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Sample records for active duty members

  1. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  2. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  3. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  4. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  5. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  6. Risk Factors for Clinically Significant Intimate Partner Violence among Active-Duty Members

    ERIC Educational Resources Information Center

    Smith Slep, Amy M.; Foran, Heather M.; Heyman, Richard E.; Snarr, Jeffery D.

    2011-01-01

    Hypothesized risk factors for men's and women's clinically significant intimate partner violence (CS-IPV) from four ecological levels (i.e., individual, family, workplace, community) were tested in a representative sample of active-duty U.S. Air Force members (N = 42,744). When considered together, we expected only individual and family factors to…

  7. Qualitative examination of cognitive change during PTSD treatment for active duty service members.

    PubMed

    Dondanville, Katherine A; Blankenship, Abby E; Molino, Alma; Resick, Patricia A; Wachen, Jennifer Schuster; Mintz, Jim; Yarvis, Jeffrey S; Litz, Brett T; Borah, Elisa V; Roache, John D; Young-McCaughan, Stacey; Hembree, Elizabeth A; Peterson, Alan L

    2016-04-01

    The current study investigated changes in service members' cognitions over the course of Cognitive Processing Therapy (CPT) for posttraumatic stress disorder (PTSD). Sixty-three active duty service members with PTSD were drawn from 2 randomized controlled trials of CPT-Cognitive Only (CPT-C). Participants wrote an impact statement about the meaning of their index trauma at the beginning and again at the end of therapy. Clauses from each impact statement were qualitatively coded into three categories for analysis: assimilation, accommodation, and overaccommodation. The PTSD Checklist, Posttraumatic Symptom Scale-Interview Version, and the Beck Depression Inventory-II were administered at baseline and posttreatment. Repeated measures analyses documented a significant decrease in the percentage of assimilated or overaccommodated statements and an increase in the percentage of accommodated statements from the beginning to the end of treatment. Changes in accommodated statements over the course of treatment were negatively associated with PTSD and depression symptom severity, while statements indicative of overaccommodation were positively associated with both PTSD and depression symptom severity. Treatment responders had fewer overaccommodated and more accommodated statements. Findings suggest that CPT-C changes cognitions over the course of treatment. Methodological limitations and the lack of association between assimilation and PTSD symptom severity are further discussed. PMID:26874683

  8. Army Active Duty Members' Linkage to Veterans Health Administration Services After Deployments to Iraq or Afghanistan and Following Separation.

    PubMed

    Vanneman, Megan E; Harris, Alex H S; Chen, Cheng; Mohr, Beth A; Adams, Rachel Sayko; Williams, Thomas V; Larson, Mary Jo

    2015-10-01

    This study described the rate and predictors of Operation Enduring Freedom/Operation Iraqi Freedom active duty Army members' enrollment in and use of Veterans Health Administration (VHA) services (linkage), as well as variation in linkage rates by VHA facility. We used a multivariate mixed effect regression model to predict linkage to VHA, and also calculated linkage rates in the catchment areas of each facility (n = 158). The sample included 151,122 active duty members who deployed to Iraq or Afghanistan and then separated from the Army between fiscal years 2008 and 2012. Approximately 48% of the active duty members separating utilized VHA as an enrollee within one year. There was significant variation in linkage rates by VHA facilities (31-72%). The most notable variables associated with greater linkage included probable serious injury during index deployment (odds ratio = 1.81), separation because of disability (odds ratio = 2.86), and various measures of receipt of VHA care before and after separation. Information about the individual characteristics that predict greater or lesser linkage to VHA services can be used to improve delivery of health care services at VHA as well as outreach efforts to active duty Army members. PMID:26444467

  9. Suicide Attempt Characteristics Among Veterans and Active-Duty Service Members Receiving Mental Health Services: A Pooled Data Analysis

    PubMed Central

    Villatte, Jennifer L.; O’Connor, Stephen S.; Leitner, Rebecca; Kerbrat, Amanda H.; Johnson, Lora L.; Gutierrez, Peter M.

    2015-01-01

    Past suicidal behaviors are among the strongest and most consistent predictors of eventual suicide and may be particularly salient in military suicide. The current study compared characteristics of suicide attempts in veterans (N = 746) and active-duty service members (N = 1,013) receiving treatment for acute suicide risk. Baseline data from six randomized controlled trials were pooled and analyzed using robust regression. Service members had greater odds of having attempted suicide relative to veterans, though there were no differences in number of attempts made. Service members also had higher rates of premilitary suicide attempts and nonsuicidal self-injury (NSSI). Veterans disproportionately attempted suicide by means of overdose. In veterans, combat deployment was associated with lower odds of lifetime suicide attempt, while history of NSSI was associated with greater attempt odds. Neither was significantly associated with lifetime suicide attempt in service members. Implications for suicide assessment and treatment are discussed. PMID:26740909

  10. A Case Report of Supplement-Induced Hepatitis in an Active Duty Service Member.

    PubMed

    Brazeau, Michael J; Castaneda, Joni L; Huitron, Sonny S; Wang, James

    2015-07-01

    The incidence of drug-induced hepatic injury has been increasing as a result of more widespread use of workout supplements containing anabolic steroids to increase muscle mass. Synthetic androgenic steroids are shown to cause cholestatic liver injury, but the exact mechanism of injury is not completely understood. We present a case of a healthy, young, active duty Army male soldier who developed pruritis and jaundice shortly after starting to take a body-building supplement containing anabolic steroids, and was subsequently found to have significant biopsy proven drug-induced liver injury. PMID:26126259

  11. Cholestatic liver injury associated with dietary supplements: a report of five cases in active duty service members.

    PubMed

    Peterson, Brandon R; DeRoche, Tom C; Huber, Aaron R; Shields, William W

    2013-10-01

    The use of dietary supplements (DS) is common in the active duty population, often without physician knowledge or approval. DS have been associated with drug-induced liver injury, with rare cases resulting in liver failure or death. We report five cases of transient drug-induced liver injury temporally associated with the use of a total of six DS in active duty service members. All patients presented with elevated serum bilirubin and liver-associated enzymes: three patients had a cholestatic liver enzyme pattern, one had a hepatocellular pattern, and one had a mixed pattern. In all cases, percutaneous needle core biopsies of the liver were obtained and demonstrated a cholestatic pattern of injury with variable periportal fibrosis. Causality was considered highly probable for three cases, probable for one case, and possible for one case. Hepatotoxicity has been previously associated with four of the supplements in our cases. For the two remaining supplements, C4 Extreme and Animal Stak, we are unaware of any previous reports of hepatotoxicity. Health care professionals, in particular military physicians, should be aware of the potential risk of these supplements and be prepared to discuss these risks with their patients. PMID:24083935

  12. Supporting School Success for Homeless Children of Veterans and Active Duty Military Members. Best Practices in Interagency Collaboration

    ERIC Educational Resources Information Center

    National Center for Homeless Education at SERVE, 2011

    2011-01-01

    This brief is designed for local staff of the Department of Veterans Affairs (VA), state McKinney-Vento coordinators and school district McKinney-Vento liaisons, educators, and other providers of services to active members of the military and veterans, and their children. It provides basic information to assist homeless children of veterans or…

  13. 5 CFR 1200.2 - Board members and duties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Board members and duties. 1200.2 Section 1200.2 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES BOARD ORGANIZATION General § 1200.2 Board members and duties. (a) The Board has three members whom the...

  14. 5 CFR 1200.2 - Board members and duties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Board members and duties. 1200.2 Section 1200.2 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES BOARD ORGANIZATION General § 1200.2 Board members and duties. (a) The Board has three members whom the...

  15. 5 CFR 1200.2 - Board members and duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Board members and duties. 1200.2 Section 1200.2 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES BOARD ORGANIZATION General § 1200.2 Board members and duties. (a) The Board has three members whom the...

  16. Achilles tendon ruptures stratified by age, race, and cause of injury among active duty U.S. Military members.

    PubMed

    Davis, J J; Mason, K T; Clark, D A

    1999-12-01

    A total of 865 members of the U.S. military underwent repair of Achilles tendon ruptures at U.S. military hospitals during calendar years 1994, 1995, and 1996. The discharge summaries of these patients were analyzed for patient demographic information, including age, race, and causative activity. Patients were then stratified by age, race, and cause of injury. Blacks were at increased risk for undergoing repair of the Achilles tendon compared with nonblacks (overall relative risk = 4.15, 95% confidence interval [CI] = 3.63, 4.74; summary odds ratio controlling for age = 3.69, CI = 3.25, 4.19). Participation in the game of basketball accounted for 64.9% of all injuries in black patients and 34.0% of all injuries in nonblack patients. Among those injured, blacks had a significantly increased risk for injury related to playing basketball than nonblacks (relative risk = 1.82, CI = 1.58, 2.10). This finding suggests that there may be other predisposing factor(s) that result in a higher risk of Achilles tendon ruptures in black individuals. PMID:10628159

  17. Development and testing of virtual reality exposure therapy for post-traumatic stress disorder in active duty service members who served in Iraq and Afghanistan.

    PubMed

    McLay, Robert N; Graap, Kenneth; Spira, James; Perlman, Karen; Johnston, Scott; Rothbaum, Barbara O; Difede, JoAnn; Deal, William; Oliver, David; Baird, Alicia; Bordnick, Patrick S; Spitalnick, Josh; Pyne, Jeffrey M; Rizzo, Albert

    2012-06-01

    This study was an open-label, single-group, treatment-development project aimed at developing and testing a method for applying virtual reality exposure therapy (VRET) to active duty service members diagnosed with combat post-traumatic stress disorder (PTSD). Forty-two service members with PTSD were enrolled, and 20 participants completed treatment. The PTSD Checklist-Military version, Patient Health Questionnaire-9 for depression, and the Beck Anxiety Inventory were used as outcome measures. Of those who completed post-treatment assessment, 75% had experienced at least a 50% reduction in PTSD symptoms and no longer met DSM-IV criteria for PTSD at post treatment. Average PSTD scores decreased by 50.4%, depression scores by 46.6%, and anxiety scores by 36%. Intention-to-treat analyses showed that statistically significant improvements in PTSD, depression, and anxiety occurred over the course of treatment and were maintained at follow up. There were no adverse events associated with VRET treatment. This study provides preliminary support for the use of VRET in combat-related PTSD. Further study will be needed to determine the wider utility of the method and to determine if it offers advantages over other established PTSD treatment modalities. PMID:22730837

  18. Impact of Transcendental Meditation on Psychotropic Medication Use Among Active Duty Military Service Members With Anxiety and PTSD.

    PubMed

    Barnes, Vernon A; Monto, Andrea; Williams, Jennifer J; Rigg, John L

    2016-01-01

    The purpose of the study was to determine whether the regular practice of Transcendental Meditation (TM) decreased the need for psychotropic medications required for anxiety and post-traumatic stress disorder (PTSD) management and increased psychological wellbeing. The sample included 74 military Service Members with documented PTSD or anxiety disorder not otherwise specified (ADNOS), 37 that practiced TM and 37 that did not. At 1 month, 83.7% of the TM group stabilized, decreased, or ceased medications and 10.8% increased medication dosage; compared with 59.4% of controls that showed stabilizations, decreases, or cessations; and 40.5% that increased medications (p < 0.03). A similar pattern was observed after 2 (p < 0.27), 3 (p < 0.002), and 6 months (p < 0.34). Notably, there was a 20.5% difference between groups in severity of psychological symptoms after 6 months, that is, the control group experienced an increase in symptom severity compared with the group practicing TM. These findings provide insight into the benefits of TM as a viable treatment modality in military treatment facilities for reducing PTSD and ADNOS psychological symptoms and associated medication use. PMID:26741477

  19. Voxel-wise resting-state MEG source magnitude imaging study reveals neurocircuitry abnormality in active-duty service members and veterans with PTSD

    PubMed Central

    Huang, Ming-Xiong; Yurgil, Kate A.; Robb, Ashley; Angeles, Annemarie; Diwakar, Mithun; Risbrough, Victoria B.; Nichols, Sharon L.; McLay, Robert; Theilmann, Rebecca J.; Song, Tao; Huang, Charles W.; Lee, Roland R.; Baker, Dewleen G.

    2014-01-01

    Post-traumatic stress disorder (PTSD) is a leading cause of sustained impairment, distress, and poor quality of life in military personnel, veterans, and civilians. Indirect functional neuroimaging studies using PET or fMRI with fear-related stimuli support a PTSD neurocircuitry model that includes amygdala, hippocampus, and ventromedial prefrontal cortex (vmPFC). However, it is not clear if this model can fully account for PTSD abnormalities detected directly by electromagnetic-based source imaging techniques in resting-state. The present study examined resting-state magnetoencephalography (MEG) signals in 25 active-duty service members and veterans with PTSD and 30 healthy volunteers. In contrast to the healthy volunteers, individuals with PTSD showed: 1) hyperactivity from amygdala, hippocampus, posterolateral orbitofrontal cortex (OFC), dorsomedial prefrontal cortex (dmPFC), and insular cortex in high-frequency (i.e., beta, gamma, and high-gamma) bands; 2) hypoactivity from vmPFC, Frontal Pole (FP), and dorsolateral prefrontal cortex (dlPFC) in high-frequency bands; 3) extensive hypoactivity from dlPFC, FP, anterior temporal lobes, precuneous cortex, and sensorimotor cortex in alpha and low-frequency bands; and 4) in individuals with PTSD, MEG activity in the left amygdala and posterolateral OFC correlated positively with PTSD symptom scores, whereas MEG activity in vmPFC and precuneous correlated negatively with symptom score. The present study showed that MEG source imaging technique revealed new abnormalities in the resting-state electromagnetic signals from the PTSD neurocircuitry. Particularly, posterolateral OFC and precuneous may play important roles in the PTSD neurocircuitry model. PMID:25180160

  20. 77 FR 28763 - Flightcrew Member Duty and Rest Requirements; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    .... DATES: The effective date for the rule published January 4, 2012, at 77 FR 330, is corrected to January... final rule entitled, ``Flightcrew Member Duty and Rest Requirements'' (77 FR 330). In that rule, the FAA... time, and that a longer effective date is unwarranted'' (77 FR 392). Because the final rule...

  1. 77 FR 73911 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... Register as Flight Crew Member Duty and Rest Requirements on January 4, 2012. 77 FR 330. The regulations... http://www.gpoaccess.gov/fr/index.html . Alternatively, a copy may be requested directly from the FAA... calculation errors present in that document, and presents sensitivity analysis on key assumptions used in...

  2. 75 FR 55851 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... proceeding with a final rule.\\3\\ \\1\\ 57 FR 26685; June 15, 1992. \\2\\ Flightcrew Member Duty Period Limitations, Flight Time Limitations and Rest Requirements notice of proposed rulemaking (60 FR 65951; December 20, 1995). \\3\\ 74 FR 61067. On June 10, 2009, Federal Aviation Administration (FAA)...

  3. The Impact of Environment and Occupation on the Health and Safety of Active Duty Air Force Members: Database Development and De-Identification.

    PubMed

    Erich, Roger; Eaton, Melinda; Mayes, Ryan; Pierce, Lamar; Knight, Andrew; Genovesi, Paul; Escobar, James; Mychalczuk, George; Selent, Monica

    2016-08-01

    Preparing data for medical research can be challenging, detail oriented, and time consuming. Transcription errors, missing or nonsensical data, and records not applicable to the study population may hamper progress and, if unaddressed, can lead to erroneous conclusions. In addition, study data may be housed in multiple disparate databases and complex formats. Merging methods may be incomplete to obtain temporally synchronized data elements. We created a comprehensive database to explore the general hypothesis that environmental and occupational factors influence health outcomes and risk-taking behavior among active duty Air Force personnel. Several databases containing demographics, medical records, health survey responses, and safety incident reports were cleaned, validated, and linked to form a comprehensive, relational database. The final step involved removing and transforming personally identifiable information to form a Health Insurance Portability and Accountability Act compliant limited database. Initial data consisted of over 62.8 million records containing 221 variables. When completed, approximately 23.9 million clean and valid records with 214 variables remained. With a clean, robust database, future analysis aims to identify high-risk career fields for targeted interventions or uncover potential protective factors in low-risk career fields. PMID:27483519

  4. Civilian Health and Medical Program of the Uniformed Services (CHAMPUS); TRICARE uniform health maintenance organization (HMO) benefit--Prime enrollment fee exemption for survivors of active duty deceased sponsors and medically retired uniformed services members and their dependents. Final rule.

    PubMed

    2014-09-30

    This final rule creates an exception to the usual rule that TRICARE Prime enrollment fees are uniform for all retirees and their dependents and responds to public comments received to the proposed rule published in the Federal Register on June 7, 2013. Survivors of Active Duty Deceased Sponsors and Medically Retired Uniformed Services Members and their Dependents are part of the retiree group under TRICARE rules. In acknowledgment and appreciation of the sacrifices of these two beneficiary categories, the Secretary of Defense has elected to exercise his authority under the United States Code to exempt Active Duty Deceased Sponsors and Medically Retired Uniformed Services Members and their Dependents enrolled in TRICARE Prime from paying future increases to the TRICARE Prime annual enrollment fees. The Prime beneficiaries in these categories have made significant sacrifices for our country and are entitled to special recognition and benefits for their sacrifices. Therefore, the beneficiaries in these two TRICARE beneficiary categories who enrolled in TRICARE Prime prior to 10/1/2013, and those since that date, will have their annual enrollment fee frozen at the appropriate fiscal year rate: FY2011 rate $230 per single or $460 per family, FY2012 rate $260 or $520, FY2013 rate $269.38 or $538.56, or the FY2014 rate $273.84 or $547.68. The future beneficiaries added to these categories will have their fee frozen at the rate in effect at the time they are classified in either category and enroll in TRICARE Prime or, if not enrolling, at the rate in effect at the time of enrollment. The fee remains frozen as long as at least one family member remains enrolled in TRICARE Prime and there is not a break in enrollment. The fee charged for the dependent(s) of a Medically Retired Uniformed Services Member would not change if the dependent(s) was later re-classified a Survivor. PMID:25269153

  5. Increasing Marital Satisfaction as a Resilience Factor among Active Duty Members and Veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF)

    ERIC Educational Resources Information Center

    Ponder, Warren N.; Aguirre, Regina T. P.; Smith-Osborne, Alexa; Granvold, Donald K.

    2012-01-01

    Supportive relationships are protective against a number of prevalent health risks among military populations, including post-traumatic stress disorder. Increasing marital satisfaction and strengthening that relationship is an important avenue for maintaining health among returning service members and their families. The current study builds upon…

  6. Overview of depression, post-traumatic stress disorder, and alcohol misuse among active duty service members returning from Iraq and Afghanistan, self-report and diagnosis.

    PubMed

    Mustillo, Sarah A; Kysar-Moon, Ashleigh; Douglas, Susan R; Hargraves, Ryan; Wadsworth, Shelley MacDermid; Fraine, Melissa; Frazer, Nicole L

    2015-04-01

    Previous studies have found deployment to combat areas to be associated with an increased risk of post-traumatic stress disorder (PTSD), depression, and alcohol abuse, but many previous studies were limited by samples that were not representative of the deployed military as a whole. This study presents an overview of these three mental health problems associated with deployment among Air Force, Army, Marine Corp, and Navy service members returning from deployment to Iraq and Afghanistan between January 2007 and March 2008. With postdeployment health data on over 50,000 service men and women, including diagnostic information, we were able to estimate prevalence of those who screened positive for risk of each disorder in self-report data at two time points, as well as prevalence of diagnoses received during health care encounters within the military health care system. The prevalence ranges of the three disorders were consistent with previous studies using similar measures, but service members in the Navy had higher rates of screening positive for all three disorders and higher prevalence of depression and PTSD diagnoses compared to the other branches. Further, PTSD risk was higher for service members returning from Afghanistan compared to Iraq, in contrast to previous findings. PMID:25826347

  7. A randomized, controlled trial of virtual reality-graded exposure therapy for post-traumatic stress disorder in active duty service members with combat-related post-traumatic stress disorder.

    PubMed

    McLay, Robert N; Wood, Dennis P; Webb-Murphy, Jennifer A; Spira, James L; Wiederhold, Mark D; Pyne, Jeffrey M; Wiederhold, Brenda K

    2011-04-01

    Abstract Virtual reality (VR)-based therapy has emerged as a potentially useful means to treat post-traumatic stress disorder (PTSD), but randomized studies have been lacking for Service Members from Iraq or Afghanistan. This study documents a small, randomized, controlled trial of VR-graded exposure therapy (VR-GET) versus treatment as usual (TAU) for PTSD in Active Duty military personnel with combat-related PTSD. Success was gauged according to whether treatment resulted in a 30 percent or greater improvement in the PTSD symptom severity as assessed by the Clinician Administered PTSD Scale (CAPS) after 10 weeks of treatment. Seven of 10 participants improved by 30 percent or greater while in VR-GET, whereas only 1 of the 9 returning participants in TAU showed similar improvement. This is a clinically and statistically significant result (χ(2) = 6.74, p < 0.01, relative risk 3.2). Participants in VR-GET improved an average of 35 points on the CAPS, whereas those in TAU averaged a 9-point improvement (p < 0.05). The results are limited by small size, lack of blinding, a single therapist, and comparison to a relatively uncontrolled usual care condition, but did show VR-GET to be a safe and effective treatment for combat-related PTSD. PMID:21332375

  8. Unintended Pregnancy and Contraception Among Active Duty Servicewomen and Veterans

    PubMed Central

    Goyal, Vinita; Borrero, Sonya; Schwarz, Eleanor Bimla

    2012-01-01

    The number of women of childbearing age who are active duty service members or veterans of the U.S. military is increasing. These women may seek reproductive health care at medical facilities operated by the military, in the civilian sector or through the Department of Veterans Affairs. This article reviews the current data on unintended pregnancy and prevalence of and barriers to contraceptive use among active duty and veteran women. Active duty servicewomen have high rates of unintended pregnancy and low contraceptive use which may be due to official prohibition of sexual activity in the military, logistic difficulties faced by deployed women and limited patient and provider knowledge of available contraceptives. In comparison, little is known about rates of unintended pregnancy and contraceptive use among women veterans. Based on this review, research recommendations to address these issues are provided. PMID:22200252

  9. 16 CFR 613.1 - Duration of active duty alerts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Duration of active duty alerts. 613.1 Section 613.1 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT DURATION OF ACTIVE DUTY ALERTS § 613.1 Duration of active duty alerts. The duration of an active duty alert shall...

  10. 16 CFR 613.1 - Duration of active duty alerts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Duration of active duty alerts. 613.1 Section 613.1 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT DURATION OF ACTIVE DUTY ALERTS § 613.1 Duration of active duty alerts. The duration of an active duty alert shall...

  11. 16 CFR 613.1 - Duration of active duty alerts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Duration of active duty alerts. 613.1 Section 613.1 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT DURATION OF ACTIVE DUTY ALERTS § 613.1 Duration of active duty alerts. The duration of an active duty alert shall...

  12. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military duty...-time active military duty after a loan is closed not exceed six percent. Active military duty does...

  13. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military duty...-time active military duty after a loan is closed not exceed six percent. Active military duty does...

  14. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military duty...-time active military duty after a loan is closed not exceed six percent. Active military duty does...

  15. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military duty...-time active military duty after a loan is closed not exceed six percent. Active military duty does...

  16. 7 CFR 3550.158 - Active military duty.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military duty...-time active military duty after a loan is closed not exceed six percent. Active military duty does...

  17. 78 FR 11090 - Flightcrew Member Duty and Rest Requirements; Technical Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Member Duty and Rest Requirements'' (77 FR 330). In that rule, the FAA created a new part, part 117... rule correction published in the Federal Register of February 6, 2013 (78 FR 8361), is corrected from... correction on February 6, 2013 (78 FR 8361). The FAA realized that the effective date in this rule...

  18. 77 FR 40790 - Flightcrew Member Duty and Rest Requirements; OMB Approval of Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... and Rest Requirements'' was published in the Federal Register (77 FR 330). In that rule, the FAA... 4, 2012. DATES: The rule published January 4, 2012 (77 FR 330), including the information collection... TRANSPORTATION Federal Aviation Administration 14 CFR Part 117 RIN 2120-AJ58 Flightcrew Member Duty and...

  19. 12 CFR 1022.121 - Active duty alerts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Active duty alerts. 1022.121 Section 1022.121... Consumer Reporting Agencies Regarding Identity Theft § 1022.121 Active duty alerts. (a) Duration. The duration of an active duty alert shall be twelve months. (b)...

  20. 12 CFR 1022.121 - Active duty alerts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Active duty alerts. 1022.121 Section 1022.121... Consumer Reporting Agencies Regarding Identity Theft § 1022.121 Active duty alerts. (a) Duration. The duration of an active duty alert shall be twelve months....

  1. 12 CFR 1022.121 - Active duty alerts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Active duty alerts. 1022.121 Section 1022.121... Consumer Reporting Agencies Regarding Identity Theft § 1022.121 Active duty alerts. (a) Duration. The duration of an active duty alert shall be twelve months....

  2. Outcomes of biceps tenodesis in an active duty population.

    PubMed

    Jacobs, Jeremy M; Jackson, Keith L; Pniewski, Josh E; Dickston, Michelle L; Abell, Brian E; Mueller, Terry L; Bojescul, John A

    2015-01-01

    Pathology affecting the long head of the biceps tendon and its insertion is a frequent cause of shoulder pain in the active duty military population. The purpose of this investigation was to evaluate functional outcomes of subpectoral biceps tenodesis in an active duty population. A retrospective case series of 22 service members who underwent biceps tenodesis was performed and Shoulder Pain and Disability Indexes (SPADI) and Disabilities of the Arm, Shoulder and Hand (DASH) scores were obtained preoperatively and at 6 months. Additionally, a review of each subject's physical profile was performed 6 months after surgery to determine continued physical limitations and one's ability to deploy. There was a statistically significant improvement in SPADI and DASH scores comparing preoperative versus postoperative outcomes. Although five subjects (22%) continued to have a restriction to performing push-ups on the Army Physical Fitness Test, all were deemed deployable from a physical standpoint. The results of this review suggest that active duty personnel undergoing biceps tenodesis have significant functional improvement at 6 months. Additionally, very few have long-term physical limitations or deployment restrictions. PMID:25988691

  3. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  4. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  5. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  6. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  7. 22 CFR 19.11-6 - Death during active duty.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Death during active duty. 19.11-6 Section 19.11... PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.11-6 Death during active duty. (a...-2 computed as if the participant had retired on the date of death unless a court order or...

  8. 78 FR 63459 - Notice of Active Duty Determination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... Department of the Air Force Notice of Active Duty Determination AGENCY: Department of the Air Force, DoD. ACTION: Proposed Federal Register Notice of Active Duty Determination Under Public Law 95-202. SUMMARY: On September 30, 2013, the Secretary of the Air Force, acting as Executive Agent of the Secretary...

  9. Chronic pain management in the active-duty military

    NASA Astrophysics Data System (ADS)

    Jamison, David; Cohen, Steven P.

    2012-06-01

    As in the general population, chronic pain is a prevalent and burdensome affliction in active-duty military personnel. Painful conditions in military members can be categorized broadly in terms of whether they arise directly from combat injuries (gunshot, fragmentation wound, blast impact) or whether they result from non-combat injuries (sprains, herniated discs, motor vehicle accidents). Both combat-related and non-combat-related causes of pain can further be classified as either acute or chronic. Here we discuss the state of pain management as it relates to the military population in both deployed and non-deployed settings. The term non-battle injury (NBI) is commonly used to refer to those conditions not directly associated with the combat actions of war. In the history of warfare, NBI have far outstripped battle-related injuries in terms not only of morbidity, but also mortality. It was not until improvements in health care and field medicine were applied in World War I that battle-related deaths finally outnumbered those attributed to disease and pestilence. However, NBI have been the leading cause of morbidity and hospital admission in every major conflict since the Korean War. Pain remains a leading cause of presentation to military medical facilities, both in and out of theater. The absence of pain services is associated with a low return-to-duty rate among the deployed population. The most common pain complaints involve the low-back and neck, and studies have suggested that earlier treatment is associated with more significant improvement and a higher return to duty rate. It is recognized that military medicine is often at the forefront of medical innovation, and that many fields of medicine have reaped benefit from the conduct of war.

  10. 38 CFR 3.12a - Minimum active-duty service requirement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Minimum active-duty... Minimum active-duty service requirement. (a) Definitions. (1) The term minimum period of active duty means... continuous active duty. Non-duty periods that are excludable in determining the Department of...

  11. Unintended pregnancy and contraception among active-duty servicewomen and veterans.

    PubMed

    Goyal, Vinita; Borrero, Sonya; Schwarz, Eleanor Bimla

    2012-06-01

    The number of women of childbearing age who are active-duty service members or veterans of the US military is increasing. These women may seek reproductive health care at medical facilities operated by the military, in the civilian sector, or through the Department of Veterans Affairs. This article reviews the current data on unintended pregnancy and prevalence of and barriers to contraceptive use among active-duty and veteran women. Active-duty servicewomen have high rates of unintended pregnancy and low contraceptive use, which may be due to official prohibition of sexual activity in the military, logistic difficulties faced by deployed women, and limited patient and provider knowledge of available contraceptives. In comparison, little is known about rates of unintended pregnancy and contraceptive use among women veterans. Based on this review, research recommendations to address these issues are provided. PMID:22200252

  12. Effectiveness of virtual reality exposure therapy for active duty soldiers in a military mental health clinic.

    PubMed

    Reger, Greg M; Holloway, Kevin M; Candy, Colette; Rothbaum, Barbara O; Difede, JoAnn; Rizzo, Albert A; Gahm, Gregory A

    2011-02-01

    Exposure therapy is an evidence-based treatment for posttraumatic stress disorder (PTSD), but research evaluating its effectiveness with active duty service members is limited. This report examines the effectiveness of virtual reality exposure therapy (VRE) for active duty soldiers (N = 24) seeking treatment following a deployment to Iraq or Afghanistan. Relative to their pretreatment self-reported symptoms on the PTSD Checklist, Military Version (M = 60.92; SD = 11.03), patients reported a significant reduction at posttreatment (M = 47.08; SD = 12.70; p < .001). Sixty-two percent of patients (n = 15) reported a reliable change of 11 points or more. This study supports the effectiveness of exposure therapy for active duty soldiers and extends previous research on VRE to this population. PMID:21294166

  13. Active-member control of precision structures

    NASA Technical Reports Server (NTRS)

    Fanson, J. L.; Blackwood, G. H.; Chu, C. C.

    1989-01-01

    This paper presents the results of closed loop experiments that use piezoelectric active-members to control the flexible motion of a precision truss structure. These experiments are directed toward the development of high performance structural systems as part of the Control/Structure Interaction program at JPL. Order of magnitude reductions in dynamic response are achieved with relatively simple control techniques. The practical implementation of high stiffness, high bandwidth active-members in a precision structure highlights specific issues of importance relating to the modelling and implementation of active-member control.

  14. Treatment of active duty military with PTSD in primary care: A follow-up report.

    PubMed

    Cigrang, Jeffrey A; Rauch, Sheila A M; Mintz, Jim; Brundige, Antoinette; Avila, Laura L; Bryan, Craig J; Goodie, Jeffrey L; Peterson, Alan L

    2015-12-01

    First-line trauma-focused therapies offered in specialty mental health clinics do not reach many veterans and active duty service members with posttraumatic stress disorder (PTSD). Primary care is an ideal environment to expand access to mental health care. Several promising clinical case series reports of brief PTSD therapies adapted for primary care have shown positive results, but the long-term effectiveness with military members is unknown. The purpose of this study was to determine the long-term outcome of an open trial of a brief cognitive-behavioral primary care-delivered protocol developed specifically for deployment-related PTSD in a sample of 24 active duty military (15 men, 9 women). Measures of PTSD symptom severity showed statistically and clinically significant reductions from baseline to posttreatment that were maintained at the 6-month and 1-year follow-up assessments. Similar reductions were maintained in depressive symptoms and ratings of global mental health functioning. PMID:26519833

  15. Prevalence of Perceived Stress and Mental Health Indicators Among Reserve-Component and Active-Duty Military Personnel

    PubMed Central

    Lane, Marian E.; Hourani, Laurel L.; Bray, Robert M.; Williams, Jason

    2012-01-01

    Objectives. We examined stress levels and other indicators of mental health in reservists and active-duty military personnel by deployment status. Methods. We used data from the Department of Defense Health-Related Behaviors surveys, which collect comprehensive, population-based data for reserve and active-duty forces. Data were collected from 18 342 reservists and 16 146 active-duty personnel. Results. Overall, with adjustment for sociodemographic and service differences, reservists reported similar or less work and family stress, depression, and anxiety symptoms than did active-duty personnel. However, reservists who had been deployed reported higher rates of suicidal ideation and attempts than did active-duty personnel who had been deployed and higher rates of post-traumatic stress disorder symptomatology than did any active-duty personnel and reservists who had not been deployed. The highest rates of suicidal ideation and attempts were among reservists who had served in theaters other than Iraq and Afghanistan. Conclusions. Our results suggest that deployment has a greater impact on reservists than on active-duty members, thus highlighting the urgent need for services addressing reservists’ unique postdeployment mental health issues. Also, deployment to any theater, not only Iraq or Afghanistan, represents unique threats to all service members’ mental well-being. PMID:22571709

  16. Estimated economic impact of the levonorgestrel intrauterine system on unintended pregnancy in active duty women.

    PubMed

    Heitmann, Ryan J; Mumford, Sunni L; Hill, Micah J; Armstrong, Alicia Y

    2014-10-01

    Unintended pregnancy is reportedly higher in active duty women; therefore, we sought to estimate the potential impact of the levonorgestrel-containing intrauterine system (LNG-IUS) could have on unintended pregnancy in active duty women. A decision tree model with sensitivity analysis was used to estimate the number of unintentional pregnancies in active duty women which could be prevented. A secondary cost analysis was performed to analyze the direct cost savings to the U.S. Government. The total number of Armed Services members is estimated to be over 1.3 million, with an estimated 208,146 being women. Assuming an age-standardized unintended pregnancy rate of 78 per 1,000 women, 16,235 unintended pregnancies occur each year. Using a combined LNG-IUS failure and expulsion rate of 2.2%, a decrease of 794, 1588, and 3970 unintended pregnancies was estimated to occur with 5%, 10% and 25% usage, respectively. Annual cost savings from LNG-IUS use range from $3,387,107 to $47,352,295 with 5% to 25% intrauterine device usage. One-way sensitivity analysis demonstrated LNG-IUS to be cost-effective when the cost associated with pregnancy and delivery exceeded $11,000. Use of LNG-IUS could result in significant reductions in unintended pregnancy among active duty women, resulting in substantial cost savings to the government health care system. PMID:25269131

  17. 29 CFR 1960.58 - Training of collateral duty safety and health personnel and committee members.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Training of collateral duty safety and health personnel and... SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) BASIC PROGRAM ELEMENTS FOR FEDERAL EMPLOYEE OCCUPATIONAL SAFETY AND HEALTH PROGRAMS AND RELATED MATTERS Training § 1960.58 Training...

  18. 78 FR 69287 - Flightcrew Member Duty and Rest Requirements; Technical Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... Duty and Rest Requirements Final Rule, 77 FR 330, 336-337 (Jan. 4, 2012). \\2\\ Id. at 403 (emphasis... Requirements'' (77 FR 330). In that rule, the FAA created a new part, part 117, which replaced the then... of Tables A/B/C or Sec. 117.23. Accordingly, in the final rule, FR Doc. 2011-33078, published...

  19. 78 FR 8361 - Flightcrew Member Duty and Rest Requirements; Technical Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Requirements'' (77 FR 330). In that rule, the FAA created a new part, part 117, which replaced the then... reserve to have the same extension as a flight duty period. Accordingly, in the final rule, FR Doc. 2011-33078, published on January 4, 2012 (77 FR 330), make the following corrections: Sec. 117.11 0 1....

  20. [Conditioning of community nurse duties towards the patient treated by family doctor--the opinion of family doctor staff members].

    PubMed

    Rogala-Pawelczyk, Grazyna

    2002-01-01

    The team of family doctor is the main link in the basic health care. It consists of community nurses who work according to the plan specifying the health needs of patients. Community nurses fulfil the needs of patients of various age and health conditions. The paper presents a part of studies on the area and activities of community nurses working in the team of family doctor. An attempt was made to answer the following questions: what are the duties of community nurse, what factors make it easy to fulfil the duties and what factors make the work more difficult? The study comprised a few dozen of community nurses and family doctors all over the country. It was carried out from January to April 2001. Two questionnaires were used for community nurses and for family doctors. Medical documentation was also analysed. It gave answers to problem questions: duties of community nurses include: co-operation in diagnosing and treatment, health promotion and education, fulfilment of therapeutic and nursing programme, factors which help to realise the programme include: qualifications, clearly stated duties, equipment, factors which make the work difficult comprise: lack of staff, poor salary, legislation problems, difficulties in self-development, lack of co-operation from patients and their families. No differences in the opinion of both groups on the duties of community nurses were noticed. PMID:17474614

  1. Lesions Arising in a Tattoo of an Active Duty US Marine Corps Woman.

    PubMed

    Winn, Aubrey E; Rivard, Shayna C; Green, Brian

    2016-01-01

    Tattoos are ubiquitous in modern society; however, they do not come without risk of medical complications. When complications arise in the military community, a particularly thorough differential diagnosis should be considered based on the increased exposures service members have during deployment and throughout their military career. We present a case of a 38-year-old active duty US Marine Corps woman with worsening skin lesions arising within a tattoo 6 weeks after acquiring the tattoo on her right chest. Given environmental exposures from a recent deployment to the Middle East, a wide differential was considered. Ultimately, a skin biopsy revealed early hypertrophic scar formation responsive to therapy with intralesional triamcinolone acetonide (Kenalog® [ILK]). However, given the Marine had recently deployed and is part of the active duty population, consideration of alternative, albeit rare, etiologies was imperative. PMID:27450611

  2. Caring for Active Duty Military Personnel in the Civilian Sector

    PubMed Central

    Waitzkin, Howard; Noble, Marylou

    2011-01-01

    Due to the wars in Iraq and Afghanistan, the unmet medical and psychological needs of military personnel are creating major challenges. Increasingly, active duty military personnel are seeking physical and mental health services from civilian professionals. The Civilian Medical Resources Network attempts to address these unmet needs. Participants in the Network include primary care and mental health practitioners in all regions of the country. Network professionals provide independent assessments, clinical interventions in acute situations, and documentation that assists GIs in obtaining reassignment or discharge. Most clients who use Network services come from low-income backgrounds and manifest psychological rather than physical disorders. Qualitative themes in professional-client encounters have focused on ethical conflicts, the impact of violence without meaning (especially violence against civilians), and perceived problems in military health and mental health policies. Unmet needs of active duty military personnel deserve more concerted attention from medical professionals and policy makers. PMID:21339846

  3. Virtual reality exposure therapy for active duty soldiers.

    PubMed

    Reger, Greg M; Gahm, Gregory A

    2008-08-01

    Virtual reality exposure (VRE) therapy is a promising treatment for a variety of anxiety disorders and has recently been extended to the treatment of posttraumatic stress disorder (PTSD). In this article, the authors briefly review the rationale for VRE and its key processes. They illustrate the treatment with an active-duty Army soldier diagnosed with combat-related PTSD. Six sessions of VRE were provided using an immersive simulation of a military convoy in Iraq. Self-reported PTSD symptoms and psychological distress were reduced at posttreatment relative to pretreatment reports, as assessed by the PTSD Checklist-Military Version and the Behavior and Symptom Identification Scale-24. The case outcomes parallel those reported in the research with other disorders and suggest the applicability of VRE in treating active duty soldiers with combat-related PTSD. PMID:18612993

  4. Returning service members to duty following mild traumatic brain injury: exploring the use of dual-task and multitask assessment methods.

    PubMed

    Scherer, Matthew R; Weightman, Margaret M; Radomski, Mary V; Davidson, Leslie F; McCulloch, Karen L

    2013-09-01

    Within the last decade, more than 220,000 service members have sustained traumatic brain injury (TBI) in support of military operations in Iraq and Afghanistan. Mild TBI may result in subtle cognitive and sensorimotor deficits that adversely affect warfighter performance, creating significant challenges for service members, commanders, and clinicians. In recent conflicts, physical therapists and occupational therapists have played an important role in evaluating service member readiness to return to duty (RTD), incorporating research and best practices from the sports concussion literature. Because premorbid (baseline) performance metrics are not typically available for deployed service members as for athletes, clinicians commonly determine duty readiness based upon the absence of postconcussive symptoms and return to "normal" performance on clinical assessments not yet validated in the military population. Although practices described in the sports concussion literature guide "return-to-play" determinations, resolution of symptoms or improvement of isolated impairments may be inadequate to predict readiness in a military operational environment. Existing clinical metrics informing RTD decision making are limited because they fail to emphasize functional, warrior task demands and they lack versatility to assess the effects of comorbid deficits. Recently, a number of complex task-oriented RTD approaches have emerged from Department of Defense laboratory and clinical settings to address this gap. Immersive virtual reality environments, field-based scenario-driven assessment programs, and militarized dual-task and multitask-based approaches have all been proposed for the evaluation of sensorimotor and cognitive function following TBI. There remains a need for clinically feasible assessment methods that can be used to verify functional performance and operational competence in a variety of practice settings. Complex and ecologically valid assessment techniques

  5. Army Active Duty Members’ Linkage to Veterans Health Administration Services After Deployments to Iraq or Afghanistan and Following Separation

    PubMed Central

    Vanneman, Megan E.; Harris, Alex H. S.; Chen, Cheng; Mohr, Beth A.; Adams, Rachel Sayko; Williams, Thomas V.; Larson, Mary Jo

    2015-01-01

    This study described the rate and predictors of Operation Enduring Freedom/Operation Iraqi Freedom active duty Army members’ enrollment in and use of Veterans Health Administration (VHA) services (linkage), as well as variation in linkage rates by VHA facility. We used a multivariate mixed effect regression model to predict linkage to VHA, and also calculated linkage rates in the catchment areas of each facility (n = 158). The sample included 151,122 active duty members who deployed to Iraq or Afghanistan and then separated from the Army between fiscal years 2008 and 2012. Approximately 48% of the active duty members separating utilized VHA as an enrollee within one year. There was significant variation in linkage rates by VHA facilities (31–72%). The most notable variables associated with greater linkage included probable serious injury during index deployment (odds ratio = 1.81), separation because of disability (odds ratio = 2.86), and various measures of receipt of VHA care before and after separation. Information about the individual characteristics that predict greater or lesser linkage to VHA services can be used to improve delivery of health care services at VHA as well as outreach efforts to active duty Army members. PMID:26444467

  6. Parasuicidal behavior on an active duty army training post.

    PubMed

    Koshes, R J; Rothberg, J M

    1992-07-01

    The incidence of suicidal behavior among active duty Army personnel at a training post has not been the subject of analysis since the advent of the all-volunteer military. A review of admissions over 16 consecutive months showed most of the behaviors to be parasuicidal, with low levels of lethality and high rescuability. Compared to previously published studies, the characteristics of these soldiers are little changed over the past 25 years. This report suggests a standard method for handling suicidal behavior which includes an active role for psychiatric consultation to units and commanders. PMID:1528469

  7. Access to mental health services for active duty and National Guard TRICARE enrollees in Indiana.

    PubMed

    Avery, George H; Wadsworth, Shelley M MacDermid

    2011-03-01

    Mental health problems are a well-known consequence of combat exposure, and the problem of barriers to receiving mental health care for veterans is well known. The current heavy reliance on reserve component soldiers may aggravate this problem. This study tries to characterize problems with access to mental health care for activated members of the National Guard reserve component, active duty service members, and their families in the state of Indiana. Data from a telephone survey of Indiana mental health providers listed in the TRICARE provider revealed that only 25% were accepting new TRICARE patients, although regression analyses revealed that acceptance of patients was positively related to market population and negatively related to the number of deployed soldiers in the market. The primary barrier to obtain care appears to be the accuracy of the TRICARE provider list. PMID:21456350

  8. Participation of VICA Members in Personal Development Activities.

    ERIC Educational Resources Information Center

    Gordon, Howard R. D.

