 Environmental Management System (EMS) is widely used by the ADF. This paper examines military activities and marine environmental management within SWBTA, using the Talisman Saber (TS) exercise series as an example. These are extensive joint exercises conducted by the ADF and the United States defence forces. The paper outlines relevant legislative framework and environmental policies, analyses how the EMS operates in environmental management of military activities, and how military activities comply with these regulations. It discusses the implementation of the ADF EMS, including risk reduction measures, environmental awareness training, consultation and communication with stakeholders. A number of environmental management actions used in the TS exercises are presented to demonstrate the EMS application. Our investigations to this point indicate that the ADF is complying with all relevant legislation and policies. Further research is required to confirm compliance and conclude that military activities have good accord with environmental management objectives.

An interdisciplinary framework to evaluate bioshield plantations: Insights from peninsular India

NASA Astrophysics Data System (ADS)

Mukherjee, Nibedita; Dahdouh-Guebas, Farid; Koedam, Nico; Shanker, Kartik

2015-02-01

Bioshields or coastal vegetation structures are currently amongst the most important coastal habitat modification activities in south-east Asia, particularly after the December 2004 tsunami. Coastal plantations have been promoted at a large scale as protection against severe natural disasters despite considerable debate over their efficacy as protection measures. In this paper, we provide an interdisciplinary framework for evaluating and monitoring coastal plantations. We then use this framework in a case study in peninsular India. We conducted a socio-ecological questionnaire-based survey on government and non-government organizations directly involved in coastal plantation efforts in three 2004 Indian Ocean tsunami affected states in mainland India. We found that though coastal protection was stated to be the primary cause, socio-economic factors like providing rural employment were strong drivers of plantation activities. Local communities were engaged primarily as daily wage labour for plantation rather than in the planning or monitoring phases. Application of ecological criteria has been undermined during the establishment and maintenance of plantations and there was a general lack of awareness about conservation laws relating to coastal forests. While ample flow of international aid has fuelled the plantation of exotics in the study area particularly after the Indian Ocean tsunami in 2004, the long term ecological consequences need further evaluation and rigorous monitoring in the future.

Micro-Fabricated Solid-State Radiation Detectors for Active Personal Dosimetry

NASA Technical Reports Server (NTRS)

Wrbanek, John D.; Wrbanek, Susan Y.; Fralick, Gustave C.; Chen, Liang-Yu

2007-01-01

Active radiation dosimetry is important to human health and equipment functionality for space applications outside the protective environment of a space station or vehicle. This is especially true for long duration missions to the moon, where the lack of a magnetic field offers no protection from space radiation to those on extravehicular activities. In order to improve functionality, durability and reliability of radiation dosimeters for future NASA lunar missions, single crystal silicon carbide devices and scintillating fiber detectors are currently being investigated for applications in advanced extravehicular systems. For many years, NASA Glenn Research Center has led significant efforts in silicon carbide semiconductor technology research and instrumentation research for sensor applications under extreme conditions. This report summarizes the technical progress and accomplishments toward characterization of radiation-sensing components for the recommendation of their fitness for advanced dosimetry development.

40 CFR 763.123 - May a State implement its own asbestos worker protection plan?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false May a State implement its own asbestos... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos Worker Protection § 763.123 May a State implement its own asbestos worker protection plan? This section describes the process under which a State may be...

40 CFR 763.123 - May a State implement its own asbestos worker protection plan?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false May a State implement its own asbestos... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos Worker Protection § 763.123 May a State implement its own asbestos worker protection plan? This section describes the process under which a State may be...

40 CFR 763.123 - May a State implement its own asbestos worker protection plan?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false May a State implement its own asbestos... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos Worker Protection § 763.123 May a State implement its own asbestos worker protection plan? This section describes the process under which a State may be...

40 CFR 763.123 - May a State implement its own asbestos worker protection plan?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false May a State implement its own asbestos... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos Worker Protection § 763.123 May a State implement its own asbestos worker protection plan? This section describes the process under which a State may be...

40 CFR 763.123 - May a State implement its own asbestos worker protection plan?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false May a State implement its own asbestos... (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos Worker Protection § 763.123 May a State implement its own asbestos worker protection plan? This section describes the process under which a State may be...

The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection

PubMed Central

Colín-González, Ana L.; Santana, Ricardo A.; Silva-Islas, Carlos A.; Chánez-Cárdenas, Maria E.; Santamaría, Abel; Maldonado, Perla D.

2012-01-01

Aged garlic extract (AGE) is an odorless garlic preparation containing S-allylcysteine (SAC) as its most abundant compound. A large number of studies have demonstrated the antioxidant activity of AGE and SAC in both in vivo—in diverse experimental animal models associated to oxidative stress—and in vitro conditions—using several methods to scavenge reactive oxygen species or to induce oxidative damage. Derived from these experiments, the protective effects of AGE and SAC have been associated with the prevention or amelioration of oxidative stress. In this work, we reviewed different antioxidant mechanisms (scavenging of free radicals and prooxidant species, induction of antioxidant enzymes, activation of Nrf2 factor, inhibition of prooxidant enzymes, and chelating effects) involved in the protective actions of AGE and SAC, thereby emphasizing their potential use as therapeutic agents. In addition, we highlight the ability of SAC to activate Nrf2 factor—a master regulator of the cellular redox state. Here, we include original data showing the ability of SAC to activate Nrf2 factor in cerebral cortex. Therefore, we conclude that the therapeutic properties of these molecules comprise cellular and molecular mechanisms at different levels. PMID:22685624

Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation

PubMed Central

2013-01-01

Background Astrocytes respond to local insults within the brain and the spinal cord with important changes in their phenotype. This process, overall known as “activation”, is observed upon proinflammatory stimulation and leads astrocytes to acquire either a detrimental phenotype, thereby contributing to the neurodegenerative process, or a protective phenotype, thus supporting neuronal survival. Within the mechanisms responsible for inflammatory neurodegeneration, oxidative stress plays a major role and has recently been recognized to be heavily influenced by changes in cytosolic iron levels. In this work, we investigated how activation affects the competence of astrocytes to handle iron overload and the ensuing oxidative stress. Methods Cultures of pure cortical astrocytes were preincubated with proinflammatory cytokines (interleukin-1β and tumor necrosis factor α) or conditioned medium from lipopolysaccharide-activated microglia to promote activation and then exposed to a protocol of iron overload. Results We demonstrate that activated astrocytes display an efficient protection against iron-mediated oxidative stress and cell death. Based on this evidence, we performed a comprehensive biochemical and molecular analysis, including a transcriptomic approach, to identify the molecular basis of this resistance. Conclusions We propose the protective phenotype acquired after activation not to involve the most common astrocytic antioxidant pathway, based on the Nrf2 transcription factor, but to result from a complex change in the expression and activity of several genes involved in the control of cellular redox state. PMID:24160637

Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization.

PubMed

Neuspiel, Margaret; Zunino, Rodolfo; Gangaraju, Sandhya; Rippstein, Peter; McBride, Heidi

2005-07-01

Mitochondrial fusion in higher eukaryotes requires at least two essential GTPases, Mitofusin 1 and Mitofusin 2 (Mfn2). We have created an activated mutant of Mfn2, which shows increased rates of nucleotide exchange and decreased rates of hydrolysis relative to wild type Mfn2. Mitochondrial fusion is stimulated dramatically within heterokaryons expressing this mutant, demonstrating that hydrolysis is not requisite for the fusion event, and supporting a role for Mfn2 as a signaling GTPase. Although steady-state mitochondrial fusion required the conserved intermembrane space tryptophan residue, this requirement was overcome within the context of the hydrolysis-deficient mutant. Furthermore, the punctate localization of Mfn2 is lost in the dominant active mutants, indicating that these sites are functionally controlled by changes in the nucleotide state of Mfn2. Upon staurosporine-stimulated cell death, activated Bax is recruited to the Mfn2-containing puncta; however, Bax activation and cytochrome c release are inhibited in the presence of the dominant active mutants of Mfn2. The dominant active form of Mfn2 also protected the mitochondria against free radical-induced permeability transition. In contrast to staurosporine-induced outer membrane permeability transition, pore opening induced through the introduction of free radicals was dependent upon the conserved intermembrane space residue. This is the first evidence that Mfn2 is a signaling GTPase regulating mitochondrial fusion and that the nucleotide-dependent activation of Mfn2 concomitantly protects the organelle from permeability transition. The data provide new insights into the critical relationship between mitochondrial membrane dynamics and programmed cell death.

22 CFR 102.19 - Protection of United States property.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Protection of United States property. 102.19... States Aircraft Accidents Abroad Foreign Aircraft Accidents Involving United States Persons Or Property § 102.19 Protection of United States property. The local Foreign Service office shall follow...

22 CFR 102.19 - Protection of United States property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Protection of United States property. 102.19... States Aircraft Accidents Abroad Foreign Aircraft Accidents Involving United States Persons Or Property § 102.19 Protection of United States property. The local Foreign Service office shall follow...

22 CFR 102.19 - Protection of United States property.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Protection of United States property. 102.19... States Aircraft Accidents Abroad Foreign Aircraft Accidents Involving United States Persons Or Property § 102.19 Protection of United States property. The local Foreign Service office shall follow...

Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress.

PubMed

Rodríguez-Ramiro, Ildefonso; Ramos, Sonia; Bravo, Laura; Goya, Luis; Martín, Maria Ángeles

2012-10-01

Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect against oxidative stress- and chemical-induced injury in colonic cells by modulating the endogenous cellular defence. However, the precise mechanism for this protection is not fully understood. Herein, we examined the effect of PB2 on the expression of one of the major antioxidant/detoxificant enzymes related to intestinal protection, the glutathione S-transferase P1 (GSTP1), and the molecular mechanisms involved. Human colonic Caco-2 cells were treated with PB2 at different times and enzymatic activity, and mRNA and protein levels of GSTP1 were evaluated. The nuclear translocation of the transcription factor NF-erythroid 2-related factor (Nrf2) and the phosphorylation states of specific proteins central to intracellular signalling cascades were also investigated. PB2 induced the expression and activity of GSTP1 and the nuclear translocation of Nrf2. Interestingly, two important signalling proteins involved in Nrf2 translocation, the extracellular signal-regulated protein kinases (ERKs) and the p38 mitogen-activated protein kinase (MAPK) were also activated. Further experiments with specific inhibitors of both pathways confirmed their critical role in the beneficial effects induced by PB2. The present results show that PB2 protects against oxidative injury in colonic cells and up-regulate the expression of GSTP1 via a mechanism that involves ERK and p38 MAPK activation and Nrf2 translocation. These results provide a molecular basis for the potential contribution of PB2 in the prevention of oxidative stress-related intestinal injury and gut pathologies.

LAND USE CHANGE DUE TO URBANIZATION FOR THE MID-ATLANTIC INTEGRATED ASSESSMENT REGION OF THE EASTERN UNITED STATES

EPA Science Inventory

The U.S. Environmental Protection Agency's (EPA) Regional Vulnerability Assessment Pro- gram (REVA) is designed to develop and demonstrate approaches to identify the ecosystems at the greatest risk from regional population growth and economic activity (Smith, 1999). A region is a...

5 CFR 733.105 - Permitted political activities-employees who reside in designated localities and are employed in...

Code of Federal Regulations, 2010 CFR

2010-01-01

... Investigation; (3) United States Secret Service; (4) Central Intelligence Agency; (5) National Security Council; (6) National Security Agency; (7) Defense Intelligence Agency; (8) Merit Systems Protection Board; (9... Section 733.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE...

40 CFR 130.11 - Program management.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Program management. 130.11 Section 130... PLANNING AND MANAGEMENT § 130.11 Program management. (a) State agencies may apply for grants under sections 106, 205(j) and 205(g) to carry out water quality planning and management activities. Interstate...

40 CFR 130.11 - Program management.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Program management. 130.11 Section 130... PLANNING AND MANAGEMENT § 130.11 Program management. (a) State agencies may apply for grants under sections 106, 205(j) and 205(g) to carry out water quality planning and management activities. Interstate...

40 CFR 130.11 - Program management.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Program management. 130.11 Section 130... PLANNING AND MANAGEMENT § 130.11 Program management. (a) State agencies may apply for grants under sections 106, 205(j) and 205(g) to carry out water quality planning and management activities. Interstate...

77 FR 14393 - Family Violence Prevention and Services/Grants to State Domestic Violence Coalitions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... relatives, involvement in after-school activities) and characteristics (e.g., self-esteem, relationship skills) can moderate the impacts of past and future negative experiences. These protective factors are... interventions are in place to build skills and capacities that contribute to the healthy, positive, and...

Office of Environmental Education. 1991 Progress Report.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC. Office of Environmental Education.

As improvements in environmental protection become more dependent upon the activities of individual citizens, so grows the need for an environmentally literate citizenry. The stated goal of the Office of Environmental Education is to instill in students a sense of concern for, a mutual dependence upon, and an intimacy toward the natural…

77 FR 36031 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... monthly Social Security benefits to qualified World War II veterans residing outside the United States. An... Reduction Act of 1995, effective October 1, 1995. This notice includes revisions of OMB-approved information..., 2012. Individuals can obtain copies of the OMB clearance packages by writing to [email protected] . 1...

On Campus Study of Florida Wildlife: Project Report.

ERIC Educational Resources Information Center

Newcomb-Jones, Carol

Ecosystem management is an integrated approach to managing Florida's biological and physical environments designed to maintain, protect, and improve the state's natural, managed, and human communities. This document contains activities designed for 4th-5th grade students that meet the guidelines of Florida's K-12 Science Framework to better…

Exploring the Relationship of Outdoor Recreational Resources to Physical Inactivity, Obesity and Diabetes for the Continental United States

EPA Science Inventory

Background: Access to outdoor recreational resources is important for promoting healthy behavior and physical activity, which may decrease the risk of disease. To date, no study has examined the relationship between access to outdoor recreational resources (including protected l...

