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Sample records for active duty members

  1. 2010 Workplace and Gender Relations Survey of Active Duty Members. Overview Report on Sexual Harassment

    DTIC Science & Technology

    2011-04-01

    2010 Workplace and Gender Relations Survey of Active Duty Members Overview Report on Sexual Harassment Additional copies of this report may...SURVEY OF ACTIVE DUTY MEMBERS: OVERVIEW REPORT ON SEXUAL HARASSMENT Lindsay M. Rock and Rachel N. Lipari Defense Manpower... ACTIVE DUTY MEMBERS: OVERVIEW REPORT ON SEXUAL HARASSMENT Executive Summary Background This report presents the results on issues related to

  2. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... certain active duty members of the Uniformed Services assigned to remote locations in the United States... active duty service member; and (ii) Pursuant to the assignment of such duty, resides at a location that... uniformed service concerned, based on a determination that such waiver is necessary to assure...

  3. 2006 Workplace and Gender Relations Survey of Active Duty Members: Tabulations of Responses. Volume 2: Coast Guard Members

    DTIC Science & Technology

    2008-07-01

    remarks about your appearance, body, or sexual activities ?................................................................................. 182 f...and Gender Relations Survey of Active Duty Members xviii DMDC d. Would people be able to get away with sexual harassment if it was reported...285 2006 Workplace and Gender Relations Survey of Active Duty Members DMDC xix SEXUAL ASSAULT TRAINING

  4. 2012 Workplace and Gender Relations Survey of Active Duty Members: Administration, Datasets and Codebook

    DTIC Science & Technology

    2013-11-04

    ABSTRACT This report documents the administration of the 2012 Workplace and Gender Relations Survey of Active Duty Members. 15. SUBJECT TERMS Sexual ... Active Duty Members Information Gathered on the Survey G-2 HOMESAFE To what extent do/would you feel safe from being sexually assaulted on your...of Active Duty Members Information Gathered on the Survey G-26 In an effort to prevent sexual assault, please indicate how well your unit

  5. 2012 Workplace and Gender Relations Survey of Active Duty Members. Survey Note and Briefing

    DTIC Science & Technology

    2013-03-15

    Exercises /Alerts Percent of Active Duty Members Who Experienced Unwanted Sexual Contact, by Gender WGRA 2012 Q35 Margins of error range from ±4% to ±12...harassment in the active duty force. This survey note and accompanying briefing (Appendix) provide information on the prevalence rates of sexual ...ELATIONS SURVEYSH R 2012 Workplace and Gender Relations Survey of Active Duty Members 2 Unwanted Sexual Contact 2006 2010 2012 Women: 6.8% Men

  6. 2012 Workplace and Gender Relations Survey of Active Duty Members: Nonresponse Bias Analysis Report

    DTIC Science & Technology

    2014-01-01

    the extent of nonresponse bias for the estimated rate of unwanted sexual contact (USC rate) in the active duty military. The level of nonresponse...of this research was to assess the extent of nonresponse bias for the estimated rate of unwanted sexual contact (USC rate)1 in the active duty...DMDC estimated that overall 1.9% (±0.45) of active duty military members had experienced unwanted sexual contact (USC) in the last 12 months. DMDC

  7. 2009 Workplace and Equal Opportunity Survey of Active Duty Members - Tabulation of Responses

    DTIC Science & Technology

    2010-03-30

    Opportunity Survey of Active Duty Members DMDC 469 Percentages 60f . Continued Percent Responding 1 2 3 Max ME Percentage Reporting Yes Officers 51...LIDYDLODEOH0XVWFLWHDWOHDVWWKH\\HDU DQGEH<HDUFRPSOLDQWHJ [[[[[[ 5(32577ɛ(6WDWHWKHW\\ SH RI

  8. 2005 Workplace and Equal Opportunity Survey of Active-Duty Members: Tabulation of Responses

    DTIC Science & Technology

    2007-06-01

    Not reportable 2005 Workplace and Equal Opportunity Survey of Active-Duty Members DMDC 505 Percentages 60f . Continued Percent Responding 1...5(32577ɛ(6WDWHWKHW\\ SH RIUHSRUWVXFKDV ILQDOWHFKQLFDOLQWHULPPHPRUDQGXPPDVWHU V WKHVLVSURJUHVV

  9. The Burden of Disability among Active Duty Air Force Members

    DTIC Science & Technology

    2006-09-01

    al., 2000). Injury Limited duty (days/injury) Fractures 103.2 Sprains 16.7 Other traumatic injuries 7.6 Tendinitis 7.0 Strains 3.0...iliotibial band syndrome (4.0% of subjects), ankle sprain (2.8%), and Achilles tendinitis /bursitis (2.8%) were the most frequently reported injuries; shin

  10. 2012 Workplace and Gender Relations Survey of Active Duty Members. Tabulations of Responses

    DTIC Science & Technology

    2013-04-01

    sexual activities ? ............................................................................................ 300 f. Made gestures or used body...Relations Survey of Active Duty Members DMDC xi h. Made unwanted attempts to establish a romantic sexual relationship with you despite your efforts...experiences of Crude/ Offensive Behavior, Unwanted Sexual Attention, or Sexual Coercion ........... 340 2012 Workplace and Gender Relations Survey of Active

  11. 2006 Gender Relations of Active-Duty Members

    DTIC Science & Technology

    2008-03-01

    37 15. Percent of Women Who Indicated Circumstances of Threats or Physical Force in Unwanted Sexual ...of Threats or Physical Force in Unwanted Sexual Contact, by Paygrade............................................................................42 17...18. Percent of Service Members Who Indicated Threats or Physical Force in Unwanted Sexual Contact, by Gender

  12. Risk Factors for Clinically Significant Intimate Partner Violence among Active-Duty Members

    ERIC Educational Resources Information Center

    Smith Slep, Amy M.; Foran, Heather M.; Heyman, Richard E.; Snarr, Jeffery D.

    2011-01-01

    Hypothesized risk factors for men's and women's clinically significant intimate partner violence (CS-IPV) from four ecological levels (i.e., individual, family, workplace, community) were tested in a representative sample of active-duty U.S. Air Force members (N = 42,744). When considered together, we expected only individual and family factors to…

  13. 2012 Workplace and Gender Relations Survey of Active Duty Members; Statistical Methodology Report

    DTIC Science & Technology

    2012-12-01

    Survey of Active Duty Members (2010 WGRA). The allocation was accomplished by means of the DMDC Sample Planning Tool, Version 2.1 ( Dever and Mason, 2003...This application is based on the method originally 10 developed by J. R. Chromy (1987), and is described in Mason, Wheeless, George, Dever ...Chair). Port Jefferson, NY: Author. Dever , J. A., and Mason, R. E. (2003). DMDC sample planning tool: Version 2.1. Arlington, VA: DMDC. Mason

  14. Development of a multilevel prevention program for improved relationship functioning in active duty military members.

    PubMed

    Heyman, Richard E; Smith Slep, Amy M; Sabathne, C; Eckardt Erlanger, Ann C; Hsu, Teresa T; Snyder, Douglas K; Balderrama-Durbin, Christina; Cigrang, Jeffrey A; Talcott, Gerald W; Tatum, JoLyn; Baker, Monty T; Cassidy, Daniel; Sonnek, Scott M

    2015-06-01

    The relationships and families of active duty (AD) service members have been tremendously strained by deployments and high operations' tempo. This study involves the first steps in developing a multilevel approach to preventing relationship problems that integrates universal, selective, and indicated prevention/intervention. Such an approach has tremendous empirical support for parenting problems, but no similar program exists for couple problems. We conducted two studies with U.S. Air Force Security Forces members. Study 1 elicited the target population's topics of highest interest. For almost all topics, 70% to 95% of participants who desired information reported being underserved by current prevention offerings (i.e., not receiving needed information). Using the top topics generated in Study 1, we developed prevention information/action planning sheets on 18 relationship issues. In Study 2, we had AD members who gave feedback on the form and content of the sheets. Overall, AD members believed that the sheets were moderately to very useful and were presented well, had pithy but comprehensive information and conveyed the content well. Results imply that a multilevel approach may be a useful complement to formal services in meeting underserved military members' needs and that further research and development of this dissemination vector for evidence-based information is warranted.

  15. Military Deployments and Mental Health Utilization Among Spouses of Active Duty Service Members.

    PubMed

    Leroux, Todd C; Kum, Hye-Chung; Dabney, Alan; Wells, Rebecca

    2016-10-01

    Since the onset of the wars in Iraq and Afghanistan attention has increased on the importance of mental health with military service members. An integral component, although far less studied, are the ties between mental health and military spouses. Military deployments place considerable stress on military families. This study analyzed the mental health utilization of military spouses of active duty service members assigned to an aircraft carrier between 2011 and 2014. A negative binomial generalized estimating equation was used to examine the rate of change in mental health utilization over time against various deployment phases. Associations emerged between select deployment phases (i.e., deployment 1, between deployments, deployment 2) with increases in mental health utilization ranging between 12% and 20% for military spouses. This study demonstrated, for military spouses, the in between deployment phase has associations with mental health utilization rates similar to actual deployed periods. As a result, military leaders should continue to monitor the well-being of their service members' families throughout all deployment phases.

  16. Sexual Assault and Sexual Harassment in the U.S. Military: Top-Line Estimates for Active-Duty Service Members from the 2014 RAND Military Workplace Study

    DTIC Science & Technology

    2014-01-01

    SEXUAL ASSAULT AND SEXUAL HARASSMENT IN THE U.S. MILITARY Top-Line Estimates for Active -Duty Service Members from the 2014 RAND Military Workplace...SUBTITLE Sexual Assault and Sexual Harassment in the U.S. Military: Top-Line Estimates for Active -Duty Service Members from the 2014 RAND Military Workplace...and Tables Figures 1. Estimated Percentage of Active -Duty Service Men and Women Who Experienced Unwanted Sexual Contact in the Past Year, as

  17. 2010 Workplace and Gender Relations Survey of Active Duty Members. Administration, Datasets, and Codebook

    DTIC Science & Technology

    2011-04-01

    ThrtFrc: Use physical force-Uned 672 STALKSHAU [55a] DidOffend: Sexually harass be-Uned 673 2010 Workplace and Gender Relations Survey of Active Duty...body, or sexual activities ? .......................................... Made gestures or used body language of a sexual nature that embarrassed or...slighted, or ignored you)?      e. Made offensive remarks about your appearance, body, or sexual activities

  18. Suicide Attempt Characteristics Among Veterans and Active-Duty Service Members Receiving Mental Health Services: A Pooled Data Analysis

    PubMed Central

    Villatte, Jennifer L.; O’Connor, Stephen S.; Leitner, Rebecca; Kerbrat, Amanda H.; Johnson, Lora L.; Gutierrez, Peter M.

    2015-01-01

    Past suicidal behaviors are among the strongest and most consistent predictors of eventual suicide and may be particularly salient in military suicide. The current study compared characteristics of suicide attempts in veterans (N = 746) and active-duty service members (N = 1,013) receiving treatment for acute suicide risk. Baseline data from six randomized controlled trials were pooled and analyzed using robust regression. Service members had greater odds of having attempted suicide relative to veterans, though there were no differences in number of attempts made. Service members also had higher rates of premilitary suicide attempts and nonsuicidal self-injury (NSSI). Veterans disproportionately attempted suicide by means of overdose. In veterans, combat deployment was associated with lower odds of lifetime suicide attempt, while history of NSSI was associated with greater attempt odds. Neither was significantly associated with lifetime suicide attempt in service members. Implications for suicide assessment and treatment are discussed. PMID:26740909

  19. April 2006 Status of Forces Survey of Active-Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2006-08-01

    scale 998 CHLCOPEU* [60e] Import:fam mbrs deal w/deploy-Uned 777 CHLCOPF 60f . [ 60f ] Import:no relocations/school chang 84 CHLCOPFR* Briefing of...CHLCOPF:collapse scale 999 CHLCOPFU* [ 60f ] Import:no relocations/school-Uned 778 SOFA0604 Active Duty April 2006 Alphabetical Table of Contents...deployment 83 CHLCOPF 60f . [ 60f ] Import:no relocations/school chang 84 CHLCOPG 60g. [60g] Import:limit exposure of news cove 85 CHLCOPH 60h. [60h

  20. Political Activities by Members of the Armed Forces on Active Duty

    DTIC Science & Technology

    1990-06-15

    an election day. 13. Solicit or otherwise engage in fundraising activities in Federal offices or facilities, including military reservations, for a...actively promote, political dinners and similar fundraising events. 18. Attend partisan political events as an official representative of the Armed Forces

  1. Development and Testing of Virtual Reality Exposure Therapy for Post-Traumatic Stress Disorder in Active Duty Service Members Who Served in Iraq and Afghanistan

    DTIC Science & Technology

    2012-06-01

    Exposure Therapy for Post-Traumatic Stress Disorder in Active Duty Service Members Who Served in Iraq and Afghanistan CDR Robert N. McLay, MC USNR...reality exposure therapy (VRET) to active duty service members diagnosed with combat post-traumatic stress disorder (PTSD). Forty-two service members with...reduction in PTSD symptoms and no longer met DSM-IV criteria for PTSD at post treatment. Average PSTD scores decreased by 50.4%, depression scores by 46.6

  2. March 2003 Status of Forces Survey of Active-Duty Members: Tabulations of Responses

    DTIC Science & Technology

    2003-07-01

    completed quality control for the volume. DMDC iii Table of Contents Page Introduction to the Survey...20 d. The quality of your coworkers ...................................................................22 e. The quality of your supervisor...304 86. Suppose when you first arrived at your current duty station that the quality of both on-base housing and the type of

  3. 2013 Workplace and Equal Opportunity Survey of Active Duty Members: Overview Report

    DTIC Science & Technology

    2014-10-01

    the military have changed over time. The findings provide general perceptions of whether Service members thought that race relations have improved ...received poorer treatment than you deserved from a military health care provider. • You were harassed by armed forces police. 1.9 1.3 3.0 1.9 1.3 0.9 0 20...24% 33% 15% 35% 31% NR 36% 38% 28% At a military non-work location (for example, gym , quarters/housing, exchange/commissary, bowling alley)? 21

  4. 2013 Workplace and Equal Opportunity Survey of Active Duty Members: Tabulations Responses

    DTIC Science & Technology

    2014-03-01

    214  e.  Displayed tattoos or wore distinctive clothes which were racist? ........ 216  f.  Did not include you in social activities...and/or contractors (in your workplace or on or off your installation/ship)... e. Displayed tattoos or wore distinctive clothes which were racist...contractors (in your workplace or on or off your installation/ship)... e. Displayed tattoos or wore distinctive clothes which were racist? Percent

  5. Supporting School Success for Homeless Children of Veterans and Active Duty Military Members. Best Practices in Interagency Collaboration

    ERIC Educational Resources Information Center

    National Center for Homeless Education at SERVE, 2011

    2011-01-01

    This brief is designed for local staff of the Department of Veterans Affairs (VA), state McKinney-Vento coordinators and school district McKinney-Vento liaisons, educators, and other providers of services to active members of the military and veterans, and their children. It provides basic information to assist homeless children of veterans or…

  6. Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of Aβ40 and lower ratios of Aβ42/40

    PubMed Central

    Lejbman, Natasha; Olivera, Anlys; Heinzelmann, Morgan; Feng, Rebekah; Yun, Sijung; Kim, Hyung-Suk; Gill, Jessica

    2016-01-01

    Abstract Primary objective: Excessive accumulation of amyloid beta (Aβ) and tau have been observed in older individuals with chronic neurological symptoms related to a traumatic brain injury (TBI), yet little is known about the possible role of Aβ in younger active duty service members following a TBI. The purpose of the study was to determine if Aβ 40 or 42 related to sustaining a TBI or to chronic neurological symptoms in a young cohort of military personnel. Research design: This was a cross-sectional study of active duty service members who reported sustaining a TBI and provided self-report of neurological and psychological symptoms and provided blood. Methods and procedures: An ultrasensitive single-molecule enzyme-linked immunosorbent assay was used to compare concentrations of Aβ in active duty service members with (TBI+; n = 53) and without (TBI–; n = 18) a history of TBI. Self-report and medical history were used to measure TBI occurrence and approximate the number of total TBIs and the severity of TBIs sustained during deployment. Main outcomes and results: This study reports that TBI is associated with higher concentrations of Aβ40 (F 1,68 = 6.948, p = 0.009) and a lower ratio of Aβ42/Aβ40 (F 1,62 = 5.671, p = 0.020). These differences remained significant after controlling for co-morbid symptoms of post-traumatic stress disorder and depression. Conclusions: These findings suggest that alterations in Aβ relate to TBIs and may contribute to chronic neurological symptoms. PMID:27834544

  7. The psychometric properties of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) in a clinical sample of active duty military service members.

    PubMed

    Mitchell, Damon; Francis, Joseph P; Tafrate, Raymond Chip

    2005-11-01

    The increasing prominence of the construct of readiness to change in the field of substance abuse treatment has led to the development of instruments designed to assess the construct. We examined the psychometric properties of one such instrument, the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES), in a sample of treatment-seeking, active duty, U.S. military service members diagnosed with alcohol and/or drug dependence. A principal components analysis of the items was consistent with the tridimensional structure of the SOCRATES found among treatment-seeking civilians but resulted in a 14-item scale, as opposed to the 19-item version found for civilians. Normative data, in the form of means and decile rankings for the SOCRATES subscales, for substance-dependent military patients are provided to complement those available for civilian patients. Future research should examine the concurrent and predictive validity of the scale.

  8. TRICARE: changes included in the National Defense Authorization Act for Fiscal Year 2010; enhancement of transitional dental care for members of the Reserve Component on active duty for more than 30 days in support of a contingency operation. Final rule.

    PubMed

    2011-12-28

    The Department is publishing this final rule to implement section 703 of the National Defense Authorization Act for Fiscal Year 2010 (NDAA for FY10). Specifically, that legislation amends the transitional health care dental benefits for Reserve Component members on active duty for more than 30 days in support of a contingency operation. The legislation entitles these Reserve Component members to dental care in the same manner as a member of the uniformed services on active duty for more than 30 days, thus providing care to the Reserve member in both military dental treatment facilities and authorized private sector dental care. This final rule does not eliminate any medical or dental care that is currently covered as transitional health care for the member.

  9. Development and testing of virtual reality exposure therapy for post-traumatic stress disorder in active duty service members who served in Iraq and Afghanistan.

    PubMed

    McLay, Robert N; Graap, Kenneth; Spira, James; Perlman, Karen; Johnston, Scott; Rothbaum, Barbara O; Difede, JoAnn; Deal, William; Oliver, David; Baird, Alicia; Bordnick, Patrick S; Spitalnick, Josh; Pyne, Jeffrey M; Rizzo, Albert

    2012-06-01

    This study was an open-label, single-group, treatment-development project aimed at developing and testing a method for applying virtual reality exposure therapy (VRET) to active duty service members diagnosed with combat post-traumatic stress disorder (PTSD). Forty-two service members with PTSD were enrolled, and 20 participants completed treatment. The PTSD Checklist-Military version, Patient Health Questionnaire-9 for depression, and the Beck Anxiety Inventory were used as outcome measures. Of those who completed post-treatment assessment, 75% had experienced at least a 50% reduction in PTSD symptoms and no longer met DSM-IV criteria for PTSD at post treatment. Average PSTD scores decreased by 50.4%, depression scores by 46.6%, and anxiety scores by 36%. Intention-to-treat analyses showed that statistically significant improvements in PTSD, depression, and anxiety occurred over the course of treatment and were maintained at follow up. There were no adverse events associated with VRET treatment. This study provides preliminary support for the use of VRET in combat-related PTSD. Further study will be needed to determine the wider utility of the method and to determine if it offers advantages over other established PTSD treatment modalities.

  10. Impact of Transcendental Meditation on Psychotropic Medication Use Among Active Duty Military Service Members With Anxiety and PTSD.

    PubMed

    Barnes, Vernon A; Monto, Andrea; Williams, Jennifer J; Rigg, John L

    2016-01-01

    The purpose of the study was to determine whether the regular practice of Transcendental Meditation (TM) decreased the need for psychotropic medications required for anxiety and post-traumatic stress disorder (PTSD) management and increased psychological wellbeing. The sample included 74 military Service Members with documented PTSD or anxiety disorder not otherwise specified (ADNOS), 37 that practiced TM and 37 that did not. At 1 month, 83.7% of the TM group stabilized, decreased, or ceased medications and 10.8% increased medication dosage; compared with 59.4% of controls that showed stabilizations, decreases, or cessations; and 40.5% that increased medications (p < 0.03). A similar pattern was observed after 2 (p < 0.27), 3 (p < 0.002), and 6 months (p < 0.34). Notably, there was a 20.5% difference between groups in severity of psychological symptoms after 6 months, that is, the control group experienced an increase in symptom severity compared with the group practicing TM. These findings provide insight into the benefits of TM as a viable treatment modality in military treatment facilities for reducing PTSD and ADNOS psychological symptoms and associated medication use.

  11. The Impact of Environment and Occupation on the Health and Safety of Active Duty Air Force Members - Database Development

    DTIC Science & Technology

    2014-04-01

    abuse, and physical altercations), high-risk sexual behavior (e.g., unprotected sexual intercourse), and physical health issues, such as high blood... sexual activity questions (section 12- reproductive ) PHA Sexually transmitted disease Sponsor ID (SSN), dependent status, DOB, sponsor pay grade...based on encounters and responses. The requested Health Assessment data consisted of specific information relating to tobacco, alcohol, and sexual

  12. Voxel-wise resting-state MEG source magnitude imaging study reveals neurocircuitry abnormality in active-duty service members and veterans with PTSD

    PubMed Central

    Huang, Ming-Xiong; Yurgil, Kate A.; Robb, Ashley; Angeles, Annemarie; Diwakar, Mithun; Risbrough, Victoria B.; Nichols, Sharon L.; McLay, Robert; Theilmann, Rebecca J.; Song, Tao; Huang, Charles W.; Lee, Roland R.; Baker, Dewleen G.

    2014-01-01

    Post-traumatic stress disorder (PTSD) is a leading cause of sustained impairment, distress, and poor quality of life in military personnel, veterans, and civilians. Indirect functional neuroimaging studies using PET or fMRI with fear-related stimuli support a PTSD neurocircuitry model that includes amygdala, hippocampus, and ventromedial prefrontal cortex (vmPFC). However, it is not clear if this model can fully account for PTSD abnormalities detected directly by electromagnetic-based source imaging techniques in resting-state. The present study examined resting-state magnetoencephalography (MEG) signals in 25 active-duty service members and veterans with PTSD and 30 healthy volunteers. In contrast to the healthy volunteers, individuals with PTSD showed: 1) hyperactivity from amygdala, hippocampus, posterolateral orbitofrontal cortex (OFC), dorsomedial prefrontal cortex (dmPFC), and insular cortex in high-frequency (i.e., beta, gamma, and high-gamma) bands; 2) hypoactivity from vmPFC, Frontal Pole (FP), and dorsolateral prefrontal cortex (dlPFC) in high-frequency bands; 3) extensive hypoactivity from dlPFC, FP, anterior temporal lobes, precuneous cortex, and sensorimotor cortex in alpha and low-frequency bands; and 4) in individuals with PTSD, MEG activity in the left amygdala and posterolateral OFC correlated positively with PTSD symptom scores, whereas MEG activity in vmPFC and precuneous correlated negatively with symptom score. The present study showed that MEG source imaging technique revealed new abnormalities in the resting-state electromagnetic signals from the PTSD neurocircuitry. Particularly, posterolateral OFC and precuneous may play important roles in the PTSD neurocircuitry model. PMID:25180160

  13. 75 FR 55851 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ...The FAA is proposing to amend its existing flight, duty and rest regulations applicable to certificate holders and their flightcrew members. The proposal recognizes the growing similarities between the types of operations and the universality of factors that lead to fatigue in most individuals. Fatigue threatens aviation safety because it increases the risk of pilot error that could lead to an......

  14. The Impact of Environment and Occupation on the Health and Safety of Active Duty Air Force Members: Database Development and De-Identification.

    PubMed

    Erich, Roger; Eaton, Melinda; Mayes, Ryan; Pierce, Lamar; Knight, Andrew; Genovesi, Paul; Escobar, James; Mychalczuk, George; Selent, Monica

    2016-08-01

    Preparing data for medical research can be challenging, detail oriented, and time consuming. Transcription errors, missing or nonsensical data, and records not applicable to the study population may hamper progress and, if unaddressed, can lead to erroneous conclusions. In addition, study data may be housed in multiple disparate databases and complex formats. Merging methods may be incomplete to obtain temporally synchronized data elements. We created a comprehensive database to explore the general hypothesis that environmental and occupational factors influence health outcomes and risk-taking behavior among active duty Air Force personnel. Several databases containing demographics, medical records, health survey responses, and safety incident reports were cleaned, validated, and linked to form a comprehensive, relational database. The final step involved removing and transforming personally identifiable information to form a Health Insurance Portability and Accountability Act compliant limited database. Initial data consisted of over 62.8 million records containing 221 variables. When completed, approximately 23.9 million clean and valid records with 214 variables remained. With a clean, robust database, future analysis aims to identify high-risk career fields for targeted interventions or uncover potential protective factors in low-risk career fields.

  15. Civilian Health and Medical Program of the Uniformed Services (CHAMPUS); TRICARE uniform health maintenance organization (HMO) benefit--Prime enrollment fee exemption for survivors of active duty deceased sponsors and medically retired uniformed services members and their dependents. Final rule.

    PubMed

    2014-09-30

    This final rule creates an exception to the usual rule that TRICARE Prime enrollment fees are uniform for all retirees and their dependents and responds to public comments received to the proposed rule published in the Federal Register on June 7, 2013. Survivors of Active Duty Deceased Sponsors and Medically Retired Uniformed Services Members and their Dependents are part of the retiree group under TRICARE rules. In acknowledgment and appreciation of the sacrifices of these two beneficiary categories, the Secretary of Defense has elected to exercise his authority under the United States Code to exempt Active Duty Deceased Sponsors and Medically Retired Uniformed Services Members and their Dependents enrolled in TRICARE Prime from paying future increases to the TRICARE Prime annual enrollment fees. The Prime beneficiaries in these categories have made significant sacrifices for our country and are entitled to special recognition and benefits for their sacrifices. Therefore, the beneficiaries in these two TRICARE beneficiary categories who enrolled in TRICARE Prime prior to 10/1/2013, and those since that date, will have their annual enrollment fee frozen at the appropriate fiscal year rate: FY2011 rate $230 per single or $460 per family, FY2012 rate $260 or $520, FY2013 rate $269.38 or $538.56, or the FY2014 rate $273.84 or $547.68. The future beneficiaries added to these categories will have their fee frozen at the rate in effect at the time they are classified in either category and enroll in TRICARE Prime or, if not enrolling, at the rate in effect at the time of enrollment. The fee remains frozen as long as at least one family member remains enrolled in TRICARE Prime and there is not a break in enrollment. The fee charged for the dependent(s) of a Medically Retired Uniformed Services Member would not change if the dependent(s) was later re-classified a Survivor.

  16. Increasing Marital Satisfaction as a Resilience Factor among Active Duty Members and Veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF)

    ERIC Educational Resources Information Center

    Ponder, Warren N.; Aguirre, Regina T. P.; Smith-Osborne, Alexa; Granvold, Donald K.

    2012-01-01

    Supportive relationships are protective against a number of prevalent health risks among military populations, including post-traumatic stress disorder. Increasing marital satisfaction and strengthening that relationship is an important avenue for maintaining health among returning service members and their families. The current study builds upon…

  17. 77 FR 329 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    .... Definitions C. Fitness for Duty D. Fatigue Education and Training E. Fatigue Risk Management System F. Flight... are currently statutorily-required to annually provide, as part of their Fatigue Risk Management Plan... regulations for the ease and convenience of the regulated parties and the FAA. 3. Fatigue Risk...

  18. Unintended Pregnancy and Contraception Among Active Duty Servicewomen and Veterans

    PubMed Central

    Goyal, Vinita; Borrero, Sonya; Schwarz, Eleanor Bimla

    2012-01-01

    The number of women of childbearing age who are active duty service members or veterans of the U.S. military is increasing. These women may seek reproductive health care at medical facilities operated by the military, in the civilian sector or through the Department of Veterans Affairs. This article reviews the current data on unintended pregnancy and prevalence of and barriers to contraceptive use among active duty and veteran women. Active duty servicewomen have high rates of unintended pregnancy and low contraceptive use which may be due to official prohibition of sexual activity in the military, logistic difficulties faced by deployed women and limited patient and provider knowledge of available contraceptives. In comparison, little is known about rates of unintended pregnancy and contraceptive use among women veterans. Based on this review, research recommendations to address these issues are provided. PMID:22200252

  19. Mental Health Concerns: Veterans & Active Duty

    MedlinePlus

    ... through My Health e Vet , the VA’s online personal health record. This site for veterans, active duty ... their families provides access to health records, a personal health journal, online VA prescription refill information and ...

  20. 12 CFR 1022.121 - Active duty alerts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Active duty alerts. 1022.121 Section 1022.121 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION FAIR CREDIT REPORTING (REGULATION V) Duties of Consumer Reporting Agencies Regarding Identity Theft § 1022.121 Active duty alerts. (a) Duration....

  1. 12 CFR 1022.121 - Active duty alerts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Active duty alerts. 1022.121 Section 1022.121 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION FAIR CREDIT REPORTING (REGULATION V) Duties of Consumer Reporting Agencies Regarding Identity Theft § 1022.121 Active duty alerts. (a) Duration....

  2. 12 CFR 1022.121 - Active duty alerts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Active duty alerts. 1022.121 Section 1022.121 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION FAIR CREDIT REPORTING (REGULATION V) Duties of Consumer Reporting Agencies Regarding Identity Theft § 1022.121 Active duty alerts. (a) Duration....

  3. A Case of Superior Mesenteric Artery Syndrome in a Healthy Active Duty Marine.

    PubMed

    Thota, Darshan; Portouw, Steven J; Bruner, David I

    2015-10-01

    Superior mesenteric artery (SMA) syndrome is an uncommon disorder that can lead to small bowel obstructions or perforations. Typical populations include young females with anorexia. However, there have been a few reports of healthy males with acute vomiting reported to have SMA syndrome. Our case report highlights an active duty Marine who developed SMA syndrome and the importance of recognizing this disease given the severity in delay of diagnosis in population of young healthy active duty members.

  4. Disaster Preparedness Among Active Duty Navy, Retirees, Veterans, and Dependents

    PubMed Central

    Annis, Heather; Jacoby, Irving; DeMers, Gerard

    2016-01-01

    Background With the increase in natural and manmade disasters, preparedness remains a vital area of concern. Despite attempts by government and non-government agencies to stress the importance of preparedness, national levels of preparedness remain unacceptably low. A goal of commands and installations is to ensure that US Navy beneficiaries are well prepared for disasters. This is especially critical in active service members to meet mission readiness requirements in crisis settings. Objective To evaluate active duty personnel, dependents, veterans, and retirees regarding disaster preparedness status. Methods The authors conducted an anonymous 29-question survey for US Navy active duty, dependents, veterans and retirees of the Greater San Diego Region evaluating actual basic disaster readiness as determined by FEMA standards of 3-day minimum supply of emergency stores and equipment. Descriptive statistics and regression analysis were used to analyze data. Results 1150 surveys were returned and analyzed. 983 were sufficiently complete for logistic regression analysis with 394 responding “Yes” to having a 72-hour disaster kit (40.1%) while 589 had “No” as a response (59.9%). Conclusion The surveyed population is no more prepared than the general public though surveyed beneficiaries overall are at upper range of preparedness. Lower income and levels of education were associated with lack of preparedness, whereas training in disaster preparedness or having been affected by disasters increased the likelihood of being adequately prepared. Unlike results seen in the general public, those with chronic healthcare needs in our surveyed population were more, rather than less likely to be prepared and those with minor children were less likely, rather than more likely to be prepared. Duty status was assessed and only veterans were significantly more likely than most to be prepared. PMID:26903142

  5. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  6. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  7. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  8. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  9. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  10. Chronic pain management in the active-duty military

    NASA Astrophysics Data System (ADS)

    Jamison, David; Cohen, Steven P.

    2012-06-01

    As in the general population, chronic pain is a prevalent and burdensome affliction in active-duty military personnel. Painful conditions in military members can be categorized broadly in terms of whether they arise directly from combat injuries (gunshot, fragmentation wound, blast impact) or whether they result from non-combat injuries (sprains, herniated discs, motor vehicle accidents). Both combat-related and non-combat-related causes of pain can further be classified as either acute or chronic. Here we discuss the state of pain management as it relates to the military population in both deployed and non-deployed settings. The term non-battle injury (NBI) is commonly used to refer to those conditions not directly associated with the combat actions of war. In the history of warfare, NBI have far outstripped battle-related injuries in terms not only of morbidity, but also mortality. It was not until improvements in health care and field medicine were applied in World War I that battle-related deaths finally outnumbered those attributed to disease and pestilence. However, NBI have been the leading cause of morbidity and hospital admission in every major conflict since the Korean War. Pain remains a leading cause of presentation to military medical facilities, both in and out of theater. The absence of pain services is associated with a low return-to-duty rate among the deployed population. The most common pain complaints involve the low-back and neck, and studies have suggested that earlier treatment is associated with more significant improvement and a higher return to duty rate. It is recognized that military medicine is often at the forefront of medical innovation, and that many fields of medicine have reaped benefit from the conduct of war.

  11. Health promotion in active-duty military women with children.

    PubMed

    Agazio, Janice G; Ephraim, Paula M; Flaherty, Norma B; Gurney, Cynthia A

    2002-01-01

    The purpose of this study was to determine the extent to which selected demographic characteristics, definition of health, perceived health status, perceived self-efficacy, and resources are related to the health promoting behaviors of active-duty women with children and to describe qualitatively the experience of being an active-duty mother. Grounded in Pender's (1996) Health Promotion Model, this study used methodological triangulation to test a hypothesized model. A sample of 141 active-duty women with children using military health services participated. Resource availability and commitment were key components of being successful at balancing home and work demands.

  12. Prospective post-traumatic stress disorder symptom trajectories in active duty and separated military personnel.

    PubMed

    Porter, Ben; Bonanno, George A; Frasco, Melissa A; Dursa, Erin K; Boyko, Edward J

    2017-06-01

    Post-traumatic stress disorder (PTSD) is a serious mental illness that affects current and former military service members at a disproportionately higher rate than the civilian population. Prior studies have shown that PTSD symptoms follow multiple trajectories in civilians and military personnel. The current study examines whether the trajectories of PTSD symptoms of veterans separated from the military are similar to continuously serving military personnel. The Millennium Cohort Study is a population-based study of military service members that commenced in 2001 with follow-up assessments occurring approximately every 3 years thereafter. PTSD symptoms were assessed at each time point using the PTSD Checklist. Latent growth mixture modeling was used to compare PTSD symptom trajectories between personnel who separated (veterans; n = 5292) and personnel who remained in military service (active duty; n = 16,788). Four distinct classes (resilient, delayed-onset, improving, and elevated-recovering) described PTSD symptoms trajectories in both veterans and active duty personnel. Trajectory shapes were qualitatively similar between active duty and veterans. However, within the resilient, improving, and elevated recovering classes, the shapes were statistically different. Although the low-symptom class was the most common in both groups (veterans: 82%; active duty: 87%), veterans were more likely to be classified in the other three classes (in all cases, p < 0.01). The shape of each trajectory was highly similar between the two groups despite differences in military and civilian life.

  13. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... include participation in a military reserve or the National Guard unless the borrower is called to active... 7 Agriculture 15 2010-01-01 2010-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military...

  14. Prevalence of Perceived Stress and Mental Health Indicators Among Reserve-Component and Active-Duty Military Personnel

    PubMed Central

    Lane, Marian E.; Hourani, Laurel L.; Bray, Robert M.; Williams, Jason

    2012-01-01

    Objectives. We examined stress levels and other indicators of mental health in reservists and active-duty military personnel by deployment status. Methods. We used data from the Department of Defense Health-Related Behaviors surveys, which collect comprehensive, population-based data for reserve and active-duty forces. Data were collected from 18 342 reservists and 16 146 active-duty personnel. Results. Overall, with adjustment for sociodemographic and service differences, reservists reported similar or less work and family stress, depression, and anxiety symptoms than did active-duty personnel. However, reservists who had been deployed reported higher rates of suicidal ideation and attempts than did active-duty personnel who had been deployed and higher rates of post-traumatic stress disorder symptomatology than did any active-duty personnel and reservists who had not been deployed. The highest rates of suicidal ideation and attempts were among reservists who had served in theaters other than Iraq and Afghanistan. Conclusions. Our results suggest that deployment has a greater impact on reservists than on active-duty members, thus highlighting the urgent need for services addressing reservists’ unique postdeployment mental health issues. Also, deployment to any theater, not only Iraq or Afghanistan, represents unique threats to all service members’ mental well-being. PMID:22571709

  15. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Active military duty. 3550.158 Section 3550.158 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military...

  16. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Active military duty. 3550.158 Section 3550.158 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military...

  17. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Active military duty. 3550.158 Section 3550.158 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military...

  18. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Active military duty. 3550.158 Section 3550.158 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military...

  19. An Analysis of Generational Differences Among Active Duty Members

    DTIC Science & Technology

    2004-03-01

    political , and racial lenses. Therefore, it may be difficult to point to an absolute generational group that is defined by a set of shared...group as those born between 1965 and 1978. Finally, the newest generation born after 1979, the Millennials , often given the label Generation Y or Echo...computer technology. Howe and Strauss (2000) define the Millennials as the generation born between 1982 and 2000. The Millennial Cohort, as defined by

  20. 1999 Survey of Active Duty Personnel: Statistical Methodology Report

    DTIC Science & Technology

    2000-09-01

    6218 Ask for report by ADA 386 288 DMDC Report No. 2000-010 September 2000 1999 SURVEY OF ACTIVE DUTY PERSONNEL: STATISTICAL METHODOLOGY REPORT...STATISTICAL METHODOLOGY REPORT Executive Summary This report describes the sampling design, sample selection, estimation procedures, and the missing data

  1. Changes in Career Intent during Initial Tour of Active Duty.

    ERIC Educational Resources Information Center

    Shenk, Faye

    The study was designed to determine the predictability of an Air Force officer's career decision and to evaluate relationships between career decision and various demographic, environmental, and attitudinal factors. Information on this group was compiled for the period before commissioning and through five years of active duty. The report presents…

  2. Active Member Design, Modeling, and Verification

    NASA Technical Reports Server (NTRS)

    Umland, Jeffrey W.; Webster, Mark; John, Bruce

    1993-01-01

    The design and development of active members intended for use in structural control applications is presented. The use of three different solid state actuation materials, namely, piezoelectric, electrostictive, and magnetostrictive, is discussed. Test data is given in order to illustrate the actuator and device characteristics and performance.

  3. House Divided: The Splitting of Active Duty Civil Affairs Forces

    DTIC Science & Technology

    2009-12-01

    training of Active Duty Civil Affairs. This will allow the reader to become familiar with the Active branch as a whole and show the different...readers are extremely familiar with the large-scale environment given the nightly news coverage, but the small-scale environment is decidedly different...apparatus and are familiar with operating in conjunction with embassies and country teams. While conventional forces also have their own intelligence

  4. Prevalence of Intimate Partner Violence, Stalking, and Sexual Violence Among Active Duty Women and Wives of Active Duty Men - Comparisons with Women in the U.S. General Population, 2010

    DTIC Science & Technology

    2013-03-01

    Prevalence of Intimate Partner Violence, Stalking, and Sexual Violence Among Active Duty Women and Wives of Active Duty Men—Comparisons with Women...Technical Report Prevalence of Intimate Partner Violence, Sexual Violence, and Stalking among Active Duty Women and Wives of Active Duty Men— Comparisons...the General U.S. Population, Active Duty Women, and Wives of Active Duty Men by Type of Perpetrator — NISVS 2010 Table 3 Prevalence of Contact Sexual

  5. Virtual reality exposure therapy for active duty soldiers.

    PubMed

    Reger, Greg M; Gahm, Gregory A

    2008-08-01

    Virtual reality exposure (VRE) therapy is a promising treatment for a variety of anxiety disorders and has recently been extended to the treatment of posttraumatic stress disorder (PTSD). In this article, the authors briefly review the rationale for VRE and its key processes. They illustrate the treatment with an active-duty Army soldier diagnosed with combat-related PTSD. Six sessions of VRE were provided using an immersive simulation of a military convoy in Iraq. Self-reported PTSD symptoms and psychological distress were reduced at posttreatment relative to pretreatment reports, as assessed by the PTSD Checklist-Military Version and the Behavior and Symptom Identification Scale-24. The case outcomes parallel those reported in the research with other disorders and suggest the applicability of VRE in treating active duty soldiers with combat-related PTSD.

  6. Returning service members to duty following mild traumatic brain injury: exploring the use of dual-task and multitask assessment methods.

    PubMed

    Scherer, Matthew R; Weightman, Margaret M; Radomski, Mary V; Davidson, Leslie F; McCulloch, Karen L

    2013-09-01

    Within the last decade, more than 220,000 service members have sustained traumatic brain injury (TBI) in support of military operations in Iraq and Afghanistan. Mild TBI may result in subtle cognitive and sensorimotor deficits that adversely affect warfighter performance, creating significant challenges for service members, commanders, and clinicians. In recent conflicts, physical therapists and occupational therapists have played an important role in evaluating service member readiness to return to duty (RTD), incorporating research and best practices from the sports concussion literature. Because premorbid (baseline) performance metrics are not typically available for deployed service members as for athletes, clinicians commonly determine duty readiness based upon the absence of postconcussive symptoms and return to "normal" performance on clinical assessments not yet validated in the military population. Although practices described in the sports concussion literature guide "return-to-play" determinations, resolution of symptoms or improvement of isolated impairments may be inadequate to predict readiness in a military operational environment. Existing clinical metrics informing RTD decision making are limited because they fail to emphasize functional, warrior task demands and they lack versatility to assess the effects of comorbid deficits. Recently, a number of complex task-oriented RTD approaches have emerged from Department of Defense laboratory and clinical settings to address this gap. Immersive virtual reality environments, field-based scenario-driven assessment programs, and militarized dual-task and multitask-based approaches have all been proposed for the evaluation of sensorimotor and cognitive function following TBI. There remains a need for clinically feasible assessment methods that can be used to verify functional performance and operational competence in a variety of practice settings. Complex and ecologically valid assessment techniques

  7. Intimate partner violence among military veterans and active duty servicemen.

    PubMed

    Marshall, Amy D; Panuzio, Jillian; Taft, Casey T

    2005-11-01

    Intimate partner violence (IPV) is a serious public health problem that has received increased attention in the military. We review existing literature regarding prevalence, consequences, correlates, and treatment of IPV perpetration among military veterans and active duty servicemen. Rates of IPV across these military populations range from 13.5% to 58%, with considerably lower rates obtained among samples not selected on the basis of psychopathology. For both military veterans and active duty servicemen, IPV results in significant victim injury and negative child outcomes, and problematic substance use, depression, and antisocial characteristics represent psychiatric correlates of IPV perpetration. For veterans, posttraumatic stress disorder also is an important correlate that largely accounts for the relationship between combat exposure and IPV perpetration. Additional correlates include military service factors, relationship adjustment, childhood trauma, and demographic factors. The only experimentally controlled IPV treatment study indicates that standard treatments are ineffective for active duty servicemen. Further research is needed to advance the development of etiological models of IPV among military populations, to determine whether such models necessarily differ from those developed among civilians, and to rigorously test IPV interventions tailored to the specific characteristics of these individuals.

