Science.gov

Sample records for active living research

  1. Partnerships for progress in active living: from research to action

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The theme for the 2011 Active Living Research Annual Conference was "Partnerships for Progress in Active Living: From Research to Action." The rationale for this theme was simple: no person is an island. The theme recognizes that partnerships are essential to identify and implement solutions for co...

  2. Steps toward validity in active living research: research design that limits accusations of physical determinism.

    PubMed

    Riggs, William

    2014-03-01

    "Active living research" has been accused of being overly "physically deterministic" and this article argues that urban planners must continue to evolve research and address biases in this area. The article first provides background on how researchers have dealt with the relationship between the built environment and health over years. This leads to a presentation of how active living research might be described as overly deterministic. The article then offers lessons for researchers planning to embark in active-living studies as to how they might increase validity and minimize criticism of physical determinism.

  3. Embedding a Recovery Orientation into Neuroscience Research: Involving People with a Lived Experience in Research Activity.

    PubMed

    Stratford, Anthony; Brophy, Lisa; Castle, David; Harvey, Carol; Robertson, Joanne; Corlett, Philip; Davidson, Larry; Everall, Ian

    2016-03-01

    This paper highlights the importance and value of involving people with a lived experience of mental ill health and recovery in neuroscience research activity. In this era of recovery oriented service delivery, involving people with the lived experience of mental illness in neuroscience research extends beyond their participation as "subjects". The recovery paradigm reconceptualises people with the lived experience of mental ill health as experts by experience. To support this contribution, local policies and procedures, recovery-oriented training for neuroscience researchers, and dialogue about the practical applications of neuroscience research, are required.

  4. Translating active living research into policy and practice: one important pathway to chronic disease prevention.

    PubMed

    Giles-Corti, Billie; Sallis, James F; Sugiyama, Takemi; Frank, Lawrence D; Lowe, Melanie; Owen, Neville

    2015-05-01

    Global concerns about rising levels of chronic disease make timely translation of research into policy and practice a priority. There is a need to tackle common risk factors: tobacco use, unhealthy diets, physical inactivity, and harmful alcohol use. Using evidence to inform policy and practice is challenging, often hampered by a poor fit between academic research and the needs of policymakers and practitioners--notably for active living researchers whose objective is to increase population physical activity by changing the ways cities are designed and built. We propose 10 strategies that may facilitate translation of research into health-enhancing urban planning policy. Strategies include interdisciplinary research teams of policymakers and practitioners; undertaking explicitly policy-relevant research; adopting appropriate study designs and methodologies (evaluation of policy initiatives as 'natural experiments'); and adopting dissemination strategies that include knowledge brokers, advocates, and lobbyists. Conducting more policy-relevant research will require training for researchers as well as different rewards in academia.

  5. Active living research: creating and using evidence to support childhood obesity prevention.

    PubMed

    Sallis, James F; Cutter, Carmen L; Lou, Deborah; Spoon, Chad; Wilson, Amanda L; Ding, Ding; Ponkshe, Prabhu; Cervero, Robert; Patrick, Kevin; Schmid, Thomas L; Mignano, Alexandra; Orleans, C Tracy

    2014-02-01

    The second phase of Active Living Research (ALR-2, 2007-2012) focused on advancing the Robert Wood Johnson Foundation (RWJF)'s goal of reversing the childhood obesity epidemic. The mission was to stimulate and support research to identify environmental factors and policies that influence physical activity for children and families to inform effective childhood obesity prevention strategies, with an emphasis on the lower-income and racial/ethnic communities with highest childhood obesity prevalence. The present report describes ALR activities undertaken to accomplish three goals. The first goal-to build an evidence base-was furthered by funding 230 competitive grants to identify and evaluate promising environment and policy changes. More than 300 publications have been produced so far. The second goal-to build an interdisciplinary and diverse field of investigators-was supported through annual conferences and linked journal supplements, academic outreach to multiple disciplines, and grants targeting young investigators and those representing groups historically disadvantaged or underrepresented in RWJF-funded research. The third goal-to use research to inform policy and practice-was advanced through research briefs; webinars; research-translation grants supporting ALR grantees to design communications tailored to decision-maker audiences; active engagement of policymakers and other stakeholders in ALR program meetings and annual conferences; ALR presentations at policy-related meetings; and broad outreach through a widely used website, e-mailed newsletters, and social media. ALR-2 findings and products have contributed to a rapid increase in the evidence base and field of active living research, as documented by an independent program evaluation.

  6. Rural Active Living: A Call to Action.

    PubMed

    Umstattd Meyer, M Renée; Moore, Justin B; Abildso, Christiaan; Edwards, Michael B; Gamble, Abigail; Baskin, Monica L

    2016-01-01

    Rural residents are less physically active than their urban counterparts and disproportionately affected by chronic diseases and conditions associated with insufficient activity. While the ecological model has been successful in promoting and translating active living research in urban settings, relatively little research has been conducted in rural settings. The resulting research gap prohibits a comprehensive understanding and application of solutions for active living in rural America. Therefore, the purpose of this article was to assess the evidence base for an ecological model of active living for rural populations and outline key scientific gaps that inhibit the development and application of solutions. Specifically, we reexamined the 4 domains conceptualized by the model and suggest that there is a dearth of research specific to rural communities across all areas of the framework. Considering the limited rural-specific efforts, we propose areas that need addressing to mobilize rural active living researchers and practitioners into action.

