Changes in Magnetic Mineralogy Through a Depth Sequence of Hydrocarbon Contaminated Sediments

NASA Astrophysics Data System (ADS)

Ameen, N. N.; Klüglein, N.; Appel, E.; Petrovsky, E.; Kappler, A.

2013-12-01

Sediments, soils and groundwater can act as a natural storage for many types of pollution. This study aims to investigate ferro(i)magnetic phase formation and transformation in the presence of organic contaminants (hydrocarbons) and its relation to bacterial activity, in particular in the zone of fluctuating water levels. The work extends previous studies conducted at the same site. The study area is a former military air base at Hradčany, Czech Republic (50°37'22.71"N, 14°45'2.24"E). Due to leaks in petroleum storage tanks and jet fuelling stations over years of active use the site was heavily contaminated with petroleum hydrocarbons, until the base was closed in 1991. This site is one of the most important sources of high quality groundwater in the Czech Republic. During remediation processes the groundwater level in the sediments fluctuated, driving the hydrocarbon contaminants to lower depth levels along with the groundwater and leading to magnetite formation (Rijal et al., Environ.Pollut., 158, 1756-1762, 2010). In our study we drilled triplicate cores at three locations which were studied earlier. Magnetic susceptibility (MS) profiles combined with other magnetic properties were analyzed to obtain the ferro(i)magnetic concentration distributions along the depth sections. Additionally the sediment properties, hydrocarbon content and bacterial activity were studied. The triplicate cores were used to statistically discriminate outliers and to recognize significant magnetic signatures with depth. The results show that the highest concentration of ferrimagnetic phases (interpreted as newly formed magnetite) exists at the probable top of the groundwater fluctuation (GWF) zone. For example at one of the sites this zone is found between 1.4-1.9 m depth (groundwater table at ~2.3 m depth). High S-ratio and the correlation of ARM with MS values confirm the contribution of magnetite for the ferro(i)magnetic enhancement in the GWF zone. In the previous studies the MS signals revealed small-scale isolated features, but with the use of triplicate cores significant trends of MS could be identified, showing an increase from the lowermost position of the groundwater table upward. Bacterial activity is likely responsible for magnetite formation in this depth range as indicated by most probable number (MPN) results of iron-reducing bacteria.

Rapid climate fluctuations over the past millennium: evidence from a lacustrine record of Basomtso Lake, southeastern Tibetan Plateau

PubMed Central

Li, Kai; Liu, Xingqi; Herzschuh, Ulrike; Wang, Yongbo

2016-01-01

Abrupt climate changes and fluctuations over short time scales are superimposed on long-term climate changes. Understanding rapid climate fluctuations at the decadal time scale over the past millennium will enhance our understanding of patterns of climate variability and aid in forecasting climate changes in the future. In this study, climate changes on the southeastern Tibetan Plateau over the past millennium were determined from a 4.82-m-long sediment core from Basomtso Lake. At the centennial time scale, the Medieval Climate Anomaly (MCA), Little Ice Age (LIA) and Current Warm Period (CWP) are distinct in the Basomtso region. Rapid climate fluctuations inferred from five episodes with higher sediment input and likely warmer conditions, as well as seven episodes with lower sediment input and likely colder conditions, were well preserved in our record. These episodes with higher and lower sediment input are characterized by abrupt climate changes and short time durations. Spectral analysis indicates that the climate variations at the centennial scale on the southeastern Tibetan Plateau are influenced by solar activity during the past millennium. PMID:27091591

Marshall N. Rosenbluth Outstanding Doctoral Thesis Award Talk: Simultaneous Measurement of Electron Temperature and Density Fluctuations in the Core of DIII-D Plasmas

NASA Astrophysics Data System (ADS)

White, A. E.

2009-11-01

Multi-field fluctuation measurements provide opportunities for rigorous comparison between experiment and nonlinear gyrokinetic turbulence simulations. A unique set of diagnostics on DIII-D allows for simultaneous study of local, long-wavelength (0 < kθρs< 0.5) electron temperature and density fluctuations in the core plasma (0.4 < ρ< 0.8). Previous experiments in L-mode indicate that normalized electron temperature fluctuation levels (40 < f < 400,kHz) increase with radius from ˜0.4% at ρ= 0.5 to ˜2% at ρ=0.8, similar to simultaneously measured density fluctuations. Electron cyclotron heating (ECH) is used to increase Te, which increases electron temperature fluctuation levels and electron heat transport in the experiments. In contrast, long wavelength density fluctuation levels change very little. The different responses are consistent with increased TEM drive relative to ITG-mode drive. A new capability at DIII-D is the measurement of phase angle between electron temperature and density fluctuations using coupled correlation electron cyclotron emission radiometer and reflectometer diagnostics. Linear and nonlinear GYRO runs have been used to design validation experiments that focus on measurements of the phase angle. GYRO shows that if Te and ∇Te increase 50% in a beam-heated L-mode plasma (ρ=0.5), then the phase angle between electron temperature and density fluctuations decreases 30%-50% and electron temperature fluctuation levels increase a factor of two more than density fluctuations. Comparisons between these predictions and experimental results will be presented.

Hydrodynamic radius fluctuations in model DNA-grafted nanoparticles

NASA Astrophysics Data System (ADS)

Vargas-Lara, Fernando; Starr, Francis W.; Douglas, Jack F.

2016-05-01

We utilize molecular dynamics simulations (MD) and the path-integration program ZENO to quantify hydrodynamic radius (Rh) fluctuations of spherical symmetric gold nanoparticles (NPs) decorated with single-stranded DNA chains (ssDNA). These results are relevant to understanding fluctuation-induced interactions among these NPs and macromolecules such as proteins. In particular, we explore the effect of varying the ssDNA-grafted NPs structural parameters, such as the chain length (L), chain persistence length (lp), NP core size (R), and the number of chains (N) attached to the nanoparticle core. We determine Rh fluctuations by calculating its standard deviation (σRh) of an ensemble of ssDNA-grafted NPs configurations generated by MD. For the parameter space explored in this manuscript, σR h shows a peak value as a function of N, the amplitude of which depends on L, lp and R, while the broadness depends on R.

Simulation of drift wave instability in field-reversed configurations using global magnetic geometry

NASA Astrophysics Data System (ADS)

Fulton, D. P.; Lau, C. K.; Lin, Z.; Tajima, T.; Holod, I.; the TAE Team

2016-10-01

Minimizing transport in the field-reversed configuration (FRC) is essential to enable FRC-based fusion reactors. Recently, significant progress on advanced beam-driven FRCs in C-2 and C-2U (at Tri Alpha Energy) provides opportunities to study transport properties using Doppler backscattering (DBS) measurements of turbulent fluctuations and kinetic particle-in-cell simulations of driftwaves in realistic equilibria via the Gyrokinetic Toroidal Code (GTC). Both measurements and simulations indicate relatively small fluctuations in the scrape-off layer (SOL). In the FRC core, local, single flux surface simulations reveal strong stabilization, while experiments indicate quiescent but finite fluctuations. One possible explanation is that turbulence may originate in the SOL and propagate at very low levels across the separatrix into the core. To test this hypothesis, a significant effort has been made to develop A New Code (ANC) based on GTC physics formulations, but using cylindrical coordinates which span the magnetic separatrix, including both core and SOL. Here, we present first results from global ANC simulations.

Orbital Noise of the Earth Causes Intensity Fluctuation in the Geomagnetic Field

NASA Technical Reports Server (NTRS)

Liu, Han-Shou; Kolenkiewicz, R.; Wade, C., Jr.

2003-01-01

Orbital noise of Earth's obliquity can provide an insight into the core of the Earth that causes intensity fluctuations in the geomagnetic field. Here we show that noise spectrum of the obliquity frequency have revealed a series of frequency periods centered at 250-, 1OO-, 50-, 41-, 30-, and 26-kyr which are almost identical with the observed spectral peaks from the composite curve of 33 records of relative paleointensity spanning the past 800 kyr (Sint-800 data). A continuous record for the past two million years also reveals the presence of the major 100 kyr periodicity in obliquity noise and geomagnetic intensity fluctuations. These results of correlation suggest that obliquity noise may power the dynamo, located in the liquid outer core of the Earth, which generates the geomagnetic field.

Study of stator-vane fluctuating pressures in a turbofan engine for static and flight tests

NASA Technical Reports Server (NTRS)

Mueller, A. W.

1984-01-01

As part of a program to study the fan noise generated from turbofan engines, fluctuating surface pressures induced by fan-rotor wakes were measured on core- and bypass-stator outlet guide vanes of a modified JT15D-1 engine. Tests were conducted with the engine operating on an outdoor test stand and in flight. The amplitudes of pressures measured at fan-rotor blade-passage fundamental frequencies were generally higher and appeared less stable for the static tests than for the flight tests. Fluctuating pressures measured at the blade-passage frequency of the high-speed core compressor were interpreted to be acoustic; however, disturbance trace velocities for either the convected rotor wakes or acoustic pressures were difficult to interpret because of the complex environment.

Torsional Oscillations of the Earths's Core

NASA Technical Reports Server (NTRS)

Hide, Raymond; Boggs, Dale H.; Dickey, Jean O.

1997-01-01

Torsional oscillations of the Earth's liquid metallic outer core are investigated by diving the core into twenty imaginary e1qui-volume annuli coaxial with the axis of ratation of the Earth and determining temproal fluctuations in the axial component of angular memonetum of each annulus under the assumption of iso-rotation on cylindrical surfaces.

Remanent magnetization stratigraphy of lunar cores

NASA Technical Reports Server (NTRS)

Banerjee, S. K.; Gingrich, D.; Marvin, J. A.

1977-01-01

Depth dependent fluctuations have been observed in the natural remanent magnetizations (NRM) of drive cores and drill strings from Apollo 16 and 17 missions. Partial demagnetization of unstable secondary magnetizations and identification of characteristic error signals from a core which is known to have been recently disturbed allow us to identify and isolate the stable NRM stratigraphy in double drive core 60010/60009 and drill strings 60002-60004. The observed magnetization fluctuations persist after normalization to take into account depth dependent variations in the carriers of stable NRM. We tentatively ascribe the stable NRM stratigraphy to instantaneous records of past magnetic fields at the lunar surface and suggest that the stable NRM stratigraphy technique could develop as a new relative time-stratigraphic tool, to be used with other physical measurements such as relative intensity of ferromagnetic resonance and charged particle track density to study the evolution of the lunar regolith.

Strong radial electric field shear and reduced fluctuations in a reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapman, B.E.; Chiang, C.S.; Prager, S.C.

1997-05-01

A strongly sheared radial electric field is observed in enhanced confinement discharges in the MST reversed-field pinch. The strong shear develops in a narrow region in the plasma edge. Electrostatic fluctuations are reduced over the entire plasma edge with an extra reduction in the shear region. Magnetic fluctuations, resonant in the plasma core but global in extent, are also reduced. The reduction of fluctuations in the shear region is presumably due to the strong shear, but the causes of the reductions outside this region have not been established.

Adapting risk management and computational intelligence network optimization techniques to improve traffic throughput and tail risk analysis.

DOT National Transportation Integrated Search

2014-04-01

Risk management techniques are used to analyze fluctuations in uncontrollable variables and keep those fluctuations from impeding : the core function of a system or business. Examples of this are making sure that volatility in copper and aluminum pri...

An accelerating high-latitude jet in Earth's core

NASA Astrophysics Data System (ADS)

Finlay, C. C.; Livermore, P. W.; Hollerbach, R.

2016-12-01

The structure of the core-generated magnetic field, and how it changes in time (its secular variation or SV), supplies an invaluable constraint on the dynamics of the outer core. At high latitude, previous studies have noted distinctive behaviour of secular change, in particular suggesting a polar vortex tied to the dynamics within the tangent cylinder region. Recent high-resolution observational models that include data from the Swarm satellites have refined the structure of observed SV, to a rapidly changing circular daisy-chain configuration centred on the north geographic pole, on or very close to the tangent cylinder itself. Motivated by theoretical considerations of the likely dynamical regime of the core, we demonstrate that this feature can be explained by a localised westwards cylindrical jet of 420 km width centred the tangent cylinder, whose amplitude appears to have increased in strength by a factor of three over the period 2000-2016 to about 40 km/yr. The current accelerating phase may be a short fragment of decadal fluctuations of the jet strength linked to both torsional wave activity and the rotation direction of the inner core.

Mood Fluctuation and Psychobiological Instability: The Same Core Functions Are Disrupted by Novel Psychoactive Substances and Established Recreational Drugs

PubMed Central

Parrott, Andrew C.

2018-01-01

Many novel psychoactive substances (NPS) have entered the recreational drug scene in recent years, yet the problems they cause are similar to those found with established drugs. This article will debate the psychobiological effects of these newer and more traditional substances. It will show how they disrupt the same core psychobiological functions, so damaging well-being in similar ways. Every psychoactive drug causes mood states to fluctuate. Users feel better on-drug, then feel worse off-drug. The strength of these mood fluctuations is closely related to their addiction potential. Cyclical changes can occur with many other core psychobiological functions, such as information processing and psychomotor speed. Hence the list of drug-related impairments can include: homeostatic imbalance, HPA axis disruption, increased stress, altered sleep patterns, neurohormonal changes, modified brain rhythms, neurocognitive impairments, and greater psychiatric vulnerability. Similar patterns of deficit are found with older drugs such as cocaine, nicotine and cannabis, and newer substances such as 3,4-methylenedioxymethamphetamine (MDMA), mephedrone and spice. All psychoactive drugs damage human well-being through similar basic neuropsychobiological mechanisms. PMID:29533974

Electrostatic and magnetic measurements of turbulence and transport in Extrap T2

NASA Astrophysics Data System (ADS)

Möller, Anders; Sallander, Eva

1999-10-01

Langmuir probe and magnetic pick-up coil measurements are used to study edge turbulence in the Extrap T2 reversed field pinch. Magnetic fluctuations resonant outside the toroidal field reversal surface are observed where previously only fluctuations in the spectra of potential and electron density and temperature have been measured. Results are presented which imply that these fluctuations are coupled to and also correlated to the internally resonant tearing mode fluctuations. Evidence of coupling between low-frequency (<100 kHz) and high-frequency fluctuations is also presented. The normalized floating potential fluctuations are seen to increase with the edge electron temperature. This causes an increase of the potential and density fluctuation driven transport with the temperature which is faster than linear. These results, in combination, are consistent with a picture where internally resonant fluctuations couple to edge fluctuations through radial heat conduction from the stochastic core to the edge.

The 13 million year Cenozoic pulse of the Earth

NASA Astrophysics Data System (ADS)

Chen, Jiasheng; Kravchinsky, Vadim A.; Liu, Xiuming

2015-12-01

The geomagnetic polarity reversal rate changes radically from very low to extremely high. Such process indicates fundamental changes in the Earth's core reorganization and core-mantle boundary heat flow fluctuations. However, we still do not know how critical such changes are to surface geology and climate processes. Our analysis of the geomagnetic reversal frequency, oxygen isotope record, and tectonic plate subduction rate, which are indicators of the changes in the heat flux at the core mantle boundary, climate and plate tectonic activity, shows that all these changes indicate similar rhythms on million years' timescale in the Cenozoic Era occurring with the common fundamental periodicity of ∼13 Myr during most of the time. The periodicity is disrupted only during the last 20 Myr. Such periodic behavior suggests that large scale climate and tectonic changes at the Earth's surface are closely connected with the million year timescale cyclical reorganization of the Earth's interior.

Neural evidence that human emotions share core affective properties.

PubMed

Wilson-Mendenhall, Christine D; Barrett, Lisa Feldman; Barsalou, Lawrence W

2013-06-01

Research on the "emotional brain" remains centered around the idea that emotions like fear, happiness, and sadness result from specialized and distinct neural circuitry. Accumulating behavioral and physiological evidence suggests, instead, that emotions are grounded in core affect--a person's fluctuating level of pleasant or unpleasant arousal. A neuroimaging study revealed that participants' subjective ratings of valence (i.e., pleasure/displeasure) and of arousal evoked by various fear, happiness, and sadness experiences correlated with neural activity in specific brain regions (orbitofrontal cortex and amygdala, respectively). We observed these correlations across diverse instances within each emotion category, as well as across instances from all three categories. Consistent with a psychological construction approach to emotion, the results suggest that neural circuitry realizes more basic processes across discrete emotions. The implicated brain regions regulate the body to deal with the world, producing the affective changes at the core of emotions and many other psychological phenomena.

Neural Evidence that Human Emotions Share Core Affective Properties

PubMed Central

Wilson-Mendenhall, Christine D.; Barrett, Lisa Feldman; Barsalou, Lawrence W.

2014-01-01

Research on the “emotional brain” remains centered around the idea that emotions like fear, happiness, and sadness result from specialized and distinct neural circuitry. Accumulating behavioral and physiological evidence suggests, instead, that emotions are grounded in core affect – a person's fluctuating level of pleasant or unpleasant arousal. A neuroimaging study revealed that participants' subjective ratings of valence (i.e., pleasure/displeasure) and of arousal evoked by various fear, happiness, and sadness experiences correlated with neural activity in specific brain regions (orbitofrontal cortex and amygdala, respectively). We observed these correlations across diverse instances within each emotion category, as well as across instances from all three categories. Consistent with a psychological construction approach to emotion, the results suggest that neural circuitry realizes more basic processes across discrete emotions. The implicated brain regions regulate the body to deal with the world, producing the affective changes at the core of emotions and many other psychological phenomena. PMID:23603916

Late Quaternary stratigraphy of the La Janda Basin (SW Spain) - first results and palaeoenvironmental significance

NASA Astrophysics Data System (ADS)

Höbig, Nicole; Santisteban, Juan; Mediavilla, Rosa; May, Simon Matthias; Klasen, Nicole; Brückner, Helmut; van't Hoff, Jasmijn; Reicherter, Klaus

2017-04-01

The La Janda basin in southern Spain is a near-shore geo-bio-archive comprising a variable Quaternary depositional history, with shallow marine, lacustrine, palustrine, and terrestrial strata. In the 1930s the lake was drained and is serving now as a huge agricultural area. The 33 m-core recovered in fall 2016 along with several shallower drill cores up to c. 15 m, reveals insights into a unique mixed terrestrial palaeo-environmental archive in Andalucia influenced by the Atlantic Ocean and hence the North Atlantic Oscillation (NAO) within the Gulf of Cádiz. The basin's evolution was influenced both by the postglacial marine transgression and by an active tectonic fault controlling most of the accommodation space by causing subsidence. Our long core was accompanied by further corings along an E-W striking transect in order to reveal also the relation of the influence of tectonic activity with sedimentary sequences. Multi-Sensor Core Logging has been completed. Results of sedimentological, geochemical and micropalaeontological analyses will be presented in the frame of the climate variations during the Late Pleistocene and the Holocene, along with a preliminary age-depth model based on radiocarbon (AMS-14C) and optical stimulated luminescence (OSL) dating techniques. Our investigations ultimately aim at providing valuable information on major Late Pleistocene to Holocene climatic and palaeo-environmental fluctuations in the southernmost part of the Iberian Peninsula.

SUPRATHERMAL SOLAR WIND ELECTRONS AND LANGMUIR TURBULENCE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Sunjung; Yoon, Peter H.; Choe, G. S.

2016-09-01

The steady-state model recently put forth for the solar wind electron velocity distribution function during quiet time conditions, was originally composed of three population electrons (core, halo, and superhalo) with the core remaining nonresonant with any plasma waves while the halo and superhalo separately maintained steady-state resonance with whistler- and Langmuir-frequency range fluctuations, respectively. However, a recent paper demonstrates that whistler-range fluctuations in fact have no significant contribution. The present paper represents a consummation of the model in that a self-consistent model of the suprathermal electron population, which encompasses both the halo and the superhalo, is constructed solely on themore » basis of the Langmuir fluctuation spectrum. Numerical solutions to steady-state particle and wave kinetic equations are obtained on the basis of an initial trial electron distribution and Langmuir wave spectrum. Such a finding offers a self-consistent explanation for the observed steady-state electron distribution in the solar wind.« less

The sedimentary organic matter from a Lake Ichkeul core (far northern Tunisia): Rock-Eval and biomarker approach

NASA Astrophysics Data System (ADS)

Affouri, Hassène; Sahraoui, Olfa

2017-05-01

The vertical distributions of bulk and molecular biomarker composition in samples from a ca. 156 cm sediment core from Lake Ichkeul were determined. Bulk analysis (Rock-Eval pyrolysis, carbonate, lipid extraction) and molecular analysis of saturated fractions were used to characterize the nature, preservation conditions and input of sedimentary organic matter (OM) to this sub-wet lake environment. The sediments are represented mainly by gray-black silty-clay facies where the carbonate (CaCO3) content varies in a range of 10-30% dry sediment. Rock-Eval pyrolysis revealed a homogeneous total organic carbon (TOC) content of ca. 1% sediment, but with down core fluctuation, indicating different anoxic conditions at different depths and material source variation. The values show three periods of relative enrichment, exceeding ca. 1%, at 146-134 cm, 82 cm and 14-0 cm depth. The low Hydrogen Index (HI) values [<119 mg hydrocarbon (HC)/g TOC)] were characteristic of continental Type III OM. The Tmax values in the range 415-420 °C were characteristic of immature OM at an early diagenetic stage. The distributions of n-alkanes (C17 to C34), isoprenoid (iso) alkanes (pristane and phytane), terpanes and steranes showed that the OM is a mixture of marine algal and bacterial source and emergent and floating higher plant origin. In addition, the distributions, as well as several biomarker ratios (n-alkanes, iso-alkanes/n-alkanes), showed that the OM is a mixture of immature and mature. Significant downcore fluctuation was observed in the molecular composition. This indicates intense microbial activity below ca. 50 cm core depth under an anoxic and brackish environment.

Experimental identification of nonlinear coupling between (intermediate, small)-scale microturbulence and an MHD mode in the core of a superconducting tokamak

NASA Astrophysics Data System (ADS)

Sun, P. J.; Li, Y. D.; Ren, Y.; Zhang, X. D.; Wu, G. J.; Xu, L. Q.; Chen, R.; Li, Q.; Zhao, H. L.; Zhang, J. Z.; Shi, T. H.; Wang, Y. M.; Lyu, B.; Hu, L. Q.; Li, J.; The EAST Team

2018-01-01

In this paper, we present clear experimental evidence of core region nonlinear coupling between (intermediate, small)-scale microturbulence and an magnetohydrodynamics (MHD) mode during the current ramp-down phase in a set of L-mode plasma discharges in the experimental advanced superconducting tokamak (EAST, Wan et al (2006 Plasma Sci. Technol. 8 253)). Density fluctuations of broadband microturbulence (k\\perpρi˜2{-}5.2 ) and the MHD mode (toroidal mode number m = -1 , poloidal mode number n = 1 ) are measured simultaneously, using a four-channel tangential CO2 laser collective scattering diagnostic in core plasmas. The nonlinear coupling between the broadband microturbulence and the MHD mode is directly demonstrated by showing a statistically significant bicoherence and modulation of turbulent density fluctuation amplitude by the MHD mode.

Radial and poloidal correlation reflectometry on Experimental Advanced Superconducting Tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qu, Hao; Zhang, Tao; Han, Xiang

2015-08-15

An X-mode polarized V band (50 GHz–75 GHz) radial and poloidal correlation reflectometry is designed and installed on Experimental Advanced Superconducting Tokamak (EAST). Two frequency synthesizers (12 GHz–19 GHz) are used as sources. Signals from the sources are up-converted to V band using active quadruplers and then coupled together for launching through one single pyramidal antenna. Two poloidally separated antennae are installed to receive the reflected waves from plasma. This reflectometry system can be used for radial and poloidal correlation measurement of the electron density fluctuation. In ohmically heated plasma, the radial correlation length is about 1.5 cm measured bymore » the system. The poloidal correlation analysis provides a means to estimate the fluctuation velocity perpendicular to the main magnetic field. In the present paper, the distance between two poloidal probing points is calculated with ray-tracing code and the propagation time is deduced from cross-phase spectrum. Fluctuation velocity perpendicular to the main magnetic field in the core of ohmically heated plasma is about from −1 km/s to −3 km/s.« less

Plasma Turbulence Imaging via Beam Emission Spectroscopy in the Core of the DIII-D Tokamak

NASA Astrophysics Data System (ADS)

McKee, George R.; Fonck, Raymond J.; Gupta, Deepak K.; Schlossberg, David J.; Shafer, Morgan W.; Boivin, Réjean L.; Solomon, Wayne

Beam Emission Spectroscopy (BES), a high-sensitivity, good spatial resolution imaging diagnostic system, has been deployed and recently upgraded and expanded at the DIII-D tokamak to better understand density fluctuations arising from plasma turbulence. The currently deployed system images density fluctuations over an approximately 5 × 7 cm region at the plasma mid-plane (radially scannable over 0.2 < r/a ≤ 1) with a 5 × 6 (radial × poloidal) grid of rectangular detection channels, with one microsecond time resolution. BES observes collisionally-induced, Doppler-shifted Dα fluorescence (λ = 652-655 nm) of injected deuterium neutral beam atoms. The diagnostic wavenumber sensitivity is approximately k⊥ < 2.5 cm-1, allowing measurement of longwavelength (k⊥ρI < 1) density fluctuations. The recent upgrade includes expanded fiber optics bundles, customdesigned high-transmission, sharp-edge interference filters, ultra fast collection optics, and enlarged photodiode detectors that together provide nearly an order of magnitude increase in sensitivity relative to an earlier generation BES system. The high sensitivity allows visualization of turbulence at normalized density fluctuation amplitudes of ‾n/n < 1%, typical of fluctuation levels in the core region. The imaging array allows for sampling over 2-3 turbulent eddy scale lengths, which captures the essential dynamics of eddy evolution, interaction and shearing.

Measurement of Correlation Between Flow Density, Velocity, and Density*velocity(sup 2) with Far Field Noise in High Speed Jets

NASA Technical Reports Server (NTRS)

Panda, Jayanta; Seasholtz, Richard G.; Elam, Kristie A.

2002-01-01

To locate noise sources in high-speed jets, the sound pressure fluctuations p', measured at far field locations, were correlated with each of radial velocity v, density rho, and phov(exp 2) fluctuations measured from various points in jet plumes. The experiments follow the cause-and-effect method of sound source identification, where correlation is related to the first, and correlation to the second source terms of Lighthill's equation. Three fully expanded, unheated plumes of Mach number 0.95, 1.4 and 1.8 were studied for this purpose. The velocity and density fluctuations were measured simultaneously using a recently developed, non-intrusive, point measurement technique based on molecular Rayleigh scattering. It was observed that along the jet centerline the density fluctuation spectra S(sub rho) have different shapes than the radial velocity spectra S(sub v), while data obtained from the peripheral shear layer show similarity between the two spectra. Density fluctuations in the jet showed significantly higher correlation, than either rhov(sub 2) or v fluctuations. It is found that a single point correlation from the peak sound emitting region at the end of the potential core can account for nearly 10% of all noise at 30 to the jet axis. The correlation, representing the effectiveness of a longitudinal quadrupole in generating noise 90 to the jet axis, is found to be zero within experimental uncertainty. In contrast rhov(exp 2) fluctuations were better correlated with sound pressure fluctuation at the 30 location. The strongest source of sound is found to lie at the centerline and beyond the end of potential core.

Quantifying variability in fast and slow solar wind: From turbulence to extremes

NASA Astrophysics Data System (ADS)

Tindale, E.; Chapman, S. C.; Moloney, N.; Watkins, N. W.

2017-12-01

Fast and slow solar wind exhibit variability across a wide range of spatiotemporal scales, with evolving turbulence producing fluctuations on sub-hour timescales and the irregular solar cycle modulating the system over many years. Here, we apply the data quantile-quantile (DQQ) method [Tindale and Chapman 2016, 2017] to over 20 years of Wind data, to study the time evolution of the statistical distribution of plasma parameters in fast and slow solar wind. This model-independent method allows us to simultaneously explore the evolution of fluctuations across all scales. We find a two-part functional form for the statistical distributions of the interplanetary magnetic field (IMF) magnitude and its components, with each region of the distribution evolving separately over the solar cycle. Up to a value of 8nT, turbulent fluctuations dominate the distribution of the IMF, generating the approximately lognormal shape found by Burlaga [2001]. The mean of this core-turbulence region tracks solar cycle activity, while its variance remains constant, independent of the fast or slow state of the solar wind. However, when we test the lognormality of this core-turbulence component over time, we find the model provides a poor description of the data at solar maximum, where sharp peaks in the distribution dominate over the lognormal shape. At IMF values higher than 8nT, we find a separate, extremal distribution component, whose moments are sensitive to solar cycle phase, the peak activity of the cycle and the solar wind state. We further investigate these `extremal' values using burst analysis, where a burst is defined as a continuous period of exceedance over a predefined threshold. This form of extreme value statistics allows us to study the stochastic process underlying the time series, potentially supporting a probabilistic forecast of high-energy events. Tindale, E., and S.C. Chapman (2016), Geophys. Res. Lett., 43(11) Tindale, E., and S.C. Chapman (2017), submitted Burlaga, L.F. (2001), J. Geophys. Res., 106(A8)

Dislocation Structure and Mobility in hcp He 4

DOE PAGES

Landinez Borda, Edgar Josue; Cai, Wei; de Koning, Maurice

2016-07-20

We assess the core structure and mobility of the screw and edge basal-plane dislocations in hcp 4He using path-integral Monte Carlo simulations. Our findings provide key insights into recent interpretations of giant plasticity and mass flow junction experiments. First, both dislocations are dissociated into nonsuperfluid Shockley partial dislocations separated by ribbons of stacking fault, suggesting that they are unlikely to act as one-dimensional channels that may display Lüttinger-liquid-like behavior. Second, the centroid positions of the partial cores are found to fluctuate substantially, even in the absence of applied shear stresses. This implies that the lattice resistance to motion of themore » partial dislocations is negligible, consistent with the recent experimental observations of giant plasticity. Our results indicate that both the structure of the partial cores and the zero-point fluctuations play a role in this extreme mobility.« less

The Impact of Global Warming on the Carbon Cycle of Arctic Permafrost: An Experimental and Field Based Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Onstott, Tullis C; Pffifner, Susan M; Chourey, Karuna

2014-11-07

Our results to date indicate that CO2 and CH4 fluxes from organic poor, Arctic cryosols on Axel Heiberg Island are net CH4 sinks and CO2 emitters in contrast to organic-rich peat deposits at sub-Arctic latitudes. This is based upon field observations and a 1.5 year long thawing experiment performed upon one meter long intact cores. The results of the core thawing experiments are in good agreement with field measurements. Metagenomic, metatranscriptomic and metaproteomic analyses indicate that high affinity aerobic methanotrophs belong to the uncultivated USCalpha are present in <1% abundance in these cryosols are are active in the field duringmore » the summer and in the core thawing experiments. The methanotrophs are 100 times more abundant than the methanogens. As a result mineral cryosols, which comprise 87% of Arctic tundra, are net methane sinks. Their presence and activity may account for the discrepancies observed between the atmospheric methane concentrations observed in the Arctic predicted by climate models and the observed seasonal fluctuations and decadal trends. This has not been done yet.« less

Lithology and chronology of ice-sheet fluctuations (magnetic susceptibility of cores from the western Ross Sea)

NASA Technical Reports Server (NTRS)

Jennings, Anne E.

1993-01-01

The goals of the marine geology part of WAIS include reconstructing the chronology and areal extent of ice-sheet fluctuations and understanding the climatic and oceanographic influences on ice-sheet history. As an initial step toward attaining these goals, down-core volume magnetic susceptibility (MS) logs of piston cores from three N-S transects in the western Ross Sea are compared. The core transects are within separate petrographic provinces based on analyses of till composition. The provinces are thought to reflect the previous locations of ice streams on the shelf during the last glaciation. Magnetic susceptibility is a function of magnetic mineral composition, sediment texture, and sediment density. It is applied in the western Ross Sea for two purposes: (1) to determine whether MS data differentiates the three transects (i.e., flow lines), and thus can be used to make paleodrainage reconstructions of the late Wisconsinan ice sheet; and (2) to determine whether the MS data can aid in distinguishing basal till diamictons from diamictons of glacial-marine origin and thus, aid paleoenvironmental interpretations. A comparison of the combined data of cores in each transect is presented.

Advanced Na-NiCl2 Battery Using Nickel-Coated Graphite with Core-Shell Microarchitecture.

PubMed

Chang, Hee-Jung; Canfield, Nathan L; Jung, Keeyoung; Sprenkle, Vincent L; Li, Guosheng

2017-04-05

Stationary electric energy storage devices (rechargeable batteries) have gained increasing prominence due to great market needs, such as smoothing the fluctuation of renewable energy resources and supporting the reliability of the electric grid. With regard to raw materials availability, sodium-based batteries are better positioned than lithium batteries due to the abundant resource of sodium in Earth's crust. However, the sodium-nickel chloride (Na-NiCl 2 ) battery, one of the most attractive stationary battery technologies, is hindered from further market penetration by its high material cost (Ni cost) and fast material degradation at its high operating temperature. Here, we demonstrate the design of a core-shell microarchitecture, nickel-coated graphite, with a graphite core to maintain electrochemically active surface area and structural integrity of the electron percolation pathway while using 40% less Ni than conventional Na-NiCl 2 batteries. An initial energy density of 133 Wh/kg (at ∼C/4) and energy efficiency of 94% are achieved at an intermediate temperature of 190 °C.

Quantum-Fluctuation-Initiated Coherence in Multioctave Raman Optical Frequency Combs

NASA Astrophysics Data System (ADS)

Wang, Y. Y.; Wu, Chunbai; Couny, F.; Raymer, M. G.; Benabid, F.

2010-09-01

We show experimentally and theoretically that the spectral components of a multioctave frequency comb spontaneously created by stimulated Raman scattering in a hydrogen-filled hollow-core photonic crystal fiber exhibit strong self-coherence and mutual coherence within each 12 ns driving laser pulse. This coherence arises in spite of the field’s initiation being from quantum zero-point fluctuations, which causes each spectral component to show large phase and energy fluctuations. This points to the possibility of an optical frequency comb with nonclassical correlations between all comb lines.

Investigation of the MTC noise estimation with a coupled neutronic/thermal-hydraulic dedicated model - 'Closing the loop'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Demaziere, C.; Larsson, V.

2012-07-01

This paper investigates the reliability of different noise estimators aimed at determining the Moderator Temperature Coefficient (MTC) of reactivity in Pressurized Water Reactors. By monitoring the inherent fluctuations in the neutron flux and moderator temperature, an on-line monitoring of the MTC without perturbing reactor operation is possible. In order to get an accurate estimation of the MTC by noise analysis, the point-kinetic component of the neutron noise and the core-averaged moderator temperature noise have to be used. Because of the scarcity of the in-core instrumentation, the determination of these quantities is difficult, and several possibilities thus exist for estimating themore » MTC by noise analysis. Furthermore, the effect of feedback has to be negligible at the frequency chosen for estimating the MTC in order to get a proper determination of the MTC. By using an integrated neutronic/thermal- hydraulic model specifically developed for estimating the three-dimensional distributions of the fluctuations in neutron flux, moderator properties, and fuel temperature, different approaches for estimating the MTC by noise analysis can be tested individually. It is demonstrated that a reliable MTC estimation can only be provided if the core is equipped with a sufficient number of both neutron detectors and temperature sensors, i.e. if the core contain in-core detectors monitoring both the axial and radial distributions of the fluctuations in neutron flux and moderator temperature. It is further proven that the effect of feedback is negligible for frequencies higher than 0.1 Hz, and thus the MTC noise estimations have to be performed at higher frequencies. (authors)« less

Human Topoisomerase I C-Terminal Domain Fragment Containing the Active Site Tyrosine is a Molten Globule: Implication for the Formation of Competent Productive Complex

PubMed Central

Punchihewa, Chandanamali; Dai, Jixun; Carver, Megan; Yang, Danzhou

2007-01-01

Human topoisomerase I (topo I) is an essential cellular enzyme that relaxes DNA supercoiling. The 6.3 kDa C-terminal domain of topo I contains the active site tyrosine (Tyr723) but lacks enzymatic activity by itself. Activity can be fully reconstituted when the C-terminal is associated with the 56 kDa core domain. Even though several crystal structures of topo I/DNA complexes are available, crystal structures of the free topo I protein or its individual domain fragments have been difficult to obtain. In this report we analyze the human topo I C-terminal domain structure using a variety of biophysical methods. Our results indicate that this fragment protein (topo6.3) appears to be in a molten globule state. It appears to have a native-like tertiary fold that contains a large population of α-helix secondary structure and extensive surface hydrophobic regions. Topo6.3 is known to be readily activated with the association of the topo I core domain, and the molten globule state of topo6.3 is likely to be an energy-favorable conformation for the free topo I C-terminal domain protein. The structural fluctuation and plasticity may represent an efficient mechanism in the topo I functional pathway, where the flexibility aids in the complementary association with the core domain and in the formation of a fully productive topo I complex. PMID:17434318

Magnetic properties changes due to hydrocarbon contaminated groundwater table fluctuations

NASA Astrophysics Data System (ADS)

Ameen, Nawrass

2013-04-01

This study aims to understand the mechanisms and conditions which control the formation and transformation of ferro(i)magnetic minerals caused by hydrocarbon contaminated groundwater, in particular in the zone of fluctuating water levels. The work extends previous studies conducted at the same site. The study area is a former military air base at Hradčany, Czech Republic (50°37'22.71"N, 14°45'2.24"E). The site was heavily contaminated with petroleum hydrocarbons, due to leaks in petroleum storage tanks and jet fuelling stations over years of active use by the Soviet Union, which closed the base in 1991. The site is one of the most important sources of high quality groundwater in the Czech Republic. In a previous study, Rijal et al. (2010) concluded that the contaminants could be flushed into the sediments as the water level rose due to remediation processes leading to new formation of magnetite. In this previous study three different locations were investigated; however, from each location only one core was obtained. In order to recognize significant magnetic signatures versus depth three cores from each of these three locations were drilled in early 2012, penetrating the unsaturated zone, the groundwater fluctuation (GWF) zone and extending to about one meter below the groundwater level (~2.3 m depth at the time of sampling). Magnetic susceptibility (MS) profiles combined with other magnetic properties were analyzed to obtain a significant depth distribution of the ferro(i)magnetic concentration. Sediment properties, hydrocarbon content and bacterial activity were additionally studied. The results show that the highest ferrimagnetic mineral concentrations exist between 1.4-1.9 m depth from the baseline which is interpreted as the top of the GWF zone. Spikes of MS detected in the previous studies turned out to represent small-scale isolated features, but the trend of increasing MS values from the lowermost position of the groundwater table upward was verified. Mineral magnetic parameters indicate that magnetite is responsible for the MS signal which confirms the previous results (Rijal et al., 2010). The so far existing uncertainty of the groundwater level position could be solved. Bacterial activity is studied at particular depth horizons as it is assumed to be responsible for iron mineralogy changes. References: Rijal M.L., Appel E., Petrovský E. and Blaha U., 2010. Change of magnetic properties due to fluctuations of hydrocarbon contaminated groundwater in unconsolidated sediments. Environ.Pollut., 158, 1756-1762.

Daily Rhythmic Behaviors and Thermoregulatory Patterns Are Disrupted in Adult Female MeCP2-Deficient Mice

PubMed Central

Wu, Chiping; Bardakjian, Berj L.; Zhang, Liang; Eubanks, James H.

2012-01-01

Mutations in the X-linked gene encoding Methyl-CpG-binding protein 2 (MECP2) have been associated with neurodevelopmental and neuropsychiatric disorders including Rett Syndrome, X-linked mental retardation syndrome, severe neonatal encephalopathy, and Angelman syndrome. Although alterations in the performance of MeCP2-deficient mice in specific behavioral tasks have been documented, it remains unclear whether or not MeCP2 dysfunction affects patterns of periodic behavioral and electroencephalographic (EEG) activity. The aim of the current study was therefore to determine whether a deficiency in MeCP2 is sufficient to alter the normal daily rhythmic patterns of core body temperature, gross motor activity and cortical delta power. To address this, we monitored individual wild-type and MeCP2-deficient mice in their home cage environment via telemetric recording over 24 hour cycles. Our results show that the normal daily rhythmic behavioral patterning of cortical delta wave activity, core body temperature and mobility are disrupted in one-year old female MeCP2-deficient mice. Moreover, female MeCP2-deficient mice display diminished overall motor activity, lower average core body temperature, and significantly greater body temperature fluctuation than wild-type mice in their home-cage environment. Finally, we show that the epileptiform discharge activity in female MeCP2-deficient mice is more predominant during times of behavioral activity compared to inactivity. Collectively, these results indicate that MeCP2 deficiency is sufficient to disrupt the normal patterning of daily biological rhythmic activities. PMID:22523589

The Lateglacial and Holocene history of annually laminated Lake Tiefer See

NASA Astrophysics Data System (ADS)

Theuerkauf, Martin; Dräger, Nadine; Lampe, Reinhard; Lorenz, Sebastian; Kienel, Ulrike; Schult, Manuela; Słowiński, Michał; Wulf, Sabine; Zawiska, Izabela; Brauer, Achim

2015-04-01

Lake Tiefer See (N 53.59, E 12.53) is one of the rare lakes with a long sequence of annually laminated Holocene sediments in northern Central Europe. The lake is a valuable link between laminated lakes in more oceanic climates of the Eifel region and NW Germany and laminated lakes in the more continental climate of Poland. It thus provides great potential to study past climate, vegetation and human land use along that climate transition. The sediments of Lake Tiefer See show repeated changes in varve quality and composition. To disentangle in how far these changes relate to either past climate change, lake water level fluctuations or to changes in the local environment caused by e.g. human activity, we studied 16 sediment cores taken mainly from the lake margin. Almost all cores show interruptions in sedimentation namely during the mid-Holocene, suggesting that the lake water level has been lowered during this period. However, peat-gyttia alternations point at lake level fluctuations also during the early and late Holocene. Discontinuous sedimentation in cores from intermediate depth points at recurring slumping events. The pollen record additionally indicates prominent alternations in land use intensity throughout the late Holocene. By testing correlation between the hydrological changes, changes in land use intensity and changes in the sediment record we discuss effects of climate change and further factors on varve formation in Lake Tiefer See. This study is a contribution to the Virtual Institute of Integrated Climate and Landscape Evolution Analysis -ICLEA- of the Helmholtz Association; grant number VH-VI-415.

Random phase approximation and cluster mean field studies of hard core Bose Hubbard model

NASA Astrophysics Data System (ADS)

Alavani, Bhargav K.; Gaude, Pallavi P.; Pai, Ramesh V.

2018-04-01

We investigate zero temperature and finite temperature properties of the Bose Hubbard Model in the hard core limit using Random Phase Approximation (RPA) and Cluster Mean Field Theory (CMFT). We show that our RPA calculations are able to capture quantum and thermal fluctuations significantly better than CMFT.

Brownian Motion with Active Fluctuations

NASA Astrophysics Data System (ADS)

Romanczuk, Pawel; Schimansky-Geier, Lutz

2011-06-01

We study the effect of different types of fluctuation on the motion of self-propelled particles in two spatial dimensions. We distinguish between passive and active fluctuations. Passive fluctuations (e.g., thermal fluctuations) are independent of the orientation of the particle. In contrast, active ones point parallel or perpendicular to the time dependent orientation of the particle. We derive analytical expressions for the speed and velocity probability density for a generic model of active Brownian particles, which yields an increased probability of low speeds in the presence of active fluctuations in comparison to the case of purely passive fluctuations. As a consequence, we predict sharply peaked Cartesian velocity probability densities at the origin. Finally, we show that such a behavior may also occur in non-Gaussian active fluctuations and discuss briefly correlations of the fluctuating stochastic forces.

High-stability 48-core bendable and movable optical cable for FAST telescope optical transmission system

NASA Astrophysics Data System (ADS)

Liu, Hongfei; Pan, Gaofeng; Lin, Zhong; Liu, Cheng; Zhu, Wenbai; Nan, Rendong; Li, Chunsheng; Gao, Guanjun; Luo, Wenyong; Jin, Chengjin; Song, Jinyou

2017-11-01

The construction of FAST telescope was completed in Guizhou province of China in September 2016, and a kind of novel high-stability 48-core bendable and movable optical cable was developed and applied in analog data optical transmission system of FAST. Novel structure and selective material of this optical cable ensure high stability of optical power in the process of cables round-trip motion when telescope is tracking a radio source. The 105 times bend and stretch accelerated experiment for this optical cable was implemented, and real-time optical and RF signal power fluctuation were measured. The physical structure of optical cables after 105 times round-trip motion is in good condition; the real-time optical power attenuation fluctuation is smaller than 0.044 dB; the real-time RF power fluctuation is smaller than 0.12 dB. The optical cable developed in this letter meets the requirement of FAST and has been applied in FAST telescope.

The Extent of Genome Flux and Its Role in the Differentiation of Bacterial Lineages

PubMed Central

Nowell, Reuben W.; Green, Sarah; Laue, Bridget E.; Sharp, Paul M.

2014-01-01

Horizontal gene transfer (HGT) and gene loss are key processes in bacterial evolution. However, the role of gene gain and loss in the emergence and maintenance of ecologically differentiated bacterial populations remains an open question. Here, we use whole-genome sequence data to quantify gene gain and loss for 27 lineages of the plant-associated bacterium Pseudomonas syringae. We apply an extensive error-control procedure that accounts for errors in draft genome data and greatly improves the accuracy of patterns of gene occurrence among these genomes. We demonstrate a history of extensive genome fluctuation for this species and show that individual lineages could have acquired thousands of genes in the same period in which a 1% amino acid divergence accrues in the core genome. Elucidating the dynamics of genome fluctuation reveals the rapid turnover of gained genes, such that the majority of recently gained genes are quickly lost. Despite high observed rates of fluctuation, a phylogeny inferred from patterns of gene occurrence is similar to a phylogeny based on amino acid replacements within the core genome. Furthermore, the core genome phylogeny suggests that P. syringae should be considered a number of distinct species, with levels of divergence at least equivalent to those between recognized bacterial species. Gained genes are transferred from a variety of sources, reflecting the depth and diversity of the potential gene pool available via HGT. Overall, our results provide further insights into the evolutionary dynamics of genome fluctuation and implicate HGT as a major factor contributing to the diversification of P. syringae lineages. PMID:24923323

How scaling fluctuation analyses can transform our view of the climate

NASA Astrophysics Data System (ADS)

Lovejoy, Shaun; Schertzer, Daniel

2013-04-01

There exist a bewildering diversity of proxy climate data including tree rings, ice cores, lake varves, boreholes, ice cores, pollen, foraminifera, corals and speleothems. Their quantitative use raises numerous questions of interpretation and calibration. Even in classical cases - such as the isotope signal in ice cores - the usual assumption of linear dependence on ambient temperature is only a first approximation. In other cases - such as speleothems - the isotope signals arise from multiple causes (which are not always understood) and this hinders their widespread use. We argue that traditional interpretations and calibrations - based on essentially deterministic comparisons between instrumental data, model outputs and proxies (albeit with the help of uncertainty analyses) - have been both overly ambitious while simultaneously underexploiting the data. The former since comparisons typically involve series at different temporal resolutions and from different geographical locations - one does not expect agreement in a deterministic sense, while with respect to climate models, one only expects statistical correspondences. The proxies are underexploited since comparisons are done at unique temporal and / or spatial resolutions whereas the fluctuations they describe provide information over wide ranges of scale. A convenient method of overcoming these difficulties is the use of fluctuation analysis systematically applied over the full range of available scales to determine the scaling proeprties. The new transformative element presented here, is to define fluctuations ΔT in a series T(t) at scale Δt not by differences (ΔT(Δt) = T(t+Δt) - T(t)) but rather by the difference in the means over the first and second halves of the lag Δt . This seemingly minor change - technically from "poor man's" to "Haar" wavelets - turns out to make a huge difference since for example, it is adequate for analysing temperatures from seconds to hundreds of millions of years yet remaining simple to interpret [Lovejoy and Schertzer, 2012]. It has lead for example to the discovery of the new "macroweather" regime between weather (Δt <≈ 10days) and climate (Δt ≈> 30 yrs) in which fluctuations decrease rather than increase with scale [Lovejoy, 2013]. We illustrate the transformative power of combining such fluctuation analysis with scaling by giving numerous examples from instrumental data, multiproxies, ice core proxies, corals, speleothems and GCM outputs [Lovejoy and Schertzer, 2013]. References: Lovejoy, S. (2013), What is climate?, EOS, 94, (1), 1 January, p1-2. Lovejoy, S., and D. Schertzer (2012), Haar wavelets, fluctuations and structure functions: convenient choices for geophysics, Nonlinear Proc. Geophys. , 19, 1-14 doi: 10.5194/npg-19-1-2012. Lovejoy, S., and D. Schertzer (2013), The Weather and Climate: Emergent Laws and Multifractal Cascades, 480 pp., Cambridge University Press, Cambridge.

Lake and Bog Sediment Records of Holocene Climate and Glacier Variability in the Cordillera Vilcabamba of Southern Peru

NASA Astrophysics Data System (ADS)

Schweinsberg, A.; Licciardi, J. M.; Rodbell, D. T.; Stansell, N.

2013-12-01

Records of past fluctuations in climatically sensitive tropical glaciers are among the best indicators of regional paleoclimatic trends and forcings. However, continuous sediment records in this region remain limited, particularly during the Holocene. Here we present the first continuous records of glacier activity in the Cordillera Vilcabamba (13°20'S) of southern Peru from lake and bog sediment cores in stratigraphic contact with 10Be-dated moraines. Completed analyses include sediment lithostratigraphy, magnetic susceptibility, and biogenic silica, in conjunction with AMS radiocarbon dates on charcoal. Carbon measurements, bulk density, and bulk sedimentation rates are used to derive a record of clastic sediment flux that serves as a proxy indicator of former glacier activity. Visually distinct sedimentological variations, magnetic susceptibility peaks, and radiocarbon dates were correlated among adjacent cores to construct one composite record representative of each coring site. Three composite cores are presented: two from the Rio Blanco valley and one from the Yanama valley. Sediment records from these two glaciated valleys suggest a series of environmental changes during the last ~12,000 calendar years BP. Clastic sediment flux trends are broadly consistent with published evidence that the early to middle Holocene was relatively warm and arid in the southern Peruvian Andes. An episode of high clastic flux in the late Holocene may reflect enhanced glacial activity in response to the onset of cooler and wetter conditions. A prominent peak in magnetic susceptibility at 1660 cal yr BP is present in all composite cores and serves as a chronostratigraphic marker. In addition, our new basal radiocarbon ages place limits on the cosmogenic 10Be production rate in the high Andes, suggesting the cosmogenic 10Be production rate is considerably lower than previously published estimates.

[Concentrations and Distribution of Metals in the Core Sediments from Estuary and City Section of Liaohe River].

PubMed

Wang, Wei-jie; Zhou, Jun-li; Pei, Shu-wei; Liu, Zheng-tao

2016-01-15

The particle size, total organic carbon (TOC), total nitrogen (TN), C/N ratio and metal concentrations as well as activities of 210Pb were determined in Liaohe River estuary area (LN-2) and Shenyang area (LN-5), and the organic matter resources were discussed in two core sediments. Also the index of geoaccumulation (Igeo) and enrichment factors (EFs) methods were applied to evaluate the state of heavy metal contamination in the studied sties. The study showed that both sediment cores LN-2 and LN-5 were dominated by silts, and the vertical variations of grain-size composition and organic matter were well distributed in LN- 2 while fluctuated in LN-5. According to the organic matter source analysis through C/N ratio, C/N ratio varied in the scale of 5. 24-7.93 in LN-2 which was dominated by river source, and 9.94-14.21 in LN-5 which was dominated by terrestrial input. Al, Ca, Fe, Mn, Ni, Cu, Zn, Cd, Pb and Cr in two sediment cores had different vertical changing rules, Ni and Zn in LN-2 as well as Pb and Zn in LN-5 were affected by both natural and human factors, other elements had similar distributions to those of organic matters, which showed that these elements were mainly affected by the natural activities. Based on Igeo and EFs, both sediment cores were more severely polluted with Ni, Zn and Pb than other metals. The effects of human activities on the environment were also discussed in this study, combined with the economical development of Liaoning Province and the studied sites in the past 20 years.

Density Fluctuation in Asymmetric Nozzle Plumes and Correlation with Far Field Noise

NASA Technical Reports Server (NTRS)

Panda, J.; Zaman, K. B. M. Q.

2001-01-01

A comparative experimental study of air density fluctuations in the unheated plumes of a circular, 4-tabbed-circular, chevron-circular and 10-lobed rectangular nozzles was performed at a fixed Mach number of 0.95 using a recently developed Rayleigh scattering based technique. Subsequently, the flow density fluctuations are cross-correlated with the far field sound pressure fluctuations to determine sources for acoustics emission. The nearly identical noise spectra from the baseline circular and the chevron nozzles are found to be in agreement with the similarity in spreading, turbulence fluctuations, and flow-sound correlations measured in the plumes. The lobed nozzle produced the least low frequency noise, in agreement with the weakest overall density fluctuations and flow-sound correlation. The tabbed nozzle took an intermediate position in the hierarchy of noise generation, intensity of turbulent fluctuation and flow-sound correlation. Some of the features in the 4-tabbed nozzle are found to be explainable in terms of splitting of the jet in a central large core and 4 side jetlets.

Langmuir probe measurements in a time-fluctuating-highly ionized non-equilibrium cutting arc: analysis of the electron retarding part of the time-averaged current-voltage characteristic of the probe.

PubMed

Prevosto, L; Kelly, H; Mancinelli, B

2013-12-01

This work describes the application of Langmuir probe diagnostics to the measurement of the electron temperature in a time-fluctuating-highly ionized, non-equilibrium cutting arc. The electron retarding part of the time-averaged current-voltage characteristic of the probe was analysed, assuming that the standard exponential expression describing the electron current to the probe in collision-free plasmas can be applied under the investigated conditions. A procedure is described which allows the determination of the errors introduced in time-averaged probe data due to small-amplitude plasma fluctuations. It was found that the experimental points can be gathered into two well defined groups allowing defining two quite different averaged electron temperature values. In the low-current region the averaged characteristic was not significantly disturbed by the fluctuations and can reliably be used to obtain the actual value of the averaged electron temperature. In particular, an averaged electron temperature of 0.98 ± 0.07 eV (= 11400 ± 800 K) was found for the central core of the arc (30 A) at 3.5 mm downstream from the nozzle exit. This average included not only a time-average over the time fluctuations but also a spatial-average along the probe collecting length. The fitting of the high-current region of the characteristic using such electron temperature value together with the corrections given by the fluctuation analysis showed a relevant departure of local thermal equilibrium in the arc core.

A correlation electron cyclotron emission diagnostic and the importance of multifield fluctuation measurements for testing nonlinear gyrokinetic turbulence simulations.

PubMed

White, A E; Schmitz, L; Peebles, W A; Carter, T A; Rhodes, T L; Doyle, E J; Gourdain, P A; Hillesheim, J C; Wang, G; Holland, C; Tynan, G R; Austin, M E; McKee, G R; Shafer, M W; Burrell, K H; Candy, J; DeBoo, J C; Prater, R; Staebler, G M; Waltz, R E; Makowski, M A

2008-10-01

A correlation electron cyclotron emission (CECE) diagnostic has been used to measure local, turbulent fluctuations of the electron temperature in the core of DIII-D plasmas. This paper describes the hardware and testing of the CECE diagnostic and highlights the importance of measurements of multifield fluctuation profiles for the testing and validation of nonlinear gyrokinetic codes. The process of testing and validating such codes is critical for extrapolation to next-step fusion devices. For the first time, the radial profiles of electron temperature and density fluctuations are compared to nonlinear gyrokinetic simulations. The CECE diagnostic at DIII-D uses correlation radiometry to measure the rms amplitude and spectrum of the electron temperature fluctuations. Gaussian optics are used to produce a poloidal spot size with w(o) approximately 1.75 cm in the plasma. The intermediate frequency filters and the natural linewidth of the EC emission determine the radial resolution of the CECE diagnostic, which can be less than 1 cm. Wavenumbers resolved by the CECE diagnostic are k(theta) < or = 1.8 cm(-1) and k(r) < or = 4 cm(-1), relevant for studies of long-wavelength turbulence associated with the trapped electron mode and the ion temperature gradient mode. In neutral beam heated L-mode plasmas, core electron temperature fluctuations in the region 0.5 < r/a < 0.9, increase with radius from approximately 0.5% to approximately 2%, similar to density fluctuations that are measured simultaneously with beam emission spectroscopy. After incorporating "synthetic diagnostics" to effectively filter the code output, the simulations reproduce the characteristics of the turbulence and transport at one radial location r/a = 0.5, but not at a second location, r/a = 0.75. These results illustrate that measurements of the profiles of multiple fluctuating fields can provide a significant constraint on the turbulence models employed by the code.

Changes in particle transport as a result of resonant magnetic perturbations in DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mordijck, S.; Doyle, E. J.; Rhodes, T. L.

2012-05-15

In this paper, we introduce the first direct perturbed particle transport measurements in resonant magnetic perturbation (RMP) H-mode plasmas. The perturbed particle transport increases as a result of application of RMP deep into the core. In the core, a large reduction in E Multiplication-Sign B shear to a value below the linear growth rate, in conjunction with increasing density fluctuations, is consistent with an increase in turbulent particle transport. In the edge, the changes in turbulent particle transport are less obvious. There is a clear correlation between the linear growth rates and the density fluctuations measured at different scales, butmore » it is uncertain which is the cause and which is the consequence.« less

Changes in particle transport as a result of resonant magnetic perturbations in DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mordijck, S.; Doyle, E. J.; McKee, G. R.

2012-01-01

In this paper, we introduce the first direct perturbed particle transport measurements in resonant magnetic perturbation (RMP) H-mode plasmas. The perturbed particle transport increases as a result of application of RMP deep into the core. In the core, a large reduction in E x B shear to a value below the linear growth rate, in conjunction with increasing density fluctuations, is consistent with an increase in turbulent particle transport. In the edge, the changes in turbulent particle transport are less obvious. There is a clear correlation between the linear growth rates and the density fluctuations measured at different scales, butmore » it is uncertain which is the cause and which is the consequence.« less

Patterns of activity and body temperature of Aldabra giant tortoises in relation to environmental temperature.

PubMed

Falcón, Wilfredo; Baxter, Rich P; Furrer, Samuel; Bauert, Martin; Hatt, Jean-Michel; Schaepman-Strub, Gabriela; Ozgul, Arpat; Bunbury, Nancy; Clauss, Marcus; Hansen, Dennis M

2018-02-01

We studied the temperature relations of wild and zoo Aldabra giant tortoises ( Aldabrachelys gigantea ) focusing on (1) the relationship between environmental temperature and tortoise activity patterns ( n  = 8 wild individuals) and (2) on tortoise body temperature fluctuations, including how their core and external body temperatures vary in relation to different environmental temperature ranges (seasons; n  = 4 wild and n  = 5 zoo individuals). In addition, we surveyed the literature to review the effect of body mass on core body temperature range in relation to environmental temperature in the Testudinidae. Diurnal activity of tortoises was bimodally distributed and influenced by environmental temperature and season. The mean air temperature at which activity is maximized was 27.9°C, with a range of 25.8-31.7°C. Furthermore, air temperature explained changes in the core body temperature better than did mass, and only during the coldest trial, did tortoises with higher mass show more stable temperatures. Our results, together with the overall Testudinidae overview, suggest that, once variation in environmental temperature has been taken into account, there is little effect of mass on the temperature stability of tortoises. Moreover, the presence of thermal inertia in an individual tortoise depends on the environmental temperatures, and we found no evidence for inertial homeothermy. Finally, patterns of core and external body temperatures in comparison with environmental temperatures suggest that Aldabra giant tortoises act as mixed conformer-regulators. Our study provides a baseline to manage the thermal environment of wild and rewilded populations of an important island ecosystem engineer species in an era of climate change.

A persistent circhoral ultradian rhythm is identified in human core temperature.

PubMed

Lindsley, G; Dowse, H B; Burgoon, P W; Kolka, M A; Stephenson, L A

1999-01-01

There have been inconclusive reports of intermittent rhythmic fluctuations in human core temperature, with the fluctuations having a period of about an hour. However, there has been no definitive demonstration of the phenomenon. This is likely due to the intermittency and seeming instability of the events. They have been assumed to be secondary rather than autonomous phenomena, putatively arising from the oscillation between rapid eye movement (REM) and non-REM (NREM) sleep. In this study, we report identification of a clear, persistent circhoral ultradian rhythm in core temperature with a period for this study sample of 64 +/- 8 minutes. It appeared simultaneously with an intact circadian core temperature rhythm, persisted despite complex perturbations in core temperature brought about by the sequelae of 40 h of sleep deprivation, and could not be attributed to sleep stage alternation or other endogenous or exogenous factors. Analysis of power spectra using the maximum entropy spectral analysis (MESA) method, which can uncover hidden rhythmicities, demonstrated that the apparent intermittency of the rhythm is due to periodic interference of this rhythm by other rhythmic events. The persistence of this oscillation suggests that, in this system as in the endocrine system, circhoral regulation is an integral component of thermoregulatory control. Identifying the source and functional role of this novel rhythm warrants further work.

New technique for the direct measurement of core noise from aircraft engines

NASA Technical Reports Server (NTRS)

Krejsa, E. A.

1981-01-01

A new technique is presented for directly measuring the core noise levels from gas turbine aircraft engines. The technique requires that fluctuating pressures be measured in the far-field and at two locations within the engine core. The cross-spectra of these measurements are used to determine the levels of the far-field noise that propagated from the engine core. The technique makes it possible to measure core noise levels even when other noise sources dominate. The technique was applied to signals measured from an AVCO Lycoming YF102 turbofan engine. Core noise levels as a function of frequency and radiation angle were measured and are presented over a range of power settings.

Thermonuclear runaways in nova outbursts. 2: Effect of strong, instantaneous, local fluctuations

NASA Technical Reports Server (NTRS)

Shankar, Anurag; Arnett, David

1994-01-01

In an attempt to understand the manner in which nova outbursts are initiated on the surface of a white dwarf, we investigate the effects fluctuations have on the evolution of a thermonuclear runaway. Fluctuations in temperature density, or the composition of material in the burning shell may arise due to the chaotic flow field generated by convection when it occurs, or by the accretion process itself. With the aid of two-dimensional reactive flow calculations, we consider cases where a strong fluctutation in temperature arises during the early, quiescent accretion phase or during the later, more dynamic, explosion phase. In all cases we find that an instantaneous, local temperature fluctuation causes the affected material to become Rayleigh-Taylor unstable. The rapid rise and subsequent expansion of matter immediately cools the hot blob, which prevents the lateral propagation of burning. This suggests that local temperature fluctuations do not play a significant role in directly initiating the runaway, especially during the early stages. However, they may provide an efficient mechanism of mixing core material into the envelope (thereby pre-enriching the fuel for subsequent episodes of explosive hydrogen burning) and of mixing substantial amounts of the radioactive nucleus N-13 into the surface layers, making novae potential gamma-ray sources. This suggests that it is the global not the local, evolution of the core-envelope interface to high temperatures which dominates the development of the runaway. We also present a possible new scenario for the initiation of nova outbursts based on our results.

Solvation and Evolution Dynamics of an Excess Electron in Supercritical CO2

NASA Astrophysics Data System (ADS)

Wang, Zhiping; Liu, Jinxiang; Zhang, Meng; Cukier, Robert I.; Bu, Yuxiang

2012-05-01

We present an ab initio molecular dynamics simulation of the dynamics of an excess electron solvated in supercritical CO2. The excess electron can exist in three types of states: CO2-core localized, dual-core localized, and diffuse states. All these states undergo continuous state conversions via a combination of long lasting breathing oscillations and core switching, as also characterized by highly cooperative oscillations of the excess electron volume and vertical detachment energy. All of these oscillations exhibit a strong correlation with the electron-impacted bending vibration of the core CO2, and the core-switching is controlled by thermal fluctuations.

Mercury contribution to an Adirondack lake

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scrudato, R.J.; Long, D.; Weinbloom, R.

1987-01-01

Elevated copper, lead, and zinc concentrations in the upper 10 to 20 cm of sediment sampled from Cranberry Lake, a large Adirondack lake, are attributed to atmospheric contributions. Pb-210 and pollen core data, however, suggest Cranberry Lake also received mercury discharges during the turn of the century when the area was the center of extensive lumbering and related activities. Elevated mercury concentrations in Cranberry Lake smallmouth bass derived from remobilization from mercury-contaminated bottom sediments which increased the bioavailability to Cranberry Lake organisms. Mercury remobilization and accumulation by fish are promoted by fluctuating pH values resulting from acid precipitation.

Mercury contribution to an adirondack lake

NASA Astrophysics Data System (ADS)

Scrudato, R. J.; Long, D.; Weinbloom, Robert

1987-10-01

Elevated copper, lead, and zinc concentrations in the upper 10 to 20 cm of sediment sampled from Cranberry Lake, a large Adirondack lake, are attributed to atmospheric contributions. Pb-210 and pollen core data, however, suggest Cranberry Lake also received mercury discharges during the turn of the century when the area was the center of extensive lumbering and related activities. Elevated mercury concentrations in Cranberry Lake smallmouth bass derived from remobilization from mercury-contaminated bottom sediments which increased the bioavailability to Cranberry Lake organisms. Mercury remobilization and accumulation by fish are promoted by fluctuating pH values resulting from acid precipilation.

Development of an improved wearable device for core body temperature monitoring based on the dual heat flux principle.

PubMed

Feng, Jingjie; Zhou, Congcong; He, Cheng; Li, Yuan; Ye, Xuesong

2017-04-01

In this paper, a miniaturized wearable core body temperature (CBT) monitoring system based on the dual heat flux (DHF) principle was developed. By interspersing calcium carbonate powder in PolyDimethylsiloxane (PDMS), a reformative heat transfer medium was produced to reduce the thermal equilibrium time. Besides, a least mean square (LMS) algorithm based active noise cancellation (ANC) method was adopted to diminish the impact of ambient temperature fluctuations. Theoretical analyses, finite element simulation, experiments on a hot plate and human volunteers were performed. The results showed that the proposed system had the advantages of small size, reduced initial time (~23.5 min), and good immunity to fluctuations of the air temperature. For the range of 37-41 °C on the hot plate, the error compared with a Fluke high accuracy thermometer was 0.08  ±  0.20 °C. In the human experiments, the measured temperature in the rest trial (34 subjects) had a difference of 0.13  ±  0.22 °C compared with sublingual temperature, while a significant increase of 1.36  ±  0.44 °C from rest to jogging was found in the exercise trial (30 subjects). This system has the potential for reliable continuous CBT measurement in rest and can reflect CBT variations during exercise.

Record of Cyclical Massive Upwellings from the Pacific Large Low Shear Velocity Province in the Mesozoic

NASA Astrophysics Data System (ADS)

Gazel, E.; Madrigal, P.; Flores, K. E.; Bizimis, M.; Jicha, B. R.

2016-12-01

Global tomography and numerical models suggest that mantle plume occurrences are closely linked to the margins of the large low shear velocity provinces (LLSVPs). In these locations the ascent of material from the core-mantle boundary connects the deep Earth with surface processes through mantle plume activity, forming large igneous provinces (LIPs) and some of the modern hotspot volcanoes. Petrological and geodynamic evidence suggest a link between the formation of oceanic plateaus and the interactions of mantle plumes and mid-ocean ridges (MOR). Therefore, it is possible to trace the potential interactions between MORs and deep mantle plume upwellings by referencing the tectonic and magmatic evolution of the Pacific Plate in time to the current location of the LLSVP, considering the long-lived ( 500 Ma) existence of these thermochemical anomalies. We identified episodic upwellings of the Pacific LLSVP during the Mesozoic separated by 10 to 20 Ma, by reconstructing the kinematic evolution of the Pacific Plate in the last 170 Ma. The fact that the bulk emplacement of LIPs ( 120-80 Ma) in the Pacific coincides with the timing of the Cretaceous Normal Superchron, that can be related to fluctuations of mantle-core heat fluxes further supports the hypothesis of deep mantle origin for LIPs. The potential cyclicity of LIP emplacement could be tied to core heat fluctuations interacting with the lower mantle, the rheology contrast of material crossing the transition zone (either upwelling hot material or downgoing dense slabs as mantle avalanches), the rate of entrainment of recycled materials, or a combination of the processes mentioned. Recognizing patterns and possible cycles is crucial to the link between deep processes and life as these pulses impacted the marine biota resulting in episodes of anoxia and mass extinctions shortly after their eruption.

Equilibrium fitting analysis and propagation of magnetic fluctuations in the Multi-pulsing HIST plasmas

NASA Astrophysics Data System (ADS)

Matsumoto, K.; Hanano, T.; Ito, K.; Ishihara, M.; Higashi, T.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.

2011-10-01

The current drive by Multi-pulsing Coaxial Helicity Injection (M-CHI) has been performed on HIST in a wide range of configurations from high-q ST to low-q ST and spheromak generated by the utilization of the toroidal field. It is a key issue to investigate the dynamo mechanism required to maintain each configuration. To identify the detail mechanisms regarding a helicity transport from the edge to the core region, we have investigated the characteristics of magnetic field fluctuations observed in M- CHI experiments. We have fitted internal magnetic field data to a ST configuration calculated by the equilibrium code with a hollow pressure profile in order to find the sustained configurations. Fluctuation frequency is identified as about 80 kHz and it has been found to propagate from the open flux column region toward the core region. The toroidal mode n=0 is dominant in the high TF coil current operation. Alfven wave generation has been identified by evaluating its velocity as a function of plasma density or magnetic field strength. We will discuss the relationship between the Alfven wave and helicity propagation.

[Study on the fluctuation phenomena of arc plasma spraying jet].

PubMed

Zhao, Wen-hua; Liu, Di; Tian, Kuo

2002-08-01

The turbulence phenomenon is one of the most attractive characteristics of a DC arc plasma spraying jet. Most of the previous investigations believe that there is a laminar flow region in core of the jet. A spectrum diagnostic system has been built up in this paper to investigate these effects with the aid of high-speed digital camera. The FFT method has been applied to the analysis on the arc voltage and light signals. The influence of the arc behavior and the power supply on the jet is full-scale. It seems that there is not a laminar flow region in core of the jet. Moreover, from the light dynamic variation graph, the jet fluctuation due to the arc voltage behavior maybe is the dominant characteristic of the jet behavior.

Experimental observation of multi-scale interactions among kink /tearing modes and high-frequency fluctuations in the HL-2A core NBI plasmas

NASA Astrophysics Data System (ADS)

Chen, W.; Jiang, M.; Xu, Y.; Shi, P. W.; Yu, L. M.; Ding, X. T.; Shi, Z. B.; Ji, X. Q.; Yu, D. L.; Li, Y. G.; Yang, Z. C.; Zhong, W. L.; Qiu, Z. Y.; Li, J. Q.; Dong, J. Q.; Yang, Q. W.; Liu, Yi.; Yan, L. W.; Xu, M.; Duan, X. R.

2017-11-01

Multi-scale interactions have been observed recently in the HL-2A core NBI plasmas, including the synchronous coupling between m/n=1/1 kink mode and m/n=2/1 tearing mode, nonlinear couplings of TAE/BAE and m/n=2/1 TM near q=2 surface, AITG/KBM/BAE and m/n=1/1 kink mode near q=1 surface, and between m/n=1/1 kink mode and high-frequency turbulence. Experimental results suggest that several couplings can exist simultaneously, Alfvenic fluctuations have an important contribution to the high-frequency turbulence spectra, and the couplings reveal the electromagnetic character. Multi-scale interactions via the nonlinear modulation process maybe enhance plasma transport and trigger sawtooth-crash onset.

Quantum dot-like emitters formed due to alloy fluctuations in GaNAs-based nanowires.

NASA Astrophysics Data System (ADS)

Buyanova, Irina; Jansson, M.; Filippov, S.; Stehr, J.; Palisaitis, J.; Persson, P.; Ishikawa, F.; Chen, Weimin

Group III-V semiconductor nanowires with embedded quantum dots (QDs) are currently attracting increasing attention as a highly attractive platform for a variety of advanced applications ranging from third generation photovoltaics to quantum information technologies. In this work, we show that local fluctuations in N composition inside coaxial GaAs/GaNAs nanowires induces three-dimensional confining potentials equivalent to that for QDs thus forming optically active and highly localized states inside the GaNAs shell. Principal quantization axis of these states is concluded to mainly coincide with the nanowire axis, based on the strong polarization of the detected emission orthogonal to the nanowire axis revealed from polarization-resolved micro-photoluminescence studies. This is partly attributed to a predominantly uniaxial tensile strain field in the GaNAs shell caused by lattice mismatch with the GaAs core. GaNAs alloys can, therefore, be used as an active material in hybrid QD-NW structures utilized for fabrication of nanoscale polarized-light sources that are efficient within the near-infrared spectral range. Financial support by the Swedish Energy Agency (Grant # P40119-1) and the Swedish Research Council (Grant # 2015-05532) is greatly appreciated.

Daily fluctuation of hepatic P450 monooxygenase activities in male rats is controlled by the suprachiasmatic nucleus but remains unaffected by adrenal hormones.

PubMed

Furukawa, T; Manabe, S; Watanabe, T; Sehata, S; Sharyo, S; Okada, T; Mori, Y

1999-09-01

Hepatic P450 monooxygenase activities, which strongly influence the efficacy and/or toxicity of drugs, are known to fluctuate daily. We also know that the P450 activities assessed by measurement of 7-alkoxycoumarin O-dealkylase (ACD) activities fluctuate daily, with apparently high values during the dark period in male rats. However, there is little knowledge about the factors that regulate daily fluctuation of P450 monooxygenase activities. In the present study using rats, we induced lesions in the suprachiasmatic nucleus (SCN) of the brain, the known site of the body's internal clock, and examined the effects on the daily fluctuation of the ACD activities to clarify the relationship between the SCN and the daily fluctuation of P450 monooxygenase activities. In addition, adrenalectomy was performed to re-evaluate the influence of adrenal hormones on the P450 activities. Our results indicated that daily fluctuations of the hepatic ACD activities were completely eliminated in the SCN-lesioned rats. However, the ACD activities in the adrenalectomized rats showed apparent daily fluctuations with high values during the dark period and low values during the light period. Therefore, this study demonstrated that the daily fluctuation of the hepatic P450 monooxygenase activities in male rats is controlled by the SCN but remains unaffected by the adrenal hormones.

Fluctuation-dissipation theorem in an isolated system of quantum dipolar bosons after a quench.

PubMed

Khatami, Ehsan; Pupillo, Guido; Srednicki, Mark; Rigol, Marcos

2013-08-02

We examine the validity of fluctuation-dissipation relations in isolated quantum systems taken out of equilibrium by a sudden quench. We focus on the dynamics of trapped hard-core bosons in one-dimensional lattices with dipolar interactions whose strength is changed during the quench. We find indications that fluctuation-dissipation relations hold if the system is nonintegrable after the quench, as well as if it is integrable after the quench if the initial state is an equilibrium state of a nonintegrable Hamiltonian. On the other hand, we find indications that they fail if the system is integrable both before and after quenching.

Convectively driven decadal zonal accelerations in Earth's fluid core

NASA Astrophysics Data System (ADS)

More, Colin; Dumberry, Mathieu

2018-04-01

Azimuthal accelerations of cylindrical surfaces co-axial with the rotation axis have been inferred to exist in Earth's fluid core on the basis of magnetic field observations and changes in the length-of-day. These accelerations have a typical timescale of decades. However, the physical mechanism causing the accelerations is not well understood. Scaling arguments suggest that the leading order torque averaged over cylindrical surfaces should arise from the Lorentz force. Decadal fluctuations in the magnetic field inside the core, driven by convective flows, could then force decadal changes in the Lorentz torque and generate zonal accelerations. We test this hypothesis by constructing a quasi-geostrophic model of magnetoconvection, with thermally driven flows perturbing a steady, imposed background magnetic field. We show that when the Alfvén number in our model is similar to that in Earth's fluid core, temporal fluctuations in the torque balance are dominated by the Lorentz torque, with the latter generating mean zonal accelerations. Our model reproduces both fast, free Alfvén waves and slow, forced accelerations, with ratios of relative strength and relative timescale similar to those inferred for the Earth's core. The temporal changes in the magnetic field which drive the time-varying Lorentz torque are produced by the underlying convective flows, shearing and advecting the magnetic field on a timescale associated with convective eddies. Our results support the hypothesis that temporal changes in the magnetic field deep inside Earth's fluid core drive the observed decadal zonal accelerations of cylindrical surfaces through the Lorentz torque.

Links between Patagonian Ice Sheet fluctuations and Antarctic dust variability during the last glacial period (MIS 4-2)

NASA Astrophysics Data System (ADS)

Kaiser, Jérôme; Lamy, Frank

2010-06-01

Antarctic and Greenland ice-core records reveal large fluctuations of dust input on both orbital and millennial time-scales with potential global climate implications. At least during glacial periods, the Antarctic dust fluctuations appear to be largely controlled by environmental changes in southern South America. We compare dust flux records from two Antarctic ice-cores to variations in the composition of the terrigenous supply at ODP Site 1233 located off southern Chile and known to record fluctuations in the extent of the northern part of the Patagonian ice-sheet (NPIS) during the last glacial period (Marine Isotope Stage, MIS, 4 to 2). Within age uncertainties, millennial-scale glacial advances (retreats) of the NPIS correlate to Antarctic dust maxima (minima). In turn, NPIS fluctuations were closely related to offshore sea surface temperature (SST) changes. This pattern suggests a causal link involving changes in temperature, in rock flour availability, in latitudinal extensions of the westerly winds and in foehn winds in the southern Pampas and Patagonia. We further suggest that the long-term trend of dust accumulation is partly linked to the sea-level related changes in the size if the Patagonian source area due to the particular morphology of the Argentine shelf. We suggest that sea-level drops at the beginning of MIS 4 and MIS 2 were important for long-term dust increases, while changes in the Patagonian dust source regions primarily control the early dust decrease during the MIS 4/3 transition and Termination 1.