  8. 2011 Health Related Behaviors Survey of Active Duty Military Personnel

    DTIC Science & Technology

    2013-02-01

    with about 1.4% reporting illicit drug, synthetic cannabis , or inhalant use in the past 12 months.1  About one-quarter (24.9%) of active duty personnel...drug use began by asking about the use of a variety of illicit drugs such as marijuana, cocaine, and heroin. Two substances, synthetic cannabis and...of any “illicit” drug use. Since survey administration in 2011, many of the compounds found in synthetic cannabis have been classified by the military

  9. Design and implementation of active members for precision space structures

    NASA Technical Reports Server (NTRS)

    Webster, M. S.; Fanson, J. L.; Lurie, B. J.; O'Brien, J. F.

    1992-01-01

    This paper describes the development and implementation of an active member in a precision truss structure. The active member utilizes a piezoelectric actuator motor imbedded in a steel case with built-in displacement sensor. This active member is used in structural quieting. Collocated active damping control loops are designed in order to impedance match piezoelectric active members to the structure. Results from application of these controllers and actuators to the JPL Phase B testbed are given.

  10. Perceived deprivation in active duty military nurse anesthetists.

    PubMed

    Pearson, Julie A; Fallacaro, Michael D; Pellegrini, Joseph E

    2009-02-01

    There is a shortage of military Certified Registered Nurse Anesthetists (CRNAs). Relative deprivation is a perception of unfairness due to discrepancies between what one has and what one could or should have that is dependent on feelings (subjective data) and facts (objective data). Feelings of relative deprivation could contribute to the military CRNA shortage. The purposes of this study were to measure relative deprivation in active-duty military CRNAs and explore variables that correlate with relative deprivation. The descriptive, correlational study was conducted using a self-administered survey sent to 435 active-duty Army, Navy, and Air Force CRNAs. Surveys were distributed to subjects by mail and could be answered by mail or by secured website. Data were analyzed using descriptive and inferential statistics. Analysis of the data revealed a calculated response rate of 57.7%. There was no significant correlation (P < .05) between years as a CRNA, military pay, promotion opportunity, or scope of practice/autonomy and relative deprivation. Correlations of the psychological factors "wanting" and "deserving" with relative deprivation were significant (P < .001). Further research is indicated to identify definitive factors that can be modified to improve feelings of deprivation as they relate to retention and recruitment of military CRNAs.

  11. Past Childhood Abuse and Present Alcohol Use as Risk Factors for Suicidal Ideation and Suicide Attempt in United States Military Active Duty Personnel, 2008

    DTIC Science & Technology

    2012-04-01

    Abuse and Alcoholism, Research Findings on Underage Drinking and the Minimum Legal Drinking Age, 28 Aug 2008, URL: http://www.niaaa.nih.gov/AboutNIAAA...a notable rate of current heavy drinking among members. Prior studies in the general population demonstrated associations between childhood abuse...of active duty military revealed a high prevalence of members with past childhood abuse and a notable rate of current heavy drinking among members

  12. 77 FR 40892 - Agency Information Collection Activities: Crew Member's Declaration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Crew Member's... other Federal agencies to comment on an information collection requirement concerning the Crew Member's... CBP is soliciting comments concerning the following information collection: Title: Crew...

  13. Active-duty military service members’ visual representations of PTSD and TBI in masks

    PubMed Central

    Walker, Melissa S.; Kaimal, Girija; Gonzaga, Adele M. L.; Myers-Coffman, Katherine A.; DeGraba, Thomas J.

    2017-01-01

    ABSTRACT Active-duty military service members have a significant risk of sustaining physical and psychological trauma resulting in traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Within an interdisciplinary treatment approach at the National Intrepid Center of Excellence, service members participated in mask making during art therapy sessions. This study presents an analysis of the mask-making experiences of service members (n = 370) with persistent symptoms from combat- and mission-related TBI, PTSD, and other concurrent mood issues. Data sources included mask images and therapist notes collected over a five-year period. The data were coded and analyzed using grounded theory methods. Findings indicated that mask making offered visual representations of the self related to individual personhood, relationships, community, and society. Imagery themes referenced the injury, relational supports/losses, identity transitions/questions, cultural metaphors, existential reflections, and conflicted sense of self. These visual insights provided an increased understanding of the experiences of service members, facilitating their recovery.

  14. Decision-Making Styles of Active-Duty Police Officers: A Multiple-Case Occupational Study

    ERIC Educational Resources Information Center

    Calhoun, Patrick Wayne

    2013-01-01

    Little is known about the decision-making styles of active-duty police officers or what the consequences of not understanding those decision-making styles may be. The purpose of the study was to describe the demographics and decision-making profiles of active-duty police officers, as well as any relationships that may exist among these variables,…

  15. Barriers and Facilitators of Breastfeeding for Primiparous Active Duty Military Mothers: A Qualitative Study

    DTIC Science & Technology

    1999-05-11

    allowing more rapid involution of the uterus and decreased postpartum bleeding. Amenorrhea caused by breastfeeding results in less menstrual blood loss in...BARRIERS AND FACILITATORS OF BREASTFEEDING FOR PRIMIPAROUS ACTIVE DUTY MILITARY MOTHERS: A QUALITATIVE STUDY Kristine Markley Bristow APPROVED... BREASTFEEDING FOR PRIMIPAROUS ACTIVE DUTY MILITARY MOTHERS: A QUALITATIVE STUDY” beyond brief excerpts is with the permission of the copyright owner, and

  16. Barriers and Facilitators of Breasteeding for Primiparous Active Duty Military Mothers: A Qualitative Study

    DTIC Science & Technology

    1999-05-01

    Breastfeeding increases oxytocin levels, allowing more rapid involution of the uterus and decreased postpartum bleeding. Amenorrhea caused by breastfeeding ...BARRIERS AND FACILITATORS OF BREASTFEEDING FOR PRIMIPAROUS ACTIVE DUTY MILITARY MOTHERS: A QUALITATIVE STUDY Kristine Markley Bristow APPROVED...FACILITATORS OF BREASTFEEDING FOR PRIMIPAROUS ACTIVE DUTY MILITARY MOTHERS: A QUALITATIVE STUDY 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM

  17. Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers.

    PubMed

    Dretsch, Michael N; Silverberg, Noah; Gardner, Andrew J; Panenka, William J; Emmerich, Tanja; Crynen, Gogce; Ait-Ghezala, Ghania; Chaytow, Helena; Mathura, Venkat; Crawford, Fiona C; Iverson, Grant L

    2017-02-15

    Risk factors for concussion in active-duty military service members are poorly understood. The present study examined the association between self-reported concussion history and genetics (apolipoprotein E [APOE], brain-derived neurotrophic factor [BDNF], and D2 dopamine receptor genes [DRD2]), trait personality measures (impulsive-sensation seeking and trait aggression-hostility), and current alcohol use. The sample included 458 soldiers who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring Freedom. For those with the BDNF Met/Met genotype, 57.9% (11/19) had a history of one or more prior concussions, compared with 35.6% (154/432) of those with other BDNF genotypes (p = 0.049, odds ratio [OR] = 2.48). APOE and DRD2 genotypes were not associated with risk for past concussions. Those with the BDNF Met/Met genotype also reported greater aggression and hostility personality characteristics. When combined in a predictive model, prior military deployments, being male, and having the BDNF Met/Met genotype were independently associated with increased lifetime history of concussions in active-duty soldiers. Replication in larger independent samples is necessary to have more confidence in both the positive and negative genetic associations reported in this study.

  18. Active member bridge feedback control for damping augmentation

    NASA Technical Reports Server (NTRS)

    Chen, Gun-Shing; Lurie, Boris J.

    1992-01-01

    An active damping augmentation approach using active members in a structural system is described. The problem of maximizing the vibration damping in a lightly damped structural system is considered using the analogy of impedance matching between the load and source impedances in an electrical network. The proposed active damping augmentation approach therefore consists of finding the desired active member impedances that maximize the vibration damping, and designing a feedback control in order to achieve desired active member impedances. This study uses a bridge feedback concept that feeds back a combination of signals from sensors of the axial force and relative velocity across the active member to realize the desired active member impedance. The proposed active damping augmentation approach and bridge feedback concept were demonstrated on a three-longeron softly suspended truss structure.

  19. 38 CFR 17.31 - Duty periods defined.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Definitions and Active Duty § 17.31 Duty periods defined. Full-time duty as a member of the Women's Army Auxiliary Corps, Women's Reserve of the Navy and Marine Corps and Women's Reserve of the Coast Guard... Patient Rights...

  20. Incidence of Norovirus-Associated Medical Encounters among Active Duty United States Military Personnel and Their Dependents

    PubMed Central

    Rha, Brian; Lopman, Benjamin A.; Alcala, Ashley N.; Riddle, Mark S.; Porter, Chad K.

    2016-01-01

    Background Norovirus is a leading cause of gastroenteritis episodes and outbreaks in US military deployments, but estimates of endemic disease burden among military personnel in garrison are lacking. Methods Diagnostic codes from gastroenteritis-associated medical encounters of active duty military personnel and their beneficiaries from July 1998–June 2011 were obtained from the Armed Forces Health Surveillance Center. Using time-series regression models, cause-unspecified encounters were modeled as a function of encounters for specific enteropathogens. Model residuals (representing unexplained encounters) were used to estimate norovirus-attributable medical encounters. Incidence rates were calculated using population data for both active duty and beneficiary populations. Results The estimated annual mean rate of norovirus-associated medically-attended visits among active duty personnel and their beneficiaries was 292 (95% CI: 258 to 326) and 93 (95% CI: 80 to 105) encounters per 10,000 persons, respectively. Rates were highest among beneficiaries <5 years of age with a median annual rate of 435 (range: 318 to 646) encounters per 10,000 children. Norovirus was estimated to cause 31% and 27% of all-cause gastroenteritis encounters in the active duty and beneficiary populations, respectively, with over 60% occurring between November and April. There was no evidence of any lag effect where norovirus disease occurred in one population before the other, or in one beneficiary age group before the others. Conclusions Norovirus is a major cause of medically-attended gastroenteritis among non-deployed US military active duty members as well as in their beneficiaries. PMID:27115602

  1. Advanced Marketing 8130. Instructional Areas. Duties and Tasks. Learning Activities. Referenced Resources.

    ERIC Educational Resources Information Center

    Virginia State Dept. of Education, Richmond.

    This resource handbook, which is designed for use by instructors of courses in advanced marketing, consists of a duty/task list with referenced resources, a duty/task list with learning activities, and a list of resources. Included in each list are materials dealing with the following topics: communication in marketing, economics in marketing,…

  2. Idiopathic renal infarction in a previously healthy active duty soldier.

    PubMed

    Eickhoff, Christa; Mei, Jian M; Martinez, Jorge; Little, Dustin

    2014-02-01

    Renal infarction (RI) is rare, and usually occurs in patients with associated comorbidities. The majority of reported cases have presented with laboratory abnormalities, most notably leukocytosis and elevated lactate dehydrogenase (LDH). A 50-year-old active duty white male nonsmoker without medical history presented with flank pain. Urinalysis, complete blood count, LDH, and serum creatinine were normal. Contrast-enhanced computed tomography of the abdomen and pelvis showed a right-sided RI. The patient was admitted to the hospital and anticoagulated. Laboratory values remained normal, and a comprehensive workup failed to reveal an etiology for his RI. RI is rare, and affected patients often present with symptoms similar to more common conditions such as lumbago or nephrolithiasis. Elevated LDH may be a clue to the diagnosis, but unlike 92% of the reviewed cases, our patient presented with a normal value. This case suggests that clinicians should consider RI in patients with persistent symptoms for whom more common causes of flank pain have been excluded; including in nonsmoking patients without apparent risk factors for infarction who present with a normal LDH and no leukocytosis.

  3. NASA Elementary Aerospace Activities Free to Members

    ERIC Educational Resources Information Center

    Journal of Aerospace Education, 1978

    1978-01-01

    Describes the contents of Elementary School Aerospace Activities: A Resource for Teachers. Activities examine a variety of topics in aerospace education and are intended to be used with children ages 5-11. The book is available from the Government Printing Office (GPO) for $3.00. (CP)

  4. Development of magnetostrictive active members for control of space structures

    NASA Technical Reports Server (NTRS)

    Johnson, Bruce G.; Avakian, Kevin M.; Fenn, Ralph C.; Gaffney, Monique S.; Gerver, Michael J.; Hawkey, Timothy J.; Boudreau, Donald J.

    1992-01-01

    The goal of this Phase 2 Small Business Innovative Research (SBIR) project was to determine the technical feasibility of developing magnetostrictive active members for use as truss elements in space structures. Active members control elastic vibrations of truss-based space structures and integrate the functions of truss structure element, actively controlled actuator, and sensor. The active members must control structural motion to the sub-micron level and, for many proposed space applications, work at cryogenic temperatures. Under this program both room temperature and cryogenic temperature magnetostrictive active members were designed, fabricated, and tested. The results of these performance tests indicated that room temperature magnetostrictive actuators feature higher strain, stiffness, and force capability with lower amplifier requirements than similarly sized piezoelectric or electrostrictive active members, at the cost of higher mass. Two different cryogenic temperature magnetostrictive materials were tested at liquid nitrogen temperatures, both with larger strain capability than the room temperature magnetostrictive materials. The cryogenic active member development included the design and fabrication of a cryostat that allows operation of the cryogenic active member in a space structure testbed.

  5. Effects of combat deployment on risky and self-destructive behavior among active duty military personnel.

    PubMed

    Thomsen, Cynthia J; Stander, Valerie A; McWhorter, Stephanie K; Rabenhorst, Mandy M; Milner, Joel S

    2011-10-01

    Although research has documented negative effects of combat deployment on mental health, few studies have examined whether deployment increases risky or self-destructive behavior. The present study addressed this issue. In addition, we examined whether deployment effects on risky behavior varied depending on history of pre-deployment risky behavior, and assessed whether psychiatric conditions mediated effects of deployment on risky behavior. In an anonymous survey, active duty members of the U.S. Marine Corps and U.S. Navy (N = 2116) described their deployment experiences and their participation in risky recreational activities, unprotected sex, illegal drug use, self-injurious behavior, and suicide attempts during three time frames (civilian, military pre-deployment, and military post-deployment). Respondents also reported whether they had problems with depression, anxiety, or PTSD during the same three time frames. Results revealed that risky behavior was much more common in civilian than in military life, with personnel who had not deployed, compared to those who had deployed, reporting more risky behavior and more psychiatric problems as civilians. For the current time period, in contrast, personnel who had deployed (versus never deployed) were significantly more likely to report both risky behavior and psychiatric problems. Importantly, deployment was associated with increases in risky behavior only for personnel with a pre-deployment history of engaging in risky behavior. Although psychiatric conditions were associated with higher levels of risky behavior, psychiatric problems did not mediate associations between deployment and risky behavior. Implications for understanding effects of combat deployment on active duty personnel and directions for future research are discussed.

  6. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  7. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  8. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  9. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  10. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  11. Department of Defense Survey of Health Related Behaviors Among Active Duty Military Personnel

    DTIC Science & Technology

    2009-09-01

    Assessment Program (DLAP), which incorporates the active duty health behaviors study and expands the scope to include the National Guard and Reserves, as...well as other special studies . Findings from the program provide information on the fitness of the force, including estimates of alcohol, drug, and...first to include Coast Guard personnel. The study has three broad aims for active duty military personnel: continue to assess the nature, extent, and

  12. Heavy-duty truck population, activity and usage patterns. Final report

    SciTech Connect

    Fischer, M.

    1998-07-01

    The objective of the study was to update the heavy-duty truck (HDT) population, activity (e.g., vehicle miles traveled (VMT), numbers of starts and trips, trip duration, etc.), and usage patterns type of service/business (e.g., delivery, construction, etc.), area of operation (i.e., local, short-haul, long-haul) for HDT`s registered and/or operated in California. The population and activity estimates were done on a weight-class-specific basis light-heavy-duty, medium-heavy-duty and heavy-heavy-duty. Population, activity and usage estimates were based primarily on Department of Motor Vehicles (DMV) registration data and Truck Inventory and Usage Survey (TIUS) data. In addition to the analysis of existing data (i.e., DMV and TIUS), 42 HDTs were fitted with on-board data loggers that recorded numbers of trips and starts, daily VMT and travel by time-of-day.

  13. Injuries from Participation in Sports, Exercise, and Recreational Activities Among Active Duty Service Members - Analysis of the April 2008 Status of Forces Survey of Active Duty Members

    DTIC Science & Technology

    2011-09-13

    Most people can complete the survey in 30 minutes or less. There is no penalty or loss of benefits to which you are entitled if you choose not to...POTENTIAL BENEFITS : DMDC uses well-established, scientific procedures to select a sample that represents the Defense community. This sampling procedure...these clusters of people. This is your chance to be heard on issues that directly affect you. While there is no direct benefit for your individual

  14. 1999 Survey of Active Duty Personnel: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2000-12-01

    with the survey’s lithocode to ensure quality . Any mismatched pairs initiated further investigation of the matching process. This procedure ensured...Introduction to variance estimation. New York: Springer-Verlag. Woodruff, R. (1952). Confidence intervals for medians and other positional measures ...characteristics of your current residence and community at your permanent duty station? a. Cost of residence b. Quality and condition of residence c. Amount of

  15. Tibial stress fractures in an active duty population: long-term outcomes.

    PubMed

    Kilcoyne, Kelly G; Dickens, Jonathan F; Rue, John-Paul

    2013-01-01

    Tibial stress fractures are a common overuse injury among military recruits. The purpose of this study was to determine what, if any, long-term effects that tibial stress fractures have on military personnel with respect to physical activity level, completion of military training, recurrence of symptoms, and active duty service. Twenty-six military recruits included in a previous tibial stress fracture study were contacted 10 years after initial injury and asked a series of questions related to any long-term consequences of their tibial stress fracture. Of the 13 patients available for contact, no patients reported any necessary limited duty while on active duty, and no patient reported being separated or discharged from the military as a result of stress fracture. Tibial stress fractures in military recruits are most often an isolated injury and do not affect ability to complete military training or reflect a long-term need for decreased physical activity.

  16. Test-retest reliability of four computerized neurocognitive assessment tools in an active duty military population.

    PubMed

    Cole, Wesley R; Arrieux, Jacques P; Schwab, Karen; Ivins, Brian J; Qashu, Felicia M; Lewis, Steven C

    2013-11-01

    Computerized neurocognitive assessment tools (NCATs) are increasingly used for baseline and post-concussion assessments. To date, NCATs have not demonstrated strong test-retest reliabilities. Most studies have used non-military populations and different methodologies, complicating the determination of the utility of NCATs in military populations. The test-retest reliability of four NCATs (Automated Neuropsychological Assessment Metrics 4 [ANAM4], CNS-Vital Signs, CogState, and Immediate Post-Concussion Assessment and Cognitive Test [ImPACT]) was investigated in a healthy active duty military sample. Four hundred and nineteen Service Members were randomly assigned to take one NCAT and 215 returned after approximately 30 days for retest. Participants deemed to have inadequate effort during one or both testing sessions, according to the NCATs scoring algorithms, were removed from analyses. Each NCAT had at least one reliability score (intraclass correlation) in the "adequate" range (.70-.79), only ImPACT had one score considered "high" (.80-.89), and no scores met "very high" criteria (.90-.99). However, overall test-retest reliabilities in four NCATs in a military sample are consistent with reliabilities reported in the literature and are lower than desired for clinical decision-making.

  17. 38 CFR 21.46 - Veteran ordered to active duty; extension of basic period of eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Periods of Eligibility § 21.46 Veteran ordered to active... active duty under 10 U.S.C. 688, 12301(a), 12301(d), 12301(g), 12302, or 12304, the veteran's basic... months. (Authority: 38 U.S.C. 3103(e); sec. 308(h), Pub. L. 107-330, 116 Stat. 2829)...

  18. Dental utilization of active duty/previous active duty US military: a cross-sectional analysis of the 2010 Behavior and Risk Surveillance Survey

    PubMed Central

    Sambamoorthi, Usha; Jurevic, Richard J

    2015-01-01

    Introduction The purpose of this study is to understand dental utilization of 1) individuals serving/having served in active duty in the U.S. military as compared with the general public and 2) individuals who are currently serving as compared with individuals who are no longer active duty, but have been in active duty within the previous year. Methods The Behavior and Risk Surveillance Survey, 2010, was used in cross-sectional analyses to determine the comparisons. Chi square and multivariable logistic regression analyses were applied. Results 70.7% of participants who had served/currently serving had a dental visit within the previous 12 months; 69.9% of the general public reported a dental visit (p = 0.0265). 69.8% of participants who had served/currently serving had a dental hygiene visit within the previous 12 months and 68.1% of the general public reported a dental hygiene visit (p <0.0001). The adjusted odds ratio (AOR) for participants who had served/currently serving vs. the general public was 1.10 (95% Confidence Interval [CI] 1.05, 1.16; p<0.0001) for dental visits and 1.11 (95%CI 1.05, 1.17; p<0.0001) for dental hygiene visits. Conclusion Participants who are serving or have served were more likely to have any dental visit and dental hygiene visit than the general public; but the results were not substantively important. PMID:26086028

  19. 77 FR 60132 - Agency Information Collection Activities; Crew Member's Declaration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities; Crew Member's Declaration AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: 30-Day notice and request for comments; Extension of an existing information collection. SUMMARY: U.S. Customs...

  20. Sexual Harassment in the Active-Duty Navy: Findings from the 1991 Navy-Wide Survey

    DTIC Science & Technology

    1993-12-01

    NPRDC-TR-94-2) harassed. This direct query method has the advantage of recognizing the complexities involved in deciding whether sexually - oriented ...NPRDC-TR-94-2 December 13 Sexual Harassment in the Active-Duty Navy: Findings from the 1991 Navy-Wide Survey ɘ DTIC Authors ELECTE Amy L Culbertson...1991-1992 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Sexual Harassment in the Active-Duty Navy: N0002293WREE500 Findings from the 1991 Navy-Wide Survey 6

  1. Active Members Excite And Measure Vibrations In Trusses

    NASA Technical Reports Server (NTRS)

    Kuo, Chin-Po; Chen, Gun-Shing; Wada, Ben K.

    1993-01-01

    Report describes experimental study of use of active structural members to excite and measure vibrations as small as microns in truss structure. Part of continuing effort to develop active vibration-suppressing control system adapting itself to changing and/or partly unknown dynamical characteristics of truss structure in outer space. Some aspects of control concept and potential terrestrial applications described in "Two Techniques For Suppressing Vibrations In Structures" (NPO-17889).

  2. 8 CFR 329.5 - Natives of the Philippines with active duty service during World War II.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Natives of the Philippines with active duty service during World War II. 329.5 Section 329.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... of the Philippines with active duty service during World War II. (a) A person desiring to...

  3. 8 CFR 329.5 - Natives of the Philippines with active duty service during World War II.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Natives of the Philippines with active duty service during World War II. 329.5 Section 329.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... Natives of the Philippines with active duty service during World War II. (a) A person desiring...

  4. 75 FR 49913 - Active Duty Service Determinations For Civilian or Contractual Groups

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... Department of the Air Force Active Duty Service Determinations For Civilian or Contractual Groups SUMMARY: On July 30, 2010, the Secretary of the Air Force, acting as Executive Agent of the Secretary of Defense...'' for purposes of all laws administered by the Department of Veterans Affairs (VA). FOR...

  5. Active Duty Female Military’s Experience of Fear, Embarrassment, and Distress During Pelvic Examinations

    DTIC Science & Technology

    2011-03-01

    1 1. Sexual Violence While on Active Duty...............................................2 2. Sexual Violence Prior to Military...Service .........................................3 3. History of Sexual Violence Associated With Physical and Mental Health Issues...experience of one or more of the following: (1) verbal and/or physical sexual harassment; (2) attempted sexual assault, or the attempt to force sexual

  6. 78 FR 7802 - Agency Information Collection Activities: Application for Allowance in Duties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Application for Allowance in Duties AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: 30.... SUMMARY: U.S. Customs and Border Protection (CBP) of the Department of Homeland Security will...

  7. Standard of care of erectile dysfunction in U.S. Air Force aircrew and active duty not on flying status.

    PubMed

    Nast, Justin B

    2014-11-01

    In 2011, over 3,000 active duty U.S. Air Force (USAF) members were prescribed a phosphodiesterase inhibitor (PDEI). PDEIs are first-line therapy for treating erectile dysfunction and can have significant side effects that could impact aircrew performance. In total, 200 eligible subject records were randomly sampled from the active duty USAF population of those males filling a prescription for a PDEI in June 2011; 100 of those records were from aviators. The electronic records were reviewed and scored to determine if USAF aeromedical standards for prescribing PDEIs were followed, with a minimum score of 0 for no standards met and a maximum of 3 for all standards met. The average score for both groups was 1, with no significant difference between the group scores. A proper aeromedical disposition was documented in 67% of the aviator records. Although there was no significant difference in standard of care for aviators and nonaviators, the overall documented standard of care was poor. Lack of documentation was the primary reason for the low scores and the low percentage of properly rendered aeromedical dispositions. Proper medical record documentation is important for evaluating quality of care and ensuring compliance with regulations in an Air Force aviator population.

  8. Structural damage detection using active members and neural networks

    NASA Astrophysics Data System (ADS)

    Manning, R. A.

    1994-06-01

    The detection of damage in structures is a topic which has considerable interest in many fields. In the past many methods for detecting damage in structures has relied on finite element model refinement methods. This note presents a structural damage methodology in which only active member transfer function data are used in conjunction with an artificial neural network to detect damage in structures. Specifically, the method relies on training a neural network using active member transfer function pole/zero information to classify damaged structure measurements and to predict the degree of damage in the structure. The method differs from many of the past damage detection algorithms in that no attempt is made to update a finite element model or to match measured data with new finite element analyses of the structure in a damaged state.

  9. Caffeine Use among Active Duty Navy and Marine Corps Personnel

    PubMed Central

    Knapik, Joseph J.; Trone, Daniel W.; McGraw, Susan; Steelman, Ryan A.; Austin, Krista G.; Lieberman, Harris R.

    2016-01-01

    Data from the National Health and Nutrition Examination Survey (NHANES) indicate 89% of Americans regularly consume caffeine, but these data do not include military personnel. This cross-sectional study examined caffeine use in Navy and Marine Corps personnel, including prevalence, amount of daily consumption, and factors associated with use. A random sample of Navy and Marine Corps personnel was contacted and asked to complete a detailed questionnaire describing their use of caffeine-containing substances, in addition to their demographic, military, and lifestyle characteristics. A total of 1708 service members (SMs) completed the questionnaire. Overall, 87% reported using caffeinated beverages ≥1 time/week, with caffeine users consuming a mean ± standard error of 226 ± 5 mg/day (242 ± 7 mg/day for men, 183 ± 8 mg/day for women). The most commonly consumed caffeinated beverages (% users) were coffee (65%), colas (54%), teas (40%), and energy drinks (28%). Multivariable logistic regression modeling indicated that characteristics independently associated with caffeine use (≥1 time/week) included older age, white race/ethnicity, higher alcohol consumption, and participating in less resistance training. Prevalence of caffeine use in these SMs was similar to that reported in civilian investigations, but daily consumption (mg/day) was higher. PMID:27735834

  10. Caffeine Use among Active Duty Navy and Marine Corps Personnel.

    PubMed

    Knapik, Joseph J; Trone, Daniel W; McGraw, Susan; Steelman, Ryan A; Austin, Krista G; Lieberman, Harris R

    2016-10-09

    Data from the National Health and Nutrition Examination Survey (NHANES) indicate 89% of Americans regularly consume caffeine, but these data do not include military personnel. This cross-sectional study examined caffeine use in Navy and Marine Corps personnel, including prevalence, amount of daily consumption, and factors associated with use. A random sample of Navy and Marine Corps personnel was contacted and asked to complete a detailed questionnaire describing their use of caffeine-containing substances, in addition to their demographic, military, and lifestyle characteristics. A total of 1708 service members (SMs) completed the questionnaire. Overall, 87% reported using caffeinated beverages ≥1 time/week, with caffeine users consuming a mean ± standard error of 226 ± 5 mg/day (242 ± 7 mg/day for men, 183 ± 8 mg/day for women). The most commonly consumed caffeinated beverages (% users) were coffee (65%), colas (54%), teas (40%), and energy drinks (28%). Multivariable logistic regression modeling indicated that characteristics independently associated with caffeine use (≥1 time/week) included older age, white race/ethnicity, higher alcohol consumption, and participating in less resistance training. Prevalence of caffeine use in these SMs was similar to that reported in civilian investigations, but daily consumption (mg/day) was higher.

  11. Pathways of Risk and Resilience: Impact of a Family Resilience Program on Active-Duty Military Parents.

    PubMed

    Saltzman, William R; Lester, Patricia; Milburn, Norweeta; Woodward, Kirsten; Stein, Judith

    2016-12-01

    Over the past decade, studies into the impact of wartime deployment and related adversities on service members and their families have offered empirical support for systemic models of family functioning and a more nuanced understanding of the mechanisms by which stress and trauma reverberate across family and partner relationships. They have also advanced our understanding of the ways in which families may contribute to the resilience of children and parents contending with the stressors of serial deployments and parental physical and psychological injuries. This study is the latest in a series designed to further clarify the systemic functioning of military families and to explicate the role of resilient family processes in reducing symptoms of distress and poor adaptation among family members. Drawing upon the implementation of the Families Overcoming Under Stress (FOCUS) Family Resilience Program at 14 active-duty military installations across the United States, structural equation modeling was conducted with data from 434 marine and navy active-duty families who participated in the FOCUS program. The goal was to better understand the ways in which parental distress reverberates across military family systems and, through longitudinal path analytic modeling, determine the pathways of program impact on parental distress. The findings indicated significant cross-influence of distress between the military and civilian parents within families, families with more distressed military parents were more likely to sustain participation in the program, and reductions in distress among both military and civilian parents were significantly mediated by improvements in resilient family processes. These results are consistent with family systemic and resilient models that support preventive interventions designed to enhance family resilient processes as an important part of comprehensive services for distressed military families.

  12. Gender differences in the expression of PTSD symptoms among active duty military personnel.

    PubMed

    Hourani, Laurel; Williams, Jason; Bray, Robert; Kandel, Denise

    2015-01-01

    This study examined gender differences in posttraumatic stress disorder (PTSD) symptoms and symptom factors in the total U.S. active duty force. Data were drawn from the 2008 Department of Defense Survey of Health Related Behaviors among Active Duty Military Personnel including 17,939 men and 6751 women from all services. The results indicated that women expressed more distress than men across almost all the symptoms on the PTSD Checklist except for hypervigilance. Women also scored significantly higher on all four factors examined: Re-experiencing, Avoidance, Emotionally Numb, Hyperarousal. More women than men were distressed by combat experiences that involved some type of violence, such as being wounded, witnessing or engaging in acts of cruelty, engaging in hand-to-hand combat, and, to a lesser extent, handling dead bodies. Men who had been sexually abused had a greater number of symptoms and were consistently more distressed than women on individual symptoms and symptom factors.

  13. Spice: A New Legal Herbal Mixture Abused by Young Active Duty Military Personnel

    DTIC Science & Technology

    2012-01-01

    Spice: A New “Legal” Herbal Mixture Abused by Young Active Duty Military Personnel Vikhyat S. Bebarta, MD Sasha Ramirez, DO Shawn M. Varney, MD...ABSTRACT. Spice is an herbal mixture smoked for euphoria and mixed with synthetic cannabinoids that are undetected on urine drug screens. Spice use has...drug paraphernalia. Spice is a new herbal mixture that is increasingly used in the military. Expected effects are similar to cannabis, but may include

  14. Experience of Postpartum Active Duty Women in Training for the Fitness Assessment

    DTIC Science & Technology

    2014-09-10

    complications N=6 Breastfeeding Issues N=8 Sadness/lowered self- esteem N=4 Fear of failing fitness assessment N=11 *Known data from 3 pilot...to breastfeeding . Emotional changes included feelings of sadness, feeling emotionally drained, feeling overwhelmed, and lowered self-esteem... breastfeeding would be beneficial. These results strongly suggest that close follow-up of active duty women after delivery is essential in order to

  15. 2006 Workplace and Gender Relations Survey of Active Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2010-12-01

    Communications ..................................................................................................................B-1 C. Annotated...by Service ........................................................................................19 E-mail Communication Timeline...opinions of the entire Department of Defense (DoD) community on a wide range of personnel issues. Human Relations Surveys are in-depth studies of topics

  16. April 2004 Status of Forces Survey of Active-Duty Members: Tabulations of Responses

    DTIC Science & Technology

    2004-08-01

    Evaluation Branch, and Felicia Dehaney, Michael Ford, Margaret Holland, Zachary Horn, and Julisara Mathews, Consortium Research Fellows, completed quality ...48 d. The quality of your coworkers ...............................................................50 e. The quality of your supervisor...222 a. Availability of child care.......................................................................222 b. Quality of child

  17. November 2003 Status of Forces Survey of Active-Duty Members Tabulations of Responses

    DTIC Science & Technology

    2004-03-01

    Lindsay Rock, Consortium Research Fellows, completed quality control for this tabulation volume. DMDC iii Table of Contents Page...48 d. The quality of your coworkers...50 e. The quality of your supervisor ................................................................... 52 21. Overall, how

  18. August 2005 Status of Forces Survey of Active-Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2005-09-01

    benefits, education and training, spouse education and employment opportunities, children’s education, and general quality of life. 15. Balancing Work...numbers printed on the letter with the brochure or survey number for quality control. Any mismatched pairs initiated further investigation of the...c. Your opportunities for promotion d. The quality of your coworkers

  19. 2006 Workplace and Gender Relations Survey of Active Duty Members: Report on Scales and Measures

    DTIC Science & Technology

    2008-03-01

    2006 WGRA) was conducted on behalf of the Office of the Under Secretary of Defense for Personnel and Readiness (OUSD[P& R ]). DMDC’s survey program... Kidwell , 2006). Following this single item is a multi-item measure that assesses the one experience of unwanted sexual contact that had the...The majority of Item 35 (35A-M, O-P, R , and S) is based on the Sexual Experiences Questionnaire17 (SEQ; Fitzgerald, et al., 1988; Fitzgerald

  20. 32 CFR 161.10 - Benefits for active duty members of the uniformed services.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and DoD Instruction 1330.17, “Armed Services Commissary Operations” (available at http://www.dtic.mil...” (available at http://www.dtic.mil/whs/directives/corres/pdf/133021p.pdf); and DoD Instruction...

  1. April 2004 Status of Forces Survey of Active-Duty Members: Administration, Datasets and Codebook

    DTIC Science & Technology

    2004-08-01

    Center (Deever & Mason, 2002). A formal mathematical procedure ( Chromy , 1987) based on Karush-Kuhn- Tucker theory is used in the sample-planning tool to...Retrieved May 31, 2002, from http://www.census.gov/prod/2002pubs/tp63rv.pdf Chromy , J. R. (1987). Design optimization with multiple objectives...FINSPTB* 65b. [60b] Inc source-alimony or child sppt 324 FINSPTBR Rec FINSPTB-Inc source-alimony chld supt 140 FINSPTBU* [60b] Inc source-al

  2. March 2005 Status of Forces Survey of Active-Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2005-10-01

    deply 207 FCOPEER2* Briefing: family cope know length deploy 692 FCOPEEU* [55e] Cope deploy F: Know expected-Uned 469 FINALWGT Final Weight w...grade group 999 PAYGRDE5* Pay grade group 1000 PCS 26. [26---] Have U ever PCSed 11 PCSLAST* 27. [27---] Months since last PCS 351 —353 PCSLASTR...Reunion planning info 205 FCOPEDR Recode FCOPED- Contact w/mbr in unit 206 FCOPEER Recode FCOPEE- Know exp leng of deply 207 FMGMTAR Recode

  3. August 2006 Status of Forces Survey of Active Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2006-12-01

    67] Factors of decision to stay-second 348—349 RENFC2R1 Rec RENFC2- 2nd most import factor 1-10 207 RENFC2R2 Rec RENFC2-2nd most import factor...2nd most import factor 41-42 211 RENFC2SPSK* Other fctrs of decision to stay-2nd 353 RENFC3* 68. [68] Factors of decision to stay-third 350— 351 ...205 RENFC1R5 Rec RENFC1-Most import factor stay 41-42 206 RENFC2R1 Rec RENFC2- 2nd most import factor 1-10 207 RENFC2R2 Rec RENFC2-2nd most

  4. August 2004 Status of Forces Survey of Active-Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2005-01-01

    AF104* 104. [104--] Retire alt enlisted 200-pre 350 AF104SK* [3--] Paygrade -Skip 351 AF104U* [104--] Retire alt enlisted 200-pre-Uned 508 AF105...crrnt NGR full-time yes/no 207 PRSEMP02SK* [4--] Marital status -Skip 208 PRSEMP02U* [7--] Spouse crrnt NGR full-time ye-Uned 433 PRSEMP03* 8...Marital status -Skip 206 PRSEMP02 7. [7--] Spouse crrnt NGR full-time yes/no 207 PRSEMP02SK [4--] Marital status -Skip 208 PRSEMP03 8. [8--] Spouse

  5. 2012 Workplace and Gender Relations Survey of Active Duty Members (Survey Note No. 2013-002)

    DTIC Science & Technology

    2013-01-18

    2006 Most recert HGI -ER than • 2002 Most recert LOJ\\ER than * Total Women 45 * Total Men 23 * 2010 2006 2010 2012 52~ 29 X 201 2 Serving...than 2006 100 80 "𔃺 Q) ’-’ c 60 Q) ·;:: Q) Q. X w c 40 Q) t:: Q) a.. lE 20 lE 0 2002 ~ * 2006 Most recert HGI -ER than • 2002...t:: Q) a.. 20 X :lK :lK ~ 0 2002 2006 2010 201 2 I Most recert HGI -ER than • 2002 2006 2010 2012 Most recert LOJ\\ER than * Total Women 8 9 8

  6. 2010 Workplace and Gender Relations Survey of Active Duty Members. Tabulations of Responses

    DTIC Science & Technology

    2011-04-01

    23,521 98% 1,334,994 ±3,044 99% ±1 Experienced SH 2,485 10% 79,933 ±5,203 6% ±1 Not Experienced SH 21,544 90% 1,274,430 ±5,339 94% ±1 FEMALES...1 Not Experienced USC 9,627 40% 185,713 ±1,535 14% ±1 Experienced SH 2,124 9% 41,374 ±1,898 3% ±1 Not Experienced SH 7,910 33% 152,948 ±2,190 11...Experienced SH 361 2% 38,559 ±4,846 3% ±1 Not Experienced SH 13,634 57% 1,121,483 ±5,041 83% ±1 Deployed Past 12 Months 5,573 23% 473,088

  7. 2005 Workplace and Equal Opportunity Survey of Active-Duty Members Administration, Datasets, and Codebook

    DTIC Science & Technology

    2007-06-01

    Offender: military subordinat-Uned 599 EA060F* 60f . [ 60f ] Offender: other mil persons 465 EA060FU* [ 60f ] Offender: other mil persons-Uned 600...60e. [60e] Offender: military subordinates 464 EA060F 60f . [ 60f ] Offender: other mil persons 465 EA060G 60g. [60g] Offender: civ emplyees 466 EA060H...60d] Offender: military coworkers-Uned 598 EA060EU [60e] Offender: military subordinat-Uned 599 EA060FU [ 60f ] Offender: other mil persons-Uned 600

  8. Development of a Multilevel Prevention Program for Improved Relationship Functioning in Active Duty Military Members

    DTIC Science & Technology

    2015-06-01

    Experience 8 9.30 (5) Information for Children; Managing Post-Traumatic Stress Disorder Symptoms Around Children; Single - Parent Support 6 7.00 (6...empirical support for parenting problems, but no similar program exists for couple problems. We conducted two studies with U.S. Air Force Security...integrates universal, selective, and indicated prevention/intervention. Such an approach has tremendous empirical support for parenting problems, but no

  9. 2005 Workplace and Equal Opportunity Survey of Active-Duty Members: Report on Scales and Measures

    DTIC Science & Technology

    2007-06-01

    past 12 months (see Table 11). Response options included 1 ( yes , and my race/ethnicity was a factor), 2 ( yes , but my race/ethnicity was NOT a factor...months. Response options included 1 (no) or 2 ( yes ). New to the 2005 WEOA, Item 49 asked survey participants whether they considered any of the...behaviors that they experienced in Items 45 to 48 to have been racial/ethnic harassment or discrimination. Response options included 1 ( yes , racial

  10. 2005 Workplace and Equal Opportunity Survey of Active-Duty Members. Overview Report

    DTIC Science & Technology

    2007-07-01

    illegal discrimination based on race, creed, color, sex , religion, or national origin; advocate the use of force or violence; or otherwise engage in...AIAN Asian NHPI Two/ More Yes , chances improved 6 4 5 13 NR 6 NR NR Yes , chances worse 20 18 22 21 NR 24 NR NR No, career not affected 75 78 73 65 NR...Two/ More E1-E4 9 7 3 NR NR NR NR NR E5-E9 4 3 6 5 NR 3 NR NR O1-O3 1 NR NR NR NR NR NR NR Yes , chances improved O4-O6 5 4 13 NR NR NR NR NR E1

  11. 2013 Workplace and Equal Opportunity Survey of Active Duty Members: Nonresponse Bias Report

    DTIC Science & Technology

    2014-10-01

    Analyze whether past Racial/Ethnic Harassment/Discrimination victims respond to later WEOA surveys at different rates. 6. Analyze mean Armed Forces...24 Section V: Analyze Whether Past Racial Discrimination Victims Respond to Later WEOA Surveys at Different Rates...25 Summary of Analyzing Whether Past Victims ’ Respond to Later WEOA Surveys at

  12. The Association Between Mental Health and Cigarette Smoking in Active Duty Military Members

    DTIC Science & Technology

    2011-02-01

    2.1.2 General Tobacco Use Costs ...................................................................... 1 2.1.3 Cigarette Smoking in Adolescents...Characteristics and Impact . Tobacco use is the single most preventable cause of death and disease in the United States. Approximately 21% of the U.S... pack of 20 cigarettes sold in the U.S. (low estimate) are $10.28. The average retail price per pack in the U.S. (including sales tax) is $4.20 (Ref

  13. December 2004 Status of Forces Survey of Active-Duty Members: Administration, Datasets. and Codebook

    DTIC Science & Technology

    2005-07-01

    nmlkj nmlkj nmlkj nmlkj SATISFACTION AND RETENTION INTENTION 21. Overall, how satisfied are you with the military way of life? nmlkjVery... satisfied nmlkj Satisfied nmlkjNeither satisfied nor dissatisfied nmlkjDissatisfied nmlkjVery dissatisfied SATISFACTION AND RETENTION INTENTION...nmlkj nmlkj SATISFACTION AND RETENTION INTENTION Edit NOT [SRSVC1] = ř" SATOVER 21. Overall, how satisfied are you with the military way of life

  14. December 2005 Status of Forces Survey of Active Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2006-06-01

    SATISFIED /DISSATISFIED*/ ELSE IF SATISF (J) IN (4,5) THEN SATISFR (J)=3; /* SATISFIED /VERY SATISFIED */ END; DROP J; /* coding for... SATISFACTION 21. Overall, how satisfied are you with the military way of life? A-6 ******** Page Break ********** ******** Page...E, 21; ARRAY SATISFY (*) SATMLA SATMLB SATMLC SATMLD SATMLE SATOVER; ARRAY SATISFYR (*) SATMLAR SATMLBR SATMLCR SATMLDR SATMLER SATOVERR;

  15. 2013 Workplace and Equal Opportunity Survey of Active Duty Members: Administration, Datasets, and Codebook

    DTIC Science & Technology

    2016-05-01

    Self-Report Ineligible 678 0.8 1 1 Very poorly prepared 1080 1.2 2 2 Poorly prepared 4539 5.1 3 3 Neither well nor poorly prepared 7504 8.5 4 4 Well...return 678 0.8 1 1 Very poorly prepared 1080 1.2 2 2 Poorly prepared 4539 5.1 3 3 Neither well nor poorly prepared 7504 8.5 4 4 Well prepared 5055 5.7

  16. 2015 Focus Groups on Sexual Assualt and Response Among Active Duty Members (2015 FGSAPR)

    DTIC Science & Technology

    2016-03-01

    ofsexualassault response and prevention. 15. SUBJECT TERMS " ~~ Perceptions about Unwanted Gender-Related Behaviors , Options for Reporting Sexual Assault...unwanted gender-related behaviors ; the focus groups provide deeper insights into the dynamics behind the survey results and help better understand...gender-related behaviors at their base/installation, but they do not portray a statistical report on prevalence rates or quantitative evaluation of

  17. MIF family members cooperatively inhibit p53 expression and activity.

    PubMed

    Brock, Stephanie E; Rendon, Beatriz E; Xin, Dan; Yaddanapudi, Kavitha; Mitchell, Robert A

    2014-01-01

    The tumor suppressor p53 is induced by genotoxic stress in both normal and transformed cells and serves to transcriptionally coordinate cell cycle checkpoint control and programmed cell death responses. Macrophage migration inhibitory factor (MIF) is an autocrine and paracrine acting cytokine/growth factor that promotes lung adenocarcinoma cell motility, anchorage-independence and neo-angiogenic potential. Several recent studies indicate that the only known homolog of MIF, D-dopachrome tautomerase (D-DT - also referred to as MIF-2), has functionally redundant activities with MIF and cooperatively promotes MIF-dependent pro-tumorigenic phenotypes. We now report that MIF and D-DT synergistically inhibit steady state p53 phosphorylation, stabilization and transcriptional activity in human lung adenocarcinoma cell lines. The combined loss of MIF and D-DT by siRNA leads to dramatically reduced cell cycle progression, anchorage independence, focus formation and increased programmed cell death when compared to individual loss of MIF or D-DT. Importantly, p53 mutant and p53 null lung adenocarcinoma cell lines were only nominally rescued from the cell growth effects of MIF/D-DT combined deficiency suggesting only a minor role for p53 in these transformed cell growth phenotypes. Finally, increased p53 activation was found to be independent of aberrantly activated AMP-activated protein kinase (AMPK) that occurs in response to MIF/D-DT-deficiency but is dependent on reactive oxygen species (ROS) that mediate aberrant AMPK activation in these cells. Combined, these findings suggest that both p53 wildtype and mutant human lung adenocarcinoma tumors rely on MIF family members for maximal cell growth and survival.