Campus Religious Conflict Should Go Public

ERIC Educational Resources Information Center

Jakobsen, Janet R.

2006-01-01

This article describes the difficult times for faculty members and others who are committed to academic freedom. Among a number of examples, the author presents the bills introduced by state legislatures across the country that aim to restrict faculty activity in the name of protecting student freedom. Such legislative initiatives use the language…

40 CFR 130.11 - Program management.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Program management. 130.11 Section 130... PLANNING AND MANAGEMENT § 130.11 Program management. (a) State agencies may apply for grants under sections 106, 205(j) and 205(g) to carry out water quality planning and management activities. Interstate...

78 FR 27972 - Agency Information Collection Activities; Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-13

... Administration (HRSA)--Funded Traumatic Brain Injury Grants (OMB No. 0915-xxxx)--New Abstract: This survey is designed to collect information from HRSA- funded Traumatic Brain Injury (TBI) State Implementation Partnership Grants and Protection and Advocacy for Traumatic Brain Injury (TBI) Grants regarding the impact of...

Nitrogen Saturation in Temperate Forest Ecosystems

Treesearch

John Aber; William McDowell; Knute Nadelhoffer; Alison Magill; Glenn Berntson; Mark Kamakea; Steven McNulty; William Currie; Lindsey Rustad; Ivan Fernandez

1998-01-01

Nitrogen emissions to the atmosphere due to human activity remain elevated in industrialized regions of the world and are accelerating in many developing regions (Galloway 1995). Although the deposition of sulfur has been reduced over much of the United States and Europe by aggressive environmental protection policies, current nitrogen deposition reduction targets in...

76 FR 53123 - Agency Information Collection Activities; Proposed Collection; Comment Request on Two Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... at least 25 percent (measured on an average monthly basis) of the water withdrawn for cooling... subject line) Mail: Water Docket, Environmental Protection Agency, Mailcode: 4101T, 1200 Pennsylvania Ave... . FOR FURTHER INFORMATION CONTACT: Amelia Letnes, State and Regional Branch, Water Permits Division, OWM...

Altered states: state health privacy laws and the impact of the Federal Health Privacy Rule.

PubMed

Pritts, Joy L

2002-01-01

Although the Federal Health Privacy Rule has evened out some of the inconsistencies between states' health privacy laws, gaps in protection still remain. Furthermore, the Federal Rule contains some lax standards for the disclosure of health information. State laws can play a vital role in filling these gaps and strengthening the protections afforded health information. By enacting legislation that has higher privacy-protective standards than the Federal Health Privacy Rule, states can play three important roles. First, because they can directly regulate entities that are beyond HHS's mandate, states can afford their citizens a broader degree of privacy protection than the Federal Health Privacy Rule. Second, by having state health privacy laws, states can enforce privacy protections at the local level. Finally, action by the states can positively influence health privacy policies at the federal level by raising the standard as to what constitutes sufficient privacy protection. High privacy protections imposed by states may serve as the standard for comprehensive federal legislation, if and when Congress reconsiders the issue. So far, states' reactions to the Federal Privacy Rule have been mixed. Only time will tell whether states will assume the mantle of leadership on health privacy or relinquish their role as the primary protectors of health information.

Evaluation of the relevance of the glassy state as stability criterion for freeze-dried bacteria by application of the Arrhenius and WLF model.

PubMed

Aschenbrenner, Mathias; Kulozik, Ulrich; Foerst, Petra

2012-12-01

The aim of this work was to describe the temperature dependence of microbial inactivation for several storage conditions and protective systems (lactose, trehalose and dextran) in relation to the physical state of the sample, i.e. the glassy or non-glassy state. The resulting inactivation rates k were described by applying two models, Arrhenius and Williams-Landel-Ferry (WLF), in order to evaluate the relevance of diffusional limitation as a protective mechanism. The application of the Arrhenius model revealed a significant decrease in activation energy E(a) for storage conditions close to T(g). This finding is an indication that the protective effect of a surrounding glassy matrix can, at least, partly be ascribed to its inherent restricted diffusion and mobility. The application of the WLF model revealed that the temperature dependence of microbial inactivation above T(g) is significantly weaker than predicted by the universal coefficients. Thus, it can be concluded that microbial inactivation is not directly linked with the mechanical relaxation behavior of the surrounding matrix as it was reported for viscosity and crystallization phenomena in case of disaccharide systems. Copyright © 2012. Published by Elsevier Inc.

Food allergen law and the Food Allergen Labeling and Consumer Protection Act of 2004: falling short of true protection for food allergy sufferers.

PubMed

Roses, Jonathan B

2011-01-01

In 2004, Congress mandated labeling of food allergens on packaged foods for the first time by passing the Food Allergen Labeling and Consumer Protection Act (FALCPA). FALCPA requires that manufacturers of foods containing one of the eight major allergens responsible for 90 percent of food allergies either state on the food's packaging that the food contains the allergen, or refers to the allergen by a name easily understandable by consumers in the ingredients listing. Despite this important first step in protecting consumers with food allergies, FALCPA left unregulated the use of conditional precautionary statements (e.g., "may contain [allergen]"), which many manufacturers have used as a low-cost shield to liability. Further, FALCPA applies only to packaged foods, and does not mandate listing of food allergen ingredients in restaurants. This article discusses the history of food allergen litigation in the United States, highlighting the problems plaintiffs have faced in seeking recovery for allergic reactions to a defendants' food product, and some of the practical difficulties still extant due to the lack of regulation of precautionary statements. Also presented is a review of the Massachusetts Food Allergy Awareness Act, the first state legislation requiring restaurants to take an active role in educating employees and consumers about the presence and dangers of food allergens.

Differences Between Dual-Method and Non–Dual-Method Protection Use in a Sample of Young African American Women Residing in the Southeastern United States

PubMed Central

Sales, Jessica M.; Latham, Teaniese P.; DiClemente, Ralph J.; Rose, Eve

2013-01-01

Objectives To characterize dual-method protection users and report the prevalence of dual-method use among young adult African American women residing in the Southeastern United States. Design Analysis of baseline data from a randomized controlled trial. Setting A clinic-based sample of young women enrolled in a randomized trial of a human immunodeficiency virus (HIV)–prevention program in Atlanta, Georgia, from June 2005 to June 2007. Participants African American women aged 14 to 20 years who reported unprotected sexual activity in the past 6months. Of the eligible adolescents, 94% (N=701) were enrolled in the study and completed baseline assessments. Outcome Measures Dual-method protection use as well as sociodemographic, individual-level, interpersonal-level, and community-level factors and interpersonal communication skills. Only data from the baseline assessment, before randomization, were used for the analysis. Results A total of 102 participants (14.6%) were classified as dual-method protection users. After controlling for age and clinic, significant differences between dual-method users and non–dual-method users were found for impulsivity, self-esteem, social support, relationship style, partner communication self-efficacy, and fear of condom negotiation. Conclusions Dual-method protection use is low. Identification of factors that differentiate dual-method users from non–dual-method users at the individual, interpersonal, and community levels in this young African American sample suggests that HIV, sexually transmitted disease, and unintended pregnancy risk–reduction programs should address factors at each level, not simply the individual level, and that this may involve structural and/or clinical counseling practice changes in clinics that serve young women, to optimally facilitate dual-method protection use among young African American women in the Southeastern United States. PMID:21135341

Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage.

PubMed

von Montfort, Claudia; Alili, Lirija; Teuber-Hanselmann, Sarah; Brenneisen, Peter

2015-01-01

Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already been observed. However, the effect on important parameters such as cell death, proliferation and redox state of the cells needs further clarification. Here, we present that nanoceria prevent HDF from reactive oxygen species (ROS)-induced cell death and stimulate proliferation due to the antioxidative property of these particles. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Protection Enhances Community and Habitat Stability: Evidence from a Mediterranean Marine Protected Area

PubMed Central

Fraschetti, Simonetta; Guarnieri, Giuseppe; Bevilacqua, Stanislao; Terlizzi, Antonio; Boero, Ferdinando

2013-01-01

Rare evidences support that Marine Protected Areas (MPAs) enhance the stability of marine habitats and assemblages. Based on nine years of observation (2001–2009) inside and outside a well managed MPA, we assessed the potential of conservation and management actions to modify patterns of spatial and/or temporal variability of Posidonia oceanica meadows, the lower midlittoral and the shallow infralittoral rock assemblages. Significant differences in both temporal variations and spatial patterns were observed between protected and unprotected locations. A lower temporal variability in the protected vs. unprotected assemblages was found in the shallow infralittoral, demonstrating that, at least at local scale, protection can enhance community stability. Macrobenthos with long-lived and relatively slow-growing invertebrates and structurally complex algal forms were homogeneously distributed in space and went through little fluctuations in time. In contrast, a mosaic of disturbed patches featured unprotected locations, with small-scale shifts from macroalgal stands to barrens, and harsh temporal variations between the two states. Opposite patterns of spatial and temporal variability were found for the midlittoral assemblages. Despite an overall clear pattern of seagrass regression through time, protected meadows showed a significantly higher shoot density than unprotected ones, suggesting a higher resistance to local human activities. Our results support the assumption that the exclusion/management of human activities within MPAs enhance the stability of the structural components of protected marine systems, reverting or arresting threat-induced trajectories of change. PMID:24349135

[Plant protection products and their residues : Aspects of consumer safety in context of the new EU regulations].

PubMed

Banasiak, U; Michalski, B; Pfeil, R; Solecki, R

2010-06-01

The law regulating plant protection products (PPP) in the European Union (EU) was fundamentally revised through the introduction of Regulation (EC) No. 1107/2009 which is due to enter into force on 14 June 2011. EU-wide harmonized maximum residue levels (MRLs) for the active substances of PPP in foods are laid down in Regulation (EC) No. 396/2005 and apply since entry into force of the regulation on 1 September 2008. The goal of both regulations is to strengthen the level of consumer protection. PPP are subject to a strict assessment of active substances, which is regulated at the EU level as well as an authorization procedure in the EU Member States. Prior to application for authorization of a PPP, the active substance(s) it contains must be included in a positive list. Tests regarding the toxicity and residue behavior of PPP must be conducted by the applicant, and the respective documents must be submitted to the authorities for evaluation. Following review of the required data, toxicological threshold values are derived, consumer exposure is assessed, and the risk to health is evaluated. The goal of this evaluation is to ensure that the use of PPP according to good plant protection practice does not have any harmful effects on human health.

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

PubMed Central

Pacher, P.; Mechoulam, R.

2011-01-01

The mammalian body has a highly developed immune system which guards against continuous invading protein attacks and aims at preventing, attenuating or repairing the inflicted damage. It is conceivable that through evolution analogous biological protective systems have been evolved against non-protein attacks. There is emerging evidence that lipid endocannabinoid signaling through cannabinoid 2 (CB2) receptors may represent an example/part of such a protective system/armamentarium. Inflammation/tissue injury triggers rapid elevations in local endocannabinoid levels, which in turn regulate signaling responses in immune and other cells modulating their critical functions. Changes in endocannabinoid levels and/or CB2 receptor expressions have been reported in almost all diseases affecting humans, ranging from cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, auto-immune, lung disorders to pain and cancer, and modulating CB2 receptor activity holds tremendous therapeutic potential in these pathologies. While CB2 receptor activation in general mediates immunosuppressive effects, which limit inflammation and associated tissue injury in large number of pathological conditions, in some disease states activation of the CB2 receptor may enhance or even trigger tissue damage, which will also be discussed alongside the protective actions of the CB2 receptor stimulation with endocannabinoids or synthetic agonists, and the possible biological mechanisms involved in these effects. PMID:21295074

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

PubMed

Pacher, P; Mechoulam, R

2011-04-01

The mammalian body has a highly developed immune system which guards against continuous invading protein attacks and aims at preventing, attenuating or repairing the inflicted damage. It is conceivable that through evolution analogous biological protective systems have been evolved against non-protein attacks. There is emerging evidence that lipid endocannabinoid signaling through cannabinoid 2 (CB₂) receptors may represent an example/part of such a protective system/armamentarium. Inflammation/tissue injury triggers rapid elevations in local endocannabinoid levels, which in turn regulate signaling responses in immune and other cells modulating their critical functions. Changes in endocannabinoid levels and/or CB₂ receptor expressions have been reported in almost all diseases affecting humans, ranging from cardiovascular, gastrointestinal, liver, kidney, neurodegenerative, psychiatric, bone, skin, autoimmune, lung disorders to pain and cancer, and modulating CB₂ receptor activity holds tremendous therapeutic potential in these pathologies. While CB₂ receptor activation in general mediates immunosuppressive effects, which limit inflammation and associated tissue injury in large number of pathological conditions, in some disease states activation of the CB₂ receptor may enhance or even trigger tissue damage, which will also be discussed alongside the protective actions of the CB₂ receptor stimulation with endocannabinoids or synthetic agonists, and the possible biological mechanisms involved in these effects. Published by Elsevier Ltd.

Progress in Dark Sky Protection in Southern Arizona

NASA Astrophysics Data System (ADS)

Green, Richard F.; Allen, L.; Alvarez Del Castillo, E. M.; Brocious, D. K.; Corbally, C. J.; Davis, D. R.; Falco, E. E.; Gabor, P.; Hall, J. C.; Jannuzi, B.; Larson, S. M.; Mighell, K. J.; Nance, C.; Shankland, P. D.; Walker, C. E.; Williams, G.; Zaritsky, D. F.