  7. Physical Activity Assessment Between Consumer- and Research-Grade Accelerometers: A Comparative Study in Free-Living Conditions

    PubMed Central

    Winfree, Kyle N; Pohlig, Ryan T; Papas, Mia A

    2016-01-01

    Background Wearable activity monitors such as Fitbit enable users to track various attributes of their physical activity (PA) over time and have the potential to be used in research to promote and measure PA behavior. However, the measurement accuracy of Fitbit in absolute free-living conditions is largely unknown. Objective To examine the measurement congruence between Fitbit Flex and ActiGraph GT3X for quantifying steps, metabolic equivalent tasks (METs), and proportion of time in sedentary activity and light-, moderate-, and vigorous-intensity PA in healthy adults in free-living conditions. Methods A convenience sample of 19 participants (4 men and 15 women), aged 18-37 years, concurrently wore the Fitbit Flex (wrist) and ActiGraph GT3X (waist) for 1- or 2-week observation periods (n=3 and n=16, respectively) that included self-reported bouts of daily exercise. Data were examined for daily activity, averaged over 14 days and for minutes of reported exercise. Average day-level data included steps, METs, and proportion of time in different intensity levels. Minute-level data included steps, METs, and mean intensity score (0 = sedentary, 3 = vigorous) for overall reported exercise bouts (N=120) and by exercise type (walking, n=16; run or sports, n=44; cardio machine, n=20). Results Measures of steps were similar between devices for average day- and minute-level observations (all P values > .05). Fitbit significantly overestimated METs for average daily activity, for overall minutes of reported exercise bouts, and for walking and run or sports exercises (mean difference 0.70, 1.80, 3.16, and 2.00 METs, respectively; all P values < .001). For average daily activity, Fitbit significantly underestimated the proportion of time in sedentary and light intensity by 20% and 34%, respectively, and overestimated time by 3% in both moderate and vigorous intensity (all P values < .001). Mean intensity scores were not different for overall minutes of exercise or for run or

  8. Promoting healthy diets and active lives to hard-to-reach groups: market research study.

    PubMed

    White, S L; Maloney, S K

    1990-01-01

    Continued progress over the next decade in reducing premature morbidity and mortality from chronic disease will require that health communication efforts target a significant proportion of the American public that has not been influenced by the health promotion efforts of the 1980s. Focus groups conducted with members of the hard-to-reach American public showed that while being healthy seemed to be important to participants, and they were generally aware of what to do to stay healthy, they had a different operational definition of health than that used in health promotion programs. Participants seemed to believe that better health behaviors would build their resistance to acute illnesses, that is, keep them healthy, but that chronic diseases, such as cancer and diabetes, were due to fate and heredity and beyond their individual control. The focus group results show that participants had not made the link between chronic disease prevention and the importance of diet, exercise, and weight control. Although most of them seemed to express a genuine interest in "doing better," they were not able to supply more than superficial examples of how such changes might be made. Surprisingly, there were more similarities than differences in participants' attitudes and beliefs, with the similarities cutting across boundaries of race-ethnicity, age, and sex. Interest in changing behaviors was only slightly more pronounced among female rather than male, and older rather than younger, participants. However, there was not much evidence from the participants that they were actively seeking health information or trying to reconcile conflicting knowledge and beliefs.

  9. Teaching Activities of Daily Living.

    ERIC Educational Resources Information Center

    McCormack, James E.

    Provided are strategies for teaching activities of daily living (ADL), which include dressing, eating, grooming, toileting, and basic homemakine, to severely retarded students. Reviewed are the steps necessary to teach ADL skills: ADL assessment, identification of appropriate strategies and tactics, and task analysis. Explained are four common…

  10. Sport and Physical Activity in the Lives of Looked-After Children: A "Hidden Group" in Research, Policy and Practice

    ERIC Educational Resources Information Center

    Quarmby, Thomas

    2014-01-01

    Looked-after children are arguably one of the most disadvantaged groups in society and constitute a "hidden group" in relation to sport and physical activity research, policy and practice. Research on looked-after children has explored the views of caregivers, practitioners and policy-makers who have often been asked to speak for…

  11. Reflection on Lived Experience in Educational Research

    ERIC Educational Resources Information Center

    Barnacle, Robyn

    2004-01-01

    While debate about the meaning of hermeneutics and phenomenology for educational research continues, the notion of lived experience, and its application to reflective practice, has become a feature of much that goes by the name of phenomenological within this area. The prevalence of the lived experience model can be attributed in large part to the…

  12. Developing a Research Agenda for Assisted Living

    ERIC Educational Resources Information Center

    Kane, Rosalie A.; Wilson, Keren Brown; Spector, William

    2007-01-01

    Purpose: We describe an approach to identifying knowledge gaps, research questions, and methodological issues for assisted living (AL) research. Design and Methods: We undertook an inventory of AL literature and research in progress and commissioned background papers critiquing knowledge on selected subtopics. With an advisory committee, we…

  13. Teacher as Researcher: Teaching as Lived Research

    ERIC Educational Resources Information Center

    Binder, Marni

    2012-01-01

    Teacher inquiry can shape empirical inquiries by nonpracticing researchers, by allowing them to draw on the practical knowledge of those in the classroom. This recognition challenged the author to question what legitimized her role as a teacher-researcher and ask how she could have felt empowered as a researcher without higher education. In this…

  14. A living wage for research subjects.

    PubMed

    Phillips, Trisha B

    2011-01-01

    Offering cash payments to research subjects is a common recruiting method, but this practice continues to be controversial because of its potential to compromise the protection of human subjects. Federal regulations and guidelines currently allow researchers to pay subjects for participation, but they say very little about how much researchers can pay their subjects. This paper argues that the federal regulations and guidelines should implement a standard payment formula. It argues for a wage payment model, and critically examines three candidates for a base wage: the nonfarm production wage, the FLSA minimum wage, and a living wage. After showing that the nonfarm production wage is too high to satisfy ethical criteria, and the minimum wage is too low, this paper concludes that the wage payment model with a base wage equivalent to a living wage is the best candidate for a standard payment formula in human subjects research.

  15. Active living and injury risk.

    PubMed

    Parkkari, J; Kannus, P; Natri, A; Lapinleimu, I; Palvanen, M; Heiskanen, M; Vuori, I; Järvinen, M

    2004-04-01

    The purpose of this study was to get reliable insight into injury risk in various commuting and lifestyle activities, as well as recreational and competitive sports. A cohort of 3 657 persons was randomly selected from the 15- to 74-year-old Finnish population. Ninety-two percent (n = 3 363) of the subjects accepted to participate the one-year follow-up, record all their physical activities that lasted 15 min or more, and register all acute and overuse injuries that occurred during these activities. To collect the information, the study subjects were interviewed by phone by the trained personnel of the Statistics Finland three times in four-month intervals. The individual injury risk per exposure time was relatively low, ranging from 0.19 to 1.5 per 1 000 hours of participation, in commuting and lifestyle activities including walking and cycling to work, gardening, home repair, hunting and fishing, and, in sports such as golf, dancing, swimming, walking, and rowing. The risk was clearly higher in squash, orienteering, and contact and team sports, such as judo, wrestling, karate, rinkball, floorball, basketball, soccer, ice hockey, volleyball, and Finnish baseball ranging from 6.6 to 18.3 per 1 000 hours of participation. However, the highest absolute number of injuries occurred in low-risk activities, such as gardening, walking, home-repair, and cycling, because they are performed so often. In conclusion, individual injury risk per exposure hours is relatively low in commuting and lifestyle activities compared to many recreational and competitive sports. However, at a population level, these low-to-moderate intensity activities are widely practised producing a rather high absolute number of injuries, and thus, preventive efforts are needed in these activities, too.