Self-assembly of BODIPY based pH-sensitive near-infrared polymeric micelles for drug controlled delivery and fluorescence imaging applications

NASA Astrophysics Data System (ADS)

Liu, Xiaodong; Chen, Bizheng; Li, Xiaojun; Zhang, Lifen; Xu, Yujie; Liu, Zhuang; Cheng, Zhenping; Zhu, Xiulin

2015-10-01

Responsive block copolymer micelles emerging as promising imaging and drug delivery systems show high stability and on-demand drug release activities. Herein, we developed self-assembled pH-responsive NIR emission micelles entrapped with doxorubicin (DOX) within the cores by the electrostatic interactions for fluorescence imaging and chemotherapy applications. The block copolymer, poly(methacrylic acid)-block-poly[(poly(ethylene glycol) methyl ether methacrylate)-co-boron dipyrromethene derivatives] (PMAA-b-P(PEGMA-co-BODIPY)), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and the molecular weight distribution of this copolymer was narrow (Mw/Mn = 1.31). The NIR fluorescence enhancement induced by the phenol/phenolate interconversion equilibrium works as a switch in response to the intracellular pH fluctuations. DOX-loaded PMAA-b-P(PEGMA-co-BODIPY) micelles can detect the physiological pH fluctuations with a pKa near physiological conditions (~7.52), and showed pH-responsive collapse and an obvious acid promoted anticancer drug release behavior (over 58.8-62.8% in 10 h). Real-time imaging of intracellular pH variations was performed and a significant chemotherapy effect was demonstrated against HeLa cells.Responsive block copolymer micelles emerging as promising imaging and drug delivery systems show high stability and on-demand drug release activities. Herein, we developed self-assembled pH-responsive NIR emission micelles entrapped with doxorubicin (DOX) within the cores by the electrostatic interactions for fluorescence imaging and chemotherapy applications. The block copolymer, poly(methacrylic acid)-block-poly[(poly(ethylene glycol) methyl ether methacrylate)-co-boron dipyrromethene derivatives] (PMAA-b-P(PEGMA-co-BODIPY)), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and the molecular weight distribution of this copolymer was narrow (Mw/Mn = 1.31). The NIR fluorescence enhancement induced by the phenol/phenolate interconversion equilibrium works as a switch in response to the intracellular pH fluctuations. DOX-loaded PMAA-b-P(PEGMA-co-BODIPY) micelles can detect the physiological pH fluctuations with a pKa near physiological conditions (~7.52), and showed pH-responsive collapse and an obvious acid promoted anticancer drug release behavior (over 58.8-62.8% in 10 h). Real-time imaging of intracellular pH variations was performed and a significant chemotherapy effect was demonstrated against HeLa cells. Electronic supplementary information (ESI) available: GPC, UV/vis, fluorescence, and MTT data of the as-prepared polymers; 1H NMR, 13C NMR, HRMS and FT-IR of organic molecules and polymers. See DOI: 10.1039/c5nr04655f

Active Brownian particles with velocity-alignment and active fluctuations

NASA Astrophysics Data System (ADS)

Großmann, R.; Schimansky-Geier, L.; Romanczuk, P.

2012-07-01

We consider a model of active Brownian particles (ABPs) with velocity alignment in two spatial dimensions with passive and active fluctuations. Here, active fluctuations refers to purely non-equilibrium stochastic forces correlated with the heading of an individual active particle. In the simplest case studied here, they are assumed to be independent stochastic forces parallel (speed noise) and perpendicular (angular noise) to the velocity of the particle. On the other hand, passive fluctuations are defined by a noise vector independent of the direction of motion of a particle, and may account, for example, for thermal fluctuations. We derive a macroscopic description of the ABP gas with velocity-alignment interaction. Here, we start from the individual-based description in terms of stochastic differential equations (Langevin equations) and derive equations of motion for the coarse-grained kinetic variables (density, velocity and temperature) via a moment expansion of the corresponding probability density function. We focus here on the different impact of active and passive fluctuations on onset of collective motion and show how active fluctuations in the active Brownian dynamics can change the phase-transition behaviour of the system. In particular, we show that active angular fluctuations lead to an earlier breakdown of collective motion and to the emergence of a new bistable regime in the mean-field case.

Is propensity to obesity associated with the diurnal pattern of core body temperature?

PubMed

Hynd, P I; Czerwinski, V H; McWhorter, T J

2014-02-01

Obesity affects more than half a billion people worldwide, but the underlying causes remain unresolved. It has been proposed that propensity to obesity may be associated with differences between individuals in metabolic efficiency and in the energy used for homeothermy. It has also been suggested that obese-prone individuals differ in their responsiveness to circadian rhythms. We investigated both these hypotheses by measuring the core body temperature at regular and frequent intervals over a diurnal cycle, using indigestible temperature loggers in two breeds of canines known to differ in propensity to obesity, but prior to divergence in fatness. Greyhounds (obesity-resistant) and Labradors (obesity-prone) were fed indigestible temperature loggers. Gastrointestinal temperature was recorded at 10-min intervals for the period of transit of the logger. Diet, body condition score, activity level and environment were similar for both groups. Energy digestibility was also measured. The mean core body temperature in obesity-resistant dogs (38.27 °C) was slightly higher (P<0.001) than in obesity-prone dogs (38.18 °C) and the former had a greater variation (P<0.001) in 24h circadian core temperature. There were no differences in diet digestibility. Canines differing in propensity to obesity, but prior to its onset, differed little in mean core temperature, supporting similar findings in already-obese and lean humans. Obese-prone dogs were less variable in daily core temperature fluctuations, suggestive of a degree of circadian decoupling.

Fabrication and Characterization of Miniaturized Thermocouples

NASA Astrophysics Data System (ADS)

Munzel, Marco; Peinke, Joachim; Kittel, Achim

2002-11-01

The measurement of thermal fluctuations is important for discovering transport features of a passive scalar in fluids. We present a thermal sensor based on a miniaturized thermocouple. Its coaxial setup results from the fabrication as a micropipette normally used in neurobiology. The glass micropipettes contain a core of gold, antimony, or resistance wire and are coated with platinum. The core material is inserted as molten metal or wire and thinned during the fabrication process. The achieved tip diameters are 1μm and less which enhance the spatial and temporal resolution significantly. Because of its chemically inert coating, these sensors are applicative for detecting temperature fluctuations in large variety of liquids and gases. In addition, such thermocouples are intrinsically suitable for applications in scanning probe microscopy. The characterization of these sensors and first results from turbulent free-jet measurements are presented.

Differential Rotation within the Earth's Outer Core

NASA Technical Reports Server (NTRS)

Hide, R.; Boggs, D. H.; Dickey, J. O.

1998-01-01

Non-steady differential rotation drive by bouyancy forces within the Earth's liquid outer core (OC) plays a key role not only in the generation of the main geomagnetic field by the magnetohydrodynamic (MHD) dynamo process but also in the excitation of irregular fluctuations in the angular speed of rotation of the overlying solid mantle, as evidenced by changes in the length of the day (LOD) on decadal and longer timescales (1-8).

Kinematic reversal schemes for the geomagnetic dipole.

NASA Technical Reports Server (NTRS)

Levy, E. H.

1972-01-01

Fluctuations in the distribution of cyclonic convective cells, in the earth's core, can reverse the sign of the geomagnetic field. Two kinematic reversal schemes are discussed. In the first scheme, a field maintained by cyclones concentrated at low latitude is reversed by a burst of cyclones at high latitude. Conversely, in the second scheme, a field maintained predominantly by cyclones in high latitudes is reversed by a fluctuation consisting of a burst of cyclonic convection at low latitude. The precise fluid motions which produce the geomagnetic field are not known. However, it appears that, whatever the details are, a fluctuation in the distribution of cyclonic cells over latitude can cause a geomagnetic reversal.

Deep Chandra observations of the stripped galaxy group falling into Abell 2142

NASA Astrophysics Data System (ADS)

Eckert, D.; Gaspari, M.; Owers, M. S.; Roediger, E.; Molendi, S.; Gastaldello, F.; Paltani, S.; Ettori, S.; Venturi, T.; Rossetti, M.; Rudnick, L.

2017-09-01

In the local Universe, the growth of massive galaxy clusters mainly operates through the continuous accretion of group-scale systems. The infalling group in Abell 2142 is the poster child of such an accreting group, and as such, it is an ideal target to study the astrophysical processes induced by structure formation. We present the results of a deep (200 ks) observation of this structure with Chandra that highlights the complexity of this system in exquisite detail. In the core of the group, the spatial resolution of Chandra reveals a leading edge and complex AGN-induced activity. The morphology of the stripped gas tail appears straight in the innermost 250 kpc, suggesting that magnetic draping efficiently shields the gas from its surroundings. However, beyond 300 kpc from the core, the tail flares and the morphology becomes strongly irregular, which could be explained by a breaking of the drape, for example, caused by turbulent motions. The power spectrum of surface-brightness fluctuations is relatively flat (P2D ∝ k-2.3), which indicates that thermal conduction is strongly inhibited even beyond the region where magnetic draping is effective. The amplitude of density fluctuations in the tail is consistent with a mild level of turbulence with a Mach number M3D 0.1 - 0.25. Overall, our results show that the processes leading to the thermalization and mixing of the infalling gas are slow and relatively inefficient.

Measurements of dynamo electric field and momentum transport induced by fluctuations on HIST

NASA Astrophysics Data System (ADS)

Hirono, H.; Hanao, T.; Hyobu, T.; Ito, K.; Matsumoto, K.; Nakayama, T.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.

2012-10-01

Coaxial Helicity injection (CHI) is an efficient current-drive method used in spheromak and spherical torus (ST) experiments. It is an important issue to investigate dynamo effect to explore CHI current drive mechanisms. To establish the dynamo model with two-fluid Hall effects, we verify the parallel mean-field Ohm's law balance. The spatial profiles of the MHD/Hall dynamo electric fields are measured by using Mach probe and Hall probe involving 3-axis magnetic pick-up coils. The MHD/Hall fluctuation-induced electromotive forces are large enough to sustain the mean toroidal current against the resistive decay. We have measured the electron temperature and the density with great accuracy by using a new electrostatic probe with voltage sweeping. The result shows that the electron temperature is high in the core region and low in the central open flux column (OFC), and the electron density is highest in the OFC region. The Hall dynamo becomes more dominant in a lower density region compared to the MHD dynamo. In addition, the fluctuation-induced Maxwell and Reynolds stresses are calculated to examine the fast radial transport of momentum from the OFC to the core region during the dynamo drive.

First-order finite-Larmor-radius fluid modeling of tearing and relaxation in a plasma pincha)

NASA Astrophysics Data System (ADS)

King, J. R.; Sovinec, C. R.; Mirnov, V. V.

2012-05-01

Drift and Hall effects on magnetic tearing, island evolution, and relaxation in pinch configurations are investigated using a non-reduced first-order finite-Larmor-radius (FLR) fluid model with the nonideal magnetohydrodynamics (MHD) with rotation, open discussion (NIMROD) code [C.R. Sovinec and J. R. King, J. Comput. Phys. 229, 5803 (2010)]. An unexpected result with a uniform pressure profile is a drift effect that reduces the growth rate when the ion sound gyroradius (ρs) is smaller than the tearing-layer width. This drift is present only with warm-ion FLR modeling, and analytics show that it arises from ∇B and poloidal curvature represented in the Braginskii gyroviscous stress. Nonlinear single-helicity computations with experimentally relevant ρs values show that the warm-ion gyroviscous effects reduce saturated-island widths. Computations with multiple nonlinearly interacting tearing fluctuations find that m = 1 core-resonant-fluctuation amplitudes are reduced by a factor of two relative to single-fluid modeling by the warm-ion effects. These reduced core-resonant-fluctuation amplitudes compare favorably to edge coil measurements in the Madison Symmetric Torus (MST) reversed-field pinch [R. N. Dexter et al., Fusion Technol. 19, 131 (1991)]. The computations demonstrate that fluctuations induce both MHD- and Hall-dynamo emfs during relaxation events. The presence of a Hall-dynamo emf implies a fluctuation-induced Maxwell stress, and the simulation results show net transport of parallel momentum. The computed magnitude of force densities from the Maxwell and competing Reynolds stresses, and changes in the parallel flow profile, are qualitatively and semi-quantitatively similar to measurements during relaxation in MST.

First-order finite-Larmor-radius fluid modeling of tearing and relaxation in a plasma pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, J. R.; Tech-X Corporation, 5621 Arapahoe Ave., Suite A Boulder, Colorado 80303; Sovinec, C. R.

Drift and Hall effects on magnetic tearing, island evolution, and relaxation in pinch configurations are investigated using a non-reduced first-order finite-Larmor-radius (FLR) fluid model with the nonideal magnetohydrodynamics (MHD) with rotation, open discussion (NIMROD) code [C.R. Sovinec and J. R. King, J. Comput. Phys. 229, 5803 (2010)]. An unexpected result with a uniform pressure profile is a drift effect that reduces the growth rate when the ion sound gyroradius ({rho}{sub s}) is smaller than the tearing-layer width. This drift is present only with warm-ion FLR modeling, and analytics show that it arises from {nabla}B and poloidal curvature represented in themore » Braginskii gyroviscous stress. Nonlinear single-helicity computations with experimentally relevant {rho}{sub s} values show that the warm-ion gyroviscous effects reduce saturated-island widths. Computations with multiple nonlinearly interacting tearing fluctuations find that m = 1 core-resonant-fluctuation amplitudes are reduced by a factor of two relative to single-fluid modeling by the warm-ion effects. These reduced core-resonant-fluctuation amplitudes compare favorably to edge coil measurements in the Madison Symmetric Torus (MST) reversed-field pinch [R. N. Dexter et al., Fusion Technol. 19, 131 (1991)]. The computations demonstrate that fluctuations induce both MHD- and Hall-dynamo emfs during relaxation events. The presence of a Hall-dynamo emf implies a fluctuation-induced Maxwell stress, and the simulation results show net transport of parallel momentum. The computed magnitude of force densities from the Maxwell and competing Reynolds stresses, and changes in the parallel flow profile, are qualitatively and semi-quantitatively similar to measurements during relaxation in MST.« less

Three-beam coherent combination experiments based on segmented mirrors and measure of phase characteristics of beams passing through Yb-doped fiber amplifier

NASA Astrophysics Data System (ADS)

Yang, Ping; Yang, Ruo fu; Shen, Feng; Ao, Mingwu; Jiang, Wenhan

2009-05-01

Coherent combination is one of the most promising ways to realize high power laser output. A three- laser-beam coherent combination system based on adaptive optics (AO) technique has been set up in our laboratory. In this system, three 1064nm laser beams are placed side-by-side and compressed by two reflective mirrors. An active segmented deformable mirror (DM) is used to compensate the optical path difference (OPD) among three laser beams. The beams are overlapped onto a 2900Hz CCD camera to form an interference pattern while the peak intensity of the interference pattern is taken as the cost function to optimize by a stochastic parallel gradient descent (SPGD) algorithm. SPGD algorithm is realized on a RT-Linux dual-core industrial computer. A series of experiments have been accomplished and experimental results show that both static distorted aberrations in the beams and active distorted aberrations (which are brought in by a hot iron and the frequency is about 5Hz) can be compensated successfully when the gain coefficients and the perturbation amplitude of SPGD are chosed appropriately, thereby three beams can be well combined. For controlling the phase of fiber lasers, the phase characteristics of beams passing through Yb-doped dual-clad fiber amplifier are measured by means of investigating the interference pattern under different output power through experiments. The frequency of phase fluctuation is evaluated through analyzing the fluctuation of power within a 90um aperture of far-field focal spot. Experimental results show that the phase fluctuation frequencies of laser beam transmitted through fiber amplifier are mainly in the range of 100~1500Hz. As a result, to control the phase fluctuation of beams passing through fiber amplifier, the bandwidth of any potential phase control scheme must be greater than 1.5 kilohertz.

Regional synchrony in full-scale activated sludge bioreactors due to deterministic microbial community assembly

PubMed Central

Griffin, James S; Wells, George F

2017-01-01

Seasonal community structure and regionally synchronous population dynamics have been observed in natural microbial ecosystems, but have not been well documented in wastewater treatment bioreactors. Few studies of community dynamics in full-scale activated sludge systems facing similar meteorological conditions have been done to compare the importance of deterministic and neutral community assembly mechanisms. We subjected weekly activated sludge samples from six regional full-scale bioreactors at four wastewater treatment plants obtained over 1 year to Illumina sequencing of 16S ribosomal RNA genes, resulting in a library of over 17 million sequences. All samples derived from reactors treating primarily municipal wastewater. Despite variation in operational characteristics and location, communities displayed temporal synchrony at the individual operational taxonomic unit (OTU), broad phylogenetic affiliation and community-wide scale. Bioreactor communities were dominated by 134 abundant and highly regionally synchronized OTU populations that accounted for over 50% of the total reads. Non-core OTUs displayed abundance-dependent population synchrony. Alpha diversity varied by reactor, but showed a highly reproducible and synchronous seasonal fluctuation. Community similarity was dominated by seasonal changes, but individual reactors maintained minor stable differences after 1 year. Finally, the impacts of mass migration driven by direct biomass transfers between reactors was investigated, but had no significant effect on community similarity or diversity in the sink community. Our results show that population dynamics in activated sludge bioreactors are consistent with niche-driven assembly guided by seasonal temperature fluctuations. PMID:27996980

Thermal interaction of the core and the mantle and long-term behavior of the geomagnetic field

NASA Technical Reports Server (NTRS)

Jones, G. M.

1977-01-01

The effects of temperature changes at the earth's core-mantle boundary on the velocity field of the core are analyzed. It is assumed that the geomagnetic field is maintained by thermal convection in the outer core. A model for the thermal interaction of the core and the mantle is presented which is consistent with current views on the presence of heat sources in the core and the properties of the lower mantle. Significant long-term variations in the frequency of geomagnetic reversals may be the result of fluctuating temperatures at the core-mantle boundary, caused by intermittent convection in the lower mantle. The thermal structure of the lower mantle region D double prime, extending from 2700 to 2900 km in depth, constitutes an important test of this hypothesis and offers a means of deciding whether the geomagnetic dynamo is thermally driven.

Thermal and active fluctuations of a compressible bilayer vesicle

NASA Astrophysics Data System (ADS)

Sachin Krishnan, T. V.; Yasuda, Kento; Okamoto, Ryuichi; Komura, Shigeyuki

2018-05-01

We discuss thermal and active fluctuations of a compressible bilayer vesicle by using the results of hydrodynamic theory for vesicles. Coupled Langevin equations for the membrane deformation and the density fields are employed to calculate the power spectral density matrix of membrane fluctuations. Thermal contribution is obtained by means of the fluctuation dissipation theorem, whereas active contribution is calculated from exponentially decaying time correlation functions of active random forces. We obtain the total power spectral density as a sum of thermal and active contributions. An apparent response function is further calculated in order to compare with the recent microrheology experiment on red blood cells. An enhanced response is predicted in the low-frequency regime for non-thermal active fluctuations.

Microbial communities acclimate to recurring changes in soil redox potential status

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeAngelis, Kristen M.; Silver, Whendee; Thompson, Andrew

Rapidly fluctuating environmental conditions can significantly stress organisms, particularly when fluctuations cross thresholds of normal physiological tolerance. Redox potential fluctuations are common in humid tropical soils, and microbial community acclimation or avoidance strategies for survival will in turn shape microbial community diversity and biogeochemistry. To assess the extent to which indigenous bacterial and archaeal communities are adapted to changing in redox potential, soils were incubated under static anoxic, static oxic or fluctuating redox potential conditions, and the standing (DNA-based) and active (RNA-based) communities and biogeochemistry were determined. Fluctuating redox potential conditions permitted simultaneous CO{sub 2} respiration, methanogenesis, N{sub 2}O productionmore » and iron reduction. Exposure to static anaerobic conditions significantly changed community composition, while 4-day redox potential fluctuations did not. Using RNA: DNA ratios as a measure of activity, 285 taxa were more active under fluctuating than static conditions, compared with three taxa that were more active under static compared with fluctuating conditions. These data suggest an indigenous microbialcommunity adapted to fluctuating redox potential.« less

Magnetic susceptibility as a proxy for the hydrobiogeochemical cycling of iron within the water table fluctuation zone at hydrocarbon contaminated sites

NASA Astrophysics Data System (ADS)

Atekwana, E. A.; Enright, A.; Atekwana, E. A.; Beaver, C. L.; Rossbach, S.; Slater, L. D.; Ntarlagiannis, D.

2016-12-01

Sharp redox gradients are indicative of enhanced biogeochemical activity and occur at or near the water table. Hydrologic forcing drives changes in redox state and oxygen levels, enhancing the elemental cycling of metals, and coupling different biogeochemical cycles. These coupled hydrobiogeochemical cycles are often difficult to study in the field using geochemical and microbial proxies because of direct sampling limitations, the costs associated with these techniques, and because the dynamic nature of these processes complicates the interpretation of single time point measurements, which may not give accurate representations of prevailing conditions. Geophysical techniques can provide both the spatial and temporal resolution needed to elucidate these processes. Here we investigated the use of magnetic susceptibility (c) as a viable proxy for understanding the biogeochemical cycling of iron at several hydrocarbon contaminated sites where active intrinsic bioremediation is occurring. We performed borehole c logging using a Bartington c probe in the field as well as made c measurements on core samples retrieved from the field sites. Our results show the following: (1) in both sulfate-rich and sulfate-poor aquifers, excursions in c are coincident with zones of free product contamination and are limited to the water table fluctuation (smear) zone; (2) c values within the free product plume and contamination source zones are higher compared to values within the dissolved product plume; (3) high c coincides with zones of elevated Fe (II) and Fe (III) concentrations extracted from aquifer solids; and (4) the mixed valence magnetite and greigite were the dominant magnetic minerals. The c excursions are limited to the water table fluctuation zones because fluctuating water level conditions are hot beds for microbial activity due to the steep hydrocarbon and nutrients and consequently redox gradients. High water levels during periods of recharge favor anaerobic conditions enhancing iron reduction, while low water conditions during drought periods favor iron oxidation due to increased oxygen penetration. Such conditions favor mixed valent iron minerals such as magnetite and greigite. We conclude that c measurements are a low cost, rapid monitoring tool for assessing the elemental cycling of iron.

Pluvial lakes in the Great Basin of the western United States: a view from the outcrop

USGS Publications Warehouse

Reheis, Marith C.; Adams, Kenneth D.; Oviatt, Charles G.; Bacon, Steven N.

2014-01-01

Paleo-lakes in the western United States provide geomorphic and hydrologic records of climate and drainage-basin change at multiple time scales extending back to the Miocene. Recent reviews and studies of paleo-lake records have focused on interpretations of proxies in lake sediment cores from the northern and central parts of the Great Basin. In this review, emphasis is placed on equally important studies of lake history during the past ∼30 years that were derived from outcrop exposures and geomorphology, in some cases combined with cores. Outcrop and core records have different strengths and weaknesses that must be recognized and exploited in the interpretation of paleohydrology and paleoclimate. Outcrops and landforms can yield direct evidence of lake level, facies changes that record details of lake-level fluctuations, and geologic events such as catastrophic floods, drainage-basin changes, and isostatic rebound. Cores can potentially yield continuous records when sampled in stable parts of lake basins and can provide proxies for changes in lake level, water temperature and chemistry, and ecological conditions in the surrounding landscape. However, proxies such as stable isotopes may be influenced by several competing factors the relative effects of which may be difficult to assess, and interpretations may be confounded by geologic events within the drainage basin that were unrecorded or not recognized in a core. The best evidence for documenting absolute lake-level changes lies within the shore, nearshore, and deltaic sediments that were deposited across piedmonts and at the mouths of streams as lake level rose and fell. We review the different shorezone environments and resulting deposits used in such reconstructions and discuss potential estimation errors. Lake-level studies based on deposits and landforms have provided paleohydrologic records ranging from general changes during the past million years to centennial-scale details of fluctuations during the late Pleistocene and Holocene. Outcrop studies have documented the integration histories of several important drainage basins, including the Humboldt, Amargosa, Owens, and Mojave river systems, that have evolved since the Miocene within the active tectonic setting of the Great Basin; these histories have influenced lake levels in terminal basins. Many pre-late Pleistocene lakes in the western Great Basin were significantly larger and record wetter conditions than the youngest lakes. Outcrop-based lake-level data provide important checks on core-based proxy interpretations; we discuss four such comparisons. In some cases, such as for Lakes Owens and Manix, outcrop and core data synthesis yields stronger and more complete records; in other cases, such as for Bonneville and Lahontan, conflicts point toward reconsideration of confounding factors in interpretation of core-based proxies.

Sequence composition and environment effects on residue fluctuations in protein structures

NASA Astrophysics Data System (ADS)

Ruvinsky, Anatoly M.; Vakser, Ilya A.

2010-10-01

Structure fluctuations in proteins affect a broad range of cell phenomena, including stability of proteins and their fragments, allosteric transitions, and energy transfer. This study presents a statistical-thermodynamic analysis of relationship between the sequence composition and the distribution of residue fluctuations in protein-protein complexes. A one-node-per-residue elastic network model accounting for the nonhomogeneous protein mass distribution and the interatomic interactions through the renormalized inter-residue potential is developed. Two factors, a protein mass distribution and a residue environment, were found to determine the scale of residue fluctuations. Surface residues undergo larger fluctuations than core residues in agreement with experimental observations. Ranking residues over the normalized scale of fluctuations yields a distinct classification of amino acids into three groups: (i) highly fluctuating-Gly, Ala, Ser, Pro, and Asp, (ii) moderately fluctuating-Thr, Asn, Gln, Lys, Glu, Arg, Val, and Cys, and (iii) weakly fluctuating-Ile, Leu, Met, Phe, Tyr, Trp, and His. The structural instability in proteins possibly relates to the high content of the highly fluctuating residues and a deficiency of the weakly fluctuating residues in irregular secondary structure elements (loops), chameleon sequences, and disordered proteins. Strong correlation between residue fluctuations and the sequence composition of protein loops supports this hypothesis. Comparing fluctuations of binding site residues (interface residues) with other surface residues shows that, on average, the interface is more rigid than the rest of the protein surface and Gly, Ala, Ser, Cys, Leu, and Trp have a propensity to form more stable docking patches on the interface. The findings have broad implications for understanding mechanisms of protein association and stability of protein structures.

Fluctuation Theorem for Many-Body Pure Quantum States.

PubMed

Iyoda, Eiki; Kaneko, Kazuya; Sagawa, Takahiro

2017-09-08

We prove the second law of thermodynamics and the nonequilibrium fluctuation theorem for pure quantum states. The entire system obeys reversible unitary dynamics, where the initial state of the heat bath is not the canonical distribution but is a single energy eigenstate that satisfies the eigenstate-thermalization hypothesis. Our result is mathematically rigorous and based on the Lieb-Robinson bound, which gives the upper bound of the velocity of information propagation in many-body quantum systems. The entanglement entropy of a subsystem is shown connected to thermodynamic heat, highlighting the foundation of the information-thermodynamics link. We confirmed our theory by numerical simulation of hard-core bosons, and observed dynamical crossover from thermal fluctuations to bare quantum fluctuations. Our result reveals a universal scenario that the second law emerges from quantum mechanics, and can be experimentally tested by artificial isolated quantum systems such as ultracold atoms.

Elastically driven intermittent microscopic dynamics in soft solids

NASA Astrophysics Data System (ADS)

Bouzid, Mehdi; Colombo, Jader; Barbosa, Lucas Vieira; Del Gado, Emanuela

2017-06-01

Soft solids with tunable mechanical response are at the core of new material technologies, but a crucial limit for applications is their progressive aging over time, which dramatically affects their functionalities. The generally accepted paradigm is that such aging is gradual and its origin is in slower than exponential microscopic dynamics, akin to the ones in supercooled liquids or glasses. Nevertheless, time- and space-resolved measurements have provided contrasting evidence: dynamics faster than exponential, intermittency and abrupt structural changes. Here we use 3D computer simulations of a microscopic model to reveal that the timescales governing stress relaxation, respectively, through thermal fluctuations and elastic recovery are key for the aging dynamics. When thermal fluctuations are too weak, stress heterogeneities frozen-in upon solidification can still partially relax through elastically driven fluctuations. Such fluctuations are intermittent, because of strong correlations that persist over the timescale of experiments or simulations, leading to faster than exponential dynamics.

Fluctuation Theorem for Many-Body Pure Quantum States

NASA Astrophysics Data System (ADS)

Iyoda, Eiki; Kaneko, Kazuya; Sagawa, Takahiro

2017-09-01

We prove the second law of thermodynamics and the nonequilibrium fluctuation theorem for pure quantum states. The entire system obeys reversible unitary dynamics, where the initial state of the heat bath is not the canonical distribution but is a single energy eigenstate that satisfies the eigenstate-thermalization hypothesis. Our result is mathematically rigorous and based on the Lieb-Robinson bound, which gives the upper bound of the velocity of information propagation in many-body quantum systems. The entanglement entropy of a subsystem is shown connected to thermodynamic heat, highlighting the foundation of the information-thermodynamics link. We confirmed our theory by numerical simulation of hard-core bosons, and observed dynamical crossover from thermal fluctuations to bare quantum fluctuations. Our result reveals a universal scenario that the second law emerges from quantum mechanics, and can be experimentally tested by artificial isolated quantum systems such as ultracold atoms.

Dynamic Temperature and Pressure Measurements in the Core of a Propulsion Engine

NASA Technical Reports Server (NTRS)

Schuster, Bill; Gordon, Grant; Hultgren, Lennart S.

2015-01-01

Dynamic temperature and pressure measurements were made in the core of a TECH977 propulsion engine as part of a NASA funded investigation into indirect combustion noise. Dynamic temperature measurements were made in the combustor, the inter-turbine duct, and the mixer using ten two-wire thermocouple probes. Internal dynamic pressure measurements were made at the same locations using piezoresistive transducers installed in semi-infinite coils. Measurements were acquired at four steady state operating conditions covering the range of aircraft approach power settings. Fluctuating gas temperature spectra were computed from the thermocouple probe voltage measurements using a compensation procedure that was developed under previous NASA test programs. A database of simultaneously acquired dynamic temperature and dynamic pressure measurements was produced. Spectral and cross-spectral analyses were conducted to explore the characteristics of the temperature and pressure fluctuations inside the engine, with a particular focus on attempting to identify the presence of indirect combustion noise.

Refractometric sensitivity and thermal stabilization of fluorescent core microcapillary sensors: theory and experiment.

PubMed

Lane, S; Marsiglio, F; Zhi, Y; Meldrum, A

2015-02-20

Fluorescent-core microcapillaries (FCMs) present a robust basis for the application of optical whispering gallery modes toward refractometric sensing. An important question concerns whether these devices can be rendered insensitive to local temperature fluctuations, which may otherwise limit their refractometric detection limits, mainly as a result of thermorefractive effects. Here, we first use a standard cylindrical cavity formalism to develop the refractometric and thermally limited detection limits for the FCM structure. We then measure the thermal response of a real device with different analytes in the channel and compare the result to the theory. Good stability against temperature fluctuations was obtained for an ethanol solvent, with a near-zero observed thermal shift for the transverse magnetic modes. Similarly good results could in principle be obtained for any other solvent (e.g., water), if the thickness of the fluorescent layer can be sufficiently well controlled.

Properties of 10 (18)-10 (19)eV EAS at far core distance

NASA Technical Reports Server (NTRS)

Teshima, M.; Nagano, M.; Hara, T.; Hatano, Y.; Hayashida, N.; He, C. X.; Honda, M.; Ishikawa, F.; Kamata, K.; Matsubara, Y.

1985-01-01

The properties of 10 to the 18th power - 10 to the 19th power eV EAS showers such as the electron lateral distribution, the muon lateral distribution ( 1Gev), the ratio of muon density to a electron density, the shower front structure and the transition effects in scintillator of 5cm thickness are investigated with the Akeno 4 sq km/20sq km array at far core distances between 500m and 3000m. The fluctuation of densities and arrival time increase rapidly at core distances greater than 2km.

Spontaneous Brain Activity Did Not Show the Effect of Violent Video Games on Aggression: A Resting-State fMRI Study.

PubMed

Pan, Wei; Gao, Xuemei; Shi, Shuo; Liu, Fuqu; Li, Chao

2017-01-01

A great many of empirical researches have proved that longtime exposure to violent video game can lead to a series of negative effects. Although research has focused on the neural basis of the correlation between violent video game and aggression, little is known whether the spontaneous brain activity is associated with violent video game exposure. To address this question, we measured the spontaneous brain activity using resting-state functional magnetic resonance imaging (fMRI). We used the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) to quantify spontaneous brain activity. The results showed there is no significant difference in ALFF, or fALFF, between violent video game group and the control part, indicating that long time exposure to violent video games won't significantly influence spontaneous brain activity, especially the core brain regions such as execution control, moral judgment and short-term memory. This implies the adverse impact of violent video games is exaggerated.

Spontaneous Brain Activity Did Not Show the Effect of Violent Video Games on Aggression: A Resting-State fMRI Study

PubMed Central

Pan, Wei; Gao, Xuemei; Shi, Shuo; Liu, Fuqu; Li, Chao

2018-01-01

A great many of empirical researches have proved that longtime exposure to violent video game can lead to a series of negative effects. Although research has focused on the neural basis of the correlation between violent video game and aggression, little is known whether the spontaneous brain activity is associated with violent video game exposure. To address this question, we measured the spontaneous brain activity using resting-state functional magnetic resonance imaging (fMRI). We used the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) to quantify spontaneous brain activity. The results showed there is no significant difference in ALFF, or fALFF, between violent video game group and the control part, indicating that long time exposure to violent video games won’t significantly influence spontaneous brain activity, especially the core brain regions such as execution control, moral judgment and short-term memory. This implies the adverse impact of violent video games is exaggerated. PMID:29375416

Temperature-Robust Neural Function from Activity-Dependent Ion Channel Regulation.

PubMed

O'Leary, Timothy; Marder, Eve

2016-11-07

Many species of cold-blooded animals experience substantial and rapid fluctuations in body temperature. Because biological processes are differentially temperature dependent, it is difficult to understand how physiological processes in such animals can be temperature robust [1-8]. Experiments have shown that core neural circuits, such as the pyloric circuit of the crab stomatogastric ganglion (STG), exhibit robust neural activity in spite of large (20°C) temperature fluctuations [3, 5, 7, 8]. This robustness is surprising because (1) each neuron has many different kinds of ion channels with different temperature dependencies (Q 10 s) that interact in a highly nonlinear way to produce firing patterns and (2) across animals there is substantial variability in conductance densities that nonetheless produce almost identical firing properties. The high variability in conductance densities in these neurons [9, 10] appears to contradict the possibility that robustness is achieved through precise tuning of key temperature-dependent processes. In this paper, we develop a theoretical explanation for how temperature robustness can emerge from a simple regulatory control mechanism that is compatible with highly variable conductance densities [11-13]. The resulting model suggests a general mechanism for how nervous systems and excitable tissues can exploit degenerate relationships among temperature-sensitive processes to achieve robust function. Copyright © 2016 Elsevier Ltd. All rights reserved.

Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct

PubMed Central

Bradshaw, J; Saling, M; Hopwood, M; Anderson, V; Brodtmann, A

2004-01-01

Objectives: To document and illustrate qualitative features of fluctuating cognition as described by care givers of patients with probable dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). To determine whether the quality of the fluctuations differs between DLB and AD. To examine the clinical utility of two recently developed rating scales. Methods: Care givers of 13 patients with early probable DLB and 12 patients with early probable AD were interviewed using the Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale, both developed recently. Descriptions of fluctuating cognition were recorded verbatim, analysed, and rated. Results: Descriptions of fluctuating cognition in DLB had a spontaneous, periodic, transient quality, which appeared to reflect an interruption in the ongoing flow of awareness or attention that impacted on functional abilities. Descriptions of fluctuations in AD frequently highlighted episodes of memory failure, or a more enduring state shift in the form of "good" and "bad" days, typically occurring in response to the cognitive demands of the immediate environment. These qualitative differences could be detected reliably by independent raters, but were not always captured in standard severity scores. Conclusion: Fluctuations occuring in DLB have particular characteristics that are distinguishable from fluctuations occurring in AD. Interpretation and application of the fluctuation criterion continues to limit the diagnostic sensitivity of the consensus criteria for DLB. Findings suggest that explicit documentation and a wider appreciation of these distinctions could improve the reliability with which less experienced clinicians identify this core diagnostic feature in the clinical setting. PMID:14966152

Simultaneous in vivo recording of local brain temperature and electrophysiological signals with a novel neural probe

NASA Astrophysics Data System (ADS)

Fekete, Z.; Csernai, M.; Kocsis, K.; Horváth, Á. C.; Pongrácz, A.; Barthó, P.

2017-06-01

Objective. Temperature is an important factor for neural function both in normal and pathological states, nevertheless, simultaneous monitoring of local brain temperature and neuronal activity has not yet been undertaken. Approach. In our work, we propose an implantable, calibrated multimodal biosensor that facilitates the complex investigation of thermal changes in both cortical and deep brain regions, which records multiunit activity of neuronal populations in mice. The fabricated neural probe contains four electrical recording sites and a platinum temperature sensor filament integrated on the same probe shaft within a distance of 30 µm from the closest recording site. The feasibility of the simultaneous functionality is presented in in vivo studies. The probe was tested in the thalamus of anesthetized mice while manipulating the core temperature of the animals. Main results. We obtained multiunit and local field recordings along with measurement of local brain temperature with accuracy of 0.14 °C. Brain temperature generally followed core body temperature, but also showed superimposed fluctuations corresponding to epochs of increased local neural activity. With the application of higher currents, we increased the local temperature by several degrees without observable tissue damage between 34-39 °C. Significance. The proposed multifunctional tool is envisioned to broaden our knowledge on the role of the thermal modulation of neuronal activity in both cortical and deeper brain regions.

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions.

PubMed

Spiess, Matthias; Hernandez-Varas, Pablo; Oddone, Anna; Olofsson, Helene; Blom, Hans; Waithe, Dominic; Lock, John G; Lakadamyali, Melike; Strömblad, Staffan

2018-06-04

Integrins are the core constituents of cell-matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactive conformations, yet whether the activity state influences the spatial organization of integrins within FAs has remained unclear. In this study, we address this question and also ask whether integrin activity may be regulated either independently for each integrin molecule or through locally coordinated mechanisms. We used two distinct superresolution microscopy techniques, stochastic optical reconstruction microscopy (STORM) and stimulated emission depletion microscopy (STED), to visualize active versus inactive β1 integrins. We first reveal a spatial hierarchy of integrin organization with integrin molecules arranged in nanoclusters, which align to form linear substructures that in turn build FAs. Remarkably, within FAs, active and inactive β1 integrins segregate into distinct nanoclusters, with active integrin nanoclusters being more organized. This unexpected segregation indicates synchronization of integrin activities within nanoclusters, implying the existence of a coordinate mechanism of integrin activity regulation. © 2018 Spiess et al.

Role of density gradient driven trapped electron mode turbulence in the H-mode inner core with electron heating

DOE PAGES

Ernst, D. R.; Burrell, K. H.; Guttenfelder, W.; ...

2016-05-10

In a series of DIII-D [J. L. Luxon, Nucl. Fusion 42 614 (2002)] low torque quiescent H-mode experiments show that density gradient driven TEM (DGTEM) turbulence dominates the inner core of H-Mode plasmas during strong electron cyclotron heating (ECH). By adding 3.4 MW ECH doubles T e/T i from 0.5 to 1.0, which halves the linear DGTEM critical density gradient, locally reducing density peaking, while transport in all channels displays extreme stiffness in the density gradient. This then suggests fusion -heating may degrade inner core confinement in H-Mode plasmas with moderate density peaking and low collisionality, with equal electron andmore » ion temperatures, key conditions expected in burning plasmas. Gyrokinetic simulations using GYRO [J. Candy and R. E. Waltz, J. Comp. Phys. 186 545 (2003)] (and GENE [F. Jenko et al., Phys. Plasmas 7, 1904 (2000)]) closely match not only particle, energy, and momentum fluxes, but also density fluctuation spectra from Doppler Backscattering (DBS), with and without ECH. Inner core DBS density fluctuations display discrete frequencies with adjacent toroidal mode numbers, which we identify as DGTEMs. GS2 [W. Dorland et al., Phys. Rev. Lett. 85 5579 (2000)] predictions show the DGTEM can be suppressed, to avoid degradation with electron heating, by broadening the current density profile to attain q 0 > q min > 1.« less

Valence charge fluctuations in YBa/sub 2/Cu/sub 3/O/sub 7-//sub delta/ from core-level spectroscopies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balzarotti, A.; De Crescenzi, M.; Motta, N.

1988-10-01

From x-ray photoemission and Auger measurements of the Cu 2p and O 1s core levels of YBa/sub 2/Cu/sub 3/O/sub 7-//sub delta/ as a function of the oxygen concentration delta, the average copper charge is determined. Evidence is found of dynamic charge fluctuations on the oxygen sublattice giving rise to a greater concentration of trivalent copper at the Cu(1) sites with respect to that determined by the analysis of neutron-diffraction data. On the basis of our experimental results, we introduce a molecular cluster description for the Cu states. The lowest final-states configurations of Cu/sup 2+/ and Cu/sup 3+/ are c3d/sup 10/Lmore » and c3d/sup 10/L/sup 2/, respectively, where c and L denote core holes on copper and oxygen atoms. Oxygen holes have high mobility and a Hubbard correlation energy less than 2 eV, a signature of their delocalization. The effect of temperature on the spectra is minor. Surface degradation modifies the relative intensity of the structures, particularly those of the O spectrum.« less

Cross-separatrix Coupling in Nonlinear Global Electrostatic Turbulent Transport in C-2U

NASA Astrophysics Data System (ADS)

Lau, Calvin; Fulton, Daniel; Bao, Jian; Lin, Zhihong; Binderbauer, Michl; Tajima, Toshiki; Schmitz, Lothar; TAE Team

2017-10-01

In recent years, the progress of the C-2/C-2U advanced beam-driven field-reversed configuration (FRC) experiments at Tri Alpha Energy, Inc. has pushed FRCs to transport limited regimes. Understanding particle and energy transport is a vital step towards an FRC reactor, and two particle-in-cell microturbulence codes, the Gyrokinetic Toroidal Code (GTC) and A New Code (ANC), are being developed and applied toward this goal. Previous local electrostatic GTC simulations find the core to be robustly stable with drift-wave instability only in the scrape-off layer (SOL) region. However, experimental measurements showed fluctuations in both regions; one possibility is that fluctuations in the core originate from the SOL, suggesting the need for non-local simulations with cross-separatrix coupling. Current global ANC simulations with gyrokinetic ions and adiabatic electrons find that non-local effects (1) modify linear growth-rates and frequencies of instabilities and (2) allow instability to move from the unstable SOL to the linearly stable core. Nonlinear spreading is also seen prior to mode saturation. We also report on the progress of the first turbulence simulations in the SOL. This work is supported by the Norman Rostoker Fellowship.

Turbulence and transport in high density, increased β LAPD plasmas

NASA Astrophysics Data System (ADS)

Rossi, Giovanni; Carter, Troy; Guice, Danny

2014-10-01

A new LaB6 cathode plasma source has recently been deployed on the Large Plasma Device (LAPD), allowing for the production of significantly higher plasma density (ne ~ 3 ×1013 cm-3) and temperature (Te ~ 12 eV and Ti ~ 6 eV). This source produces a smaller core plasma (~20cm diameter) that can be embedded in the lower temperature, lower density standard LAPD plasma (60 cm diameter, 1012 cm-3, Te ~ 5 eV, Ti ~ 1 eV). We will present first results from experiments exploring the nature of turbulence and transport produced by this high density core plasma. In contrast to the edge of the standard LAPD plasma, coherent fluctuations are observed in the edge of the high density core plasma. These coherent modes are dominant at low field (~400 G) with a transition to a more broadband spectrum at higher fields (~1 kG). The combination of increased density and temperature with lowered field in LAPD leads to significant increases in plasma β (in fact β ~ 1 can be achieved for B ~ 100 G). As the field is lowered, the strength of correlated magnetic fluctuations increases substantially.

Feasibility of detecting aircraft wake vortices using passive microwave radiometers

NASA Technical Reports Server (NTRS)

Harrington, Richard F.

1993-01-01

The feasibility of detecting the cold core of the wake vortex from the wingtips of an aircraft using a passive microwave radiometer was investigated. It was determined that there is a possibility that a cold core whose physical temperature drop is 10 C or greater and which has a diameter of 5 m or greater can be detected by a microwave radiometer. The radiometer would be a noise injection balanced Dicke radiometer operating at a center frequency of 60 GHz. It would require a noise figure of 5 dB, a predetection bandwidth of 6 GHz, and an integration time of 2 seconds resulting in a radiometric sensitivity of 0.018 K. However, three additional studies are required. The first would determine what are the fluctuations in the radiometric antenna temperature due to short-term fluctuations in atmospheric pressure, temperature, and relative humidity. Second, what is the effect of the pressure and temperature drop within the cold core of the wake vortex on its opacity. The third area concerns the possibility of developing a 60 GHz radiometer with a radio metric sensitivity an order of magnitude improvement over the existing state of the art.

Melting of Iron to 290 Gigapascals

NASA Astrophysics Data System (ADS)

Sinmyo, R.; Hirose, K.; Ohishi, Y.

2017-12-01

The Earth's core is composed mainly of iron. Since liquid core coexists with solid core at the inner core boundary (ICB), the melting point of iron at 330 gigapascals offers a key constraint on core temperatures. However, previous results using a laser-heated diamond-anvil cell (DAC) have been largely inconsistent with each other, likely because of an intrinsic large temperature gradient and its temporal fluctuation. Here we employed an internal-resistance-heated DAC and determined the melting temperature of pure iron up to 290 gigapascals, the highest ever in static compression experiments. A small extrapolation indicates a melting point of 5500 ± 80 kelvin at the ICB, about 500-1000 degrees lower than earlier shock-compression data. It suggests a relatively low temperature for the core-mantle boundary, which avoids global melting of the lowermost mantle in the last more than 1.5 billion years.

Extraction of natural weight shift and foot rolling in gait based on hetero-core optical fiber load sensor

NASA Astrophysics Data System (ADS)

Otsuka, Yudai; Koyama, Yuya; Nishiyama, Michiko; Watanabe, Kazuhiro

2016-03-01

Gait in daily activity affects human health because it may cause physical problems such as asymmetric pelvis, flat foot and bowlegs. Monitoring natural weight shift and foot rolling on plantar has been employed in order for researchers to analyze gait characteristics. Conventional gait monitoring systems have been developed using camera, acceleration sensor, gyro sensor and electrical load sensors. They have some problems such as limited measurement place, temperature dependence and electric leakage. On the other hand, a hetero-core optical fiber sensor has many advantages such as high sensitivity for macro-bending, light weight sensor element, independency on temperature fluctuations, and no electric contact. This paper describes extraction of natural weight shift and foot rolling for gait evaluation by using a sensitive shoe, in the insole of which hetero-core optical load sensors are embedded for detecting plantar pressure. Plantar pressure of three subjects who wear the sensitive shoe and walk on the treadmill was monitored. As a result, weight shift and foot rolling for three subjects were extracted using the proposed sensitive shoe in terms of centroid movement and positions. Additionally, these extracted data are compared to that of electric load sensor to ensure consistency. For these results, it was successfully demonstrated that hetero-core optical fiber load sensor performed in unconstraint gait monitoring as well as electric load sensor.

Implications of high amplitude atmospheric CO2 fluctuations on past millennium climate change

NASA Astrophysics Data System (ADS)

van Hoof, Thomas; Kouwenberg, Lenny; Wagner-Cremer, Friederike; Visscher, Henk

2010-05-01

Stomatal frequency analysis of leaves of land plants preserved in peat and lake deposits can provide a proxy record of pre-industrial atmospheric CO2 concentration complementary to measurements in Antarctic ice cores. Stomatal frequency based CO2 trends from the USA and NW European support the presence of significant CO2 variability during the first half of the last millennium (Kouwenberg et al., 2005; Wagner et al., 2004; van Hoof et al., 2008). The timing of the most significant perturbation in the stomata records (1200 AD) is in agreement with an observed CO2 fluctuation in the D47 Antarctic ice-core record (Barnola et al., 1995; van Hoof et al., 2005). The amplitude of the stomatal frequency based CO2 changes (> 34ppmv) exceeds the maximum amplitude of CO2 variability in the D47 ice core (< 10 ppmv). A modelling experiment taking into account firn-densification based smoothing processes in the D47 ice core proved, however, that the amplitude difference between the stomata record and the D47 ice-core can be explained by natural smoothing processes in the ice (van Hoof et al., 2005). This observation gives credence to the existence of high-amplitude CO2 fluctuations during the last millennium and suggests that high resolution ice core CO2 records should be regarded as a smoothed representation of the atmospheric CO2 signal. In the present study, potential marine and terrestrial sources and sinks associated with the observed atmospheric CO2 perturbation will be discussed. The magnitude of the observed CO2 variability implies that inferred changes in CO2 radiative forcing are of a similar magnitude as variations ascribed to other forcing mechanisms (e.g. solar forcing and volcanism), therefore challenging the IPCC concept of CO2 as an insignificant preindustrial climate forcing factor. References Barnola J.M., M. Anklin, J. Porcheron, D. Raynaud, J. Schwander and B. Stauffer 1995. CO2 evolution during the last millennium as recorded by Antarctic and Greenland ice. Tellus, v 47B, p. 264-272 Kouwenberg L.L.R., F. Wagner, W.M. Kürschner and H. Visscher 2005. Atmospheric CO2 fluctuations during the last Millennium reconstructed by stomatal frequency analysis of Tsuga heterophylla needles. Geology, v. 33, no.1, pp. 33-36 van Hoof T.B., K.A. Kaspers, F. Wagner, R.S.W. van de Wal, W.M. Kürschner and H. Visscher 2005. Atmospheric CO2 during the 13th century AD: reconciliation of data from ice core measurements and stomatal frequency analysis. Tellus B, v. 57, pp. 351-355 van Hoof T.B., F. Wagner-Cremer, W.M. K Kürschner and H. Visscher 2008. A role for atmospheric CO2 in preindustrial climate forcing. Proceedings of the National Academy of Sciences of the USA, v. 105, no. 41, pp. 15815-15818 Wagner F., L.L.R. Kouwenberg, T.B. van Hoof and H. Visscher 2004. Reproducibility of Holocene atmospheric CO2 records based on stomatal frequency. Quartenary Science Reviews. V. 23, pp. 1947-1954

Paleoproductivity evolution in the West Philippine Sea during the last 700 ka

NASA Astrophysics Data System (ADS)

Tang, Zheng; Li, Tiegang; Chang, Fengming; Nan, Qingyun; Li, Qing

2013-03-01

In order to reconstruct the paleoproductivity evolution history of the West Philippine Sea during the last 700 ka, the vertical gradient of Δδ13C in dissolved inorganic carbon (Δδ13C between those of foraminifera Pulleniatina obliquiloculata and Cibicidoides wuellerstorfi) and planktonic foraminiferal assemblages were analysed in piston Core MD06-3047 retrieved from the Benham Rise (east of the Luzon Island). Paleoproductivity evolution in the West Philippine Sea during the last 700 ka is closely related to glacial-interglacial cycles and precession-controlled insolation. Controlling factors of paleoproductivity could have been both thermocline fluctuations related with ENSO-like processes and eolian input associated with East Asian winter monsoon, and the former could have been the primary factor. A higher productivity and a shallower thermocline coeval with the occurrence of low CO2 concentrations in the EPICA Dome C ice core might indicate that biological export production in the low-latitude could act as a significant sink in the global carbon cycle, and modify atmospheric CO2 concentrations. Spectral analysis further reveals that the paleoproductivity is mainly controlled by thermocline fluctuations subjected to ENSO processes responding to processional variability of insolation. High coherences in eccentricity, obliquity and precession periods further revealing the close link between thermocline fluctuations, paleoproductivity and atmospheric CO2 levels.

Solar Forced Dansgaard/Oeschger Events?

NASA Technical Reports Server (NTRS)

Muscheler, R.; Beer, J.

2006-01-01

Climate records for the last ice age (which ended 11,500 years ago) show enormous climate fluctuations in the North Atlantic region - the so-called Dansgaard/Oeschger events. During these events air temperatures in Greenland changed on the order of 10 degrees Celsius within a few decades. These changes were attributed to shifts in ocean circulation which influences the warm water supply from lower latitudes to the North Atlantic region. Interestingly, the rapid warmings tend to recur approximately every 1500 years or multiples thereof. This has led researchers to speculate about an external cause for these changes with the variable Sun being one possible candidate. Support for this hypothesis came from climate reconstructions, which suggested that the Sun influenced the climate in the North Atlantic region on these time scales during the last approximately 12,000 years of relatively stable Holocene climate. However, Be-10 measurements in ice cores do not indicate that the Sun caused or triggered the Dansgaard/Oeschger events. Depending on the solar magnetic shielding more or less Be-10 is produced in the Earth's atmosphere. Therefore, 10Be can be used as a proxy for solar activity changes. Since Be-10 can be measured in ice cores, it is possible to compare the variable solar forcing directly with the climate record from the same ice core. This removes any uncertainties in the relative dating, and the solar-climate link can be reliably studied. Notwithstanding that some Dansgaard/Oeschger warmings could be related to increased solar activity, there is no indication that this is the case for all of the Dansgaard/Oeschger events. Therefore, during the last ice age the Be-10 and ice core climate data do not indicate a persistent solar influence on North Atlantic climate.

Light scattering from liquid crystal director fluctuations in steady magnetic fields up to 25 tesla.

PubMed

Challa, Pavan K; Curtiss, O; Williams, J C; Twieg, R; Toth, J; McGill, S; Jákli, A; Gleeson, J T; Sprunt, S N

2012-07-01

We report on homodyne dynamic light scattering measurements of orientational fluctuation modes in both calamitic and bent-core nematic liquid crystals, carried out in the new split-helix resistive magnet at the National High Magnetic Field Laboratory. The relaxation rate and inverse scattered intensity of director fluctuations exhibit a linear dependence on field-squared up to 25 tesla, which is consistent with strictly lowest order coupling of the tensor order parameter Q to field (Q(αβ)B(α)B(β)) in the nematic free energy. However, we also observe evidence of field dependence of certain nematic material parameters, an effect which may be expected from the mean field scaling of these quantities with the magnitude of Q and the predicted variation of Q with field.

Investigation of Three-Dimensional Unsteady Flow Characteristics in Transonic Diffusers

NASA Astrophysics Data System (ADS)

Proshchanka, Dzianis; Yonezawa, Koichi; Tsujimoto, Yoshinobu

Three-dimensional characteristics of unsteady flow in supercritical transonic diffuser are investigated. For various pressure ratios three-dimensional flow containing a normal shock/turbulent boundary layer interaction regions with shockwave and pseudo-shockwaves fluctuating in longitudinal and spanwise directions is observed. Experimental and numerical investigations show details of the flowfield in the vicinity of terminal shock, interaction regions and downstream turbulent unsteady flow. Spectral analysis of pressure fluctuations reveals existence of two characteristic frequencies attributed to the shockwave fluctuation in longitudinal direction for the lower frequency case and acoustic resonance in spanwise direction for the higher one. Vortices appear at each corner in transversal sections modifying the core flow. As a result, size and depth of longitudinal and vertical penetration of separation regions impelled by the terminal shock is either increased or decreased.

Application of 3-signal coherence to core noise transmission

NASA Technical Reports Server (NTRS)

Krejsa, E. A.

1983-01-01

A method for determining transfer functions across turbofan engine components and from the engine to the far-field is developed. The method is based on the three-signal coherence technique used previously to obtain far-field core noise levels. This method eliminates the bias error in transfer function measurements due to contamination of measured pressures by nonpropagating pressure fluctuations. Measured transfer functions from the engine to the far-field, across the tailpipe, and across the turbine are presented for three turbofan engines.

Late Holocene vegetation changes in relation with climate fluctuations and human activities in Languedoc (Southern France)

NASA Astrophysics Data System (ADS)

Azuara, J.; Combourieu-Nebout, N.; Lebreton, V.; Mazier, F.; Müller, S. D.; Dezileau, L.

2015-09-01

Holocene climate fluctuations and human activities since the Neolithic have shaped present-day Mediterranean environments. Separating anthropogenic effects from climatic impacts to reconstruct Mediterranean paleoenvironments over the last millennia remains a challenging issue. High resolution pollen analyses were undertaken on two cores from the Palavasian lagoon system (Hérault, southern France). These records allow reconstruction of vegetation dynamics over the last 4500 years. Results are compared with climatic, historical and archeological archives. A long-term aridification trend is highlighted during the Late Holocene and three superimposed arid events are recorded at 4600-4300, 2800-2400 and 1300-1100 cal BP. These periods of climatic instability coincide in time with the rapid climatic events depicted in the Atlantic Ocean (Bond et al., 2001). From the Bronze Age (4000 cal BP) to the end of the Iron Age (around 2000 cal BP), the spread of evergreen taxa and loss of forest cover result from anthropogenic impact. The Antiquity is characterized by a major reforestation event related to the concentration of rural activities and populations in coastal plains leading to forest recovery in the mountains. A major regional deforestation occurred at the beginning of the High Middle Ages. Around 1000 cal BP, forest cover is minimal while cover of olive, chestnut and walnut expands in relation to increasing human influence. The present day vegetation dominated by Mediterranean shrubland and pines has been in existence since the beginning of the 20th century.

Late Holocene vegetation changes in relation with climate fluctuations and human activity in Languedoc (southern France)

NASA Astrophysics Data System (ADS)

Azuara, J.; Combourieu-Nebout, N.; Lebreton, V.; Mazier, F.; Müller, S. D.; Dezileau, L.

2015-12-01

Holocene climate fluctuations and human activity since the Neolithic have shaped present-day Mediterranean environments. Separating anthropogenic effects from climatic impacts to better understand Mediterranean paleoenvironmental changes over the last millennia remains a challenging issue. High-resolution pollen analyses were undertaken on two cores from the Palavasian lagoon system (Hérault, southern France). These records allow reconstruction of vegetation dynamics over the last 4500 years. Results are compared with climatic, historical and archeological archives. A long-term aridification trend is highlighted during the late Holocene, and three superimposed arid events are recorded at 4600-4300, 2800-2400 and 1300-1100 cal BP. These periods of high-frequency climate variability coincide in time with the rapid climatic events observed in the Atlantic Ocean (Bond et al., 2001). From the Bronze Age (4000 cal BP) to the end of the Iron Age (around 2000 cal BP), the spread of sclerophyllous taxa and loss of forest cover result from anthropogenic impact. Classical Antiquity is characterized by a major reforestation event related to the concentration of rural activity and populations in coastal plains leading to forest recovery in the mountains. A major regional deforestation occurred at the beginning of the High Middle Ages. Around 1000 cal BP, forest cover is minimal while the cover of olive, chestnut and walnut expands in relation to increasing human influence. The present-day vegetation dominated by Mediterranean shrubland and pines has been in existence since the beginning of the 20th century.

A Multi-proxy Approach to Understanding the Diagenesis of Carbonates in Pennsylvanian Mudrocks in the Midland Basin

NASA Astrophysics Data System (ADS)

Reis, A.; McGlue, M. M.; Waite, L.; Erhardt, A. M.

2017-12-01

Diagenetic processes influenced by changing climate, eustatic fluctuations, and porewater evolution led to the formation and alteration of carbonate layers in the Pennsylvanian Wolfcamp D Formation of the Midland Basin. Preliminary evidence from bulk geochemistry, oxygen and carbon stable isotopes, and petrographic analysis of the carbonates recovered from two drill cores indicate multiple generations of diagenesis. High Mg calcite and dolomite layers predominantly occur in the fine grained intervals of both cores. Whereas there are less carbonate layers in the central basin core, more of the layers underwent diagenesis compared to the carbonates in the southern core. δ13CPDB values ranging from -6‰ to -4‰ and the presence of framboidal pyrite indicate initial dolomite precipitation occurring in the zone of bacterial sulfate reduction. Later stages alteration occurred following the burial diagenesis of clay, releasing Mg2+ and Fe2+ into the pore waters allowing ferroan dolomite rims to precipitate on the precursor iron-poor dolomite rhombs. δ13CPDB and δ18OPDBvalues from altered beds in the southern core show a positive 4-6‰ offset from the central basin beds. Petrographic analysis of the carbonate intervals shows a larger allochem size, and lower pyrite abundance in the southern core. These differences can be associated with a shorter source-to-sink distance and less frequent bottom water anoxia, leading to reduced rates of sulfate reduction. One possibility we will explore is if increased circulation due to the proximity of the southern core to the Sheffield Channel could stabilize the bottom water conditions in this region of the basin. In addition to dolomite precipitation and replacement, scanning electron microscopy reveals the replacement of silica cements by calcite, suggesting an increase in porewater pH during or following sulfate reduction coinciding with pyrite formation. Changing bottom water chemistry tied to fluctuations in sea-level through time led to porewater conditions favorable to several generations of post-depositional diagenesis.

Revised Model of the Steady-state Solar Wind Halo Electron Velocity Distribution Function

NASA Astrophysics Data System (ADS)

Yoon, Peter H.; Kim, Sunjung; Choe, G. S.; moon, Y.-J.

2016-08-01

A recent study discussed the steady-state model for solar wind electrons during quiet time conditions. The electrons emanating from the Sun are treated in a composite three-population model—the low-energy Maxwellian core with an energy range of tens of eV, the intermediate ˜102-103 eV energy-range (“halo”) electrons, and the high ˜103-105 eV energy-range (“super-halo”) electrons. In the model, the intermediate energy halo electrons are assumed to be in resonance with transverse EM fluctuations in the whistler frequency range (˜102 Hz), while the high-energy super-halo electrons are presumed to be in steady-state wave-particle resonance with higher-frequency electrostatic fluctuations in the Langmuir frequency range (˜105 Hz). A comparison with STEREO and WIND spacecraft data was also made. However, ignoring the influence of Langmuir fluctuations on the halo population turns out to be an unjustifiable assumption. The present paper rectifies the previous approach by including both Langmuir and whistler fluctuations in the construction of the steady-state velocity distribution function for the halo population, and demonstrates that the role of whistler-range fluctuation is minimal unless the fluctuation intensity is arbitrarily raised. This implies that the Langmuir-range fluctuations, known as the quasi thermal noise, are important for both halo and super-halo electron velocity distribution.

An effective model of DNA like helicoidal structure: with length fluctuation nonlinearity

NASA Astrophysics Data System (ADS)

Tseytlin, Y. M.

2011-03-01

One of the natural helicoidal nanostructure, which thermomechanical features are studied carefully with the help of different mechanical models, is a DNA cell / molecule. Our study proves that the experimentally determined nonlinear fluctuations of the molecular length of DNA can be better understood by modeling the molecule as a helicoidal pretwisted nanostrip sensor with nonlinear function. The calculations presented here are in good agreement with the experimental data within 10%. Other used by many researchers mechanical models such as an elastic rod, wormlike chain (WLC), accordion bellows, or an elastic core wrapped with rigid wires do not show the possible variance nonlinearity of thermomechanical DNA molecular length fluctuations. We have found that the nonlinear variance of the length fluctuations is an intrinsic property of the micro-nano-sensors with helicoidal shape. This model allows us to estimate the persistence length and twist-stretch coupling of a DNA molecule as well. It also shows the molecule's overwinding possibility at initial stretching with correct numerical representation.

Study of ion-gyroscale fluctuations in low-density L-mode plasmas heated by NBI on KSTAR

NASA Astrophysics Data System (ADS)

Lee, W.; Ko, S. H.; Leem, J.; Yun, G. S.; Park, H. K.; Wang, W. X.; Budny, R. V.; Kim, K. W.; Luhmann, N. C., Jr.; The KSTAR Team

2018-04-01

Broadband density fluctuations with peak frequency ranging from 150 to 400 kHz were measured using a multichannel microwave imaging reflectometer in core region of the low-density L-mode plasmas heated by neutral beam injection on KSTAR. These fluctuations have been studied by comparing the dominant mode scales estimated from the measurement with those predicted from linear gyrokinetic simulation. The measured poloidal wavenumbers are qualitatively comparable to those of the ‘fastest growing modes’ from simulations, whereas they are larger than those of the ‘transport-dominant modes’ by about a factor of three. The agreement on wavenumbers between the measurement and linear simulation (for the fastest growing modes) is probably due to sufficiently weak E × B flow shear compared to the maximum linear growth rate. Meanwhile, the transport-dominant modes seem to be related to the fluctuations in lower frequencies (˜80-150 kHz) observed in some of the measurement.

Observation of trapped-electron-mode microturbulence in reversed field pinch plasmas

NASA Astrophysics Data System (ADS)

Duff, J. R.; Williams, Z. R.; Brower, D. L.; Chapman, B. E.; Ding, W. X.; Pueschel, M. J.; Sarff, J. S.; Terry, P. W.

2018-01-01

Density fluctuations in the large-density-gradient region of improved confinement Madison Symmetric Torus reversed field pinch (RFP) plasmas exhibit multiple features that are characteristic of the trapped-electron mode (TEM). Core transport in conventional RFP plasmas is governed by magnetic stochasticity stemming from multiple long-wavelength tearing modes. Using inductive current profile control, these tearing modes are reduced, and global confinement is increased to that expected for comparable tokamak plasmas. Under these conditions, new short-wavelength fluctuations distinct from global tearing modes appear in the spectrum at a frequency of f ˜ 50 kHz, which have normalized perpendicular wavenumbers k⊥ρs≲ 0.2 and propagate in the electron diamagnetic drift direction. They exhibit a critical-gradient threshold, and the fluctuation amplitude increases with the local electron density gradient. These characteristics are consistent with predictions from gyrokinetic analysis using the Gene code, including increased TEM turbulence and transport from the interaction of remnant tearing magnetic fluctuations and zonal flow.

Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates.

PubMed

Daigh, Leighton H; Liu, Chad; Chung, Mingyu; Cimprich, Karlene A; Meyer, Tobias

2018-06-04

Faithful DNA replication is challenged by stalling of replication forks during S phase. Replication stress is further increased in cancer cells or in response to genotoxic insults. Using live single-cell image analysis, we found that CDK2 activity fluctuates throughout an unperturbed S phase. We show that CDK2 fluctuations result from transient ATR signals triggered by stochastic replication stress events. In turn, fluctuating endogenous CDK2 activity causes corresponding decreases and increases in DNA synthesis rates, linking changes in stochastic replication stress to fluctuating global DNA replication rates throughout S phase. Moreover, cells that re-enter the cell cycle after mitogen stimulation have increased CDK2 fluctuations and prolonged S phase resulting from increased replication stress-induced CDK2 suppression. Thus, our study reveals a dynamic control principle for DNA replication whereby CDK2 activity is suppressed and fluctuates throughout S phase to continually adjust global DNA synthesis rates in response to recurring stochastic replication stress events. Copyright © 2018. Published by Elsevier Inc.

Fluctuation-Driven Neural Dynamics Reproduce Drosophila Locomotor Patterns

PubMed Central

Cruchet, Steeve; Gustafson, Kyle; Benton, Richard; Floreano, Dario

2015-01-01

The neural mechanisms determining the timing of even simple actions, such as when to walk or rest, are largely mysterious. One intriguing, but untested, hypothesis posits a role for ongoing activity fluctuations in neurons of central action selection circuits that drive animal behavior from moment to moment. To examine how fluctuating activity can contribute to action timing, we paired high-resolution measurements of freely walking Drosophila melanogaster with data-driven neural network modeling and dynamical systems analysis. We generated fluctuation-driven network models whose outputs—locomotor bouts—matched those measured from sensory-deprived Drosophila. From these models, we identified those that could also reproduce a second, unrelated dataset: the complex time-course of odor-evoked walking for genetically diverse Drosophila strains. Dynamical models that best reproduced both Drosophila basal and odor-evoked locomotor patterns exhibited specific characteristics. First, ongoing fluctuations were required. In a stochastic resonance-like manner, these fluctuations allowed neural activity to escape stable equilibria and to exceed a threshold for locomotion. Second, odor-induced shifts of equilibria in these models caused a depression in locomotor frequency following olfactory stimulation. Our models predict that activity fluctuations in action selection circuits cause behavioral output to more closely match sensory drive and may therefore enhance navigation in complex sensory environments. Together these data reveal how simple neural dynamics, when coupled with activity fluctuations, can give rise to complex patterns of animal behavior. PMID:26600381

Fluctuation Dynamics Analysis of gp120 Envelope Protein Reveals a Topologically Based Communication Network

PubMed Central

Shrivastava, Indira; LaLonde, Judith M.

2012-01-01

HIV infection is initiated by binding of the viral glycoprotein gp120, to the cellular receptor CD4. Upon CD4 binding, gp120 undergoes conformational change, permitting binding to the chemokine receptor. Crystal structures of gp120 ternary complex reveal the CD4 bound conformation of gp120. We report here the application of Gaussian Network Model (GNM) to the crystal structures of gp120 bound to CD4 or CD4 mimic and 17b, to study the collective motions of the gp120 core and determine the communication propensities of the residue network. The GNM fluctuation profiles identify residues in the inner domain and outer domain that may facilitate conformational change or stability, respectively. Communication propensities delineate a residue network that is topologically suited for signal propagation from the Phe43 cavity throughout the gp120 outer domain. . These results provide a new context for interpreting gp120 core envelope structure-function relationships. PMID:20718047

Implications of Stellar Feedback for Dynamical Modeling of the Milky Way and Dwarf Galaxies

NASA Astrophysics Data System (ADS)

Wetzel, Andrew

2018-04-01

I will present recent results on dynamical modeling of stellar populations from the FIRE cosmological zoom-in baryonic simulations of Milky Way-like and dwarf galaxies. First, I will discuss the dynamical formation of the Milky Way, including the origin of thin+thick stellar disk morphology. I also will discuss the curious origin of metal-rich stars on halo-like orbits near the Sun, as recently measured by Gaia, with new insights from FIRE simulations on stellar radial migration/heating. Next, I will discuss role of stellar feedback in generating non-equilibrium fluctuations of the gravitational potential in low-mass 'dwarf' galaxies, which can explain the origin of cores in their dark-matter density profiles. In particular, we predict significant observable effects on stellar dynamics, including radial migration, size fluctuations, and population gradients, which can provide observational tests of feedback-driven core formation. Finally, this scenario can explain the formation of newly discovered 'ultra-diffuse' galaxies.

Intraoperative fat embolism during core decompression and bone grafting for osteonecrosis of the hip: report of 3 cases and literature review.

PubMed

Schaffer, Joseph Christopher; Adib, Farshad; Cui, Quanjun

2014-06-01

Osteonecrosis (ON) of the femoral head, without timely intervention, often progresses to debilitating hip arthritis. Core decompression (CD) with bone grafting was used to treat patients with early-stage ON. In 3 cases, intraoperative oxygen saturation, end-tidal carbon dioxide fluctuations, and/or vital sign fluctuations were observed during insertion of the graft, a mixture of bone marrow and demineralized bone matrix. In 1 case, continued postoperative pulmonary symptoms required admission to intensive care. In this article, we describe these cases and provide supporting evidence that they were caused by fat emboli secondary to forceful insertion of bone graft. We review the literature and present complications data. Although no cases of fat emboli were reported as complications of any CD series with or without bone grafting, CD augmented with bone graft may carry risks not seen before in CD alone. Care should be taken to avoid these complications, possibly through technique modification.

Electron Thermal Transport due to Magnetic Diffusion in the MST RFP

NASA Astrophysics Data System (ADS)

Reusch, J. A.; Anderson, J. K.; den Hartog, D. J.; Forest, C. B.; Kasten, C. P.; Schnack, D. D.; Stephens, H. D.

2011-10-01

Comparison of measurements made in the MST RFP to the results from extensive nonlinear resistive MHD simulations has provided two key observations. First, trapped particles reduce electron thermal diffusion; inclusion of this effect is required for quantitative agreement of simulation to measurement. Second, the structure and evolution of long-wavelength temperature fluctuations measured in MST shows remarkable qualitative similarity to fluctuations appearing in a finite-pressure simulation. These simulations were run at parameters matching those of 400 kA discharges in MST (S ~ 4 ×106). In a zero β simulation, the measured χe is compared to the thermal diffusion due to parallel losses along diffusing magnetic field lines, χst =v∥Dmag . Agreement is only found if the reduction in χst due to trapped particles is taken into account. In a second simulation, the pressure field was evolved self consistently assuming Ohmic heating and anisotropic thermal conduction. Fluctuations in the simulated temperature are very similar in character and time evolution to temperature fluctuations measured in MST. This includes m = 1 , n = 6 fluctuations that flatten the temperature profile as well as m = 1 , n = 5 fluctuations that generate hot island structures near the core shortly after sawtooth crashes. This work supported by the US DOE and NSF.

Soil Gas Dynamics and Microbial Activity in the Unsaturated Zone of a Regulated River

NASA Astrophysics Data System (ADS)

Christensen, H.; Ferencz, S. B.; Cardenas, M. B.; Neilson, B. T.; Bennett, P. C.

2017-12-01

Over 60% of the world's rivers are dammed, and are therefore regulated. In some river systems, river regulation is the dominant factor governing fluid exchange and soil gas dynamics in the hyporheic region and overlying unsaturated zone of the river banks. Where this is the case, it is important to understand the effects that an artificially-induced change in river stage can have on the chemical, plant, and microbial components of the unsaturated zone. Daily releases from an upstream dam cause rapid stage fluctuations in the Lower Colorado River east of Austin, Texas. For this study, we utilized an array of water and gas wells along a transect perpendicular to the river to investigate the biogeochemical process occurring in this mixing zone. The gas wells were installed at several depths up to 1.5 meters, and facilitated the continuous monitoring of soil gases as the pulse percolated through the river bank. Water samples collected from the screened wells penetrated to depths below the water table and were analyzed for nutrients, carbon, and major ions. Additionally, two soil cores were taken at different distances from the river and analyzed for soil moisture and grain size. These cores were also analyzed for microbial activity using the total heterotroph count method and the acetylene inhibition technique, a sensitive method of measuring denitrifying activity. The results provide a detailed picture of soil gas flux and biogeochemical processes in the bank environment in a regulated river. Findings indicate that a river pulse that causes a meter-scale change in river stage causes small, centimeter-scale pulses in the water table. We propose that these conditions create an area of elevated microbial respiration at the base of the unsaturated zone that appears to be decoupled from normal diurnal fluctuations. Along the transect, CO2 concentrations increased with increasing depth down to the water table. CO2 concentrations were highest in the time following a pulse, and the lowest concentrations were recorded following the trough in river stage.

Mechano-genetic DNA hydrogels as a simple, reconstituted model to probe the effect of active fluctuations on gene transcription

NASA Astrophysics Data System (ADS)

Nguyen, Dan; Saleh, Omar

Active fluctuations - non-directed fluctuations attributable, not to thermal energy, but to non-equilibrium processes - are thought to influence biology by increasing the diffusive motion of biomolecules. Dense DNA regions within cells (i.e. chromatin) are expected to exhibit such phenomena, as they are cross-linked networks that continually experience propagating forces arising from dynamic cellular activity. Additional agitation within these gene-encoding DNA networks could have potential genetic consequences. By changing the local mobility of transcriptional machinery and regulatory proteins towards/from their binding sites, and thereby influencing transcription rates, active fluctuations could prove to be a physical means of modulating gene expression. To begin probing this effect, we construct genetic DNA hydrogels, as a simple, reconstituted model of chromatin, and quantify transcriptional output from these hydrogels in the presence/absence of active fluctuations.

Reconstructed Sediment Mobilization Processes in a Large Reservoir Using Short Sediment Cores

NASA Astrophysics Data System (ADS)

Cockburn, J.; Feist, S.

2014-12-01

Williston Reservoir in northern British Columbia (56°10'31"N, 124°06'33") was formed when the W.A.C. Bennett Dam was created in the late 1960s, is the largest inland body of water in BC and facilitates hydroelectric power generation. Annually the reservoir level rises and lowers with the hydroelectric dam operation, and this combined with the inputs from several river systems (Upper Peace, Finlay, Parsnip, and several smaller creeks) renews suspended sediment sources. Several short-cores retrieved from shallow bays of the Finlay Basin reveal near-annual sedimentary units and distinct patterns related to both hydroclimate variability and the degree to which the reservoir lowered in a particular year. Thin section and sedimentology from short-cores collected in three bays are used to evaluate sediment mobilization processes. The primary sediment sources in each core location is linked to physical inputs from rivers draining into the bays, aeolian contributions, and reworked shoreline deposits as water levels fluctuate. Despite uniform water level lowering across the reservoir, sediment sequences differed at each site, reflecting the local stream inputs. However, distinct organic-rich units, facilitated correlation across the sites. Notable differences in particle size distributions from each core points to important aeolian derived sediment sources. Using these sedimentary records, we can evaluate the processes that contribute to sediment deposition in the basin. This work will contribute to decisions regarding reservoir water levels to reduce adverse impacts on health, economic activities and recreation in the communities along the shores of the reservoir.

Lithologic Coring in the Lower Anacostia Tidal Watershed, Washington, D.C., July 2002

USGS Publications Warehouse

Tenbus, Frederick J.

2003-01-01

Little is known about the volumetric flux of ground water to the lower tidal Anacostia River, or whether ground-water flow is an important component of the contaminant load in this part of the Anacostia River. The watershed is in the eastern part of Washington, D.C., and has been subjected to over 200 years of urbanization and modifications of the river channel and nearby land areas. These anthropogenic factors, along with tidal fluctuations in the river, make ground-water data collection and interpretations difficult. The U.S. Geological Survey is cooperating with the District of Columbia Department of Health, Environmental Health Administration, Bureau of Environmental Quality, Water Quality Division, in a study to assess nonpoint-source pollution from ground water into the lower tidal Anacostia River. Lithologic cores from drilling activities conducted during July 2002 in the study area have been interpreted in the context of geologic and hydrogeologic information from previous studies in the lower Anacostia tidal watershed. These interpretations can help achieve the overall project goals of characterizing ground-water flow and contaminant load in the study area. Hydrostratigraphic units encountered during drilling generally consisted of late Pleistocene to Holocene fluvial deposits overlying Cretaceous fluvial/deltaic deposits. Cores collected in Beaverdam Creek and the Anacostia River indicated high- and low-energy environments of deposition, respectively. Two cores collected near the river showed different types of anthropogenic fill underlain by low-energy deposits, which were in turn underlain by sand and gravel. A third core collected near the river consisted primarily of sand and gravel with no artificial fill.

EPICA Dome C deuterium record of orbital and millennial Antarctic climate variability over the last 800 000 years

NASA Astrophysics Data System (ADS)

Masson-Delmotte, V.

2006-12-01

The detailed deuterium record of the EPICA (European Project for Ice Coring in Antarctica) Dome C ice core from East Antarctica has been measured at a 55 cm resolution down to a depth of 3260 m, covering ~800 000 years. Several lines of evidence support a reliable use of deuterium fluctuations in central Antarctic ice to reconstruct past temperature changes. The magnitude of the temperature fluctuations range between -9°C and +5°C compared to the late Holocene level. At the orbital scale, the imprint of obliquity changes in the EPICA Dome C record is highlighted and compared to simulations conducted with the ECBILT-CLIO intermediate complexity climate model. We discuss the comparison between the current interglacial period and the long interglacial corresponding to marine isotopic stage 11, ~400 kyr BP. Previous studies had focused on the role of precession and the thresholds required to induce glacial inceptions. We suggest that, due to the low eccentricity configuration of MIS 11 and the Holocene, the effect of precession on the incoming solar radiation is damped and that changes in obliquity must be taken into account. The EPICA Dome C alignment of terminations I and V published in 2004 corresponds to a phasing of the obliquity signals. A relationship is observed between an index of interglacial intensity and the cumulative annual mean insolation at high latitudes, mainly as a result of the modulation of amplitude of obliquity fluctuations. We suggest that this long term changes in obliquity may be involved in the change in magnitude of glacial-interglacial fluctuations between the first and second halves of the EPICA Dome C record. At the high frequency scale, the detailed EPICA Dome C deuterium record clearly shows a one-to-one correspondence between each Greenland ice core Dansgaard-Oeschger event and their smoothed Antarctic counterparts. A methodology to detect objectively rapid events from the EPICA Dome C records is developed and applied for the earlier glacial periods, suggesting a stable magnitude and pacing of Antarctic rapid events along the EPICA Dome C record.

Nucleon matter equation of state, particle number fluctuations, and shear viscosity within UrQMD box calculations

NASA Astrophysics Data System (ADS)

Motornenko, A.; Bravina, L.; Gorenstein, M. I.; Magner, A. G.; Zabrodin, E.