2014-01-01

Arizona has many observatories dedicated to scientific research and a rapidly growing population. Continuous interaction with governmental entities and education of the public are required to take advantage of the good intentions of lighting control ordinances in place around the state. We give several recent examples of active engagement of observatories: * Interaction of Mt. Graham International Observatory with the State prison and major copper mine. * Interaction of Smithsonian Astrophysical Observatory, acting on behalf of MMT Observatory and Steward Observatory, with the US Forest Service on the prospects of developing the Rosemont Copper Mine * Defense of the Outdoor Lighting and Sign Codes in Pima County and the City of Tucson * Coordinated observatory approach to statewide issues, including the establishment of radial zones of protection from LED billboards around observatory sites.

Comparison Between Italian and American Mission During Multinational Force II, Beirut 1982-84

DTIC Science & Technology

2002-01-01

Arabic countries complicated the diplomatic efforts because they saw United States diplomacy as an attempt to impose Israeli/Western culture in the...area. But when they were challenged to take a more active role to solve the crisis, the Arab states declined. Apparently no Arab country wanted to...protect the scenes of last year’s massacre and also the Burj -el-Baraineh refugee camp. Highly motorized, like the French, they maintain regular

40 CFR 73.86 - State regulatory autonomy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false State regulatory autonomy. 73.86 Section 73.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... regulatory autonomy. Nothing in this subpart shall preclude a State or State regulatory authority from...

An ecological framework for informing permitting decisions on scientific activities in protected areas

PubMed Central

Saarman, Emily T.; Owens, Brian; Murray, Steven N.; Weisberg, Stephen B.; Field, John C.; Nielsen, Karina J.

2018-01-01

There are numerous reasons to conduct scientific research within protected areas, but research activities may also negatively impact organisms and habitats, and thus conflict with a protected area’s conservation goals. We developed a quantitative ecological decision-support framework that estimates these potential impacts so managers can weigh costs and benefits of proposed research projects and make informed permitting decisions. The framework generates quantitative estimates of the ecological impacts of the project and the cumulative impacts of the proposed project and all other projects in the protected area, and then compares the estimated cumulative impacts of all projects with policy-based acceptable impact thresholds. We use a series of simplified equations (models) to assess the impacts of proposed research to: a) the population of any targeted species, b) the major ecological assemblages that make up the community, and c) the physical habitat that supports protected area biota. These models consider both targeted and incidental impacts to the ecosystem and include consideration of the vulnerability of targeted species, assemblages, and habitats, based on their recovery time and ecological role. We parameterized the models for a wide variety of potential research activities that regularly occur in the study area using a combination of literature review and expert judgment with a precautionary approach to uncertainty. We also conducted sensitivity analyses to examine the relationships between model input parameters and estimated impacts to understand the dominant drivers of the ecological impact estimates. Although the decision-support framework was designed for and adopted by the California Department of Fish and Wildlife for permitting scientific studies in the state-wide network of marine protected areas (MPAs), the framework can readily be adapted for terrestrial and freshwater protected areas. PMID:29920527

Commercial Activities in Schools: Use of Student Data Is Limited and Additional Dissemination of Guidance Could Help Districts Develop Policies. Report to Congressional Requesters. GAO-04-810.

ERIC Educational Resources Information Center

Shaul, Marnie S.

2004-01-01

This study examined (1) the extent to which, since 2000, states have enacted and proposed statutes and regulations to govern commercial activities in schools; (2) the extent to which districts have developed policies implementing amended provisions of the Protection of Pupil Rights Amendment (PPRA) in the No Child Left Behind Act on the use of…

77 FR 32901 - State Enforcement of Household Goods Consumer Protection

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

... enforce certain consumer protection provisions of Title 49 of the United States Code (U.S.C.) and related... bring civil actions in the U.S. district courts to enforce the consumer protection provisions that apply..., 386, and 387 State Enforcement of Household Goods Consumer Protection AGENCY: Federal Motor Carrier...

75 FR 78338 - Meeting of the United States-Oman Joint Forum on Environmental Cooperation Pursuant to the United...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

... environmental protection, (e) Integrated water resources management and protection, (f) Coastal protection and... protected areas. The Department of the Interior, the Environmental Protection Agency, the United States...

40 CFR 60.4140 - State trading budgets.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 6 2011-07-01 2011-07-01 false State trading budgets. 60.4140 Section 60.4140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Electric Steam Generating Units Hg Allowance Allocations § 60.4140 State trading budgets. The State trading...

40 CFR 59.697 - State actions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false State actions. 59.697 Section 59.697 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... State actions. The provisions in this subpart do not preclude any State or any political subdivision of...

Bioeconomic analysis supports the endangered species act.

PubMed

Salau, Kehinde R; Fenichel, Eli P

2015-10-01

The United States Endangered Species Act (ESA) was enacted to protect and restore declining fish, wildlife, and plant populations. The ESA mandates endangered species protection irrespective of costs. This translates to the restriction of activities that harm endangered populations. We discuss criticisms of the ESA in the context of public land management and examine under what circumstance banning non-conservation activity on multiple use federal lands can be socially optimal. We develop a bioeconomic model to frame the species management problem under the ESA and identify scenarios where ESA-imposed regulations emerge as optimal strategies. Results suggest that banning harmful activities is a preferred strategy when valued endangered species are in decline or exposed to poor habitat quality. However, it is not optimal to sustain such a strategy in perpetuity. An optimal plan involves a switch to land-use practices characteristic of habitat conservation plans.

Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor

PubMed Central

Ohmura, Tomomi; Tian, Yufeng; Sarich, Nicolene; Ke, Yunbo; Meliton, Angelo; Shah, Alok S.; Andreasson, Katrin; Birukov, Konstantin G.; Birukova, Anna A.

2017-01-01

The role of prostaglandin A2 (PGA2) in modulation of vascular endothelial function is unknown. We investigated effects of PGA2 on pulmonary endothelial cell (EC) permeability and inflammatory activation and identified a receptor mediating these effects. PGA2 enhanced the EC barrier and protected against barrier dysfunction caused by vasoactive peptide thrombin and proinflammatory bacterial wall lipopolysaccharide (LPS). Receptor screening using pharmacological and molecular inhibitory approaches identified EP4 as a novel PGA2 receptor. EP4 mediated barrier-protective effects of PGA2 by activating Rap1/Rac1 GTPase and protein kinase A targets at cell adhesions and cytoskeleton: VE-cadherin, p120-catenin, ZO-1, cortactin, and VASP. PGA2 also suppressed LPS-induced inflammatory signaling by inhibiting the NFκB pathway and expression of EC adhesion molecules ICAM1 and VCAM1. These effects were abolished by pharmacological or molecular inhibition of EP4. In vivo, PGA2 was protective in two distinct models of acute lung injury (ALI): LPS-induced inflammatory injury and two-hit ALI caused by suboptimal mechanical ventilation and injection of thrombin receptor–activating peptide. These protective effects were abolished in mice with endothelial-specific EP4 knockout. The results suggest a novel role for the PGA2–EP4 axis in vascular EC protection that is critical for improvement of pathological states associated with increased vascular leakage and inflammation. PMID:28428256

76 FR 28792 - Agency Information Collection Activities: Proposed Collection: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration Agency... States Code, as amended by the Paperwork Reduction Act of 1995, Pub. L. 104-13), the Health Resources and... instruments, e-mail [email protected] or call the HRSA Reports Clearance Officer at (301) 443-1129. Comments...

Approach to developing numeric water quality criteria for coastal waters: a transition from SeaWiFS to MODIS and MERIS satellites.

EPA Science Inventory

Human activities on land increase nutrient loads to coastal waters, which can increase phytoplankton production and biomass and potentially cause harmful ecological effects. States can adopt numeric water quality criteria into their water quality standards to protect the designa...

75 FR 81643 - Hydropower Resource Assessment at Existing Reclamation Facilities-Draft Report

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-28

[email protected] . The Draft Report is also accessible from the following Web site: http://www.usbr.gov/power... or about 48.4 billion pounds of coal. Reclamation is the second largest producer of hydroelectric power in the United States, and is actively engaged in looking for opportunities to encourage...

Process Control Manual for Aerobic Biological Wastewater Treatment Facilities.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC. Office of Water Programs.

This Environmental Protection Agency (EPA) publication is an operations manual for activated sludge and trickling filter wastewater treatment facilities. The stated purpose of the manual is to provide an on-the-job reference for operators of these two types of treatment plants. The overall objective of the manual is to aid the operator in…

HAZ-ED Classroom Activities for Understanding Hazardous Waste.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC.

The Federal Superfund Program investigates and cleans up hazardous waste sites throughout the United States. Part of this program is devoted to informing the public and involving people in the process of cleaning up hazardous waste sites from beginning to end. The Haz-Ed program was developed to assist the Environmental Protection Agency's (EPA)…

DEVELOPMENT AND USE OF RARE EARTH TRACERS IN THE MODIFIED DRY PARTICLE DEPOSITION SYSTEM (FORMERLY "DUST" CHAMBER)

EPA Science Inventory

This report was submitted in partial fulfillment of Contract 68-D5-0040 by Research Triangle Institute under the sponsorship of the United States Environmental Protection Agency. This report covers a period from October 1, 1996 to September 30, 1999 and includes activities fun...

75 FR 67784 - STP Nuclear Operating Company South Texas Project Electric Generating Station, Units 3 and 4...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-03

.... Mitigation measures, such as operational controls and practices, worker training, use of personal protective... equipment emissions, and fugitive dust caused by earth-moving activities. As stated in the ER for the COL... fugitive dust and vehicle and equipment emissions, including water suppression, covering truck loads and...

75 FR 28034 - National Protection and Programs Directorate; Agency Information Collection Activities: United...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

... enforcement agencies; and the Federal intelligence community to assist in the decisions they make related to... the collection of fingerprints from two prints to 10. The new collection time of 35 seconds, an... overseas posts; other DHS officers; and appropriate officers of the United States intelligence and law...

78 FR 33839 - Access by United States Environmental Protection Agency (EPA) Contractors to Information Claimed...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... health and the environment by regulating air pollution from motor vehicles, engines, and the fuels used... (CBI) Submitted under Clean Air Act (CAA), Title I, Programs and Activities Air, and Title II Emission Standards for Moving Sources, and Act To Prevent Pollution From Ships (APPS) AGENCY: Environmental...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2010 CFR

2010-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2012 CFR

2012-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2011 CFR

2011-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2014 CFR

2014-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

7 CFR 650.21 - Working relations with the U.S. Environmental Protection Agency (EPA) and related State...

Code of Federal Regulations, 2013 CFR

2013-01-01

... standards. (iii) Consider EPA needs in soil survey and land, inventory, and monitoring activities. (iv... EIS's. (v) Advise EPA regarding soils, plant materials, and soil and water conservation techniques..., transport of pesticides, organic matter and fertilizers, and burning of residues or clearing debris. (2) The...

75 FR 57769 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-22

... treatment works (POTWs) and other water pollution control facilities in the United States, as well as an... records cost and technical data associated with POTWs and other water pollution control facilities... mail to: EPA Docket Center, Environmental Protection Agency, Water Docket, 1200 Pennsylvania Ave., NW...

40 CFR 122.27 - Silvicultural activities (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM Permit Application and Special NPDES Program Requirements § 122.27... or after removal of bark held in self-contained bodies of water (mill ponds or log ponds) or stored...

42 CFR 51.21 - Contracts for program operations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and Priorities § 51.21 Contracts for program operations. (a) An eligible P&A system should work... individuals. (b) An eligible P&A system may contract for the operation of all or part of its program with... capacity to perform protection and advocacy activities throughout the State; (2) The eligible P&A system...

Getting the Biggest Bang for Your Buck: Wildlife Monitoring on Shrublands of the Nevada Test Site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hall, Derek B.; Greger, Paul D.

The Nevada Test Site (NTS) covers 3,561 km2 and extends over portions of both the Mojave and Great Basin Deserts. The resulting diverse and complex flora and fauna exhibit elements of both deserts. There are 20 vegetation associations, composed primarily of shrubs, nested within 10 vegetation alliances. Of the more than 1,200 invertebrate and 339 vertebrate species found in these shrubland habitats, 267 are considered sensitive or protected/regulated by federal or state laws. Wildlife and wildlife habitat monitoring ensures NTS activities comply with all federal and state laws enacted for the protection of these valuable biological resources and provides ecologicalmore » information that can be used to predict and evaluate the potential impacts of proposed projects and current activities on these resources. This paper describes the monitoring approach used at this large site. Monitoring strategies include conducting preactivity surveys, proactively monitoring sensitive species, monitoring long-term population trends, and collaborating with other agencies and biologists. Ways to make monitoring more efficient and examples of successful monitoring and collaborations are discussed.« less

40 CFR 35.925-4 - State allocation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false State allocation. 35.925-4 Section 35.925-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.925-4 State...

40 CFR 35.925-4 - State allocation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false State allocation. 35.925-4 Section 35.925-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.925-4 State...

40 CFR 40.115-6 - State.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false State. 40.115-6 Section 40.115-6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.115-6 State. (a) Under the Federal Water Pollution Control Act, a State, the District...

32 CFR 9.9 - Protection of State secrets.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Protection of State secrets. 9.9 Section 9.9... § 9.9 Protection of State secrets. Nothing in this part shall be construed to authorize disclosure of state secrets to any person not authorized to receive them. ...

32 CFR 9.9 - Protection of State secrets.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Protection of State secrets. 9.9 Section 9.9... § 9.9 Protection of State secrets. Nothing in this part shall be construed to authorize disclosure of state secrets to any person not authorized to receive them. ...

32 CFR 9.9 - Protection of State secrets.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Protection of State secrets. 9.9 Section 9.9... § 9.9 Protection of State secrets. Nothing in this part shall be construed to authorize disclosure of state secrets to any person not authorized to receive them. ...

32 CFR 9.9 - Protection of State secrets.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Protection of State secrets. 9.9 Section 9.9... § 9.9 Protection of State secrets. Nothing in this part shall be construed to authorize disclosure of state secrets to any person not authorized to receive them. ...