    A study examined the extent to which 1994-95 members of the West Virginia chapter of Vocational Industrial Clubs of America (VICA) participated in VICA personal development activities. The study population consisted of all VICA members in West Virginia, and the study sample consisted of all 156 VICA members who attended the annual West Virginia…

  9. Decision-Making Styles of Active-Duty Police Officers: A Multiple-Case Occupational Study

    ERIC Educational Resources Information Center

    Calhoun, Patrick Wayne

    2013-01-01

    Little is known about the decision-making styles of active-duty police officers or what the consequences of not understanding those decision-making styles may be. The purpose of the study was to describe the demographics and decision-making profiles of active-duty police officers, as well as any relationships that may exist among these variables,…

  10. Factors influencing perceived need for dental care by active duty U.S. military personnel.

    PubMed

    Chisick, M C; Poindexter, F R; York, A K

    1997-09-01

    This study explores factors that influence perceived need for dental care among active duty U.S. military personnel. The data were collected on a prestratified random sample of 12,950 (76% response rate) service members between April 1994 and January 1995. Participants received a comprehensive oral examination from a dentist and answered queries concerning perceived need on self-administered questionnaires. Using bivariate and logistic regression analyses, we examined the association between demographic and clinical measures and perceived need for dental care. Bivariate results show that half of all U.S. military personnel perceive a need for dental care, with statistically significant differences across race, rank, education, branch of service, dental health class, and dental utilization. Logistic regression results show that the likelihood of perceived need is influenced by age, race, rank, branch of service, dental disease, dental health class, and dental utilization. Extensive dental decay is the strongest predictor of perceived need in this population. PMID:9290291

  11. Incidence of Norovirus-Associated Medical Encounters among Active Duty United States Military Personnel and Their Dependents

    PubMed Central

    Rha, Brian; Lopman, Benjamin A.; Alcala, Ashley N.; Riddle, Mark S.; Porter, Chad K.

    2016-01-01

    Background Norovirus is a leading cause of gastroenteritis episodes and outbreaks in US military deployments, but estimates of endemic disease burden among military personnel in garrison are lacking. Methods Diagnostic codes from gastroenteritis-associated medical encounters of active duty military personnel and their beneficiaries from July 1998–June 2011 were obtained from the Armed Forces Health Surveillance Center. Using time-series regression models, cause-unspecified encounters were modeled as a function of encounters for specific enteropathogens. Model residuals (representing unexplained encounters) were used to estimate norovirus-attributable medical encounters. Incidence rates were calculated using population data for both active duty and beneficiary populations. Results The estimated annual mean rate of norovirus-associated medically-attended visits among active duty personnel and their beneficiaries was 292 (95% CI: 258 to 326) and 93 (95% CI: 80 to 105) encounters per 10,000 persons, respectively. Rates were highest among beneficiaries <5 years of age with a median annual rate of 435 (range: 318 to 646) encounters per 10,000 children. Norovirus was estimated to cause 31% and 27% of all-cause gastroenteritis encounters in the active duty and beneficiary populations, respectively, with over 60% occurring between November and April. There was no evidence of any lag effect where norovirus disease occurred in one population before the other, or in one beneficiary age group before the others. Conclusions Norovirus is a major cause of medically-attended gastroenteritis among non-deployed US military active duty members as well as in their beneficiaries. PMID:27115602

  12. Advanced Marketing 8130. Instructional Areas. Duties and Tasks. Learning Activities. Referenced Resources.

    ERIC Educational Resources Information Center

    Virginia State Dept. of Education, Richmond.

    This resource handbook, which is designed for use by instructors of courses in advanced marketing, consists of a duty/task list with referenced resources, a duty/task list with learning activities, and a list of resources. Included in each list are materials dealing with the following topics: communication in marketing, economics in marketing,…

  13. NASA Elementary Aerospace Activities Free to Members

    ERIC Educational Resources Information Center

    Journal of Aerospace Education, 1978

    1978-01-01

    Describes the contents of Elementary School Aerospace Activities: A Resource for Teachers. Activities examine a variety of topics in aerospace education and are intended to be used with children ages 5-11. The book is available from the Government Printing Office (GPO) for $3.00. (CP)

  14. 38 CFR 17.31 - Duty periods defined.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Definitions and Active Duty § 17.31 Duty periods defined. Full-time duty as a member of the Women's Army Auxiliary Corps, Women's Reserve of the Navy and Marine Corps and Women's Reserve of the Coast Guard... Patient Rights...

  15. Hospitalizations for fall-related injuries among active-duty Army soldiers, 1980–1998

    PubMed Central

    Senier, Laura; Bell, Nicole S.; Yore, Michelle M.; Amoroso, Paul J.

    2007-01-01

    Data from the Total Army Injury and Health Outcomes Database (TAIHOD) were used to describe 28,352 fall-related hospitalizations among active-duty Army soldiers between 1980 and 1998. Soldiers who were younger than age 26, single, and had a high school education or less were at greatest risk. Falls from a height were more likely to be fatal than other types of falls, accounting for 88% of all fatalities. In cases where duty status was known, 64% of the falls took place while the soldier was on duty and half of these occurred during training. The most common type of fall during training was fall from a height (37%). Falls on stairs and ladders accounted for 49% of all off-duty falls. Future research should include identification of specific behavioral and occupational risk factors for falls, particularly those occurring during training activities, and falls occurring off duty. PMID:12441580

  16. Development of magnetostrictive active members for control of space structures

    NASA Technical Reports Server (NTRS)

    Johnson, Bruce G.; Avakian, Kevin M.; Fenn, Ralph C.; Gaffney, Monique S.; Gerver, Michael J.; Hawkey, Timothy J.; Boudreau, Donald J.

    1992-01-01

    The goal of this Phase 2 Small Business Innovative Research (SBIR) project was to determine the technical feasibility of developing magnetostrictive active members for use as truss elements in space structures. Active members control elastic vibrations of truss-based space structures and integrate the functions of truss structure element, actively controlled actuator, and sensor. The active members must control structural motion to the sub-micron level and, for many proposed space applications, work at cryogenic temperatures. Under this program both room temperature and cryogenic temperature magnetostrictive active members were designed, fabricated, and tested. The results of these performance tests indicated that room temperature magnetostrictive actuators feature higher strain, stiffness, and force capability with lower amplifier requirements than similarly sized piezoelectric or electrostrictive active members, at the cost of higher mass. Two different cryogenic temperature magnetostrictive materials were tested at liquid nitrogen temperatures, both with larger strain capability than the room temperature magnetostrictive materials. The cryogenic active member development included the design and fabrication of a cryostat that allows operation of the cryogenic active member in a space structure testbed.

  17. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  18. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  19. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  20. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  1. 42 CFR 31.14 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Personnel of Former Lighthouse Service § 31.14 Application for treatment; active duty personnel. An applicant for medical...

  2. Selection of active member locations in adaptive structures

    NASA Technical Reports Server (NTRS)

    Chen, G.-S.; Bruno, R.; Salama, M.

    1989-01-01

    The effective use of multiple passive and active members in adaptive structures necessitates that these members be optimally distributed throughout the structure. In truss structures, the problem falls into the class of combinatorial optimization for which the solution becomes exceedingly intractable as the problem size increases. This is overcome by using the simulated annealing algorithm to obtain near optimal locations for passive and/or active members. The maximization of the rate of energy dissipation over a finite time period as the measure of optimality is adopted. The selection of optimal locations for both passive and active members is consistently treated through the use of the energy dissipation rate criterion within the simulated annealing algorithm. Numerical examples are used to illustrate the effectiveness of the methodology for large truss structures.

  3. Theoretical and experimental studies of a truss incorporating active members

    NASA Astrophysics Data System (ADS)

    Edberg, D. L.; Bicos, A. S.; Fuller, C. M.; Tracy, J. J.; Fechter, J. S.

    1992-04-01

    To model the behavior of the piezoelectric elements, a unique finite-element formulation of the piezoelectric struts has been developed which is based on the MSC/NASTRAN CQUAD4 element. The formulation uses the element's Poisson expansion under in-plane loading to make its behavior simulate a piezoelectric member. It is shown that the active members in the MDSSC CSI truss are useful in the investigation of a variety of vibration dissipitation and damage detection techniques.

  4. Sunburn among active component service members, U.S. Armed Forces, 2002-2013.

    PubMed

    2014-07-01

    Sunburn is caused by acute overexposure to ultraviolet (UV) radiation directly from the sun or from artificial UV sources. Service members are at risk of excessive exposure to sunlight due to the nature of their military duties, which often involve working and training outdoors, and deployment to environments where UV radiation is more intense. From January 2002 through December 2013, a total of 19,172 incident cases of clinically significant sunburn were diagnosed among active component service members. Most of the cases (80.2%) were first degree sunburn. The incidence rates of sunburn diagnoses were higher among females, white non-Hispanics, younger age groups, individuals in the Marine Corps or Army, and among enlisted service members. Additionally, the rate among recruits was more than 3.5 times the rate for non-recruits. Sixty-one percent of all diagnosed cases occurred from May through July. Sunburn cases occurred in all areas of the U.S., particularly near major recruit and combat training locations. Service members are strongly advised to practice sun safety as a part of heat illness prevention, including properly using broad-spectrum sunscreen, finding or constructing shade during work and rest, wearing protective clothing and military combat eye protection items, and avoiding tanning booths and sun lamps. PMID:25080329

  5. Navy and Marine Corps active duty mortality patterns for 1995 to 1999.

    PubMed

    Almond, Myron D; Carlton, Jan; Bohnker, Bruce K

    2003-01-01

    The authors analyze all Navy and Marine Corps active duty deaths from January 1, 1995 through December 31, 1999 (Navy, N=1231; Marine Corps, N=701). Data were obtained from official Navy and Marine Corps sources, including the Report of Casualty (DD form 1300) and the Navy Personnel Casualty Report (Control Symbol NMPC 1770-4) or the Marine Corps Personnel Casualty Report (MC-3040-02), as appropriate. Overall fatality rates were 68.2 per 100,000 active duty Navy personnel and 84.2 for active duty Marine Corps personnel. Rates were generally lower than those noted in previous studies and lower than comparable civilian groups. The officer fatality rates were strongly affected by aircraft mishap-related deaths. The only subgroup displaying higher rates than their civilian counterparts was mishap-related deaths for enlisted Marines age 17 to 24 years old. PMID:12546243

  6. Achillon mini-open Achilles tendon repair: early outcomes and return to duty results in U.S. military service members.

    PubMed

    Orr, Justin D; McCriskin, Brendan; Dutton, Jason R

    2013-01-01

    The purpose of this article is to report short-term outcomes and return to duty rates in a cohort of active duty U.S. military personnel who underwent repair of acute Achilles tendon ruptures using the Achillon mini-open technique. Between October 2009 and March 2012, 15 consecutive patients underwent mini-open repair of acute Achilles tendon ruptures using the Achillon device by a single surgeon. Minor and major complications were recorded, and American Orthopaedic Foot and Ankle Society (AOFAS) and pain visual analog scores were recorded at regular follow-up intervals. At mean latest follow-up of 16.7 months postoperatively, all 15 patients had returned to full active duty status without major complications. Specifically, no patient experienced major wound complication, infection, or rerupture. Mean AOFAS score in 9 of 15 patients was 94.1; mean pain visual analog score in 12 of 15 patients was 1.4. The Achillon mini-open technique can be used for treatment of acute Achilles tendon ruptures in appropriately selected high-demand patient populations with the expectation of minimal adverse outcomes. PMID:23449051

  7. Septicemia diagnosed during hospitalizations, active component service members, U.S. Armed Forces, 2000-2012.

    PubMed

    2013-08-01

    During the period 2000 through 2012, the records of 3,360 hospitalized active component service members contained a diagnosis of septicemia. Most of these cases were identified via diagnoses recorded in the first and second diagnostic positions and the numbers and rates of such cases increased dramatically during the period. Rates were higher among women than men and in the oldest and youngest age groups. The most frequent co-occurring diagnoses were pneumonia and infections of the skin and subcutaneous tissue. For the majority of cases of septicemia, no specific etiologic agent was indicated by ICD-9 codes in the record. The most commonly specified agents were Staphylococcus aureus, Escherichia coli, and Streptococcus pneumoniae. Most service members were returned to duty after discharge. The overall mortality associated with hospitalized septicemia cases was 4 percent, but was 5.1 percent for septicemia attributed to gram negative bacteria. Possible reasons why the mortality rate in service members was lower than the rates associated with septicemia in the general population are discussed. PMID:24011371

  8. 78 FR 64011 - Tolling of Activity in Antidumping and Countervailing Duty Proceedings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Tolling of Activity in Antidumping and Countervailing Duty Proceedings AGENCY: United States International Trade Commission. ACTION: Notice. DATES: Effective Date: October 21, 2013. FOR FURTHER INFORMATION CONTACT: Catherine DeFilippo...

  9. 42 CFR 31.5 - Application for treatment; active duty personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., PUBLIC HEALTH SERVICE, AND FORMER LIGHTHOUSE SERVICE Provisions Applicable to Coast Guard, National Ocean... 42 Public Health 1 2010-10-01 2010-10-01 false Application for treatment; active duty personnel. 31.5 Section 31.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN...

  10. Standard of care of erectile dysfunction in U.S. Air Force aircrew and active duty not on flying status.

    PubMed

    Nast, Justin B

    2014-11-01

    In 2011, over 3,000 active duty U.S. Air Force (USAF) members were prescribed a phosphodiesterase inhibitor (PDEI). PDEIs are first-line therapy for treating erectile dysfunction and can have significant side effects that could impact aircrew performance. In total, 200 eligible subject records were randomly sampled from the active duty USAF population of those males filling a prescription for a PDEI in June 2011; 100 of those records were from aviators. The electronic records were reviewed and scored to determine if USAF aeromedical standards for prescribing PDEIs were followed, with a minimum score of 0 for no standards met and a maximum of 3 for all standards met. The average score for both groups was 1, with no significant difference between the group scores. A proper aeromedical disposition was documented in 67% of the aviator records. Although there was no significant difference in standard of care for aviators and nonaviators, the overall documented standard of care was poor. Lack of documentation was the primary reason for the low scores and the low percentage of properly rendered aeromedical dispositions. Proper medical record documentation is important for evaluating quality of care and ensuring compliance with regulations in an Air Force aviator population. PMID:25373059

  11. Certification and Duties of a Director of Physical Activity

    ERIC Educational Resources Information Center

    Carson, Russell

    2012-01-01

    In order for a Comprehensive School Physical Activity Program to meet its full potential, a director of physical activity (DPA) is needed. To train physical educators for this new role, a task force recently created a professional development program endorsed by the National Association for Sport and Physical Education that certifies current…

  12. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission regulation... governors of a self-regulatory organization. (3) Committee member means a member, or functional...

  13. Experimental evaluation of active-member control of precision structures

    NASA Technical Reports Server (NTRS)

    Fanson, James; Blackwood, Gary; Chu, Cheng-Chih

    1989-01-01

    The results of closed loop experiments that use piezoelectric active-members to control the flexible motion of a precision truss structure are described. These experiments are directed toward the development of high-performance structural systems as part of the Control/Structure Interaction (CSI) program at JPL. The focus of CSI activity at JPL is to develop the technology necessary to accurately control both the shape and vibration levels in the precision structures from which proposed large space-based observatories will be built. Structural error budgets for these types of structures will likely be in the sub-micron regime; optical tolerances will be even tighter. In order to achieve system level stability and local positioning at this level, it is generally expected that some form of active control will be required.

  14. STS-110 crew members during TCDT slidewire basket activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- -- STS-110 crew members sit in the slidewire basket, part of emergency egress equipment on the pad. From left are Mission Specialists Steven L. Smith, Lee M.E. Morin and Jerry L. Ross. The crew is taking part in Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown, held at KSC prior to each Space Shuttle flight. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  15. Structural control by the use of piezoelectric active members

    NASA Technical Reports Server (NTRS)

    Fanson, J. L.; Chen, J.-C.

    1987-01-01

    Large Space Structures (LSS) exhibit characteristics which make the LSS control problem different form other control problems. LSS will most likely exhibit low frequency, densely spaced and lightly damped modes. In theory, the number of these modes is infinite. Because these structures are flexible, Vibration Suppression (VS) is an important aspect of LSS operation. In terms of VS, the control actuators should be as low mass as possible, have infinite bandwidth, and be electrically powered. It is proposed that actuators be built into the structure as dual purpose structural elements. A piezoelectric active member is proposed for the control of LSS. Such a device would consist of a piezoelectric actuator and sensor for measuring strain, and screwjack actuator in series for use in quasi-static shape control. An experiment simulates an active member using piezoelectric ceramic thin sheet material on a thin, uniform cantilever beam. The feasibility of using the piezoelectric materials for VS on LSS was demonstrated. Positive positive feedback as a VS control strategy was implemented. Multi-mode VS was achieved with dramatic reduction in dynamic response.

  16. Gender differences in the expression of PTSD symptoms among active duty military personnel.

    PubMed

    Hourani, Laurel; Williams, Jason; Bray, Robert; Kandel, Denise

    2015-01-01

    This study examined gender differences in posttraumatic stress disorder (PTSD) symptoms and symptom factors in the total U.S. active duty force. Data were drawn from the 2008 Department of Defense Survey of Health Related Behaviors among Active Duty Military Personnel including 17,939 men and 6751 women from all services. The results indicated that women expressed more distress than men across almost all the symptoms on the PTSD Checklist except for hypervigilance. Women also scored significantly higher on all four factors examined: Re-experiencing, Avoidance, Emotionally Numb, Hyperarousal. More women than men were distressed by combat experiences that involved some type of violence, such as being wounded, witnessing or engaging in acts of cruelty, engaging in hand-to-hand combat, and, to a lesser extent, handling dead bodies. Men who had been sexually abused had a greater number of symptoms and were consistently more distressed than women on individual symptoms and symptom factors. PMID:25527902

  17. 20 CFR 404.1019 - Work as a member of a uniformed service of the United States.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... including periods of authorized travel to and from that duty; or (6) You are selected for active military or... Atmospheric Administration or the Regular or Reserve Corps of the Public Health Service; (3) You are a member..., 1957, the work is service on active duty or active duty for training but not including...

  18. Healing Touch with Guided Imagery for PTSD in returning active duty military: a randomized controlled trial.

    PubMed

    Jain, Shamini; McMahon, George F; Hasen, Patricia; Kozub, Madelyn P; Porter, Valencia; King, Rauni; Guarneri, Erminia M

    2012-09-01

    Post-traumatic stress disorder (PTSD) remains a significant problem in returning military and warrants swift and effective treatment. We conducted a randomized controlled trial to determine whether a complementary medicine intervention (Healing Touch with Guided Imagery [HT+GI]) reduced PTSD symptoms as compared to treatment as usual (TAU) returning combat-exposed active duty military with significant PTSD symptoms. Active duty military (n = 123) were randomized to 6 sessions (within 3 weeks) of HT+GI vs. TAU. The primary outcome was PTSD symptoms; secondary outcomes were depression, quality of life, and hostility. Repeated measures analysis of covariance with intent-to-treat analyses revealed statistically and clinically significant reduction in PTSD symptoms (p < 0.0005, Cohen's d = 0.85) as well as depression (p < 0.0005, Cohen's d = 0.70) for HT+GI vs. TAU. HT+GI also showed significant improvements in mental quality of life (p = 0.002, Cohen's d = 0.58) and cynicism (p = 0.001, Cohen's d = 0.49) vs. TAU. Participation in a complementary medicine intervention resulted in a clinically significant reduction in PTSD and related symptoms in a returning, combat-exposed active duty military population. Further investigation of GT and biofield therapy approaches for mitigating PTSD in military populations is warranted. PMID:23025129

  19. 32 CFR 161.10 - Benefits for active duty members of the uniformed services.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and DoD Instruction 1330.17, “Armed Services Commissary Operations” (available at http://www.dtic.mil...” (available at http://www.dtic.mil/whs/directives/corres/pdf/133021p.pdf); and DoD Instruction...

  20. Perspective on OECD activities from a non-member country.

    PubMed

    Alexandrova, Nevena; Atanassov, Atanas

    2006-01-01

    The OECD Blue Book, "Recombinant DNA: Safety Considerations" was published in 1986. The developed principles and concepts on the stepwise and case-by-case approach for risk assessment in the Blue Book have been used as a foundation for building national biosafety frameworks and international instruments for the regulation of the products of modern biotechnology. Twenty years after the Blue Book was published, OECD continues its activities on unique identifier systems, information-sharing, consensus documents for the biology of crops, trees and microorganisms with respect to harmonization of regulatory oversight and those of novel food and feed safety. These activities benefit, without any doubt, the international community at large, including OECD non-member countries. In order to strengthen its position in the international arena and to better respond to the needs of the changing world, OECD would be encouraged to participate in a more active manner in the technology transfer process and co-existence debate, together with continuing the organization's efforts on information-sharing and harmonization in the field of biotechnology and biosafety. PMID:17640514

  1. 75 FR 49913 - Active Duty Service Determinations For Civilian or Contractual Groups

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ..., determined that service of the group known as the ``''Honorably Discharged Members of The Gold Coast Native... at Then `American Camp,' Now Named `Burma Camp,' Ghana' '' shall not be considered ``active...

  2. 5 CFR 734.306 - Participation in political activities while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in political activities... (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) POLITICAL ACTIVITIES OF FEDERAL EMPLOYEES Prohibited Activities § 734.306 Participation in political activities while on duty, in uniform, in any room or...

  3. Current Suicidal Ideation among Treatment-Engaged Active Duty Soldiers and Marines

    PubMed Central

    Zimmerman, Lindsey; Villatte, Jennifer L.; Kerbrat, Amanda H.; Atkins, David C.; Flaster, Aaron; Comtois, Kate A.

    2015-01-01

    We examined suicidal ideation among 399 active duty Soldiers and Marines engaged in mental health treatment. Using a generalized linear model controlling for demographic and military factors, depression, and positive traumatic brain injury screen, we confirmed our hypothesis that self-report measures of current PTSD symptoms uniquely predicted suicidal ideation. The association between PTSD severity and suicidal ideation was moderated by gender with women at higher risk as PTSD severity increased. Female Soldiers and Marines with high levels of PTSD should receive additional monitoring and intervention. Self-report measures may aid with risk assessment and identify symptom-related distress associated with suicide risk. PMID:27170848

  4. Fraternity Hazing Revisited: Current Alumni and Active Member Attitudes Toward Hazing.

    ERIC Educational Resources Information Center

    Baier, John L.; Williams, Patrick S.

    1983-01-01

    Studied hazing practices at a large university and compared active and alumni fraternity members' (N=259) attitudes towards them. Results showed alumni accepted hazing more than active members. Most members believed hazing served a valuable purpose and did not create problems in their own chapter. (WAS)

  5. Pilot study of the effects of mixed light touch manual therapies on active duty soldiers with chronic post-traumatic stress disorder and injury to the head.

    PubMed

    Davis, Lauren; Hanson, Brenda; Gilliam, Sara

    2016-01-01

    This pilot study was designed to examine the effects of mixed Light Touch Manual Therapies (LTMT) on headache, anxiety and other symptoms suffered by active duty United States service members experiencing chronic Post-Traumatic Stress Disorder (PTSD). Ten service members diagnosed with PTSD and having a self-reported injury to the head acquired at least two years prior, were provided with two hour-long sessions of mixed LTMT given a week apart. Data to assess the immediate and durable effects were gathered before and after the LTMT sessions. Results indicate that headache, anxiety, and pain interference were significantly reduced during the course of the pilot study. This suggests that mixed LTMT may be helpful in reducing some of the symptoms of PTSD and injury to the head. Further studies will be needed to determine if LTMT is an effective non-pharmacological treatment for headache, anxiety or other problems associated with PTSD or injury to the head. PMID:26891636

  6. Help-Seeking Behaviors Among Active-Duty Military Personnel: Utilization of Chaplains and Other Mental Health Service Providers.

    PubMed

    Morgan, Jessica Kelley; Hourani, Laurel; Lane, Marian E; Tueller, Stephen

    2016-01-01

    Military chaplains not only conduct religious services, but also provide counseling and spiritual support to military service members, operating as liaisons between soldiers and mental health professionals. In this study, active-duty soldiers (N = 889) reported help-seeking behaviors and mental health. Using logistic regressions, we describe the issues for which soldiers reported seeking help, then outline the characteristics of those who are most likely to seek help from a chaplain. Of the soldiers who sought help from a chaplain within the previous year, 29.9% reported high levels of combat exposure, 50.8% screened positive for depression, 39.1% had probable PTSD, and 26.6% screened positive for generalized anxiety disorder. The participant's unit firing on the enemy, personally firing on the enemy, and seeing dead bodies or human remains predicted seeing a chaplain. Future research should examine ways to engage soldiers who have had more combat experiences with the chaplain community to address spiritual issues. PMID:27191375

  7. Help-Seeking Behaviors Among Active-Duty Military Personnel: Utilization of Chaplains and Other Mental Health Service Providers

    PubMed Central

    Morgan, Jessica Kelley; Hourani, Laurel; Lane, Marian E.; Tueller, Stephen

    2016-01-01

    Military chaplains not only conduct religious services, but also provide counseling and spiritual support to military service members, operating as liaisons between soldiers and mental health professionals. In this study, active-duty soldiers (N = 889) reported help-seeking behaviors and mental health. Using logistic regressions, we describe the issues for which soldiers reported seeking help, then outline the characteristics of those who are most likely to seek help from a chaplain. Of the soldiers who sought help from a chaplain within the previous year, 29.9% reported high levels of combat exposure, 50.8% screened positive for depression, 39.1% had probable PTSD, and 26.6% screened positive for generalized anxiety disorder. The participant’s unit firing on the enemy, personally firing on the enemy, and seeing dead bodies or human remains predicted seeing a chaplain. Future research should examine ways to engage soldiers who have had more combat experiences with the chaplain community to address spiritual issues. PMID:27191375

  8. Factors predicting health behaviors among Army Reserve, active duty Army, and civilian hospital employees.

    PubMed

    Wynd, Christine A; Ryan-Wenger, Nancy A

    2004-12-01

    This study identified health-risk and health-promoting behaviors in military and civilian personnel employed in hospitals. Intrinsic self-motivation and extrinsic organizational workplace factors were examined as predictors of health behaviors. Because reservists represent a blend of military and civilian lifestyles, descriptive analyses focused on comparing Army Reserve personnel (n = 199) with active duty Army (n = 218) and civilian employees (n = 193), for a total sample of 610. Self-motivation and social support were significant factors contributing to the adoption of health-promoting behaviors; however, organizational workplace cultures were inconsistent predictors of health among the three groups. Only the active Army subgroup identified a hierarchical culture as having an influence on health promotion, possibly because of the Army's mandatory physical fitness and weight control standards. Social support and self-motivation are essential to promoting health among employees, thus hospital commanders and chief executive officers should encourage strategies that enhance and reward these behaviors. PMID:15646182

  9. The long-term hospitalization experience following military service in the 1991 Gulf War among veterans remaining on active duty, 1994–2004

    PubMed Central

    Hooper, Tomoko I; DeBakey, Samar F; Nagaraj, Barbara E; Bellis, Kimberly S; Smith, Besa; Smith, Tyler C; Gackstetter, Gary D

    2008-01-01

    Background Despite more than a decade of extensive, international efforts to characterize and understand the increased symptom and illness-reporting among veterans of the 1991 Gulf War, concern over possible long-term health effects related to this deployment continue. The purpose of this study was to describe the long-term hospitalization experience of the subset of U.S. Gulf War veterans still on active duty between 1994 and 2004. Methods Gulf War veterans on active duty rosters as of October 1, 1994, were identified (n = 211 642) and compared with veterans who had separated from military service and then assessed for attrition at three-year intervals during a 10-year follow-up period, examining demographic and military service characteristics, Gulf War exposure variables, and hospitalization data. Cox proportional hazard modeling was used to evaluate independent predictors of all-cause hospitalization among those still on active duty and to estimate cumulative probability of hospitalization, 1994–2004, by service branch. Results Members of our 1994 active duty cohort were more likely to be officers, somewhat older, and married compared with those who had separated from the military after serving in the 1991 Gulf War. Selected war-related exposures or experiences did not appear to influence separation with the exception of in-theater presence during the brief ground combat phase. Overall the top three diagnostic categories for hospitalizations were musculo-skeletal, injury and poisoning, and digestive disorders. Diseases of the circulatory system and symptoms, signs, and ill-defined conditions increased proportionately over time. In-theater hospitalization was the only significant independent predictor of long-term hospitalization risk among selected war-related exposures or experiences examined. The cumulative probability of hospitalization was highest for Army and lowest for Marines. Conclusion Our results were generally consistent with a previous

  10. 77 FR 27542 - Agency Information Collection Activities (Bereaved Family Member Satisfaction Survey) Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... AFFAIRS Agency Information Collection Activities (Bereaved Family Member Satisfaction Survey) Under OMB... INFORMATION: Title: Bereaved Family Member Satisfaction Survey, VA Form 10- 21081(NR). OMB Control Number... VA Form 10-21081(NR) will be use to survey family members of deceased veterans on their...

  11. 78 FR 16654 - Certain Activated Carbon From the People's Republic of China: Continuation of Antidumping Duty Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... materials with a lignocellulosic component such as cellulose, including wood, sawdust, paper mill waste and... Initiation of Five-Year (``Sunset'') Review, 77 FR 12562 (March 1, 2012). \\2\\ See Certain Activated Carbon... Duty Order, 77 FR 33420 (June 6, 2012). \\3\\ See Certain Activated Carbon from China: Determination,...

  12. Effect of fuel properties on mutagenic activity in extracts of heavy-duty diesel exhaust particulate

    SciTech Connect

    Rasmussen, R.E. )

    1990-10-01

    The effect of varying fuel properties on the emission of mutagenic materials was studied in diesel exhaust particles from a heavy duty engine run under transient speed and load conditions while using nine fuels varying in aromatics, sulfur and boiling point. Mutagenic activity of the soluble organic fraction (SOF) of the particulate was determined using the Ames Salmonella test system with strain TA98 with and without S9 activation. Increasing mutagenic activity relative to fuel consumed (mutants/lb fuel) or to engine work output (mutants/hp-h) was correlated with increasing fuel aromatics (p less than 0.05), but not with fuel sulfur. Increased fuel sulfur levels were correlated with increased amounts of SOF but with decreasing mutagenic activity of the SOF (mutants/microgram SOF) (p less than 0.05). As a result, mutants/hp-h were essentially the same for high- and low-sulfur fuels with high aromatics. No association was found between the fuels' boiling points and the mutagenic activity of the SOF. Mutagenic activity with S9 was generally lower than without, but the correlations were not changed.

  13. Paralysis as a Presenting Symptom of Hyperthyroidism in an Active Duty Soldier.

    PubMed

    Jennette, John; Tauferner, Dustin

    2015-01-01

    Thyrotoxic periodic paralysis (TPP) is an endocrine disorder presenting with proximal motor weakness, typically greatest in the lower extremities, hypokalemia, and signs or laboratory findings consistent with hyperthyroidism. The incidence of TPP is highest in Asian males. This is a case report of a 30-year-old male active duty Soldier who presented to the emergency department complaining of several recent episodes of lower extremity paralysis. The patient underwent a workup which included serum and cerebrospinal fluid studies, and was found to be hypokalemic and hyperthyroid. Following consultation with neurology, the patient was admitted to the medicine service and treated for thyrotoxic periodic paralysis with potassium replacement and treatment of his hyperthyroidism. Since achieving a euthyroid state, he has had no recurrences of TPP. This disease should be considered in patients presenting with symmetric motor weakness and hypokalemia, whether or not symptoms of hyperthyroidism are elicited during the review of systems. PMID:26606408

  14. Military Beliefs and PTSD in Active Duty U.S. Army Soldiers

    PubMed Central

    Loew, Benjamin; Carter, Sarah; Allen, Elizabeth; Markman, Howard; Stanley, Scott; Rhoades, Galena

    2014-01-01

    Post-traumatic distress after military combat is a major cost of war. One under-investigated factor potentially associated with PTSD symptoms is specific beliefs about one’s military service. This study examined post-deployment self-reports from 272 active-duty U.S. Army soldiers, to investigate potential associations between military-related PTSD symptom severity and three beliefs about the military: the importance and value ascribed to one’s own work in the Army, to current military operations in Iraq and Afghanistan, and to military service in general. Higher scores on these three beliefs were negatively correlated with military-related PTSD symptom severity. However, in a combined regression model that controlled for recent combat exposure, only the belief about current military operations had a significant, unique association with PTSD symptom severity. That is, more positive beliefs about the value of operations in Iraq or Afghanistan were associated with lower PTSD symptoms. PMID:25530729

  15. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time... If I am furloughed to perform active military duty, will I have to complete all aspects of the... period to complete all aspects of relocation is exclusive of time spent on furlough for active...

  16. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time... If I am furloughed to perform active military duty, will I have to complete all aspects of the... period to complete all aspects of relocation is exclusive of time spent on furlough for active...

  17. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time... If I am furloughed to perform active military duty, will I have to complete all aspects of the... period to complete all aspects of relocation is exclusive of time spent on furlough for active...

  18. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time... If I am furloughed to perform active military duty, will I have to complete all aspects of the... period to complete all aspects of relocation is exclusive of time spent on furlough for active...

  19. Functional Improvement Following Diastasis Rectus Abdominus Repair in an Active Duty Navy Female.

    PubMed

    Gallus, Katerina M; Golberg, Kathy F; Field, Robert

    2016-08-01

    Return to physical activity following childbirth can be a difficult process complicated by structural changes during pregnancy. A common problem is the development of a diastasis of the rectus abdominus (DRA), defined as a horizontal separation of the abdominus muscles at the linea alba. Recent data indicate that the greater the distance of separation of the muscle, the worse the functional ability. We describe a 24-year-old active duty U.S. Navy female G1P2 with a diagnosis of DRA. At 2 months postpartum, she was referred to physical therapy because of back pain and inability to meet baseline activities of daily living. After 4 months of physical therapy, she was unable to complete curl ups as required by U.S. Navy physical fitness standards. Abdominoplasty with imbrication of the abdominal wall diastasis was performed followed by additional physical therapy, after which she returned to baseline functioning. The restoration of functional ability postoperatively suggests there is a therapeutic indication for surgical correction of DRA. In high-functioning military patients with DRA who fail to return to baseline level of activity following a trial of physical therapy, surgical intervention should be considered to obtain the optimal functional ability. PMID:27483541

  20. Alcohol and Other Risk Factors for Drowning among Male Active Duty U.S. Army Soldiers

    PubMed Central

    Bell, Nicole S.; Amoroso, Paul J.; Yore, Michelle M.; Senier, Laura; Williams, Jeffrey O.; Smith, Gordon S.; Theriault, Alexis

    2007-01-01

    Background Risk factors for drowning are largely undocumented among military populations. Hypothesis Accident report narratives will provide important information about the role of alcohol use and other behaviors in drownings among active duty male U.S. Army soldiers. Methods Using a case series design, we describe drowning deaths reported to the U.S. Army Safety Center (1980–1997), documenting associated demographic factors, alcohol use, and other risk-taking behaviors. Results Drowning victims (n = 352) were disproportionately young, black, and single, with less time-in-service, and no college experience. Most drownings occurred off-duty (89%). Alcohol use was involved in at least 31% of the cases overall. Alcohol use was also associated with a 10-fold increase in reckless behavior (OR 9.6, 95% CI 4.5–20.7) and was most common among drownings in Europe (OR = 4.3, 95% CI 1.5–13.4). Most drownings occurred where no lifeguard was present (68%), but almost two-thirds occurred in the presence of others, with CPR initiated in less than one-third of these cases. Drownings involving minority victims were less likely to involve alcohol, but more likely to occur in unauthorized swimming areas. While most drownings did not involve violations of safety rules, over one-third of the cases involved some form of reckless behavior, particularly for those under age 21. Conclusions Intervention programs should be tailored to meet the needs of the demographic subgroups at highest risk since behavioral risk factors vary by race and age. CPR training and skills maintenance can improve survival rates. Narrative data are important for developing hypotheses and understanding risk factors for injuries. PMID:11763109

  1. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  2. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  3. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  4. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  5. 29 CFR 2580.412-8 - The nature of the duties or activities to which the bonding requirement relates.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false The nature of the duties or activities to which the bonding requirement relates. 2580.412-8 Section 2580.412-8 Labor Regulations Relating to Labor (Continued) EMPLOYEE... INCOME SECURITY ACT OF 1974 TEMPORARY BONDING RULES Scope and Form of the Bond § 2580.412-8 The nature...

  6. They Self-Ignited: Adult Student Journeys to an Associate's Degree While Active Duty Military or Military Spouse

    ERIC Educational Resources Information Center

    Bibus, Lindsay Pohl

    2013-01-01

    This qualitative study was undertaken in order to gain an understanding of the lived experiences of adult students and how they made meaning of their journey. To that end, through in-depth interviews with twenty participants, the study inquired into the journeys to an associate's degree of adult students who were also active duty military service…

  7. 78 FR 70533 - Certain Activated Carbon From the People's Republic of China: Final Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ...; 2011-2012, 78 FR 26748 (May 8, 2013) (``Preliminary Results''). DATES: Effective Date: November 26....\\12\\ \\2\\ See id. \\3\\ See id., 78 FR at 26749. \\4\\ See Memorandum to Christian Marsh, Deputy Assistant... Results, 78 FR at 26749; see also Notice of Antidumping Duty Order: Certain Activated Carbon from...

  8. Development of an active member using piezoelectric and electrostrictive actuation for control of precision structures

    NASA Technical Reports Server (NTRS)

    Anderson, E. H.; Moore, D. M.; Fanson, J. L.; Ealey, M. A.

    1990-01-01

    The design and development of a zero stiction active member containing piezoelectric and electrostrictive actuator motors is presented. The active member is intended for use in submicron control of structures. Experimental results are shown which illustrate actuator and device characteristics relevant to precision control applications.

  9. Biological activity of particle exhaust emissions from light-duty diesel engines.

    PubMed

    Carraro, E; Locatelli, A L; Ferrero, C; Fea, E; Gilli, G

    1997-01-01

    Whole diesel exhaust has been classified recently as a probable carcinogen, and several genotoxicity studies have found particulate exhaust to be clearly mutagenic. Moreover, genotoxicity of diesel particulate is greatly influenced by fuel nature and type of combustion. In order to obtain an effective environmental pollution control, combustion processes using alternative fuels are being analyzed presently. The goal of this study is to determine whether the installation of exhaust after treatment-devices on two light-duty, exhaust gas recirculation (EGR) valve-equipped diesel engines (1930 cc and 2500 cc) can reduce the mutagenicity associated with particles collected during U.S.A. and European driving cycles. Another interesting object was to compare the ability of alternative biodiesel and conventional diesel fuels to reduce the mutagenic activity associated with collected particles from two light duty diesel engines (both 1930 cc) during the European driving cycle. SOF mutagenicity was assayed using the Salmonella/microsome test (TA 98 and TA 100 strains, +/- S9 fraction). In the first part of our study, the highest mutagenicity was revealed by TA98 strain without enzymatic activation, suggesting a direct-acting mutagenicity prevalence in diesel particulate. The 2500 cc engine revealed twofold mutagenic activity compared with the 1930 cc engine (both EGR valve equipped), whereas an opposite result was found in particulate matter amount. The use of a noncatalytic ceramic trap produced a decrease of particle mutagenic activity in the 2500 cc car, whereas an enhancement in the 1930 cc engine was found. The catalytic converter and the electrostatic filter installed on the 2500 cc engine yielded a light particle amount and an SOF mutagenicity decrease. A greater engine stress was obtained using European driving cycles, which caused the strongest mutagenicity/km compared with the U.S.A. cycles. In the second part of the investigation, even though a small number of

  10. 41 CFR 302-2.9 - If I am furloughed to perform active military duty, will I have to complete all aspects of the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... perform active military duty, will I have to complete all aspects of the relocation within the time limitation? 302-2.9 Section 302-2.9 Public Contracts and Property Management Federal Travel Regulation System... If I am furloughed to perform active military duty, will I have to complete all aspects of...

  11. On the placement of active members in adaptive truss structures for vibration control

    NASA Technical Reports Server (NTRS)

    Lu, L.-Y.; Utku, S.; Wada, B. K.

    1992-01-01

    The problem of optimal placement of active members which are used for vibration control in adaptive truss structures is investigated. The control scheme is based on the method of eigenvalue assignment as a means of shaping the transient response of the controlled adaptive structures, and the minimization of required control action is considered as the optimization criterion. To this end, a performance index which measures the control strokes of active members is formulated in an efficient way. In order to reduce the computation burden, particularly for the case where the locations of active members have to be selected from a large set of available sites, several heuristic searching schemes are proposed for obtaining the near-optimal locations. The proposed schemes significantly reduce the computational complexity of placing multiple active members to the order of that when a single active member is placed.

  12. Sleep Disorders and Associated Medical Comorbidities in Active Duty Military Personnel

    PubMed Central

    Mysliwiec, Vincent; McGraw, Leigh; Pierce, Roslyn; Smith, Patrick; Trapp, Brandon; Roth, Bernard J.