2018-03-01

Properties of equilibrated nucleon system are studied within the ultra-relativistic quantum molecular dynamics (UrQMD) transport model. The UrQMD calculations are done within a finite box with periodic boundary conditions. The system achieves thermal equilibrium due to nucleon-nucleon elastic scattering. For the UrQMD-equilibrium state, nucleon energy spectra, equation of state, particle number fluctuations, and shear viscosity η are calculated. The UrQMD results are compared with both, statistical mechanics and Chapman-Enskog kinetic theory, for a classical system of nucleons with hard-core repulsion.

Effect of the fluid core on changes in the length of day due to long period tides

NASA Technical Reports Server (NTRS)

Wahr, J. M.; Smith, M. L.; Sasao, T.

1981-01-01

The long period luni-solar tidal potential is known to cause periodic changes in the earth's rotation rate. It is found that the effect of a dissipationless fluid outer core is to reduce the amplitudes of these tidal perturbations by about 11 percent. When the fluid core effect is added to Agnew and Farrell's (1978) estimate of the effect of an equilibrium ocean, the result is in accord with observation. The effects of dissipative processes within the fluid core are also examined. Out-of-phase perturbations are found which could be as large as about 10 ms at 18.6 yr. It is concluded, however, that the poorly understood decade fluctuations in the earth's rotation rate will prohibit observation of this effect.

Gas hydrate and spatial venting variations in the continental margin offshore Southwestern Taiwan

NASA Astrophysics Data System (ADS)

Lin, S.; Lim, Y.; Hsieh, W.; Yang, T.; Wang, Y.

2006-12-01

Strong BSR, high methane contents and rapid sulfate reduction were found in the continental margin sediments offshore southwestern Taiwan. In order to identify the venting phenomena and its relationship with gas hydrate, this research investigate sea floor vent features using WHOI?|s Towcam system as well as piston core in the study region. A total of 10 dives were conducted on board the r/v OR-1. Pore water sulfate, dissolved sulfide, methane, chloride, del O18 ratio, sediment organic carbon, carbonate content and carbonate del C13 ratio, pyrite-S were measured Large spatial variations were found based on pictures obtained from Towcam system and piston cores. Active venting features include bacteria mat, live dense bivalve patches, gas plume, temperature and salinity fluctuations, rapid sulfate reduction and high concentrations of methane in sediments. In addition, vent chimney, pockmark and large authigenic carbonate buildup were also observed in the active venting area. In contrast, in some areas without active venting features, scatter dead chimney, semi- buried carbonate structures, and dead bivalves were found. Total sulfate depletion was found at depth as shallow as 1 meter below sediment water interface in area near active vent whereas almost no sulfate depletion was observed in areas without any vent feature. Stages of carbonate build up existed, with initial phase dominated by small tube, chimney, and later with massive carbonate structures protruding the sea floor. The appearances of massive carbonate buildup structures seemed to indicate the end stage of gas hydrate venting phenomena.

Motion of Euglena gracilis: Active fluctuations and velocity distribution

NASA Astrophysics Data System (ADS)

Romanczuk, P.; Romensky, M.; Scholz, D.; Lobaskin, V.; Schimansky-Geier, L.

2015-07-01

We study the velocity distribution of unicellular swimming algae Euglena gracilis using optical microscopy and active Brownian particle theory. To characterize a peculiar feature of the experimentally observed distribution at small velocities we use the concept of active fluctuations, which was recently proposed for the description of stochastically self-propelled particles [Romanczuk, P. and Schimansky-Geier, L., Phys. Rev. Lett. 106, 230601 (2011)]. In this concept, the fluctuating forces arise due to internal random performance of the propulsive motor. The fluctuating forces are directed in parallel to the heading direction, in which the propulsion acts. In the theory, we introduce the active motion via the depot model [Schweitzer, et al., Phys. Rev. Lett. 80(23), 5044 (1998)]. We demonstrate that the theoretical predictions based on the depot model with active fluctuations are consistent with the experimentally observed velocity distributions. In addition to the model with additive active noise, we obtain theoretical results for a constant propulsion with multiplicative noise.

Maximum entropy modeling of metabolic networks by constraining growth-rate moments predicts coexistence of phenotypes

NASA Astrophysics Data System (ADS)

De Martino, Daniele

2017-12-01

In this work maximum entropy distributions in the space of steady states of metabolic networks are considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization) and its fluctuations (heterogeneity). This is applied to the carbon catabolic core of Escherichia coli where it quantifies the metabolic activity of slow growing phenotypes and it provides a quantitative map with metabolic fluxes, opening the possibility to detect coexistence from flux data. A preliminary analysis on data for E. coli cultures in standard conditions shows degeneracy for the inferred parameters that extend in the coexistence region.

Luminescence properties of In(Zn)P alloy core/ZnS shell quantum dots

NASA Astrophysics Data System (ADS)

Thuy, Ung Thi Dieu; Reiss, Peter; Liem, Nguyen Quang

2010-11-01

Chemically synthesized InP/ZnS core/shell quantum dots (QDs) are studied using time-resolved photoluminescence spectroscopy and x-ray diffraction. Zinc stearate, which is added during the synthesis of the InP core, significantly improves the optical characteristics of the QDs. The luminescence quantum yield (QY) reaches 60%-70% and the emission is tunable from 485 to 586 nm by varying the Zn2+:In3+ molar ratio and growth temperature. The observed increased Stokes shift, luminescence decay time, and QY in the presence of Zn are rationalized by the formation of an In(Zn)P alloy structure that causes band-edge fluctuation to enhance the confinement of the excited carriers.

Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. III. Acute and chronic effects of CAPs on heart rate, heart-rate fluctuation, and body temperature.

PubMed

Hwang, Jing-Shiang; Nadziejko, Christine; Chen, Lung Chi

2005-04-01

Normal mice (C57) and mice prone to develop atherosclerosis (ApoE-/-) were implanted with electrocardiograph (EKG), core body temperature, and motion transmitters were exposed daily for 6 h to Tuxedo, NY, concentrated ambient particles (CAPs) for 5 day/wk during the spring and summer of 2003. The series of 5-min EKG monitoring and body-temperature measurements were obtained for each animal in the CAPs and filtered air sham exposure groups. Our hypothesis was that chronic exposure could cause cumulative health effects. We used our recently developed nonparametric method to estimate the daily time periods that mean heart rates (HR), body temperature, and physical activity differed significantly between the CAPs and sham exposed group. CAPs exposure most affected heart rate between 1:30 a.m. and 4:30 a.m. With the response variables being the average heart rate, body temperature, and physical activity, we adopted a two-stage modeling approach to obtain the estimates of chronic and acute effects on the changes of these three response variables. In the first stage, a time-varying model estimated daily crude effects. In the second stage, the true means of the estimated crude effects were modeled with a polynominal function of time for chronic effects, a linear term of daily CAPs exposure concentrations for acute effects, and a random component for unknown noise. A Bayesian framework combined these two stages. There were significant decreasing patterns of HR, body temperature, and physical activity for the ApoE-/- mice over the 5 mo of CAPs exposure, with smaller and nonsignificant changes for the C57 mice. The chronic effect changes of the three response variables for ApoE-/- mice were maximal in the last few weeks. There was also a significant relationship between CAPs exposure concentration and short-term changes of heart rate in ApoE-/- mice during exposure. Response variables were also defined for examining fluctuations of 5-min heart rates within long (i.e., 3-6 h) and short time periods (i.e., approximately 15 min). The results for the ApoE-/- mice showed that heart-rate fluctuation within the longer periods increased to 1.35-fold by the end of exposure experiment, while the heart-rate fluctuation within 15 min decreased to 0.7-fold.

The metabolic activator FOXO1 binds hepatitis B virus DNA and activates its transcription

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shlomai, Amir, E-mail: amirsh@tasmc.health.gov.il; Institute for Gastroenterology and Liver disease, Tel-Aviv Sourasky Medical Center, 6 Weizmann street, Tel-Aviv; Shaul, Yosef

2009-04-17

Hepatitis B virus (HBV) is a small DNA virus that targets the liver and infects humans worldwide. Recently we have shown that the metabolic regulator PGC-1{alpha} coactivates HBV transcription thereby rendering the virus susceptible to fluctuations in the nutritional status of the liver. PGC-1{alpha} coactivation of HBV is mediated through the liver-enriched nuclear receptor HNF4{alpha} and through another yet unknown transcription factor(s). Here we show that the forkhead transcription factor FOXO1, a known target for PGC-1{alpha} coactivation and a central mediator of glucose metabolism in the liver, binds HBV core promoter and activates its transcription. This activation is further enhancedmore » in the presence of PGC-1{alpha}, implying that FOXO1 is a target for PGC-1{alpha} coactivation of HBV transcription. Thus, our results identify another key metabolic regulator as an activator of HBV transcription, thereby supporting the principle that HBV gene expression is regulated in a similar way to key hepatic metabolic genes.« less

Density-Gradient-Driven trapped-electron-modes in improved-confinement RFP plasmas

NASA Astrophysics Data System (ADS)

Duff, James; Sarff, John; Ding, Weixing; Brower, David; Parke, Eli; Chapman, Brett; Terry, Paul; Pueschel, M. J.; Williams, Zach

2017-10-01

Short wavelength density fluctuations in improved-confinement MST plasmas exhibit multiple features characteristic of the trapped-electron-mode (TEM). Core transport in the RFP is normally governed by magnetic stochasticity stemming from long wavelength tearing modes that arise from current profile peaking, which are suppressed via inductive control for this work. The improved confinement is associated with an increase in the pressure gradient that can destabilize drift waves. The measured density fluctuations have f 50 kHz, kϕρs < 0.14 , and propagate in the electron drift direction. Their spectral emergence coincides with a sharp decrease in global tearing mode associated fluctuations, their amplitude increases with local density gradient, and they exhibit a density-gradient threshold at R /Ln 15 . The GENE code, modified for the RFP, predicts the onset of density-gradient-driven TEM for these strong-gradient plasma conditions. While nonlinear analysis shows a large Dimits shift associated with predicted strong zonal flows, the inclusion of residual magnetic fluctuations, comparable to experimental magnetic fluctuations, causes a collapse of the zonal flows and an increase in the predicted transport to a level close to the experimentally measured heat flux. Work supported by US DOE.

Propagation of radio frequency waves through density fluctuations

NASA Astrophysics Data System (ADS)

Valvis, S. I.; Papagiannis, P.; Papadopoulos, A.; Hizanidis, K.; Glytsis, E.; Bairaktaris, F.; Zisis, A.; Tigelis, I.; Ram, A. K.

2017-10-01

On their way to the core of a tokamak plasma, radio frequency (RF) waves, excited in the vacuum region, have to propagate through a variety of density fluctuations in the edge region. These fluctuations include coherent structures, like blobs that can be field aligned or not, as well as turbulent and filamentary structures. We have been studying the effect of fluctuations on RF propagation using both theoretical (analytical) and computational models. The theoretical results are being compared with those obtained by two different numerical codes ``a Finite Difference Frequency Domain code and the commercial COMSOL package. For plasmas with arbitrary distribution of coherent and turbulent fluctuations, we have formulated an effective dielectric permittivity of the edge plasma. This permittivity tensor is then used in numerical simulations to study the effect of multi-scale turbulence on RF waves. We not only consider plane waves but also Gaussian beams in the electron cyclotron and lower hybrid range of frequencies. The analytical theory and results from simulations on the propagation of RF waves will be presented. Supported in part by the Hellenic National Programme on Controlled Thermonuclear Fusion associated with the EUROfusion Consortium and by DoE Grant DE-FG02-91ER-54109.

Prospects for reconstructing paleoenvironmental conditions from organic compounds in polar snow and ice

USGS Publications Warehouse

Giorio, Chiara; Kehrwald, Natalie; Barbante, Carlo; Kalberer, Markus; King, Amy C.F.; Thomas, Elizabeth R.; Wolff, Eric W.; Zennaro, Piero

2018-01-01

Polar ice cores provide information about past climate and environmental changes over periods ranging from a few years up to 800,000 years. The majority of chemical studies have focused on determining inorganic components, such as major ions and trace elements as well as on their isotopic fingerprint. In this paper, we review the different classes of organic compounds that might yield environmental information, discussing existing research and what is needed to improve knowledge. We also discuss the problems of sampling, analysis and interpretation of organic molecules in ice. This review highlights the great potential for organic compounds to be used as proxies for anthropogenic activities, past fire events from different types of biomass, terrestrial biogenic emissions and marine biological activity, along with the possibility of inferring past temperature fluctuations and even large-scale climate variability. In parallel, comprehensive research needs to be done to assess the atmospheric stability of these compounds, their ability to be transported long distances in the atmosphere, and their stability in the archive in order to better interpret their fluxes in ice cores. In addition, specific decontamination procedures, analytical methods with low detection limits (ng/L or lower), fast analysis time and low sample requests need to be developed in order to ensure a good time resolution in the archive.

Prospects for reconstructing paleoenvironmental conditions from organic compounds in polar snow and ice

NASA Astrophysics Data System (ADS)

Giorio, Chiara; Kehrwald, Natalie; Barbante, Carlo; Kalberer, Markus; King, Amy C. F.; Thomas, Elizabeth R.; Wolff, Eric W.; Zennaro, Piero

2018-03-01

Polar ice cores provide information about past climate and environmental changes over periods ranging from a few years up to 800,000 years. The majority of chemical studies have focused on determining inorganic components, such as major ions and trace elements as well as on their isotopic fingerprint. In this paper, we review the different classes of organic compounds that might yield environmental information, discussing existing research and what is needed to improve knowledge. We also discuss the problems of sampling, analysis and interpretation of organic molecules in ice. This review highlights the great potential for organic compounds to be used as proxies for anthropogenic activities, past fire events from different types of biomass, terrestrial biogenic emissions and marine biological activity, along with the possibility of inferring past temperature fluctuations and even large-scale climate variability. In parallel, comprehensive research needs to be done to assess the atmospheric stability of these compounds, their ability to be transported long distances in the atmosphere, and their stability in the archive in order to better interpret their fluxes in ice cores. In addition, specific decontamination procedures, analytical methods with low detection limits (ng/L or lower), fast analysis time and low sample requests need to be developed in order to ensure a good time resolution in the archive.

Seismic Structure in the Vicinity of the Inner Core Boundary beneath northeastern Asia

NASA Astrophysics Data System (ADS)

Ibourichene, A. S.; Romanowicz, B. A.

2016-12-01

The inner core boundary (ICB) separates the solid inner core from the liquid outer core. The crystallization of iron occurring at this limit induces the expulsion of lighter elements such as H, O, S, Si into the outer core, generating chemically-driven convection, which provides power for the geodynamo. Both the F layer, right above the ICB, and the uppermost inner core, are affected by this process so that their properties provide important constraints for a better understanding of core dynamics and, ultimately, the generation and sustained character of the earth's magnetic field. In this study, we investigate the evolution of model parameters (P-velocity, density and quality factor) with depth in the vicinity of the ICB. For this purpose, we combine observations of two body wave phases sensitive to this region: the PKP(DF) phase refracted in the inner core and the PKiKP reflected on the ICB. Variations in the PKP(DF)/PKiKP amplitude ratio and PKP(DF)-PKiKP differential travel times can be related to structure around the ICB. We use waveform data from earthquakes located in Sumatra and recorded by the dense USArray seismic network, which allows us to sample ICB structure beneath northeastern Asia. Observed waveforms are compared to synthetics computed using the DSM method (e.g., Geller et Takeuchi, 1995) in model AK135 (e.g., Montagner & Kennett, 1996) in order to measure amplitude and travel time anomalies. Previous studies (e.g., Tanaka, 1997 ; Cao and Romanowicz, 2004, Yu and Wen, 2006; Waszek and Deuss, 2011) have observed an hemispherical pattern in the vicinity of the ICB exhibiting a faster and more attenuated eastern hemisphere compared to the western hemisphere. The region studied is located in the eastern hemisphere. We find that, on average, travel time anomalies are consistent with previous studies of the eastern hemisphere, however, amplitude ratios are not. We conduct a parameter search for the 1D model that best fits our data. We also consider fluctuations around this best fitting average model and quantify the statistical properties of the short wavelength fluctuations.

Pressure fluctuations beneath instability wavepackets and turbulent spots in a hypersonic boundary layer

DOE PAGES

Casper, Katya M.; Beresh, Steven J.; Schneider, Steven P.

2014-09-09

To investigate the pressure-fluctuation field beneath turbulent spots in a hypersonic boundary layer, a study was conducted on the nozzle wall of the Boeing/AFOSR Mach-6 Quiet Tunnel. Controlled disturbances were created by pulsed-glow perturbations based on the electrical breakdown of air. Under quiet-flow conditions, the nozzle-wall boundary layer remains laminar and grows very thick over the long nozzle length. This allows the development of large disturbances that can be well-resolved with high-frequency pressure transducers. A disturbance first grows into a second-mode instability wavepacket that is concentrated near its own centreline. Weaker disturbances are seen spreading from the centre. The wavesmore » grow and become nonlinear before breaking down to turbulence. The breakdown begins in the core of the packets where the wave amplitudes are largest. Second-mode waves are still evident in front of and behind the breakdown point and can be seen propagating in the spanwise direction. The turbulent core grows downstream, resulting in a spot with a classical arrowhead shape. Behind the spot, a low-pressure calmed region develops. However, the spot is not merely a localized patch of turbulence; instability waves remain an integral part. Limited measurements of naturally occurring disturbances show many similar characteristics. From the controlled disturbance measurements, the convection velocity, spanwise spreading angle, and typical pressure-fluctuation field were obtained.« less

Intrinsically-generated fluctuating activity in excitatory-inhibitory networks.

PubMed

Mastrogiuseppe, Francesca; Ostojic, Srdjan

2017-04-01

Recurrent networks of non-linear units display a variety of dynamical regimes depending on the structure of their synaptic connectivity. A particularly remarkable phenomenon is the appearance of strongly fluctuating, chaotic activity in networks of deterministic, but randomly connected rate units. How this type of intrinsically generated fluctuations appears in more realistic networks of spiking neurons has been a long standing question. To ease the comparison between rate and spiking networks, recent works investigated the dynamical regimes of randomly-connected rate networks with segregated excitatory and inhibitory populations, and firing rates constrained to be positive. These works derived general dynamical mean field (DMF) equations describing the fluctuating dynamics, but solved these equations only in the case of purely inhibitory networks. Using a simplified excitatory-inhibitory architecture in which DMF equations are more easily tractable, here we show that the presence of excitation qualitatively modifies the fluctuating activity compared to purely inhibitory networks. In presence of excitation, intrinsically generated fluctuations induce a strong increase in mean firing rates, a phenomenon that is much weaker in purely inhibitory networks. Excitation moreover induces two different fluctuating regimes: for moderate overall coupling, recurrent inhibition is sufficient to stabilize fluctuations; for strong coupling, firing rates are stabilized solely by the upper bound imposed on activity, even if inhibition is stronger than excitation. These results extend to more general network architectures, and to rate networks receiving noisy inputs mimicking spiking activity. Finally, we show that signatures of the second dynamical regime appear in networks of integrate-and-fire neurons.

Intrinsically-generated fluctuating activity in excitatory-inhibitory networks

PubMed Central

Mastrogiuseppe, Francesca; Ostojic, Srdjan

2017-01-01

Recurrent networks of non-linear units display a variety of dynamical regimes depending on the structure of their synaptic connectivity. A particularly remarkable phenomenon is the appearance of strongly fluctuating, chaotic activity in networks of deterministic, but randomly connected rate units. How this type of intrinsically generated fluctuations appears in more realistic networks of spiking neurons has been a long standing question. To ease the comparison between rate and spiking networks, recent works investigated the dynamical regimes of randomly-connected rate networks with segregated excitatory and inhibitory populations, and firing rates constrained to be positive. These works derived general dynamical mean field (DMF) equations describing the fluctuating dynamics, but solved these equations only in the case of purely inhibitory networks. Using a simplified excitatory-inhibitory architecture in which DMF equations are more easily tractable, here we show that the presence of excitation qualitatively modifies the fluctuating activity compared to purely inhibitory networks. In presence of excitation, intrinsically generated fluctuations induce a strong increase in mean firing rates, a phenomenon that is much weaker in purely inhibitory networks. Excitation moreover induces two different fluctuating regimes: for moderate overall coupling, recurrent inhibition is sufficient to stabilize fluctuations; for strong coupling, firing rates are stabilized solely by the upper bound imposed on activity, even if inhibition is stronger than excitation. These results extend to more general network architectures, and to rate networks receiving noisy inputs mimicking spiking activity. Finally, we show that signatures of the second dynamical regime appear in networks of integrate-and-fire neurons. PMID:28437436

Who’s on top? SST proxy comparison from the Peru Margin Upwelling System

NASA Astrophysics Data System (ADS)

Chazen, C.; Herbert, T.; Altabet, M. A.

2009-12-01

The Peru Margin upwelling region is situated at the interface between the poleward Peru Undercurrent and the equatorward Peru Coastal current. Strong coastal winds force cold, nutrient-rich thermocline waters to the surface. Sea surface temperatures in this region fluctuate sub-annually with changes in the position of the Intertropical convergence zone (ITCZ) and sub-decadally with modifications in the strength of Walker Circulation. In contrast, the temperature of the Peru Margin thermocline is stable, isolated from surface winds and slow to respond to major perturbations in surface temperature. Using high resolution sampling (6-7 year) across an annually laminated sediment core from the heart of the Peru Margin upwelling system (15°S) we explore how Uk’37 temperatures compare with TEX86 temperatures across a 200-year interval in the Mid-late Holocene. Mean late Holocene Uk’37 temperatures, extracted from a high sedimentation rate core from the Peru Margin are similar to modern mean annual sea surface temperatures at 15°S. Multi-decadal-scale (50-100 year) Uk’37 temperature fluctuations oscillate about the mean by 1.5°C. These rapid temperature changes are coherent with fluctuations in surface productivity (C37total and Biogenic Silica) in addition to sub-surface denitrification (δ15N). In contrast, TEX86 temperatures derived from identical samples exhibit colder temperatures than modern mean annual conditions and virtually no temperature fluctuation. We posit that TEX86 values are recording temperatures below the photic zone near the mix-layer-thermocline boundary and may, on longer timescales provide invaluable information about thermocline temperature. With this interpretation in mind, we present a TEX86-based long-term thermocline reconstruction over the Holocene.

Self-assembly of BODIPY based pH-sensitive near-infrared polymeric micelles for drug controlled delivery and fluorescence imaging applications.

PubMed

Liu, Xiaodong; Chen, Bizheng; Li, Xiaojun; Zhang, Lifen; Xu, Yujie; Liu, Zhuang; Cheng, Zhenping; Zhu, Xiulin

2015-10-21

Responsive block copolymer micelles emerging as promising imaging and drug delivery systems show high stability and on-demand drug release activities. Herein, we developed self-assembled pH-responsive NIR emission micelles entrapped with doxorubicin (DOX) within the cores by the electrostatic interactions for fluorescence imaging and chemotherapy applications. The block copolymer, poly(methacrylic acid)-block-poly[(poly(ethylene glycol) methyl ether methacrylate)-co-boron dipyrromethene derivatives] (PMAA-b-P(PEGMA-co-BODIPY), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and the molecular weight distribution of this copolymer was narrow (Mw/Mn = 1.31). The NIR fluorescence enhancement induced by the phenol/phenolate interconversion equilibrium works as a switch in response to the intracellular pH fluctuations. DOX-loaded PMAA-b-P(PEGMA-co-BODIPY) micelles can detect the physiological pH fluctuations with a pKa near physiological conditions (∼7.52), and showed pH-responsive collapse and an obvious acid promoted anticancer drug release behavior (over 58.8-62.8% in 10 h). Real-time imaging of intracellular pH variations was performed and a significant chemotherapy effect was demonstrated against HeLa cells.

A high etendue spectrometer suitable for core charge eXchange recombination spectroscopy on ITER.

PubMed

Jaspers, R J E; Scheffer, M; Kappatou, A; van der Valk, N C J; Durkut, M; Snijders, B; Marchuk, O; Biel, W; Pokol, G I; Erdei, G; Zoletnik, S; Dunai, D

2012-10-01

A feasibility study for the use of core charge exchange recombination spectroscopy on ITER has shown that accurate measurements on the helium ash require a spectrometer with a high etendue of 1mm(2)sr to comply with the measurement requirements [S. Tugarinov et al., Rev. Sci. Instrum. 74, 2075 (2003)]. To this purpose such an instrument has been developed consisting of three separate wavelength channels (to measure simultaneously He/Be, C/Ne, and H/D/T together with the Doppler shifted direct emission of the diagnostic neutral beam, the beam emission (BES) signal), combining high dispersion (0.02 nm/pixel), sufficient resolution (0.2 nm), high efficiency (55%), and extended wavelength range (14 nm) at high etendue. The combined measurement of the BES along the same sightline within a third wavelength range provides the possibility for in situ calibration of the charge eXchange recombination spectroscopy signals. In addition, the option is included to use the same instrument for measurements of the fast fluctuations of the beam emission intensity up to 2 MHz, with the aim to study MHD activity.

REVISED MODEL OF THE STEADY-STATE SOLAR WIND HALO ELECTRON VELOCITY DISTRIBUTION FUNCTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Peter H.; Kim, Sunjung; Choe, G. S.

2016-08-01

A recent study discussed the steady-state model for solar wind electrons during quiet time conditions. The electrons emanating from the Sun are treated in a composite three-population model—the low-energy Maxwellian core with an energy range of tens of eV, the intermediate ∼10{sup 2}–10{sup 3} eV energy-range (“halo”) electrons, and the high ∼10{sup 3}–10{sup 5} eV energy-range (“super-halo”) electrons. In the model, the intermediate energy halo electrons are assumed to be in resonance with transverse EM fluctuations in the whistler frequency range (∼10{sup 2} Hz), while the high-energy super-halo electrons are presumed to be in steady-state wave–particle resonance with higher-frequency electrostaticmore » fluctuations in the Langmuir frequency range (∼10{sup 5} Hz). A comparison with STEREO and WIND spacecraft data was also made. However, ignoring the influence of Langmuir fluctuations on the halo population turns out to be an unjustifiable assumption. The present paper rectifies the previous approach by including both Langmuir and whistler fluctuations in the construction of the steady-state velocity distribution function for the halo population, and demonstrates that the role of whistler-range fluctuation is minimal unless the fluctuation intensity is arbitrarily raised. This implies that the Langmuir-range fluctuations, known as the quasi thermal noise, are important for both halo and super-halo electron velocity distribution.« less

Radioecological assessment and radiometric dating of sediment cores from dynamic sedimentary systems of Pra and Volta estuaries (Ghana) along the Equatorial Atlantic.

PubMed

Klubi, E; Abril, J M; Nyarko, E; Laissaoui, A; Benmansour, M

2017-11-01

The Volta and Pra estuaries (Ghana, West Africa) are dynamical sedimentary systems whose natural equilibrium is being affected by anthropogenic activities. This paper reports depth-distributions of 210 Pb, 226 Ra, 234 Th, 40 K, 228 Ra and 137 Cs for two sediment cores from these estuaries. Bulk densities were not steady-state and well correlated with 40 K (p < 0.00005). Unsupported 210 Pb profiles were incomplete, non-monotonic and showed large fluctuations. The assumptions involved in the common 210 Pb-based dating models were not meet in these dynamical scenarios, and the use of 137 Cs as a time-marker is difficult in Equatorial and South-Hemisphere countries due to its low fallout rates. Chronologies have been solved with the new 210 Pb-based TERESA model, which operates with varying but statistically correlated fluxes and sediment accumulation rates (SAR). The core from the Volta reflects the conditions prevailing after the construction of the Akosombo Dam, with a mean SAR of 1.05 ± 0.03 g cm -2 ·y -1 , while a higher value of 2.73 ± 0.06 g cm -2 ·y -1 was found in the Pra, affected by intense gold mining activities along its course. Radiological and radioecological assessments have been conducted by applying the UNSCEAR protocols and the ERICA model, respectively. The measured radionuclide concentrations do not pose any significant risk for the environment and human health. Copyright © 2017 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muljadi, Eduard; Hasan, Iftekhar; Husain, Tausif

This research examines the vibration and thermal characteristics of double-sided flux concentrating Transverse Flux Machines (TFM), designed for direct drive application. Two TFM prototypes with different stator cores, one with Quasi U-Core and the other with E-Core, has been used for the study. 3D Finite Element Analysis (FEA) has been carried out to determine the no-load and with load performance of the TFMs along with their fluctuating axial electromagnetic force densities acting on the stator teeth. The deformation response of the stator cores was observed in the static structural analysis. Thermal analysis for the TFM was performed through FEA basedmore » on copper and iron losses in the machine to examine the temperature rise in different parts of the machine structure. Acceleration and noise measurements were experimentally obtained to characterize the vibrational performance of the prototypes.« less

Hybrid Analysis of Engine Core Noise

NASA Astrophysics Data System (ADS)

O'Brien, Jeffrey; Kim, Jeonglae; Ihme, Matthias

2015-11-01

Core noise, or the noise generated within an aircraft engine, is becoming an increasing concern for the aviation industry as other noise sources are progressively reduced. The prediction of core noise generation and propagation is especially challenging for computationalists since it involves extensive multiphysics including chemical reaction and moving blades in addition to the aerothermochemical effects of heated jets. In this work, a representative engine flow path is constructed using experimentally verified geometries to simulate the physics of core noise. A combustor, single-stage turbine, nozzle and jet are modeled in separate calculations using appropriate high fidelity techniques including LES, actuator disk theory and Ffowcs-Williams Hawkings surfaces. A one way coupling procedure is developed for passing fluctuations downstream through the flowpath. This method effectively isolates the core noise from other acoustic sources, enables straightforward study of the interaction between core noise and jet exhaust, and allows for simple distinction between direct and indirect noise. The impact of core noise on the farfield jet acoustics is studied extensively and the relative efficiency of different disturbance types and shapes is examined in detail.

Magnetic and velocity fluctuations from nonlinearly coupled tearing modes in the reversed field pinch with and without the reversal surface

NASA Astrophysics Data System (ADS)

Craig, D.; Martin, D.; Den Hartog, D. J.; Nornberg, M. D.; Reusch, J. A.

2017-08-01

We investigate the role of poloidal mode number m = 0 fluctuations on m = 1 velocity and magnetic field fluctuations in the Reversed Field Pinch (RFP). Removing the m = 0 resonant surface in the Madison Symmetric Torus (MST), results in suppressed m = 0 activity without a reduction in m = 1 magnetic activity. However, the m = 1 velocity fluctuations and fluctuation-induced mean emf are reduced as m = 0 modes are suppressed. Velocity fluctuations are measured directly using fast Doppler spectroscopy. Similar results are seen in visco-resistive MHD simulation with the DEBS code. An artificial line-averaged velocity diagnostic is developed for DEBS simulations to facilitate direct comparisons with experimental measurements. The sensitivity of the m = 1 velocity fluctuations and corresponding emf to changes in m = 0 mode activity is a feature of tearing modes in the nonlinear regime with a spectrum of interacting modes. These results have implications for RFP sustainment strategies and inform our understanding of the role of magnetic turbulence in astrophysical contexts.

Properties of the edge plasma in the rebuilt Extrap-T2R reversed field pinch experiment

NASA Astrophysics Data System (ADS)

Vianello, N.; Spolaore, M.; Serianni, G.; Bergsåker, H.; Antoni, V.; Drake, J. R.

2002-12-01

The edge region of the rebuilt Extrap-T2R reversed field pinch experiment has been investigated using Langmuir probes. Radial profiles of main plasma parameters are obtained and compared with those of the previous device Extrap-T2. The spontaneous setting up of a double shear layer of E×B toroidal velocity is confirmed. The particle flux induced by electrostatic fluctuations is calculated and the resulting effective diffusion coefficient is consistent with the Bohm estimate. A close relationship between electrostatic fluctuations at the edge and non-linear coupling of MHD modes in the core is found.

Measurement of turbulence decorrelation during transport barrier evolution in a high-temperature fusion plasma.

PubMed

Nazikian, R; Shinohara, K; Kramer, G J; Valeo, E; Hill, K; Hahm, T S; Rewoldt, G; Ide, S; Koide, Y; Oyama, Y; Shirai, H; Tang, W

2005-04-08

A low power polychromatic beam of microwaves is used to diagnose the behavior of turbulent fluctuations in the core of the JT-60U tokamak during the evolution of the internal transport barrier. A continuous reduction in the size of turbulent structures is observed concomitant with the reduction of the density scale length during the evolution of the internal transport barrier. The density correlation length decreases to the order of the ion gyroradius, in contrast with the much longer scale lengths observed earlier in the discharge, while the density fluctuation level remain similar to the level before transport barrier formation.

A phase contrast imaging-interferometer system for detection of multiscale electron density fluctuations on DIII-D

NASA Astrophysics Data System (ADS)

Davis, E. M.; Rost, J. C.; Porkolab, M.; Marinoni, A.; Van Zeeland, M. A.

2016-11-01

Heterodyne interferometry and phase contrast imaging (PCI) are robust, mature techniques for measuring low-k and high-k electron density fluctuations, respectively. This work describes the first-ever implementation of a combined PCI-interferometer. The combined system uses a single 10.6 μm probe beam, two interference schemes, and two detectors to measure electron density fluctuations at large spatiotemporal bandwidth (10 kHz

Fluctuating chemohydrodynamics and the stochastic motion of self-diffusiophoretic particles

NASA Astrophysics Data System (ADS)

Gaspard, Pierre; Kapral, Raymond

2018-04-01

The propulsion of active particles by self-diffusiophoresis is driven by asymmetric catalytic reactions on the particle surface that generate a mechanochemical coupling between the fluid velocity and the concentration fields of fuel and product in the surrounding solution. Because of thermal and molecular fluctuations in the solution, the motion of micrometric or submicrometric active particles is stochastic. Coupled Langevin equations describing the translation, rotation, and reaction of such active particles are deduced from fluctuating chemohydrodynamics and fluctuating boundary conditions at the interface between the fluid and the particle. These equations are consistent with microreversibility and the Onsager-Casimir reciprocal relations between affinities and currents and provide a thermodynamically consistent basis for the investigation of the dynamics of active particles propelled by diffusiophoretic mechanisms.

The role of plastic β-hairpin and weak hydrophobic core in the stability and unfolding of a full sequence design protein

NASA Astrophysics Data System (ADS)

Lei, Hongxing; Duan, Yong

2004-12-01

In this study, the thermal stability of a designed α/β protein FSD (full sequence design) was studied by explicit solvent simulations at three moderate temperatures, 273 K, 300 K, and 330 K. The average properties of the ten trajectories at each temperature were analyzed. The thermal unfolding, as judged by backbone root-mean-square deviation and percentage of native contacts, was displayed with increased sampling outside of the native basin as the temperature was raised. The positional fluctuation of the hairpin residues was significantly higher than that of the helix residues at all three temperatures. The hairpin segment displayed certain plasticity even at 273 K. Apart from the terminal residues, the highest fluctuation was shown in the turn residues 7-9. Secondary structure analysis manifested the structural heterogeneity of the hairpin segment. It was also revealed by the simulation that the hydrophobic core was vulnerable to thermal denaturation. Consistent with the experiment, the I7Y mutation in the double mutant FSD-EY (FSD with mutations Q1E and I7Y) dramatically increased the protein stability in the simulation, suggesting that the plasticity of the hairpin can be partially compensated by a stronger hydrophobic core. As for the unfolding pathway, the breathing of the hydrophobic core and the separation of the two secondary structure elements (α helix and β hairpin) was the initiation step of the unfolding. The loss of global contacts from the separation further destabilized the hairpin structure and also led to the unwinding of the helix.

The role of plastic beta-hairpin and weak hydrophobic core in the stability and unfolding of a full sequence design protein.

PubMed

Lei, Hongxing; Duan, Yong

2004-12-15

In this study, the thermal stability of a designed alpha/beta protein FSD (full sequence design) was studied by explicit solvent simulations at three moderate temperatures, 273 K, 300 K, and 330 K. The average properties of the ten trajectories at each temperature were analyzed. The thermal unfolding, as judged by backbone root-mean-square deviation and percentage of native contacts, was displayed with increased sampling outside of the native basin as the temperature was raised. The positional fluctuation of the hairpin residues was significantly higher than that of the helix residues at all three temperatures. The hairpin segment displayed certain plasticity even at 273 K. Apart from the terminal residues, the highest fluctuation was shown in the turn residues 7-9. Secondary structure analysis manifested the structural heterogeneity of the hairpin segment. It was also revealed by the simulation that the hydrophobic core was vulnerable to thermal denaturation. Consistent with the experiment, the I7Y mutation in the double mutant FSD-EY (FSD with mutations Q1E and I7Y) dramatically increased the protein stability in the simulation, suggesting that the plasticity of the hairpin can be partially compensated by a stronger hydrophobic core. As for the unfolding pathway, the breathing of the hydrophobic core and the separation of the two secondary structure elements (alpha helix and beta hairpin) was the initiation step of the unfolding. The loss of global contacts from the separation further destabilized the hairpin structure and also led to the unwinding of the helix. (c) 2004 American Institute of Physics

Nonlinear gyrokinetic simulations of the I-mode high confinement regime and comparisons with experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, A. E., E-mail: whitea@mit.edu; Howard, N. T.; Creely, A. J.

2015-05-15

For the first time, nonlinear gyrokinetic simulations of I-mode plasmas are performed and compared with experiment. I-mode is a high confinement regime, featuring energy confinement similar to H-mode, but without enhanced particle and impurity particle confinement [D. G. Whyte et al., Nucl. Fusion 50, 105005 (2010)]. As a consequence of the separation between heat and particle transport, I-mode exhibits several favorable characteristics compared to H-mode. The nonlinear gyrokinetic code GYRO [J. Candy and R. E. Waltz, J Comput. Phys. 186, 545 (2003)] is used to explore the effects of E × B shear and profile stiffness in I-mode and comparemore » with L-mode. The nonlinear GYRO simulations show that I-mode core ion temperature and electron temperature profiles are more stiff than L-mode core plasmas. Scans of the input E × B shear in GYRO simulations show that E × B shearing of turbulence is a stronger effect in the core of I-mode than L-mode. The nonlinear simulations match the observed reductions in long wavelength density fluctuation levels across the L-I transition but underestimate the reduction of long wavelength electron temperature fluctuation levels. The comparisons between experiment and gyrokinetic simulations for I-mode suggest that increased E × B shearing of turbulence combined with increased profile stiffness are responsible for the reductions in core turbulence observed in the experiment, and that I-mode resembles H-mode plasmas more than L-mode plasmas with regards to marginal stability and temperature profile stiffness.« less

Palaeohydrology of the Southwest Yukon Territory, Canada, based on multiproxy analyses of lake sediment cores from a depth transect

USGS Publications Warehouse

Anderson, L.; Abbott, M.B.; Finney, B.P.; Edwards, M.E.

2005-01-01

Lake-level variations at Marcella Lake, a small, hydrologically closed lake in the southwestern Yukon Territory, document changes in effective moisture since the early Holocene. Former water levels, driven by regional palaeohydrology, were reconstructed by multiproxy analyses of sediment cores from four sites spanning shallow to deep water. Marcella Lake today is thermally stratified, being protected from wind by its position in a depression. It is alkaline and undergoes bio-induced calcification. Relative accumulations of calcium carbonate and organic matter at the sediment-water interface depend on the location of the depositional site relative to the thermocline. We relate lake-level fluctuations to down-core stratigraphic variations in composition, geochemistry, sedimentary structures and to the occurrence of unconformities in four cores based on observations of modern limnology and sedimentation processes. Twenty-four AMS radiocarbon dates on macrofossils and pollen provide the lake-level chronology. Prior to 10 000 cal. BP water levels were low, but then they rose to 3 to 4 m below modern levels. Between 7500 and 5000 cal. BP water levels were 5 to 6 m below modern but rose by 4000 cal. BP. Between 4000 and 2000 cal. BP they were higher than modern. During the last 2000 years, water levels were either near or 1 to 2 m below modern levels. Marcella Lake water-level fluctuations correspond with previously documented palaeoenvironmental and palaeoclimatic changes and provide new, independent effective moisture information. The improved geochronology and quantitative water-level estimates are a framework for more detailed studies in the southwest Yukon. ?? 2005 Edward Arnold (Publishers) Ltd.

Broadband Electrophysiological Dynamics Contribute to Global Resting-State fMRI Signal.

PubMed

Wen, Haiguang; Liu, Zhongming

2016-06-01

Spontaneous activity observed with resting-state fMRI is used widely to uncover the brain's intrinsic functional networks in health and disease. Although many networks appear modular and specific, global and nonspecific fMRI fluctuations also exist and both pose a challenge and present an opportunity for characterizing and understanding brain networks. Here, we used a multimodal approach to investigate the neural correlates to the global fMRI signal in the resting state. Like fMRI, resting-state power fluctuations of broadband and arrhythmic, or scale-free, macaque electrocorticography and human magnetoencephalography activity were correlated globally. The power fluctuations of scale-free human electroencephalography (EEG) were coupled with the global component of simultaneously acquired resting-state fMRI, with the global hemodynamic change lagging the broadband spectral change of EEG by ∼5 s. The levels of global and nonspecific fluctuation and synchronization in scale-free population activity also varied across and depended on arousal states. Together, these results suggest that the neural origin of global resting-state fMRI activity is the broadband power fluctuation in scale-free population activity observable with macroscopic electrical or magnetic recordings. Moreover, the global fluctuation in neurophysiological and hemodynamic activity is likely modulated through diffuse neuromodulation pathways that govern arousal states and vigilance levels. This study provides new insights into the neural origin of resting-state fMRI. Results demonstrate that the broadband power fluctuation of scale-free electrophysiology is globally synchronized and directly coupled with the global component of spontaneous fMRI signals, in contrast to modularly synchronized fluctuations in oscillatory neural activity. These findings lead to a new hypothesis that scale-free and oscillatory neural processes account for global and modular patterns of functional connectivity observed with resting-state fMRI, respectively. Copyright © 2016 the authors 0270-6474/16/366030-11$15.00/0.

Ongoing activity in temporally coherent networks predicts intra-subject fluctuation of response time to sporadic executive control demands.

PubMed

Nozawa, Takayuki; Sugiura, Motoaki; Yokoyama, Ryoichi; Ihara, Mizuki; Kotozaki, Yuka; Miyauchi, Carlos Makoto; Kanno, Akitake; Kawashima, Ryuta

2014-01-01

Can ongoing fMRI BOLD signals predict fluctuations in swiftness of a person's response to sporadic cognitive demands? This is an important issue because it clarifies whether intrinsic brain dynamics, for which spatio-temporal patterns are expressed as temporally coherent networks (TCNs), have effects not only on sensory or motor processes, but also on cognitive processes. Predictivity has been affirmed, although to a limited extent. Expecting a predictive effect on executive performance for a wider range of TCNs constituting the cingulo-opercular, fronto-parietal, and default mode networks, we conducted an fMRI study using a version of the color-word Stroop task that was specifically designed to put a higher load on executive control, with the aim of making its fluctuations more detectable. We explored the relationships between the fluctuations in ongoing pre-trial activity in TCNs and the task response time (RT). The results revealed the existence of TCNs in which fluctuations in activity several seconds before the onset of the trial predicted RT fluctuations for the subsequent trial. These TCNs were distributed in the cingulo-opercular and fronto-parietal networks, as well as in perceptual and motor networks. Our results suggest that intrinsic brain dynamics in these networks constitute "cognitive readiness," which plays an active role especially in situations where information for anticipatory attention control is unavailable. Fluctuations in these networks lead to fluctuations in executive control performance.

Alfven resonance mode conversion in the Phaedrus-T current drive experiments: Modelling and density fluctuations measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vukovic, M.; Harper, M.; Breun, R.

1995-12-31

Current drive experiments on the Phaedrus-T tokamak performed with a low field side two-strap fast wave antenna at frequencies below {omega}{sub cH} show loop volt drops of up to 30% with strap phasing (0, {pi}/2). RF induced density fluctuations in the plasma core have also been observed with a microwave reflectometer. It is believed that they are caused by kinetic Alfven waves generated by mode conversion of fast waves at the Alfven resonance. Correlation of the observed density fluctuations with the magnitude of the {Delta}V{sub loop} suggest that the {Delta}V{sub loop} is attributable to current drive/heating due to mode convertedmore » kinetic Alfven waves. The toroidal cold plasma wave code LION is used to model the Alfven resonance mode conversion surfaces in the experiments while the cylindrical hot plasma kinetic wave code ISMENE is used to model the behavior of kinetic Alfven waves at the Alfven resonance location. Initial results obtained from limited density, magnetic field, antenna phase, and impurity scans show good agreement between the RF induced density fluctuations and the predicted behavior of the kinetic Alfven waves. Detailed comparisons between the density fluctuations and the code predictions are presented.« less

Orientation-dependent fiber-optic accelerometer based on grating inscription over fiber cladding.

PubMed

Rong, Qiangzhou; Qiao, Xueguang; Guo, Tuan; Bao, Weijia; Su, Dan; Yang, Hangzhou

2014-12-01

An orientation-sensitive fiber-optic accelerometer based on grating inscription over fiber cladding has been demonstrated. The sensor probe comprises a compact structure in which a short section of thin-core fiber (TCF) stub containing a "cladding" fiber Bragg grating (FBG) is spliced to another single-mode fiber (SMF) without any lateral offset. A femtosecond laser side-illumination technique was utilized to ensure that the grating inscription remains close to the core-cladding interface of the TCF. The core mode and the cladding mode of the TCF are coupled at the core-mismatch junction, and two well-defined resonances in reflection appear from the downstream FBG, in which the cladding resonance exhibits a strong polarization and bending dependence due to the asymmetrical distribution of the cladding FBG along the fiber cross section. Strong orientation dependence of the vibration (acceleration) measurement has been achieved by power detection of the cladding resonance. Meanwhile, the unwanted power fluctuations and temperature perturbations can be referenced out by monitoring the fundamental core resonance.

Quaternary coral reef refugia preserved fish diversity.

PubMed

Pellissier, Loïc; Leprieur, Fabien; Parravicini, Valeriano; Cowman, Peter F; Kulbicki, Michel; Litsios, Glenn; Olsen, Steffen M; Wisz, Mary S; Bellwood, David R; Mouillot, David

2014-05-30

The most prominent pattern in global marine biogeography is the biodiversity peak in the Indo-Australian Archipelago. Yet the processes that underpin this pattern are still actively debated. By reconstructing global marine paleoenvironments over the past 3 million years on the basis of sediment cores, we assessed the extent to which Quaternary climate fluctuations can explain global variation in current reef fish richness. Comparing global historical coral reef habitat availability with the present-day distribution of 6316 reef fish species, we find that distance from stable coral reef habitats during historical periods of habitat loss explains 62% of the variation in fish richness, outweighing present-day environmental factors. Our results highlight the importance of habitat persistence during periods of climate change for preserving marine biodiversity. Copyright © 2014, American Association for the Advancement of Science.

On Maximal Hard-Core Thinnings of Stationary Particle Processes

NASA Astrophysics Data System (ADS)

Hirsch, Christian; Last, Günter

2018-02-01

The present paper studies existence and distributional uniqueness of subclasses of stationary hard-core particle systems arising as thinnings of stationary particle processes. These subclasses are defined by natural maximality criteria. We investigate two specific criteria, one related to the intensity of the hard-core particle process, the other one being a local optimality criterion on the level of realizations. In fact, the criteria are equivalent under suitable moment conditions. We show that stationary hard-core thinnings satisfying such criteria exist and are frequently distributionally unique. More precisely, distributional uniqueness holds in subcritical and barely supercritical regimes of continuum percolation. Additionally, based on the analysis of a specific example, we argue that fluctuations in grain sizes can play an important role for establishing distributional uniqueness at high intensities. Finally, we provide a family of algorithmically constructible approximations whose volume fractions are arbitrarily close to the maximum.

[History of heavy metal pollution from tidal flat in Haizhou Bay].

PubMed

Zhang, Rui; Zhang, Fan; Liu, Fu-Cheng; Yin, Fu-Jun; Ding, Ying-Jun; Gao, Jin-Rong; Chen, Jing; Shao, Wei

2013-03-01

Coastal zone could be considered as an important sink of regional source to sink and preserve historical records of environmental evolution. Four sediment cores, collected from tidal flat at Haizhou Bay near Lianyungang City, were examined for concentrations of heavy metals including Cd, Cr, Cu, Mn, Pb and Zn in core sediments to investigate the historical input of trace metals. In addition, sediment rates of cores LH3 and LH4 were determined based on radionuclide 210Pb. The results showed that grain size control effect was not the main factor that influenced the distribution of heavy metals. Heavy metals concentrations in the surface sediments were higher than these regional background values. Furthermore, Al element as a proxy of grain size was selected for normalization and calculation of metal enrichment factor (EF) and anthropogenic heavy metal fluxes. The results revealed that heavy metals in tidal flats were continuously enriched in the past decades, meanwhile, tidal flats have been significantly subjected to contaminations due to anthropogenic activities. Moreover, the depth profiles of heavy metals fluxes correspond to scenario of social-economy development of Lianyungang, which is an important urban area near Haizhou Bay. From 1950s to 2005, anthropogenic fluxes of metals increased with fluctuations, whereas, since 2005 anthropogenic fluxes declined, which may be correlated to the adjustment of industrial structure as well as the strengthened environmental regulation.

Effect of Heating on Turbulent Density Fluctuations and Noise Generation From High Speed Jets

NASA Technical Reports Server (NTRS)

Panda, Jayanta; Seasholtz, Richard G.; Elam, Kristie A.; Mielke, Amy F.; Eck, Dennis G.

2004-01-01

Heated jets in a wide range of temperature ratios (TR), and acoustic Mach numbers (Ma) were investigated experimentally using far field microphones and a molecular Rayleigh scattering technique. The latter provided density fluctuations measurements. Two sets of operating conditions were considered: (1) TR was varied between 0.84 and 2.7 while Ma was fixed at 0.9; (2) Ma was varied between 0.6 and 1.48, while TR was fixed at 2.27. The implementation of the molecular Rayleigh scattering technique required dust removal and usage of a hydrogen combustor to avoid soot particles. Time averaged density measurements in the first set of data showed differences in the peripheral density shear layers between the unheated and heated jets. The nozzle exit shear layer showed increased turbulence level with increased plume temperature. Nevertheless, further downstream the density fluctuations spectra are found to be nearly identical for all Mach number and temperature ratio conditions. To determine noise sources a correlation study between plume density fluctuations and far field sound pressure fluctuations was conducted. For all jets the core region beyond the end of the potential flow was found to be the strongest noise source. Except for an isothermal jet, the correlations did not differ significantly with increasing temperature ratio. The isothermal jet created little density fluctuations. Although the far field noise from this jet did not show any exceptional trend, the flow-sound correlations were very low. This indicated that the density fluctuations only acted as a "tracer parameter" for the noise sources.

Modulation of Core Turbulent Density Fluctuations by Large-Scale Neoclassical Tearing Mode Islands in the DIII-D Tokamak

DOE PAGES

Bardóczi, L.; Rhodes, T. L.; Carter, T. A.; ...

2016-05-26

We report the first observation of localized modulation of turbulent density uctuations en (via Beam Emission Spectroscopy) by neoclassical tearing modes (NTMs) in the core of the DIII-D tokamak. NTMs are important as they often lead to severe degradation of plasma confinement and disruptions in high-confinement fusion experiments. Magnetic islands associated with NTMs significantly modify the profiles and turbulence drives. In this experiment n was found to be modulated by 14% across the island. Gyrokinetic simulations suggest that en could be dominantly driven by the ion temperature gradient (ITG) instability.

Fluctuation spectra and force generation in nonequilibrium systems.

PubMed

Lee, Alpha A; Vella, Dominic; Wettlaufer, John S

2017-08-29

Many biological systems are appropriately viewed as passive inclusions immersed in an active bath: from proteins on active membranes to microscopic swimmers confined by boundaries. The nonequilibrium forces exerted by the active bath on the inclusions or boundaries often regulate function, and such forces may also be exploited in artificial active materials. Nonetheless, the general phenomenology of these active forces remains elusive. We show that the fluctuation spectrum of the active medium, the partitioning of energy as a function of wavenumber, controls the phenomenology of force generation. We find that, for a narrow, unimodal spectrum, the force exerted by a nonequilibrium system on two embedded walls depends on the width and the position of the peak in the fluctuation spectrum, and oscillates between repulsion and attraction as a function of wall separation. We examine two apparently disparate examples: the Maritime Casimir effect and recent simulations of active Brownian particles. A key implication of our work is that important nonequilibrium interactions are encoded within the fluctuation spectrum. In this sense, the noise becomes the signal.

Anisotropy of magnetic susceptibility as a tool for recognizing core deformation: reevaluation of the paleomagnetic record of Pleistocene sediments from drill hole OL-92, Owens Lake, California

USGS Publications Warehouse

Rosenbaum, Joseph; Reynolds, Richard T.; Smoot, Joseph; Meyer, Robert

2000-01-01

At Owens Lake, California, paleomagnetic data document the Matuyama/Brunhes polarity boundary near the bottom of a 323-m core (OL-92) and display numerous directional fluctuations throughout the Brunhes chron. Many of the intervals of high directional dispersion were previously interpreted to record magnetic excursions. For the upper ~120 m, these interpretations were tested using the anisotropy of magnetic susceptibility (AMS), which typically defines a subhorizontal planar fabric for sediments deposited in quiet water. AMS data from intervals of deformed core, determined from detailed analysis of sedimentary structures, were compared to a reference AMS fabric derived from undisturbed sediment. This comparison shows that changes in the AMS fabric provide a means of screening core samples for deformation and the associated paleomagnetic record for the adverse effects of distortion. For that portion of core OL-92 studied here (about the upper 120 m), the combined analyses of sedimentary structures and AMS data demonstrate that most of the paleomagnetic features, previously interpreted as geomagnetic excursions, are likely the result of core deformation.

Ionospheric irregularities and acoustic/gravity wave activity above low-latitude thunderstorms

DOE PAGES

Lay, Erin H.

2017-12-18

Ionospheric irregularities due to plasma bubbles, scintillation, and acoustic/gravity waves are studied in the low-latitude ionosphere in relation to thunderstorm activity. Ionospheric total electron content (TEC) measurements from the Low Latitude Ionospheric Sensor Network (LISN) and lightning measurements from the World-Wide Lightning Location Network (WWLLN) are compared during two summer months and two winter months in 2013. Large amplitude fluctuations in TEC are found to have a strongly-peaked diurnal pattern in the late evening and nighttime summer ionosphere. The maximum magnitude and coverage area of these fluctuations increases as thunderstorm area increases. Summertime mid-amplitude fluctuations do not exhibit the samemore » diurnal variation, but do increase in magnitude and coverage area as thunderstorm area increases. Wintertime ionospheric fluctuations do not appear to be related to thunderstorm activity. Lastly, these findings show that thunderstorms have an observable effect on magnitude and coverage area of ionospheric fluctuations.« less

Ionospheric irregularities and acoustic/gravity wave activity above low-latitude thunderstorms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lay, Erin H.

Ionospheric irregularities due to plasma bubbles, scintillation, and acoustic/gravity waves are studied in the low-latitude ionosphere in relation to thunderstorm activity. Ionospheric total electron content (TEC) measurements from the Low Latitude Ionospheric Sensor Network (LISN) and lightning measurements from the World-Wide Lightning Location Network (WWLLN) are compared during two summer months and two winter months in 2013. Large amplitude fluctuations in TEC are found to have a strongly-peaked diurnal pattern in the late evening and nighttime summer ionosphere. The maximum magnitude and coverage area of these fluctuations increases as thunderstorm area increases. Summertime mid-amplitude fluctuations do not exhibit the samemore » diurnal variation, but do increase in magnitude and coverage area as thunderstorm area increases. Wintertime ionospheric fluctuations do not appear to be related to thunderstorm activity. Lastly, these findings show that thunderstorms have an observable effect on magnitude and coverage area of ionospheric fluctuations.« less

Ionospheric Irregularities and Acoustic/Gravity Wave Activity Above Low-Latitude Thunderstorms

NASA Astrophysics Data System (ADS)

Lay, Erin H.

2018-01-01

Ionospheric irregularities due to plasma bubbles, scintillation, and acoustic/gravity waves are studied in the low-latitude ionosphere in relation to thunderstorm activity. Ionospheric total electron content (TEC) measurements from the Low Latitude Ionospheric Sensor Network and lightning measurements from the World-Wide Lightning Location Network are compared during two summer months and two winter months in 2013. Large amplitude fluctuations in TEC are found to have a strongly peaked diurnal pattern in the late evening and nighttime summer ionosphere. The maximum magnitude and coverage area of these fluctuations increases as thunderstorm area increases. Summertime midamplitude fluctuations do not exhibit the same diurnal variation but do increase in magnitude and coverage area as thunderstorm area increases. Wintertime ionospheric fluctuations do not appear to be related to thunderstorm activity. These findings show that thunderstorms have an observable effect on magnitude and coverage area of ionospheric fluctuations.

Anthropogenically induced environmental changes in the northeastern Adriatic Sea in the last 500 years (Panzano Bay, Gulf of Trieste)

NASA Astrophysics Data System (ADS)

Vidović, Jelena; Nawrot, Rafał; Gallmetzer, Ivo; Haselmair, Alexandra; Tomašových, Adam; Stachowitsch, Michael; Ćosović, Vlasta; Zuschin, Martin

2016-11-01

Shallow and sheltered marine embayments in urbanized areas are prone to the accumulation of pollutants, but little is known about the historical baselines of such marine ecosystems. Here we study foraminiferal assemblages, geochemical proxies and sedimentological data from 1.6 m long sediment cores to uncover ˜ 500 years of anthropogenic pressure from mining, port and industrial activities in the Gulf of Trieste, Italy. From 1600 to 1900 AD, normalized element concentrations and foraminiferal assemblages point to negligible effects of agricultural activities. The only significant anthropogenic activity during this period was mercury mining in the hinterlands of the gulf, releasing high amounts of mercury into the bay and significantly exceeding the standards on the effects of trace elements on benthic organisms. Nonetheless, the fluctuations in the concentrations of mercury do not correlate with changes in the composition and diversity of foraminiferal assemblages due to its non-bioavailability. Intensified agricultural and maricultural activities in the first half of the 20th century caused slight nutrient enrichment and a minor increase in foraminiferal diversity. Intensified port and industrial activities in the second half of 20th century increased the normalized trace element concentrations and persistent organic pollutants (PAH, PCB) in the topmost part of the core. This increase caused only minor changes in the foraminiferal community because foraminifera in Panzano Bay have a long history of adaptation to elevated trace element concentrations. Our study underlines the importance of using an integrated, multidisciplinary approach in reconstructing the history of environmental and anthropogenic changes in marine systems. Given the prolonged human impacts in coastal areas like the Gulf of Trieste, such long-term baseline data are crucial for interpreting the present state of marine ecosystems.

Core barrier formation near integer q surfaces in DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Austin, M. E.; Gentle, K. W.; Burrell, K. H.

2006-08-15

Recent DIII-D experiments have significantly improved the understanding of internal transport barriers (ITBs) that are triggered close to the time when an integer value of the minimum in q is crossed. While this phenomenon has been observed on many tokamaks, the extensive transport and fluctuation diagnostics on DIII-D have permitted a detailed study of the generation mechanisms of q-triggered ITBs as pertaining to turbulence suppression dynamics, shear flows, and energetic particle modes. In these discharges, the evolution of the q profile is measured using motional Stark effect polarimetry and the integer q{sub min} crossings are further pinpointed in time bymore » the observation of Alfven cascades. High time resolution measurements of the ion and electron temperatures and the toroidal rotation show that the start of improved confinement is simultaneous in all three channels, and that this event precedes the traversal of integer q{sub min} by 5-20 ms. There is no significant low-frequency magnetohydrodynamic activity prior to or just after the crossing of the integer q{sub min} and hence magnetic reconnection is determined not to be the precipitant of the confinement change. Instead, results from the GYRO code point to the effects of zonal flows near low order rational q values as playing a role in ITB triggering. A reduction in local turbulent fluctuations is observed at the start of the temperature rise and, concurrently, an increase in turbulence poloidal flow velocity and flow shear is measured with the beam emission spectroscopy diagnostic. For the case of a transition to an enduring internal barrier the fluctuation level remains at a reduced amplitude. The timing and nature of the temperature, rotation, and fluctuation changes leading to internal barriers suggests transport improvement due to increased shear flow arising from the zonal flow structures.« less

Fundamental and applied research on core engine/combustion noise of aircraft engines

NASA Technical Reports Server (NTRS)

Plett, E. G.; Leshner, M. D.; Summerfield, M.

1974-01-01

Some results of a study of the importance of geometrical features of the combustor to combustion roughness and resulting noise are presented. Comparison is made among a perforated can flame holder, a plane slotted flame holder and a plane slotted flame holder which introduces two counter swirling streams. The latter is found to permit the most stable, quiet combustion. Crosscorrelations between the time derivative of chamber pressure fluctuations and far field noise are found to be stronger than between the far field noise and the direct chamber pressure signal. Temperature fluctuations in the combustor nozzle are also found to have a reasonably strong crosscorrelation with far field sound.

Climatic Changes on Tibetan Plateau Based on Ice Core Records

NASA Astrophysics Data System (ADS)

Yao, T.

2008-12-01

Climatic changes have been reconstructed for the Tibetan Plateau based on ice core records. The Guliya ice core on the Tibetan Plateau presents climatic changes in the past 100,000 years, thus is comparative with that from Vostok ice core in Antarctica and GISP2 record in Arctic. These three records share an important common feature, i.e., our climate is not stable. It is also evident that the major patterns of climatic changes are similar on the earth. Why does climatic change over the earth follow a same pattern? It might be attributed to solar radiation. We found that the cold periods correspond to low insolation periods, and warm periods to high insolation periods. We found abrupt climatic change in the ice core climatic records, which presented dramatic temperature variation of as much as 10 °C in 50 or 60 years. Our major challenge in the study of both climate and environment is that greenhouse gases such as CO2, CH4 are possibly amplifying global warming, though at what degree remains unclear. One of the ways to understand the role of greenhouse gases is to reconstruct the past greenhouse gases recorded in ice. In 1997, we drilled an ice core from 7100 m a.s.l. in the Himalayas to reconstruct methane record. Based on the record, we found seasonal cycles in methane variation. In particular, the methane concentration is high in summer, suggestiing active methane emission from wet land in summer. Based on the seasonal cycle, we can reconstruct the methane fluctuation history in the past 500 years. The most prominent feature of the methane record in the Himalayan ice core is the abrupt increase since 1850 A.D.. This is closely related to the industrial revolution worldwide. We can also observe sudden decrease in methane concentration during the World War I and World War II. It implies that the industrial revolution has dominated the atmospheric greenhouse gas emission for about 100 years. Besides, the average methane concentration in the Himalayan ice core is higher than that in polar regions, indicating that the low latitude wet land is a major natural source of atmospheric methane.

Loess as an environmental archive of atmospheric trace element deposition

NASA Astrophysics Data System (ADS)

Blazina, T.; Winkel, L. H.

2013-12-01

Environmental archives such as ice cores, lake sediment cores, and peat cores have been used extensively to reconstruct past atmospheric deposition of trace elements. These records have provided information about how anthropogenic activities such as mining and fossil fuel combustion have disturbed the natural cycles of various atmospherically transported trace elements (e.g. Pb, Hg and Se). While these records are invaluable for tracing human impacts on such trace elements, they often provide limited information about the long term natural cycles of these elements. An assumption of these records is that the observed variations in trace element input, prior to any assumed anthropogenic perturbations, represent the full range of natural variations. However, records such as those mentioned above which extend back to a maximum of ~400kyr may not capture the potentially large variations of trace element input occurring over millions of years. Windblown loess sediments, often representing atmospheric deposition over time scales >1Ma, are the most widely distributed terrestrial sediments on Earth. These deposits have been used extensively to reconstruct continental climate variability throughout the Quaternary and late Neogene periods. In addition to being a valuable record of continental climate change, loess deposits may represent a long term environmental archive of atmospheric trace element deposition and may be combined with paleoclimate records to elucidate how fluctuations in climate have impacted the natural cycle of such elements. Our research uses the loess-paleosol deposits on the Chinese Loess Plateau (CLP) to quantify how atmospheric deposition of trace elements has fluctuated in central China over the past 6.8Ma. The CLP has been used extensively to reconstruct past changes of East Asian monsoon system (EAM). We present a suite of trace element concentration records (e.g. Pb, Hg, and Se) from the CLP which exemplifies how loess deposits can be used as an environmental archive to reconstruct long term natural variations in atmospheric trace element input. By comparing paleomonsoon proxy data with geochemical data we can directly correlate variations in atmospheric trace element input to fluctuations in the EAM. For example we are able to link Se input into the CLP to EAM derived precipitation. In interglacial climatic periods from 2.3-1.56Ma and 1.50-1.29Ma, we find very strong positive correlations between Se concentration and the summer monsoon index, a proxy for effective precipitation. In later interglacial periods from 1.26-0.83Ma and 0.78-0.16Ma, we find dust input plays a greater role. Our findings demonstrate that the CLP is a valuable environmental archive of atmospheric trace element deposition and suggest that other loess deposits worldwide may serve as useful records for investigating long term natural variations in atmospheric trace element cycling.

Vegetation history and palaeoclimate of the last glacial period at Lago Grande di Monticchio, Southern Italy

NASA Astrophysics Data System (ADS)

Watts, W. A.; Allen, J. R. M.; Huntley, B.

A high-resolution palynological study of a 51 m core from Lago Grande di Monticchio, southern Italy, has provided a palaeonvironmental record for the last glacill. A annual lamination based chronology, supported by radiometric and tephrochronological dates, provides an absolute timescale for this record that spans 76,300 years. Correlations are established between the pollen stratigraphy, the GRIP ice core δ18O record and foraminiferal assemblages from Atlantic core V23-81. Both Dansgaard-Oeschger and Heinrich events are reflected by changes in the pollen stratigraphy. Revised dates are estimated for Heinrich events H1-H6. A quantitative palaeoclimate reconstruction based upon the pollen data provides evidence of the climate changes in southern Italy associated with these and other fluctuations during the last glacial.

Surface flux density distribution characteristics of bulk high- Tc superconductor in external magnetic field

NASA Astrophysics Data System (ADS)

Torii, S.; Yuasa, K.

2004-10-01

Various magnetic levitation systems using oxide superconductors are developed as strong pinning forces are obtained in melt-processed bulk. However, the trapped flux of superconductor is moved by flux creep and fluctuating magnetic field. Therefore, to examine the internal condition of superconductor, the authors measure the dynamic surface flux density distribution of YBCO bulk. Flux density measurement system has a structure with the air-core coil and the Hall sensors. Ten Hall sensors are arranged in series. The YBCO bulk, which has 25 mm diameter and 13 mm thickness, is field cooled by liquid nitrogen. After that, magnetic field is changed by the air-core coil. This paper describes about the measured results of flux density distribution of YBCO bulk in the various frequencies of air-core coils currents.

Mitochondrial fluctuations as a measure of active biomechanical properties of mammalian cells

NASA Astrophysics Data System (ADS)

Xu, Wenlong; Alizadeh, Elaheh; Castle, Jordan; Prasad, Ashok

A single-cell assay of mechanical properties would give significant insights into cellular processes. Force spectrum microscopy is one such technique, which involves both active and passive particle tracking microrheology on the same cells. Since active microrheology requires expensive instruments, it is of great interest to develop simpler alternatives. Here we study an alternative using endogenous mitochondrial fluctuations, rather than fluorescent beads, in particle tracking microrheology. Mitochondria of the C3H-10T1/2 cell line are labeled and tracked using confocal microscopy, their mean square displacement (MSD) measured, and mechanical parameters calculated. Active fluctuations are distinguished from passive fluctuations by treatment with ATP synthesis inhibitors. We find that the MSD of mitochondria resembles that of particles in viscoelastic media. However, comparisons of MSD between controls and cells disrupted in the actin or microtubule network showed surprisingly small effects, while ATP-depleted cells showed significantly decreased MSD, and characteristics of thermally driven fluctuations. Both active and ATP-depleted parameters showed heterogeneity among cells and between cell lines. This method is potentially very useful due to its simplicity. We gratefully acknowledge support from NSF CAREER Grant PHY-1151454 awarded to Ashok Prasad.

Low-frequency oscillations in default mode subnetworks are associated with episodic memory impairments in Alzheimer's disease.

PubMed

Veldsman, Michele; Egorova, Natalia; Singh, Baljeet; Mungas, Dan; DeCarli, Charles; Brodtmann, Amy

2017-11-01

Disruptions to functional connectivity in subsystems of the default mode network are evident in Alzheimer's disease (AD). Functional connectivity estimates correlations in the time course of low-frequency activity. Much less is known about other potential perturbations to this activity, such as changes in the amplitude of oscillations and how this relates to cognition. We examined the amplitude of low-frequency fluctuations in 44 AD patients and 128 cognitively normal participants and related this to episodic memory, the core deficit in AD. We show higher amplitudes of low-frequency oscillations in AD patients. Rather than being compensatory, this appears to be maladaptive, with greater amplitude in the ventral default mode subnetwork associated with poorer episodic memory. Perturbations to default mode subnetworks in AD are evident in the amplitude of low-frequency oscillations in the resting brain. These disruptions are associated with episodic memory demonstrating their behavioral and clinical relevance in AD. Copyright © 2017 Elsevier Inc. All rights reserved.

Salinity fluctuation influencing biological adaptation: growth dynamics and Na+ /K+ -ATPase activity in a euryhaline bacterium.

PubMed

Yang, Hao; Meng, Yang; Song, Youxin; Tan, Yalin; Warren, Alan; Li, Jiqiu; Lin, Xiaofeng

2017-07-01

Although salinity fluctuation is a prominent characteristic of many coastal ecosystems, its effects on biological adaptation have not yet been fully recognized. To test the salinity fluctuations on biological adaptation, population growth dynamics and Na + /K + -ATPase activity were investigated in the euryhaline bacterium Idiomarina sp. DYB, which was acclimated at different salinity exposure levels, exposure times, and shifts in direction of salinity. Results showed: (1) bacterial population growth dynamics and Na + /K + -ATPase activity changed significantly in response to salinity fluctuation; (2) patterns of variation in bacterial growth dynamics were related to exposure times, levels of salinity, and shifts in direction of salinity change; (3) significant tradeoffs were detected between growth rate (r) and carrying capacity (K) on the one hand, and Na + /K + -ATPase activity on the other; and (4) beneficial acclimation was confirmed in Idiomarina sp. DYB. In brief, this study demonstrated that salinity fluctuation can change the population growth dynamics, Na + /K + -ATPase activity, and tradeoffs between r, K, and Na + /K + -ATPase activity, thus facilitating bacterial adaption in a changing environment. These findings provide constructive information for determining biological response patterns to environmental change. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mid-late Holocene variability of TEX86 temperature on the inner shelf of the East China Sea

NASA Astrophysics Data System (ADS)

Wu, X.; Xing, L.; Zhang, T.; Li, L.

2017-12-01

To understand the long-term environmental evolution of the East China Sea (ECS) and adjacent areas, decadal sea surface temperature (SST) induced by TEX86 (tetraether index of tetraethers consisting of 86 carbons) index was reconstructed in Core T08 on the inner shelf of the ECS over the past 3725 years. Core-top TEXH86 temperature was 23.2 °, close to the mean annual SST 22.9 ° at Site T08. BIT (branched and isopreniod tetraether) index and GDGT-0/GDGT-5 ratio indicated that the influences of terrestrial input and methanogens were negligible on TEX86 index, respectively. During the period of 3725-2000 yr BP, TEXH86 temperature had low values, fluctuating around 20 °, which suggested the weakened Kuroshio Current (KC) or the eastward shifting of the KC axis. From 2000 to 750 yr BP, TEXH86 temperature gradually increased to 23 °, indicating enhanced KC influence on Site T08. Significant reduction of TEXH86 temperature around 400 yr BP corresponded to Little Ice Age (LIA). Spectral analysis reveals that TEXH86 temperature series exhibit 175, 80, and 68-year periodicities, consistent with the characteristic periodicities of solar activity.

Retention of atmospheric Cu, Ni, Cd and Zn in an ombrotrophic peat profile near the Outokumpu Cu-Ni mine, SE-Finland

NASA Astrophysics Data System (ADS)

Rausch, N.; Nieminen, T. M.; Ukonmaanaho, L.; Cheburkin, A.; Krachler, M.; Shotyk, W.

2003-05-01

Peat cores taken from ombrotrophic bogs are widely used to reconstruct historical records of atmospheric lead and mercury déposition[1, 2]. In this study, the retention of copper, nickel, cadmium and zinc in peat bogs are studied by comparing high resolution, age dated concentration profiles with emissions from the main local source, the Outokumpu copper-nickel mine. An ombrotrophic peat core was taken from the vicinity of Outokumpu, E Finland. Copper and zinc concentrations of dry peat were measured by XRF, cadmium and nickel by GF-AAS, and sample ages by 210Pb. Only copper and nickel show enhanced concentrations in layers covering the mining period, indicating a retention of these elements. However, the more detailed comparison of ore production rates and concentrations in age-dated samples show clearly that only copper is likely to be permanently fixed, while nickel doesn't reflect the mining activity. Even though copper is retained in the upper part of the profile, a possible redeposition of this element by secondary processes (e.g., water table fluctuations) can not be excluded. This question will be resolved by further investigations, e.g. by pore water profiles.

Design of an Active Ultrastable Single-chain Insulin Analog

PubMed Central

Hua, Qing-xin; Nakagawa, Satoe H.; Jia, Wenhua; Huang, Kun; Phillips, Nelson B.; Hu, Shi-quan; Weiss, Michael A.

2008-01-01

Single-chain insulin (SCI) analogs provide insight into the inter-relation of hormone structure, function, and dynamics. Although compatible with wild-type structure, short connecting segments (<3 residues) prevent induced fit upon receptor binding and so are essentially without biological activity. Substantial but incomplete activity can be regained with increasing linker length. Here, we describe the design, structure, and function of a single-chain insulin analog (SCI-57) containing a 6-residue linker (GGGPRR). Native receptor-binding affinity (130 ± 8% relative to the wild type) is achieved as hindrance by the linker is offset by favorable substitutions in the insulin moiety. The thermodynamic stability of SCI-57 is markedly increased (ΔΔGu = 0.7 ± 0.1 kcal/mol relative to the corresponding two-chain analog and 1.9 ± 0.1 kcal/mol relative to wild-type insulin). Analysis of inter-residue nuclear Overhauser effects demonstrates that a native-like fold is maintained in solution. Surprisingly, the glycine-rich connecting segment folds against the insulin moiety: its central Pro contacts ValA3 at the edge of the hydrophobic core, whereas the final Arg extends the A1-A8 α-helix. Comparison between SCI-57 and its parent two-chain analog reveals striking enhancement of multiple native-like nuclear Overhauser effects within the tethered protein. These contacts are consistent with wild-type crystal structures but are ordinarily attenuated in NMR spectra of two-chain analogs, presumably due to conformational fluctuations. Linker-specific damping of fluctuations provides evidence for the intrinsic flexibility of an insulin monomer. In addition to their biophysical interest, ultrastable SCIs may enhance the safety and efficacy of insulin replacement therapy in the developing world. PMID:18332129

Identifying the adaptive mechanism in globular proteins: Fluctuations in densely packed regions manipulate flexible parts

NASA Astrophysics Data System (ADS)

Yilmaz, Lutfu Safak; Atilgan, Ali Rana

2000-09-01

A low-resolution structural model based on the packing geometry of α-carbons is utilized to establish a connection between the flexible and rigid parts of a folded protein. The former commonly recognizes a complementing molecule for making a complex, while the latter manipulates the necessary conformational change for binding. We attempt analytically to distinguish this control architecture that intrinsically exists in globular proteins. First with two-dimensional simple models, then for a native protein, bovine pancreatic trypsin inhibitor, we explicitly demonstrate that inserting fluctuations in tertiary contacts supported by the stable core, one can regulate the displacement of residues on loop regions. The positional fluctuations of the flexible regions are annihilated by the rest of the protein in conformity with the Le Chatelier-Braun principle. The results indicate that the distortion of the principal nonbonded contacts between highly packed residues is accompanied by that of the slavery fluctuations that are widely distributed over the native structure. These positional arrangements do not appear in a reciprocal relation between a perturbation and the associated response; the effect of a movement of residue i on residue j is not equal to that of the same movement of residue j on residue i.

NIR Ratiometric Luminescence Detection of pH Fluctuation in Living Cells with Hemicyanine Derivative-Assembled Upconversion Nanophosphors.

PubMed

Li, Haixia; Dong, Hao; Yu, Mingming; Liu, Chunxia; Li, Zhanxian; Wei, Liuhe; Sun, Ling-Dong; Zhang, Hongyan

2017-09-05

It is crucial for cell physiology to keep the homeostasis of pH, and it is highly demanded yet challenging to develop luminescence resonance energy transfer (LRET)-based near-infrared (NIR) ratiometric luminescent sensor for the detection of pH fluctuation with NIR excitation. As promising energy donors for LRET, upconversion nanoparticles (UCNPs) have been widely used to fabricate nanosensors, but the relatively low LRET efficiency limits their application in bioassay. To improve the LRET efficiency, core/shell/shell structured β-NaGdF 4 @NaYF 4 :Yb,Tm@NaYF 4 UCNPs were prepared and decorated with hemicyanine dyes as an LRET-based NIR ratiometric luminescent pH fluctuation-nanosensor for the first time. The as-developed nanosensor not only exhibits good antidisturbance ability, but it also can reversibly sense pH and linearly sense pH in a range of 6.0-9.0 and 6.8-9.0 from absorption and upconversion emission spectra, respectively. In addition, the nanosensor displays low dark toxicity under physiological temperature, indicating good biocompatibility. Furthermore, live cell imaging results revealed that the sensor can selectively monitor pH fluctuation via ratiometric upconversion luminescence behavior.

Extended MHD modeling of tearing-driven magnetic relaxation

NASA Astrophysics Data System (ADS)

Sauppe, J. P.; Sovinec, C. R.

2017-05-01

Discrete relaxation events in reversed-field pinch relevant configurations are investigated numerically with nonlinear extended magnetohydrodynamic (MHD) modeling, including the Hall term in Ohm's law and first-order ion finite Larmor radius effects. Results show variability among relaxation events, where the Hall dynamo effect may help or impede the MHD dynamo effect in relaxing the parallel current density profile. The competitive behavior arises from multi-helicity conditions where the dominant magnetic fluctuation is relatively small. The resulting changes in parallel current density and parallel flow are aligned in the core, consistent with experimental observations. The analysis of simulation results also confirms that the force density from fluctuation-induced Reynolds stress arises subsequent to the drive from the fluctuation-induced Lorentz force density. Transport of the momentum density is found to be dominated by the fluctuation-induced Maxwell stress over most of the cross section with viscous and gyroviscous contributions being large in the edge region. The findings resolve a discrepancy with respect to the relative orientation of current density and flow relaxation, which had not been realized or investigated in King et al. [Phys. Plasmas 19, 055905 (2012)], where only the magnitude of flow relaxation is actually consistent with experimental results.

Active and Passive Remote Sensing of Ice.