32 CFR 9.9 - Protection of State secrets.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Protection of State secrets. 9.9 Section 9.9... § 9.9 Protection of State secrets. Nothing in this part shall be construed to authorize disclosure of state secrets to any person not authorized to receive them. ...

[Mother and child attention in Mexico between 1921 and 1930 abstract by the Department of Public Health].

PubMed

Espinosa de los Reyes-Sánchez, Víctor Manuel

2016-01-01

A series of actions during the years of 1921-1930 took place in Mexico City by the Department of Health in order to protect the women during the gravid puerperal state and the product of conception through the different stages. These activities were initiated based on a work presented in 1921 by Dr. Isidro Espinosa de los Reyes during the Child´s First Mexican Congress sponsored by the newspaper El Universal. In this work entitled "Childcare Intrauterine", the author proposes the foundation of pre- and post-birth clinics, with the intention of protecting the mother and fetus, increasing the birth rate, as well as improving the physical conditions of those born. These clinics were given the name of Hygiene Centers and under the supervision of Dr. Espinosa de los Reyes eight centers were founded, the first one in 1921 and the last one in 1930. The work contains, in full, the activities undertaken to protect the mother and child during the decade indicated.

Workers safety in public psychiatric services: problems, laws and protections.

PubMed

Carabellese, F; Urbano, M; Coluccia, A; Gualtieri, G

2017-01-01

The dramatic case of murder of a psychiatrist during her service in her public office (Centro di Salute Mentale of Bari-Libertà) has led the authors to reflect on the safety of workplaces, in detail of public psychiatric services. It is in the light of current legislation, represented by the Legislative Decree of April 9th, 2008 no. 81, which states the implementing rules of Law 123/2007. In particular, the Authors analyzed the criticalities of the application of this Law, with the aim of safeguarding the health and safety of the workers in all psychiatric services (nursing departments, outpatient clinics, community centers, day care centers, etc.). The Authors suggest the need to set up an articulated specific organizational system of risk assessment of psychiatric services, that can prevent and protect the workers from identified risks, and finally to ensure their active participation in prevention and protection activities, in absence of which specific profiles of responsibility would be opened up to the employers.

Association between Natural Resources for Outdoor Activities and Physical Inactivity: Results from the Contiguous United States.

PubMed

Jiang, Yan; Yuan, Yongping; Neale, Anne; Jackson, Laura; Mehaffey, Megan

2016-08-17

Protected areas including national/state parks and recreational waters are excellent natural resources that promote physical activity and interaction with Nature, which can relieve stress and reduce disease risk. Despite their importance, however, their contribution to human health has not been properly quantified. This paper seeks to evaluate quantitatively how national/state parks and recreational waters are associated with human health and well-being, taking into account of the spatial dependence of environmental variables for the contiguous U.S., at the county level. First, we describe available natural resources for outdoor activities (ANROA), using national databases that include features from the Protected Areas Database, NAVSTREETS, and ATTAINSGEO 305(b) Waters. We then use spatial regression techniques to explore the association of ANROA and socioeconomic status factors on physical inactivity rates. Finally, we use variance analysis to analyze ANROA's influence on income-related health inequality. We found a significantly negative association between ANROA and the rate of physical inactivity: ANROA and the spatial effect explained 69%, nationwide, of the variation in physical inactivity. Physical inactivity rate showed a strong spatial dependence-influenced not only by its own in-county ANROA, but also by that of its neighbors ANROA. Furthermore, community groups at the same income level and with the highest ANROA, always had the lowest physical inactivity rate. This finding may help to guide future land use planning and community development that will benefit human health and well-being.

Antimicrobial resistance surveillance in the AFHSC-GEIS network

PubMed Central

2011-01-01

International infectious disease surveillance has been conducted by the United States (U.S.) Department of Defense (DoD) for many years and has been consolidated within the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) since 1998. This includes activities that monitor the presence of antimicrobial resistance among pathogens. AFHSC-GEIS partners work within DoD military treatment facilities and collaborate with host-nation civilian and military clinics, hospitals and university systems. The goals of these activities are to foster military force health protection and medical diplomacy. Surveillance activities include both community-acquired and health care-associated infections and have promoted the development of surveillance networks, centers of excellence and referral laboratories. Information technology applications have been utilized increasingly to aid in DoD-wide global surveillance for diseases significant to force health protection and global public health. This section documents the accomplishments and activities of the network through AFHSC-GEIS partners in 2009. PMID:21388568

Antimicrobial resistance surveillance in the AFHSC-GEIS network.

PubMed

Meyer, William G; Pavlin, Julie A; Hospenthal, Duane; Murray, Clinton K; Jerke, Kurt; Hawksworth, Anthony; Metzgar, David; Myers, Todd; Walsh, Douglas; Wu, Max; Ergas, Rosa; Chukwuma, Uzo; Tobias, Steven; Klena, John; Nakhla, Isabelle; Talaat, Maha; Maves, Ryan; Ellis, Michael; Wortmann, Glenn; Blazes, David L; Lindler, Luther

2011-03-04

International infectious disease surveillance has been conducted by the United States (U.S.) Department of Defense (DoD) for many years and has been consolidated within the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) since 1998. This includes activities that monitor the presence of antimicrobial resistance among pathogens. AFHSC-GEIS partners work within DoD military treatment facilities and collaborate with host-nation civilian and military clinics, hospitals and university systems. The goals of these activities are to foster military force health protection and medical diplomacy. Surveillance activities include both community-acquired and health care-associated infections and have promoted the development of surveillance networks, centers of excellence and referral laboratories. Information technology applications have been utilized increasingly to aid in DoD-wide global surveillance for diseases significant to force health protection and global public health. This section documents the accomplishments and activities of the network through AFHSC-GEIS partners in 2009.

Mobilization and Defense Management Technical Reports Series. Acquisition of ADP (Automated Data Processing) by the Army during Mobilization.

DTIC Science & Technology

1983-03-01

have both a Federal and a State mission. The State mission is to provide protection of life and property and to preserve peace and public safety. The...logistics system is basically the same and will be integrated into the active system in wartime. Financial man- agement support consists of financial...the entire system is security. ErS is on contract to furnish basic security as well as a higher type of security known as the enhanced version

IFN-ε protects primary macrophages against HIV infection.

PubMed

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan; Chang, Theresa L

2016-12-08

IFN-ε is a unique type I IFN that is not induced by pattern recognition response elements. IFN-ε is constitutively expressed in mucosal tissues, including the female genital mucosa. Although the direct antiviral activity of IFN-ε was thought to be weak compared with IFN-α, IFN-ε controls Chlamydia muridarum and herpes simplex virus 2 in mice, possibly through modulation of immune response. We show here that IFN-ε induces an antiviral state in human macrophages that blocks HIV-1 replication. IFN-ε had little or no protective effect in activated CD4 + T cells or transformed cell lines unless activated CD4 + T cells were infected with replication-competent HIV-1 at a low MOI. The block to HIV infection of macrophages was maximal after 24 hours of treatment and was reversible. IFN-ε acted on early stages of the HIV life cycle, including viral entry, reverse transcription, and nuclear import. The protection did not appear to operate through known type I IFN-induced HIV host restriction factors, such as APOBEC3A and SAMHD1. IFN-ε-stimulated immune mediators and pathways had the signature of type I IFNs but were distinct from IFN-α in macrophages. IFN-ε induced significant phagocytosis and ROS, which contributed to the block to HIV replication. These findings indicate that IFN-ε induces an antiviral state in macrophages that is mediated by different factors than those induced by IFN-α. Understanding the mechanism of IFN-ε-mediated HIV inhibition through immune modulation has implications for prevention.

IFN-ε protects primary macrophages against HIV infection

PubMed Central

Tasker, Carley; Subbian, Selvakumar; Gao, Pan; Couret, Jennifer; Levine, Carly; Ghanny, Saleena; Soteropoulos, Patricia; Zhao, Xilin; Landau, Nathaniel; Lu, Wuyuan

2016-01-01

IFN-ε is a unique type I IFN that is not induced by pattern recognition response elements. IFN-ε is constitutively expressed in mucosal tissues, including the female genital mucosa. Although the direct antiviral activity of IFN-ε was thought to be weak compared with IFN-α, IFN-ε controls Chlamydia muridarum and herpes simplex virus 2 in mice, possibly through modulation of immune response. We show here that IFN-ε induces an antiviral state in human macrophages that blocks HIV-1 replication. IFN-ε had little or no protective effect in activated CD4+ T cells or transformed cell lines unless activated CD4+ T cells were infected with replication-competent HIV-1 at a low MOI. The block to HIV infection of macrophages was maximal after 24 hours of treatment and was reversible. IFN-ε acted on early stages of the HIV life cycle, including viral entry, reverse transcription, and nuclear import. The protection did not appear to operate through known type I IFN-induced HIV host restriction factors, such as APOBEC3A and SAMHD1. IFN-ε–stimulated immune mediators and pathways had the signature of type I IFNs but were distinct from IFN-α in macrophages. IFN-ε induced significant phagocytosis and ROS, which contributed to the block to HIV replication. These findings indicate that IFN-ε induces an antiviral state in macrophages that is mediated by different factors than those induced by IFN-α. Understanding the mechanism of IFN-ε–mediated HIV inhibition through immune modulation has implications for prevention. PMID:27942584

Phenolic Content of Hypodaphnis Zenkeri and Its Antioxidant Effects against Fenton Reactions’ Mediated Oxidative Injuries on Liver Homogenate

PubMed Central

Moukette Moukette, Bruno; Pieme, Constant Anatole; Nya Biapa, Prosper Cabral; Njimou, Jacques Romain; Ama Moor, Vicky Jocelyne; Stoller, Marco; Bravi, Marco; Ngogang, Jeanne Yonkeu

2014-01-01

Under oxidative stress conditions, endogenous antioxidant defenses are unable to completely inactivate the free radicals generated by an excessive production of reactive oxygen species (ROS). This state causes serious cell damage leading to a variety of human diseases. Natural antioxidants can protect cells against oxidative stress. Hypaodaphnis zenkeri (H. zenkiri) is a plant consumed as a spice in the Cameroonian diet, and its bark has been used in traditional medicine for the treatment of several diseases. The present study aims at investigating the antioxidant activity, which includes free radical scavenging and protective properties of an extract from H. Zenkiri against oxidative damage on a liver homogenate. The free radical assays determined the scavenging activities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (OH), nitrite oxide (NO) and 2,2-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radicals and the enzymes, whose protection was to be considered in the liver homogenate, including superoxide dismutase, catalase, and peroxidase. The antioxidative activities were studied using the ferric reducing antioxidant power (FRAP), reductive activity, and phosphomolybdenum antioxidant power (PAP) methods. In addition, the phenolic contents of the extracts were examined. The results showed that these extracts demonstrated significant scavenging properties and antioxidant activities, with the hydro-ethanolic extract of the bark of H. zenkeri (EEH) being the most potent. This extract had the highest total polyphenol (21.77 ± 0.05 mg caffeic acid (CAE)/g dried extract (DE)) and flavonoids (3.34 ± 0.13 mg quercetin (QE)/g dried extract) content. The same extract had significantly greater protective effects on enzyme activities compared to other extracts. The high performance liquied chromatography (HPLC) profile showed higher levels of caffeic acid, OH-tyrosol acid, and rutin in the leaves compared to the bark of H. zenkeri. In conclusion, the ethanolic and hydro-ethanolic extracts of the bark and leaves from H. zenkeri showed an antioxidant and protective potential against oxidative damage. PMID:26785245

In vitro study on antioxidant potential of various drugs used in the perioperative period.

PubMed

Kang, M Y; Tsuchiya, M; Packer, L; Manabe, M

1998-01-01

Since surgical trauma not only intensifies the oxidative stress by generating reactive oxygen species (ROS), but also weakens the biological defense system against ROS attack, the antioxidant activity of drugs used during the perioperative period, which possibly normalizes the impaired redox state in the patient, is of fundamental importance and great clinical interest. We have applied the phycoerythrin fluorescence-based assay, in which 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-generated peroxyl radical attacks B-phycoerythrin (B-PE) to lead to a sensitive decrease in its fluorescence intensity linearly, to evaluate the antioxidant activity of major drugs in anesthetic practice. By the protective effect on B-PE fluorescence decay, the antioxidant activities of the drugs were classified into three groups: Group I drugs, which only slowed B-PE fluorescence decay (nicardipine, verapamil, diltiazem, ephedrine, aminophylline, vecuronium, lidocaine, mepivacaine, midazolam, thiamylal, droperidol, ketamine, hydroxyzine, butorphanol, prednisolone, hydrocortisone, betamethasone, dexamethasone, methylprednisolone, and furosemide); Group II drugs, which protected B-PE oxidation completely and stopped fluorescence decay in a certain duration (dopamine, epinephrine, norepinephrine, dobutamine, isoproterenol, and buprenorphine); and Group III drugs, which had no protective effect on B-PE oxidation (nitroglycerin, prostaglandin E1, neostigmine, pancuronium, suxamethonium, atropine, bupivacaine, pentazocine, and heparin). These results indicate that Group I and II drugs exert some antioxidant activity in vitro, as measured by their protection of fluorescence decay of B-PE. Careful consideration of these properties might, then, serve to facilitate more efficient drug application.

The role of microbial low-molecular-weight autoregulatory factors (alkylhydroxybenzenes) in resistance of microorganisms to radiation

NASA Astrophysics Data System (ADS)

El-Registan, G. I.; Mulyukin, A. L.; Nikolaev, Yu. A.; Stepanenko, I. Yu.; Shanenko, E. A.; Strakhovskaya, M. G.; Revina, A. A.