    2013-01-01

    Study Objectives: Describe the prevalence of sleep disorders in military personnel referred for polysomnography and identify relationships between demographic characteristics, comorbid diagnoses, and specific sleep disorders. Design: Retrospective cross-sectional study. Setting: Military medical treatment facility. Participants: Active duty military personnel with diagnostic polysomnogram in 2010. Measurements: Primary sleep disorder rendered by review of polysomnogram and medical record by a board certified sleep medicine physician. Demographic characteristics and conditions of posttraumatic stress disorder (PTSD), mild traumatic brain injury (mTBI), anxiety, depression, and pain syndromes determined by medical record review. Results: Primary sleep diagnoses (n = 725) included: mild obstructive sleep apnea (OSA), 207 (27.2%); insomnia, 188 (24.7%); moderate-to-severe OSA, 183 (24.0 %); and paradoxical insomnia,39 (5.1%); behaviorally induced insufficient sleep syndrome, 68 (8.9%) and snoring, 40 (5.3%) comprised our control group. Short sleep duration (< 5 h) was reported by 41.8%. Overall 85.2% had deployed, with 58.1% having one or more comorbid diagnoses. Characteristics associated with moderate-to-severe OSA were age (adjusted odds ratio [OR], 1.03 [95% confidence interval {CI}, 1.0–1.05], sex (male) (adjusted OR, 19.97 [95% CI, 2.66–150.05], anxiety (adjusted OR, 0.58 [95% CI, 0.34–0.99]), and body mass index, BMI (adjusted OR 1.19 [95% CI, 1.13–1.25]; for insomnia, characteristics included PTSD (adjusted OR, 2.12 [95% CI, 1.31–3.44]), pain syndromes (adjusted OR, 1.48 [95%CI, 1.01–2.12]), sex (female) (adjusted OR, 0.22 [95% CI, 0.12–0.41]) and lower BMI (adjusted OR, 0.91 [95% CI, 0.87, 0.95]). Conclusions: Service-related illnesses are prevalent in military personnel who undergo polysomnography with significant associations between PTSD, pain syndromes, and insomnia. Despite having sleep disorders, almost half reported short sleep duration

  13. Performance validity test and neuropsychological assessment battery screening module performances in an active-duty sample with a history of concussion.

    PubMed

    Grills, Chad E; Armistead-Jehle, Patrick

    2016-01-01

    The current retrospective investigation sought to replicate previous findings demonstrating the significant impact of performance validity test (PVT) performance and evaluation context on neuropsychological testing. We examined differences on performance validity testing between active-duty service members undergoing neurocognitive screening for concussion who were seen in a clinical context and those who were seen in a disability-seeking context, as well as the overall impact of PVT performance on a neurocognitive screening battery. Overall, 38.2% of the sample failed the Word Memory Test (WMT). Of those involved in a disability evaluation, the failure rate was 51.9%, which was significantly higher than the 36.8% failure rate among those evaluated in a clinical context. The effect size of WMT performance on a cognitive screening measure was also large. The current retrospective analysis served to replicate previous work. PMID:26943837

  14. 78 FR 76153 - Agency Information Collection Activities: Entry and Manifest of Merchandise Free of Duty, Carrier...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-16

    ... Register (78 FR 59365) on September 26, 2013, allowing for a 60-day comment period. This notice allows for... Mexico with merchandise conditionally free of duty. CBP uses this form to authorize the entry of...

  15. Analysis of heavy-duty diesel truck activity and emissions data

    NASA Astrophysics Data System (ADS)

    Huai, Tao; Shah, Sandip D.; Wayne Miller, J.; Younglove, Ted; Chernich, Donald J.; Ayala, Alberto

    Despite their relatively small population, heavy-duty diesel vehicles (HDDVs) are (in 2005) disproportionate contributors to the emissions inventory for oxides of nitrogen (NO x) and particulate matter (PM) due to their high individual vehicle emissions rates, lack of engine aftertreatment, and high vehicle miles traveled. Beginning in the early 1990s, heavy-duty engine manufacturers began equipping their engines with electronic sensors and controls and on-board electronic computer modules (ECMs) to manage these systems. These ECMs can collect and store both periodic and lifetime engine operation data for a variety of engine and vehicle parameters including engine speed and load, time at idle, average vehicle speed, etc. The University of California, Riverside (UCR), under a contract with the California Air Resources Board (CARB), performed data analysis of 270 ECM data sets obtained from the CARB. The results from this analysis have provided insights into engine/vehicle operation that have not been obtained from previous on-board datalogger studies since those previous studies focused on vehicle operation and did not collect engine operating data. Results indicate that HDDVs spend a considerable amount of time at high-speed cruise and at idle and that a smaller percentage of time is spent under transient engine/vehicle operation. These results are consistent with other HDDV activity studies, and provide further proof of the validity of assumptions in CARB's emission factor (EMFAC2002) model. An additional important contribution of this paper is that the evaluation of vehicle ECM data provides several advantages over traditional global positioning system (GPS) and datalogger studies: (1) ECM data is significantly cheaper than the traditional method (50 record -1 vs. ˜2000 record -1) and (2) ECM data covers vehicle operation over the entire life of the vehicle, whereas traditional surveys cover only short periods of surveillance (days, weeks, or months). It is

  16. A hand speed-duty cycle equation for estimating the ACGIH hand activity level rating.

    PubMed

    Akkas, Oguz; Azari, David P; Chen, Chia-Hsiung Eric; Hu, Yu Hen; Ulin, Sheryl S; Armstrong, Thomas J; Rempel, David; Radwin, Robert G

    2015-01-01

    An equation was developed for estimating hand activity level (HAL) directly from tracked root mean square (RMS) hand speed (S) and duty cycle (D). Table lookup, equation or marker-less video tracking can estimate HAL from motion/exertion frequency (F) and D. Since automatically estimating F is sometimes complex, HAL may be more readily assessed using S. Hands from 33 videos originally used for the HAL rating were tracked to estimate S, scaled relative to hand breadth (HB), and single-frame analysis was used to measure D. Since HBs were unknown, a Monte Carlo method was employed for iteratively estimating the regression coefficients from US Army anthropometry survey data. The equation: HAL = 10[e(-15:87+0:02D+2:25 ln S)/(1+e(-15:87+0:02D+2:25 ln S)], R(2) = 0.97, had a residual range ± 0.5 HAL. The S equation superiorly fits the Latko et al. ( 1997 ) data and predicted independently observed HAL values (Harris 2011) better (MSE = 0.16) than the F equation (MSE = 1.28). PMID:25343278

  17. A frequency-duty cycle equation for the ACGIH hand activity level.

    PubMed

    Radwin, Robert G; Azari, David P; Lindstrom, Mary J; Ulin, Sheryl S; Armstrong, Thomas J; Rempel, David

    2015-01-01

    A new equation for predicting the hand activity level (HAL) used in the American Conference for Government Industrial Hygienists threshold limit value®(TLV®) was based on exertion frequency (F) and percentage duty cycle (D). The TLV® includes a table for estimating HAL from F and D originating from data in Latko et al. (Latko WA, Armstrong TJ, Foulke JA, Herrin GD, Rabourn RA, Ulin SS, Development and evaluation of an observational method for assessing repetition in hand tasks. American Industrial Hygiene Association Journal, 58(4):278-285, 1997) and post hoc adjustments that include extrapolations outside of the data range. Multimedia video task analysis determined D for two additional jobs from Latko's study not in the original data-set, and a new nonlinear regression equation was developed to better fit the data and create a more accurate table. The equation, HAL = 6:56 ln D[F(1:31) /1+3:18 F(1:31), generally matches the TLV® HAL lookup table, and is a substantial improvement over the linear model, particularly for F>1.25 Hz and D>60% jobs. The equation more closely fits the data and applies the TLV® using a continuous function. PMID:25343340

  18. Prolonged Exposure Therapy With Veterans and Active Duty Personnel Diagnosed With PTSD and Traumatic Brain Injury.

    PubMed

    Wolf, Gregory K; Kretzmer, Tracy; Crawford, Eric; Thors, Christina; Wagner, H Ryan; Strom, Thad Q; Eftekhari, Afsoon; Klenk, Megan; Hayward, Laura; Vanderploeg, Rodney D

    2015-08-01

    The present study used archival clinical data to analyze the delivery and effectiveness of prolonged exposure (PE) and ancillary services for posttraumatic stress disorder (PTSD) among Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn veterans (N = 69) with histories of mild to severe traumatic brain injury (TBI). Data from standard clinical assessments of veterans and active duty personnel treated in both inpatient and outpatient programs at 2 Department of Veteran Affairs medical centers were examined. Symptoms were assessed with self-report measures of PTSD (PTSD Checklist) and depression (Beck Depression Inventory-II) before and throughout therapy. Mixed linear models were utilized to determine the slope of reported symptoms throughout treatment, and the effects associated with fixed factors such as site, treatment setting (residential vs. outpatient), and TBI severity were examined. Results demonstrated significant decreases in PTSD, B = -3.00, 95% CI [-3.22, -2.78]; t(210) = -13.5; p < .001, and in depressive symptoms, B = -1.46, 95% CI [-1.64, -1.28]; t(192) = -8.32; p < .001. The effects of PE treatment did not differ by clinical setting and participants with moderate to severe injuries reported more rapid gains than those with a history of mild TBI. The results provide evidence that PE may well be effective for veterans with PTSD and TBI. PMID:26201688

  19. VR PTSD exposure therapy results with active duty OIF/OEF combatants.

    PubMed

    Rizzo, Albert A; Difede, Joann; Rothbaum, Barbara O; Johnston, Scott; McLay, Robert N; Reger, Greg; Gahm, Greg; Parsons, Thomas; Graap, Ken; Pair, Jarrell

    2009-01-01

    Post Traumatic Stress Disorder (PTSD) is reported to be caused by traumatic events that are outside the range of usual human experience including military combat, violent personal assault, being kidnapped or taken hostage and terrorist attacks. Reports indicate that at least 1 out of 6 Iraq War veterans are exhibiting symptoms of depression, anxiety and PTSD. Virtual Reality exposure therapy has been previously used for PTSD with reports of positive outcomes. This paper will present a brief description of the USC/ICT Virtual Iraq/Afghanistan PTSD therapy application and present clinical outcome data from active duty patients treated at the Naval Medical Center-San Diego (NMCSD) as of October 2009. Initial outcomes from the first twenty patients to complete treatment indicate that 16 no longer meet diagnostic criteria for PTSD at post treatment. Research and clinical tests using the Virtual Iraq/Afghanistan software are also currently underway at Weill Cornell Medical College, Emory University, Fort Lewis and WRAMC along with 20 other test sites. PMID:19377167

  20. Space activities and radiation protection of crew members

    NASA Astrophysics Data System (ADS)

    Straube, Ulrich; Berger, Thomas; Reitz, Guenther; Facius, Rainer; Reiter, Thomas; Kehl, Marcel; Damann, M. D. Volker; Tognini, Michel

    Personnel working as crew in space-based activities e.g. professional astronauts and cosmo-nauts but also -to a certain extend-space flight participants ("space tourists"), demand health and safety considerations that have to include radiation protection measures. The radiation environment that a crew is exposed to during a space flight, differs significantly to that found on earth including commercial aviation, mainly due to the presence of heavy charged particles with great potential for biological damage. The exposure exceeds those routinely received by terrestrial radiation workers. A sequence of activities has to be conducted targeting to mitigate adverse effects of space radiation. Considerable information is available and applied through the joint efforts of the Space Agencies that are involved in the operations of the International Space Station, ISS. This presentation will give an introduction to the current measures for ra-diation monitoring and protection of astronauts of the European Space Agency (ESA). It will include information: on the radiation protection guidelines that shall ensure the proper imple-mentation and execution of radiation protection measures, the operational hardware used for radiation monitoring and personal dosimetry on ISS, as well as information about operational procedures that are applied.

  1. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. - As part of Crew Equipment Interface Test activities, STS-113 Mission Specialists Michael Lopez-Alegria (left) and John Herrington (center) look over equipment that will be carried on the mission. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  2. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- As part of Crew Equipment Interface Test activities, STS-113 Mission Specialists John Herrington (left) and Michael Lopez-Alegria (center) practice working with equipment in Endeavour. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  3. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- As part of Crew Equipment Interface Test activities, STS-113 Mission Specialists Michael Lopez-Alegria (left) and John Herrington (right) practice working with flight equipment in Endeavour. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  4. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- As part of Crew Equipment Interface Test activities, STS-113 Mission Specialist John Herrington looks over paperwork for equipment in Endeavour that will be carried on the mission. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  5. Prevalence and correlates of needle-stick injuries among active duty police officers in Tijuana, Mexico

    PubMed Central

    Mittal, María Luisa; Beletsky, Leo; Patiño, Efraín; Abramovitz, Daniela; Rocha, Teresita; Arredondo, Jaime; Bañuelos, Arnulfo; Rangel, Gudelia; Strathdee, Steffanie A

    2016-01-01

    Introduction Police officers are at an elevated risk for needle-stick injuries (NSI), which pose a serious and costly occupational health risk for HIV and viral hepatitis. However, research on NSIs among police officers is limited, especially in low- and middle-income countries. Despite the legality of syringe possession in Mexico, half of people who inject drugs (PWID) in Tijuana report extrajudicial syringe-related arrests and confiscation by police, which has been associated with needle-sharing and HIV infection. We assessed the prevalence and correlates of NSIs among Tijuana police officers to inform efforts to improve occupational safety and simultaneously reduce HIV risks among police and PWID. Methods Tijuana's Department of Municipal Public Safety (SSPM) is among Mexico's largest. Our binational, multi-sectoral team analyzed de-identified data from SSPM's 2014 anonymous self-administered occupational health survey. The prevalence of NSI and syringe disposal practices was determined. Logistic regression with robust variance estimation via generalized estimating equations identified factors associated with ever having an occupational NSI. Results Approximately one-quarter of the Tijuana police force was given the occupational health survey (N=503). Respondents were predominantly male (86.5%) and ≤35 years old (42.6%). Nearly one in six officers reported ever having a NSI while working at SSPM (15.3%), of whom 14.3% reported a NSI within the past year. Most participants reported encountering needles/syringes while on duty (n=473, 94%); factors independently associated with elevated odds of NSIs included frequently finding syringes that contain drugs (adjusted odds ratio (AOR): 2.98; 95% confidence interval (CI): 1.56–5.67) and breaking used needles (AOR: 2.25; 95% CI: 1.29–3.91), while protective factors included being willing to contact emergency services in case of NSIs (AOR: 0.39; 95% CI: 0.22–0.69), and wearing needle-stick resistant gloves (AOR: 0

  6. Communist purges of Soviet Academy of Sciences members and solar activity

    NASA Astrophysics Data System (ADS)

    Tomilin, Konstantin A.

    The author is investigating the corelation between the intansity of Communsit purges under Members of the Academy of Sciences of USSR and Solar Activity, based on previous researches by Alexander Leonidovich Chizhevskij (1897-1964).

  7. Which Members of the Microbial Communities Are Active? Microarrays

    NASA Astrophysics Data System (ADS)

    Morris, Brandon E. L.

    only at the early stages of understanding the microbial processes that occur in petroliferous formations and the surrounding subterranean environment. Important first steps in characterising the microbiology of oilfield systems involve identifying the microbial community structure and determining how population diversity changes are affected by the overall geochemical and biological parameters of the system. This is relatively easy to do today by using general 16S rRNA primers for PCR and building clone libraries. For example, previous studies using molecular methods characterised many dominant prokaryotes in petroleum reservoirs (Orphan et al., 2000) and in two Alaskan North Slope oil facilities (Duncan et al., 2009; Pham et al., 2009). However, the problem is that more traditional molecular biology approaches, such as 16S clone libraries, fail to detect large portions of the community perhaps missing up to half of the biodiversity (see Hong et al., 2009) and require significant laboratory time to construct large libraries necessary to increase the probability of detecting the majority of even bacterial biodiversity. In the energy sector, the overarching desire would be to quickly assess the extent of in situ hydrocarbon biodegradation or to disrupt detrimental processes such as biofouling, and in these cases it may not be necessary to identify specific microbial species. Rather, it would be more critical to evaluate metabolic processes or monitor gene products that are implicated in the specific activity of interest. Research goals such as these are well suited for a tailored application of microarray technology.

  8. An analysis of risk domains associated with drug transitions of active Latino gang members.

    PubMed

    De La Rosa, Mario; Rugh, Douglas; Rice, Christopher

    2006-01-01

    Alcohol and illicit drug abuse is a serious problem among male Latino gang members. Research indicates that gang members increase their drug use while they are members, and use more drugs after they leave the gangs. This manuscript reports on data reflecting the influences of individual, familial, peer, and community factors on the number of drug use transitions that Latino gang members undergo during their drug using careers. Data from this study were collected from interviews conducted with seventy-six active Latino gang members. The study's results indicate that age at the time of interview and lower age of drug onset were associated with a greater number of drug use transitions. Positive family attitudes toward deviance, friend drug use, school truancy, conflict with parents, and living in neighborhoods with a high level of crime were also found to be associated with increased drug use transitions. PMID:17088228

  9. HEAVY DUTY DIESEL VEHICLE LOAD ESTIMATION: DEVELOPMENT OF VEHICLE ACTIVITY OPTIMIZATION ALGORITHM

    EPA Science Inventory

    The Heavy-Duty Vehicle Modal Emission Model (HDDV-MEM) developed by the Georgia Institute of Technology(Georgia Tech) has a capability to model link-specific second-by-second emissions using speed/accleration matrices. To estimate emissions, engine power demand calculated usin...

  10. 77 FR 60133 - Agency Information Collection Activities: Deferral of Duty on Large Yachts Imported for Sale

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... Large Yachts Imported for Sale AGENCY: U.S. Customs and Border Protection (CBP), Department of Homeland... concerning Deferral of Duty on Large Yachts Imported for Sale. This request for comment is being made... Large Yachts Imported for Sale. OMB Number: 1651-0080. Form Number: None. Abstract: This collection...

  11. 75 FR 78726 - Agency Information Collection Activities: North American Free Trade Agreement Duty Deferral

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... requirement concerning the North American Free Trade Agreement (NAFTA) Duty Deferral. This request for comment...: 1651-0071. Abstract: The provisions of North American Free Trade Agreement (NAFTA) were adopted by the U.S. with the enactment of the North American Free Trade Agreement Implementation Act of 1993...

  12. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... on duty, in uniform, in any room or building occupied in the discharge of official duties, or using a... room or building occupied in the discharge of official duties, or using a Federal vehicle. (a) This... building occupied in the discharge of official duties, or while using a Government-owned or leased...

  13. It's Academic: Public Policy Activities Among Faculty Members in a Department of Medicine

    PubMed Central

    Jacobs, Douglas B.; Greene, Meredith; Bindman, Andrew B.

    2014-01-01

    Problem To investigate whether and how faculty members in a Department of Medicine are engaged in public policy activities. Approach Between February and April 2011 the authors conducted a cross-sectional web-based survey of all active Department of Medicine (DOM) faculty members at the University of California, San Francisco (UCSF). Survey questions covered demographics, academic role, academic rank, and participation in three specific public policy activities during the past five years: (1) policy related research, (2) expert advice to government officials, and (3) public policy advocacy in collaboration with organizations outside government. Outcomes Two hundred twenty of 553 faculty (40%) responded to the survey. One hundred twenty-four faculty members (56% of respondents and 22% of total active faculty) reported that they were engaged in at least one of the three types of policy related activities: 51 (23%) conducted policy related research, 67 (30%) provided expert advice to government officials, and 93 (42%) collaborated with organizations to advocate for public policy. Higher faculty rank was significantly associated with faculty members reporting that they were involved in one or more of the three policy activities (P = .04). Next Steps Academic departments should identify public policy expertise among their faculty and leverage this expertise by facilitating opportunities to develop a shared faculty awareness of their public policy activities, by supporting the establishment of mentoring relationships for less experienced faculty in the area of public policy, and by incorporating standards of excellence for work in public policy into the promotions process. PMID:23969373

  14. Thyroid disorders among active component military members, U.S. Armed Forces, 2002-2011.

    PubMed

    2012-10-01

    During 2002-2011, among active component U.S. military members, the rates of idiopathic hypothyroidism were 39.7 and 7.8 per 10,000 person-years among females and males, respectively. Unadjusted rates of idiopathic hypothyroidism and chronic thyroiditis (e.g., Hashimoto's disease) were at least twice as high among white, non-Hispanic as black, non-Hispanic service members. However, black, non-Hispanic service members had higher rates of goiter and thyrotoxicosis. Increasing rates of thyroid disorders during the period were accompanied by increases in numbers of screening tests for thyroid function recorded during outpatient visits. Increased thyroid function testing since the beginning of the wars in Iraq and Afghanistan may reflect increased testing of military members with mental disorders (e.g., depression, irritability, PTSD), musculoskeletal pain, sleep disorders, menstrual/fertility abnormalities, obesity, and other conditions which have sharply increased in prevalence over the same period. PMID:23121006

  15. An Uncharacterized Member of the Ribokinase Family in Thermococcus kodakarensis Exhibits myo-Inositol Kinase Activity*

    PubMed Central

    Sato, Takaaki; Fujihashi, Masahiro; Miyamoto, Yukika; Kuwata, Keiko; Kusaka, Eriko; Fujita, Haruo; Miki, Kunio; Atomi, Haruyuki

    2013-01-01

    Here we performed structural and biochemical analyses on the TK2285 gene product, an uncharacterized protein annotated as a member of the ribokinase family, from the hyperthermophilic archaeon Thermococcus kodakarensis. The three-dimensional structure of the TK2285 protein resembled those of previously characterized members of the ribokinase family including ribokinase, adenosine kinase, and phosphofructokinase. Conserved residues characteristic of this protein family were located in a cleft of the TK2285 protein as in other members whose structures have been determined. We thus examined the kinase activity of the TK2285 protein toward various sugars recognized by well characterized ribokinase family members. Although activity with sugar phosphates and nucleosides was not detected, kinase activity was observed toward d-allose, d-lyxose, d-tagatose, d-talose, d-xylose, and d-xylulose. Kinetic analyses with the six sugar substrates revealed high Km values, suggesting that they were not the true physiological substrates. By examining activity toward amino sugars, sugar alcohols, and disaccharides, we found that the TK2285 protein exhibited prominent kinase activity toward myo-inositol. Kinetic analyses with myo-inositol revealed a greater kcat and much lower Km value than those obtained with the monosaccharides, resulting in over a 2,000-fold increase in kcat/Km values. TK2285 homologs are distributed among members of Thermococcales, and in most species, the gene is positioned close to a myo-inositol monophosphate synthase gene. Our results suggest the presence of a novel subfamily of the ribokinase family whose members are present in Archaea and recognize myo-inositol as a substrate. PMID:23737529

  16. Characteristics of suicides among US army active duty personnel in 17 US states from 2005 to 2007.

    PubMed

    Logan, Joseph; Skopp, Nancy A; Karch, Debra; Reger, Mark A; Gahm, Gregory A

    2012-03-01

    Suicides are increasing among active duty US Army soldiers. To help focus prevention strategies, we characterized 56 US Army suicides that occurred from 2005 to 2007 in 17 US states using 2 large-scale surveillance systems. We found that intimate partner problems and military-related stress, particularly job stress, were common among decedents. Many decedents were also identified as having suicidal ideation, a sad or depressed mood, or a recent crisis before death. Focusing efforts to prevent these forms of stress might reduce suicides among soldiers. PMID:22390599

  17. Precipitating circumstances of suicide among active duty U.S. Army personnel versus U.S. civilians, 2005-2010.

    PubMed

    Logan, Joseph E; Skopp, Nancy A; Reger, Mark A; Gladden, Matt; Smolenski, Derek J; Floyd, C Faye; Gahm, Gregory A

    2015-02-01

    To help understand suicide among soldiers, we compared suicide events between active duty U.S. Army versus civilian decedents to identify differences and inform military prevention efforts. We linked 141 Army suicide records from 2005 to 2010 to National Violent Death Reporting System (NVDRS) data. We described the decedents' military background and compared their precipitators of death captured in NVDRS to those of demographically matched civilian suicide decedents. Both groups commonly had mental health and intimate partner precipitating circumstances, but soldier decedents less commonly disclosed suicide intent. PMID:25093259

  18. Unusual Late Presentation of Hemophilia A in an Active Duty U.S. Marine Following Open Shoulder Surgery.

    PubMed

    Shapiro, Bennett H; Minter, Alex R; McDonald, Lucas S

    2015-12-01

    Hemophilia A is clotting disorder affecting 8:100,000 males in the United States. It is an X-linked recessive genetic disorder, although about one-third of cases occur spontaneously without known family history. Because of the risk of uncontrolled hemorrhage on the battlefield, hemophilia and other bleeding disorders exclude individuals from service in the U.S. military. We report a case of an active duty U.S. Marine whose underlying diagnosis of Hemophilia A was discovered and treated by a multidisciplinary team of orthopedic surgeons and hematologists following recurrent hematomas after open rotator cuff surgery. The patient gave informed consent for publication. PMID:26633674

  19. Precipitating Circumstances of Suicide among Active Duty U.S. Army Personnel Versus U.S. Civilians, 2005–2010

    PubMed Central

    Logan, Joseph E; Skopp, Nancy A; Reger, Mark A; Gladden, Matt; Smolenski, Derek J; Floyd, C Faye; Gahm, Gregory A

    2015-01-01

    To help understand suicide among soldiers, we compared suicide events between active duty U.S. Army versus civilian decedents to identify differences and inform military prevention efforts. We linked 141 Army suicide records from 2005 to 2010 to National Violent Death Reporting System (NVDRS) data. We described the decedents’ military background and compared their precipitators of death captured in NVDRS to those of demographically matched civilian suicide decedents. Both groups commonly had mental health and intimate partner precipitating circumstances, but soldier decedents less commonly disclosed suicide intent. PMID:25093259

  20. Contribution of transition metals in the reactive oxygen species activity of PM emissions from retrofitted heavy-duty vehicles

    NASA Astrophysics Data System (ADS)

    Verma, Vishal; Shafer, Martin M.; Schauer, James J.; Sioutas, Constantinos

    2010-12-01

    We assessed the contribution of water-soluble transition metals to the reactive oxygen species (ROS) activity of diesel exhaust particles (DEPs) from four heavy-duty vehicles in five retrofitted configurations (V-SCRT, Z-SCRT, DPX, hybrid, and school bus). A heavy-duty truck without any control device served as the baseline vehicle. Particles were collected from all vehicle-configurations on a chassis dynamometer under three driving conditions: cruise (80 km h -1), transient UDDS, and idle. A sensitive macrophage-based in vitro assay was used to determine the ROS activity of collected particles. The contribution of water-soluble transition metals in the measured activity was quantified by their removal using a Chelex ® complexation method. The study demonstrates that despite an increase in the intrinsic ROS activity (per mass basis) of exhaust PM with use of most control technologies, the overall ROS activity (expressed per km or per h) was substantially reduced for retrofitted configurations compared to the baseline vehicle. Chelex treatment of DEPs water extracts removed a substantial (≥70%) and fairly consistent fraction of the ROS activity, which ascertains the dominant role of water-soluble metals in PM-induced cellular oxidative stress. However, relatively lower removal of the activity in few vehicle-configurations (V-SCRT, DPX and school bus idle), despite a large aggregate metals removal, indicated that not all species were associated with the measured activity. A univariate regression analysis identified several transition metals (Fe, Cr, Co and Mn) as significantly correlated ( R > 0.60; p < 0.05) with the ROS activity. Multivariate linear regression model incorporating Fe, Cr and Co explained 90% of variability in ROS levels, with Fe accounting for the highest (84%) fraction of the variance.

  1. Perceived Environmental Church Support and Physical Activity among Black Church Members

    ERIC Educational Resources Information Center

    Baruth, Meghan; Wilcox, Sara; Saunders, Ruth P.; Hooker, Steven P.; Hussey, James R.; Blair, Steven N.

    2013-01-01

    Background: Churches are an appealing setting for implementing health-related behavior change programs. Purpose: The objective of the study was to examine the relationship between perceived environmental church support for physical activity (PA) and PA behaviors. Method: Black church members from South Carolina ("n" = 309) wore an…

  2. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  3. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  4. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  5. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  6. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  7. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What capacity-building activities may AmeriCorps members perform? 2520.30 Section 2520.30 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  8. Mutualistic Benefits Generate an Unequal Distribution of Risky Activities Among Unrelated Group Members

    NASA Astrophysics Data System (ADS)

    Kukuk, Penelope F.; Ward, Seamus A.; Jozwiak, Amy

    Recent studies provide a new challenge to the adequacy of theories concerning the evolution of cooperation among nonrelatives: some individuals perform high-risk activities while others do not. We examined a communal hymenopteran species, Lasioglossum(Chilalictus)hemichalceum, to determine why group members engaged in demonstrably risky activities (foraging) tolerate the selfish behavior (remaining in the nest) of unrelated nestmates. Experimental removal of adult females indicated that their presence is required for the protection of brood from ant predators. Nonforagers ensure the continued presence of adults in the nest if the risk-taking foragers die, thereby safeguarding the survival of forager offspring. This results in an unequal distribution of risky activities within social groups in which avoidance of risky activities by some group members is ultimately beneficial to risk takers.

  9. 14 CFR 117.13 - Flight duty period: Unaugmented operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... applicable flight duty period is based on the local time at the theater in which the flightcrew member was... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight duty period: Unaugmented operations... FLIGHT AND DUTY LIMITATIONS AND REST REQUIREMENTS: FLIGHTCREW MEMBERS (EFF. 1-4-14) § 117.13 Flight...

  10. Mental Health and Substance Use Factors Associated with Unwanted Sexual Contact among U.S. Active Duty Service Women

    PubMed Central

    Stahlman, Shauna; Javanbakht, Marjan; Cochran, Susan; Hamilton, Alison B.; Shoptaw, Steven; Gorbach, Pamina M.

    2015-01-01

    Many U.S. military women are exposed to unwanted sexual contact during military service, which can have important implications for mental health. Using data from the 2008 Department of Defense Survey of Health Related Behaviors, we employed multiple logistic regression methods to examine whether unwanted sexual contact was associated with stress, screening positive for mental disorders, or substance use, among active duty service women. The sample included 7,415 female military personnel, of whom 13.4% reported unwanted sexual contact (including any touching of genitals) since entering the military. After adjusting for potentially confounding variables, factors independently associated with unwanted sexual contact included military-related stress (Adjusted Odds Ratio [AOR] = 2.44), family/personal life-related stress (AOR = 1.78), and gender-related stress (AOR = 1.98) in the past 12 months. In addition, screening positive for depression, anxiety, posttraumatic stress disorder, psychological distress, and suicidal ideation or attempt were associated with unwanted sexual contact (AOR = 1.57–2.11). For drug/alcohol use, only misuse of tranquilizers/muscle relaxers (past 12 months) was associated with report of unwanted sexual contact (AOR = 1.35). Given the prevalence of unwanted sexual contact and corresponding adverse health outcomes in this sample of active duty women, strategies to create military structural/cultural changes and reduce gender-related stress and sexism are needed. PMID:25976935

  11. Mental Health and Substance Use Factors Associated With Unwanted Sexual Contact Among U.S. Active Duty Service Women.

    PubMed

    Stahlman, Shauna; Javanbakht, Marjan; Cochran, Susan; Hamilton, Alison B; Shoptaw, Steven; Gorbach, Pamina M

    2015-06-01

    Many U.S. military women are exposed to unwanted sexual contact during military service, which can have important implications for mental health. Using data from the 2008 Department of Defense Survey of Health Related Behaviors, we employed multiple logistic regression methods to examine whether unwanted sexual contact was associated with stress, screening positive for mental disorders, or substance use, among active duty service women. The sample included 7,415 female military personnel, of whom 13.4% reported unwanted sexual contact (including any touching of genitals) since entering the military. After adjusting for potentially confounding variables, factors independently associated with unwanted sexual contact included military-related stress (adjusted odds ratio [AOR] = 2.44), family/personal life-related stress (AOR = 1.78), and gender-related stress (AOR = 1.98) in the past 12 months. In addition, screening positive for depression, anxiety, posttraumatic stress disorder, or psychological distress, and suicidal ideation or attempt were associated with unwanted sexual contact (AOR = 1.57-2.11). For drug/alcohol use, only misuse of tranquilizers/muscle relaxers (past 12 months) was associated with report of unwanted sexual contact (AOR = 1.35). Given the prevalence of unwanted sexual contact and corresponding adverse health outcomes in this sample of active duty women, strategies to create military structural/cultural changes and reduce gender-related stress and sexism are needed. PMID:25976935

  12. 24 CFR 960.204 - Denial of admission for criminal activity or drug abuse by household members.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... activity or drug abuse by household members. 960.204 Section 960.204 Housing and Urban Development... HOUSING Admission § 960.204 Denial of admission for criminal activity or drug abuse by household members. (a) Required denial of admission—(1) Persons evicted for drug-related criminal activity. The...

  13. Academic Duty.

    ERIC Educational Resources Information Center

    Kennedy, Donald

    This book by a former university president examines the state of the research university faculty, focusing on teaching and how success at teaching can be evaluated; ethical problems in reviewing the work of others, research and how it is supported; outside commitments; and research misconduct. Chapters include: "Academic Freedom, Academic Duty,"…

  14. A Monetary Repayment Model for Recoupment of the Educational Costs of Air Force Sponsored Graduate Education in Lieu of Completion of an Active Duty Service Commitment.

    ERIC Educational Resources Information Center

    Mangold, Sanford Dangler

    The study develops a model which enables the Air Force to initiate recoupment action against any officer, who is separating from active service prior to the completion of a graduate education Active Duty Service Commitment (ADSC). It is set up to determine the amount of money owed by the early existing officer, at any point in the ADSC. The…

  15. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in § 1.3(ee),...

  16. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission...

  17. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in § 1.3(ee),...

  18. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission...

  19. Supplemental genistein, quercetin, and resveratrol intake in active duty army soldiers.

    PubMed

    Sepowitz, John J; Fauser, Kristina R; Meyer, Stephanie A; Jackson, Steven J

    2015-05-01

    Previous reports indicate that the majority of U.S. Army soldiers consume dietary supplements (DSs) > 1 time/wk. However, these studies did not evaluate phytonutrient supplementation. A growing literature suggests inclusion of phytonutrients in DSs may pose a risk for toxicity, which could impact the performance of soldier duties, as well as long-term health and wellness. This study was conducted to assess and understand soldiers' motivations to consume phytonutrient-containing DSs, specifically genistein, quercetin, and resveratrol. The study was a cross-sectional, descriptive mixed-methods design using a survey and semistructured interviews. There were 436 soldiers stationed at Joint Base Lewis-McChord, Washington who completed the survey, from which 36 soldiers completed an interview. Overall, 34% of soldiers reported taking a single or multicomponent phytonutrient DS > 1 time/wk, from which 41 soldiers took >1 supplement/wk. Soldiers' reasons for use included unsure (54%), weight loss (12%), and other, unspecified (24%). The majority of interviewees did not consume DSs based on inclusion of genistein, quercetin, or resveratrol. The majority of soldiers, in our study, appear unable to rationalize their phytonutrient DS choices. Findings from this study illuminate the need for future research to further explore DS practices within military populations and encourage informed use of DSs. PMID:25939109

  20. Suicide Deaths of Active Duty U.S. Military and Omega-3 Fatty Acid Status: A Case Control Comparison

    PubMed Central

    Lewis, Michael D.; Hibbeln, Joseph R.; Johnson, Jeremiah E.; Lin, Yu Hong; Hyun, Duk Y.; Loewke, James D.

    2011-01-01

    Background The recent escalation of US Military suicide deaths to record numbers has been an sentinel for impaired force efficacy and has accelerated the search for reversible risk factors. Objective Determine if deficiencies of neuroactive highly unsaturated omega-3 essential fatty acids (n-3 HUFA), in particular docosahexaenoic acid (DHA), are associated with increased risk of suicide death among a large random sample of active duty US military. Methods Serum fatty acids were quantified as % of total fatty acids, among US military suicide deaths (n= 800) and controls (n=800) matched for age, date of collection, sex, rank and year of incident. Participants were Active Duty US Military personnel (2002–2008). Outcome measures, included death by suicide, post deployment health assessment questionnaire and ICD-9 mental health diagnosis data. Results Risks of suicide death was 14% higher, per standard deviation [SD] lower DHA % (OR =1.14, 95% CI; 1.02–1.27, p<0.03), in adjusted logistic regressions. Among men risk of suicide death was 62% greater with low serum DHA status (adjusted Odds Ratio [OR] =1.62, 95% CI 1.12–2.34, p<0.01, comparing DHA below 1.75% [n=1,389] to above [n=141]). Risk of suicide death was 54% greater in those who reported having seen wounded, dead or killed coalition personnel (OR = 1.54, 95% CI; 1.12–2.12, p< 0.007.) Conclusion This US military population had a very low and narrow range of n-3 HUFA status. Although these data suggest that low serum DHA may be a risk factor for suicides, well designed intervention trials are needed to evaluate causality. PMID:21903029

  1. [Health duties].

    PubMed

    Aron, Emile

    2004-01-01

    The French law dated March 4th, 2002, on patients' rights and the efficiency of the French health care system, astonished many health professionals, who have always considered patients' rights a duty. It would have been preferable to underline the fact that health preservation is first and foremost a social question based on preventive medicine. Prevention is the future of medicine, but can only expand when it is fully accepted by the population and by health professionals. We deeply regret that preventive medicine takes so little place in an official document aiming to improve the efficiency of health care. Worse, this law totally overlooks the responsibilities of patients, many of who currently jeopardize their own health and life expectancy with total impunity. Are not laws built on the twin foundations of duty and responsibility? PMID:15368930

  2. Analysis of the key active subsites of glycoside hydrolase 13 family members.

    PubMed

    Kumar, Vikash

    2010-05-01

    alpha-Amylase, pullulanase, neopullulanase, cyclomaltodextrinase (CDase), cyclomaltodextin glucanotransferase (CGTase), etc. are some of the amylolytic enzymes that act on polysaccharides. These enzymes differ from each other with respect to substrate and linkage specificities. These enzymes have been grouped into the GH13 (GH, Glycoside Hydrolase) family in the CAZy database on the basis of similarity in amino acid sequence. Members of this family share three domains viz., A, B, and C, which have several binding subsites to accommodate monomeric units of the polysaccharide substrate. Among these subsites, -2, -1, +1, and +2 subsites are the most critical subsites for catalytic activity. In the present study, the substrate analog-, inhibitor-, or product-bound 3-D structures of 24 members of GH13 family have been analyzed to identify the features of the -2, -1, +1, and +2 subsites shared by all the members for recognition of the common substrate. It is found that neither the number nor the nature of the potential hydrogen bond-forming residues is conserved with the exception of the presence of tyrosine as a stacking residue in the -1 subsite. The relative spatial disposition of the conserved subsite residues are conserved as judged by distance matrices. The backbone of the -2, -1, +1, and +2 subsites does not undergo conformational change for the recognition of the substrate. This analysis suggests that these enzymes recognize their substrate on the basis of shape of the substrate rather than on the basis of specific interactions within the binding site. PMID:20227065

  3. The Effect of Career Assessments and Follow-Up Counseling on Career Decision-Making Self-Efficacy (CDMSE) among Active-Duty Coast Guard Personnel

    ERIC Educational Resources Information Center

    Brennan, Michael D.

    2009-01-01

    This study (a) examined career decision-making self-efficacy (CDMSE) differences across gender, age, military grade, level of education, previous career assessments, previous career counseling, and currently attending college, and (b) examined the effect of career assessments with follow-up counseling on CDMSE among active-duty Coast Guard…

  4. Pilot Study to determine interest of adult civilian dependants of active duty military personnel in participation in a weight control program

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Adult civilian dependents of active duty military personnel (ADMP) may play a central role in influencing the home food environment and the risk of overweight and obesity in American Warfighters and military families. However, there is no information on whether this group would be receptive to weigh...

  5. Fatty Acid Blood Levels, Vitamin D Status, Physical Performance, Activity, and Resiliency: A Novel Potential Screening Tool for Depressed Mood in Active Duty Soldiers.

    PubMed

    Barringer, Nicholas D; Kotwal, Russ S; Lewis, Michael D; Funderburk, Leslee K; Elliott, Timothy R; Crouse, Stephen F; Smith, Stephen B; Greenwood, Michael; Kreider, Richard B

    2016-09-01

    This study examined whether blood fatty acid levels, vitamin D status, and/or physical activity are associated with physical fitness scores; a measure of mood, Patient Health Questionnaire-9; and a measure of resiliency, Dispositional Resiliency Scale-15 in active duty Soldiers. 100 active duty males at Fort Hood, Texas, underwent a battery of psychometric tests, anthropometric measurements, and fitness tests, and they also provided fasting blood samples for fatty acid and vitamin D analysis. Pearson bivariate correlation analysis revealed significant correlations among psychometric tests, anthropometric measurements, physical performance, reported physical inactivity (sitting time), and fatty acid and vitamin D blood levels. On the basis of these findings, a regression equation was developed to predict a depressed mood status as determined by the Patient Health Questionnaire-9. The equation accurately predicted depressed mood status in 80% of our participants with a sensitivity of 76.9% and a specificity of 80.5%. Results indicate that the use of a regression equation may be helpful in identifying Soldiers at higher risk for mental health issues. Future studies should evaluate the impact of exercise and diet as a means of improving resiliency and reducing depressed mood in Soldiers. PMID:27612362

  6. Students Help a Teacher Called to Active Duty: What a Great Feeling to Have a Group of Students Who Are Excited and Want to Help a Teacher in Need so Many Miles from Home

    ERIC Educational Resources Information Center

    Yuill, Ron

    2005-01-01

    The author shares how his technology education students at Tecumseh Middle School help his former student from a Purdue class, Ryan Smith, who was called to active military duty. Ryan was teaching technology education at Lafayette Jefferson High School when he was called by the military in the fall of 2004 to report to active duty. Before…

  7. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

    PubMed

    Eisenbeis, C F; Singh, H; Storb, U

    1995-06-01

    The immunoglobulin light-chain gene enhancers E kappa 3', E lambda 2-4, and E lambda 3-1 contain a conserved cell type-specific composite element essential for their activities. This element binds a B cell-specific heterodimeric protein complex that consists of the Ets family member PU.1 and a second factor (NF-EM5), whose participation in the formation of the complex is dependent on the presence of DNA-bound PU.1. In this report we describe the cloning and characterization of Pip (PU.1 interaction partner), a lymphoid-specific protein that is most likely NF-EM5. As expected, the Pip protein binds the composite element only in the presence of PU.1; furthermore, the formation of this ternary complex is critically dependent on phosphorylation of PU.1 at serine-148. The Pip gene is expressed specifically in lymphoid tissues in both B- and T-cell lines. When coexpressed in NIH-3T3 cells, Pip and PU.1 function as mutually dependent transcription activators of the composite element. The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma. PMID:7797077

  8. Unpacking Faculty Engagement: The Types of Activities Faculty Members Report as Publicly Engaged Scholarship during Promotion and Tenure

    ERIC Educational Resources Information Center

    Glass, Chris R.; Doberneck, Diane M.; Schweitzer, John H.