DTIC Science & Technology

1985-01-01

This is a report on the progress that has been made in the study of active and passive remote sensing of ice during the period of August 1, 1984...active and passive microwave remote sensing , (2) used the strong fluctuation theory and the fluctuation-dissipation theorem to calculate the brightness

A Model for the Epigenetic Switch Linking Inflammation to Cell Transformation: Deterministic and Stochastic Approaches

PubMed Central

Gérard, Claude; Gonze, Didier; Lemaigre, Frédéric; Novák, Béla

2014-01-01

Recently, a molecular pathway linking inflammation to cell transformation has been discovered. This molecular pathway rests on a positive inflammatory feedback loop between NF-κB, Lin28, Let-7 microRNA and IL6, which leads to an epigenetic switch allowing cell transformation. A transient activation of an inflammatory signal, mediated by the oncoprotein Src, activates NF-κB, which elicits the expression of Lin28. Lin28 decreases the expression of Let-7 microRNA, which results in higher level of IL6 than achieved directly by NF-κB. In turn, IL6 can promote NF-κB activation. Finally, IL6 also elicits the synthesis of STAT3, which is a crucial activator for cell transformation. Here, we propose a computational model to account for the dynamical behavior of this positive inflammatory feedback loop. By means of a deterministic model, we show that an irreversible bistable switch between a transformed and a non-transformed state of the cell is at the core of the dynamical behavior of the positive feedback loop linking inflammation to cell transformation. The model indicates that inhibitors (tumor suppressors) or activators (oncogenes) of this positive feedback loop regulate the occurrence of the epigenetic switch by modulating the threshold of inflammatory signal (Src) needed to promote cell transformation. Both stochastic simulations and deterministic simulations of a heterogeneous cell population suggest that random fluctuations (due to molecular noise or cell-to-cell variability) are able to trigger cell transformation. Moreover, the model predicts that oncogenes/tumor suppressors respectively decrease/increase the robustness of the non-transformed state of the cell towards random fluctuations. Finally, the model accounts for the potential effect of competing endogenous RNAs, ceRNAs, on the dynamics of the epigenetic switch. Depending on their microRNA targets, the model predicts that ceRNAs could act as oncogenes or tumor suppressors by regulating the occurrence of cell transformation. PMID:24499937

Time-dependent behavior in a transport-barrier model for the quasi-single helcity state

NASA Astrophysics Data System (ADS)

Terry, P. W.; Whelan, G. G.

2014-09-01

Time-dependent behavior that follows from a recent theory of the quasi-single-helicity (QSH) state of the reversed field pinch is considered. The theory (Kim and Terry 2012 Phys. Plasmas 19 122304) treats QSH as a core fluctuation structure tied to a tearing mode of the same helicity, and shows that strong magnetic and velocity shears in the structure suppress the nonlinear interaction with other fluctuations. By summing the multiple helicity fluctuation energies over wavenumber, we reduce the theory to a predator-prey model. The suppression of the nonlinear interaction is governed by the single helicity energy, which, for fixed radial structure, controls the magnetic and velocity shearing rates. It is also controlled by plasma current which, in the theory, sets the shearing threshold for suppression. The model shows a limit cycle oscillation in which the system toggles between QSH and multiple helicity states, with the single helicity phase becoming increasingly long-lived relative to the multiple helicity phase as plasma current increases.

A combined phase contrast imaging-interferometer system for the detection of multiscale density fluctuations on DIII-D

NASA Astrophysics Data System (ADS)

Davis, E. M.; Rost, J. C.; Porkolab, M.; Marinoni, A.; van Zeeland, M. A.

2016-10-01

A heterodyne interferometer channel has been added to the DIII-D phase contrast imaging (PCI) system. Both measurements share a single 10.6 μm probe beam. Whereas the PCI excels at detecting medium- to high- k fluctuations (1.5 cm-1 <= k <= 20 cm-1), the interferometer extends the system sensitivity to low- k fluctuations (k <= 5 cm-1), allowing simultaneous measurement of electron- and ion-scale instabilities with sub-microsecond resolution. Further, correlating measurements from the interferometer channel with those from DIII-D's pre-existing, toroidally separated interferometer (Δ∅ = 45°) allows identification of low- n modes. This new capability has been corroborated against magnetic measurements and may allow novel investigations of core - localized MHD that is otherwise inaccessible via external magnetic measurements, with potential applications to fast particle transport and disruptions. Work supported by USDOE under DE-FG02-94ER54235, DE-FC02-04ER54698, and DE-FC02-99ER54512.

Negative magnetoresistance of ultra-narrow superconducting nanowires in the resistive state

NASA Astrophysics Data System (ADS)

Arutyunov, K. Yu.

2008-02-01

We present a phenomenological model that qualitatively explains negative magnetoresistance in quasi-one-dimensional superconducting channels in the resistive state. The model is based on the assumption that fluctuations of the order parameter (phase slips) are responsible for the finite effective resistance of a narrow superconducting wire sufficiently close to the critical temperature. Each fluctuation is accompanied by an instantaneous formation of a quasi-normal region, of the order of the non-equilibrium quasiparticle relaxation length, ‘pinned’ to the core of the phase slip. The effective time-averaged voltage measured in experiments is a sum of two terms. The first is the conventional contribution associated with the rate of the fluctuations via the Josephson relation. The second term is the Ohmic contribution of this quasi-normal region. Depending on the material properties of the wire, there might be a range of magnetic fields where the first term is not significantly affected, while the second term is effectively suppressed, contributing to the experimentally observed negative magnetoresistance.

Millimeter-wave reflectometry for electron density profile and fluctuation measurements on NSTX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kubota, S.; Nguyen, X. V.; Peebles, W. A.

2001-01-01

A millimeter-wave reflectometry system for electron density profile and fluctuation measurements is being developed and installed on the National Spherical Torus Experiment. The initial frequency coverage will be in the bands 12--18, 20--32, and 33--50 GHz, provided by frequency-tunable solid-state sources. These frequencies correspond to O-mode cutoff densities ranging from 1.8x10{sup 12} to 3.1x10{sup 13}cm{sup -3}, which will span both the plasma core ({rho}=r/a<0.8) and edge ({rho}>0.8) regions. Operated as a broadband swept-frequency (frequency-modulated continuous-wave) reflectometer, the diagnostic is expected to provide routine (shot-to-shot) time- ({<=}50 {mu}s) and spatially resolved ({approx}1 cm) density profiles. The previous hardware can be easilymore » reconfigured as a fixed-frequency reflectometer for density fluctuation measurements. The combination of measurements would be valuable for studying phenomena such as possible L- to H-mode transitions and edge-localized modes.« less

Flux of a Ratchet Model and Applications to Processive Motor Proteins

NASA Astrophysics Data System (ADS)

Li, Jing-Hui

2015-10-01

In this paper, we investigate the stationary probability current (or flux) of a Brownian ratchet model as a function of the flipping rate of the fluctuating potential barrier. It is shown that, with suitably selecting the parameters' values of the ratchet system, we can get the negative resonant activation, the positive resonant activation, the double resonant activation, and the current reversal, for the stationary probability current versus the flipping rate. The appearance of these phenomena is the result of the cooperative effects of the potential's dichotomous fluctuations and the internal thermal fluctuations on the evolution of the flux versus the flipping rate of the fluctuating potential barrier. In addition, some applications of our results to the motor proteins are discussed. Supported by K.C. Wong Magna Fund in Ningbo University in China

Investigation of Density Fluctuations in Supersonic Free Jets and Correlation with Generated Noise

NASA Technical Reports Server (NTRS)

Panda, J.; Seasholtz, R. G.

2000-01-01

The air density fluctuations in the plumes of fully-expanded, unheated free jets were investigated experimentally using a Rayleigh scattering based technique. The point measuring technique used a continuous wave laser, fiber-optic transmission and photon counting electronics. The radial and centerline profiles of time-averaged density and root-mean-square density fluctuation provided a comparative description of jet growth. To measure density fluctuation spectra a two-Photomultiplier tube technique was used. Crosscorrelation between the two PMT signals significantly reduced electronic shot noise contribution. Turbulent density fluctuations occurring up to a Strouhal number (Sr) of 2.5 were resolved. A remarkable feature of density spectra, obtained from the same locations of jets in 0.5< M<1.5 range, is a constant Strouhal frequency for peak fluctuations. A detailed survey at Mach numbers M = 0.95, 1.4 and 1.8 showed that, in general, distribution of various Strouhal frequency fluctuations remained similar for the three jets. In spite of the similarity in the flow fluctuation the noise characteristics were found to be significantly different. Spark schlieren photographs and near field microphone measurements confirmed that the eddy Mach wave radiation was present in Mach 1.8 jet, and was absent in Mach 0.95 jet. To measure correlation between the flow and the far field sound pressure fluctuations, a microphone was kept at a distance of 50 diameters, 30 deg. to the flow direction, and the laser probe volume was moved from point to point in the flow. The density fluctuations in the peripheral shear layer of Mach 1.8 jet showed significant correlation up to the measurement limit of Sr = 2.5, while for Mach 0.95 jet no correlation was measured. Along the centerline measurable correlation was found from the end of the potential core and at the low frequency range (Sr less than 0.5). Usually the normalized correlation values increased with an increase of the jet Mach number. The experimental data point out eddy Mach waves as a strong source of sound generation in supersonic jets and fail to locate the primary noise mechanism in subsonic jets.

Extreme fluctuations of active Brownian motion

NASA Astrophysics Data System (ADS)

Pietzonka, Patrick; Kleinbeck, Kevin; Seifert, Udo

2016-05-01

In active Brownian motion, an internal propulsion mechanism interacts with translational and rotational thermal noise and other internal fluctuations to produce directed motion. We derive the distribution of its extreme fluctuations and identify its universal properties using large deviation theory. The limits of slow and fast internal dynamics give rise to a kink-like and parabolic behavior of the corresponding rate functions, respectively. For dipolar Janus particles in two- and three-dimensions interacting with a field, we predict a novel symmetry akin to, but different from, the one related to entropy production. Measurements of these extreme fluctuations could thus be used to infer properties of the underlying, often hidden, network of states.

Pollen record of the mid- to late-Holocene centennial climate change on the East coast of South Korea and its influential factors

NASA Astrophysics Data System (ADS)

Song, Bing; Yi, Sangheon; Jia, Hongjuan; Nahm, Wook-Hyun; Kim, Jin-Cheul; Lim, Jaesoo; Lee, Jin-Young; Sha, Longbin; Mao, Limi; Yang, Zhongyong; Nakanishi, Toshimichi; Hong, Wan; Li, Zhen

2018-01-01

To understand historical climate change in western Pacific coastal areas, a sediment core (SOJ-2) from the stable sedimentary environment of the Songjiho Lagoon on the east coast of South Korea was obtained for centennial-resolution palynological analysis. The ages of the SOJ-2 core is well controlled by carbon 14 dating with high-resolution accelerator mass spectrometry (AMS), and the results indicated a general warm to cold climate trend from the mid-Holocene to the present, which can be divided into two different stages: a warmer stage between 6842 and 1297 cal yr BP and a colder stage from 1297 cal yr BP to the present, with fluctuations during these stages. The climate was wetter from 6842 to 6227 cal yr BP and 4520 to 1297 cal yr BP and was drier from 6227 to 4520 cal yr BP. The climate changed to cold and dry during the period from 1297-425 cal yr BP. The impact of human activity on the climate began at approximately 1297 cal yr BP and became pronounced starting in 425 cal yr BP. The general cooling trend may represent a response to decreasing solar insolation; however, the relative dryness or wetness of the climate may have been co-determined by westerlies and the East Asian summer monsoon (EASM). The climate had a teleconnection with the North Atlantic region, resulting from changes in solar activity. Nevertheless, EI Niño-Southern Oscillation (ENSO) activity played an important role in impacting the EASM changes in western Pacific coastal areas.

75 FR 18826 - FPL Energy Maine Hydro LLC, Madison Paper Industries, and Merimil Limited Partnership; Notice of...

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2010-04-13

... fishway (inactive); and (e) a 734-foot earth dike with a concrete core wall; (2) a 9,700-acre reservoir... downstream demands for hydroelectric generation in the Kennebec River and for flood control. Reservoir fluctuations follow an annual cycle under which reservoir levels are reduced during the fall and winter to...

Changing predictions, stable recognition: Children's representations of downward incline motion.

PubMed

Hast, Michael; Howe, Christine

2017-11-01

Various studies to-date have demonstrated children hold ill-conceived expressed beliefs about the physical world such as that one ball will fall faster than another because it is heavier. At the same time, they also demonstrate accurate recognition of dynamic events. How these representations relate is still unresolved. This study examined 5- to 11-year-olds' (N = 130) predictions and recognition of motion down inclines. Predictions were typically in error, matching previous work, but children largely recognized correct events as correct and rejected incorrect ones. The results also demonstrate while predictions change with increasing age, recognition shows signs of stability. The findings provide further support for a hybrid model of object representations and argue in favour of stable core cognition existing alongside developmental changes. Statement of contribution What is already known on this subject? Children's predictions of physical events show limitations in accuracy Their recognition of such events suggests children may use different knowledge sources in their reasoning What the present study adds? Predictions fluctuate more strongly than recognition, suggesting stable core cognition But recognition also shows some fluctuation, arguing for a hybrid model of knowledge representation. © 2017 The British Psychological Society.

Te and H_α Measurements on the HT-7 Tokamak: A Collaboration between the Fusion Research Center and the Institute of Plasma Physics

NASA Astrophysics Data System (ADS)

Winslow, D. L.; Carter, K. R.; Chatterjee, R.; Huang, H.; Phillips, P. E.; Rowan, W. L.; Kuang, G. L.; Li, J. G.; Luo, J. R.; Wan, B. N.; Wan, Y. X.; Xie, J. K.

1998-11-01

A team from the Fusion Research Center at the University of Texas at Austin visited the HT-7 Tokamak at the Institute of Plasma Physics at the Chinese Academy of Sciences in Hefei, Anhui, China to study the effects of lower hybrid current drive (LHCD) in the HT-7 plasma. HT-7(HT-7 Group, Fusion Energy 1996 Vol. 1, 685 (1997).) is a medium-sized (R = 1.22 m) tokamak with superconducting toroidal field coils and long--pulse capabilities utilizing LHCD to assist ohmic current drive. Core and edge diagnostics supported by a stand-alone data acquisition system were installed for the spring 1998 campaign. The diagnostics included an ECE radiometer which allows determination of both electron temperature profiles and fluctuation levels in the core plasma and an H_α array detector for measurement of turbulence in regions not easily accessible to probes. In addition, a reciprocating Langmuir probe system was developed for use on HT-7 and should be available for the next campaign. The effects of LHCD upon fluctuation levels in the plasma will be discussed.

ELM elimination with lithium aerosol injection in upper-single null discharges using the tungsten divertor in EAST

NASA Astrophysics Data System (ADS)

Sun, Z.; Maingi, R.; Hu, J.; Lunsford, R.; Diallo, A.; Tritz, K.; Osborne, T.; Canik, J.; Zuo, G.; Wang, L.; Xu, G.; Gong, X.; EAST Team Team

2017-10-01

A reproducible, fully non-inductive H-mode regime devoid of large ELMs has been achieved by continuous Li injection in EAST into the upper `ITER-like' tungsten divertor, extending previous results on the graphite divertor. These discharges did not suffer from density or impurity accumulation, and maintained constant core radiated power. The new results extend the energy confinement multiplier H98(y,2) 1.2, as compared to H98(y,2) 0.75 previously on the graphite divertor. The observed ELM elimination is correlated with a decrease in particle recycling, as expected from the strong Li coating before the experiment, and real-time Li aerosol injection. In addition, core W concentration was reduced during the Li injection. ELM elimination is likely related to the reduced recycling and density /temperature profile changes. A low-n electromagnetic coherent mode (MCM) at 40kHz became stronger in amplitude and also more coherent. The MCM shows strong magnetic fluctuations as measured by fast Mirnov coils, but weak density fluctuations. As compared to the graphite divertor, Li injection into the tungsten divertor eliminated ELMs at twice the previous auxiliary heating power, and reduced pedestal collisionality.

Measurement of energy muons in EAS at energy region larger thean 10(17) eV

NASA Technical Reports Server (NTRS)

Matsubara, Y.; Hara, T.; Hayashida, N.; Kamata, K.; Nagano, M.; Ohoka, H.; Tanahasni, G.; Teshima, T.

1985-01-01

A measurement of low energy muons in extensive air showers (EAS) (threshold energies are 0.25, 0.5, 0.75 and 1.38 GeV) was carried out. The density under the concrete shielding equivalent to 0.25 GeV at core distance less than 500 m and 0.5 GeV less than 150 m suffers contamination of electromagnetic components. Therefore the thickness of concrete shielding for muon detectors for the giant air shower array is determined to be 0.5 GeV equivalence. Effects of photoproduced muons are found to be negligible in the examined ranges of shower sizes and core distances. The fluctuation of the muon density in 90 sq m is at most 25% between 200 m and 600 m from the core around 10 to the 17th power eV.

Gravitational lensing in a cold dark matter universe

NASA Technical Reports Server (NTRS)

Narayan, Ramesh; White, Simon D. M.

1988-01-01

Gravitational lensing due to mass condensations in a biased cold dark matter (CDM) universe is investigated using the Press-Schechter (1974) theory with density fluctuation amplitudes taken from previous N-body work. Under the critical assumption that CDM haloes have small core radii, a distribution of image angular separations for high-z lensed quasars with a peak at about 1 arcsec and a half-width of a factor of about 10. Allowing for selection effects at small angular separations, this is in good agreement with the observed separations. The estimated frequency of lensing is somewhat lower than that observed, but the discrepancy can be removed by invoking amplification bias and by making a small upward adjustment to the density fluctuation amplitudes assumed in the CDM model.

Memory traces of long-range coordinated oscillations in the sleeping human brain.

PubMed

Piantoni, Giovanni; Van Der Werf, Ysbrand D; Jensen, Ole; Van Someren, Eus J W

2015-01-01

Cognition involves coordinated activity across distributed neuronal networks. Neuronal activity during learning triggers cortical plasticity that allows for reorganization of the neuronal network and integration of new information. Animal studies have shown post-learning reactivation of learning-elicited neuronal network activity during subsequent sleep, supporting consolidation of the reorganization. However, no previous studies, to our knowledge, have demonstrated reactivation of specific learning-elicited long-range functional connectivity during sleep in humans. We here show reactivation of learning-induced long-range synchronization of magnetoencephalography power fluctuations in human sleep. Visuomotor learning elicited a specific profile of long-range cortico-cortical synchronization of slow (0.1 Hz) fluctuations in beta band (12-30 Hz) power. The parieto-occipital part of this synchronization profile reappeared in delta band (1-3.5 Hz) power fluctuations during subsequent sleep, but not during the intervening wakefulness period. Individual differences in the reactivated synchronization predicted postsleep performance improvement. The presleep resting-state synchronization profile was not reactivated during sleep. The findings demonstrate reactivation of long-range coordination of neuronal activity in humans, more specifically of reactivation of coupling of infra-slow fluctuations in oscillatory power. The spatiotemporal profile of delta power fluctuations during sleep may subserve memory consolidation by echoing coordinated activation elicited by prior learning. © 2014 Wiley Periodicals, Inc.

An RXTE Study of M87 and the Core of the Virgo Cluster

NASA Technical Reports Server (NTRS)

Reynolds, Christopher S.; Heinz, Sebastian; Fabian, Andrew C.; Begelman, Mitchell C.

1998-01-01

We present hard X-ray observations of the nearby radio galaxy M87 and the core of the Virgo cluster using the Rossi X-ray Timing Explorer. These are the first hard X-ray observations of M87 not affected by contamination from the nearby Seyfert 2 galaxy NGC 4388. Thermal emission from Virgo's intracluster medium is clearly detected and has a spectrum indicative of kT approx. = 2.5 keV plasma with approximately 25% cosmic abundances. No non-thermal (power-law) emission from M87 is detected in the hard X-ray band, with fluctuations in the Cosmic X-ray Background being the limiting factor. Combining with ROSAT data, we infer that the X-ray spectrum of the M87 core and jet must be steep (Gamma(sub core) greater than 1.90 and Gamma(sub jet) greater than 1.75), and we discuss the implications of this result. In particular, these results are consistent with M87 being a mis-aligned BL-Lac object.

Reconstructed plutonium fallout in the GV7 firn core from Northern Victoria Land, East Antarctica

NASA Astrophysics Data System (ADS)

Hwang, H.; Han, Y.; Kang, J.; Lee, K.; Hong, S.; Hur, S. D.; Narcisi, B.; Frezzotti, M.

2017-12-01

Atmospheric nuclear explosions during the period from the 1940s to the 1980s are the major anthropogenic source of plutonium (Pu) in the environment. In this work, we analyzed fg g-1 levels of artificial Pu, released predominantly by atmospheric nuclear weapons tests. We measured 351 samples which collected a 78 m-depth fire core at the site of GV7 (S 70°41'17.1", E 158°51'48.9", 1950 m a.s.l.), Northern Victoria Land, East Antarctica. To determine the Pu concentration in the samples, we used an inductively coupled plasma sector field mass spectrometry coupled with an Apex high-efficiency sample introduction system, which has the advantages of small sample consumption and simple sample preparation. We reconstructed the firn core Pu fallout record for the period after 1954 CE shows a significant fluctuation in agreement with past atmospheric nuclear testing. These data will contribute to ice core research by providing depth-age information.

An RXTE Study of M87 and the Core of the Virgo Cluster

NASA Technical Reports Server (NTRS)

Reynolds, Christopher S.; Heinz, Sebastian; Fabian, Andrew C.; Begelman, Mitchell C.

1998-01-01

We present hard X-ray observations of the nearby radio galaxy M87 and the core of the Virgo cluster using the Rossi X-ray 7Tming Explorer. These are the first hard X-ray observations of M87 not affected by contamination from the nearby Seyfert 2 galaxy NGC 4388. Thermal emission from Virgo's intracluster medium is clearly detected and has a spectrum indicative of kT is approximately equal to 2.5 keV plasma with approximately 25% cosmic abundances. No non-thermal (power-law) emission from M87 is detected in the hard X-ray band, with fluctuations in the Cosmic X-ray Background being the limiting factor. Combining with ROSAT data, we infer that the X-ray spectrum of the M87 core and jet must be steep (Gamma (sub core) > 1.90 and Gamma (sub jet) > 1.75), and we discuss the implications of this result. In particular, these results are consistent with M87 being a mis-aligned BL-Lac object.

Fluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state Experience Sampling Method.

PubMed

Van Calster, Laurens; D'Argembeau, Arnaud; Salmon, Eric; Peters, Frédéric; Majerus, Steve

2017-01-01

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top-down versus bottom-up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes.

Fluctuation reduction and enhanced confinement in the MST reversed-field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapman, Brett Edward

1997-10-01

Plasmas with a factor of ≥3 improvement in energy confinement have been achieved in the MST reversed-field pinch (RFP). These plasmas occur spontaneously, following sawtooth crashes, subject to constraints on, eg, toroidal magnetic field reversal and wall conditioning. Possible contributors to the improved confinement include a reduction of core-resonant, global magnetic fluctuations and a reduction of electrostatic fluctuations over the entire plasma edge. One feature of these plasmas is a region of strong ExB flow shear in the edge. Never before observed in conjunction with enhanced confinement in the RFP, such shear is common in enhanced confinement discharges in tokamaks and stellarators. Another feature of these plasmas is a new type of discrete dynamo event. Like sawtooth crashes, a common form of discrete dynamo, these events correspond to bursts of edge parallel current. The reduction of electrostatic fluctuations in these plasmas occurs within and beyond the region of strong ExB flow shear, similar to what is observed in tokamaks and stellarators. However, the reductions in the MST include fluctuations whose correlation lengths are larger than the width of the shear region. The reduction of the global magnetic fluctuations is most likely due to flattening of the μ=μ 0more » $$\\vec{J}$$∙$$\\vec{B}$$/B 2 profile. Flattening can occur, eg, due to the new type of discrete dynamo event and reduced edge resistivity. Enhanced confinement plasmas are also achieved in the MST when auxiliary current is applied to flatten the μ profile and reduce magnetic fluctuations. Unexpectedly, these plasmas also exhibit a region (broader than in the case above) of strong ExB flow shear in the edge, an edge-wide reduction of electrostatic fluctuations, and the new type of discrete dynamo event. Auxiliary current drive has historically been viewed as the principal route to fusion reactor viability for the RFP.« less

Late Quaternary palaeoenvironmental reconstruction of sediment drift accumulation in the Malta Graben (central Mediterranean Sea)

NASA Astrophysics Data System (ADS)

Ferraro, Serena; Sulli, Attilio; Di Stefano, Enrico; Giaramita, Luigi; Incarbona, Alessandro; Graham Mortyn, P.; Sprovieri, Mario; Sprovieri, Rodolfo; Tonielli, Renato; Vallefuoco, Mattia; Zizzo, Elisabetta; Tranchida, Giorgio

2018-06-01

The Malta Graben is a deep tectonic depression in the Sicily Channel, bounded by NW-SE normal faults and filled by thick Pliocene-Quaternary deposits. A previous analysis of a giant piston core (LC09) from the Malta Graben had revealed a wide range of sedimentary features (carbonate turbidites, bioturbated mud and scours), although the chronostratigraphic constraint of the stacking pattern has remained elusive. After establishing a reliable chronological framework based on seven radiocarbon dates for a shorter core from the Malta Graben (ANSIC03-735), a down-core analysis of planktonic foraminifer and coccolith abundance, stable isotopes and sediment grain size was carried out. Since the last glacial maximum, palaeoenvironmental conditions (surface fertility and deep chlorophyll maximum during the last glacial and the Younger Dryas; warm and oligotrophic water masses, with a deep nutricline and intense winter mixing during the Holocene) as well as selected calcareous plankton taxa trends and peaks seem to be similar to those reported for other central and western Mediterranean sites, possibly in spite of a unique response of these areas to late Quaternary climatic fluctuations. Four distinct layers, each tens of centimetres thick, are barren of foraminifers but not of coccoliths. Morphobathymetric data as well as new high-resolution and high-penetration seismic profiles show that prolonged contouritic activity has persisted on the western side of the Malta Graben. It is thus likely that layers barren of foraminifers are due to the overflow of fine-grained (clayey) material beyond drift channel dikes.

Late Quaternary palaeoenvironmental reconstruction of sediment drift accumulation in the Malta Graben (central Mediterranean Sea)

NASA Astrophysics Data System (ADS)

Ferraro, Serena; Sulli, Attilio; Di Stefano, Enrico; Giaramita, Luigi; Incarbona, Alessandro; Graham Mortyn, P.; Sprovieri, Mario; Sprovieri, Rodolfo; Tonielli, Renato; Vallefuoco, Mattia; Zizzo, Elisabetta; Tranchida, Giorgio

2018-03-01

The Malta Graben is a deep tectonic depression in the Sicily Channel, bounded by NW-SE normal faults and filled by thick Pliocene-Quaternary deposits. A previous analysis of a giant piston core (LC09) from the Malta Graben had revealed a wide range of sedimentary features (carbonate turbidites, bioturbated mud and scours), although the chronostratigraphic constraint of the stacking pattern has remained elusive. After establishing a reliable chronological framework based on seven radiocarbon dates for a shorter core from the Malta Graben (ANSIC03-735), a down-core analysis of planktonic foraminifer and coccolith abundance, stable isotopes and sediment grain size was carried out. Since the last glacial maximum, palaeoenvironmental conditions (surface fertility and deep chlorophyll maximum during the last glacial and the Younger Dryas; warm and oligotrophic water masses, with a deep nutricline and intense winter mixing during the Holocene) as well as selected calcareous plankton taxa trends and peaks seem to be similar to those reported for other central and western Mediterranean sites, possibly in spite of a unique response of these areas to late Quaternary climatic fluctuations. Four distinct layers, each tens of centimetres thick, are barren of foraminifers but not of coccoliths. Morphobathymetric data as well as new high-resolution and high-penetration seismic profiles show that prolonged contouritic activity has persisted on the western side of the Malta Graben. It is thus likely that layers barren of foraminifers are due to the overflow of fine-grained (clayey) material beyond drift channel dikes.

Study of the Molecular Dynamics of Multiarm Star Polymers with a Poly(ethyleneimine) Core and Poly(lactide) Multiarms

PubMed Central

Román, Frida; Colomer, Pere; Calventus, Yolanda; Hutchinson, John M.

2017-01-01

Multiarm star polymers, denoted PEIx-PLAy and containing a hyperbranched poly(ethyleneimine) (PEI) core of different molecular weights x and poly(lactide) (PLA) arms with y ratio of lactide repeat units to N links were used in this work. Samples were preconditioned to remove the moisture content and then characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and dielectric relaxation spectroscopy (DRS). The glass transition temperature, Tg, is between 48 and 50 °C for all the PEIx-PLAy samples. The dielectric curves show four dipolar relaxations: γ, β, α, and α′ in order of increasing temperature. The temperatures at which these relaxations appear, together with their dependence on the frequency, allows relaxation maps to be drawn, from which the activation energies of the sub-Tg γ- and β-relaxations and the Vogel–Fulcher–Tammann parameters of the α-relaxation glass transition are obtained. The dependence of the characteristic features of these relaxations on the molecular weight of the PEI core and on the ratio of lactide repeat units to N links permits the assignation of molecular motions to each relaxation. The γ-relaxation is associated with local motions of the –OH groups of the poly(lactide) chains, the β-relaxation with motions of the main chain of poly(lactide), the α-relaxation with global motions of the complete assembly of PEI core and PLA arms, and the α′-relaxation is related to the normal mode relaxation due to fluctuations of the end-to-end vector in the PLA arms, without excluding the possibility that it could be a Maxwell–Wagner–Sillars type ionic peak because the material may have nano-regions of different conductivity. PMID:28772486

Glaciochemical investigation of an ice core from Belukha Glacier,Siberian Altai

NASA Astrophysics Data System (ADS)

Olivier, S.; Schwikowski, S.; Gäggeler, H. W.; Lüthi, M.; Eyrik, S.; Blaser, C.; Saurer, M.; Schotterer, U.

2003-04-01

Little is known about climatic change and paleo-atmospheric composition in Siberia. The Altai is the only alpine region in this area covered by glaciers that might serve as archives for such studies. Moreover, it is located close to air pollution sources in East Kazakhstan and South Siberia (heavy metal mining, metallurgy) as well as to the nuclear test site of Semipalatinsk (release of radionuclides into the atmosphere). In order to reconstruct air pollution levels in the Altai region, a 140-meter ice core down to bedrock was recovered from the Belukha glacier (N49^o48'26", E86^o34'43", 4062 m asl) in July 2001. This site was selected based on the results of an exploratory study conducted in 2000. So far, the concentrations of major ionic species and the stable isotope ratio δ18O were determined in the approx. 90 topmost meters of the ice core covering about 200 years. Dating of the upper part of the ice core was performed by a combination of methods that include e.g. nuclear techniques and annual-layer counting. The annual net accumulation amounts to about 0.53 m weq. and indicates that snow at the Belukha glacier might be partly eroded by wind, a situation that is often observed for a glacier saddle. The borehole temperature (-16 ^oC at 80 m depth), the discernible fluctuations of the stable isotope and chemistry records as well as the linearity of the decrease of the log. 210Pb activities with depth indicate that the glaciochemical record is well preserved and not significantly altered by melting processes. In pre-industrial ice concentrations of carboxylic acids and ammonium are high, suggesting the surrounding forest as source of biogenic emissions.

Study of the Molecular Dynamics of Multiarm Star Polymers with a Poly(ethyleneimine) Core and Poly(lactide) Multiarms.

PubMed

Román, Frida; Colomer, Pere; Calventus, Yolanda; Hutchinson, John M

2017-02-04

Multiarm star polymers, denoted PEI x -PLA y and containing a hyperbranched poly(ethyleneimine) (PEI) core of different molecular weights x and poly(lactide) (PLA) arms with y ratio of lactide repeat units to N links were used in this work. Samples were preconditioned to remove the moisture content and then characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and dielectric relaxation spectroscopy (DRS). The glass transition temperature, T g , is between 48 and 50 °C for all the PEI x -PLA y samples. The dielectric curves show four dipolar relaxations: γ, β, α, and α' in order of increasing temperature. The temperatures at which these relaxations appear, together with their dependence on the frequency, allows relaxation maps to be drawn, from which the activation energies of the sub- T g γ- and β-relaxations and the Vogel-Fulcher-Tammann parameters of the α-relaxation glass transition are obtained. The dependence of the characteristic features of these relaxations on the molecular weight of the PEI core and on the ratio of lactide repeat units to N links permits the assignation of molecular motions to each relaxation. The γ-relaxation is associated with local motions of the -OH groups of the poly(lactide) chains, the β-relaxation with motions of the main chain of poly(lactide), the α-relaxation with global motions of the complete assembly of PEI core and PLA arms, and the α'-relaxation is related to the normal mode relaxation due to fluctuations of the end-to-end vector in the PLA arms, without excluding the possibility that it could be a Maxwell-Wagner-Sillars type ionic peak because the material may have nano-regions of different conductivity.

Noise characterization of a pulse train generated by actively mode-locked lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eliyahu, D.; Salvatore, R.A.; Yariv, A.

1996-07-01

We analyze the entire power spectrum of pulse trains generated by a continuously operating actively mode-locked laser in the presence of noise. We consider the effect of amplitude, pulse-shape, and timing-jitter fluctuations that are characterized by stationary processes. Effects of correlations between different parameters of these fluctuations are studied also. The nonstationary timing-jitter fluctuations of passively mode-locked lasers and their influence on the power spectrum is discussed as well. {copyright} {ital 1996 Optical Society of America.}

Maximal Fluctuations of Confined Actomyosin Gels: Dynamics of the Cell Nucleus.

PubMed

Rupprecht, J-F; Singh Vishen, A; Shivashankar, G V; Rao, M; Prost, J

2018-03-02

We investigate the effect of stress fluctuations on the stochastic dynamics of an inclusion embedded in a viscous gel. We show that, in nonequilibrium systems, stress fluctuations give rise to an effective attraction towards the boundaries of the confining domain, which is reminiscent of an active Casimir effect. We apply this generic result to the dynamics of deformations of the cell nucleus, and we demonstrate the appearance of a fluctuation maximum at a critical level of activity, in agreement with recent experiments [E. Makhija, D. S. Jokhun, and G. V. Shivashankar, Proc. Natl. Acad. Sci. U.S.A. 113, E32 (2016)PNASA60027-842410.1073/pnas.1513189113].

Measurement and Analysis of Structural Integrity of Reactor Core Support Structure in Pressurized Water Reactor (PWR) Plant

NASA Astrophysics Data System (ADS)

Ansari, Saleem A.; Haroon, Muhammad; Rashid, Atif; Kazmi, Zafar

2017-02-01

Extensive calculation and measurements of flow-induced vibrations (FIV) of reactor internals were made in a PWR plant to assess the structural integrity of reactor core support structure against coolant flow. The work was done to meet the requirements of the Fukushima Response Action Plan (FRAP) for enhancement of reactor safety, and the regulatory guide RG-1.20. For the core surveillance measurements the Reactor Internals Vibration Monitoring System (IVMS) has been developed based on detailed neutron noise analysis of the flux signals from the four ex-core neutron detectors. The natural frequencies, displacement and mode shapes of the reactor core barrel (CB) motion were determined with the help of IVMS. The random pressure fluctuations in reactor coolant flow due to turbulence force have been identified as the predominant cause of beam-mode deflection of CB. The dynamic FIV calculations were also made to supplement the core surveillance measurements. The calculational package employed the computational fluid dynamics, mode shape analysis, calculation of power spectral densities of flow & pressure fields and the structural response to random flow excitation forces. The dynamic loads and stiffness of the Hold-Down Spring that keeps the core structure in position against upward coolant thrust were also determined by noise measurements. Also, the boron concentration in primary coolant at any time of the core cycle has been determined with the IVMS.

The Effect of Birthrate Granularity on the Release- to- Birth Ratio for the AGR-1 In-core Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dawn Scates; John Walter

The AGR-1 Advanced Gas Reactor (AGR) tristructural-isotropic-particle fuel experiment underwent 13 irradiation intervals from December 2006 until November 2009 within the Idaho National Laboratory Advanced Test Reactor in support of the Next Generation Nuclear Power Plant program. During this multi-year experiment, release-to-birth rate ratios were computed at the end of each operating interval to provide information about fuel performance. Fission products released during irradiation were tracked daily by the Fission Product Monitoring System using 8-hour measurements. Birth rates calculated by MCNP with ORIGEN for as-run conditions were computed at the end of each irradiation interval. Each time step in MCNPmore » provided neutron flux, reaction rates and AGR-1 compact composition, which were used to determine birth rates using ORIGEN. The initial birth-rate data, consisting of four values for each irradiation interval at the beginning, end, and two intermediate times, were interpolated to obtain values for each 8-hour activity. The problem with this method is that any daily changes in heat rates or perturbations, such as shim control movement or core/lobe power fluctuations, would not be reflected in the interpolated data and a true picture of the system would not be presented. At the conclusion of the AGR-1 experiment, great efforts were put forth to compute daily birthrates, which were reprocessed with the 8-hour release activity. The results of this study are presented in this paper.« less

The effect of birthrate granularity on the release-to-birth ratio for the AGR-1 in-core experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

D. M. Scates; J. B. Walter; J. T. Maki

The AGR-1 Advanced Gas Reactor (AGR) tristructural-isotropic-particle fuel experiment underwent 13 irradiation intervals from December 2006 until November 2009 within the Idaho National Laboratory Advanced Test Reactor in support of the Next Generation Nuclear Power Plant program. During this multi-year experiment, release-to-birth rate ratios were computed at the end of each operating interval to provide information about fuel performance. Fission products released during irradiation were tracked daily by the Fission Product Monitoring System using 8-h measurements. Birth rate calculated by MCNP with ORIGEN for as-run conditions were computed at the end of each irradiation interval. Each time step in MCNPmore » provided neutron flux, reaction rates and AGR-1 compact composition, which were used to determine birth rate using ORIGEN. The initial birth-rate data, consisting of four values for each irradiation interval at the beginning, end, and two intermediate times, were interpolated to obtain values for each 8-h activity. The problem with this method is that any daily changes in heat rates or perturbations, such as shim control movement or core/lobe power fluctuations, would not be reflected in the interpolated data and a true picture of the system would not be presented. At the conclusion of the AGR-1 experiment, great efforts were put forth to compute daily birthrates, which were reprocessed with the 8-h release activity. The results of this study are presented in this paper.« less

Non-Gaussian limit fluctuations in active swimmer suspensions

NASA Astrophysics Data System (ADS)

Kurihara, Takashi; Aridome, Msato; Ayade, Heev; Zaid, Irwin; Mizuno, Daisuke

2017-03-01

We investigate the hydrodynamic fluctuations in suspensions of swimming microorganisms (Chlamydomonas) by observing the probe particles dispersed in the media. Short-term fluctuations of probe particles were superdiffusive and displayed heavily tailed non-Gaussian distributions. The analytical theory that explains the observed distribution was derived by summing the power-law-decaying hydrodynamic interactions from spatially distributed field sources (here, swimming microorganisms). The summing procedure, which we refer to as the physical limit operation, is applicable to a variety of physical fluctuations to which the classical central limiting theory does not apply. Extending the analytical formula to compare to experiments in active swimmer suspensions, we show that the non-Gaussian shape of the observed distribution obeys the analytic theory concomitantly with independently determined parameters such as the strength of force generations and the concentration of Chlamydomonas. Time evolution of the distributions collapsed to a single master curve, except for their extreme tails, for which our theory presents a qualitative explanation. Investigations thereof and the complete agreement with theoretical predictions revealed broad applicability of the formula to dispersions of active sources of fluctuations.

Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex

PubMed Central

Nir, Yuval; Mukamel, Roy; Dinstein, Ilan; Privman, Eran; Harel, Michal; Fisch, Lior; Gelbard-Sagiv, Hagar; Kipervasser, Svetlana; Andelman, Fani; Neufeld, Miri Y; Kramer, Uri; Arieli, Amos; Fried, Itzhak; Malach, Rafael

2009-01-01

Animal studies have shown robust electrophysiological activity in the sensory cortex in the absence of stimuli or tasks. Similarly, recent human functional magnetic resonance imaging (fMRI) revealed widespread, spontaneously emerging cortical fluctuations. However, it is unknown what neuronal dynamics underlie this spontaneous activity in the human brain. Here we studied this issue by combining bilateral single-unit, local field potentials (LFPs) and intracranial electrocorticography (ECoG) recordings in individuals undergoing clinical monitoring. We found slow (<0.1 Hz, following 1/f-like profiles) spontaneous fluctuations of neuronal activity with significant interhemispheric correlations. These fluctuations were evident mainly in neuronal firing rates and in gamma (40–100 Hz) LFP power modulations. Notably, the interhemispheric correlations were enhanced during rapid eye movement and stage 2 sleep. Multiple intracranial ECoG recordings revealed clear selectivity for functional networks in the spontaneous gamma LFP power modulations. Our results point to slow spontaneous modulations in firing rate and gamma LFP as the likely correlates of spontaneous fMRI fluctuations in the human sensory cortex. PMID:19160509

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

PubMed Central

Iversen, Lars; Tu, Hsiung-Lin; Lin, Wan-Chen; Christensen, Sune M.; Abel, Steven M.; Iwig, Jeff; Wu, Hung-Jen; Gureasko, Jodi; Rhodes, Christopher; Petit, Rebecca S.; Hansen, Scott D.; Thill, Peter; Yu, Cheng-Han; Stamou, Dimitrios; Chakraborty, Arup K.; Kuriyan, John; Groves, Jay T.

2014-01-01

Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS molecules catalyzing nucleotide exchange in H-Ras. Single-molecule kinetic traces revealed that SOS samples a broad distribution of turnover rates through stochastic fluctuations between distinct, long-lived (more than 100 seconds), functional states. The expected allosteric activation of SOS by Ras–guanosine triphosphate (GTP) was conspicuously absent in the mean rate. However, fluctuations into highly active states were modulated by Ras-GTP. This reveals a mechanism in which functional output may be determined by the dynamical spectrum of rates sampled by a small number of enzymes, rather than the ensemble average. PMID:24994643

Witnessing the formation of a radio halo

NASA Astrophysics Data System (ADS)

Kraft, Ralph

2017-09-01

We propose a 200 ks GO observation which would be joined with a 100 ks GTO observation of Abell 2219. The key aims of this proposal are to; provide constraints on particle acceleration at the identified shock fronts; relate the spectral index variations in the radio halo to the surface brightness fluctuations of the X-ray gas; and, characterize the properties of the disrupted sub-cluster core.

Middle to late Holocene fluctuations of the Vindue glacier, an outlet glacier of the Greenland Ice Sheet, central East Greenland.

NASA Astrophysics Data System (ADS)

Levy, L.; Hammer, S. K.; Kelly, M. A.; Lowell, T. V.; Hall, B. L.; Howley, J. A.; Wilcox, P.; Medford, A.

2014-12-01

The margins of the Greenland Ice Sheet are currently responding to present-day climate changes. Determining how the ice sheet margins have responded to past climate changes provides a means to understand how they may respond in the future. Here we present a multi-proxy record used to reconstruct the Holocene fluctuations of the Vindue glacier, an ice sheet outlet glacier in eastern Greenland. Lake sediment cores from Qiviut lake (informal name), located ~0.75 km from the present-day Vindue glacier margin contain a sharp transition from medium sand/coarse silt to laminated gyttja just prior to 6,340±130 cal yr BP. We interpret this transition to indicate a time when the Vindue glacier retreated sufficiently to cease glacial sedimentation into the lake basin. Above this contact the core contains laminated gyttja with prominent, ~0.5 cm thick, silt layers. 10Be ages of boulders on bedrock located between Qiviut lake and the present-day ice margin date to 6.81 ± 0.67 ka (n = 3), indicating the time of deglaciation. These ages also agree well with the radiocarbon age of the silt-gyttja transition in Qiviut lake cores. 10Be ages on boulders on bedrock located more proximal to the ice margin (~0.5 km) yield ages of 2.67 ± 0.18 ka (n = 2). These ages indicate either the continued recession of the ice margin during the late Holocene or an advance at this time. Boulders on the historical moraines show that ice retreated from the moraine by AD 1620 ± 20 yrs (n = 2). These results are in contrast with some areas of the western margin of the ice sheet where 10Be ages indicate that the ice sheet was behind its Historical limit from the middle Holocene (~6-7 ka) to Historical time. This may indicate that the eastern margin may have responded to late Holocene cooling more sensitively or that the advance associated with the Historical moraines overran any evidence of late Holocene fluctuations along the western margin of the ice sheet.

Source of the Organic Matter and Land-Marine Interaction Phases in Great Rann of Kachch Basin, India

NASA Astrophysics Data System (ADS)

Khonde, N. N.; Bhushan, R.; Agnihotri, R.; Maurya, D. M.; Chamyal, L. S.

2017-12-01

Using δ13C and C/N ratio of sedimentary organic matter (OM) in 14C AMS dated sediment core from central Great Rann of Kachchh (GRK) basin, we track sediment dispositional history since 18 ka BP. Temporal changes in the δ13C and C/N ratios were inferred in terms of OM source, which could be function of river discharge, relative sea level changes, and also due to land-cover changes in the catchment area. The down core variations in TOC vs TC doesn't show significant correlation suggesting diverse origin of the OM in GRK sediments. Between 18-13 ka BP, pulses of high C/N ratio (18-34) and depleted δ13C (average -23‰; with respect to typical marine -21‰) values hint terrestrially derived OM in rather overall marine environment. High terrestrial OM input from riverine inputs in post glacial period could be relatable to intense monsoonal conditions. Later to this phase, between 14-10 ka BP, C/N ratios show large fluctuations indicating rapidly fluctuating environment, albeit δ13C remains relatively stable at -21‰ typical of marine OM. A significant positive incursion in C/N ratio (45-60) is seen during early-mid Holocene time ( 10-6 ka BP) with and highly depleted δ13C ( -25‰) values indicating enhanced terrestrial OM input. This could be owing to increased riverine fluxes to the basin under intensified monsoonal climate. Between 6-2.5 ka BP during mid-Holocene, C/N ratios shows declining trend with enriched δ13C values, suggesting presence of marine OM source at the core-site. This overlaps with the weaker monsoonal conditions prevailing in the northwest India. Lake records from Rajasthan also support this contention. After 2.5 ka BP, C/N ratios indicate marine OM values, whereas δ13C fluctuates from marine to terrestrial values indicating `mixed-source' of the OM during this period, most likely due to unstable land-marine conditions and large-scale reworking of sediments.

Nonlinear Upshift of Trapped Electron Mode Critical Density Gradient: Simulation and Experiment

NASA Astrophysics Data System (ADS)

Ernst, D. R.

2012-10-01

A new nonlinear critical density gradient for pure trapped electron mode (TEM) turbulence increases strongly with collisionality, saturating at several times the linear threshold. The nonlinear TEM threshold appears to limit the density gradient in new experiments subjecting Alcator C-Mod internal transport barriers to modulated radio-frequency heating. Gyrokinetic simulations show the nonlinear upshift of the TEM critical density gradient is associated with long-lived zonal flow dominated states [1]. This introduces a strong temperature dependence that allows external RF heating to control TEM turbulent transport. During pulsed on-axis heating of ITB discharges, core electron temperature modulations of 50% were produced. Bursts of line-integrated density fluctuations, observed on phase contrast imaging, closely follow modulations of core electron temperature inside the ITB foot. Multiple edge fluctuation measurements show the edge response to modulated heating is out of phase with the core response. A new limit cycle stability diagram shows the density gradient appears to be clamped during on-axis heating by the nonlinear TEM critical density gradient, rather than by the much lower linear threshold. Fluctuation wavelength spectra will be quantitatively compared with nonlinear TRINITY/GS2 gyrokinetic transport simulations, using an improved synthetic diagnostic. In related work, we are implementing the first gyrokinetic exact linearized Fokker Planck collision operator [2]. Initial results show short wavelength TEMs are fully stabilized by finite-gyroradius collisional effects for realistic collisionalities. The nonlinear TEM threshold and its collisionality dependence may impact predictions of density peaking based on quasilinear theory, which excludes zonal flows.[4pt] In collaboration with M. Churchill, A. Dominguez, C. L. Fiore, Y. Podpaly, M. L. Reinke, J. Rice, J. L. Terry, N. Tsujii, M. A. Barnes, I. Bespamyatnov, R. Granetz, M. Greenwald, A. Hubbard, J. W. Hughes, M. Landreman, B. Li, Y. Ma, P. Phillips, M. Porkolab, W. Rowan, S. Wolfe, and S. Wukitch.[4pt] [1] D. R. Ernst et al., Proc. 21st IAEA Fusion Energy Conference, Chengdu, China, paper IAEA-CN-149/TH/1-3 (2006). http://www-pub.iaea.org/MTCD/Meetings/FEC200/th1-3.pdf[0pt] [2] B. Li and D.R. Ernst, Phys. Rev. Lett. 106, 195002 (2011).

Does High Plasma-β Dynamics ``Load'' Active Regions?

NASA Astrophysics Data System (ADS)

McIntosh, Scott W.

2007-03-01

Using long-duration observations in the He II 304 Å passband of SOHO EIT, we investigate the spatial and temporal appearance of impulsive intensity fluctuations in the pixel light curves. These passband intensity fluctuations come from plasma emitting in the chromosphere, in the transition region, and in the lowest portions of the corona. We see that they are spatially tied to the supergranular scale and that their rate of occurrence is tied to the unsigned imbalance of the magnetic field in which they are observed. The signature of the fluctuations (in space and time) is consistent with their creation by magnetoconvection-forced reconnection, which is driven by the flow field in the high-β plasma. The signature of the intensity fluctuations around an active region suggests that the bulk of the mass and energy going into the active region complex observed in the hotter coronal plasma is supplied by this process, dynamically forcing the looped structure from beneath.

Broken Detailed Balance of Filament Dynamics in Active Networks

NASA Astrophysics Data System (ADS)

Gladrow, J.; Fakhri, N.; MacKintosh, F. C.; Schmidt, C. F.; Broedersz, C. P.

2016-06-01

Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel tools to noninvasively track equilibrium and nonequilibrium fluctuations in such biopolymer networks. Here, we analytically calculate shape fluctuations of semiflexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity. Transverse bending fluctuations of the probe filaments can be decomposed into dynamic normal modes. We find that these modes no longer evolve independently under nonequilibrium driving. This effective mode coupling results in nonzero circulatory currents in a conformational phase space, reflecting a violation of detailed balance. We present predictions for the characteristic frequencies associated with these currents and investigate how the temporal signatures of motor activity determine mode correlations, which we find to be consistent with recent experiments on microtubules embedded in cytoskeletal networks.

Evaluating core technology capacity based on an improved catastrophe progression method: the case of automotive industry

NASA Astrophysics Data System (ADS)

Zhao, Shijia; Liu, Zongwei; Wang, Yue; Zhao, Fuquan

2017-01-01

Subjectivity usually causes large fluctuations in evaluation results. Many scholars attempt to establish new mathematical methods to make evaluation results consistent with actual objective situations. An improved catastrophe progression method (ICPM) is constructed to overcome the defects of the original method. The improved method combines the merits of the principal component analysis' information coherence and the catastrophe progression method's none index weight and has the advantage of highly objective comprehensive evaluation. Through the systematic analysis of the influencing factors of the automotive industry's core technology capacity, the comprehensive evaluation model is established according to the different roles that different indices play in evaluating the overall goal with a hierarchical structure. Moreover, ICPM is developed for evaluating the automotive industry's core technology capacity for the typical seven countries in the world, which demonstrates the effectiveness of the method.

Changes in the northern Adriatic molluscan community from the Holocene transgression up to the present

NASA Astrophysics Data System (ADS)

Gallmetzer, Ivo; Haselmair, Alexandra; Tomasovych, Adam; Stachowitsch, Michael; Zuschin, Martin

2016-04-01

The northern Adriatic Sea is one of the few modern, epicontinental seas comparable to typical Palaeozoic shelf environments. It has a shallow average water depth (<50 m) and was formed at the end of the last glaciation when the sea level rose. Since historical times this part of the Adriatic has been strongly influenced by human activities through multiple direct or indirect impacts (e.g. fishing, coastal building development, pollution, eutrophication, increased sedimentation), making it one of the most degraded marine ecosystems worldwide. Our study was designed to reconstruct major environmental changes here since the onset of the Holocene transgression using down-core changes in death assemblages of molluscs as indicators for ecological shifts. The sediment cores were taken at three different stations (Brijuni Islands, Croatia, off Piran, Slovenia, and off Venice, Italy), each representative of specific sediment and nutrient conditions and degrees of habitat exploitation. The cores were 1.5 m long and had diameters of 90 or 160 mm. For the molluscan shell analyses, sediment subsamples were examined for species composition, abundance, taxonomic similarity and ecological interactions (e.g. frequencies of drilling predation). In total, 98,700 valves and shells were investigated and 113 bivalve and 178 gastropod species recorded. Sedimentation rates derived from 210Pb dating are very low, between 0.15 cm/yr at Brijuni and 0.25 cm/yr at Piran. The dating of Lucinella divaricata, Timoclea ovata and Gouldia minima shells with 14C calibrated amino-acid racemisation (AAR) revealed that the cores at all three stations cover at least 6000 to 8000 years, i.e. the whole Holocene transgression period. Time averaging is high, especially in the lower core layers of Piran station, probably due to strong bioturbation. Surface mixed-layer assemblages tend to show right-skewed postmortem age-frequency distributions, whereas subsurface assemblages show unimodal or uniform shapes. Molluscan assemblages show significant interregional differences that correlate with sedimentation rate, grain size, and the occurrence of organic pollutants and heavy metals. Down-core changes in molluscan communities are also conspicuous in all cores. They partly reflect long-term changes in water depth, vegetation cover or grain size distribution caused by natural fluctuations of environmental conditions over the past millennia. In the uppermost core layers, however, these changes can be interpreted as indicators of anthropogenic impacts.

The nature and energetics of AGN-driven perturbations in the hot gas in the Perseus Cluster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhuravleva, I.; Churazov, E.; Arevalo, P.

In this paper, cores of relaxed galaxy clusters are often disturbed by AGN. Their Chandra observations revealed a wealth of structures induced by shocks, subsonic gas motions, bubbles of relativistic plasma, etc. In this paper, we determine the nature and energy content of gas fluctuations in the Perseus core by probing statistical properties of emissivity fluctuations imprinted in the soft- and hard-band X-ray images. About 80 per cent of the total variance of perturbations on ~8–70 kpc scales in the core have an isobaric nature, i.e. are consistent with subsonic displacements of the gas in pressure equilibrium with the ambientmore » medium. The observed variance translates to the ratio of energy in perturbations to thermal energy of ~13 per cent. In the region dominated by weak ‘ripples’, about half of the total variance is associated with isobaric perturbations on scales of a few tens of kpc. If these isobaric perturbations are induced by buoyantly rising bubbles, then these results suggest that most of the AGN-injected energy should first go into bubbles rather than into shocks. Using simulations of a shock propagating through the Perseus atmosphere, we found that models reproducing the observed features of a central shock have more than 50 per cent of the AGN-injected energy associated with the bubble enthalpy and only about 20 per cent is carried away with the shock. Such energy partition is consistent with the AGN-feedback model, mediated by bubbles of relativistic plasma, and supports the importance of turbulence in the cooling–heating balance.« less

Multi-decadal to centennial scale variations in sea surface temperature off southeast Korea over the last 2000 yr

NASA Astrophysics Data System (ADS)

Lee, K. E.; Park, W.; Bae, S. W.; Nam, S. I.

2016-12-01

We have reconstructed variations in sea surface temperature (SST) for the last 2000 yr by using the alkenone unsaturation index of marine sediments of cores TY2010 PC4 and ARA/ES 03-01 GC01 recovered from the southwestern part of the East Sea. The core site is chracterized by very high sedimentation rate so that a new high-resolution continuous SST record can be reconstructed with an average temporal resolution of 2-7 years. The core top alkenone temperature (20.5°C) is higher than the annual averaged in situ SST (18 °C) and it corresponds to those of summer to autumn. During the last 2000 yr, the alkenone temperatures exhibited fluctuations on multi-decadal to centennial time scales. The temperatures were relatively warm fluctuating between 19.6°C and 21°C on centennial time scale during the period of AD 0- 1200. There were two evident cold periods: AD 1200-1400 and AD 1600-1800. The lowest temperature (approximately 18°C) occurred at AD 1290 and AD 1650. The temperatures increased toward 20 centry, which is consistent with anthropogenic global warming. Results of singular spectrum analysis of the last 2000 yr SST record suggest that there is characteristic periodicity of 100 yr and 160 yr and 50-60 yr, which can be natural variability of climate system. In addition, a comparison of the SST record with global volcanic forcing data shows that volcanic events also can be correlated to the distinct cooling events.

Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children: Three cases report.

PubMed

Jia, Feiyong; Shan, Ling; Wang, Bing; Li, Honghua; Feng, Junyan; Xu, Zhida; Saad, Khaled

2018-04-08

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by complicated interactions between genetic and environmental factors. Clinical trials, including case reports, case-control studies, and a double-blinded randomized clinical study, have suggested that high-dose vitamin D3 regimens may ameliorate the core symptoms of ASD. Vitamin D3 supplementation was effective in about three-quarters of children with ASD. To further investigate the relationship between vitamin D and ASD symptoms in vitamin D-responsive autistic children, changes in symptoms were assessed in three children with ASD who were given vitamin D3 supplementation followed by a long interruption. The core symptoms of ASD were remarkably improved during the vitamin D3 supplementation period when serum 25-hydroxyvitamin D [25(OH)]D levels reached over 40.0 ng/mL. However, symptoms reappeared after the supplementation was stopped, when serum 25(OH)D levels fell below 30.0 ng/mL but were again improved with re-administration of vitamin D3 after the interruption, when serum 25(OH)D levels exceeded 40.0 ng/mL. Overall, these results showed that the core symptoms of ASD fluctuated in severity with changes in serum 25(OH)D levels in children, indicating that maintaining a responsive 25(OH)D level is important for treating ASD. Maintaining a serum 25(OH)D level between 40.0 and 100.0 ng/ml may be optimal for producing therapeutic effects in vitamin D-responsive individuals with ASD.

The nature and energetics of AGN-driven perturbations in the hot gas in the Perseus Cluster

DOE PAGES

Zhuravleva, I.; Churazov, E.; Arevalo, P.; ...

2016-03-07

In this paper, cores of relaxed galaxy clusters are often disturbed by AGN. Their Chandra observations revealed a wealth of structures induced by shocks, subsonic gas motions, bubbles of relativistic plasma, etc. In this paper, we determine the nature and energy content of gas fluctuations in the Perseus core by probing statistical properties of emissivity fluctuations imprinted in the soft- and hard-band X-ray images. About 80 per cent of the total variance of perturbations on ~8–70 kpc scales in the core have an isobaric nature, i.e. are consistent with subsonic displacements of the gas in pressure equilibrium with the ambientmore » medium. The observed variance translates to the ratio of energy in perturbations to thermal energy of ~13 per cent. In the region dominated by weak ‘ripples’, about half of the total variance is associated with isobaric perturbations on scales of a few tens of kpc. If these isobaric perturbations are induced by buoyantly rising bubbles, then these results suggest that most of the AGN-injected energy should first go into bubbles rather than into shocks. Using simulations of a shock propagating through the Perseus atmosphere, we found that models reproducing the observed features of a central shock have more than 50 per cent of the AGN-injected energy associated with the bubble enthalpy and only about 20 per cent is carried away with the shock. Such energy partition is consistent with the AGN-feedback model, mediated by bubbles of relativistic plasma, and supports the importance of turbulence in the cooling–heating balance.« less

Suppressed ion-scale turbulence in a hot high-β plasma

NASA Astrophysics Data System (ADS)

Schmitz, L.; Fulton, D. P.; Ruskov, E.; Lau, C.; Deng, B. H.; Tajima, T.; Binderbauer, M. W.; Holod, I.; Lin, Z.; Gota, H.; Tuszewski, M.; Dettrick, S. A.; Steinhauer, L. C.

2016-12-01

An economic magnetic fusion reactor favours a high ratio of plasma kinetic pressure to magnetic pressure in a well-confined, hot plasma with low thermal losses across the confining magnetic field. Field-reversed configuration (FRC) plasmas are potentially attractive as a reactor concept, achieving high plasma pressure in a simple axisymmetric geometry. Here, we show that FRC plasmas have unique, beneficial microstability properties that differ from typical regimes in toroidal confinement devices. Ion-scale fluctuations are found to be absent or strongly suppressed in the plasma core, mainly due to the large FRC ion orbits, resulting in near-classical thermal ion confinement. In the surrounding boundary layer plasma, ion- and electron-scale turbulence is observed once a critical pressure gradient is exceeded. The critical gradient increases in the presence of sheared plasma flow induced via electrostatic biasing, opening the prospect of active boundary and transport control in view of reactor requirements.

Suppressed ion-scale turbulence in a hot high-β plasma

PubMed Central

Schmitz, L.; Fulton, D. P.; Ruskov, E.; Lau, C.; Deng, B. H.; Tajima, T.; Binderbauer, M. W.; Holod, I.; Lin, Z.; Gota, H.; Tuszewski, M.; Dettrick, S. A.; Steinhauer, L. C.

2016-01-01

An economic magnetic fusion reactor favours a high ratio of plasma kinetic pressure to magnetic pressure in a well-confined, hot plasma with low thermal losses across the confining magnetic field. Field-reversed configuration (FRC) plasmas are potentially attractive as a reactor concept, achieving high plasma pressure in a simple axisymmetric geometry. Here, we show that FRC plasmas have unique, beneficial microstability properties that differ from typical regimes in toroidal confinement devices. Ion-scale fluctuations are found to be absent or strongly suppressed in the plasma core, mainly due to the large FRC ion orbits, resulting in near-classical thermal ion confinement. In the surrounding boundary layer plasma, ion- and electron-scale turbulence is observed once a critical pressure gradient is exceeded. The critical gradient increases in the presence of sheared plasma flow induced via electrostatic biasing, opening the prospect of active boundary and transport control in view of reactor requirements. PMID:28000675

Fluctuations in Wikipedia access-rate and edit-event data

NASA Astrophysics Data System (ADS)

Kämpf, Mirko; Tismer, Sebastian; Kantelhardt, Jan W.; Muchnik, Lev

2012-12-01

Internet-based social networks often reflect extreme events in nature and society by drastic increases in user activity. We study and compare the dynamics of the two major complex processes necessary for information spread via the online encyclopedia ‘Wikipedia’, i.e., article editing (information upload) and article access (information viewing) based on article edit-event time series and (hourly) user access-rate time series for all articles. Daily and weekly activity patterns occur in addition to fluctuations and bursting activity. The bursts (i.e., significant increases in activity for an extended period of time) are characterized by a power-law distribution of durations of increases and decreases. For describing the recurrence and clustering of bursts we investigate the statistics of the return intervals between them. We find stretched exponential distributions of return intervals in access-rate time series, while edit-event time series yield simple exponential distributions. To characterize the fluctuation behavior we apply detrended fluctuation analysis (DFA), finding that most article access-rate time series are characterized by strong long-term correlations with fluctuation exponents α≈0.9. The results indicate significant differences in the dynamics of information upload and access and help in understanding the complex process of collecting, processing, validating, and distributing information in self-organized social networks.

The appearance and propagation of filaments in the private flux region in Mega Amp Spherical Tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrison, J. R.; Fishpool, G. M.; Thornton, A. J.

2015-09-15

The transport of particles via intermittent filamentary structures in the private flux region (PFR) of plasmas in the MAST tokamak has been investigated using a fast framing camera recording visible light emission from the volume of the lower divertor, as well as Langmuir probes and IR thermography monitoring particle and power fluxes to plasma-facing surfaces in the divertor. The visible camera data suggest that, in the divertor volume, fluctuations in light emission above the X-point are strongest in the scrape-off layer (SOL). Conversely, in the region below the X-point, it is found that these fluctuations are strongest in the PFRmore » of the inner divertor leg. Detailed analysis of the appearance of these filaments in the camera data suggests that they are approximately circular, around 1–2 cm in diameter, but appear more elongated near the divertor target. The most probable toroidal quasi-mode number is between 2 and 3. These filaments eject plasma deeper into the private flux region, sometimes by the production of secondary filaments, moving at a speed of 0.5–1.0 km/s. Probe measurements at the inner divertor target suggest that the fluctuations in the particle flux to the inner target are strongest in the private flux region, and that the amplitude and distribution of these fluctuations are insensitive to the electron density of the core plasma, auxiliary heating and whether the plasma is single-null or double-null. It is found that the e-folding width of the time-average particle flux in the PFR decreases with increasing plasma current, but the fluctuations appear to be unaffected. At the outer divertor target, the fluctuations in particle and power fluxes are strongest in the SOL.« less

Identifying consumer-resource population dynamics using paleoecological data.

PubMed

Einarsson, Árni; Hauptfleisch, Ulf; Leavitt, Peter R; Ives, Anthony R

2016-02-01

Ecologists have long been fascinated by cyclic population fluctuations, because they suggest strong interactions between exploiter and victim species. Nonetheless, even for populations showing high-amplitude fluctuations, it is often hard to identify which species are the key drivers of the dynamics, because data are generally only available for a single species. Here, we use a paleoecological approach to investigate fluctuations in the midge population in Lake Mývatn, Iceland, which ranges over several orders of magnitude in irregular, multigeneration cycles. Previous circumstantial evidence points to consumer-resource interactions between midges and their primary food, diatoms, as the cause of these high-amplitude fluctuations. Using a pair of sediment cores from the lake, we reconstructed 26 years of dynamics of midges using egg remains and of algal groups using diagnostic pigments. We analyzed these data using statistical methods that account for both the autocorrelated nature of paleoecological data and measurement error caused by the mixing of sediment layers. The analyses revealed a signature of consumer-resource interactions in the fluctuations of midges and diatoms: diatom abundance (as inferred from biomarker pigment diatoxanthin) increased when midge abundance was low, and midge abundance (inferred from egg capsules) decreased when diatom abundance was low. Similar patterns were not found for pigments characterizing the other dominant primary producer group in the lake (cyanobacteria), subdominant algae (cryptophytes), or ubiquitous but chemically unstable biomarkers of total algal abundance (chlorophyll a); however, a significant but weaker pattern was found for the chemically stable indicator of total algal populations (β-carotene) to which diatoms are the dominant contributor. These analyses provide the first paleoecological evaluation of specific trophic interactions underlying high amplitude population fluctuations in lakes.

Correlation of Doppler noise during solar conjunctions with fluctuations in solar activity

NASA Technical Reports Server (NTRS)

Berman, A. L.; Rockwell, S. T.

1975-01-01

Deviations betweeb observed Doppler noise and the noise model during solar conjunction were analyzed. It is tentatively concluded that these deviations are due to short-term fluctuations in solar activity as seen along the signal path, and not to solar/antenna structure effects or system noise temperature.

Outer magnetospheric fluctuations and pulsar timing noise

NASA Technical Reports Server (NTRS)

Cheng, K. S.

1987-01-01

The Cheng, Ho, and Ruderman (1986) outer-magnetosphere gap model was used to investigate the stability of Crab-type outer magnetosphere gaps for pulsars having the parameter (Omega-square B) similar to that of the Crab pulsar. The Lamb, Pines, and Shaham (1978) fluctuating magnetosphere noise model was applied to the Crab pulsar to examine the type of the equation of state that best describes the structure of the neutron star. The noise model was also applied to other pulsars, and the theoretical results were compared with observational data. The results of the comparison are consistent with the stiff equation of state, as suggested by the vortex creep model of the neutron star interior. The timing-noise observations also contribute to the evidence for the existence of superfluid in the core of the neutron star.

The neural basis of trait self-esteem revealed by the amplitude of low-frequency fluctuations and resting state functional connectivity

PubMed Central

Pan, Weigang; Liu, Congcong; Yang, Qian; Gu, Yan; Yin, Shouhang

2016-01-01

Self-esteem is an affective, self-evaluation of oneself and has a significant effect on mental and behavioral health. Although research has focused on the neural substrates of self-esteem, little is known about the spontaneous brain activity that is associated with trait self-esteem (TSE) during the resting state. In this study, we used the resting-state functional magnetic resonance imaging (fMRI) signal of the amplitude of low-frequency fluctuations (ALFFs) and resting state functional connectivity (RSFC) to identify TSE-related regions and networks. We found that a higher level of TSE was associated with higher ALFFs in the left ventral medial prefrontal cortex (vmPFC) and lower ALFFs in the left cuneus/lingual gyrus and right lingual gyrus. RSFC analyses revealed that the strengths of functional connectivity between the left vmPFC and bilateral hippocampus were positively correlated with TSE; however, the connections between the left vmPFC and right inferior frontal gyrus and posterior superior temporal sulcus were negatively associated with TSE. Furthermore, the strengths of functional connectivity between the left cuneus/lingual gyrus and right dorsolateral prefrontal cortex and anterior cingulate cortex were positively related to TSE. These findings indicate that TSE is linked to core regions in the default mode network and social cognition network, which is involved in self-referential processing, autobiographical memory and social cognition. PMID:26400859

Buckling of thermally fluctuating spherical shells: Parameter renormalization and thermally activated barrier crossing

NASA Astrophysics Data System (ADS)

Baumgarten, Lorenz; Kierfeld, Jan

2018-05-01

We study the influence of thermal fluctuations on the buckling behavior of thin elastic capsules with spherical rest shape. Above a critical uniform pressure, an elastic capsule becomes mechanically unstable and spontaneously buckles into a shape with an axisymmetric dimple. Thermal fluctuations affect the buckling instability by two mechanisms. On the one hand, thermal fluctuations can renormalize the capsule's elastic properties and its pressure because of anharmonic couplings between normal displacement modes of different wavelengths. This effectively lowers its critical buckling pressure [Košmrlj and Nelson, Phys. Rev. X 7, 011002 (2017), 10.1103/PhysRevX.7.011002]. On the other hand, buckled shapes are energetically favorable already at pressures below the classical buckling pressure. At these pressures, however, buckling requires to overcome an energy barrier, which only vanishes at the critical buckling pressure. In the presence of thermal fluctuations, the capsule can spontaneously overcome an energy barrier of the order of the thermal energy by thermal activation already at pressures below the critical buckling pressure. We revisit parameter renormalization by thermal fluctuations and formulate a buckling criterion based on scale-dependent renormalized parameters to obtain a temperature-dependent critical buckling pressure. Then we quantify the pressure-dependent energy barrier for buckling below the critical buckling pressure using numerical energy minimization and analytical arguments. This allows us to obtain the temperature-dependent critical pressure for buckling by thermal activation over this energy barrier. Remarkably, both parameter renormalization and thermal activation lead to the same parameter dependence of the critical buckling pressure on temperature, capsule radius and thickness, and Young's modulus. Finally, we study the combined effect of parameter renormalization and thermal activation by using renormalized parameters for the energy barrier in thermal activation to obtain our final result for the temperature-dependent critical pressure, which is significantly below the results if only parameter renormalization or only thermal activation is considered.

Pattern and forcing of Northern Hemisphere glacier variations during the last millennium

NASA Astrophysics Data System (ADS)

Porter, Stephen C.

1986-07-01

Time series depicting mountain glacier fluctuations in the Alps display generally similar patterns over the last two centuries, as do chronologies of glacier variations for the same interval from elsewhere in the Northern Hemisphere. Episodes of glacier advance consistently are associated with intervals of high average volcanic aerosol production, as inferred from acidity variations in a Greenland ice core. Advances occur whenever acidity levels rise sharply from background values to reach concentrations ≥1.2 μequiv H +/kg above background. A phase lag of about 10-15 yr, equivalent to reported response lags of Alpine glacier termini, separates the beginning of acidity increases from the beginning of subsequent ice advances. A similar relationship, but based on limited and less-reliable historical data and on lichenometric ages, is found for the preceding 2 centuries. Calibrated radiocarbon dates related to advances of non-calving and non-surging glaciers during the earlier part of the Little Ice Age display a comparable consistent pattern. An interval of reduced acidity values between about 1090 and 1230 A.D. correlates with a time of inferred glacier contraction during the Medieval Optimum. The observed close relation between Noothern Hemisphere glacier fluctuations and variations in Greenland ice-core acidity suggests that sulfur-rich aerosols generated by volcanic eruptions are a primary forcing mechanism of glacier fluctuations, and therefore of climate, on a decadal scale. The amount of surface cooling attributable to individual large eruptions or to episodes of eruptions is simlar to the probable average temperature reduction during culminations of Little Ice Age alacier advances (ca. 0.5°-1.2°C), as inferred from depression of equilibrium-line altitudes.

Little Ice Age Fluctuations of Quelccaya Ice Cap, Peru

NASA Astrophysics Data System (ADS)

Stroup, J. S.; Kelly, M. A.; Lowell, T.

2009-12-01

A record of the past extents of Quelccaya Ice Cap (QIC) provides valuable information about tropical climate change from late glacial to recent time. Here, we examine the timing and regional significance of fluctuations of QIC during the Little Ice Age (LIA; ~1300-1850 AD). One prominent set of moraines, known as the Huancane I moraines, is located ~1 km from the present-day western ice cap margin and provides a near-continuous outline of the most recent advance of QIC. This moraine set was radiocarbon dated (~298 ± 134 and 831 ± 87 yr BP) by Mercer and Palacios (1977) and presented as some of the first evidence for cooling in the tropics during the Little Ice Age. Recent field investigations in the QIC region focused on refining the chronology of the Huancane I moraines. In 2008, new stratigraphic sections exposed by local lake-flooding events revealed multiple layers of peat within the Huancane I moraines. In both 2008 and 2009, samples were obtained for 10Be dating of boulders on Huancane I moraines. A combination of radiocarbon and 10Be ages indicate that the Huancane I moraines were deposited by ice cap expansion after ~3800 yr BP and likely by multiple advances at approximately 1000, 600, 400, and 200 yr BP. Radiocarbon and 10Be chronologies of the Huancane I moraines are compared with the Quelccaya ice core records (Thompson et al., 1985; 1986; 2006). Accumulation data from the ice core records are interpreted to indicate a significant wet period at ~1500-1700 AD followed by a significant drought at ~1720-1860 AD. We examine ice marginal fluctuations during these times to determine influence of such events on the ice cap extent.

Ultrafast Hydration Dynamics and Coupled Water-Protein Fluctuations in Apomyoglobin

NASA Astrophysics Data System (ADS)

Yang, Yi; Zhang, Luyuan; Wang, Lijuan; Zhong, Dongping

2009-06-01

Protein hydration dynamics are of fundamental importance to its structure and function. Here, we characterize the global solvation dynamics and anisotropy dynamics around the apomyoglobin surface in different conformational states (native and molten globule) by measuring the Stokes shift and anisotropy decay of tryptophan with femtosecond-resolved fluorescence upconversion. With site-directed mutagenesis, we designed sixteen mutants with one tryptophan in each, and placed the probe at a desirable position ranging from buried in the protein core to fully solvent-exposed on the protein surface. In all protein sites studied, two distinct solvation relaxations (1-8 ps and 20-200 ps) were observed, reflecting the initial collective water relaxation and subsequent hydrogen-bond network restructuring, respectively, and both are strongly correlated with protein's local structures and chemical properties. The hydration dynamics of the mutants in molten globule state are faster than those observed in native state, indicating that the protein becomes more flexible and less structured when its conformation is converted from fully-folded native state to partially-folded molten globule state. Complementary, fluorescence anisotropy dynamics of all mutants in native state show an increasing trend of wobbling times (40-260 ps) when the location of the probe is changed from a loop, to a lateral helix, and then, to the compact protein core. Such an increase in wobbling times is related to the local protein structural rigidity, which relates the interaction of water with side chains. The ultrafast hydration dynamics and related side-chain motion around the protein surface unravel the coupled water-protein fluctuations on the picosecond time scales and indicate that the local protein motions are slaved by hydrating water fluctuations.

Biasing experiments on the Advanced Toroidal Facility

NASA Astrophysics Data System (ADS)

Uckan, T.; Isler, R. C.; Jernigan, T. C.; Lyon, J. F.; Mioduszewski, P. K.; Murakami, M.; Rasmussen, D. A.; Wilgen, J. B.; Aceto, S. C.; Zielinski, J. J.

1992-09-01

Biasing experiments have been carried out in 1 T plasmas with approximately 200 kW of electron cyclotron heating (ECH) in the current-fire Advanced Toroidal Facility (ATF) torsatron. Two rail limiters, one at the top and one at the bottom of the device, located at the last closed flux surface (LCFS), are, biased at positive and negative potentials with respect to the vacuum vessel. When the limiters are positively biased at up to 300 V and the plasma density is controlled with a significantly reduced gas feed, the H(sub alpha) radiation from both the limiter and the wall drops, indicating reduced particle recycling as a result of improved particle confinement. For bias voltages around +100 V, there is almost no change of plasma stored energy W(sub p), but W(sub p) then drops with the higher biasing voltages. Positive biasing has caused the core plasma density profile to become peaked and the electric field to become more negative inside the LCFS. At the same time, edge plasma fluctuations are reduced significantly and their power spectrum becomes less broad. The propagation direction of these electrostatic fluctuations reverses to the ion diamagnetic direction, and their wavelengths become longer. The resulting fluctuation-induced particle flux is also reduced. Power deposition on the limiters is lower as a result of reduced edge plasma density and temperature. Negative biasing yields somewhat less improvement in the particle confinement while having almost no apparent effect on W(sub p) or on the core and the edge plasma density and temperature profiles. Simultaneous measurements of the plasma potential profile indicate almost no significant change. Biasing has almost no effect on the intrinsic impurity levels in the plasma.

Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations

PubMed Central

Fernandez, Fernando R.; Malerba, Paola; White, John A.

2015-01-01

The presence of voltage fluctuations arising from synaptic activity is a critical component in models of gain control, neuronal output gating, and spike rate coding. The degree to which individual neuronal input-output functions are modulated by voltage fluctuations, however, is not well established across different cortical areas. Additionally, the extent and mechanisms of input-output modulation through fluctuations have been explored largely in simplified models of spike generation, and with limited consideration for the role of non-linear and voltage-dependent membrane properties. To address these issues, we studied fluctuation-based modulation of input-output responses in medial entorhinal cortical (MEC) stellate cells of rats, which express strong sub-threshold non-linear membrane properties. Using in vitro recordings, dynamic clamp and modeling, we show that the modulation of input-output responses by random voltage fluctuations in stellate cells is significantly limited. In stellate cells, a voltage-dependent increase in membrane resistance at sub-threshold voltages mediated by Na+ conductance activation limits the ability of fluctuations to elicit spikes. Similarly, in exponential leaky integrate-and-fire models using a shallow voltage-dependence for the exponential term that matches stellate cell membrane properties, a low degree of fluctuation-based modulation of input-output responses can be attained. These results demonstrate that fluctuation-based modulation of input-output responses is not a universal feature of neurons and can be significantly limited by subthreshold voltage-gated conductances. PMID:25909971

Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations.