Low-molecular-weight cell-to-cell communication factors are produced by various pro- and eukaryotes and involved in autoregulation of the growth and development of microbial cultures. As for some bacterial and yeast species, these factors were identified as isomers and homologs of alkylhydroxybenzenes (AHBs). Depending on the concentration, they participate in controlling the transition to stationary phase, entering the resting state, and stress resistance of vegetative cells to gamma-irradiation, photooxidation (singlet oxygen), heat shock. Chemical analogs of microbial AHBs protected microbial cultures from stressful situations and prolonged starvation and exerted (1) the stabilizing activity toward biomacromolecules and supermolecular structures (cell membranes) and (2) the ability to scavenge active oxygen species. The stabilizing effect of AHBs as chemical chaperones resulted from their complex formation with protected macromolecules due to intermolecular hydrogen bonds, hydrophobic and electrostatic interactions and was demonstrated on models of individual enzymes (trypsin, amylase, etc.). The action of AHBs as active oxygen species scavengers was related to their oxidative conversion to water-insoluble polymeric products. Particularly, AHBs protected the yeast from the action of (a) active oxygen species formed during gamma-irradiation (50 krad, 196 rad/sec) or (b) singlet oxygen generated in cells photosensitized by chlorin e6 (10 mkg/L). It is important that microbial AHBs were not species-specific and defended cultured animal cells (ras-transformed fibroblasts) from the action of organic toxicants. The use of AHBs as protectants and adaptogens will be discussed as well as perspectives of further investigations.

Select state inland wetland protection laws. A review of the state laws and their natural resource data requirements

NASA Technical Reports Server (NTRS)

Klein, S. B.

1980-01-01

Although many states afford some measure of protection for wetland areas through flood-plain regulations or through programs for coastal areas, shorelands, scenic and wild rivers or pollution control, few states have programs that adequately deal with conservation of wetlands. Only 16 states have legislation specifically regulating development or use of wetlands. Most of the wetland acts apply only to coastal wetlands, several to inland wetlands and three acts apply to both. Many other states are still regulating wetland use through the dredge and fill and/or critical area program. Several offer tax incentives to property owners to encourage protection of wetlands or broader open spaces. Many states have acquired wetlands for park and wildlife purposes and a large measure of wetland protection is achieved by the very restrictive controls applied to floodways areas. Direct floodplain or floodway regulations or state standards for local regulations were adopted in 24 states but protection of ecological values of wetlands is rarely an explicit objective of these programs. Scenic and wild river programs adopted in one half of the states provide some protection for wetland areas.

Investigating the effect of moisture protection on solid-state stability and dissolution of fenofibrate and ketoconazole solid dispersions using PXRD, HSDSC and Raman microscopy.

PubMed

Kanaujia, Parijat; Lau, Grace; Ng, Wai Kiong; Widjaja, Effendi; Schreyer, Martin; Hanefeld, Andrea; Fischbach, Matthias; Saal, Christoph; Maio, Mario; Tan, Reginald B H

2011-09-01

Enhanced dissolution of poorly soluble active pharmaceutical ingredients (APIs) in amorphous solid dispersions often diminishes during storage due to moisture-induced re-crystallization. This study aims to investigate the influence of moisture protection on solid-state stability and dissolution profiles of melt-extruded fenofibrate (FF) and ketoconazole (KC) solid dispersions. Samples were kept in open, closed and Activ-vials(®) to control the moisture uptake under accelerated conditions. During 13-week storage, changes in API crystallinity were quantified using powder X-ray diffraction (PXRD) (Rietveld analysis) and high sensitivity differential scanning calorimetry (HSDSC) and compared with any change in dissolution profiles. Trace crystallinity was observed by Raman microscopy, which otherwise was undetected by PXRD and HSDSC. Results showed that while moisture protection was ineffective in preventing the re-crystallization of amorphous FF, KC remained X-ray amorphous despite 5% moisture uptake. Regardless of the degree of crystallinity increase in FF, the enhanced dissolution properties were similarly diminished. Moisture uptake above 10% in KC samples also led to re-crystallization and significant decrease in dissolution rates. In conclusion, eliminating moisture sorption may not be sufficient in ensuring the stability of solid dispersions. Analytical quantification of API crystallinity is crucial in detecting subtle increase in crystallinity that can diminish the enhanced dissolution properties of solid dispersions.

Enzymatic Removal of Diacetyl from Beer 1

PubMed Central

Thompson, Janet W.; Shovers, J.; Sandine, W. E.; Elliker, P. R.

1970-01-01

Use of diacetyl reductase, a reduced nicotinamide adenine dinucleotide (NADH)-requiring enzyme, to eliminate diacetyl off-flavor in beer was studied. The crude enzyme was extracted from Aerobacter aerogenes and partially purified by ammonium sulfate precipitation or Sephadex chromatography. In the semipure state, the enzyme was inactivated by lyophilization; in a crude state, the lyophilized extract remained stable for at least 4 months at — 20 C. A 50% reduction in specific activity within 5 min was observed when crude diacetyl reductase was suspended (5 mg of protein/ml) in phosphate buffer at pH 5.5 or below; a similar inactivation rate was observed when the crude enzyme was dissolved in a 5% aqueous ethyl alcohol solution. Effective crude enzyme activity in beer at a natural pH of 4.1 required protection of the enzyme in 10% gelatin. Incorporation of yeast cells with the gel-protected enzyme provided regeneration of NADH. Combinations of yeast, enzyme, and gelatin were tested to obtain data analyzed by regression analysis to determine the optimal concentration of each component of the system required to reduce the level of diacetyl in spiked (0.5 ppm) beer to less than 0.12 ppm within 48 hr at 5 C. The protected enzyme system was also effective in removing diacetyl from orange juice (pH 3.8) and some distilled liquors. PMID:4318450

INVENTORY OF MOSQUITOES (DIPTERA: CULICIDAE) IN CONSERVATION UNITS IN BRAZILIAN TROPICAL DRY FORESTS.

PubMed

Santos, Cleandson Ferreira; Silva, Alex Chavier; Rodrigues, Raquel Andrade; de Jesus, Jamilli Sanndy Ramos; Borges, Magno Augusto Zazá

2015-01-01

In Brazil, most studies of the Culicidae family are concentrated in rainforest regions. As such, there is a lack of knowledge regarding the diversity of Culicidae in regions with different climatic and vegetational characteristics. The aim of this study was to compile an inventory of Culicidae in protected areas of the semi-arid region of the state of Minas Gerais, Brazil, in order to better understand the diversity of the family within this region. The study was conducted across four protected areas in the northern region of the state, in tropical dry forest (TDF) fragments. Sampling methods included Shannon trap and CDC light trap, as well as active collection. A total of 11,219 mosquito specimens were collected between August 2008 and July 2012, belonging to 11 genera and 45 species; 15 new records for the state of Minas Gerais were registered, as well as 26 new records for semi-arid regions within the state. The high number of new Culicidae records in this region demonstrates the importance of inventory studies for increasing the knowledge of culicid biodiversity in Minas Gerais, and in particular within semi-arid regions of the state.

Protein kinase C-ε activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules

PubMed Central

Bakajsova, Diana; Samarel, Allen M.

2011-01-01

PKC-ε activation mediates protection from ischemia-reperfusion injury in the myocardium. Mitochondria are a subcellular target of these protective mechanisms of PKC-ε. Previously, we have shown that PKC-ε activation is involved in mitochondrial dysfunction in oxidant-injured renal proximal tubular cells (RPTC; Nowak G, Bakajsova D, Clifton GL Am J Physiol Renal Physiol 286: F307–F316, 2004). The goal of this study was to examine the role of PKC-ε activation in mitochondrial dysfunction and to identify mitochondrial targets of PKC-ε in RPTC. The constitutively active and inactive mutants of PKC-ε were overexpressed in primary cultures of RPTC using the adenoviral technique. Increases in active PKC-ε levels were accompanied by PKC-ε translocation to mitochondria. Sustained PKC-ε activation resulted in decreases in state 3 respiration, electron transport rate, ATP production, ATP content, and activities of complexes I and IV and F0F1-ATPase. Furthermore, PKC-ε activation increased mitochondrial membrane potential and oxidant production and induced mitochondrial fragmentation and RPTC death. Accumulation of the dynamin-related protein in mitochondria preceded mitochondrial fragmentation. Antioxidants blocked PKC-ε-induced increases in the oxidant production but did not prevent mitochondrial fragmentation and cell death. The inactive PKC-ε mutant had no effect on mitochondrial functions, morphology, oxidant production, and RPTC viability. We conclude that active PKC-ε targets complexes I and IV and F0F1-ATPase in RPTC. PKC-ε activation mediates mitochondrial dysfunction, hyperpolarization, and fragmentation. It also induces oxidant generation and cell death, but oxidative stress is not the mechanism of RPTC death. These results show that in contrast to protective effects of PKC-ε activation in cardiomyocytes, sustained PKC-ε activation is detrimental to mitochondrial function and viability in RPTC. PMID:21289057

The women preachers of the secular state: the politics of preaching at the intersection of gender, ethnicity and sovereignty in Turkey.

PubMed

Tütüncü, Fatma

2010-01-01

This article analyzes the politics of preaching in Turkey in the last decade by focusing on the appointment of women as preachers and vice-muftis by the Turkish Presidency of Religious Affairs (Diyanet), a state institution established for the protection of secular foundations through religious service. It asks what happens when women wearing headscarves become civil servants and give religious guidance in a secular state, which prohibits headscarves in public offices and schools. It shows that the context, the use and the interlocutors of preaching make ordinary religious activity a complicated political practice that interacts with gender, ethnicity and state sovereignty. It argues that exceptional integration of headscarved women into public offices would seem to be an achievement given the long lasting political activism of women over the headscarf, but in the final analysis it serves the sovereign power of the state, which aims to absorb both Islamist and Kurdish challenges by mobilizing women preachers.

Watchdog activity monitor (WAM) for use wth high coverage processor self-test

NASA Technical Reports Server (NTRS)

Tulpule, Bhalchandra R. (Inventor); Crosset, III, Richard W. (Inventor); Versailles, Richard E. (Inventor)

1988-01-01

A high fault coverage, instruction modeled self-test for a signal processor in a user environment is disclosed. The self-test executes a sequence of sub-tests and issues a state transition signal upon the execution of each sub-test. The self-test may be combined with a watchdog activity monitor (WAM) which provides a test-failure signal in the presence of a counted number of state transitions not agreeing with an expected number. An independent measure of time may be provided in the WAM to increase fault coverage by checking the processor's clock. Additionally, redundant processor systems are protected from inadvertent unsevering of a severed processor using a unique unsever arming technique and apparatus.

Aeronautics and Space Report of the President

NASA Technical Reports Server (NTRS)

1991-01-01

The years 1989 to 1990 activities are reported including human space flight, unmanned expendable launch vehicles, space science and applications, space communications operations, space research and technology, and aeronautics research and technology. Contributions made by the 14 participating government organizations are outline. Each organization's aeronautics and/or space activities for the year are presented. The organizations involved include: (1) NASA; (2) Dept. of Defense; (3) Dept. of Commerce; (4) Dept. of Energy; (5) Dept. of the Interior; (6) Dept. of Agriculture; (7) Federal Communications Commission; (8) Dept. of Transportation; (9) Environmental Protection Agency; (10) National Science Foundation; (11) Smithsonian Institution; (12) Dept. of State; (13) Arms Control and Disarmament; and (14) United States Information Agency.

Adoption of rollover protective structures (ROPS) on U.S. farm tractors by state: 1993-1995, 2001, and 2004.

PubMed

Hard, D L; Myers, J R

2011-04-01

This research compares state-level rollover protective structure (ROPS) prevalence rates from the early and mid-1990s to those observed in the years 2001 and 2004. In addition, state-level ROPS prevalence rates are compared to state-level tractor overturn fatality rates. Tractor data for 1993-1995 and for 2001 and 2004 for all tractors and ROPS-equipped tractors in use on U.S. farms were derived from surveys conducted for NIOSH by the USDA-NASS. Changes in ROPS prevalence rates at the state level between the two time periods were assessed using a two-sample paired t-test with unequal sample sizes. Poisson regression was used to assess the association between ROPS prevalence rates and tractor overturn fatality rates at the state level. Overall, 49 of the 50 states had an observed increase in the percentage of farm tractors equipped with ROPS from 1993-1995 to 2001 and 2004. This increase was statistically significant for 34 states. Large shifts in ROPS prevalence were found within individual states and in clusters of states. These include a major increase in the southeastern U.S. and some western states. However, a core of states in the northeast (many of them in or near the Appalachian Mountains) through the upper midwest remain in the bottom quartile for ROPS prevalence. For the years 1992 through 2004, the highest fatality rates were observed in many of the same states that were identified previously as having persistently low ROPS prevalence rates. There is a clear relationship between low state-level ROPS prevalence rates and high state-specific tractor overturn fatality rates. While progress has been made in increasing the percentage of ROPS-equipped farm tractors, it is projected that ROPS prevalence rates will not reach a protective level nationally until after 2015. Regionally, the northeast and midwest will not reach protective levels of ROPS-equipped tractors until after 2020. Based on the adoption rates observed, tractor overturn rates will likely continue to be a more localized, but significant, public health issue for several states beyond the year 2020. The results of this study show the geographic areas of the U.S. where the greatest need exists, and where a greater emphasis should be placed on ROPS promotion activities. However, addressing this public health issue on a large scale will require resources and an organized commitment, which have historically been lacking.

40 CFR 122.28 - General permits (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false General permits (applicable to State NPDES programs, see § 123.25). 122.28 Section 122.28 Protection of Environment ENVIRONMENTAL PROTECTION...) City, county, or State political boundaries; (iv) State highway systems; (v) Standard metropolitan...

40 CFR 122.28 - General permits (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true General permits (applicable to State NPDES programs, see § 123.25). 122.28 Section 122.28 Protection of Environment ENVIRONMENTAL PROTECTION...) City, county, or State political boundaries; (iv) State highway systems; (v) Standard metropolitan...