  16. Research Activities.

    ERIC Educational Resources Information Center

    Santa Fe Community Coll., Gainesville, FL.

    The five parts of this report are: research on instruction; faculty dissertations; inter-institutional research; in-college research; and college-endorsed research. The first covers experiments in teaching French, practical nursing, English, math, and chemistry, and in giving examinations. Faculty dissertations include studies of post-graduate…

  17. Live Scale Active Shooter Exercise: Lessons Learned

    ERIC Educational Resources Information Center

    Ervin, Randy

    2008-01-01

    On October 23, 2007, the Lake Land College Public Safety Department conducted a full-scale live exercise that simulated an active shooter and barricaded hostage. In this article, the author will emphasize what they learned, and how they intend to benefit from it. He will list the law enforcement issues and general issues they encountered, and then…

  18. Citizens' visions on active assisted living.

    PubMed

    Gudowsky, Niklas; Sotoudeh, Mahshid

    2015-01-01

    People aged 65 years and older are the fastest growing section of the population in many countries. Great hopes are projected on technology to support solutions for many of the challenges arising from this trend, thus making our lives more independent, more efficient and safer with a higher quality of life. But, as research and innovation ventures are often closely linked to the market, their focus may lead to biased planning in research and development as well as in policy-making with severe social and economic consequences. Thus the main research question concerned desirable settings of ageing in the future from different perspectives. The participatory foresight study CIVISTI-AAL cross-linked knowledge of lay persons, experts and stakeholders to include a wide variety of perspectives and values into productive long-term planning of research and development. Results include citizens' visions for autonomous living in 2050, implicitly and explicitly containing basic needs towards technological, social and organizational development as well as recommendations for implementation. Conclusions suggest that personalized health and living environments play an important part in the lay persons' view of aging in the future, but only if technologies support social and organizational innovations and yet do not neglect the importance of social affiliation and inclusion.

  19. Lived Observations: Linking the Researcher's Personal Experiences to Knowledge Development.

    PubMed

    Thoresen, Lisbeth; Öhlén, Joakim

    2015-11-01

    As researchers in palliative care, we recognize how involvement with seriously ill and dying persons has an impact on us. Using one's own senses, emotional and bodily responses in observations might open intersubjective dimensions of the research topic. The aim of the article is to highlight how phenomenological theories on intersubjectivity can be useful to develop rich and transparent data generation and analysis. We present three field note examples from observation in a hospice ward, which illuminate how researcher awareness of aspects of intersubjectivity can add valuable insights to data and analysis. Out of the examples, we elaborate on three arguments: (a) how the researcher's lived experience of time and space during fieldwork triggers new research questions, (b) how observations as an embodied activity can bring new insights and open new layers of meaning, and (c) the value of observations in gaining insight into relational aspects in a hospice.

  20. Using Live Cases for Teaching, Industry Collaboration, and Research

    ERIC Educational Resources Information Center

    Laukkanen, Mikko; Mattila, Pekka; Salo, Jari; Tikkanen, Henrikki

    2013-01-01

    The use of live cases in marketing teaching has been suggested as a way to provide students with interesting and relevant course work while collaborating on live case exercises also provides industry partners with valuable new ideas for innovation and development. When properly conducted, live cases can also be used for conducting research by the…

  1. Bursts of Active Transport in Living Cells

    NASA Astrophysics Data System (ADS)

    Wang, Bo; Kuo, James; Granick, Steve

    2013-11-01

    We show, using a large new data set, that the temporally resolved speed of active cargo transport in living cells follows a scaling law over several decades of time and length. The statistical regularities display a time-averaged shape that we interpret to reflect stress buildup, followed by rapid release. The scaling power law agrees quantitatively with those reported in inanimate systems (jammed colloids and granular media, and magnetic Barkhausen noise), suggesting a common origin in pushing through a crowded environment in a weak force regime. The implied regulation of the speed of active cellular transport due to environmental obstruction results in bursts of speed and acceleration. These findings extend the classical notion of molecular crowding.

  2. Bursts of active transport in living cells.

    PubMed

    Wang, Bo; Kuo, James; Granick, Steve

    2013-11-15

    We show, using a large new data set, that the temporally resolved speed of active cargo transport in living cells follows a scaling law over several decades of time and length. The statistical regularities display a time-averaged shape that we interpret to reflect stress buildup, followed by rapid release. The scaling power law agrees quantitatively with those reported in inanimate systems (jammed colloids and granular media, and magnetic Barkhausen noise), suggesting a common origin in pushing through a crowded environment in a weak force regime. The implied regulation of the speed of active cellular transport due to environmental obstruction results in bursts of speed and acceleration. These findings extend the classical notion of molecular crowding.