    2011-01-01

    While a growing body of scholarship has focused on the personal, professional, and organizational factors that influence faculty members' involvement in publicly engaged scholarship, the nature and scope of faculty publicly engaged scholarship itself has remained largely unexplored. What types of activities are faculty members involved in as…

  9. Spice: a new "legal" herbal mixture abused by young active duty military personnel.

    PubMed

    Bebarta, Vikhyat S; Ramirez, Sasha; Varney, Shawn M

    2012-01-01

    Spice is an herbal mixture smoked for euphoria and mixed with synthetic cannabinoids that are undetected on urine drug screens. Spice use has increased in the military because it is considered legal and is not detected on urine drug screen. The authors describe 3 cases of Spice use in military members. Case 1: 19-year-old male presented with paranoia, agitation, and visual hallucinations after smoking the "Space" brand of Spice. Urine thin-layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) were negative. Case 2: 19-year-old female presented with sedation, amnesia, and agitation. She smoked the "Space" brand. She was alert within 3 hours of arrival. Urine GC-MS detected levorphanol. Case 3: 23-year-old male presented with delusions and paranoia. He complained of "monsters on his back." His symptoms improved in the emergency department (ED). His urine TLC and GC-MS were negative. All cases were admitted and evaluated by a toxicologist; all 3 had their history corroborated by family or friends, or with drug paraphernalia. Spice is a new herbal mixture that is increasingly used in the military. Expected effects are similar to cannabis, but may include more paranoia and hallucinations, and may differ for each brand. PMID:22489593

  10. Members of the Chloride Intracellular Ion Channel Protein Family Demonstrate Glutaredoxin-Like Enzymatic Activity

    PubMed Central

    Al Khamici, Heba; Brown, Louise J.; Hossain, Khondker R.; Hudson, Amanda L.; Sinclair-Burton, Alxcia A.; Ng, Jane Phui Mun; Daniel, Elizabeth L.; Hare, Joanna E.; Cornell, Bruce A.; Curmi, Paul M. G.; Davey, Mary W.; Valenzuela, Stella M.

    2015-01-01

    The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins where they function as chloride selective ion channels, however no function has previously been assigned to their soluble form. Structural studies have shown that in the soluble form, CLIC proteins adopt a glutathione S-transferase (GST) fold, however, they have an active site with a conserved glutaredoxin monothiol motif, similar to the omega class GSTs. We demonstrate that CLIC proteins have glutaredoxin-like glutathione-dependent oxidoreductase enzymatic activity. CLICs 1, 2 and 4 demonstrate typical glutaredoxin-like activity using 2-hydroxyethyl disulfide as a substrate. Mutagenesis experiments identify cysteine 24 as the catalytic cysteine residue in CLIC1, which is consistent with its structure. CLIC1 was shown to reduce sodium selenite and dehydroascorbate in a glutathione-dependent manner. Previous electrophysiological studies have shown that the drugs IAA-94 and A9C specifically block CLIC channel activity. These same compounds inhibit CLIC1 oxidoreductase activity. This work for the first time assigns a functional activity to the soluble form of the CLIC proteins. Our results demonstrate that the soluble form of the CLIC proteins has an enzymatic activity that is distinct from the channel activity of their integral membrane form. This CLIC enzymatic activity may be important for protecting the intracellular environment against oxidation. It is also likely that this enzymatic activity regulates the CLIC ion channel function. PMID:25581026

  11. 14 CFR 117.17 - Flight duty period: Augmented flightcrew.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... minutes. (2) The applicable flight duty period is based on the local time at the theater in which the... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight duty period: Augmented flightcrew... FLIGHT AND DUTY LIMITATIONS AND REST REQUIREMENTS: FLIGHTCREW MEMBERS (EFF. 1-4-14) § 117.17 Flight...

  12. Novel triphosphate phosphohydrolase activity of Clostridium thermocellum TTM, a member of the triphosphate tunnel metalloenzyme superfamily.

    PubMed

    Keppetipola, Niroshika; Jain, Ruchi; Shuman, Stewart

    2007-04-20

    Triphosphate tunnel metalloenzymes (TTMs) are a newly recognized superfamily of phosphotransferases defined by a unique active site residing within an eight-stranded beta barrel. The prototypical members are the eukaryal metal-dependent RNA triphosphatases, which catalyze the initial step in mRNA capping. Little is known about the activities and substrate specificities of the scores of TTM homologs present in bacterial and archaeal proteomes, nearly all of which are annotated as adenylate cyclases. Here we have conducted a biochemical and structure-function analysis of a TTM protein (CthTTM) from the bacterium Clostridium thermocellum. CthTTM is a metal-dependent tripolyphosphatase and nucleoside triphosphatase; it is not an adenylate cyclase. We have identified 11 conserved amino acids in the tunnel that are critical for tripolyphosphatase and ATPase activity. The most salient findings are that (i) CthTTM is 150-fold more active in cleaving tripolyphosphate than ATP and (ii) the substrate specificity of CthTTM can be transformed by a single mutation (K8A) that abolishes tripolyphosphatase activity while strongly stimulating ATP hydrolysis. Our results underscore the plasticity of CthTTM substrate choice and suggest how novel specificities within the TTM superfamily might evolve through changes in the residues that line the tunnel walls. PMID:17303560

  13. Rates of ankle and foot injuries in active-duty U.S. Army soldiers, 2000-2006.

    PubMed

    Wallace, Robert F; Wahi, Monika M; Hill, Owen T; Kay, Ashley B

    2011-03-01

    Ankle and foot injuries (AFI) are a major cause of Active-Duty Army (ADA) soldiers' time lost from training and combat operations. We used the Total Army Injury and Health Outcomes Database to compute the rates of AFI to identify high-risk ADA groups for the years 2000-2006. During this time, 16% of soldiers were clinically seen at least once for an AFI. Yearly, 60% to 70% of ADA soldiers with AFI had an ankle sprain/strain, and ankle sprain/strain had the highest 7-year rate of all AFIs (103 per 1,000). From 2000 to 2006, all AFI rates declined; however, enlisted male soldiers < or = 30 years of age without an advanced degree were at highest risk. A history of an AFI in the previous 2 years increased AFI rates by 93% to 160%. Our findings provide preliminary evidence for identifying specific ADA groups at high risk of AFI; these groups should be targeted for preventive interventions. PMID:21456354

  14. Active-Duty Physicians' Perceptions and Satisfaction with Humanitarian Assistance and Disaster Relief Missions: Implications for the Field

    PubMed Central

    Oravec, Geoffrey J.; Artino, Anthony R.; Hickey, Patrick W.

    2013-01-01

    Background The United States Department of Defense participates in more than 500 missions every year, including humanitarian assistance and disaster relief, as part of medical stability operations. This study assessed perceptions of active-duty physicians regarding these activities and related these findings to the retention and overall satisfaction of healthcare professionals. Methods and Findings An Internet-based survey was developed and validated. Of the 667 physicians who responded to the survey, 47% had participated in at least one mission. On a 7-point, Likert-type response scale, physicians reported favorable overall satisfaction with their participation in these missions (mean  = 5.74). Perceived benefit was greatest for the United States (mean  = 5.56) and self (mean  = 5.39) compared to the target population (mean  = 4.82). These perceptions were related to participants' intentions to extend their military medical service (total model R2  = .37), with the strongest predictors being perceived benefit to self (β = .21, p<.01), the U.S. (β = .19, p<.01), and satisfaction (β = .18, p<.05). In addition, Air Force physicians reported higher levels of satisfaction (mean  = 6.10) than either Army (mean  = 5.27, Cohen's d = 0.75, p<.001) or Navy (mean  = 5.60, Cohen's d  = 0.46, p<.01) physicians. Conclusions Military physicians are largely satisfied with humanitarian missions, reporting the greatest benefit of such activities for themselves and the United States. Elucidation of factors that may increase the perceived benefit to the target populations is warranted. Satisfaction and perceived benefits of humanitarian missions were positively correlated with intentions to extend time in service. These findings could inform the larger humanitarian community as well as military medical practices for both recruiting and retaining medical professionals. PMID:23555564

  15. Anoctamin/TMEM16 family members are Ca2+-activated Cl− channels

    PubMed Central

    Hartzell, H Criss; Yu, Kuai; Xiao, Qinhuan; Chien, Li-Ting; Qu, Zhiqiang

    2009-01-01

    Ca2+-activated Cl− channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects. PMID:19015192

  16. Synthesis and structure-activity relationship of vicenistatin, a cytotoxic 20-membered macrolactam glycoside.

    PubMed

    Fukuda, Hayato; Nishiyama, Yuko; Nakamura, Shiina; Ohno, Yutaro; Eguchi, Tadashi; Iwabuchi, Yoshiharu; Usui, Takeo; Kanoh, Naoki

    2012-12-01

    We have developed two syntheses of vicenistatin and its analogues. Our first-generation strategy included the rapid and sequential assembly of the macrocyclic lactam by using an intermolecular Horner-Wadsworth-Emmons reaction between the C3-C13 fragment and the C1-C2, C14-C19 fragment, followed by an intramolecular Stille coupling reaction. The second-generation strategy utilized a ring-closing metathesis of a hexaene intermediate to generate the desired 20-membered macrolactam. This second-generation strategy made it possible to prepare synthetic analogues of vicenistatin, including the C20- and/or C23-demethyl analogues. Evaluation of the cytotoxic effect of these analogues indicated the importance of the fixed conformation of aglycon for determining the biological activity of the vicenistatins. PMID:23015368

  17. Sport for All? Insight into Stratification and Compensation Mechanisms of Sporting Activity in the 27 European Union Member States

    ERIC Educational Resources Information Center

    Van Tuyckom, Charlotte; Scheerder, Jeroen

    2010-01-01

    Physical activity is an important public health issue and the benefits of an active lifestyle in relation to well-being and health have been strongly emphasised in recent years in Europe, as well as in most parts of the world. However, previous research has shown that physical activity within Europe and its member states is stratified. The present…

  18. 14 CFR 117.5 - Fitness for duty.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Fitness for duty. 117.5 Section 117.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... REST REQUIREMENTS: FLIGHTCREW MEMBERS § 117.5 Fitness for duty. (a) Each flightcrew member must...

  19. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  20. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  1. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  2. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  3. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  4. Organizational Member Involvement in Physical Activity Coalitions across the United States: Development and Testing of a Novel Survey Instrument for Assessing Coalition Functioning

    ERIC Educational Resources Information Center

    Bornstein, Daniel B.; Pate, Russell R.; Beets, Michael W.; Saunders, Ruth P.; Blair, Steven N.

    2015-01-01

    Introduction: Coalitions are often composed of member organizations. Member involvement is thought to be associated with coalition success. No instrument currently exists for evaluating organizational member involvement in physical activity coalitions. This study aimed to develop a survey instrument for evaluating organizational member involvement…

  5. Transitioning New Board of Directors Members from Peripheral Roles to Active Leadership Roles

    ERIC Educational Resources Information Center

    Ostos, Ray A.

    2013-01-01

    The National Association of Community College Teacher Education Programs (NACCTEP) was established to promote the community college role in the recruitment, preparation, retention, and renewal of teachers. NACCTEP is led by a 13-member executive board consisting of community college teacher education administrators and faculty members from across…

  6. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity

    PubMed Central

    Duquette, Mark; Nadler, Monica; Okuhara, Dayne; Thompson, Jill; Shuttleworth, Trevor; Lawler, Jack

    2015-01-01

    The thrombospondins (TSPs) are a family of matricellular proteins that regulate cellular phenotype through interactions with a myriad of other proteins and proteoglycans. We have identified a novel interaction of the members of the TSP gene family with stromal interaction molecule 1 (STIM1). This association is robust since it is preserved in Triton X-100, can be detected with multiple anti-TSP-1 and anti-STIM1 antibodies, and is detected in a wide range of cell types. We have also found that STIM1 co-immunoprecipitates with TSP-4 and cartilage oligomeric matrix protein (COMP), and that a recombinant version of the N-terminal domain of STIM1 binds to the signature domain of TSP-1 and COMP. The association of the TSPs with STIM1 is observed in both the presence and absence of calcium indicating that the calcium-dependent conformation of the signature domain of TSPs is not required for binding. Thus, this interaction could occur in the ER under conditions of normal or low calcium concentration. Furthermore, we observed that the expression of COMP in HEK 293 cells decreases STIM1-mediated calcium release activated calcium (CRAC) channel currents and increases arachidonic acid calcium (ARC) channel currents. These data indicate that the TSPs regulate STIM1 function and participate in the reciprocal regulation of two channels that mediate calcium entry into the cell. PMID:24845346

  7. Incidence of joint replacement among active component service members, U.S. Armed Forces, 2004-2014.

    PubMed

    Daniele, Denise O; Taubman, Stephen B; Clark, Leslie L

    2015-05-01

    In the U.S., joint replacements have become more common and the average age of individuals who undergo joint replacements has decreased. Joint replacements among active component service members increased 10.5% during 2004-2009, then 61.9% during 2009-2014. Knees and hips were the most frequently replaced joints among service members. During the surveillance period (and particularly after 2009), incidence rates increased in each age group of service members 30 years or older. Relative to their respective counterparts, rates of joint replacement overall--and of the hip and knee specifically--were higher among service members who were black, non-Hispanic; officers; and healthcare workers. One year after joint replacement, 18.2% had retired; 5.2% had been medically disqualified from service; 6.3% had otherwise left service; and 70.3% were still in service. By 2 years post-joint replacement, 30.2% had retired; 13.0% had been medically disqualified; 10.0% had otherwise left service; and 46.8% were still in service. Service members aged 30-44 years were the most likely to remain in service post-joint replacement. Given the increases in the frequency of joint replacement among younger service members, the number of service members who remain in service post-joint replacement may continue to increase. PMID:25996170

  8. 8 CFR 329.5 - Natives of the Philippines with active duty service during World War II.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... service during World War II. 329.5 Section 329.5 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY... DUTY SERVICE IN THE UNITED STATES ARMED FORCES DURING SPECIFIED PERIODS OF HOSTILITIES § 329.5 Natives... Philippines; (2) Police clearance for any place of residence for more than six months in the previous 5...

  9. GapIII, a new brain-enriched member of the GTPase-activating protein family.

    PubMed

    Baba, H; Fuss, B; Urano, J; Poullet, P; Watson, J B; Tamanoi, F; Macklin, W B

    1995-08-15

    Ras GTPase-activating proteins (GAPs) are negative regulators of ras, which controls proliferation and differentiation in many cells. Ras GAPs have been found in a variety of species from yeast to mammals. We describe here a newly identified mammalian GAP, GapIII, which was obtained by differential screening of a rat oligodendrocyte cDNA library. GapIII putatively encodes a 834 amino acid protein with a predicted molecular weight of 96 kDa, which contains a consensus GAP-related domain (GRD). The protein encoded by this cDNA has high homology with Gap1m, which was recently identified as a putative mammalian homolog of Drosophila Gap1. These proteins contain three structural domains, an N-terminal calcium-dependent phospholipid binding domain, GRD, and a C-terminal PH/Btk domain. Because of the sequence homology and the structural similarities of this protein with Gap1m, we hypothesize that GapIII and Gap1m may be members of a mammalian GAP gene family, separate from p120GAP, neurofibromin (NF1), and IQGAP. To confirm the GapIII protein activity, constructs containing different GapIII-GRD domains were transformed into iral mutant yeast to determine their relative ability to replace IRA1 functionally. Constructs that contained essentially the full-length protein (all three domains), the GRD alone, or the GRD plus PH/Btk domain suppressed heat shock sensitivity of ira1, whereas constructs that contained the GRD with part of the PH/Btk domain had only a weak ability to suppress heat shock sensitivity. These results suggest that the GapIII GRD itself is sufficient to down-regulate ras proteins in yeast. Expression of GapIII mRNA (4.2 kb) was examined by Northern analysis and in situ hybridization. This mRNA was expressed at highest levels in the brain, where its expression increased with development. Lower levels of the mRNA were expressed in the spleen and lung. Among neural cells, GapIII mRNA was expressed in neurons and oligodendrocytes, but not in astrocytes

  10. 24 CFR 960.204 - Denial of admission for criminal activity or drug abuse by household members.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Denial of admission for criminal activity or drug abuse by household members. 960.204 Section 960.204 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING...

  11. A Beach and Dune Community. 4-H Marine Science. Member's Guide. Activity I. MSp 1.

    ERIC Educational Resources Information Center

    Auburn Univ., AL. Cooperative Extension Service.

    The investigation in this booklet is designed to provide 4-H members with opportunities to identify common plants and animals found on beaches and sand dunes and to determine the role of the plants and animals in this community. Learners are provided with a picture of a hypothetical beach and sand dune and a list of organisms (included in the…

  12. Approaches for analyzing the differential activities and functions of eIF4E family members.

    PubMed

    Rhoads, Robert E; Dinkova, Tzvetanka D; Jagus, Rosemary

    2007-01-01

    The translational initiation factor eIF4E binds to the m(7)G-containing cap of mRNA and participates in recruitment of mRNA to ribosomes for protein synthesis. eIF4E also functions in nucleocytoplasmic transport of mRNA, sequestration of mRNA in a nontranslatable state, and stabilization of mRNA against decay in the cytosol. Multiple eIF4E family members have been identified in a wide range of organisms that includes plants, flies, mammals, frogs, birds, nematodes, fish, and various protists. This chapter reviews methods that have been applied to learn the biochemical properties and physiological functions that differentiate eIF4E family members within a given organism. Much has been learned to date about approaches to discover new eIF4E family members, their in vitro properties (cap binding, stimulation of cell-free translation systems), tissue and developmental expression patterns, protein-binding partners, and their effects on the translation or repression of specific subsets of mRNA. Despite these advances, new eIF4E family members continue to be found and new physiological roles discovered. PMID:17913628

  13. Duty Calls.

    ERIC Educational Resources Information Center

    Boyer, Ernest L.

    1996-01-01

    Examines the importance of elementary and secondary student participation in community service activities for effective civic education and citizen development. Suggests that if commitment to service were an integral part of educational processes students would continue participating in community service programs as adults. (MAB)

  14. National Guard service members' perceptions of informal and formal supports: an exploratory study.

    PubMed

    Reedy, Amanda R; Kobayashi, Rie

    2015-01-01

    Much of the research on military families has focused on active duty service members. Little is known about informal and formal supports that National Guard service members use. Using an ecological systems perspective, this exploratory pilot study assessed awareness, access, use, satisfaction, and perceptions of effectiveness of informal and formal supports in a small group of National Guard service members. Results indicate that although service members are aware of many formal and informal supports, use of many of the supports is limited. Additionally, satisfaction and perceptions of effectiveness of many supports is neutral. The implications of these results are discussed. PMID:25671306

  15. Work activity of persons working as members of advisory committees established under the Federal Advisory Committee Act (FACA). Final rule.

    PubMed

    2006-01-20

    We are revising our disability regulations under titles II and XVI of the Social Security Act to establish a new, special rule that affects individuals who are receiving payments or providing services as members or consultants of a committee, board, commission, council or similar group established under the Federal Advisory Committee Act (FACA). Under this special rule, we will not count any earnings an individual is receiving from serving as a member or consultant of a FACA advisory committee when we determine if the individual is engaging in substantial gainful activity under titles II and XVI of the Social Security Act (the Act). In addition, we will not evaluate any of the services the individual is providing as a member or consultant of the FACA advisory committee when determining if the individual has engaged in substantial gainful activity under titles II and XVI of the Act. Based on our experience with FACA advisory committees and the frequency and level of activity required by these committees, we believe that performance of activity on these committees does not demonstrate the ability to perform substantial gainful activity. We believe this to be consistent with Congress's view, as it has recognized in creating the Ticket to Work advisory committee, for example, that current disability beneficiaries should be considered for membership. This also will encourage individuals with disabilities to serve on FACA advisory committees, thereby providing the benefit of their unique perspective on policies and programs to the Federal Government. PMID:16479696

  16. 49 CFR 395.8 - Driver's record of duty status.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICE OF DRIVERS § 395.8 Driver's record of duty status. (a) Except for a private motor carrier of... connection with such duty activities shall make the driver and/or the carrier liable to prosecution. (f)...

  17. 49 CFR 395.8 - Driver's record of duty status.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICE OF DRIVERS § 395.8 Driver's record of duty status. (a) Except for a private motor carrier of... connection with such duty activities shall make the driver and/or the carrier liable to prosecution. (f)...

  18. Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members*

    PubMed Central

    Suzuki, Jun; Fujii, Toshihiro; Imao, Takeshi; Ishihara, Kenji; Kuba, Hiroshi; Nagata, Shigekazu

    2013-01-01

    Asymmetrical distribution of phospholipids between the inner and outer plasma membrane leaflets is disrupted in various biological processes. We recently identified TMEM16F, an eight-transmembrane protein, as a Ca2+-dependent phospholipid scramblase that exposes phosphatidylserine (PS) to the cell surface. In this study, we established a mouse lymphocyte cell line with a floxed allele in the TMEM16F gene. When TMEM16F was deleted, these cells failed to expose PS in response to Ca2+ ionophore, but PS exposure was elicited by Fas ligand treatment. We expressed other TMEM16 proteins in the TMEM16F−/− cells and found that not only TMEM16F, but also 16C, 16D, 16G, and 16J work as lipid scramblases with different preference to lipid substrates. On the other hand, a patch clamp analysis in 293T cells indicated that TMEM16A and 16B, but not other family members, acted as Ca2+-dependent Cl− channels. These results indicated that among 10 TMEM16 family members, 7 members could be divided into two subfamilies, Ca2+-dependent Cl− channels (16A and 16B) and Ca2+-dependent lipid scramblases (16C, 16D, 16F, 16G, and 16J). PMID:23532839

  19. Incidence of hiatal hernia in service members, active component, U.S. Armed Forces, 2005-2014.

    PubMed

    O'Donnell, Francis L; Taubman, Stephen B

    2016-08-01

    From 2005 through 2014, a total of 27,276 active component service members had incident diagnoses of hiatal hernia documented in their medical records. The overall incidence rate was 19.7 cases per 10,000 person-years (p-yrs); annual incidence rates ranged from 16.5 to 22.2 cases per 10,000 p-yrs. Rates overall increased monotonically with increasing age and were higher among Air Force and Army members, officers, and healthcare workers than their respective counterparts. During the surveillance period, the 27,276 service members who had incident diagnoses of hiatal hernia accounted for 44,092 hiatal hernia-related encounters overall (1.6 encounters per case). Among all incident cases, 235 (0.86%) had surgical repairs documented during the period. The frequency of surgical treatment of hiatal hernias among military members mirrored the low frequency in U.S. civilian practice. During 2010-2014, most surgical procedures (79%) were accomplished via laparoscopic approaches. The incidence rates of hiatal hernia diagnoses reported here likely greatly underestimate the true incidence in U.S. military populations. Reasons for the underestimates and comparisons with other populations are discussed. PMID:27602798

  20. 14 CFR 117.5 - Fitness for duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Fitness for duty. 117.5 Section 117.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... REST REQUIREMENTS: FLIGHTCREW MEMBERS (EFF. 1-4-14) § 117.5 Fitness for duty. (a) Each...

  1. 78 FR 14166 - Clarification of Flight, Duty, and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ...The FAA published a final rule on January 4, 2012, that amends the existing flight, duty and rest regulations applicable to certificate holders and their flightcrew members. Since then, the FAA has received numerous questions about the new flight, duty, and rest rule. This is a response to those...

  2. Union Members Are Community Members

    ERIC Educational Resources Information Center

    Gray, David

    2013-01-01

    Unions serve their members' interests. But union members are also community members, and their interests go well beyond increasing pay and benefits. A local union president has found that his members are best served by participating in a community-wide coalition. Providing eyeglasses to needy students, promoting healthy eating, and increasing…

  3. Characteristics of particle number and mass emissions during heavy-duty diesel truck parked active DPF regeneration in an ambient air dilution tunnel

    NASA Astrophysics Data System (ADS)

    Yoon, Seungju; Quiros, David C.; Dwyer, Harry A.; Collins, John F.; Burnitzki, Mark; Chernich, Donald; Herner, Jorn D.

    2015-12-01

    Diesel particle number and mass emissions were measured during parked active regeneration of diesel particulate filters (DPF) in two heavy-duty diesel trucks: one equipped with a DPF and one equipped with a DPF + SCR (selective catalytic reduction), and compliant with the 2007 and 2010 emission standards, respectively. The emission measurements were conducted using an ambient air dilution tunnel. During parked active regeneration, particulate matter (PM) mass emissions measured from a 2007 technology truck were significantly higher than the emissions from a 2010 technology truck. Particle number emissions from both trucks were dominated by nucleation mode particles having a diameter less than 50 nm; nucleation mode particles were orders of magnitude higher than accumulation mode particles having a diameter greater than 50 nm. Accumulation mode particles contributed 77.8 %-95.8 % of the 2007 truck PM mass, but only 7.3 %-28.2 % of the 2010 truck PM mass.

  4. Active member control of a precision structure with an H(infinity) performance objective

    NASA Technical Reports Server (NTRS)

    Fanson, J. L.; Chu, C.-C.; Smith, R. S.; Anderson, E. H.

    1990-01-01

    This paper addresses the noncollocated control of active structures using active structural elements. A top level architecture for active structures is presented, and issues pertaining to robust control of structures are discussed. Controllers optimized for an H sub inf performance specification are implemented on a test structure and the results are compared with analytical predictions. Directions for further research are identified.

  5. Entamoeba histolytica: a unicellular organism containing two active genes encoding for members of the TBP family.

    PubMed

    Castañon-Sanchez, Carlos Alberto; Luna-Arias, Juan Pedro; de Dios-Bravo, Ma Guadalupe; Herrera-Aguirre, Maria Esther; Olivares-Trejo, Jose J; Orozco, Esther; Hernandez, Jose Manuel

    2010-03-01

    Entamoeba histolytica is the protozoan parasite which causes human amoebiasis. In this parasite, few encoding genes for transcription factors have been cloned and characterized. The E. histolytica TATA-box binding protein (EhTBP) is the first basal transcription factor that has been studied. To continue with the identification of other members of the basal transcription machinery, we performed an in silico analysis of the E. histolytica genome and found three loci encoding for polypeptides with similarity to EhTBP. One locus has a 100% identity to the previously Ehtbp gene reported by our group. The second locus encodes for a 212 aa polypeptide that is 100% identical to residues 23-234 from EhTBP. The third one encodes for a 216 aa polypeptide of 24kDa that showed 42.6% identity and 73.7% similarity to EhTBP. This protein was named E. histolytica TBP-related factor 1 (EhTRF1). Ehtrf1 gene was expressed in bacteria and the purified 28kDa recombinant polypeptide showed the capacity to bind to TATTTAAA-box by electrophoretic mobility shift assays. K(D) values for rEhTBP and rEhTRF1 were (1.71+/-2.90)x10(-12)M and (1.12+/-0.160)x10(-11)M, respectively. Homology modeling of EhTRF1 and EhTBP revealed that, although they were very similar, they showed some differences on their surfaces. Thus, E. histolytica is a unicellular organism having two members of the TBP family. PMID:20026212

  6. The Role of Natural Support Systems in the Post-deployment Adjustment of Active Duty Military Personnel.

    PubMed

    Welsh, Janet A; Olson, Jonathan; Perkins, Daniel F; Travis, Wendy J; Ormsby, LaJuana

    2015-09-01

    This study examined the relations among three different types of naturally occurring social support (from romantic partners, friends and neighbors, and unit leaders) and three indices of service member well-being (self reports of depressive symptoms, satisfaction with military life, and perceptions of unit readiness) for service members who did and did not report negative experiences associated with military deployment. Data were drawn from the 2011 Community Assessment completed anonymously by more than 63,000 USAF personnel. Regression analyses revealed that higher levels of social support was associated with better outcomes regardless of negative deployment experiences. Evidence of moderation was also noted, with all forms of social support moderating the impact of negative deployment experiences on depressive symptoms and support from unit leaders moderating the impact of negative deployment experience on satisfaction with military life. No moderation was found for perceptions of unit readiness. Subgroup analyses revealed slightly different patterns for male and female service members, with support providing fewer moderation effects for women. These findings may have value for military leaders and mental health professionals working to harness the power of naturally occurring relationships to maximize the positive adjustment of service members and their families. Implications for practices related to re-integration of post-deployment military personnel are discussed. PMID:26148977

  7. Astronauts Crippen and Thornton stand with off-duty recreation equipment

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Two members of a three-man SMEAT crew who will spend up to 56 days in an altitude test chamber at the NASA Manned Spacecraft Center (MSC), give a preview of their activity in this training exercise. Astronauts Robert L. Crippen, left, Skylab Medical Experiment Altitude Test (SMEAT) crew commander, and Dr. William E. Thornton, SMEAT science pilot, stand at the cabinet containing off duty recreation equipment.

  8. The Willingness of Military Members to Seek Help: The Role of Social Involvement and Social Responsibility.

    PubMed

    Bowen, Gary L; Jensen, Todd M; Martin, James A; Mancini, Jay A

    2016-03-01

    Anchored in the social organization theory of action and change, we use data from a large sample of active-duty Air Force members to examine the direct and indirect influence of social involvement and social responsibility on willingness to seek help in times of need via trust in formal systems and informal supports. Group comparisons are conducted between junior male, junior female, senior male, and senior female service members. The key mediational path in the model for all groups is the connection between social involvement and willingness to seek help via trust in formal systems. These results can inform both unit- and community-level interventions intended to increase the likelihood that active-duty AF members will seek help in times of need. PMID:27217323

  9. Group Member or Outsider: Perceptions of Undergraduates with Disabilities on Leisure Time Physical Activity

    ERIC Educational Resources Information Center

    Devine, Mary Ann

    2013-01-01

    College provides students with many opportunities to achieve academic success and enrich other aspects of their lives. Participating in campus activities can reduce stress, create social connections, promote healthy active living, and broaden civic engagement (Lindsey & Sessoms, 2006; Watson, Ayers, Zizzi, & Naoi, 2006). Studies noting…

  10. 14 CFR 117.15 - Flight duty period: Split duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... opportunity to sleep) in a suitable accommodation during his or her flight duty period, the time that the... of the flight duty period has been completed. (f) The combined time of the flight duty period and the... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight duty period: Split duty....

  11. A lepidopteran pacifastin member: cloning, gene structure, recombinant production, transcript profiling and in vitro activity.

    PubMed

    Breugelmans, Bert; Simonet, Gert; van Hoef, Vincent; Van Soest, Sofie; Smagghe, Guy; Vanden Broeck, Jozef

    2009-07-01

    Members of the pacifastin family have been characterized as serine peptidase inhibitors (PI), but their target enzyme(s) are unknown in insects. So far, the structural and biochemical characteristics of pacifastin-like PI have only been studied in locusts. Here we report the molecular identification and functional characterization of a pacifastin-like precursor in a lepidopteran insect, i.e. the silkworm Bombyx mori. The bmpp-1 gene contains 17 exons and codes for two pacifastin-related precursors of different length. The longest splice variant encodes 13 inhibitor domains, more than any other pacifastin-like precursor in arthropods. The second transcript lacks two exons and codes for 11 inhibitor domains. By studying the expression profile of the Bombyx pacifastin-like gene a different expression pattern for the two variants was observed suggesting functional diversification. Next, several PI domains of BMPP-1 were produced and, contrary to locust pacifastin peptides, they were found to be potent inhibitors of both bovine trypsin and chymotrypsin. Surprisingly, the same Bombyx PI are only weak inhibitors of endogenous digestive peptidases, indicating that other peptidases are the in vivo targets. Interestingly, the Bombyx PI inhibit a fungal trypsin-like cuticle degrading enzyme, suggesting a protective function for BMPP-1 against entomopathogenic fungi. PMID:19364530

  12. GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program

    PubMed Central

    Hopkin, Amelia Soto; Gordon, William; Klein, Rachel Herndon; Espitia, Francisco; Daily, Kenneth; Zeller, Michael; Baldi, Pierre; Andersen, Bogi

    2012-01-01

    The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes. PMID:22829784

  13. 14 CFR Table B to Part 117 - Flight Duty Period: Unaugmented Operations

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... FLIGHT AND DUTY LIMITATIONS AND REST REQUIREMENTS: FLIGHTCREW MEMBERS (EFF. 1-4-14) Pt. 117, Table B Table B to Part 117—Flight Duty Period: Unaugmented Operations Scheduled time of start (acclimated time... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight Duty Period: Unaugmented...

  14. 77 FR 20530 - Notice of Procedures for Submitting Clarifying Questions Concerning the Flight, Duty, and Rest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... published a final rule entitled, ``Flightcrew Member Duty and Rest Requirements'' (77 FR 330). In that rule... Questions Concerning the Flight, Duty, and Rest Requirements of Part 117 AGENCY: Federal Aviation... published a final rule on January 4, 2012 that amends the existing flight, duty and rest...

  15. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... activities that provide a direct, measurable benefit to an individual, a group, or a community. (d) Examples... to, the following: (1) Tutoring children in reading; (2) Helping to run an after-school program;...

  16. Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity

    PubMed Central

    Aslam, Kiran; Hazbun, Tony R.

    2016-01-01

    ABSTRACT Among different types of protein aggregation, amyloids are a biochemically well characterized state of protein aggregation that are associated with a large number of neurodegenerative diseases including Parkinson's disease, Alzheimer and Creutzfeldt-Jakob disease. Yeast, Saccharomyces cerevisiae is an insightful model to understand the underlying mechanism of protein aggregation. Many yeast molecular chaperones can modulate aggregation and misfolding of proteins including α-Syn and the Sup35 prion. Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily. An emerging view is that Hsp31 and its associated superfamily members each have divergent multitasking functions that have the common theme of responding and managing various types of cellular stress. Hsp31 has several biochemical activities including chaperone and detoxifying enzyme activities that modulate at various points of a stress pathway such as toxicity associated with protein misfolding. However, we have shown the protective role of Hsp31's chaperone activity can operate independent of detoxifying enzyme activities in preventing the early stages of protein aggregate formation and associated cellular toxicities. We provide additional data that collectively supports the multiple functional roles that can be accomplished independent of each other. We present data indicating Hsp31 purified from yeast is more active compared to expression and purification from E. coli suggesting that posttranslational modifications could be important for Hsp31 to be fully active. We also compare the similarities and differences in activities among paralogs of Hsp31 supporting a model in which this protein family has overlapping but diverging roles in responding to various sources of cellular stresses. PMID:27097320

  17. Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity.

    PubMed

    Aslam, Kiran; Hazbun, Tony R

    2016-03-01

    Among different types of protein aggregation, amyloids are a biochemically well characterized state of protein aggregation that are associated with a large number of neurodegenerative diseases including Parkinson's disease, Alzheimer and Creutzfeldt-Jakob disease. Yeast, Saccharomyces cerevisiae is an insightful model to understand the underlying mechanism of protein aggregation. Many yeast molecular chaperones can modulate aggregation and misfolding of proteins including α-Syn and the Sup35 prion. Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily. An emerging view is that Hsp31 and its associated superfamily members each have divergent multitasking functions that have the common theme of responding and managing various types of cellular stress. Hsp31 has several biochemical activities including chaperone and detoxifying enzyme activities that modulate at various points of a stress pathway such as toxicity associated with protein misfolding. However, we have shown the protective role of Hsp31's chaperone activity can operate independent of detoxifying enzyme activities in preventing the early stages of protein aggregate formation and associated cellular toxicities. We provide additional data that collectively supports the multiple functional roles that can be accomplished independent of each other. We present data indicating Hsp31 purified from yeast is more active compared to expression and purification from E. coli suggesting that posttranslational modifications could be important for Hsp31 to be fully active. We also compare the similarities and differences in activities among paralogs of Hsp31 supporting a model in which this protein family has overlapping but diverging roles in responding to various sources of cellular stresses. PMID:27097320

  18. A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase*

    PubMed Central

    Kohli, Rahul M.; Abrams, Shaun R.; Gajula, Kiran S.; Maul, Robert W.; Gearhart, Patricia J.; Stivers, James T.

    2009-01-01

    Enzymes of the AID/APOBEC family, characterized by the targeted deamination of cytosine to generate uracil within DNA, mediate numerous critical immune responses. One family member, activation-induced cytidine deaminase (AID), selectively introduces uracil into antibody variable and switch regions, promoting antibody diversity through somatic hypermutation or class switching. Other family members, including APOBEC3F and APOBEC3G, play an important role in retroviral defense by acting on viral reverse transcripts. These enzymes are distinguished from one another by targeting cytosine within different DNA sequence contexts; however, the reason for these differences is not known. Here, we report the identification of a recognition loop of 9–11 amino acids that contributes significantly to the distinct sequence motifs of individual family members. When this recognition loop is grafted from the donor APOBEC3F or 3G proteins into the acceptor scaffold of AID, the mutational signature of AID changes toward that of the donor proteins. These loop-graft mutants of AID provide useful tools for dissecting the biological impact of DNA sequence preferences upon generation of antibody diversity, and the results have implications for the evolution and specialization of the AID/APOBEC family. PMID:19561087

  19. Successful Nonoperative Management of HAGL (Humeral Avulsion of Glenohumeral Ligament) Lesion With Concurrent Axillary Nerve Injury in an Active-Duty US Navy SEAL.

    PubMed

    Ernat, Justin J; Bottoni, Craig R; Rowles, Douglas J

    2016-01-01

    Humeral avulsion of the glenohumeral ligament (HAGL) is a lesion that has been recognized as a cause of recurrent shoulder instability. To our knowledge there are no reports of successful return to full function in young, competitive athletes or return to manual labor following nonoperative management of a HAGL lesion. A 26-year-old Navy SEAL was diagnosed with a HAGL injury, and associated traction injury of the axillary nerve as well as a partial tear of the rotator cuff. Operative intervention was recommended; however, due to issues with training and with inability to properly rehab with the axillary nerve injury, surgical plans were delayed. Interestingly, the patient demonstrated both clinical and radiographic magnetic resonance imaging healing of his lesion over an 18-month period. At 18 months the patient had returned to full active duty without pain or instability as a Navy SEAL. PMID:27552458

  20. A conceptual model of the psychological health system for U.S. active duty service members: an approach to inform leadership and policy decision making.

    PubMed

    Wang, Judy Y; Glover, Wiljeana J; Rhodes, Alison M; Nightingale, Deborah

    2013-06-01

    The influence of individual-level factors such as pretraumatic risk and protective factors and the availability of unit-level and enterprise-level factors on psychological health outcomes have been previously considered individually, but have not been considered in tandem across the U.S. Military psychological health system. We use the existing literature on military psychological health to build a conceptual system dynamics model of the U.S. Military psychological health system "service-cycle" from accession and deployment to future psychological health screening and treatment. The model highlights a few key observations, challenges, and opportunities for improvement for the system that relate to several topics including the importance of modeling operational demand combined with the population's psychological health as opposed to only physical health; the role of resilience and post-traumatic growth on the mitigation of stress; the positive and negative effects of pretraumatic risk factors, unit support, and unit leadership on the service-cycle; and the opportunity to improve the system more rapidly by including more feedback mechanisms regarding the usefulness of pre- and post-traumatic innovations to medical leaders, funding authorities, and policy makers. PMID:23756065

  1. Welding Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for six occupations in the welding series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide space for…

  2. Cosmetology Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for three occupations in the cosmetology series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide…

  3. Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members.

    PubMed

    Otto, Markus; Naumann, Christin; Brandt, Wolfgang; Wasternack, Claus; Hause, Bettina

    2016-01-01

    Jasmonates (JAs) are lipid-derived signals in plant stress responses and development. A crucial step in JA biosynthesis is catalyzed by allene oxide cyclase (AOC). Four genes encoding functional AOCs (AOC1, AOC2, AOC3 and AOC4) have been characterized for Arabidopsis thaliana in terms of organ- and tissue-specific expression, mutant phenotypes, promoter activities and initial in vivo protein interaction studies suggesting functional redundancy and diversification, including first hints at enzyme activity control by protein-protein interaction. Here, these analyses were extended by detailed analysis of recombinant proteins produced in Escherichia coli. Treatment of purified AOC2 with SDS at different temperatures, chemical cross-linking experiments and protein structure analysis by molecular modelling approaches were performed. Several salt bridges between monomers and a hydrophobic core within the AOC2 trimer were identified and functionally proven by site-directed mutagenesis. The data obtained showed that AOC2 acts as a trimer. Finally, AOC activity was determined in heteromers formed by pairwise combinations of the four AOC isoforms. The highest activities were found for heteromers containing AOC4 + AOC1 and AOC4 + AOC2, respectively. All data are in line with an enzyme activity control of all four AOCs by heteromerization, thereby supporting a putative fine-tuning in JA formation by various regulatory principles. PMID:27135223

  4. Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members

    PubMed Central

    Otto, Markus; Naumann, Christin; Brandt, Wolfgang; Wasternack, Claus; Hause, Bettina

    2016-01-01

    Jasmonates (JAs) are lipid-derived signals in plant stress responses and development. A crucial step in JA biosynthesis is catalyzed by allene oxide cyclase (AOC). Four genes encoding functional AOCs (AOC1, AOC2, AOC3 and AOC4) have been characterized for Arabidopsis thaliana in terms of organ- and tissue-specific expression, mutant phenotypes, promoter activities and initial in vivo protein interaction studies suggesting functional redundancy and diversification, including first hints at enzyme activity control by protein-protein interaction. Here, these analyses were extended by detailed analysis of recombinant proteins produced in Escherichia coli. Treatment of purified AOC2 with SDS at different temperatures, chemical cross-linking experiments and protein structure analysis by molecular modelling approaches were performed. Several salt bridges between monomers and a hydrophobic core within the AOC2 trimer were identified and functionally proven by site-directed mutagenesis. The data obtained showed that AOC2 acts as a trimer. Finally, AOC activity was determined in heteromers formed by pairwise combinations of the four AOC isoforms. The highest activities were found for heteromers containing AOC4 + AOC1 and AOC4 + AOC2, respectively. All data are in line with an enzyme activity control of all four AOCs by heteromerization, thereby supporting a putative fine-tuning in JA formation by various regulatory principles. PMID:27135223

  5. Amino acids and peptides activate at least five members of the human bitter taste receptor family.

    PubMed

    Kohl, Susann; Behrens, Maik; Dunkel, Andreas; Hofmann, Thomas; Meyerhof, Wolfgang

    2013-01-01

    Amino acids and peptides represent important flavor molecules eliciting various taste sensations. Here, we present a comprehensive assessment of the interaction of various peptides and all proteinogenic amino acids with the 25 human TAS2Rs expressed in cell lines. L-Phenylalanine and L-tryptophan activate TAS2R1 and TAS2R4, respectively, whereas TAS2R4 and TAS2R39 responded to D-tryptophan. Structure-function analysis uncovered the basis for the lack of stereoselectivity of TAS2R4. The same three TAS2Rs or subsets thereof were also sensitive to various dipeptides containing L-tryptophan, L-phenylalanine, or L-leucine and to Trp-Trp-Trp, whereas Leu-Leu-Leu specifically activated TAS2R4. Trp-Trp-Trp also activated TAS2R46 and TAS2R14. Two key bitter peptides from Gouda cheese, namely, Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn-Ser and Leu-Val-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn, both activated TAS2R1 and TAS2R39. Thus, the data demonstrate that the bitterness of amino acids and peptides is not mediated by specifically tuned TAS2Rs but rather is brought about by an unexpectedly complex pattern of sensitive TAS2Rs. PMID:23214402

  6. Early Childhood Teachers' and Staff Members' Perceptions of Nutrition and Physical Activity Practices for Preschoolers

    ERIC Educational Resources Information Center

    Derscheid, Linda E.; Umoren, Josephine; Kim, So-Yeun; Henry, Beverly W.; Zittel, Lauriece L.