  18. Perspective on OECD activities from a non-member country.

    PubMed

    Alexandrova, Nevena; Atanassov, Atanas

    2006-01-01

    The OECD Blue Book, "Recombinant DNA: Safety Considerations" was published in 1986. The developed principles and concepts on the stepwise and case-by-case approach for risk assessment in the Blue Book have been used as a foundation for building national biosafety frameworks and international instruments for the regulation of the products of modern biotechnology. Twenty years after the Blue Book was published, OECD continues its activities on unique identifier systems, information-sharing, consensus documents for the biology of crops, trees and microorganisms with respect to harmonization of regulatory oversight and those of novel food and feed safety. These activities benefit, without any doubt, the international community at large, including OECD non-member countries. In order to strengthen its position in the international arena and to better respond to the needs of the changing world, OECD would be encouraged to participate in a more active manner in the technology transfer process and co-existence debate, together with continuing the organization's efforts on information-sharing and harmonization in the field of biotechnology and biosafety.

  19. Pilot study of the effects of mixed light touch manual therapies on active duty soldiers with chronic post-traumatic stress disorder and injury to the head.

    PubMed

    Davis, Lauren; Hanson, Brenda; Gilliam, Sara

    2016-01-01

    This pilot study was designed to examine the effects of mixed Light Touch Manual Therapies (LTMT) on headache, anxiety and other symptoms suffered by active duty United States service members experiencing chronic Post-Traumatic Stress Disorder (PTSD). Ten service members diagnosed with PTSD and having a self-reported injury to the head acquired at least two years prior, were provided with two hour-long sessions of mixed LTMT given a week apart. Data to assess the immediate and durable effects were gathered before and after the LTMT sessions. Results indicate that headache, anxiety, and pain interference were significantly reduced during the course of the pilot study. This suggests that mixed LTMT may be helpful in reducing some of the symptoms of PTSD and injury to the head. Further studies will be needed to determine if LTMT is an effective non-pharmacological treatment for headache, anxiety or other problems associated with PTSD or injury to the head.

  20. 78 FR 16654 - Certain Activated Carbon From the People's Republic of China: Continuation of Antidumping Duty Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... International Trade Administration Certain Activated Carbon From the People's Republic of China: Continuation of... activated carbon from the People's Republic of China (``PRC'') would likely lead to a continuation or... a sunset review of the antidumping duty order on certain activated carbon from the PRC, pursuant...

  1. Efficacy of a Tobacco Quitline in Active Duty Military and TRICARE Beneficiaries: A Randomized Trial.

    PubMed

    Klesges, Robert C; Ebbert, Jon O; Talcott, G Wayne; Thomas, Fridtjof; Richey, Phyllis A; Womack, Catherine; Hryshko-Mullen, Ann; Oh, John

    2015-08-01

    A higher proportion of military personnel than civilians smoke cigarettes. Few randomized trials of tobacco use interventions have been conducted in the U.S. military. We evaluated the efficacy of a tobacco quitline (QL) in 1298 active duty military personnel, their dependents, reservists, and retirees who smoke cigarettes. Participants were randomized to either a proactive (counselor-initiated) or reactive (participant-initiated) QL intervention for 8 weeks. The proactive condition included up to an 8-week supply of free nicotine replacement therapy, and the reactive condition included a 2-week supply. The primary outcome was 12-month smoking abstinence. The enrolled population was predominantly affiliated with the Air Force and Army. At the end of treatment, proactive treatment was associated with a greater odds of both prolonged (44.22% vs. 24.96%; odds ratio [OR] = 2.4, P < 0.0001) and 7-day point prevalence (49.92% vs. 28.20%; OR = 2.5, P < 0.0001) smoking abstinence, a difference that was maintained for prolonged smoking abstinence at 12 months (22.03% vs. 13.41%; OR = 1.8, P < 0.0001). Our findings provide evidence that a proactive QL with nicotine replacement therapy is highly efficacious among Air Force and Army active duty and TRICARE beneficiaries and would provide an effective telephonic treatment option for this population of smokers.

  2. Selective Early Retirement of Officers on an Active Duty List and the Reserve Active Status List and Selective Early Removal of Officers from the Reserve Active Status List,

    DTIC Science & Technology

    2007-11-02

    States Code, to update policies for the selective early retirement of commissioned officers and warrant officers from the Active Duty List, selective...early removal of commissioned officers from the Reserve Active Status List, and selective early retirement of officers in the Naval Reserve, serving in

  3. Heart rate variability characteristics in a large group of active-duty Marines and relationship to posttraumatic stress

    PubMed Central

    Minassian, Arpi; Geyer, Mark A.; Baker, Dewleen G.; Nievergelt, Caroline M.; O'Connor, Daniel T.; Risbrough, Victoria B.

    2014-01-01

    Objective Heart rate variability (HRV), thought to reflect autonomic nervous system function, is lowered in conditions such as posttraumatic stress disorder (PTSD). The potential confounding effects of traumatic brain injury (TBI) and depression in the relationship between HRV and PTSD have not been elucidated in a large cohort of military service members. Here we describe HRV associations with stress disorder symptoms in a large study of Marines, while accounting for well-known covariates of HRV and PTSD including TBI and depression. Methods Four battalions of male active-duty Marines (N=2430) were assessed 1-2 months prior to a combat deployment. HRV was measured during 5 minutes of rest. Depression and PTSD were assessed using the Beck Depression Inventory and Clinician Administered PTSD scale respectively. Results After accounting for covariates including TBI, a regression indicated that lower levels of high frequency (HF) HRV were associated with a diagnosis of PTSD (beta = -.20, p=.035). Depression and PTSD severity were correlated (r= .49, p <.001), however participants with PTSD but relatively low depression scores exhibited reduced HF compared to controls (p=.012). Marines with deployment experience (n=1254) had lower HRV than those with no experience (p = .033). Conclusions This cross-sectional analysis of a large cohort supports associations between PTSD and reduced HRV when accounting for TBI and depression symptoms. Future post-deployment assessments will be used to determine whether pre-deployment HRV can predict vulnerability and resilience to the serious psychological and physiological consequences of combat exposure. PMID:24804881

  4. Rationale for Spiritually Oriented Cognitive Processing Therapy for Moral Injury in Active Duty Military and Veterans With Posttraumatic Stress Disorder.

    PubMed

    Koenig, Harold G; Boucher, Nathan A; Oliver, Rev John P; Youssef, Nagy; Mooney, Scott R; Currier, Joseph M; Pearce, Michelle

    2017-02-01

    Wartime experiences have long been known to cause ethical conflict, guilt, self-condemnation, difficulty forgiving, loss of trust, lack of meaning and purpose, and spiritual struggles. "Moral injury" (MI) (also sometimes called "inner conflict") is the term used to capture this emotional, cognitive, and behavioral state. In this article, we provide rationale for developing and testing Spiritually Oriented Cognitive Processing Therapy, a version of standard cognitive processing therapy for the treatment of MI in active duty and veteran service members (SMs) with posttraumatic stress disorder symptoms who are spiritual or religious (S/R). Many SMs have S/R beliefs that could increase vulnerability to MI. Because the injury is to deeply held moral standards and ethical values and often adversely affects spiritual beliefs and worldview, we believe that those who are S/R will respond more favorably to a therapy that directly targets this injury from a spiritually oriented perspective. An evidence-based treatment for MI in posttraumatic stress disorder that not only respects but also utilizes SMs' spiritual beliefs/behaviors may open the door to treatment for many S/R military personnel.

  5. 77 FR 27542 - Agency Information Collection Activities (Bereaved Family Member Satisfaction Survey) Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... AFFAIRS Agency Information Collection Activities (Bereaved Family Member Satisfaction Survey) Under OMB... INFORMATION: Title: Bereaved Family Member Satisfaction Survey, VA Form 10- 21081(NR). OMB Control Number... VA Form 10-21081(NR) will be use to survey family members of deceased veterans on their...

  6. Health-related impact of deployment extensions on spouses of active duty army personnel.

    PubMed

    SteelFisher, Gillian K; Zaslavsky, Alan M; Blendon, Robert J

    2008-03-01

    This study examined problems pertaining to the health and well-being of Army spouses during deployment, comparing those whose experienced extensions of their partners' deployments with those whose partners returned home on time or early. It used data from a 2004 survey of 798 spouses of active duty personnel. Controlling for demographic and deployment characteristics, spouses who experienced extensions fared worse on an array of measures, including mental well-being (e.g., feelings of depression), household strains (e.g., problems with household and car maintenance), and some areas of their jobs (having to stop work or to work fewer hours). There were no statistically significant differences regarding problems pertaining to their overall health, marriage, other work issues, finances, relationships with Army families, or safety. However, spouses who experienced extensions were more likely to perceive the Army negatively during deployment. These findings suggest that deployment extensions may exacerbate certain problems and frustrations for Army spouses.

  7. Dental utilization by spouses of active duty U.S. military personnel.

    PubMed

    Chisick, M C; Poindexter, F R; York, A K

    1998-03-01

    This study explores dental utilization and access barriers to dental care for spouses of active duty U.S. military personnel as reported by their military sponsor. It also compares dental utilization of spouses and civilians. The data, collected using self-administered questionnaires between April 1994 and January 1995, are from 5,732 Army, Air Force, Navy, and Marine personnel with nonmilitary spouses. Comparative civilian data are from the most recent (1985-1986) U.S. oral health survey of working adults. Results show that dental utilization of military spouses parallels that of civilians. Cost was the most commonly cited barrier to dental care for spouses. Logistic regression results show that the likelihood of a spouse having seen a dentist within the past year is influenced by insurance status, sex, branch of service of sponsor, and rank of sponsor. Insurance status is the strongest predictor of dental utilization for spouses.

  8. Paralysis as a Presenting Symptom of Hyperthyroidism in an Active Duty Soldier.

    PubMed

    Jennette, John; Tauferner, Dustin

    2015-01-01

    Thyrotoxic periodic paralysis (TPP) is an endocrine disorder presenting with proximal motor weakness, typically greatest in the lower extremities, hypokalemia, and signs or laboratory findings consistent with hyperthyroidism. The incidence of TPP is highest in Asian males. This is a case report of a 30-year-old male active duty Soldier who presented to the emergency department complaining of several recent episodes of lower extremity paralysis. The patient underwent a workup which included serum and cerebrospinal fluid studies, and was found to be hypokalemic and hyperthyroid. Following consultation with neurology, the patient was admitted to the medicine service and treated for thyrotoxic periodic paralysis with potassium replacement and treatment of his hyperthyroidism. Since achieving a euthyroid state, he has had no recurrences of TPP. This disease should be considered in patients presenting with symmetric motor weakness and hypokalemia, whether or not symptoms of hyperthyroidism are elicited during the review of systems.

  9. Validity of the Virtual Reality Stroop Task (VRST) in active duty military.

    PubMed

    Armstrong, Christina M; Reger, Greg M; Edwards, Joseph; Rizzo, Albert A; Courtney, Christopher G; Parsons, Thomas D

    2013-01-01

    Virtual environments provide the ability to systematically deliver test stimuli in simulated contexts relevant to real world behavior. The current study evaluated the validity of the Virtual Reality Stroop Task (VRST), which presents test stimuli during a virtual reality military convoy with simulated combat threats. Active duty Army personnel (N = 49) took the VRST, a customized version of the Automated Neuropsychological Assessment Metrics (ANAM)-Fourth Edition TBI Battery (2007) that included the addition of the ANAM Stroop and Tower tests, and traditional neuropsychological measures, including the Delis-Kaplan Executive Function System version of the Color-Word Interference Test. Preliminary convergent and discriminant validity was established, and performance on the VRST was significantly associated with computerized and traditional tests of attention and executive functioning. Valid virtual reality cognitive assessments open new lines of inquiry into the impact of environmental stimuli on performance and offer promise for the future of neuropsychological assessments used with military personnel.

  10. 75 FR 78726 - Agency Information Collection Activities: North American Free Trade Agreement Duty Deferral

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... requirement concerning the North American Free Trade Agreement (NAFTA) Duty Deferral. This request for comment... soliciting comments concerning the following information collection: Title: NAFTA Duty Deferral. OMB Number: 1651-0071. Abstract: The provisions of North American Free Trade Agreement (NAFTA) were adopted by...

  11. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false The nature of the duties or activities to which the bonding... BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY BONDING RULES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  12. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false The nature of the duties or activities to which the bonding... BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY BONDING RULES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  13. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  14. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  15. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  16. They Self-Ignited: Adult Student Journeys to an Associate's Degree While Active Duty Military or Military Spouse

    ERIC Educational Resources Information Center

    Bibus, Lindsay Pohl

    2013-01-01

    This qualitative study was undertaken in order to gain an understanding of the lived experiences of adult students and how they made meaning of their journey. To that end, through in-depth interviews with twenty participants, the study inquired into the journeys to an associate's degree of adult students who were also active duty military service…

  17. A Multisite, Randomized Clinical Trial of Virtual Reality and Prolonged Exposure Therapy for Active Duty Soldiers with PTSD

    DTIC Science & Technology

    2015-02-01

    Therapy (PE) Post - Traumatic Stress Disorder (PTSD) Clinician-Administered PTSD Scale (CAPS) BODY: Overview This study was a randomized, waitlist...therapy (PE) with a waitlist (WL) group in the treatment of posttraumatic stress disorder (PTSD) in active duty (AD) Soldiers with combat-related...subjects randomized. 15. SUBJECT TERMS exposure therapy, posttraumatic stress disorder , virtual reality, military, prolonged exposure 16

  18. Functional Improvement Following Diastasis Rectus Abdominus Repair in an Active Duty Navy Female.

    PubMed

    Gallus, Katerina M; Golberg, Kathy F; Field, Robert

    2016-08-01

    Return to physical activity following childbirth can be a difficult process complicated by structural changes during pregnancy. A common problem is the development of a diastasis of the rectus abdominus (DRA), defined as a horizontal separation of the abdominus muscles at the linea alba. Recent data indicate that the greater the distance of separation of the muscle, the worse the functional ability. We describe a 24-year-old active duty U.S. Navy female G1P2 with a diagnosis of DRA. At 2 months postpartum, she was referred to physical therapy because of back pain and inability to meet baseline activities of daily living. After 4 months of physical therapy, she was unable to complete curl ups as required by U.S. Navy physical fitness standards. Abdominoplasty with imbrication of the abdominal wall diastasis was performed followed by additional physical therapy, after which she returned to baseline functioning. The restoration of functional ability postoperatively suggests there is a therapeutic indication for surgical correction of DRA. In high-functioning military patients with DRA who fail to return to baseline level of activity following a trial of physical therapy, surgical intervention should be considered to obtain the optimal functional ability.

  19. Development of an active member using piezoelectric and electrostrictive actuation for control of precision structures

    NASA Technical Reports Server (NTRS)

    Anderson, E. H.; Moore, D. M.; Fanson, J. L.; Ealey, M. A.

    1990-01-01

    The design and development of a zero stiction active member containing piezoelectric and electrostrictive actuator motors is presented. The active member is intended for use in submicron control of structures. Experimental results are shown which illustrate actuator and device characteristics relevant to precision control applications.

  20. Performance validity test and neuropsychological assessment battery screening module performances in an active-duty sample with a history of concussion.

    PubMed

    Grills, Chad E; Armistead-Jehle, Patrick

    2016-01-01

    The current retrospective investigation sought to replicate previous findings demonstrating the significant impact of performance validity test (PVT) performance and evaluation context on neuropsychological testing. We examined differences on performance validity testing between active-duty service members undergoing neurocognitive screening for concussion who were seen in a clinical context and those who were seen in a disability-seeking context, as well as the overall impact of PVT performance on a neurocognitive screening battery. Overall, 38.2% of the sample failed the Word Memory Test (WMT). Of those involved in a disability evaluation, the failure rate was 51.9%, which was significantly higher than the 36.8% failure rate among those evaluated in a clinical context. The effect size of WMT performance on a cognitive screening measure was also large. The current retrospective analysis served to replicate previous work.

  1. Understanding Militant Teacher Union Members' Activities in Secondary Schools

    ERIC Educational Resources Information Center

    Mahlangu, Vimbi P.

    2013-01-01

    This article investigates the activities of teacher unions in some Gauteng secondary schools in South Africa. The methods used in collecting data were questionnaires, interviews and a literature study of appropriate educational and labour law journals, books and newspapers. An interpretive paradigm was used in analysing the data. In this article,…

  2. Active member vibration control for a 4 meter primary reflector support structure

    NASA Technical Reports Server (NTRS)

    Umland, J. W.; Chen, G.-S.

    1992-01-01

    The design and testing of a new low voltage piezoelectric active member with integrated load cell and displacement sensor is described. This active member is intended for micron level vibration and structural shape control of the Precision Segmented Reflector test-bed. The test-bed is an erectable 4 meter diameter backup support truss for a 2.4 meter focal length parabolic reflector. Active damping of the test-bed is then demonstrated using the newly developed active members. The control technique used is referred to as bridge feedback. With this technique the internal sensors are used in a local feedback loop to match the active member's input impedance to the structure's load impedance, which then maximizes vibrational energy dissipation. The active damping effectiveness is then evaluated from closed loop frequency responses.

  3. 5 CFR 734.406 - Participation in political activities while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... while on duty, in uniform, in any room or building occupied in the discharge of official duties, or... on duty, in uniform, in any room or building occupied in the discharge of official duties, or using a... any room or building occupied in the discharge of official duties by an individual employed or...

  4. Analysis of heavy-duty diesel truck activity and emissions data

    NASA Astrophysics Data System (ADS)

    Huai, Tao; Shah, Sandip D.; Wayne Miller, J.; Younglove, Ted; Chernich, Donald J.; Ayala, Alberto

    Despite their relatively small population, heavy-duty diesel vehicles (HDDVs) are (in 2005) disproportionate contributors to the emissions inventory for oxides of nitrogen (NO x) and particulate matter (PM) due to their high individual vehicle emissions rates, lack of engine aftertreatment, and high vehicle miles traveled. Beginning in the early 1990s, heavy-duty engine manufacturers began equipping their engines with electronic sensors and controls and on-board electronic computer modules (ECMs) to manage these systems. These ECMs can collect and store both periodic and lifetime engine operation data for a variety of engine and vehicle parameters including engine speed and load, time at idle, average vehicle speed, etc. The University of California, Riverside (UCR), under a contract with the California Air Resources Board (CARB), performed data analysis of 270 ECM data sets obtained from the CARB. The results from this analysis have provided insights into engine/vehicle operation that have not been obtained from previous on-board datalogger studies since those previous studies focused on vehicle operation and did not collect engine operating data. Results indicate that HDDVs spend a considerable amount of time at high-speed cruise and at idle and that a smaller percentage of time is spent under transient engine/vehicle operation. These results are consistent with other HDDV activity studies, and provide further proof of the validity of assumptions in CARB's emission factor (EMFAC2002) model. An additional important contribution of this paper is that the evaluation of vehicle ECM data provides several advantages over traditional global positioning system (GPS) and datalogger studies: (1) ECM data is significantly cheaper than the traditional method (50 record -1 vs. ˜2000 record -1) and (2) ECM data covers vehicle operation over the entire life of the vehicle, whereas traditional surveys cover only short periods of surveillance (days, weeks, or months). It is

  5. A frequency-duty cycle equation for the ACGIH hand activity level.

    PubMed

    Radwin, Robert G; Azari, David P; Lindstrom, Mary J; Ulin, Sheryl S; Armstrong, Thomas J; Rempel, David

    2015-01-01

    A new equation for predicting the hand activity level (HAL) used in the American Conference for Government Industrial Hygienists threshold limit value®(TLV®) was based on exertion frequency (F) and percentage duty cycle (D). The TLV® includes a table for estimating HAL from F and D originating from data in Latko et al. (Latko WA, Armstrong TJ, Foulke JA, Herrin GD, Rabourn RA, Ulin SS, Development and evaluation of an observational method for assessing repetition in hand tasks. American Industrial Hygiene Association Journal, 58(4):278-285, 1997) and post hoc adjustments that include extrapolations outside of the data range. Multimedia video task analysis determined D for two additional jobs from Latko's study not in the original data-set, and a new nonlinear regression equation was developed to better fit the data and create a more accurate table. The equation, HAL = 6:56 ln D[F(1:31) /1+3:18 F(1:31), generally matches the TLV® HAL lookup table, and is a substantial improvement over the linear model, particularly for F>1.25 Hz and D>60% jobs. The equation more closely fits the data and applies the TLV® using a continuous function.

  6. A hand speed-duty cycle equation for estimating the ACGIH hand activity level rating.

    PubMed

    Akkas, Oguz; Azari, David P; Chen, Chia-Hsiung Eric; Hu, Yu Hen; Ulin, Sheryl S; Armstrong, Thomas J; Rempel, David; Radwin, Robert G

    2015-01-01

    An equation was developed for estimating hand activity level (HAL) directly from tracked root mean square (RMS) hand speed (S) and duty cycle (D). Table lookup, equation or marker-less video tracking can estimate HAL from motion/exertion frequency (F) and D. Since automatically estimating F is sometimes complex, HAL may be more readily assessed using S. Hands from 33 videos originally used for the HAL rating were tracked to estimate S, scaled relative to hand breadth (HB), and single-frame analysis was used to measure D. Since HBs were unknown, a Monte Carlo method was employed for iteratively estimating the regression coefficients from US Army anthropometry survey data. The equation: HAL = 10[e(-15:87+0:02D+2:25 ln S)/(1+e(-15:87+0:02D+2:25 ln S)], R(2) = 0.97, had a residual range ± 0.5 HAL. The S equation superiorly fits the Latko et al. ( 1997 ) data and predicted independently observed HAL values (Harris 2011) better (MSE = 0.16) than the F equation (MSE = 1.28).

  7. Motor vehicle crashes among active duty U.S. Army personnel, 1999 to 2006.

    PubMed

    Rossen, Lauren M; Pollack, Keshia M; Canham-Chervak, Michelle; Canada, Sara; Baker, Susan P

    2011-09-01

    In the U.S. Army, motor vehicle crashes (MVCs), both privately owned and military, are a leading cause of injury and death. Few studies have described the distribution and trends of MVCs among Army personnel, which may have been impacted by current military missions. This descriptive study of risk factors and select outcomes is from safety report data maintained by the U.S. Army Combat Readiness/Safety Center on 11,469 active duty Army personnel involved in MVCs, 1999-2006. The majority (66%) of Soldiers in MVCs were in military vehicles within the continental United States (68%). The average age of individuals involved in MVCs was 27.7 years old. Males had a consistently higher MVC rate than females. The average cost per MVC related to property damage and injuries was $36,039 and $24,038, respectively. Results suggest a need for additional exploration of MVCs involving Army vehicles, which were the most common and among the most costly.

  8. Prevalence and correlates of needle-stick injuries among active duty police officers in Tijuana, Mexico

    PubMed Central

    Mittal, María Luisa; Beletsky, Leo; Patiño, Efraín; Abramovitz, Daniela; Rocha, Teresita; Arredondo, Jaime; Bañuelos, Arnulfo; Rangel, Gudelia; Strathdee, Steffanie A

    2016-01-01

    Introduction Police officers are at an elevated risk for needle-stick injuries (NSI), which pose a serious and costly occupational health risk for HIV and viral hepatitis. However, research on NSIs among police officers is limited, especially in low- and middle-income countries. Despite the legality of syringe possession in Mexico, half of people who inject drugs (PWID) in Tijuana report extrajudicial syringe-related arrests and confiscation by police, which has been associated with needle-sharing and HIV infection. We assessed the prevalence and correlates of NSIs among Tijuana police officers to inform efforts to improve occupational safety and simultaneously reduce HIV risks among police and PWID. Methods Tijuana's Department of Municipal Public Safety (SSPM) is among Mexico's largest. Our binational, multi-sectoral team analyzed de-identified data from SSPM's 2014 anonymous self-administered occupational health survey. The prevalence of NSI and syringe disposal practices was determined. Logistic regression with robust variance estimation via generalized estimating equations identified factors associated with ever having an occupational NSI. Results Approximately one-quarter of the Tijuana police force was given the occupational health survey (N=503). Respondents were predominantly male (86.5%) and ≤35 years old (42.6%). Nearly one in six officers reported ever having a NSI while working at SSPM (15.3%), of whom 14.3% reported a NSI within the past year. Most participants reported encountering needles/syringes while on duty (n=473, 94%); factors independently associated with elevated odds of NSIs included frequently finding syringes that contain drugs (adjusted odds ratio (AOR): 2.98; 95% confidence interval (CI): 1.56–5.67) and breaking used needles (AOR: 2.25; 95% CI: 1.29–3.91), while protective factors included being willing to contact emergency services in case of NSIs (AOR: 0.39; 95% CI: 0.22–0.69), and wearing needle-stick resistant gloves (AOR: 0

  9. 20 CFR 404.1330 - Who is a member of a uniformed service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... individual who served on active duty after 1956. You are a member of a uniformed service if you— (a) Are... Reserve as a temporary member); (b) Served in the Army or Air Force under call or conscription; (c) Are a... United States Naval Academy; or (h) Are a member of the Reserve Officers Training Corps of the Army,...

  10. 26 CFR 1.112-1 - Combat zone compensation of members of the Armed Forces.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (and members of the Armed Forces are described) in section 7701(a)(15). (4) Military compensation only... States or by an international organization to a member of the Armed Forces whose military active duty... supplement the member's military compensation or is labeled by the employer as compensation for...

  11. 26 CFR 1.112-1 - Combat zone compensation of members of the Armed Forces.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (and members of the Armed Forces are described) in section 7701(a)(15). (4) Military compensation only... States or by an international organization to a member of the Armed Forces whose military active duty... supplement the member's military compensation or is labeled by the employer as compensation for...

  12. 26 CFR 1.112-1 - Combat zone compensation of members of the Armed Forces.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (and members of the Armed Forces are described) in section 7701(a)(15). (4) Military compensation only... States or by an international organization to a member of the Armed Forces whose military active duty... supplement the member's military compensation or is labeled by the employer as compensation for...

  13. 26 CFR 1.112-1 - Combat zone compensation of members of the Armed Forces.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (and members of the Armed Forces are described) in section 7701(a)(15). (4) Military compensation only... States or by an international organization to a member of the Armed Forces whose military active duty... supplement the member's military compensation or is labeled by the employer as compensation for...

  14. 26 CFR 1.112-1 - Combat zone compensation of members of the Armed Forces.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (and members of the Armed Forces are described) in section 7701(a)(15). (4) Military compensation only... States or by an international organization to a member of the Armed Forces whose military active duty... supplement the member's military compensation or is labeled by the employer as compensation for...

  15. Communist purges of Soviet Academy of Sciences members and solar activity

    NASA Astrophysics Data System (ADS)

    Tomilin, Konstantin A.

    The author is investigating the corelation between the intansity of Communsit purges under Members of the Academy of Sciences of USSR and Solar Activity, based on previous researches by Alexander Leonidovich Chizhevskij (1897-1964).

  16. Reference values for performance on the Automated Neuropsychological Assessment Metrics V3.0 in an active duty military sample.

    PubMed

    Reeves, Dennis L; Bleiberg, Joseph; Roebuck-Spencer, Tresa; Cernich, Alison N; Schwab, Karen; Ivins, Brian; Salazar, Andres M; Harvey, Sally C; Brown, Fred H; Warden, Deborah

    2006-10-01

    The Automated Neuropsychological Assessment Metrics (ANAM) is a computerized measure of processing speed, cognitive efficiency, and memory. This study describes performance and psychometric properties of ANAM in an active duty, healthy military sample (N = 2,371) composed primarily of young (18-46 years) adult males. Rarely have neuropsychological reference values for use with individuals in the military been derived from a large, active duty military population, and this is the first computerized neuropsychological test battery with military-specific reference values. Although these results do not provide demographically corrected, formal normative data, they provide reference points for neuropsychologists and other health care providers who are using ANAM data in research or clinical settings, with patients of comparable demographics to the present sample.

  17. Deployment stressors and posttraumatic stress symptomatology: comparing active duty and National Guard/Reserve personnel from Gulf War I.

    PubMed

    Vogt, Dawne S; Samper, Rita E; King, Daniel W; King, Lynda A; Martin, James A

    2008-02-01

    The increased use of National Guard and Reserve (NG/R) military personnel in current conflicts raises the question of whether deployment experiences and their associations with posttraumatic stress symptomatology differ for active duty and NG/R military personnel. To date, very few studies are available on this topic. Moreover, it is unclear whether the impact of military status differs for women and men. We addressed these research issues in a sample of 311 female and male Gulf War I veterans. Several differences were observed in deployment stressor exposures and results based on differential associations generally suggested more negative impacts of deployment experiences for active duty women and NG/R men. The potential role of unit cohesion in explaining these findings is discussed.

  18. Which Members of the Microbial Communities Are Active? Microarrays

    NASA Astrophysics Data System (ADS)

    Morris, Brandon E. L.

    only at the early stages of understanding the microbial processes that occur in petroliferous formations and the surrounding subterranean environment. Important first steps in characterising the microbiology of oilfield systems involve identifying the microbial community structure and determining how population diversity changes are affected by the overall geochemical and biological parameters of the system. This is relatively easy to do today by using general 16S rRNA primers for PCR and building clone libraries. For example, previous studies using molecular methods characterised many dominant prokaryotes in petroleum reservoirs (Orphan et al., 2000) and in two Alaskan North Slope oil facilities (Duncan et al., 2009; Pham et al., 2009). However, the problem is that more traditional molecular biology approaches, such as 16S clone libraries, fail to detect large portions of the community perhaps missing up to half of the biodiversity (see Hong et al., 2009) and require significant laboratory time to construct large libraries necessary to increase the probability of detecting the majority of even bacterial biodiversity. In the energy sector, the overarching desire would be to quickly assess the extent of in situ hydrocarbon biodegradation or to disrupt detrimental processes such as biofouling, and in these cases it may not be necessary to identify specific microbial species. Rather, it would be more critical to evaluate metabolic processes or monitor gene products that are implicated in the specific activity of interest. Research goals such as these are well suited for a tailored application of microarray technology.

  19. Association among functional-movement ability, fatigue, sedentary time, and fitness in 40 years and older active duty military personnel.

    PubMed

    Kennedy-Armbruster, Carol; Evans, Ellen M; Sexauer, Lisa; Peterson, James; Wyatt, William

    2013-12-01

    Identifying potential modifiable determinants of functional movement ability and fatigue may inform efforts to maintain constant physical readiness, especially in active duty military over 40 years of age, who are largely sedentary throughout their work day. The primary aim of this study was to determine the associations among conventional fitness measures (body composition, flexibility, and strength), sedentary behavior (sitting time), functional movement ability, and fatigue in military personnel. Volunteer active duty personnel 40 years of age and older (n = 569 males; n = 121 females; mean ± SD for total sample = 44.5 ± 4.1 years) were assessed for adiposity (%Fat), strength, flexibility, self-reported sitting time, perceived fatigue using the fatigue severity scale, and functional movement ability using the functional movement screening criteria. Greater flexibility was associated with better functional movement screening scores (r = 0.34, p < 0.05), and waist circumference and %Fat were inversely related to function (r = -0.26 and -0.21, p < 0.05). Furthermore, less sitting time (p < 0.001) was associated with less fatigue. Our data suggest that exercise training, reductions in daily sitting time, and weight management may be viable intervention targets to enhance functional movement ability and reduce fatigue in 40+ year old active duty military personnel.

  20. Associations between dimensions of anxiety sensitivity and PTSD symptom clusters in active-duty police officers.

    PubMed

    Asmundson, Gordon J G; Stapleton, Jennifer A

    2008-01-01

    Prior studies have shown that anxiety sensitivity (AS) plays an important role in posttraumatic stress disorder (PTSD) symptom severity. The purpose of this study was to evaluate associations between empirically supported PTSD symptom clusters (i.e. reexperiencing, avoidance, numbing, hyperarousal) and AS dimensions (i.e. psychological concerns, social concerns, somatic concerns). Participants were 138 active-duty police officers (70.7% female; mean age = 38.9 years; mean time policing = 173.8 months) who, as a part of a larger study, completed measures of trauma exposure, PTSD symptoms, AS, and depressive symptoms. All participants reported experiencing at least one event that they perceived as traumatic, and 44 (31.9%) screened positive for PTSD. Officers with probable PTSD scored significantly higher on AS total as well as the somatic and psychological concerns dimensional scores than did those without PTSD. As well, a higher percentage of officers with probable PTSD scored positively on the AS-derived Brief Screen for Panic Disorder (Apfeldorf et al., 1994) compared with those without PTSD. A series of regression analyses revealed that depressive symptoms, number of reported traumas, and AS somatic concerns were significant predictors of PTSD total symptom severity as well as severity of reexperiencing. Avoidance was predicted by depressive symptoms and AS somatic concerns. Only depressive symptoms were significantly predictive of numbing and hyperarousal cluster scores. These findings contribute to understanding the nature of association between AS and PTSD symptom clusters. Implications for the treatment of individuals having PTSD with and without panic-related symptomatology are discussed.

  1. 77 FR 73038 - Agency Information Collection Activities: Application for Allowance in Duties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... the Application for Allowance in Duties (CBP Form 4315). This request for comment is being made... of other forms of information technology; and (e) the annual cost burden to respondents or record... Management and Budget (OMB) approval. All comments will become a matter of public record. In this...

  2. HEAVY DUTY DIESEL VEHICLE LOAD ESTIMATION: DEVELOPMENT OF VEHICLE ACTIVITY OPTIMIZATION ALGORITHM

    EPA Science Inventory

    The Heavy-Duty Vehicle Modal Emission Model (HDDV-MEM) developed by the Georgia Institute of Technology(Georgia Tech) has a capability to model link-specific second-by-second emissions using speed/accleration matrices. To estimate emissions, engine power demand calculated usin...

  3. Occupational Impact of Multilevel Cervical Disease Treated With Hybrid Cervical Disc Arthroplasty in Active Duty Military Population.

    PubMed

    Cleveland, Andrew; Herzog, Josh; Caram, Pedro

    2016-01-01

    This article evaluates the techniques, results, and complications of hybrid cervical disc arthroplasty in a high-demand military population. Emphasis is on the occupational impact and return to duty outcomes. This article is a case series with prospective follow-up of 30 hybrid cervical disc arthroplasty patients from the authors' institution. Average follow-up was 16.1 months. Average patient age was 39.7 years. Noncommissioned officer was the most common military rank. Cervical disc arthroplasty at C5/6 with fusion at C6/7 was the most common procedure (21/30). All classifications of military occupational specialty were represented. A total of 24/30 (80%) patients returned to duty (RTD) and 24/24 (100%) of RTD patients reported relief (postoperative improvement) compared with 4/6 (66.7%) medical evaluation board patients. Average RTD time was 15.6 weeks. All RTD patients maintained their preoperative military occupational specialty. Hybrid cervical disc arthroplasty has the potential to provide relief and return military patients to preoperative active duty status.

  4. 12 CFR 211.4 - Permissible activities and investments of foreign branches of member banks.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Operations of U.S. Banking Organizations § 211.4 Permissible activities and investments of foreign branches... 12 Banks and Banking 2 2011-01-01 2011-01-01 false Permissible activities and investments of foreign branches of member banks. 211.4 Section 211.4 Banks and Banking FEDERAL RESERVE SYSTEM BOARD...

  5. 12 CFR 211.4 - Permissible activities and investments of foreign branches of member banks.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Operations of U.S. Banking Organizations § 211.4 Permissible activities and investments of foreign branches... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Permissible activities and investments of foreign branches of member banks. 211.4 Section 211.4 Banks and Banking FEDERAL RESERVE SYSTEM BOARD...

  6. Evaluation of doctoral nursing programs in Japan by faculty members and their educational and research activities.

    PubMed

    Arimoto, Azusa; Gregg, Misuzu F; Nagata, Satoko; Miki, Yuko; Murashima, Sachiyo

    2012-07-01

    Evaluation of doctoral programs in nursing is becoming more important with the rapid increase in the programs in Japan. This study aimed to evaluate doctoral nursing programs by faculty members and to analyze the relationship of the evaluation with educational and research activities of faculty members in Japan. Target settings were all 46 doctoral nursing programs. Eighty-five faculty members from 28 programs answered the questionnaire, which included 17 items for program evaluation, 12 items for faculty evaluation, 9 items for resource evaluation, 3 items for overall evaluations, and educational and research activities. A majority gave low evaluations for sources of funding, the number of faculty members and support staff, and administrative systems. Faculty members who financially supported a greater number of students gave a higher evaluation for extramural funding support, publication, provision of diverse learning experiences, time of supervision, and research infrastructure. The more time a faculty member spent on advising doctoral students, the higher were their evaluations on the supportive learning environment, administrative systems, time of supervision, and timely feedback on students' research. The findings of this study indicate a need for improvement in research infrastructure, funding sources, and human resources to achieve quality nursing doctoral education in Japan.

  7. Active member vibration control experiment in a KC-135 reduced gravity environment

    NASA Technical Reports Server (NTRS)

    Lawrence, C. R.; Lurie, B. J.; Chen, G.-S.; Swanson, A. D.

    1991-01-01

    An active member vibration control experiment in a KC-135 reduced gravity environment was carried out by the Air Force Flight Dynamics Laboratory and the Jet Propulsion Laboratory. Two active members, consisting of piezoelectric actuators, displacement sensors, and load cells, were incorporated into a 12-meter, 104 kg box-type test structure. The active member control design involved the use of bridge (compound) feedback concept, in which the collocated force and velocity signals are feedback locally. An impact-type test was designed to accommodate the extremely short duration of the reduced gravity testing window in each parabolic flight. The moving block analysis technique was used to estimate the modal frequencies and dampings from the free-decay responses. A broadband damping performance was demonstrated up to the ninth mode of 40 Hz. The best damping performance achieved in the flight test was about 5 percent in the fourth mode of the test structure.

  8. Multiple Past Concussions Are Associated with Ongoing Post-Concussive Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers.

    PubMed

    Dretsch, Michael N; Silverberg, Noah D; Iverson, Grant L

    2015-09-01

    The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs(®)) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.

  9. An Uncharacterized Member of the Ribokinase Family in Thermococcus kodakarensis Exhibits myo-Inositol Kinase Activity*

    PubMed Central

    Sato, Takaaki; Fujihashi, Masahiro; Miyamoto, Yukika; Kuwata, Keiko; Kusaka, Eriko; Fujita, Haruo; Miki, Kunio; Atomi, Haruyuki

    2013-01-01

    Here we performed structural and biochemical analyses on the TK2285 gene product, an uncharacterized protein annotated as a member of the ribokinase family, from the hyperthermophilic archaeon Thermococcus kodakarensis. The three-dimensional structure of the TK2285 protein resembled those of previously characterized members of the ribokinase family including ribokinase, adenosine kinase, and phosphofructokinase. Conserved residues characteristic of this protein family were located in a cleft of the TK2285 protein as in other members whose structures have been determined. We thus examined the kinase activity of the TK2285 protein toward various sugars recognized by well characterized ribokinase family members. Although activity with sugar phosphates and nucleosides was not detected, kinase activity was observed toward d-allose, d-lyxose, d-tagatose, d-talose, d-xylose, and d-xylulose. Kinetic analyses with the six sugar substrates revealed high Km values, suggesting that they were not the true physiological substrates. By examining activity toward amino sugars, sugar alcohols, and disaccharides, we found that the TK2285 protein exhibited prominent kinase activity toward myo-inositol. Kinetic analyses with myo-inositol revealed a greater kcat and much lower Km value than those obtained with the monosaccharides, resulting in over a 2,000-fold increase in kcat/Km values. TK2285 homologs are distributed among members of Thermococcales, and in most species, the gene is positioned close to a myo-inositol monophosphate synthase gene. Our results suggest the presence of a novel subfamily of the ribokinase family whose members are present in Archaea and recognize myo-inositol as a substrate. PMID:23737529

  10. Precipitating circumstances of suicide among active duty U.S. Army personnel versus U.S. civilians, 2005-2010.

    PubMed

    Logan, Joseph E; Skopp, Nancy A; Reger, Mark A; Gladden, Matt; Smolenski, Derek J; Floyd, C Faye; Gahm, Gregory A

    2015-02-01

    To help understand suicide among soldiers, we compared suicide events between active duty U.S. Army versus civilian decedents to identify differences and inform military prevention efforts. We linked 141 Army suicide records from 2005 to 2010 to National Violent Death Reporting System (NVDRS) data. We described the decedents' military background and compared their precipitators of death captured in NVDRS to those of demographically matched civilian suicide decedents. Both groups commonly had mental health and intimate partner precipitating circumstances, but soldier decedents less commonly disclosed suicide intent.