  3. Roundtable on Urban Living Environment Research (RULER).

    PubMed

    Vlahov, David; Agarwal, Siddharth Raj; Buckley, Robert M; Caiaffa, Waleska Teixeira; Corvalan, Carlos F; Ezeh, Alex Chika; Finkelstein, Ruth; Friel, Sharon; Harpham, Trudy; Hossain, Maharufa; de Faria Leao, Beatriz; Mboup, Gora; Montgomery, Mark R; Netherland, Julie C; Ompad, Danielle C; Prasad, Amit; Quinn, Andrew T; Rothman, Alexander; Satterthwaite, David E; Stansfield, Sally; Watson, Vanessa J

    2011-10-01

    For 18 months in 2009-2010, the Rockefeller Foundation provided support to establish the Roundtable on Urban Living Environment Research (RULER). Composed of leading experts in population health measurement from a variety of disciplines, sectors, and continents, RULER met for the purpose of reviewing existing methods of measurement for urban health in the context of recent reports from UN agencies on health inequities in urban settings. The audience for this report was identified as international, national, and local governing bodies; civil society; and donor agencies. The goal of the report was to identify gaps in measurement that must be filled in order to assess and evaluate population health in urban settings, especially in informal settlements (or slums) in low- and middle-income countries. Care must be taken to integrate recommendations with existing platforms (e.g., Health Metrics Network, the Institute for Health Metrics and Evaluation) that could incorporate, mature, and sustain efforts to address these gaps and promote effective data for healthy urban management. RULER noted that these existing platforms focus primarily on health outcomes and systems, mainly at the national level. Although substantial reviews of health outcomes and health service measures had been conducted elsewhere, such reviews covered these in an aggregate and perhaps misleading way. For example, some spatial aspects of health inequities, such as those pointed to in the 2008 report from the WHO's Commission on the Social Determinants of Health, received limited attention. If RULER were to focus on health inequities in the urban environment, access to disaggregated data was a priority. RULER observed that some urban health metrics were already available, if not always appreciated and utilized in ongoing efforts (e.g., census data with granular data on households, water, and sanitation but with little attention paid to the spatial dimensions of these data). Other less obvious elements

  4. NIH's National Institute of Nursing Research Is Changing Lives

    MedlinePlus

    ... Current Issue Past Issues NIH's National Institute of Nursing Research Is Changing Lives Past Issues / Spring 2008 ... on. From childbirth to end-of-life care, nursing research is aimed at helping patients across the ...

  5. Living the Research: Stories from Homeless Youth.

    ERIC Educational Resources Information Center

    Norum, Karen E.

    There is an alarming trend in homelessness: children aged 17 and younger are the most rapidly growing group of the homeless; families continue to be a growing group of the homeless; and many people who are homeless were raised or have lived in the suburbs. Homelessness is no longer an inner-city phenomenon. Three homeless youth were interviewed…

  6. Researching Graduates' Lived Experiences of Vocational Learning

    ERIC Educational Resources Information Center

    Leach, Tony

    2012-01-01

    The aim of this article is to exemplify the value of using a phenomenological approach when investigating graduates' lived experiences of vocational learning. For this study, qualitative data was obtained during a series of email interviews with 35 participants. As a group they are highly aspirational and, during their graduate studies, were…

  7. Living science: Science as an activity of living beings.

    PubMed

    MacLennan, Bruce J

    2015-12-01

    The philosophy of science should accommodate itself to the facts of human existence, using all aspects of human experience to adapt more effectively, as individuals, species, and global ecosystem. This has several implications: (1) Our nature as sentient beings interacting with other sentient beings requires the use of phenomenological methods to investigate consciousness. (2) Our embodied, situated, purposeful physical interactions with the world are the foundation of scientific understanding. (3) Aristotle's four causes are essential for understanding living systems and, in particular, the final cause aids understanding the role of humankind, and especially science, in the global ecosystem. (4) In order to fulfill this role well, scientists need to employ the full panoply of human faculties. These include the consciousness faculties (thinking, sensation, feeling, intuition), and therefore, as advocated by many famous scientists, we should cultivate our aesthetic sense, emotions, imagination, and intuition. Our unconscious faculties include archetypal structures common to all humans, which can guide scientific discovery. By striving to engage the whole of human nature, science will fulfill better its function for humans and the global ecosystem.

  8. Transnational Lives in European Educational Research

    ERIC Educational Resources Information Center

    Lawn, Martin

    2014-01-01

    Transnational collaboration by educational researchers in Europe has grown fast since the mid-1990s and the means to support it have become more easily accessible. A study of the growth of the European Educational Research Association (EERA) since its foundation in the mid-1990s shows how transnational research in European education began, and how…

  9. Vestibular Function and Activities of Daily Living

    PubMed Central

    Harun, Aisha; Semenov, Yevgeniy R.; Agrawal, Yuri

    2015-01-01

    Objective: Vestibular dysfunction increases with age and is associated with mobility difficulties and fall risk in older individuals. We evaluated whether vestibular function influences the ability to perform activities of daily living (ADLs). Method: We analyzed the 1999 to 2004 National Health and Nutrition Examination Survey of adults aged older than 40 years (N = 5,017). Vestibular function was assessed with the Modified Romberg test. We evaluated the association between vestibular function and difficulty level in performing specific basic and instrumental ADLs, and total number of ADL impairments. Results: Vestibular dysfunction was associated with significantly higher odds of difficulty with nine ADLs, most strongly with difficulty managing finances (odds ratio [OR] = 2.64, 95% confidence interval [CI] = [1.18, 5.90]). In addition, vestibular dysfunction was associated with a significantly greater number of ADL impairments (β = .21, 95% CI = [0.09, 0.33]). This effect size was comparable with the influence of heavy smoking (β = .21, 95% CI = [0.06, 0.36]) and hypertension (β = .10, 95% CI = [0.02, 0.18]) on the number of ADL impairments. Conclusion: Vestibular dysfunction significantly influences ADL difficulty, most strongly with a cognitive rather than mobility-based task. These findings underscore the importance of vestibular inputs for both cognitive and physical daily activities. PMID:26753170

  10. Research Administration as a Living System

    ERIC Educational Resources Information Center

    Cole, Sharon Stewart

    2007-01-01

    The purpose of this Delphi study was to gather expert opinions and recommendations for change in the research administration system to bring about growth and collaboration. This study was deemed important because at the heart of every system is the fact that individuals need each other to continue to exist. The results of the Delphi study give…

  11. Kinase Activity Studied in Living Cells Using an Immunoassay

    ERIC Educational Resources Information Center

    Bavec, Aljos?a

    2014-01-01

    This laboratory exercise demonstrates the use of an immunoassay for studying kinase enzyme activity in living cells. The advantage over the classical method, in which students have to isolate the enzyme from cell material and measure its activity in vitro, is that enzyme activity is modulated and measured in living cells, providing a more…

  12. Activities report of PTT Research

    NASA Astrophysics Data System (ADS)

    In the field of postal infrastructure research, activities were performed on postcode readers, radiolabels, and techniques of operations research and artificial intelligence. In the field of telecommunication, transportation, and information, research was made on multipurpose coding schemes, speech recognition, hypertext, a multimedia information server, security of electronic data interchange, document retrieval, improvement of the quality of user interfaces, domotics living support (techniques), and standardization of telecommunication prototcols. In the field of telecommunication infrastructure and provisions research, activities were performed on universal personal telecommunications, advanced broadband network technologies, coherent techniques, measurement of audio quality, near field facilities, local beam communication, local area networks, network security, coupling of broadband and narrowband integrated services digital networks, digital mapping, and standardization of protocols.