40 CFR 122.28 - General permits (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false General permits (applicable to State NPDES programs, see § 123.25). 122.28 Section 122.28 Protection of Environment ENVIRONMENTAL PROTECTION...) City, county, or State political boundaries; (iv) State highway systems; (v) Standard metropolitan...

40 CFR 122.28 - General permits (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false General permits (applicable to State NPDES programs, see § 123.25). 122.28 Section 122.28 Protection of Environment ENVIRONMENTAL PROTECTION...) City, county, or State political boundaries; (iv) State highway systems; (v) Standard metropolitan...

“Protective Bystander Effects Simulated with the State-Vector Model”—HeLa x Skin Exposure to 137Cs Not Protective Bystander Response But Mammogram and Diagnostic X-Rays Are

PubMed Central

Leonard, Bobby E.

2008-01-01

The recent Dose Response journal article “Protective Bystander Effects Simulated with the State-Vector Model” (Schollnberger and Eckl 2007) identified the suppressive (below natural occurring, zero primer dose, spontaneous level) dose response for HeLa x skin exposure to 137Cs gamma rays (Redpath et al 2001) as a protective Bystander Effect (BE) behavior. I had previously analyzed the Redpath et al (2001) data with a Microdose Model and conclusively showed that the suppressive response was from Adaptive Response (AR) radio-protection (Leonard 2005, 2007a). The significance of my microdose analysis has been that low LET radiation induced single (i.e. only one) charged particle traversals through a cell can initiate a Poisson distributed activation of AR radio-protection. The purpose of this correspondence is to clarify the distinctions relative to the BE and the AR behaviors for the Redpath groups 137Cs data, show conversely however that the Redpath group data for mammography (Ko et al 2004) and diagnostic (Redpath et al 2003) X-rays do conclusively reflect protective bystander behavior and also herein emphasize the need for radio-biologist to apply microdosimetry in planning and analyzing their experiments for BE and AR. Whether we are adamantly pro-LNT, adamantly anti-LNT or, like most of us, just simple scientists searching for the truth in radio-biology, it is important that we accurately identify our results, especially when related to the LNT hypothesis controversy. PMID:18846260

Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation

PubMed Central

Yu, Liming; Di, Wencheng; Dong, Xue; Li, Zhi; Xue, Xiaodong; Zhang, Jian; Wang, Qi; Xiao, Xiong; Han, Jinsong; Yang, Yang; Wang, Huishan

2017-01-01

Diallyl trisulfide (DATS), the major active ingredient in garlic, has been reported to confer cardioprotective effects. However, its effect on myocardial ischemia-reperfusion (MI/R) injury in diabetic state and the underlying mechanism are still unknown. We hypothesize that DATS reduces MI/R injury in diabetic state via AMPK-mediated AKT/GSK-3β/HIF-1α activation. Streptozotocin-induced diabetic rats received MI/R surgery with or without DATS (20mg/kg) treatment in the presence or absence of Compound C (Com.C, an AMPK inhibitor, 0.25mg/kg) or LY294002 (a PI3K inhibitor, 5mg/kg). We found that DATS significantly improved heart function and reduced myocardial apoptosis. Additionally, in cultured H9c2 cells, DATS (10μM) also attenuated simulated ischemia-reperfusion injury. We found that AMPK and AKT/GSK-3β/HIF-1α signaling were down-regulated under diabetic condition, while DATS markedly increased the phosphorylation of AMPK, ACC, AKT and GSK-3β as well as HIF-1α expression in MI/R-injured myocardium. However, these protective actions were all blunted by Com.C administration. Additionally, LY294002 abolished the stimulatory effect of DATS on AKT/GSK-3β/HIF-1α signaling without affecting AMPK signaling. While 2-methoxyestradiol (a HIF-1α inhibitor) reduced HIF-1α expression without affecting AKT/GSK-3β signaling. Taken together, these data showed that DATS protected against MI/R injury in diabetic state by attenuating cellular apoptosis via AMPK-mediated AKT/GSK-3β/HIF-1α signaling. Its cardioprotective effect deserves further study. PMID:29088824

40 CFR 147.1200 - State-administered program. [Reserved

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 24 2013-07-01 2013-07-01 false State-administered program. [Reserved] 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota...

40 CFR 147.1200 - State-administered program. [Reserved

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State-administered program. [Reserved] 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota...

40 CFR 147.1200 - State-administered program. [Reserved

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 24 2012-07-01 2012-07-01 false State-administered program. [Reserved] 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota...

40 CFR 147.1200 - State-administered program. [Reserved

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 23 2014-07-01 2014-07-01 false State-administered program. [Reserved] 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota...

40 CFR 147.1200 - State-administered program. [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. [Reserved] 147.1200 Section 147.1200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Minnesota...

40 CFR 147.600 - State-administered program. [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. [Reserved] 147.600 Section 147.600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Hawaii...

40 CFR 501.18 - Prohibition.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Prohibition. 501.18 Section 501.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STATE SLUDGE MANAGEMENT PROGRAM REGULATIONS Development and Submission of State Programs § 501.18 Prohibition. State permit...

MO-E-213-02: Medical Physicist Involvement in Implementing Patient Protection Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seibert, J.

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

MO-E-213-03: Newer Radiation Protection Requirements in Last Decade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, J.

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

MO-E-213-01: Increasing Role of Medical Physicist in Radiation Protection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rehani, M.

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

Comparing hiking, mountain biking and horse riding impacts on vegetation and soils in Australia and the United States of America.

PubMed

Pickering, Catherine Marina; Hill, Wendy; Newsome, David; Leung, Yu-Fai

2010-01-01

Hiking, horse riding and mountain biking are popular in protected areas in Australia and the United States of America. To help inform the often contentious deliberations about use of protected areas for these three types of activities, we review recreation ecology research in both countries. Many impacts on vegetation, soils and trails are similar for the three activities, although there can be differences in severity. Impacts include damage to existing trails, soil erosion, compaction and nutrification, changes in hydrology, trail widening, exposure of roots, rocks and bedrock. There can be damage to plants including reduction in vegetation height and biomass, changes in species composition, creation of informal trails and the spread of weeds and plant pathogens. Due to differences in evolutionary history, impacts on soil and vegetation can be greater in Australia than in the USA. There are specific social and biophysical impacts of horses such as those associated with manure and urine, grazing and the construction and use of tethering yards and fences. Mountain bike specific impacts include soil and vegetation damage from skidding and the construction of unauthorised trails, jumps, bridges and other trail technical features. There are gaps in the current research that should be filled by additional research: (1) on horse and mountain bike impacts to complement those on hiking. The methods used need to reflect patterns of actual usage and be suitable for robust statistical analysis; (2) that directly compares types and severity of impacts among activities; and (3) on the potential for each activity to contribute to the spread of weeds and plant pathogens. Additional research will assist managers and users of protected areas in understanding the relative impacts of these activities, and better ways to manage them. It may not quell the debates among users, managers and conservationists, but it will help put it on a more scientific footing. 2009 Elsevier Ltd. All rights reserved.

Cobalt Chloride Upregulates Impaired HIF-1α Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats

PubMed Central

Wu, Jianjiang; Yang, Long; Xie, Peng; Yu, Jin; Yu, Tian; Wang, Haiying; Maimaitili, Yiliyaer; Wang, Jiang; Ma, Haiping; Yang, Yining; Zheng, Hong

2017-01-01

Previous studies from our group have demonstrated that sevoflurane post-conditioning (SPC) protects against myocardial ischemia reperfusion injury via elevating the intranuclear expression of hypoxia inducible factor-1 alpha (HIF-1α). However, diabetic SPC is associated with decreased myocardial protection and disruption of the HIF-1 signaling pathway. Previous studies have demonstrated that cobalt chloride (CoCl2) can upregulate HIF-1α expression under diabetic conditions, but whether myocardial protection by SPC can be restored afterward remains unclear. We established a rat model of type 2 diabetes and a Langendorff isolated heart model of ischemia-reperfusion injury. Prior to reperfusion, 2.4% sevoflurane was used as a post-conditioning treatment. The diabetic rats were treated with CoCl2 24 h before the experiment. At the end of reperfusion, tests were performed to assess myocardial function, infarct size, mitochondrial morphology, nitric oxide (NO), Mitochondrial reactive oxygen species (ROS), mitochondrial respiratory function and enzyme activity, HIF-1α, vascular endothelial growth factor (VEGF) and endothelial NO synthase (eNOS) protein levels. In addition, myocardial protection by SPC was monitored after the blood glucose levels were lowered by insulin. The diabetic state was associated with deficient SPC protection and decreased HIF-1α expression. After treating the diabetic rats with CoCl2, SPC significantly upregulated the expression of HIF-1α, VEGF and eNOS, which markedly improved cardiac function, NO, mitochondrial respiratory function, and enzyme activity and decreased the infarction areas and ROS. In addition, these effects were not influenced by blood glucose levels. This study proved that CoCl2activates the HIF-1α signaling pathway, which restores SPC-dependent myocardial protection under diabetic conditions, and the protective effects of SPC were independent of blood glucose levels. PMID:28659817

Determinants of the Rigor of State Protection Policies for Persons With Dementia in Assisted Living.

PubMed

Nattinger, Matthew C; Kaskie, Brian

2017-01-01

Continued growth in the number of individuals with dementia residing in assisted living (AL) facilities raises concerns about their safety and protection. However, unlike federally regulated nursing facilities, AL facilities are state-regulated and there is a high degree of variation among policies designed to protect persons with dementia. Despite the important role these protection policies have in shaping the quality of life of persons with dementia residing in AL facilities, little is known about their formation. In this research, we examined the adoption of AL protection policies pertaining to staffing, the physical environment, and the use of chemical restraints. For each protection policy type, we modeled policy rigor using an innovative point-in-time approach, incorporating variables associated with state contextual, institutional, political, and external factors. We found that the rate of state AL protection policy adoptions remained steady over the study period, with staffing policies becoming less rigorous over time. Variables reflecting institutional policy making, including legislative professionalism and bureaucratic oversight, were associated with the rigor of state AL dementia protection policies. As we continue to evaluate the mechanisms contributing to the rigor of AL protection policies, it seems that organized advocacy efforts might expand their role in educating state policy makers about the importance of protecting persons with dementia residing in AL facilities and moving to advance appropriate policies.

Synopsis of the history of sea otter conservation in the United States

USGS Publications Warehouse

VanBlaricom, Glenn R.

2015-01-01

In the late 1860s, declining US sea otter populations elicited concern because of prior excessive harvests. Congress mandated protection of Alaskan sea otters in 1868, but hunting continued unrestrained. The Fur Seal Treaty of 1911 (abrogated in 1941) protected sea otters in international waters, but was not applicable to most sea otter habitats and failed to terminate all legal sea otter harvests. Between 1941 and 1972 only the State of California was consistently engaged in sea otter conservation, based on a 1913 state law. Trends in cultural values toward protection of species based on imperiled status rather than economics led to the Marine Mammal Protection Act (1972), giving sea otters unambiguous protection in all US territorial waters. Sea otter habitat protection by the US government began in the 1890s. State marine protected areas potentially support sea otter conservation, particularly when paired with adjacent federal protected entities in or near sea otter habitat.

Maximum allowable exposure to different heat radiation levels in three types of heat protective clothing

PubMed Central

HEUS, Ronald; DENHARTOG, Emiel A.

2017-01-01

To determine safe working conditions in emergency situations at petro-chemical plants in the Netherlands a study was performed on three protective clothing combinations (operator’s, firefighter’s and aluminized). The clothing was evaluated at four different heat radiation levels (3.0, 4.6, 6.3 and 10.0 k∙W∙m−2) in standing and walking posture with a thermal manikin RadMan™. Time till pain threshold (43°C) is set as a cut-off criterion for regular activities. Operator’s clothing did not fulfil requirements to serve as protective clothing for necessary activities at heat radiation levels above 1.5 k∙W∙m−2 as was stated earlier by Den Hartog and Heus1). With firefighter’s clothing it was possible to work almost three min up to 4.6 k∙W∙m−2. At higher heat radiation levels firefighter’s clothing gave insufficient protection and aluminized clothing should be used. Maximum working times in aluminized clothing at 6.3 k∙W∙m−2 was about five min. At levels of 10.0 k∙W∙m−2 (emergency conditions) emergency responders should move immediately to lower heat radiation levels. PMID:28978903

Position statement. Restructuring, work redesign, and the job and career security of registered nurses. American Nurses Association.

PubMed

1996-01-01

The American Nurses Association (ANA) is committed to safeguarding the public, protecting and advancing the careers of professional nurses, supporting individual and collective efforts by registered nurses to protect their clients and enhancing the professional development and job security of registered nurses. As the nation's health care system is restructured, ANA is actively engaged in initiatives to strengthen the economic and general welfare of registered nurses, the safety and care for the public, and, in partnership with the state nurses associations (SNAs), oppose efforts to replace registered nurses with inappropriate substitutes.

Dynamics and protection of tripartite quantum correlations in a thermal bath

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Jin-Liang, E-mail: guojinliang80@163.com; Wei, Jin-Long

2015-03-15

We study the dynamics and protection of tripartite quantum correlations in terms of genuinely tripartite concurrence, lower bound of concurrence and tripartite geometric quantum discord in a three-qubit system interacting with independent thermal bath. By comparing the dynamics of entanglement with that of quantum discord for initial GHZ state and W state, we find that W state is more robust than GHZ state, and quantum discord performs better than entanglement against the decoherence induced by the thermal bath. When the bath temperature is low, for the initial GHZ state, combining weak measurement and measurement reversal is necessary for a successfulmore » protection of quantum correlations. But for the initial W state, the protection depends solely upon the measurement reversal. In addition, the protection cannot usually be realized irrespective of the initial states as the bath temperature increases.« less

The role of microbial low-molecular-weight autoregulatory factors (alkylhydroxybenzenes) in resistance of microorganisms to radiation and heat shock

NASA Astrophysics Data System (ADS)

El-Registan, Galina I.; Mulyukin, Andrey L.; Nikolaev, Yuri A.; Stepanenko, Irina Yu.; Kozlova, Alla N.; Martirosova, Elena I.; Shanenko, Elena F.; Strakhovskaya, Marina G.; Revina, Aleksandra A.