PubMed

Fernandez, Fernando R; Malerba, Paola; White, John A

2015-04-01

The presence of voltage fluctuations arising from synaptic activity is a critical component in models of gain control, neuronal output gating, and spike rate coding. The degree to which individual neuronal input-output functions are modulated by voltage fluctuations, however, is not well established across different cortical areas. Additionally, the extent and mechanisms of input-output modulation through fluctuations have been explored largely in simplified models of spike generation, and with limited consideration for the role of non-linear and voltage-dependent membrane properties. To address these issues, we studied fluctuation-based modulation of input-output responses in medial entorhinal cortical (MEC) stellate cells of rats, which express strong sub-threshold non-linear membrane properties. Using in vitro recordings, dynamic clamp and modeling, we show that the modulation of input-output responses by random voltage fluctuations in stellate cells is significantly limited. In stellate cells, a voltage-dependent increase in membrane resistance at sub-threshold voltages mediated by Na+ conductance activation limits the ability of fluctuations to elicit spikes. Similarly, in exponential leaky integrate-and-fire models using a shallow voltage-dependence for the exponential term that matches stellate cell membrane properties, a low degree of fluctuation-based modulation of input-output responses can be attained. These results demonstrate that fluctuation-based modulation of input-output responses is not a universal feature of neurons and can be significantly limited by subthreshold voltage-gated conductances.

The influence of spontaneous activity on stimulus processing in primary visual cortex.

PubMed

Schölvinck, M L; Friston, K J; Rees, G

2012-02-01

Spontaneous activity in the resting human brain has been studied extensively; however, how such activity affects the local processing of a sensory stimulus is relatively unknown. Here, we examined the impact of spontaneous activity in primary visual cortex on neuronal and behavioural responses to a simple visual stimulus, using functional MRI. Stimulus-evoked responses remained essentially unchanged by spontaneous fluctuations, combining with them in a largely linear fashion (i.e., with little evidence for an interaction). However, interactions between spontaneous fluctuations and stimulus-evoked responses were evident behaviourally; high levels of spontaneous activity tended to be associated with increased stimulus detection at perceptual threshold. Our results extend those found in studies of spontaneous fluctuations in motor cortex and higher order visual areas, and suggest a fundamental role for spontaneous activity in stimulus processing. Copyright © 2011. Published by Elsevier Inc.

Shape and Displacement Fluctuations in Soft Vesicles Filled by Active Particles

PubMed Central

Paoluzzi, Matteo; Di Leonardo, Roberto; Marchetti, M. Cristina; Angelani, Luca

2016-01-01

We investigate numerically the dynamics of shape and displacement fluctuations of two-dimensional flexible vesicles filled with active particles. At low concentration most of the active particles accumulate at the boundary of the vesicle where positive particle number fluctuations are amplified by trapping, leading to the formation of pinched spots of high density, curvature and pressure. At high concentration the active particles cover the vesicle boundary almost uniformly, resulting in fairly homogeneous pressure and curvature, and nearly circular vesicle shape. The change between polarized and spherical shapes is driven by the number of active particles. The center-of-mass of the vesicle performs a persistent random walk with a long time diffusivity that is strongly enhanced for elongated active particles due to orientational correlations in their direction of propulsive motion. In our model shape-shifting induces directional sensing and the cell spontaneously migrate along the polarization direction. PMID:27678166

Multiplicative and additive modulation of neuronal tuning with population activity affects encoded information

PubMed Central

Arandia-Romero, Iñigo; Tanabe, Seiji; Drugowitsch, Jan; Kohn, Adam; Moreno-Bote, Rubén

2016-01-01

Numerous studies have shown that neuronal responses are modulated by stimulus properties, and also by the state of the local network. However, little is known about how activity fluctuations of neuronal populations modulate the sensory tuning of cells and affect their encoded information. We found that fluctuations in ongoing and stimulus-evoked population activity in primate visual cortex modulate the tuning of neurons in a multiplicative and additive manner. While distributed on a continuum, neurons with stronger multiplicative effects tended to have less additive modulation, and vice versa. The information encoded by multiplicatively-modulated neurons increased with greater population activity, while that of additively-modulated neurons decreased. These effects offset each other, so that population activity had little effect on total information. Our results thus suggest that intrinsic activity fluctuations may act as a `traffic light' that determines which subset of neurons are most informative. PMID:26924437

Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.

PubMed

Iversen, Lars; Tu, Hsiung-Lin; Lin, Wan-Chen; Christensen, Sune M; Abel, Steven M; Iwig, Jeff; Wu, Hung-Jen; Gureasko, Jodi; Rhodes, Christopher; Petit, Rebecca S; Hansen, Scott D; Thill, Peter; Yu, Cheng-Han; Stamou, Dimitrios; Chakraborty, Arup K; Kuriyan, John; Groves, Jay T

2014-07-04

Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS molecules catalyzing nucleotide exchange in H-Ras. Single-molecule kinetic traces revealed that SOS samples a broad distribution of turnover rates through stochastic fluctuations between distinct, long-lived (more than 100 seconds), functional states. The expected allosteric activation of SOS by Ras-guanosine triphosphate (GTP) was conspicuously absent in the mean rate. However, fluctuations into highly active states were modulated by Ras-GTP. This reveals a mechanism in which functional output may be determined by the dynamical spectrum of rates sampled by a small number of enzymes, rather than the ensemble average. Copyright © 2014, American Association for the Advancement of Science.

Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors

PubMed Central

Woods, Kristina N.; Pfeffer, Jürgen; Dutta, Arpana; Klein-Seetharaman, Judith

2016-01-01

G protein-coupled receptors are a large family of membrane proteins activated by a variety of structurally diverse ligands making them highly adaptable signaling molecules. Despite recent advances in the structural biology of this protein family, the mechanism by which ligands induce allosteric changes in protein structure and dynamics for its signaling function remains a mystery. Here, we propose the use of terahertz spectroscopy combined with molecular dynamics simulation and protein evolutionary network modeling to address the mechanism of activation by directly probing the concerted fluctuations of retinal ligand and transmembrane helices in rhodopsin. This approach allows us to examine the role of conformational heterogeneity in the selection and stabilization of specific signaling pathways in the photo-activation of the receptor. We demonstrate that ligand-induced shifts in the conformational equilibrium prompt vibrational resonances in the protein structure that link the dynamics of conserved interactions with fluctuations of the active-state ligand. The connection of vibrational modes creates an allosteric association of coupled fluctuations that forms a coherent signaling pathway from the receptor ligand-binding pocket to the G-protein activation region. Our evolutionary analysis of rhodopsin-like GPCRs suggest that specific allosteric sites play a pivotal role in activating structural fluctuations that allosterically modulate functional signals. PMID:27849063

Hot Spots in a Network of Functional Sites

PubMed Central

Ozbek, Pemra; Soner, Seren; Haliloglu, Turkan

2013-01-01

It is of significant interest to understand how proteins interact, which holds the key phenomenon in biological functions. Using dynamic fluctuations in high frequency modes, we show that the Gaussian Network Model (GNM) predicts hot spot residues with success rates ranging between S 8–58%, C 84–95%, P 5–19% and A 81–92% on unbound structures and S 8–51%, C 97–99%, P 14–50%, A 94–97% on complex structures for sensitivity, specificity, precision and accuracy, respectively. High specificity and accuracy rates with a single property on unbound protein structures suggest that hot spots are predefined in the dynamics of unbound structures and forming the binding core of interfaces, whereas the prediction of other functional residues with similar dynamic behavior explains the lower precision values. The latter is demonstrated with the case studies; ubiquitin, hen egg-white lysozyme and M2 proton channel. The dynamic fluctuations suggest a pseudo network of residues with high frequency fluctuations, which could be plausible for the mechanism of biological interactions and allosteric regulation. PMID:24023934

LETTER: Biased limiter experiments on the Advanced Toroidal Facility (ATF) torsatron

NASA Astrophysics Data System (ADS)

Uckan, T.; Isler, R. C.; Jernigan, T. C.; Lyon, J. F.; Mioduszewski, P. K.; Murakami, M.; Rasmussen, D. A.; Wilgen, J. B.; Aceto, S. C.; Zielinski, J. J.

1994-02-01

The Advanced Toroidal Facility (ATF) torsatron incorporates two rail limiters that can be positioned by external controls. The influence on the plasma parameters of biasing these limiters both positively and negatively with respect to the walls has been investigated. Experiments have been carried out in the electron cyclotron heated plasmas at 200 kW with a typical density of 5 × 1012 cm-3 and a central electron temperature of ~900 eV. Negative biasing produces only small changes in the plasma parameters, but positive biasing increases the particle confinement by about a factor of 5, although the plasma stored energy does fall at the higher voltages. In addition, positive biasing produces the following effects compared with floating limiter discharges: the core density profiles become peaked rather than hollow, the electric field at the edge becomes more negative (pointing radially inward), the magnitudes of the edge fluctuations and the fluctuation induced transport are reduced, the fluctuation wavelengths become longer and their propagation direction reverses from the electron to the ion diamagnetic direction. Neither polarity of biasing appears to affect the impurity content or transport

Historical trends in salinity and substrate in central Florida Bay: A paleoecological reconstruction using modern analogue data

USGS Publications Warehouse

Brewster-Wingard, G. L.; Ishman, S.E.

1999-01-01

Understanding the natural spatial and temporal variability that exists within an ecosystem is a critical component of efforts to restore systems to their natural state. Analysis of benthic foraminifers and molluscs from modern monitoring sites within Florida Bay allows us to determine what environmental parameters control spatial and temporal variability of their assemblages. Faunal assemblages associated with specific environmental parameters, including salinity and substrate, serve as proxies for an interpretation of paleoecologic data. The faunal record preserved in two shallow (< 2 m) cores in central Florida Bay (Russell Bank and Bob Allen Bank) provides a record of historical trends in environmental parameters for those sites. Analysis of these two cores has revealed two distinct patterns of salinity change at these sites: 1) a long-term trend of slightly increasing average salinity; and 2) a relatively rapid change to salinity fluctuations of greater frequency and amplitude, beginning around the turn of the century and becoming most pronounced after 1940. The degree of variability in substrate types at each locality limits interpretations of substrate trends to specific sites. A common sequence of change is present in the Russell Bank and Bob Allen Bank cores: from mixed grass and bare-sediment indicators at the bottom of the cores, to bare-sediment dwellers in the center, to a dominance of vegetative-cover indicators at the top of the cores. Changes in interpreted salinity patterns around the turn of the century are consistent with the timing of the construction of the Flagler Railroad from 1905 to 1912, and the Tamiami Trail and the canal and levee systems between 1915 and 1928. Beginning around 1940, the changes in the frequency and amplitude of salinity fluctuations may be related to changes in water management practices, meteorologic events (frequent hurricanes coupled with severe droughts in 1943 and 1944), or a combination of factors. The correspondence of these changes in Florida Bay with changes in the terrestrial Everglades suggests factors affecting the entire ecosystem are responsible for the salinity and substrate patterns seen in Florida Bay.

Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells.

PubMed

Redhai, Siamak; Hellberg, Josephine E E U; Wainwright, Mark; Perera, Sumeth W; Castellanos, Felix; Kroeger, Benjamin; Gandy, Carina; Leiblich, Aaron; Corrigan, Laura; Hilton, Thomas; Patel, Benjamin; Fan, Shih-Jung; Hamdy, Freddie; Goberdhan, Deborah C I; Wilson, Clive

2016-10-01

Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis is then accelerated to replenish the DCG pool remains poorly characterised. Here we demonstrate that each prostate-like secondary cell (SC) in the paired adult Drosophila melanogaster male accessory glands contains approximately ten large DCGs, which are loaded with the Bone Morphogenetic Protein (BMP) ligand Decapentaplegic (Dpp). These DCGs can be marked in living tissue by a glycophosphatidylinositol (GPI) lipid-anchored form of GFP. In virgin males, BMP signalling is sporadically activated by constitutive DCG secretion. Upon mating, approximately four DCGs are typically released immediately, increasing BMP signalling, primarily via an autocrine mechanism. Using inducible knockdown specifically in adult SCs, we show that secretion requires the Soluble NSF Attachment Protein, SNAP24. Furthermore, mating-dependent BMP signalling not only promotes cell growth, but is also necessary to accelerate biogenesis of new DCGs, restoring DCG number within 24 h. Our analysis therefore reveals an autocrine BMP-mediated feedback mechanism for matching DCG release to replenishment as secretion rates fluctuate, and might explain why in other disease-relevant systems, like pancreatic β-cells, BMP signalling is also implicated in the control of secretion.

Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells

PubMed Central

Redhai, Siamak; Hellberg, Josephine E. E. U.; Wainwright, Mark; Perera, Sumeth W.; Castellanos, Felix; Kroeger, Benjamin; Gandy, Carina; Leiblich, Aaron; Corrigan, Laura; Hilton, Thomas; Patel, Benjamin; Fan, Shih-Jung; Hamdy, Freddie; Goberdhan, Deborah C. I.

2016-01-01

Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis is then accelerated to replenish the DCG pool remains poorly characterised. Here we demonstrate that each prostate-like secondary cell (SC) in the paired adult Drosophila melanogaster male accessory glands contains approximately ten large DCGs, which are loaded with the Bone Morphogenetic Protein (BMP) ligand Decapentaplegic (Dpp). These DCGs can be marked in living tissue by a glycophosphatidylinositol (GPI) lipid-anchored form of GFP. In virgin males, BMP signalling is sporadically activated by constitutive DCG secretion. Upon mating, approximately four DCGs are typically released immediately, increasing BMP signalling, primarily via an autocrine mechanism. Using inducible knockdown specifically in adult SCs, we show that secretion requires the Soluble NSF Attachment Protein, SNAP24. Furthermore, mating-dependent BMP signalling not only promotes cell growth, but is also necessary to accelerate biogenesis of new DCGs, restoring DCG number within 24 h. Our analysis therefore reveals an autocrine BMP-mediated feedback mechanism for matching DCG release to replenishment as secretion rates fluctuate, and might explain why in other disease-relevant systems, like pancreatic β-cells, BMP signalling is also implicated in the control of secretion. PMID:27727275

Offshore Evidence for an Undocumented Tsunami Event in the ‘Low Risk’ Gulf of Aqaba-Eilat, Northern Red Sea

PubMed Central

Goodman Tchernov, Beverly; Katz, Timor; Shaked, Yonathan; Qupty, Nairooz; Kanari, Mor; Niemi, Tina; Agnon, Amotz

2016-01-01

Although the Gulf of Aqaba-Eilat is located in the tectonically active northern Red Sea, it has been described as low-risk with regard to tsunami activity because there are no modern records of damaging tsunami events and only one tsunami (1068 AD) referred to in historical records. However, this assessment may be poorly informed given that the area was formed by and is located along the seismically active Dead Sea Fault, its population is known to fluctuate in size and literacy in part due to its harsh hyper-arid climate, and there is a dearth of field studies addressing the presence or absence of tsunamigenic deposits. Here we show evidence from two offshore cores for a major paleotsunami that occurred ~2300 years ago with a sedimentological footprint that far exceeds the scarce markers of the historically mentioned 1068 AD event. The interpretation is based on the presence of a laterally continuous and synchronous, anomalous sedimentological deposit that includes allochtonous inclusions and unique structural characteristics. Based on sedimentological parameters, these deposits could not be accounted for by other transport events, or other known background sedimentological processes. PMID:26815553

Offshore Evidence for an Undocumented Tsunami Event in the 'Low Risk' Gulf of Aqaba-Eilat, Northern Red Sea.

PubMed

Goodman Tchernov, Beverly; Katz, Timor; Shaked, Yonathan; Qupty, Nairooz; Kanari, Mor; Niemi, Tina; Agnon, Amotz

2016-01-01

Although the Gulf of Aqaba-Eilat is located in the tectonically active northern Red Sea, it has been described as low-risk with regard to tsunami activity because there are no modern records of damaging tsunami events and only one tsunami (1068 AD) referred to in historical records. However, this assessment may be poorly informed given that the area was formed by and is located along the seismically active Dead Sea Fault, its population is known to fluctuate in size and literacy in part due to its harsh hyper-arid climate, and there is a dearth of field studies addressing the presence or absence of tsunamigenic deposits. Here we show evidence from two offshore cores for a major paleotsunami that occurred ~2300 years ago with a sedimentological footprint that far exceeds the scarce markers of the historically mentioned 1068 AD event. The interpretation is based on the presence of a laterally continuous and synchronous, anomalous sedimentological deposit that includes allochtonous inclusions and unique structural characteristics. Based on sedimentological parameters, these deposits could not be accounted for by other transport events, or other known background sedimentological processes.

Preliminary paleontologic report on cores 19A and 19B, from Russell Bank, Everglades National Park, Florida Bay

USGS Publications Warehouse

Brewster-Wingard, G. L.; Ishman, S.E.; Willard, D.A.; Edwards, L.E.; Holmes, C.W.

1997-01-01

The fauna and flora preserved in two cores, 19A and 19B, from the south side of Russell Bank (N 25 03.831', W 80 37.486') in north-central Florida Bay, Everglades National Park, Florida, record a history of environmental change over the last century. The benthic foraminifera and molluscs indicate fluctuating salinities with increasing average salinity upcore in core 19B. Shifts from low salinity (12-15 ppt) to higher average salinity (30 ppt) occurred at 70-66 cm and 24-18 cm in core 19B (approximately 1937-1940 and 1975-1980). The inverse, shifts from periods of higher average salinity to periods of lower salinity, occurred at 140 cm, 90 cm, and 42 cm (approximately 1880, 1921, and 1960). Significant changes in the molluscan fauna indicative of specific substrate types occur at 88 cm, 68 cm, and 22 cm. The lower portion of the core is dominated by a mixture of sediment and grass dwellers, the middle portion by sediment dwellers, and the upper portion of the core by grass and finally grass and algae dwellers. Changes occur in the floral assemblages in core 19A, but the significance of these changes is unclear. Three subtle shifts occur in the pollen assemblages indicating the onshore vegetation was responding to some environmental factor. Two peaks in dinocyst abundance occur in core 19A, but the composition of dinocyst assemblages remains relatively stable throughout the core. Correspondence between changes in salinity and onshore vegetation changes is consistent with results from previous cores. The pattern of increased salinity upcore is consistent with patterns seen in core T24 from the mouth of Taylor Creek and in core 6A from Bob Allen mudbank.

12 CFR 1265.3 - Core mission activities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Core mission activities. 1265.3 Section 1265.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS CORE MISSION ACTIVITIES § 1265.3 Core mission activities. The following Bank activities qualify as core mission activities: (a...

12 CFR 940.3 - Core mission activities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Core mission activities. 940.3 Section 940.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MISSION CORE MISSION ACTIVITIES § 940.3 Core mission activities. The following Bank activities qualify as core mission activities: (a...

A Brunhes-Matuyama polarity transition record from anoxic sediments in the South Atlantic (Ocean Drilling Program Hole 1082C)

NASA Astrophysics Data System (ADS)

Yamazaki, T.; Oda, H.

2001-08-01

A paleomagnetic study was performed on Hole 1082C sediment cores taken during the Ocean Drilling Program (ODP) Leg 175 in the South Atlantic in order to obtain a high-resolution Brunhes-Matuyama (B/M) polarity transition record. An average sedimentation rate was as high as 10 cm/kyr. The cores consist of strongly anoxic sediments, which is common for the areas of large material supply. Anoxic sediments, which are geochemically quite active, were considered to be unsuitable for studies on detailed behavior of the geomagnetic field such as polarity transitions. For global site distribution, however, it is necessary to make efforts to retrieve paleomagnetic records from such sediments. A continuous record of directional changes around the transition was obtained from U-channel samples after cleaning by stepwise alternating-field (AF) demagnetization. Consistency of the record was checked using discrete samples taken from the other half of the cores. The coring-induced magnetic overprint of radial-inward direction, which has often been reported from ODP piston-cores, was negligibly small in our cores. Relative paleointensity variation was estimated from remanent intensities of the discrete samples normalized by artificial remanences. Our record shows following features of the B/M transition similar to those already reported by previous studies. A zone of large directional fluctuations with low paleointensities occurs just before the main transition (788 to 795 ka based on the oxygen-isotope stratigraphy), which would correspond to the "precursor" of Hartl and Tauxe (1996). The virtual geomagnetic poles (VGPs) at the precursor lie along the so-called preferred longitudinal bands over the north-south Americas and Australia-east Asia. After the main transition from the reversed to normal polarity, VGPs stayed in the middle-to-high latitudes over the North America with an intermediate paleointensity for about 5~kyrs, and then moved in the vicinity of the North Pole with full recovery of intensity. Such behavior was reported by Oda et al. (2000). These similarities suggest that the anoxic sediments at Site 1082 could record the behavior of the geomagnetic field rather faithfully, although the remanence may be of chemical origin.

Effective tension and fluctuations in active membranes.

PubMed

Loubet, Bastien; Seifert, Udo; Lomholt, Michael Andersen

2012-03-01

We calculate the fluctuation spectrum of the shape of a lipid vesicle or cell exposed to a nonthermal source of noise. In particular, we take constraints on the membrane area and the volume of fluid that it encapsulates into account when obtaining expressions for the dependency of the membrane tension on the noise. We then investigate three possible origins of the nonthermal noise taken from the literature: A direct force, which models an external medium pushing on the membrane, a curvature force, which models a fluctuating spontaneous curvature, and a permeation force coming from an active transport of fluid through the membrane. For the direct force and curvature force cases, we compare our results to existing experiments on active membranes.

The Holocene Record of the Arctic Oscillation and a Possible Link to Solar Variability

NASA Astrophysics Data System (ADS)

Rand, J.; Darby, D. A.; Ortiz, J.; Cook, M. Y.; Keigwin, L.

2007-12-01

Detailed Fe grain provenance for a 19.9 meter long piston core (HLY02-JPC16) with about 17.5 m of Holocene sediment provides a sub-century scale resolution of the Arctic Oscillation (AO). The presence of Fe grains matched to Russian shelves fluctuates throughout this core, located 125 km north of Alaska in 1300 m water depth. High amounts of these Fe grains indicate a strong positive AO. While century scale fluctuations occur in the influx of Russian ice-rafted grains at this core site, a significant periodicity of about 1500 years exists that is similar to that of Be-10 in the Greenland ice cores. This begs the question as to how the AO might be linked to solar variations, especially such weak ones. The sources of sea ice rafting throughout the Holocene are compared to Modern sea ice samples and there is generally a good match. There is much greater heterogeneity in sources based on Fe grain provenance than other techniques for sourcing sea ice today. While the Laptev Sea is certainly an important sea ice entrainment area, it is by no means the only one and not even the most important over the long term. This distinction lies with northern Canadian sources, especially the Queen Elizabeth Islands facing the Arctic Ocean. The AO plays a major role in mixing sea ice from Russian and North American sources, especially during ++AO events. At these times, not only does the Trans Polar Drift swing closer to North America introducing sea ice from the Russian shelves such as the Laptev Sea to the Beaufort Gyre (BG), but it also aids in dragging some of the BG ice toward Fram Strait. This BG ice is a mix of North American and Russian ice and thus it is not surprising to find sediment from both sources in ice along the drift path of this ice moving toward Fram Strait.

Developing Resource-Informed Strategic Assessments and Recommendations

DTIC Science & Technology

2008-01-01

one uses a 3 percent or a 7 percent real discount rate ( the set of values suggested by the Office of Management and Budget) and on whether one ...important—protection against the risks posed by normal financial- market fluctuations. Managing risk has been a traditional core element of portfolio ...strategy—reduce the burden on the U.S. military by building local capacity—but it is conducted at a much

Direct Numerical Simulation of the Influence of Plasmas on Turbulent Flows

DTIC Science & Technology

2006-12-31

studying the ability of plasmas to directly influence the turbulent fluctuations in the interior of flows. Laser energy deposition has been considered...background turbulence . Signifi- cant expansion is observed in the turbulent core. "* The blast wave is initially very strong and is not distorted by the...enough to get distorted through interaction with the turbulence . "* Statistics computed for turbulent kinetic energy and divergence of velocity

Formation and evolution of quasi-interchange convection cell on the HL-2A tokamak

NASA Astrophysics Data System (ADS)

Shi, P. W.; Chen, W.; Shi, Z. B.; Duan, X. R.; Zhong, W. L.; Jiang, M.; Yang, Z. C.; Yu, L. M.; Wen, J.; Liang, A. S.; Yu, D. L.; Liu, Y.; Yang, Q. W.

2018-06-01

Formation and evolution of quasi-interchange convection cell have been observed for the first time by an electron cyclotron emission imaging (ECEI) system on the HL-2A tokamak. The instability with mode numbers of m/n = -1/-1 and a frequency of 2-4 kHz propagates in the electron diamagnetic drift direction. The mode downgrades the inner stored energy WE and enhances the divertor Hα signal, which indicates a degradation of plasma confinement. The ECEI reveals that the colder core temperature fluctuation distorts to a crescent shape, while a bubble originates from hot fluctuation gradually and draws into the concave side of the crescent. A finger-like structure can be observed during the convection process, and it presents a typical feature of the quasi-interchange model. The radial structure of the interchange mode obtained from electron cyclotron emission is quite narrow at the high field side but relatively wider at the low field side. Further analysis suggests that the discharge parameters are favorable for the excitation of interchange mode, and the stability criterion is violated in the core region. Moreover, the experimental frequency agrees with that given by the linear dispersion relation of interchange instability. The large grow rate suggests that the mode grows on a very short time scale.

Geomagnetic field and length-of-day fluctuations at decadal and subdecadal time scales. A plea for looking beyond the atmosphere for partners in Earth's rotation

NASA Astrophysics Data System (ADS)

Demetrescu, C.; Dobrica, V.; Stefan, C.

2017-12-01

A rich scientific literature is linking length-of-day (LOD) fluctuations to geomagnetic field and flow oscillations in the fluid outer core. We demostrate that the temporal evolution of the geomagnetic field shows the existence of several oscillations at decadal, inter-decadal, and sub-centennial time scales that superimpose on a so-called inter-centennial constituent. We show that while the subcentennial oscillations of the geomagnetic field, produced by torsional oscillations in the core, could be linked to oscillations of LOD at a similar time scale, the oscillations at decadal and sub-decadal time scales, of external origin, can be found in LOD too. We discuss these issues from the perspective of long time-span main field models (gufm1 - Jackson et al., 2000; COV-OBS - Gillet et al., 2013) that are used to retrieve time series of geomagnetic elements in a 2.5x2.5° network. The decadal and sub-decadal constituents of the time series of annual values in LOD and geomagnetic field were separated in the cyclic component of a Hodrick-Prescott filtering applied to data, and shown to highly correlate to variations of external sources such as the magnetospheric ring current.

Intensity-modulated refractive index sensor with anti-light source fluctuation based on no-core fiber filter

NASA Astrophysics Data System (ADS)

Zhang, Cheng; Xu, Shan; Zhao, Junfa; Li, Hongqiang; Bai, Hua; Miao, Changyun

2017-12-01

A differential intensity-modulated refractive index (RI) sensor consisting of a no-core fiber (NCF) filter, a circulator and two fiber Bragg gratings (FBGs) is proposed and demonstrated. A section of the NCF is sandwiched between two parts of single mode fibers (SMFs) to form a band-pass filter. The Bragg wavelengths of the FBGs are chosen at the two edges of the filter, respectively. The peak wavelength of the NCF filter has a red-shift with the increase of the surrounding refractive index (SRI) while the Bragg wavelengths have no change, which results in the variation of the difference of the two FBGs reflective intensities, thus the differential intensity modulation to the SRI can be accomplished. Compared with directly connecting the NCF filter and the FBGs, this sensing structure can increase the output power so as to improve the measuring resolution. The experimental results show that the RI sensitivities are -99.191 dB/RIU and -139.958 dB/RIU at the range of 1.3329-1.3781 and 1.3781-1.401, respectively. In addition, the disturbance from the light source fluctuation and temperature cross sensitivity can be minimized effectively, which has great potential in actual applications.

Early and late Holocene glacial fluctuations and tephrostratigraphy, Cabin Lake, Alaska

USGS Publications Warehouse

Zander, Paul D.; Kaufman, Darrell S.; Kuehn, Stephen C.; Wallace, Kristi L.; Anderson, R. Scott

2013-01-01

Marked changes in sediment types deposited in Cabin Lake, near Cordova, Alaska, represent environmental shifts during the early and late Holocene, including fluctuations in the terminal position of Sheridan Glacier. Cabin Lake is situated to receive meltwater during periods when the outwash plain of the advancing Sheridan Glacier had aggraded. A brief early Holocene advance from 11.2 to 11.0 cal ka is represented by glacial rock flour near the base of the sediment core. Non-glacial lake conditions were restored for about 1000 years before the water level in Cabin Lake lowered and the core site became a fen. The fen indicates drier-than-present conditions leading up to the Holocene thermal maximum. An unconformity spanning 5400 years during the mid-Holocene is overlain by peat until 1110 CE when meltwater from Sheridan Glacier returned to the basin. Three intervals of an advanced Sheridan Glacier are recorded in the Cabin Lake sediments during the late Holocene: 1110–1180, 1260–1540 and 1610–1780 CE. The sedimentary sequence also contains the first five reported tephra deposits from the Copper River delta region, and their geochemical signatures suggest that the sources are the Cook Inlet volcanoes Redoubt, Augustine and Crater Peak, and possibly Mt Churchill in the Wrangell Volcanic field.

Late Cretaceous (Late Campanian-Maastrichtian) sea surface temperature record of the Boreal Chalk Sea

NASA Astrophysics Data System (ADS)

Thibault, N.; Harlou, R.; Schovsbo, N. H.; Stemmerik, L.; Surlyk, F.

2015-11-01

The last 8 Myr of the Cretaceous greenhouse interval were characterized by a progressive global cooling with superimposed cool/warm fluctuations. The mechanisms responsible for these climatic fluctuations remain a source of debate that can only be resolved through multi-disciplinary studies and better time constraints. For the first time, we present a record of very high-resolution (ca. 4.5 kyr) sea-surface temperature (SST) changes from the Boreal epicontinental Chalk Sea (Stevns-1 core, Denmark), tied to an astronomical time scale of the late Campanian-Maastrichtian (74 to 66 Myr). Well-preserved bulk stable isotope trends and calcareous nannofossil palaeoecological patterns from the fully cored Stevns-1 borehole show marked changes in SSTs. These variations correlate with deep-water records of climate change from the tropical South Atlantic and Pacific oceans but differ greatly from the climate variations of the North Atlantic. We demonstrate that the onset and end of the early Maastrichtian cooling and of the large negative Campanian-Maastrichtian boundary carbon isotope excursion are coincident in the Chalk Sea. The direct link between SSTs and δ13C variations in the Chalk Sea reassesses long-term glacio-eustasy as the potential driver of carbon isotope and climatic variations in the Maastrichtian.

Late Cretaceous (late Campanian-Maastrichtian) sea-surface temperature record of the Boreal Chalk Sea

NASA Astrophysics Data System (ADS)

Thibault, Nicolas; Harlou, Rikke; Schovsbo, Niels H.; Stemmerik, Lars; Surlyk, Finn

2016-02-01

The last 8 Myr of the Cretaceous greenhouse interval were characterized by a progressive global cooling with superimposed cool/warm fluctuations. The mechanisms responsible for these climatic fluctuations remain a source of debate that can only be resolved through multi-disciplinary studies and better time constraints. For the first time, we present a record of very high-resolution (ca. 4.5 kyr) sea-surface temperature (SST) changes from the Boreal epicontinental Chalk Sea (Stevns-1 core, Denmark), tied to an astronomical timescale of the late Campanian-Maastrichtian (74 to 66 Ma). Well-preserved bulk stable isotope trends and calcareous nannofossil palaeoecological patterns from the fully cored Stevns-1 borehole show marked changes in SSTs. These variations correlate with deep-water records of climate change from the tropical South Atlantic and Pacific oceans but differ greatly from the climate variations of the North Atlantic. We demonstrate that the onset and end of the early Maastrichtian cooling and of the large negative Campanian-Maastrichtian boundary carbon isotope excursion are coincident in the Chalk Sea. The direct link between SSTs and δ13C variations in the Chalk Sea reassesses long-term glacio-eustasy as the potential driver of carbon isotope and climatic variations in the Maastrichtian.

Oxygenation variability off Northern Chile during the last two centuries

NASA Astrophysics Data System (ADS)

Díaz-Ochoa, J. A.; Pantoja, S.; de Lange, G. J.; Lange, C. B.; Sánchez, G. E.; Acuña, V. R.; Muñoz, P.; Vargas, G.

2010-07-01

The Peru Chile Current ecosystem is characterized by high biological productivity and important fisheries. Although this system is likely to be severely affected by climate change, its response to current global warming is still uncertain. In this paper we analyze 10-166 year old sediments in two cores collected in Mejillones Bay, an anoxic sedimentary setting favorable for preservation of proxies. Based on a 166 year chronology we used indicators of bottom water oxygenation proxies (Mo, V, S, and the (lycopane+n-C35)/n-C31) ratio) and surface water productivity (biogenic opal, counts of diatom valves, biogenic Ba, organic carbon and chlorins) to reconstruct environmental variations in Mejillones Bay. We find that at decadal scales, and during the last two centuries, a shift in the coastal marine ecosystem off Northern Chile took place which was characterized by intense ENSO-like activity and large fluctuations in biological export productivity, in bottom water oxygenation, and increased eolic activity (inferred from Ti/Al and Zr/Al). On top of this short-term variability, a gradual increase of sulfidic conditions has occurred being even more intensified since the early 1960s.

Oxygenation variability in Mejillones Bay, off northern Chile, during the last two centuries

NASA Astrophysics Data System (ADS)

Díaz-Ochoa, J. A.; Pantoja, S.; de Lange, G. J.; Lange, C. B.; Sánchez, G. E.; Acuña, V. R.; Muñoz, P.; Vargas, G.

2011-01-01

The Peru Chile Current ecosystem is characterized by high biological productivity and important fisheries. Although this system is likely to be severely affected by climate change, its response to current global warming is still uncertain. In this paper, we analyze 10-166 year-old sediments in two cores collected from Mejillones Bay, an anoxic sedimentary setting favorable for the preservation of proxies. Based on a 166-year chronology, we used proxies of bottom-water oxygenation (Mo, V, S, and the (lycopane + n-C35)/n-C31 ratio) and surface water productivity (biogenic opal, counts of diatom valves, biogenic Ba, organic carbon, and chlorins) to reconstruct environmental variations in Mejillones Bay. During the last two centuries, a shift took place in the coastal marine ecosystem of Bahia Mejillones at decadal scales. This shift was characterized by intense ENSO-like activity, large-scale fluctuations in biological export productivity and bottom water oxygenation, and increased eolian activity (inferred from Ti/Al and Zr/Al). This short-term variability was accompanied by a gradual increase of sulfidic conditions that has intensified since the early 1960s.

Structural instability and phase co-existence driven non-Gaussian resistance fluctuations in metal nanowires at low temperatures.

PubMed

Bid, Aveek; Raychaudhuri, A K

2016-11-11

We report a detailed experimental study of the resistance fluctuations measured at low temperatures in high quality metal nanowires ranging in diameter from 15-200 nm. The wires exhibit co-existing face-centered-cubic and 4H hcp phases of varying degrees as determined from the x-ray diffraction data. We observe the appearance of a large non-Gaussian noise for nanowires of diameter smaller than 50 nm over a certain temperature range around ≈30 K. The diameter range ∼30 nm, where the noise has maxima coincides with the maximum volume fraction of the co-existing 4H hcp phase thus establishing a strong link between the fluctuation and the phase co-existence. The resistance fluctuation in the same temperature range also shows a deviation of [Formula: see text] behavior at low frequency with appearance of single frequency Lorentzian type contribution in the spectral power density. The fluctuations are thermally activated with an activation energy [Formula: see text] meV, which is of same order as the activation energy of creation of stacking fault in FCC metals that leads to the co-existing crystallographic phases. Combining the results of crystallographic studies of the nanowires and analysis of the resistance fluctuations we could establish the correlation between the appearance of the large resistance noise and the onset of phase co-existence in these nanowires.

Cerebellar Purkinje Cells Generate Highly Correlated Spontaneous Slow-Rate Fluctuations.

PubMed

Cao, Ying; Liu, Yu; Jaeger, Dieter; Heck, Detlef H

2017-01-01

Cerebellar Purkinje cells (PC) fire action potentials at high, sustained rates. Changes in spike rate that last a few tens of milliseconds encode sensory and behavioral events. Here we investigated spontaneous fluctuations of PC simple spike rate at a slow time scale of the order of 1 s. Simultaneous recordings from pairs of PCs that were aligned either along the sagittal or transversal axis of the cerebellar cortex revealed that simple spike rate fluctuations at the 1 s time scale were highly correlated. Each pair of PCs had either a predominantly positive or negative slow-rate correlation, with negative correlations observed only in PC pairs aligned along the transversal axis. Slow-rate correlations were independent of faster rate changes that were correlated with fluid licking behavior. Simultaneous recordings from PCs and cerebellar nuclear (CN) neurons showed that slow-rate fluctuations in PC and CN activity were also highly correlated, but their correlations continually alternated between periods of positive and negative correlation. The functional significance of this new aspect of cerebellar spike activity remains to be determined. Correlated slow-rate fluctuations seem too slow to be involved in the real-time control of ongoing behavior. However, slow-rate fluctuations of PCs converging on the same CN neuron are likely to modulate the excitability of the CN neuron, thus introduce a possible slow modulation of cerebellar output activity.

What kind of noise is brain noise: anomalous scaling behavior of the resting brain activity fluctuations

PubMed Central

Fraiman, Daniel; Chialvo, Dante R.

2012-01-01

The study of spontaneous fluctuations of brain activity, often referred as brain noise, is getting increasing attention in functional magnetic resonance imaging (fMRI) studies. Despite important efforts, much of the statistical properties of such fluctuations remain largely unknown. This work scrutinizes these fluctuations looking at specific statistical properties which are relevant to clarify its dynamical origins. Here, three statistical features which clearly differentiate brain data from naive expectations for random processes are uncovered: First, the variance of the fMRI mean signal as a function of the number of averaged voxels remains constant across a wide range of observed clusters sizes. Second, the anomalous behavior of the variance is originated by bursts of synchronized activity across regions, regardless of their widely different sizes. Finally, the correlation length (i.e., the length at which the correlation strength between two regions vanishes) as well as mutual information diverges with the cluster's size considered, such that arbitrarily large clusters exhibit the same collective dynamics than smaller ones. These three properties are known to be exclusive of complex systems exhibiting critical dynamics, where the spatio-temporal dynamics show these peculiar type of fluctuations. Thus, these findings are fully consistent with previous reports of brain critical dynamics, and are relevant for the interpretation of the role of fluctuations and variability in brain function in health and disease. PMID:22934058

[A study on the relation between stomatognathic system and the systemic condition, concerning the influence of experimental occlusal interference on upright posture, particularly on gravity fluctuation and the antigravity muscles].

PubMed

Miyata, T

1990-06-01

The purpose of this study is to reveal the relation between stomatognathic system and the systemic condition. In the present study, experimental occlusal interference was given to the first molar on main mastication side of 6 healthy subjects and the influence on the upright posture was evaluated through simultaneous measurements of changes in activity of antigravity muscles via electromyography, other than the measurement of loci of the gravity fluctuation for stabilograph before and after the interference was provided. The following results were obtained, 1. Loci of gravity fluctuation 1) All parameters tended increase 24 hours after the interference was provided. 2) The decreasing trend was noted 24 hours after the interference was removed. 3) At one week after the interference was removed all analysis items tended to restore to the normal range. 2. Activity of antigravity muscles In some of the subjects, the muscular activity showed the same trend as the changes of analysis items of gravity fluctuation. 3. The above results suggest that the evaluation of the loci of the gravity fluctuation may be helpful to assess the therapeutic effect of malocclusion.

Does stress affect the joints? Daily stressors, stress vulnerability, immune and HPA axis activity, and short-term disease and symptom fluctuations in rheumatoid arthritis.

PubMed

Evers, Andrea W M; Verhoeven, Elisabeth W M; van Middendorp, Henriët; Sweep, Fred C G J; Kraaimaat, Floris W; Donders, A Rogier T; Eijsbouts, Agnes E; van Laarhoven, Antoinette I M; de Brouwer, Sabine J M; Wirken, Lieke; Radstake, Timothy R D J; van Riel, Piet L C M

2014-09-01

Both stressors and stress vulnerability factors together with immune and hypothalamus-pituitary-adrenal (HPA) axis activity components have been considered to contribute to disease fluctuations of chronic inflammatory diseases, such as rheumatoid arthritis (RA). The aim of the present study was to investigate whether daily stressors and worrying as stress vulnerability factor as well as immune and HPA axis activity markers predict short-term disease activity and symptom fluctuations in patients with RA. In a prospective design, daily stressors, worrying, HPA axis (cortisol) and immune system (interleukin (IL)-1β, IL-6, IL-8, interferon (IFN)-γ, tumour necrosis factor α) markers, clinical and self-reported disease activity (disease activity score in 28 joints, RA disease activity index), and physical symptoms of pain and fatigue were monitored monthly during 6 months in 80 RA patients. Multilevel modelling indicated that daily stressors predicted increased fatigue in the next month and that worrying predicted increased self-reported disease activity, swollen joint count and pain in the next month. In addition, specific cytokines of IL-1β and IFN-γ predicted increased fatigue 1 month later. Overall, relationships remained relatively unchanged after controlling for medication use, disease duration and demographic variables. No evidence was found for immune and HPA axis activity markers as mediators of the stress-disease relationship. Daily stressors and the stress-vulnerability factor worrying predict indicators of the short-term course of RA disease activity and fatigue and pain, while specific cytokines predict short-term fluctuations of fatigue. These stress-related variables and immune markers seem to affect different aspects of disease activity or symptom fluctuations independently in RA. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Survival of rapidly fluctuating natural low winter temperatures by High Arctic soil invertebrates.

PubMed

Convey, Peter; Abbandonato, Holly; Bergan, Frode; Beumer, Larissa Teresa; Biersma, Elisabeth Machteld; Bråthen, Vegard Sandøy; D'Imperio, Ludovica; Jensen, Christina Kjellerup; Nilsen, Solveig; Paquin, Karolina; Stenkewitz, Ute; Svoen, Mildrid Elvik; Winkler, Judith; Müller, Eike; Coulson, Stephen James

2015-12-01

The extreme polar environment creates challenges for its resident invertebrate communities and the stress tolerance of some of these animals has been examined over many years. However, although it is well appreciated that standard air temperature records often fail to describe accurately conditions experienced at microhabitat level, few studies have explicitly set out to link field conditions experienced by natural multispecies communities with the more detailed laboratory ecophysiological studies of a small number of 'representative' species. This is particularly the case during winter, when snow cover may insulate terrestrial habitats from extreme air temperature fluctuations. Further, climate projections suggest large changes in precipitation will occur in the polar regions, with the greatest changes expected during the winter period and, hence, implications for the insulation of overwintering microhabitats. To assess survival of natural High Arctic soil invertebrate communities contained in soil and vegetation cores to natural winter temperature variations, the overwintering temperatures they experienced were manipulated by deploying cores in locations with varying snow accumulation: No Snow, Shallow Snow (30 cm) and Deep Snow (120 cm). Air temperatures during the winter period fluctuated frequently between +3 and -24 °C, and the No Snow soil temperatures reflected this variation closely, with the extreme minimum being slightly lower. Under 30 cm of snow, soil temperatures varied less and did not decrease below -12 °C. Those under deep snow were even more stable and did not decline below -2 °C. Despite these striking differences in winter thermal regimes, there were no clear differences in survival of the invertebrate fauna between treatments, including oribatid, prostigmatid and mesostigmatid mites, Araneae, Collembola, Nematocera larvae or Coleoptera. This indicates widespread tolerance, previously undocumented for the Araneae, Nematocera or Coleoptera, of both direct exposure to at least -24 °C and the rapid and large temperature fluctuations. These results suggest that the studied polar soil invertebrate community may be robust to at least one important predicted consequence of projected climate change. Copyright © 2014 Elsevier Ltd. All rights reserved.

Entorhinal stellate cells show preferred spike phase-locking to theta inputs that is enhanced by correlations in synaptic activity

PubMed Central

Fernandez, Fernando R.; Malerba, Paola; Bressloff, Paul C.; White, John A.

2013-01-01

In active networks, excitatory and inhibitory synaptic inputs generate membrane voltage fluctuations that drive spike activity in a probabilistic manner. Despite this, some cells in vivo show a strong propensity to precisely lock to the local field potential and maintain a specific spike-phase relationship relative to other cells. In recordings from rat medial entorhinal cortical stellate cells, we measured spike phase-locking in response to sinusoidal “test” inputs in the presence of different forms of background membrane voltage fluctuations, generated via dynamic clamp. We find that stellate cells show strong and robust spike phase-locking to theta (4–12 Hz) inputs. This response occurs under a wide variety of background membrane voltage fluctuation conditions that include a substantial increase in overall membrane conductance. Furthermore, the IH current present in stellate cells is critical to the enhanced spike phase-locking response at theta. Finally, we show that correlations between inhibitory and excitatory conductance fluctuations, which can arise through feed-back and feed-forward inhibition, can substantially enhance the spike phase-locking response. The enhancement in locking is a result of a selective reduction in the size of low frequency membrane voltage fluctuations due to cancelation of inhibitory and excitatory current fluctuations with correlations. Hence, our results demonstrate that stellate cells have a strong preference for spike phase-locking to theta band inputs and that the absolute magnitude of locking to theta can be modulated by the properties of background membrane voltage fluctuations. PMID:23554484

Assessing the effects of timing irregularities on radio pulsars anomalous braking indices

NASA Astrophysics Data System (ADS)

Chukwude, A. E.; Chidi Odo, Finbarr

2016-10-01

We investigate the statistical effects of non-discrete timing irregularities on observed radio pulsar braking indices using correlations between the second derivative of the measured anomalous frequency (̈νobs) and some parameters that have been widely used to quantify pulsar timing fluctuations (the timing activity parameter (A), the amount of timing fluctuations absorbed by the cubic term (σR23) and a measure of pulsar rotational stability (σz)) in a large sample of 366 Jodrell Bank Observatory radio pulsars. The result demonstrates that anomalous braking indices are largely artifacts produced by aggregations of fluctuations that occur within or outside the pulsar system. For a subsample of 223 normal radio pulsars whose observed timing activity appeared consistent with instabilities in rotation of the underlying neutron stars (or timing noise) over timescales of ˜ 10 - 40 yr, |̈νobs| strongly correlates (with correlation coefficient |r| ˜ 0.80 - 0.90) with the pulsar timing activity parameters and spin-down properties. On the other hand, no meaningful correlations (r < 0.3) were found between ̈νobs and the timing activity diagnostics and spin-down parameters in the remaining 143 objects, whose timing activity appears significantly dominated by white noise fluctuations. The current result can be better understood if the timing noise in isolated pulsars originates from intrinsic spin-down processes of the underlying neutron stars, but white noise fluctuations largely arise from processes external to the pulsar system.

Holocene Paleolimnological Records from Thule, Northwestern Greenland

NASA Astrophysics Data System (ADS)

Corbett, L.; Osterberg, E. C.; Kelly, M. A.; Axford, Y.

2012-12-01

Assessing Holocene climatic and environmental variability around the margin of the Greenland Ice Sheet provides important information against which to compare ice sheet margin fluctuations. Here, we report preliminary results from ongoing research in northwestern Greenland. We present records of physical properties of lake sediments and use these to make inferences about the evolution of the lake and its surroundings over the latter half of the Holocene. We collected two sediment cores, 90 and 72 cm in length, from a small (surface area ~0.3 km2), shallow (maximum depth ~4.5 m) lake at 76°33'40''N 68°26'31''W near Thule Air Base in July 2012. The length of the cores was limited by the length of the core barrel and does not reflect the total thickness of sediment in the lake. The lake is situated within the glacial limit and likely formed subsequent to deglaciation of the region during early Holocene time. No glaciers exist within the lake's catchment today; the primary modern source of sediment is a perennial inflow from the west. We developed a preliminary depth-age model using radiocarbon ages of terrestrial organic macrofossils. Thus far, we have analyzed the sediments for magnetic susceptibility and loss-on-ignition. A radiocarbon age of 6069 ± 90 cal yr BP at the base of the core indicates that the sediments preserve a continuous record of middle to late Holocene conditions. The top of both cores consists of a thick (~12 cm) layer of dark gray unlaminated sediments, while the rest of the material in both cores is lighter brown to olive, finely laminated sediment. The upper layer is characterized by low water content (<25%), low loss-on-ignition (<5%), and high magnetic susceptibility (~150-250 x10-6). Conversely, the laminated sediments beneath have higher water content (~40-50%), higher loss-on-ignition (~5-10%), and much lower magnetic susceptibility (<50 x10-6). We hypothesize that the upper, less organic unit may represent a single event in the lake's recent history. We are refining the depth-age model with more radiocarbon ages, measuring grain size and carbon to nitrogen ratios of the sediments, and evaluating possible linkages between the sediment physical properties and precipitation as recorded by annual accumulation in ice cores in northwestern Greenland and Arctic Canada. This project will provide a foundation for future work in Thule investigating Holocene fluctuations of local ice cap and ice sheet margin positions.

Linear extension rates and fluctuations of trace metals in Porites sp. from around Peninsular Malaysia

NASA Astrophysics Data System (ADS)

Amir, Liyana; Mohamed, Che Abd Rahim

2018-04-01

Coral cores were collected from P. Payar, Port Dickson, P. Redang and P. Tioman. The length of cores represented data spanning from year 2009 - 2015. Satellite sea surface temperatures from year 2009 - 2015 were obtained from the Reynolds and Smith dataset. Sr/Ca concentrations were measured from the coral powder taken at 1mm intervals along the vertical growth axis. Sea Surface Temperature (SST) was significantly higher during year 2010 in all four locations and linear extension was observed to have declined in year 2010 compared to year 2009 in cores from both sites. This decline coincides with the higher SST observed in year 2010 as a result of the El Niño event. Correlation analysis showed that Sr/Ca ratios in cores from all sites have a significant inverse relationship with SST. Analysis of the trace metals such as Pb, Ba, Cr and Cu produced results that were within the reported range in coral skeleton. Concentrations were significantly higher in Port Dickson and the lowest in P. Redang. These findings could be due to differences in terrestrial input at respective reef sites.

Preliminary report on the Late Pleistocene and Holocene diatoms of Swamp Lake, Yosemite National Park, California, USA

USGS Publications Warehouse

Starratt, Scott W.; Anderson, R. Scott

2013-01-01

Swamp Lake, Yosemite National Park, is the only known lake in California containing long sequences of varved sediments and thus has the potential to provide a high-resolution record of climate variability. This preliminary analysis of the diatom assemblages from a 947-cm-long composite sediment core (freeze core FZ02–05; 0–67 cm, Livingstone core 02–05; 53–947 cm) shows that the lake has been freshwater, oligotrophic, and circumneutral to alkaline throughout its ~16,000-year-long history. The first sediments deposited in the lake show that the vegetation in the watershed was sparse, allowing organic matter-poor silt and clay to be deposited in the basin. The basin filled quickly to a depth of at least 5 m and remained at least that deep for most of the sediment record. Several short intervals provided evidence of large fluctuations in lake level during the Holocene. The upper 50 cm of the core contains evidence of the Medieval Climate Anomaly and Little Ice Age.

Molecular modeling on porphyrin derivatives as β5 subunit inhibitor of 20S proteasome.

PubMed

Arba, Muhammad; Nur-Hidayat, Andry; Ruslin; Yusuf, Muhammad; Sumarlin; Hertadi, Rukman; Wahyudi, Setyanto Tri; Surantaadmaja, Slamet Ibrahim; Tjahjono, Daryono H

2018-06-01

The ubiquitin-proteasome system plays an important role in protein quality control. Currently, inhibition of the proteasome has been validated as a promising approach in anticancer therapy. The 20S core particle of the proteasome harbors β5 subunit which is a crucial active site in proteolysis. Targeting proteasome β5 subunit which is responsible for the chymotrypsin-like activity of small molecules has been regarded as an important way for achieving therapeutics target. In the present study, a series of porphyrin derivatives bearing either pyridine or pyrazole rings as meso-substituents were designed and evaluated as an inhibitor for the β5 subunit of the proteasome by employing molecular docking and dynamics simulations. The molecular docking was performed with the help of AutoDock 4.2, while molecular dynamics simulation was done using AMBER 14. All compounds bound to the proteasome with similar binding modes, and each porphyrin-proteasome complex was stable during 30 ns MD simulation as indicated by root-mean-square-deviation (RMSD) value. An analysis on protein residue fluctuation of porphyrin binding demonstrates that in all complexes, porphyrin binding produces minor fluctuation on amino acid residues. The molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) free energy calculation shows that the binding affinities of mono-H 2 PyP, bis-H 2 PzP, and tetra-H 2 PyP were comparable with that of the potential inhibitor, HU10. It is noted that the electrostatic interaction increases with the number of meso-substituents, which was favourable for porphyrin binding. The present study shows that both electrostatic and van der Waals interaction are the main force which controls the interaction of porphyrin compounds with the proteasome. Copyright © 2018 Elsevier Ltd. All rights reserved.

The multistage crystallization of zircon in calc-alkaline granitoids: U-Pb age constraints on the timing of Variscan tectonic activity in SW Iberia

NASA Astrophysics Data System (ADS)

Pereira, M. F.; Chichorro, M.; Moita, P.; Santos, J. F.; Solá, A. M. R.; Williams, I. S.; Silva, J. B.; Armstrong, R. A.

2015-07-01

CL imaging and U-Th-Pb data for a population of zircons from two of the Évora Massif granitoids (Ossa-Morena Zone, SW Iberia) show that both calc-alkaline granitoids have zircon populations dominated by grains with cores and rims either showing or not showing differences in Th/U ratio, and having ages in the range ca. 350-335 Ma (Early Carboniferous). Multistage crystallization of zircon is revealed in two main growth stages (ca. 344-342 Ma and ca. 336-335 Ma), well represented by morphologically complex zircons with cores and rims with different ages and different Th/U ratios that can be explained by: (1) crystallization from melts with different compositions (felsic peraluminous to felsic-intermediate metaluminous; 0.001 < Th/U ratio < 0.5) and (2) transient temperature fluctuations in a system where anatectic felsic melts periodically underwent injection of more mafic magmas at higher temperatures. The two studied calc-alkaline granitoids do not include inherited zircons (pre-Carboniferous), probably because they were formed at the highest grade of metamorphism ( T > 837 °C; granulite facies) and/or because they were derived from inheritance-poor felsic and mafic rocks from a previous cycle, as suggested by the internal structures of zircon cores. These Variscan magmatic rocks with crystallization ages estimated at ca. 336-335 Ma are spatially and temporally related to high-temperature metamorphism, anatexis, processes of interaction between crustal- and mantle-derived magmas and intra-orogenic extension that acted in SW Iberia during the Early Carboniferous.

Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

PubMed Central

Winder, Aaron T.; Echagarruga, Christina; Zhang, Qingguang; Drew, Patrick J.

2017-01-01

Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest, and during whisker stimulation and volitional whisking. Here we show that neurovascular coupling was similar across states, and large spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input was blocked, and during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes. PMID:29184204

Weak correlations between hemodynamic signals and ongoing neural activity during the resting state.

PubMed

Winder, Aaron T; Echagarruga, Christina; Zhang, Qingguang; Drew, Patrick J

2017-12-01

Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. We tested this coupling by simultaneously measuring neural activity and changes in cerebral blood volume (CBV) in the somatosensory cortex of awake, head-fixed mice during periods of true rest and during whisker stimulation and volitional whisking. We found that neurovascular coupling was similar across states and that large, spontaneous CBV changes in the absence of sensory input were driven by volitional whisker and body movements. Hemodynamic signals during periods of rest were weakly correlated with neural activity. Spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking and glutamatergic input were blocked, as well as during blockade of noradrenergic receptors, suggesting a non-neuronal origin for spontaneous CBV fluctuations. Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes.

Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism

PubMed Central

Foe, Ian T.; Foster, Scott A.; Cheung, Stephanie K.; DeLuca, Steven Z.; Morgan, David O.; Toczyski, David P.

2012-01-01

SUMMARY Background Cells control progression through late mitosis by regulating Cdc20 and Cdh1, the two mitotic activators of the Anaphase Promoting Complex (APC). The control of Cdc20 protein levels during the cell cycle is not well understood. Results Here, we demonstrate that Cdc20 is degraded in budding yeast by multiple APC-dependent mechanisms. We find that the majority of Cdc20 turnover does not involve a second activator molecule, but instead depends on in cis Cdc20 autoubiquitination while it is bound to its activator-binding site on the APC core. Unlike in trans ubiquitination of Cdc20 substrates, the APC ubiquitinates Cdc20 independent of APC activation by Cdc20’s C-box. Cdc20 turnover by this intramolecular mechanism is cell cycle-regulated, contributing to the decline in Cdc20 levels that occurs after anaphase. Interestingly, high substrate levels in vitro significantly reduce Cdc20 autoubiquitination. Conclusion We show here that Cdc20 fluctuates through the cell cycle via a distinct form of APC-mediated ubiquitination. This in cis autoubiquitination may preferentially occur in early anaphase, following depletion of Cdc20 substrates. This suggests that distinct mechanisms are able to target Cdc20 for ubiquitination at different points during the cell cycle. PMID:22079111

Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy

PubMed Central

Guo, Ming; Ehrlicher, Allen J.; Jensen, Mikkel H.; Renz, Malte; Moore, Jeffrey R.; Goldman, Robert D.; Lippincott-Schwartz, Jennifer; Mackintosh, Frederick C.; Weitz, David A.

2014-01-01

SUMMARY Molecular motors in cells typically produce highly directed motion; however, the aggregate, incoherent effect of all active processes also creates randomly fluctuating forces, which drive diffusive-like, non-thermal motion. Here we introduce force-spectrum-microscopy (FSM) to directly quantify random forces within the cytoplasm of cells and thereby probe stochastic motor activity. This technique combines measurements of the random motion of probe particles with independent micromechanical measurements of the cytoplasm to quantify the spectrum of force fluctuations. Using FSM, we show that force fluctuations substantially enhance intracellular movement of small and large components. The fluctuations are three times larger in malignant cells than in their benign counterparts. We further demonstrate that vimentin acts globally to anchor organelles against randomly fluctuating forces in the cytoplasm, with no effect on their magnitude. Thus, FSM has broad applications for understanding the cytoplasm and its intracellular processes in relation to cell physiology in healthy and diseased states. PMID:25126787

Modulation of HIV Protease Flexibility by the T80N Mutation

PubMed Central

Zhou, Hao; Li, Shangyang; Badger, John; Nalivaika, Ellen; Cai, Yufeng; Foulkes-Murzycki, Jennifer; Schiffer, Celia; Makowski, Lee

2015-01-01

The flexibility of HIV protease plays a critical role in enabling enzymatic activity and is required for substrate access to the active site. While the importance of flexibility in the flaps that cover the active site is well known, flexibility in other parts of the enzyme is also critical for function. One key region is a loop containing Thr 80 which forms the walls of the active site. Although not situated within the active site, amino acid Thr80 is absolutely conserved. The mutation T80N preserves the structure of the enzyme but catalytic activity is completely lost. To investigate the potential influence of the T80N mutation on HIVp flexibility, wide-angle scattering (WAXS) data was measured for a series of HIV protease variants. Starting with a calculated WAXS pattern from a rigid atomic model, the modulations in the intensity distribution caused by structural fluctuations in the protein were predicted by simple analytic methods and compared to the experimental data. An analysis of T80N WAXS data shows that this variant is significantly more rigid than the WT across all length scales. The effects of this single point mutation extend throughout the protein, so as to alter the mobility of amino acids in the enzymatic core. These results support the contentions that significant protein flexibility extends throughout HIV protease and is critical to catalytic function. PMID:25488402

The impact of urban expansion and agricultural legacies on trace metal accumulation in fluvial and lacustrine sediments of the lower Chesapeake Bay basin, USA.

PubMed

Coxon, T M; Odhiambo, B K; Giancarlo, L C

2016-10-15

The progressively declining ecological condition of the Chesapeake Bay is attributed to the influx of contaminants associated with sediment loads supplied by its largest tributaries. The continued urban expansion in the suburbs of Virginia cities, modern agricultural activities in the Shenandoah Valley, the anthropogenic and climate driven changes in fluvial system hydrodynamics and their potential associated impacts on trace metals enrichment in the bay's tributaries necessitate constant environmental monitoring of these important water bodies. Eight (210)Pb and (137)Cs dated sediment cores and seventy two sediment grab samples were used to analyze the spatial and temporal distributions of Al, Ca, Mg, Cr, Cd, As, Se, Pb, Cu, Zn, Mn, and Fe in the waterways of the Virginia portion of the Chesapeake Bay basin. The sediment cores for trace metal historical fluctuation analysis were obtained in lower fluvial-estuarine environments and reservoirs in the upper reaches of the basin. The trace metal profiles revealed high basal enrichment factors (EF) of between 0.05 and 40.24, which are interpreted to represent early nineteenth century agricultural activity and primary resource extraction. Surficial enrichment factors on both cores and surface grab samples ranged from 0.01 (Cu) to 1421 (Cd), with Pb, Cu, Zn, and Cd enrichments a plausible consequence of modern urban expansion and industrial development along major transportation corridors. Contemporary surficial enrichments of As, Se, and Cr also ranged between 0 and 137, with the higher values likely influenced by lithological and atmospheric sources. Pearson correlation analyses suggest mining and agricultural legacies, coupled with aerosol deposition, are responsible for high metal concentrations in western lakes and headwater reaches of fluvial systems, while metal accumulation in estuarine reaches of the major rivers can be attributed to urban effluence and the remobilization of legacy sediments. Copyright © 2016 Elsevier B.V. All rights reserved.

Statistical theory of dynamo

NASA Astrophysics Data System (ADS)

Kim, E.; Newton, A. P.

2012-04-01

One major problem in dynamo theory is the multi-scale nature of the MHD turbulence, which requires statistical theory in terms of probability distribution functions. In this contribution, we present the statistical theory of magnetic fields in a simplified mean field α-Ω dynamo model by varying the statistical property of alpha, including marginal stability and intermittency, and then utilize observational data of solar activity to fine-tune the mean field dynamo model. Specifically, we first present a comprehensive investigation into the effect of the stochastic parameters in a simplified α-Ω dynamo model. Through considering the manifold of marginal stability (the region of parameter space where the mean growth rate is zero), we show that stochastic fluctuations are conductive to dynamo. Furthermore, by considering the cases of fluctuating alpha that are periodic and Gaussian coloured random noise with identical characteristic time-scales and fluctuating amplitudes, we show that the transition to dynamo is significantly facilitated for stochastic alpha with random noise. Furthermore, we show that probability density functions (PDFs) of the growth-rate, magnetic field and magnetic energy can provide a wealth of useful information regarding the dynamo behaviour/intermittency. Finally, the precise statistical property of the dynamo such as temporal correlation and fluctuating amplitude is found to be dependent on the distribution the fluctuations of stochastic parameters. We then use observations of solar activity to constrain parameters relating to the effect in stochastic α-Ω nonlinear dynamo models. This is achieved through performing a comprehensive statistical comparison by computing PDFs of solar activity from observations and from our simulation of mean field dynamo model. The observational data that are used are the time history of solar activity inferred for C14 data in the past 11000 years on a long time scale and direct observations of the sun spot numbers obtained in recent years 1795-1995 on a short time scale. Monte Carlo simulations are performed on these data to obtain PDFs of the solar activity on both long and short time scales. These PDFs are then compared with predicted PDFs from numerical simulation of our α-Ω dynamo model, where α is assumed to have both mean α0 and fluctuating α' parts. By varying the correlation time of fluctuating α', the ratio of the amplitude of the fluctuating to mean alpha <α'2>/α02 (where angular brackets <> denote ensemble average), and the ratio of poloidal to toroidal magnetic fields, we show that the results from our stochastic dynamo model can match the PDFs of solar activity on both long and short time scales. In particular, a good agreement is obtained when the fluctuation in alpha is roughly equal to the mean part with a correlation time shorter than the solar period.

Glacial greenhouse-gas fluctuations controlled by ocean circulation changes.

PubMed

Schmittner, Andreas; Galbraith, Eric D

2008-11-20

Earth's climate and the concentrations of the atmospheric greenhouse gases carbon dioxide (CO(2)) and nitrous oxide (N(2)O) varied strongly on millennial timescales during past glacial periods. Large and rapid warming events in Greenland and the North Atlantic were followed by more gradual cooling, and are highly correlated with fluctuations of N(2)O as recorded in ice cores. Antarctic temperature variations, on the other hand, were smaller and more gradual, showed warming during the Greenland cold phase and cooling while the North Atlantic was warm, and were highly correlated with fluctuations in CO(2). Abrupt changes in the Atlantic meridional overturning circulation (AMOC) have often been invoked to explain the physical characteristics of these Dansgaard-Oeschger climate oscillations, but the mechanisms for the greenhouse-gas variations and their linkage to the AMOC have remained unclear. Here we present simulations with a coupled model of glacial climate and biogeochemical cycles, forced only with changes in the AMOC. The model simultaneously reproduces characteristic features of the Dansgaard-Oeschger temperature, as well as CO(2) and N(2)O fluctuations. Despite significant changes in the land carbon inventory, CO(2) variations on millennial timescales are dominated by slow changes in the deep ocean inventory of biologically sequestered carbon and are correlated with Antarctic temperature and Southern Ocean stratification. In contrast, N(2)O co-varies more rapidly with Greenland temperatures owing to fast adjustments of the thermocline oxygen budget. These results suggest that ocean circulation changes were the primary mechanism that drove glacial CO(2) and N(2)O fluctuations on millennial timescales.

A response to "Milankovitch theory viewed from Devils Hole" by J. Imbrie, A.C. Mix and D.G. Martinson

USGS Publications Warehouse

Winograd, I.J.; Landwehr, J.M.

1993-01-01

The detailed and well-dated 500,000-yr record of oxygen-18 variations found in vein calcite core DH-11 taken from Devils Hole in Nevada provides several challenges to the Milankovitch theory for the occurrence of Quaternary glaciations. A recent discussion paper (Imbrie and others, 1993) has dismissed the relevance of this well-dated core for determining the timing of global climatic fluctuations and, moreover, asserts that the Devils Hole record provides support for the Milankovitch theory. Upon analysis of the arguments found in this discussion, the authors found nothing to dissuade them from the original conclusion that the Devils Hole chronology does present a serious challenge to the Milankovitch theory.

Decomposition of total solvation energy into core, side-chains and water contributions: Role of cross correlations and protein conformational fluctuations in dynamics of hydration layer

NASA Astrophysics Data System (ADS)

Mondal, Sayantan; Mukherjee, Saumyak; Bagchi, Biman

2017-09-01

Dynamical coupling between water and amino acid side-chain residues in solvation dynamics is investigated by selecting residues often used as natural probes, namely tryptophan, tyrosine and histidine, located at different positions on protein surface. Such differently placed residues are found to exhibit different timescales of relaxation. The total solvation response measured by the probe is decomposed in terms of its interactions with (i) protein core, (ii) side-chain and (iii) water. Significant anti cross-correlation among these contributions are observed. When the motion of the protein side-chains is quenched, solvation either becomes faster or slower depending on the location of the probe.

Radiative transfer in scattering stochastic atmospheres

NASA Astrophysics Data System (ADS)

Silant'ev, N. A.; Alekseeva, G. A.; Novikov, V. V.

2017-12-01

Many stars, active galactic nuclei, accretion discs etc. are affected by the stochastic variations of temperature, turbulent gas motions, magnetic fields, number densities of atoms and dust grains. These stochastic variations influence on the extinction factors, Doppler widths of lines and so on. The presence of many reasons for fluctuations gives rise to Gaussian distribution of fluctuations. The usual models leave out of account the fluctuations. In many cases the consideration of fluctuations improves the coincidence of theoretical values with the observed data. The objective of this paper is the investigation of the influence of the number density fluctuations on the form of radiative transfer equations. We consider non-magnetized atmosphere in continuum.

Reduction of magnetic field fluctuations in powered magnets for NMR using inductive measurements and sampled-data feedback control.

PubMed

Li, Mingzhou; Schiano, Jeffrey L; Samra, Jenna E; Shetty, Kiran K; Brey, William W

2011-10-01

Resistive and hybrid (resistive/superconducting) magnets provide substantially higher magnetic fields than those available in low-temperature superconducting magnets, but their relatively low spatial homogeneity and temporal field fluctuations are unacceptable for high resolution NMR. While several techniques for reducing temporal fluctuations have demonstrated varying degrees of success, this paper restricts attention to methods that utilize inductive measurements and feedback control to actively cancel the temporal fluctuations. In comparison to earlier studies using analog proportional control, this paper shows that shaping the controller frequency response results in significantly higher reductions in temporal fluctuations. Measurements of temporal fluctuation spectra and the frequency response of the instrumentation that cancels the temporal fluctuations guide the controller design. In particular, we describe a sampled-data phase-lead-lag controller that utilizes the internal model principle to selectively attenuate magnetic field fluctuations caused by the power supply ripple. We present a quantitative comparison of the attenuation in temporal fluctuations afforded by the new design and a proportional control design. Metrics for comparison include measurements of the temporal fluctuations using Faraday induction and observations of the effect that the fluctuations have on nuclear resonance measurements. Copyright © 2011. Published by Elsevier Inc.

High-density QCD phase transitions inside neutron stars: Glitches and gravitational waves

NASA Astrophysics Data System (ADS)

Srivastava, A. M.; Bagchi, P.; Das, A.; Layek, B.

2017-10-01

We discuss physics of exotic high baryon density QCD phases which are believed to exist in the core of a neutron star. This can provide a laboratory for exploring exotic physics such as axion emission, KK graviton production etc. Much of the physics of these high-density phases is model-dependent and not very well understood, especially the densities expected to occur inside neutron stars. We follow a different approach and use primarily universal aspects of the physics of different high-density phases and associated phase transitions. We study effects of density fluctuations during transitions with and without topological defect production and study the effect on pulsar timings due to changing moment of inertia of the star. We also discuss gravitational wave production due to rapidly changing quadrupole moment of the star due to these fluctuations.

Excitation, response, and fatigue life estimation methods for the structural design of externally blown flaps

NASA Technical Reports Server (NTRS)

Ungar, E. E.; Chandiramani, K. L.; Barger, J. E.

1972-01-01

Means for predicting the fluctuating pressures acting on externally blown flap surfaces are developed on the basis of generalizations derived from non-dimensionalized empirical data. Approaches for estimation of the fatigue lives of skin-stringer and honeycomb-core sandwich flap structures are derived from vibration response analyses and panel fatigue data. Approximate expressions for fluctuating pressures, structural response, and fatigue life are combined to reveal the important parametric dependences. The two-dimensional equations of motion of multi-element flap systems are derived in general form, so that they can be specialized readily for any particular system. An introduction is presented of an approach to characterizing the excitation pressures and structural responses which makes use of space-time spectral concepts and promises to provide useful insights, as well as experimental and analytical savings.

The fast reciprocating magnetic probe system on the J-TEXT tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Fuming; Chen, Zhipeng, E-mail: zpchen@hust.edu.cn; Zhuang, Ge

The fast reciprocating magnetic probe (FRMP) system is newly developed on the Joint Texas Experimental Tokamak (J-TEXT) to measure the local magnetic fluctuations at the plasma edge. The magnetic probe array in the FRMP consists of four 2-dimensional magnetic probes arranged at different radial locations to detect local poloidal and radial magnetic fields. These probes are protected by a graphite and boron nitride casing to improve the frequency response of each probe; they are mounted on the head of a movable rod, which is oriented along radial direction at the top of the torus. In the experiments, multiple core diagnosticsmore » show that the insertion of the FRMP has little impact on the equilibrium of the plasma. Local magnetic fluctuations inside the last closed flux surface are successfully measured by the FRMP.« less

Theory of hydrodynamic transport in fluctuating electronic charge density wave states

NASA Astrophysics Data System (ADS)

Delacrétaz, Luca V.; Goutéraux, Blaise; Hartnoll, Sean A.; Karlsson, Anna

2017-11-01

We describe the collective hydrodynamic motion of an incommensurate charge density wave state in a clean electronic system. Our description simultaneously incorporates the effects of both pinning due to weak disorder and also phase relaxation due to proliferating dislocations. We show that the interplay between these two phenomena has important consequences for charge and momentum transport. For instance, it can lead to metal-insulator transitions. We furthermore identify signatures of fluctuating density waves in frequency and spatially resolved conductivities. Phase disordering is well known to lead to a large viscosity. We derive a precise formula for the phase relaxation rate in terms of the viscosity in the dislocation cores. We thereby determine the viscosity of the superconducting state of BSCCO from the observed melting dynamics of Abrikosov lattices and show that the result is consistent with dissipation into Bogoliubov quasiparticles.

Faraday-effect polarimeter diagnostic for internal magnetic field fluctuation measurements in DIII-D.

PubMed

Chen, J; Ding, W X; Brower, D L; Finkenthal, D; Muscatello, C; Taussig, D; Boivin, R

2016-11-01

Motivated by the need to measure fast equilibrium temporal dynamics, non-axisymmetric structures, and core magnetic fluctuations (coherent and broadband), a three-chord Faraday-effect polarimeter-interferometer system with fast time response and high phase resolution has recently been installed on the DIII-D tokamak. A novel detection scheme utilizing two probe beams and two detectors for each chord results in reduced phase noise and increased time response [δb ∼ 1G with up to 3 MHz bandwidth]. First measurement results were obtained during the recent DIII-D experimental campaign. Simultaneous Faraday and density measurements have been successfully demonstrated and high-frequency, up to 100 kHz, Faraday-effect perturbations have been observed. Preliminary comparisons with EFIT are used to validate diagnostic performance. Principle of the diagnostic and first experimental results is presented.

Influence of the Solar Cycle on Turbulence Properties and Cosmic-Ray Diffusion

NASA Astrophysics Data System (ADS)

Zhao, L.-L.; Adhikari, L.; Zank, G. P.; Hu, Q.; Feng, X. S.

2018-04-01

The solar cycle dependence of various turbulence quantities and cosmic-ray (CR) diffusion coefficients is investigated by using OMNI 1 minute resolution data over 22 years. We employ Elsässer variables z ± to calculate the magnetic field turbulence energy and correlation lengths for both the inwardly and outwardly directed interplanetary magnetic field (IMF). We present the temporal evolution of both large-scale solar wind (SW) plasma variables and small-scale magnetic fluctuations. Based on these observed quantities, we study the influence of solar activity on CR parallel and perpendicular diffusion using quasi-linear theory and nonlinear guiding center theory, respectively. We also evaluate the radial evolution of the CR diffusion coefficients by using the boundary conditions for different solar activity levels. We find that in the ecliptic plane at 1 au (1), the large-scale SW temperature T, velocity V sw, Alfvén speed V A , and IMF magnitude B 0 are positively related to solar activity; (2) the fluctuating magnetic energy density < {{z}+/- }2> , residual energy E D , and corresponding correlation functions all have an obvious solar cycle dependence. The residual energy E D is always negative, which indicates that the energy in magnetic fluctuations is larger than the energy in kinetic fluctuations, especially at solar maximum; (3) the correlation length λ for magnetic fluctuations does not show significant solar cycle variation; (4) the temporally varying shear source of turbulence, which is most important in the inner heliosphere, depends on the solar cycle; (5) small-scale fluctuations may not depend on the direction of the background magnetic field; and (6) high levels of SW fluctuations will increase CR perpendicular diffusion and decrease CR parallel diffusion, but this trend can be masked if the background IMF changes in concert with turbulence in response to solar activity. These results provide quantitative inputs for both turbulence transport models and CR diffusion models, and also provide valuable insight into the long-term modulation of CRs in the heliosphere.

Ion-driven instabilities in the solar wind: Wind observations of 19 March 2005

DOE PAGES

Gary, S. Peter; Jian, Lan K.; Broiles, Thomas W.; ...

2016-01-16

Intervals of enhanced magnetic fluctuations have been frequently observed in the solar wind. However, it remains an open question as to whether these waves are generated at the Sun and then transported outward by the solar wind or generated locally in the interplanetary medium. Magnetic field and plasma measurements from the Wind spacecraft under slow solar wind conditions on 19 March 2005 demonstrate seven events of enhanced magnetic fluctuations at spacecraft-frame frequencies somewhat above the proton cyclotron frequency and propagation approximately parallel or antiparallel to the background magnetic field B o. The proton velocity distributions during these events are characterizedmore » by two components: a more dense, slower core and a less dense, faster beam. In conclusion, observed plasma parameters are used in a kinetic linear dispersion equation analysis for electromagnetic fluctuations at k x B o = 0; for two events the most unstable mode is the Alfvén-cyclotron instability driven by a proton component temperature anisotropy T ⊥/T || > 1 (where the subscripts denote directions relative to B o), and for three events the most unstable mode is the right-hand polarized magnetosonic instability driven primarily by ion component relative flows. Thus, both types of ion anisotropies and both types of instabilities are likely to be local sources of these enhanced fluctuation events in the solar wind.« less

Ion-driven instabilities in the solar wind: Wind observations of 19 March 2005

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gary, S. Peter; Jian, Lan K.; Broiles, Thomas W.

Intervals of enhanced magnetic fluctuations have been frequently observed in the solar wind. However, it remains an open question as to whether these waves are generated at the Sun and then transported outward by the solar wind or generated locally in the interplanetary medium. Magnetic field and plasma measurements from the Wind spacecraft under slow solar wind conditions on 19 March 2005 demonstrate seven events of enhanced magnetic fluctuations at spacecraft-frame frequencies somewhat above the proton cyclotron frequency and propagation approximately parallel or antiparallel to the background magnetic field B o. The proton velocity distributions during these events are characterizedmore » by two components: a more dense, slower core and a less dense, faster beam. In conclusion, observed plasma parameters are used in a kinetic linear dispersion equation analysis for electromagnetic fluctuations at k x B o = 0; for two events the most unstable mode is the Alfvén-cyclotron instability driven by a proton component temperature anisotropy T ⊥/T || > 1 (where the subscripts denote directions relative to B o), and for three events the most unstable mode is the right-hand polarized magnetosonic instability driven primarily by ion component relative flows. Thus, both types of ion anisotropies and both types of instabilities are likely to be local sources of these enhanced fluctuation events in the solar wind.« less

Ion-driven instabilities in the solar wind: Wind observations of 19 March 2005.

PubMed

Gary, S Peter; Jian, Lan K; Broiles, Thomas W; Stevens, Michael L; Podesta, John J; Kasper, Justin C

2016-01-01

Intervals of enhanced magnetic fluctuations have been frequently observed in the solar wind. But it remains an open question as to whether these waves are generated at the Sun and then transported outward by the solar wind or generated locally in the interplanetary medium. Magnetic field and plasma measurements from the Wind spacecraft under slow solar wind conditions on 19 March 2005 demonstrate seven events of enhanced magnetic fluctuations at spacecraft-frame frequencies somewhat above the proton cyclotron frequency and propagation approximately parallel or antiparallel to the background magnetic field B o . The proton velocity distributions during these events are characterized by two components: a more dense, slower core and a less dense, faster beam. Observed plasma parameters are used in a kinetic linear dispersion equation analysis for electromagnetic fluctuations at k x B o  = 0; for two events the most unstable mode is the Alfvén-cyclotron instability driven by a proton component temperature anisotropy T ⊥ /T ||  > 1 (where the subscripts denote directions relative to B o ), and for three events the most unstable mode is the right-hand polarized magnetosonic instability driven primarily by ion component relative flows. Thus, both types of ion anisotropies and both types of instabilities are likely to be local sources of these enhanced fluctuation events in the solar wind.

NIMROD Simulations of Spheromak Formation, Magnetic Reconnection and Energy Confinement in SSPX

NASA Astrophysics Data System (ADS)

Hooper, E. B.; Sovinec, C. R.