  11. Precipitating Circumstances of Suicide among Active Duty U.S. Army Personnel Versus U.S. Civilians, 2005–2010

    PubMed Central

    Logan, Joseph E; Skopp, Nancy A; Reger, Mark A; Gladden, Matt; Smolenski, Derek J; Floyd, C Faye; Gahm, Gregory A

    2015-01-01

    To help understand suicide among soldiers, we compared suicide events between active duty U.S. Army versus civilian decedents to identify differences and inform military prevention efforts. We linked 141 Army suicide records from 2005 to 2010 to National Violent Death Reporting System (NVDRS) data. We described the decedents’ military background and compared their precipitators of death captured in NVDRS to those of demographically matched civilian suicide decedents. Both groups commonly had mental health and intimate partner precipitating circumstances, but soldier decedents less commonly disclosed suicide intent. PMID:25093259

  12. Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers with and without PTSD

    DTIC Science & Technology

    2015-10-01

    Substance Abuse Program (ASAP) at Madigan Health Care System/Joint Base Lewis McChord. The aims of this trial are 1) to determine prazosin’s efficacy... Abuse Program (ASAP) at Madigan HCS/Joint Base Lewis McChord. The aims of this trial are 1) to determine prazosin’s efficacy for AUD in OIF/OEF soldiers...Augmentation of Outpatient Treatment of AUD in Active Duty Soldiers with and without PTSD. Presented at Joint Army/NIH Substance Abuse IP – September 29

  13. Wireless structural health monitoring for critical members of civil infrastructures using piezoelectric active sensors

    NASA Astrophysics Data System (ADS)

    Park, Seunghee; Yun, Chung-Bang; Inman, Daniel J.; Park, Gyuhae

    2008-03-01

    This paper presents several challenging issues on wireless structural health monitoring techniques for critical members of civil infrastructures using piezoelectric active sensors. The basic concept of the techniques is to monitor remotely the structural integrity by observing the impedance variations at the piezoelectric active sensors distributed to critical members of a host structure. An active sensing node incorporating on-board microprocessor and radio frequency telemetry is introduced in a sense of tailoring wireless sensing technology to the impedance method. A data compression algorithm using principal component analysis is embedded into the on-board chip of the active sensing node. The data compression algorithm would promote efficiency in terms of both power management and noise elimination of the active sensor node. Finally, a piezoelectric sensor self-diagnosis issue is touched introducing a new impedance model equation that incorporates the effects of sensor and bonding defects.

  14. Contribution of transition metals in the reactive oxygen species activity of PM emissions from retrofitted heavy-duty vehicles

    NASA Astrophysics Data System (ADS)

    Verma, Vishal; Shafer, Martin M.; Schauer, James J.; Sioutas, Constantinos

    2010-12-01

    We assessed the contribution of water-soluble transition metals to the reactive oxygen species (ROS) activity of diesel exhaust particles (DEPs) from four heavy-duty vehicles in five retrofitted configurations (V-SCRT, Z-SCRT, DPX, hybrid, and school bus). A heavy-duty truck without any control device served as the baseline vehicle. Particles were collected from all vehicle-configurations on a chassis dynamometer under three driving conditions: cruise (80 km h -1), transient UDDS, and idle. A sensitive macrophage-based in vitro assay was used to determine the ROS activity of collected particles. The contribution of water-soluble transition metals in the measured activity was quantified by their removal using a Chelex ® complexation method. The study demonstrates that despite an increase in the intrinsic ROS activity (per mass basis) of exhaust PM with use of most control technologies, the overall ROS activity (expressed per km or per h) was substantially reduced for retrofitted configurations compared to the baseline vehicle. Chelex treatment of DEPs water extracts removed a substantial (≥70%) and fairly consistent fraction of the ROS activity, which ascertains the dominant role of water-soluble metals in PM-induced cellular oxidative stress. However, relatively lower removal of the activity in few vehicle-configurations (V-SCRT, DPX and school bus idle), despite a large aggregate metals removal, indicated that not all species were associated with the measured activity. A univariate regression analysis identified several transition metals (Fe, Cr, Co and Mn) as significantly correlated ( R > 0.60; p < 0.05) with the ROS activity. Multivariate linear regression model incorporating Fe, Cr and Co explained 90% of variability in ROS levels, with Fe accounting for the highest (84%) fraction of the variance.

  15. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  16. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  17. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  18. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  19. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  20. Perceived Environmental Church Support and Physical Activity among Black Church Members

    ERIC Educational Resources Information Center

    Baruth, Meghan; Wilcox, Sara; Saunders, Ruth P.; Hooker, Steven P.; Hussey, James R.; Blair, Steven N.

    2013-01-01

    Background: Churches are an appealing setting for implementing health-related behavior change programs. Purpose: The objective of the study was to examine the relationship between perceived environmental church support for physical activity (PA) and PA behaviors. Method: Black church members from South Carolina ("n" = 309) wore an…

  1. Mutualistic Benefits Generate an Unequal Distribution of Risky Activities Among Unrelated Group Members

    NASA Astrophysics Data System (ADS)

    Kukuk, Penelope F.; Ward, Seamus A.; Jozwiak, Amy

    Recent studies provide a new challenge to the adequacy of theories concerning the evolution of cooperation among nonrelatives: some individuals perform high-risk activities while others do not. We examined a communal hymenopteran species, Lasioglossum(Chilalictus)hemichalceum, to determine why group members engaged in demonstrably risky activities (foraging) tolerate the selfish behavior (remaining in the nest) of unrelated nestmates. Experimental removal of adult females indicated that their presence is required for the protection of brood from ant predators. Nonforagers ensure the continued presence of adults in the nest if the risk-taking foragers die, thereby safeguarding the survival of forager offspring. This results in an unequal distribution of risky activities within social groups in which avoidance of risky activities by some group members is ultimately beneficial to risk takers.

  2. A Meta-Analysis of the Antecedents of Voluntary Turnover in Studies Involving Active Duty Military Member Populations

    DTIC Science & Technology

    2011-06-01

    subordinate outcomes Brown III, G. B. DTIC 2008 Y N A Pending Major Crisis : An Analysis of the Critical Shortage of U.S. Army Officers in Year Groups 1991...States Army Reserve McConico, J. L. DTIC 2009 Y N Ethical Imbalance: How the U.S. Army Overcame its Manning Crisis McDonald, G. K. DTIC 2007 Y Y Work...Characteristics From Multiple Data Sources With Employee Affect, Absence, Turnover Intentions, and Helth Spector, P. E., Dwyer, D. J., & Jex, S. M. JoAP 1988 N N

  3. A Study to Design a System to Identify Handicapped Family Members of Active Duty Soldiers at Fort Benning, Georgia

    DTIC Science & Technology

    1982-05-01

    REPORT 2b. DECLASSIFICATION /DOWNGRADING SCHEDULE Approved for public release; Distribution unlimited 4. PERFORMING ORGANIZATION REPORT NUMBER(S) S...MONITORING ORGANIZATION REPORT NUMBER(S) 104-88 6. NAME OF PERFORMING ORGANIZATION 6b. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATIONS rmy-aylo...Ft. Sam Houston, TX 78234-6100 Sa. NAME OF FUNDING/SPONSORING 8b. OFFICE SYMBOL 9. PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (If

  4. Economic Analysis of a Basic Allowance for Health Care for Active Duty and Retired Members of the Armed Forces

    DTIC Science & Technology

    2014-12-01

    support throughout the entire process . xvi THIS PAGE INTENTIONALLY LEFT BLANK 1 I. INTRODUCTION A. MILITARY HEALTH CARE SYSTEM Since the... process . Because funds are allowed to accumulate over time in the HSA, and ultimately transfer with the individual when he or she departs the service...CARE Money for DOD health care is appropriated through the Planning, Programming, Budgeting and Execution process . The Unified Military Health System

  5. Mental Health and Substance Use Factors Associated with Unwanted Sexual Contact among U.S. Active Duty Service Women

    PubMed Central

    Stahlman, Shauna; Javanbakht, Marjan; Cochran, Susan; Hamilton, Alison B.; Shoptaw, Steven; Gorbach, Pamina M.

    2015-01-01

    Many U.S. military women are exposed to unwanted sexual contact during military service, which can have important implications for mental health. Using data from the 2008 Department of Defense Survey of Health Related Behaviors, we employed multiple logistic regression methods to examine whether unwanted sexual contact was associated with stress, screening positive for mental disorders, or substance use, among active duty service women. The sample included 7,415 female military personnel, of whom 13.4% reported unwanted sexual contact (including any touching of genitals) since entering the military. After adjusting for potentially confounding variables, factors independently associated with unwanted sexual contact included military-related stress (Adjusted Odds Ratio [AOR] = 2.44), family/personal life-related stress (AOR = 1.78), and gender-related stress (AOR = 1.98) in the past 12 months. In addition, screening positive for depression, anxiety, posttraumatic stress disorder, psychological distress, and suicidal ideation or attempt were associated with unwanted sexual contact (AOR = 1.57–2.11). For drug/alcohol use, only misuse of tranquilizers/muscle relaxers (past 12 months) was associated with report of unwanted sexual contact (AOR = 1.35). Given the prevalence of unwanted sexual contact and corresponding adverse health outcomes in this sample of active duty women, strategies to create military structural/cultural changes and reduce gender-related stress and sexism are needed. PMID:25976935

  6. Mood symptoms contribute to working memory decrement in active-duty soldiers being treated for posttraumatic stress disorder

    PubMed Central

    Dretsch, Michael N; Thiel, Kenneth J; Athy, Jeremy R; Irvin, Clinton R; Sirmon-Fjordbak, Bess; Salvatore, Anthony

    2012-01-01

    A significant proportion of military veterans of operations in Afghanistan and Iraq have been diagnosed with posttraumatic stress disorder (PTSD). Growing evidence suggests that neuropsychological deficits are a symptom of PTSD. The current study investigated neurocognitive functioning among soldiers diagnosed with PTSD. Specifically, active-duty soldiers with and without a diagnosis of PTSD were assessed for performance on tests of attention and working memory. In addition, factors such as combat experience, depression, anxiety, PTSD symptom severity, and alcohol consumption were explored as possible mediators of group differences in neurocognitive functioning. Twenty-three active-duty soldiers diagnosed with PTSD were matched with 23 healthy Soldier controls; all were administered the Attention Network Task (ANT), Backward Digit Span (BDS) task, Beck Depression Inventory, Beck Anxiety Inventory, PTSD Checklist—Military Version, Combat Exposure Scale, and Modified Drinking Behavior Questionnaire. Soldiers diagnosed with PTSD performed significantly worse on the working memory task (BDS) than healthy controls, and reported greater levels of PTSD symptoms, combat exposure, depression, and anxiety. However, after controlling for depression and anxiety symptoms, the relationship between PTSD and working memory was no longer present. The results indicate that PTSD is accompanied by deficits in working memory, which appear to be partially attributed to anxiety and depression symptoms. PMID:22950039

  7. Repeat infection with Neisseria gonorrhoeae among active duty U.S. Army personnel: a population-based case-series study.

    PubMed

    Bautista, Christian T; Wurapa, Eyako K; Sateren, Warren B; Morris, Sara M; Hollingsworth, Bruce P; Sanchez, Jose L

    2016-11-24

    Little information is known on the rate of repeat gonorrhea infection among U.S. military personnel. We analyzed all gonorrhea cases reported to the Defense Medical Surveillance System during 2006-2012 to determine the rate of repeat infection. During the seven-year study period, 17,602 active duty U.S. Army personnel with a first incident gonorrhea infection were reported. Among the 4987 women with a first gonorrhea infection, 14.4% had at least one repeat infection. Among the 12,615 men with a first gonorrhea infection, 13.7% had at least one repeat infection. Overall, the rate of repeat gonorrhea infection was 44.5 and 48.9 per 1000 person-years for women and men, respectively. Service members aged 17-19 years (hazard ratio [HR] for women = 1.51; HR for men = 1.71), African-American personnel (HR for women = 1.26; HR for men = 2.17), junior enlisted personnel (HR for women = 2.64; HR for men = 1.37), and those with one year or less of service (HR for women = 1.23; HR for men = 1.37) were at higher risk of repeat infection. The findings from this study highlight the need to develop targeted prevention initiatives including education, counseling, and retesting to prevent gonorrhea reinfections among U.S. Army personnel.

  8. In-vitro activities of 14-, 15- and 16-membered macrolides against gram-positive cocci.

    PubMed

    Hamilton-Miller, J M

    1992-02-01

    The in-vitro activities of the 14-membered macrolides erythromycin, dirithromycin, roxithromycin, clarithromycin, the 15-membered compound azithromycin and the 16-membered macrolides (16 MM) josamycin, spiramycin and midecamycin acetate (MOM) have been compared against staphylococci, enterococci and streptococci. Results have been analysed separately according to the sensitivity status of the tested strains to erythromycin, namely sensitive (S), inducibly resistant (IR) or constitutively resistant (CR). 14- and 15-membered macrolides were active only against S strains; the order of potency in vitro was clarithromycin = erythromycin greater than azithromycin = roxithromycin greater than dirithromycin. The 16 MM were slightly less active against S strains than were the 14- and 15-membered compounds, and inhibited most IR strains; MOM and josamycin were about twice as potent as spiramycin. IR and S Staphylococcus aureus strains were equally sensitive to 16 MM, while IR strains of coagulase-negative staphylococci were less sensitive than were S strains. All CR strains of S. aureus were resistant to 16 MM, as were most of the other CR strains. However, 5/21 CR coagulase-negative staphylococci and 2/20 CR enterococci tested were sensitive to 16 MM. The seven CR strains showing anomalous sensitivity to the 16 MM (five Staphylococcus haemolyticus and two enterococci) were only 'moderately resistant' to erythromycin (MIC 8-64 mg/L), while all the other CR strains were 'highly resistant' (MIC greater than 128 mg/L). These results indicate that it may be difficult to predict the sensitivity of Gram-positive cocci to 16 MM, and therefore individual sensitivity testing to specific compounds is essential.

  9. LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway

    SciTech Connect

    Nadiminty, Nagalakshmi; Chun, Jae Yeon; Hu, Yan; Dutt, Smitha; Lin, Xin; Gao, Allen C. . E-mail: allen.gao@roswellpark.org

    2007-07-27

    Stat3, a member of the signal transducers and activators of transcription (STAT) family, is a key signal transduction protein activated by numerous cytokines, growth factors, and oncoproteins that controls cell proliferation, differentiation, development, survival, and inflammation. Constitutive activation of Stat3 has been found frequently in a wide variety of human tumors and induces cellular transformation and tumor formation. In this study, we demonstrated that LIGHT, a member of tumor necrosis factor superfamily, activates Stat3 in cancer cells. LIGHT induces dose-dependent activation of Stat3 by phosphorylation at both the tyrosine 705 and serine 727 residues. The activation of Stat3 by LIGHT appears to be mediated by NIK phosphorylation. Expression of a kinase-inactive NIK mutant abolished LIGHT induced Stat3 activation. Overexpression of an active NIK induces Stat3 activation by phosphorylation at the both tyrosine 705 and serine 727 residues. Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays. In addition, LIGHT increases the expression of Stat3 target genes including cyclin D1, survivin, and Bcl-xL, and stimulates human LNCaP prostate cancer cell growth in vitro which can be blocked by expression of a dominant-negative Stat3 mutant. Taken together, these results indicate that in addition to activating NF-{kappa}B/p52, LIGHT also activates Stat3. Activation of Stat3 together with activating non-canonical NF-{kappa}B/p52 signaling by LIGHT may maximize its effects on cellular proliferation, survival, and inflammation.

  10. A Monetary Repayment Model for Recoupment of the Educational Costs of Air Force Sponsored Graduate Education in Lieu of Completion of an Active Duty Service Commitment.

    ERIC Educational Resources Information Center

    Mangold, Sanford Dangler

    The study develops a model which enables the Air Force to initiate recoupment action against any officer, who is separating from active service prior to the completion of a graduate education Active Duty Service Commitment (ADSC). It is set up to determine the amount of money owed by the early existing officer, at any point in the ADSC. The…

  11. An Analysis of the Role of Service Specific Risk Factors in Active Duty Navy Suicides

    DTIC Science & Technology

    2014-03-01

    manic - depressives , and consumers of alcohol. They draw no independent associations between military service characteristics and suicide risk (LeardMann...current and prior military members. Using Cox models for survival analysis, they find the highest suicidal correlations with males, depressives ...factors for suicide: depression , past psychiatric treatment, anxiety, alcohol abuse, and guilty/shameful disposition. They execute a Poisson model to

  12. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission...

  13. Military unit support, postdeployment social support, and PTSD symptoms among active duty and National Guard soldiers deployed to Iraq.

    PubMed

    Han, Sohyun C; Castro, Frank; Lee, Lewina O; Charney, Meredith E; Marx, Brian P; Brailey, Kevin; Proctor, Susan P; Vasterling, Jennifer J

    2014-06-01

    Research suggests that military unit support and community postdeployment social support are associated with fewer PTSD symptoms following military deployment. This study extended prior research by examining the associations among predeployment unit support and PTSD symptoms before Iraq deployment as well as unit support, PTSD symptoms, and postdeployment social support after deployment among 835 U.S. Army and 173 National Guard soldiers. Multiple regression analyses indicated that predeployment unit support was not significantly associated with postdeployment PTSD severity in either group of soldiers, whereas higher unit support during deployment was significantly associated with lower postdeployment PTSD severity among active duty soldiers only. Among both groups, higher levels of postdeployment social support were associated with lower levels of postdeployment PTSD symptom severity. These findings suggest that postdeployment social support is a particularly strong buffer against postdeployment PTSD symptoms among both groups of soldiers whereas the effects of unit support may be limited.

  14. Supplemental genistein, quercetin, and resveratrol intake in active duty army soldiers.

    PubMed

    Sepowitz, John J; Fauser, Kristina R; Meyer, Stephanie A; Jackson, Steven J

    2015-05-01

    Previous reports indicate that the majority of U.S. Army soldiers consume dietary supplements (DSs) > 1 time/wk. However, these studies did not evaluate phytonutrient supplementation. A growing literature suggests inclusion of phytonutrients in DSs may pose a risk for toxicity, which could impact the performance of soldier duties, as well as long-term health and wellness. This study was conducted to assess and understand soldiers' motivations to consume phytonutrient-containing DSs, specifically genistein, quercetin, and resveratrol. The study was a cross-sectional, descriptive mixed-methods design using a survey and semistructured interviews. There were 436 soldiers stationed at Joint Base Lewis-McChord, Washington who completed the survey, from which 36 soldiers completed an interview. Overall, 34% of soldiers reported taking a single or multicomponent phytonutrient DS > 1 time/wk, from which 41 soldiers took >1 supplement/wk. Soldiers' reasons for use included unsure (54%), weight loss (12%), and other, unspecified (24%). The majority of interviewees did not consume DSs based on inclusion of genistein, quercetin, or resveratrol. The majority of soldiers, in our study, appear unable to rationalize their phytonutrient DS choices. Findings from this study illuminate the need for future research to further explore DS practices within military populations and encourage informed use of DSs.

  15. Active Duty - U.S. Army Noise Induced Hearing Injury Surveillance, Calendar Years 2007-2011

    DTIC Science & Technology

    2013-01-01

    summary for calendar years (CY) 2007-2011 showed increasing incidence rates for sensorineural hearing loss (SNHL), tinnitus , and significant threshold...induced hearing loss (NIHL) and tinnitus among U.S. military members from World War II through 2005. The report’s authors concluded that military hearing...epidemiological data to reliably estimate the incidence of NIHL and tinnitus in the U.S. Armed Forces. In response to the IOM report, military audiologists

  16. Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity.

    PubMed

    Al Khamici, Heba; Brown, Louise J; Hossain, Khondker R; Hudson, Amanda L; Sinclair-Burton, Alxcia A; Ng, Jane Phui Mun; Daniel, Elizabeth L; Hare, Joanna E; Cornell, Bruce A; Curmi, Paul M G; Davey, Mary W; Valenzuela, Stella M

    2015-01-01

    The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins where they function as chloride selective ion channels, however no function has previously been assigned to their soluble form. Structural studies have shown that in the soluble form, CLIC proteins adopt a glutathione S-transferase (GST) fold, however, they have an active site with a conserved glutaredoxin monothiol motif, similar to the omega class GSTs. We demonstrate that CLIC proteins have glutaredoxin-like glutathione-dependent oxidoreductase enzymatic activity. CLICs 1, 2 and 4 demonstrate typical glutaredoxin-like activity using 2-hydroxyethyl disulfide as a substrate. Mutagenesis experiments identify cysteine 24 as the catalytic cysteine residue in CLIC1, which is consistent with its structure. CLIC1 was shown to reduce sodium selenite and dehydroascorbate in a glutathione-dependent manner. Previous electrophysiological studies have shown that the drugs IAA-94 and A9C specifically block CLIC channel activity. These same compounds inhibit CLIC1 oxidoreductase activity. This work for the first time assigns a functional activity to the soluble form of the CLIC proteins. Our results demonstrate that the soluble form of the CLIC proteins has an enzymatic activity that is distinct from the channel activity of their integral membrane form. This CLIC enzymatic activity may be important for protecting the intracellular environment against oxidation. It is also likely that this enzymatic activity regulates the CLIC ion channel function.

  17. 5 CFR 734.306 - Participation in political activities while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... form of another employee, to the payroll employees who would process or administer such forms. However... using a Federal vehicle. 734.306 Section 734.306 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... employee is on duty and continues into the time when he or she is not on duty, the employee must wait...

  18. Students Help a Teacher Called to Active Duty: What a Great Feeling to Have a Group of Students Who Are Excited and Want to Help a Teacher in Need so Many Miles from Home

    ERIC Educational Resources Information Center

    Yuill, Ron

    2005-01-01

    The author shares how his technology education students at Tecumseh Middle School help his former student from a Purdue class, Ryan Smith, who was called to active military duty. Ryan was teaching technology education at Lafayette Jefferson High School when he was called by the military in the fall of 2004 to report to active duty. Before…

  19. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time limitation? 302-2.9 Section 302-2.9 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules Time Limits §...

  20. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time limitation? 302-2.9 Section 302-2.9 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules Time Limits §...

  1. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time limitation? 302-2.9 Section 302-2.9 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules Time Limits §...

  2. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time limitation? 302-2.9 Section 302-2.9 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules Time Limits §...

  3. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time limitation? 302-2.9 Section 302-2.9 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS General Rules Time Limits §...

  4. Pilot Study to determine interest of adult civilian dependants of active duty military personnel in participation in a weight control program

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Adult civilian dependents of active duty military personnel (ADMP) may play a central role in influencing the home food environment and the risk of overweight and obesity in American Warfighters and military families. However, there is no information on whether this group would be receptive to weigh...

  5. The Effect of Career Assessments and Follow-Up Counseling on Career Decision-Making Self-Efficacy (CDMSE) among Active-Duty Coast Guard Personnel

    ERIC Educational Resources Information Center

    Brennan, Michael D.

    2009-01-01

    This study (a) examined career decision-making self-efficacy (CDMSE) differences across gender, age, military grade, level of education, previous career assessments, previous career counseling, and currently attending college, and (b) examined the effect of career assessments with follow-up counseling on CDMSE among active-duty Coast Guard…

  6. A Military Campaign Against Gangs: Internal Security Operations in the United States by Active Duty Forces

    DTIC Science & Technology

    1993-05-14

    gangs sprouted as a direct result of the threat from the CRIPs . One of the more well known of these new gangs is the Bloods . Figure 2 - Spread Of The... CRIPs , red for BLOODs , etc. In addition gang members often associate themselves with designer athletic clothing. The gang’s colors are their uniform, much...associated violence and drugs are a real and growing threat to the security of the nation.’ One of the largest street gangs in the country is the CRIPs

  7. Analysis Extract. AFSC 4D0X1 Diet Therapy (Active Duty)

    DTIC Science & Technology

    2002-07-01

    87* 22* V0140 Diet(s) exp- Kosher Diet Active Active Active Active AD...98 % 94 % Total in group: 23* 29* 52* 41* 119* V0140 Diet(s) exp- Kosher Diet...13* 8* V0140 Diet(s) exp- Kosher Diet AETC ACC AMC AFMC PACAF USAFE

  8. Angiotensin-(1-7): an active member of the renin-angiotensin system.

    PubMed

    Kucharewicz, I; Pawlak, R; Matys, T; Chabielska, E; Buczko, W

    2002-12-01

    Angiotensin-(1-7) [Ang-(1-7)] is an active member of renin-angiotensin system (RAS). It counterbalances vasoconstriction, mitogenic, arrhythmogenic and prothrombotic actions of Ang II. Inducing natiuresis and diuresis opposes also the water and sodium retention produced by Ang II. Till now the specific receptor side for Ang-(1-7) has been not cloned, but the current data strongly suggest that an interaction (cross-talk) between angiotensin receptors may play a role in the effects of Ang-(1-7).

  9. Activating chronic kidney disease patients and family members through the Internet to promote integration of care

    PubMed Central

    Trisolini, Michael; Roussel, Amy; Zerhusen, Eileen; Schatell, Dorian; Harris, Shelly; Bandel, Karen; Salib, Philip; Klicko, Kristi

    2004-01-01

    Abstract Purpose To describe the potential role of the Internet as a vehicle for improving integration of care through activating chronic kidney disease patients and their family members. Also, to describe how that potential is being developed through a website sponsored by the Medicare program in the United States. Background The Internet is expanding at a rapid rate, and health-related websites are one of its most popular features. Efforts to promote integration of care have focused mainly on providers up to now, and more emphasis is needed on the potential roles of patients. Chronically ill patients have particular needs for improved education about their conditions and enhanced involvement in care planning and treatment decisions. Medicare developed the Dialysis Facility Compare website to serve those goals for people with chronic kidney disease. Methods We conducted qualitative research with 140 chronic kidney disease patients and family members, and 130 renal care professionals to evaluate and improve the Dialysis Facility Compare website. A series of 19 focus groups, 13 triads (small focus groups), and 56 individual interviews were conducted in four regions of the United States and by telephone. Results We found that the Dialysis Facility Compare website has the potential to improve integration of care for people with chronic kidney disease in at least three ways. First: by expanding the roles of patients as members of the multi-disciplinary team of caregivers treating their disease. Second: through better integration of the informal care provided in the home and community with the formal care provided by health professionals. Third: by improving coordination of between care provided in the pre-dialysis and dialysis phases of the disease. Discussion We developed recommendations for revising and enhancing the Dialysis Facility Compare website in a number of ways to better promote patient activation and integration of care. The unique features of the Internet

  10. Trends in the incidence of physician-diagnosed mild traumatic brain injury among active duty U.S. military personnel between 1997 and 2007.

    PubMed

    Cameron, Kenneth L; Marshall, Stephen W; Sturdivant, Rodney X; Lincoln, Andrew E

    2012-05-01

    Mild traumatic brain injury (mTBI) has been described as the most common form of traumatic brain injury within military populations; however, few epidemiologic studies have examined incidence rates for mTBI in this population. The objective of this study was to examine trends in the incidence of mTBI among active-duty U.S. service members between 1997 and 2007. Specifically, we were interested in evaluating trends in the incidence rates in relation to the initiation of combat operations in Iraq and Afghanistan. A retrospective cohort study was conducted utilizing data extracted from the Defense Medical Surveillance System to identify all incident cases of mTBI within the study population. The primary outcome of interest was the incidence rate of mTBI per 1000 person-years. Multivariable Poisson regression was used to analyze the data. There were 98,012 mTBI cases and 14,956,955 person-years of follow-up, for an overall incidence rate of 6.55 (95% CI 6.51,6.59) per 1000 person-years. There was a steady increase in the mTBI rate over time. The average change in the mTBI rate was 8.5% (95% CI 8.2%,8.8%) per year; however, the rate rose dramatically in the last 2 years of the study period. Overall, for 2006-2007 versus 1997-2005, the rate ratio was 1.61 (95% CI 1.58,1.65). The greatest increase in the rate of mTBI was observed among those serving in Iraq, who experienced a 38.4% (95% CI 35.4%,41.1%) annual increase in new cases. The observed increase in the incidence of mTBI in this population has significant policy implications in terms of allocating appropriate health care resources.

  11. Prolonged electrical stimulation-induced gluteal and hamstring muscle activation and sitting pressure in spinal cord injury: effect of duty cycle.

    PubMed

    Smit, Christof A J; Legemate, Karin J A; de Koning, Anja; de Groot, Sonja; Stolwijk-Swuste, Janneke M; Janssen, Thomas W J

    2013-01-01

    Pressure ulcers (PUs) are highly prevalent in people with spinal cord injury (SCI). Electrical stimulation (ES) activates muscles and might reduce risk factors. Our objectives were to study and compare the effects of two duty cycles during 3 h of ES-induced gluteal and hamstring activation on interface pressure distribution in sitting individuals with SCI and study the usability of a newly developed electrode garment (ES shorts). Ten individuals with SCI participated in this study, in which two ES protocols with different duty cycles (1:1 s vs 1:4 s on-off) were applied in counterbalanced order using a custom-made garment with built-in electrodes. Outcome variables included interface pressure of the ischial tuberosities (ITs) and pressure gradient. A questionnaire was used to determine usability of the ES shorts. In both protocols, ES caused a significant decrease in average IT pressure compared with rest (no ES); on average, 35% for protocol 1:4 and 13% for protocol 1:1. The ES on-off duty cycle of protocol 1:4 showed less muscle fatigue. In general, participants scored the usability of the ES shorts as satisfactory. In this study, the application of ES resulted in a significant decrease in IT pressure. The ES on-off duty cycle of 1:4 s is recommended because of the less fatiguing effect. ES of the hamstrings and gluteal muscles might be a promising method in preventing PUs, but further study is needed.

  12. Spice: a new "legal" herbal mixture abused by young active duty military personnel.

    PubMed

    Bebarta, Vikhyat S; Ramirez, Sasha; Varney, Shawn M

    2012-01-01

    Spice is an herbal mixture smoked for euphoria and mixed with synthetic cannabinoids that are undetected on urine drug screens. Spice use has increased in the military because it is considered legal and is not detected on urine drug screen. The authors describe 3 cases of Spice use in military members. Case 1: 19-year-old male presented with paranoia, agitation, and visual hallucinations after smoking the "Space" brand of Spice. Urine thin-layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) were negative. Case 2: 19-year-old female presented with sedation, amnesia, and agitation. She smoked the "Space" brand. She was alert within 3 hours of arrival. Urine GC-MS detected levorphanol. Case 3: 23-year-old male presented with delusions and paranoia. He complained of "monsters on his back." His symptoms improved in the emergency department (ED). His urine TLC and GC-MS were negative. All cases were admitted and evaluated by a toxicologist; all 3 had their history corroborated by family or friends, or with drug paraphernalia. Spice is a new herbal mixture that is increasingly used in the military. Expected effects are similar to cannabis, but may include more paranoia and hallucinations, and may differ for each brand.

  13. 14 CFR 117.5 - Fitness for duty.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Fitness for duty. 117.5 Section 117.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... REST REQUIREMENTS: FLIGHTCREW MEMBERS § 117.5 Fitness for duty. (a) Each flightcrew member must...

  14. Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

    PubMed Central

    Fielding, Ceri A; Weekes, Michael P; Nobre, Luis V; Ruckova, Eva; Wilkie, Gavin S; Paulo, Joao A; Chang, Chiwen; Suárez, Nicolás M; Davies, James A; Antrobus, Robin; Stanton, Richard J; Aicheler, Rebecca J; Nichols, Hester; Vojtesek, Borek; Trowsdale, John; Davison, Andrew J; Gygi, Steven P

    2017-01-01

    The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation. DOI: http://dx.doi.org/10.7554/eLife.22206.001 PMID:28186488

  15. B7x: A widely expressed B7 family member that inhibits T cell activation

    PubMed Central

    Zang, Xingxing; Loke, P'ng; Kim, Jayon; Murphy, Kenneth; Waitz, Rebecca; Allison, James P.

    2003-01-01

    B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4+ and CD8+ T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in downregulation of tissue-specific autoimmunity and antitumor responses. PMID:12920180

  16. Active-Duty Physicians' Perceptions and Satisfaction with Humanitarian Assistance and Disaster Relief Missions: Implications for the Field

    PubMed Central

    Oravec, Geoffrey J.; Artino, Anthony R.; Hickey, Patrick W.

    2013-01-01

    Background The United States Department of Defense participates in more than 500 missions every year, including humanitarian assistance and disaster relief, as part of medical stability operations. This study assessed perceptions of active-duty physicians regarding these activities and related these findings to the retention and overall satisfaction of healthcare professionals. Methods and Findings An Internet-based survey was developed and validated. Of the 667 physicians who responded to the survey, 47% had participated in at least one mission. On a 7-point, Likert-type response scale, physicians reported favorable overall satisfaction with their participation in these missions (mean  = 5.74). Perceived benefit was greatest for the United States (mean  = 5.56) and self (mean  = 5.39) compared to the target population (mean  = 4.82). These perceptions were related to participants' intentions to extend their military medical service (total model R2  = .37), with the strongest predictors being perceived benefit to self (β = .21, p<.01), the U.S. (β = .19, p<.01), and satisfaction (β = .18, p<.05). In addition, Air Force physicians reported higher levels of satisfaction (mean  = 6.10) than either Army (mean  = 5.27, Cohen's d = 0.75, p<.001) or Navy (mean  = 5.60, Cohen's d  = 0.46, p<.01) physicians. Conclusions Military physicians are largely satisfied with humanitarian missions, reporting the greatest benefit of such activities for themselves and the United States. Elucidation of factors that may increase the perceived benefit to the target populations is warranted. Satisfaction and perceived benefits of humanitarian missions were positively correlated with intentions to extend time in service. These findings could inform the larger humanitarian community as well as military medical practices for both recruiting and retaining medical professionals. PMID:23555564

  17. Sport for All? Insight into Stratification and Compensation Mechanisms of Sporting Activity in the 27 European Union Member States

    ERIC Educational Resources Information Center

    Van Tuyckom, Charlotte; Scheerder, Jeroen

    2010-01-01

    Physical activity is an important public health issue and the benefits of an active lifestyle in relation to well-being and health have been strongly emphasised in recent years in Europe, as well as in most parts of the world. However, previous research has shown that physical activity within Europe and its member states is stratified. The present…

  18. Stress, mental health, and job performance among active duty military personnel: findings from the 2002 Department of Defense Health-Related Behaviors Survey.

    PubMed

    Hourani, Laurel L; Williams, Thomas V; Kress, Amii M

    2006-09-01

    This study examined the extent to which high levels of occupational and family stress were associated with mental health problems and productivity loss among active duty military personnel. We analyzed data from the 2002 Department of Defense Survey of Health-Related Behaviors among Military Personnel, which provided extensive population-based information on 12,756 active duty personnel in all branches of the military worldwide. Military personnel reported higher levels of stress at work than in their family life. The personnel reporting the highest levels of occupational stress were those 25 or younger, those who were married with spouses not present, and women. Personnel with high levels of stress had significantly higher rates of mental health problems and productivity loss than those with less stress. We recommend that prevention and intervention efforts geared toward personnel reporting the highest levels of stress be given priority for resources in this population.

  19. Suicide Deaths of Active-Duty U.S. Military and Omega-3 Fatty-Acid Status: A Case-Control Comparison

    DTIC Science & Technology

    2011-01-01

    Deaths e1J Clin Psychiatry Suicide Deaths of Active-Duty US Military and Omega -3 Fatty - Acid Status: A Case-Control Comparison Michael D. Lewis, MD...factors. Objective: To determine whether deficiencies of neuroactive, highly unsaturated omega -3 essential fatty acids (n-3 HUFAs), in particular...U.S. Military And Omega -3 Fatty - Acid Status: A Case-Control Comparison 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR

  20. The Effect of Deployment on the Rate of Major Depression and Substance Abuse in Active Duty Military from 2001-2006

    DTIC Science & Technology

    2011-03-01

    Major Depression , Rates of Substance Abuse, Deployment Effects, OEF, OIF, Comorbidity, Mental Health Illness 16. PRICE CODE 17. SECURITY...health illness . This thesis evaluates the effects of deployment history on major depression and substance abuse in the active duty population from...trend in mental health illness , depression , and substance abuse being the top two diagnoses. Mental health illness affects readiness, and the cost of

  1. Signal Transducers and Activators of Transcription (STAT) Family Members in Helminth Infections

    PubMed Central

    Becerra-Díaz, Mireya; Valderrama-Carvajal, Héctor; Terrazas, Luis I.

    2011-01-01

    Helminth parasites are a diverse group of multicellular organisms. Despite their heterogeneity, helminths share many common characteristics, such as the modulation of the immune system of their hosts towards a permissive state that favors their development. They induce strong Th2-like responses with high levels of IL-4, IL-5 and IL-13 cytokines, and decreased production of proinflammatory cytokines such as IFN-γ. IL-4, IFN-γ and other cytokines bind with their specific cytokine receptors to trigger an immediate signaling pathway in which different tyrosine kinases (e.g. Janus kinases) are involved. Furthermore, a seven-member family of transcription factors named Signal Transducers and Activators of Transcription (STAT) that initiate the transcriptional activation of different genes are also involved and regulate downstream the JAK/STAT signaling pathway. However, how helminths avoid and modulate immune responses remains unclear; moreover, information concerning STAT-mediated immune regulation during helminth infections is scarce. Here, we review the research on mice deficient in STAT molecules, highlighting the importance of the JAK/STAT signaling pathway in regulating susceptibility and/or resistance in these infections. PMID:22110388

  2. NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia.

    PubMed

    Gao, Q; Lu, J; Huo, Y; Baby, N; Ling, E A; Dheen, S T

    2010-01-20

    Activation of microglial cells, the resident immune cells of the CNS causes neurotoxicity through the release of a wide array of inflammatory mediators including proinflammatory cytokines, chemokines and reactive oxygen species. In this study, we have investigated the expression of NG2 (also known as CSPG4), one of the members of transmembrane chondroitin sulfate proteoglycans family, in microglial cells and its role on inflammatory reaction of microglia by analyzing the expression of the proinflammation cytokines (interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha)), chemokines (stromal cell-derived factor-1alpha and monocyte chemotactic protein-1) and inducible nitric oxide synthase (iNOS). NG2 expression was not detectable in microglial cells expressing OX-42 in the brains of 1-day old postnatal rat pups and adult rats; it was, however, induced in activated microglial cells in pups and adult rats injected with lipopolysaccharide (LPS). In vitro analysis further confirmed that LPS induced the expression of NG2 in primary microglial cells and this was inhibited by dexamethasone. It has been well demonstrated that LPS induces the expression of iNOS and proinflammatory cytokines in microglia. However in this study, LPS did not induce the mRNA expression of iNOS and cytokines including IL-1beta, and TNF-alpha in microglial cells transfected with CSPG4 siRNA. On the contrary, mRNA expression of chemokines such as monocyte chemoattractant protein-1 (MCP-1) and stromal cell-derived factor-1alpha (SDF-1alpha) was significantly increased in LPS-activated microglial cells after CSPG4 siRNA transfection in comparison with the control. The above results indicate that NG2 mediates the induction of iNOS and inflammatory cytokine expression, but not the chemokine expression in activated microglia.

  3. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... AmeriCorps members perform should enhance the mission, strategy, skills, and culture, as well as systems...) Developing organizational systems to improve efficiency and effectiveness; (iv) Automating...

  4. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... AmeriCorps members perform should enhance the mission, strategy, skills, and culture, as well as systems...) Developing organizational systems to improve efficiency and effectiveness; (iv) Automating...

  5. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... AmeriCorps members perform should enhance the mission, strategy, skills, and culture, as well as systems...) Developing organizational systems to improve efficiency and effectiveness; (iv) Automating...

  6. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AmeriCorps members perform should enhance the mission, strategy, skills, and culture, as well as systems...) Developing organizational systems to improve efficiency and effectiveness; (iv) Automating...

  7. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AmeriCorps members perform should enhance the mission, strategy, skills, and culture, as well as systems...) Developing organizational systems to improve efficiency and effectiveness; (iv) Automating...

  8. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  9. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  10. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  11. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  12. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  13. Organizational Member Involvement in Physical Activity Coalitions across the United States: Development and Testing of a Novel Survey Instrument for Assessing Coalition Functioning

    ERIC Educational Resources Information Center

    Bornstein, Daniel B.; Pate, Russell R.; Beets, Michael W.; Saunders, Ruth P.; Blair, Steven N.

    2015-01-01

    Introduction: Coalitions are often composed of member organizations. Member involvement is thought to be associated with coalition success. No instrument currently exists for evaluating organizational member involvement in physical activity coalitions. This study aimed to develop a survey instrument for evaluating organizational member involvement…

  14. What Are the Affectionate Reactions of Students to Activities by Faculty Members during Courses?

    ERIC Educational Resources Information Center

    Alacapinar, Fusun Gulderen

    2016-01-01

    Problem Statement: Faculty members working in the education faculties of universities are expected to show teacher behaviors. In articles on this subject, some research on teacher behavior can be found. Some articles on this subject exist in the literature in foreign countries. These studies show that faculty members teaching in universities do…

  15. Very low arylsulfatase A and cerebroside sulfatase activities in leukocytes of healthy members of metachromatic leukodystrophy family.

    PubMed Central

    Dubois, G; Harzer, K; Baumann, N

    1977-01-01

    Very low levels of arylsulfatase A (ASA) have been found in the leukocytes of healthy members of a metachromatic leukodystrophy (MLD) family. The cerebroside sulfate sulfatase (CSS) activities in the same individuals are about 10% of the control level. Arguments favoring a dominant mutation different from that of classical MLD are presented. This report reinforces the relationship between the two enzymatic activities. PMID:15452

  16. 24 CFR 960.204 - Denial of admission for criminal activity or drug abuse by household members.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Denial of admission for criminal... HOUSING Admission § 960.204 Denial of admission for criminal activity or drug abuse by household members. (a) Required denial of admission—(1) Persons evicted for drug-related criminal activity. The...

  17. 78 FR 70533 - Certain Activated Carbon From the People's Republic of China: Final Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ...] [FR Doc No: 2013-28359] DEPARTMENT OF COMMERCE International Trade Administration [A-570-904] Certain... Fourth Antidumping Duty Administrative Review; 2011-2012, 78 FR 26748 (May 8, 2013) (``Preliminary...., 78 FR at 26749. \\4\\ See Memorandum to Christian Marsh, Deputy Assistant Secretary, Antidumping...

  18. 77 FR 30508 - Open Meeting To Obtain Input for 2013 DoD 10 Key State Issues Impacting Service Members and Their...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... improve school transition for children in active duty military families to overcome problems with records... Members and Their Families AGENCY: Department of Defense. ACTION: Notice. SUMMARY: The public is invited to attend an open session to consider issues impacting Service members and their families that...

  19. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 15 2014-04-01 2014-04-01 false Remuneration of members of the Armed Forces of... members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. Remuneration paid for active service as a member of the Armed Forces...

  20. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Remuneration of members of the Armed Forces of... members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. Remuneration paid for active service as a member of the Armed Forces...

  1. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 15 2013-04-01 2013-04-01 false Remuneration of members of the Armed Forces of... members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. Remuneration paid for active service as a member of the Armed Forces...

  2. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Remuneration of members of the Armed Forces of... members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. Remuneration paid for active service as a member of the Armed Forces...

  3. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 15 2012-04-01 2012-04-01 false Remuneration of members of the Armed Forces of... members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. Remuneration paid for active service as a member of the Armed Forces...

  4. The Effect of Reserve Activations and Active-Duty Deployments on Local Employment During the Global War on Terrorism

    DTIC Science & Technology

    2006-01-01

    by the Stata procedure, xtregar. - 25 - 4. ECONOMETRIC RESULTS In this section, we present the results of estimating the econometric model of...Department of Defense federally funded research and development centers. - iii - PREFACE This report presents an econometric analysis of the impact of...Personnel Activated and Deployed...........19 Econometric Methods.............................................20 Sample Selection

  5. 45 CFR 2550.90 - Are there any restrictions on the activities of the members of State Commissions or Alternative...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Are there any restrictions on the activities of the members of State Commissions or Alternative Administrative Entities? 2550.90 Section 2550.90 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND...

  6. 45 CFR 2550.90 - Are there any restrictions on the activities of the members of State Commissions or Alternative...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Are there any restrictions on the activities of the members of State Commissions or Alternative Administrative Entities? 2550.90 Section 2550.90 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND...

  7. 45 CFR 2550.90 - Are there any restrictions on the activities of the members of State Commissions or Alternative...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Are there any restrictions on the activities of the members of State Commissions or Alternative Administrative Entities? 2550.90 Section 2550.90 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND...

  8. A Beach and Dune Community. 4-H Marine Science. Member's Guide. Activity I. MSp 1.

    ERIC Educational Resources Information Center

    Auburn Univ., AL. Cooperative Extension Service.