  13. Happier People Live More Active Lives: Using Smartphones to Link Happiness and Physical Activity

    PubMed Central

    Lathia, Neal; Sandstrom, Gillian M.; Mascolo, Cecilia; Rentfrow, Peter J.

    2017-01-01

    Physical activity, both exercise and non-exercise, has far-reaching benefits to physical health. Although exercise has also been linked to psychological health (e.g., happiness), little research has examined physical activity more broadly, taking into account non-exercise activity as well as exercise. We examined the relationship between physical activity (measured broadly) and happiness using a smartphone application. This app has collected self-reports of happiness and physical activity from over ten thousand participants, while passively gathering information about physical activity from the accelerometers on users' phones. The findings reveal that individuals who are more physically active are happier. Further, individuals are happier in the moments when they are more physically active. These results emerged when assessing activity subjectively, via self-report, or objectively, via participants' smartphone accelerometers. Overall, this research suggests that not only exercise but also non-exercise physical activity is related to happiness. This research further demonstrates how smartphones can be used to collect large-scale data to examine psychological, behavioral, and health-related phenomena as they naturally occur in everyday life. PMID:28052069

  14. Music Is Key to Active, Happy Lives.

    ERIC Educational Resources Information Center

    Hoffman, Elizabeth

    1995-01-01

    Encapsulates a series of verbatim statements made by young musicians about the joy music has brought to their lives. The musicians, all students at Black Mountain Middle School in San Diego, California, exhibit a wide range of responses discussing their commitment, hard work, and sense of accomplishment. (MJP)

  15. Physical Environments of Assisted Living: Research Needs and Challenges

    ERIC Educational Resources Information Center

    Cutler, Lois J.

    2007-01-01

    Purpose: This article aims to review research measures and findings related to physical environments of assisted living (AL) according to multiple conceptual perspectives--ecological, cultural, and Maslovian hierarchy. Design and Methods: A literature and research review was undertaken with two foci: performance measures for physical environments,…

  16. Student Perceptions on Live-Case Projects: Undergraduate Marketing Research

    ERIC Educational Resources Information Center

    Gundala, Raghava Rao; Singh, Mandeep; Baldwin, Andrew

    2014-01-01

    This paper is an investigation into undergraduate students' perceptions on use of live projects as a teaching pedagogy in marketing research courses. Students in undergraduate marketing research courses from fall 2009 to spring 2013 completed an online questionnaire consisting of 17 items. The results suggested that student understanding of…

  17. Detection of amount and activity of living algae in fresh water by dehydrogenase activity (DHA).

    PubMed

    Xie, Jun; Hu, Wenrong; Pei, Haiyan; Dun, Mina; Qi, Feng

    2008-11-01

    A study was performed to determine the amount and activity of living algae in fresh water by measuring the dehydrogenase activity (DHA) of algae in order to provide a method to assess the effect of algicide treatment. The conditions of measurement were researched with respect to incubating temperature and duration, and selection of extractants. The comparison between this method and an alternative method, chlorophyll a, shows that this method is simple and easy to practice, and can determine the effect of algicide treatment.

  18. "Living" Ethical Dilemmas for Researchers When Researching with Children

    ERIC Educational Resources Information Center

    Mortari, Luigina; Harcourt, Deborah

    2012-01-01

    This article will explore some of the ethical dilemmas that confront researchers when they seek to invite children's participation in research. It firstly tracks the historical landscape of ethical research and will examine the influence of the United Nations Convention on the Rights of the Child (UNCRC) on participatory research with children.…

  19. Promoting active living in healthy cities of Europe.

    PubMed

    Faskunger, Johan

    2013-10-01

    Local governments in Europe have a vital role in promoting physical activity in the daily life of citizens. However, explicit investment in active living has been limited. One of the four core themes for Phase IV (2003-2008) of the World Health Organization (WHO) European Healthy Cities Network (WHO-EHCN) was to encourage local governments and their partners to implement programs in favor of active living. This study analyzes the performance of network cities during this period. Responses to a general evaluation questionnaire are analyzed by content according to a checklist, and categorized into themes and dimensions. Most cities viewed "active living" as an important issue for urban planning; to improve visual appeal, enhance social cohesion, create a more sustainable transport system to promote walkability and cyclability and to reduce inequalities in public health. Almost all member cities reported on existing policies that support the promotion of active living. However, only eight (of the 59) responding cities mentioned an integrated framework specific for active living. Many efforts to promote active living are nested in programs to prevent obesity among adults or children. Future challenges include establishing integrated policies specifically for active living, introducing a larger range of actions, as well as increasing funding and capacity to make a difference at the population level.

  20. Neuropathologic correlates of activities of daily living in Alzheimer disease.

    PubMed

    Marshall, Gad A; Fairbanks, Lynn A; Tekin, Sibel; Vinters, Harry V; Cummings, Jeffrey L

    2006-01-01

    Functional status, reflected by measures of activities of daily living (ADLs), deteriorates as Alzheimer disease (AD) progresses. Decline in activities of daily living may be mediated by executive and frontal lobe dysfunction. The objective of this study was to examine the relationship between activities of daily living and pathologic burden in Alzheimer disease. Twenty two subjects with definite Alzheimer disease were selected from the UCLA ADRC neuropathology database. A total activities of daily living score was derived from the Retrospective Collateral Dementia Interview-Revised (RCDI-R) questionnaire, which was administered to caregivers of autopsied subjects included in the study. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions. There was a significant positive correlation between total activities of daily living score (higher scores indicate more disability) and mean neuritic plaques and neurofibrillary tangle counts (r = 0.671, P = 0.001, and r = 0.542, P = 0.009, resp), as well as CA1 and prosubiculum neuritic plaques and neurofibrillary tangle counts, right and left orbital frontal neuritic plaques counts, and occipital neuritic plaques count. Total activities of daily living score did not correlate with age at death, age at symptom onset, dementia duration, gender, or education. Deteriorating activities of daily living in Alzheimer Disease subjects correlate with greater overall pathologic burden and possibly selectively with involvement of the medial temporal, occipital, and orbital frontal regions.