2005-10-01

The SSPX spheromak is formed and driven by a coaxial electrostatic gun that injects current and magnetic flux. Magnetic fluctuations are associated with the conversion of toroidal to poloidal magnetic flux during formation. After formation, fluctuations that break axisymmetry degrade magnetic surfaces, and are anti-correlated with the core temperature and energy confinement time. We report NIMROD simulations extending earlier work^1 supporting the SSPX experiment through predictions of performance and providing insight. The simulations are in fairly good agreement with features observed in SSPX and underscore the importance of current profile control in mitigating magnetic fluctuation amplitudes and improving confinement. The simulations yield insight into magnetic reconnection and the relationship of fluctuations to field line stochasticity. We have added external circuit equations for the new 32 module capacitor bank in SSPX that will add flexibility in shaping the injector current pulses and substantially increase the injected currents and the magnetic energy. New NIMROD simulations of SSPX lead to higher temperature plasmas than in previous simulations. *Work supported by U.S. DOE, under Contr. No. W-7405-ENG-48 at U. Cal. LLNL and under grant FG02-01ER54661 at U. Wisc Madison. ^1C. R. Sovinec, B. I. Cohen, et al., Phys. Rev. Lett. 94, 035003 (2005); B. I. Cohen, E. B. Hooper, et al., Phys. Plasmas 12, 056106 (2005).

Ion‐driven instabilities in the solar wind: Wind observations of 19 March 2005

PubMed Central

Jian, Lan K.; Broiles, Thomas W.; Stevens, Michael L.; Podesta, John J.; Kasper, Justin C.

2016-01-01

Abstract Intervals of enhanced magnetic fluctuations have been frequently observed in the solar wind. But it remains an open question as to whether these waves are generated at the Sun and then transported outward by the solar wind or generated locally in the interplanetary medium. Magnetic field and plasma measurements from the Wind spacecraft under slow solar wind conditions on 19 March 2005 demonstrate seven events of enhanced magnetic fluctuations at spacecraft‐frame frequencies somewhat above the proton cyclotron frequency and propagation approximately parallel or antiparallel to the background magnetic field B o. The proton velocity distributions during these events are characterized by two components: a more dense, slower core and a less dense, faster beam. Observed plasma parameters are used in a kinetic linear dispersion equation analysis for electromagnetic fluctuations at k x B o = 0; for two events the most unstable mode is the Alfvén‐cyclotron instability driven by a proton component temperature anisotropy T⊥/T|| > 1 (where the subscripts denote directions relative to B o), and for three events the most unstable mode is the right‐hand polarized magnetosonic instability driven primarily by ion component relative flows. Thus, both types of ion anisotropies and both types of instabilities are likely to be local sources of these enhanced fluctuation events in the solar wind. PMID:27818854

Effects of redox fluctuations on microbial community ecology post-wildfire in a high elevation mixed-conifer catchment in northern New Mexico.

NASA Astrophysics Data System (ADS)

Fairbanks, D.; Green, K.; Murphy, M. A.; Shepard, C.; Chorover, J.; Rich, V. I.; Gallery, R. E.

2015-12-01

Wildfires are increasing in size and severity across the western United States with impacts on regional biogeochemical cycling. The resiliency of resident soil microbial communities determines rates of nutrient transformations as well as forest structure and recovery. Redox conditions in soil determine metabolic activities of microorganisms, which first consume oxygen and a succession of alternative terminal electron acceptors to support growth and metabolism using a variety of carbon sources. Controls on redox zonation are largely unknown in dominantly oxic soils, and microbial community adaptation and response to fluctuations in redox potential in a sub-alpine forested post-disturbance catchment has not been studied. Previous work has shown that fluctuating or rising water tables result in redox-dynamic sites, which can be 'hot spots' of biogeochemical activity depending on landscape position. Fire-induced tree mortality results in altered hydrologic flow paths and decreased evapotranspiration, leading to potential for intensified hot spot activity. We are testing such coupling of microbial activity with fluctuations in redox status using field measurements and laboratory incubation experiments. The 2013 Thompson Ridge Fire in the Jemez River Basin (NM) Critical Zone Observatory provides a highly-contextualized opportunity to examine how disturbance regime affects changes in soil microbial community dynamics and fluctuations in reduction-oxidation potential (as quantified by continuous CZO measurements of O2, CO2 and Eh as a function of soil depth and landscape location). We hypothesize that areas of depositional convergence in the catchment, which have been shown to exhibit more reducing conditions, will host microbial communities that are better adapted to fluctuating redox conditions and exhibit a greater diversity in functional capabilities. In these mixed conifer forests we find shifts in redox potential status in relation to depth and topography where more reducing conditions typically occur in convergent zones and at depth. These results highlight the significance of fluctuating oxygen-depleted zones in aerobic soils on microbial community activity and structure, linking community response to larger scale ecosystem processes.

Narrow linewidth short cavity Brillouin random laser based on Bragg grating array fiber and dynamical population inversion gratings

NASA Astrophysics Data System (ADS)

Popov, S. M.; Butov, O. V.; Chamorovski, Y. K.; Isaev, V. A.; Mégret, P.; Korobko, D. A.; Zolotovskii, I. O.; Fotiadi, A. A.

2018-06-01

We report on random lasing observed with 100-m-long fiber comprising an array of weak FBGs inscribed in the fiber core and uniformly distributed over the fiber length. Extended fluctuation-free oscilloscope traces highlight power dynamics typical for lasing. An additional piece of Er-doped fiber included into the laser cavity enables a stable laser generation with a linewidth narrower than 10 kHz.

Large scale motions of multiple limit-cycle high Reynolds number annular and toroidal rotor/stator cavities

NASA Astrophysics Data System (ADS)

Bridel-Bertomeu, Thibault; Gicquel, L. Y. M.; Staffelbach, G.

2017-06-01

Rotating cavity flows are essential components of industrial applications but their dynamics are still not fully understood when it comes to the relation between the fluid organization and monitored pressure fluctuations. From computer hard-drives to turbo-pumps of space launchers, designed devices often produce flow oscillations that can either destroy the component prematurely or produce too much noise. In such a context, large scale dynamics of high Reynolds number rotor/stator cavities need better understanding especially at the flow limit-cycle or associated statistically stationary state. In particular, the influence of curvature as well as cavity aspect ratio on the large scale organization and flow stability at a fixed rotating disc Reynolds number is fundamental. To probe such flows, wall-resolved large eddy simulation is applied to two different rotor/stator cylindrical cavities and one annular cavity. Validation of the predictions proves the method to be suited and to capture the disc boundary layer patterns reported in the literature. It is then shown that in complement to these disc boundary layer analyses, at the limit-cycle the rotating flows exhibit characteristic patterns at mid-height in the homogeneous core pointing the importance of large scale features. Indeed, dynamic modal decomposition reveals that the entire flow dynamics are driven by only a handful of atomic modes whose combination links the oscillatory patterns observed in the boundary layers as well as in the core of the cavity. These fluctuations form macro-structures, born in the unstable stator boundary layer and extending through the homogeneous inviscid core to the rotating disc boundary layer, causing its instability under some conditions. More importantly, the macro-structures significantly differ depending on the configuration pointing the need for deeper understanding of the influence of geometrical parameters as well as operating conditions.

Seismic attenuation of the inner core: Viscoelastic or stratigraphic?

USGS Publications Warehouse

Cormier, V.F.; Xu, L.; Choy, G.L.

1998-01-01

Broadband velocity waveforms of PKIKP in the distance range 150??to 180??are inverted for inner core attenuation. A mean Q?? of 244 is determined at 1 Hz from 8 polar and 9 equatorial paths. The scatter in measured Q-1 exceeds individual error estimates, suggesting significant variation in attenuation with path. These results are interpreted by (1) viscoelasticity, in which the relaxation spectrum has a low-frequency corner near or slightly above the frequency band of short-period body waves, and by (2) stratigraphic (scattering) attenuation, in which attenuation and pulse broadening are caused by the interference of scattered multiples in a velocity structure having rapid fluctuations along a PKIKP path. In the scattering interpretation, PKIKP attenuation is only weakly affected by the intrinsic shear attenuation measured in the free-oscillation band. Instead, its frequency dependence, path variations, and fluctuations are all explained by scattering attenuation in a heterogeneous fabric resulting from solidification texturing of intrinsically anisotropic iron. The requisite fabric may consist of either single or ordered groups of crystals with P velocity differences of at least 5% and as much as 12% between two crystallographic axes at scale lengths of 0.5 to 2 km in the direction parallel to the axis of rotation and longer in the cylindrically radial direction, perpendicular to the axis of rotation.Broadband velocity waveforms of PKIKP in the distance range 150?? to 180?? are inverted for inner core attenuation. A mean Q?? of 244 is determined at 1 Hz from 8 polar and 9 equatorial paths. The scatter in the measured Q-1 exceeds individual error estimates, indicating significant variation in attenuation with path. The results are interpreted by viscoelasticity and stratigraphic (scattering) attenuation.

Density fluctuation correlation measurements in ASDEX Upgrade using poloidal and radial correlation reflectometry

NASA Astrophysics Data System (ADS)

Prisiazhniuk, D.; Conway, G. D.; Krämer-Flecken, A.; Stroth, U.; the ASDEX Upgrade Team

2018-07-01

The poloidal correlation reflectometry diagnostic operated in ordinary mode with additional radial correlation channel is applied in this paper to investigate the correlation of the turbulent density fluctuations. The perpendicular and radial correlation lengths, l ⊥ and l r , the perpendicular velocity v⊥ and the dissipation (mutation) time τ d are measured simultaneously from the outer core to edge in the L-mode plasmas of ASDEX Upgrade. It is shown that in the outer core region (0.6 < ρ pol < 0.9) the measured correlation lengths scale with the drift wave length, l ⊥ ≈ 5ρ s and l r ≈ 10ρ s , while the dissipation time is inversely correlated with the velocity τ d ≈ 40/v ⊥(τ d is in μs and v ⊥ in km s–1). In the pedestal region (0.925 < ρ pol < 0.98), where the E × B shear flows are present, a loss of measured correlation is observed which can be explained by a combination of small propagation velocity and an additional reduction of τ d . In the E r well region (ρ pol ≈ 0.99), the measured perpendicular correlation length increases {l}\\perp ≈ 13{ρ }s and the radial correlation length decreases l r ≈ 4ρ s compared to the outer core values. The correlation measurements are interpreted in the frame of the linear regime of reflectometry (applied only to ρ pol < 0.9). Using the Born approximation we show that the finite wavenumber sensitivity of the reflectometer increases the measured l ⊥and l r , but does not affect the measured τ d . By the including diagnostic correction the real correlation lengths l ⊥ ≈ l r ≈ 3ρ s are estimated.

Sequence stratigraphic principles applied to the Miocene Hawthorn Group, west-central Florida

DOE Office of Scientific and Technical Information (OSTI.GOV)

Norton, V.L.; Randazzo, A.F.

1993-03-01

Sequence boundaries for the Miocene Hawthorn Group in the ROMP 20 drill core from Osprey, Sarasota County, FL were generally delineated by lithologic variations recognized from core slabs, thin section analysis, and geophysical logs. At least six depositional sequences representing third order sea level fluctuations were identified. Depositional environments were determined on the basis of the characteristic lithologic constituents including rip-up clasts, pellets, fossils, laminations, burrow, degree of induration, and grain sorting. The sequence boundaries appear to have formed when the rate of the eustatic fall exceeded basin subsidence rates producing a relative sea level fall at a depositional shorelinemore » break. As a result of the basinward facies shift associated with this sequence type, peritidal facies may directly overlie deeper water facies. Subaerial exposure and erosion can be expected. The sequence of facies representing progressively deeper water depositional environments, followed by a progressive shallowing, were present between bounding surfaces. Among the six sequences recognized, four were clearly delineated as representative of regression, subaerial exposure, and subsequent transgression. Two sequences were less clearly defined and probably represent transitional facies which had exposure surfaces developed. Comparison of the petrologically established sequence stratigraphy with published sea level curves resulted in a strong correlation between the number of sequences recognized and the number of coastal on-lap/off-lap cycles depicted for the early to middle Miocene. This correlation suggests that petrologic examination of core slabs, with supplemental thin section data, can provide useful information regarding the recognition of stratigraphic sequences and relative sea level fluctuations, particularly, in situations where seismic data may not be available.« less

Spontaneous voltage and current fluctuations in tissue cultured mouse dorsal root ganglion cells.

PubMed

Mathers, D A; Barker, J L

1984-02-13

Fetal mouse dorsal root ganglion (DRG) neurons were maintained in primary dissociated cell culture for periods of 7 days to 3 months. Intracellular recordings from these cells revealed the presence of spontaneous subthreshold potentials in 101/177 neurons studied. When measured at the resting membrane potential, these spontaneous voltage events took two forms: (a) high frequency potential fluctuations several millivolts in peak-to-peak amplitude and (b) small, discrete hyperpolarizations. Neurons exhibiting either type of event were designated as 'active' DRG cells. No spontaneous potentials were seen in DRG cells hyperpolarized to membrane voltages more negative than -64 +/- 11.5 mV (n = 5 cells). Under voltage-clamp conditions, the subthreshold potentials of active DRG cells were replaced by fluctuations in outward current. The power spectral density, S(f) of these current fluctuations was approximated by an equation of the form S(f) = (S(o)/[1 + (f/fc) alpha] where 2 less than or equal to a less than or equal to 3 and the half-power frequency fc = 11.3 +/- 3.1 Hz at 23 degrees C (n = 17 cells). The spontaneous voltage fluctuations of active DRG cells were abolished in Ca2+-free saline, and of the divalent metal cations Sr2+, Mg2+, Ba2+, Co2+ and Mn2+, only Sr2+ could substitute for Ca2+ in the maintenance of this activity. Tetraethylammonium ions (1-10 mM) reversibly blocked the spontaneous potentials, while caffeine (10 mM) increased the frequency of these events. The spontaneous voltage fluctuations were not dependent on the presence of spinal cord neurons in the culture plate, and they were also observed in cultured DRG cells derived from adult mice.

Large-Scale Chaos and Fluctuations in Active Nematics

NASA Astrophysics Data System (ADS)

Ngo, Sandrine; Peshkov, Anton; Aranson, Igor S.; Bertin, Eric; Ginelli, Francesco; Chaté, Hugues

2014-07-01

We show that dry active nematics, e.g., collections of shaken elongated granular particles, exhibit large-scale spatiotemporal chaos made of interacting dense, ordered, bandlike structures in a parameter region including the linear onset of nematic order. These results are obtained from the study of both the well-known (deterministic) hydrodynamic equations describing these systems and of the self-propelled particle model they were derived from. We prove, in particular, that the chaos stems from the generic instability of the band solution of the hydrodynamic equations. Revisiting the status of the strong fluctuations and long-range correlations in the particle model, we show that the giant number fluctuations observed in the chaotic phase are a trivial consequence of density segregation. However anomalous, curvature-driven number fluctuations are present in the homogeneous quasiordered nematic phase and characterized by a nontrivial scaling exponent.

Time-resolved microrheology of actively remodeling actomyosin networks

NASA Astrophysics Data System (ADS)

Silva, Marina Soares e.; Stuhrmann, Björn; Betz, Timo; Koenderink, Gijsje H.

2014-07-01

Living cells constitute an extraordinary state of matter since they are inherently out of thermal equilibrium due to internal metabolic processes. Indeed, measurements of particle motion in the cytoplasm of animal cells have revealed clear signatures of nonthermal fluctuations superposed on passive thermal motion. However, it has been difficult to pinpoint the exact molecular origin of this activity. Here, we employ time-resolved microrheology based on particle tracking to measure nonequilibrium fluctuations produced by myosin motor proteins in a minimal model system composed of purified actin filaments and myosin motors. We show that the motors generate spatially heterogeneous contractile fluctuations, which become less frequent with time as a consequence of motor-driven network remodeling. We analyze the particle tracking data on different length scales, combining particle image velocimetry, an ensemble analysis of the particle trajectories, and finally a kymograph analysis of individual particle trajectories to quantify the length and time scales associated with active particle displacements. All analyses show clear signatures of nonequilibrium activity: the particles exhibit random motion with an enhanced amplitude compared to passive samples, and they exhibit sporadic contractile fluctuations with ballistic motion over large (up to 30 μm) distances. This nonequilibrium activity diminishes with sample age, even though the adenosine triphosphate level is held constant. We propose that network coarsening concentrates motors in large clusters and depletes them from the network, thus reducing the occurrence of contractile fluctuations. Our data provide valuable insight into the physical processes underlying stress generation within motor-driven actin networks and the analysis framework may prove useful for future microrheology studies in cells and model organisms.

Fluctuations of conserved charges in relativistic heavy ion collisions: An introduction

NASA Astrophysics Data System (ADS)

Asakawa, Masayuki; Kitazawa, Masakiyo

2016-09-01

Bulk fluctuations of conserved charges measured by event-by-event analysis in relativistic heavy ion collisions are observables which are believed to carry significant amount of information on the hot medium created by the collisions. Active studies have been done recently experimentally, theoretically, and on the lattice. In particular, non-Gaussianity of the fluctuations has acquired much attention recently. In this review, we give a pedagogical introduction to these issues, and survey recent developments in this field of research. Starting from the definition of cumulants, basic concepts in fluctuation physics, such as thermal fluctuations in statistical mechanics and time evolution of fluctuations in diffusive systems, are described. Phenomena which are expected to occur in finite temperature and/or density QCD matter and their measurement by event-by-event analyses are also elucidated.

Active processes make mixed lipid membranes either flat or crumpled

NASA Astrophysics Data System (ADS)

Banerjee, Tirthankar; Basu, Abhik

2018-01-01

Whether live cell membranes show miscibility phase transitions (MPTs), and if so, how they fluctuate near the transitions remain outstanding unresolved issues in physics and biology alike. Motivated by these questions we construct a generic hydrodynamic theory for lipid membranes that are active, due for instance, to the molecular motors in the surrounding cytoskeleton, or active protein components in the membrane itself. We use this to uncover a direct correspondence between membrane fluctuations and MPTs. Several testable predictions are made: (i) generic active stiffening with orientational long range order (flat membrane) or softening with crumpling of the membrane, controlled by the active tension and (ii) for mixed lipid membranes, capturing the nature of putative MPTs by measuring the membrane conformation fluctuations. Possibilities of both first and second order MPTs in mixed active membranes are argued for. Near second order MPTs, active stiffening (softening) manifests as a super-stiff (super-soft) membrane. Our predictions are testable in a variety of in vitro systems, e.g. live cytoskeletal extracts deposited on liposomes and lipid membranes containing active proteins embedded in a passive fluid.

On the origin of shape fluctuations of the cell nucleus.

PubMed

Chu, Fang-Yi; Haley, Shannon C; Zidovska, Alexandra

2017-09-26

The nuclear envelope (NE) presents a physical boundary between the cytoplasm and the nucleoplasm, sandwiched in between two highly active systems inside the cell: cytoskeleton and chromatin. NE defines the shape and size of the cell nucleus, which increases during the cell cycle, accommodating for chromosome decondensation followed by genome duplication. In this work, we study nuclear shape fluctuations at short time scales of seconds in human cells. Using spinning disk confocal microscopy, we observe fast fluctuations of the NE, visualized by fluorescently labeled lamin A, and of the chromatin globule surface (CGS) underneath the NE, visualized by fluorescently labeled histone H2B. Our findings reveal that fluctuation amplitudes of both CGS and NE monotonously decrease during the cell cycle, serving as a reliable cell cycle stage indicator. Remarkably, we find that, while CGS and NE typically fluctuate in phase, they do exhibit localized regions of out-of-phase motion, which lead to separation of NE and CGS. To explore the mechanism behind these shape fluctuations, we use biochemical perturbations. We find the shape fluctuations of CGS and NE to be both thermally and actively driven, the latter caused by forces from chromatin and cytoskeleton. Such undulations might affect gene regulation as well as contribute to the anomalously high rates of nuclear transport by, e.g., stirring of molecules next to NE, or increasing flux of molecules through the nuclear pores.

EUCLIA—Exploring the UV/Optical Continuum Lag in Active Galactic Nuclei. I. A Model without Light Echoing

NASA Astrophysics Data System (ADS)

Cai, Zhen-Yi; Wang, Jun-Xian; Zhu, Fei-Fan; Sun, Mou-Yuan; Gu, Wei-Min; Cao, Xin-Wu; Yuan, Feng

2018-03-01

The tight interband correlation and the lag–wavelength relation among UV/optical continua of active galactic nuclei have been firmly established. They are usually understood within the widespread reprocessing scenario; however, the implied interband lags are generally too small. Furthermore, it is challenged by new evidence, such as that the X-ray reprocessing yields too much high-frequency UV/optical variation and that it fails to reproduce the observed timescale-dependent color variations among the Swift light curves of NGC 5548. In a different manner, we demonstrate that an upgraded inhomogeneous accretion disk model, whose local independent temperature fluctuations are subject to a speculated common large-scale temperature fluctuation, can intrinsically generate the tight interband correlation and lag across the UV/optical and be in nice agreement with several observational properties of NGC 5548, including the timescale-dependent color variation. The emergent lag is a result of the differential regression capability of local temperature fluctuations when responding to the large-scale fluctuation. An average speed of propagations as large as ≳15% of the speed of light may be required by this common fluctuation. Several potential physical mechanisms for such propagations are discussed. Our interesting phenomenological scenario may shed new light on comprehending the UV/optical continuum variations of active galactic nuclei.

Predicting Pharmacokinetic Stability by Multiple Oral Administration of Atypical Antipsychotics

PubMed Central

Aoki, Kazuo; Sakiyama, Yojiro; Ohnishi, Takashi; Sugita, Makoto

2013-01-01

Lower fluctuation, i.e., lower peak-to-trough plasma-concentration variation at steady-state pharmacokinetics, has several advantages for the treatment of schizophrenia with antipsychotics. The reduction of peak concentration can decrease the risk of dose-dependent side effects, such as extrapyramidal symptom and somnolence, and by contrast the increase in trough concentration can decrease the incidence of lack of efficacy due to subtherapeutic drug concentration. Using a one-compartment simulation technique with pharmacokinetic parameters of each atypical antipsychotic collected from package inserts, the fluctuation index was calculated. Among the antipsychotics, the indices varied from 0.018 to 1.9, depending on dosing regimens, formulations and several pharmacokinetic properties. The order of simulated fluctuation index is active-moiety aripiprazole (b.i.d.)

Neuronal Substrates Underlying Performance Variability in Well-Trained Skillful Motor Task in Humans.

PubMed

Mizuguchi, Nobuaki; Uehara, Shintaro; Hirose, Satoshi; Yamamoto, Shinji; Naito, Eiichi

2016-01-01

Motor performance fluctuates trial by trial even in a well-trained motor skill. Here we show neural substrates underlying such behavioral fluctuation in humans. We first scanned brain activity with functional magnetic resonance imaging while healthy participants repeatedly performed a 10 s skillful sequential finger-tapping task. Before starting the experiment, the participants had completed intensive training. We evaluated task performance per trial (number of correct sequences in 10 s) and depicted brain regions where the activity changes in association with the fluctuation of the task performance across trials. We found that the activity in a broader range of frontoparietocerebellar network, including the bilateral dorsolateral prefrontal cortex (DLPFC), anterior cingulate and anterior insular cortices, and left cerebellar hemisphere, was negatively correlated with the task performance. We further showed in another transcranial direct current stimulation (tDCS) experiment that task performance deteriorated, when we applied anodal tDCS to the right DLPFC. These results indicate that fluctuation of brain activity in the nonmotor frontoparietocerebellar network may underlie trial-by-trial performance variability even in a well-trained motor skill, and its neuromodulation with tDCS may affect the task performance.

The influence of autonomic interventions on the sleep-wake-related changes in gastric myoelectrical activity in rats.

PubMed

Huang, Y M; Yang, C C H; Lai, C J; Kuo, T B J

2011-06-01

Significant changes in autonomic activity occur at sleep-wake transitions and constitute an ideal setting for investigating the modulatory role of the autonomic nervous system on gastric myoelectrical activity (GMA). Using continuous power spectral analysis of electroencephalogram, electromyogram, and electrogastromyogram (EGMG) data from freely moving rats that had undergone chemical sympathetomy and/or truncal vagotomy, sleep-wake-related fluctuations in GMA were compared among the intervention groups. The pattern and extent of fluctuations in EGMG power across the sleep-wake states was blunted most significantly in rats undergoing both chemical sympathectomy and truncal vagotomy. The effect of these interventions also varied with respect to the transition between different sleep-wake states. The most prominent influences were observed between active waking and quiet sleep and between paradoxical sleep and quiet sleep. The sleep-wake-related fluctuations in EGMG power are a result of joint contributions from both sympathetic and vagal innervation. Vagotomy mainly resulted in a reduction in EGMG power, while the role of sympathetic innervation was unveiled by vagotomy and this was reflected most obviously in the extent of the fluctuations in EGMG power. © 2011 Blackwell Publishing Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Z. Y., E-mail: zychen@hust.edu.cn; Huang, D. W.; Tong, R. H.

The measurement of internal magnetic fluctuation is important for the study of transport in tokamak plasmas. The runaway electron transport induced by the sawtooth crash can be used to obtain the internal magnetic fluctuation. Inversed sawtooth-like activities on hard x-ray (HXR) fluxes following sawtooth activities were observed after the application of electrode biasing on J-TEXT tokamak. The runaway diffusion coefficient D{sub r} is deduced to be about 30 m{sup 2}/s according to the time delay of HXR flux peaks to the sawtooth crashes. The averaged value of normalized magnetic fluctuation in the discharges with electrode biasing was increased to themore » order of 1 × 10{sup −4}.« less

Motor contributions to the temporal precision of auditory attention

PubMed Central

Morillon, Benjamin; Schroeder, Charles E.; Wyart, Valentin

2014-01-01

In temporal—or dynamic—attending theory, it is proposed that motor activity helps to synchronize temporal fluctuations of attention with the timing of events in a task-relevant stream, thus facilitating sensory selection. Here we develop a mechanistic behavioural account for this theory by asking human participants to track a slow reference beat, by noiseless finger pressing, while extracting auditory target tones delivered on-beat and interleaved with distractors. We find that overt rhythmic motor activity improves the segmentation of auditory information by enhancing sensitivity to target tones while actively suppressing distractor tones. This effect is triggered by cyclic fluctuations in sensory gain locked to individual motor acts, scales parametrically with the temporal predictability of sensory events and depends on the temporal alignment between motor and attention fluctuations. Together, these findings reveal how top-down influences associated with a rhythmic motor routine sharpen sensory representations, enacting auditory ‘active sensing’. PMID:25314898

Motor contributions to the temporal precision of auditory attention.

PubMed

Morillon, Benjamin; Schroeder, Charles E; Wyart, Valentin

2014-10-15

In temporal-or dynamic-attending theory, it is proposed that motor activity helps to synchronize temporal fluctuations of attention with the timing of events in a task-relevant stream, thus facilitating sensory selection. Here we develop a mechanistic behavioural account for this theory by asking human participants to track a slow reference beat, by noiseless finger pressing, while extracting auditory target tones delivered on-beat and interleaved with distractors. We find that overt rhythmic motor activity improves the segmentation of auditory information by enhancing sensitivity to target tones while actively suppressing distractor tones. This effect is triggered by cyclic fluctuations in sensory gain locked to individual motor acts, scales parametrically with the temporal predictability of sensory events and depends on the temporal alignment between motor and attention fluctuations. Together, these findings reveal how top-down influences associated with a rhythmic motor routine sharpen sensory representations, enacting auditory 'active sensing'.

A hetero-core fiber optic smart mat sensor for discrimination between a moving human and object on temporal loss peaks

NASA Astrophysics Data System (ADS)

Hosoki, Ai; Nishiyama, Michiko; Choi, Yongwoon; Watanabe, Kazuhiro

2011-05-01

In this paper, we propose discrimination method between a moving human and object by means of a hetero-core fiber smart mat sensor which induces the optical loss change in time. In addition to several advantages such as flexibility, thin size and resistance to electro-magnetic interference for a fiber optic sensor, a hetero-core fiber optic sensor is sensitive to bending action of the sensor portion and independent of temperature fluctuations. Therefore, the hetero-core fiber thin mat sensor can have a fewer sensing portions than the conventional floor pressure sensors, furthermore, can detect the wide area covering the length of strides. The experimental results for human walking tests showed that the mat sensors were reproducibly working in real-time under limiting locations the foot passed in the mat sensor. Focusing on the temporal peak numbers in the optical loss, human walking and wheeled platform moving action induced the peak numbers in the range of 1 - 3 and 5 - 7, respectively, for the 10 persons including 9 male and 1 female. As a result, we conclude that the hetero-core fiber mat sensor is capable of discriminating between the moving human and object such as a wheeled platform focusing on the peak numbers in the temporal optical loss.

(210)Pb and composition data of near-surface sediments and interstitial waters evidencing anthropogenic inputs in Amazon River mouth, Macapá, Brazil.

PubMed

Nery, José Reinaldo Cardoso; Bonotto, Daniel Marcos

2011-04-01

Activity profiles of excess (210)Pb determined in three sediment cores from Amazon River mouth, Macapá city, Brazil, provided the evaluation of sedimentation rates, contributing to a better knowledge of the hydrological conditions in the site that is the capital of Amapá State and is drained by the waters of the huge Amazon River. Chemical data were also determined in the sediments, allowing identify signatures coupled to anthropogenic inputs held in the past in Amapá State. Significant direct relationships between LOI (loss on ignition) and organic matter were found for all sediments profiles. Silica was found to be inversely related to organic matter in the three profiles; its decrease accompanied an increase on the specific surface of the sediments. This relationship was confirmed by a great number of inverse significant correlations among silica and oxides Na(2)O, K(2)O, CaO, MgO, Al(2)O(3), P(2)O(5), Fe(2)O(3) and MnO. It was possible to identify the role of organic matter on adsorption of several oxides in the core sediments profiles. Apparent sediment mass accumulation rates corresponding to values between 450 and 2510 mg cm(-2)yr(-1) were obtained, and are compatible with the results of others studies. The (210)Pb activities in one sampling point suggested the occurrence of anthropogenic inputs related to the initial period of the mining activities conducted in Serra do Navio, Amapá State, for the commercialization of Mn ores. This was reinforced by the abrupt fluctuations in chemical data obtained for the sediments and composition of the interstitial waters occurring there. The Atlantic hurricane activity also appeared to affect the sedimentation rates in the area, as two different values were recorded in each profile. Copyright © 2011 Elsevier Ltd. All rights reserved.

THE DEPENDENCE OF PRESTELLAR CORE MASS DISTRIBUTIONS ON THE STRUCTURE OF THE PARENTAL CLOUD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parravano, Antonio; Sanchez, Nestor; Alfaro, Emilio J.

2012-08-01

The mass distribution of prestellar cores is obtained for clouds with arbitrary internal mass distributions using a selection criterion based on the thermal and turbulent Jeans mass and applied hierarchically from small to large scales. We have checked this methodology by comparing our results for a log-normal density probability distribution function with the theoretical core mass function (CMF) derived by Hennebelle and Chabrier, namely a power law at large scales and a log-normal cutoff at low scales, but our method can be applied to any mass distributions representing a star-forming cloud. This methodology enables us to connect the parental cloudmore » structure with the mass distribution of the cores and their spatial distribution, providing an efficient tool for investigating the physical properties of the molecular clouds that give rise to the prestellar core distributions observed. Simulated fractional Brownian motion (fBm) clouds with the Hurst exponent close to the value H = 1/3 give the best agreement with the theoretical CMF derived by Hennebelle and Chabrier and Chabrier's system initial mass function. Likewise, the spatial distribution of the cores derived from our methodology shows a surface density of companions compatible with those observed in Trapezium and Ophiucus star-forming regions. This method also allows us to analyze the properties of the mass distribution of cores for different realizations. We found that the variations in the number of cores formed in different realizations of fBm clouds (with the same Hurst exponent) are much larger than the expected root N statistical fluctuations, increasing with H.« less

Self powered neutron detectors as in-core detectors for Sodium-cooled Fast Reactors

NASA Astrophysics Data System (ADS)

Verma, V.; Barbot, L.; Filliatre, P.; Hellesen, C.; Jammes, C.; Svärd, S. Jacobsson

2017-07-01

Neutron flux monitoring system forms an integral part of the design of a Generation IV sodium cooled fast reactor. Diverse possibilities of detector system installation must be studied for various locations in the reactor vessel in order to detect any perturbations in the core. Results from a previous paper indicated that it is possible to detect changes in neutron source distribution initiated by an inadvertent withdrawal of outer control rod with in-vessel fission chambers located azimuthally around the core. It is, however, not possible to follow inner control rod withdrawal and precisely know the location of the perturbation in the core. Hence the use of complimentary in-core detectors coupled with the peripheral fission chambers is proposed to enable robust core monitoring across the radial direction. In this paper, we assess the feasibility of using self-powered neutron detectors (SPNDs) as in-core detectors in fast reactors for detecting local changes in the power distribution when the reactor is operated at nominal power. We study the neutron and gamma contributions to the total output current of the detector modelled with Platinum as the emitter material. It is shown that this SPND placed in an SFR-like environment would give a sufficiently measurable prompt neutron induced current of the order of 600 nA/m. The corresponding induced current in the connecting cable is two orders of magnitude lower and can be neglected. This means that the SPND can follow in-core power fluctuations. This validates the operability of an SPND in an SFR-like environment.

The Dependence of Prestellar Core Mass Distributions on the Structure of the Parental Cloud

NASA Astrophysics Data System (ADS)

Parravano, Antonio; Sánchez, Néstor; Alfaro, Emilio J.

2012-08-01

The mass distribution of prestellar cores is obtained for clouds with arbitrary internal mass distributions using a selection criterion based on the thermal and turbulent Jeans mass and applied hierarchically from small to large scales. We have checked this methodology by comparing our results for a log-normal density probability distribution function with the theoretical core mass function (CMF) derived by Hennebelle & Chabrier, namely a power law at large scales and a log-normal cutoff at low scales, but our method can be applied to any mass distributions representing a star-forming cloud. This methodology enables us to connect the parental cloud structure with the mass distribution of the cores and their spatial distribution, providing an efficient tool for investigating the physical properties of the molecular clouds that give rise to the prestellar core distributions observed. Simulated fractional Brownian motion (fBm) clouds with the Hurst exponent close to the value H = 1/3 give the best agreement with the theoretical CMF derived by Hennebelle & Chabrier and Chabrier's system initial mass function. Likewise, the spatial distribution of the cores derived from our methodology shows a surface density of companions compatible with those observed in Trapezium and Ophiucus star-forming regions. This method also allows us to analyze the properties of the mass distribution of cores for different realizations. We found that the variations in the number of cores formed in different realizations of fBm clouds (with the same Hurst exponent) are much larger than the expected root {\\cal N} statistical fluctuations, increasing with H.

The neural basis of trait self-esteem revealed by the amplitude of low-frequency fluctuations and resting state functional connectivity.

PubMed

Pan, Weigang; Liu, Congcong; Yang, Qian; Gu, Yan; Yin, Shouhang; Chen, Antao

2016-03-01

Self-esteem is an affective, self-evaluation of oneself and has a significant effect on mental and behavioral health. Although research has focused on the neural substrates of self-esteem, little is known about the spontaneous brain activity that is associated with trait self-esteem (TSE) during the resting state. In this study, we used the resting-state functional magnetic resonance imaging (fMRI) signal of the amplitude of low-frequency fluctuations (ALFFs) and resting state functional connectivity (RSFC) to identify TSE-related regions and networks. We found that a higher level of TSE was associated with higher ALFFs in the left ventral medial prefrontal cortex (vmPFC) and lower ALFFs in the left cuneus/lingual gyrus and right lingual gyrus. RSFC analyses revealed that the strengths of functional connectivity between the left vmPFC and bilateral hippocampus were positively correlated with TSE; however, the connections between the left vmPFC and right inferior frontal gyrus and posterior superior temporal sulcus were negatively associated with TSE. Furthermore, the strengths of functional connectivity between the left cuneus/lingual gyrus and right dorsolateral prefrontal cortex and anterior cingulate cortex were positively related to TSE. These findings indicate that TSE is linked to core regions in the default mode network and social cognition network, which is involved in self-referential processing, autobiographical memory and social cognition. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Fluctuation - a common but neglected pattern of physical activity behaviour: An exploratory review of studies in recent 20 years.

PubMed

Shang, Borui; Duan, Yanping; Huang, Wendy Yajun; Brehm, Walter

2018-03-01

Regular physical activity (PA) is beneficial for physical and psychological well-being, yet many people do not achieve these health benefits due to irregular PA participation which is also known as fluctuation. Limited attention has been given to the phenomenon of fluctuation in the PA behaviour literature. The aim of this review was to explore and to map definitions, measurements, behavioural evidence, and factors related to PA fluctuation. Eligible studies were initially identified by a systematic search of articles conducted in four databases: Scopus, PubMed, PsycINFO, and SPORTDiscus between January 1996 and March 2016. Inclusion and exclusion criteria were set to check the eligibility of all articles. Additional articles were included by manual searching and expert recommendation. Fifteen articles were finally included. Definitions of fluctuation are understood from two perspectives, either as a stage in the process of behaviour change, or as a particular PA phenomenon consisting of lapse and readoption. Common features were extracted: behavioural irregularity, high risk of drop-out, intention and readiness for PA, low automaticity, and limited self-regulation. Furthermore, fluctuation identification was summarised in three approaches such as stage algorithm, self-identified PA lapse and readoption, and prospective within-person variation in meeting the PA guidelines. Regarding the empirical evidence, this review found that people in PA fluctuation were significantly distinct from those in preparation and maintenance of PA behavioural performance, as well as distinct in psychosocial features. Notwithstanding the limitations, this review has provided valuable insight into the phenomenon of PA fluctuation.

Toward a fuzzy logic control of the infant incubator.

PubMed

Reddy, Narender P; Mathur, Garima; Hariharan, S I

2009-10-01

Premature birth is a world wide problem. Thermo regulation is a major problem in premature infants. Premature infants are often kept in infant incubators providing convective heating. Currently either the incubator air temperature is sensed and used to control the heat flow, or infant's skin temperature is sensed and used in the close loop control. Skin control often leads to large fluctuations in the incubator air temperature. Air control also leads to skin temperature fluctuations. The question remains if both the infant's skin temperature and the incubator air temperature can be simultaneously used in the control. The purpose of the present study was to address this question by developing a fuzzy logic control which incorporates both incubator air temperature and infant's skin temperature to control the heating. The control was evaluated using a lumped parameter mathematical model of infant-incubator system (Simon, B. N., N. P. Reddy, and A. Kantak, J. Biomech. Eng. 116:263-266, 1994). Simulation results confirmed previous experimental results that the on-off skin control could lead to fluctuations in the incubator air temperature, and the air control could lead to too slow rise time in the core temperature. The fuzzy logic provides a smooth control with the desired rise time.

Vegetation changes and timberline fluctuations in the Central Alps as indicators of holocene climatic oscillations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wick, L.; Tinner, W.

Pollen and plant-macrofossil data are presented for two lakes near the timberline in the Italian (Lago Basso, 2250 m) and Swiss Central Alps (Gouille Rion, 2343 m). The reforestation at both sites started at 9700-9500 BP with Pinus cembra, Larix decidua, and Betula. The timberline reached its highest elevation between 8700 and 5000 BP and retreated after 5000 BP, due to a mid-Holocene climatic change and increasing human impact since about 3500 BP (Bronze Age). The expansion of Picea abies at Lago Basso between ca. 7500 and 6200 BP was probably favored by cold phases accompanied by increased oceanicity, whereasmore » in the area of Gouille Rion, where spruce expanded rather late (between 4500 and 3500 BP), human influence equality might have been important. The mass expansion of Alnus viridis between ca. 5000 and 3500 BP probably can be related to both climatic change and human activity at timberline. During the early and middle Holocene a series of timberline fluctuations is recorded as declines in pollen and macrofossil concentrations of the major tree species, and as increases in nonarboreal pollen in the pollen percentage diagram of Gouille Rion. Most of the periods of low timberline can be correlated by radiocarbon dating the climatic changes in the Alps as indicated by glacier advances in combination with palynological records, solifluction, and dendroclimatical data. Lago Basso and Gouille Rion are the only sites in the Alps showing complete palaeobotanical records of cold phases between 10,000 and 2000 BP with very good time control. The altitudinal range of the Holocene treeline fluctuations caused by climate most likely was not more than 100 to 150 m. A possible correlation of a cold period at ca. 7500-6500 BP (Misox oscillation) in the Alps is made with paleoecological data from North American and Scandinavia and a climate signal in the GRIP ice core from central Greenland 8200 yr ago (ca. 7400 yr uncal. BP).« less

Live Soap: Stability, Order, and Fluctuations in Apolar Active Smectics

NASA Astrophysics Data System (ADS)

Adhyapak, Tapan Chandra; Ramaswamy, Sriram; Toner, John

2013-03-01

We construct a hydrodynamic theory of noisy, apolar active smectics in bulk suspension or on a substrate. Unlike purely orientationally ordered active fluids, active apolar smectics can be dynamically stable in Stokesian bulk suspensions. Smectic order in these systems is quasilong ranged in dimension d=2 and long ranged in d=3. We predict reentrant Kosterlitz-Thouless melting to an active nematic in our simplest model in d=2, a nonzero second-sound speed parallel to the layers in bulk suspensions, and that there are no giant number fluctuations in either case. We also briefly discuss possible instabilities in these systems.

Effects of Stopping Ions and LET Fluctuations on Soft Error Rate Prediction.

DOE PAGES

Weeden-Wright, S. L.; King, Michael Patrick; Hooten, N. C.; ...

2015-02-01

Variability in energy deposition from stopping ions and LET fluctuations is quantified for specific radiation environments. When compared to predictions using average LET via CREME96, LET fluctuations lead to an order-of-magnitude difference in effective flux and a nearly 4x decrease in predicted soft error rate (SER) in an example calculation performed on a commercial 65 nm SRAM. The large LET fluctuations reported here will be even greater for the smaller sensitive volumes that are characteristic of highly scaled technologies. End-of-range effects of stopping ions do not lead to significant inaccuracies in radiation environments with low solar activity unless the sensitivevolumemore » thickness is 100 μm or greater. In contrast, end-of-range effects for stopping ions lead to significant inaccuracies for sensitive- volume thicknesses less than 10 μm in radiation environments with high solar activity.« less

An experimental test of the fluctuation relation in an active camphor boat system

NASA Astrophysics Data System (ADS)

Paroor, H. M.; Nambiar, N.; Bandi, M. M.

The Gallavotti-Cohen fluctuation relation (FR) posits a specific symmetry between positive and negative fluctuations in entropy production, or a related quantity (e.g power) for systems in non-equilibrium stationary state. Successful tests in a variety of systems suggest the FR may be more generally applicable than the conditions under which it was originally derived. Systems where the FR fails are therefore valuable for the insight they provide into the FR's general success. It has recently been suggested that ``active matter'' should not satisfy the fluctuation-dissipation theorem or FR. We experimentally test this possibility in a system of active camphor boats, self-propelled by surface tension gradients at air-water interfaces. The boats interact via short-range capillary attraction which competes with long-range surface tension mediated repulsion. Tuning interaction strength with number density, we test the FR through the statistics of power as one goes from a free non-interacting camphor boat, through a few weakly interacting boats to several, strongly interacting boats. We present preliminary results of our experiments and data analysis.

Quantized vortices in the ideal bose gas: a physical realization of random polynomials.

PubMed

Castin, Yvan; Hadzibabic, Zoran; Stock, Sabine; Dalibard, Jean; Stringari, Sandro

2006-02-03

We propose a physical system allowing one to experimentally observe the distribution of the complex zeros of a random polynomial. We consider a degenerate, rotating, quasi-ideal atomic Bose gas prepared in the lowest Landau level. Thermal fluctuations provide the randomness of the bosonic field and of the locations of the vortex cores. These vortices can be mapped to zeros of random polynomials, and observed in the density profile of the gas.

Interannual variability of ring formations in the Gulf Stream region

NASA Astrophysics Data System (ADS)

Sasaki, Y. N.

2016-02-01

An oceanic ring in the Gulf Stream (GS) region plays important roles in across-jet transport of heat, salt, momentum, and nutrients. This study examines interannual variability of rings shed from the GS jet and their properties using satellite altimeter observations from 1993 to 2013. An objective method is used to capture a ring shedding from the GS jet and track its movement. A spatial distribution of the ring formations in the GS region showed that both cyclonic (cold-core) and anticyclonic (warm-core) rings were most frequently formed around the New England Seamount chain between 62°-65°W, suggesting the importance of the bottom topography on the pinch-off process. These rings moved westward, although about two-third of these rings was reabsorbed by the GS jet. The number of ring formations, especially cyclonic ring formations, indicated prominent fluctuations on interannual to decadal timescales. The annual maximum number of the pinched-off rings is four times larger than the annual minimum number of the rings. These fluctuations of the ring formations were negatively correlated with the strength of the GS. This situation is similar that in the Kuroshio Extension region. The interannual variability of the number of ring formations is also negatively correlated with the North Atlantic Oscillation (NAO) index with one-year lag (NAO leads). Interannual variations of the propagation tendency and shape of rings are also discussed.

Optical fiber sensor having an active core

NASA Technical Reports Server (NTRS)

Egalon, Claudio Oliveira (Inventor); Rogowski, Robert S. (Inventor)

1993-01-01

An optical fiber is provided. The fiber is comprised of an active fiber core which produces waves of light upon excitation. A factor ka is identified and increased until a desired improvement in power efficiency is obtained. The variable a is the radius of the active fiber core and k is defined as 2 pi/lambda wherein lambda is the wavelength of the light produced by the active fiber core. In one embodiment, the factor ka is increased until the power efficiency stabilizes. In addition to a bare fiber core embodiment, a two-stage fluorescent fiber is provided wherein an active cladding surrounds a portion of the active fiber core having an improved ka factor. The power efficiency of the embodiment is further improved by increasing a difference between the respective indices of refraction of the active cladding and the active fiber core.

A Latest Glacial and Holocene Record From Medicine Lake, Siskiyou County, California: Preliminary Diatom, Pollen, and Sediment Data

NASA Astrophysics Data System (ADS)

Starratt, S. W.; Barron, J. A.; Kneeshaw, T.; Phillips, L.; Lowenstern, J.; Wanket, J. A.

2002-12-01

Medicine Lake is a small (165 ha), relatively shallow (average 7.3 m), medium- altitude (2,036 m) lake located within the summit caldera of Medicine Lake volcano, a dormant Quaternary shield volcano located in the southern Cascade Range. During September 1999 and 2000, high-resolution bathymetry, seismic-reflection profiles, and sediment cores were collected from the lake. Twenty six samples from core B100NC-1 (water depth 12.6 m; length 226 cm) were analyzed for physical properties, sediment grain size, diatoms, pollen, and total organic carbon (TOC). Using both 14C (AMS) dating and tephrochronology, the sediments at the bottom of the core are estimated to be 11,000 cal yr B.P., thus yielding an estimated average sedimentation rate of about 21 cm/1,000 yr. The lowermost part of the core (226 cm - ~200 cm) records the transition from glacial to interglacial conditions. During the period from about 11,000-7,200 cal yr B.P., lake level fluctuated between deeper oligotrophic conditions with a diatom flora dominated by Cyclotella spp. and shallower intervals with a diverse benthic flora. The relative low abundance (10-15%) of Abies (fir) pollen and relative high abundance (30-40%) of Artemesia (sagebrush) pollen in this interval suggest drier than present-day conditions. The lowest part of this interval (226 cm - 210 cm) is almost devoid of Cyclotella and may represent an ice-covered lake in which only a small benthic flora could exist around the margins of the lake where light penetration was the greatest. The sediments in this interval are relatively low in TOC and are dominated by glacial flour. From about 7,200 cal yr B.P. to the present, conditions have fluctuated between higher lake levels (three intervals) that are dominated by Cyclotella with a reduced number and diversity of benthic taxa, and lower lake levels (two intervals) during which the abundances of Cyclotella decrease to less than 10%. Relative values of Abies and Pinus (pine) pollen are higher during high lake levels, whereas pollen of aquatic taxa (primarily Isoetes [quillwort]) increases in significance at lower lake levels. Total organic carbon is higher during high stands and lower during low stands. Comparison with recently published multi-proxy studies of the Lake Tahoe-Truckee River-Pyramid Lake drainage system suggest that some of the changes in lake level observed at Medicine Lake between about 7,500-4,500 cal yr B.P. may be regional in nature, while fluctuations over the last 4,500 yr probably reflect conditions affecting only the local watershed.

Model selection for identifying power-law scaling.

PubMed

Ton, Robert; Daffertshofer, Andreas

2016-08-01

Long-range temporal and spatial correlations have been reported in a remarkable number of studies. In particular power-law scaling in neural activity raised considerable interest. We here provide a straightforward algorithm not only to quantify power-law scaling but to test it against alternatives using (Bayesian) model comparison. Our algorithm builds on the well-established detrended fluctuation analysis (DFA). After removing trends of a signal, we determine its mean squared fluctuations in consecutive intervals. In contrast to DFA we use the values per interval to approximate the distribution of these mean squared fluctuations. This allows for estimating the corresponding log-likelihood as a function of interval size without presuming the fluctuations to be normally distributed, as is the case in conventional DFA. We demonstrate the validity and robustness of our algorithm using a variety of simulated signals, ranging from scale-free fluctuations with known Hurst exponents, via more conventional dynamical systems resembling exponentially correlated fluctuations, to a toy model of neural mass activity. We also illustrate its use for encephalographic signals. We further discuss confounding factors like the finite signal size. Our model comparison provides a proper means to identify power-law scaling including the range over which it is present. Copyright © 2016 Elsevier Inc. All rights reserved.

Interpreting the Holocene fluctuations of Quelccaya Ice Cap, Peru: using a combination of glacial and non-glacial lake records

NASA Astrophysics Data System (ADS)

Stroup, J. S.; Kelly, M. A.; Lowell, T. V.; Smith, C.; Beal, S. A., Jr.; Tapia, P. M.

2016-12-01

The past fluctuations of Quelccaya Ice Cap (QIC) are an indicator of tropical paleoclimate. At QIC, ice core and glacial geological records provide late Holocene climate constraints. However, early and middle Holocene QIC fluctuations are less well-known. To interpret past QIC fluctuations, we present Holocene-long lake sediment records from Challpacocha, a lake fed by QIC meltwater, and Yanacocha, a lake that has not received meltwater during the Holocene. To assess the clastic sediment delivered to Challpacocha by QIC meltwater, we compare visual stratigraphy, X-ray fluorescence chemistry, grainsize, loss on ignition and clastic flux records from both lakes (additional Yanacocha proxies are presented by Axford et al. (this meeting, abstract 157985)). We compare the meltwater derived clastic sediment record from Challpacocha with moraine and stratigraphic records of past ice extents during the late Holocene. This comparison indicates that clastic sediment flux in Challpacocha increased during QIC recession and decreased during QIC advance, or significantly reduced QIC extent. We then use the Challpacocha clastic sediment record to interpret early and middle Holocene QIC fluctuations. Based on the Challpacocha sediment record, combined with prior work, we suggest that from 11 to 6.5 ka QIC was similar to or smaller than its late Holocene extent. From 6.9 to 6.5 ka QIC may have been absent from the landscape. At 3-2.4 and 0.62-0.31 ka QIC experienced the most extensive Holocene fluctuations. We compare the clastic sediment fluxes from Challpacocha and Pacococha (a nearby lake fed by QIC; Rodbell et al., 2008) to infer QIC expansion between 6.5-5 ka. This is supported by 14C ages of in-situ subfossil plants which indicate ice advance at 6.3-4.7 ka (Thompson et al., 2006, 2013; Buffen et al., 2009). Our study highlights the value of using multiple datasets to improve lake sediment record interpretations.

Flow regulation manipulates contemporary seasonal sedimentary dynamics in the reservoir fluctuation zone of the Three Gorges Reservoir, China.

PubMed

Tang, Qiang; Bao, Yuhai; He, Xiubin; Fu, Bojie; Collins, Adrian L; Zhang, Xinbao

2016-04-01

Since the launch of the Three Gorges Dam on the Yangtze River, a distinctive reservoir fluctuation zone has been created and significantly modified by regular dam operations. Sediment redistribution within this artificial landscape differs substantially from that in natural fluvial riparian zones, due to a specific hydrological regime comprising steps of water impoundment with increasing magnitudes and seasonal water level fluctuation holding a range of sediment fluxes. This study reinterpreted post-dam sedimentary dynamics in the reservoir fluctuation zone by stratigraphy determination of a 345-cm long sediment core, and related it to impact of the hydrological regime. Seasonality in absolute grain-size composition of suspended sediment was applied as a methodological basis for stratigraphic differentiation. Sedimentary laminations with relatively higher proportions of sandy fractions were ascribed to sedimentation during the dry season when proximal subsurface bank erosion dominates source contributions, while stratigraphy with a lower proportion of sandy fractions is possibly contributed by sedimentation during the wet season when distal upstream surface erosion prevails. Chronology determination revealed non-linear and high annual sedimentation rates ranging from 21.7 to 152.1cm/yr. Although channel geomorphology may primarily determine the spatial extent of sedimentation, seasonal sedimentary dynamics was predominantly governed by the frequency, magnitude, and duration of flooding. Summer inundation by natural floods with enhanced sediment loads produced from upstream basins induced higher sedimentation rates than water impoundment during the dry season when distal sediment supply was limited. We thus conclude that flow regulation manipulates contemporary seasonal sedimentary dynamics in the reservoir fluctuation zone, though little impact on total sediment retention rate was detected. Ongoing reductions in flow and sediment supply under human disturbance may have profound implications in affecting sedimentary equilibrium in the reservoir fluctuation zone. The results herein provide insights of how big dams have disrupted the sediment conveyance processes of large scale fluvial systems. Copyright © 2016 Elsevier B.V. All rights reserved.

Are the Formation and Abundances of Metal-poor Stars the Result of Dust Dynamics?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, Philip F.; Conroy, Charlie, E-mail: phopkins@caltech.edu

Large dust grains can fluctuate dramatically in their local density, relative to the gas, in neutral turbulent disks. Small, high-redshift galaxies (before reionization) represent ideal environments for this process. We show via simple arguments and simulations that order-of-magnitude fluctuations are expected in local abundances of large grains (>100 Å) under these conditions. This can have important consequences for star formation and stellar metal abundances in extremely metal-poor stars. Low-mass stars can form in dust-enhanced regions almost immediately after some dust forms even if the galaxy-average metallicity is too low for fragmentation to occur. We argue that the metal abundances ofmore » these “promoted” stars may contain interesting signatures as the CNO abundances (concentrated in large carbonaceous grains and ices) and Mg and Si (in large silicate grains) can be enhanced and/or fluctuate almost independently. Remarkably, the otherwise puzzling abundance patterns of some metal-poor stars can be well fit by standard IMF-averaged core-collapse SNe yields if we allow for fluctuating local dust-to-gas ratios. We also show that the observed log-normal distribution of enhancements in pure SNe yields, shows very large enhancements and variations up to factors of ≳100 as expected in the dust-promoted model, preferentially in the [C/Fe]-enhanced metal-poor stars. Together, this suggests that (1) dust exists in second-generation star formation, (2) local dust-to-gas ratio fluctuations occur in protogalaxies and can be important for star formation, and (3) the light element abundances of these stars may be affected by the local chemistry of dust where they formed, rather than directly tracing nucleosynthesis from earlier populations.« less

Further Progress in Noise Source Identification in High Speed Jets via Causality Principle

NASA Technical Reports Server (NTRS)

Panda, J.; Seasholtz, R. G.; Elam, K. A.

2004-01-01

To locate noise sources in high-speed jets, the sound pressure fluctuations p/, measured at far field locations, were correlated with each of density p, axial velocity u, radial velocity v, puu and pvv fluctuations measured from various points in fully expanded, unheated plumes of Mach number 0.95, 1.4 and 1.8. The velocity and density fluctuations were measured simultaneously using a recently developed, non-intrusive, point measurement technique based on molecular Rayleigh scattering (Seasholtz, Panda, and Elam, AIAA Paper 2002-0827). The technique uses a continuous wave, narrow line-width laser, Fabry-Perot interferometer and photon counting electronics. The far field sound pressure fluctuations at 30 to the jet axis provided the highest correlation coefficients with all flow variables. The correlation coefficients decreased sharply with increased microphone polar angle, and beyond about 60 all correlation mostly fell below the experimental noise floor. Among all correlations < puu; p/> showed the highest values. Interestingly, , in all respects, were very similar to . The and correlations with 90deg microphone fell below the noise floor. By moving the laser probe at various locations in the jet it was found that the strongest noise source lies downstream of the end of the potential core and extends many diameters beyond. Correlation measurement from the lip shear layer showed a Mach number dependency. While significant correlations were measured in Mach 1.8 jet, values were mostly below the noise floor for subsonic Mach 0.95 jet. Various additional analyses showed that fluctuations from large organized structures mostly contributed to the measured correlation, while that from small scale structures fell below the noise floor.

Quantitative comparison of electron temperature fluctuations to nonlinear gyrokinetic simulations in C-Mod Ohmic L-mode discharges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sung, C., E-mail: csung@physics.ucla.edu; White, A. E.; Greenwald, M.

2016-04-15

Long wavelength turbulent electron temperature fluctuations (k{sub y}ρ{sub s} < 0.3) are measured in the outer core region (r/a > 0.8) of Ohmic L-mode plasmas at Alcator C-Mod [E. S. Marmar et al., Nucl. Fusion 49, 104014 (2009)] with a correlation electron cyclotron emission diagnostic. The relative amplitude and frequency spectrum of the fluctuations are compared quantitatively with nonlinear gyrokinetic simulations using the GYRO code [J. Candy and R. E. Waltz, J. Comput. Phys. 186, 545 (2003)] in two different confinement regimes: linear Ohmic confinement (LOC) regime and saturated Ohmic confinement (SOC) regime. When comparing experiment with nonlinear simulations, it is found that local,more » electrostatic ion-scale simulations (k{sub y}ρ{sub s} ≲ 1.7) performed at r/a ∼ 0.85 reproduce the experimental ion heat flux levels, electron temperature fluctuation levels, and frequency spectra within experimental error bars. In contrast, the electron heat flux is robustly under-predicted and cannot be recovered by using scans of the simulation inputs within error bars or by using global simulations. If both the ion heat flux and the measured temperature fluctuations are attributed predominantly to long-wavelength turbulence, then under-prediction of electron heat flux strongly suggests that electron scale turbulence is important for transport in C-Mod Ohmic L-mode discharges. In addition, no evidence is found from linear or nonlinear simulations for a clear transition from trapped electron mode to ion temperature gradient turbulence across the LOC/SOC transition, and also there is no evidence in these Ohmic L-mode plasmas of the “Transport Shortfall” [C. Holland et al., Phys. Plasmas 16, 052301 (2009)].« less

Density-Gradient-Driven trapped-electron-modes in improved-confinement RFP plasmas

NASA Astrophysics Data System (ADS)

Duff, James

2016-10-01

Short wavelength density fluctuations in improved-confinement MST plasmas exhibit multiple features characteristic of the trapped-electron-mode (TEM), strong evidence that drift wave turbulence emerges in RFP plasmas when transport associated with MHD tearing is reduced. Core transport in the RFP is normally governed by magnetic stochasticity stemming from long wavelength tearing modes that arise from current profile peaking. Using inductive control, the tearing modes are reduced and global confinement is increased to values expected for a comparable tokamak plasma. The improved confinement is associated with a large increase in the pressure gradient that can destabilize drift waves. The measured density fluctuations have frequencies >50 kHz, wavenumbers k_phi*rho_s<0.14, and propagate in the electron drift direction. Their spectral emergence coincides with a sharp decrease in fluctuations associated with global tearing modes. Their amplitude increases with the local density gradient, and they exhibit a density-gradient threshold at R/L_n 15, higher than in tokamak plasmas by R/a. the GENE code, modified for RFP equilibria, predicts the onset of microinstability for these strong-gradient plasma conditions. The density-gradient-driven TEM is the dominant instability in the region where the measured density fluctuations are largest, and the experimental threshold-gradient is close to the predicted critical gradient for linear stability. While nonlinear analysis shows a large Dimits shift associated with predicted strong zonal flows, the inclusion of residual magnetic fluctuations causes a collapse of the zonal flows and an increase in the predicted transport to a level close to the experimentally measured heat flux. Similar circumstances could occur in the edge region of tokamak plasmas when resonant magnetic perturbations are applied for the control of ELMs. Work supported by US DOE.

Experimental clean combustor program: Noise study

NASA Technical Reports Server (NTRS)

Sofrin, T. G.; Riloff, N., Jr.

1976-01-01

Under a Noise Addendum to the NASA Experimental Clean Combustor Program (ECCP) internal pressure fluctuations were measured during tests of JT9D combustor designs conducted in a burner test rig. Measurements were correlated with burner operating parameters using an expression relating farfield noise to these parameters. For a given combustor, variation of internal noise with operating parameters was reasonably well predicted by this expression but the levels were higher than farfield predictions and differed significantly among several combustors. For two burners, discharge stream temperature fluctuations were obtained with fast-response thermocouples to allow calculation of indirect combustion noise which would be generated by passage of the temperature inhomogeneities through the high pressure turbine stages of a JT9D turbofan engine. Using a previously developed analysis, the computed indirect combustion noise was significantly lower than total low frequency core noise observed on this and several other engines.

Faraday-effect polarimeter diagnostic for internal magnetic field fluctuation measurements in DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, J., E-mail: chenjie@ucla.edu; State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074; Ding, W. X.

2016-11-15

Motivated by the need to measure fast equilibrium temporal dynamics, non-axisymmetric structures, and core magnetic fluctuations (coherent and broadband), a three-chord Faraday-effect polarimeter-interferometer system with fast time response and high phase resolution has recently been installed on the DIII-D tokamak. A novel detection scheme utilizing two probe beams and two detectors for each chord results in reduced phase noise and increased time response [δb ∼ 1G with up to 3 MHz bandwidth]. First measurement results were obtained during the recent DIII-D experimental campaign. Simultaneous Faraday and density measurements have been successfully demonstrated and high-frequency, up to 100 kHz, Faraday-effect perturbationsmore » have been observed. Preliminary comparisons with EFIT are used to validate diagnostic performance. Principle of the diagnostic and first experimental results is presented.« less

A phase contrast imaging–interferometer system for detection of multiscale electron density fluctuations on DIII-D

DOE PAGES

Davis, E. M.; Rost, J. C.; Porkolab, M.; ...

2016-08-15

Heterodyne interferometry and phase contrast imaging (PCI) are robust, mature techniques for measuring low-k and high-k electron density fluctuations, respectively. Here, we describe the first-ever implementation of a combined PCI-interferometer. The combined system uses a single 10:6 μm probe beam, two interference schemes, and two detectors to measure electron density uctuations at large spatiotemporal bandwidth (10 kHz < f < 5MHz and 0 cm -1 ≤ k ≤ 20 cm -1), allowing simultaneous measurement of ion- and electron-scale instabilities. Further, correlating our interferometer's measurements with those from DIII-D's pre-existing, toroidally separated interferometer allows core-localized, low-n MHD studies that may otherwisemore » be inaccessible via external magnetic measurements. In the combined diagnostic's small port requirements and minimal access restrictions make it well-suited to the harsh neutron environments and limited port space expected in next-step devices.« less

Transport Studies in Alcator C-Mod ITB Plasmas

NASA Astrophysics Data System (ADS)

Fiore, C. L.; Bonoli, P. T.; Ernst, D.; Greenwald, M. J.; Ince-Cushman, A.; Lin, L.; Marmar, E. S.; Porkolab, M.; Rice, J. E.; Wukitch, S.; Rowan, W.; Bespamyatnov, I.; Phillips, P.

2008-11-01

Internal transport barriers occur in C-Mod plasmas that have off-axis ICRF heating and also in Ohmic H-mode plasmas. These ITBs are marked by highly peaked density and pressure profiles, as they rely on a reduction of particle and thermal flux in the barrier region which allows the neoclassical pinch to peak the central density without reducing the central temperature. Enhancement of several core diagnostics has resulted in increased understanding of C-Mod ITBs. Ion temperature profile measurements have been obtained using an innovative design for x-ray crystal spectrometry and clearly show a barrier forming in the ion temperature profile. The phase contrast imaging (PCI) provides limited localization of the ITB related fluctuations that increase in strength as the central density increases. Simulation of triggering conditions, integrated simulations with fluctuation measurements, parametric studies, and transport implications of fully ionized boron impurity profiles in the plasma are under study. A summary of these results will be presented.

Non-Gaussian statistics of extreme events in stimulated Raman scattering: The role of coherent memory and source noise

NASA Astrophysics Data System (ADS)

Monfared, Yashar E.; Ponomarenko, Sergey A.

2017-10-01

We explore theoretically and numerically extreme event excitation in stimulated Raman scattering in gases. We consider gas-filled hollow-core photonic crystal fibers as a particular system realization. We show that moderate amplitude pump fluctuations obeying Gaussian statistics lead to the emergence of heavy-tailed non-Gaussian statistics as coherent seed Stokes pulses are amplified on propagation along the fiber. We reveal the crucial role that coherent memory effects play in causing non-Gaussian statistics of the system. We discover that extreme events can occur even at the initial stage of stimulated Raman scattering when one can neglect energy depletion of an intense, strongly fluctuating Gaussian pump source. Our analytical results in the undepleted pump approximation explicitly illustrate power-law probability density generation as the input pump noise is transferred to the output Stokes pulses.

Modeling unsteady sound refraction by coherent structures in a high-speed jet

NASA Astrophysics Data System (ADS)

Kan, Pinqing; Lewalle, Jacques

2011-11-01

We construct a visual model for the unsteady refraction of sound waves from point sources in a Ma = 0.6 jet. The mass and inviscid momentum equations give an equation governing acoustic fluctuations, including anisotropic propagation, attenuation and sources; differences with Lighthill's equation will be discussed. On this basis, the theory of characteristics gives canonical equations for the acoustic paths from any source into the far field. We model a steady mean flow in the near-jet region including the potential core and the mixing region downstream of its collapse, and model the convection of coherent structures as traveling wave perturbations of this mean flow. For a regular distribution of point sources in this region, we present a visual rendition of fluctuating distortion, lensing and deaf spots from the viewpoint of a far-field observer. Supported in part by AFOSR Grant FA-9550-10-1-0536 and by a Syracuse University Graduate Fellowship.

Correlation of the earth's rotation rate and the secular change of the geomagnetic field. [power spectra/harmonic analysis

NASA Technical Reports Server (NTRS)

Jin, R. S.

1975-01-01

Power spectral density analysis using Burg's maximum entropy method was applied to the geomagnetic dipole field and its rate of change for the years 1901 to 1969. Both spectra indicate relative maxima at 0.015 cycles/year and its harmonics. These maxima correspond approximately to 66, 33, 22, 17, 13, 11, and 9-year spectral lines. The application of the same analysis techniques to the length-of-day (l.o.d) fluctuations for the period 1865 to 1961 reveal similar spectral characteristics. Although peaks were observed at higher harmonics of the fundamental frequency, the 22-year and 11-year lines are not attributed unambiguously to the solar magnetic cycle and the solar cycle. It is suggested that the similarity in the l.o.d fluctuations and the dipole field variations is related to the motion within the earth's fluid core during the past one hundred years.

Hepatitis C virus core protein potentiates proangiogenic activity of hepatocellular carcinoma cells.

PubMed

Shao, Yu-Yun; Hsieh, Min-Shu; Wang, Han-Yu; Li, Yong-Shi; Lin, Hang; Hsu, Hung-Wei; Huang, Chung-Yi; Hsu, Chih-Hung; Cheng, Ann-Lii

2017-10-17

Increased angiogenic activity has been demonstrated in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), but the mechanism was unclear. To study the role of HCV core protein, we used tube formation and Matrigel plug assays to assess the proangiogenic activity of an HCC cell line, HuH7, and 2 of its stable clones-HuH7-core-high and HuH7-core-low, with high and low HCV core protein expression, respectively. In both assays, HuH7-core-high and HuH7-core-low cells dose-dependently induced stronger angiogenesis than control cells. HuH7 cells with HCV core protein expression showed increased mRNA and protein expression of vascular endothelial growth factor (VEGF). VEGF inhibition by bevacizumab reduced the proangiogenic activity of HuH7-core-high cells. The promotor region of VEGF contains the binding site of activator protein-1 (AP-1). Compared with controls, HuH7-core-high cells had an increased AP-1 activity and nuclear localization of phospho-c-jun. AP-1 inhibition using either RNA knockdown or AP-1 inhibitors reduced the VEGF mRNA expression and the proangiogenic activity of HuH7-core-high cells. Among 131 tissue samples from HCC patients, HCV-related HCC revealed stronger VEGF expression than did hepatitis B virus-related HCC. In conclusion, increased VEGF expression through AP-1 activation is a crucial mechanism underlying the proangiogenic activity of the HCV core protein in HCC cells.

Hepatitis C virus core protein potentiates proangiogenic activity of hepatocellular carcinoma cells

PubMed Central

Shao, Yu-Yun; Hsieh, Min-Shu; Wang, Han-Yu; Li, Yong-Shi; Lin, Hang; Hsu, Hung-Wei; Huang, Chung-Yi; Hsu, Chih-Hung; Cheng, Ann-Lii

2017-01-01

Increased angiogenic activity has been demonstrated in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), but the mechanism was unclear. To study the role of HCV core protein, we used tube formation and Matrigel plug assays to assess the proangiogenic activity of an HCC cell line, HuH7, and 2 of its stable clones—HuH7-core-high and HuH7-core-low, with high and low HCV core protein expression, respectively. In both assays, HuH7-core-high and HuH7-core-low cells dose-dependently induced stronger angiogenesis than control cells. HuH7 cells with HCV core protein expression showed increased mRNA and protein expression of vascular endothelial growth factor (VEGF). VEGF inhibition by bevacizumab reduced the proangiogenic activity of HuH7-core-high cells. The promotor region of VEGF contains the binding site of activator protein-1 (AP-1). Compared with controls, HuH7-core-high cells had an increased AP-1 activity and nuclear localization of phospho-c-jun. AP-1 inhibition using either RNA knockdown or AP-1 inhibitors reduced the VEGF mRNA expression and the proangiogenic activity of HuH7-core-high cells. Among 131 tissue samples from HCC patients, HCV-related HCC revealed stronger VEGF expression than did hepatitis B virus-related HCC. In conclusion, increased VEGF expression through AP-1 activation is a crucial mechanism underlying the proangiogenic activity of the HCV core protein in HCC cells. PMID:29156827

Summary and interpretation of dye-tracer tests to investigate the hydraulic connection of fractures at a ridge-and-valley-wall site near Fishtrap Lake, Pike County, Kentucky

USGS Publications Warehouse

Taylor, Charles J.

1994-01-01

Dye-tracer tests were done during 1985-92 to investigate the hydraulic connection between fractures in Pennsylvanian coal-bearing strata at a ridge-and-valley-wall site near Fishtrap Lake, Pike County, Ky. Fluorescent dye was injected into a core hole penetrating near-surface and mining-induced fractures near the crest of the ridge. The rate and direction of migration of dye in the subsurface were determined by measuring the relative concentration of dye in water samples collected from piezometers completed in conductive fracture zones and fractured coal beds at various stratigraphic horizons within the ridge. Dye-concentration data and water-level measurements for each piezometer were plotted as curves on dye-recovery hydrographs. The dye-recovery hydrographs were used to evaluate trends in the fluctuation of dye concentrations and hydraulic heads in order to identify geologic and hydrologic factors affecting the subsurface transport of dye. The principal factors affecting the transport of dye in the subsurface hydrologic system were determined to be (1) the distribution, interconnection, and hydraulic properties of fractures; (2) hydraulic-head conditions in the near-fracture zone at the time of dye injection; and (3) subsequent short- and long-term fluctuations in recharge to the hydrologic system. In most of the dye-tracer tests, dye-recovery hydrographs are characterized by complex, multipeaked dye-concentration curves that are indicative of a splitting of dye flow as ground water moved through fractures. Intermittent dye pulses (distinct upward spikes in dye concentration) mark the arrivals of dye-labeled water to piezometers by way of discrete fracture-controlled flow paths that vary in length, complexity, and hydraulic conductivity. Dye injections made during relatively high- or increasinghead conditions resulted in rapid transport of dye (within several days or weeks) from near-surf ace fractures to piezometers. Injections made during relatively low- or decreasing-head conditions resulted in dye being trapped in hydraulically dead zones in water-depleted fractures. Residual dye was remobilized from storage and transported (over periods ranging from several months to about 2 years) by increased recharge to the hydrologic system. Subsequent fluctuations in hydraulic gradients, resulting from increases or decreases in recharge to the hydrologic system, acted to speed or slow the transport of dye along the fracture-controlled flow paths. The dye-tracer tests also demonstrated that mining-related disturbances significantly altered the natural fracture-controlled flow paths of the hydrologic system over time. An abandoned underground mine and subsidence-related surface cracks extend to within 250 ft of the principal dye-injection core hole. Results from two of the dye-tracer tests at the site indicate that the annular seal in the core hole was breached by subsurface propagation of the mining-induced fractures. This propagation of fractures resulted in hydraulic short-circuiting between the dye-injection zone in the core hole and two lower piezometer zones, and a partial disruption of the hydraulic connection between the injection core hole and downgradient piezometers on the ridge crest and valley wall. In addition, injected dye was detected in piezometers monitoring a flooded part of the abandoned underground mine. Dye was apparently transported into the mine through a hydraulic connection between the injection core hole and subsidence-related fractures.

Brain hyperthermia and temperature fluctuations during sexual interaction in female rats.

PubMed

Mitchum, Robert D; Kiyatkin, Eugene A

2004-03-12

Since the metabolic activity of neural cells is accompanied by heat release, brain temperature monitoring provides insight into behavior-associated changes in neural activity. In the present study, local temperatures were continuously recorded in several brain structures (nucleus accumbens, medial-preoptic hypothalamus and hippocampus) and a non-locomotor head muscle (musculus temporalis) in a receptive female rat during sexually arousing stimulation and subsequent copulatory behavior with an experienced male. Placement of the male into a neighboring compartment increased the female's temperature (approximately 0.8 degrees C) and additional, transient increases (approximately 0.2 degrees C) occurred when the rats were allowed to see and smell each other through a transparent barrier. Temperatures gradually increased further as the male repeatedly mounted and achieved intromissions, peaked 2-3 min after male's ejaculation (0.2-0.4 degrees C), and abruptly dropped until the male initiated a new copulatory cycle. Similar biphasic fluctuations accompanied subsequent copulatory cycles. Although both arousal-related temperature increases and biphasic fluctuations associated with copulatory cycles were evident in each recording location, brain sites showed consistently faster and stronger increases than the muscle, suggesting metabolic brain activation as the primary source of brain temperature fluctuations and a force behind associated changes in brain temperature. Robust brain hyperthermia and the generally similar pattern of phasic temperature fluctuations associated with individual events of sexual interaction found in males and females suggest widespread neural activation (motivational arousal) as a driving force underlying this cooperative motivated behavior in animals of both sexes. Females, however, showed different temperature changes in association with the initial (first mount or intromission) and final (ejaculation) events of each copulatory cycle, suggesting sex-specific differences in neural activity associated with the initiation and regulation of sexual behavior.

Self-consistent model of the interstellar pickup protons, Alfvenic turbulence, and core solar wind in the outer heliosphere

DOE PAGES

Gamayunov, Konstantin V.; Zhang, Ming; Pogorelov, Nikolai V.; ...

2012-09-05

In this study, a self-consistent model of the interstellar pickup protons, the slab component of the Alfvénic turbulence, and core solar wind (SW) protons is presented for r ≥ 1 along with the initial results of and comparison with the Voyager 2 (V2) observations. Two kinetic equations are used for the pickup proton distribution and Alfvénic power spectral density, and a third equation governs SW temperature including source due to the Alfvén wave energy dissipation. A fraction of the pickup proton free energy, fD , which is actually released in the waveform during isotropization, is taken from the quasi-linear considerationmore » without preexisting turbulence, whereas we use observations to specify the strength of the large-scale driving, C sh, for turbulence. The main conclusions of our study can be summarized as follows. (1) For C sh ≈ 1-1.5 and f D ≈ 0.7-1, the model slab component agrees well with the V2 observations of the total transverse magnetic fluctuations starting from ~8 AU. This indicates that the slab component at low-latitudes makes up a majority of the transverse magnetic fluctuations beyond 8-10 AU. (2) The model core SW temperature agrees well with the V2 observations for r ≳ 20 AU if f D ≈ 0.7-1. (3) A combined effect of the Wentzel-Kramers-Brillouin attenuation, large-scale driving, and pickup proton generated waves results in the energy sink in the region r ≲ 10 AU, while wave energy is pumped in the turbulence beyond 10 AU. Without energy pumping, the nonlinear energy cascade is suppressed for r ≲ 10 AU, supplying only a small energy fraction into the k-region of dissipation by the core SW protons. A similar situation takes place for the two-dimensional turbulence. (4) The energy source due to the resonant Alfvén wave damping by the core SW protons is small at heliocentric distances r ≲ 10 AU for both the slab and the two-dimensional turbulent components. As a result, adiabatic cooling mostly controls the model SW temperature in this region, and the model temperature disagrees with the V2 observations in the region r ≲ 20 AU.« less

Biological, Physical, And Chemical Data From Gulf of Mexico Core PE0305-GC1

USGS Publications Warehouse

Osterman, Lisa E.; Swarzenski, Peter W.; Hollander, David

2010-01-01

This paper presents benthic foraminiferal census data, and magnetic susceptibility, 210Pb , radiocarbon, and geochemical measurements from gravity core PE0305-GC1 (=GC1). Core GC1 was collected from the Louisiana continental shelf as part of an initiative to investigate the geographic and temporal extent of hypoxia, low-oxygen water, in the Gulf of Mexico. Hypoxia (<1.4 ml/l or <2 ppm oxygen concentration) in Gulf of Mexico waters can eventually lead to death of marine species. The development of hypoxia off the Mississippi delta has increased steadily since routine and systematic measurements were begun in 1985 and has been linked to the use of fertilizer in the Mississippi basin. Benthic foraminifers provide a proxy to track the development of hypoxia prior to 1985. Previous work determined that the relative occurrence of three low-oxygen-tolerant species is highest in the hypoxia zone. The cumulative percentage of these three species (% Pseudononion atlanticum + % Epistominella vitrea, + % Buliminella morgani = PEB index of hypoxia) was used to investigate fluctuation in paleohypoxia in four cores, including the upper 60 cm of GC1. In this report, we compile all available data from GC1 as the basis for further publications.

A continuous 250,000 yr record of oxygen and carbon isotopes in ostracode and bulk-sediment carbonate from Bear Lake, Utah-Idaho

USGS Publications Warehouse

Bright, Jordon; Kaufman, D.S.; Forester, R.M.; Dean, W.E.

2006-01-01

Oxygen and carbon isotopes from a continuous, 120-m-long, carbonate-rich core from Bear Lake, Utah-Idaho, document dramatic fluctuations in the hydrologic budget of the lake over the last 250,000 yr. Isotopic analyses of bulk sediment samples capture millennial-scale variability. Ostracode calcite was analyzed from 78 levels, mainly from the upper half of the core where valves are better preserved, to compare the isotopic value of purely endogenic carbonate with the bulk sediment, which comprises both endogenic and detrital components. The long core exhibits three relatively brief intervals with abundant endogenic aragonite (50??10%) and enriched ??18O and ??13C. These intervals are interpreted as warm/dry periods when the lake retracted into a topographically closed basin. We correlate these intervals with the interglacial periods of marine oxygen-isotope stages 1, 5e, and 7a, consistent with the presently available geochronological control. During most of the time represented by the core, the lake was fresher than the modern lake, as evidenced by depleted ??18O and ??13C in bulk-sediment carbonate. ?? 2006 Elsevier Ltd. All rights reserved.