    The investigation in this booklet is designed to provide 4-H members with opportunities to identify common plants and animals found on beaches and sand dunes and to determine the role of the plants and animals in this community. Learners are provided with a picture of a hypothetical beach and sand dune and a list of organisms (included in the…

  9. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

    PubMed

    Perdomo, J; Holmes, M; Chong, B; Crossley, M

    2000-12-08

    Members of the Ikaros family of transcription factors, Ikaros, Aiolos, and Helios, are expressed in lymphocytes and have been implicated in controlling lymphoid development. These proteins contain two characteristic clusters of zinc fingers, an N-terminal domain important for DNA recognition, and a C-terminal domain that mediates homo- and heterotypic associations between family members. The conservation of these domains is such that all three proteins recognize related DNA sequences, and all are capable of dimerizing with other family members. Here we describe two additional Ikaros family proteins, Eos and Pegasus. Eos is most highly related to Helios and shares its DNA binding and protein association properties. Pegasus is related to other Ikaros proteins in its C-terminal dimerization domain but contains a divergent N-terminal zinc finger domain. Pegasus self-associates and binds to other family members but recognizes distinct DNA-binding sites. Eos and Pegasus repress the expression of reporter genes containing their recognition elements. Our results suggest that these proteins may associate with previously described Ikaros family proteins in lymphoid cells and play additional roles in other tissues.

  10. 14 CFR 117.5 - Fitness for duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Fitness for duty. 117.5 Section 117.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... REST REQUIREMENTS: FLIGHTCREW MEMBERS (EFF. 1-4-14) § 117.5 Fitness for duty. (a) Each...

  11. Union Members Are Community Members

    ERIC Educational Resources Information Center

    Gray, David

    2013-01-01

    Unions serve their members' interests. But union members are also community members, and their interests go well beyond increasing pay and benefits. A local union president has found that his members are best served by participating in a community-wide coalition. Providing eyeglasses to needy students, promoting healthy eating, and increasing…

  12. New seven membered palladacycles: C-Br bond activation of 2-bromo-pyridine derivative by Pd(II).

    PubMed

    Nicasio-Collazo, Juan; Álvarez, Eleuterio; Alvarado-Monzón, José C; Andreu-de-Riquer, Gabriel; Jimenez-Halla, J Oscar C; De León-Rodríguez, Luis M; Merino, Gabriel; Morales, Ubaldo; Serrano, Oracio; López, Jorge A

    2011-12-14

    C-Br bond activation followed by a C-C coupling reaction of the 2-bromo-pyridyl unit of [1-phenyl-2-(6-bromopyridin-2-yl)-benzoimidazole] was performed by Pd(CH(2)CMe(2)-o-C(6)H(4))(η(4)-COD). Two new seven membered palladacycles were obtained. A combined experimental and theoretical DFT study elucidates the mechanism for this reaction.

  13. The Willingness of Military Members to Seek Help: The Role of Social Involvement and Social Responsibility.

    PubMed

    Bowen, Gary L; Jensen, Todd M; Martin, James A; Mancini, Jay A

    2016-03-01

    Anchored in the social organization theory of action and change, we use data from a large sample of active-duty Air Force members to examine the direct and indirect influence of social involvement and social responsibility on willingness to seek help in times of need via trust in formal systems and informal supports. Group comparisons are conducted between junior male, junior female, senior male, and senior female service members. The key mediational path in the model for all groups is the connection between social involvement and willingness to seek help via trust in formal systems. These results can inform both unit- and community-level interventions intended to increase the likelihood that active-duty AF members will seek help in times of need.

  14. Characteristics of particle number and mass emissions during heavy-duty diesel truck parked active DPF regeneration in an ambient air dilution tunnel

    NASA Astrophysics Data System (ADS)

    Yoon, Seungju; Quiros, David C.; Dwyer, Harry A.; Collins, John F.; Burnitzki, Mark; Chernich, Donald; Herner, Jorn D.

    2015-12-01

    Diesel particle number and mass emissions were measured during parked active regeneration of diesel particulate filters (DPF) in two heavy-duty diesel trucks: one equipped with a DPF and one equipped with a DPF + SCR (selective catalytic reduction), and compliant with the 2007 and 2010 emission standards, respectively. The emission measurements were conducted using an ambient air dilution tunnel. During parked active regeneration, particulate matter (PM) mass emissions measured from a 2007 technology truck were significantly higher than the emissions from a 2010 technology truck. Particle number emissions from both trucks were dominated by nucleation mode particles having a diameter less than 50 nm; nucleation mode particles were orders of magnitude higher than accumulation mode particles having a diameter greater than 50 nm. Accumulation mode particles contributed 77.8 %-95.8 % of the 2007 truck PM mass, but only 7.3 %-28.2 % of the 2010 truck PM mass.

  15. Entamoeba histolytica: a unicellular organism containing two active genes encoding for members of the TBP family.

    PubMed

    Castañon-Sanchez, Carlos Alberto; Luna-Arias, Juan Pedro; de Dios-Bravo, Ma Guadalupe; Herrera-Aguirre, Maria Esther; Olivares-Trejo, Jose J; Orozco, Esther; Hernandez, Jose Manuel

    2010-03-01

    Entamoeba histolytica is the protozoan parasite which causes human amoebiasis. In this parasite, few encoding genes for transcription factors have been cloned and characterized. The E. histolytica TATA-box binding protein (EhTBP) is the first basal transcription factor that has been studied. To continue with the identification of other members of the basal transcription machinery, we performed an in silico analysis of the E. histolytica genome and found three loci encoding for polypeptides with similarity to EhTBP. One locus has a 100% identity to the previously Ehtbp gene reported by our group. The second locus encodes for a 212 aa polypeptide that is 100% identical to residues 23-234 from EhTBP. The third one encodes for a 216 aa polypeptide of 24kDa that showed 42.6% identity and 73.7% similarity to EhTBP. This protein was named E. histolytica TBP-related factor 1 (EhTRF1). Ehtrf1 gene was expressed in bacteria and the purified 28kDa recombinant polypeptide showed the capacity to bind to TATTTAAA-box by electrophoretic mobility shift assays. K(D) values for rEhTBP and rEhTRF1 were (1.71+/-2.90)x10(-12)M and (1.12+/-0.160)x10(-11)M, respectively. Homology modeling of EhTRF1 and EhTBP revealed that, although they were very similar, they showed some differences on their surfaces. Thus, E. histolytica is a unicellular organism having two members of the TBP family.

  16. 7 CFR 916.27 - Alternate members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... member and perform such other duties as assigned. In the event of the death, removal, resignation, or... qualified. In the event both a member of the committee and his alternate are unable to attend a...

  17. The Role of Natural Support Systems in the Post-deployment Adjustment of Active Duty Military Personnel.

    PubMed

    Welsh, Janet A; Olson, Jonathan; Perkins, Daniel F; Travis, Wendy J; Ormsby, LaJuana

    2015-09-01

    This study examined the relations among three different types of naturally occurring social support (from romantic partners, friends and neighbors, and unit leaders) and three indices of service member well-being (self reports of depressive symptoms, satisfaction with military life, and perceptions of unit readiness) for service members who did and did not report negative experiences associated with military deployment. Data were drawn from the 2011 Community Assessment completed anonymously by more than 63,000 USAF personnel. Regression analyses revealed that higher levels of social support was associated with better outcomes regardless of negative deployment experiences. Evidence of moderation was also noted, with all forms of social support moderating the impact of negative deployment experiences on depressive symptoms and support from unit leaders moderating the impact of negative deployment experience on satisfaction with military life. No moderation was found for perceptions of unit readiness. Subgroup analyses revealed slightly different patterns for male and female service members, with support providing fewer moderation effects for women. These findings may have value for military leaders and mental health professionals working to harness the power of naturally occurring relationships to maximize the positive adjustment of service members and their families. Implications for practices related to re-integration of post-deployment military personnel are discussed.

  18. Cosmetology Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for three occupations in the cosmetology series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide…

  19. Microcomputer Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for eight occupations in the microcomputer series. Each occupation is divided into 5 to 11 duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide space…

  20. Printing Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for 10 occupations in the printing series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide space for…

  1. Welding Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for six occupations in the welding series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide space for…

  2. Plants contain a novel multi-member class of heat shock factors without transcriptional activator potential.

    PubMed

    Czarnecka-Verner, E; Yuan, C X; Scharf, K D; Englich, G; Gurley, W B

    2000-07-01

    Based on phylogeny of DNA-binding domains and the organization of hydrophobic repeats, two families of heat shock transcription factors (HSFs) exist in plants. Class A HSFs are involved in the activation of the heat shock response, but the role of class B HSFs is not clear. When transcriptional activities of full-length HSFs were monitored in tobacco protoplasts, no class B HSFs from soybean or Arabidopsis showed activity under control or heat stress conditions. Additional assays confirmed the finding that the class B HSFs lacked the capacity to activate transcription. Fusion of a heterologous activation domain from human HSF1 (AD2) to the C-terminus of GmHSFB1-34 gave no evidence of synergistic enhancement of AD2 activity, which would be expected if weak activation domains were present. Furthermore, activity of AtHSFB1-4 (class B) was not rescued by coexpression with AtHSFA4-21 (class A) indicating that the class A HSF was not able to provide a missing function required for class B activity. The transcriptional activation potential of Arabidopsis AtHSFA4-21 was mapped primarily to a 39 amino acid fragment in the C-terminus enriched in bulky hydrophobic and acidic residues. Deletion mutagenesis of the C-terminal activator regions of tomato and Arabidopsis HSFs indicated that these plant HSFs lack heat-inducible regulatory regions analogous to those of mammalian HSF1. These findings suggest that heat shock regulation in plants may differ from metazoans by partitioning negative and positive functional domains onto separate HSF proteins. Class A HSFs are primarily responsible for stress-inducible activation of heat shock genes whereas some of the inert class B HSFs may be specialized for repression, or down-regulation, of the heat shock response.

  3. A new L5 brown dwarf member of the Hyades cluster with chromospheric activity

    NASA Astrophysics Data System (ADS)

    Pérez-Garrido, A.; Lodieu, N.; Rebolo, R.

    2017-03-01

    Aims: Our aim is to identify brown dwarf members of the nearby Hyades open star cluster to determine the photometric and spectroscopic properties of brown dwarfs at moderately old ages and extend the knowledge of the substellar mass function of the cluster. Methods: We cross-matched the 2MASS and AllWISE public catalogues and measured proper motions to identify low-mass stars and brown dwarf candidates in an area of radius eight degrees around the central region of the Hyades cluster. We identified objects with photometry and proper motions consistent with cluster membership. For the faintest (J = 17.2 mag) most promising astrometric and photometric low-mass candidate 2MASS J04183483+2131275, with a membership probability of 94.5%, we obtained low-resolution (R = 300-1000) and intermediate-resolution (R = 2500) spectroscopy with the 10.4m Gran Telescopio Canarias. Results: From the low-resolution spectra we determined a L5.0 ± 0.5 spectral type, consistent with the available photometry. In the intermediate dispersion spectrum we detected Hα in emission (marginally resolved with a full width half maximum of 2.8 Å) and determined a log (LHα/Lbol) = -6.0 dex. From Hα we obtained a radial velocity of 38.0 ± 2.9 km s-1, which combined with the proper motion leads to space velocities which are fully consistent with membership in the Hyades cluster. We also report a detection in the H2 band by the UKIDSS Galactic Plane Survey. Using evolutionary models we determine from the available photometry of the object a mass in the range 0.039-0.055 M⊙. Brown dwarfs with masses below 0.055 M⊙ should fully preserve its initial lithium content, and indeed the spectrum at 6708 Å may show a feature consistent with lithium preservation; however, a higher S/N is needed to confirm this point. Conclusions: We have identified a new high-probability L5 brown dwarf member of the Hyades cluster. This is the first relatively old L5 brown dwarf with a well-determined age (500-700 Myr

  4. Group Member or Outsider: Perceptions of Undergraduates with Disabilities on Leisure Time Physical Activity

    ERIC Educational Resources Information Center

    Devine, Mary Ann

    2013-01-01

    College provides students with many opportunities to achieve academic success and enrich other aspects of their lives. Participating in campus activities can reduce stress, create social connections, promote healthy active living, and broaden civic engagement (Lindsey & Sessoms, 2006; Watson, Ayers, Zizzi, & Naoi, 2006). Studies noting…

  5. Stable Isotope Probing: Linking Functional Activity to Specific Members of Microbial Communities

    SciTech Connect

    Kreuzer-Martin, Helen W.

    2007-03-12

    Abstract Linking organisms or groups of organisms to specific functions within natural environments is a fundamental challenge in microbial ecology. Advances in technology for manipulating and analyzing nucleic acids have made it possible to characterize the members of microbial communities without the intervention of laboratory culturing. Results from such studies have shown that the vast majority of soil organisms have never been cultured, highlighting the risks of culture-based approaches in community analysis. The development of culture-independent techniques for following the flow of substrates through microbial communities therefore represents an important advance. These techniques, collectively known as stable isotope probing (SIP), involve introducing a stable isotope-labeled substrate into a microbial community and following the fate of the substrate by detecting the appearance of the isotope in diagnostic molecules such as fatty acids and nucleic acids. The molecules in which the isotope label appears provide identifying information about the organism that incorporated the substrate. SIP allows direct observations of substrate assimilation in minimally disturbed communities, and thus represents an exciting new tool for linking microbial identity and function. The use of lipids or nucleic acids as the diagnostic molecule brings different strengths and weaknesses to the experimental approach, and necessitates the use of significantly different instrumentation and analytical techniques. This mini-review provides an overview of the lipid and nucleic acid approaches, discusses their strengths and weaknesses, gives examples of applications in various settings, and looks at prospects for the future of SIP technology.

  6. Successful Nonoperative Management of HAGL (Humeral Avulsion of Glenohumeral Ligament) Lesion With Concurrent Axillary Nerve Injury in an Active-Duty US Navy SEAL.

    PubMed

    Ernat, Justin J; Bottoni, Craig R; Rowles, Douglas J

    2016-01-01

    Humeral avulsion of the glenohumeral ligament (HAGL) is a lesion that has been recognized as a cause of recurrent shoulder instability. To our knowledge there are no reports of successful return to full function in young, competitive athletes or return to manual labor following nonoperative management of a HAGL lesion. A 26-year-old Navy SEAL was diagnosed with a HAGL injury, and associated traction injury of the axillary nerve as well as a partial tear of the rotator cuff. Operative intervention was recommended; however, due to issues with training and with inability to properly rehab with the axillary nerve injury, surgical plans were delayed. Interestingly, the patient demonstrated both clinical and radiographic magnetic resonance imaging healing of his lesion over an 18-month period. At 18 months the patient had returned to full active duty without pain or instability as a Navy SEAL.

  7. Antimicrobial activity of fatty acid methyl esters of some members of Chenopodiaceae.

    PubMed

    Chandrasekaran, Manivachagam; Kannathasan, Krishnan; Venkatesalu, Venugopalan

    2008-01-01

    Fatty acid methyl ester (FAME) extracts of four halophytic plants, viz. Arthrocnemum indicum, Salicornia brachiata, Suaeda maritima and Suaeda monoica belonging to the family Chenopodiaceae, were prepared and their composition was analyzed by GC-MS. The FAME extracts were also screened for antibacterial and antifungal activities. The GC-MS analysis revealed the presence of more saturated fatty acids than unsaturated fatty acids. Among the fatty acids analyzed, the relative percentage of lauric acid was high in S. brachiata (61.85%). The FAME extract of S. brachiata showed the highest antibacterial and antifungal activities among the extracts tested. The other three extracts showed potent antibacterial and moderate anticandidal activities.

  8. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... activities that provide a direct, measurable benefit to an individual, a group, or a community. (d) Examples... to, the following: (1) Tutoring children in reading; (2) Helping to run an after-school program;...

  9. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... activities that provide a direct, measurable benefit to an individual, a group, or a community. (d) Examples... to, the following: (1) Tutoring children in reading; (2) Helping to run an after-school program;...

  10. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... activities that provide a direct, measurable benefit to an individual, a group, or a community. (d) Examples... to, the following: (1) Tutoring children in reading; (2) Helping to run an after-school program;...

  11. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... activities that provide a direct, measurable benefit to an individual, a group, or a community. (d) Examples... to, the following: (1) Tutoring children in reading; (2) Helping to run an after-school program;...

  12. Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes.

    PubMed

    Gu, Keli; Bi, Lanrong; Zhao, Ming; Wang, Chao; Dolan, Cheryl; Kao, Michael C; Tok, Jeffrey B-H; Peng, Shiqi

    2006-03-01

    A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes, and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships.

  13. Weight Loss Behaviors Used by Active Duty Air Force Personnel to Maintain Compliance with Weight Control Standards

    DTIC Science & Technology

    1997-05-01

    standards (AFI 40-502,1994). 90-Day Exercise Program A specifically designed conditioning and dietary program for members in the WMP (AFI 40-502, 1994...billion is spent annually in America for these programs. They did note that dietary changes were the most common weight loss strategy. This covers...method by body builders. Competitive swimmers have been studied to determine their perception of weight and how they control their weight (Dummer

  14. To amend the Internal Revenue Code of 1986 to extend for one year the employer wage credit for employees who are active duty members of the uniformed services.

    THOMAS, 113th Congress

    Rep. Grayson, Alan [D-FL-9

    2014-01-28

    01/28/2014 Referred to the House Committee on Ways and Means. (All Actions) Notes: For further action, see H.R.5771, which became Public Law 113-295 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  15. A Study to Identify Those Variables Which Contribute to the Utilization of Wellness Clinic Services by Active Duty Army Family Members

    DTIC Science & Technology

    1985-07-01

    Teresa. Idem. 23. Cooper, Phillip D., Kehoe, William J. and Murphy, Patrick E . Marketing and Preventive Health Care: Interdisciplinary and...Hospitals. August, 1981 pp. 23-25. 25. Cooper, p. 20. 26. MacStravic, Robin E . Marketing Health Care. Aspen Systems, 1977, p. 157. 27. Fleming...Hospitals. August, 1981 pp. 23-25. Cooper, Phillip D., Kehoe, William J. and Murphy, Patrick E . Marketing and Preventive Health Care: Interdisciplinary

  16. The Potential Effects of the Defense Business Board Military Compensation Task Group’s 2011 Recommendations on Active-Duty Service Member Retirement

    DTIC Science & Technology

    2012-12-01

    Plan 5 The military did not begin participating in the TSP until 2001. Although this is the case , the TSP has been in existence since 1986 when...Human Resource Strategy did not recommend cuts in military compensation due to the unfairness of the MRRA. Taking the lead from the DSB, Congress...per year (Henning, 2011). The task group drew three main conclusions from their study. First, the system is unfair because, due to the 20-year

  17. An Analysis of Alternatives for Reducing Outpatient Military Health Care Costs for Active Duty Members and their Families: Implementing a Recommended Savings Strategy Using Defense Acquisition Principles

    DTIC Science & Technology

    2007-12-01

    now a powerful dose of Tylenol or Aleve may quickly relieve his/her symptoms. Naturally, this is the fastest and least expensive method of...drugs do not require a provider’s prescription and are also available through the internet. Some of the more common drugs are Tylenol , Aleve, and Advil...Uncommon Drugstore. Accessed in July 2007. http://www.drugstore.com. Products Symptoms Price Children’s Tylenol Common Flu $ 9.49 Tylenol Cold

  18. The Impact of Environment and Occupation on the Health and Safety of Active Duty Air Force Members - Database Development and De-Identification

    DTIC Science & Technology

    2015-04-01

    career fields, with identification of high-risk career fields for targeted interventions. Additionally, low-risk career fields could be identified for...have the potential to provide beneficial aspects including social support or camaraderie within the organization or career field. The focus of Phase...work, such as descriptive analyses, commenced. From the analyses planned in Phase II, we can identify high-risk career fields for targeted

  19. Department of Defense Sexually Transmitted Infections: Estimation of Burden among Active Duty Service Members using Clinical Diagnoses, Laboratory Results, and Medical Event Reports

    DTIC Science & Technology

    2016-03-01

    Gender Characteristics by Data Source of Patients Diagnosed with at Least One Chlamydia Infection in CY2006...10 Table 8. Service and Gender Characteristics by Data Source of Patients Diagnosed with at Least One...Gonorrhea Infection in CY2006 ...................................................................................11 Table 9. Service and Gender

  20. The Zero Suicide Program (ZSP) as a Strategy for Reduction and Prevention of Suicides Among Active Duty United States Air Force Members: A Program and Evaluation Plan

    DTIC Science & Technology

    2014-08-01

    traits, to those with “normal” stress may drastically reduce suicide rates. The ecological roles of individual, family, workplace and community stressors... stress disorder (PTSD), and only 3 met the final criteria for USAF suicide prevention. The second paper published in 2010 was a follow up to the first...are the same. Risk factors for AF suicides include failed personal relationships, marital or intimate partner strain/ stress , social isolation

  1. Effectiveness and Patient Acceptability of Stellate Ganglion Block (SGB) for Treatment of Posttraumatic Stress Disorder (PTSD) Symptoms Among Active Duty Military Members

    DTIC Science & Technology

    2016-03-01

    Page 1 of 63 AWARD NUMBER: W81XWH-15-2-0015 TITLE: Effectiveness and Patient Acceptability of Stellate Ganglion Block (SGB) for Treatment of...SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-15-2-0015 Effectiveness and Patient Acceptability of Stellate Ganglion Block (SGB) for Treatment...study seeks to evaluate the effectiveness and acceptability of stellate ganglion block (SGB) for treatment of Posttraumatic Stress Disorder (PTSD

  2. Neck and shoulder muscle activity and posture among helicopter pilots and crew-members during military helicopter flight.

    PubMed

    Murray, Mike; Lange, Britt; Chreiteh, Shadi Samir; Olsen, Henrik Baare; Nørnberg, Bo Riebeling; Boyle, Eleanor; Søgaard, Karen; Sjøgaard, Gisela

    2016-04-01

    Neck pain among helicopter pilots and crew-members is common. This study quantified the physical workload on neck and shoulder muscles using electromyography (EMG) measures during helicopter flight. Nine standardized sorties were performed, encompassing: cruising from location A to location B (AB) and performing search and rescue (SAR). SAR was performed with Night Vision Goggles (NVG), while AB was performed with (AB+NVG) and without NVG (AB-NVG). EMG was recorded for: trapezius (TRA), upper neck extensors (UNE), and sternocleido-mastoid (SCM). Maximal voluntary contractions (MVC) were performed for normalization of EMG (MVE). Neck posture of pilots and crew-members was monitored and pain intensity of neck, shoulder, and back was recorded. Mean muscle activity for UNE was ∼10% MVE and significantly higher than TRA and SCM, and SCM was significantly lower than TRA. There was no significant difference between AB-NVG and AB+NVG. Muscle activity in the UNE was significantly higher during SAR+NVG than AB-NVG. Sortie time (%) with non-neutral neck posture for SAR+NVG and AB-NVG was: 80.4%, 74.5% (flexed), 55.5%, 47.9% (rotated), 4.5%, 3.7% (lateral flexed). Neck pain intensity increased significantly from pre- (0.7±1.3) to post-sortie (1.6±1.9) for pilots (p=0.028). If sustained, UNE activity of ∼10% MVE is high, and implies a risk for neck disorders.

  3. DEVELOPMENT WORK FOR IMPROVED HEAVY-DUTY VEHICLE MODELING CAPABILITY DATA MINING--FHWA DATASETS

    EPA Science Inventory

    A heavy-duty vehicle can produce 10 to 100 times the emissions (of NOx and PM emissions especially) of a light-duty vehicle, so heavy-duty vehicle activity needs to be well characterized. Key uncertainties with the use of MOBILE6 regarding heavy-duty vehicle emissions include th...

  4. Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members.

    PubMed

    Schneider, Pascal; Willen, Laure; Smulski, Cristian R

    2014-01-01

    Ligands and receptors of the TNF superfamily are therapeutically relevant targets in a wide range of human diseases. This chapter describes assays based on ELISA, immunoprecipitation, FACS, and reporter cell lines to monitor interactions of tagged receptors and ligands in both soluble and membrane-bound forms using unified detection techniques. A reporter cell assay that is sensitive to ligand oligomerization can identify ligands with high probability of being active on endogenous receptors. Several assays are also suitable to measure the activity of agonist or antagonist antibodies, or to detect interactions with proteoglycans. Finally, self-interaction of membrane-bound receptors can be evidenced using a FRET-based assay. This panel of methods provides a large degree of flexibility to address questions related to the specificity, activation, or inhibition of TNF-TNF receptor interactions in independent assay systems, but does not substitute for further tests in physiologically relevant conditions.

  5. Early Childhood Teachers' and Staff Members' Perceptions of Nutrition and Physical Activity Practices for Preschoolers

    ERIC Educational Resources Information Center

    Derscheid, Linda E.; Umoren, Josephine; Kim, So-Yeun; Henry, Beverly W.; Zittel, Lauriece L.

    2010-01-01

    Child care teachers and staff are important influences on preschoolers' nutrition and physical activity habits, and their views may be influenced by education level, years of field experience, and program involvement. For the 360 participants surveyed, responses on 5 of 18 survey items significantly differed by education level (e.g., less…

  6. 1999 Survey of Active Duty Personnel: Administration, Datasets, and Codebook. Appendix G: Frequency and Percentage Distributions for Variables in the Survey Analysis Files.

    DTIC Science & Technology

    2000-12-01

    characteristics of your current residence and community at your permanent duty station? M9909B - Quality and condition of residence OS DATA...the following characteristics of your current residence and community at your permanent duty station? M9909E - Quality of housing in the area... Eldercare [See also M9914SK.] OS DATA _ SAS DATA _ | COLS |LENGTH| | FORMAT NAME

  7. A new tropical active serpentinization end-member discovered in Costa Rica

    NASA Astrophysics Data System (ADS)

    Sanchez-Murillo, R.; Gazel, E.; Boll, J.; Schwarzenbach, E. M.

    2013-12-01

    Serpentinization is a planetary process where ultramafic rocks react with fluids with important consequences on global biogeochemical cycles through formation of H2 and CH4. Exposed sections of upper-mantle rocks on continents, where meteoric water interacts with the ultramafic rocks, provide natural laboratories to study present-day serpentinization. Here, we present geochemical evidence of active serpentinization and methane vents in the Santa Elena Ophiolite (comprising 250 km2 of ultramafic rocks) in Costa Rica. The system is sustained by peridotites with a 50% degree of serpentinization. Two alkaline spring systems were discovered. The alkaline fluids pH ranged from 11.01 to 11.18. Mean hydroxide and carbonate concentrations were 52 mg/L and 38 mg/L. Mean dissolved calcium was 104 mg/L with a maximum of 167 mg/L. These springs are also characterized by low Mg (< 1 mg/L) and K (2.35 mg/L) and relatively high Na (21.4 mg/L) and chloride (27.1 mg/L) concentrations. Average spring temperature was 29.1°C. Active CH4 vents (24.3% volume) coupled with extensive carbonate deposits (magnesite and calcite with isotopic compositions within the range of similar ultramafic hosted systems) also provide strong evidence of active serpentinization. Groundwater and alkaline spring's hydrological connectivity was explored using stable isotope as natural tracers. Isotope composition of the alkaline fluids (d18O = -7.9‰, d2H = -51.4‰) was remarkably similar to the groundwater signature from 10 deep wells (30-70 m) (d18O = -7.6‰; dD = -48.0‰) sampled in local watersheds. These results support the hypothesis that during prolonged dry periods these alkaline springs are fed by deep subsurface storage. Mean electrical conductivity of the alkaline fluids (622 uS/cm) was considerably higher than of surface waters (470 uS/cm); this significant difference may be additional evidence of active serpentinization in the area. Overall, Santa Elena's varying weather conditions between

  8. "We Are in This Together": Common Group Identity Predicts Majority Members' Active Acculturation Efforts to Integrate Immigrants.

    PubMed

    Kunst, Jonas R; Thomsen, Lotte; Sam, David L; Berry, John W

    2015-10-01

    Although integration involves a process of mutual accommodation, the role of majority groups is often downplayed to passive tolerance, leaving immigrants with the sole responsibility for active integration. However, we show that common group identity can actively involve majority members in this process across five studies. Study 1 showed that common identity positively predicted support of integration efforts; Studies 2 and 3 extended these findings, showing that it also predicted real behavior such as monetary donations and volunteering. A decrease in modern racism mediated the relations across these studies, and Studies 4 and 5 further demonstrated that it indeed mediated these effects over and above acculturation expectations and color-blindness, which somewhat compromised integration efforts. Moreover, the last two studies also demonstrated that common, but not dual, groups motivated integration efforts. Common identity appears crucial for securing majorities' altruistic efforts to integrate immigrants and, thus, for achieving functional multiculturalism.

  9. Taonella mepensis gen. nov., sp. nov., a member of the family Rhodospirillaceae isolated from activated sludge.

    PubMed

    Xi, Xue-dong; Dong, Wei-liang; Zhang, Jun; Huang, Yan; Cui, Zhong-li

    2013-07-01

    A novel Gram-negative, non-spore-forming, rod-shaped strain, H1(T), was isolated from activated sludge by micromanipulation. No close relatives among cultured bacterial isolates were found; phylogenetic analysis based on 16S rRNA gene sequences revealed that strain H1(T) forms a deep single branch in the family Rhodospirillaceae. Cells of strain H1(T) were slightly curved to straight rods (1.2-1.4 × 1.5-1.7 µm) and motile by a single polar flagellum. Strain H1(T) was able to grow in the presence of 0-4 % NaCl and grew optimally at 37 °C and pH 6.0-7.0. Chemotaxonomic analysis revealed that strain H1(T) possessed Q-10 as the predominant ubiquinone and C18 : 1ω7c, C16 : 0 and C19 : 0 cyclo ω8c as the major fatty acids. The DNA G+C content of strain H1(T) was 65.1 mol%. Comparative analysis of 16S rRNA gene sequences, and phenotypic and chemotaxonomic data, indicate that strain H1(T) should represent a novel genus and species of the family Rhodospirillaceae. The name Taonella mepensis gen. nov., sp. nov. is proposed. The type strain of Taonella mepensis is H1(T) ( = CICC 10529(T) = CCTCC AB 2012861(T) = KACC 16940(T)).

  10. Impact of Combat Deployment and Posttraumatic Stress Disorder on Newly Reported Coronary Heart Disease Among US Active Duty and Reserve Forces

    DTIC Science & Technology

    2014-05-06

    activity, which may lead to the development of coronary atherosclerosis by invoking low-grade systemic proinflamma- tion, arterial intimal injury...veterans during the study period. Compared with a study of autopsy-based coro- nary atherosclerosis in US service members who died of com- bat or...Ebrahimi R. Post-traumatic stress disorder, coronary atherosclerosis , and mortality. Am J Cardiol. 2011;108:29–33. 6. Roger VL, Go AS, Lloyd-Jones DM

  11. Dissolution of bedded rock salt: A seismic profile across the active eastern margin of the Hutchinson Salt Member, central Kansas

    USGS Publications Warehouse

    Anderson, N.L.; Hopkins, J.; Martinez, A.; Knapp, R.W.; Macfarlane, P.A.; Watney, W.L.; Black, R.

    1994-01-01

    Since late Tertiary, bedded rock salt of the Permian Hutchinson Salt Member has been dissolved more-or-less continuously along its active eastern margin in central Kansas as a result of sustained contact with unconfined, undersaturated groundwater. The associated westward migration of the eastern margin has resulted in surface subsidence and the contemporaneous sedimentation of predominantly valley-filling Quarternary alluvium. In places, these alluvium deposits extend more than 25 km to the east of the present-day edge of the main body of contiguous rock salt. The margin could have receded this distance during the past several million years. From an environmental perspective, the continued leaching of the Hutchinson Salt is a major concern. This predominantly natural dissolution occurs in a broad zone across the central part of the State and adversely affects groundwater and surface-water quality as nonpoint source pollution. Significant surface subsidence occurs as well. Most of these subsidence features have formed gradually; others developed in a more catastrophic manner. The latter in particular pose real threats to roadways, railways, and buried oil and gas pipelines. In an effort to further clarify the process of natural salt dissolution in central Kansas and with the long-term goal of mitigating the adverse environmental affects of such leaching, the Kansas Geological Survey acquired a 4-km seismic profile across the eastern margin of the Hutchinson Salt in the Punkin Center area of central Kansas. The interpretation of these seismic data (and supporting surficial and borehole geologic control) is consistent with several hypotheses regarding the process and mechanisms of dissolution. More specifically these data support the theses that: 1. (1) Dissolution along the active eastern margin of the Hutchinson Salt Member was initiated during late Tertiary. Leaching has resulted in the steady westward migration of the eastern margin, surface subsidence, and the

  12. Light Duty Vehicle Program

    EPA Pesticide Factsheets

    View a fact sheet on how the Final Endangerment Finding will allow EPA to finalize the first greenhouse gas standards for new light-duty vehicles as part of the joint rulemaking with the Department of Transportation.

  13. Interplay between TAp73 Protein and Selected Activator Protein-1 (AP-1) Family Members Promotes AP-1 Target Gene Activation and Cellular Growth.

    PubMed

    Subramanian, Deepa; Bunjobpol, Wilawan; Sabapathy, Kanaga

    2015-07-24

    Unlike p53, which is mutated at a high rate in human cancers, its homologue p73 is not mutated but is often overexpressed, suggesting a possible context-dependent role in growth promotion. Previously, we have shown that co-expression of TAp73 with the proto-oncogene c-Jun can augment cellular growth and potentiate transactivation of activator protein (AP)-1 target genes such as cyclin D1. Here, we provide further mechanistic insights into the cooperative activity between these two transcription factors. Our data show that TAp73-mediated AP-1 target gene transactivation relies on c-Jun dimerization and requires the canonical AP-1 sites on target gene promoters. Interestingly, only selected members of the Fos family of proteins such as c-Fos and Fra1 were found to cooperate with TAp73 in a c-Jun-dependent manner to transactivate AP-1 target promoters. Inducible expression of TAp73 led to the recruitment of these Fos family members to the AP-1 target promoters on which TAp73 was found to be bound near the AP-1 site. Consistent with the binding of TAp73 and AP-1 members on the target promoters in a c-Jun-dependent manner, TAp73 was observed to physically interact with c-Jun specifically at the chromatin via its carboxyl-terminal region. Furthermore, co-expression of c-Fos or Fra1 was able to cooperate with TAp73 in potentiating cellular growth, similarly to c-Jun. These data together suggest that TAp73 plays a vital role in activation of AP-1 target genes via direct binding to c-Jun at the target promoters, leading to enhanced loading of other AP-1 family members, thereby leading to cellular growth.

  14. Impact of childhood maltreatment on physical health-related quality of life in U.S. active duty military personnel and combat veterans.

    PubMed

    Aversa, Laura H; Lemmer, Jennifer; Nunnink, Sarah; McLay, Robert N; Baker, Dewleen G

    2014-08-01

    Previous studies have found an association between childhood maltreatment (CM) and health-related quality of life (HRQoL), and to a lesser extent have considered whether psychiatric symptoms may explain the relationship. This study aimed to further our understanding of the link between CM and HRQoL by testing whether posttraumatic stress disorder (PTSD) or depressive symptoms mediate the relationship between childhood maltreatment and physical HRQoL. Mediation models were examined in a sample of male Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) active duty and combat veterans (n=249). PTSD and depressive symptoms mediated the relationship between CM and overall physical HRQoL, as well as participation in daily activities due to physical health, bodily pain, and social functioning. Mediation of the relationship between childhood maltreatment and physical and social functioning by depression and PTSD symptoms may lend support to neurobiological hypotheses that childhood maltreatment sensitizes the nervous system and after repeated trauma may lead to the development of psychiatric symptoms, which have a major impact on morbidity and mortality.

  15. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... while she is giving a speech at a political fundraiser. Example 3: The head of an executive department... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in political activity while... (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) POLITICAL ACTIVITIES OF FEDERAL EMPLOYEES...

  16. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members.

    PubMed Central

    Frost, J A; Xu, S; Hutchison, M R; Marcus, S; Cobb, M H

    1996-01-01

    The mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that are regulated by distinct extracellular stimuli. The currently known members include extracellular signal-regulated protein kinase 1 (ERK1), ERK2, the c-Jun N-terminal kinase/stress-activated protein kinases (JNK/SAPKs), and p38 MAP kinases. We find that overexpression of the Ste20-related enzymes p21-activated kinase 1 (PAK1) and PAK2 in 293 cells is sufficient to activate JNK/SAPK and to a lesser extent p38 MAP kinase but not ERK2. Rat MAP/ERK kinase kinase 1 can stimulate the activity of each of these MAP kinases. Although neither activated Rac nor the PAKs stimulate ERK2 activity, overexpression of either dominant negative Rac2 or the N-terminal regulatory domain of PAK1 inhibits Ras-mediated activation of ERK2, suggesting a permissive role for Rac in the control of the ERK pathway. Furthermore, constitutively active Rac2, Cdc42hs, and RhoA synergize with an activated form of Raf to increase ERK2 activity. These findings reveal a previously unrecognized connection between Rho family small G proteins and the ERK pathway. PMID:8668187

  17. TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function.

    PubMed

    Wu, Mengrui; Wang, Yiping; Deng, Lianfu; Chen, Wei; Li, Yi-Ping

    2012-01-01

    Osteoclasts are the principle bone-resorbing cells. Precise control of balanced osteoclast activity is indispensable for bone homeostasis. Osteoclast activation mediated by RANK-TRAF6 axis has been clearly identified. However, a negative regulation-machinery in osteoclast remains unclear. TRAF family member-associated NF-κB activator (TANK) is induced by about 10 folds during osteoclastogenesis, according to a genome-wide analysis of gene expression before and after osteoclast maturation, and confirmed by western blot and quantitative RT-PCR. Bone marrow macrophages (BMMs) transduced with lentivirus carrying tank-shRNA were induced to form osteoclast in the presence of RANKL and M-CSF. Tank expression was downregulated by 90% by Tank-shRNA, which is confirmed by western blot. Compared with wild-type (WT) cells, osteoclastogenesis of Tank-silenced BMMs was increased, according to tartrate-resistant acid phosphatase (TRAP) stain on day 5 and day 7. Number of bone resorption pits by Tank-silenced osteoclasts was increased by 176% compared with WT cells, as shown by wheat germ agglutinin (WGA) stain and scanning electronic microscope (SEM) analysis. Survival rate of Tank-silenced mature osteoclast is also increased. However, acid production of Tank-knockdown cells was not changed compared with control cells. IκBα phosphorylation is increased in tank-silenced cells, indicating that TANK may negatively regulate NF-κB activity in osteoclast. In conclusion, Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-κB activity and c-FLIP expression. Tank enrolls itself in a negative feedback loop in bone resorption. These results may provide means for therapeutic intervention in diseases of excessive bone resorption.

  18. Combination of Active Instability Control and Passive Measures to Prevent Combustion Instabilities in a 260MW Heavy Duty Gas Turbine

    DTIC Science & Technology

    2001-06-01

    UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADPO 11146 TITLE: Combination of Active Instability Control and Passive...ADPO11101 thru ADP011178 UNCLASSIFIED 3 -1 Combination of Active Instability Control and Passive Measures to Prevent Combustion Instabilities in a 260MW...Military Aircrqft, Land Vehicles and Sea Vehicles held in Braunschweig, Germany, 8-11 May 2000, and published in RTO MP-051. 3 -2 tuation produces the

  19. 46 CFR 11.524 - Service requirements for national endorsement as designated duty engineer (DDE) of steam, motor...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... qualified member of the engine department or equivalent position; (2) For designated duty engineer of steam... engine department or equivalent position; and (3) For designated duty engineer of steam, motor, and/or... designated duty engineer (DDE) of steam, motor, and/or gas turbine-propelled vessels. 11.524 Section...

  20. Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development

    PubMed Central

    Brown, J. Lesley; Kassis, Judith A.

    2010-01-01

    The Polycomb group of proteins (PcG) is important for transcriptional repression and silencing in all higher eukaryotes. In Drosophila, PcG proteins are recruited to the DNA by Polycomb-group response elements (PREs), regulatory sequences whose activity depends on the binding of many different sequence-specific DNA-binding proteins. We previously showed that a binding site for the Sp1/KLF family of zinc-finger proteins is required for PRE activity. Here, we report that the Sp1/KLF family member Spps binds specifically to Ubx and engrailed PREs, and that Spps binds to polytene chromosomes in a pattern virtually identical to that of the PcG protein, Psc. A deletion of the Spps gene causes lethality late in development and a loss in pairing-sensitive silencing, an activity associated with PREs. Finally, the Spps mutation enhances the phenotype of pho mutants. We suggest that Spps may work with, or in parallel to, Pho to recruit PcG protein complexes to PREs. PMID:20627963

  1. New 15-membered tetraaza (N4) macrocyclic ligand and its transition metal complexes: Spectral, magnetic, thermal and anticancer activity

    NASA Astrophysics Data System (ADS)

    El-Boraey, Hanaa A.; EL-Gammal, Ohyla A.

    2015-03-01

    Novel tetraamidemacrocyclic 15-membered ligand [L] i.e. naphthyl-dibenzo[1,5,9,12]tetraazacyclopentadecine-6,10,11,15-tetraoneand its transition metal complexes with Fe(II), Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On the basis of analytical, spectral (IR, MS, UV-Vis, 1H NMR and EPR) and thermal studies distorted octahedral or square planar geometry has been proposed for the complexes. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50 = 2.27-2.7, 8.33-31.1 μg/mL, respectively) showed potent antitumor activity, towards the former cell lines comparable with their ligand (IC50 = 13, 26 μg/mL, respectively). The results show that the activity of the ligand towards breast cancer cell line becomes more pronounced and significant when coordinated to the metal ion.

  2. Wrist activity monitoring in air crew members: a method for analyzing sleep quality following transmeridian and north-south flights.

    PubMed

    Buck, A; Tobler, I; Borbély, A A

    1989-01-01

    Home base recordings of motor activity during bedtime, and of subjective sleep parameters, were obtained from air crew members before and after the following routes with multiple flight segments: (1) south-north (SN) across 1 time zone; (2) west-east (WE) across 17 time zones; (3) east-west (EW) across 7 time zones. For the EW route, recordings were also obtained during layover. Only after return from the EW route was bedtime motor activity (measured by a wrist-worn ambulatory monitor) enhanced, was the percentage of bedtime immobility periods reduced, and were frequency and duration of self-assessed waking after sleep onset increased. The subjects rated their sleep as less quiet and felt less rested than during baseline. The various parameters gradually reverted toward baseline during the first 4 days at home. Although sleep showed only minor impairments during the EW route, the subjective jet-lag score was high during layover and after return to home base. Ambulatory activity monitoring is a useful method for assessing sleep quality after long-haul flights.

  3. Military service absences and family members' mental health: A timeline followback assessment.

    PubMed

    Rodriguez, Aubrey J; Margolin, Gayla

    2015-08-01

    Although military service, and particularly absence due to deployment, has been linked to risk for depression and anxiety among some spouses and children of active duty service members, there is limited research to explain the heterogeneity in family members' reactions to military service stressors. The current investigation introduces the Timeline Followback Military Family Interview (TFMFI) as a clinically useful strategy to collect detailed time-linked information about the service member's absences. Two dimensions of parent absence--the extent to which absences coincide with important family events and cumulative time absent--were tested as potential risks to family members' mental health. Data from 70 mother-adolescent pairs revealed that the number of important family events missed by the service member was linked to elevated youth symptoms of depression, even when accounting for the number of deployments and cumulative duration of the service member's absence. However, youth who reported more frequent contact with the service member during absences were buffered from the effects of extensive absence. Mothers' symptoms were associated with the cumulative duration of the service members' time away, but not with family events missed by the service member. These results identify circumstances that increase the risk for mental health symptoms associated with military family life. The TFMFI provides an interview-based strategy for clinicians wishing to understand military family members' lived experience during periods of service-member absence.