  1. The Living Experience of Feeling Overwhelmed: A Parse Research Study.

    PubMed

    Condon, Barbara Backer

    2014-07-01

    Feeling overwhelmed is a universal living experience of living quality. Although feeling overwhelmed frequently occurs in healthcare, studies related to its meaning have never been published. Parse's humanbecoming school of thought was the theoretical framework for this study. The research question for this study was: What is the structure of the living experience of feeling overwhelmed? The purpose was to advance nursing science and enhance the theory of humanbecoming. Parse's phenomenological-hermeneutic research method was the method used. Participants from the general population included nine women and one man ranging in age from 18 to 65. Descriptions were arrived at through dialogical engagement. The major finding of the study is the structure: Feeling overwhelmed is burdening disconcertedness surfacing with divergent engagements as optimistic anticipation arises while structuring endeavors.

  2. Activities of Daily Living of Spanish-Speaking Immigrants.

    ERIC Educational Resources Information Center

    Ailinger, Rita L.

    This anthropological study reports on some of the activities of daily living (ADL's) of 19 Spanish-speaking families living in a low income suburb of Washington, D.C. ADL's are defined as those functions which are performed on a usual day. Generically they include eating, sleeping, communicating, working, and recreating. In this paper, they…

  3. Manual of Alternative Procedures: Activities of Daily Living.

    ERIC Educational Resources Information Center

    McCormack, James E.; And Others

    Intended for teachers and others providing services for moderately and severely physically and/or mentally handicapped children and young adults, the manual presents strategies, procedures, and task analyses for training in daily living skills. Section I provides an overview of tactics for teaching activities of daily living (ADL) skills,…

  4. Learning from Our Lives: Women, Research, and Autobiography in Education.

    ERIC Educational Resources Information Center

    Neumann, Anna, Ed.; Peterson, Penelope L., Ed.

    The autobiographical essays in this volume offer insights into how the field of education might change as women assume positions of intellectual leadership. After the "Foreword" (Mary Catherine Bateson), the 13 chapters are: (1) "Research Lives: Women, Scholarship, and Autobiography in Education" (Anna Neumann and Penelope L.…

  5. Research progress in live attenuated Brucella vaccine development.

    PubMed

    Wang, Zhen; Wu, Qingmin

    2013-01-01

    Brucella spp. are facultative intracellular bacteria that cause brucellosis, which is a globally occurring zoonotic disease that is characterized by abortion in domestic animals and undulant fever, arthritis, endocarditis, and meningitis in humans. There are currently no licensed vaccines against brucellosis for human use, and only a few licensed live Brucella vaccines are available for use in animals. However, the available animal vaccines may cause abortion and are associated with lower protection rates in animals and higher virulence in humans. Much research has been performed recently to develop novel Brucella vaccines for the prevention and control of animal brucellosis. This article discusses the approaches and strategies for novel live attenuated vaccine development.

  6. Different categories of living and non-living sound-sources activate distinct cortical networks.

    PubMed

    Engel, Lauren R; Frum, Chris; Puce, Aina; Walker, Nathan A; Lewis, James W

    2009-10-01

    With regard to hearing perception, it remains unclear as to whether, or the extent to which, different conceptual categories of real-world sounds and related categorical knowledge are differentially represented in the brain. Semantic knowledge representations are reported to include the major divisions of living versus non-living things, plus more specific categories including animals, tools, biological motion, faces, and places-categories typically defined by their characteristic visual features. Here, we used functional magnetic resonance imaging (fMRI) to identify brain regions showing preferential activity to four categories of action sounds, which included non-vocal human and animal actions (living), plus mechanical and environmental sound-producing actions (non-living). The results showed a striking antero-posterior division in cortical representations for sounds produced by living versus non-living sources. Additionally, there were several significant differences by category, depending on whether the task was category-specific (e.g. human or not) versus non-specific (detect end-of-sound). In general, (1) human-produced sounds yielded robust activation in the bilateral posterior superior temporal sulci independent of task. Task demands modulated activation of left lateralized fronto-parietal regions, bilateral insular cortices, and sub-cortical regions previously implicated in observation-execution matching, consistent with "embodied" and mirror-neuron network representations subserving recognition. (2) Animal action sounds preferentially activated the bilateral posterior insulae. (3) Mechanical sounds activated the anterior superior temporal gyri and parahippocampal cortices. (4) Environmental sounds preferentially activated dorsal occipital and medial parietal cortices. Overall, this multi-level dissociation of networks for preferentially representing distinct sound-source categories provides novel support for grounded cognition models that may underlie

  7. Different categories of living and non-living sound-sources activate distinct cortical networks

    PubMed Central

    Engel, Lauren R.; Frum, Chris; Puce, Aina; Walker, Nathan A.; Lewis, James W.

    2009-01-01

    With regard to hearing perception, it remains unclear as to whether, or the extent to which, different conceptual categories of real-world sounds and related categorical knowledge are differentially represented in the brain. Semantic knowledge representations are reported to include the major divisions of living versus non-living things, plus more specific categories including animals, tools, biological motion, faces, and places—categories typically defined by their characteristic visual features. Here, we used functional magnetic resonance imaging (fMRI) to identify brain regions showing preferential activity to four categories of action sounds, which included non-vocal human and animal actions (living), plus mechanical and environmental sound-producing actions (non-living). The results showed a striking antero-posterior division in cortical representations for sounds produced by living versus non-living sources. Additionally, there were several significant differences by category, depending on whether the task was category-specific (e.g. human or not) versus non-specific (detect end-of-sound). In general, (1) human-produced sounds yielded robust activation in the bilateral posterior superior temporal sulci independent of task. Task demands modulated activation of left-lateralized fronto-parietal regions, bilateral insular cortices, and subcortical regions previously implicated in observation-execution matching, consistent with “embodied” and mirror-neuron network representations subserving recognition. (2) Animal action sounds preferentially activated the bilateral posterior insulae. (3) Mechanical sounds activated the anterior superior temporal gyri and parahippocampal cortices. (4) Environmental sounds preferentially activated dorsal occipital and medial parietal cortices. Overall, this multi-level dissociation of networks for preferentially representing distinct sound-source categories provides novel support for grounded cognition models that may