Conformational Fluctuations in G-Protein-Coupled Receptors

NASA Astrophysics Data System (ADS)

Brown, Michael F.

2014-03-01

G-protein-coupled receptors (GPCRs) comprise almost 50% of pharmaceutical drug targets, where rhodopsin is an important prototype and occurs naturally in a lipid membrane. Rhodopsin photoactivation entails 11-cis to all-trans isomerization of the retinal cofactor, yielding an equilibrium between inactive Meta-I and active Meta-II states. Two important questions are: (1) Is rhodopsin is a simple two-state switch? Or (2) does isomerization of retinal unlock an activated conformational ensemble? For an ensemble-based activation mechanism (EAM) a role for conformational fluctuations is clearly indicated. Solid-state NMR data together with theoretical molecular dynamics (MD) simulations detect increased local mobility of retinal after light activation. Resultant changes in local dynamics of the cofactor initiate large-scale fluctuations of transmembrane helices that expose recognition sites for the signal-transducing G-protein. Time-resolved FTIR studies and electronic spectroscopy further show the conformational ensemble is strongly biased by the membrane lipid composition, as well as pH and osmotic pressure. A new flexible surface model (FSM) describes how the curvature stress field of the membrane governs the energetics of active rhodopsin, due to the spontaneous monolayer curvature of the lipids. Furthermore, influences of osmotic pressure dictate that a large number of bulk water molecules are implicated in rhodopsin activation. Around 60 bulk water molecules activate rhodopsin, which is much larger than the number of structural waters seen in X-ray crystallography, or inferred from studies of bulk hydrostatic pressure. Conformational selection and promoting vibrational motions of rhodopsin lead to activation of the G-protein (transducin). Our biophysical data give a paradigm shift in understanding GPCR activation. The new view is: dynamics and conformational fluctuations involve an ensemble of substates that activate the cognate G-protein in the amplified visual response.

Revisiting the Solar Oblateness: Is Relevant Astrophysics Possible?

NASA Astrophysics Data System (ADS)

Rozelot, J. P.; Fazel, Z.

2013-10-01

The measurement of solar oblateness has a rich history extending well back into the past. Until recently, its estimate has been actively disputed, as has its temporal dependence. Recent accurate observations of the solar shape gave cause for doubt, and so far only balloon flights or satellite experiments, such as those onboard SDO, seem to achieve the required sensitivity to measure the expected small deviations from sphericity. A shrinking or an expanding shape is ultimately linked to solar activity (likely not homologously with its change), as gravitational or magnetic fields, which are existing mechanisms for storing energy during a solar cycle, lead to distinct perturbations in the equilibrium solar-structure and changes in the diameter. It follows that a sensitive determination of the solar radius fluctuations might give information about the origin of the solar cycle. In periods of higher activity, the outer photospheric shape seems to become aspheric under the influence of higher-order multipole moments of the Sun, resulting both from the centrifugal force and the core rotation. An accurate determination of the shape of the Sun is thus one of the ways that we have now for peering into its interior, learning empirically about flows and motions there that would otherwise only be guessed at from theoretical considerations, developing more precise inferences, and ultimately building possible alternative gravitational theories.

Broken Detailed Balance of Filament Dynamics in Active Networks

NASA Astrophysics Data System (ADS)

Schmidt, Christoph F.; Gladrow, Jannes; Fakhri, Nikta; Mackintosh, Fred C.; Broedersz, Chase

Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single- walled carbon nanotubes can be used as novel tools to noninvasively track equilibrium and nonequilibrium fluctuations in biopolymer networks. We analytically calculated shape fluctuations of semi- flexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity. Transverse bending fluctuations of the probe filaments can be decomposed into dynamic normal modes. We find that these modes no longer evolve independently under non-equilibrium driving. This effective mode coupling results in nonzero circulatory currents in a conformational phase space, reflecting a violation of detailed balance. We present predictions for the characteristic frequencies associated with these currents and investigate how the temporal signatures of motor activity determine mode correlations, which we find to be consistent with recent experiments on microtubules embedded in cytoskeletal networks.

Passively stabilized 215-W monolithic CW LMA-fiber laser with innovative transversal mode filter

NASA Astrophysics Data System (ADS)

Stutzki, Fabian; Jauregui, Cesar; Voigtländer, Christian; Thomas, Jens U.; Limpert, Jens; Nolte, Stefan; Tünnermann, Andreas

2010-02-01

We report on the development of a high power monolithic CW fiber oscillator with an output power of 215 W in a 20μm core diameter few-mode Large Mode Area fiber (LMA). The key parameters for stable operation are reviewed. With these optimizations the root mean square of the output power fluctuations can be reduced to less than 0.5 % on a timescale of 20 s, which represents an improvement of more than a factor 5 over a non-optimized fiber laser. With a real-time measurement of the mode content of the fiber laser it can be shown that the few-mode nature of LMA fibers is the main factor for the residual instability of our optimized fiber laser. The root of the problem is that Fiber Bragg Gratings (FBGs) written in multimode fibers exhibit a multi-peak reflexion spectrum in which each resonance corresponds to a different transversal mode. This reflectivity spectrum stimulates multimode laser operation, which results in power and pointing instabilities due to gain competition between the different transversal modes . To stabilize the temporal and spatial behavior of the laser output, we propose an innovative passive in-fiber transversal mode filter based on modified FBG-Fabry Perot structure. This structure provides different reflectivities to the different transversal modes according to the transversal distribution of their intensity profile. Furthermore, this structure can be completely written into the active fiber using fs-laser pulses. Moreover, this concept scales very well with the fiber core diameter, which implies that there is no performance loss in fibers with even larger cores. In consequence this structure is inherently power scalable and can, therefore, be used in kW-level fiber laser systems.

Middle to Late Holocene Fluctuations of C3 and C4 Vegetation in a Northern New England Salt Marsh, Sprague Marsh, Phippsburg Maine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, B J; Moore, K A; Lehmann, C

2006-05-26

A 3.1 meter sediment core was analyzed for stable carbon isotope composition of organic matter and higher plant leaf wax (HPLW) lipid biomarkers to determine Holocene shifts in C{sub 3} (higher high marsh) and C{sub 4} (low and/or high marsh) plant deposition at the Sprague River Salt Marsh, Phippsburg, Maine. The carbon isotope composition of the bulk sediment and the HPLW parallel each other throughout most of the core, suggesting that terrestrial plants are an important source of organic matter to the sediments, and diagenetic alteration of the bulk sediments is minimal. The current salt marsh began to form 2500more » cal yr BP. Low and/or high C{sub 4} marsh plants dominated deposition at 2000 cal yr BP, 700 cal yr BP, and for the last 200 cal yr BP. Expansion of higher high marsh C{sub 3} plants occurred at 1300 and 600 cal yr BP. These major vegetation shifts result from a combination of changes in relative sea-level rise and sediment accumulation rates. Average annual carbon sequestration rates for the last 2500 years approximate 40 g C yr{sup -1} m{sup -2}, and are in strong agreement with other values published for the Gulf of Maine. Given that Maine salt marshes cover an area of {approx}79 km{sup 2}, they represent an important component of the terrestrial carbon sink. More detailed isotopic and age records from a network of sediment cores at Sprague Marsh are needed to truly evaluate the long term changes in salt marsh plant communities and the impact of more recent human activity, including global warming, on salt marsh vegetation.« less

Multiproxy records of Holocene climate and glacier variability from sediment cores in the Cordillera Vilcabamba of southern Peru

NASA Astrophysics Data System (ADS)

Schweinsberg, A. D.; Licciardi, J. M.; Rodbell, D. T.; Stansell, N.; Tapia, P. M.

2012-12-01

Sediments contained in glacier-fed lakes and bogs provide continuous high-resolution records of glacial activity, and preserve multiproxy evidence of Holocene climate change. Tropical glacier fluctuations offer critical insight on regional paleoclimatic trends and controls, however, continuous sediment records of past tropical climates are limited. Recent cosmogenic 10Be surface exposure ages of moraine sequences in the Cordillera Vilcabamba of southern Peru (13°20'S latitude) reveal a glacial culmination during the early Holocene and a less extensive glaciation coincident with the Little Ice Age of the Northern Hemisphere. Here we supplement the existing 10Be moraine chronology with the first continuous records of multiproxy climate data in this mountain range from sediment cores recovered from bogs in direct stratigraphic contact with 10Be-dated moraines. Radiocarbon-dated sedimentological changes in a 2-meter long bog core reveal that the Holocene is characterized by alternating inorganic and organic-rich laminae, suggesting high-frequency climatic variability. Carbon measurements, bulk density, and bulk sedimentation rates are used to derive a record of clastic sediment flux that serves as a proxy indicator of former glacier activity. Preliminary analyses of the bog core reveal approximately 70 diatom taxa that indicate both rheophilic and lentic environments. Initial results show a general decrease in magnetic susceptibility and clastic flux throughout the early to mid-Holocene, which suggests an interval of deglaciation. An episode of high clastic flux from 3.8 to 2.0 ka may reflect a late Holocene glacial readvance. Volcanic glass fragments and an anomalous peak in magnetic susceptibility may correspond to the historical 1600 AD eruption of Huaynaputina. Ten new bog and lake sediment cores were collected during the 2012 field expedition and analytical measurements are underway. Ongoing efforts are focused on analyzing diatom assemblage data, developing detailed records of biogenic silica, clastic sediment flux, and magnetic susceptibility, and augmenting the 10Be moraine chronology with precise limiting radiocarbon ages to provide a more comprehensive assessment of regional climate and environmental indicators. These new paleoclimatic records will fill a large geographic gap in available proxy data and contribute toward a more complete understanding of Holocene climate variability in southern Peru. In addition, the basal radiocarbon ages being developed from sediments in contact with 10Be-dated moraines will place limits on the cosmogenic 10Be production rate in the high Andes.

[Core muscle chains activation during core exercises determined by EMG-a systematic review].

PubMed

Rogan, Slavko; Riesen, Jan; Taeymans, Jan

2014-10-15

Good core muscles strength is essential for daily life and sports activities. However, the mechanism how core muscles may be effectively triggered by exercises is not yet precisely described in the literature. The aim of this systematic review was to evaluate the rate of activation as measured by electromyography of the ventral, lateral and dorsal core muscle chains during core (trunk) muscle exercises. A total of 16 studies were included. Exercises with a vertical starting position, such as the deadlift or squat activated significantly more core muscles than exercises in the horizontal initial position.

Fluctuating hydrodynamics and microrheology of a dilute suspension of swimming bacteria.

PubMed

Lau, A W C; Lubensky, T C

2009-07-01

A bacterial bath is a model active system consisting of a population of rodlike motile or self-propelled bacteria suspended in a fluid environment. This system can be viewed as an active, nonequilibrium version of a lyotropic liquid crystal or as a generalization of a driven diffusive system. We derive a set of phenomenological equations, which include the effects of internal force generators in the bacteria, describing the hydrodynamic flow, orientational dynamics of the bacteria, and fluctuations induced by both thermal and nonthermal noises. These equations violate the fluctuation dissipation theorem and the Onsager reciprocity relations. We use them to provide a quantitative account of results from recent microrheological experiments on bacterial baths.

Wind-Tunnel Experiments for Gas Dispersion in an Atmospheric Boundary Layer with Large-Scale Turbulent Motion

NASA Astrophysics Data System (ADS)

Michioka, Takenobu; Sato, Ayumu; Sada, Koichi

2011-10-01

Large-scale turbulent motions enhancing horizontal gas spread in an atmospheric boundary layer are simulated in a wind-tunnel experiment. The large-scale turbulent motions can be generated using an active grid installed at the front of the test section in the wind tunnel, when appropriate parameters for the angular deflection and the rotation speed are chosen. The power spectra of vertical velocity fluctuations are unchanged with and without the active grid because they are strongly affected by the surface. The power spectra of both streamwise and lateral velocity fluctuations with the active grid increase in the low frequency region, and are closer to the empirical relations inferred from field observations. The large-scale turbulent motions do not affect the Reynolds shear stress, but change the balance of the processes involved. The relative contributions of ejections to sweeps are suppressed by large-scale turbulent motions, indicating that the motions behave as sweep events. The lateral gas spread is enhanced by the lateral large-scale turbulent motions generated by the active grid. The large-scale motions, however, do not affect the vertical velocity fluctuations near the surface, resulting in their having a minimal effect on the vertical gas spread. The peak concentration normalized using the root-mean-squared value of concentration fluctuation is remarkably constant over most regions of the plume irrespective of the operation of the active grid.

α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study.

PubMed

Shimabukuro, Michio; Tanaka, Atsushi; Sata, Masataka; Dai, Kazuoki; Shibata, Yoshisato; Inoue, Yohei; Ikenaga, Hiroki; Kishimoto, Shinji; Ogasawara, Kozue; Takashima, Akira; Niki, Toshiyuki; Arasaki, Osamu; Oshiro, Koichi; Mori, Yutaka; Ishihara, Masaharu; Node, Koichi

2017-07-06

Little is known about clinical associations between glucose fluctuations including hypoglycemia, heart rate variability (HRV), and the activity of the sympathetic nervous system (SNS) in patients with acute phase of acute coronary syndrome (ACS). This pilot study aimed to evaluate the short-term effects of glucose fluctuations on HRV and SNS activity in type 2 diabetes mellitus (T2DM) patients with recent ACS. We also examined the effect of suppressing glucose fluctuations with miglitol on these variables. This prospective, randomized, open-label, blinded-endpoint, multicenter, parallel-group comparative study included 39 T2DM patients with recent ACS, who were randomly assigned to either a miglitol group (n = 19) or a control group (n = 20). After initial 24-h Holter electrocardiogram (ECG) (Day 1), miglitol was commenced and another 24-h Holter ECG (Day 2) was recorded. In addition, continuous glucose monitoring (CGM) was performed throughout the Holter ECG. Although frequent episodes of subclinical hypoglycemia (≤4.44 mmo/L) during CGM were observed on Day 1 in the both groups (35% of patients in the control group and 31% in the miglitol group), glucose fluctuations were decreased and the minimum glucose level was increased with substantial reduction in the episodes of subclinical hypoglycemia to 7.7% in the miglitol group on Day 2. Holter ECG showed that the mean and maximum heart rate and mean LF/HF were increased on Day 2 in the control group, and these increases were attenuated by miglitol. When divided 24-h time periods into day-time (0700-1800 h), night-time (1800-0000 h), and bed-time (0000-0700 h), we found increased SNS activity during day-time, increased maximum heart rate during night-time, and glucose fluctuations during bed-time, which were attenuated by miglitol treatment. In T2DM patients with recent ACS, glucose fluctuations with subclinical hypoglycemia were associated with alterations of HRV and SNS activity, which were mitigated by miglitol, suggesting that these pathological relationships may be a residual therapeutic target in such patients. Trial registration Unique Trial Number, UMIN000005874 ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000006929 ).

Spontaneous fluctuation of the resting membrane potential in Paramecium: amplification caused by intracellular Ca2+.

PubMed

Nakaoka, Yasuo; Imaji, Takafumi; Hara, Masahiro; Hashimoto, Noboru

2009-01-01

The ciliated protozoan Paramecium spontaneously changes its swimming direction in the absence of external stimuli. Such behavior is based on resting potential fluctuations, the amplitudes of which reach a few mV. When the resting potential fluctuation is positive and large, a spike-like depolarization is frequently elicited that reverses the beating of the cilia associated with directional changes during swimming. We aimed to study how the resting potential fluctuation is amplified. Simultaneous measurements of the resting potential and intracellular Ca(2+) ([Ca(2+)](i)) from a deciliated cell showed that positive potential fluctuations were frequently accompanied by a small increase in [Ca(2+)](i). This result suggests that Ca(2+) influx through the somatic membrane occurs during the resting state. The mean amplitude of the resting potential fluctuation was largely decreased by either an intracellular injection of a calcium chelater (BAPTA) or by an extracellular addition of Ba(2+). Hence, a small increase in [Ca(2+)](i) amplifies the resting potential fluctuation. Simulation analysis of the potential fluctuation was made by assuming that Ca(2+) and K(+) channels of surface membrane are fluctuating between open and closed states. The simulated fluctuation increased to exhibit almost the same amplitude as the measured fluctuation using the assumption that a small Ca(2+) influx activates Ca(2+) channels in a positive feedback manner.

Elastic Wave Imaging of in-Situ Bio-Alterations in a Contaminated Aquifer

NASA Astrophysics Data System (ADS)

Jaiswal, P.; Raj, R.; Atekwana, E. A.; Briand, B.; Alam, I.

2014-12-01

We present a pioneering report on the utility of seismic methods in imaging bio-induced elastic property changes within a contaminated aquifer. To understand physical properties of contaminated soil, we acquired 48 meters long multichannel seismic profile over the Norman landfill leachate plume in Norman Oklahoma, USA. We estimated both the P- and S- wave velocities respectively using full-waveform inversion of the transmission and the ground-roll coda. The resulting S-wave model showed distinct velocity anomaly (~10% over background) within the water table fluctuation zone bounded by the historical minimum and maximum groundwater table. In comparison, the P-wave velocity anomaly within the same zone was negligible. The Environmental Scanning Electron Microscope (ESEM) images of samples from a core located along the seismic profile clearly shows presence of biofilms in the water table fluctuation zone and their absence both above and below the fluctuation zone. Elemental chemistry further indicates that the sediment composition throughout the core is fairly constant. We conclude that the velocity anomaly in S-wave is due to biofilms. As a next step, we develop mechanistic modeling to gain insights into the petro-physical behavior of biofilm-bearing sediments. Preliminary results suggest that a plausible model could be biofilms acting as contact cement between sediment grains. The biofilm cement can be placed in two ways - (i) superficial non-contact deposition on sediment grains, and (ii) deposition at grain contacts. Both models explain P- and S- wave velocity structure at reasonable (~5-10%) biofilm saturation and are equivocally supported by the ESEM images. Ongoing attenuation modeling from full-waveform inversion and its mechanistic realization, may be able to further discriminate between the two cement models. Our study strongly suggests that as opposed to the traditional P-wave seismic, S-wave acquisition and imaging can be a more powerful tool for in-situ imaging of biofilm formation in field settings with significant implication for bioremediation and microbial enhanced oil recovery monitoring.

Torque balance, Taylor's constraint and torsional oscillations in a numerical model of the geodynamo

NASA Astrophysics Data System (ADS)

Dumberry, Mathieu; Bloxham, Jeremy

2003-11-01

Theoretical considerations and observations suggest that, to a first approximation, the Earth's dynamo is in a quasi-Taylor state, where the axial Lorentz torque on cylindrical surfaces co-axial with the rotation axis vanishes, except for the part involved in torsional oscillations. The latter are rigid azimuthal accelerations of cylindrical surfaces which oscillate with typical periods of decades. We present a solution of a numerical model of the geodynamo in which rigid accelerations of cylinder surfaces are observed. The underlying dynamic state in the model is not a Taylor state because the Reynolds stresses and viscous torque remain large and provide an effective way to balance a large Lorentz torque. This is a consequence of the limited parameter regime which can be attained numerically. Nevertheless, departures in the torque equilibrium are primarily counterbalanced by rigid accelerations of cylindrical surfaces, which, in turn, excite rigid azimuthal oscillations of the surfaces. We show that the azimuthal motion is indeed quasi-rigid, though the torsional oscillations that are produced in the model probably differ from those in the Earth's core because of the large influence of the Reynolds stresses on their dynamics. We also show that the continual excitation of rigid cylindrical accelerations is produced by the advection of the non-axisymmetric structure of the fields by a mean differential rotation of the cylindrical surfaces which produces disconnections and reconnections and continual fluctuations in the Lorentz torque and Reynolds stresses. We propose that the torque balance in Earth's core may evolve in a similar chaotic fashion, except that the influence of the Reynolds stresses is probably weaker. If this is the case, the Lorentz torque on a cylindrical surface is continually fluctuating, even though its time-averaged value vanishes and satisfies Taylor's constraint. Rigid accelerations of cylindrical surfaces are continually excited by the fluctuations in the Lorentz torque, and the torsional oscillations observed in the geomagnetic data are a mixture of forced and free oscillations.

Late Quaternary environmental history of Lake Valencia, Venezuela

USGS Publications Warehouse

Bradbury, J. Platt; Leyden, B.; Baker, M.R.; Lewis, W.M.; Schubert, C.; Binford, M.W.; Whitehead, D.R.; Weibezahn, F.H.

1981-01-01

Chemical, paleontological, and mineralogical analyses of a 7.5-meter core from the middle of Lake Valencia, Venezuela, have provided information on the paleoclimatic history of this low-elevation, low-latitude site for the last 13,000 years. The data show that dry climates existed in this region from 13,000 years before present (B.P.) until about 10,000 years B.P. The Lake Valencia Basin was occupied by intermittent saline marshes at that time. About 10,000 years B.P., a permanent lake of fluctuating salinity formed and arboreal plant communities replaced the earlier dominant xeric herbaceous vegetation and marsh plants. By 8500 years B.P., Lake Valencia reached moderate to low salinities and discharged water; the modern vegetation became established at that time. After 8500 years B.P., the lake twice ceased discharging as a result of reduced watershed moisture. The second of these drying episodes is still in progress and has been aggravated by human activities in the watershed.

Late quaternary environmental history of Lake Valencia, Venezuela

USGS Publications Warehouse

Platt, Bradbury J.; Leyden, B.; Salgado-Labouriau, M.; Lewis, W.M.; Schubert, C.; Binford, M.W.; Frey, D.G.; Whitehead, D.R.; Weibezahn, F.H.

1981-01-01

Chemical, paleontological, and mineralogical analyses of a 7.5-meter core from the middle of Lake Valencia, Venezuela, have provided information on the paleoclimatic history of this low-elevation, low-latitude site for the last 13,000 years. The data show that dry climates existed in this region from 13,000 years before present (B.P.) until about 10,000 years B.P. The Lake Valencia Basin was occupied by intermittent saline marshes at that time. About 10,000 years B.P., a permanent lake of fluctuating salinity formed and arboreal plant communities replaced the earlier dominant xeric herbaceous vegetation and marsh plants. By 8500 years B.P., Lake Valencia reached moderate to low salinities and discharged water; the modern vegetation became established at that time. After 8500 years B.P., the lake twice ceased discharging as a result of reduced watershed moisture. The second of these drying episodes is still in progress and has been aggravated by human activities in the watershed. Copyright ?? 1981 AAAS.

A Search for Freshwater in the Saline Aquifers of Coastal Bangladesh

NASA Astrophysics Data System (ADS)

Peters, C.; Hornberger, G. M.

2017-12-01

Can we locate pockets of freshwater amidst brackish groundwater in remote villages in Bangladesh? This study explores what we can infer about local groundwater-surface water (GW-SW) interactions in the polders of coastal Bangladesh. In this underdeveloped region, the shallow groundwater is primarily brackish with unpredictable apportioning of freshwater pockets. We use transects of piezometers, cores, electromagnetic induction, and water chemistry surveys to explore two sources of potential fresh groundwater: (1) tidal channel-aquifer exchange and (2) meteoric recharge. Freshwater is difficult to find due to disparate subsurface lithology, asymmetrical tidal dynamics, extreme seasonal fluctuations in rainfall, and limited field data. Observations suggest substantial lateral variability in shallow subsurface conductivity profiles as well as tidal pressure signals in piezometers. Nevertheless, active exchange of freshwater may be limited due to low permeability of banks and surface sediments limits. Small scale heterogeneity in delta formation likely caused much of the groundwater salinity variation. Without adequate ground truthing of groundwater quality, the ability to deduce the exact location of freshwater pockets may be restricted.

WATER AND METHANOL MASER ACTIVITIES IN THE NGC 2024 FIR 6 REGION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, Minho; Kang, Miju; Byun, Do-Young

The NGC 2024 FIR 6 region was observed in the water maser line at 22 GHz and the methanol class I maser lines at 44, 95, and 133 GHz. The water maser spectra displayed several velocity components and month-scale time variabilities. Most of the velocity components may be associated with FIR 6n, while one component was associated with FIR 4. A typical lifetime of the water maser velocity components is about eight months. The components showed velocity fluctuations with a typical drift rate of about 0.01 km s{sup -1} day{sup -1}. The methanol class I masers were detected toward FIRmore » 6. The methanol emission is confined within a narrow range around the systemic velocity of the FIR 6 cloud core. The methanol masers suggest the existence of shocks driven by either the expanding H II region of FIR 6c or the outflow of FIR 6n.« less

Dynamic relaxation of a levitated nanoparticle from a non-equilibrium steady state.

PubMed

Gieseler, Jan; Quidant, Romain; Dellago, Christoph; Novotny, Lukas

2014-05-01

Fluctuation theorems are a generalization of thermodynamics on small scales and provide the tools to characterize the fluctuations of thermodynamic quantities in non-equilibrium nanoscale systems. They are particularly important for understanding irreversibility and the second law in fundamental chemical and biological processes that are actively driven, thus operating far from thermal equilibrium. Here, we apply the framework of fluctuation theorems to investigate the important case of a system relaxing from a non-equilibrium state towards equilibrium. Using a vacuum-trapped nanoparticle, we demonstrate experimentally the validity of a fluctuation theorem for the relative entropy change occurring during relaxation from a non-equilibrium steady state. The platform established here allows non-equilibrium fluctuation theorems to be studied experimentally for arbitrary steady states and can be extended to investigate quantum fluctuation theorems as well as systems that do not obey detailed balance.

Permeability modes in fluctuating lipid membranes with DNA-translocating pores.

PubMed

Moleiro, L H; Mell, M; Bocanegra, R; López-Montero, I; Fouquet, P; Hellweg, Th; Carrascosa, J L; Monroy, F

2017-09-01

Membrane pores can significantly alter not only the permeation dynamics of biological membranes but also their elasticity. Large membrane pores able to transport macromolecular contents represent an interesting model to test theoretical predictions that assign active-like (non-equilibrium) behavior to the permeability contributions to the enhanced membrane fluctuations existing in permeable membranes [Maneville et al. Phys. Rev. Lett. 82, 4356 (1999)]. Such high-amplitude active contributions arise from the forced transport of solvent and solutes through the open pores, which becomes even dominant at large permeability. In this paper, we present a detailed experimental analysis of the active shape fluctuations that appear in highly permeable lipid vesicles with large macromolecular pores inserted in the lipid membrane, which are a consequence of transport permeability events occurred in an osmotic gradient. The experimental results are found in quantitative agreement with theory, showing a remarkable dependence with the density of membrane pores and giving account of mechanical compliances and permeability rates that are compatible with the large size of the membrane pore considered. The presence of individual permeation events has been detected in the fluctuation time-series, from which a stochastic distribution of the permeation events compatible with a shot-noise has been deduced. The non-equilibrium character of the membrane fluctuations in a permeation field, even if the membrane pores are mere passive transporters, is clearly demonstrated. Finally, a bio-nano-technology outlook of the proposed synthetic concept is given on the context of prospective uses as active membrane DNA-pores exploitable in gen-delivery applications based on lipid vesicles. Copyright © 2017 Elsevier B.V. All rights reserved.

Chromospheric variations in main-sequence stars

NASA Technical Reports Server (NTRS)

Baliunas, S. L.; Donahue, R. A.; Soon, J. H.; Horne, J. H.; Frazer, J.; Woodard-Eklund, L.; Bradford, M.; Rao, L. M.; Wilson, O. C.; Zhang, Q.

1995-01-01

The fluxes in passbands 0.1 nm wide and centered on the Ca II H and K emission cores have been monitored in 111 stars of spectral type F2-M2 on or near the main sequence in a continuation of an observing program started by O. C. Wilson. Most of the measurements began in 1966, with observations scheduled monthly until 1980, when observations were schedueld sevral times per week. The records, with a long-term precision of about 1.5%, display fluctuations that can be idntified with variations on timescales similar to the 11 yr cycle of solar activity as well as axial rotation, and the growth and decay of emitting regions. We present the records of chromospheric emission and general conclusions about variations in surface magnetic activity on timescales greater than 1 yr but less than a few decades. The results for stars of spectral type G0-K5 V indicate a pattern of change in rotation and chromospheric activity on an evolutionary timescale, in which (1) young stars exhibit high average levels of activity, rapid rotation rates, no Maunder minimum phase and rarely display a smooth, cyclic variation; (2) stars of intermediate age (approximately 1-2 Gyr for 1 solar mass) have moderate levels of activity and rotation rates, and occasional smooth cycles; and (3) stars as old as the Sun and older have slower rotation rates, lower activity levels and smooth cycles with occasional Maunder minimum-phases.

Low latitude palaeoclimate dynamics

NASA Astrophysics Data System (ADS)

Kawahata, H.; Maeda, L.

2003-04-01

Large heat storage capacity in the western equatorial Pacific (WEP) has played an important role in modulating global climate. The drying up of the huge continental platform around Indonesian Maritime continent during low sea level increased the supply rate of lithogenic matter to the ocean. Positive correlation between lithogenic content and the relative abundance of fern spores suggests that lithogenics in C4402 (3N, 135E, 4402 m water depth) could be derived from coastal lowland of New Guinea. Less rainfall during glacial times (OIS 2, 3, 4 and 4/5 boundary) generally enhanced transport of pollen by wind to Site C4402. Comparison of MAR of organic carbon (MARoc), reflecting primary production, showed big contrast between Pacific and Indian sides. Core C4402 showed high MARoc in OIS 2, 3, late 6, 6/7 boundary and 8. The record in core C2188 (4N, 141E, 2188 m water depth)located in less productive area of the WEP exhibited less fluctuation with higher values during glacial times; OIS 2, 3, 4 and late 8 except for the middle 5. The MARoc data in core O3187 (1N, 160E, 3187 m water depth) from the oligotrophic WEP displayed low values with little fluctuation. In association with the shallow thermocline, biological productivity was controlled by wind-induced surface water mixing or terrestrial inputs around Site C4402 while more intense upwelling driven by stronger winds might have made little difference to the low to medium productivity because the deeper thermocline prevented nutrient-bearing water from upwelling even during the glacial times. In contrast, MARoc in core GC5 (14S, 121E, 2472m water depth)increased gradually from OIS 6 to 3, peaked in OIS 1/2 boundary and rapidly decreased to Holocene. This profile is quite different from those obtained from the WEP. Although both sites are under influence of Asian monsoon, Site GC5 (Indian side) might have experienced continental environmental environmental change more while Site C4402 (Pacific side) remained under oceanic condition because of hundreds km from New Guinea.

Entropy Production and Fluctuation Theorems for Active Matter

NASA Astrophysics Data System (ADS)

Mandal, Dibyendu; Klymko, Katherine; DeWeese, Michael R.

2017-12-01

Active biological systems reside far from equilibrium, dissipating heat even in their steady state, thus requiring an extension of conventional equilibrium thermodynamics and statistical mechanics. In this Letter, we have extended the emerging framework of stochastic thermodynamics to active matter. In particular, for the active Ornstein-Uhlenbeck model, we have provided consistent definitions of thermodynamic quantities such as work, energy, heat, entropy, and entropy production at the level of single, stochastic trajectories and derived related fluctuation relations. We have developed a generalization of the Clausius inequality, which is valid even in the presence of the non-Hamiltonian dynamics underlying active matter systems. We have illustrated our results with explicit numerical studies.

A Critical Fast Ion Beta in the Madison Symmetric Torus Reversed Field Pinch

NASA Astrophysics Data System (ADS)

Capecchi, William J.

The first fast-ion profile measurements have been made in a reversed-field pinch (RFP) plasma. A large population of fast-ions are deposited in the core of the Madison Symmetric Torus (MST) through use of a 1 MW neutral beam injector (NBI) giving rise to a variety of beam-driven instabilities. One such mode, the energetic-particle mode (EPM) has been shown to reduce fast-ion content in MST, evident through drops in signal levels of the advanced neutral particle analyzer (ANPA). EPMs in MST appear as bursts of magnetic fluctuations at a lab frequency of ˜100 kHz reaching peak amplitude and decaying away within 100 microseconds. A burst ensemble of the neutron data does not reveal a drop in neutron emission across a burst, implying the population of fast-ions transported by a burst constitute a small fraction of the total. The burst may also pitch-angle scatter out of the ANPA phase space or be transported to mid-radius where charge-exchange with the background neutrals or fast-ion orbit stochasticity may reduce fast-ion confinement. Data gathered from the expanded neutron diagnostic suite including a new collimated neutron detector (CiNDe) was used to reconstruct the fast-ion profile in MST and measure critical fast-ion beta quantities. Measurements were made in plasma conditions with varying magnetic field strength in order to investigate the interplay between the energetic particle (EP) drive and Alfven continuum damping. The measured values of the core fast-ion beta (7.5% (1.2%) in 300 (500) kA plasmas) are reduced from classical predictions (TRANSP predicts up to 10% core value) due to EPM activity. The frequency, magnitude, and rate of occurrence of the bursts depends on the tearing mode amplitude, Alfven continuum damping rate, fast-ion profile shape, and resonant orbit dynamics. Marginal stability was reached in both moderate- (300 kA) and high- (500 kA) current discharges, marked by sustained EPM activity and a saturated global neutron signal during NBI. The difference in profile shape is interpreted to be related to the core-most resonant tearing mode amplitude, as a larger core magnetic island moves the location of steepest fast-ion gradient further out in radius, resulting in lower confinement of the fast-ions. The reconstructed profile is more strongly peaked at lower current, consistent with a lower measured core-most tearing mode amplitude. A larger dataset at lower current gives enough temporal resolution to investigate the evolution of the fast-ion profile. The suppression of the core-most tearing mode amplitude during NBI results in a rapid and dynamically evolving fast-ion profile at the beginning of the NBI discharge and results in an initially broader profile early evolving into a more strongly peaked profile later in the NBI discharge.

Structure-Based Design of Molecules to Reactivate Tumor-Derived p53 Mutations

DTIC Science & Technology

2006-06-01

fact, approximately half of the major forms of cancer contain p53 mutations, and the vast majority of these cluster in conserved regions or “hot...structures were subjected to 5.0 ns MD simulations using the program GROMACS 3.3 (Van Der Spoel et al., 2005). The RMSD values of backbone atoms from... analysis of residue-wise RMS fluctuations, shown in Figure 3B which shows that the stabilizing effect of Tris on the p53 core domain is distributed

On the ρ ∗ scaling of intrinsic rotation in C-Mod plasmas with edge transport barriers

NASA Astrophysics Data System (ADS)

Rice, J. E.; Hughes, J. W.; Diamond, P. H.; Cao, N.; Chilenski, M. A.; Hubbard, A. E.; Irby, J. H.; Kosuga, Y.; Lin, Y.; Metcalf, I. W.; Reinke, M. L.; Tolman, E. A.; Victora, M. M.; Wolfe, S. M.; Wukitch, S. J.

2017-11-01

Changes in the core intrinsic toroidal rotation velocity following L- to H- and L- to I-mode transitions have been investigated in Alcator C-Mod tokamak plasmas. The magnitude of the co-current rotation increments is found to increase with the pedestal temperature gradient and q95 , and to decrease with toroidal magnetic field. These results are captured quantitatively by a model of fluctuation entropy balance which gives the Mach number Mi \\cong ρ _*/2 L_s/LT ∼ \

Simulated shift work in rats perturbs multiscale regulation of locomotor activity

PubMed Central

Hsieh, Wan-Hsin; Escobar, Carolina; Yugay, Tatiana; Lo, Men-Tzung; Pittman-Polletta, Benjamin; Salgado-Delgado, Roberto; Scheer, Frank A. J. L.; Shea, Steven A.; Buijs, Ruud M.; Hu, Kun

2014-01-01

Motor activity possesses a multiscale regulation that is characterized by fractal activity fluctuations with similar structure across a wide range of timescales spanning minutes to hours. Fractal activity patterns are disturbed in animals after ablating the master circadian pacemaker (suprachiasmatic nucleus, SCN) and in humans with SCN dysfunction as occurs with aging and in dementia, suggesting the crucial role of the circadian system in the multiscale activity regulation. We hypothesized that the normal synchronization between behavioural cycles and the SCN-generated circadian rhythms is required for multiscale activity regulation. To test the hypothesis, we studied activity fluctuations of rats in a simulated shift work protocol that was designed to force animals to be active during the habitual resting phase of the circadian/daily cycle. We found that these animals had gradually decreased mean activity level and reduced 24-h activity rhythm amplitude, indicating disturbed circadian and behavioural cycles. Moreover, these animals had disrupted fractal activity patterns as characterized by more random activity fluctuations at multiple timescales from 4 to 12 h. Intriguingly, these activity disturbances exacerbated when the shift work schedule lasted longer and persisted even in the normal days (without forced activity) following the shift work. The disrupted circadian and fractal patterns resemble those of SCN-lesioned animals and of human patients with dementia, suggesting a detrimental impact of shift work on multiscale activity regulation. PMID:24829282

Nuclear reactor

DOEpatents

Yant, Howard W.; Stinebiser, Karl W.; Anzur, Gregory C.

1977-01-01

A nuclear reactor, particularly a liquid-metal breeder reactor, whose upper internals include outlet modules for channeling the liquid-metal coolant from selected areas of the outlet of the core vertically to the outlet plenum. The modules are composed of a highly-refractory, high corrosion-resistant alloy, for example, INCONEL-718. Each module is disposed to confine and channel generally vertically the coolant emitted from a subplurality of core-component assemblies. Each module has a grid with openings, each opening disposed to receive the coolant from an assembly of the subplurality. The grid in addition serves as a holdown for the assemblies of the corresponding subplurality preventing their excessive ejection upwardly from the core. In the region directly over the core the outlet modules are of such peripheral form that they nest forming a continuum over the core-component assemblies whose outlet coolant they confine. Each subassembly includes a chimney which confines the coolant emitted by its corresponding subassemblies to generally vertical flow between the outlet of the core and the outlet plenum. Each subplurality of assemblies whose emitted coolant is confined by an outlet module includes assemblies which emit lower-temperature coolant, for example, a control-rod assembly, or fertile assemblies, and assemblies which emit coolant of substantially higher temperature, for example, fuel-rod assemblies. The coolants of different temperatures are mixed in the chimneys reducing the effect of stripping (hot-cold temperature fluctuations) on the remainder of the upper internals which are composed typically of AISI-304 or AISI-316 stainless steel.

Development of Active Rocking Chair with Changing Swing According to Heartbeat Fluctuation

NASA Astrophysics Data System (ADS)

Kawashima, Takeshi

The purpose of this study is to realize a comfortable swing according to the condition of each individual person. A simple active rocking chair is developed, the swing of which changes with the heartbeat fluctuation of the seated person. The active rocking chair is driven by a solenoid for safety and silence. Swinging is strengthened when the period of the heartbeat lengthens, and it is weakened when the period shortens. Swinging is evaluated using a questionnaire of 16 bipolar scales that was developed for the evaluation of comfortable swinging on the basis of the semantic differential (SD) technique. As a result, it is confirmed that comfortable swinging is realized by the developed active rocking chair. Then the acceleration near the ear of the seated person is measured in order to examine the features of comfortable swinging using the feedback of heartbeat fluctuation. It is clarified that the power spectrum of the envelope of the acceleration waveform shows “1/f fluctuation”.

Chromatin hydrodynamics.

PubMed

Bruinsma, Robijn; Grosberg, Alexander Y; Rabin, Yitzhak; Zidovska, Alexandra

2014-05-06

Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-the two-fluid model-in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system is subject to both passive thermal fluctuations and active scalar and vector events that are associated with free energy consumption, such as ATP hydrolysis. Scalar events drive the longitudinal viscoelastic modes (where the chromatin fiber moves relative to the solvent) while vector events generate the transverse modes (where the chromatin fiber moves together with the solvent). Using linear response methods, we derive explicit expressions for the response functions that connect the chromatin density and velocity correlation functions to the corresponding correlation functions of the active sources and the complex viscoelastic moduli of the chromatin solution. We then derive general expressions for the flow spectral density of the chromatin velocity field. We use the theory to analyze experimental results recently obtained by one of the present authors and her co-workers. We find that the time dependence of the experimental data for both native and ATP-depleted chromatin can be well-fitted using a simple model-the Maxwell fluid-for the complex modulus, although there is some discrepancy in terms of the wavevector dependence. Thermal fluctuations of ATP-depleted cells are predominantly longitudinal. ATP-active cells exhibit intense transverse long wavelength velocity fluctuations driven by force dipoles. Fluctuations with wavenumbers larger than a few inverse microns are dominated by concentration fluctuations with the same spectrum as thermal fluctuations but with increased intensity. Copyright © 2014 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Chromatin Hydrodynamics

PubMed Central

Bruinsma, Robijn; Grosberg, Alexander Y.; Rabin, Yitzhak; Zidovska, Alexandra

2014-01-01

Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory—the two-fluid model—in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system is subject to both passive thermal fluctuations and active scalar and vector events that are associated with free energy consumption, such as ATP hydrolysis. Scalar events drive the longitudinal viscoelastic modes (where the chromatin fiber moves relative to the solvent) while vector events generate the transverse modes (where the chromatin fiber moves together with the solvent). Using linear response methods, we derive explicit expressions for the response functions that connect the chromatin density and velocity correlation functions to the corresponding correlation functions of the active sources and the complex viscoelastic moduli of the chromatin solution. We then derive general expressions for the flow spectral density of the chromatin velocity field. We use the theory to analyze experimental results recently obtained by one of the present authors and her co-workers. We find that the time dependence of the experimental data for both native and ATP-depleted chromatin can be well-fitted using a simple model—the Maxwell fluid—for the complex modulus, although there is some discrepancy in terms of the wavevector dependence. Thermal fluctuations of ATP-depleted cells are predominantly longitudinal. ATP-active cells exhibit intense transverse long wavelength velocity fluctuations driven by force dipoles. Fluctuations with wavenumbers larger than a few inverse microns are dominated by concentration fluctuations with the same spectrum as thermal fluctuations but with increased intensity. PMID:24806919

The effects of therapeutic hip exercise with abdominal core activation on recruitment of the hip muscles.

PubMed

Chan, Mandy Ky; Chow, Ka Wai; Lai, Alfred Ys; Mak, Noble Kc; Sze, Jason Ch; Tsang, Sharon Mh

2017-07-21

Core stabilization has been utilized for rehabilitation and prevention of lower limb musculoskeletal injuries. Previous studies showed that activation of the abdominal core muscles enhanced the hip muscle activity in hip extension and abduction exercises. However, the lack of the direct measurement and quantification of the activation level of the abdominal core muscles during the execution of the hip exercises affect the level of evidence to substantiate the proposed application of core exercises to promote training and rehabilitation outcome of the hip region. The aim of the present study was to examine the effects of abdominal core activation, which is monitored directly by surface electromyography (EMG), on hip muscle activation while performing different hip exercises, and to explore whether participant characteristics such as gender, physical activity level and contractile properties of muscles, which is assessed by tensiomyography (TMG), have confounding effect to the activation of hip muscles in enhanced core condition. Surface EMG of bilateral internal obliques (IO), upper gluteus maximus (UGMax), lower gluteus maximus (LGMax), gluteus medius (GMed) and biceps femoris (BF) of dominant leg was recorded in 20 young healthy subjects while performing 3 hip exercises: Clam, side-lying hip abduction (HABD), and prone hip extension (PHE) in 2 conditions: natural core activation (NC) and enhanced core activation (CO). EMG signals normalized to percentage of maximal voluntary isometric contraction (%MVIC) were compared between two core conditions with the threshold of the enhanced abdominal core condition defined as >20%MVIC of IO. Enhanced abdominal core activation has significantly promoted the activation level of GMed in all phases of clam exercise (P < 0.05), and UGMax in all phases of PHE exercise (P < 0.05), LGMax in eccentric phases of all 3 exercises (P < 0.05), and BF in all phases of all 3 exercises except the eccentric phase of PHE exercise (P < 0.05). The %MVIC of UGMax was significantly higher than that of LGMax in all phases of clam and HABD exercises under both CO and NC conditions (P < 0.001) while the %MVIC of LGMax was significantly higher than UGMax in concentric phase of PHE exercise under NC condition (P = 0.003). Gender, physical activity level and TMG parameters were not major covariates to activation of hip muscles under enhanced core condition. Abdominal core activation enhances the hip muscles recruitment in Clam, HABD and PHE exercises, and this enhancement is correlated with higher physical activity and stiffer hip muscle. Our results suggest the potential application of abdominal core activation for lower limb rehabilitation since the increased activation of target hip muscles may enhance the therapeutic effects of hip strengthening exercises.

Quantifying nonstationary radioactivity concentration fluctuations near Chernobyl: A complete statistical description

NASA Astrophysics Data System (ADS)

Viswanathan, G. M.; Buldyrev, S. V.; Garger, E. K.; Kashpur, V. A.; Lucena, L. S.; Shlyakhter, A.; Stanley, H. E.; Tschiersch, J.

2000-09-01

We analyze nonstationary 137Cs atmospheric activity concentration fluctuations measured near Chernobyl after the 1986 disaster and find three new results: (i) the histogram of fluctuations is well described by a log-normal distribution; (ii) there is a pronounced spectral component with period T=1yr, and (iii) the fluctuations are long-range correlated. These findings allow us to quantify two fundamental statistical properties of the data: the probability distribution and the correlation properties of the time series. We interpret our findings as evidence that the atmospheric radionuclide resuspension processes are tightly coupled to the surrounding ecosystems and to large time scale weather patterns.

Water turnover and core temperature on Mount Rainier.

PubMed

Hailes, Walter S; Cuddy, John S; Slivka, Dustin S; Hansen, Kent; Ruby, Brent C

2012-09-01

Hydration is an important logistical consideration for persons performing in austere environments because water demands must be balanced with the burden of carrying water. Seven novice climbers participated in a study to determine the hydration kinetics and core temperatures associated with a successful summit of Mount Rainier. Ingestible radio-equipped thermometer capsules were swallowed to monitor core temperature, and an oral dose of deuterium (0.12 ± 0.02 g·kg⁻¹ body weight) was administered to determine hydration kinetics. Mean core temperature throughout the 5.5-hour climb to Camp Muir (3000 m) was 37.6 ± 0.3°C. Water turnover was 95.0 ± 17.5 mL·kg⁻¹·24 h⁻¹ over the duration of the 43-hour study. There was a trend for reduced body mass from before (75.9 ± 13.0 kg) to after (74.8 ± 12.5 kg) the climb (P = .06), and urine specific gravity increased from before (1.013 ± 0.002) to after (1.022 ± 0.006) the climb (P = .004). Hydration demands of climbing Mount Rainier are highly elevated despite modest fluctuations in core temperature. Participants experienced hypohydration but were able to maintain sufficient hydration to successfully summit Mount Rainier and return home safely. Copyright © 2012 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Core-satellite populations and seasonality of water meter biofilms in a metropolitan drinking water distribution system

PubMed Central

Ling, Fangqiong; Hwang, Chiachi; LeChevallier, Mark W; Andersen, Gary L; Liu, Wen-Tso

2016-01-01

Drinking water distribution systems (DWDSs) harbor the microorganisms in biofilms and suspended communities, yet the diversity and spatiotemporal distribution have been studied mainly in the suspended communities. This study examined the diversity of biofilms in an urban DWDS, its relationship with suspended communities and its dynamics. The studied DWDS in Urbana, Illinois received conventionally treated and disinfected water sourced from the groundwater. Over a 2-year span, biomass were sampled from household water meters (n=213) and tap water (n=20) to represent biofilm and suspended communities, respectively. A positive correlation between operational taxonomic unit (OTU) abundance and occupancy was observed. Examined under a ‘core-satellite' model, the biofilm community comprised 31 core populations that encompassed 76.7% of total 16 S rRNA gene pyrosequences. The biofilm communities shared with the suspended community highly abundant and prevalent OTUs, which related to methano-/methylotrophs (i.e., Methylophilaceae and Methylococcaceae) and aerobic heterotrophs (Sphingomonadaceae and Comamonadaceae), yet differed by specific core populations and lower diversity and evenness. Multivariate tests indicated seasonality as the main contributor to community structure variation. This pattern was resilient to annual change and correlated to the cyclic fluctuations of core populations. The findings of a distinctive biofilm community assemblage and methano-/methyltrophic primary production provide critical insights for developing more targeted water quality monitoring programs and treatment strategies for groundwater-sourced drinking water systems. PMID:26251872

Core-satellite populations and seasonality of water meter biofilms in a metropolitan drinking water distribution system.

PubMed

Ling, Fangqiong; Hwang, Chiachi; LeChevallier, Mark W; Andersen, Gary L; Liu, Wen-Tso

2016-03-01

Drinking water distribution systems (DWDSs) harbor the microorganisms in biofilms and suspended communities, yet the diversity and spatiotemporal distribution have been studied mainly in the suspended communities. This study examined the diversity of biofilms in an urban DWDS, its relationship with suspended communities and its dynamics. The studied DWDS in Urbana, Illinois received conventionally treated and disinfected water sourced from the groundwater. Over a 2-year span, biomass were sampled from household water meters (n=213) and tap water (n=20) to represent biofilm and suspended communities, respectively. A positive correlation between operational taxonomic unit (OTU) abundance and occupancy was observed. Examined under a 'core-satellite' model, the biofilm community comprised 31 core populations that encompassed 76.7% of total 16 S rRNA gene pyrosequences. The biofilm communities shared with the suspended community highly abundant and prevalent OTUs, which related to methano-/methylotrophs (i.e., Methylophilaceae and Methylococcaceae) and aerobic heterotrophs (Sphingomonadaceae and Comamonadaceae), yet differed by specific core populations and lower diversity and evenness. Multivariate tests indicated seasonality as the main contributor to community structure variation. This pattern was resilient to annual change and correlated to the cyclic fluctuations of core populations. The findings of a distinctive biofilm community assemblage and methano-/methyltrophic primary production provide critical insights for developing more targeted water quality monitoring programs and treatment strategies for groundwater-sourced drinking water systems.

Short-term fluctuations in motivation to quit smoking in a sample of smokers in Hawaii.

PubMed

Herzog, Thaddeus; Pokhrel, Pallav; Kawamoto, Crissy T

2015-01-01

Despite its potential for usefulness in informing the development of smoking cessation interventions, short-term fluctuations in motivation to quit is a relatively understudied topic. To assess the prevalence of smokers' day-to-day fluctuations in motivation to quit, and to assess associations of day-to-day fluctuations in motivation to quit with several established cessation-related variables. A cross-sectional survey was administered to smokers in Hawaii (N = 1,567). To assess short-term fluctuations in motivation to quit smoking, participants were asked to respond "True" or "False" to the statement: "My motivation to quit smoking changes from one day to the next." Other items measured desire to quit smoking, intention to quit, confidence in quitting, cigarette dependence, and other cessation-related variables. "My motivation to quit smoking changes from one day to the next" was endorsed as true by 64.7% of smokers, and false by 35.3%. Analyses revealed that smokers who indicated fluctuating motivation were significantly more interested in quitting as compared to smokers without fluctuations. Fluctuations in motivation to quit also were associated with greater confidence in quitting, lesser cigarette dependence, and more recent quitting activity (all p < .01). Day-to-day fluctuations in motivation to quit are common. Day-to-day fluctuations in motivation to quit are strongly associated with higher motivation to quit, greater confidence in future quitting, and other positive cessation-relevant trends.

Development of TEC fluctuations in northern and southern hemispheres on the base of GPS observations

NASA Astrophysics Data System (ADS)

Shagimuratov, Irk; Krankowski, Andrzej; Sieradzki, Rafal; Ephishov, I. I.

GPS technique is widely used to study the global structure and dynamics of the ionosphere. In this paper GPS observations carried out at Arctic and Antarctic stations belonging to the IGS network were used to study TEC fluctuations in the high-latitude ionosphere during the ionospheric storms. Dual-frequency GPS phase measurements along individual satellite passes served as raw data. It was shown that ionospheric irregularities of a different scale were devel-oped in the auroral and polar ionosphere. It is a common phenomenon caused phase fluctuations of GPS signals. In November 2009, West Department of IZMIRAN in Kaliningrad (Russia) and University of Warmia and Mazury in Olsztyn (Poland) established computer server for automatic monitoring of these irregularities. The rate of TEC index (ROTI) expressed in TECU/min was used as a measure of TEC fluctuations. During its operation TEC variations related to ionospheric structures of a spatial scale more than 200-300 km were detected. Large-scale ionospheric structures cause an increase in horizontal gradients and difficulties with the carrier phase ambiguity resolution in GPS positioning. In turn, the phase fluctuations can cause cycle-slip effects. At the polar stations, ionospheric structures with TEC enhanced by a factor of 3-5 relative to the background were detected, whereas TEC increased to 5-8 TECU in about 10-15 min. These structures were observed during a storm, as well as during a moderate geomagnetic activity. It can be probably attributed to the polar cap patches. In this study are presented the extended and more detailed analyses of TEC fluctuations in both the northern and southern hemispheres and compare the winter and summer events (November and July 2004 storms). A special attention is given to the features related to TEC fluctuations occur-rence in both hemispheres for conjugated GPS stations. The temporal development of both storms was rather similar. During storms the intensity of irregularities essentially increases and its location expands to equator. Maximal activity of TEC fluctuations took place when IMF Bz component was negative. Storm-time development of TEC fluctuations caused by ionospheric irregularities was controlled by UT. At polar stations TEC fluctuations were more expressed at southern (winter) hemisphere. Over auroral stations the difference of TEC fluctuations oc-currence was less expressed. During storm the strong TEC fluctuations can be registered at subauroral ionosphere (on latitudes lower than 55 CGL). The seasonal effect in this area also took place. Differences and similarities of these storms occurrence of TEC fluctuations with dependence on season are discussed.

Conformational Changes in a Hyperthermostable Glycoside Hydrolase: Enzymatic Activity Is a Consequence of the Loop Dynamics and Protonation Balance

PubMed Central

de Oliveira, Leandro C.; da Silva, Viviam M.; Colussi, Francieli; Cabral, Aline D.; de Oliveira Neto, Mario; Squina, Fabio M.; Garcia, Wanius

2015-01-01

Endo-β-1, 4-mannanase from Thermotoga petrophila (TpMan) is a modular hyperthermostable enzyme involved in the degradation of mannan-containing polysaccharides. The degradation of these polysaccharides represents a key step for several industrial applications. Here, as part of a continuing investigation of TpMan, the region corresponding to the GH5 domain (TpManGH5) was characterized as a function of pH and temperature. The results indicated that the enzymatic activity of the TpManGH5 is pH-dependent, with its optimum activity occurring at pH 6. At pH 8, the studies demonstrated that TpManGH5 is a molecule with a nearly spherical tightly packed core displaying negligible flexibility in solution, and with size and shape very similar to crystal structure. However, TpManGH5 experiences an increase in radius of gyration in acidic conditions suggesting expansion of the molecule. Furthermore, at acidic pH values, TpManGH5 showed a less globular shape, probably due to a loop region slightly more expanded and flexible in solution (residues Y88 to A105). In addition, molecular dynamics simulations indicated that conformational changes caused by pH variation did not change the core of the TpManGH5, which means that only the above mentioned loop region presents high degree of fluctuations. The results also suggested that conformational changes of the loop region may facilitate polysaccharide and enzyme interaction. Finally, at pH 6 the results indicated that TpManGH5 is slightly more flexible at 65°C when compared to the same enzyme at 20°C. The biophysical characterization presented here is well correlated with the enzymatic activity and provide new insight into the structural basis for the temperature and pH-dependent activity of the TpManGH5. Also, the data suggest a loop region that provides a starting point for a rational design of biotechnological desired features. PMID:25723179

Dynamic Brain Network Correlates of Spontaneous Fluctuations in Attention.

PubMed

Kucyi, Aaron; Hove, Michael J; Esterman, Michael; Hutchison, R Matthew; Valera, Eve M

2017-03-01

Human attention is intrinsically dynamic, with focus continuously shifting between elements of the external world and internal, self-generated thoughts. Communication within and between large-scale brain networks also fluctuates spontaneously from moment to moment. However, the behavioral relevance of dynamic functional connectivity and possible link with attentional state shifts is unknown. We used a unique approach to examine whether brain network dynamics reflect spontaneous fluctuations in moment-to-moment behavioral variability, a sensitive marker of attentional state. Nineteen healthy adults were instructed to tap their finger every 600 ms while undergoing fMRI. This novel, but simple, approach allowed us to isolate moment-to-moment fluctuations in behavioral variability related to attention, independent of common confounds in cognitive tasks (e.g., stimulus changes, response inhibition). Spontaneously increasing tap variance ("out-of-the-zone" attention) was associated with increasing activation in dorsal-attention and salience network regions, whereas decreasing tap variance ("in-the-zone" attention) was marked by increasing activation of default mode network (DMN) regions. Independent of activation, tap variance representing out-of-the-zone attention was also time-locked to connectivity both within DMN and between DMN and salience network regions. These results provide novel mechanistic data on the understudied neural dynamics of everyday, moment-to-moment attentional fluctuations, elucidating the behavioral importance of spontaneous, transient coupling within and between attention-relevant networks. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Conformational changes accompany activation of reovirus RNA-dependent RNA transcription

PubMed Central

Mendez, Israel I.; Weiner, Scott G.; She, Yi-Min; Yeager, Mark; Coombs, Kevin M.

2009-01-01

Many critical biologic processes involve dynamic interactions between proteins and nucleic acids. Such dynamic processes are often difficult to delineate by conventional static methods. For example, while a variety of nucleic acid polymerase structures have been determined at atomic resolution, the details of how some multi-protein transcriptase complexes actively produce mRNA, as well as conformational changes associated with activation of such complexes, remain poorly understood. The mammalian reovirus innermost capsid (core) manifests all enzymatic activities necessary to produce mRNA from each of the 10 encased double-stranded RNA genes. We used rapid freezing and electron cryo-microscopy to trap and visualize transcriptionally active reovirus core particles and compared them to inactive core images. Rod-like density centered within actively transcribing core spike channels was attributed to exiting nascent mRNA. Comparative radial density plots of active and inactive core particles identified several structural changes in both internal and external regions of the icosahedral core capsid. Inactive and transcriptionally active cores were partially digested with trypsin and identities of initial tryptic peptides determined by mass spectrometry. Differentially-digested peptides, which also suggest transcription-associated conformational changes, were placed within the known 3-dimensional structures of major core proteins. PMID:18321727

Understanding the core-halo relation of quantum wave dark matter from 3D simulations.

PubMed

Schive, Hsi-Yu; Liao, Ming-Hsuan; Woo, Tak-Pong; Wong, Shing-Kwong; Chiueh, Tzihong; Broadhurst, Tom; Hwang, W-Y Pauchy

2014-12-31

We examine the nonlinear structure of gravitationally collapsed objects that form in our simulations of wavelike cold dark matter, described by the Schrödinger-Poisson (SP) equation with a particle mass ∼10(-22)  eV. A distinct gravitationally self-bound solitonic core is found at the center of every halo, with a profile quite different from cores modeled in the warm or self-interacting dark matter scenarios. Furthermore, we show that each solitonic core is surrounded by an extended halo composed of large fluctuating dark matter granules which modulate the halo density on a scale comparable to the diameter of the solitonic core. The scaling symmetry of the SP equation and the uncertainty principle tightly relate the core mass to the halo specific energy, which, in the context of cosmological structure formation, leads to a simple scaling between core mass (Mc) and halo mass (Mh), Mc∝a(-1/2)Mh(1/3), where a is the cosmic scale factor. We verify this scaling relation by (i) examining the internal structure of a statistical sample of virialized halos that form in our 3D cosmological simulations and by (ii) merging multiple solitons to create individual virialized objects. Sufficient simulation resolution is achieved by adaptive mesh refinement and graphic processing units acceleration. From this scaling relation, present dwarf satellite galaxies are predicted to have kiloparsec-sized cores and a minimum mass of ∼10(8)M⊙, capable of solving the small-scale controversies in the cold dark matter model. Moreover, galaxies of 2×10(12)M⊙ at z=8 should have massive solitonic cores of ∼2×10(9)M⊙ within ∼60  pc. Such cores can provide a favorable local environment for funneling the gas that leads to the prompt formation of early stellar spheroids and quasars.

32 CFR 169a.9 - Reviews: Existing in-house commercial activities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... skill levels. (ii) Core logistics activities. The core logistics capability reported to Congress, March... either government or contractor personnel, whichever is more cost effective. Core logistics activities... submitted to the ASD (P&L). DoD Components may propose to the ASD (P&L) additional core logistics capability...

Measurement of magnetic field fluctuations and diamagnetic currents within a laser ablation plasma interacting with an axial magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ikeda, S.; Horioka, K.; Okamura, M.

Here, the guiding of laser ablation plasmas with axial magnetic fields has been used for many applications, since its effectiveness has been proven empirically. For more sophisticated and complicated manipulations of the plasma flow, the behavior of the magnetic field during the interaction and the induced diamagnetic current in the plasma plume needs to be clearly understood. To achieve the first milestone for establishing magnetic plasma manipulation, we measured the spatial and temporal fluctuations of the magnetic field caused by the diamagnetic current. We showed that the small fluctuations of the magnetic field can be detected by using a simplemore » magnetic probe. We observed that the field penetrates to the core of the plasma plume. The diamagnetic current estimated from the magnetic field had temporal and spatial distributions which were confirmed to be correlated with the transformation of the plasma plume. Our results show that the measurement by the magnetic probe is an effective method to observe the temporal and spatial distributions of the magnetic field and diamagnetic current. The systematic measurement of the magnetic field variations is a valuable method to establish the magnetic field manipulation of the laser ablation plasma.« less

Multi-scale transport in the DIII-D ITER baseline scenario with direct electron heating and projection to ITER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grierson, B. A.; Staebler, G. M.; Solomon, W. M.

Multi-scale fluctuations measured by turbulence diagnostics spanning long and short wavelength spatial scales impact energy confinement and the scale-lengths of plasma kinetic profiles in the DIII-D ITER baseline scenario with direct electron heating. Contrasting discharge phases with ECH + neutral beam injection (NBI) and NBI only at similar rotation reveal higher energy confinement and lower fluctuations when only NBI heating is used. Modeling of the core transport with TGYRO using the TGLF turbulent transport model and NEO neoclassical transport reproduces the experimental profile changes upon application of direct electron heating and indicates that multi-scale transport mechanisms are responsible for changesmore » in the temperature and density profiles. Intermediate and high-k fluctuations appear responsible for the enhanced electron thermal flux, and intermediate-k electron modes produce an inward particle pinch that increases the inverse density scale length. Projection to ITER is performed with TGLF and indicates a density profile that has a finite scale length due to intermediate-k electron modes at low collisionality and increases the fusion gain. Finally, for a range of E×B shear, the dominant mechanism that increases fusion performance is suppression of outward low-k particle flux and increased density peaking.« less

Multi-scale transport in the DIII-D ITER baseline scenario with direct electron heating and projection to ITER

DOE PAGES

Grierson, B. A.; Staebler, G. M.; Solomon, W. M.; ...

2018-02-01

Multi-scale fluctuations measured by turbulence diagnostics spanning long and short wavelength spatial scales impact energy confinement and the scale-lengths of plasma kinetic profiles in the DIII-D ITER baseline scenario with direct electron heating. Contrasting discharge phases with ECH + neutral beam injection (NBI) and NBI only at similar rotation reveal higher energy confinement and lower fluctuations when only NBI heating is used. Modeling of the core transport with TGYRO using the TGLF turbulent transport model and NEO neoclassical transport reproduces the experimental profile changes upon application of direct electron heating and indicates that multi-scale transport mechanisms are responsible for changesmore » in the temperature and density profiles. Intermediate and high-k fluctuations appear responsible for the enhanced electron thermal flux, and intermediate-k electron modes produce an inward particle pinch that increases the inverse density scale length. Projection to ITER is performed with TGLF and indicates a density profile that has a finite scale length due to intermediate-k electron modes at low collisionality and increases the fusion gain. Finally, for a range of E×B shear, the dominant mechanism that increases fusion performance is suppression of outward low-k particle flux and increased density peaking.« less

Measurement of magnetic field fluctuations and diamagnetic currents within a laser ablation plasma interacting with an axial magnetic field

DOE PAGES

Ikeda, S.; Horioka, K.; Okamura, M.

2017-10-10

Here, the guiding of laser ablation plasmas with axial magnetic fields has been used for many applications, since its effectiveness has been proven empirically. For more sophisticated and complicated manipulations of the plasma flow, the behavior of the magnetic field during the interaction and the induced diamagnetic current in the plasma plume needs to be clearly understood. To achieve the first milestone for establishing magnetic plasma manipulation, we measured the spatial and temporal fluctuations of the magnetic field caused by the diamagnetic current. We showed that the small fluctuations of the magnetic field can be detected by using a simplemore » magnetic probe. We observed that the field penetrates to the core of the plasma plume. The diamagnetic current estimated from the magnetic field had temporal and spatial distributions which were confirmed to be correlated with the transformation of the plasma plume. Our results show that the measurement by the magnetic probe is an effective method to observe the temporal and spatial distributions of the magnetic field and diamagnetic current. The systematic measurement of the magnetic field variations is a valuable method to establish the magnetic field manipulation of the laser ablation plasma.« less

Multi-scale transport in the DIII-D ITER baseline scenario with direct electron heating and projection to ITER

NASA Astrophysics Data System (ADS)

Grierson, B. A.; Staebler, G. M.; Solomon, W. M.; McKee, G. R.; Holland, C.; Austin, M.; Marinoni, A.; Schmitz, L.; Pinsker, R. I.; DIII-D Team

2018-02-01

Multi-scale fluctuations measured by turbulence diagnostics spanning long and short wavelength spatial scales impact energy confinement and the scale-lengths of plasma kinetic profiles in the DIII-D ITER baseline scenario with direct electron heating. Contrasting discharge phases with ECH + neutral beam injection (NBI) and NBI only at similar rotation reveal higher energy confinement and lower fluctuations when only NBI heating is used. Modeling of the core transport with TGYRO using the TGLF turbulent transport model and NEO neoclassical transport reproduces the experimental profile changes upon application of direct electron heating and indicates that multi-scale transport mechanisms are responsible for changes in the temperature and density profiles. Intermediate and high-k fluctuations appear responsible for the enhanced electron thermal flux, and intermediate-k electron modes produce an inward particle pinch that increases the inverse density scale length. Projection to ITER is performed with TGLF and indicates a density profile that has a finite scale length due to intermediate-k electron modes at low collisionality and increases the fusion gain. For a range of E × B shear, the dominant mechanism that increases fusion performance is suppression of outward low-k particle flux and increased density peaking.

The impact of teachers’ modifications of an evidenced-based HIV prevention intervention on program outcomes

PubMed Central

Wang, Bo; Stanton, Bonita; Lunn, Sonja; Rolle, Glenda; Poitier, Maxwell; Adderley, Richard; Li, Xiaoming; Koci, Veronica; Deveaux, Lynette

2015-01-01

The degree to which evidence-based program outcomes are affected by modifications is a significant concern in the implementation of interventions. The ongoing national implementation of an evidence-based HIV prevention program targeting grade six students in The Bahamas [Focus on Youth in The Caribbean (FOYC)] offers an opportunity to explore factors associated with teachers’ modification of FOYC lessons and to examine the impact of types and degrees of modifications on student outcomes. Data were collected in 2012 from 155 teachers and 3646 students in 77 government elementary schools. Results indicate that teachers taught 16 of 30 core activities, 24.5 of 46 total activities and 4.7 of 8 sessions. Over one-half of the teachers made modifications to FOYC core activities; one-fourth of the teachers modified 25% or more core activities that they taught (heavily modified FOYC). Omitting core activities was the most common content modification, followed by lengthening FOYC lessons with reading, writing assignments or role-play games, shortening core activities or adding educational videos. Mixed-effects modeling revealed that omitting core activities had negative impacts on all four student outcomes. Shortening core activities and adding videos into lessons had negative impacts on HIV/AIDS knowledge and/or intention to use condom protection. Heavy modifications (>1/4 core activities) were associated with diminished program effectiveness. Heavy modifications and omitting or shortening core activities were negatively related to teachers’ level of implementation. We conclude that poorer student outcomes were associated with heavy modifications. PMID:26297497

The Impact of Teachers' Modifications of an Evidenced-Based HIV Prevention Intervention on Program Outcomes.

PubMed

Wang, Bo; Stanton, Bonita; Lunn, Sonja; Rolle, Glenda; Poitier, Maxwell; Adderley, Richard; Li, Xiaoming; Koci, Veronica; Deveaux, Lynette

2016-01-01

The degree to which evidence-based program outcomes are affected by modifications is a significant concern in the implementation of interventions. The ongoing national implementation of an evidence-based HIV prevention program targeting grade 6 students in The Bahamas [Focus on Youth in The Caribbean (FOYC)] offers an opportunity to explore factors associated with teachers' modification of FOYC lessons and to examine the impact of types and degrees of modifications on student outcomes. Data were collected in 2012 from 155 teachers and 3646 students in 77 government elementary schools. Results indicate that teachers taught 16 of 30 core activities, 24.5 of 46 total activities and 4.7 of 8 sessions. Over one-half of the teachers made modifications to FOYC core activities; one-fourth of the teachers modified 25 % or more core activities that they taught (heavily modified FOYC). Omitting core activities was the most common content modification, followed by lengthening FOYC lessons with reading, writing assignments or role-play games, and shortening core activities or adding educational videos. Mixed-effects modeling revealed that omitting core activities had negative impacts on all four student outcomes. Shortening core activities and adding videos into lessons had negative impacts on HIV/AIDS knowledge and/or intention to use condom protection. Heavy modifications (>1/4 core activities) were associated with diminished program effectiveness. Heavy modifications and omitting or shortening core activities were negatively related to teachers' level of implementation. We conclude that poorer student outcomes were associated with heavy modifications.

The effects of baryon physics, black holes and active galactic nucleus feedback on the mass distribution in clusters of galaxies

NASA Astrophysics Data System (ADS)

Martizzi, Davide; Teyssier, Romain; Moore, Ben; Wentz, Tina

2012-06-01

The spatial distribution of matter in clusters of galaxies is mainly determined by the dominant dark matter component; however, physical processes involving baryonic matter are able to modify it significantly. We analyse a set of 500 pc resolution cosmological simulations of a cluster of galaxies with mass comparable to Virgo, performed with the AMR code RAMSES. We compare the mass density profiles of the dark, stellar and gaseous matter components of the cluster that result from different assumptions for the subgrid baryonic physics and galaxy formation processes. First, the prediction of a gravity-only N-body simulation is compared to that of a hydrodynamical simulation with standard galaxy formation recipes, and then all results are compared to a hydrodynamical simulation which includes thermal active galactic nucleus (AGN) feedback from supermassive black holes (SMBHs). We find the usual effects of overcooling and adiabatic contraction in the run with standard galaxy formation physics, but very different results are found when implementing SMBHs and AGN feedback. Star formation is strongly quenched, producing lower stellar densities throughout the cluster, and much less cold gas is available for star formation at low redshifts. At redshift z= 0 we find a flat density core of radius 10 kpc in both the dark and stellar matter density profiles. We speculate on the possible formation mechanisms able to produce such cores and we conclude that they can be produced through the coupling of different processes: (I) dynamical friction from the decay of black hole orbits during galaxy mergers; (II) AGN-driven gas outflows producing fluctuations of the gravitational potential causing the removal of collisionless matter from the central region of the cluster; (III) adiabatic expansion in response to the slow expulsion of gas from the central region of the cluster during the quiescent mode of AGN activity.

Immotile Active Matter: Activity from Death and Reproduction

NASA Astrophysics Data System (ADS)

Kalziqi, Arben; Yanni, David; Thomas, Jacob; Ng, Siu Lung; Vivek, Skanda; Hammer, Brian K.; Yunker, Peter J.

2018-01-01

Unlike equilibrium atomic solids, biofilms—soft solids composed of bacterial cells—do not experience significant thermal fluctuations at the constituent level. However, living cells stochastically reproduce and die, provoking a mechanical response. We investigate the mechanical consequences of cellular death and reproduction by measuring surface-height fluctuations of biofilms containing two mutually antagonistic strains of Vibrio cholerae that kill one another on contact via the type VI secretion system. While studies of active matter typically focus on activity via constituent mobility, here, activity is mediated by reproduction and death events in otherwise immobilized cells. Biofilm surface topography is measured in the nearly homeostatic limit via white light interferometry. Although biofilms are far from equilibrium systems, measured surface-height fluctuation spectra resemble the spectra of thermal permeable membranes but with an activity-mediated effective temperature, as predicted by Risler, Peilloux, and Prost [Phys. Rev. Lett. 115, 258104 (2015), 10.1103/PhysRevLett.115.258104]. By comparing the activity of killer strains of V. cholerae with that of genetically modified strains that cannot kill each other and validating with individual-based simulations, we demonstrate that extracted effective temperatures increase with the amount of death and reproduction and that death and reproduction can fluidize biofilms. Together, these observations demonstrate the unique physical consequences of activity mediated by death and reproduction events.

Immotile Active Matter: Activity from Death and Reproduction.

PubMed

Kalziqi, Arben; Yanni, David; Thomas, Jacob; Ng, Siu Lung; Vivek, Skanda; Hammer, Brian K; Yunker, Peter J

2018-01-05

Unlike equilibrium atomic solids, biofilms-soft solids composed of bacterial cells-do not experience significant thermal fluctuations at the constituent level. However, living cells stochastically reproduce and die, provoking a mechanical response. We investigate the mechanical consequences of cellular death and reproduction by measuring surface-height fluctuations of biofilms containing two mutually antagonistic strains of Vibrio cholerae that kill one another on contact via the type VI secretion system. While studies of active matter typically focus on activity via constituent mobility, here, activity is mediated by reproduction and death events in otherwise immobilized cells. Biofilm surface topography is measured in the nearly homeostatic limit via white light interferometry. Although biofilms are far from equilibrium systems, measured surface-height fluctuation spectra resemble the spectra of thermal permeable membranes but with an activity-mediated effective temperature, as predicted by Risler, Peilloux, and Prost [Phys. Rev. Lett. 115, 258104 (2015)PRLTAO0031-900710.1103/PhysRevLett.115.258104]. By comparing the activity of killer strains of V. cholerae with that of genetically modified strains that cannot kill each other and validating with individual-based simulations, we demonstrate that extracted effective temperatures increase with the amount of death and reproduction and that death and reproduction can fluidize biofilms. Together, these observations demonstrate the unique physical consequences of activity mediated by death and reproduction events.

FLARE-LIKE VARIABILITY OF THE Mg II {lambda}2800 EMISSION LINE IN THE {gamma}-RAY BLAZAR 3C 454.3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leon-Tavares, J.; Chavushyan, V.; Patino-Alvarez, V.

2013-02-01

We report the detection of a statistically significant flare-like event in the Mg II {lambda}2800 emission line of 3C 454.3 during the outburst of autumn 2010. The highest levels of emission line flux recorded over the monitoring period (2008-2011) coincide with a superluminal jet component traversing through the radio core. This finding crucially links the broad emission line fluctuations to the non-thermal continuum emission produced by relativistically moving material in the jet and hence to the presence of broad-line region clouds surrounding the radio core. If the radio core were located at several parsecs from the central black hole, thenmore » our results would suggest the presence of broad-line region material outside the inner parsec where the canonical broad-line region is envisaged to be located. We briefly discuss the implications of broad emission line material ionized by non-thermal continuum in the context of virial black hole mass estimates and gamma-ray production mechanisms.« less

Shearing of the CENP-A dimerization interface mediates plasticity in the octameric centromeric nucleosome

PubMed Central

Winogradoff, David; Zhao, Haiqing; Dalal, Yamini; Papoian, Garegin A.

2015-01-01

The centromeric nucleosome is a key epigenetic determinant of centromere identity and function. Consequently, deciphering how CENP-A containing nucleosomes contribute structurally to centromere function is a fundamental question in chromosome biology. Here, we performed microsecond timescale all-atom molecular dynamics (MD) simulations of CENP-A and H3 nucleosomes, and report that the octameric CENP-A core particles and nucleosomes display different dynamics from their canonical H3-containing counterparts. The most significant motion observed is within key interactions at the heart of the CENP-A octameric core, wherein shearing of contacts within the CENP-A:CENP-A’ dimerization interface results in a weaker four helix bundle, and an extrusion of 10–30 bp of DNA near the pseudo-dyad. Coupled to other local and global fluctuations, the CENP-A nucleosome occupies a more rugged free energy landscape than the canonical H3 nucleosome. Taken together, our data suggest that CENP-A encodes enhanced distortability to the octameric nucleosome, which may allow for enhanced flexing of the histone core in vivo. PMID:26602160

Heterogeneous firing responses predict diverse couplings to presynaptic activity in mice layer V pyramidal neurons

PubMed Central

2017-01-01

In this study, we present a theoretical framework combining experimental characterizations and analytical calculus to capture the firing rate input-output properties of single neurons in the fluctuation-driven regime. Our framework consists of a two-step procedure to treat independently how the dendritic input translates into somatic fluctuation variables, and how the latter determine action potential firing. We use this framework to investigate the functional impact of the heterogeneity in firing responses found experimentally in young mice layer V pyramidal cells. We first design and calibrate in vitro a simplified morphological model of layer V pyramidal neurons with a dendritic tree following Rall's branching rule. Then, we propose an analytical derivation for the membrane potential fluctuations at the soma as a function of the properties of the synaptic input in dendrites. This mathematical description allows us to easily emulate various forms of synaptic input: either balanced, unbalanced, synchronized, purely proximal or purely distal synaptic activity. We find that those different forms of dendritic input activity lead to various impact on the somatic membrane potential fluctuations properties, thus raising the possibility that individual neurons will differentially couple to specific forms of activity as a result of their different firing response. We indeed found such a heterogeneous coupling between synaptic input and firing response for all types of presynaptic activity. This heterogeneity can be explained by different levels of cellular excitability in the case of the balanced, unbalanced, synchronized and purely distal activity. A notable exception appears for proximal dendritic inputs: increasing the input level can either promote firing response in some cells, or suppress it in some other cells whatever their individual excitability. This behavior can be explained by different sensitivities to the speed of the fluctuations, which was previously associated to different levels of sodium channel inactivation and density. Because local network connectivity rather targets proximal dendrites, our results suggest that this aspect of biophysical heterogeneity might be relevant to neocortical processing by controlling how individual neurons couple to local network activity. PMID:28410418

Simulated shift work in rats perturbs multiscale regulation of locomotor activity.