    2010-01-01

    Child care teachers and staff are important influences on preschoolers' nutrition and physical activity habits, and their views may be influenced by education level, years of field experience, and program involvement. For the 360 participants surveyed, responses on 5 of 18 survey items significantly differed by education level (e.g., less…

  7. Understanding Militant Teacher Union Members' Activities in Secondary Schools

    ERIC Educational Resources Information Center

    Mahlangu, Vimbi P.

    2013-01-01

    This article investigates the activities of teacher unions in some Gauteng secondary schools in South Africa. The methods used in collecting data were questionnaires, interviews and a literature study of appropriate educational and labour law journals, books and newspapers. An interpretive paradigm was used in analysing the data. In this article,…

  8. Do patients have duties?

    PubMed Central

    Evans, H M

    2007-01-01

    The notion of patients' duties has received periodic scholarly attention but remains overwhelmed by attention to the duties of healthcare professionals. In a previous paper the author argued that patients in publicly funded healthcare systems have a duty to participate in clinical research, arising from their debt to previous patients. Here the author proposes a greatly extended range of patients' duties grounding their moral force distinctively in the interests of contemporary and future patients, since medical treatment offered to one patient is always liable to be an opportunity cost (however justifiable) in terms of medical treatment needed by other patients. This generates both negative and positive duties. Ten duties—enjoining obligations ranging from participation in healthcare schemes to promoting one's own earliest recovery from illness—are proposed. The characteristics of these duties, including their basis, moral force, extent and enforceability, are considered. They are tested against a range of objections—principled, societal, epistemological and practical—and found to survive. Finally, the paper suggests that these duties could be thought to reinforce a regrettably adversarial characteristic, shared with rights‐based approaches, and that a preferable alternative might be sought through the (here unexplored) notion of a “virtuous patient” contributing to a problem‐solving partnership with the clinician. However, in defining and giving content to that partnership, there is a clear role for most, if not all, of the proposed duties; their value thus extends beyond the adversarial context in which they might first be thought to arise. PMID:18055897

  9. SLEEPLESS, a Ly–6/Neurotoxin Family Member, Regulates Levels, Localization, and Activity of Shaker

    PubMed Central

    Wu, Mark N.; Joiner, William J.; Dean, Terry; Yue, Zhifeng; Smith, Corinne J.; Chen, Dechun; Hoshi, Toshinori; Sehgal, Amita; Koh, Kyunghee

    2009-01-01

    Sleep is a whole–organism phenomenon accompanied by global changes in neural activity. We previously identified SLEEPLESS (SSS) as a novel glycosylphosphatidyl–inositol–anchored protein required for sleep in Drosophila. Here, we demonstrate a critical role for SSS in regulating the sleep–modulating potassium channel, Shaker. SSS and Shaker exhibit similar expression patterns in the brain and specifically affect each other’s expression levels. sss mutants exhibit altered Shaker localization, reduced Shaker current density, and slower Shaker current kinetics. Transgenic expression of sss in sss mutants rescues defects in Shaker expression and activity cell–autonomously and also suggests that SSS functions in wake–promoting, cholinergic neurons. Importantly, in heterologous cells, SSS accelerates kinetics of Shaker currents and can be co–immunoprecipitated with Shaker, suggesting that SSS interacts with Shaker and modulates its activity. SSS is predicted to belong to the Ly–6/neurotoxin superfamily, suggesting a novel mechanism for regulation of neuronal excitability by endogenous toxin–like molecules. PMID:20010822

  10. A new tropical active serpentinization end-member discovered in Costa Rica

    NASA Astrophysics Data System (ADS)

    Sanchez-Murillo, R.; Gazel, E.; Boll, J.; Schwarzenbach, E. M.

    2013-12-01

    Serpentinization is a planetary process where ultramafic rocks react with fluids with important consequences on global biogeochemical cycles through formation of H2 and CH4. Exposed sections of upper-mantle rocks on continents, where meteoric water interacts with the ultramafic rocks, provide natural laboratories to study present-day serpentinization. Here, we present geochemical evidence of active serpentinization and methane vents in the Santa Elena Ophiolite (comprising 250 km2 of ultramafic rocks) in Costa Rica. The system is sustained by peridotites with a 50% degree of serpentinization. Two alkaline spring systems were discovered. The alkaline fluids pH ranged from 11.01 to 11.18. Mean hydroxide and carbonate concentrations were 52 mg/L and 38 mg/L. Mean dissolved calcium was 104 mg/L with a maximum of 167 mg/L. These springs are also characterized by low Mg (< 1 mg/L) and K (2.35 mg/L) and relatively high Na (21.4 mg/L) and chloride (27.1 mg/L) concentrations. Average spring temperature was 29.1°C. Active CH4 vents (24.3% volume) coupled with extensive carbonate deposits (magnesite and calcite with isotopic compositions within the range of similar ultramafic hosted systems) also provide strong evidence of active serpentinization. Groundwater and alkaline spring's hydrological connectivity was explored using stable isotope as natural tracers. Isotope composition of the alkaline fluids (d18O = -7.9‰, d2H = -51.4‰) was remarkably similar to the groundwater signature from 10 deep wells (30-70 m) (d18O = -7.6‰; dD = -48.0‰) sampled in local watersheds. These results support the hypothesis that during prolonged dry periods these alkaline springs are fed by deep subsurface storage. Mean electrical conductivity of the alkaline fluids (622 uS/cm) was considerably higher than of surface waters (470 uS/cm); this significant difference may be additional evidence of active serpentinization in the area. Overall, Santa Elena's varying weather conditions between

  11. "We Are in This Together": Common Group Identity Predicts Majority Members' Active Acculturation Efforts to Integrate Immigrants.

    PubMed

    Kunst, Jonas R; Thomsen, Lotte; Sam, David L; Berry, John W

    2015-10-01

    Although integration involves a process of mutual accommodation, the role of majority groups is often downplayed to passive tolerance, leaving immigrants with the sole responsibility for active integration. However, we show that common group identity can actively involve majority members in this process across five studies. Study 1 showed that common identity positively predicted support of integration efforts; Studies 2 and 3 extended these findings, showing that it also predicted real behavior such as monetary donations and volunteering. A decrease in modern racism mediated the relations across these studies, and Studies 4 and 5 further demonstrated that it indeed mediated these effects over and above acculturation expectations and color-blindness, which somewhat compromised integration efforts. Moreover, the last two studies also demonstrated that common, but not dual, groups motivated integration efforts. Common identity appears crucial for securing majorities' altruistic efforts to integrate immigrants and, thus, for achieving functional multiculturalism. PMID:26276500

  12. An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities.

    PubMed

    Moss, Marcia L; Minond, Dmitriy; Yoneyama, Toshie; Hansen, Hinrich P; Vujanovic, Nikola; Rasmussen, Fred H

    2016-08-15

    A fluorescent resonance energy transfer substrate with improved sensitivity for ADAM17, -10, and -9 (where ADAM represents a disintegrin and metalloproteinase) has been designed. The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (±0.3) × 10(4) M(-1) s(-1) and 2.4 (±0.3) × 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively. The substrate is more sensitive than widely used peptides based on the precursor tumor necrosis factor-alpha (TNF-alpha) cleavage site, PEPDAB010 or Dabcyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Lys(FAM)-NH2 and Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Arg-NH2. ADAM9 also processes the new peptide more than 18-fold better than the TNF-alpha-based substrates. The new substrate has a unique selectivity profile because it is processed less efficiently by ADAM8 and MMP1, -2, -3, -8, -9, -12, and -14. This substrate provides a unique tool in which to assess ADAM17, -10, and -9 activities. PMID:27177841

  13. Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.

    PubMed

    Palla, A R; Piazzolla, D; Abad, M; Li, H; Dominguez, O; Schonthaler, H B; Wagner, E F; Serrano, M

    2014-05-01

    NANOG is a key transcription factor for pluripotency in embryonic stem cells. The analysis of NANOG in human cells is confounded by the presence of multiple and highly similar paralogs. In particular, there are three paralogs encoding full-length proteins, namely, NANOG1, NANOG2 and NANOGP8, and at least eight additional paralogs that do not encode full-length NANOG proteins. Here, we have examined NANOG family expression in human embryonic stem cells (hESCs) and in human cancer cell lines using a multi-NANOG PCR that amplifies the three functional paralogs and most of the non-functional ones. As anticipated, we found that hESCs express large amounts of NANOG1 and, interestingly, they also express NANOG2. In contrast, most human cancer cells tested express NANOGP8 and the non-coding paralogs NANOGP4 and NANOGP5. Notably, in some cancer cell lines, the NANOG protein levels produced by NANOGP8 are comparable to those produced by NANOG1 in pluripotent cells. Finally, we show that NANOGP8 is as active as NANOG1 in the reprogramming of human and murine fibroblasts into induced pluripotent stem cells. These results show that cancer-associated NANOGP8 can contribute to promote de-differentiation and/or cellular plasticity. PMID:23752184

  14. A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity.

    PubMed

    Mancuso, Raffaella; Raut, Dnyaneshwar S; Marino, Nadia; De Luca, Giorgio; Giordano, Cinzia; Catalano, Stefania; Barone, Ines; Andò, Sebastiano; Gabriele, Bartolo

    2016-02-24

    The reactivity of 2-(2-alkynylphenoxy)anilines under PdI2 /KI-catalyzed oxidative carbonylation conditions has been studied. Although a different reaction pathway could have been operating, N-palladation followed by CO insertion was the favored pathway with all substrates tested, including those containing an internal or terminal triple bond. This led to the formation of a carbamoylpalladium species, the fate of which, as predicted by theoretical calculations, strongly depended on the nature of the substituent on the triple bond. In particular, 8-endo-dig cyclization preferentially occurred when the triple bond was terminal, leading to the formation of carbonylated ζ-lactam derivatives, the structures of which have been confirmed by XRD analysis. These novel medium-sized heterocyclic compounds showed antitumor activity against both estrogen receptor-positive (MCF-7) and triple negative (MDA-MB-231) breast cancer cell lines. In particular, ζ-lactam 3 j' may represent a novel and promising antitumor agent because biological tests clearly demonstrate that this compound significantly reduces cell viability and motility in both MCF-7 and MDA-MB-231 breast cancer cell lines, without affecting normal breast epithelial cell viability. PMID:26821986

  15. DEVELOPMENT WORK FOR IMPROVED HEAVY-DUTY VEHICLE MODELING CAPABILITY DATA MINING--FHWA DATASETS

    EPA Science Inventory

    A heavy-duty vehicle can produce 10 to 100 times the emissions (of NOx and PM emissions especially) of a light-duty vehicle, so heavy-duty vehicle activity needs to be well characterized. Key uncertainties with the use of MOBILE6 regarding heavy-duty vehicle emissions include th...

  16. Neck and shoulder muscle activity and posture among helicopter pilots and crew-members during military helicopter flight.

    PubMed

    Murray, Mike; Lange, Britt; Chreiteh, Shadi Samir; Olsen, Henrik Baare; Nørnberg, Bo Riebeling; Boyle, Eleanor; Søgaard, Karen; Sjøgaard, Gisela

    2016-04-01

    Neck pain among helicopter pilots and crew-members is common. This study quantified the physical workload on neck and shoulder muscles using electromyography (EMG) measures during helicopter flight. Nine standardized sorties were performed, encompassing: cruising from location A to location B (AB) and performing search and rescue (SAR). SAR was performed with Night Vision Goggles (NVG), while AB was performed with (AB+NVG) and without NVG (AB-NVG). EMG was recorded for: trapezius (TRA), upper neck extensors (UNE), and sternocleido-mastoid (SCM). Maximal voluntary contractions (MVC) were performed for normalization of EMG (MVE). Neck posture of pilots and crew-members was monitored and pain intensity of neck, shoulder, and back was recorded. Mean muscle activity for UNE was ∼10% MVE and significantly higher than TRA and SCM, and SCM was significantly lower than TRA. There was no significant difference between AB-NVG and AB+NVG. Muscle activity in the UNE was significantly higher during SAR+NVG than AB-NVG. Sortie time (%) with non-neutral neck posture for SAR+NVG and AB-NVG was: 80.4%, 74.5% (flexed), 55.5%, 47.9% (rotated), 4.5%, 3.7% (lateral flexed). Neck pain intensity increased significantly from pre- (0.7±1.3) to post-sortie (1.6±1.9) for pilots (p=0.028). If sustained, UNE activity of ∼10% MVE is high, and implies a risk for neck disorders. PMID:26852114

  17. Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation

    PubMed Central

    Brauchle, Michael; Yao, Zhiping; Arora, Rishi; Thigale, Sachin; Clay, Ieuan; Inverardi, Bruno; Fletcher, Joy; Taslimi, Paul; Acker, Michael G.; Gerrits, Bertran; Voshol, Johannes; Bauer, Andreas; Schübeler, Dirk; Bouwmeester, Tewis; Ruffner, Heinz

    2013-01-01

    Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC domain-containing proteins are one class of broadly expressed enzymes catalyzing methyl group removal. However, several JmjC proteins remain uncharacterized, gaps persist in understanding substrate recognition, and the integration of JmjC proteins into signaling pathways is just emerging. The KDM3 subfamily is an evolutionarily conserved group of histone demethylase proteins, thought to share lysine substrate specificity. Here we use a systematic approach to compare KDM3 subfamily members. We show that full-length KDM3A and KDM3B are H3K9me1/2 histone demethylases whereas we fail to observe histone demethylase activity for JMJD1C using immunocytochemical and biochemical approaches. Structure-function analyses revealed the importance of a single amino acid in KDM3A implicated in the catalytic activity towards H3K9me1/2 that is not conserved in JMJD1C. Moreover, we use quantitative proteomic analyses to identify subsets of the interactomes of the 3 proteins. Specific interactor candidates were identified for each of the three KDM3 subfamily members. Importantly, we find that SCAI, a known transcriptional repressor, interacts specifically with KDM3B. Taken together, we identify substantial differences in the biology of KDM3 histone demethylases, namely enzymatic activity and protein-protein interactions. Such comparative approaches pave the way to a better understanding of histone demethylase specificity and protein function at a systems level and are instrumental in identifying the more subtle differences between closely related proteins. PMID:23593242

  18. Analysis of promoter activity of members of the PECTATE LYASE-LIKE (PLL) gene family in cell separation in Arabidopsis

    PubMed Central

    2010-01-01

    Background Pectate lyases depolymerize pectins by catalyzing the eliminative cleavage of α-1,4-linked galacturonic acid. Pectate lyase-like (PLL) genes make up among the largest and most complex families in plants, but their cellular and organismal roles have not been well characterized, and the activity of these genes has been assessed only at the level of entire organs or plant parts, potentially obscuring important sub-organ or cell-type-specific activities. As a first step to understand the potential functional diversity of PLL genes in plants and specificity of individual genes, we utilized a reporter gene approach to document the spatial and temporal promoter activity for 23 of the 26 members of the Arabidopsis thaliana (Arabidopsis) PLL gene family throughout development, focusing on processes involving cell separation. Results Numerous PLL promoters directed activity in localized domains programmed for cell separation, such as the abscission zones of the sepal, petal, stamen, and seed, as well as the fruit dehiscence zone. Several drove activity in cell types expected to facilitate separation, including the style and root endodermal and cortical layers during lateral root emergence. However, PLL promoters were active in domains not obviously programmed for separation, including the stipule, hydathode and root axis. Nearly all PLL promoters showed extensive overlap of activity in most of the regions analyzed. Conclusions Our results document potential for involvement of PLL genes in numerous aspects of growth and development both dependent and independent of cell separation. Although the complexity of the PLL gene family allows for enormous potential for gene specialization through spatial or temporal regulation, the high degree of overlap of activity among the PLL promoters suggests extensive redundancy. Alternatively, functional specialization might be determined at the post-transcriptional or protein level. PMID:20649977

  19. Dissolution of bedded rock salt: A seismic profile across the active eastern margin of the Hutchinson Salt Member, central Kansas

    USGS Publications Warehouse

    Anderson, N.L.; Hopkins, J.; Martinez, A.; Knapp, R.W.; Macfarlane, P.A.; Watney, W.L.; Black, R.

    1994-01-01

    Since late Tertiary, bedded rock salt of the Permian Hutchinson Salt Member has been dissolved more-or-less continuously along its active eastern margin in central Kansas as a result of sustained contact with unconfined, undersaturated groundwater. The associated westward migration of the eastern margin has resulted in surface subsidence and the contemporaneous sedimentation of predominantly valley-filling Quarternary alluvium. In places, these alluvium deposits extend more than 25 km to the east of the present-day edge of the main body of contiguous rock salt. The margin could have receded this distance during the past several million years. From an environmental perspective, the continued leaching of the Hutchinson Salt is a major concern. This predominantly natural dissolution occurs in a broad zone across the central part of the State and adversely affects groundwater and surface-water quality as nonpoint source pollution. Significant surface subsidence occurs as well. Most of these subsidence features have formed gradually; others developed in a more catastrophic manner. The latter in particular pose real threats to roadways, railways, and buried oil and gas pipelines. In an effort to further clarify the process of natural salt dissolution in central Kansas and with the long-term goal of mitigating the adverse environmental affects of such leaching, the Kansas Geological Survey acquired a 4-km seismic profile across the eastern margin of the Hutchinson Salt in the Punkin Center area of central Kansas. The interpretation of these seismic data (and supporting surficial and borehole geologic control) is consistent with several hypotheses regarding the process and mechanisms of dissolution. More specifically these data support the theses that: 1. (1) Dissolution along the active eastern margin of the Hutchinson Salt Member was initiated during late Tertiary. Leaching has resulted in the steady westward migration of the eastern margin, surface subsidence, and the

  20. 5 CFR 734.502 - Participation in political activity while on duty, in uniform, in any room or building occupied...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to a political party convention as part of the Secretary's security or administrative detail. The... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Participation in political activity while... (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) POLITICAL ACTIVITIES OF FEDERAL EMPLOYEES...

  1. Activity in M Dwarf Members of NGC 2516 and M67: Calibrating an Age-Activity Relation

    NASA Astrophysics Data System (ADS)

    Andersen, Jan M.; West, A. A.; Covey, K. R.; McDonald, M.; Veilleux, S.; Seth, A.

    2011-05-01

    We present preliminary results from a study of M dwarf magnetic activity in clusters of known ages with the ultimate goal of constraining the age-activity relation. The age-activity relation provides clues to the mechanisms generating magnetic dynamos, especially in late-type dwarfs where their stellar interiors become fully convective. Broadband griz photometry was obtained for four clusters with ages ranging from 150 Myrs to 4 Gyrs. Narrowband images of each cluster were acquired with the Maryland Magellan Tunable Filter, tuned to the frequency of H-alpha (including a correction for each cluster's radial velocity) and a nearby, similarly sized bandpass sampling the stellar pseudo-continuum. This permits a "photometric” measurement of the H-alpha emission for each star, and thus a measure of activity. Cluster membership is determined from broadband photometry and comparison to stellar positions from previous studies. We report on our findings for the clusters NGC 2516 and M67. H-alpha measurements are stronger for cluster stars than for field stars of the same magnitude. In NGC 2516, a clear correlation is seen between our H-alpha strengths measured by narrowband imaging and previous spectroscopic activity measurements in stars for which spectra have been obtained. J.M.A. acknowledges support through an NSF Graduate Research Fellowship.

  2. Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma

    PubMed Central

    Guadagno, J; Xu, X; Karajgikar, M; Brown, A; Cregan, S P

    2013-01-01

    Neuroinflammation is a common feature of acute neurological conditions such as stroke and spinal cord injury, as well as neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Previous studies have demonstrated that acute neuroinflammation can adversely affect the survival of neural precursor cells (NPCs) and thereby limit the capacity for regeneration and repair. However, the mechanisms by which neuroinflammatory processes induce NPC death remain unclear. Microglia are key mediators of neuroinflammation and when activated to induce a pro-inflammatory state produce a number of factors that could affect NPC survival. Importantly, in the present study we demonstrate that tumor necrosis factor α (TNFα) produced by lipopolysaccharide-activated microglia is necessary and sufficient to trigger apoptosis in mouse NPCs in vitro. Furthermore, we demonstrate that microglia-derived TNFα induces NPC apoptosis via a mitochondrial pathway regulated by the Bcl-2 family protein Bax. BH3-only proteins are known to play a key role in regulating Bax activation and we demonstrate that microglia-derived TNFα induces the expression of the BH3-only family member Puma in NPCs via an NF-κB-dependent mechanism. Specifically, we show that NF-κB is activated in NPCs treated with conditioned media from activated microglia and that Puma induction and NPC apoptosis is blocked by the NF-κB inhibitor BAY-117082. Importantly, we have determined that NPC apoptosis induced by activated microglia-derived TNFα is attenuated in Puma-deficient NPCs, indicating that Puma induction is required for NPC death. Consistent with this, we demonstrate that Puma-deficient NPCs exhibit an ∼13-fold increase in survival as compared with wild-type NPCs following transplantation into the inflammatory environment of the injured spinal cord in vivo. In summary, we have identified a key signaling pathway that regulates neuroinflammation induced apoptosis

  3. Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma.

    PubMed

    Guadagno, J; Xu, X; Karajgikar, M; Brown, A; Cregan, S P

    2013-01-01

    Neuroinflammation is a common feature of acute neurological conditions such as stroke and spinal cord injury, as well as neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Previous studies have demonstrated that acute neuroinflammation can adversely affect the survival of neural precursor cells (NPCs) and thereby limit the capacity for regeneration and repair. However, the mechanisms by which neuroinflammatory processes induce NPC death remain unclear. Microglia are key mediators of neuroinflammation and when activated to induce a pro-inflammatory state produce a number of factors that could affect NPC survival. Importantly, in the present study we demonstrate that tumor necrosis factor α (TNFα) produced by lipopolysaccharide-activated microglia is necessary and sufficient to trigger apoptosis in mouse NPCs in vitro. Furthermore, we demonstrate that microglia-derived TNFα induces NPC apoptosis via a mitochondrial pathway regulated by the Bcl-2 family protein Bax. BH3-only proteins are known to play a key role in regulating Bax activation and we demonstrate that microglia-derived TNFα induces the expression of the BH3-only family member Puma in NPCs via an NF-κB-dependent mechanism. Specifically, we show that NF-κB is activated in NPCs treated with conditioned media from activated microglia and that Puma induction and NPC apoptosis is blocked by the NF-κB inhibitor BAY-117082. Importantly, we have determined that NPC apoptosis induced by activated microglia-derived TNFα is attenuated in Puma-deficient NPCs, indicating that Puma induction is required for NPC death. Consistent with this, we demonstrate that Puma-deficient NPCs exhibit an ∼13-fold increase in survival as compared with wild-type NPCs following transplantation into the inflammatory environment of the injured spinal cord in vivo. In summary, we have identified a key signaling pathway that regulates neuroinflammation induced apoptosis

  4. New 15-membered tetraaza (N4) macrocyclic ligand and its transition metal complexes: Spectral, magnetic, thermal and anticancer activity

    NASA Astrophysics Data System (ADS)

    El-Boraey, Hanaa A.; EL-Gammal, Ohyla A.

    2015-03-01

    Novel tetraamidemacrocyclic 15-membered ligand [L] i.e. naphthyl-dibenzo[1,5,9,12]tetraazacyclopentadecine-6,10,11,15-tetraoneand its transition metal complexes with Fe(II), Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On the basis of analytical, spectral (IR, MS, UV-Vis, 1H NMR and EPR) and thermal studies distorted octahedral or square planar geometry has been proposed for the complexes. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50 = 2.27-2.7, 8.33-31.1 μg/mL, respectively) showed potent antitumor activity, towards the former cell lines comparable with their ligand (IC50 = 13, 26 μg/mL, respectively). The results show that the activity of the ligand towards breast cancer cell line becomes more pronounced and significant when coordinated to the metal ion.

  5. Member of the CREB/ATF protein family, but not CREB alpha plays an active role in BLV tax trans activation in vivo.

    PubMed Central

    Kiss-Toth, E; Paca-uccaralertkun, S; Unk, I; Boros, I

    1993-01-01

    The trans activator protein of Bovine Leukaemia Virus (tax) increases the rate of transcription from the virus promoter through 21 bp sequences located in three tandem copies in the virus LTR. Based on data obtained by three different experimental approaches we concluded that the central CRE-like motif found in each of the BLV 21 bp repeats plays an important and indispensable role in tax mediated trans activation. These include (i) in vivo analysis of the function of mutant 21 bp sequences in transient transfection, (ii) gel mobility shift assay to show that CREB binds to BLV 21 bp repeats in vitro and (iii) the demonstration that the production of antisense CREB mRNA inhibits tax trans activation. Further studies with different deletion mutant CREB proteins suggest that although CREB alpha can interact with factors involved in BLV trans activation, it does not promote transcription initiation; consequently some other member/s of the CREB/ATF family must be involved. Images PMID:8396235

  6. Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection.

    PubMed

    Barillas-Mury, C; Han, Y S; Seeley, D; Kafatos, F C

    1999-02-15

    A new insect member of the STAT family of transcription factors (Ag-STAT) has been cloned from the human malaria vector Anopheles gambiae. The domain involved in DNA interaction and the SH2 domain are well conserved. Ag-STAT is most similar to Drosophila D-STAT and to vertebrate STATs 5 and 6, constituting a proposed ancient class A of the STAT family. The mRNA is expressed at all developmental stages, and the protein is present in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells. There is no evidence of transcriptional activation following bacterial challenge. However, bacterial challenge results in nuclear translocation of Ag-STAT protein in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates Ag-STAT to the nucleus in midgut epithelial cells. This is the first evidence of direct participation of the STAT pathway in immune responses in insects. PMID:10022838

  7. Elastomeric member

    DOEpatents

    Hoppie, Lyle O.

    1985-01-01

    An energy storage device (10) is disclosed consisting of a stretched elongated elastomeric member (16) disposed within a tubular housing (14), which elastomeric member (16) is adapted to be torsionally stressed to store energy. The elastomeric member (16) is configured in the relaxed state with a uniform diameter body section (74), and transition end sections (76, 78), attached to rigid end piece assemblies (22, 24) of a lesser diameter. The profile and deflection characteristic of the transition sections (76, 78) are such that upon stretching of the elastomeric member (16), a substantially uniform diameter assembly results, to minimize the required volume of the surrounding housing (14). Each of the transition sections (76, 78) are received within and bonded to a woven wire mesh sleeve (26, 28) having helical windings at a particular helix angle to control the deflection of the transition section. Each sleeve (26, 28) also contracts with the contraction of the associated transition section to maintain the bond therebetween. During manufacture, the sleeves (26, 28) are forced against a forming surface and bonded to the associated transition section (76, 78) to provide the correct profile and helix angle.

  8. Elastomeric member

    DOEpatents

    Hoppie, L.O.

    1985-07-30

    An energy storage device is disclosed consisting of a stretched elongated elastomeric member disposed within a tubular housing, which elastomeric member is adapted to be torsionally stressed to store energy. The elastomeric member is configured in the relaxed state with a uniform diameter body section, and transition end sections, attached to rigid end piece assemblies of a lesser diameter. The profile and deflection characteristic of the transition sections are such that upon stretching of the elastomeric member, a substantially uniform diameter assembly results, to minimize the required volume of the surrounding housing. Each of the transition sections are received within and bonded to a woven wire mesh sleeve having helical windings at a particular helix angle to control the deflection of the transition section. Each sleeve also contracts with the contraction of the associated transition section to maintain the bond there between. During manufacture, the sleeves are forced against a forming surface and bonded to the associated transition section to provide the correct profile and helix angle. 12 figs.

  9. Military service absences and family members' mental health: A timeline followback assessment.

    PubMed

    Rodriguez, Aubrey J; Margolin, Gayla

    2015-08-01

    Although military service, and particularly absence due to deployment, has been linked to risk for depression and anxiety among some spouses and children of active duty service members, there is limited research to explain the heterogeneity in family members' reactions to military service stressors. The current investigation introduces the Timeline Followback Military Family Interview (TFMFI) as a clinically useful strategy to collect detailed time-linked information about the service member's absences. Two dimensions of parent absence--the extent to which absences coincide with important family events and cumulative time absent--were tested as potential risks to family members' mental health. Data from 70 mother-adolescent pairs revealed that the number of important family events missed by the service member was linked to elevated youth symptoms of depression, even when accounting for the number of deployments and cumulative duration of the service member's absence. However, youth who reported more frequent contact with the service member during absences were buffered from the effects of extensive absence. Mothers' symptoms were associated with the cumulative duration of the service members' time away, but not with family events missed by the service member. These results identify circumstances that increase the risk for mental health symptoms associated with military family life. The TFMFI provides an interview-based strategy for clinicians wishing to understand military family members' lived experience during periods of service-member absence. PMID:26075736

  10. 46 CFR 11.524 - Service requirements for national endorsement as designated duty engineer (DDE) of steam, motor...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... qualified member of the engine department or equivalent position; (2) For designated duty engineer of steam... engine department or equivalent position; and (3) For designated duty engineer of steam, motor, and/or... designated duty engineer (DDE) of steam, motor, and/or gas turbine-propelled vessels. 11.524 Section...

  11. 78 FR 27153 - Duty Periods for Establishing Eligibility for Health Care

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ...The Department of Veterans Affairs (VA) is proposing to amend its medical regulations concerning eligibility for health care to re- establish the definitions of ``active military, naval, or air service,'' ``active duty,'' and ``active duty for training.'' These definitions were deleted in 1996; however, we believe that all duty periods should be defined in part 17 of the Code of Federal......

  12. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender.

    PubMed

    Bolling, Danielle Z; Pelphrey, Kevin A; Vander Wyk, Brent C

    2016-10-01

    The effects of group membership on brain responses to social exclusion have been investigated in adults, revealing greater anterior cingulate responses to exclusion by members of one's in-group (e.g., same-gender). However, social exclusion is a critical aspect of peer relations in youth and reaches heightened salience during adolescence, a time when social anxiety disorders are also emergent. While the behavioral and neural correlates of social exclusion in adolescence have been extensively explored, the effects of group membership on peer rejection are less clear. The current study used functional magnetic resonance imaging (fMRI) to investigate the differential neural correlates of being excluded by peers of one's same- versus opposite-gender during an online ball-toss game. Participants were a group of typically developing children and adolescents (7-17 years). As predicted, anterior cingulate cortex showed a main effect of social exclusion versus fair play. However, unlike a previous adult study, this region did not show increased activation to same-gender exclusion. Instead, several regions differentiating same- versus opposite-gender exclusion were exclusively more sensitive to exclusion by one's opposite gender. These results are discussed in the context of adolescent socio-emotional development. PMID:26592311

  13. 77 FR 329 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ... likelihood of being able to sleep under different circumstances. \\6\\ 75 FR 55852; September 14, 2010. The... Clarifying Questions to the RIA'' and ``Response to Clarifying Questions to the NPRM.'' \\7\\ 75 FR 62486... decision is outlined in the October 15, 2010 action. \\8\\ 75 FR 63424; October 15, 2010. The FAA...

  14. 75 FR 62486 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... and Rest Requirements'' (75 FR 55852). The proposed regulation recognizes the growing similarities... Clarifications: Peter Ivory, Office of Aviation Policy & Plans, Federal Aviation Administration; e-mail peter.ivory@faa.gov . The FAA will reply to requests for clarification to the NPRM if submitted by October...

  15. 75 FR 63424 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ...: The comment period for the NPRM published on September 14, 2010, at 75 FR 55852, closes on November 15... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78) or you... published in the Federal Register (75 FR 55852) on September 14, 2010 for detailed instructions on...

  16. Supporting members

    NASA Astrophysics Data System (ADS)

    Life Supporting Members L. Thomas Aldrich Thomas D. Barrow Hugh J . A. Chivers Allan V. Cox Samuel S. Goldich Pembroke J. Hart A. Ivan Johnson Helmut E. Landsberg Paolo Lanzano Murli H. Manghnani L. L. Nettleton Charles B. Officer Hyman Orlin Ned A. Ostenso Erick O. Schonstedt Waldo E. Smith Athelstan Spilhaus A. F. Spilhaus, Jr. John W. Townsend, Jr. James A. Van Allen Leonard W. Weis Charles A. Whitten J. Tuzo Wilson

  17. Analysis of the active site mechanism of Tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily

    PubMed Central

    Gajewski, Stefan; Comeaux, Evan Q.; Jafari, Nauzanene; Bharatham, Nagakumar; Bashford, Donald; White, Stephen W.; van Waardenburg, Robert C.A.M.

    2011-01-01

    Tyrosyl DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily and hydrolyzes 3′phospho-DNA adducts via two conserved catalytic histidines, one acting as the lead nucleophile and the second as a general acid/base. Substitution of the second histidine specifically to arginine contributes to the neurodegenerative disease SCAN1. We investigated the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crystallography, biochemistry, yeast genetics and theoretical chemistry. The structures of wild type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn. The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts access of a nucleophilic water molecule to the Tdp1-DNA intermediate. Biochemical analyses confirm that His432Arg forms an observable and unique Tdp1-DNA adduct during catalysis. Substitution of His432 by Lys does not affect catalytic activity or yeast phenotype, but substitution with Asn, Gln, Leu, Ala, Ser and Thr all result in severely compromised enzymes and Top1-camptothecin dependent lethality. Surprisingly, His432Asn did not show a stable covalent Tdp1-DNA intermediate which suggests another catalytic defect. Theoretical calculations revealed that the defect resides in the nucleophilic histidine and that the pKa of this histidine is crucially dependent upon the second histidine and the incoming phosphate of the substrate. This represents a unique example of substrate-activated catalysis that applies to the entire phospholipase D superfamily. PMID:22155078

  18. Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily

    SciTech Connect

    Gajewski, Stefan; Comeaux, Evan Q.; Jafari, Nauzanene; Bharatham, Nagakumar; Bashford, Donald; White, Stephen W.; van Waardenburg, Robert C.A.M.

    2012-03-15

    Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines - one acting as the lead nucleophile and the second acting as a general acid/base. Substitution of the second histidine specifically to arginine contributes to the neurodegenerative disease spinocerebellar ataxia with axonal neuropathy (SCAN1). We investigated the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crystallography, biochemistry, yeast genetics, and theoretical chemistry. The structures of wild-type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn. The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts the access of nucleophilic water molecule to the Tdp1-DNA intermediate. Biochemical analyses confirm that His432Arg forms an observable and unique Tdp1-DNA adduct during catalysis. Substitution of His432 by Lys does not affect catalytic activity or yeast phenotype, but substitutions with Asn, Gln, Leu, Ala, Ser, and Thr all result in severely compromised enzymes and DNA topoisomerase I-camptothecin dependent lethality. Surprisingly, His432Asn did not show a stable covalent Tdp1-DNA intermediate that suggests another catalytic defect. Theoretical calculations revealed that the defect resides in the nucleophilic histidine and that the pK{sub a} of this histidine is crucially dependent on the second histidine and on the incoming phosphate of the substrate. This represents a unique example of substrate-activated catalysis that applies to the entire phospholipase D superfamily.

  19. Rescuing the duty to rescue.

    PubMed

    Rulli, Tina; Millum, Joseph

    2016-04-01

    Clinicians and health researchers frequently encounter opportunities to rescue people. Rescue cases can generate a moral duty to aid those in peril. As such, bioethicists have leveraged a duty to rescue for a variety of purposes. Yet, despite its broad application, the duty to rescue is underanalysed. In this paper, we assess the state of theorising about the duty to rescue. There are large gaps in bioethicists' understanding of the force, scope and justification of the two most cited duties to rescue-the individual duty of easy rescue and the institutional rule of rescue. We argue that the duty of easy rescue faces unresolved challenges regarding its force and scope, and the rule of rescue is indefensible. If the duty to rescue is to help solve ethical problems, these theoretical gaps must be addressed. We identify two further conceptions of the duty to rescue that have received less attention-an institutional duty of easy rescue and the professional duty to rescue. Both provide guidance in addressing force and scope concerns and, thereby, traction in answering the outstanding problems with the duty to rescue. We conclude by proposing research priorities for developing accounts of duties to rescue in bioethics. PMID:24790055

  20. Balancing Duties and Rights.

    ERIC Educational Resources Information Center

    McCarthy, Martha M.; Webb, L. Dean

    2000-01-01

    Schools are legally obligated to protect students from injury, report child abuse, and curtail harassment and hate crimes. Educators' duties to maintain safe school environments often conflict with students' constitutionally protected rights governing expression, appearance, unreasonable searches, and due process regarding zero-tolerance policies…

  1. 77 FR 5485 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Advance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Five-Year Sunset Reviews. Antidumping Duty Proceedings Activated Carbon From China (A-570-904) (1st... Countervailing Duty Orders; Policy Bulletin, 63 FR 18871 (April 16, 1998). The Notice of Initiation of...

  2. 45 CFR 617.4 - General duties of recipients.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false General duties of recipients. 617.4 Section 617.4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM NSF § 617.4 General duties of recipients....

  3. 45 CFR 617.4 - General duties of recipients.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false General duties of recipients. 617.4 Section 617.4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM NSF § 617.4 General duties of recipients....

  4. 45 CFR 617.4 - General duties of recipients.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false General duties of recipients. 617.4 Section 617.4 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM NSF § 617.4 General duties of recipients....

  5. 45 CFR 2520.50 - How much time may AmeriCorps members in my program spend in education and training activities?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false How much time may AmeriCorps members in my program spend in education and training activities? 2520.50 Section 2520.50 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS § 2520.50...

  6. 45 CFR 2520.50 - How much time may AmeriCorps members in my program spend in education and training activities?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false How much time may AmeriCorps members in my program spend in education and training activities? 2520.50 Section 2520.50 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS § 2520.50...

  7. Characterization of active members in C and N cycles in the subsurface environment of the Witwatersrand Basin

    NASA Astrophysics Data System (ADS)

    Lindsay, M. R.; Lau, C. M.; Tetteh, G.; Snyder, L.; Kieft, T. L.; Lollar, B. S.; Li, L.; Maphanga, S.; van Heerden, E.; Onstott, T. C.

    2012-12-01

    methanotrophs were found three times more than Type I methanotrophs. A pmoA gene sequence represents 42% of the library matches only and is identical to a putative protein sequence annotated on Ca. D. audaxviator genome, but further analysis is required to validate its candidature of methanotrophy. The cluster of mcrA gene sequences is related to a novel group of anaerobic methanotrophs (ANME) defined by environmental sequences. 2011 July samples from the same borehole revealed an absence of Firmicutes. Two β-Proteobacterial sequences dominated the bacterial 16S rDNA clone library, accounting for 54% and 25%. The first 16S rRNA clone library for the region confirmed a complete lack of Firmicutes with active Proteobacteria (71% α-, 17% β- and 6% γ-Proteobacteria). Only 3% of the active community is confidently inferred as methylotrophs while 22% belongs to N2 fixer Rhizobium sp. which has been demonstrated to stimulate methanotrophic growth and 28% is related to Polymorphum gilvum, which is known for n-alkane degradation. Active members responsible for CH4 metabolism will be supported by presenting the results of archaeal 16S rRNA, pmoA, mcrA and nitrogenase gene diversities. The lack of Firmicutes in July samples could be attributed to collection methods: different filter membrane, faster flowrate but shorter sampling duration, and less total volume of water filtered.

  8. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.

    PubMed

    Wong, Tania A; Fairn, Gregory D; Poon, Pak P; Shmulevitz, Maya; McMaster, Christopher R; Singer, Richard A; Johnston, Gerald C

    2005-09-01

    The budding yeast Saccharomyces cerevisiae contains a family of Arf (ADP-ribosylation factor) GTPase activating protein (GAP) proteins with the Gcs1 + Age2 ArfGAP pair providing essential overlapping function for the movement of transport vesicles from the trans-Golgi network. We have generated a temperature-sensitive but stable version of the Gcs1 protein that is impaired only for trans-Golgi transport and find that deleterious effects of this enfeebled Gcs1-4 mutant protein are relieved by increased gene dosage of the gcs1-4 mutant gene itself or by the SFH2 gene (also called CSR1), encoding a phosphatidylinositol transfer protein (PITP). This effect was not seen for the SEC14 gene, encoding the founding member of the yeast PITP protein family, even though the Gcs1 and Age2 ArfGAPs are known to be downstream effectors of Sec14-mediated activity for trans-Golgi transport. Sfh2-mediated suppression of inadequate Gcs1-4 function depended on phospholipase D, whereas inadequate Gcs1-4 activity was relieved by increasing levels of diacylglycerol (DAG). Recombinant Gcs1 protein was found to bind certain phospholipids but not DAG. Our findings favor a model of Gcs1 localization through binding to specific phospholipids and activation of ArfGAP activity by DAG-mediated membrane curvature as the transport vesicle is formed. Thus, ArfGAPs are subject to both temporal and spatial regulation that is facilitated by Sfh2-mediated modulation of the lipid environment. PMID:16126894

  9. Light Duty Efficient, Clean Combustion

    SciTech Connect

    Donald Stanton

    2010-12-31

    aftertreatment engine; (5) Emissions and efficiency targets were reached with the use of biodiesel. A variety of biofuel feedstocks (soy, rapeseed, etc.) was investigated; (6) The advanced LDECC engine with low temperature combustion was compatible with commercially available biofuels as evaluated by engine performance testing and not durability testing; (7) The advanced LDECC engine equipped with a novel SCR aftertreatment system is the engine system architecture that is being further developed by the Cummins product development organization. Cost reduction and system robustness activities have been identified for future deployment; (8) The new engine and aftertreatment component technologies are being developed by the Cummins Component Business units (e.g. fuel system, turbomachinery, aftertreatment, electronics, etc.) to ensure commercial viability and deployment; (9) Cummins has demonstrated that the technologies developed for this program are scalable across the complete light duty engine product offerings (2.8L to 6.7L engines); and (10) Key subsystems developed include - sequential two stage turbo, combustions system for low temperature combustion, novel SCR aftertreatment system with feedback control, and high pressure common rail fuel system. An important element of the success of this project was leveraging Cummins engine component technologies. Innovation in component technology coupled with system integration is enabling Cummins to move forward with the development of high efficiency clean diesel products with a long term goal of reaching a 40% improvement in thermal efficiency for the engine plus aftertreatment system. The 40% improvement is in-line with the current light duty vehicle efficiency targets set by the 2010 DoE Vehicle Technologies MYPP and supported through co-operative projects such as the Cummins Advanced Technology Powertrains for Light-Duty Vehicles (ATP-LD) started in 2010.

  10. 14 CFR Table C to Part 117 - Flight Duty Period: Augmented Operations

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight Duty Period: Augmented Operations C Table C to Part 117 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... LIMITATIONS AND REST REQUIREMENTS: FLIGHTCREW MEMBERS Pt. 117, Table C Table C to Part 117—Flight Duty...

  11. 29 CFR 1620.20 - Pay differentials claimed to be based on extra duties.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the higher paid sex receive the higher pay without doing the extra work; (b) Members of the lower paid sex also perform extra duties requiring equal skill, effort, and responsibility; (c) The proffered... duties may not be a defense to the payment of higher wages to one sex where the higher pay is not...

  12. 32 CFR 552.60 - Supervision of on-post commercial activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... solicitation by an active duty member of the Armed Forces of another member who is junior in rank or grade, at... company or product affiliation. (13) Use of the “Daily Bulletin” or any other notice, official, or... product that the agent represents. (16) Offering of financial benefit or other valuable or...