Low-molecular-weight cell-to-cell communication factors are produced by various pro- and eukaryotes and involved in autoregulation of the growth and development of microbial cultures. As for some bacterial and yeast species, these factors were identified as isomers and homologues of alkylhydroxybenzenes (AHB). Depending on the concentration, they participate in controlling the transition to stationary phase, entering the resting state, and stress resistance of vegetative cells to gamma-irradiation, photooxidation (singlet oxygen), and heat shock. Chemical analogues of microbial AHB protected microbial cultures from stressful situations and exerted (1) the stabilizing activity toward macromolecules and (2) the ability to scavenge active oxygen species. The stabilizing effect of AHBs resulted from their complex formation with protected macromolecules due to intermolecular hydrogen bonds, hydrophobic and electrostatic interactions and was demonstrated on models of individual enzymes (trypsin). Particularly, AHBs protected the yeast from the action of (a) active oxygen species formed during gamma-irradiation (500 Gy, 1.96 Gy/s) or (b) singlet oxygen generated in cells photosensitized by chlorin e 6 (10 μg/L). It is important that microbial AHBs were not species-specific and defended cultured microbial and animal cells from the action of organic toxicants. The use of AHBs as protectants and adaptogens is discussed as well as perspectives of further investigations.

40 CFR 147.1650 - State-administered program. [Reserved

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State-administered program. [Reserved] 147.1650 Section 147.1650 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS New York...

45 CFR 1386.20 - Designated State Protection and Advocacy agency.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON DEVELOPMENTAL DISABILITIES, DEVELOPMENTAL DISABILITIES PROGRAM FORMULA GRANT PROGRAMS State System for Protection and Advocacy of the Rights of Individuals with Developmental Disabilities § 1386.20 Designated State Protection...

40 CFR 233.52 - Program reporting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Program reporting. 233.52 Section 233.52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE... cumulative impacts of the State's permit program on the integrity of the State regulated waters...

40 CFR 233.52 - Program reporting.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Program reporting. 233.52 Section 233.52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE... cumulative impacts of the State's permit program on the integrity of the State regulated waters...

40 CFR 233.50 - Review of and objection to State permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Review of and objection to State permits. 233.50 Section 233.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE PROGRAM REGULATIONS Federal Oversight § 233.50 Review of and objection to State permits. (a) The Director shall promptly transmit...

40 CFR 233.50 - Review of and objection to State permits.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Review of and objection to State permits. 233.50 Section 233.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE PROGRAM REGULATIONS Federal Oversight § 233.50 Review of and objection to State permits. (a) The Director shall promptly transmit...

40 CFR 233.50 - Review of and objection to State permits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Review of and objection to State permits. 233.50 Section 233.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE PROGRAM REGULATIONS Federal Oversight § 233.50 Review of and objection to State permits. (a) The Director shall promptly transmit...

40 CFR 233.50 - Review of and objection to State permits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Review of and objection to State permits. 233.50 Section 233.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE PROGRAM REGULATIONS Federal Oversight § 233.50 Review of and objection to State permits. (a) The Director shall promptly transmit...

40 CFR 60.1535 - What compliance schedule must I include in my State plan?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 7 2014-07-01 2014-07-01 false What compliance schedule must I include in my State plan? 60.1535 Section 60.1535 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Introduction § 60.1535 What compliance schedule must I include in my State plan? (a) Your State...

40 CFR 60.1535 - What compliance schedule must I include in my State plan?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 6 2011-07-01 2011-07-01 false What compliance schedule must I include in my State plan? 60.1535 Section 60.1535 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Introduction § 60.1535 What compliance schedule must I include in my State plan? (a) Your State...

40 CFR 60.1535 - What compliance schedule must I include in my State plan?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 7 2013-07-01 2013-07-01 false What compliance schedule must I include in my State plan? 60.1535 Section 60.1535 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Introduction § 60.1535 What compliance schedule must I include in my State plan? (a) Your State...

40 CFR 60.1535 - What compliance schedule must I include in my State plan?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 7 2012-07-01 2012-07-01 false What compliance schedule must I include in my State plan? 60.1535 Section 60.1535 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 1999 Introduction § 60.1535 What compliance schedule must I include in my State plan? (a) Your State...

War on Drugs Policing and Police Brutality.

PubMed

Cooper, Hannah L F

2015-01-01

War on Drugs policing has failed to reduce domestic street-level drug activity: the cost of drugs remains low and drugs remain widely available. In light of growing attention to police brutality in the United States, this paper explores interconnections between specific War on Drugs policing strategies and police-related violence against Black adolescents and adults in the United States. This paper reviews literature about (1) historical connections between race/ethnicity and policing in the United States; (2) the ways that the War on Drugs eroded specific legal protections originally designed to curtail police powers; and (3) the implications of these erosions for police brutality targeting Black communities. Policing and racism have been mutually constitutive in the United States. Erosions to the 4th Amendment to the Constitution and to the Posse Comitatus Act set the foundations for two War on Drugs policing strategies: stop and frisk and Special Weapons and Tactics (SWAT) teams. These strategies have created specific conditions conducive to police brutality targeting Black communities. Conclusions/Importance: War on Drugs policing strategies appear to increase police brutality targeting Black communities, even as they make little progress in reducing street-level drug activity. Several jurisdictions are retreating from the War on Drugs; this retreat should include restoring rights originally protected by the 4th Amendment and Posse Comitatus. While these legal changes occur, police chiefs should discontinue the use of SWAT teams to deal with low-level nonviolent drug offenses and should direct officers to cease engaging in stop and frisk.

Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs.

PubMed

Reelfs, Olivier; Eggleston, Ian M; Pourzand, Charareh

2010-03-01

In humans, prolonged sunlight exposure is associated with various pathological states. The continuing drive to develop improved skin protection involves not only approaches to reduce DNA damage by solar ultraviolet B (UVB) but also the development of methodologies to provide protection against ultraviolet A (UVA), the oxidising component of sunlight. Furthermore identification of specific cellular events following ultraviolet (UV) irradiation is likely to provide clues as to the mechanism of the development of resulting pathologies and therefore strategies for protection. Our discovery that UVA radiation, leads to an immediate measurable increase in 'labile' iron in human skin fibroblasts and keratinocytes provides a new insight into UVA-induced skin damage, since iron is a catalyst of biological oxidations. The main purpose of this overview is to bring together some of the new findings related to mechanisms underlying UVA-induced iron release and to discuss novel approaches based on the use of multiantioxidants and light-activated caged-iron chelators for efficient protection of skin cells against UVA-induced iron damage.

Formal Validation of Fault Management Design Solutions

NASA Technical Reports Server (NTRS)

Gibson, Corrina; Karban, Robert; Andolfato, Luigi; Day, John

2013-01-01

The work presented in this paper describes an approach used to develop SysML modeling patterns to express the behavior of fault protection, test the model's logic by performing fault injection simulations, and verify the fault protection system's logical design via model checking. A representative example, using a subset of the fault protection design for the Soil Moisture Active-Passive (SMAP) system, was modeled with SysML State Machines and JavaScript as Action Language. The SysML model captures interactions between relevant system components and system behavior abstractions (mode managers, error monitors, fault protection engine, and devices/switches). Development of a method to implement verifiable and lightweight executable fault protection models enables future missions to have access to larger fault test domains and verifiable design patterns. A tool-chain to transform the SysML model to jpf-Statechart compliant Java code and then verify the generated code via model checking was established. Conclusions and lessons learned from this work are also described, as well as potential avenues for further research and development.

Development and assessment of disinfectant efficacy test methods for regulatory purposes.

PubMed

Tomasino, Stephen F

2013-05-01

The United States Environmental Protection Agency regulates pesticidal products, including products with antimicrobial activity. Test guidelines have been established to inform manufacturers of which methodology is appropriate to support a specific efficacy claim. This paper highlights efforts designed to improve current methods and the development and assessment of new test methods. Published by Mosby, Inc.

The Youth Labor Market in the Context of Social Policy

ERIC Educational Resources Information Center

Ivanova, I. N.

2011-01-01

Many young people in Russia find it difficult to move into employment, and given the importance of a more efficient labor force for Russia's economic future, more needs to be done by the Russian government to improve the situation. Under current conditions, the state's activity in regard to solving issues of protecting the interests of young…

Predicting the intensity of recreational use of oak woodland preserves

Treesearch

Sarah E. Reed; Kimberly A. Seymour

2008-01-01

People value proximity and easy access to protected areas in urban landscapes, including state and regional parks, wildlife refuges, and open space preserves. The popularity of outdoor recreation activities such as hiking and birdwatching has more than doubled in the past 20 years, and surveys indicate that proximity to natural areas is an important factor determining...

40 CFR 122.27 - Silvicultural activities (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2014 CFR

2014-07-01

... or after removal of bark held in self-contained bodies of water (mill ponds or log ponds) or stored on land where water is applied intentionally on the logs (wet decking). (See 40 CFR part 429, subpart... PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL POLLUTANT...

40 CFR 122.27 - Silvicultural activities (applicable to State NPDES programs, see § 123.25).

Code of Federal Regulations, 2013 CFR

2013-07-01

... or after removal of bark held in self-contained bodies of water (mill ponds or log ponds) or stored on land where water is applied intentionally on the logs (wet decking). (See 40 CFR part 429, subpart... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EPA ADMINISTERED PERMIT PROGRAMS: THE NATIONAL...

50 CFR 300.203 - Identification and certification of nations engaged in bycatch of protected living marine resources.

Code of Federal Regulations, 2012 CFR

2012-10-01

... effectiveness to those of the United States, NMFS will evaluate if different conditions exist that could bear on... conditions that could bear on the feasibility and efficacy of these measures, and which, in the case of an...) Undertake, where appropriate, cooperative research activities on species assessments and improved bycatch...

10 CFR 50.13 - Attacks and destructive acts by enemies of the United States; and defense activities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Requirement of License, Exceptions § 50.13 Attacks and... construct and operate a production or utilization facility, or for an amendment to such license, is not required to provide for design features or other measures for the specific purpose of protection against...

Putrescine overproduction negatively impacts the oxidative state of poplar cells in culture

Treesearch

Sridev Mohapatra; Rakesh Minocha; Stephanie Long

2009-01-01

While polyamines (PAs) have been suggested to protect cells against Reactive Oxygen Species (ROS), their catabolism is known to generate ROS. We compared the activities of several enzymes and cellular metabolites involved in the ROS scavenging pathways in two isogenic cell lines of poplar (Populus nigra × maximowiczii) differing in their PA...

Protecting marine parks and sanctuaries from aquatic nuisance species releases from ballast during emergency response events

Treesearch

Phyllis A. Green

2011-01-01

Commercial shipping activities that release aquatic invasive species are recognized globally as a dominant transport vector for marine invasions. Aquatic nuisance species (ANS) introductions have resulted in billions of dollars of damages and immeasurable biological devastation within the Great Lakes. National Park Service managers are working with United States...

Wet feet and sappy fingers: lessons learned from restoration work in the West Virginia highlands

Treesearch

Amy Cimarolli; David W. Saville

2010-01-01

This presentation summarizes our practical experiences from a decade of working with state and federal agencies and private landowners to protect, conserve, and restore the spruce forests and fir swamps of West Virginia. We present case studies that demonstrate the collaborative planning processes, site selection techniques, and restoration activities used in our...

78 FR 26782 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; State...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

...: Administration for Community Living, HHS. ACTION: Notice. SUMMARY: The Administration for Community Living (ACL....eop.gov , Attn: OMB Desk Officer for ACL. FOR FURTHER INFORMATION CONTACT: Elena Fazio at 202-357-3583 or email: [email protected]acl.hhs.gov . SUPPLEMENTARY INFORMATION: In compliance with 44 U.S.C. 3507, ACL...

75 FR 52972 - Notice of Temporary Closures and Restrictions on Specific Uses of Public Lands in Pershing County...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

..., more or less. The closure and temporary restrictions are necessary to provide a safe environment for... or activities that are necessary to provide a safe environment for the public and for participants in... and protect the environment on public lands, as well as support state and local law enforcement...

Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties

DTIC Science & Technology

2013-03-19

vine grape production in the United States of America and Europe, while P. obscurans causes Phomopsis leaf blight and fruit rot of strawberry ... strawberry fruit rot diseases in Louisiana and Mississippi. Crop Protect. 2007, 26, 1449–1458. 25. Denny, W.A.; Cain, B.F.; Atwell, G.J.; Hansch, C

78 FR 67167 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... staff, and the State's short and long term goals for implementing the draft feed standards. The burden... Administration, 240-453-6845, [email protected] . SUPPLEMENTARY INFORMATION: In compliance with 44 U.S.C... responsible for ensuring that all food and feed moving in interstate commerce, except those under the U.S...

An update on USGS studies of the Summitville Mine and its downstream environmental effects

USGS Publications Warehouse

Plumlee, Geoffrey S.; Edelmann, Patrick R.