  4. 19 CFR 122.75b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Electronic manifest requirement for crew members... THE TREASURY AIR COMMERCE REGULATIONS Documents Required for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  5. 19 CFR 122.49b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Electronic manifest requirement for crew members... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  6. 19 CFR 122.49b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and time specified in paragraph (b)(2) of this section by means of an electronic data interchange... 19 Customs Duties 1 2011-04-01 2011-04-01 false Electronic manifest requirement for crew members...; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  7. 19 CFR 122.75b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... electronic data interchange system approved by CBP and must set forth the information specified in paragraph... 19 Customs Duties 1 2012-04-01 2012-04-01 false Electronic manifest requirement for crew members...; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  8. 19 CFR 122.75b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... electronic data interchange system approved by CBP and must set forth the information specified in paragraph... 19 Customs Duties 1 2011-04-01 2011-04-01 false Electronic manifest requirement for crew members...; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  9. 19 CFR 122.75b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... electronic data interchange system approved by CBP and must set forth the information specified in paragraph... 19 Customs Duties 1 2013-04-01 2013-04-01 false Electronic manifest requirement for crew members...; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  10. 19 CFR 122.75b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Electronic manifest requirement for crew members... THE TREASURY AIR COMMERCE REGULATIONS Documents Required for Clearance and Permission To Depart; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  11. 19 CFR 122.49b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Electronic manifest requirement for crew members... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  12. 19 CFR 122.49b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Electronic manifest requirement for crew members... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  13. 19 CFR 122.49b - Electronic manifest requirement for crew members and non-crew members onboard commercial aircraft...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Electronic manifest requirement for crew members...; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within, and Overflying the United States § 122.49b Electronic...

  14. The relationship between heavy alcohol use and work productivity loss in active duty military personnel: a secondary analysis of the 1995 Department of Defense Worldwide Survey.

    PubMed

    Fisher, C A; Hoffman, K J; Austin-Lane, J; Kao, T C

    2000-05-01

    This cross-sectional study examines the association between heavy alcohol use among active duty military personnel and five work productivity loss events that may have an adverse effect on military performance and readiness. Data for light (N = 3,147) and heavy (N = 2,242) drinkers, categorized by gender and pay grade, were obtained from the 1995 Department of Defense Worldwide Survey. Drinking classification was predefined using a standard algorithm that factored quantity and frequency of wine, beer, and liquor consumed. The relative risks of experiencing a productivity loss event at a particular level and 95% confidence intervals were calculated by applying the Mantel-Haenszel method after adjusting for age. The relative risks for increased self-reported lateness, leaving early, low performance, and on-the-job injury were all higher for heavy drinkers than for light drinkers. This association between the heavy-drinking population and four of five work productivity loss events indicates that prevention programs should target all personnel.

  15. Laterally coupled distributed feedback lasers emitting at 2 μm with quantum dash active region and high-duty-cycle etched semiconductor gratings

    NASA Astrophysics Data System (ADS)

    Papatryfonos, Konstantinos; Saladukha, Dzianis; Merghem, Kamel; Joshi, Siddharth; Lelarge, Francois; Bouchoule, Sophie; Kazazis, Dimitrios; Guilet, Stephane; Le Gratiet, Luc; Ochalski, Tomasz J.; Huyet, Guillaume; Martinez, Anthony; Ramdane, Abderrahim

    2017-02-01

    Single-mode diode lasers on an InP(001) substrate have been developed using InAs/In0.53Ga0.47As quantum dash (Qdash) active regions and etched lateral Bragg gratings. The lasers have been designed to operate at wavelengths near 2 μm and exhibit a threshold current of 65 mA for a 600 μm long cavity, and a room temperature continuous wave output power per facet >5 mW. Using our novel growth approach based on the low ternary In0.53Ga0.47As barriers, we also demonstrate ridge-waveguide lasers emitting up to 2.1 μm and underline the possibilities for further pushing the emission wavelength out towards longer wavelengths with this material system. By introducing experimentally the concept of high-duty-cycle lateral Bragg gratings, a side mode suppression ratio of >37 dB has been achieved, owing to an appreciably increased grating coupling coefficient of κ ˜ 40 cm-1. These laterally coupled distributed feedback (LC-DFB) lasers combine the advantage of high and well-controlled coupling coefficients achieved in conventional DFB lasers, with the regrowth-free fabrication process of lateral gratings, and exhibit substantially lower optical losses compared to the conventional metal-based LC-DFB lasers.

  16. Pilot study to determine interest of adult civilian dependents of active duty military personnel in participation in a weight control program.

    PubMed

    Bukhari, Asma; Roberts, Susan B; Young, Andrew J; McGraw, Susan; Dallal, Gerard E; Das, Sai Krupa

    2014-03-01

    Adult civilian dependents of active duty military personnel (ADMP) may play a central role in influencing the home food environment and the risk of overweight and obesity in American Warfighters and military families. However, there is no information on whether this group would be receptive to weight control programs. We conducted a survey to determine the level of interest of adult civilian dependents of ADMP in participating in a group weight control program. Subjects were a convenience sample of 191 adult civilian dependents of ADMP (94% women, 6% men) based in Massachusetts and aged 33.8 ± 8.4 years, body mass index 25.5 ± 5.5 kg/m(2). Overall, there was a significant effect of body mass index on interest in program participation (p = 0.004). Eighty five percent of overweight participants and 100% of obese participants reported being Moderately Likely or Very Likely to participate in a provided weight control program. In overweight and obese survey respondents there was no significant effect of ADMP rank on interest in program participation (p = 0.34). These findings suggest that overweight and obese adult civilian dependents of ADMP may be very receptive targets for programs to control overweight and obesity in military families.

  17. Understanding diet and modeling changes in the omega-3 and omega-6 fatty acid composition of U.S. garrison foods for active duty personnel.

    PubMed

    Marriott, Bernadette P; Yu, Karina; Majchrzak-Hong, Sharon; Johnson, Jeremiah; Hibbeln, Joseph R

    2014-11-01

    Research indicates that dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are important in reducing the risk of mental illness. We used the DoD Survey of Health Related Behaviors among Active Duty Military Personnel (HRBS) to assess current military dietary patterns and meal locations. We used the Lands Equation to model PUFAs in a sample Garrison diet and the nutritional impact of substitution of foods higher in omega-3 PUFAs and lower in omega-6 PUFAs on tissue composition. The military diet was very poor quality compared to 2010 Healthy People Guidelines. A representative Garrison diet does not meet our estimated healthy n-3 HUFA intake at 3.5 g/d, corresponding with a tissue composition of 60% n-3 in HUFA (i.e., 40% n-6 in HUFA). Substitution of n-3 rich eggs, poultry, pork and other food commodities, combined with use on low linoleic acid oils, may contribute significantly to attaining healthier n-6/n-3 proportions in the tissue.

  18. Elastomeric member

    DOEpatents

    Hoppie, L.O.

    1985-07-30

    An energy storage device is disclosed consisting of a stretched elongated elastomeric member disposed within a tubular housing, which elastomeric member is adapted to be torsionally stressed to store energy. The elastomeric member is configured in the relaxed state with a uniform diameter body section, and transition end sections, attached to rigid end piece assemblies of a lesser diameter. The profile and deflection characteristic of the transition sections are such that upon stretching of the elastomeric member, a substantially uniform diameter assembly results, to minimize the required volume of the surrounding housing. Each of the transition sections are received within and bonded to a woven wire mesh sleeve having helical windings at a particular helix angle to control the deflection of the transition section. Each sleeve also contracts with the contraction of the associated transition section to maintain the bond there between. During manufacture, the sleeves are forced against a forming surface and bonded to the associated transition section to provide the correct profile and helix angle. 12 figs.

  19. Elastomeric member

    DOEpatents

    Hoppie, Lyle O.

    1985-01-01

    An energy storage device (10) is disclosed consisting of a stretched elongated elastomeric member (16) disposed within a tubular housing (14), which elastomeric member (16) is adapted to be torsionally stressed to store energy. The elastomeric member (16) is configured in the relaxed state with a uniform diameter body section (74), and transition end sections (76, 78), attached to rigid end piece assemblies (22, 24) of a lesser diameter. The profile and deflection characteristic of the transition sections (76, 78) are such that upon stretching of the elastomeric member (16), a substantially uniform diameter assembly results, to minimize the required volume of the surrounding housing (14). Each of the transition sections (76, 78) are received within and bonded to a woven wire mesh sleeve (26, 28) having helical windings at a particular helix angle to control the deflection of the transition section. Each sleeve (26, 28) also contracts with the contraction of the associated transition section to maintain the bond therebetween. During manufacture, the sleeves (26, 28) are forced against a forming surface and bonded to the associated transition section (76, 78) to provide the correct profile and helix angle.

  20. Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma

    PubMed Central

    Jorgensen, Marda; Song, Joanna; Zhou, Junmei; Liu, Chen

    2016-01-01

    Hepatic stem/progenitor cells (HPC) reside quiescently in normal biliary trees and are activated in the form of ductular reactions during severe liver damage when the replicative ability of hepatocytes is inhibited. HPC niches are full of profibrotic stimuli favoring scarring and hepatocarcinogenesis. The Cyr61/CTGF/NOV (CCN) protein family consists of six members, CCN1/CYR61, CCN2/CTGF, CCN3/NOV, CCN4/WISP1, CCN5/WISP2, and CCN6/WISP3, which function as extracellular signaling modulators to mediate cell-matrix interaction during angiogenesis, wound healing, fibrosis, and tumorigenesis. This study investigated expression patterns of CCN proteins in HPC and cholangiocarcinoma (CCA). Mouse HPC were induced by the biliary toxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). Differential expression patterns of CCN proteins were found in HPC from DDC damaged mice and in human CCA tumors. In addition, we utilized reporter mice that carried Ccn2/Ctgf promoter driven GFP and detected strong Ccn2/Ctgf expression in epithelial cell adhesion molecule (EpCAM)+ HPC under normal conditions and in DDC-induced liver damage. Abundant CCN2/CTGF protein was also found in cytokeratin 19 (CK19)+ human HPC that were surrounded by α-smooth muscle actin (α-SMA)+ myofibroblast cells in intrahepatic CCA tumors. These results suggest that CCN proteins, particularly CCN2/CTGF, function in HPC activation and CCA development. PMID:27829832

  1. Supporting members

    NASA Astrophysics Data System (ADS)

    Life Supporting Members L. Thomas Aldrich Thomas D. Barrow Hugh J . A. Chivers Allan V. Cox Samuel S. Goldich Pembroke J. Hart A. Ivan Johnson Helmut E. Landsberg Paolo Lanzano Murli H. Manghnani L. L. Nettleton Charles B. Officer Hyman Orlin Ned A. Ostenso Erick O. Schonstedt Waldo E. Smith Athelstan Spilhaus A. F. Spilhaus, Jr. John W. Townsend, Jr. James A. Van Allen Leonard W. Weis Charles A. Whitten J. Tuzo Wilson

  2. 77 FR 73911 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... calculation errors present in that document, and presents sensitivity analysis on key assumptions used in the... sensitivity analysis on key assumptions used in the analysis.\\1\\ A new Appendix B contains the results of those sensitivity analyses while Appendix C contains detailed data tables, which are summarized in...

  3. 75 FR 63424 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... of operations and the universality of factors that lead to fatigue in most individuals. Fatigue... carriers to submit a Fatigue Risk Management Plan to the FAA by October 30, 2010, will take time...

  4. 75 FR 62486 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... you wish to submit a request to the FAA for clarification of the NPRM (Docket Number FAA-2009-1093...://www.regulations.gov , enter Docket Number FAA 2009-1093, and follow the online instructions...

  5. 7 CFR 924.27 - Alternate members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... such other duties as assigned. In the event of the death, removal, resignation, or disqualification of... qualified. In the event both a member of the committee and his alternate are unable to attend a...

  6. Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily

    SciTech Connect

    Gajewski, Stefan; Comeaux, Evan Q.; Jafari, Nauzanene; Bharatham, Nagakumar; Bashford, Donald; White, Stephen W.; van Waardenburg, Robert C.A.M.

    2012-03-15

    Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines - one acting as the lead nucleophile and the second acting as a general acid/base. Substitution of the second histidine specifically to arginine contributes to the neurodegenerative disease spinocerebellar ataxia with axonal neuropathy (SCAN1). We investigated the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crystallography, biochemistry, yeast genetics, and theoretical chemistry. The structures of wild-type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn. The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts the access of nucleophilic water molecule to the Tdp1-DNA intermediate. Biochemical analyses confirm that His432Arg forms an observable and unique Tdp1-DNA adduct during catalysis. Substitution of His432 by Lys does not affect catalytic activity or yeast phenotype, but substitutions with Asn, Gln, Leu, Ala, Ser, and Thr all result in severely compromised enzymes and DNA topoisomerase I-camptothecin dependent lethality. Surprisingly, His432Asn did not show a stable covalent Tdp1-DNA intermediate that suggests another catalytic defect. Theoretical calculations revealed that the defect resides in the nucleophilic histidine and that the pK{sub a} of this histidine is crucially dependent on the second histidine and on the incoming phosphate of the substrate. This represents a unique example of substrate-activated catalysis that applies to the entire phospholipase D superfamily.

  7. Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.

    PubMed

    Brouxhon, Sabine M; Kyrkanides, Stephanos; Teng, Xiaofei; O'Banion, M Kerry; Clarke, Robert; Byers, Stephen; Ma, Li

    2014-11-01

    Recent literature suggests that sEcad exerts pro-oncogenic effects, possibly acting as a ligand for the human epidermal growth factor family. Here we show that sEcad is a novel candidate protein for drug targeting since it is increased in human and mouse HER2-positive (HER2+) breast tumors, MMTV-PyMT bodily fluids and human cell culture systems. Mechanistically, we show that endogenous sEcad, and to a lesser extent membrane-bound E-cadherin, associates with HER1, HER2, and HER3 in human and MMTV-PyMT mouse HER2+ tumors and with HER1 in triple negative breast cancer (TNBC) specimens. Furthermore, addition of exogenous recombinant human E-cadherin/Fc chimeric protein (rhEcad/Fc; sEcad) to HER2+ MCF-7, SKBR3, and HER2-negative MDA-MB-231 TNBC cells, resulted in sEcad-HER receptor family interactions, activation of HER1-4 and downstream pro-survival signaling, including the MAPK-PI3K/Akt/mTOR pathways and IAP family members. Lastly, we demonstrate that sEcad exerts pro-oncogenic effects via HER signaling, and acts additively with the HER ligand EGF to promote HER2+ breast cancer proliferation and migration, as well as TNBC invasion. Because sEcad associates and activates many of the oncogenic pathways that tumors utilize for growth and survival and serum levels in patients correlates with clinical response, suggests that targeted therapy against sEcad in combination with other therapies may potentially offer a novel therapeutic strategy for the treatment of breast cancers.

  8. Balancing Duties and Rights.

    ERIC Educational Resources Information Center

    McCarthy, Martha M.; Webb, L. Dean

    2000-01-01

    Schools are legally obligated to protect students from injury, report child abuse, and curtail harassment and hate crimes. Educators' duties to maintain safe school environments often conflict with students' constitutionally protected rights governing expression, appearance, unreasonable searches, and due process regarding zero-tolerance policies…

  9. Cost Analysis of a Transition to Green Vehicle Technology for Light Duty Fleet Vehicles in Public Works Department Naval Support Activity Monterey (PWD Monterey)

    DTIC Science & Technology

    2015-12-01

    both overall life- cycle vehicle costs and carbon emissions. The focus is on light-duty, non-tactical vehicles in use in the region. The cost analysis...both overall life- cycle vehicle costs and carbon emissions. The focus is on light- duty, non-tactical vehicles in use in the region. The cost analysis...in accordance with ICE – Internal Combustion Engine INEL – Idaho National Energy Laboratory JBLM – Joint Base Lewis-McChord LCC – life cycle cost

  10. Cloning and expression of a transcription factor activator protein-1 (AP-1) member identified from manila clam Venerupis philippinarum.

    PubMed

    Wu, Luning; Zhang, Lei; Zhao, Jianmin; Ning, Xuanxuan; Mu, Changkao; Wang, Chunlin

    2015-02-15

    The transcription factor activator protein-1 (AP-1) proteins are implicated to play a major role in the regulation of numerous genes involved in the function and development of the immune system, cell differentiation, proliferation, apoptosis, etc. It can bind to promoter of its target genes in a sequence-specific manner to transactivate or repress them. In this study, the full-length cDNA of an AP-1 was identified from Venerupis philippinarum (denoted as VpAP-1) by EST analysis and RACE approaches. Phylogenetic analysis indicated that VpAP-1 had higher evolutional conservation to invertebrate than vertebrate counterparts and should be a new member of the AP-1 protein family. Spatial expression analysis found that VpAP-1 transcript was most abundantly expressed in the hemocytes and hepatopancreas, weakly expressed in the tissues of the gills, mantle and muscle. After Vibrio anguillarum challenge, the expression of VpAP-1 transcript in overall hemocyte population was up-regulated in the first 6h, and then decreased to 1.5-fold of the control group at 12h. As time progressed, a second peak of VpAP-1 expression was detected at 24h post-infection, which was 5-fold compared with that of the control group (P<0.01). After that, the expression level was sharply decreased and dropped to 0.5-fold of the control at 96h. The above results indicated that VpAP-1 was perhaps involved in the immune responses against microbe infection and might be contributed to the clearance of bacterial pathogens.

  11. Light Duty Efficient, Clean Combustion

    SciTech Connect

    Donald Stanton

    2010-12-31

    aftertreatment engine; (5) Emissions and efficiency targets were reached with the use of biodiesel. A variety of biofuel feedstocks (soy, rapeseed, etc.) was investigated; (6) The advanced LDECC engine with low temperature combustion was compatible with commercially available biofuels as evaluated by engine performance testing and not durability testing; (7) The advanced LDECC engine equipped with a novel SCR aftertreatment system is the engine system architecture that is being further developed by the Cummins product development organization. Cost reduction and system robustness activities have been identified for future deployment; (8) The new engine and aftertreatment component technologies are being developed by the Cummins Component Business units (e.g. fuel system, turbomachinery, aftertreatment, electronics, etc.) to ensure commercial viability and deployment; (9) Cummins has demonstrated that the technologies developed for this program are scalable across the complete light duty engine product offerings (2.8L to 6.7L engines); and (10) Key subsystems developed include - sequential two stage turbo, combustions system for low temperature combustion, novel SCR aftertreatment system with feedback control, and high pressure common rail fuel system. An important element of the success of this project was leveraging Cummins engine component technologies. Innovation in component technology coupled with system integration is enabling Cummins to move forward with the development of high efficiency clean diesel products with a long term goal of reaching a 40% improvement in thermal efficiency for the engine plus aftertreatment system. The 40% improvement is in-line with the current light duty vehicle efficiency targets set by the 2010 DoE Vehicle Technologies MYPP and supported through co-operative projects such as the Cummins Advanced Technology Powertrains for Light-Duty Vehicles (ATP-LD) started in 2010.

  12. Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine.

    PubMed

    Evans, Stella R; Thoreson, Wallace B; Beck, Carol L

    2004-10-01

    Two new calcium-activated chloride channel (CLCA) family members, mCLCA5 and mCLCA6, have been cloned from mouse eye and intestine, respectively. mCLCA5 is highly homologous to hCLCA2, and mCLCA6 is highly homologous to hCLCA4. mCLCA5 is widely expressed with strong expression in eye and spleen, whereas mCLCA6 is primarily expressed in intestine and stomach. mCLCA6 is also expressed as a splice variant lacking exon 8 and part of exon 10 in intestine and stomach. Transfection of tsA201 cells with enhanced green fluorescent protein-tagged versions of the three cDNAs reveals protein products of 155 and 65 kDa for mCLCA5 and mCLCA6 and 145 and 65 kDa for the mCLCA6 splice variant. In vitro translation of mCLCA5 generates a 90-kDa protein that does not appear to be glycosylated. mCLCA6 also generates a 90-kDa protein that is glycosylated to a 110-kDa product, whereas the mCLCA6 splice variant generates an 80-kDa product that is 100 kDa after glycosylation. Treatment of enhanced green fluorescent protein-tagged mCLCA6 with PNGase F (peptide: N-glycosidase F) to remove N-linked glycosyl groups shows a reduction in size of the 65 kDa product to 60 kDa. Consistent with the hypothesis that mCLCA5, mCLCA6, and its splice variant encode calcium-activated chloride channels, in HEK293 cells expressing CLCAs ionomycin-evoked increases in intracellular calcium stimulated a current that reversed near Cl(-) equilibrium potential, E(Cl). Furthermore, these currents were inhibited by the chloride channel blocker niflumic acid. Given the prominent role of hCLCA2 in cancer cell adhesion and the unique high level of expression of hCLCA4 in brain, the identification of their murine counterparts presents the opportunity to clarify the role of CLCAs in disease and normal cell physiology.

  13. Studies toward the Unique Pederin Family Member Psymberin: Structure Activity Relationships, Biochemical Studies and Genetics Identify the Mode of Action of Psymberin

    PubMed Central

    Wu, Cheng-Yang; Feng, Yu; Cardenas, Eduardo R.; Williams, Noelle; Floreancig, Paul E.; De Brabander, Jef K.; Roth, Michael G.

    2012-01-01

    Psymberin is the only member of the pederin natural product family that contains a dihydroisocoumarin side chain. Structural modifications of psymberin uncoupled inhibition of protein translation from cytotoxicity, suggesting that psymberin has more than one bioactivity. A forward genetic screen in Caenorhabditis elegans was conducted to identify the molecular target(s) of psymberin. Multiple independent psymberin-resistant mutants were isolated, each containing the same point mutation in a gene encoding a ribosomal protein. However, a psymberin-resistant mutant strain bearing this mutation was not cross-resistant to the pederin family member mycalamide A, which binds to the archaeal form of the same protein. Thus, two pederin family members likely differ in how they bind the same molecular target. The accumulation of psymberin in cells was sensitive to the stereochemistry of the amide side chain at C4 or C8 and the presence of the dihydroisocoumarin side chain. The observation that psymberin diastereomers or dihydroisocoumarin-truncated analogs lose all cytotoxic activity while retaining the ability to inhibit protein translation in a cell-free in vitro assay can be explained in the context of these differential cell uptake issues. Finally, we also demonstrate that the blistering activity associated with pederin and other members of the family is not due to their protein synthesis inhibiting activity. Unlike pederin and mycalamide, psymberin does not display irritant or blistering activity. PMID:23088155

  14. Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.

    PubMed

    Wu, Cheng-Yang; Feng, Yu; Cardenas, Eduardo R; Williams, Noelle; Floreancig, Paul E; De Brabander, Jef K; Roth, Michael G

    2012-11-21

    Psymberin is the only member of the pederin natural product family that contains a dihydroisocoumarin side chain. Structural modifications of psymberin uncoupled inhibition of protein translation from cytotoxicity, suggesting that psymberin has more than one bioactivity. A forward genetic screen in Caenorhabditis elegans was conducted to identify the molecular target(s) of psymberin. Multiple independent psymberin-resistant mutants were isolated, each containing the same point mutation in a gene encoding a ribosomal protein. However, a psymberin-resistant mutant strain bearing this mutation was not cross-resistant to the pederin family member mycalamide A, which binds to the archaeal form of the same protein. Thus, two pederin family members likely differ in how they bind the same molecular target. The accumulation of psymberin in cells was sensitive to the stereochemistry of the amide side chain at C4 or C8 and the presence of the dihydroisocoumarin side chain. The observation that psymberin diastereomers or dihydroisocoumarin-truncated analogs lose all cytotoxic activity while retaining the ability to inhibit protein translation in a cell-free in vitro assay can be explained in the context of these differential cell uptake issues. Finally, we also demonstrate that the blistering activity associated with pederin and other members of the family is not due to their protein synthesis inhibiting activity. Unlike pederin and mycalamide, psymberin does not display irritant or blistering activity.

  15. Characterization of active members in C and N cycles in the subsurface environment of the Witwatersrand Basin

    NASA Astrophysics Data System (ADS)

    Lindsay, M. R.; Lau, C. M.; Tetteh, G.; Snyder, L.; Kieft, T. L.; Lollar, B. S.; Li, L.; Maphanga, S.; van Heerden, E.; Onstott, T. C.

    2012-12-01

    methanotrophs were found three times more than Type I methanotrophs. A pmoA gene sequence represents 42% of the library matches only and is identical to a putative protein sequence annotated on Ca. D. audaxviator genome, but further analysis is required to validate its candidature of methanotrophy. The cluster of mcrA gene sequences is related to a novel group of anaerobic methanotrophs (ANME) defined by environmental sequences. 2011 July samples from the same borehole revealed an absence of Firmicutes. Two β-Proteobacterial sequences dominated the bacterial 16S rDNA clone library, accounting for 54% and 25%. The first 16S rRNA clone library for the region confirmed a complete lack of Firmicutes with active Proteobacteria (71% α-, 17% β- and 6% γ-Proteobacteria). Only 3% of the active community is confidently inferred as methylotrophs while 22% belongs to N2 fixer Rhizobium sp. which has been demonstrated to stimulate methanotrophic growth and 28% is related to Polymorphum gilvum, which is known for n-alkane degradation. Active members responsible for CH4 metabolism will be supported by presenting the results of archaeal 16S rRNA, pmoA, mcrA and nitrogenase gene diversities. The lack of Firmicutes in July samples could be attributed to collection methods: different filter membrane, faster flowrate but shorter sampling duration, and less total volume of water filtered.

  16. Battery Ownership Model - Medium Duty HEV Battery Leasing & Standardization

    SciTech Connect

    Kelly, Ken; Smith, Kandler; Cosgrove, Jon; Prohaska, Robert; Pesaran, Ahmad; Paul, James; Wiseman, Marc

    2015-12-01

    Prepared for the U.S. Department of Energy, this milestone report focuses on the economics of leasing versus owning batteries for medium-duty hybrid electric vehicles as well as various battery standardization scenarios. The work described in this report was performed by members of the Energy Storage Team and the Vehicle Simulation Team in NREL's Transportation and Hydrogen Systems Center along with members of the Vehicles Analysis Team at Ricardo.

  17. 12 CFR 747.208 - Duties after termination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section 206(b) of the Act (12 U.S.C. 1786(b)), insurance of its member accounts to the extent they were... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Duties after termination. 747.208 Section 747... such termination shall be insured by the NCUA Board. (b) The credit union shall continue to...

  18. 12 CFR 747.208 - Duties after termination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... section 206(b) of the Act (12 U.S.C. 1786(b)), insurance of its member accounts to the extent they were... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Duties after termination. 747.208 Section 747... such termination shall be insured by the NCUA Board. (b) The credit union shall continue to...

  19. 12 CFR 747.208 - Duties after termination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... section 206(b) of the Act (12 U.S.C. 1786(b)), insurance of its member accounts to the extent they were... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Duties after termination. 747.208 Section 747... such termination shall be insured by the NCUA Board. (b) The credit union shall continue to...

  20. MILITARY PAY: Processes for Retaining Injured Army National Guard and Reserve Soldiers on Active Duty Have Been Improved, but Some Challenges Remain

    DTIC Science & Technology

    2007-05-01

    average length of stay of soldiers treated by civilian providers through CBHCI with the average length of stay of soldiers treated at MTFs...these metrics may be misleading. According to the Army’s metrics, the average length of stay , before being returned to duty or medically separated...for soldiers treated by civilian providers through CBHCI is 288 days whereas the average length of stay for soldiers

  1. Personality characteristics of Wikipedia members.

    PubMed

    Amichai-Hamburger, Yair; Lamdan, Naama; Madiel, Rinat; Hayat, Tsahi

    2008-12-01

    Wikipedia is an online, free access, volunteer-contributed encyclopedia. This article focuses on the Wikipedians' (Wikipedia users) personality characteristics, studying Wikipedians' conceptions of Real-Me and BFI dimensions. To survey these aspects, we posted links to two online web questionnaires; one was targeted at Wikipedians and the second to non-Wikipedia users. One hundred and thirty-nine subjects participated in the study, of which 69 were active Wikipedia members. It was found that Wikipedia members locate their real me on the Internet more frequently as compared to non-Wikipedia members. Variance analysis revealed significant differences between Wikipedia members and non-Wikipedia members in agreeableness, openness, and conscientiousness, which were lower for the Wikipedia members. An interaction was found between Wikipedia membership and gender: introverted women were more likely to be Wikipedia members as compared with extroverted women. The results of this study are discussed with special emphasis on the understanding of the motivators of Wikipedia members.

  2. 29 CFR 785.21 - Less than 24-hour duty.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Sleeping Time and Certain Other Activities § 785.21 Less than 24-hour duty. An employee who is required to... difference that she is furnished facilities for sleeping. Her time is given to her employer. She is...

  3. 29 CFR 785.21 - Less than 24-hour duty.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Sleeping Time and Certain Other Activities § 785.21 Less than 24-hour duty. An employee who is required to... difference that she is furnished facilities for sleeping. Her time is given to her employer. She is...

  4. 48 CFR 6.502 - Duties and responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION PLANNING COMPETITION REQUIREMENTS Competition Advocates 6.502 Duties and responsibilities. (a) Agency and procuring activity competition advocates are responsible for promoting the acquisition of commercial items, promoting full and open competition, challenging requirements that are not stated in...

  5. 29 CFR 785.21 - Less than 24-hour duty.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Sleeping Time and Certain Other Activities § 785.21 Less than 24-hour duty. An employee who is required to... difference that she is furnished facilities for sleeping. Her time is given to her employer. She is...

  6. 29 CFR 785.21 - Less than 24-hour duty.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Sleeping Time and Certain Other Activities § 785.21 Less than 24-hour duty. An employee who is required to... difference that she is furnished facilities for sleeping. Her time is given to her employer. She is...

  7. 29 CFR 785.21 - Less than 24-hour duty.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Sleeping Time and Certain Other Activities § 785.21 Less than 24-hour duty. An employee who is required to... difference that she is furnished facilities for sleeping. Her time is given to her employer. She is...

  8. Emergency Medical Technician Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for 12 duties in the occupation of emergency medical technician. Each duty is divided into a number of tasks. A separate page for each duty lists the task with its code number and columns to indicate whether that particular duty has been taught and to provide space for comments. The 12 duties…

  9. Auto Mechanics Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for eight occupations in the auto mechanics series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide…

  10. Residential Carpentry Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for nine occupations in the residential carpentry series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to…

  11. Data Processing Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for five occupations in the data processing series. Each occupation is divided into 5 to 11 duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide space…

  12. Occupational Food Service Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for six occupations in the occupational food service series. Each occupation is divided into three to eight duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and…

  13. Business & Office Secretarial Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for 11 occupations in the business and office secretarial series. Each occupation is divided into three to seven duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught…

  14. Diesel Mechanics Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for 11 occupations in the diesel mechanics series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide…

  15. Fashion Merchandising Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for seven occupations in the fashion merchandising series. Each occupation is divided into 6 to 15 duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to…

  16. Word Processing Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for two occupations in the word processing series. Each occupation is divided into 9 or 10 duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide space…

  17. Manganese(I)‐Catalyzed C−H Activation: The Key Role of a 7‐Membered Manganacycle in H‐Transfer and Reductive Elimination

    PubMed Central

    Yahaya, Nasiru P.; Appleby, Kate M.; Teh, Magdalene; Wagner, Conrad; Troschke, Erik; Bray, Joshua T. W.; Duckett, Simon B.; Hammarback, L. Anders; Ward, Jonathan S.; Milani, Jessica; Pridmore, Natalie E.; Whitwood, Adrian C.

    2016-01-01

    Abstract Manganese‐catalyzed C−H bond activation chemistry is emerging as a powerful and complementary method for molecular functionalization. A highly reactive seven‐membered MnI intermediate is detected and characterized that is effective for H‐transfer or reductive elimination to deliver alkenylated or pyridinium products, respectively. The two pathways are determined at MnI by judicious choice of an electron‐deficient 2‐pyrone substrate containing a 2‐pyridyl directing group, which undergoes regioselective C−H bond activation, serving as a valuable system for probing the mechanistic features of Mn C−H bond activation chemistry. PMID:27603008

  18. Human T-lymphotropic virus infections in active component service members, U.S. Armed Forces, 2000-2008.

    PubMed

    Petruccelli, Bruno P; Murray, Clinton K; Davis, Kenneth W; McBride, Richard; Peel, Sheila A; Michael, Nelson; Scott, Paul T; Hakre, Shilpa

    2014-02-01

    Emergency whole blood transfusions may increase the risk of transmitting bloodborne pathogens, including human T-lymphotropic viruses (HTLVs). U.S. military personnel with any medical encounter for HTLV infection during 2000-2013;2008 were identified from surveillance data. Using both inclusive and restrictive case definitions, the incidence of diagnoses of HTLV infection was analyzed in relation to demographic factors and prior deployment. There were 247 "possible" cases of HTLV infection identified, or 1.88 cases per 100,000 person-years (p-yrs) (95% CI 1.66, 2.13). Seventy of these met the restrictive definition, translating to a rate of 0.53 per 100,000 p-yrs (95% CI 0.42, 0.67). Under the restrictive definition, a higher rate was noted among females versus males (RR 2.37; 95% CI 1.41, 3.98), service members with a healthcare occupation versus those who are primarily trained to engage in combat (RR 2.54; 95% CI 1.06, 6.10), and service members with any deployment experience (RR 8.98; 95% CI 5.61, 14.37). These findings, and a prior military case report of transfusion-transmitted HTLV-I, suggest a need to better define the epidemiology of HTLV in U.S. military personnel to further ensure emergency transfusion safety.

  19. Air Force Chaplains' Perceived Effectiveness on Service Member's Resilience and Satisfaction.

    PubMed

    Cafferky, Bryan; Norton, Aaron; Travis, Wendy J

    2017-01-01

    This study examined how 3,777 active duty male United States Air Force service members' (SMs) rank and residence location moderated the associations between perceived chaplain effectiveness, SMs' resilience, family coping, marital satisfaction, and satisfaction with the Air Force (AF). A multiple-sample structural equation model was conducted with four subgroups of SMs who had received chaplain support: enlisted members living on base, enlisted members living off base, officers living on base, and officers living off base. Chaplain effectiveness was significantly related, both directly and indirectly, to SM's spirituality, resilience, family coping, marital satisfaction, and AF satisfaction. Resilience was significantly associated with increased AF satisfaction for all SMs, except for those living on base. However, living on base was found to strengthen the protective factor between family coping and relationship satisfaction. Rank was found to moderate the link between resilience and family coping. Family coping was significantly related to increased relationship satisfaction.

  20. Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site

    PubMed Central

    Xu, Qingping; Grant, Joanna; Chiu, Hsiu-Ju; Farr, Carol L.; Jaroszewski, Lukasz; Knuth, Mark W.; Miller, Mitchell D.; Lesley, Scott A.; Godzik, Adam; Elsliger, Marc-André; Deacon, Ashley M.; Wilson, Ian A.

    2014-01-01

    PF10014 is a novel family of 2-oxyglutarate-Fe2+-dependent dioxygenases that are involved in biosynthesis of antibiotics and regulation of biofilm formation, likely by catalyzing hydroxylation of free amino acids or other related ligands. The crystal structure of a PF10014 member from Methylibium petroleiphilum at 1.9 Å resolution shows strong structural similarity to cupin dioxygenases in overall fold and active site, despite very remote homology. However, one of the β-strands of the cupin catalytic core is replaced by a loop that displays conformational isomerism that likely regulates the active site. PMID:23852666

  1. Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site.

    PubMed

    Xu, Qingping; Grant, Joanna; Chiu, Hsiu-Ju; Farr, Carol L; Jaroszewski, Lukasz; Knuth, Mark W; Miller, Mitchell D; Lesley, Scott A; Godzik, Adam; Elsliger, Marc-André; Deacon, Ashley M; Wilson, Ian A

    2014-01-01

    PF10014 is a novel family of 2-oxyglutarate-Fe(2+) -dependent dioxygenases that are involved in biosynthesis of antibiotics and regulation of biofilm formation, likely by catalyzing hydroxylation of free amino acids or other related ligands. The crystal structure of a PF10014 member from Methylibium petroleiphilum at 1.9 Å resolution shows strong structural similarity to cupin dioxygenases in overall fold and active site, despite very remote homology. However, one of the β-strands of the cupin catalytic core is replaced by a loop that displays conformational isomerism that likely regulates the active site.

  2. Protein and messenger RNA expression of interleukin 1 system members in bovine ovarian follicles and effects of interleukin 1β on primordial follicle activation and survival in vitro.

    PubMed

    Passos, J R S; Costa, J J N; da Cunha, E V; Silva, A W B; Ribeiro, R P; de Souza, G B; Barroso, P A A; Dau, A M P; Saraiva, M V A; Gonçalves, P B D; van den Hurk, R; Silva, J R V

    2016-01-01

    This study aimed to investigate the expression of interleukin 1 (IL-1) system members (proteins and messenger RNA of ligands and receptors) and its distribution in ovarian follicles of cyclic cows and to evaluate the effects of IL-1β on the survival and activation of primordial follicles in vitro. The ovaries were processed for localization of IL-1 system in preantral and antral follicles by immunohistochemical, real-time polymerase chain reaction, and Western blot analysis. For in vitro studies, ovarian fragments were cultured in α-MEM(+) supplemented with IL-1β (0, 1, 10, 50, or 100 ng/mL), and after 6 d, the cultured tissues were processed for histologic analysis. Immunohistochemical results showed that the IL-1 system proteins IL-1β, IL-1RA, IL-1RI, and IL-1RII were detected in the cytoplasm of oocytes and granulosa cells from all follicular categories and theca cells of antral follicles. Variable levels of messenger RNA for the IL-1 system members were observed at different stages of development. After 6 d of culture, the presence of IL-1β (10 or 50 ng/mL) was effective in maintaining the percentage of normal follicles and in promoting primordial follicle activation. In conclusion, IL-1 system members are differentially expressed in ovarian follicles according to their stage of development. Moreover, IL-1β promotes the development of primordial follicles. These results indicate an important role of the IL-1 system in the regulation of bovine folliculogenesis.

  3. Meta-analysis of average symptom change in inpatient treatment for posttraumatic stress disorder in veteran and active duty U.S. military samples.

    PubMed

    Campbell, Justin S; Loeffler, George H; Pulos, Steven; Campbell, Annie W

    2016-11-01

    This study tested the hypothesis that inpatient/residential treatment for PTSD associated with military duty should result in significantly lower PTSD symptoms at patient discharge compared to patient intake. Meta-analysis of effects comparing intake and discharge PTSD symptoms from 26 samples, reported in 16 studies, supported this hypothesis (d = -.73; p < .00001). Moderator analysis indicated between-study variation in PTSD symptom changes was predominantly due to the type of measure used, with the Clinician Administered PTSD Scale producing the largest effect (d = -1.60). Larger effects were also observed for more recently published studies and studies with larger percentages of females. These findings support the efficacy of inpatient treatment for military PTSD, although a causal factor for effectiveness could not be identified. Further, the results indicate between-program comparisons of symptom reduction require the same measure of PTSD. (PsycINFO Database Record

  4. Automobile or other conveyance and adaptive equipment certificate of eligibility for veterans or members of the armed forces with amyotrophic lateral sclerosis. Interim final rule.

    PubMed

    2015-02-25

    The Department of Veterans Affairs (VA) is amending its adjudication regulation regarding certificates of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment. The amendment authorizes automatic issuance of a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment to all veterans with service-connected amyotrophic lateral sclerosis (ALS) and members of the Armed Forces serving on active duty with ALS.

  5. "Secular light curves of 25 members of the themis family of asteroids, suspected of low level cometary activity"

    NASA Astrophysics Data System (ADS)

    Ferrín, Ignacio; Pérez, Martín; Rendón, Juan

    2017-03-01

    From 1996-2015 sixteen main belt asteroids were discovered exhibiting cometary activity (less than one per year), all of them during searches at the telescope. In this work we will explore another way to discover them. We reduced 192.016 magnitude observations of 165 asteroids of the Themis family, using data from the astrometric-photometric database of the Minor Planet Center, MPCOBS, and measuring the absolute magnitudes from the phase plots. 25 objects of 165 (15.2%), exhibited bumps or enhancements in brightness that might indicate low level cometary activity. Since activity repeats at the same place in different orbits and in many occasions is centered at perihelion, activity might be due to water ice sublimation. We do not find support for a correlation between short rotational periods (3-4 h), and cometary activity, although we find an excess of fast rotators.

  6. Pregnancy and Flying Duties

    DTIC Science & Technology

    1994-08-01

    Division U.S. Army Aeromedical Research Laboratory Joy of new life temperamentally unfit to fly and prone to panic in any calamity." In the 1930s, Amelia ...One of my greatest joys has been Earhart said, "Men do not believe us capable." delivering babies for aircrew members and In 1939, women were barred

  7. Call of Duty

    ERIC Educational Resources Information Center

    Shea, Rich

    2007-01-01

    Army National Guard Sergeant James Reynolds is one of about 10,000 former and current military service members who, since 1994, have arrived in the classroom via the federal Troops to Teachers program. Reynolds, who was serving as rear gunner on a Humvee patrolling a Bosnian town, is currently teaching 6th grade students at Hybla Valley…

  8. Hospitalizations for accidents and injuries in the U. S. Navy. I. Duty station assignment and duty status

    SciTech Connect

    Helmkamp, J.C.; Bone, C.M.

    1985-01-01

    The relative incidence of accidental injury hospitalization among Navy enlisted men during the three-year period 1977-1979 was analyzed by duty status (on- or off-duty at the time of injury) for major operational, administrative, tactical, and support activities. Compared to the standard Navy rate, UDT/Seal, Cruiser, Destroyer, and conventionally powered aircraft Carrier personnel had significantly higher total injury hospitalization rates. Nuclear submariners and shore-based personnel had rates significantly lower. When looking at the effects of duty status on injury hospitalization, personnel from Destroyers, Replenishment ships, and conventionally powered Carriers had higher on-duty hospitalization rates, while Nuclear submariners and All other personnel had lower on-duty rates compared to Navywide norms. For off-duty accidents, personnel on Cruisers and Destroyers had significantly higher rates, whereas Fleet Marine Forces and Nuclear submariners had significant correlation observed between on- and off-duty hospitalization rates suggests that common personal attributes such as risk-taking behavior are manifested both on and off the job. Our results have shown that factors associated with the shipboard environment in general, and by ship type specifically, may contribute to the observed high risk of injury. (Author).

  9. hrpL activates Erwinia amylovora hrp gene transcription and is a member of the ECF subfamily of sigma factors.

    PubMed Central

    Wei, Z M; Beer, S V

    1995-01-01

    hrpL of Erwinia amylovora Ea321 encodes a 21.7-kDa regulatory protein, similar to members of the ECF (extra cytoplasmic functions) subfamily of eubacterial RNA polymerase sigma factors. hrpL is a single-gene operon in complementation group VI of the E. amylovora hrp gene cluster. Its product is required by Ea321 to elicit the hypersensitive response (HR) and to cause disease. HrpL controls the expression of five independent hrp loci, including hrpN, which encodes harpin, a proteinaceous elicitor of the HR. hrpL is environmentally regulated, and its expression is affected by hrpS, another regulatory gene of the hrp gene cluster of E. amylovora. pCPP1078, a multicopy plasmid carrying hrpL, is able to restore HR-eliciting ability to hrpS mutants. A conserved motif was identified upstream of the hrpI and hrpN operons, which are transcriptionally regulated by hrpL. This conserved motif shares a high degree of similarity with other biochemically defined or putative ECF-dependent promoter sequences, including sequences upstream of Streptomyces coelicolor dagA P2, Pseudomonas aeruginosa algD, Pseudomonas syringae pv. syringae 61 hrpZ, and P. syringae pv. tomato avrD. In spite of the similarity between the hrpL genes of E. amylovora and P. syringae 61, no functional cross-complementation was observed. PMID:7592386

  10. Conducting an Introductory Biology Course in an Active Learning Classroom: A Case Study of an Experienced Faculty Member

    ERIC Educational Resources Information Center

    Langley, David; Guzey, S. Selcen

    2014-01-01

    A case study is described that examines the beliefs and practices of a university instructor who teaches regularly in an active learning classroom. His perspective provides insights into the pedagogical practices that drive his success in these learning spaces.