  8. Food for Healthy Living and Active Ageing.

    PubMed

    Ajmone Marsan, Paolo; Cocconcelli, Pier Sandro; Masoero, Francesco; Miggiano, Giacinto; Morelli, Lorenzo; Moro, Daniele; Rossi, Filippo; Sckokai, Paolo; Trevisi, Erminio

    2014-01-01

    The link between diet and health has been recognized since the Grecian period; as Hippocrates said, "Let food be your medicine and medicine be your food". Although the primary goals of diet are meeting nutritional requirements and providing energy, there is increasing awareness that a correct and balanced diet may prevent the insurgence of diet-related pathologies and/or improve well-being and life expectancy, also reflecting on the ageing process. Research on the interaction among nutrients, gut microbiota and host metabolism is presently unravelling the molecular mechanisms underlying the positive and negative effects of traditional diets on health and ageing, providing useful information for the design of innovative foods targeting specific needs and segments of the population. The food supply chain plays a key role in ensuring quality and safety through both comprehensive quality management and inspection systems and a focused innovation process mainly devoted to the creation of functional foods. However, innovation and scientific development pose a problem of information asymmetry towards final consumers; thus, regulatory aspects and private and public communication strategies must be efficiently developed.

  9. NASA Research Being Shared Through Live, Interactive Video Tours

    NASA Technical Reports Server (NTRS)

    Petersen, Ruth A.; Zona, Kathleen A.

    2001-01-01

    On June 2, 2000, the NASA Glenn Research Center Learning Technologies Project (LTP) coordinated the first live remote videoconferencing broadcast from a Glenn facility. The historic event from Glenn's Icing Research Tunnel featured wind tunnel technicians and researchers performing an icing experiment, obtaining results, and discussing the relevance to everyday flight operations and safety. After a brief overview of its history, students were able to "walk through" the tunnel, stand in the control room, and observe a live icing experiment that demonstrated how ice would grow on an airplane wing in flight through an icing cloud. The tour was interactive, with a spirited exchange of questions and explanations between the students and presenters. The virtual tour of the oldest and largest refrigerated icing research tunnel in the world was the second of a series of videoconferencing connections with the AP Physics students at Bay Village High School, Bay Village, Ohio. The first connection, called Aircraft Safety and Icing Research, introduced the Tailplane Icing Program. In an effort to improve aircraft safety by reducing the number of in-flight icing events, Glenn's Icing Branch uses its icing research aircraft to conduct flight tests. The presenter engaged the students in discussions of basic aircraft flight mechanics and the function of the horizontal tailplane, as well as the effect of ice on airfoil (wing or tail) surfaces. A brief video of actual flight footage provided a view of the pilot's actions and reactions and of the horizon during tailplane icing conditions.

  10. Physical Activity among Older People Living Alone in Shanghai, China

    ERIC Educational Resources Information Center

    Chen, Yu; While, Alison E; Hicks, Allan

    2015-01-01

    Objective: To investigate physical activity among older people living alone in Shanghai, People's Republic of China, and key factors contributing to their physical activity. Methods: A cross-sectional questionnaire survey was administered in nine communities in Shanghai, using a stratified random cluster sample: 521 community-dwelling older people…

  11. "Active Living" Related to the Rural-Urban Continuum: A Time-Use Perspective

    ERIC Educational Resources Information Center

    Millward, Hugh; Spinney, Jamie

    2011-01-01

    Purpose: This paper assesses the degree to which "active living" varies along the rural-urban continuum, within the county-sized regional municipality of Halifax, Nova Scotia. Methods: Time-diary data from the Halifax Space-Time Activity Research project were used to compute daily participation rates (PRs) and time durations, at various…

  12. 1998 Gordon Research Conference on Gravitational Effects on Living Systems

    NASA Technical Reports Server (NTRS)

    Evans, Michael L.

    1998-01-01

    The Gordon Research Conference (GRC) on GRAVITATIONAL EFFECTS ON LIVING SYSTEMS was held at COLBY SAYWER 2 from 7/12/98 thru 7/17/98. The Conference was well-attended with 94 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings.

  13. Active living for rural youth: addressing physical inactivity in rural communities.

    PubMed

    Yousefian, Anush; Ziller, Erika; Swartz, Jon; Hartley, David

    2009-01-01

    Rural youth are at greater risk than urban youth for obesity and physical inactivity. Active living research incorporates an ecological approach to promoting physical activity (PA) by recognizing that individual behavior, social environments, physical environments, and policies contribute to behavior change. Active living research and interventions have been limited primarily to urban settings. Because rural communities have unique environmental features and sociocultural characteristics, this project combines insights from current active living models with more focused consideration of the physical and social realities of rural areas. In this study, we report on our efforts to develop, test, and refine a conceptual model describing the interaction between the individual and the environment as it enhances or thwarts active living in rural communities. Our findings revealed a host of relevant "predisposing" and "enabling" factors, including sociodemographic, environmental, policy, and programmatic elements, that extend across the four domains of active living--transportation, recreation, occupation, and household. A one-size approach to PA promotion will not fit the needs of rural youth. Given the unique challenges that rural communities face, efforts to combat childhood obesity must consider rural residents a priority population. More research, interventions, and evaluations on ways to promote rural PA are needed.

  14. Living on Active Volcanoes - The Island of Hawai'i

    USGS Publications Warehouse

    Heliker, Christina; Stauffer, Peter H.; Hendley, James W.

    1997-01-01

    People on the Island of Hawai'i face many hazards that come with living on or near active volcanoes. These include lava flows, explosive eruptions, volcanic smog, damaging earthquakes, and tsunamis (giant seawaves). As the population of the island grows, the task of reducing the risk from volcano hazards becomes increasingly difficult. To help protect lives and property, U.S. Geological Survey (USGS) scientists at the Hawaiian Volcano Observatory closely monitor and study Hawai'i's volcanoes and issue timely warnings of hazardous activity.