1995-01-01

The Summitville gold mine, located at ~3800 meters (11,500 ft) elevation in the San Juan Mountains of southwestern Colorado, was the focus of extensive public attention in 1992 and 1993 for environmental problems stemming from recent open-pit mining activities. Summitville catalyzed national debates about the environmental effects of modern mining activities, and became the focus of arguments for proposed revisions to the 1872 Mining Law governing mining activities on public lands. In early 1993, the State of Colorado, U.S. Environmental Protection Agency (EPA), U.S. Geological Survey (USGS), U.S. Fish and Wildlife Service (USFWS), Colorado State University, San Luis Valley agencies, downstream water users, private companies, and individuals began a multi-disciplinary research program to provide needed scientific information on Summitville's environmental problems and downstream environmental effects. Detailed results of this multi-agency effort were presented, along with legal and policy issues, at the Summitville Forum in January, 1995, at Colorado State University, Fort Collins, Colorado.

Land Use and Land Cover Change Dynamics across the Brazilian Amazon: Insights from Extensive Time-Series Analysis of Remote Sensing Data

PubMed Central

Carreiras, João M. B.; Jones, Joshua; Lucas, Richard M.; Gabriel, Cristina

2014-01-01

Throughout the Amazon region, the age of forests regenerating on previously deforested land is determined, in part, by the periods of active land use prior to abandonment and the frequency of reclearance of regrowth, both of which can be quantified by comparing time-series of Landsat sensor data. Using these time-series of near annual data from 1973–2011 for an area north of Manaus (in Amazonas state), from 1984–2010 for south of Santarém (Pará state) and 1984–2011 near Machadinho d’Oeste (Rondônia state), the changes in the area of primary forest, non-forest and secondary forest were documented from which the age of regenerating forests, periods of active land use and the frequency of forest reclearance were derived. At Manaus, and at the end of the time-series, over 50% of regenerating forests were older than 16 years, whilst at Santarém and Machadinho d’Oeste, 57% and 41% of forests respectively were aged 6–15 years, with the remainder being mostly younger forests. These differences were attributed to the time since deforestation commenced but also the greater frequencies of reclearance of forests at the latter two sites with short periods of use in the intervening periods. The majority of clearance for agriculture was also found outside of protected areas. The study suggested that a) the history of clearance and land use should be taken into account when protecting deforested land for the purpose of restoring both tree species diversity and biomass through natural regeneration and b) a greater proportion of the forested landscape should be placed under protection, including areas of regrowth. PMID:25099362

Land use and land cover change dynamics across the Brazilian Amazon: insights from extensive time-series analysis of remote sensing data.

PubMed

Carreiras, João M B; Jones, Joshua; Lucas, Richard M; Gabriel, Cristina

2014-01-01

Throughout the Amazon region, the age of forests regenerating on previously deforested land is determined, in part, by the periods of active land use prior to abandonment and the frequency of reclearance of regrowth, both of which can be quantified by comparing time-series of Landsat sensor data. Using these time-series of near annual data from 1973-2011 for an area north of Manaus (in Amazonas state), from 1984-2010 for south of Santarém (Pará state) and 1984-2011 near Machadinho d'Oeste (Rondônia state), the changes in the area of primary forest, non-forest and secondary forest were documented from which the age of regenerating forests, periods of active land use and the frequency of forest reclearance were derived. At Manaus, and at the end of the time-series, over 50% of regenerating forests were older than 16 years, whilst at Santarém and Machadinho d'Oeste, 57% and 41% of forests respectively were aged 6-15 years, with the remainder being mostly younger forests. These differences were attributed to the time since deforestation commenced but also the greater frequencies of reclearance of forests at the latter two sites with short periods of use in the intervening periods. The majority of clearance for agriculture was also found outside of protected areas. The study suggested that a) the history of clearance and land use should be taken into account when protecting deforested land for the purpose of restoring both tree species diversity and biomass through natural regeneration and b) a greater proportion of the forested landscape should be placed under protection, including areas of regrowth.

Redox homeostasis: The Golden Mean of healthy living

PubMed Central

Ursini, Fulvio; Maiorino, Matilde; Forman, Henry Jay

2016-01-01

The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state. The first is that redox signaling requires sudden switching on of oxidant production and bypassing of antioxidant mechanisms rather than a continuous process that, like other signaling mechanisms, can be smoothly turned up or down. The second is the misperception that reactions in redox signaling involve “reactive oxygen species” rather than reaction of specific electrophiles with specific protein thiolates. The third is that hormesis provides protection against oxidants by increasing cellular defense or repair mechanisms rather than by specifically addressing the offset of redox homeostasis. Instead, we propose that both oxidant and antioxidant signaling are main features of redox homeostasis. As the redox shift is rapidly reversed by feedback reactions, homeostasis is maintained by continuous signaling for production and elimination of electrophiles and nucleophiles. Redox homeostasis, which is the maintenance of nucleophilic tone, accounts for a healthy physiological steady state. Electrophiles and nucleophiles are not intrinsically harmful or protective, and redox homeostasis is an essential feature of both the response to challenges and subsequent feedback. While the balance between oxidants and nucleophiles is preserved in redox homeostasis, oxidative stress provokes the establishment of a new radically altered redox steady state. The popular belief that scavenging free radicals by antioxidants has a beneficial effect is wishful thinking. We propose, instead, that continuous feedback preserves nucleophilic tone and that this is supported by redox active nutritional phytochemicals. These nonessential compounds, by activating Nrf2, mimic the effect of endogenously produced electrophiles (parahormesis). In summary, while hormesis, although globally protective, results in setting up of a new phenotype, parahormesis contributes to health by favoring maintenance of homeostasis. PMID:26820564

40 CFR 256.22 - Recommendations for State regulatory powers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Recommendations for State regulatory powers. 256.22 Section 256.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.22 - Recommendations for State regulatory powers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Recommendations for State regulatory powers. 256.22 Section 256.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.21 - Requirements for State regulatory powers.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for State regulatory powers. 256.21 Section 256.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.21 - Requirements for State regulatory powers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for State regulatory powers. 256.21 Section 256.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.21 - Requirements for State regulatory powers.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for State regulatory powers. 256.21 Section 256.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.22 - Recommendations for State regulatory powers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Recommendations for State regulatory powers. 256.22 Section 256.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 272.951 - Louisiana state-administered program: Final authorization.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Louisiana state-administered program: Final authorization. 272.951 Section 272.951 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) APPROVED STATE HAZARDOUS WASTE MANAGEMENT PROGRAMS Louisiana § 272.951...

40 CFR 31.37 - Subgrants.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Subgrants. 31.37 Section 31.37 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE UNIFORM... Requirements Changes, Property, and Subawards § 31.37 Subgrants. (a) States. States shall follow State law and...

40 CFR 35.3155 - Payments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Payments. 35.3155 Section 35.3155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3155 Payments. (a) Payment schedule. The State...

40 CFR 35.3155 - Payments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Payments. 35.3155 Section 35.3155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3155 Payments. (a) Payment schedule. The State...

40 CFR 35.3155 - Payments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Payments. 35.3155 Section 35.3155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3155 Payments. (a) Payment schedule. The State...

40 CFR 35.3155 - Payments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Payments. 35.3155 Section 35.3155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3155 Payments. (a) Payment schedule. The State...

40 CFR 57.815 - State notification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 5 2010-07-01 2010-07-01 false State notification. 57.815 Section 57.815 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Technology § 57.815 State notification. The Administrator shall give notice of the final decision in writing...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 256.20 - Requirements for State legal authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for State legal authority. 256.20 Section 256.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Solid Waste...

40 CFR 35.3155 - Payments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Payments. 35.3155 Section 35.3155 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE State Water Pollution Control Revolving Funds § 35.3155 Payments. (a) Payment schedule. The State...

Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression.

PubMed

Feldmann, Jérôme; Leligdowicz, Aleksandra; Jaye, Assan; Dong, Tao; Whittle, Hilton; Rowland-Jones, Sarah L

2009-12-01

Chronic immune activation is thought to play a major role in human immunodeficiency virus (HIV) pathogenesis, but the relative contributions of multiple factors to immune activation are not known. One proposed mechanism to protect against immune activation is the ability of Nef proteins from some HIV and simian immunodeficiency virus strains to downregulate the T-cell receptor (TCR)-CD3 complex of the infected cell, thereby reducing the potential for deleterious activation. HIV type 1 (HIV-1) Nef has lost this property. In contrast to HIV-1, HIV-2 infection is characterized by a marked disparity in the disease course, with most individuals maintaining a normal life span. In this study, we examined the relationship between the ability of HIV-2 Nef proteins to downregulate the TCR and immune activation, comparing progressors and nonprogressors. Representative Nef variants were isolated from 28 HIV-2-infected individuals. We assessed their abilities to downregulate the TCR from the surfaces of CD4 T cells. In the same individuals, the activation of peripheral lymphocytes was evaluated by measurement of the expression levels of HLA-DR and CD38. We observed a striking correlation of the TCR downregulation efficiency of HIV-2 Nef variants with immune activation in individuals with a low viral load. This strongly suggests that Nef expression can influence the activation state of the immune systems of infected individuals. However, the efficiency of TCR downregulation by Nef was not reduced in progressing individuals, showing that TCR downregulation does not protect against progression in HIV-2 infection.

Protective measurement of the wave function of a single squeezed harmonic-oscillator state

NASA Astrophysics Data System (ADS)

Alter, Orly; Yamamoto, Yoshihisa

1996-05-01

A scheme for the "protective measurement"

New State Forest Practice Laws. A review of state laws and their natural resource data requirements

NASA Technical Reports Server (NTRS)

Klein, S. B.

1980-01-01

Forest practice regulations can be established by being specified in state law or by being promulgated by some other official body delegated the authority to do so. At the state level, public regulation of private forest practices resulted in many cases, in the enactment of state forest practice laws regulating both private, and in some cases, public landowner activities. These laws aim not only to protect natural environments, but also to encourage continuous productivity of forest lands, to maintain or enhance aesthetic values, and to serve as an implementing mechanism to control water pollution. Profiles of regulations in California, Idaho, Maine, Nevada, New Hampshire, Oregon, and Washington are examined and assessed. Voluntary guidelines in use in 18 states are summarized.

MO-E-213-00: What Is Medical Physics Without Radiation Safety?

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The focus of work of medical physicists in 1980’s was on quality control and quality assurance. Radiation safety was important but was dominated by occupational radiation protection. A series of over exposures of patients in radiotherapy, nuclear medicine and observation of skin injuries among patients undergoing interventional procedures in 1990’s started creating the need for focus on patient protection. It gave medical physicists new directions to develop expertise in patient dosimetry and dose management. Publications creating awareness on cancer risks from CT in early part of the current century and over exposures in CT in 2008 brought radiation risks inmore » public domain and created challenging situations for medical physicists. Increasing multiple exposures of individual patient and patient doses of few tens of mSv or exceeding 100 mSv are increasing the role of medical physicists. Expansion of usage of fluoroscopy in the hands of clinical professionals with hardly any training in radiation protection shall require further role for medical physicists. The increasing publications in journals, recent changes in Safety Standards, California law, all increase responsibilities of medical physicists in patient protection. Newer technological developments in dose efficiency and protective devices increase percentage of time devoted by medical physicists on radiation protection activities. Without radiation protection, the roles, responsibilities and day-to-day involvement of medical physicists in diagnostic radiology becomes questionable. In coming years either medical radiation protection may emerge as a specialty or medical physicists will have to keep major part of day-to-day work on radiation protection. Learning Objectives: To understand how radiation protection has been increasing its role in day-to-day activities of medical physicist To be aware about international safety Standards, national and State regulations that require higher attention to radiation protection than in past To be aware about possible emergence of medical radiation protection as a specialty and challenges for medical physicists.« less

Research and Operational Support for the Study of Militarily Relevant Infectious Diseases of Interest to the United States Army and the Royal Thai Army

DTIC Science & Technology

2008-01-01

funding support for Royal Thai Army at Armed Forces Research Institute of Medical Sciences (AFRIMS) engaged in research activities in collaboration with... Active and Passive Protection of Mice against Japanese Encephalitis Virus 55 (a) Investigators 55 (b) Objectives 55 (c) Methods 55 (d) Results...Research Project: Sentinel Surveillance for Emerging Diseases Causing Dengue-like or Acute Encephalitis Syndrome in the Philippines (SEDP) 83 (a

24 CFR 5.526 - Protection from liability for responsible entities and State and local government agencies and...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 214(e) (42 U.S.C 1436a(e)). (b) Protection from liability for State and local government agencies... responsible entities and State and local government agencies and officials. 5.526 Section 5.526 Housing and... for responsible entities and State and local government agencies and officials. (a) Protection from...

24 CFR 5.526 - Protection from liability for responsible entities and State and local government agencies and...

Code of Federal Regulations, 2011 CFR

2011-04-01

... Section 214(e) (42 U.S.C 1436a(e)). (b) Protection from liability for State and local government agencies... responsible entities and State and local government agencies and officials. 5.526 Section 5.526 Housing and... for responsible entities and State and local government agencies and officials. (a) Protection from...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 142.4 - State and local authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false State and local authority. 142.4 Section 142.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... local authority. Nothing in this part shall diminish any authority of a State or political subdivision...

40 CFR 142.4 - State and local authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State and local authority. 142.4 Section 142.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... local authority. Nothing in this part shall diminish any authority of a State or political subdivision...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 239.12 - Modifications of state programs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Modifications of state programs. 239.12 Section 239.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...'s initial application, but may have a significant impact on the adequacy of the state's permit...

40 CFR 256.62 - Requirements for public participation in State regulatory development.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements for public participation in State regulatory development. 256.62 Section 256.62 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE...

40 CFR 501.34 - Procedures for withdrawal of State programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Procedures for withdrawal of State programs. 501.34 Section 501.34 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STATE SLUDGE MANAGEMENT PROGRAM REGULATIONS Program Approval, Revision and Withdrawal § 501...

40 CFR 501.33 - Criteria for withdrawal of State programs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Criteria for withdrawal of State programs. 501.33 Section 501.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STATE SLUDGE MANAGEMENT PROGRAM REGULATIONS Program Approval, Revision and Withdrawal § 501...