  11. Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.

    PubMed

    Yuan, Dongjuan; Lan, Dongming; Xin, Ruipu; Yang, Bo; Wang, Yonghua

    2014-06-12

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1), Penicillium camembertii lipase U-150 (PCL), and Aspergillus oryzae lipase (AOL). Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity.

  12. Structures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily.

    PubMed

    Smith, Paul; Nair, Pravin A; Das, Ushati; Zhu, Hui; Shuman, Stewart

    2011-04-01

    LigD 3'-phosphoesterase (PE) is a component of the bacterial NHEJ apparatus that performs 3'-end-healing reactions at DNA breaks. The tertiary structure, active site and substrate specificity of bacterial PE are unique vis-à-vis other end-healing enzymes. PE homologs are present in archaea, but their properties are uncharted. Here, we demonstrate the end-healing activities of two archaeal PEs--Candidatus Korarchaeum cryptofilum PE (CkoPE; 117 amino acids) and Methanosarcina barkeri PE (MbaPE; 151 amino acids)--and we report their atomic structures at 1.1 and 2.1 Å, respectively. Archaeal PEs are minimized versions of bacterial PE, consisting of an eight-stranded β barrel and a 3(10) helix. Their active sites are located in a crescent-shaped groove on the barrel's outer surface, wherein two histidines and an aspartate coordinate manganese in an octahedral complex that includes two waters and a phosphate anion. The phosphate is in turn coordinated by arginine and histidine side chains. The conservation of active site architecture in bacterial and archaeal PEs, and the concordant effects of active site mutations, underscore a common catalytic mechanism, entailing transition state stabilization by manganese and the phosphate-binding arginine and histidine. Our results fortify the proposal that PEs comprise a DNA repair superfamily distributed widely among taxa.

  13. Structures and Activities of Archaeal Members of the LigD 3-Phosphoesterase DNA Repair Enzyme Superfamily

    SciTech Connect

    P Smith; P Nair; U Das; H Zhu; S Shuman

    2011-12-31

    LigD 3'-phosphoesterase (PE) is a component of the bacterial NHEJ apparatus that performs 3'-end-healing reactions at DNA breaks. The tertiary structure, active site and substrate specificity of bacterial PE are unique vis-a-vis other end-healing enzymes. PE homologs are present in archaea, but their properties are uncharted. Here, we demonstrate the end-healing activities of two archaeal PEs - Candidatus Korarchaeum cryptofilum PE (CkoPE; 117 amino acids) and Methanosarcina barkeri PE (MbaPE; 151 amino acids) - and we report their atomic structures at 1.1 and 2.1 {angstrom}, respectively. Archaeal PEs are minimized versions of bacterial PE, consisting of an eight-stranded {beta} barrel and a 3{sub 10} helix. Their active sites are located in a crescent-shaped groove on the barrel's outer surface, wherein two histidines and an aspartate coordinate manganese in an octahedral complex that includes two waters and a phosphate anion. The phosphate is in turn coordinated by arginine and histidine side chains. The conservation of active site architecture in bacterial and archaeal PEs, and the concordant effects of active site mutations, underscore a common catalytic mechanism, entailing transition state stabilization by manganese and the phosphate-binding arginine and histidine. Our results fortify the proposal that PEs comprise a DNA repair superfamily distributed widely among taxa.

  14. Catalytic activation of OKO zeolite with intersecting pores of 10- and 12-membered rings using atomic layer deposition of aluminium.

    PubMed

    Verheyen, E; Pulinthanathu Sree, S; Thomas, K; Dendooven, J; De Prins, M; Vanbutsele, G; Breynaert, E; Gilson, J-P; Kirschhock, C E A; Detavernier, C; Martens, J A

    2014-05-07

    Tetrahedral framework aluminium was introduced in all-silica zeolite -COK-14 using Atomic Layer Deposition (ALD) involving alternating exposure to trimethylaluminium and water vapour. The modification causes permanent conversion of the originally interrupted framework of -COK-14 to a fully connected OKO type framework, and generates catalytic activity in the acid catalysed hydrocarbon conversion reaction.

  15. Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

    PubMed Central

    Guan, Hongtao; Shuaib, Aban; Leon, David Davila De; Angyal, Adrienn; Salazar, Maria; Velasco, Guillermo; Holcombe, Mike; Dower, Steven K.; Kiss-Toth, Endre

    2016-01-01

    Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for the various binding partners may influence signalling control is currently unclear. We report that tribbles proteins can bind to an overlapping set of MAPK-kinases (MAPKK) in live cells and dictate the localisation of the complexes. Binding studies in transfected cells reveal common regulatory mechanisms and suggest that tribbles and MAPKs may interact with MAPKKs in a competitive manner. Computational modelling of the impact of tribbles on MAPK activation suggests a high sensitivity of this system to changes in tribbles levels, highlighting that these proteins are ideally placed to control the dynamics and balance of activation of concurrent signalling pathways. PMID:27600771

  16. [Patients' rights--doctors' duties].

    PubMed

    Jaeger, L; Bertram, E; Grate, S; Mischkowsky, T; Paul, D; Probst, J; Scala, E; Wbllenweber, H D

    2015-06-01

    On 26 February 2013 the new "Law on Patients' Rights" (hereinafter also the "Law") became effective. This Law strengthens patients' rights vis-à-vis the insurdnce company and also regulates patients' rights regarding their relation to the doctor. This has consequences for the laws on medical liability all doctors must consider. The doctor's performance is and remains a service and such service does not hold any guarantee of success. Nevertheless, this Law primarily reads as a "law on the duties of physicians". To duly take into account these duties and to avoid mistakes and misinterpretation of the Law, the Ethics Committee of the Consortium of Osteosynthesis Trauma Germany (AOTRAUMA-D) has drafted comments on the Law. Brief summaries of its effects are to be found at the end of the respective comment under the heading "Consequences for Practice". The text of the law was influenced particularly by case law, as continuously developed by the German Federal Court of Justice ("BGH"). The implementation of the Law on Patients' Rights was effected by the newly inserted sections 630a to 630h of the German Civil Code (the "BGB"), which are analysed below. The following comments are addressed to physicians only and do not deal with the specific requirements and particularities of the other medical professions such as physiotherapy, midwifery and others so on. Special attention should be paid to the comments on the newly inserted Duty to inform, which has to be fullfilled prior to any diagnostic or therapeutic procedure (sec. 630c para 2 sentence 1 BGB). Under certain conditions the doctor also has to inform the patient about the circumstances that lead to the presumed occurance of a therapeutic or diagnostic malpractice (sec. 630c para. 2 sentence 2 BGB), based on the manifestation of an undesired event or an undesired outcome. As before, the patient's valid consent to any procedure (sec. 630d BGB) is directly linked to the comprehensive and timely provision of information

  17. Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.

    PubMed

    Chen, Hsiao-Huei; Mullett, Steven J; Stewart, Alexandre F R

    2004-07-16

    Cardiac and skeletal muscle genes are regulated by the transcriptional enhancer factor (TEF-1) family of transcription factors. In skeletal muscle, TEF-1 factors interact with a skeletal muscle-specific cofactor called Vestigial-like 2 (Vgl-2) that is related to the Drosophila protein Vestigial. Here, we characterize Vgl-4, the only member of the Vestigial-like family expressed in the heart. Unlike other members of the Vgl family that have a single TEF-1 interaction domain called the tondu (TDU) motif, Vgl-4 has two TDU motifs in its carboxyl-terminal domain. Like other Vgl factors, Vgl-4 physically interacts with TEF-1 in an immunoprecipitation assay. Vgl-4 functionally interacts with TEF-1 and also with myocyte enhancer factor 2 in a mammalian two-hybrid assay. Overexpression of Vgl-4 in cardiac myocytes interfered with the basal expression and alpha1-adrenergic receptor-dependent activation of a TEF-1-dependent skeletal alpha-actin promoter. In cardiac myocytes cultured in serum and in serum-free medium, a myc-tagged Vgl-4 protein was located in the nucleus and cytoplasm but was exported from the nucleus when cells were treated with alpha1-adrenergic receptor agonist. A chimeric nuclear-retained Vgl-4 protein inhibited alpha1-adrenergic receptor-dependent activation. In contrast, deletion of the TDU motifs of Vgl-4 prevented Vgl-4 nuclear localization, relieved Vgl-4 interference of basal activity, and enhanced alpha1-adrenergic up-regulation of the skeletal alpha-actin promoter. Nuclear export of Vgl-4 is dependent on the nuclear exportin CRM-1. These results suggest that Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes.

  18. Is rest after concussion "the best medicine?": recommendations for activity resumption following concussion in athletes, civilians, and military service members.

    PubMed

    Silverberg, Noah D; Iverson, Grant L

    2013-01-01

    Practice guidelines universally recommend an initial period of rest for people who sustain a sports-related concussion or mild traumatic brain injury (MTBI) in daily life or military service. This practice is difficult to reconcile with the compelling evidence that other health conditions can be worsened by inactivity and improved by early mobilization and exercise. We review the scientific basis for the recommendation to rest after MTBI, the challenges and potential unintended negative consequences of implementing it, and how patient management could be improved by refining it. The best available evidence suggests that complete rest exceeding 3 days is probably not helpful, gradual resumption of preinjury activities should begin as soon as tolerated (with the exception of activities that have a high MTBI exposure risk), and supervised exercise may benefit patients with persistent symptoms.

  19. The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60.

    PubMed Central

    Defossez, P A; Baert, J L; Monnot, M; de Launoit, Y

    1997-01-01

    Transcription factors are modular entities built up of discrete domains, some devoted to DNA binding and others permitting transcriptional modulation. The structure of DNA binding domains has been thoroughly investigated and structural classes clearly defined. In sharp contrast, the structural constraints put on transactivating regions, if any, are mostly unknown. Our investigations focus on ERM, a eukaryotic transcription factor of the ETS family. We have previously shown that ERM harbours two transactivating domains (TADs) with distinct functional features: AD1 lies in the first 72 amino acids of ERM, while AD2 sits in the last 62. Here we show that AD1 is a bona fide acidic TAD, for it activated transcription in yeast cells, while AD2 did not. AD1 contains a 20 amino acid stretch predicted to form an alpha-helix that is found unchanged in the related PEA3 and ER81 transcription factors. Circular dichroism analysis revealed that a 32 amino acid peptide encompassing this region is unstructured in water but folds into a helix when the hydrophobic solvent trifluoroethanol is added. The isolated helix was sufficient to activate transcription and mutations predicted to disrupt it dramatically affected AD1-driven transactivation, whereas mutations decreasing its acidity had more gentle effects. A phenylalanine residue within the helix was particularly sensitive to mutations. Finally, we observed that ERM bound TAFII60 via AD1 and bound TBP and TAFII40, presumably via other activation domains. PMID:9358152

  20. [Physician Counseling about Physical and Sports Activity in Neurological Practices in Germany: Results of a Survey Among Members of the German Neurological Society].

    PubMed

    Reimers, C D; Reuter, I; Straube, A; Tettenborn, B; Braumann, K M; Reimers, A K

    2016-01-01

    Physical inactivity is a major but modifiable risk factor for morbidity and mortality. Regular physical activity has preventive and therapeutic effects on numerous diseases including neurological disorders. Therefore, it is desirable that physicians motivate their patients to increase their physical and sports activities and that they help them to overcome barriers to exercising. The present study is a survey of neurologists who are members of the German Neurological Society with their own practices; they were asked whether they advised their patients on the benefits of physical activity. Details on physician counseling on physical activity were obtained, such as the frequency of counseling, the neurological disorders considered by the practitioners to be worth the effort of counseling, and the barriers to exercise on the part of patients. More than 80 % of the participants who responded to the survey stated that they frequently provide their patients with advice on the preventive and therapeutic aspects of physical activity. Almost all of them recommended endurance sports; this was followed by Far Eastern types of sport such as tai chi or yoga (70 % of all physicians who advice sports activities). The frequency of counseling about physical activity significantly correlated to the physician's own sports activity. Frequency of counseling was reduced if the physician assessed the patients to be incapable of adopting and maintaining a lifestyle of habitual physical activity. Lack of time as well as an insufficient reimbursement of the counseling, however, did not significantly influence the frequency of counseling. The physician's own sports activity matched that of individuals with similar social status. Thus, a selection bias does not seem to be of importance regarding the results of the survey. However, since only 169 of the 784 invited neurologists (21.6 %) responded to the questionnaire, the representativeness of the survey may be limited. Counseling about

  1. Partners' attributions for service members' symptoms of combat-related posttraumatic stress disorder.

    PubMed

    Renshaw, Keith D; Allen, Elizabeth S; Carter, Sarah P; Markman, Howard J; Stanley, Scott M

    2014-03-01

    The association of service members' combat-related PTSD with partners' distress is weaker when spouses/partners believe that service members experienced more traumatic events during deployment. Also, when simultaneously examining partners' perceptions of all PTSD symptoms, perceptions of reexperiencing symptoms (the symptoms most obviously connected to traumatic events) are significantly negatively related to distress in partners. These findings are consistent with the notion that partners may be less distressed if they make external, rather than internal, attributions for service members' symptoms. The present study explicitly tests this possibility. Civilian wives of active duty service members completed measures regarding their own marital satisfaction, their perceptions of service members' combat exposure during deployments, their perceptions of service members' symptoms of PTSD, and their attributions for those symptoms. External attributions were significantly positively associated with perceptions of combat exposure (rp=.31) and reexperiencing symptoms (β=.33) and significantly negatively associated with perceptions of numbing/withdrawal symptoms (rp=-.22). In contrast, internal attributions were significantly negatively associated with perceptions of reexperiencing symptoms (β=-.18) and significantly positively associated with perceptions of numbing/withdrawal symptoms (β=.46). Internal attributions significantly moderated the negative association of PTSD symptoms with marital satisfaction, such that the association strengthened as internal attributions increased. These findings are the first explicit support for an attributional understanding of distress in partners of combat veterans. Interventions that alter partners' attributions may improve marital functioning.

  2. The impact of multiple concussions on emotional distress, post-concussive symptoms, and neurocognitive functioning in active duty United States marines independent of combat exposure or emotional distress.

    PubMed

    Spira, James L; Lathan, Corinna E; Bleiberg, Joseph; Tsao, Jack W

    2014-11-15

    Controversy exists as to whether the lingering effects of concussion on emotional, physical, and cognitive symptoms is because of the effects of brain trauma or purely to emotional factors such as post-traumatic stress disorder or depression. This study examines the independent effects of concussion on persistent symptoms. The Defense Automated Neurobehavioral Assessment, a clinical decision support tool, was used to assess neurobehavioral functioning in 646 United States Marines, all of whom were fit for duty. Marines were assessed for concussion history, post-concussive symptoms, emotional distress, neurocognitive functioning, and deployment history. Results showed that a recent concussion or ever having experienced a concussion was associated with an increase in emotional distress, but not with persistent post-concussive symptoms (PPCS) or neurocognitive functioning. Having had multiple lifetime concussions, however, was associated with greater emotional distress, PPCS, and reduced neurocognitive functioning that needs attention and rapid discrimination, but not for memory-based tasks. These results are independent of deployment history, combat exposure, and symptoms of post-traumatic stress disorder and depression. Results supported earlier findings that a previous concussion is not generally associated with post-concussive symptoms independent of covariates. In contrast with other studies that failed to find a unique contribution for concussion to PPCS, however, evidence of recent and multiple concussion was seen across a range of emotional distress, post-concussive symptoms, and neurocognitive functioning in this study population. Results are discussed in terms of implications for assessing concussion on return from combat.

  3. Associations between sleep difficulties and risk factors for cardiovascular disease in veterans and active duty military personnel of the Iraq and Afghanistan conflicts.

    PubMed

    Ulmer, Christi S; Bosworth, Hayden B; Germain, Anne; Lindquist, Jennifer; Olsen, Maren; Brancu, Mira; Beckham, Jean C

    2015-06-01

    Recent evidence suggests that sleep disturbance may play an important role in the development of cardiovascular disease (CVD). Despite the prevalence of sleep complaints among service members of recent military conflicts, few studies have examined associations between sleep and risk factors for CVD in this population. Symptom checklist items regarding distress about "trouble falling asleep" and "restless/disturbed sleep" were used as proxies for sleep onset and maintenance difficulties to examine these associations in US military service members of recent conflicts. Veterans having both sleep onset and maintenance difficulties had greater odds of being a current smoker and having psychiatric symptoms and diagnoses. Increased odds of a self-reported hypertension diagnosis and elevated systolic blood pressure were also found in certain subsets of this sample. Findings highlight the need for greater recognition of sleep difficulties as a CVD risk factor in a population known to be at increased risk for this condition.

  4. Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems: VapBC-5 from Mycobacterium tuberculosis

    SciTech Connect

    Miallau, L.; Faller, M.; Chiang, J.; Arbing, M.; Guo, F.; Cascio, D.; Eisenberg, D.

    2009-03-02

    In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapBC family of complexes from M. tuberculosis. The toxin VapC-5 is a compact, 150 residues, two domain {alpha}/{beta} protein. Bent around the toxin is the VapB-5 antitoxin, a 33-residue {alpha}-helix. Assays suggest that the toxin is an Mg-enabled endoribonuclease, inhibited by the antitoxin. The lack of DNase activity is consistent with earlier suggestions that the complex represses its own operon. Furthermore, analysis of the interactions in the binding of the antitoxin to the toxin suggest that exquisite control is required to protect the bacteria cell from toxic VapC-5.

  5. Mineralocorticoid Receptor (MR) trans-Activation of Inflammatory AP-1 Signaling: DEPENDENCE ON DNA SEQUENCE, MR CONFORMATION, AND AP-1 FAMILY MEMBER EXPRESSION.

    PubMed

    Dougherty, Edward J; Elinoff, Jason M; Ferreyra, Gabriela A; Hou, Angela; Cai, Rongman; Sun, Junfeng; Blaine, Kevin P; Wang, Shuibang; Danner, Robert L

    2016-11-04

    Glucocorticoids are commonly used to treat inflammatory disorders. The glucocorticoid receptor (GR) can tether to inflammatory transcription factor complexes, such as NFκB and AP-1, and trans-repress the transcription of cytokines, chemokines, and adhesion molecules. In contrast, aldosterone and the mineralocorticoid receptor (MR) primarily promote cardiovascular inflammation by incompletely understood mechanisms. Although MR has been shown to weakly repress NFκB, its role in modulating AP-1 has not been established. Here, the effects of GR and MR on NFκB and AP-1 signaling were directly compared using a variety of ligands, two different AP-1 consensus sequences, GR and MR DNA-binding domain mutants, and siRNA knockdown or overexpression of core AP-1 family members. Both GR and MR repressed an NFκB reporter without influencing p65 or p50 binding to DNA. Likewise, neither GR nor MR affected AP-1 binding, but repression or activation of AP-1 reporters occurred in a ligand-, AP-1 consensus sequence-, and AP-1 family member-specific manner. Notably, aldosterone interactions with both GR and MR demonstrated a potential to activate AP-1. DNA-binding domain mutations that eliminated the ability of GR and MR to cis-activate a hormone response element-driven reporter variably affected the strength and polarity of these responses. Importantly, MR modulation of NFκB and AP-1 signaling was consistent with a trans-mechanism, and AP-1 effects were confirmed for specific gene targets in primary human cells. Steroid nuclear receptor trans-effects on inflammatory signaling are context-dependent and influenced by nuclear receptor conformation, DNA sequence, and the expression of heterologous binding partners. Aldosterone activation of AP-1 may contribute to its proinflammatory effects in the vasculature.

  6. Quiescin Sulfhydryl Oxidase from Trypanosoma brucei: Catalytic Activity and Mechanism of a QSOX Family Member with a Single Thioredoxin Domain†

    PubMed Central

    Kodali, Vamsi K.; Thorpe, Colin

    2010-01-01

    Quiescin-sulfhydryl oxidase (QSOX) flavoenzymes catalyze the direct, facile, insertion of disulfide bonds into reduced unfolded proteins with the reduction of oxygen to hydrogen peroxide. To date, only QSOXs from vertebrates have been characterized enzymatically. These metazoan sulfhydryl oxidases have 4 recognizable domains: a redox-active thioredoxin (Trx) domain containing the first of three CxxC motifs (CI-CII), a second Trx domain with no obvious redox-active disulfide, a helix-rich domain, and then an Erv/ALR domain. This last domain contains the FAD moiety, a proximal CIII-CIV disulfide and a third CxxC of unknown function (CV-CVI). Plant and protist QSOXs lack the second Trx domain, but otherwise appear to contain the same complement of redox centers. This work presents the first characterization of a single-Trx QSOX. Trypanosoma brucei QSOX was expressed in Escherichia coli using a synthetic gene and found to be a stable, monomeric, FAD-containing protein. Although evidently lacking an entire domain, TbQSOX shows catalytic activity and substrate specificity similar to the vertebrate QSOXs examined previously. Unfolded reduced proteins are more than 200-fold more effective substrates on a per-thiol basis than glutathione, and some 10-fold better than the parasite bis-glutathione analog, trypanothione. These data are consistent with a role for the protist QSOX in oxidative protein folding. Site-directed mutagenesis of each of the 6 cysteine residues (to serines) show that the CxxC motif in the single Trx domain is crucial for efficient catalysis of the oxidation of both reduced RNase and the model substrate dithiothreitol. As expected, the proximal disulfide CIII-CIV, which interacts with the flavin, is catalytically crucial. However, as observed with human QSOX1, the third CxxC motif shows no obvious catalytic role during the in vitro oxidation of reduced RNase or dithiothreitol. Pre-steady state kinetics demonstrates that turnover in TbQSOX is limited by

  7. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity.

    PubMed

    Vestal, Deborah J

    2005-08-01

    The guanylate-binding proteins (GBPs) were first identified in the late 1970s, and within a short period of time, investigators were aware that GBPs possessed unique properties, in particular the ability to bind GMP agarose. Since then, much study has gone into understanding their mechanism of induction by interferons (IFNs) and other cytokines, and they have been used extensively as markers for IFN responsiveness in both cells and organisms. In time, we learned that GBPs had the unusual ability to hydrolyze GTP to both GDP and GMP. More recently, we have begun to appreciate their novel structure, one that suggests unique mechanisms of GTP binding and hydrolysis and unique forms of regulation. In addition, we have begun to unravel some of their functions and to separate these function into those functions that do and those that do not require GTPase activity.

  8. Episodic ataxia type 2 manifests as epileptiform electroencephalographic activity with no epileptic attacks in two family members.

    PubMed

    Kaido, Misako; Furuta, Mitsuru; Nakamori, Masayuki; Yuasa, Yoshihito; Takahashi, Masanori P

    2016-04-28

    Here, we report two cases of episodic ataxia type 2 (EA2) in a 63-year-old woman and her 36-year-old daughter. The mother experienced recurrent attacks of cerebellar dysfunction lasting 4 to 5 hours since the age of 41 years. On several occasions, she was admitted to the emergency room, where she was diagnosed with epilepsy or stroke. Based on these diagnoses, she was treated with antiepileptic or anticoagulant drugs, but both treatments were eventually discontinued. The frequency of the attacks increased after the patient reached the age of 62. Interictal neurological examination demonstrated signs of slight cerebellar ataxia, i.e. saccadic eye movements, gaze-directed nystagmus, and mild truncal ataxia. Brain magnetic resonance imaging (MRI) showed cerebellar vermis atrophy. Electroencephalography (EEG) revealed various spike and wave patterns: solitary spikes, spike-and-slow wave complexes, and slow wave bursts. Photoparoxysmal response (PPR) type 3 was also observed. Treatment with acetazolamide abolished the patient's attacks almost completely. The daughter started experiencing 5- to 10-minute ataxic episodes at the age of 16 years. Based on her epileptiform EEG activities with PPR (type 2), antiepileptic drugs (valproate and zonisamide) were prescribed. Despite pharmacological treatment, the attacks recurred; however, their frequency gradually decreased with time, until they almost entirely disappeared when the patient was 33. Unfortunately, migraine-like headaches arose instead. Subtle truncal ataxia was observed during interictal periods. Sanger sequencing of the exons of the CACNA1A gene revealed a novel single base deletion (c.3575delA) in both patients. Despite the difference in age of onset and clinical course, both patients showed clearly epileptiform EEG activities without experiencing the concurrent epileptic episodes. Thus, EA2 is a disease that may be misdiagnosed as epilepsy or stroke in the field of emergency medicine.

  9. Glutathione S-transferase (GST) family in barley: identification of members, enzyme activity, and gene expression pattern.

    PubMed

    Rezaei, Mohammad Kazem; Shobbar, Zahra-Sadat; Shahbazi, Maryam; Abedini, Raha; Zare, Sajjad

    2013-09-15

    Barley (Hordeum vulgare) is one of the most important cereals in many developing countries where drought stress considerably diminishes agricultural production. Glutathione S-transferases (GSTs EC 2.5.1.18) are multifunctional enzymes which play a crucial role in cellular detoxification and oxidative stress tolerance. In this study, 84 GST genes were identified in barley by a comprehensive in silico approach. Sequence alignment and phylogenetic analysis grouped these HvGST proteins in eight classes. The largest numbers of the HvGST genes (50) were included in the Tau class followed by 21 genes in Phi, five in Zeta, two in DHAR, two in EF1G, two in Lambda, and one each in TCHQD and Theta classes. Phylogenetic analysis of the putative GSTs from Arabidopsis, rice, and barley indicated that major functional diversification within the GST family predated the monocot/dicot divergence. However, intra-specious duplication seems to be common. Expression patterns of five GST genes from Phi and Tau classes were investigated in three barley genotypes (Yusof [drought-tolerant], Moroc9-75 [drought-sensitive], and HS1 [wild ecotype]) under control and drought-stressed conditions, during the vegetative stage. All investigated genes were up-regulated significantly under drought stress and/or showed a higher level of transcripts in the tolerant cultivar. Additionally, GST enzyme activity was superior in Yusof and induced in the extreme-drought-treated leaves, while it was not changed in Moroc9-75 under drought conditions. Moreover, the lowest and highest levels of lipid peroxidation were observed in the Yusof and Moroc9-75 cultivars, respectively. Based on the achieved results, detoxification and antioxidant activity of GSTs might be considered an important factor in the drought tolerance of barley genotypes for further investigations.

  10. MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10.

    PubMed

    Lin, Jibin; He, Shaolin; Sun, Xinghui; Franck, Gregory; Deng, Yihuan; Yang, Dafeng; Haemmig, Stefan; Wara, A K M; Icli, Basak; Li, Dazhu; Feinberg, Mark W

    2016-09-01

    Thrombogenic and inflammatory mediators, such as thrombin, induce NF-κB-mediated endothelial cell (EC) activation and dysfunction, which contribute to pathogenesis of arterial thrombosis. The role of anti-inflammatory microRNA-181b (miR-181b) on thrombosis remains unknown. Our previous study demonstrated that miR-181b inhibits downstream NF-κB signaling in response to TNF-α. Here, we demonstrate that miR-181b uniquely inhibits upstream NF-κB signaling in response to thrombin. Overexpression of miR-181b inhibited thrombin-induced activation of NF-κB signaling, demonstrated by reduction of phospho-IKK-β, -IκB-α, and p65 nuclear translocation in ECs. MiR-181b also reduced expression of NF-κB target genes VCAM-1, intercellular adhesion molecule-1, E-selectin, and tissue factor. Mechanistically, miR-181b targets caspase recruitment domain family member 10 (Card10), an adaptor protein that participates in activation of the IKK complex in response to signals transduced from protease-activated receptor-1. miR-181b reduced expression of Card10 mRNA and protein, but not protease-activated receptor-1. 3'-Untranslated region reporter assays, argonaute-2 microribonucleoprotein immunoprecipitation studies, and Card10 rescue studies revealed that Card10 is a bona fide direct miR-181b target. Small interfering RNA-mediated knockdown of Card10 expression phenocopied effects of miR-181b on NF-κB signaling and targets. Card10 deficiency did not affect TNF-α-induced activation of NF-κB signaling, which suggested stimulus-specific regulation of NF-κB signaling and endothelial responses by miR-181b in ECs. Finally, in response to photochemical injury-induced arterial thrombosis, systemic delivery of miR-181b reduced thrombus formation by 73% in carotid arteries and prolonged time to occlusion by 1.6-fold, effects recapitulated by Card10 small interfering RNA. These data demonstrate that miR-181b and Card10 are important regulators of thrombin-induced EC activation and

  11. Repression of Androgen Receptor Activity by HEYL, a Third Member of the Hairy/Enhancer-of-split-related Family of Notch Effectors*

    PubMed Central

    Lavery, Derek N.; Villaronga, M. Angeles; Walker, Marjorie M.; Patel, Anup; Belandia, Borja; Bevan, Charlotte L.

    2011-01-01

    The Hairy/Enhancer-of-split-related with YRPW-like motif (HEY) family of proteins are transcriptional repressors and downstream effectors of Notch signaling. We previously reported that HEY1 and HEY2 selectively repress androgen receptor (AR) signaling in mammalian cell lines and have shown that in human tissue HEY1 is excluded from the nuclei in prostate cancer but not benign prostatic hyperplasia. We have now characterized a third member of this family, HEYL, which is a more potent repressor of AR activity. HEYL interacted with and repressed AR activation function-1 domain and competitively inhibited SRC1e activation of AR transcriptional activity. Using a cell line inducibly expressing exogenous HEYL, we showed that HEYL represses endogenous AR-regulated genes and reduces androgen-dependent prostate cancer cell growth. Using a trans-repression assay, we identified both trichostatin-sensitive and -insensitive domains within HEYL; however, analysis of endogenous AR target genes suggested that HEYL represses AR activity through histone deacetylase I/II-independent mechanisms. Immunohistochemical analyses of tissue indicated that, in a fashion similar to that previously reported for HEY1, HEYL is excluded from the nuclei in prostate cancer but not adjacent benign tissue. This suggests that nuclear exclusion of HEY proteins may be an important step in the progression of prostate cancer. PMID:21454491

  12. A novel active fire protection approach for structural steel members using NiTi shape memory alloy

    NASA Astrophysics Data System (ADS)

    Sadiq, H.; Wong, M. B.; Al-Mahaidi, R.; Zhao, X. L.

    2013-02-01

    A novel active fire protection approach, based on integrating a shape memory alloy, NiTi, with a steel structure, was proposed to satisfy the fire resistance requirements in structural design. To demonstrate the principles of this approach, a simple structure in the form of a simply supported steel beam was used. The internal action of the beam due to a transverse applied load was reduced by utilizing the shape memory effect in the NiTi alloy at rising temperatures. As a result, the net internal action from the load design was kept below the deteriorated load capacity of the beam during the fire scenario for period of time that was longer than that of the original beam without the NiTi alloy. By integrating the NiTi alloy into the beam system, the structure remained stable even though the steel temperature exceeded the critical temperature which may have caused the original beam structure to collapse. Prior to testing the composite NiTi-steel beam under simulated fire conditions, the NiTi alloy specimens were characterized at high temperatures. At 300 °C, the stiffness of the specimens increased by three times and its strength by four times over that at room temperature. The results obtained from the high-temperature characterization highlighted the great potential of the alloy being used in fire engineering applications.

  13. The Human SWI-SNF Complex Protein p270 Is an ARID Family Member with Non-Sequence-Specific DNA Binding Activity

    PubMed Central

    Dallas, Peter B.; Pacchione, Stephen; Wilsker, Deborah; Bowrin, Valerie; Kobayashi, Ryuji; Moran, Elizabeth

    2000-01-01

    p270 is an integral member of human SWI-SNF complexes, first identified through its shared antigenic specificity with p300 and CREB binding protein. The deduced amino acid sequence of p270 reported here indicates that it is a member of an evolutionarily conserved family of proteins distinguished by the presence of a DNA binding motif termed ARID (AT-rich interactive domain). The ARID consensus and other structural features are common to both p270 and yeast SWI1, suggesting that p270 is a human counterpart of SWI1. The approximately 100-residue ARID sequence is present in a series of proteins strongly implicated in the regulation of cell growth, development, and tissue-specific gene expression. Although about a dozen ARID proteins can be identified from database searches, to date, only Bright (a regulator of B-cell-specific gene expression), dead ringer (a Drosophila melanogaster gene product required for normal development), and MRF-2 (which represses expression from the cytomegalovirus enhancer) have been analyzed directly in regard to their DNA binding properties. Each binds preferentially to AT-rich sites. In contrast, p270 shows no sequence preference in its DNA binding activity, thereby demonstrating that AT-rich binding is not an intrinsic property of ARID domains and that ARID family proteins may be involved in a wider range of DNA interactions. PMID:10757798

  14. Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G

    PubMed Central

    Kakkar, Vaishali; Kuiper, E. F. Elsiena; Pandey, Abhinav; Braakman, Ineke; Kampinga, Harm H.

    2016-01-01

    Parkinson’s disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the disease. A loss of function parkin RING1 domain mutant (C289G) is associated with autosomal-recessive juvenile-onset Parkinsonism (AR-JP) and displays altered solubility and sequesters into aggregates. Single overexpression of almost each individual member of the Hsp40 (DNAJ) family of chaperones efficiently reduces parkin C289G aggregation and requires interaction with and activity of endogenously expressed Hsp70 s. For DNAJB6 and DNAJB8, potent suppressors of aggregation of polyglutamine proteins for which they rely mainly on an S/T-rich region, it was found that the S/T-rich region was dispensable for suppression of parkin C289G aggregation. Our data implies that different disease-causing proteins pose different challenges to the protein homeostasis system and that DNAJB6 and DNAJB8 are highly versatile members of the DNAJ protein family with multiple partially non-overlapping modes of action with respect to handling disease-causing proteins, making them interesting potential therapeutic targets. PMID:27713507

  15. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection...

  16. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection...

  17. The impact of attachment style on posttraumatic stress disorder symptoms in postdeployed service members.

    PubMed

    Escolas, Sandra M; Arata-Maiers, Rachel; Hildebrandt, Erika J; Maiers, Alan J; Mason, Shawn T; Baker, Monty T

    2012-01-01

    This study examined the effects of attachment style on self-reported posttraumatic stress disorder (PTSD) symptoms in a population of service members (N=561). Active duty, postdeployment service members completed anonymous questionnaires including 2 measures of adult attachment and the PTSD checklist-military as a measure of PTSD symptoms. Results confirmed the central hypothesis that attachment style was related to reported PTSD symptoms. Secure attachment style was associated with less reported PTSD symptoms and therefore may be involved in mechanisms associated with protection from developing PTSD after experiencing wartime trauma. Results were consistent when tested across continuous and dichotomous assessments that captured diagnostic criteria. This study demonstrates a significant relationship between attachment style and PTSD symptoms within a military population, potentially providing the basis for future research in this area.

  18. Understanding Air Force members' intentions to participate in pro-environmental behaviors: an application of the theory of planned behavior.

    PubMed

    Laudenslager, Mark S; Lofgren, Steven T; Holt, Daniel T

    2004-06-01

    At a single installation, a cross section of 307 active duty Air Force members completed questionnaires to assess whether the theory of planned behavior was useful in explaining the service members' intentions to participate in three environmentally protective behaviors-recycling, carpooling, and energy conservation. While the individual tenets of the theory of planned behavior, i.e., attitude toward the behavior, subjective norms, and perceived control, accounted for differing amounts of variance in intentions, the results indicated that the intentions of these Air Force members to recycle, conserve energy, and carpool were moderately explained by the tenets of the theory of planned behavior collectively when the results of a multiple regression were analyzed.

  19. Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs.

    PubMed

    Leskinen, Tuija; Rinnankoski-Tuikka, Rita; Rintala, Mirva; Seppänen-Laakso, Tuulikki; Pöllänen, Eija; Alen, Markku; Sipilä, Sarianna; Kaprio, Jaakko; Kovanen, Vuokko; Rahkila, Paavo; Oresic, Matej; Kainulainen, Heikki; Kujala, Urho M

    2010-09-16

    High physical activity/aerobic fitness predicts low morbidity and mortality. Our aim was to identify the most up-regulated gene sets related to long-term physical activity vs. inactivity in skeletal muscle and adipose tissues and to obtain further information about their link with cardio-metabolic risk factors. We studied ten same-sex twin pairs (age range 50-74 years) who had been discordant for leisure-time physical activity for 30 years. The examinations included biopsies from m. vastus lateralis and abdominal subcutaneous adipose tissue. RNA was analyzed with the genome-wide Illumina Human WG-6 v3.0 Expression BeadChip. For pathway analysis we used Gene Set Enrichment Analysis utilizing active vs. inactive co-twin gene expression ratios. Our findings showed that among the physically active members of twin pairs, as compared to their inactive co-twins, gene expression in the muscle tissue samples was chronically up-regulated for the central pathways related to energy metabolism, including oxidative phosphorylation, lipid metabolism and supportive metabolic pathways. Up-regulation of these pathways was associated in particular with aerobic fitness and high HDL cholesterol levels. In fat tissue we found physical activity-associated increases in the expression of polyunsaturated fatty acid metabolism and branched-chain amino acid degradation gene sets both of which associated with decreased 'high-risk' ectopic body fat and plasma glucose levels. Consistent with other findings, plasma lipidomics analysis showed up-regulation of the triacylglycerols containing the polyunsaturated fatty acids. Our findings identified skeletal muscle and fat tissue pathways which are associated with the long-term physical activity and reduced cardio-metabolic disease risk, including increased aerobic fitness. In particular, improved skeletal muscle oxidative energy and lipid metabolism as well as changes in adipocyte function and redistribution of body fat are associated with reduced

  20. Light Duty Efficient, Clean Combustion

    SciTech Connect

    Stanton, Donald W.

    2011-06-03

    Cummins has successfully completed the Light Duty Efficient Clean Combustion (LDECC) cooperative program with DoE. This program was established in 2007 in support of the Department of Energy’s Vehicles Technologies Advanced Combustion and Emissions Control initiative to remove critical barriers to the commercialization of advanced, high efficiency, emissions compliant internal combustion (IC) engines for light duty vehicles. Work in this area expanded the fundamental knowledge of engine combustion to new regimes and advanced the knowledge of fuel requirements for these diesel engines to realize their full potential. All of our objectives were met with fuel efficiency improvement targets exceeded.

  1. A multisite study of the relationships between blast exposures and symptom reporting in a post-deployment active duty military population with mild traumatic brain injury.

    PubMed

    Reid, Matthew W; Miller, Kelly J; Lange, Rael T; Cooper, Douglas B; Tate, David F; Bailie, Jason; Brickell, Tracey A; French, Louis M; Asmussen, Sarah; Kennedy, Jan E

    2014-12-01

    Explosive devices have been the most frequent cause of traumatic brain injury (TBI) among deployed contemporary U.S. service members. The purpose of this study was to examine the influence of previous cumulative blast exposures (that did or did not result in TBI) on later post-concussion and post-traumatic symptom reporting after sustaining a mild TBI (MTBI). Participants were 573 service members who sustained MTBI divided into four groups by number of blast exposures (1, 2, 3, and 4-10) and a nonblast control group. Post-concussion symptoms were measured using the Neurobehavioral Symptom Inventory (NSI) and post-traumatic stress disorder (PTSD) symptoms using the Post-traumatic Checklist-Civilian version (PCL-C). Results show groups significantly differed on total NSI scores (p<0.001), where symptom endorsement increased as number of reported blast exposures increased. Total NSI scores were significantly higher for the 3- and 4-10 blast groups compared with the 1- and 2-blast groups with effect sizes ranging from small to moderate (d=0.31 to 0.63). After controlling for PTSD symptoms using the PCL-C total score, NSI total score differences remained between the 4-10-blast group and the 1- and 2-blast groups, but were less pronounced (d=0.35 and d=0.24, respectively). Analyses of NSI subscale scores using PCL-C scores as a covariate revealed significant between-blast group differences on cognitive, sensory, and somatic, but not affective symptoms. Regression analyses revealed that cumulative blast exposures accounted for a small but significant amount of the variance in total NSI scores (4.8%; p=0.009) and total PCL-C scores (2.3%; p<0.001). Among service members exposed to blast, post-concussion symptom reporting increased as a function of cumulative blast exposures. Future research will need to determine the relationship between cumulative blast exposures, symptom reporting, and neuropathological changes.

  2. A Multisite Study of the Relationships between Blast Exposures and Symptom Reporting in a Post-Deployment Active Duty Military Population with Mild Traumatic Brain Injury

    PubMed Central

    Miller, Kelly J.; Lange, Rael T.; Cooper, Douglas B.; Tate, David F.; Bailie, Jason; Brickell, Tracey A.; French, Louis M.; Asmussen, Sarah; Kennedy, Jan E.

    2014-01-01

    Abstract Explosive devices have been the most frequent cause of traumatic brain injury (TBI) among deployed contemporary U.S. service members. The purpose of this study was to examine the influence of previous cumulative blast exposures (that did or did not result in TBI) on later post-concussion and post-traumatic symptom reporting after sustaining a mild TBI (MTBI). Participants were 573 service members who sustained MTBI divided into four groups by number of blast exposures (1, 2, 3, and 4–10) and a nonblast control group. Post-concussion symptoms were measured using the Neurobehavioral Symptom Inventory (NSI) and post-traumatic stress disorder (PTSD) symptoms using the Post-traumatic Checklist-Civilian version (PCL-C). Results show groups significantly differed on total NSI scores (p<0.001), where symptom endorsement increased as number of reported blast exposures increased. Total NSI scores were significantly higher for the 3– and 4–10 blast groups compared with the 1- and 2-blast groups with effect sizes ranging from small to moderate (d=0.31 to 0.63). After controlling for PTSD symptoms using the PCL-C total score, NSI total score differences remained between the 4–10-blast group and the 1- and 2-blast groups, but were less pronounced (d=0.35 and d=0.24, respectively). Analyses of NSI subscale scores using PCL-C scores as a covariate revealed significant between-blast group differences on cognitive, sensory, and somatic, but not affective symptoms. Regression analyses revealed that cumulative blast exposures accounted for a small but significant amount of the variance in total NSI scores (4.8%; p=0.009) and total PCL-C scores (2.3%; p<0.001). Among service members exposed to blast, post-concussion symptom reporting increased as a function of cumulative blast exposures. Future research will need to determine the relationship between cumulative blast exposures, symptom reporting, and neuropathological changes. PMID:25036531

  3. Phosphorylation of a member of the MBF1 transcriptional co-activator family, StMBF1, is stimulated in potato cell suspensions upon fungal elicitor challenge.

    PubMed

    Zanetti, María Eugenia; Blanco, Flavio Antonio; Daleo, Gustavo Raúl; Casalongué, Claudia Anahí

    2003-02-01

    StMBF1 (Solanum tuberosum multiprotein bridging factor 1) is a plant member of the MBF1 family of transcriptional co-activators. Previously, it has been described as being up-regulated at the transcriptional level by fungal and abiotic stress. To understand whether StMBF1 is also regulated at the post-translational level, in vitro as well as in vivo phosphorylation assays were performed. StMBF1 is phosphorylated under both experimental conditions and [(32)P] incorporation into StMBF1 increases after treatment of potato cells with hyphal cell wall components (HWC) derived from Phytophthora infestans. The StMBF1-phosphorylating activity is strongly inhibited by the calcium-chelator EGTA and partially inhibited by calmodulin antagonists. Using bacterial purified StMBF1 as a substrate, a 57 kDa calcium-dependent protein kinase (p57) that is able to phosphorylate StMBF1 was detected. The StMBF1 kinase activity of p57 was higher in elicited than in non-treated cells. The role of the elicitor-dependent phosphorylation of StMBF1 is discussed.