  13. 32 CFR 552.60 - Supervision of on-post commercial activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... solicitation by an active duty member of the Armed Forces of another member who is junior in rank or grade, at... company or product affiliation. (13) Use of the “Daily Bulletin” or any other notice, official, or... product that the agent represents. (16) Offering of financial benefit or other valuable or...

  14. 32 CFR 552.60 - Supervision of on-post commercial activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... solicitation by an active duty member of the Armed Forces of another member who is junior in rank or grade, at... company or product affiliation. (13) Use of the “Daily Bulletin” or any other notice, official, or... product that the agent represents. (16) Offering of financial benefit or other valuable or...

  15. Battery Ownership Model - Medium Duty HEV Battery Leasing & Standardization

    SciTech Connect

    Kelly, Ken; Smith, Kandler; Cosgrove, Jon; Prohaska, Robert; Pesaran, Ahmad; Paul, James; Wiseman, Marc

    2015-12-01

    Prepared for the U.S. Department of Energy, this milestone report focuses on the economics of leasing versus owning batteries for medium-duty hybrid electric vehicles as well as various battery standardization scenarios. The work described in this report was performed by members of the Energy Storage Team and the Vehicle Simulation Team in NREL's Transportation and Hydrogen Systems Center along with members of the Vehicles Analysis Team at Ricardo.

  16. Light duty utility arm

    SciTech Connect

    1998-12-01

    The Light-Duty Utility Arm (LDUA) System is a mobile, multi-axis positioning system capable of deploying tools and sensors (end effecters) inside radioactive waste tanks for tank wall inspection, waste characterization, and waste retrieval. The LDUA robotic manipulator enters a tank through existing openings (risers) in the tank dome of the underground tanks. Using various end effecters, the LDUA System is a versatile system for high-level waste tank remediation. The LDUA System provides a means to deploy tools, while increasing the technology resources available to the U.S. Department of Energy (DOE). Ongoing end effecter development will provide additional capabilities to remediate the waste tanks.

  17. Mechanistic and Bioinformatic Investigation of a Conserved Active Site Helix in α-Isopropylmalate Synthase from Mycobacterium tuberculosis, a Member of the DRE-TIM Metallolyase Superfamily

    PubMed Central

    2015-01-01

    The characterization of functionally diverse enzyme superfamilies provides the opportunity to identify evolutionarily conserved catalytic strategies, as well as amino acid substitutions responsible for the evolution of new functions or specificities. Isopropylmalate synthase (IPMS) belongs to the DRE-TIM metallolyase superfamily. Members of this superfamily share common active site elements, including a conserved active site helix and an HXH divalent metal binding motif, associated with stabilization of a common enolate anion intermediate. These common elements are overlaid by variations in active site architecture resulting in the evolution of a diverse set of reactions that include condensation, lyase/aldolase, and carboxyl transfer activities. Here, using IPMS, an integrated biochemical and bioinformatics approach has been utilized to investigate the catalytic role of residues on an active site helix that is conserved across the superfamily. The construction of a sequence similarity network for the DRE-TIM metallolyase superfamily allows for the biochemical results obtained with IPMS variants to be compared across superfamily members and within other condensation-catalyzing enzymes related to IPMS. A comparison of our results with previous biochemical data indicates an active site arginine residue (R80 in IPMS) is strictly required for activity across the superfamily, suggesting that it plays a key role in catalysis, most likely through enolate stabilization. In contrast, differential results obtained from substitution of the C-terminal residue of the helix (Q84 in IPMS) suggest that this residue plays a role in reaction specificity within the superfamily. PMID:24720347

  18. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Remuneration of members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. 31.3401(a)(1)-1 Section 31.3401(a)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) EMPLOYMENT TAXES...

  19. Resident duty hours in Canada: a survey and national statement.

    PubMed

    Masterson, Mark F; Shrichand, Pankaj; Maniate, Jerry M

    2014-01-01

    Physicians in general, and residents in particular, are adapting to duty schedules in which they have fewer continuous work hours; however, there are no Canadian guidelines on duty hours restrictions. To better inform resident duty hour policy in Canada, we set out to prepare a set of recommendations that would draw upon evidence reported in the literature and reflect the experiences of resident members of the Canadian Association of Internes and Residents (CAIR). A survey was prepared and distributed electronically to all resident members of CAIR. A total of 1796 eligible residents participated in the survey. Of those who responded, 38% (601) reported that they felt they could safely provide care for up to 16 continuous hours, and 20% (315) said that 12 continuous hours was the maximum period during which they could safely provide care (n=1592). Eighty-two percent (1316) reported their perception that the quality of care they had provided suffered because of the number of consecutive hours worked (n=1598). Only 52% (830) had received training in handover (n=1594); those who had received such training reported that it was commonly provided through informal modelling. On the basis of these data and the existing literature, CAIR recommends that resident duty hours be managed in a way that does not endanger the health of residents or patients; does not impair education; is flexible; and does not violate ethical or legal standards. Further, residents should be formally trained in handover skills and alternative duty hour models. PMID:25559388

  20. PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.

    PubMed

    Lee, Yong Hoi; Pang, Siew Wai; Tan, Kuan Onn

    2016-04-22

    PNMA2, a member of the Paraneoplastic Ma Family (PNMA), was identified through expression cloning by using anti-sera from patients with paraneoplastic disorder. Tissue expression studies showed that PNMA2 was predominantly expressed in normal human brain; however, the protein was shown to exhibit abnormal expression profile as it was found to be expressed in a number of tumour tissues obtained from paraneopalstic patients. The abnormal expression profile of PNMA2 suggests that it might play an important role in tumorigenesis; however, apart from protein expression and immunological studies, the physiological role of PNMA2 remains unclear. In order to determine potential role of PNMA2 in tumorigenesis, and its functional relationship with PNMA family members, MOAP-1 (PNMA4) and PNMA1, expression constructs encoding the respective proteins were generated for both in vitro and in vivo studies. Our investigations showed that over-expressed MOAP-1 and PNMA1 promoted apoptosis and chemo-sensitization in MCF-7 cells as evidenced by condensed nuclei and Annexin-V positive MCF-7 cells; however, the effects mediated by these proteins were significantly inhibited or abolished when co-expressed with PNMA2 in MCF-7 cells. Furthermore, co-immunoprecipitation study showed that PNMA1 and MOAP-1 failed to associate with each other but readily formed respective heterodimer with PNMA2, suggesting that PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction. PMID:27003254

  1. Residential Carpentry Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for nine occupations in the residential carpentry series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to…

  2. Fashion Merchandising Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for seven occupations in the fashion merchandising series. Each occupation is divided into 6 to 15 duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to…

  3. Diesel Mechanics Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for 11 occupations in the diesel mechanics series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide…

  4. Auto Mechanics Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for eight occupations in the auto mechanics series. Each occupation is divided into a number of duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been taught and to provide…

  5. Emergency Medical Technician Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for 12 duties in the occupation of emergency medical technician. Each duty is divided into a number of tasks. A separate page for each duty lists the task with its code number and columns to indicate whether that particular duty has been taught and to provide space for comments. The 12 duties…

  6. The Swedish duty hour enigma

    PubMed Central

    2014-01-01

    Background The Swedish resident duty hour limit is regulated by Swedish and European legal frameworks. With a maximum average of 40 working hours per week, the Swedish duty hour regulation is one of the most restrictive in the world. At the same time, the effects of resident duty hour limits have been neither debated nor researched in the Swedish context. As a result, little is known about the Swedish conceptual framework for resident duty hours, their restriction, or their outcomes: we call this “the Swedish duty hour enigma.” This situation poses a further question: How do Swedish residents themselves construct a conceptual framework for duty hour restrictions? Methods A case study was conducted at Karolinska University Hospital, Stockholm – an urban, research-intensive hospital setting. Semi-structured interviews were carried out with 34 residents currently in training in 6 specialties. The empirical data analysis relied on theoretical propositions and was conducted thematically using a pattern-matching technique. The interview guide was based on four main topics: the perceived effect of duty hour restrictions on (1) patient care, (2) resident education, (3) resident well-being, and (4) research. Results The residents did not perceive the volume of duty hours to be the main determinant of success or failure in the four contextual domains of patient care, resident education, resident well-being, and research. Instead, they emphasized resident well-being and a desire for flexibility. Conclusions According to Swedish residents’ conceptual framework on duty hours, the amount of time spent on duty is not a proxy for the quality of resident training. Instead, flexibility, organization, and scheduling of duty hours are considered to be the factors that have the greatest influence on resident well-being, quality of learning, and opportunities to attain the competence needed for independent practice. PMID:25559074

  7. Call of Duty

    ERIC Educational Resources Information Center

    Shea, Rich

    2007-01-01

    Army National Guard Sergeant James Reynolds is one of about 10,000 former and current military service members who, since 1994, have arrived in the classroom via the federal Troops to Teachers program. Reynolds, who was serving as rear gunner on a Humvee patrolling a Bosnian town, is currently teaching 6th grade students at Hybla Valley…

  8. Conducting an Introductory Biology Course in an Active Learning Classroom: A Case Study of an Experienced Faculty Member

    ERIC Educational Resources Information Center

    Langley, David; Guzey, S. Selcen

    2014-01-01

    A case study is described that examines the beliefs and practices of a university instructor who teaches regularly in an active learning classroom. His perspective provides insights into the pedagogical practices that drive his success in these learning spaces.

  9. Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity.

    PubMed

    Lerner-Marmarosh, Nicole; Shen, Jenny; Torno, Michael D; Kravets, Anatoliy; Hu, Zhenbo; Maines, Mahin D

    2005-05-17

    We describe here the tyrosine kinase activity of human biliverdin reductase (BVR) and its potential role in the insulin-signaling pathway. BVR is both a substrate for insulin receptor (IR) tyrosine kinase (IRK) activity and a kinase for serine phosphorylation of IR substrate 1 (IRS-1). Our previous studies have revealed serine/threonine kinase activity of BVR. Y198, in the YMKM motif found in the C-terminal domain of BVR, is shown to be a substrate for insulin-activated IRK. This motif in IRS proteins provides a docking site for proteins that contain a Src homology 2 domain. Additionally, Y228 in the YLSF sequence and Y291 are IRK substrates; the former sequence provides optimum recognition motif in the tyrosine phosphatase, SHP-1, and for SHC (Src homology 2 domain containing transfroming protein 1). BVR autophosphorylates N-terminal tyrosines Y72 and Y83. Serine residues in IRS-1 are targets for BVR phosphorylation, and point mutation of serine residues in the kinase domain of the reductase inhibits phosphotransferase activity. Because tyrosine phosphorylation of IRS-1 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, our findings that insulin increases BVR tyrosine phosphorylation and that there is an increase in glucose uptake in response to insulin when expression of BVR is "knocked down" by small interfering RNA suggest a potential role for BVR in the insulin signaling pathway. PMID:15870194

  10. Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.

    PubMed

    Yuan, Dongjuan; Lan, Dongming; Xin, Ruipu; Yang, Bo; Wang, Yonghua

    2014-01-01

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1), Penicillium camembertii lipase U-150 (PCL), and Aspergillus oryzae lipase (AOL). Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity. PMID:24927145

  11. Structures and Activities of Archaeal Members of the LigD 3-Phosphoesterase DNA Repair Enzyme Superfamily

    SciTech Connect

    P Smith; P Nair; U Das; H Zhu; S Shuman

    2011-12-31

    LigD 3'-phosphoesterase (PE) is a component of the bacterial NHEJ apparatus that performs 3'-end-healing reactions at DNA breaks. The tertiary structure, active site and substrate specificity of bacterial PE are unique vis-a-vis other end-healing enzymes. PE homologs are present in archaea, but their properties are uncharted. Here, we demonstrate the end-healing activities of two archaeal PEs - Candidatus Korarchaeum cryptofilum PE (CkoPE; 117 amino acids) and Methanosarcina barkeri PE (MbaPE; 151 amino acids) - and we report their atomic structures at 1.1 and 2.1 {angstrom}, respectively. Archaeal PEs are minimized versions of bacterial PE, consisting of an eight-stranded {beta} barrel and a 3{sub 10} helix. Their active sites are located in a crescent-shaped groove on the barrel's outer surface, wherein two histidines and an aspartate coordinate manganese in an octahedral complex that includes two waters and a phosphate anion. The phosphate is in turn coordinated by arginine and histidine side chains. The conservation of active site architecture in bacterial and archaeal PEs, and the concordant effects of active site mutations, underscore a common catalytic mechanism, entailing transition state stabilization by manganese and the phosphate-binding arginine and histidine. Our results fortify the proposal that PEs comprise a DNA repair superfamily distributed widely among taxa.

  12. A New Member of the TBC1D15 Family from Chiloscyllium plagiosum: Rab GTPase-Activating Protein Based on Rab7 as a Substrate

    PubMed Central

    Li, Yuanyuan; Wang, Weidong; Cheng, Dandan; Wang, Tao; Lu, Conger; Chen, Jian; Nie, Zuoming; Zhang, Wenping; Lv, Zhengbing; Wu, Wutong; Shu, Jianhong

    2015-01-01

    APSL (active peptide from shark liver) is a hepatic stimulator cytokine from the liver of Chiloscyllium. It can effectively protect islet cells and improve complications in mice with alloxan-induced diabetes. Here, we demonstrate that the APSL sequence is present in the N-terminus of novel TBC (Tre-2, Bub2 and Cdc16) domain family, member 15 (TBC1D15) from Chiloscyllium plagiosum. This shark TBC1D15 gene, which contains an ORF of 2088 bp, was identified from a cDNA library of regenerating shark liver. Bioinformatic analysis showed that the gene is highly homologous to TBC1D15 genes from other species. Moreover, the N-terminus of shark TBC1D15 contains a motif of unknown function (DUF3548), which encompasses the APSL fragment. Rab-GAP activity analysis showed that shark TBC1D15 is a new member of the TBC1D15 family. These results demonstrated that shark TBC1D15 possesses Rab-GAP activity using Rab7 as a substrate, which is a common property of the TBC1D15 family. The involvement of APSL at the N-terminus of TBC1D15 also demonstrates that this protein might be involved in insulin signaling and may be associated with the development of type 2 diabetes. The current findings pave the way for further functional and clinical studies of these proteins from marine sources. PMID:25984991

  13. Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.

    PubMed Central

    Nunn, M F; Marsh, J W

    1996-01-01

    Although human immunodeficiency virus (HIV) Nef is essential for the induction of AIDS, its biochemical function has remained an enigma. In this study, HIV Nef protein is shown to associate with a serine-threonine kinase that recognizes histone H4 as a substrate, is serologically related to rat p21-activated kinase (PAK), and is specifically activated by Rac and Cdc42. These characteristics define the Nef-associated kinase as belonging to the PAK family. PAKs initiate kinase cascades in response to environmental stimuli, and their identification as a target of Nef implicates these signaling molecules in HIV pathogenesis and provides a novel target for clinical intervention. PMID:8709241

  14. Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways.

    PubMed

    Guan, Hongtao; Shuaib, Aban; Leon, David Davila De; Angyal, Adrienn; Salazar, Maria; Velasco, Guillermo; Holcombe, Mike; Dower, Steven K; Kiss-Toth, Endre

    2016-01-01

    Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for the various binding partners may influence signalling control is currently unclear. We report that tribbles proteins can bind to an overlapping set of MAPK-kinases (MAPKK) in live cells and dictate the localisation of the complexes. Binding studies in transfected cells reveal common regulatory mechanisms and suggest that tribbles and MAPKs may interact with MAPKKs in a competitive manner. Computational modelling of the impact of tribbles on MAPK activation suggests a high sensitivity of this system to changes in tribbles levels, highlighting that these proteins are ideally placed to control the dynamics and balance of activation of concurrent signalling pathways. PMID:27600771

  15. Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

    PubMed Central

    Guan, Hongtao; Shuaib, Aban; Leon, David Davila De; Angyal, Adrienn; Salazar, Maria; Velasco, Guillermo; Holcombe, Mike; Dower, Steven K.; Kiss-Toth, Endre

    2016-01-01

    Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for the various binding partners may influence signalling control is currently unclear. We report that tribbles proteins can bind to an overlapping set of MAPK-kinases (MAPKK) in live cells and dictate the localisation of the complexes. Binding studies in transfected cells reveal common regulatory mechanisms and suggest that tribbles and MAPKs may interact with MAPKKs in a competitive manner. Computational modelling of the impact of tribbles on MAPK activation suggests a high sensitivity of this system to changes in tribbles levels, highlighting that these proteins are ideally placed to control the dynamics and balance of activation of concurrent signalling pathways. PMID:27600771

  16. Preparation for Separation: Preparing the Military Family for Duty-Related Separation. Crisis Intervention Topics.

    ERIC Educational Resources Information Center

    Hadaway, Nancy L.

    Duty related separation for military family members demands family support programs to help alleviate the stresses produced by separation. Not only is performance of the military member affected, but so is the emotional stability of the spouse and children. Three phases of emotion and behavior can be delineated in the sequence-reaction to the loss…

  17. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.

    PubMed

    Peeters, Miriam C; Mos, Iris; Lenselink, Eelke B; Lucchesi, Martina; IJzerman, Adriaan P; Schwartz, Thue W

    2016-05-01

    The adhesion G protein-coupled receptors [ADGRs/class B2 G protein-coupled receptors (GPCRs)] constitute an ancient family of GPCRs that have recently been demonstrated to play important roles in cellular and developmental processes. Here, we describe a first insight into the structure-function relationship of ADGRs using the family member ADGR subfamily G member 4 (ADGRG4)/GPR112 as a model receptor. In a bioinformatics approach, we compared conserved, functional elements of the well-characterized class A and class B1 secretin-like GPCRs with the ADGRs. We identified several potential equivalent motifs and subjected those to mutational analysis. The importance of the mutated residues was evaluated by examining their effect on the high constitutive activity of the N-terminally truncated ADGRG4/GPR112 in a 1-receptor-1-G protein Saccharomyces cerevisiae screening system and was further confirmed in a transfected mammalian human embryonic kidney 293 cell line. We evaluated the results in light of the crystal structures of the class A adenosine A2A receptor and the class B1 corticotropin-releasing factor receptor 1. ADGRG4 proved to have functionally important motifs resembling class A, class B, and combined elements, but also a unique highly conserved ADGR motif (H3.33). Given the high conservation of these motifs and residues across the adhesion GPCR family, it can be assumed that these are general elements of ADGR function.-Peeters, M. C., Mos, I., Lenselink, E. B., Lucchesi, M., IJzerman, A. P., Schwartz, T. W. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. PMID:26823453

  18. Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents.

    PubMed

    Vergelli, Claudia; Ciciani, Giovanna; Cilibrizzi, Agostino; Crocetti, Letizia; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Guerrini, Gabriella; Iacovone, Antonella; Giovannoni, Maria Paola

    2015-10-01

    A number of heterocycles bearing an arylpiperazinylalkyl side chain and structurally related to the previously described lead ET1 (4-amino-6-methyl-2-[3-(4-p-tolylpiperazin-1-yl)propyl]-5-vinylpyridazin-3(2H)-one) was synthesized and tested for their antinociceptive activity in Writhing Test. Many compounds, tested at doses of 20-40 mg/kg po were able to reduce the number of abdominal constrictions by more than 47% and, in same cases, the potency is comparable to lead ET1 as for 5e, 24a, 27b and 27c. The analgesia induced by the active compounds was completely prevented by pretreatment with α2-antagonist yohimbine, confirming the involvement of the adrenergic system in the mechanism of action for these new compounds. PMID:26361735

  19. The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60.

    PubMed Central

    Defossez, P A; Baert, J L; Monnot, M; de Launoit, Y

    1997-01-01

    Transcription factors are modular entities built up of discrete domains, some devoted to DNA binding and others permitting transcriptional modulation. The structure of DNA binding domains has been thoroughly investigated and structural classes clearly defined. In sharp contrast, the structural constraints put on transactivating regions, if any, are mostly unknown. Our investigations focus on ERM, a eukaryotic transcription factor of the ETS family. We have previously shown that ERM harbours two transactivating domains (TADs) with distinct functional features: AD1 lies in the first 72 amino acids of ERM, while AD2 sits in the last 62. Here we show that AD1 is a bona fide acidic TAD, for it activated transcription in yeast cells, while AD2 did not. AD1 contains a 20 amino acid stretch predicted to form an alpha-helix that is found unchanged in the related PEA3 and ER81 transcription factors. Circular dichroism analysis revealed that a 32 amino acid peptide encompassing this region is unstructured in water but folds into a helix when the hydrophobic solvent trifluoroethanol is added. The isolated helix was sufficient to activate transcription and mutations predicted to disrupt it dramatically affected AD1-driven transactivation, whereas mutations decreasing its acidity had more gentle effects. A phenylalanine residue within the helix was particularly sensitive to mutations. Finally, we observed that ERM bound TAFII60 via AD1 and bound TBP and TAFII40, presumably via other activation domains. PMID:9358152

  20. The Impact of Multiple Concussions on Emotional Distress, Post-Concussive Symptoms, and Neurocognitive Functioning in Active Duty United States Marines Independent of Combat Exposure or Emotional Distress

    PubMed Central

    Lathan, Corinna E.; Bleiberg, Joseph; Tsao, Jack W.

    2014-01-01

    Abstract Controversy exists as to whether the lingering effects of concussion on emotional, physical, and cognitive symptoms is because of the effects of brain trauma or purely to emotional factors such as post-traumatic stress disorder or depression. This study examines the independent effects of concussion on persistent symptoms. The Defense Automated Neurobehavioral Assessment, a clinical decision support tool, was used to assess neurobehavioral functioning in 646 United States Marines, all of whom were fit for duty. Marines were assessed for concussion history, post-concussive symptoms, emotional distress, neurocognitive functioning, and deployment history. Results showed that a recent concussion or ever having experienced a concussion was associated with an increase in emotional distress, but not with persistent post-concussive symptoms (PPCS) or neurocognitive functioning. Having had multiple lifetime concussions, however, was associated with greater emotional distress, PPCS, and reduced neurocognitive functioning that needs attention and rapid discrimination, but not for memory-based tasks. These results are independent of deployment history, combat exposure, and symptoms of post-traumatic stress disorder and depression. Results supported earlier findings that a previous concussion is not generally associated with post-concussive symptoms independent of covariates. In contrast with other studies that failed to find a unique contribution for concussion to PPCS, however, evidence of recent and multiple concussion was seen across a range of emotional distress, post-concussive symptoms, and neurocognitive functioning in this study population. Results are discussed in terms of implications for assessing concussion on return from combat. PMID:25003552

  1. Associations between sleep difficulties and risk factors for cardiovascular disease in veterans and active duty military personnel of the Iraq and Afghanistan conflicts

    PubMed Central

    Bosworth, Hayden B.; Germain, Anne; Lindquist, Jennifer; Olsen, Maren; Brancu, Mira; Beckham, Jean C.

    2015-01-01

    Recent evidence suggests that sleep disturbance may play an important role in the development of cardiovascular disease (CVD). Despite the prevalence of sleep complaints among service members of recent military conflicts, few studies have examined associations between sleep and risk factors for CVD in this population. Symptom checklist items regarding distress about “trouble falling asleep” and “restless/disturbed sleep” were used as proxies for sleep onset and maintenance difficulties to examine these associations in US military service members of recent conflicts. Veterans having both sleep onset and maintenance difficulties had greater odds of being a current smoker and having psychiatric symptoms and diagnoses. Increased odds of a self-reported hypertension diagnosis and elevated systolic blood pressure were also found in certain subsets of this sample. Findings highlight the need for greater recognition of sleep difficulties as a CVD risk factor in a population known to be at increased risk for this condition. PMID:25813984

  2. Survey of Local School Council Members, 1992: A Report on the Findings.

    ERIC Educational Resources Information Center

    Mueller, Siegfried G.

    This report is based on a survey of local school council (LSC) members in Chicago (Illinois) that was conducted in 1992 to determine and share the thoughts of LSC members on planning for school improvements and educational change, implementing policies, training, and fulfilling responsibilities and duties. Nearly 850 council members responded.…

  3. [Patients' rights--doctors' duties].

    PubMed

    Jaeger, L; Bertram, E; Grate, S; Mischkowsky, T; Paul, D; Probst, J; Scala, E; Wbllenweber, H D

    2015-06-01

    On 26 February 2013 the new "Law on Patients' Rights" (hereinafter also the "Law") became effective. This Law strengthens patients' rights vis-à-vis the insurdnce company and also regulates patients' rights regarding their relation to the doctor. This has consequences for the laws on medical liability all doctors must consider. The doctor's performance is and remains a service and such service does not hold any guarantee of success. Nevertheless, this Law primarily reads as a "law on the duties of physicians". To duly take into account these duties and to avoid mistakes and misinterpretation of the Law, the Ethics Committee of the Consortium of Osteosynthesis Trauma Germany (AOTRAUMA-D) has drafted comments on the Law. Brief summaries of its effects are to be found at the end of the respective comment under the heading "Consequences for Practice". The text of the law was influenced particularly by case law, as continuously developed by the German Federal Court of Justice ("BGH"). The implementation of the Law on Patients' Rights was effected by the newly inserted sections 630a to 630h of the German Civil Code (the "BGB"), which are analysed below. The following comments are addressed to physicians only and do not deal with the specific requirements and particularities of the other medical professions such as physiotherapy, midwifery and others so on. Special attention should be paid to the comments on the newly inserted Duty to inform, which has to be fullfilled prior to any diagnostic or therapeutic procedure (sec. 630c para 2 sentence 1 BGB). Under certain conditions the doctor also has to inform the patient about the circumstances that lead to the presumed occurance of a therapeutic or diagnostic malpractice (sec. 630c para. 2 sentence 2 BGB), based on the manifestation of an undesired event or an undesired outcome. As before, the patient's valid consent to any procedure (sec. 630d BGB) is directly linked to the comprehensive and timely provision of information

  4. Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems: VapBC-5 from Mycobacterium tuberculosis

    SciTech Connect

    Miallau, L.; Faller, M.; Chiang, J.; Arbing, M.; Guo, F.; Cascio, D.; Eisenberg, D.

    2009-03-02

    In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapBC family of complexes from M. tuberculosis. The toxin VapC-5 is a compact, 150 residues, two domain {alpha}/{beta} protein. Bent around the toxin is the VapB-5 antitoxin, a 33-residue {alpha}-helix. Assays suggest that the toxin is an Mg-enabled endoribonuclease, inhibited by the antitoxin. The lack of DNase activity is consistent with earlier suggestions that the complex represses its own operon. Furthermore, analysis of the interactions in the binding of the antitoxin to the toxin suggest that exquisite control is required to protect the bacteria cell from toxic VapC-5.

  5. V-band Photometry Of By Draconis-type Variables; Probing Long-term Activity Cycles In Three Pleiades Members

    NASA Astrophysics Data System (ADS)

    Milingo, Jackie; Thomson, A. D.; Truong, P. N.; Marschall, L. A.; Backman, D. E.

    2007-05-01

    Through the collaborative efforts of undergraduates and faculty at Gettysburg and Franklin & Marshall Colleges, we present the compilation of 10 years of differential photometry for three K-type stars in the Pleiades. These young stars have rotational light curves with V-band amplitudes of a few percent (10% in the most active) due to BY Draconis-type behavior (modulation due to rotation of a star with non-uniform surface brightness). With 10 years of photometry reduced, measured, and compiled we are now in a position to probe the V-band variations in these stars for indications of the extent of brightness asymmetry in the photosphere, and characteristics of the long-term activity of these stars. These observations were acquired at the National Undergraduate Research Observatory, operated by Lowell Observatory and Northern Arizona University. This work is supported by Gettysburg College, the Pennsylvania Space Grant Consortium, Arizona Space Grant, NSF grant AST-0354056, and by the Nantucket Maria Mitchell Association.

  6. Reactions of community members regarding community health workers’ activities as a measure of the impact of a training program in Amazonas, Brazil

    PubMed Central

    Kawasaki, Ryoko; Sadamori, Toru; Ferreira de Almeida, Terezinha; Akiyoshi, Megumi; Nishihara, Mika; Yoshimura, Toshiro; Ohnishi, Mayumi

    2014-01-01

    Objectives: The aim of this study was to evaluate the impact of community health worker (CHW) training on recognition and satisfaction regarding the performance of CHWs among members of the community in Amazonas, Brazil, which is a resource-poor area underserved with regard to medical health-care accessibility. Methods: Baseline and endline surveys concerning recognition and satisfaction with respect to CHW performance among members of the community were conducted by interview using a questionnaire before and after implementation of a program to strengthen community health projects in Manicoré, Amazonas, Brazil. One of the components of the project was CHW refresher training, which focused on facilitating adequate use of health-care services and providing primary health care, including health guidance. The baseline survey was performed in February 2004 at the beginning of the project, and the endline survey was performed in February 2006 at the end of the project. There were 82 and 120 CHWs working in Manicoré at the times of the baseline and endline surveys, respectively. Statistical analysis was performed to determine the significance of changes in experience with CHW activities, expected functions of CHWs, and satisfaction regarding the performance of CHWs between the baseline and endline surveys. In addition, qualitative analysis was conducted to evaluate the acceptability, feasibility, and sustainability of CHW refresher training. Results: Overall recognition and level of satisfaction regarding CHW performance among members of the community were improved from the baseline to the endline survey, regardless of type of residential area, such as town and/or remote area. Members of the community came to not expect CHWs to “provide strong medicine” (P < 0.001) and “provide injections” (P < 0.001), and came to appreciate “go to hospital with a sick person” (P = 0.031) as a function and role of CHWs. Conclusions: The results of the present study

  7. Episodic ataxia type 2 manifests as epileptiform electroencephalographic activity with no epileptic attacks in two family members.

    PubMed

    Kaido, Misako; Furuta, Mitsuru; Nakamori, Masayuki; Yuasa, Yoshihito; Takahashi, Masanori P

    2016-04-28

    Here, we report two cases of episodic ataxia type 2 (EA2) in a 63-year-old woman and her 36-year-old daughter. The mother experienced recurrent attacks of cerebellar dysfunction lasting 4 to 5 hours since the age of 41 years. On several occasions, she was admitted to the emergency room, where she was diagnosed with epilepsy or stroke. Based on these diagnoses, she was treated with antiepileptic or anticoagulant drugs, but both treatments were eventually discontinued. The frequency of the attacks increased after the patient reached the age of 62. Interictal neurological examination demonstrated signs of slight cerebellar ataxia, i.e. saccadic eye movements, gaze-directed nystagmus, and mild truncal ataxia. Brain magnetic resonance imaging (MRI) showed cerebellar vermis atrophy. Electroencephalography (EEG) revealed various spike and wave patterns: solitary spikes, spike-and-slow wave complexes, and slow wave bursts. Photoparoxysmal response (PPR) type 3 was also observed. Treatment with acetazolamide abolished the patient's attacks almost completely. The daughter started experiencing 5- to 10-minute ataxic episodes at the age of 16 years. Based on her epileptiform EEG activities with PPR (type 2), antiepileptic drugs (valproate and zonisamide) were prescribed. Despite pharmacological treatment, the attacks recurred; however, their frequency gradually decreased with time, until they almost entirely disappeared when the patient was 33. Unfortunately, migraine-like headaches arose instead. Subtle truncal ataxia was observed during interictal periods. Sanger sequencing of the exons of the CACNA1A gene revealed a novel single base deletion (c.3575delA) in both patients. Despite the difference in age of onset and clinical course, both patients showed clearly epileptiform EEG activities without experiencing the concurrent epileptic episodes. Thus, EA2 is a disease that may be misdiagnosed as epilepsy or stroke in the field of emergency medicine. PMID:27025991

  8. 12 CFR 747.208 - Duties after termination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Duties after termination. 747.208 Section 747... section 206(b) of the Act (12 U.S.C. 1786(b)), insurance of its member accounts to the extent they were... for a period of one year, but no shares issued by the credit union or deposits made after the date...

  9. 12 CFR 747.208 - Duties after termination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Duties after termination. 747.208 Section 747... section 206(b) of the Act (12 U.S.C. 1786(b)), insurance of its member accounts to the extent they were... for a period of one year, but no shares issued by the credit union or deposits made after the date...

  10. Synthesis of seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one and their HIV-RT inhibitory activity.

    PubMed

    Hou, Yuheng; Xing, Shunkai; Shao, Jie; Yin, Zhuqing; Hao, Le; Yang, Tianyu; Zhang, Hongzhi; Zhu, Mo; Chen, Hua; Li, Xiaoliu

    2016-06-24

    Novel seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one were conveniently synthesized by the tandem Staudinger/aza-Wittig/cyclization reaction under microwave radiation. Benzoyl group (Bz) migrations were found in the synthesis of 8c and 9b using D-galactoside or D-mannoside as starting materials, respectively, which was suggested by HMBC and X-ray. The new bi/tricyclic iminosugars 3~4(a-d) and 5(b-d) were examined for their HIV reverse transcriptase (RT) inhibitory activities. The result showed that all compounds except 5b could effectively inhibit RT activity. Among them, compounds 3c and 4c were the best ones with the IC50 values of RT inhibitory activities of 2.11 µM and 2.73 µM, respectively. Structure-activity relationship analysis suggested that the phenyl group in the tricyclic azasugars was beneficial for their anti-HIV RT activity. PMID:27017974

  11. An Analysis of Personal Technology Use by Service Members and Military Behavioral Health Providers.

    PubMed

    Edwards-Stewart, Amanda; Smolenski, Derek J; Reger, Greg M; Bush, Nigel; Workman, Don E

    2016-07-01

    Personal technology use is ubiquitous in the United States today and technology, in general, continues to change the face of health care. However, little is known about the personal technology use of military service members and the behavioral health care providers that treat them. This study reports the technology use of 1,101 active duty service members and 45 behavioral health care providers at a large military installation. Participants reported Internet usage; ownership of smartphones, tablets, and e-readers; usage of mobile applications (apps); and basic demographic information. Compared with providers, service members reported higher rates of smartphone ownership, were more likely to own Android smartphones than iPhones, and spent more time gaming. Both groups spent a comparable amount of time using social media. With the exception of gaming, however, differences between service members and providers were not statistically significant when demographics were matched and controlled. Among service members, younger respondents (18-34) were statistically more likely than older respondents (35-58) to own smartphones, spend time gaming, and engage in social media. Our findings can help inform provider's technology-based education and intervention of their patients and guide the development of new technologies to support the psychological health of service members. PMID:27391625

  12. Partners' attributions for service members' symptoms of combat-related posttraumatic stress disorder.

    PubMed

    Renshaw, Keith D; Allen, Elizabeth S; Carter, Sarah P; Markman, Howard J; Stanley, Scott M

    2014-03-01

    The association of service members' combat-related PTSD with partners' distress is weaker when spouses/partners believe that service members experienced more traumatic events during deployment. Also, when simultaneously examining partners' perceptions of all PTSD symptoms, perceptions of reexperiencing symptoms (the symptoms most obviously connected to traumatic events) are significantly negatively related to distress in partners. These findings are consistent with the notion that partners may be less distressed if they make external, rather than internal, attributions for service members' symptoms. The present study explicitly tests this possibility. Civilian wives of active duty service members completed measures regarding their own marital satisfaction, their perceptions of service members' combat exposure during deployments, their perceptions of service members' symptoms of PTSD, and their attributions for those symptoms. External attributions were significantly positively associated with perceptions of combat exposure (rp=.31) and reexperiencing symptoms (β=.33) and significantly negatively associated with perceptions of numbing/withdrawal symptoms (rp=-.22). In contrast, internal attributions were significantly negatively associated with perceptions of reexperiencing symptoms (β=-.18) and significantly positively associated with perceptions of numbing/withdrawal symptoms (β=.46). Internal attributions significantly moderated the negative association of PTSD symptoms with marital satisfaction, such that the association strengthened as internal attributions increased. These findings are the first explicit support for an attributional understanding of distress in partners of combat veterans. Interventions that alter partners' attributions may improve marital functioning. PMID:24491194

  13. ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2

    PubMed Central

    Wang, De-Shen; Patel, Atish; Sim, Hong-May; Zhang, Yun-Kai; Wang, Yi-Jun; Kathawala, Rishil J.; Zhang, Hui; Talele, Tanaji T.; Ambudkar, Suresh V.; Xu, Rui-Hua; Chen, Zhe-Sheng

    2014-01-01

    Background ARRY-334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases. We conducted this study to determine whether ARRY-334543 can enhance the efficacy of conventional anticancer drugs through interaction with ABC transporters. Methods Lung cancer cell line NCI-H460 and its ABCG2-overexpressing NCI-H460/MX20, as well as the ABCG2-, ABCB1-, and ABCC10-overexpressing transfected cell lines were used for the reversal study. Results Our results demonstrate that ARRY-334543 (1.0 μM) significantly reversed ABCG2-mediated multidrug resistance (MDR) by directly inhibiting the drug efflux function of ABCG2, resulting in the elevated intracellular accumulation of chemotherapeutic drugs in the ABCG2-overexpressing cell lines. In addition, in isolated membranes, ARRY-334543 stimulated ATPase activity and inhibited photolabeling of ABCG2 with [125I]-iodoarylazidoprazosin in a concentration-dependent manner indicating that this drug directly interacts at the drug-binding pocket of this transporter. ARRY-334543 (1.0 μM) only slightly reversed ABCB1- and partially reversed ABCC10-mediated MDR suggesting that it exhibits high affinity towards ABCG2. Moreover, homology modeling predicted the binding conformation of ARRY-334543 at Arg482 centroid-based grid of ABCG2. However, ARRY-334543 at reversal concentration did not affect the expression level of ABCG2, AKT and ERK1/2 and regulate the re-localization of ABCG2. Conclusion We conclude that ARRY-334543 significantly reverses drug resistance mediated by ABCG2. PMID:24939447

  14. Durations of service until first and recurrent episodes of clinically significant back pain, active component military members: changes among new accessions to service since calendar year 2000.

    PubMed

    Brundage, John F; Hu, Zheng; Clark, Leslie L

    2016-01-01

    This report summarizes frequencies and timing of first and recurrent episodes of back pain treated in the U.S. Military Health System among more than 2 million military members who began active service between July 2000 and June 2012. In the population overall, at least 5% were affected by clinically significant back pain within 6 months and 10% within 13 months of beginning active service; and 34% had at least one episode of back pain while in active service during the surveillance period. After initial episodes of back pain, more than half (54%) of those affected had at least one recurrent episode; and after first recurrences, 65% had second recurrences while still in active service. In general, back pain episode-free periods preceding initial and between successive episodes markedly decreased during the period. Frequencies and timing of back pain episodes varied in relation to service branch, gender, and occupation. Acute back pain is a common disorder that is unpredictable in onset and often debilitating. Its prevention should be a military medical research objective of high priority. PMID:26836203

  15. Tfs1p, a Member of the PEBP Family, Inhibits the Ira2p but Not the Ira1p Ras GTPase-Activating Protein in Saccharomyces cerevisiae

    PubMed Central

    Chautard, Hélène; Jacquet, Michel; Schoentgen, Françoise; Bureaud, Nicole; Bénédetti, Hélène

    2004-01-01

    Ras proteins are guanine nucleotide-binding proteins that are highly conserved among eukaryotes. They are involved in signal transduction pathways and are tightly regulated by two sets of antagonistic proteins: GTPase-activating proteins (GAPs) inhibit Ras proteins, whereas guanine exchange factors activate them. In this work, we describe Tfs1p, the first physiological inhibitor of a Ras GAP, Ira2p, in Saccharomyces cerevisiae. TFS1 is a multicopy suppressor of the cdc25-1 mutation in yeast and corresponds to the so-called Ic CPY cytoplasmic inhibitor. Moreover, Tfs1p belongs to the phosphatidylethanolamine-binding protein (PEBP) family, one member of which is RKIP, a kinase and serine protease inhibitor and a metastasis inhibitor in prostate cancer. In this work, the results of (i) a two-hybrid screen of a yeast genomic library, (ii) glutathione S-transferase pulldown experiments, (iii) multicopy suppressor tests of cdc25-1 mutants, and (iv) stress resistance tests to evaluate the activation level of Ras demonstrate that Tfs1p interacts with and inhibits Ira2p. We further show that the conserved ligand-binding pocket of Tfs1—the hallmark of the PEBP family—is important for its inhibitory activity. PMID:15075275

  16. Differences in Muscle and Adipose Tissue Gene Expression and Cardio-Metabolic Risk Factors in the Members of Physical Activity Discordant Twin Pairs

    PubMed Central

    Leskinen, Tuija; Rinnankoski-Tuikka, Rita; Rintala, Mirva; Seppänen-Laakso, Tuulikki; Pöllänen, Eija; Alen, Markku; Sipilä, Sarianna; Kaprio, Jaakko; Kovanen, Vuokko; Rahkila, Paavo; Orešič, Matej; Kainulainen, Heikki; Kujala, Urho M.

    2010-01-01

    High physical activity/aerobic fitness predicts low morbidity and mortality. Our aim was to identify the most up-regulated gene sets related to long-term physical activity vs. inactivity in skeletal muscle and adipose tissues and to obtain further information about their link with cardio-metabolic risk factors. We studied ten same-sex twin pairs (age range 50–74 years) who had been discordant for leisure-time physical activity for 30 years. The examinations included biopsies from m. vastus lateralis and abdominal subcutaneous adipose tissue. RNA was analyzed with the genome-wide Illumina Human WG-6 v3.0 Expression BeadChip. For pathway analysis we used Gene Set Enrichment Analysis utilizing active vs. inactive co-twin gene expression ratios. Our findings showed that among the physically active members of twin pairs, as compared to their inactive co-twins, gene expression in the muscle tissue samples was chronically up-regulated for the central pathways related to energy metabolism, including oxidative phosphorylation, lipid metabolism and supportive metabolic pathways. Up-regulation of these pathways was associated in particular with aerobic fitness and high HDL cholesterol levels. In fat tissue we found physical activity-associated increases in the expression of polyunsaturated fatty acid metabolism and branched-chain amino acid degradation gene sets both of which associated with decreased ‘high-risk’ ectopic body fat and plasma glucose levels. Consistent with other findings, plasma lipidomics analysis showed up-regulation of the triacylglycerols containing the polyunsaturated fatty acids. Our findings identified skeletal muscle and fat tissue pathways which are associated with the long-term physical activity and reduced cardio-metabolic disease risk, including increased aerobic fitness. In particular, improved skeletal muscle oxidative energy and lipid metabolism as well as changes in adipocyte function and redistribution of body fat are associated with

  17. Personality characteristics of Wikipedia members.

    PubMed

    Amichai-Hamburger, Yair; Lamdan, Naama; Madiel, Rinat; Hayat, Tsahi

    2008-12-01

    Wikipedia is an online, free access, volunteer-contributed encyclopedia. This article focuses on the Wikipedians' (Wikipedia users) personality characteristics, studying Wikipedians' conceptions of Real-Me and BFI dimensions. To survey these aspects, we posted links to two online web questionnaires; one was targeted at Wikipedians and the second to non-Wikipedia users. One hundred and thirty-nine subjects participated in the study, of which 69 were active Wikipedia members. It was found that Wikipedia members locate their real me on the Internet more frequently as compared to non-Wikipedia members. Variance analysis revealed significant differences between Wikipedia members and non-Wikipedia members in agreeableness, openness, and conscientiousness, which were lower for the Wikipedia members. An interaction was found between Wikipedia membership and gender: introverted women were more likely to be Wikipedia members as compared with extroverted women. The results of this study are discussed with special emphasis on the understanding of the motivators of Wikipedia members. PMID:18954273

  18. A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages

    PubMed Central

    Won, Kyung-Jong; Park, Sung-Won; Lee, Seunghoon; Kong, Il-Keun; Chae, Jung-Il; Kim, Bokyung; Lee, Eun-Jong

    2015-01-01

    The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages. PMID:26557807

  19. A Multisite Study of the Relationships between Blast Exposures and Symptom Reporting in a Post-Deployment Active Duty Military Population with Mild Traumatic Brain Injury

    PubMed Central

    Miller, Kelly J.; Lange, Rael T.; Cooper, Douglas B.; Tate, David F.; Bailie, Jason; Brickell, Tracey A.; French, Louis M.; Asmussen, Sarah; Kennedy, Jan E.