PubMed

Hsieh, Wan-Hsin; Escobar, Carolina; Yugay, Tatiana; Lo, Men-Tzung; Pittman-Polletta, Benjamin; Salgado-Delgado, Roberto; Scheer, Frank A J L; Shea, Steven A; Buijs, Ruud M; Hu, Kun

2014-07-06

Motor activity possesses a multiscale regulation that is characterized by fractal activity fluctuations with similar structure across a wide range of timescales spanning minutes to hours. Fractal activity patterns are disturbed in animals after ablating the master circadian pacemaker (suprachiasmatic nucleus, SCN) and in humans with SCN dysfunction as occurs with aging and in dementia, suggesting the crucial role of the circadian system in the multiscale activity regulation. We hypothesized that the normal synchronization between behavioural cycles and the SCN-generated circadian rhythms is required for multiscale activity regulation. To test the hypothesis, we studied activity fluctuations of rats in a simulated shift work protocol that was designed to force animals to be active during the habitual resting phase of the circadian/daily cycle. We found that these animals had gradually decreased mean activity level and reduced 24-h activity rhythm amplitude, indicating disturbed circadian and behavioural cycles. Moreover, these animals had disrupted fractal activity patterns as characterized by more random activity fluctuations at multiple timescales from 4 to 12 h. Intriguingly, these activity disturbances exacerbated when the shift work schedule lasted longer and persisted even in the normal days (without forced activity) following the shift work. The disrupted circadian and fractal patterns resemble those of SCN-lesioned animals and of human patients with dementia, suggesting a detrimental impact of shift work on multiscale activity regulation. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Molecular Dynamics of a Water-Lipid Bilayer Interface

NASA Technical Reports Server (NTRS)

Wilson, Michael A.; Pohorille, Andrew

1994-01-01

We present results of molecular dynamics simulations of a glycerol 1-monooleate bilayer in water. The total length of analyzed trajectories is 5ns. The calculated width of the bilayer agrees well with the experimentally measured value. The interior of the membrane is in a highly disordered fluid state. Atomic density profile, orientational and conformational distribution functions, and order parameters indicate that disorder increases toward the center of the bilayer. Analysis of out-of-plane thermal fluctuations of the bilayer surfaces occurring at the time scale of the present calculations reveals that the distribution of modes agrees with predictions of the capillary wave model. Fluctuations of both bilayer surfaces are uncorrelated, yielding Gaussian distribution of instantaneous widths of the membrane. Fluctuations of the width produce transient thinning defects in the bilayer which occasionally span almost half of the membrane. The leading mechanism of these fluctuations is the orientational and conformational motion of head groups rather than vertical motion of the whole molecules. Water considerably penetrates the head group region of the bilayer but not its hydrocarbon core. The total net excess dipole moment of the interfacial water points toward the aqueous phase, but the water polarization profile is non-monotonic. Both water and head groups significantly contribute to the surface potential across the interface. The calculated sign of the surface potential is in agreement with that from experimental measurements, but the value is markedly overestimated. The structural and electrical properties of the water-bilayer system are discussed in relation to membrane functions, in particular transport of ions and nonelectrolytes across membranes.

The Effects of Ovarian Hormones and Emotional Eating on Changes in Weight Preoccupation Across the Menstrual Cycle

PubMed Central

Hildebrandt, Britny A.; Racine, Sarah E.; Keel, Pamela K.; Burt, S. Alexandra; Neale, Michael; Boker, Steven; Sisk, Cheryl L.; Klump, Kelly L.

2014-01-01

Objective Previous research has shown that fluctuations in ovarian hormones (i.e., estradiol and progesterone) predict changes in binge eating and emotional eating across the menstrual cycle. However, the extent to which other eating disorder symptoms fluctuate across the menstrual cycle and are influenced by ovarian hormones remains largely unknown. The current study sought to examine whether levels of weight preoccupation vary across the menstrual cycle and whether changes in ovarian hormones and/or other factors (i.e., emotional eating, negative affect) account for menstrual-cycle fluctuations in this eating disorder phenotype. Method For 45 consecutive days, 352 women ages 15–25 provided daily ratings of weight preoccupation, negative affect, and emotional eating. Daily saliva samples also were collected and assayed for estradiol and progesterone levels using enzyme-immunoassay techniques. Results Weight preoccupation varied significantly across the menstrual cycle, with the highest levels in the pre-menstrual and menstrual phases. However, ovarian hormones did not account for within-person changes in weight preoccupation across the menstrual cycle. Instead, the most significant predictor of menstrual-cycle changes in weight preoccupation was changes in emotional eating. Discussion Fluctuations in weight preoccupation across the menstrual cycle appear to be influenced primarily by emotional eating rather than ovarian hormones. Future research should continue to examine relationships among ovarian hormones, weight preoccupation, emotional eating, and other core eating disorder symptoms (e.g., body dissatisfaction, compensatory behaviors) in an effort to more fully understand the role of these biological and behavioral factors for the full spectrum of eating pathology. PMID:24965609

Optimizing performance by improving core stability and core strength.

PubMed

Hibbs, Angela E; Thompson, Kevin G; French, Duncan; Wrigley, Allan; Spears, Iain

2008-01-01

Core stability and core strength have been subject to research since the early 1980s. Research has highlighted benefits of training these processes for people with back pain and for carrying out everyday activities. However, less research has been performed on the benefits of core training for elite athletes and how this training should be carried out to optimize sporting performance. Many elite athletes undertake core stability and core strength training as part of their training programme, despite contradictory findings and conclusions as to their efficacy. This is mainly due to the lack of a gold standard method for measuring core stability and strength when performing everyday tasks and sporting movements. A further confounding factor is that because of the differing demands on the core musculature during everyday activities (low load, slow movements) and sporting activities (high load, resisted, dynamic movements), research performed in the rehabilitation sector cannot be applied to the sporting environment and, subsequently, data regarding core training programmes and their effectiveness on sporting performance are lacking. There are many articles in the literature that promote core training programmes and exercises for performance enhancement without providing a strong scientific rationale of their effectiveness, especially in the sporting sector. In the rehabilitation sector, improvements in lower back injuries have been reported by improving core stability. Few studies have observed any performance enhancement in sporting activities despite observing improvements in core stability and core strength following a core training programme. A clearer understanding of the roles that specific muscles have during core stability and core strength exercises would enable more functional training programmes to be implemented, which may result in a more effective transfer of these skills to actual sporting activities.

Description of core samples returned by Apollo 12

NASA Technical Reports Server (NTRS)

Lindsay, J. F.; Fryxell, R.

1971-01-01

Three core samples were collected by the Apollo 12 astronauts. Two are single cores, one of which (sample 12026) was collected close to the lunar module during the first extravehicular activity period and is 19.3 centimeters long. The second core (sample 12027) was collected at Sharp Crater during the second extravehicular activity period and is 17.4 centimeters long. The third sample is a double core (samples 12025 and 12028), which was collected near Halo Crater during the second extravehicular activity period. Unlike the other cores, the double-drive-tube core sample has complex layering with at least 10 clearly defined stratigraphic units. This core sample is approximately 41 centimeters long.

Ni@Ru and NiCo@Ru Core-Shell Hexagonal Nanosandwiches with a Compositionally Tunable Core and a Regioselectively Grown Shell.

PubMed

Hwang, Hyeyoun; Kwon, Taehyun; Kim, Ho Young; Park, Jongsik; Oh, Aram; Kim, Byeongyoon; Baik, Hionsuck; Joo, Sang Hoon; Lee, Kwangyeol

2018-01-01

The development of highly active electrocatalysts is crucial for the advancement of renewable energy conversion devices. The design of core-shell nanoparticle catalysts represents a promising approach to boost catalytic activity as well as save the use of expensive precious metals. Here, a simple, one-step synthetic route is reported to prepare hexagonal nanosandwich-shaped Ni@Ru core-shell nanoparticles (Ni@Ru HNS), in which Ru shell layers are overgrown in a regioselective manner on the top and bottom, and around the center section of a hexagonal Ni nanoplate core. Notably, the synthesis can be extended to NiCo@Ru core-shell nanoparticles with tunable core compositions (Ni 3 Co x @Ru HNS). Core-shell HNS structures show superior electrocatalytic activity for the oxygen evolution reaction (OER) to a commercial RuO 2 black catalyst, with their OER activity being dependent on their core compositions. The observed trend in OER activity is correlated to the population of Ru oxide (Ru 4+ ) species, which can be modulated by the core compositions. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Preparation and biological activities of anti-HER2 monoclonal antibodies with fully core-fucosylated homogeneous bi-antennary complex-type glycans.

PubMed

Tsukimura, Wataru; Kurogochi, Masaki; Mori, Masako; Osumi, Kenji; Matsuda, Akio; Takegawa, Kaoru; Furukawa, Kiyoshi; Shirai, Takashi

2017-12-01

Recently, the absence of a core-fucose residue in the N-glycan has been implicated to be important for enhancing antibody-dependent cellular cytotoxicity (ADCC) activity of immunoglobulin G monoclonal antibodies (mAbs). Here, we first prepared anti-HER2 mAbs having two core-fucosylated N-glycan chains with the single G2F, G1aF, G1bF, or G0F structure, together with those having two N-glycan chains with a single non-core-fucosylated corresponding structure for comparison, and determined their biological activities. Dissociation constants of mAbs with core-fucosylated N-glycans bound to recombinant Fcγ-receptor type IIIa variant were 10 times higher than those with the non-core-fucosylated N-glycans, regardless of core glycan structures. mAbs with the core-fucosylated N-glycans had markedly reduced ADCC activities, while those with the non-core-fucosylated N-glycans had high activities. These results indicate that the presence of a core-fucose residue in the N-glycan suppresses the binding to the Fc-receptor and the induction of ADCC of anti-HER2 mAbs.

HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPAR{gamma}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Kook Hwan; Hong, Sung Pyo; Kim, KyeongJin

2007-04-20

Hepatic steatosis is a common feature in patients with chronic hepatitis C virus (HCV) infection. HCV core protein plays an important role in the development of hepatic steatosis in HCV infection. Because SREBP1 (sterol regulatory element binding protein 1) and PPAR{gamma} (peroxisome proliferators-activated receptor {gamma}) are involved in the regulation of lipid metabolism of hepatocyte, we sought to determine whether HCV core protein may impair the expression and activity of SREBP1 and PPAR{gamma}. In this study, it was demonstrated that HCV core protein increases the gene expression of SREBP1 not only in Chang liver, Huh7, and HepG2 cells transiently transfectedmore » with HCV core protein expression plasmid, but also in Chang liver-core stable cells. Furthermore, HCV core protein enhanced the transcriptional activity of SREBP1. In addition, HCV core protein elevated PPAR{gamma} transcriptional activity. However, HCV core protein had no effect on PPAR{gamma} gene expression. Finally, we showed that HCV core protein stimulates the genes expression of lipogenic enzyme and fatty acid uptake associated protein. Therefore, our finding provides a new insight into the mechanism of hepatic steatosis by HCV infection.« less

Dendrochronology and lakes: using tree-rings of alder to reconstruct lake levels

NASA Astrophysics Data System (ADS)

van der Maaten, Ernst; Buras, Allan; Scharnweber, Tobias; Simard, Sonia; Kaiser, Knut; Lorenz, Sebastian; van der Maaten-Theunissen, Marieke; Wilmking, Martin

2014-05-01

Climate change is considered a major threat for ecosystems around the world. Assessing its effects is challenging, amongst others, as we are unsure how ecosystems may respond to climate conditions they were not exposed to before. However, increased insight may be obtained by analyzing responses of ecosystems to past climate variability. In this respect, lake ecosystems appear as valuable sentinels, because they provide direct and indirect indicators of change through effects of climate. Lake-level fluctuations of closed catchments, for example, reflect a dynamic water balance, provide detailed insight in past moisture variations, and thereby allow for assessments of effects of anticipated climate change. Up to now, lake-level data are mostly obtained from gauging records and reconstructions from sediments and landforms. However, these records are in many cases only available over relatively short time periods, and, since geoscientific work is highly demanding, lake-level reconstructions are lacking for many regions. Here, we present and discuss an alternative method to reconstruct lake levels, which is based on tree-ring data of black alder (Alnus glutinosa L.). This tree species tolerates permanently waterlogged and temporally flooded conditions (i.e. riparian vegetation), and is often found along lakeshores. As the yearly growth of trees varies depending upon the experienced environmental conditions, annual rings of black alder from lakeshore vegetation likely capture information on variations in water table, and may therefore be used to reconstruct lake levels. Although alder is a relatively short-lived tree species, the frequent use of its' decay-resistant wood in foundations of historical buildings offers the possibility of extending living tree-chronologies back in time for several centuries. In this study, the potential to reconstruct lake-level fluctuations from tree-ring chronologies of black alder is explored for three lake ecosystems in the Mecklenburg Lake District, northeastern Germany. Tree-ring data were collected from black alder forests surrounding the lakes 'Tiefer See', 'Drewitzer See' and 'Großer Fürstenseer See'. At all research sites, increment cores were extracted from at least 15 trees (2 cores per tree) using an increment borer. In the tree-ring lab DendroGreif, these cores were prepared and annual tree-ring widths were measured. Thereafter, site-specific tree-ring chronologies were built using established detrending and standardization procedures. Preliminary results show that the growth of alder reacts upon water level fluctuations. We visually and statistically compare the developed tree-ring chronologies with historical lake-level records, and retrospectively model lake levels. Findings will be presented while critically reflecting upon the quality of these reconstructions.

Quasithermodynamic Contributions to the Fluctuations of a Protein Nanopore

PubMed Central

2015-01-01

Proteins undergo thermally activated conformational fluctuations among two or more substates, but a quantitative inquiry on their kinetics is persistently challenged by numerous factors, including the complexity and dynamics of various interactions, along with the inability to detect functional substates within a resolvable time scale. Here, we analyzed in detail the current fluctuations of a monomeric β-barrel protein nanopore of known high-resolution X-ray crystal structure. We demonstrated that targeted perturbations of the protein nanopore system, in the form of loop-deletion mutagenesis, accompanying alterations of electrostatic interactions between long extracellular loops, produced modest changes of the differential activation free energies calculated at 25 °C, ΔΔG⧧, in the range near the thermal energy but substantial and correlated modifications of the differential activation enthalpies, ΔΔH⧧, and entropies, ΔΔS⧧. This finding indicates that the local conformational reorganizations of the packing and flexibility of the fluctuating loops lining the central constriction of this protein nanopore were supplemented by changes in the single-channel kinetics. These changes were reflected in the enthalpy–entropy reconversions of the interactions between the loop partners with a compensating temperature, TC, of ∼300 K, and an activation free energy constant of ∼41 kJ/mol. We also determined that temperature has a much greater effect on the energetics of the equilibrium gating fluctuations of a protein nanopore than other environmental parameters, such as the ionic strength of the aqueous phase as well as the applied transmembrane potential, likely due to ample changes in the solvation activation enthalpies. There is no fundamental limitation for applying this approach to other complex, multistate membrane protein systems. Therefore, this methodology has major implications in the area of membrane protein design and dynamics, primarily by revealing a better quantitative assessment on the equilibrium transitions among multiple well-defined and functionally distinct substates of protein channels and pores. PMID:25479108

Implications of Late Pliocene-Pleistocene Humidity Fluctuations in the Qaidam Paleolake (NE Tibetan Plateau) Deduced from Magnetic Susceptibility Measurements

NASA Astrophysics Data System (ADS)

Herb, C.; Appel, E.; Koutsodendris, A.; Zhang, W.; Pross, J.; Fang, X.

2014-12-01

The Qaidam Basin (NE Tibetan Plateau) contains a near-continuous, up to 12 km thick sequence of Cenozoic strata that offers a unique opportunity for studying long-term climate change. We investigate the 940-m-long drill core SG-1 from the western Qaidam Basin, which is characterized by a long-term transition from a semi-deep freshwater lake to nearly complete exsiccation of the water body, detected by several studies including geochemical and lithological observations. Based on magnetostratigraphy and optically stimulated luminescence dating, and refined by orbital tuning, the SG-1 core spans the interval from 2.69 to 0.1 Ma. Moisture availability in the western Qaidam Basin deduced from the pollen ratio Artemisia/Chenopodiaceae (A/C), suggests desert to steppe vegetation along core SG-1 as a long-term feature. Magnetic susceptibility (χ) is well suited for the high-resolution investigation of paleohumidity. The meaning of χ as a paleohydrology proxy is shown by comparing χ to other magnetic proxies for checking its relation to magnetic grain sizes and magnetic mineralogy as well as to pollen results. χ variations are analyzed to obtain regional information on the factors leading to the drying process of the Qaidam paleolake as well as potential driving factors for humidity fluctuations (e.g., insolation). An important topic that needs further investigation is the influence of monsoon in the Qaidam Basin. While the southern part of the Tibetan Plateau is directly affected by monsoon precipitation through the topographic barrier, its influence in the past is questionable in the hyper-arid Qaidam Basin. We check a potential coupling to the monsoon system in the western Qaidam Basin by comparing our χ record to reconstructions of the Asian monsoon system from other archives as well as searching evidence from orbital cyclicities found in the χ time series.

Greenhouse to Icehouse Antarctic Paleoclimate and Ice History from George V Land and Adélie Land Shelf Sediments

NASA Astrophysics Data System (ADS)

Williams, T.; Escutia, C.; De Santis, L.; O'Brien, P.; Pekar, S. F.; Brinkhuis, H.; Domack, E. W.

2013-12-01

Along the George V and Adélie Land continental shelf of East Antarctica, shallowly-buried strata contain a record of Antarctica's climate and ice history from the lush forests of the Eocene greenhouse to the dynamic ice sheet margins of the Neogene. Short piston cores and dredges have recovered Early Cretaceous and Eocene organic-rich sediment at the seabed, and in 2010, IODP Expedition 318 recovered earliest Oligocene and early Pliocene subglacial and proglacial diamictites. However, challenging ice and drilling conditions from the JOIDES Resolution on the shelf resulted in poor core recovery and sites had to be abandoned before the stratigraphic targets could be reached. Therefore, in a new IODP drilling proposal submitted earlier this year, we propose to use the MeBo sea bed drill for improved core recovery and easier access to the shelf, and drill a stratigraphic transect of shallow (~80m) holes. To investigate the evolution of the Antarctic ice sheet in this sector, we target strata above and below regional erosional and downlap surfaces to date and characterize major episodes of ice sheet advance and retreat. These direct records of ice extent on the shelf can be set in the context of Southern Ocean records of temperature, ice-rafted debris (IRD) and latitudinal fluctuations of the opal belt, and hence we can relate ice sheet evolution to paleoclimate conditions. Targets include possible late Eocene precursor glaciations, the Eocene/Oligocene boundary erosion surface, Oligocene and Miocene ice extents, and ice margin fluctuations in the Pliocene. At the Cretaceous and Eocene proposed sites, marine and terrestrial temperature proxies and palynological records will provide information on high-latitude paleoenvironments and pole-equator temperature gradients. Here we present existing data from the area and the proposed new drill sites. The ice and climate history of the George V and Adélie Land margin can provide warm-world scenarios to help understand ice sheet instability in analogous future warm climates.

Holocene lake level changes at a lowland lake in northeastern Germany inferred from acoustic sub-bottom profiling and a transect of sediment cores

NASA Astrophysics Data System (ADS)

Dietze, Elisabeth; Zawiska, Izabela; Słowiński, Michał; Brauer, Achim

2015-04-01

Holocene lake level changes were studied at Lake Fürstenseer See, a typical lake with complex basin morphology in northeastern German sandur area. An acoustic sub-bottom profile and a transect of four long sediment cores in the deepest lake sub-basin were analyzed. The cores were dated with AMS-14C and correlated with multiple proxies (sediment facies, μ-XRF, macrofossils, subfossil Cladocera, carbonate isotopes). At sites in 10 and 15 m water depth, shifts in the sand-mud boundary, i.e. sediment limit sensu Digerfeldt (1986), allowed quantitative estimates of the absolute amplitude of lake level changes. At sites in 20 and 23 m water depth, the negative correlation of Ca and Ti reflect lake level changes qualitatively. During high lake stands massive organic muds were deposited. Lower lake levels isolated the lake sub-basins which reduced the overall water circulation and lead to the deposition of Ti-poor carbonate muds. Furthermore, macrofossil and subfossil Cladocera analyses were used as proxies for the intense reworking at the slope and for the trophic state of the lake, respectively. Lake levels were up to 4 m higher, e.g. around 5000 cal. yrs BP and during the Medieval time period (see also Kaiser et al., 2014). During the early to mid-Holocene (between 9400 and 6400 cal. yrs BP), Lake Fürstenseer See fluctuated at an at least 3-m lower level. Further water level changes can be related to known climatic events and regional human impact. Digerfeldt, G., 1986. Studies on past lake-level fluctuations. In Berglund, B. (ed.), Handbook of Holocene Palaeoecology and Palaeohydrology: 127-144. John Wiley & Sons, New York. Kaiser, K., Küster, M., Fülling, A., Theuerkauf, M., Dietze, E., Graventein, H., Koch, P.J., Bens, O., Brauer, A., 2014. Littoral landforms and pedosedimentary sequences indicating late Holocene lake-level changes in northern central Europe ' A case study from northeastern Germany. Geomorphology 216, 58-78.

G-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics Simulation

PubMed Central

Ichikawa, Osamu; Fujimoto, Kazushi; Yamada, Atsushi; Okazaki, Susumu; Yamazaki, Kazuto

2016-01-01

The efficacy and bias of signal transduction induced by a drug at a target protein are closely associated with the benefits and side effects of the drug. In particular, partial agonist activity and G-protein/β-arrestin-biased agonist activity for the G-protein-coupled receptor (GPCR) family, the family with the most target proteins of launched drugs, are key issues in drug discovery. However, designing GPCR drugs with appropriate efficacy and bias is challenging because the dynamic mechanism of signal transduction induced by ligand—receptor interactions is complicated. Here, we identified the G-protein/β-arrestin-linked fluctuating network, which initiates large-scale conformational changes, using sub-microsecond molecular dynamics (MD) simulations of the β2-adrenergic receptor (β2AR) with a diverse collection of ligands and correlation analysis of their G protein/β-arrestin efficacy. The G-protein-linked fluctuating network extends from the ligand-binding site to the G-protein-binding site through the connector region, and the β-arrestin-linked fluctuating network consists of the NPxxY motif and adjacent regions. We confirmed that the averaged values of fluctuation in the fluctuating network detected are good quantitative indexes for explaining G protein/β-arrestin efficacy. These results indicate that short-term MD simulation is a practical method to predict the efficacy and bias of any compound for GPCRs. PMID:27187591

Effect of the specimen length on ultrasonic P-wave velocity in some volcanic rocks and limestones

NASA Astrophysics Data System (ADS)

Karaman, Kadir; Kaya, Ayberk; Kesimal, Ayhan

2015-12-01

Ultrasonic P-wave velocity (UPV) is commonly used in different fields such as civil, mining, geotechnical, and rock engineering. One of the significant parameters which affect the UPV of rock materials is likely to be the length of test cores although it is not mentioned in the literature. In this study, in order to explore the influence of the specimen length on the UPV, rock samples were collected from eight different locations in Turkey. The NX-sized core specimens having different length of 50, 75, 100, 125, and 150 mm were prepared. Before the analyses, rocks were divided into two groups in terms of their geological origins such as volcanic and chemical sedimentary (limestone) rocks. The UPV tests were carried out under dry and saturated conditions for each 200 core specimens. By evaluating the test results, it was shown that the length of the specimens significantly affects the UPV values. Based on the regression analyses, a method was developed to determine the threshold specimen length of studied rocks. Fluctuations in UPVdry and UPVsat values were generally observed for cores smaller than the threshold specimen length. In this study, the threshold specimen length was determined as 79 mm for volcanic rocks and 109 mm for limestones.

A deep dynamo generating Mercury's magnetic field.

PubMed

Christensen, Ulrich R

2006-12-21

Mercury has a global magnetic field of internal origin and it is thought that a dynamo operating in the fluid part of Mercury's large iron core is the most probable cause. However, the low intensity of Mercury's magnetic field--about 1% the strength of the Earth's field--cannot be reconciled with an Earth-like dynamo. With the common assumption that Coriolis and Lorentz forces balance in planetary dynamos, a field thirty times stronger is expected. Here I present a numerical model of a dynamo driven by thermo-compositional convection associated with inner core solidification. The thermal gradient at the core-mantle boundary is subadiabatic, and hence the outer region of the liquid core is stably stratified with the dynamo operating only at depth, where a strong field is generated. Because of the planet's slow rotation the resulting magnetic field is dominated by small-scale components that fluctuate rapidly with time. The dynamo field diffuses through the stable conducting region, where rapidly varying parts are strongly attenuated by the skin effect, while the slowly varying dipole and quadrupole components pass to some degree. The model explains the observed structure and strength of Mercury's surface magnetic field and makes predictions that are testable with space missions both presently flying and planned.

Bubble mass center and fluid feedback force fluctuations activated by constant lateral impulse with variable thrust

NASA Technical Reports Server (NTRS)

Hung, R. J.; Long, Y. T.

1995-01-01

Sloshing dynamics within a partially filled rotating dewar of superfluid helium 2 are investigated in response to constant lateral impulse with variable thrust. The study, including how the rotating bubble of superfluid helium 2 reacts to the constant impulse with variable time period of thrust action in microgravity, how amplitudes of bubble mass center fluctuates with growth and decay of disturbances, and how fluid feedback forces fluctuates in activating on the rotating dewar through the dynamics of sloshing waves are investigated. The numerical computation of sloshing dynamics is based on the non-inertial frame spacecraft bound coordinate with lateral impulses actuating on the rotating dewar in both inertial and non-inertial frames of thrust. Results of the simulations are illustrated.

Cell Cycle-Dependent Expression of Dub3, Nanog and the p160 Family of Nuclear Receptor Coactivators (NCoAs) in Mouse Embryonic Stem Cells

PubMed Central

van der Laan, Siem; Golfetto, Eleonora; Vanacker, Jean-Marc; Maiorano, Domenico

2014-01-01

Pluripotency of embryonic stem cells (ESC) is tightly regulated by a network of transcription factors among which the estrogen-related receptor β (Esrrb). Esrrb contributes to the relaxation of the G1 to S-phase (G1/S) checkpoint in mouse ESCs by transcriptional control of the deubiquitylase Dub3 gene, contributing to Cdc25A persistence after DNA damage. We show that in mESCs, Dub3 gene expression is cell cycle regulated and is maximal prior G1/S transition. In addition, following UV-induced DNA damage in G1, Dub3 expression markedly increases in S-phase also suggesting a role in checkpoint recovery. Unexpectedly, we also observed cell cycle-regulation of Nanog expression, and not Oct4, reaching high levels prior to G1/S transition, finely mirroring Cyclin E1 fluctuations. Curiously, while Esrrb showed only limited cell-cycle oscillations, transcript levels of the p160 family of nuclear receptor coactivators (NCoAs) displayed strong cell cycle-dependent fluctuations. Since NCoAs function in concert with Esrrb in transcriptional activation, we focussed on NCoA1 whose levels specifically increase prior onset of Dub3 transcription. Using a reporter assay, we show that NCoA1 potentiates Esrrb-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 splice variant NCoA1 and Esrrb. Finally, we show a differential developmental regulation of all members of the p160 family during neural conversion of mESCs. These findings suggest that in mouse ESCs, changes in the relative concentration of a coactivator at a given cell cycle phase, may contribute to modulation of the transcriptional activity of the core transcription factors of the pluripotent network and be implicated in cell fate decisions upon onset of differentiation. PMID:24695638

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

PubMed

van der Laan, Siem; Golfetto, Eleonora; Vanacker, Jean-Marc; Maiorano, Domenico

2014-01-01

Pluripotency of embryonic stem cells (ESC) is tightly regulated by a network of transcription factors among which the estrogen-related receptor β (Esrrb). Esrrb contributes to the relaxation of the G1 to S-phase (G1/S) checkpoint in mouse ESCs by transcriptional control of the deubiquitylase Dub3 gene, contributing to Cdc25A persistence after DNA damage. We show that in mESCs, Dub3 gene expression is cell cycle regulated and is maximal prior G1/S transition. In addition, following UV-induced DNA damage in G1, Dub3 expression markedly increases in S-phase also suggesting a role in checkpoint recovery. Unexpectedly, we also observed cell cycle-regulation of Nanog expression, and not Oct4, reaching high levels prior to G1/S transition, finely mirroring Cyclin E1 fluctuations. Curiously, while Esrrb showed only limited cell-cycle oscillations, transcript levels of the p160 family of nuclear receptor coactivators (NCoAs) displayed strong cell cycle-dependent fluctuations. Since NCoAs function in concert with Esrrb in transcriptional activation, we focussed on NCoA1 whose levels specifically increase prior onset of Dub3 transcription. Using a reporter assay, we show that NCoA1 potentiates Esrrb-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 splice variant NCoA1 and Esrrb. Finally, we show a differential developmental regulation of all members of the p160 family during neural conversion of mESCs. These findings suggest that in mouse ESCs, changes in the relative concentration of a coactivator at a given cell cycle phase, may contribute to modulation of the transcriptional activity of the core transcription factors of the pluripotent network and be implicated in cell fate decisions upon onset of differentiation.

Circadian oscillatory transcriptional programs in grapevine ripening fruits

PubMed Central

2014-01-01

Background Temperature and solar radiation influence Vitis vinifera L. berry ripening. Both environmental conditions fluctuate cyclically on a daily period basis and the strength of this fluctuation affects grape ripening too. Additionally, a molecular circadian clock regulates daily cyclic expression in a large proportion of the plant transcriptome modulating multiple developmental processes in diverse plant organs and developmental phases. Circadian cycling of fruit transcriptomes has not been characterized in detail despite their putative relevance in the final composition of the fruit. Thus, in this study, gene expression throughout 24 h periods in pre-ripe berries of Tempranillo and Verdejo grapevine cultivars was followed to determine whether different ripening transcriptional programs are activated during certain times of day in different grape tissues and genotypes. Results Microarray analyses identified oscillatory transcriptional profiles following circadian variations in the photocycle and the thermocycle. A higher number of expression oscillating transcripts were detected in samples carrying exocarp tissue including biotic stress-responsive transcripts activated around dawn. Thermotolerance-like responses and regulation of circadian clock-related genes were observed in all studied samples. Indeed, homologs of core clock genes were identified in the grapevine genome and, among them, VvREVEILLE1 (VvRVE1), showed a consistent circadian expression rhythm in every grape berry tissue analysed. Light signalling components and terpenoid biosynthetic transcripts were specifically induced during the daytime in Verdejo, a cultivar bearing white-skinned and aromatic berries, whereas transcripts involved in phenylpropanoid biosynthesis were more prominently regulated in Tempranillo, a cultivar bearing black-skinned berries. Conclusions The transcriptome of ripening fruits varies in response to daily environmental changes, which might partially be under the control of circadian clock components. Certain cultivar and berry tissue features could rely on specific circadian oscillatory expression profiles. These findings may help to a better understanding of the progress of berry ripening in short term time scales. PMID:24666982

Linkages of fracture network geometry and hydro-mechanical properties to spatio-temporal variations of seismicity in Koyna-Warna Seismic Zone

NASA Astrophysics Data System (ADS)

Selles, A.; Mikhailov, V. O.; Arora, K.; Ponomarev, A.; Gopinadh, D.; Smirnov, V.; Srinu, Y.; Satyavani, N.; Chadha, R. K.; Davulluri, S.; Rao, N. P.

2017-12-01

Well logging data and core samples from the deep boreholes in the Koyna-Warna Seismic Zone (KWSZ) provided a glimpse of the 3-D fracture network responsible for triggered earthquakes in the region. The space-time pattern of earthquakes during the last five decades show strong linkage of favourably oriented fractures system deciphered from airborne LiDAR and borehole structural logging to the seismicity. We used SAR interferometry data on surface displacements to estimate activity of the inferred faults. The failure in rocks at depths is largely governed by overlying lithostatic and pore fluid pressure in the rock matrix which are subject to change in space and time. While lithostatic pressure tends to increase with depth pore pressure is prone to fluctuations due to any change in the hydrological regime. Based on the earthquake catalogue data, the seasonal variations in seismic activity associated with annual fluctuations in the reservoir water level were analyzed over the time span of the entire history of seismological observations in this region. The regularities in the time changes in the structure of seasonal variations are revealed. An increase in pore fluid pressure can result in rock fracture and oscillating pore fluid pressures due to a reservoir loading and unloading cycles can cause iterative and cumulative damage, ultimately resulting in brittle failure under relatively low effective mean stress conditions. These regularities were verified by laboratory physical modeling. Based on our observations of main trends of spatio-temporal variations in seismicity as well as the spatial distribution of fracture network a conceptual model is presented to explain the triggered earthquakes in the KWSZ. The work was supported under the joint Russian-Indian project of the Russian Science Foundation (RSF) and the Department of Science and Technology (DST) of India (RSF project no. 16-47-02003 and DST project INT/RUS/RSF/P-13).

Effect of Water-Table Fluctuations on Source Depletion and Dissolved-Plume Behavior of a Multi-Component Light Nonaqueous-Phase Liquid

NASA Astrophysics Data System (ADS)

Dobson, R.; Schroth, M. H.; Zeyer, J.

2006-12-01

Light nonaqueous-phase liquids (LNAPLs) such as gasoline and diesel are among the most common soil and groundwater contaminants. Dissolution and subsequent advective transport of LNAPL components can negatively impact downgradient water supplies, while biodegradation is commonly thought to be an important sink for this class of contaminants. Water-table fluctuations, either naturally occurring or intentionally induced, may affect LNAPL component transport and biodegradation in aquifers. We present a laboratory investigation of the effect of water-table fluctuations on the dissolution and biodegradation of a multi-component LNAPL in a pair of similar model aquifers, one of which was subjected to a water-table fluctuation. Water-table fluctuation resulted in LNAPL and air entrapment below the water table, an increase in the vertical extent of LNAPL contamination and an increase in the volume of water passing through the contaminated zone. Effluent concentrations of dissolved LNAPL components were higher and those of dissolved nitrate were lower in the aquifer model where a fluctuation had been induced. Thus, water table fluctuation led to enhanced LNAPL dissolution as well as enhanced biodegradation activity. The increase in biodegradation observed after fluctuation was of lesser magnitude than the increase in LNAPL dissolution, such that water-table fluctuations might be expected to result in increased exposure of downgradient receptors to dissolved LNAPL components. Conversely, the potential for free-phase LNAPL migration was reduced following a water-table fluctuation, as LNAPL entrapment by the rising water table reduced the amount of free phase LNAPL. Lateral migration of LNAPL following emplacement was observed in the model aquifer where no fluctuation occurred, but not in the model aquifer where a water-table fluctuation was induced.

Practical passive decoy state measurement-device-independent quantum key distribution with unstable sources.

PubMed

Liu, Li; Guo, Fen-Zhuo; Wen, Qiao-Yan

2017-09-12

Measurement-device-independent quantum key distribution (MDI-QKD) with the active decoy state method can remove all detector loopholes, and resist the imperfections of sources. But it may lead to side channel attacks and break the security of QKD system. In this paper, we apply the passive decoy state method to the MDI-QKD based on polarization encoding mode. Not only all attacks on detectors can be removed, but also the side channel attacks on sources can be overcome. We get that the MDI-QKD with our passive decoy state method can have a performance comparable to the protocol with the active decoy state method. To fit for the demand of practical application, we discuss intensity fluctuation in the security analysis of MDI-QKD protocol using passive decoy state method, and derive the key generation rate for our protocol with intensity fluctuation. It shows that intensity fluctuation has an adverse effect on the key generation rate which is non-negligible, especially in the case of small data size of total transmitting signals and long distance transmission. We give specific simulations on the relationship between intensity fluctuation and the key generation rate. Furthermore, the statistical fluctuation due to the finite length of data is also taken into account.

Equilibrium and out-of-equilibrium mechanics of living mammalian cytoplasm

NASA Astrophysics Data System (ADS)

Gupta, Satish Kumar; Guo, Ming

2017-10-01

Living cells are intrinsically non-equilibrium systems. They are driven out of equilibrium by the activity of the molecular motors and other enzymatic processes. This activity along with the ever present thermal agitation results in intracellular fluctuations inside the cytoplasm. In analogy to Brownian motion, the material property of the cytoplasm also influences the characteristics of these fluctuations. In this paper, through a combination of experimentation and theoretical analysis, we show that intracellular fluctuations are indeed due to non-thermal forces at relatively long time-scales, however, are dominated solely by thermal forces at relatively short time-scales. Thus, the cytoplasm of living mammalian cells behaves as an equilibrium material at short time-scales. The mean square displacement of these intracellular fluctuations scales inversely with the cytoplasmic shear modulus in this short time-scale equilibrium regime, and is inversely proportional to the square of the cytoplasmic shear modulus in the long time-scale out-of-equilibrium regime. Furthermore, we deploy passive microrheology based on these fluctuations to extract the mechanical property of the cytoplasm at the high-frequency regime. We show that the cytoplasm of living mammalian cells is a weak elastic gel in this regime; this is in an excellent agreement with an independent micromechanical measurement using optical tweezers.

Measurement of the complete core plasma flow across the LOC-SOC transition at ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Lebschy, A.; McDermott, R. M.; Angioni, C.; Geiger, B.; Prisiazhniuk, D.; Cavedon, M.; Conway, G. D.; Dux, R.; Dunne, M. G.; Kappatou, A.; Pütterich, T.; Stroth, U.; Viezzer, E.; the ASDEX Upgrade Team

2018-02-01

A newly installed core charge exchange recombination spectroscopy (CXRS) diagnostic at ASDEX Upgrade (AUG) enables the evaluation of the core poloidal rotation (upol ) through the inboard-outboard asymmetry of the toroidal rotation with an accuracy of 0.5 to 1 km s-1 . Using this technique, the total plasma flow has been measured in Ohmic L-mode plasmas across the transition from the linear to saturated ohmic confinement (LOC-SOC) regimes. The core poloidal rotation of the plasma around mid-radius is found to be always in the ion diamagnetic direction, in disagreement with neoclassical (NC) predictions. The edge rotation is found to be electron-directed and consistent with NC codes. This measurement provides as well the missing ingredient to evaluate the core E×B velocity (uE×B ) from data only, which can then be compared to measurements of the perpendicular velocity of the turbulent fluctuations (u\\perp ) to gain information on the turbulent phase velocity (vph ). The non neoclassical upol from CXRS leads to good agreement between uE×B and u\\perp indicating that vph is small and at similar values as found with gyrokinetic simulations. Moreover, the data shows a shift of vph in the ion-diamagnetic direction at the edge after the transition from LOC to SOC consistent with a change in the dominant turbulence regime. The upgrade of the core CXRS system provides as well a deeper insight into the intrinsic rotation. This paper shows that the reversal of the core toroidal rotation occurs clearly after the LOC-SOC transition and concomitant with the peaking of the electron density.

Onset and Multiple Fluctuations of Holocene Glaciation in the Sierra Nevada, California

NASA Astrophysics Data System (ADS)

Bowerman, N. D.; Clark, D. H.

2004-12-01

Multiple sediment cores from two paternoster tarns (First and Second lakes) in North Fork Big Pine Creek, Sierra Nevada, preserve the most detailed and complete record of Holocene glaciation yet recovered in the range; they indicate that the glacier was absent during the early Holocene, reformed in the late Holocene, and experienced several expansions and contractions, culminating with the Matthes maximum during the last ˜200 years. The lakes are fed by outwash from the Palisade Glacier, the largest ( ˜1.3 km2) and presumably longest-lived glacier in the Sierra Nevada, and capture essentially all of the rock flour produced by the glacier. Distinct late-Holocene (Matthes) and late-Pleistocene (Recess Peak) moraines lie between the modern glacier and the lakes. Thus, the lakes have received continuous sedimentation since the retreat of the Tioga glacier ( ˜15,000 yr B.P.), and therefore capture rock flour related to all subsequent advances. First and Second lakes occupy relatively deep bedrock basins at 3036 m and 3066 m asl., respectively. Third Lake, a shallow (<3 m deep), moraine-dammed lake that lies directly above Second Lake, is the only lake between the Palisade Glacier and the lower lakes. As such, it captures the coarsest (sand/gravel bedload) outwash, but abundant suspended sediment (silt/clay) continues to the lower lakes. We cored the lakes using both Reasoner and Livingston corers, to sediment depths of up to ˜5 m. The deepest cores bottomed in coarse, inorganic sand and silt that we interpret as outwash or slopewash related to Tioga deglaciation. Magnetic susceptibility (MS) analyses of the sediment cores indicate that both lakes record multiple late-Holocene peaks in MS, with the most recent peak being the largest. They also retain outwash near the base related to the more extensive Recess Peak advance. MS peaks in Sierran lakes typically indicate greater abundances of clastic (vs. organic) sediment. The peaks in our cores thus imply 4-5 periods of increased flux of rock flour (outwash) from the upstream Palisade Glacier, most likely related to formation and expansions of the glacier in the late Holocene. The maximum peak at the top of the cores confirms the moraine record, which indicates that the maximum Holocene advance of Sierran glaciers occurred during the late Little Ice Age (last ˜200 yr) At least one tephra layer, possibly related to the Mono/Inyo dome complexes, occurs in the middle depths of the First Lake cores. Other narrow peaks in MS may also be associated with tephra deposits. Ongoing detailed analyses of the sediments, including AMS radiocarbon dating, visual and x-ray imaging, particle size analysis, organic content, tephrochronology, diatom assemblages, and palynology will constrain the timing and character of the environmental fluctuations related to the rock-flour flux. We will present results of these analyses at the meeting.

Time-frequency analysis of transient signals - application to cardiovascular control

NASA Astrophysics Data System (ADS)

Keselbrener, Laurence; Akselrod, Solange

A method for time-frequency decomposition (SDA) is presented for the analysis of cardiovascular signals, during steady state as well as under transient conditions. The SDA is applied to a simulated noisy non-stationary signal. It reliably discloses the time evolution of the different spectral components of the signal and does not present noise propagation as other time-frequency methods, such as Wigner-Ville distribution does. A comparison with the well-known short-time Fourier transform is also performed for non-stationary simulated signal showing that the SDA achieves a higher time-frequency resolution. Two physiological applications are then presented in which the SDA is used for the analysis of HR and BP variability, reflecting the activity of the autonomic nervous system. The power spectra of heart rate (HR) and blood pressure (BP) fluctuations during a change of posture from supine to standing are calculated. The decrease of vagal activity on standing is obvious and can be quantified from the spectrum of HR fluctuations. The increase in the LF fluctuations of both BP and HR spectra reflect the enhancement in sympathetic activity on standing. Finally, the power spectrum of fetal HR fluctuations is obtained by SDA. The respiratory peak is observed and can help in evaluating fetal well-being.

Fluctuations in Species-Level Protein Expression Occur during Element and Nutrient Cycling in the Subsurface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkins, Michael J.; Wrighton, Kelly C.; Nicora, Carrie D.

2013-03-05

While microbial activities in environmental systems play a key role in the utilization and cycling of essential elements and compounds, microbial activity and growth frequently fluctuates in response to environmental stimuli and perturbations. To investigate these fluctuations within a saturated aquifer system, we monitored a carbon-stimulated in situ Geobacter population while iron reduction was occurring, using 16S rRNA abundances and high-resolution tandem mass spectrometry proteome measurements. Following carbon amendment, 16S rRNA analysis of temporally separated samples revealed the rapid enrichment of Geobacter-like environmental strains with strong similarity to G. bemidjiensis. Tandem mass spectrometry proteomics measurements suggest high carbon flux throughmore » Geobacter respiratory pathways, and the synthesis of anapleurotic four carbon compounds from acetyl-CoA via pyruvate ferredoxin oxidoreductase activity. Across a 40-day period where Fe(III) reduction was occurring, fluctuations in protein expression reflected changes in anabolic versus catabolic reactions, with increased levels of biosynthesis occurring soon after acetate arrival in the aquifer. In addition, localized shifts in nutrient limitation were inferred based on expression of nitrogenase enzymes and phosphate uptake proteins. These temporal data offer the first example of differing microbial protein expression associated with changing geochemical conditions in a subsurface environment.« less

The role of the circadian system in fractal neurophysiological control

PubMed Central

Pittman-Polletta, Benjamin R.; Scheer, Frank A.J.L.; Butler, Matthew P.; Shea, Steven A.; Hu, Kun

2013-01-01

Many neurophysiological variables such as heart rate, motor activity, and neural activity are known to exhibit intrinsic fractal fluctuations - similar temporal fluctuation patterns at different time scales. These fractal patterns contain information about health, as many pathological conditions are accompanied by their alteration or absence. In physical systems, such fluctuations are characteristic of critical states on the border between randomness and order, frequently arising from nonlinear feedback interactions between mechanisms operating on multiple scales. Thus, the existence of fractal fluctuations in physiology challenges traditional conceptions of health and disease, suggesting that high levels of integrity and adaptability are marked by complex variability, not constancy, and are properties of a neurophysiological network, not individual components. Despite the subject's theoretical and clinical interest, the neurophysiological mechanisms underlying fractal regulation remain largely unknown. The recent discovery that the circadian pacemaker (suprachiasmatic nucleus) plays a crucial role in generating fractal patterns in motor activity and heart rate sheds an entirely new light on both fractal control networks and the function of this master circadian clock, and builds a bridge between the fields of circadian biology and fractal physiology. In this review, we sketch the emerging picture of the developing interdisciplinary field of fractal neurophysiology by examining the circadian system’s role in fractal regulation. PMID:23573942

One-year measurements of chloroethenes in tree cores and groundwater at the SAP Mimoň Site, Northern Bohemia.

PubMed

Wittlingerova, Z; Machackova, J; Petruzelkova, A; Trapp, S; Vlk, K; Zima, J

2013-02-01

Chlorinated ethenes (CE) are among the most frequent contaminants of soil and groundwater in the Czech Republic. Because conventional methods of subsurface contamination investigation are costly and technically complicated, attention is directed on alternative and innovative field sampling methods. One promising method is sampling of tree cores (plugs of woody tissue extracted from a host tree). Volatile organic compounds can enter into the trunks and other tissues of trees through their root systems. An analysis of the tree core can thus serve as an indicator of the subsurface contamination. Four areas of interest were chosen at the experimental site with CE groundwater contamination and observed fluctuations in groundwater concentrations. CE concentrations in groundwater and tree cores were observed for a 1-year period. The aim was to determine how the CE concentrations in obtained tree core samples correlate with the level of contamination of groundwater. Other factors which can affect the transfer of contaminants from groundwater to wood were also monitored and evaluated (e.g., tree species and age, level of groundwater table, river flow in the nearby Ploučnice River, seasonal effects, and the effect of the remediation technology operation). Factors that may affect the concentration of CE in wood were identified. The groundwater table level, tree species, and the intensity of transpiration appeared to be the main factors within the framework of the experiment. Obtained values documented that the results of tree core analyses can be used to indicate the presence of CE in the subsurface. The results may also be helpful to identify the best sampling period for tree coring and to learn about the time it takes until tree core concentrations react to changes in groundwater conditions. Interval sampling of tree cores revealed possible preservation of the contaminant in the wood of trees.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cadavid, A. C.; Lawrence, J. K.; Christian, D. J.

We investigate the scaling properties of the long-range temporal evolution and intermittency of Atmospheric Imaging Assembly/ Solar Dynamics Observatory intensity observations in four solar environments: an active region core, a weak emission region, and two core loops. We use two approaches: the probability distribution function (PDF) of time series increments and multifractal detrended fluctuation analysis (MF-DFA). Noise taints the results, so we focus on the 171 Å waveband, which has the highest signal-to-noise ratio. The lags between pairs of wavebands distinguish between coronal versus transition region (TR) emission. In all physical regions studied, scaling in the range of 15–45 minutesmore » is multifractal, and the time series are anti-persistent on average. The degree of anti-correlation in the TR time series is greater than that for coronal emission. The multifractality stems from long-term correlations in the data rather than the wide distribution of intensities. Observations in the 335 Å waveband can be described in terms of a multifractal with added noise. The multiscaling of the extreme-ultraviolet data agrees qualitatively with the radiance from a phenomenological model of impulsive bursts plus noise, and also from ohmic dissipation in a reduced magnetohydrodynamic model for coronal loop heating. The parameter space must be further explored to seek quantitative agreement. Thus, the observational “signatures” obtained by the combined tests of the PDF of increments and the MF-DFA offer strong constraints that can systematically discriminate among models for coronal heating.« less

Benthic Archives Reveal Recurrence and Dominance of Toxigenic Cyanobacteria in a Eutrophic Lake over the Last 220 Years.

PubMed

Legrand, Benjamin; Lamarque, Amélie; Sabart, Marion; Latour, Delphine

2017-09-04

Akinetes are resistant cells which have the ability to persist in sediment for several decades. We have investigated the temporal distribution of akinetes of two species, Dolichospermum macrosporum and Dolichospermum flos-aquae , in a sediment core sampled in Lake Aydat (France), which covers 220 years. The upper part, from 1907 to 2016, the number of akinetes fluctuated but stayed at high concentrations, especially for D. macrosporum in surface sediment (with the maximal value close to 6.10⁵ akinetes g DW -1 of sediment), suggesting a recurrence of blooms of this species which was probably closely related to anthropic eutrophication since the 1960s. Before 1907, the abundance of akinetes of both species was very low, suggesting only a modest presence of these cyanobacteria. In addition, the percentage of intact akinetes was different for each species, suggesting different ecological processes in the water column. This percentage also decreased with depth, revealing a reduction in germination potential over time. In addition, biosynthetic genes of anatoxin-a ( anaC ) and microcystin ( mcyA ) were detected. First results show a high occurrence of mcyA all down the core. In contrast, anaC gene was mostly detected in the surface sediment (since the 1980s), revealing a potentially more recent occurrence of this cyanotoxin in Lake Aydat which may be associated with the recurrence of blooms of D. macrosporum and thus with anthropic activities.

Jasmonate-triggered plant immunity.

PubMed

Campos, Marcelo L; Kang, Jin-Ho; Howe, Gregg A

2014-07-01

The plant hormone jasmonate (JA) exerts direct control over the production of chemical defense compounds that confer resistance to a remarkable spectrum of plant-associated organisms, ranging from microbial pathogens to vertebrate herbivores. The underlying mechanism of JA-triggered immunity (JATI) can be conceptualized as a multi-stage signal transduction cascade involving: i) pattern recognition receptors (PRRs) that couple the perception of danger signals to rapid synthesis of bioactive JA; ii) an evolutionarily conserved JA signaling module that links fluctuating JA levels to changes in the abundance of transcriptional repressor proteins; and iii) activation (de-repression) of transcription factors that orchestrate the expression of myriad chemical and morphological defense traits. Multiple negative feedback loops act in concert to restrain the duration and amplitude of defense responses, presumably to mitigate potential fitness costs of JATI. The convergence of diverse plant- and non-plant-derived signals on the core JA module indicates that JATI is a general response to perceived danger. However, the modular structure of JATI may accommodate attacker-specific defense responses through evolutionary innovation of PRRs (inputs) and defense traits (outputs). The efficacy of JATI as a defense strategy is highlighted by its capacity to shape natural populations of plant attackers, as well as the propensity of plant-associated organisms to subvert or otherwise manipulate JA signaling. As both a cellular hub for integrating informational cues from the environment and a common target of pathogen effectors, the core JA module provides a focal point for understanding immune system networks and the evolution of chemical diversity in the plant kingdom.

Widespread Nanoflare Variability Detected with Hinode/XRT in a Solar Active Region

NASA Technical Reports Server (NTRS)

Reale, Fabio; Terzo, Sergio; Miceli, Marco; Klimchuk, James A.; Kano, Ryouhei; Tsuneta, Saku

2011-01-01

It is generally agreed that small impulsive energy bursts called nanoflares are responsible for at least some of the Sun s hot corona, but whether they are the explanation for most of the multi-million degree plasma has been a matter of ongoing debate. We here present evidence that nanoflares are widespread in an active region observed by the X-Ray Telescope on-board the Hinode mission. The distributions of intensity fluctuations have small but important asymmetries, whether taken from individual pixels, multi-pixel subregions, or the entire active region. Negative fluctuations (corresponding to reduced intensity) are greater in number but weaker in amplitude, so that the median fluctuation is negative compared to a mean of zero. Using Monte Carlo simulations, we show that only part of this asymmetry can be explained by Poisson photon statistics. The remainder is explainable with a tendency for exponentially decreasing intensity, such as would be expected from a cooling plasma produced, e.g., from a nanoflare. We suggest that nanoflares are a universal heating process within active regions.

Characterizing active cytoskeletal dynamics with magnetic microposts

NASA Astrophysics Data System (ADS)

Shi, Yu; Henry, Steven; Crocker, John; Reich, Daniel

Characterization of an active matter system such as the cellular cytoskeleton requires knowledge of three frequency dependent quantities: the dynamic shear modulus, G*(ω) describing its viscoelasticity, the Fourier power spectrum of forces in the material due to internal force generators f (ω) , and the spectrum of the material's active strain fluctuations x(ω) . Via use of PDMS micropost arrays with magnetic nanowires embedded in selected posts, we measure the local complex modulus of cells through mechanical actuation of the magnetic microposts. The micrometer scale microposts are also used as passive probes to measure simultaneously the frequency dependent strain fluctuations. We present data on 3T3 fibroblasts, where we find power law behavior for both the frequency dependence of cells' modulus | G (ω) | ω 0 . 27 and the power spectrum of strain fluctuations |x(ω) | ω-2 . Results for the power spectrum of active cytoskeletal stresses determined from these two measurements, and implications of this mesoscale characterization of cytoskeletal dynamics for cellular biophysics will also be discussed. Supported in part by NIH Grant 1R01HL127087.

DNS investigation of the dynamical behaviour of trailing vortices in unbaffled stirred vessels at transitional Reynolds numbers

NASA Astrophysics Data System (ADS)

Başbuǧ, S.; Papadakis, G.; Vassilicos, J. C.

2017-06-01

Flow in an unbaffled stirred vessel agitated by a four-bladed radial impeller is investigated by using direct numerical simulations at Re = 320 and 1600. We observe fluctuations in the power consumption with a peak frequency at ca. three times the impeller rotational speed for both Reynolds numbers. It is discovered that these fluctuations are associated with a periodic event in the wake of the blades, which involves alternating growth and decay of the upper and lower cores of the trailing vortex pair as well as up-and-down swinging motion of the radial jet. Moreover, the phase relation between the wakes of the different blades is examined in detail. Further studies using fractal-shaped blades show that the exact blade shape does not have a strong influence on this phenomenon. However, the wake interaction between the blades, hence the number of blades, has a direct influence on the unsteadiness of trailing vortices.

Microturbulence studies of pulsed poloidal current drive discharges in the reversed field pinch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carmody, D., E-mail: dcarmody@wisc.edu; Pueschel, M. J.; Anderson, J. K.

2015-01-15

Experimental discharges with pulsed poloidal current drive (PPCD) in the Madison Symmetric Torus reversed field pinch are investigated using a semi-analytic equilibrium model in the gyrokinetic turbulence code GENE. PPCD cases, with plasma currents of 500 kA and 200 kA, exhibit a density-gradient-driven trapped electron mode (TEM) and an ion temperature gradient mode, respectively. Relative to expectations of tokamak core plasmas, the critical gradients for the onset of these instabilities are found to be greater by roughly a factor of the aspect ratio. A significant upshift in the nonlinear TEM transport threshold, previously found for tokamaks, is confirmed in nonlinear reversed fieldmore » pinch simulations and is roughly three times the threshold for linear instability. The simulated heat fluxes can be brought in agreement with measured diffusivities by introducing a small, resonant magnetic perturbation, thus modeling the residual fluctuations from tearing modes. These fluctuations significantly enhance transport.« less

Dynamic stability of nano-fibers self-assembled from short amphiphilic A6D peptides

NASA Astrophysics Data System (ADS)

Nikoofard, Narges; Maghsoodi, Fahimeh

2018-04-01

Self-assembly of A6D amphiphilic peptides in explicit water is studied by using coarse-grained molecular dynamics simulations. It is observed that the self-assembly of randomly distributed A6D peptides leads to the formation of a network of nano-fibers. Two other simulations with cylindrical nano-fibers as the initial configuration show the dynamic stability of the self-assembled nano-fibers. As a striking feature, notable fluctuations occur along the axes of the nano-fibers. Depending on the number of peptides per unit length of the nano-fiber, flat-shaped bulges or spiral shapes along the nano-fiber axis are observed at the fluctuations. Analysis of the particle distribution around the nano-fiber indicates that the hydrophobic core and the hydrophilic shell of the nano-structure are preserved in both simulations. The size of the deformations and their correlation times are different in the two simulations. This study gives new insights into the dynamics of the self-assembled nano-structures of short amphiphilic peptides.

Studies of Turbulence and Transport in Alcator C-Mod H-Mode Plasmas with Phase Contrast Imaging and Comparisons with GYRO

NASA Astrophysics Data System (ADS)

Porkolab, M.; Lin, L.; Edlund, E. M.; Rost, J. C.; Fiore, C. L.; Greenwald, M.; Mikkelsen, D.

2008-11-01

We present recent experimental measurements of turbulence and transport in C-Mod H-Mode plasmas with and without internal transport barriers (ITB) using the phase contrast imaging (PCI) diagnostic and compare the results with GYRO predictions. In plasmas without ITB, the fluctuation above 300 kHz observed by PCI agrees with ITG in GYRO simulation, including the direction of propagation, wavenumber spectrum, and absolute intensity within experimental uncertainly (+/-75%). After transition to ITBs, the observed overall fluctuation intensity increases. GYRO simulation in the core shows that ITG dominates in ITBs but its intensity is lower than the overall experimental measurements which may also include contributions from the plasma edge. These results, as well as the impact of varying ∇Ti, ∇n, and ExB shear on turbulence will be discussed. C.L. Fiore et al., Fusion Sci. Technol., 51, 303 (2007). M. Porkolab et al., IEEE Trans. Plasma Sci. 34, 229 (2006). J. Candy et al., Phys. Rev. Lett., 91, 045001 (2003).

Dynamic stability of nano-fibers self-assembled from short amphiphilic A6D peptides.

PubMed

Nikoofard, Narges; Maghsoodi, Fahimeh

2018-04-07

Self-assembly of A 6 D amphiphilic peptides in explicit water is studied by using coarse-grained molecular dynamics simulations. It is observed that the self-assembly of randomly distributed A 6 D peptides leads to the formation of a network of nano-fibers. Two other simulations with cylindrical nano-fibers as the initial configuration show the dynamic stability of the self-assembled nano-fibers. As a striking feature, notable fluctuations occur along the axes of the nano-fibers. Depending on the number of peptides per unit length of the nano-fiber, flat-shaped bulges or spiral shapes along the nano-fiber axis are observed at the fluctuations. Analysis of the particle distribution around the nano-fiber indicates that the hydrophobic core and the hydrophilic shell of the nano-structure are preserved in both simulations. The size of the deformations and their correlation times are different in the two simulations. This study gives new insights into the dynamics of the self-assembled nano-structures of short amphiphilic peptides.

Flow Instabilities in Feather Seals due to Upstream Harmonic Pressure Fluctuations

NASA Technical Reports Server (NTRS)

Deng, D.; Braun, M. J.; Henricks, Robert C.

2008-01-01

Feather seals (also called slot seals) typically found in turbine stators limit leakage from the platform into the core cavities and from the shroud to the case. They are of various geometric shapes, yet all are contoured to fit the aerodynamic shape of the stator and placed as close as thermomechanically reasonable the powerstream flow passage. Oscillations engendered in the compressor or combustor alter the steady leakage characteristics of these sealing elements and in some instances generate flow instabilities downstream of the seal interface. In this study, a generic feather seal geometry was studied numerically by imposing an upstream harmonic pressure disturbance on the simulated stator-blade gap. The flow and thermal characteristics were determined; it was found that for high pressure drops, large fluctuations in flows in the downstream blade-stator gap can occur. These leakages and pulsations in themselves are not all that significant, yet if coupled with cavity parameters, they could set up resonance events. Computationally generated time-dependent flow fields are captured in sequence video streaming.

Statistical description of the motion of dislocation kinks in a random field of impurities adsorbed by a dislocation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Petukhov, B. V., E-mail: petukhov@ns.crys.ras.r

2010-01-15

A model has been proposed for describing the influence of impurities adsorbed by dislocation cores on the mobility of dislocation kinks in materials with a high crystalline relief (Peierls barriers). The delay time spectrum of kinks at statistical fluctuations of the impurity density has been calculated for a sufficiently high energy of interaction between impurities and dislocations when the migration potential is not reduced to a random Gaussian potential. It has been shown that fluctuations in the impurity distribution substantially change the character of the migration of dislocation kinks due to the slow decrease in the probability of long delaymore » times. The dependences of the position of the boundary of the dynamic phase transition to a sublinear drift of kinks x {proportional_to} t{sup {delta}} ({delta} {sigma} 1) and the characteristics of the anomalous mobility on the physical parameters (stress, impurity concentration, experimental temperature, etc.) have been calculated.« less

Dynamical transition, hydrophobic interface, and the temperature dependence of electrostatic fluctuations in proteins.

PubMed

Lebard, David N; Matyushov, Dmitry V

2008-12-01

Molecular dynamics simulations have revealed a dramatic increase, with increasing temperature, of the amplitude of electrostatic fluctuations caused by water at the active site of metalloprotein plastocyanin. The increased breadth of electrostatic fluctuations, expressed in terms of the reorganization energy of changing the redox state of the protein, is related to the formation of the hydrophobic protein-water interface, allowing large-amplitude collective fluctuations of the water density in the protein's first solvation shell. On top of the monotonic increase of the reorganization energy with increasing temperature, we have observed a spike at approximately 220 K also accompanied by a significant slowing of the exponential collective Stokes shift dynamics. In contrast to the local density fluctuations of the hydration-shell waters, these spikes might be related to the global property of the water solvent crossing the Widom line or undergoing a weak first-order transition.

Zero-point fluctuations in naphthalene and their effect on charge transport parameters.

PubMed

Kwiatkowski, Joe J; Frost, Jarvist M; Kirkpatrick, James; Nelson, Jenny

2008-09-25

We calculate the effect of vibronic coupling on the charge transport parameters in crystalline naphthalene, between 0 and 400 K. We find that nuclear fluctuations can cause large changes in both the energy of a charge on a molecule and on the electronic coupling between molecules. As a result, nuclear fluctuations cause wide distributions of both energies and couplings. We show that these distributions have a small temperature dependence and that, even at high temperatures, vibronic coupling is dominated by the effect of zero-point fluctuations. Because of the importance of zero-point fluctuations, we find that the distributions of energies and couplings have substantial width, even at 0 K. Furthermore, vibronic coupling with high energy modes may be significant, even though these modes are never thermally activated. Our results have implications for the temperature dependence of charge mobilities in organic semiconductors.

On the Structure of Neuronal Population Activity under Fluctuations in Attentional State

PubMed Central

Denfield, George H.; Bethge, Matthias; Tolias, Andreas S.

2016-01-01

Attention is commonly thought to improve behavioral performance by increasing response gain and suppressing shared variability in neuronal populations. However, both the focus and the strength of attention are likely to vary from one experimental trial to the next, thereby inducing response variability unknown to the experimenter. Here we study analytically how fluctuations in attentional state affect the structure of population responses in a simple model of spatial and feature attention. In our model, attention acts on the neural response exclusively by modulating each neuron's gain. Neurons are conditionally independent given the stimulus and the attentional gain, and correlated activity arises only from trial-to-trial fluctuations of the attentional state, which are unknown to the experimenter. We find that this simple model can readily explain many aspects of neural response modulation under attention, such as increased response gain, reduced individual and shared variability, increased correlations with firing rates, limited range correlations, and differential correlations. We therefore suggest that attention may act primarily by increasing response gain of individual neurons without affecting their correlation structure. The experimentally observed reduction in correlations may instead result from reduced variability of the attentional gain when a stimulus is attended. Moreover, we show that attentional gain fluctuations, even if unknown to a downstream readout, do not impair the readout accuracy despite inducing limited-range correlations, whereas fluctuations of the attended feature can in principle limit behavioral performance. SIGNIFICANCE STATEMENT Covert attention is one of the most widely studied examples of top-down modulation of neural activity in the visual system. Recent studies argue that attention improves behavioral performance by shaping of the noise distribution to suppress shared variability rather than by increasing response gain. Our work shows, however, that latent, trial-to-trial fluctuations of the focus and strength of attention lead to shared variability that is highly consistent with known experimental observations. Interestingly, fluctuations in the strength of attention do not affect coding performance. As a consequence, the experimentally observed changes in response variability may not be a mechanism of attention, but rather a side effect of attentional allocation strategies in different behavioral contexts. PMID:26843656

Relationships between lake-level changes and water and salt budgets in the Dead Sea during extreme aridities in the Eastern Mediterranean

NASA Astrophysics Data System (ADS)

Kiro, Yael; Goldstein, Steven L.; Garcia-Veigas, Javier; Levy, Elan; Kushnir, Yochanan; Stein, Mordechai; Lazar, Boaz

2017-04-01

Thick halite intervals recovered by the Dead Sea Deep Drilling Project cores show evidence for severely arid climatic conditions in the eastern Mediterranean during the last three interglacials. In particular, the core interval corresponding to the peak of the last interglacial (Marine Isotope Stage 5e or MIS 5e) contains ∼30 m of salt over 85 m of core length, making this the driest known period in that region during the late Quaternary. This study reconstructs Dead Sea lake levels during the salt deposition intervals, based on water and salt budgets derived from the Dead Sea brine composition and the amount of salt in the core. Modern water and salt budgets indicate that halite precipitates only during declining lake levels, while the amount of dissolved Na+ and Cl- accumulates during wetter intervals. Based on the compositions of Dead Sea brines from pore waters and halite fluid inclusions, we estimate that ∼12-16 cm of halite precipitated per meter of lake-level drop. During periods of halite precipitation, the Mg2+ concentration increases and the Na+/Cl- ratio decreases in the lake. Our calculations indicate major lake-level drops of ∼170 m from lake levels of 320 and 310 m below sea level (mbsl) down to lake levels of ∼490 and ∼480 mbsl, during MIS 5e and the Holocene, respectively. These lake levels are much lower than typical interglacial lake levels of around 400 mbsl. These lake-level drops occurred as a result of major decreases in average fresh water runoff, to ∼40% of the modern value (pre-1964, before major fresh water diversions), reflecting severe droughts during which annual precipitation in Jerusalem was lower than 350 mm/y, compared to ∼600 mm/y today. Nevertheless, even during salt intervals, the changes in halite facies and the occurrence of alternating periods of halite and detritus in the Dead Sea core stratigraphy reflect fluctuations between drier and wetter conditions around our estimated average. The halite intervals include periods that are richer and poorer in halite, indicating (based on the sedimentation rate) that severe dry conditions with water availability as low as ∼20% of the present day, continued for periods of decades to centuries, and fluctuated with wetter conditions that spanned centuries to millennia when water availability was ∼50-100% of the present day. These conclusions have potential implications for the coming decades, as climate models predict greater aridity in the region.

Interpreting irregularity in small-scale, cyclical precipitation of halite-anhydrite couplets within the Pennsylvanian Paradox Formation, Paradox Basin, Utah

NASA Astrophysics Data System (ADS)

Marra, K. R.; Agena, W. F.; Dubiel, R. F.; Lee, M. W.; Pitman, J. K.

2012-12-01

The Pennsylvanian Paradox Formation (Hermosa Group) contains 33 documented evaporite cycles consisting of thick (6-240 m) halite successions interbedded with anhydrite, silty dolomite, and black shale. The evaporite deposits precipitated from marine brines under restricted circulation conditions in the Paradox Basin, a northwest-southeast trending asymmetrical trough formed adjacent to the Uncompahgre uplift, where periodic glacioeustatic sea-level fluctuations and intermittent meteoric water influxes altered salinity gradients. Each salt cycle contains rhythmically bedded halite-anhydrite couplets, in which anhedral to euhedral bottom-growth halite crystals are overlain by thin (mm-scale), subaqueously precipitated layers of anhydrite in the form of "snow-on-the-roof" texture. Discrete grains of sylvite, which are red due to hematite inclusions, locally occur as bands or aggregates throughout most salt packages. In order to delineate controls on high-frequency halite-anhydrite precipitation, the thickness of distinct couplets were measured in four salt cycles, two (Cycles 3 and 5) in the Cane Creek No.1 corehole and two (Cycles 5 and 13) in the Shafer No. 1 corehole. The cores were drilled approximately 8 km apart within the central portion of the basin near the crests of the Cane Creek and Shafer salt anticlines. The thickness of halite-anhydrite couplets ranges between 1-90 cm for all measured cycles, with the most commonly occurring thickness of approximately 3-4 cm. Despite the proximity of the two cores, the salt cycles in the Shafer No. 1 core are 12-15m thicker than in the Cane Creek No. 1 core, and individual couplets thicken within the middle (~20 m) of the salt section. In contrast, couplets thicken near the top of the halite bed in the Cane Creek No.1 core, which is most pronounced in Cycle 5. Locally disrupted and distorted laminae due to salt flowage, however, complicates some laminae measurements. The small-scale, cyclical pattern of halite-anhydrite couplets within the Paradox Formation may have resulted from annual water temperature (and corresponding calcium sulfate solubility) fluctuations or irregular influxes of meteoric waters due to storm or monsoon events. Interannual disturbances due to Spring and neap tides may have also played a role. The presence of sylvite may reflect a climatic overprint of arid conditions, which promoted eolian iron dispersal. Spectral analyses are being conducted on all measured salt cycles to discern bunching patterns in halite-anhydrite couplet thicknesses.

The Relationship of Core Strength and Activation and Performance on Three Functional Movement Screens.

PubMed

Johnson, Caleb D; Whitehead, Paul N; Pletcher, Erin R; Faherty, Mallory S; Lovalekar, Mita T; Eagle, Shawn R; Keenan, Karen A

2018-04-01

Johnson, CD, Whitehead, PN, Pletcher, ER, Faherty, MS, Lovalekar, MT, Eagle, SR, and Keenan, KA. The relationship of core strength and activation and performance on three functional movement screens. J Strength Cond Res 32(4): 1166-1173, 2018-Current measures of core stability used by clinicians and researchers suffer from several shortcomings. Three functional movement screens appear, at face-value, to be dependent on the ability to activate and control core musculature. These 3 screens may present a viable alternative to current measures of core stability. Thirty-nine subjects completed a deep squat, trunk stability push-up, and rotary stability screen. Scores on the 3 screens were summed to calculate a composite score (COMP). During the screens, muscle activity was collected to determine the length of time that the bilateral erector spinae, rectus abdominis, external oblique, and gluteus medius muscles were active. Strength was assessed for core muscles (trunk flexion and extension, trunk rotation, and hip abduction and adduction) and accessory muscles (knee flexion and extension and pectoralis major). Two ordinal logistic regression equations were calculated with COMP as the outcome variable, and: (a) core strength and accessory strength, (b) only core strength. The first model was significant in predicting COMP (p = 0.004) (Pearson's Chi-Square = 149.132, p = 0.435; Nagelkerke's R-Squared = 0.369). The second model was significant in predicting COMP (p = 0.001) (Pearson's Chi-Square = 148.837, p = 0.488; Nagelkerke's R-Squared = 0.362). The core muscles were found to be active for most screens, with percentages of "time active" for each muscle ranging from 54-86%. In conclusion, performance on the 3 screens is predicted by core strength, even when accounting for "accessory" strength variables. Furthermore, it seems the screens elicit wide-ranging activation of core muscles. Although more investigation is needed, these screens, collectively, seem to be a good assessment of core strength.

Sampling rare fluctuations of discrete-time Markov chains

NASA Astrophysics Data System (ADS)

Whitelam, Stephen

2018-03-01

We describe a simple method that can be used to sample the rare fluctuations of discrete-time Markov chains. We focus on the case of Markov chains with well-defined steady-state measures, and derive expressions for the large-deviation rate functions (and upper bounds on such functions) for dynamical quantities extensive in the length of the Markov chain. We illustrate the method using a series of simple examples, and use it to study the fluctuations of a lattice-based model of active matter that can undergo motility-induced phase separation.

Sampling rare fluctuations of discrete-time Markov chains.

PubMed

Whitelam, Stephen

2018-03-01

We describe a simple method that can be used to sample the rare fluctuations of discrete-time Markov chains. We focus on the case of Markov chains with well-defined steady-state measures, and derive expressions for the large-deviation rate functions (and upper bounds on such functions) for dynamical quantities extensive in the length of the Markov chain. We illustrate the method using a series of simple examples, and use it to study the fluctuations of a lattice-based model of active matter that can undergo motility-induced phase separation.

Diel-scale temporal dynamics recorded for bacterial groups in Namib Desert soil

PubMed Central

Gunnigle, Eoin; Frossard, Aline; Ramond, Jean-Baptiste; Guerrero, Leandro; Seely, Mary; Cowan, Don A.

2017-01-01

Microbes in hot desert soil partake in core ecosystem processes e.g., biogeochemical cycling of carbon. Nevertheless, there is still a fundamental lack of insights regarding short-term (i.e., over a 24-hour [diel] cycle) microbial responses to highly fluctuating microenvironmental parameters like temperature and humidity. To address this, we employed T-RFLP fingerprinting and 454 pyrosequencing of 16S rRNA-derived cDNA to characterize potentially active bacteria in Namib Desert soil over multiple diel cycles. Strikingly, we found that significant shifts in active bacterial groups could occur over a single 24-hour period. For instance, members of the predominant Actinobacteria phyla exhibited a significant reduction in relative activity from morning to night, whereas many Proteobacterial groups displayed an opposite trend. Contrary to our leading hypothesis, environmental parameters could only account for 10.5% of the recorded total variation. Potential biotic associations shown through co-occurrence networks indicated that non-random inter- and intra-phyla associations were ‘time-of-day-dependent’ which may constitute a key feature of this system. Notably, many cyanobacterial groups were positioned outside and/or between highly interconnected bacterial associations (modules); possibly acting as inter-module ‘hubs’ orchestrating interactions between important functional consortia. Overall, these results provide empirical evidence that bacterial communities in hot desert soils exhibit complex and diel-dependent inter-community associations. PMID:28071697

Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer's disease by evaluating protein interactions through molecular docking and dynamic simulations.

PubMed

Hassan, Mubashir; Shahzadi, Saba; Alashwal, Hany; Zaki, Nazar; Seo, Sung-Yum; Moustafa, Ahmed A

2018-05-22

Cas scaffolding protein family member 4 and protein tyrosine kinase 2 are signaling proteins, which are involved in neuritic plaques burden, neurofibrillary tangles, and disruption of synaptic connections in Alzheimer's disease. In the current study, a computational approach was employed to explore the active binding sites of Cas scaffolding protein family member 4 and protein tyrosine kinase 2 proteins and their significant role in the activation of downstream signaling pathways. Sequential and structural analyses were performed on Cas scaffolding protein family member 4 and protein tyrosine kinase 2 to identify their core active binding sites. Molecular docking servers were used to predict the common interacting residues in both Cas scaffolding protein family member 4 and protein tyrosine kinase 2 and their involvement in Alzheimer's disease-mediated pathways. Furthermore, the results from molecular dynamic simulation experiment show the stability of targeted proteins. In addition, the generated root mean square deviations and fluctuations, solvent-accessible surface area, and gyration graphs also depict their backbone stability and compactness, respectively. A better understanding of CAS and their interconnected protein signaling cascade may help provide a treatment for Alzheimer's disease. Further, Cas scaffolding protein family member 4 could be used as a novel target for the treatment of Alzheimer's disease by inhibiting the protein tyrosine kinase 2 pathway.

Diel-scale temporal dynamics recorded for bacterial groups in Namib Desert soil

NASA Astrophysics Data System (ADS)

Gunnigle, Eoin; Frossard, Aline; Ramond, Jean-Baptiste; Guerrero, Leandro; Seely, Mary; Cowan, Don A.

2017-01-01

Microbes in hot desert soil partake in core ecosystem processes e.g., biogeochemical cycling of carbon. Nevertheless, there is still a fundamental lack of insights regarding short-term (i.e., over a 24-hour [diel] cycle) microbial responses to highly fluctuating microenvironmental parameters like temperature and humidity. To address this, we employed T-RFLP fingerprinting and 454 pyrosequencing of 16S rRNA-derived cDNA to characterize potentially active bacteria in Namib Desert soil over multiple diel cycles. Strikingly, we found that significant shifts in active bacterial groups could occur over a single 24-hour period. For instance, members of the predominant Actinobacteria phyla exhibited a significant reduction in relative activity from morning to night, whereas many Proteobacterial groups displayed an opposite trend. Contrary to our leading hypothesis, environmental parameters could only account for 10.5% of the recorded total variation. Potential biotic associations shown through co-occurrence networks indicated that non-random inter- and intra-phyla associations were ‘time-of-day-dependent’ which may constitute a key feature of this system. Notably, many cyanobacterial groups were positioned outside and/or between highly interconnected bacterial associations (modules); possibly acting as inter-module ‘hubs’ orchestrating interactions between important functional consortia. Overall, these results provide empirical evidence that bacterial communities in hot desert soils exhibit complex and diel-dependent inter-community associations.

Ih current is necessary to maintain normal dopamine fluctuations and sleep consolidation in Drosophila.

PubMed

Gonzalo-Gomez, Alicia; Turiegano, Enrique; León, Yolanda; Molina, Isabel; Torroja, Laura; Canal, Inmaculada

2012-01-01

HCN channels are becoming pharmacological targets mainly in cardiac diseases. But apart from their well-known role in heart pacemaking, these channels are widely expressed in the nervous system where they contribute to the neuron firing pattern. Consequently, abolishing Ih current might have detrimental consequences in a big repertoire of behavioral traits. Several studies in mammals have identified the Ih current as an important determinant of the firing activity of dopaminergic neurons, and recent evidences link alterations in this current to various dopamine-related disorders. We used the model organism Drosophila melanogaster to investigate how lack of Ih current affects dopamine levels and the behavioral consequences in the sleep:activity pattern. Unlike mammals, in Drosophila there is only one gene encoding HCN channels. We generated a deficiency of the DmIh core gene region and measured, by HPLC, levels of dopamine. Our data demonstrate daily variations of dopamine in wild-type fly heads. Lack of Ih current dramatically alters dopamine pattern, but different mechanisms seem to operate during light and dark conditions. Behaviorally, DmIh mutant flies display alterations in the rest:activity pattern, and altered circadian rhythms. Our data strongly suggest that Ih current is necessary to prevent dopamine overproduction at dark, while light input allows cycling of dopamine in an Ih current dependent manner. Moreover, lack of Ih current results in behavioral defects that are consistent with altered dopamine levels.

Bringing global gyrokinetic turbulence simulations to the transport timescale using a multiscale approach

NASA Astrophysics Data System (ADS)

Parker, Jeffrey B.; LoDestro, Lynda L.; Told, Daniel; Merlo, Gabriele; Ricketson, Lee F.; Campos, Alejandro; Jenko, Frank; Hittinger, Jeffrey A. F.

2018-05-01

The vast separation dividing the characteristic times of energy confinement and turbulence in the core of toroidal plasmas makes first-principles prediction on long timescales extremely challenging. Here we report the demonstration of a multiple-timescale method that enables coupling global gyrokinetic simulations with a transport solver to calculate the evolution of the self-consistent temperature profile. This method, which exhibits resiliency to the intrinsic fluctuations arising in turbulence simulations, holds potential for integrating nonlocal gyrokinetic turbulence simulations into predictive, whole-device models.

Parasitic momentum flux in the tokamak core

DOE PAGES

Stoltzfus-Dueck, T.

2017-03-06

A geometrical correction to the E × B drift causes an outward flux of co-current momentum whenever electrostatic potential energy is transferred to ion parallel flows. The robust, fully nonlinear symmetry breaking follows from the free-energy flow in phase space and does not depend on any assumed linear eigenmode structure. The resulting rotation peaking is counter-current and scales as temperature over plasma current. Lastly, this peaking mechanism can only act when fluctuations are low-frequency enough to excite ion parallel flows, which may explain some recent experimental observations related to rotation reversals.