  4. Triggering of human monocyte activation through CD69, a member of the natural killer cell gene complex family of signal transducing receptors

    PubMed Central

    1994-01-01

    The expression and function of CD69, a member of the natural killer cell gene complex family of signal transducing receptors, was investigated on human monocytes. CD69 was found expressed on all peripheral blood monocytes, as a 28- and 32-kD disulfide-linked dimer. Molecular cross-linking of CD69 receptors induced extracellular Ca2+ influx, as revealed by flow cytometry. CD69 cross-linking resulted also in phospholipase A2 activation, as detected by in vivo arachidonic acid release measurement from intact cells and by direct in vitro measurement of enzymatic activity using radiolabeled phosphatidylcholine vesicles. Prostaglandin E 2 alpha, 6-keto- prostaglandin F 1 alpha, and leukotriene B4 were detected by radioimmunoassay in supernatants from CD69-stimulated monocytes, suggesting the activation of both cyclooxygenase and lipoxygenase pathways after CD69 stimulation. CD69 cross-linking, moreover, was able to induce strong nitric oxide (NO) production from monocytes, as detected by accumulation of NO oxydixed derivatives, and cyclic GMP. It is important to note that NO generation was responsible for CD69- mediated increase in spontaneous cytotoxicity against L929 murine transformed fibroblast cell line and induction of redirected cytotoxicity towards P815 FcRII+ murine mastocytoma cell line. These data indicate that CD69 can act as a potent stimulatory molecule on the surface of human peripheral blood monocytes. PMID:7964477

  5. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could ...

  6. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evidence supports the theory that the bacterial communities colonizing E. purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be a...

  7. Electricity Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This task list is intended for use in planning and/or evaluating a competency-based course in electricity. The guide outlines the tasks entailed in 10 different duties typically required of employees in the following occupations: residential electrician apprentice, material handler/supply clerk, maintenance electrician apprentice,…

  8. Synthesis, characterization and in vitro anticancer activity of 18-membered octaazamacrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II)

    NASA Astrophysics Data System (ADS)

    Kareem, Abdul; Zafar, Hina; Sherwani, Asif; Mohammad, Owais; Khan, Tahir Ali

    2014-10-01

    An effective series of 18 membered octaazamacrocyclic complexes of the type [MLX2], where X = Cl or NO3 have been synthesized by template condensation reaction of oxalyl dihydrazide with dibenzoylmethane and metal salt in 2:2:1 molar ratio. The formation of macrocyclic framework, stereochemistry and their overall geometry have been characterized by various physico-chemical studies viz., elemental analysis, electron spray ionization-mass spectrometry (ESI-MS), I.R, UV-Vis, 1H NMR, 13C NMR spectroscopy, X-ray diffraction (XRD) and TGA/DTA studies. These studies suggest formation of octahedral macrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II). The molar conductance values suggest nonelectrolytic nature for all the complexes. Thermogravimatric analysis shows that all the complexes are stable up to 600 °C. All these complexes have been tested against different human cancer cell lines i.e. human hepatocellular carcinoma (Hep3B), human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF7) and normal cells (PBMC). The newly synthesized 18-membered octaazamacrocyclic complexes during in vitro anticancer evaluation, displayed moderate to good cytotoxicity on liver (Hep3B), cervical (HeLa) and breast (MCF7) cancer cell lines, respectively. The most effective anticancer cadmium complex (C34H28N10CdO10) was found to be active with IC50 values, 2.44 ± 1.500, 3.55 ± 1.600 and 4.82 ± 1.400 in micro-molar on liver, cervical and breast cancer cell lines, respectively.

  9. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  10. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  11. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  12. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  13. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  14. 5 CFR 550.182 - Unscheduled duty.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Unscheduled duty. 550.182 Section 550.182 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.182 Unscheduled duty. (a) Unscheduled Duty Hours....

  15. 5 CFR 550.182 - Unscheduled duty.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Unscheduled duty. 550.182 Section 550.182 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.182 Unscheduled duty. (a) Unscheduled Duty Hours....

  16. 5 CFR 550.182 - Unscheduled duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Unscheduled duty. 550.182 Section 550.182 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.182 Unscheduled duty. (a) Unscheduled Duty Hours....

  17. 5 CFR 550.182 - Unscheduled duty.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Unscheduled duty. 550.182 Section 550.182 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.182 Unscheduled duty. (a) Unscheduled Duty Hours....

  18. 5 CFR 550.182 - Unscheduled duty.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Unscheduled duty. 550.182 Section 550.182 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Premium Pay Law Enforcement Availability Pay § 550.182 Unscheduled duty. (a) Unscheduled Duty Hours....

  19. 47 CFR 51.100 - General duty.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false General duty. 51.100 Section 51.100 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) INTERCONNECTION Telecommunications Carriers § 51.100 General duty. (a) Each telecommunications carrier has the duty: (1)...

  20. Duties to kin through a tragi-comic lens.

    PubMed

    Gillett, Grant; Hankey, Robin

    2014-06-01

    Euripides' Alcestis (1959) raises the issue of ethical duties within families and exposes the romantic postures and rhetoric that can dominate such discussions. Should anybody be asked to sacrifice themselves or even undergo significant health risks for members of their own family? (An issue that is also relevant in considering our duties to future generations in terms of the earth we leave to them.) The issue that is dramatized to a heroic level in Alcestis arises in live organ and tissue donation within a family and challenges the idea that families should be trusted to sort out solutions that they can all live with. Alcestis intensifies the debate because the sacrifice of one life for another is its topic but, in doing so, it exposes many traps lying in wait for ethicists and medical jurists who boldly enter such debates (where emotions create shifting ground on which angels fear to tread).

  1. An evaluation of knowledge, attitude, and practice of institutional ethics committee members from eastern India regarding ethics committee functioning and pharmacovigilance activities conducted during clinical trials: A pilot study

    PubMed Central

    Bhowmick, Subhrojyoti; Banerjee, Koyel; Sikdar, Shreya; Chatterjee, Tapan Kumar

    2014-01-01

    Purpose of study: The vital responsibility of Institutional Ethics Committee (IEC) members is to ensure the safety of the subjects participating in clinical trials. Hence, it is essential for IEC members to be aware of the common pharmacovigilance strategies followed during clinical trials. However, the information about the knowledge, attitude, and practice of IEC members regarding the pharmacovigilance activities followed during clinical trials is scarce worldwide, especially in India. Hence, this cross-sectional study was designed to assess the knowledge, attitude, and practice of IEC members of 10 hospitals of Kolkata, India. Materials and Methods: A cross-sectional study using a self-administered, validated questionnaire was conducted among 10 hospitals (five government and five corporate hospitals) in Kolkata conducting active clinical research and having functional Ethics Committees (ECs) in the month of September-November, 2012. An IEC approval was taken for this study. Two reminders were given to all EC members through telephone/e-mail for completion and returning of the forms. The filled in forms were returned to their respective Member Secretaries, from whom authors' collected the forms. Data were analyzed using SPSS version 16.0 software and MS-Excel 2007. Categorical data were analyzed using Chi-square test and a P < 0.05 was considered statistically significant. Results: Out of the 100 distributed questionnaires, 40 were returned of which 10 were not filled properly. Overall awareness regarding different pharmacovigilance terminologies and activities among EC members from nonmedical background (71.43%) was found to be more than that of the medical members (68.75%), though the figure was not statistically significant. Majority of the members (75%) felt that EC should decide compensation in case of a serious adverse event. Conclusion: The present study signifies that there is a low level of awareness in IEC members of Kolkata regarding pharmacovigilance

  2. Automobile or Other Conveyance and Adaptive Equipment Certificate of Eligibility for Veterans or Members of the Armed Forces With Amyotrophic Lateral Sclerosis Connected to Military Service. Final rule.

    PubMed

    2016-01-13

    The Department of Veterans Affairs (VA) published an Interim Final Rule on February 25, 2015, to amend its adjudication regulations to provide a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment for all veterans with service-connected amyotrophic lateral sclerosis (ALS) and servicemembers serving on active duty with ALS. The amendment authorized automatic issuance of a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment to all veterans with service-connected ALS and members of the Armed Forces serving on active duty with ALS. The intent of this final rule is to confirm the amendment made by the interim final rule without change.

  3. Sexual Assault and Sexual Harassment in the U.S. Military: Top-Line Estimates for Active-Duty Coast Guard Members from the 2014 RAND Military Workplace Study

    DTIC Science & Technology

    2014-01-01

    workplace in the past year.11 Whereas the estimated total and male percentages experiencing sexual harassment in the Coast Guard are lower than among...some people will have been assaulted more than once. Sexual harassment (particularly a sexually hostile workplace ) is more common than sexual assault...such high rates, sexual harassment and other MEO violations could affect unit cohesion, degrade mission effectiveness , and result in voluntary

  4. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... place and time specified in paragraph (b)(2) of this section by means of an electronic data interchange... 19 Customs Duties 1 2011-04-01 2011-04-01 false Electronic passenger and crew member departure... Electronic passenger and crew member departure manifests. (a) Definitions. The definitions contained in §...

  5. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... place and time specified in paragraph (b)(2) of this section by means of an electronic data interchange... 19 Customs Duties 1 2014-04-01 2014-04-01 false Electronic passenger and crew member departure... Electronic passenger and crew member departure manifests. (a) Definitions. The definitions contained in §...

  6. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... place and time specified in paragraph (b)(2) of this section by means of an electronic data interchange... 19 Customs Duties 1 2012-04-01 2012-04-01 false Electronic passenger and crew member departure... Electronic passenger and crew member departure manifests. (a) Definitions. The definitions contained in §...

  7. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... place and time specified in paragraph (b)(2) of this section by means of an electronic data interchange... 19 Customs Duties 1 2013-04-01 2013-04-01 false Electronic passenger and crew member departure... Electronic passenger and crew member departure manifests. (a) Definitions. The definitions contained in §...

  8. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... place and time specified in paragraph (b)(2) of this section by means of an electronic data interchange... 19 Customs Duties 1 2010-04-01 2010-04-01 false Electronic passenger and crew member departure... Electronic passenger and crew member departure manifests. (a) Definitions. The definitions contained in §...

  9. Experiences of Military Youth during a Family Member's Deployment: Changes, Challenges, and Opportunities

    ERIC Educational Resources Information Center

    Knobloch, Leanne K.; Pusateri, Kimberly B.; Ebata, Aaron T.; McGlaughlin, Patricia C.

    2015-01-01

    The deployment of a family member can be very distressing for military children, but it also can supply opportunities for growth. This study addresses calls for research on the changes, challenges, and opportunities facing youth during a family member's tour of duty. It uses the relational turbulence model to frame research questions about how…

  10. Academic Entrepreneurship and Traditional Academic Duties: Synergy or Rivalry?

    ERIC Educational Resources Information Center

    De Silva, Muthu

    2016-01-01

    This study investigates the influence of academic entrepreneurship on traditional academic duties carried out in a resource-constrained environment, particularly focusing on whether there is synergy or rivalry between these two activities. Using qualitative evidence, we discover that there are funding, resource, knowledge and skill and networking…

  11. 48 CFR 2806.502 - Duties and responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Program within the contracting activity and ensure that systems are established for the effective internal... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Duties and responsibilities. 2806.502 Section 2806.502 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Competition...

  12. Developing high-resolution urban scale heavy-duty truck emission inventory using the data-driven truck activity model output

    NASA Astrophysics Data System (ADS)

    Perugu, Harikishan; Wei, Heng; Yao, Zhuo

    2017-04-01

    Air quality modelers often rely on regional travel demand models to estimate the vehicle activity data for emission models, however, most of the current travel demand models can only output reliable person travel activity rather than goods/service specific travel activity. This paper presents the successful application of data-driven, Spatial Regression and output optimization Truck model (SPARE-Truck) to develop truck-related activity inputs for the mobile emission model, and eventually to produce truck specific gridded emissions. To validate the proposed methodology, the Cincinnati metropolitan area in United States was selected as a case study site. From the results, it is found that the truck miles traveled predicted using traditional methods tend to underestimate - overall 32% less than proposed model- truck miles traveled. The coefficient of determination values for different truck types range between 0.82 and 0.97, except the motor homes which showed least model fit with 0.51. Consequently, the emission inventories calculated from the traditional methods were also underestimated i.e. -37% for NOx, -35% for SO2, -43% for VOC, -43% for BC, -47% for OC and - 49% for PM2.5. Further, the proposed method also predicted within ∼7% of the national emission inventory for all pollutants. The bottom-up gridding methodology used in this paper could allocate the emissions to grid cell where more truck activity is expected, and it is verified against regional land-use data. Most importantly, using proposed method it is easy to segregate gridded emission inventory by truck type, which is of particular interest for decision makers, since currently there is no reliable method to test different truck-category specific travel-demand management strategies for air pollution control.

  13. Heavy Duty Vehicle Futures Analysis.

    SciTech Connect

    Askin, Amanda Christine; Barter, Garrett.; West, Todd H.; Manley, Dawn Kataoka

    2014-05-01

    This report describes work performed for an Early Career Research and Development project. This project developed a heavy-duty vehicle (HDV) sector model to assess the factors influencing alternative fuel and efficiency technology adoption. This model builds on a Sandia light duty vehicle sector model and provides a platform for assessing potential impacts of technological advancements developed at the Combustion Research Facility. Alternative fuel and technology adoption modeling is typically developed around a small set of scenarios. This HDV sector model segments the HDV sector and parameterizes input values, such as fuel prices, efficiencies, and vehicle costs. This parameterization enables sensitivity and trade space analyses to identify the inputs that are most associated with outputs of interest, such as diesel consumption and greenhouse gas emissions. Thus this analysis tool enables identification of the most significant HDV sector drivers that can be used to support energy security and climate change goals.

  14. Robust Glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI Family Member Protein, Is Critical for Oxidative Stress Resistance in Saccharomyces cerevisiae*

    PubMed Central

    Bankapalli, Kondalarao; Saladi, SreeDivya; Awadia, Sahezeel S.; Goswami, Arvind Vittal; Samaddar, Madhuja; D'Silva, Patrick

    2015-01-01

    Methylglyoxal (MG) is a reactive metabolic intermediate generated during various cellular biochemical reactions, including glycolysis. The accumulation of MG indiscriminately modifies proteins, including important cellular antioxidant machinery, leading to severe oxidative stress, which is implicated in multiple neurodegenerative disorders, aging, and cardiac disorders. Although cells possess efficient glyoxalase systems for detoxification, their functions are largely dependent on the glutathione cofactor, the availability of which is self-limiting under oxidative stress. Thus, higher organisms require alternate modes of reducing the MG-mediated toxicity and maintaining redox balance. In this report, we demonstrate that Hsp31 protein, a member of the ThiJ/DJ-1/PfpI family in Saccharomyces cerevisiae, plays an indispensable role in regulating redox homeostasis. Our results show that Hsp31 possesses robust glutathione-independent methylglyoxalase activity and suppresses MG-mediated toxicity and ROS levels as compared with another paralog, Hsp34. On the other hand, glyoxalase-defective mutants of Hsp31 were found highly compromised in regulating the ROS levels. Additionally, Hsp31 maintains cellular glutathione and NADPH levels, thus conferring protection against oxidative stress, and Hsp31 relocalizes to mitochondria to provide cytoprotection to the organelle under oxidative stress conditions. Importantly, human DJ-1, which is implicated in the familial form of Parkinson disease, complements the function of Hsp31 by suppressing methylglyoxal and oxidative stress, thus signifying the importance of these proteins in the maintenance of ROS homeostasis across phylogeny. PMID:26370081

  15. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis.

    PubMed

    Huminiecki, Lukasz; Gorn, Michael; Suchting, Steven; Poulsom, Richard; Bicknell, Roy

    2002-04-01

    We have used bioinformatic data mining to identify a novel, endothelial-specific gene encoding a protein with homology to the axon guidance protein roundabout (ROBO1). The new gene has been called magic roundabout (ROBO4; GenBank acc. no. AF361473) and is smaller than other members of the roundabout gene family. Thus, in the extracellular region, magic roundabout has only two of the five immunoglobulin and two of the three fibronectin domains present in other roundabout genes. Expression of magic roundabout in vitro was detected in only endothelial cells and was greater in cells exposed to hypoxia. In situ hybridization and immunohistochemistry validated the bioinformatic prediction that magic roundabout expression would be endothelial specific in vivo. Magic roundabout expression in the adult was restricted exclusively to sites of active angiogenesis, notably tumor vessels. The identification of magic roundabout shows that the roundabout gene family extends beyond neuronal tissue and that roundabout/slit interactions are likely to have a role in angiogenesis.

  16. The Porcine Chloride Channel Calcium-Activated Family Member pCLCA4a Mirrors Lung Expression of the Human hCLCA4

    PubMed Central

    Plog, Stephanie; Grötzsch, Tanja; Klymiuk, Nikolai; Kobalz, Ursula; Gruber, Achim D.

    2012-01-01

    Pig models of cystic fibrosis (CF) have recently been established that are expected to mimic the human disease closer than mouse models do. The human CLCA (originally named chloride channels, calcium-activated) member hCLCA4 is considered a potential modifier of disease severity in CF, but its murine ortholog, mCLCA6, is not expressed in the mouse lung. Here, we have characterized the genomic structure, protein processing, and tissue expression patterns of the porcine ortholog to hCLCA4, pCLCA4a. The genomic structure and cellular protein processing of pCLCA4a were found to closely mirror those of hCLCA4 and mCLCA6. Similar to human lung, pCLCA4a mRNA was strongly expressed in porcine lungs, and the pCLCA4a protein was immunohistochemically detected on the apical membranes of tracheal and bronchial epithelial cells. This stands in sharp contrast to mouse mCLCA6, which has been detected exclusively in intestinal epithelia but not the murine lung. The results may add to the understanding of species-specific differences in the CF phenotype and support the notion that the CF pig model may be more suitable than murine models to study the role of hCLCA4. PMID:22205680

  17. Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.

    PubMed Central

    Lamb, David C; Fowler, Kay; Kieser, Tobias; Manning, Nigel; Podust, Larissa M; Waterman, Michael R; Kelly, Diane E; Kelly, Steven L

    2002-01-01

    The annotation of the genome sequence of Streptomyces coelicolor A3(2) revealed a cytochrome P450 (CYP) resembling various sterol 14alpha-demethylases (CYP51). The putative CYP open reading frame (SC7E4.20) was cloned with a tetrahistidine tag appended to the C-terminus and expressed in Escherichia coli. Protein purified to electrophoretic homogeneity was observed to bind the 14-methylated sterols lanosterol and 24-methylene-24,25-dihydrolanosterol (24-MDL). Reconstitution experiments with E. coli reductase partners confirmed activity in 14alpha-demethylation for 24-MDL, but not lanosterol. An S. coelicolor A3(2) mutant containing a transposon insertion in the CYP51 gene, which will abolish synthesis of the functional haemoprotein, was isolated as a viable strain, the first time a CYP51 has been identified as non-essential. The role of this CYP in bacteria is intriguing. No sterol product was detected in non-saponifiable cell extracts of the parent S. coelicolor A3(2) strain or of the mutant. S. coelicolor A3(2) CYP51 contains very few of the conserved CYP51 residues and, even though it can catalyse 14alpha-demethylation, it probably has another function in Streptomyces. We propose that it is a member of a new CYP51 subfamily. PMID:12023899

  18. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection of... Vehicles § 86.1811-10 Emission standards for light-duty vehicles, light-duty trucks and...

  19. 40 CFR 86.1811-09 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-09 Section 86.1811-09 Protection of... Vehicles § 86.1811-09 Emission standards for light-duty vehicles, light-duty trucks and...

  20. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection of... Vehicles § 86.1811-10 Emission standards for light-duty vehicles, light-duty trucks and medium-duty... standards apply for purposes of in-use testing only and does not apply to certification or...

  1. Solving the Dilemma of State Responses to Cyberattacks: A Justification for the use of Active Defenses Against States Who Neglect Their Duty to Prevent

    DTIC Science & Technology

    2009-04-01

    Security professionals can set up active defenses to automatically respond to attacks against critical systems, or can carry them out manually .158 For the...Michael Schmitt’s use of force analysis). 361 See WlNGFIELD, supra note 322, at 6-7; WlNGFIELD, supra note 48, at 115-29 (2000); Vida Antolin-Jenkins...criminal misuse of information technologies. See supra notes 382, 394-98, 400 and accompanying text; UNITED NATIONS MANUAL ON THE PREVENTION AND

  2. Incidence of Campylobacter infections among service members of the active and reserve components of the U.S. Armed Forces and among other beneficiaries of the Military Health System, 2000-2013.

    PubMed

    2014-12-01

    This report reviews the incidence of illness due to Campylobacter bacteria based on diagnoses recorded in healthcare records and reported through the Armed Forces reportable medical event (RME) system. During 2000-2013, incident cases of Campylobacter infection were diagnosed in 1,393 active component service members, 188 members of the reserve component, and 3,891 retirees and family members. Among members of the active component, incidence rates tended to be higher among females, those aged 40 years or older, members of the Army and Air Force, and offi cers. Incidence rates declined from 2002 through 2007 but have risen steadily since, especially from 2010 through 2013. Among retirees and family members, the highest numbers of cases were diagnosed among those aged 5 years or younger and those aged 75 years or older. Cases identifi ed through RME reports (n=2,938) showed the highest numbers of cases in May-August, especially July, and that cases reported from Fort Shafter, HI, accounted for 20% of all cases. Measures and precautions important in preventing Campylobacter infections as well as other food- and waterborne infections are discussed.

  3. Results of community deliberation about social impacts of ecological restoration: comparing public input of self-selected versus actively engaged community members.

    PubMed

    Harris, Charles C; Nielsen, Erik A; Becker, Dennis R; Blahna, Dale J; McLaughlin, William J

    2012-08-01

    Participatory processes for obtaining residents' input about community impacts of proposed environmental management actions have long raised concerns about who participates in public involvement efforts and whose interests they represent. This study explored methods of broad-based involvement and the role of deliberation in social impact assessment. Interactive community forums were conducted in 27 communities to solicit public input on proposed alternatives for recovering wild salmon in the Pacific Northwest US. Individuals identified by fellow residents as most active and involved in community affairs ("AE residents") were invited to participate in deliberations about likely social impacts of proposed engineering and ecological actions such as dam removal. Judgments of these AE participants about community impacts were compared with the judgments of residents motivated to attend a forum out of personal interest, who were designated as self-selected ("SS") participants. While the magnitude of impacts rated by SS participants across all communities differed significantly from AE participants' ratings, in-depth analysis of results from two community case studies found that both AE and SS participants identified a large and diverse set of unique impacts, as well as many of the same kinds of impacts. Thus, inclusion of both kinds of residents resulted in a greater range of impacts for consideration in the environmental impact study. The case study results also found that the extent to which similar kinds of impacts are specified by AE and SS group members can differ by type of community. Study results caution against simplistic conclusions drawn from this approach to community-wide public participation. Nonetheless, the results affirm that deliberative methods for community-based impact assessment involving both AE and SS residents can provide a more complete picture of perceived impacts of proposed restoration activities.

  4. The Arabidopsis LUT1 locus encodes a member of the cytochrome P450 family that is required for carotenoid ε-ring hydroxylation activity

    PubMed Central

    Tian, Li; Musetti, Valeria; Kim, Joonyul; Magallanes-Lundback, Maria; DellaPenna, Dean

    2004-01-01

    Lutein, a dihydroxy xanthophyll, is the most abundant carotenoid in plant photosynthetic tissues and plays crucial structural and functional roles in the light-harvesting complexes. Carotenoid β-and ε-hydroxylases catalyze the formation of lutein from α-carotene (β,ε-carotene). In contrast to the well studied β-hydroxylases that have been cloned and characterized from many organisms, the ε-hydroxylase has only been genetically defined by the lut1 mutation in Arabidopsis. We have isolated the LUT1 gene by positional cloning and found that, in contrast to all known carotenoid hydroxylases, which are the nonheme diiron monooxygenases, LUT1 encodes a cytochrome P450-type monooxygenase, CYP97C1. Introduction of a null mutant allele of LUT1, lut1-3, into the β-hydroxylase 1/β-hydroxylase 2 (b1 b2) double-mutant background, in which both Arabidopsis β-hydroxylases are disrupted, yielded a genotype (lut1-3 b1 b2) in which all three known carotenoid hydroxylase activities are eliminated. Surprisingly, hydroxylated β-rings were still produced in lut1-3 b1 b2, suggesting that a fourth unknown carotenoid β-hydroxylase exists in vivo that is structurally unrelated to β-hydroxylase 1 or 2. A second chloroplast-targeted member of the CYP97 family, CYP97A3, is 49% identical to LUT1 and hypothesized as a likely candidate for this additional β-ring hydroxylation activity. Overall, LUT1 defines a class of carotenoid hydroxylases that has evolved independently from and uses a different mechanism than nonheme diiron β-hydroxylases. PMID:14709673

  5. Fam57b (Family with Sequence Similarity 57, Member B), a Novel Peroxisome Proliferator-activated Receptor γ Target Gene That Regulates Adipogenesis through Ceramide Synthesis*

    PubMed Central

    Yamashita-Sugahara, Yzumi; Tokuzawa, Yoshimi; Nakachi, Yutaka; Kanesaki-Yatsuka, Yukiko; Matsumoto, Masahito; Mizuno, Yosuke; Okazaki, Yasushi

    2013-01-01

    This report identifies a novel gene encoding Fam57b (family with sequence similarity 57, member B) as a novel peroxisome proliferator-activated receptor γ (PPARγ)-responsive transmembrane gene that is related to obesity. The gene was identified based on an integrated bioinformatics analysis of the following three expression profiling data sets: adipocyte differentiation of mouse stromal cells (ST2 cells), adipose tissues from obesity mice, and siRNA-mediated knockdown of Pparγ using ST2 cells. Fam57b consists of three variants expressed from different promoters and contains a Tram-Lag1-CLN8 domain that is related to ceramide synthase. Reporter and ChIP assays showed that Fam57b variant 2 is a bona fide PPARγ target gene in ST2 cells. Fam57b was up-regulated during adipocyte differentiation, suggesting that FAM57B is involved in this process. Surprisingly, FAM57B overexpression inhibited adipogenesis, and siRNA-mediated knockdown promoted adipocyte differentiation. Analysis of the ceramide content by lipid assay found that ceramides were in fact augmented in FAM57B-overexpressing ST2 cells. We also confirmed that ceramide inhibits adipogenesis. Therefore, the aforementioned results of FAM57B overexpression and siRNA experiments are reconciled by ceramide synthesis. In summary, we present in vitro evidence showing that PPARγ regulates Fam57b transcription during the adipogenesis of ST2 cells. In addition, our results suggest that PPARγ activation contributes to the regulation of ceramide metabolism during adipogenesis via FAM57B. PMID:23275342

  6. Astronaut Norman Thagard rests on middeck while other team is on duty

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Astronaut Norman E. Thagard, mission specialist for the 'silver' team, rests on the middeck while the 'gold' team is on duty in the science module. Don L. Lind, left, 'gold' team member, meanwhile participates in autogenic feedback training (AFT), designed to help flight crewmembers overcome the effects of zero-gravity adaptation.

  7. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  8. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  9. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  10. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  11. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  12. Duty cycle dependence of ultrasound enhanced thrombolysis in a human clot model.

    PubMed

    Meunier, Jason M; Holland, Christy K; Lindsell, Christopher J; Shaw, George J

    2007-04-01

    Combined ultrasound and tissue plasminogen activator (rt-PA) therapy, or ultrasound enhanced thrombolysis (UET), has been shown to improve recanalization in patients with acute ischemic stroke. We measured the effect of ultrasound duty cycle on the lytic efficacy of 120 kHz UET in an in vitro human clot model. The hypothesis was that an increase in duty cycle increases rt-PA lytic efficacy. Human whole blood clots were exposed to 120-kHz ultrasound and rt-PA for 30 min in human plasma. The duty cycle ranged from 0% to 80%, where 0% represents sham exposure. Clot lytic rate was measured by recording the clot width over time. The clot width after 30 min exposure to rt-PA and ultrasound decreases with increasing duty cycle. The initial lytic rate increased linearly with duty cycle.

  13. The Trichoderma reesei Cry1 Protein Is a Member of the Cryptochrome/Photolyase Family with 6–4 Photoproduct Repair Activity

    PubMed Central

    Guzmán-Moreno, Jesús; Flores-Martínez, Alberto; Brieba, Luis G.; Herrera-Estrella, Alfredo

    2014-01-01

    DNA-photolyases use UV-visible light to repair DNA damage caused by UV radiation. The two major types of DNA damage are cyclobutane pyrimidine dimers (CPD) and 6–4 photoproducts (6-4PP), which are repaired under illumination by CPD and 6–4 photolyases, respectively. Cryptochromes are proteins related to DNA photolyases with strongly reduced or lost DNA repair activity, and have been shown to function as blue-light photoreceptors and to play important roles in circadian rhythms in plants and animals. Both photolyases and cryptochromes belong to the cryptochrome/photolyase family, and are widely distributed in all organisms. Here we describe the characterization of cry1, a member of the cryptochrome/photolyase protein family of the filamentous fungus Trichoderma reesei. We determined that cry1 transcript accumulates when the fungus is exposed to light, and that such accumulation depends on the photoreceptor Blr1 and is modulated by Envoy. Conidia of cry1 mutants show decreased photorepair capacity of DNA damage caused by UV light. In contrast, strains over-expressing Cry1 show increased repair, as compared to the parental strain even in the dark. These observations suggest that Cry1 may be stimulating other systems involved in DNA repair, such as the nucleotide excision repair system. We show that Cry1, heterologously expressed and purified from E. coli, is capable of binding to undamaged and 6-4PP damaged DNA. Photorepair assays in vitro clearly show that Cry1 repairs 6-4PP, but not CPD and Dewar DNA lesions. PMID:24964051

  14. User Working Group Members

    Atmospheric Science Data Center

    2014-04-29

    User Working Group Members   Mail for the entire group may be directed to:  larc-asdc-uwg@lists.nasa.gov   Member Status Affiliation E-mail Contact Bob Holz (Co-Chair in 2010) Co-Chair University of ...

  15. Collapsable seal member

    DOEpatents

    Sherrell, Dennis L.

    1990-01-01

    A hollow, collapsable seal member normally disposed in a natural expanded state offering fail-safe pressure sealing against a seating surface and adapted to be evacuated by a vacuum force for collapsing the seal member to disengage the same from said seating surface.

  16. PSI Member Profile.

    ERIC Educational Resources Information Center

    Professional Secretaries International, Kansas City, MO.

    A survey of 2,700 of the 27,000 members of Professional Secretaries International received 755 responses yielding the following profile of secretarial workers: (1) the average member is female, about 45 years old, married with no dependents living at home, and owns a single-family home in the suburbs; (2) most respondents have worked in office or…

  17. Advisory Council Member.

    ERIC Educational Resources Information Center

    Illinois State Board of Vocational Education and Rehabilitation, Springfield. Div. of Vocational and Technical Education.

    The pamphlet is directed toward the new member of a career education advisory council. It explains why advisory councils are needed and why an individual should join one. An advisory council is defined as a group of persons selected to collectively advise regarding career education efforts within the community, whose members are predominantly from…

  18. Is there a moral duty to die?

    PubMed

    Corlett, J A

    2001-01-01

    In recent years, there has been a great deal of philosophical discussion about the alleged moral right to die. If there is such a moral right, then it would seem to imply a moral duty of others to not interfere with the exercise of the right. And this might have important implications for public policy insofar as public policy ought to track what is morally right. But is there a moral duty to die? If so, under what conditions, if any, ought one to have such a duty, and why? In this paper, I distinguish between different moral grounds for the putative moral duty to die: deontological, intuitionist, and contractarian. Subsequently, I argue in support of Paul Menzel's theory of health care distribution. More precisely, I concur with his claim that there is a moral duty to die inexpensively in health care contexts. Then I provide and defend a philosophical analysis of the conditions in which such a duty could exist.

  19. Individual rights versus societal duties.

    PubMed

    Vermeersch, E

    1999-10-29

    In 'bioethics', the rights to self-determination and to informed consent of the patient are prerequisites to every medical decision: paternalism is no longer a justifiable attitude. Hence, it seems that compulsory vaccination is an unacceptable praxis. Even John Stuart Mill. however, took into account other values: e.g. the duty not to harm others. This article is dedicated to the analysis of the historical development of these values and to their relevance for the ethics of vaccination. The acceptability of coercion is upheld, but no clear-cut answers are given in general: in every case the pros and cons of coercion are to be weighed carefully against each other.

  20. [On the moral dutifulness of using vaccinations].

    PubMed

    Refolo, P; González-Melado, F J; Di Pietro, M L

    2015-01-01

    People had contradictory opinions on using vaccinations over time: an initial opposition, later large favour and then doubts and perplexities. In recent times, some movements, blogs and associations stigmatize the use of vaccinations and they are increasingly asking to remove mandatory vaccinations in countries where they are active. The impact of the antivaccination campaigns should not be underestimated, considering that, for example, in Italy, due to these campaigns, adhesions to vaccinations are decreasing by 1% per year, and in reference to rubella and measles, adhesions decreased by 25% in some regions of the country. Overcoming the choice between mandatory and recommended vaccinations, the paper deals with the topic of using preventive immunization starting from the concept of "moral dutifulness".

  1. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  2. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  3. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  4. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  5. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  6. 78 FR 53128 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... the absence of both de jure and de facto government control over export activities. All firms listed... countervailing duties on entries of subject merchandise entered, or withdrawn from warehouse, for...

  7. Genome-wide identification and expression analysis of the mitogen-activated protein kinase gene family from banana suggest involvement of specific members in different stages of fruit ripening.

    PubMed

    Asif, Mehar Hasan; Lakhwani, Deepika; Pathak, Sumya; Bhambhani, Sweta; Bag, Sumit K; Trivedi, Prabodh Kumar

    2014-03-01

    Mitogen-activated protein kinases (MAPKs) are important components of the tripartite mitogen-activated protein kinase signaling cascade and play an important role in plant growth and development. Although members of the MAPK gene family have been identified in model plants, little information is available regarding this gene family in fruit crops. In this study, we carried out a computational analysis using the Musa Genome database to identify members of the MAPK gene family in banana, an economically important crop and the most popular fruit worldwide. Our analysis identified 25 members of the MAP kinase (MAPK or MPK) gene family. Phylogenetic analyses of MPKs in Arabidopsis, Oryza, and Populus have classified these MPKs into four subgroups. The presence of conserved domains in the deduced amino acid sequences, phylogeny, and genomic organization strongly support their identity as members of the MPK gene family. Expression analysis during ethylene-induced banana fruit ripening suggests the involvement of several MPKs in the ethylene signal transduction pathway that are necessary for banana fruit ripening. Analysis of the cis-regulatory elements in the promoter regions and the involvement of the identified MPKs in various cellular processes, as analyzed using Pathway Studio, suggest a role for the banana MPK gene family in diverse functions related to growth, development, and the stress response. This report is the first concerning the identification of members of a gene family and the elucidation of their role in various processes using the Musa Genome database.

  8. 20 CFR 1002.57 - Is all service as a member of the National Guard considered “service in the uniformed services?”

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Reserve component of the Army, or, in the case of the Air National Guard, of the Air Force. Simultaneously... authority includes active duty performed under Title 10 of the United States Code. Service under Federal authority also includes duty under Title 32 of the United States Code, such as active duty for...

  9. 19 CFR 159.38 - Rates for estimated duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.38 Rates for estimated duties. For purposes of calculating estimated duties, the port director shall use the rate or rates... 19 Customs Duties 2 2010-04-01 2010-04-01 false Rates for estimated duties. 159.38 Section...

  10. 19 CFR 159.38 - Rates for estimated duties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.38 Rates for estimated duties. For purposes of calculating estimated duties, the port director shall use the rate or rates... 19 Customs Duties 2 2011-04-01 2011-04-01 false Rates for estimated duties. 159.38 Section...

  11. Business & Office Accounting/Bookkeeping Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for five occupations in the business and office accounting/bookkeeping series. Each occupation is divided into four to six duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has…

  12. Banking and Financial Services Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for five occupations in the banking and financial services series. Each occupation is divided into seven or eight duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been…

  13. Rh(III)-Catalyzed Diastereoselective Annulation of Amides with Quinone Monoacetals: Access to Bridged Nine-Membered Heterocycles via C-H Activation.

    PubMed

    Yang, Wei; Dong, Jinhuan; Wang, Jingyi; Xu, Xianxiu

    2017-02-03

    An unprecedented Rh(III)-catalyzed annulation of various benzamides and acrylamides with quinone monoacetals was developed for the facile and efficient one-pot synthesis of bridged nine-membered benzo[c]azonine-1,5(2H)-diones and 2-azabicyclo[4.3.1]dec-4-ene-3,8-diones. It is the first example of synthesis of nine-membered heterocycles through Rh(III)-catalyzed C-H bond functionalization, and both aryl and vinyl C-H bonds are tolerant in this reaction. A plausible mechanism is proposed on the basis of control experiments.

  14. Active Duty (AD) Claims Payment Program

    DTIC Science & Technology

    1991-08-26

    Claims Payment Program References: (a) Sections 1073 and 1074(c) of title 10, United States Code (b) DoD 6010.8-R, "Civilian Health and Medical Program...Provider) 1. This payment was calculated under the CHAMPUS DRG-based payment system as directed by Sections 1073 and 1074(c) of title 10, United

  15. Prevalence of Hypertension Among Active Duty Personnel

    DTIC Science & Technology

    1990-04-13

    coronary heart disease , and renal disease , which account for a large proportion of adult deaths in the United States. The purpose of this study was to...cardiovascular diseases --stroke, rheumatic heart disease , coronary heart disease , and hypertension--hypertension is the most prevalent, afflicting approximately 30...factor, in conjunction with the fact that hypertension is one of the most modifiable risk factors for heart disease and stroke (Alderman,

  16. Relationships between diagnoses of sexually transmitted infections and urinary tract infections among male service members diagnosed with urethritis, active component, U.S. Armed Forces, 2000-2013.

    PubMed

    2014-07-01

    A previous MSMR report found that 42.8% of all incident (first-time) urinary tract infections (UTIs) in males, but only 0.4% of such UTIs in females, were diagnosed as "urethritis, unspecified" (ICD-9: 597.80). This study explored the possibility that many of the diagnoses of urethritis in males represented sexually transmitted infections (STIs), even though ICD-9: 597.80 is explicitly reserved for cases of urethritis that are deemed to not be sexually transmitted. Examined were relationships between diagnoses of urethritis, diagnoses of STIs, and recurrent diagnoses of UTIs. Male service members who received a diagnosis of "urethritis, unspecified" (ICD-9: 597.80) had an increased risk of a subsequent UTI diagnosis, especially of "urethritis, unspecified," compared to all male service members. Most service members who were diagnosed with "urethritis, unspecified" had no documented diagnoses of an STI in their Military Health System health records; however, recurrent UTIs were more common among service members who did have documented STIs. The most commonly diagnosed STIs in this study were "other non-gonococcal urethritis" (which includes that caused by Chlamydia trachomatis) and gonorrhea.

  17. The Economics of Perception: Potential Effect regarding Institutional Uses of Recovered Facilities and Administrative Costs upon a Faculty Member's Decision to Engage in Sponsored Research Activity

    ERIC Educational Resources Information Center

    Hatfield, Anne Elizabeth

    2012-01-01

    There is one aspect of sponsored research associated with higher education's research enterprise that often places the institution's research administrators and the institution's faculty members in conflict with each other; the recovery of Facilities and Administrative (F&A) costs associated with sponsored research projects (Sedwick, 2009;…

  18. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.

    PubMed

    Wang, Wei; Huang, Xuan; Xin, Hong-Bo; Fu, Mingui; Xue, Aimin; Wu, Zhao-Hui

    2015-05-22

    DNA damage-induced NF-κB activation plays a critical role in regulating cellular response to genotoxic stress. However, the molecular mechanisms controlling the magnitude and duration of this genotoxic NF-κB signaling cascade are poorly understood. We recently demonstrated that genotoxic NF-κB activation is regulated by reversible ubiquitination of several essential mediators involved in this signaling pathway. Here we show that TRAF family member-associated NF-κB activator (TANK) negatively regulates NF-κB activation by DNA damage via inhibiting ubiquitination of TRAF6. Despite the lack of a deubiquitination enzyme domain, TANK has been shown to negatively regulate the ubiquitination of TRAF proteins. We found TANK formed a complex with MCPIP1 (also known as ZC3H12A) and a deubiquitinase, USP10, which was essential for the USP10-dependent deubiquitination of TRAF6 and the resolution of genotoxic NF-κB activation upon DNA damage. Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated deletion of TANK in human cells significantly enhanced NF-κB activation by genotoxic treatment, resulting in enhanced cell survival and increased inflammatory cytokine production. Furthermore, we found that the TANK-MCPIP1-USP10 complex also decreased TRAF6 ubiquitination in cells treated with IL-1β or LPS. In accordance, depletion of USP10 enhanced NF-κB activation induced by IL-1β or LPS. Collectively, our data demonstrate that TANK serves as an important negative regulator of NF-κB signaling cascades induced by genotoxic stress and IL-1R/Toll-like receptor stimulation in a manner dependent on MCPIP1/USP10-mediated TRAF6 deubiquitination.

  19. Dependence of pulsed focused ultrasound induced thrombolysis on duty cycle and cavitation bubble size distribution.

    PubMed

    Xu, Shanshan; Zong, Yujin; Feng, Yi; Liu, Runna; Liu, Xiaodong; Hu, Yaxin; Han, Shimin; Wan, Mingxi

    2015-01-01

    In this study, we investigated the relationship between the efficiency of pulsed, focused ultrasound (FUS)-induced thrombolysis, the duty cycle (2.3%, 9%, and 18%) and the size distribution of cavitation bubbles. The efficiency of thrombolysis was evaluated through the degree of mechanical fragmentation, namely the number, mass, and size of clot debris particles. First, we found that the total number and mass of clot debris particles were highest when a duty cycle of 9% was used and that the mean diameter of clot debris particles was smallest. Second, we found that the size distribution of cavitation bubbles was mainly centered around the linear resonance radius (2.5μm) of the emission frequency (1.2MHz) of the FUS transducer when a 9% duty cycle was used, while the majority of cavitation bubbles became smaller or larger than the linear resonance radius when a 2.3% or 18% duty cycle was used. In addition, the inertial cavitation dose from the treatment performed at 9% duty cycle was much higher than the dose obtained with the other two duty cycles. The data presented here suggest that there is an optimal duty cycle at which the thrombolysis efficiency and cavitation activity are strongest. They further indicate that using a pulsed FUS may help control the size distribution of cavitation nuclei within an active size range, which we found to be near the linear resonance radius of the emission frequency of the FUS transducer.

  20. Determination of the duty cycle of WLAN for realistic radio frequency electromagnetic field exposure assessment.

    PubMed

    Joseph, Wout; Pareit, Daan; Vermeeren, Günter; Naudts, Dries; Verloock, Leen; Martens, Luc; Moerman, Ingrid

    2013-01-01

    Wireless Local Area Networks (WLANs) are commonly deployed in various environments. The WLAN data packets are not transmitted continuously but often worst-case exposure of WLAN is assessed, assuming 100% activity and leading to huge overestimations. Actual duty cycles of WLAN are thus of importance for time-averaging of exposure when checking compliance with international guidelines on limiting adverse health effects. In this paper, duty cycles of WLAN using Wi-Fi technology are determined for exposure assessment on large scale at 179 locations for different environments and activities (file transfer, video streaming, audio, surfing on the internet, etc.). The median duty cycle equals 1.4% and the 95th percentile is 10.4% (standard deviation SD = 6.4%). Largest duty cycles are observed in urban and industrial environments. For actual applications, the theoretical upper limit for the WLAN duty cycle is 69.8% and 94.7% for maximum and minimum physical data rate, respectively. For lower data rates, higher duty cycles will occur. Although counterintuitive at first sight, poor WLAN connections result in higher possible exposures. File transfer at maximum data rate results in median duty cycles of 47.6% (SD = 16%), while it results in median values of 91.5% (SD = 18%) at minimum data rate. Surfing and audio streaming are less intensively using the wireless medium and therefore have median duty cycles lower than 3.2% (SD = 0.5-7.5%). For a specific example, overestimations up to a factor 8 for electric fields occur, when considering 100% activity compared to realistic duty cycles.