    2014-01-01

    Abstract Explosive devices have been the most frequent cause of traumatic brain injury (TBI) among deployed contemporary U.S. service members. The purpose of this study was to examine the influence of previous cumulative blast exposures (that did or did not result in TBI) on later post-concussion and post-traumatic symptom reporting after sustaining a mild TBI (MTBI). Participants were 573 service members who sustained MTBI divided into four groups by number of blast exposures (1, 2, 3, and 4–10) and a nonblast control group. Post-concussion symptoms were measured using the Neurobehavioral Symptom Inventory (NSI) and post-traumatic stress disorder (PTSD) symptoms using the Post-traumatic Checklist-Civilian version (PCL-C). Results show groups significantly differed on total NSI scores (p<0.001), where symptom endorsement increased as number of reported blast exposures increased. Total NSI scores were significantly higher for the 3– and 4–10 blast groups compared with the 1- and 2-blast groups with effect sizes ranging from small to moderate (d=0.31 to 0.63). After controlling for PTSD symptoms using the PCL-C total score, NSI total score differences remained between the 4–10-blast group and the 1- and 2-blast groups, but were less pronounced (d=0.35 and d=0.24, respectively). Analyses of NSI subscale scores using PCL-C scores as a covariate revealed significant between-blast group differences on cognitive, sensory, and somatic, but not affective symptoms. Regression analyses revealed that cumulative blast exposures accounted for a small but significant amount of the variance in total NSI scores (4.8%; p=0.009) and total PCL-C scores (2.3%; p<0.001). Among service members exposed to blast, post-concussion symptom reporting increased as a function of cumulative blast exposures. Future research will need to determine the relationship between cumulative blast exposures, symptom reporting, and neuropathological changes. PMID:25036531

  20. Ethnic differences in caregiving duties and burdens among parents and siblings of persons with severe mental illnesses.

    PubMed

    Horwitz, A V; Reinhard, S C

    1995-06-01

    The policy of community care for the seriously mentally ill increases the caregiving duties and resulting burden on families with members who have a mental illness. Ethnicity is one factor that might have an important impact on the caregiving duties family members perform and the burden that results from these duties. This study uses interviews with 78 parents and 70 siblings of patients scheduled for imminent release from a state mental hospital. The findings indicate that Black and White parents have equivalent caregiving duties, but White parents report substantially more caregiver burden. Black siblings report more caregiving duties than White siblings but report less caregiver burden. These ethnic differences remain after controls for income, gender, age, diagnosis, perceived stigma, and coresidence. The results indicate that ethnicity can be a critical factor affecting levels of informal caretaking for persons with serious mental illnesses. PMID:9113139

  1. RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

    PubMed Central

    Ganju, Ramesh K.; Hatch, William C.; Avraham, Hava; Ona, Mel A.; Druker, Brian; Avraham, Shalom; Groopman, Jerome E.

    1997-01-01

    The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has previously been reported to participate in signal transduction in neuronal cells, megakaryocytes, and B lymphocytes. We have found that RAFTK is constitutively expressed in human T cells and is rapidly phosphorylated upon the activation of the T cell receptor (TCR). This activation also results in an increase in the autophosphorylation and kinase activity of RAFTK. After its stimulation, there was an increase in the association of the src cytoplasmic tyrosine kinase Fyn and the adapter protein Grb2. This association was mediated through the SH2 domains of Fyn and Grb2. RAFTK also co-immunoprecipitates with the SH2 domain of Lck and with the cytoskeletal protein paxillin through its COOH-terminal proline-rich domain. The tyrosine phosphorylation of RAFTK after T cell receptor-mediated stimulation was reduced by the pretreatment of cells with cytochalasin D, suggesting the role of the cytoskeleton in this process. These observations indicate that RAFTK participates in T cell receptor signaling and may act to link signals from the cell surface to the cytoskeleton and thereby affect the host immune response. PMID:9091579

  2. Light Duty Efficient, Clean Combustion

    SciTech Connect

    Stanton, Donald W.

    2011-06-03

    Cummins has successfully completed the Light Duty Efficient Clean Combustion (LDECC) cooperative program with DoE. This program was established in 2007 in support of the Department of Energy’s Vehicles Technologies Advanced Combustion and Emissions Control initiative to remove critical barriers to the commercialization of advanced, high efficiency, emissions compliant internal combustion (IC) engines for light duty vehicles. Work in this area expanded the fundamental knowledge of engine combustion to new regimes and advanced the knowledge of fuel requirements for these diesel engines to realize their full potential. All of our objectives were met with fuel efficiency improvement targets exceeded.

  3. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could ...

  4. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evidence supports the theory that the bacterial communities colonizing E. purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be a...

  5. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection...

  6. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection...

  7. 40 CFR 86.1811-09 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-09 Section 86.1811-09 Protection...

  8. 40 CFR 86.1811-09 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-09 Section 86.1811-09 Protection...

  9. 40 CFR 86.1811-09 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-09 Section 86.1811-09 Protection...

  10. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection...

  11. 40 CFR 86.1811-09 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-09 Section 86.1811-09 Protection...

  12. 40 CFR 86.1811-10 - Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Emission standards for light-duty vehicles, light-duty trucks and medium-duty passenger vehicles. 86.1811-10 Section 86.1811-10 Protection...

  13. Strained Si-O-Si bonds in amorphous SiO2 materials: A family member of active centers in radio, photo, and chemical responses

    NASA Astrophysics Data System (ADS)

    Awazu, Koichi; Kawazoe, Hiroshi

    2003-11-01

    Amorphous SiO2 (a-SiO2), such as bulk silica glasses and thin films has been one of the key materials in modern optoelectronic industries. These materials are currently used in communication technologies as optical fibers, thin films for electrical insulation in dynamic random access memories (DRAM), and optical lenses for excimer laser lithography, for example. The property essential for these applications is the wide band gap amounting to ˜9 eV. However, bulk silica glasses commercially available and silica thin films show photoresponses to subband gap lights in the vicinity of 5 eV and unexpected trapping of charges, and the behavior has a strong dependency on the preparation history. A number of studies were carried out to clarify the relationship between the properties and structural imperfections in the materials and the formation mechanisms of the defects. There are two categories of the imperfections: one is dopant- or impurity-related imperfections and the other is nonstoichiometry related defects. These defects constitute gap states in a-SiO2. The structural identification was usually performed by absorption and emission spectroscopy in the visible-ultraviolet (UV) region and electron spin resonance (ESR). The experimentally proposed models were compared with the predictions by theoretical calculations of energy levels. Recent development of the excimer laser lithography technique led us to recognize that a latent member, which has been unnoticed because of no response to the optical absorption or emission in the visible-UV range and ESR absorption, exists in the family of active centers in a-SiO2, that is a strained Si-O-Si bond originating from the planar three membered ring. In contrast, the puckered four membered ring is unstrained. Although it has been pointed out that there was a wide distribution in Si-O-Si bond angle from 90° to 180° by x-ray analysis or 29Si solid state nuclear magnetic resonance, the physical, and chemical responses of the Si

  14. Synthesis, characterization and in vitro anticancer activity of 18-membered octaazamacrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II)

    NASA Astrophysics Data System (ADS)

    Kareem, Abdul; Zafar, Hina; Sherwani, Asif; Mohammad, Owais; Khan, Tahir Ali

    2014-10-01

    An effective series of 18 membered octaazamacrocyclic complexes of the type [MLX2], where X = Cl or NO3 have been synthesized by template condensation reaction of oxalyl dihydrazide with dibenzoylmethane and metal salt in 2:2:1 molar ratio. The formation of macrocyclic framework, stereochemistry and their overall geometry have been characterized by various physico-chemical studies viz., elemental analysis, electron spray ionization-mass spectrometry (ESI-MS), I.R, UV-Vis, 1H NMR, 13C NMR spectroscopy, X-ray diffraction (XRD) and TGA/DTA studies. These studies suggest formation of octahedral macrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II). The molar conductance values suggest nonelectrolytic nature for all the complexes. Thermogravimatric analysis shows that all the complexes are stable up to 600 °C. All these complexes have been tested against different human cancer cell lines i.e. human hepatocellular carcinoma (Hep3B), human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF7) and normal cells (PBMC). The newly synthesized 18-membered octaazamacrocyclic complexes during in vitro anticancer evaluation, displayed moderate to good cytotoxicity on liver (Hep3B), cervical (HeLa) and breast (MCF7) cancer cell lines, respectively. The most effective anticancer cadmium complex (C34H28N10CdO10) was found to be active with IC50 values, 2.44 ± 1.500, 3.55 ± 1.600 and 4.82 ± 1.400 in micro-molar on liver, cervical and breast cancer cell lines, respectively.

  15. Drafting Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This task list is intended for use in planning and/or evaluating a competency-based course in drafting. The tasks required to perform the duties of seven types of drafters (i.e., general, architectural, electronic, civil, structural, mechanical, and process pipe drafters) and technical illustrators are outlined. The following are among the duties…

  16. Electricity Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This task list is intended for use in planning and/or evaluating a competency-based course in electricity. The guide outlines the tasks entailed in 10 different duties typically required of employees in the following occupations: residential electrician apprentice, material handler/supply clerk, maintenance electrician apprentice,…

  17. Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML

    PubMed Central

    2012-01-01

    Background WASP family proteins stimulate the actin-nucleating activity of the ARP2/3 complex. They include members of the well-known WASP and WAVE/Scar proteins, and the recently identified WASH and WHAMM proteins. WASP family proteins contain family specific N-terminal domains followed by proline-rich regions and C-terminal VCA domains that harbour the ARP2/3-activating regions. Results To reveal the evolution of ARP2/3 activation by WASP family proteins we performed a "holistic" analysis by manually assembling and annotating all homologs in most of the eukaryotic genomes available. We have identified two new families: the WAML proteins (WASP and MIM like), which combine the membrane-deforming and actin bundling functions of the IMD domains with the ARP2/3-activating VCA regions, and the WAWH protein (WASP without WH1 domain) that have been identified in amoebae, Apusozoa, and the anole lizard. Surprisingly, with one exception we did not identify any alternative splice forms for WASP family proteins, which is in strong contrast to other actin-binding proteins like Ena/VASP, MIM, or NHS proteins that share domains with WASP proteins. Conclusions Our analysis showed that the last common ancestor of the eukaryotes must have contained a homolog of WASP, WAVE, and WASH. Specific families have subsequently been lost in many taxa like the WASPs in plants, algae, Stramenopiles, and Euglenozoa, and the WASH proteins in fungi. The WHAMM proteins are metazoa specific and have most probably been invented by the Eumetazoa. The diversity of WASP family proteins has strongly been increased by many species- and taxon-specific gene duplications and multimerisations. All data is freely accessible via http://www.cymobase.org. PMID:22316129

  18. Glial Cell Line-Derived Neurotrophic Factor Family Members Reduce Microglial Activation via Inhibiting p38MAPKs-Mediated Inflammatory Responses

    PubMed Central

    Rickert, Uta; Grampp, Steffen; Wilms, Henrik; Spreu, Jessica; Knerlich-Lukoschus, Friederike; Held-Feindt, Janka; Lucius, Ralph

    2014-01-01

    Previous studies have shown that glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) are potent survival factors for dopaminergic neurons and motoneurons with therapeutic potential for Parkinson's disease. However, little is known about direct influences of the GFL on microglia function, which are known to express part of the GDNF receptor system. Using RT-PCR and immunohistochemistrym we investigated the expression of the GDNF family receptor alpha 1 (GFR alpha) and the coreceptor transmembrane receptor tyrosine kinase (RET) in rat microglia in vitro as well as the effect of GFL on the expression of proinflammatory molecules in LPS activated microglia. We could show that GFL are able to regulate microglia functions and suggest that part of the well known neuroprotective action may be related to the suppression of microglial activation. We further elucidated the functional significance and pathophysiological implications of these findings and demonstrate that microglia are target cells of members of the GFL (GDNF and the structurally related neurotrophic factors neurturin (NRTN), artemin (ARTN), and persephin (PSPN)). PMID:26317008

  19. Time utilization, productivity and costs of solo and extended duty auxiliary dental practice.

    PubMed

    Tan, H H; van Gemert, H G

    1977-07-01

    A study was conducted to compare the time utilization of the dentist, and productivity and costs for solo (one dentist, one chairside assistant and one treatment room) and extended duty settings (one dentist, two extended duty dental hygienists, one chairside assistant and two treatment rooms). Only amalgam and composite restorations done in a general group practice were included. In the extended duty setting the dentist spent more time in managerial activities and less time in treatment than in the solo setting. Nevertheless, the dentist in the extended duty setting produced 53% more restorations as compared with solo practice. The cost ratio of solo to extended duty practice was computed to 1:1.52. From the point of view of microeconomics, the extended duty setting was found no worse than the solo setting. PMID:268260

  20. 7 CFR 959.35 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Handling Committee § 959.35 Duties. It shall be, among other things, the duty of the committee: (a) As soon..., and to protect the handling of committee funds through fidelity bonds for employees; (e)...

  1. 7 CFR 930.31 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrative Body § 930.31 Duties. The Board shall have, among others, the following duties: (a) To select such... investigate compliance with the provisions of this part; (n) To develop and submit an annual marketing...

  2. 7 CFR 930.31 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Administrative Body § 930.31 Duties. The Board shall have, among others, the following duties: (a) To select such... investigate compliance with the provisions of this part; (n) To develop and submit an annual marketing...

  3. 7 CFR 930.31 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrative Body § 930.31 Duties. The Board shall have, among others, the following duties: (a) To select such... investigate compliance with the provisions of this part; (n) To develop and submit an annual marketing...

  4. 7 CFR 930.31 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Body § 930.31 Duties. The Board shall have, among others, the following duties: (a) To select such... investigate compliance with the provisions of this part; (n) To develop and submit an annual marketing...

  5. 7 CFR 930.31 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Body § 930.31 Duties. The Board shall have, among others, the following duties: (a) To select such... investigate compliance with the provisions of this part; (n) To develop and submit an annual marketing...

  6. Defining the physician's duty to warn: consensus statement of Ontario's Medical Expert Panel on Duty to Inform

    PubMed Central

    Ferris, L E; Barkun, H; Carlisle, J; Hoffman, B; Katz, C; Silverman, M

    1998-01-01

    Ontario's Medical Expert Panel on Duty to Inform was formed to consider the duty of Ontario physicians in circumstances where a patient threatens to kill or cause serious bodily harm to a third party. The panel was concerned about the implications of any duty to inform on the integrity of the physician-patient relationship, particularly with respect to confidentiality. The panel agreed that regulations safeguarding the confidentiality of patient information ought to be changed only if there is a critical reason for doing so, but, after deliberation, the panel members concluded that the need to protect the public from serious risk of harm is a paramount concern that should supersede the duty of confidentiality. The recommendations reported here were endorsed in principle by the panelists and the groups they represented (the Royal College of Physicians and Surgeons of Canada, the Canadian Medical Protective Association, the College of Physicians and Surgeons of Ontario, the Ontario College of Family Physicians and the Ontario Medical Association) and are being implemented by the College of Physicians and Surgeons of Ontario. PMID:9629112

  7. 40 CFR 94.105 - Duty cycles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Duty cycles. 94.105 Section 94.105... EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES Test Procedures § 94.105 Duty cycles. (a) Overview. For....8(e), engines shall be tested using the appropriate duty cycles described in this section....

  8. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  9. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  10. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  11. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  12. 19 CFR 151.65 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.65 Duties. Duties on wool or hair... determination of clean yield. Estimated and liquidated duties on wool or hair tested for clean yield pursuant to... appropriate adjustment of the estimated percentage clean yield shown on the entry summary for the wool or...

  13. Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspase-8 activity in H2O2-induced human HUC-F2 fibroblasts

    PubMed Central

    Shimizu, Yuri; Miyakura, Reiko; Otsuka, Yuzuru

    2015-01-01

    Objective: Apoptosis is characterized by distinct morphological and biochemical changes that occur upon activation of a family of serine proteases known as caspases. Reactive oxygen species (ROS) induce apoptosis in many cell systems. Nuclear receptor subfamily 4, group A, member 1 (NR4A1) has been shown to induce apoptosis in a number of cell lineages, but can also paradoxically act as a death inhibitory factor. In the current study, we focused on the potential role of NR4A1 in hydrogen peroxide (H2O2)-induced apoptosis of normal human umbilical cord fibroblast (HUC-F2) cells. Methods: Growth of HUC-F2 cells treated with H2O2 was measured by MTT assay. Analysis of gene expression was performed with a STEP ONE PLUS Real Time PCR system. Inactivation of NR4A1 was treated with siRNA. Apoptosis was measured by Beckman Coulter flow cytometer after inhibition of NR4A1 with siRNA and H2O2 treatment. Caspase -3, -8 and -9 was measured by caspase assay kit. Results: H2O2 treatment led to enhanced NR4A1 expression. Moreover inhibition of NR4A1 with specific siRNA in HUC-F2 cells triggered an increase in apoptosis and caspase-8 and -3 activities following the addition of H2O2. Discussion: Our results collectively suggest that NR4A1 is a regulator that inhibits extrinsic apoptosis in HUC-F2 cells during oxidative stress through reduction of caspase-8 and -3 activities. PMID:25330024

  14. Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

    PubMed

    Matthews, Hayden; Ranson, Marie; Kelso, Michael J

    2011-11-01

    Amiloride.HCl is clinically used as an oral potassium-sparing diuretic, but multiple studies in biochemical, cellular and animal models have shown that the drug also possesses anti-tumour and anti-metastasis activities. The additional effects appear to arise through inhibition of two discrete targets: (i) the sodium-hydrogen exchanger 1 (NHE1), a membrane protein responsible for the characteristically low extracellular pH of tumours and (ii) the urokinase-type plasminogen activator (uPA), a serine protease mediator of cell migration, invasion and metastasis and well-known marker of poor prognosis in cancer. This mini-review summarises for the first time the reported anti-tumour/metastasis effects of amiloride in experimental models, discusses the putative molecular mechanisms responsible for these effects and concludes by commenting on the pros and cons of trialling amiloride or one of its structural analogues as potential new anti-tumour/metastasis drugs. PMID:21544803

  15. 48 CFR 245.603-70 - Contractor performance of plant clearance duties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... plant clearance duties. 245.603-70 Section 245.603-70 Federal Acquisition Regulations System DEFENSE..., Redistribution, and Disposal of Contractor Inventory 245.603-70 Contractor performance of plant clearance duties... activity approval and contractor concurrence, authorize selected contractors to perform certain...

  16. Cardiovascular Complaints Among Military Members During Operation Enduring Freedom.

    PubMed

    Watts, James A; Russo, Frank D; Villines, Todd C; Jones, Samuel O; Patino, Gilberto; Nasir, Javed M; Eckart, Robert E; Steel, Kevin E

    2016-01-01

    During Operation Enduring Freedom, the US military began deploying a dedicated theater cardiology consultant to Afghanistan in an effort to increase rates of return to duty in service members with cardiovascular complaints. This study was designed to categorize these complaints and determine the effect on both aeromedical evacuation and return to duty rates during a 2.5 year observation period. A total of 1,495 service members were evaluated, with 43% presenting due to chest pain followed by arrhythmias/palpitations (24.5%) and syncope (13.5%). Eighty-five percent of individuals returned to duty, most commonly with complaints of noncardiac chest pain, palpitations, or abnormal electrocardiograms. Fifteen percent were evacuated out of theater, most often with acute coronary syndrome, pulmonary embolus, or ventricular tachycardia. The forward-deployed theater cardiology consultant is vital in the disposition of military members by effectively parsing out life threatening cardiovascular conditions versus low risk diagnoses that can safely return to duty. PMID:27215883

  17. Duties to kin through a tragi-comic lens.

    PubMed

    Gillett, Grant; Hankey, Robin

    2014-06-01

    Euripides' Alcestis (1959) raises the issue of ethical duties within families and exposes the romantic postures and rhetoric that can dominate such discussions. Should anybody be asked to sacrifice themselves or even undergo significant health risks for members of their own family? (An issue that is also relevant in considering our duties to future generations in terms of the earth we leave to them.) The issue that is dramatized to a heroic level in Alcestis arises in live organ and tissue donation within a family and challenges the idea that families should be trusted to sort out solutions that they can all live with. Alcestis intensifies the debate because the sacrifice of one life for another is its topic but, in doing so, it exposes many traps lying in wait for ethicists and medical jurists who boldly enter such debates (where emotions create shifting ground on which angels fear to tread). PMID:24771522

  18. An Enzymatically Active β-1,3-Glucanase from Ash Pollen with Allergenic Properties: A Particular Member in the Oleaceae Family

    PubMed Central

    Torres, María; Palomares, Oscar; Quiralte, Joaquín; Pauli, Gabrielle; Rodríguez, Rosalía; Villalba, Mayte

    2015-01-01

    Endo-β-1,3-glucanases are widespread enzymes with glycosyl hydrolitic activity involved in carbohydrate remodelling during the germination and pollen tube growth. Although members of this protein family with allergenic activity have been reported, their effective contribution to allergy is little known. In this work, we identified Fra e 9 as a novel allergenic β-1,3-glucanase from ash pollen. We produced the catalytic and carbohydrate-binding domains as two independent recombinant proteins and characterized them from structural, biochemical and immunological point of view in comparison to their counterparts from olive pollen. We showed that despite having significant differences in biochemical activity Fra e 9 and Ole e 9 display similar IgE-binding capacity, suggesting that β-1,3-glucanases represent an heterogeneous family that could display intrinsic allergenic capacity. Specific cDNA encoding Fra e 9 was cloned and sequenced. The full-length cDNA encoded a polypeptide chain of 461 amino acids containing a signal peptide of 29 residues, leading to a mature protein of 47760.2 Da and a pI of 8.66. An N-terminal catalytic domain and a C-terminal carbohydrate-binding module are the components of this enzyme. Despite the phylogenetic proximity to the olive pollen β-1,3-glucanase, Ole e 9, there is only a 39% identity between both sequences. The N- and C-terminal domains have been produced as independent recombinant proteins in Escherichia coli and Pichia pastoris, respectively. Although a low or null enzymatic activity has been associated to long β-1,3-glucanases, the recombinant N-terminal domain has 200-fold higher hydrolytic activity on laminarin than reported for Ole e 9. The C-terminal domain of Fra e 9, a cysteine-rich compact structure, is able to bind laminarin. Both molecules retain comparable IgE-binding capacity when assayed with allergic sera. In summary, the structural and functional comparison between these two closely phylogenetic related enzymes

  19. The Porcine Chloride Channel Calcium-Activated Family Member pCLCA4a Mirrors Lung Expression of the Human hCLCA4

    PubMed Central

    Plog, Stephanie; Grötzsch, Tanja; Klymiuk, Nikolai; Kobalz, Ursula; Gruber, Achim D.

    2012-01-01

    Pig models of cystic fibrosis (CF) have recently been established that are expected to mimic the human disease closer than mouse models do. The human CLCA (originally named chloride channels, calcium-activated) member hCLCA4 is considered a potential modifier of disease severity in CF, but its murine ortholog, mCLCA6, is not expressed in the mouse lung. Here, we have characterized the genomic structure, protein processing, and tissue expression patterns of the porcine ortholog to hCLCA4, pCLCA4a. The genomic structure and cellular protein processing of pCLCA4a were found to closely mirror those of hCLCA4 and mCLCA6. Similar to human lung, pCLCA4a mRNA was strongly expressed in porcine lungs, and the pCLCA4a protein was immunohistochemically detected on the apical membranes of tracheal and bronchial epithelial cells. This stands in sharp contrast to mouse mCLCA6, which has been detected exclusively in intestinal epithelia but not the murine lung. The results may add to the understanding of species-specific differences in the CF phenotype and support the notion that the CF pig model may be more suitable than murine models to study the role of hCLCA4. PMID:22205680

  20. Mutational Analysis of AREA, a Transcriptional Activator Mediating Nitrogen Metabolite Repression in Aspergillus nidulans and a Member of the “Streetwise” GATA Family of Transcription Factors

    PubMed Central

    Wilson, Richard A.; Arst, Herbert N.

    1998-01-01

    Summary: The transcriptional activator AREA is a member of the GATA family of transcription factors and mediates nitrogen metabolite repression in the fungus Aspergillus nidulans. The nutritional versatility of A. nidulans and its amenability to classical and reverse genetic manipulations make the AREA DNA binding domain (DBD) a useful model for analyzing GATA family DBDs, particularly as structures of two AREA-DNA complexes have been determined. The 109 extant mutant forms of the AREA DBD surveyed here constitute one of the highest totals of eukaryotic transcription factor DBD mutants, are discussed in light of the roles of individual residues, and are compared to corresponding mutant sequence changes in other fungal GATA factor DBDs. Other topics include delineation of the DBD using both homology and mutational truncation, use of frameshift reversion to detect regions of tolerance to mutational change, the finding that duplication of the DBD can apparently enhance AREA function, and use of the AREA system to analyze a vertebrate GATA factor DBD. Some major points to emerge from work on the AREA DBD are (i) tolerance to sequence change (with retention of function) is surprisingly great, (ii) mutational changes in a transcription factor can have widely differing, even opposing, effects on expression of different structural genes so that monitoring expression of one or even several structural genes can be insufficient and possibly misleading, and (iii) a mutational change altering local hydrophobic packing and DNA binding target specificity can markedly influence the behavior of mutational changes elsewhere in the DBD. PMID:9729601

  1. Hyperosmotic stress activates the expression of members of the miR-15/107 family and induces downregulation of anti-apoptotic genes in rat liver

    PubMed Central

    Santosa, David; Castoldi, Mirco; Paluschinski, Martha; Sommerfeld, Annika; Häussinger, Dieter

    2015-01-01

    microRNAs are an abundant class of small non-coding RNAs that negatively regulate gene expression. Importantly, microRNA activity has been linked to the control of cellular stress response. In the present study, we investigated whether the expression of hepatic microRNAs is affected by changes in ambient osmolarity. It is shown that hyperosmotic exposure of perfused rat liver induces a rapid upregulation of miR-15a, miR-15b and miR-16, which are members of the miR-15/107 microRNAs superfamily. It was also identified that hyperosmolarity significantly reduces the expression of anti-apoptotic genes including Bcl2, Ccnd1, Mcl1, Faim, Aatf, Bfar and Ikbkb, which are either validated or predicted targets of these microRNAs. Moreover, through the application of NOX and JNK inhibitors as well as benzylamine it is shown that the observed response is mediated by reactive oxygen species (ROS), suggesting that miR-15a, miR-15b and miR-16 are novel redoximiRs. It is concluded that the response of these three microRNAs to osmotic stress is ROS-mediated and that it might contribute to the development of a proapoptotic phenotype. PMID:26195352

  2. 19 CFR 159.21 - Quantity upon which duties based.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Quantity upon which duties based. 159.21 Section 159.21 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) LIQUIDATION OF DUTIES Weight, Gage, and Measure § 159.21 Quantity upon which duties based. Insofar as duties are...

  3. Analysis of the Role of the Active Site Residue Arg98 in the Flavoprotein Tryptophan 2-Monooxygenase, a Member of the l-Amino Oxidase Family†

    PubMed Central

    Sobrado, Pablo; Fitzpatrick, Paul F.

    2006-01-01

    The flavoprotein tryptophan 2-monooxygenase catalyzes the oxidative decarboxylation of tryptophan to indoleacetamide. We have previously identified tryptophan 2-monooxygenase as a homologue of l-amino acid oxidase [Sobrado, P., and Fitzpatrick, P. F. (2002) Arch. Biochem. Biophys. 402, 24–30]. On the basis of the sequence comparisons of the different LAAO family members, Arg98 of tryptophan 2-monooxygenase can be identified as an active site residue which interacts with the carboxylate of the amino acid substrate. The catalytic properties of R98K and R98A tryptophan 2-monooxygenase have been characterized to evaluate the role of this residue. Mutation of Arg98 to lysine decreases the first-order rate constant for flavin reduction by 180-fold and the second-order rate constant for flavin oxidation by 26-fold, has no significant effect on the Kd value for tryptophan or the Ki value for the competitive inhibitor indoleacetamide, and increases the Ki value for indolepyruvate less than 2-fold. Mutation of this residue to alanine decreases the rate constants for reduction and oxidation an additional 5- and 2-fold, respectively, and increases the Kd value for tryptophan and the Ki value for indolepyruvate by 31- and 17-fold, respectively, while having an only 2-fold effect on the Ki value for indoleacetamide. Both mutations increase the value of the primary deuterium isotope effect with tryptophan as a substrate, consistent with a later transition state. Both mutant enzymes catalyze a simple oxidase reaction, producing indolepyruvate and hydrogen peroxide. The pH dependences of the V/Ktrp values for the mutant enzymes show that the anionic form of the substrate is preferred but that the zwitterionic form is a substrate. The results are consistent with the interaction between Arg98 and the carboxylate of the amino acid substrate being critical for correct positioning of the substrate in the active site for efficient catalysis. PMID:14636049

  4. Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.

    PubMed

    Yamashita-Sugahara, Yzumi; Tokuzawa, Yoshimi; Nakachi, Yutaka; Kanesaki-Yatsuka, Yukiko; Matsumoto, Masahito; Mizuno, Yosuke; Okazaki, Yasushi

    2013-02-15

    This report identifies a novel gene encoding Fam57b (family with sequence similarity 57, member B) as a novel peroxisome proliferator-activated receptor γ (PPARγ)-responsive transmembrane gene that is related to obesity. The gene was identified based on an integrated bioinformatics analysis of the following three expression profiling data sets: adipocyte differentiation of mouse stromal cells (ST2 cells), adipose tissues from obesity mice, and siRNA-mediated knockdown of Pparγ using ST2 cells. Fam57b consists of three variants expressed from different promoters and contains a Tram-Lag1-CLN8 domain that is related to ceramide synthase. Reporter and ChIP assays showed that Fam57b variant 2 is a bona fide PPARγ target gene in ST2 cells. Fam57b was up-regulated during adipocyte differentiation, suggesting that FAM57B is involved in this process. Surprisingly, FAM57B overexpression inhibited adipogenesis, and siRNA-mediated knockdown promoted adipocyte differentiation. Analysis of the ceramide content by lipid assay found that ceramides were in fact augmented in FAM57B-overexpressing ST2 cells. We also confirmed that ceramide inhibits adipogenesis. Therefore, the aforementioned results of FAM57B overexpression and siRNA experiments are reconciled by ceramide synthesis. In summary, we present in vitro evidence showing that PPARγ regulates Fam57b transcription during the adipogenesis of ST2 cells. In addition, our results suggest that PPARγ activation contributes to the regulation of ceramide metabolism during adipogenesis via FAM57B. PMID:23275342

  5. Results of community deliberation about social impacts of ecological restoration: comparing public input of self-selected versus actively engaged community members.

    PubMed

    Harris, Charles C; Nielsen, Erik A; Becker, Dennis R; Blahna, Dale J; McLaughlin, William J

    2012-08-01

    Participatory processes for obtaining residents' input about community impacts of proposed environmental management actions have long raised concerns about who participates in public involvement efforts and whose interests they represent. This study explored methods of broad-based involvement and the role of deliberation in social impact assessment. Interactive community forums were conducted in 27 communities to solicit public input on proposed alternatives for recovering wild salmon in the Pacific Northwest US. Individuals identified by fellow residents as most active and involved in community affairs ("AE residents") were invited to participate in deliberations about likely social impacts of proposed engineering and ecological actions such as dam removal. Judgments of these AE participants about community impacts were compared with the judgments of residents motivated to attend a forum out of personal interest, who were designated as self-selected ("SS") participants. While the magnitude of impacts rated by SS participants across all communities differed significantly from AE participants' ratings, in-depth analysis of results from two community case studies found that both AE and SS participants identified a large and diverse set of unique impacts, as well as many of the same kinds of impacts. Thus, inclusion of both kinds of residents resulted in a greater range of impacts for consideration in the environmental impact study. The case study results also found that the extent to which similar kinds of impacts are specified by AE and SS group members can differ by type of community. Study results caution against simplistic conclusions drawn from this approach to community-wide public participation. Nonetheless, the results affirm that deliberative methods for community-based impact assessment involving both AE and SS residents can provide a more complete picture of perceived impacts of proposed restoration activities. PMID:22615108

  6. Results of Community Deliberation About Social Impacts of Ecological Restoration: Comparing Public Input of Self-Selected Versus Actively Engaged Community Members

    NASA Astrophysics Data System (ADS)

    Harris, Charles C.; Nielsen, Erik A.; Becker, Dennis R.; Blahna, Dale J.; McLaughlin, William J.

    2012-08-01

    Participatory processes for obtaining residents' input about community impacts of proposed environmental management actions have long raised concerns about who participates in public involvement efforts and whose interests they represent. This study explored methods of broad-based involvement and the role of deliberation in social impact assessment. Interactive community forums were conducted in 27 communities to solicit public input on proposed alternatives for recovering wild salmon in the Pacific Northwest US. Individuals identified by fellow residents as most active and involved in community affairs ("AE residents") were invited to participate in deliberations about likely social impacts of proposed engineering and ecological actions such as dam removal. Judgments of these AE participants about community impacts were compared with the judgments of residents motivated to attend a forum out of personal interest, who were designated as self-selected ("SS") participants. While the magnitude of impacts rated by SS participants across all communities differed significantly from AE participants' ratings, in-depth analysis of results from two community case studies found that both AE and SS participants identified a large and diverse set of unique impacts, as well as many of the same kinds of impacts. Thus, inclusion of both kinds of residents resulted in a greater range of impacts for consideration in the environmental impact study. The case study results also found that the extent to which similar kinds of impacts are specified by AE and SS group members can differ by type of community. Study results caution against simplistic conclusions drawn from this approach to community-wide public participation. Nonetheless, the results affirm that deliberative methods for community-based impact assessment involving both AE and SS residents can provide a more complete picture of perceived impacts of proposed restoration activities.

  7. Heavy Duty Vehicle Futures Analysis.

    SciTech Connect

    Askin, Amanda Christine; Barter, Garrett.; West, Todd H.; Manley, Dawn Kataoka

    2014-05-01

    This report describes work performed for an Early Career Research and Development project. This project developed a heavy-duty vehicle (HDV) sector model to assess the factors influencing alternative fuel and efficiency technology adoption. This model builds on a Sandia light duty vehicle sector model and provides a platform for assessing potential impacts of technological advancements developed at the Combustion Research Facility. Alternative fuel and technology adoption modeling is typically developed around a small set of scenarios. This HDV sector model segments the HDV sector and parameterizes input values, such as fuel prices, efficiencies, and vehicle costs. This parameterization enables sensitivity and trade space analyses to identify the inputs that are most associated with outputs of interest, such as diesel consumption and greenhouse gas emissions. Thus this analysis tool enables identification of the most significant HDV sector drivers that can be used to support energy security and climate change goals.

  8. Incidence of Campylobacter infections among service members of the active and reserve components of the U.S. Armed Forces and among other beneficiaries of the Military Health System, 2000-2013.

    PubMed

    2014-12-01

    This report reviews the incidence of illness due to Campylobacter bacteria based on diagnoses recorded in healthcare records and reported through the Armed Forces reportable medical event (RME) system. During 2000-2013, incident cases of Campylobacter infection were diagnosed in 1,393 active component service members, 188 members of the reserve component, and 3,891 retirees and family members. Among members of the active component, incidence rates tended to be higher among females, those aged 40 years or older, members of the Army and Air Force, and offi cers. Incidence rates declined from 2002 through 2007 but have risen steadily since, especially from 2010 through 2013. Among retirees and family members, the highest numbers of cases were diagnosed among those aged 5 years or younger and those aged 75 years or older. Cases identifi ed through RME reports (n=2,938) showed the highest numbers of cases in May-August, especially July, and that cases reported from Fort Shafter, HI, accounted for 20% of all cases. Measures and precautions important in preventing Campylobacter infections as well as other food- and waterborne infections are discussed. PMID:25555210

  9. Operation Duties on the F-15B Research Testbed

    NASA Technical Reports Server (NTRS)

    Truong, Samson S.

    2010-01-01

    This presentation entails what I have done this past summer for my Co-op tour in the Operations Engineering Branch. Activities included supporting the F-15B Research Testbed, supporting the incoming F-15D models, design work, and other operations engineering duties.

  10. Teaching Students about Their Civic Obligation--Jury Duty.

    ERIC Educational Resources Information Center

    Engelhardt, Leah T.; Steinbrink, John E.

    2001-01-01

    Contends that early adolescents need to learn how the jury trial system works. Provides background information on the topic for teachers. Includes a two-day lesson plan on jury duty as a civic obligation, background information for students, and extension activities relating to jury trials in the appendix. (CMK)

  11. Experiences of Military Youth during a Family Member's Deployment: Changes, Challenges, and Opportunities

    ERIC Educational Resources Information Center

    Knobloch, Leanne K.; Pusateri, Kimberly B.; Ebata, Aaron T.; McGlaughlin, Patricia C.

    2015-01-01

    The deployment of a family member can be very distressing for military children, but it also can supply opportunities for growth. This study addresses calls for research on the changes, challenges, and opportunities facing youth during a family member's tour of duty. It uses the relational turbulence model to frame research questions about how…

  12. Automobile or Other Conveyance and Adaptive Equipment Certificate of Eligibility for Veterans or Members of the Armed Forces With Amyotrophic Lateral Sclerosis Connected to Military Service. Final rule.

    PubMed

    2016-01-13

    The Department of Veterans Affairs (VA) published an Interim Final Rule on February 25, 2015, to amend its adjudication regulations to provide a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment for all veterans with service-connected amyotrophic lateral sclerosis (ALS) and servicemembers serving on active duty with ALS. The amendment authorized automatic issuance of a certificate of eligibility for financial assistance in the purchase of an automobile or other conveyance and adaptive equipment to all veterans with service-connected ALS and members of the Armed Forces serving on active duty with ALS. The intent of this final rule is to confirm the amendment made by the interim final rule without change. PMID:26761955

  13. Staff Members as Lifelong Learners.

    ERIC Educational Resources Information Center

    Stern, Joanne V.

    Based on the assumption that all community college staff members should be lifelong learners, this paper outlines the purposes and principles underlying a quality staff development program and enumerates the elements, activities, incentives, and other considerations that are necessary for the program to be successful. First, the purposes of staff…

  14. 40 CFR 86.1818-12 - Greenhouse gas emission standards for light-duty vehicles, light-duty trucks, and medium-duty...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CFR 85.502, of all model year light-duty vehicles, light-duty trucks, and medium-duty passenger... passenger automobile as that term is defined in 49 CFR 523.4. (2) Light truck means a motor vehicle that is... Provisions for Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks,...

  15. 40 CFR 86.1818-12 - Greenhouse gas emission standards for light-duty vehicles, light-duty trucks, and medium-duty...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CFR 85.502, of all model year light-duty vehicles, light-duty trucks, and medium-duty passenger... passenger automobile as that term is defined in 49 CFR 523.4. (2) Light truck means a motor vehicle that is... Provisions for Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks,...

  16. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... States upon the termination of assignment to extended duty at a post or station outside the Customs territory of the United States; (2) Members of his family who have resided with him at such post or station... and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  17. 12 CFR 717.91 - Duties of card issuers regarding changes of address.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AFFECTING CREDIT UNIONS FAIR CREDIT REPORTING Identity Theft Red Flags § 717.91 Duties of card issuers regarding changes of address. (a) Scope. This section applies to an issuer of a debit or credit card (card... means a member who has been issued a credit or debit card. (2) Clear and conspicuous means...

  18. 12 CFR 717.91 - Duties of card issuers regarding changes of address.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AFFECTING CREDIT UNIONS FAIR CREDIT REPORTING Identity Theft Red Flags § 717.91 Duties of card issuers regarding changes of address. (a) Scope. This section applies to an issuer of a debit or credit card (card... means a member who has been issued a credit or debit card. (2) Clear and conspicuous means...

  19. 12 CFR 717.91 - Duties of card issuers regarding changes of address.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AFFECTING CREDIT UNIONS FAIR CREDIT REPORTING Identity Theft Red Flags § 717.91 Duties of card issuers regarding changes of address. (a) Scope. This section applies to an issuer of a debit or credit card (card... means a member who has been issued a credit or debit card. (2) Clear and conspicuous means...

  20. 12 CFR 717.91 - Duties of card issuers regarding changes of address.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AFFECTING CREDIT UNIONS FAIR CREDIT REPORTING Identity Theft Red Flags § 717.91 Duties of card issuers regarding changes of address. (a) Scope. This section applies to an issuer of a debit or credit card (card... means a member who has been issued a credit or debit card. (2) Clear and conspicuous means...

  1. 75 FR 30371 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Advance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... Mermelstein (202) 482-1391. Japan (A-588-046) (3rd Review). Petroleum Wax Candles from Jennifer Moats (202... Countervailing Duty Orders; Policy Bulletin, 63 FR 18871 (April 16, 1998) . The Notice of Initiation of Five-Year... receives a Notice of Intent to Participate from a member of the domestic industry within 15 days of...

  2. 33 CFR 5.29 - Assignment to duty on a motorboat, yacht, aircraft, or radio station.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., yacht, aircraft, or radio station. 5.29 Section 5.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.29 Assignment to duty on a motorboat, yacht, aircraft, or radio station. No member of the Auxiliary shall be placed in charge of a motorboat,...

  3. 33 CFR 5.29 - Assignment to duty on a motorboat, yacht, aircraft, or radio station.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., yacht, aircraft, or radio station. 5.29 Section 5.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.29 Assignment to duty on a motorboat, yacht, aircraft, or radio station. No member of the Auxiliary shall be placed in charge of a motorboat,...

  4. 33 CFR 5.29 - Assignment to duty on a motorboat, yacht, aircraft, or radio station.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., yacht, aircraft, or radio station. 5.29 Section 5.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.29 Assignment to duty on a motorboat, yacht, aircraft, or radio station. No member of the Auxiliary shall be placed in charge of a motorboat,...

  5. 33 CFR 5.29 - Assignment to duty on a motorboat, yacht, aircraft, or radio station.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., yacht, aircraft, or radio station. 5.29 Section 5.29 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.29 Assignment to duty on a motorboat, yacht, aircraft, or radio station. No member of the Auxiliary shall be placed in charge of a motorboat,...

  6. 29 CFR 1620.20 - Pay differentials claimed to be based on extra duties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... paid sex also perform extra duties requiring equal skill, effort, and responsibility; (c) The proffered... peripheral importance; or (e) Third persons (i.e., individuals who are not in the two groups of employees being compared) who do the extra task as their primary job are paid less than the members of the...

  7. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  8. 19 CFR 148.74 - Exemption on termination of assignment to extended duty or on evacuation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... assignment to extended duty or on evacuation. (a) Exemption. With the limitation on alcoholic beverages and... possession of the claimant, or a member of his household, while abroad. (c) Limitation on alcoholic beverages and tobacco products. A total of not more than 4 liters of alcoholic beverages and not more than...

  9. Collapsable seal member

    SciTech Connect

    Sherrell, Dennis L.

    1990-01-01

    A hollow, collapsable seal member normally disposed in a natural expanded state offering fail-safe pressure sealing against a seating surface and adapted to be evacuated by a vacuum force for collapsing the seal member to disengage the same from said seating surface.

  10. Collapsable seal member

    SciTech Connect

    Sherrell, D.L.

    1983-12-08

    A hollow, collapsable seal member normally disposed in a natural expanded state offering fail-safe pressure sealing against a seating surface and adapted to be evacuated by a vacuum force for collapsing the seal member to disengage the same from said seating surface.

  11. Genome-wide identification and expression analysis of the mitogen-activated protein kinase gene family from banana suggest involvement of specific members in different stages of fruit ripening.

    PubMed

    Asif, Mehar Hasan; Lakhwani, Deepika; Pathak, Sumya; Bhambhani, Sweta; Bag, Sumit K; Trivedi, Prabodh Kumar

    2014-03-01

    Mitogen-activated protein kinases (MAPKs) are important components of the tripartite mitogen-activated protein kinase signaling cascade and play an important role in plant growth and development. Although members of the MAPK gene family have been identified in model plants, little information is available regarding this gene family in fruit crops. In this study, we carried out a computational analysis using the Musa Genome database to identify members of the MAPK gene family in banana, an economically important crop and the most popular fruit worldwide. Our analysis identified 25 members of the MAP kinase (MAPK or MPK) gene family. Phylogenetic analyses of MPKs in Arabidopsis, Oryza, and Populus have classified these MPKs into four subgroups. The presence of conserved domains in the deduced amino acid sequences, phylogeny, and genomic organization strongly support their identity as members of the MPK gene family. Expression analysis during ethylene-induced banana fruit ripening suggests the involvement of several MPKs in the ethylene signal transduction pathway that are necessary for banana fruit ripening. Analysis of the cis-regulatory elements in the promoter regions and the involvement of the identified MPKs in various cellular processes, as analyzed using Pathway Studio, suggest a role for the banana MPK gene family in diverse functions related to growth, development, and the stress response. This report is the first concerning the identification of members of a gene family and the elucidation of their role in various processes using the Musa Genome database. PMID:24275941

  12. [On the moral dutifulness of using vaccinations].

    PubMed

    Refolo, P; González-Melado, F J; Di Pietro, M L

    2015-01-01

    People had contradictory opinions on using vaccinations over time: an initial opposition, later large favour and then doubts and perplexities. In recent times, some movements, blogs and associations stigmatize the use of vaccinations and they are increasingly asking to remove mandatory vaccinations in countries where they are active. The impact of the antivaccination campaigns should not be underestimated, considering that, for example, in Italy, due to these campaigns, adhesions to vaccinations are decreasing by 1% per year, and in reference to rubella and measles, adhesions decreased by 25% in some regions of the country. Overcoming the choice between mandatory and recommended vaccinations, the paper deals with the topic of using preventive immunization starting from the concept of "moral dutifulness". PMID:25756259

  13. Guidelines for return to duty (play) after heat illness: a military perspective.

    PubMed

    O'Connor, Francis G; Williams, Aaron D; Blivin, Steve; Heled, Yuval; Deuster, Patricia; Flinn, Scott D

    2007-08-01

    Since Biblical times, heat injuries have been a major focus of military medical personnel. Heat illness accounts for considerable morbidity during recruit training and remains a common cause of preventable nontraumatic exertional death in the United States military. This brief report describes current regulations used by Army, Air Force, and Navy medical personnel to return active duty warfighters who are affected by a heat illness back to full duty. In addition, a description of the profile system used in evaluating the different body systems, and how it relates to military return to duty, are detailed. Current guidelines require clinical resolution, as well as a profile that that protects a soldier through repeated heat cycles, prior to returning to full duty. The Israeli Defense Force, in contrast, incorporates a heat tolerance test to return to duty those soldiers afflicted by heat stroke, which is briefly described. Future directions for U.S. military medicine are discussed. PMID:17923729

  14. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  15. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  16. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  17. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  18. 7 CFR 1207.328 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN Potato Research and Promotion Plan National Potato Promotion Board § 1207.328 Duties. The Board...

  19. Understanding the Code: the duty of candour.

    PubMed

    Griffith, Richard

    2015-08-01

    A key recommendation of the Mid Staffordshire Inquiry (Francis, 2013) was to establish a culture of openness in all health services through a duty of candour. A professional duty of candour is a key requirement of the Nursing and Midwifery Council's revised Code (2015). It requires all district nurses to be candid with patients about any errors in their care and treatment. District nurses working in England are also subject to a statutory duty of candour imposed on their employer by the Care Quality Commission. In this article, the author considers the organisational and professional duties of candour and their effect on a district nurse's practice. PMID:26252239

  20. High duty cycle hard soldered kilowatt laser diode arrays

    NASA Astrophysics Data System (ADS)

    Klumel, Genady; Karni, Yoram; Oppenheim, Jacob; Berk, Yuri; Shamay, Moshe; Tessler, Renana; Cohen, Shalom

    2010-02-01

    High-brightness laser diode arrays operating at a duty cycle of 10% - 20% are in ever-increasing demand for the optical pumping of solid state lasers and directed energy applications. Under high duty-cycle operation at 10% - 20%, passive (conductive) cooling is of limited use, while micro-coolers using de-ionized cooling water can considerably degrade device reliability. When designing and developing actively-cooled collimated laser diode arrays for high duty cycle operation, three main problems should be carefully addressed: an effective local and total heat removal, a minimization of packaging-induced and operational stresses, and high-precision fast axis collimation. In this paper, we present a novel laser diode array incorporating a built-in tap water cooling system, all-hard-solder bonded assembly, facet-passivated high-power 940 nm laser bars and tight fast axis collimation. By employing an appropriate layout of water cooling channels, careful choice of packaging materials, proper design of critical parts, and active optics alignment, we have demonstrated actively-cooled collimated laser diode arrays with extended lifetime and reliability, without compromising their efficiency, optical power density, brightness or compactness. Among the key performance benchmarks achieved are: 150 W/bar optical peak power at 10% duty cycle, >50% wallplug efficiency and <1° collimated fast axis divergence. A lifetime of >0.5 Ghots with <2% degradation has been experimentally proven. The laser diode arrays have also been successfully tested under harsh environmental conditions, including thermal cycling between -20°C and 40°C and mechanical shocks at 500g acceleration. The results of both performance and reliability testing bear out the effectiveness and robustness of the manufacturing technology for high duty-cycle laser arrays.

  1. 76 FR 18153 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... The People's Republic of China: Activated Carbon A-570-904 4/1/10-3/31/11 Certain Steel Threaded Rod A...: Assessment of Antidumping Duties, 68 FR 23954 (May 6, 2003), the Department has clarified its practice...

  2. The Economics of Perception: Potential Effect regarding Institutional Uses of Recovered Facilities and Administrative Costs upon a Faculty Member's Decision to Engage in Sponsored Research Activity

    ERIC Educational Resources Information Center

    Hatfield, Anne Elizabeth

    2012-01-01

    There is one aspect of sponsored research associated with higher education's research enterprise that often places the institution's research administrators and the institution's faculty members in conflict with each other; the recovery of Facilities and Administrative (F&A) costs associated with sponsored research projects (Sedwick, 2009;…

  3. AGU lost members

    NASA Astrophysics Data System (ADS)

    Mail to the following members has been returned, and we are unable to locate forwarding addresses. If you have information on any of them, please contact AGU by mail or call toll free at 800-424-2488.

  4. Banking and Financial Services Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for five occupations in the banking and financial services series. Each occupation is divided into seven or eight duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has been…

  5. Business & Office Accounting/Bookkeeping Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for five occupations in the business and office accounting/bookkeeping series. Each occupation is divided into four to six duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular duty has…

  6. 19 CFR 141.2 - Liability for duties on reimportation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Liability for duties on reimportation. 141.2 Section 141.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY OF MERCHANDISE Liability for Duties and Requirement To Enter Merchandise § 141.2 Liability for duties...

  7. 19 CFR 141.2 - Liability for duties on reimportation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Liability for duties on reimportation. 141.2 Section 141.2 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY OF MERCHANDISE Liability for Duties and Requirement To Enter Merchandise § 141.2 Liability for duties...

  8. 19 CFR 159.38 - Rates for estimated duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Rates for estimated duties. 159.38 Section 159.38... TREASURY (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.38 Rates for estimated duties. For purposes of calculating estimated duties, the port director shall use the rate or...

  9. 33 CFR 5.25 - Honorary members.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Honorary members. 5.25 Section 5.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.25 Honorary members. For conspicuous service to or active interest in the Auxiliary,...

  10. 29 CFR 785.15 - On duty.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false On duty. 785.15 Section 785.15 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR... On duty. A stenographer who reads a book while waiting for dictation, a messenger who works...

  11. 29 CFR 785.15 - On duty.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false On duty. 785.15 Section 785.15 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR... On duty. A stenographer who reads a book while waiting for dictation, a messenger who works...

  12. 29 CFR 785.15 - On duty.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false On duty. 785.15 Section 785.15 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR... On duty. A stenographer who reads a book while waiting for dictation, a messenger who works...

  13. 7 CFR 987.30 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling California Date Administrative Committee § 987.30 Duties. The Committee shall have, among other things, the following duties: (a) To act as intermediary... and to give to the Secretary the same notice of meetings of the Committee as is given to the...

  14. 7 CFR 983.45 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NEW MEXICO Administrative Committee § 983.45 Duties. The committee shall have, among others, the... or contract with such persons or agents as the committee deems necessary and to determine the duties... transactions of the committee and which shall be subject to examination by the Secretary; (f) To...

  15. 7 CFR 966.35 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Duties. 966.35 Section 966.35 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Order Regulating Handling Committee § 966.35 Duties. It...

  16. 7 CFR 966.35 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Duties. 966.35 Section 966.35 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Order Regulating Handling Committee § 966.35 Duties. It...

  17. 7 CFR 966.35 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Duties. 966.35 Section 966.35 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Order Regulating Handling Committee § 966.35 Duties. It...

  18. 7 CFR 966.35 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Duties. 966.35 Section 966.35 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Order Regulating Handling Committee § 966.35 Duties. It...

  19. 7 CFR 966.35 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Duties. 966.35 Section 966.35 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Order Regulating Handling Committee § 966.35 Duties. It...

  20. 14 CFR 221.2 - Carrier's duty.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Carrier's duty. 221.2 Section 221.2 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS General § 221.2 Carrier's duty. (a) Must file tariffs. (1) Except as provided in...

  1. 14 CFR 221.2 - Carrier's duty.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Carrier's duty. 221.2 Section 221.2 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS General § 221.2 Carrier's duty. (a) Must file tariffs. (1) Except as provided in...

  2. 7 CFR 1205.332 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the Secretary, a program of research, advertising, and sales promotion projects, together with a... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.332 Duties. The Board shall have the following duties:...

  3. 7 CFR 1205.332 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE COTTON RESEARCH AND PROMOTION Cotton Research and Promotion Order Cotton Board § 1205.332 Duties. The Board shall have the following duties: (a... Secretary, to enter into contracts or agreements for the development and submission to it of research...

  4. Light Duty Truck Aftertreatment - Experience and Challenges

    SciTech Connect

    Redon, Fabien

    2000-08-20

    Detroit Diesel's test experience on light duty truck PM aftertreatment technology development will be presented. The Tier-II extremely low emissions standards combined with the light-duty test cycle impose a significant challenge for the development of production-viable emissions technologies. A robust general path to achieve these emissions targets will be outlined.

  5. Individual rights versus societal duties.

    PubMed

    Vermeersch, E

    1999-10-29

    In 'bioethics', the rights to self-determination and to informed consent of the patient are prerequisites to every medical decision: paternalism is no longer a justifiable attitude. Hence, it seems that compulsory vaccination is an unacceptable praxis. Even John Stuart Mill. however, took into account other values: e.g. the duty not to harm others. This article is dedicated to the analysis of the historical development of these values and to their relevance for the ethics of vaccination. The acceptability of coercion is upheld, but no clear-cut answers are given in general: in every case the pros and cons of coercion are to be weighed carefully against each other. PMID:10627239

  6. Automatic control of clock duty cycle

    NASA Technical Reports Server (NTRS)

    Feng, Xiaoxin (Inventor); Roper, Weston (Inventor); Seefeldt, James D. (Inventor)

    2010-01-01

    In general, this disclosure is directed to a duty cycle correction (DCC) circuit that adjusts a falling edge of a clock signal to achieve a desired duty cycle. In some examples, the DCC circuit may generate a pulse in response to a falling edge of an input clock signal, delay the pulse based on a control voltage, adjust the falling edge of the input clock signal based on the delayed pulse to produce an output clock signal, and adjust the control voltage based on the difference between a duty cycle of the output clock signal and a desired duty cycle. Since the DCC circuit adjusts the falling edge of the clock cycle to achieve a desired duty cycle, the DCC may be incorporated into existing PLL control loops that adjust the rising edge of a clock signal without interfering with the operation of such PLL control loops.

  7. Severe neuropsychiatric reaction in a deployed military member after prophylactic mefloquine.

    PubMed

    Peterson, Alan L; Seegmiller, Robert A; Schindler, Libby S

    2011-01-01

    Recent studies of military personnel who have deployed to Iraq and Afghanistan have reported a number of combat-related psychiatric disorders such as posttraumatic stress disorder, depression, and traumatic brain injury. This case report involves a 27-year-old male active-duty US military service member who developed severe depression, psychotic hallucinations, and neuropsychological sequelae following the prophylactic use of the antimalarial medication mefloquine hydrochloride. The patient had a recent history of depression and was taking antidepressant medications at the time of his deployment to the Middle East. Psychiatrists and other health care providers should be aware of the possible neuropsychiatric side effects of mefloquine in deployed military personnel and should consider the use of other medications for malaria prophylaxis in those individuals who may be at increased risk for side effects. PMID:22937403

  8. Stress in service members.

    PubMed

    Lande, R Gregory

    2014-12-01

    Military service differs from civilian jobs in the stressors that service members experience, including frequent deployments (eg, to an area of combat operations), obedience, regimentation, subordination of self to the group, integrity, and flexibility. The military culture emphasizes teamwork and peer support. In some cases, service members cannot adapt to military life, become overwhelmed by stress, or cannot overcome a traumatic experience. Clinicians should conduct a thorough evaluation guided by an understanding of the military culture. Every effort should be made to identify the stress and the maladaptive response and provide early clinical interventions to prevent progression. PMID:25455065

  9. Suicides and suicide attempts among active component members of the U.S. Armed Forces, 2010-2012; methods of self-harm vary by major geographic region of assignment.

    PubMed

    Corr, William P

    2014-10-01

    This report analyzed data from the Department of Defense Suicide Event Report program about suicide events (suicide attempts and suicides) among active component service members during 2010-2012. Most attempts (85.2%) and suicides (83.5%) occurred among service members stationed in the U.S. Drugs were identified as the method of self-harm in 54.8% of attempts but in only 3.6% of suicides. Firearms were the leading method of suicide in both the U.S. and combat zones (61.1% and 97.2%, respectively) but accounted for only 5.4% of suicides in those stationed in Europe/Asia. Hanging/asphyxiation (22.9% overall) was the second most common method in suicides. For suicides using firearms, the rates of suicide and the types of firearm used varied according to service members' geographically related access to firearms. Challenges to reducing the frequency of service member suicides by firearms are discussed. PMID:25357138

  10. 41 CFR 303-70.303 - When an immediate family member, residing with the employee, dies while in transit to or from the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false When an immediate family member, residing with the employee, dies while in transit to or from the employee's duty station OCONUS... employee, dies while in transit to or from the employee's duty station OCONUS, must we furnish...

  11. 41 CFR 303-70.403 - When a family member, residing with the employee, dies while in transit to or from the employee's...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true When a family member, residing with the employee, dies while in transit to or from the employee's duty station outside CONUS... Members § 303-70.403 When a family member, residing with the employee, dies while in transit to or...

  12. 41 CFR 303-70.403 - When a family member, residing with the employee, dies while in transit to or from the employee's...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false When a family member, residing with the employee, dies while in transit to or from the employee's duty station outside CONUS... Members § 303-70.403 When a family member, residing with the employee, dies while in transit to or...

  13. 41 CFR 303-70.403 - When a family member, residing with the employee, dies while in transit to or from the employee's...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false When a family member, residing with the employee, dies while in transit to or from the employee's duty station outside CONUS... Members § 303-70.403 When a family member, residing with the employee, dies while in transit to or...

  14. 41 CFR 303-70.403 - When a family member, residing with the employee, dies while in transit to or from the employee's...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false When a family member, residing with the employee, dies while in transit to or from the employee's duty station outside CONUS... Members § 303-70.403 When a family member, residing with the employee, dies while in transit to or...

  15. Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity*

    PubMed Central

    Thomé, Carolina H.; dos Santos, Guilherme A.; Ferreira, Germano A.; Scheucher, Priscila S.; Izumi, Clarice; Leopoldino, Andreia M.; Simão, Ana Maria; Ciancaglini, Pietro; de Oliveira, Kleber T.; Chin, Alice; Hanash, Samir M.; Falcão, Roberto P.; Rego, Eduardo M.; Greene, Lewis J.; Faça, Vitor M.

    2012-01-01

    Lipid rafts are highly ordered membrane domains rich in cholesterol and sphingolipids that provide a scaffold for signal transduction proteins; altered raft structure has also been implicated in cancer progression. We have shown that 25 μm 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate (ODPC), an alkylphospholipid, targets high cholesterol domains in model membranes and induces apoptosis in leukemia cells but spares normal hematopoietic and epithelial cells under the same conditions. We performed a quantitative (SILAC) proteomic screening of ODPC targets in a lipid-raft-enriched fraction of leukemic cells to identify early events prior to the initiation of apoptosis. Six proteins, three with demonstrated palmitoylation sites, were reduced in abundance. One, the linker for activation of T-cell family member 2 (LAT2), is an adaptor protein associated with lipid rafts in its palmitoylated form and is specifically expressed in B lymphocytes and myeloid cells. Interestingly, LAT2 is not expressed in K562, a cell line more resistant to ODPC-induced apoptosis. There was an early loss of LAT2 in the lipid-raft-enriched fraction of NB4 cells within 3 h following treatment with 25 μm ODPC. Subsequent degradation of LAT2 by proteasomes was observed. Twenty-five μm ODPC inhibited AKT activation via myeloid growth factors, and LAT2 knockdown in NB4 cells by shRNA reproduced this effect. LAT2 knockdown in NB4 cells also decreased cell proliferation and increased cell sensitivity to ODPC (7.5×), perifosine (3×), and arsenic trioxide (8.5×). Taken together, these data indicate that LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID:23001822

  16. Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.

    PubMed

    Thomé, Carolina H; dos Santos, Guilherme A; Ferreira, Germano A; Scheucher, Priscila S; Izumi, Clarice; Leopoldino, Andreia M; Simão, Ana Maria; Ciancaglini, Pietro; de Oliveira, Kleber T; Chin, Alice; Hanash, Samir M; Falcão, Roberto P; Rego, Eduardo M; Greene, Lewis J; Faça, Vitor M

    2012-12-01

    Lipid rafts are highly ordered membrane domains rich in cholesterol and sphingolipids that provide a scaffold for signal transduction proteins; altered raft structure has also been implicated in cancer progression. We have shown that 25 μm 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate (ODPC), an alkylphospholipid, targets high cholesterol domains in model membranes and induces apoptosis in leukemia cells but spares normal hematopoietic and epithelial cells under the same conditions. We performed a quantitative (SILAC) proteomic screening of ODPC targets in a lipid-raft-enriched fraction of leukemic cells to identify early events prior to the initiation of apoptosis. Six proteins, three with demonstrated palmitoylation sites, were reduced in abundance. One, the linker for activation of T-cell family member 2 (LAT2), is an adaptor protein associated with lipid rafts in its palmitoylated form and is specifically expressed in B lymphocytes and myeloid cells. Interestingly, LAT2 is not expressed in K562, a cell line more resistant to ODPC-induced apoptosis. There was an early loss of LAT2 in the lipid-raft-enriched fraction of NB4 cells within 3 h following treatment with 25 μm ODPC. Subsequent degradation of LAT2 by proteasomes was observed. Twenty-five μm ODPC inhibited AKT activation via myeloid growth factors, and LAT2 knockdown in NB4 cells by shRNA reproduced this effect. LAT2 knockdown in NB4 cells also decreased cell proliferation and increased cell sensitivity to ODPC (7.5×), perifosine (3×), and arsenic trioxide (8.5×). Taken together, these data indicate that LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID:23001822

  17. Mistakes Board Members Make.

    ERIC Educational Resources Information Center

    Caruso, Nicholas D., Jr.

    2001-01-01

    Board members should avoid 10 common errors: losing patience, behaving badly, challenging the board after a vote, acting like inspectors, micromanaging school administrators, springing surprise questions at meetings, putting politics before children, representing special interests, violating executive session, and putting the board before family…

  18. 19 CFR 4.64 - Electronic passenger and crew member departure manifests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... manifests. 4.64 Section 4.64 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY VESSELS IN FOREIGN AND DOMESTIC TRADES Foreign Clearances § 4.64... is required for active duty U.S. military personnel on board a departing Department of...

  19. 78 FR 19645 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-02

    ...: Activated Carbon A-570-904 4/1/12-3/31/13 Frontseating Service Valves A-570-933 4/1/12-3/31/13 1... Antidumping and Countervailing Duty Proceedings: Assessment of Antidumping Duties, 68 FR 23954 (May 6, 2003... Procedures, 76 FR 39263 (July 6, 2011). Further, in accordance with 19 CFR 351.303(f)(l)(i), a copy of...

  20. Constraining duty cycles through a Bayesian technique

    NASA Astrophysics Data System (ADS)

    Romano, P.; Guidorzi, C.; Segreto, A.; Ducci, L.; Vercellone, S.

    2014-12-01

    The duty cycle (DC) of astrophysical sources is generally defined as the fraction of time during which the sources are active. It is used to both characterize their central engine and to plan further observing campaigns to study them. However, DCs are generally not provided with statistical uncertainties, since the standard approach is to perform Monte Carlo bootstrap simulations to evaluate them, which can be quite time consuming for a large sample of sources. As an alternative, considerably less time-consuming approach, we derived the theoretical expectation value for the DC and its error for sources whose state is one of two possible, mutually exclusive states, inactive (off) or flaring (on), as based on a finite set of independent observational data points. Following a Bayesian approach, we derived the analytical expression for the posterior, the conjugated distribution adopted as prior, and the expectation value and variance. We applied our method to the specific case of the inactivity duty cycle (IDC) for supergiant fast X-ray transients, a subclass of flaring high mass X-ray binaries characterized by large dynamical ranges. We also studied IDC as a function of the number of observations in the sample. Finally, we compare the results with the theoretical expectations. We found excellent agreement with our findings based on the standard bootstrap method. Our Bayesian treatment can be applied to all sets of independent observations of two-state sources, such as active galactic nuclei, X-ray binaries, etc. In addition to being far less time consuming than bootstrap methods, the additional strength of this approach becomes obvious when considering a well-populated class of sources (Nsrc ≥ 50) for which the prior can be fully characterized by fitting the distribution of the observed DCs for all sources in the class, so that, through the prior, one can further constrain the DC of a new source by exploiting the information acquired on the DC distribution derived

  1. Ascofuranone stimulates expression of adiponectin and peroxisome proliferator activated receptor through the modulation of mitogen activated protein kinase family members in 3T3-L1, murine pre-adipocyte cell line

    SciTech Connect

    Chang, Young-Chae; Cho, Hyun-Ji

    2012-06-08

    Highlights: Black-Right-Pointing-Pointer Ascofuranone increases expression of adiponectin and PPAR{gamma}. Black-Right-Pointing-Pointer Inhibitors for MEK and JNK increased the expression of adiponectin and PPAR{gamma}. Black-Right-Pointing-Pointer Ascofuranone significantly suppressed phosho-ERK, while increasing phospho-p38. -- Abstract: Ascofuranone, an isoprenoid antibiotic, was originally isolated as a hypolipidemic substance from a culture broth of the phytopathogenic fungus, Ascochyta visiae. Adiponectin is mainly synthesized by adipocytes. It relieves insulin resistance by decreasing the plasma triglycerides and improving glucose uptake, and has anti-atherogenic properties. Here, we found that ascofuranone increases expression of adiponectin and PPAR{gamma}, a major transcription factor for adiponectin, in 3T3-L1, murine pre-adipocytes cell line, without promoting accumulation of lipid droplets. Ascofuranone induced expression of adiponectin, and increases the promoter activity of adiponectin and PPRE, PPAR response element, as comparably as a PPAR{gamma} agonist, rosiglitazone, that stimulates lipid accumulation in the preadipocyte cell line. Moreover, inhibitors for MEK and JNK, like ascofuranone, considerably increased the expression of adiponectin and PPAR{gamma}, while a p38 inhibitor significantly suppressed. Ascofuranone significantly suppressed ERK phosphorylation, while increasing p38 phosphorylation, during adipocyte differentiation program. These results suggest that ascofuranone regulates the expression of adiponectin and PPAR{gamma} through the modulation of MAP kinase family members.

  2. 26 CFR 1.121-5 - Suspension of 5-year period for certain members of the uniformed services and Foreign Service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... official extended duty as a member of the Foreign Service of the United States in Brazil. In 2015 B sells... period of ownership and use during his 8-year period of service with the Foreign Service in Brazil. If...

  3. 26 CFR 1.121-5 - Suspension of 5-year period for certain members of the uniformed services and Foreign Service.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... official extended duty as a member of the Foreign Service of the United States in Brazil. In 2015 B sells... period of ownership and use during his 8-year period of service with the Foreign Service in Brazil. If...

  4. 26 CFR 1.121-5 - Suspension of 5-year period for certain members of the uniformed services and Foreign Service.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... official extended duty as a member of the Foreign Service of the United States in Brazil. In 2015 B sells... period of ownership and use during his 8-year period of service with the Foreign Service in Brazil. If...

  5. 26 CFR 1.121-5 - Suspension of 5-year period for certain members of the uniformed services and Foreign Service.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... official extended duty as a member of the Foreign Service of the United States in Brazil. In 2015 B sells... period of ownership and use during his 8-year period of service with the Foreign Service in Brazil. If...

  6. 26 CFR 1.121-5 - Suspension of 5-year period for certain members of the uniformed services and Foreign Service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... official extended duty as a member of the Foreign Service of the United States in Brazil. In 2015 B sells... period of ownership and use during his 8-year period of service with the Foreign Service in Brazil. If...

  7. Mitogen-activated protein kinase kinase kinase (MAPKKK) 4 from rapeseed (Brassica napus L.) is a novel member inducing ROS accumulation and cell death.

    PubMed

    Li, Liang; Ye, Chaofei; Zhao, Rui; Li, Xin; Liu, Wu-zhen; Wu, Feifei; Yan, Jingli; Jiang, Yuan-Qing; Yang, Bo

    2015-11-27

    MAPKKK is the largest family of MAPK cascade, which is known to play important roles in plant growth, development and immune responses. So far, only a few have been functionally characterized even in the model plant, Arabidopsis due to the potential functional redundancy of MAPKKK. We previously identified and cloned a few MAPKKK family genes from rapeseed. In this study, BnaMAPKKK4 was characterized as a member in eliciting accumulation of reactive oxygen species (ROS) and hypersensitive response (HR)-like cell death. This is accompanied with accumulation of malondialdehyde (MDA), anthocyanin as well as nuclear DNA fragmentation. The transcript abundance of a series of ROS accumulation, cell death, and defense response related genes were up-regulated by the expression of MAPKKK4. Further investigation identified BnaMAPKKK4 elicited ROS through the downstream MPK3. These results indicate that BnaMAPKKK4 and its downstream components function in the ROS-induced cell death. PMID:26498521

  8. Fitness for duty in the nuclear power industry

    SciTech Connect

    Durbin, N.; Moore, C.; Grant, T.; Fleming, T.; Hunt, P.; Martin, R.; Murphy, S.; Hauth, J.; Wilson, R.; Bittner, A.; Bramwell, A.; Macaulay, J.; Olson, J.; Terrill, E.; Toquam, J. )

    1991-09-01

    This report presents an overview of the NRC licensees' implementation of the FFD program during the first full year of the program's operation and provides new information on a variety of FFD technical issues. The purpose of this document is to contribute to appropriate changes to the rule, to the inspection process, and to other NRC activities. It describes the characteristics of licensee programs, discusses the results of NRC inspections, updates technical information covered in previous reports, and identifies lessons learned during the first year. Overall, the experience of the first full year of licensees' FFD program operations indicates that licensees have functioning fitness for duty programs devoted to the NRC rule's performance objectives of achieving drug-free workplaces in which nuclear power plant personnel are not impaired as they perform their duties. 96 refs., 14 tabs.

  9. SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

    PubMed Central

    2014-01-01

    Background The SPE-8 group gene products transduce the signal for spermatid activation initiated by extracellular zinc in C. elegans. Mutations in the spe-8 group genes result in hermaphrodite-derived spermatids that cannot activate to crawling spermatozoa, although spermatids from mutant males activate through a pathway induced by extracellular TRY-5 protease present in male seminal fluid. Results Here, we identify SPE-8 as a member of a large family of sperm-expressed non-receptor-like protein-tyrosine kinases. A rescuing SPE-8::GFP translational fusion reporter localizes to the plasma membrane in all spermatogenic cells from the primary spermatocyte stage through spermatids. Once spermatids become activated to spermatozoa, the reporter moves from the plasma membrane to the cytoplasm. Mutations in the spe-8 group genes spe-12, spe-19, and spe-27 disrupt localization of the reporter to the plasma membrane, while localization appears near normal in a spe-29 mutant background. Conclusions These results suggest that the SPE-8 group proteins form a functional complex localized at the plasma membrane, and that SPE-8 is correctly positioned only when all members of the SPE-8 group are present, with the possible exception of SPE-29. Further, SPE-8 is released from the membrane when the activation signal is transduced into the spermatid. PMID:25022984

  10. Supporting Members and Friends

    NASA Astrophysics Data System (ADS)

    2005-10-01

    Thank you! Over the past year, AGU has received 12,104 gifts, both large and small, from members and friends. The Union has also received corporate contributions, National Science Foundation grants, and support from the National Oceanographic Partnership Program and National Association of Geoscience Teachers. Together their generosity has benefited AGU non revenue producing programs that are critical to our science and the future health of the Union. The following list gratefully acknowledges annual gifts of $100 or more and cumulative giving of $5,000 or more. The 1919 Society ($100,000 or more) and Benefactors ($5,000-$99,999) recognize single major gifts and cumulative contributions. Three circles acknowledge annual giving: President's Circle ($1,000 or more), Leadership Circle ($200-$999), and Supporters Circle ($100-$199). Supporting Life Members, who contribute a one-time gift of $1,200 in addition to lifetime dues, are among our most loyal Supporters.

  11. Supporting Members and Friends

    NASA Astrophysics Data System (ADS)

    2004-09-01

    Thank you! Over the past 20 months AGU has received a record 22,159 gifts, both large and small, from members and friends. The Union has also received corporate contributions, National Science Foundation grants, and support from four federal agencies (NASA, NOAA, EPA, and USGS). Together their generosity has benefited AGU non-revenue producing programs that are critical to our science and the future health of the Union. The following list gratefully acknowledges annual gifts of $100 or more and cumulative giving of $5000 or more. The 1919 Society ($100,000+) and Benefactors ($5,000-$99,999) recognize single major and cumulative contributions. Three circles acknowledge annual giving: President's Circle ($1,000 or more), Leadership Circle ($250-$999), and Supporters Circle ($100-$249). Supporting Life Members, who contribute a one-time gift of $1,200 in addition to lifetime dues, are recognized as our most loyal Supporters.

  12. 7 CFR 906.31 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... things, the duty of the committee: (a) At the beginning of each term of office, to meet and organize, to... fidelity bonds for all persons handling funds; (f) To investigate from time to time and to assemble data...

  13. 29 CFR 541.106 - Concurrent duties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) For example, an assistant manager in a retail establishment may perform work such as serving customers... not preclude the exemption if the assistant manager's primary duty is management. An assistant...

  14. 7 CFR 915.29 - Duties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulating Handling Administrative Body § 915.29 Duties. The committee shall have, among others, the... with any one meeting of the committee; and (n) To investigate compliance with the provisions of...

  15. 7 CFR 915.29 - Duties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulating Handling Administrative Body § 915.29 Duties. The committee shall have, among others, the... with any one meeting of the committee; and (n) To investigate compliance with the provisions of...

  16. 7 CFR 915.29 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulating Handling Administrative Body § 915.29 Duties. The committee shall have, among others, the... with any one meeting of the committee; and (n) To investigate compliance with the provisions of...

  17. 7 CFR 915.29 - Duties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulating Handling Administrative Body § 915.29 Duties. The committee shall have, among others, the... with any one meeting of the committee; and (n) To investigate compliance with the provisions of...

  18. 7 CFR 915.29 - Duties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulating Handling Administrative Body § 915.29 Duties. The committee shall have, among others, the... with any one meeting of the committee; and (n) To investigate compliance with the provisions of...

  19. 38 CFR 3.6 - Duty periods.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... from an injury incurred or aggravated in line of duty or from an acute myocardial infarction, a cardiac... means any of the following: (i) An acute myocardial infarction. (ii) A cardiac arrest. (iii)...

  20. 38 CFR 3.6 - Duty periods.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... from an injury incurred or aggravated in line of duty or from an acute myocardial infarction, a cardiac... means any of the following: (i) An acute myocardial infarction. (ii) A cardiac arrest. (iii)...

  1. 38 CFR 3.6 - Duty periods.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... from an injury incurred or aggravated in line of duty or from an acute myocardial infarction, a cardiac... means any of the following: (i) An acute myocardial infarction. (ii) A cardiac arrest. (iii)...

  2. 38 CFR 3.6 - Duty periods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... from an injury incurred or aggravated in line of duty or from an acute myocardial infarction, a cardiac... means any of the following: (i) An acute myocardial infarction. (ii) A cardiac arrest. (iii)...

  3. 38 CFR 3.6 - Duty periods.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... from an injury incurred or aggravated in line of duty or from an acute myocardial infarction, a cardiac... means any of the following: (i) An acute myocardial infarction. (ii) A cardiac arrest. (iii)...

  4. Ethics, pandemics, and the duty to treat.

    PubMed

    Malm, Heidi; May, Thomas; Francis, Leslie P; Omer, Saad B; Salmon, Daniel A; Hood, Robert

    2008-08-01

    Numerous grounds have been offered for the view that healthcare workers have a duty to treat, including expressed consent, implied consent, special training, reciprocity (also called the social contract view), and professional oaths and codes. Quite often, however, these grounds are simply asserted without being adequately defended or without the defenses being critically evaluated. This essay aims to help remedy that problem by providing a critical examination of the strengths and weaknesses of each of these five grounds for asserting that healthcare workers have a duty to treat, especially as that duty would arise in the context of an infectious disease pandemic. Ultimately, it argues that none of the defenses is currently sufficient to ground the kind of duty that would be needed in a pandemic. It concludes by sketching some practical recommendations in that regard. PMID:18802849

  5. 34 CFR 300.169 - Duties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DISABILITIES State Eligibility State Advisory Panel § 300.169 Duties. The advisory panel must— (a) Advise the... Office of Management and Budget under control number 1820-0030) (Authority: 20 U.S.C....

  6. Surrogacy, rights and duties: a partial commentary.

    PubMed

    Campbell, A V

    2000-01-01

    In response to criticisms of proposed regulation of surrogacy, it is argued that surrogate mothers and providers of fertility services have duties which make the selling of claims to parenthood unethical and which justify regulation of surrogacy arrangements. PMID:10977159

  7. 49 CFR 272.5 - General duty.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRANSPORTATION CRITICAL INCIDENT STRESS PLANS General § 272.5 General duty. A railroad subject to this part shall adopt a written critical incident stress plan approved by the Federal Railroad Administration...

  8. Handwriting and a nurse's duty of care.

    PubMed

    Griffith, Richard

    2016-06-01

    Richard Griffith, Senior Lecturer in Health Law, Swansea University, considers the professional duty of nurses to write clearly and highlights the financial and human cost of poor handwriting. PMID:27281599

  9. 19 CFR 134.2 - Additional duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COUNTRY OF ORIGIN MARKING General Provisions § 134.2 Additional duties. Articles not marked as required by... container) to indicate the English name of the country of origin of the article or to include words...

  10. AGU members win Fulbrights

    NASA Astrophysics Data System (ADS)

    Six AGU members have been awarded Fulbright grants to lecture or conduct research abroad during the current (1985-1986) academic year, according to the Council for International Exchange of Scholars, which helps to administer the Fulbright Scholar Program.James R. Barcus, a professor of physics at the University of Denver, is lecturing and doing research in thunderstorm coupling in global electricity at Catholic University in Lima, Peru, from January through June 1986.

  11. Duty hour restrictions: organizational dynamics, systems issues, and the impact on faculty.

    PubMed

    Bandiera, Glen; Hynes, Melissa Kennedy; Spadafora, Salvatore M

    2014-01-01

    The potential impact of resident duty hour restrictions on faculty is likely significant; however, the extent of this impact has still not been well documented. We undertook a narrative review of the literature to determine the magnitude of that potential impact and the nature of the evolving discourse related to faculty members as individuals. The literature provides an inconsistent picture of the impact of duty hour restrictions on faculty. While some studies have reported a significant increase in faculty workload, others suggest that the impact of duty hour restrictions has been minimal. Some papers suggest that duty hour restrictions may fundamentally change the nature of resident-teacher interactions and, as a result, will necessitate significant changes to the way education is delivered. Overall, the majority of issues of concern relate to one of the following: volume and composition of work, impact on faculty career choice, evolving perceptions of residents as learners, and the need to find an appropriate balance between learning and the quality and quantity of patient care. In describing these themes we identify some potential solutions and future directions for reconciling duty hour restrictions with faculty perceptions, anxieties, and desired outcomes. PMID:25558952

  12. [Comment on] BOSP members

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    The new Board on Ocean Science and Policy (BOSP) (Eos, June 7, 1983, p. 402) met for the first time on May 4. John B. Slaughter, former director of the National Science Foundation and now chancellor of the University of Maryland in College Park, is the board's chairman. Other board members are D. James Baker, Jr. (University of Washington, Seattle); Kirk Bryan (Geophysical Fluid Dynamics Laboratory, Princeton University); John P. Craven (University of Hawaii); Charles L. Drake (Dartmouth College); Paul M. Fye (Woods Hole Oceanographic Institution); Edward D. Goldberg (Scripps Institution of Oceanography); G. Ross Heath (Oregon State University); Judith T. Kildow (Massachusetts Institute of Technology); John A. Knauss (University of Rhode Island); James J. McCarthy (Museum of Comparative Zoology, Harvard University); H. William Menard (Scripps Institution of Oceanography); C. Barry Raleigh (Lamont-Doherty Geological Observatory); Roger Revelle (University of California, San Diego); David A. Ross (Woods Hole Oceanographic Institution); Brian J. Rothschild (University of Maryland); William M. Sackett (University of South Florida); John H. Steele (Woods Hole Oceanographic Institution); and Carl Wunsch (MIT). Wallace Broecker (Lamont-Doherty Geological Observatory), an original board member, resigned after the first meeting. Broecker told Eos that combining the science and policy boards resulted in a new board whose mission is too broad. A new board member will be appointed in Broecker's place

  13. Towards a Duty of Care for Biodiversity

    NASA Astrophysics Data System (ADS)

    Earl, G.; Curtis, A.; Allan, C.

    2010-04-01

    The decline in biodiversity is a worldwide phenomenon, with current rates of species extinction more dramatic than any previously recorded. Habitat loss has been identified as the major cause of biodiversity decline. In this article we suggest that a statutory duty of care would complement the current mix of policy options for biodiversity conservation. Obstacles hindering the introduction of a statutory duty of care include linguistic ambiguity about the terms ‘duty of care’ and ‘stewardship’ and how they are applied in a natural resource management context, and the absence of a mechanism to guide its implementation. Drawing on international literature and key informant interviews we have articulated characteristics of duty of care to reduce linguistic ambiguity, and developed a framework for implementing a duty of care for biodiversity at the regional scale. The framework draws on key elements of the common law ‘duty of care’, the concepts of ‘taking reasonable care’ and ‘avoiding foreseeable harm’, in its logic. Core elements of the framework include desired outcomes for biodiversity, supported by current recommended practices. The focus on outcomes provides opportunities for the development of innovative management practices. The framework incorporates multiple pathways for the redress of non-compliance including tiered negative sanctions, and positive measures to encourage compliance. Importantly, the framework addresses the need for change and adaptation that is a necessary part of biodiversity management.

  14. 19 CFR 10.625 - Refunds of excess customs duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Refunds of excess customs duties. 10.625 Section 10.625 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... and Apparel Goods § 10.625 Refunds of excess customs duties. (a) Applicability. Section 205 of...

  15. 19 CFR 12.62 - Enforcement; duties of Customs officers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Enforcement; duties of Customs officers. 12.62 Section 12.62 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...; duties of Customs officers. (a) In accordance with the authority contained in sections 10 and 12 of...

  16. 19 CFR 191.144 - Refund of duties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Refund of duties. 191.144 Section 191.144 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.144 Refund of duties. Drawback shall be refunded...

  17. Marketing Education/Business Management & Ownership Series. Duty Task List.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This document contains the occupational duty/task lists for eight occupations in the marketing education/business management and ownership series. Each occupation is divided into 4 to 12 duties. A separate page for each duty in the occupation lists the tasks in that duty along with its code number and columns to indicate whether that particular…

  18. 19 CFR 10.80 - Remission of duty; withdrawal; bond.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Remission of duty; withdrawal; bond. 10.80 Section 10.80 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... for Curing Fish § 10.80 Remission of duty; withdrawal; bond. Imported salt in bond may be used...

  19. 19 CFR 151.66 - Duty on samples.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Duty on samples. 151.66 Section 151.66 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.66 Duty on samples....

  20. 19 CFR 151.66 - Duty on samples.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Duty on samples. 151.66 Section 151.66 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.66 Duty on samples....