  15. 1998 Gordon Research Conference on Gravitational Effects on Living Systems

    NASA Technical Reports Server (NTRS)

    Evans, Michael L.

    1998-01-01

    The Gordon Research Conference (GRC) on GRAVITATIONAL EFFECTS ON LIVING SYSTEMS was held at COLBY SAYWER 2 from 7/12/98 thru 7/17/98. The Conference was well-attended with 94 participants. The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S. and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. A copy of the formal schedule and speaker program and the poster program is included. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field.

  16. A Study of Activities of Daily Living and Employment in Adults with Autism Spectrum Disorders in Taiwan

    ERIC Educational Resources Information Center

    Lin, Ling-Yi; Yu, Shu-Ning; Yu, Ya-Tsu

    2012-01-01

    Research on daily living activities and employment levels of adults with autism spectrum disorders (ASD) in Taiwan is limited. The aims of the study were to investigate outcomes related to functional independence and employment among people with ASD in Taiwan. We investigated the daily living activities and the employment status of 81 adults (age…

  17. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells

    NASA Astrophysics Data System (ADS)

    Kiyonaka, Shigeki; Kubota, Ryou; Michibata, Yukiko; Sakakura, Masayoshi; Takahashi, Hideo; Numata, Tomohiro; Inoue, Ryuji; Yuzaki, Michisuke; Hamachi, Itaru

    2016-10-01

    The controlled activation of proteins in living cells is an important goal in protein-design research, but to introduce an artificial activation switch into membrane proteins through rational design is a significant challenge because of the structural and functional complexity of such proteins. Here we report the allosteric activation of two types of membrane-bound neurotransmitter receptors, the ion-channel type and the G-protein-coupled glutamate receptors, using coordination chemistry in living cells. The high programmability of coordination chemistry enabled two His mutations, which act as an artificial allosteric site, to be semirationally incorporated in the vicinity of the ligand-binding pockets. Binding of Pd(2,2‧-bipyridine) at the allosteric site enabled the active conformations of the glutamate receptors to be stabilized. Using this approach, we were able to activate selectively a mutant glutamate receptor in live neurons, which initiated a subsequent signal-transduction pathway.

  18. Imaging of influenza virus sialidase activity in living cells.

    PubMed

    Kurebayashi, Yuuki; Takahashi, Tadanobu; Otsubo, Tadamune; Ikeda, Kiyoshi; Takahashi, Shunsaku; Takano, Maiko; Agarikuchi, Takashi; Sato, Tsubasa; Matsuda, Yukino; Minami, Akira; Kanazawa, Hiroaki; Uchida, Yuko; Saito, Takehiko; Kawaoka, Yoshihiro; Yamada, Toshihiro; Kawamori, Fumihiko; Thomson, Robin; von Itzstein, Mark; Suzuki, Takashi

    2014-05-02

    Influenza virus is rich in variation and mutations. It would be very convenient for virus detection and isolation to histochemically detect viral infection regardless of variation and mutations. Here, we established a histochemical imaging assay for influenza virus sialidase activity in living cells by using a new fluorescent sialidase substrate, 2-(benzothiazol-2-yl)-4-bromophenyl 5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosidonic acid (BTP3-Neu5Ac). The BTP3-Neu5Ac assay histochemically visualized influenza virus-infected cells regardless of viral hosts and subtypes. Influenza virus neuraminidase-expressed cells, viral focus formation, and virus-infected locations in mice lung tissues were easily, rapidly, and sensitively detected by the BTP3-Neu5Ac assay. Histochemical visualization with the BTP3-Neu5Ac assay is extremely useful for detection of influenza viruses without the need for fixation or a specific antibody. This novel assay should greatly improve the efficiency of detection, titration, and isolation of influenza viruses and might contribute to research on viral sialidase.

  19. Physical Activity in the Lives of Hong Kong Chinese Children

    ERIC Educational Resources Information Center

    Ha, Amy S.; Macdonald, Doune; Pang, Bonnie O. H.

    2010-01-01

    To understand the physical activity culture in the lives of Hong Kong Chinese children and their parents, 48 young people between the ages 9 and 16 and their parents, with different socio-economic backgrounds and geographical locations, were interviewed for this study. By applying Confucianism and postcolonialism, this study aimed to investigate…

  20. Fostering Activities of Daily Living by Intact Nursing Home Residents

    ERIC Educational Resources Information Center

    Blair, Charles E.; Glaister, Judy; Brown, Alston; Phillips, Carolyn

    2007-01-01

    We assessed effectiveness of four education programs in providing nursing assistants with ability to produce a therapeutic milieu supportive of intact residents' activities of daily living, positive self-esteem and mood: (1) a combination of Orem's Systems of Nursing Care and Skinner's Applied Behavioral Analysis, (2) Applied Behavioral Analysis,…

  1. Enhancing the Lives of Nursing Home Patients through Reading Activities.

    ERIC Educational Resources Information Center

    Lovelace, Terry

    This study investigated the use of reading activities in the enhancement of the lives of nursing-home patients. A special reading group was led by a reading specialist in weekly sessions. Patients voluntarily attended the one-hour sessions and read short selections supplied by the reading specialist. Patients ranged in age from 54 to 91. The…

  2. Determinants of physical activity among Somali women living in Maine.

    PubMed

    Devlin, John T; Dhalac, Deqa; Suldan, Asha A; Jacobs, Ana; Guled, Khadija; Bankole, Kolawole A

    2012-04-01

    Somali women living in the US are at increased risk for chronic health conditions due to changes in lifestyle following immigration. Numerous barriers to physical activity have been reported in this population. Behavioral theory may inform the design of successful health interventions. We explored in focus groups the behavioral determinants of physical activity (theory of planned behavior, self-efficacy) among Somali women (N = 30). We found that most (two-thirds) subjects were sedentary, although women who had lived in the US for 10 years or longer were more likely to be active. Somali women recognize the health threat of physical inactivity, including high rates of obesity. Moral norms appear to be the major barrier to physical activity, due to prohibitions against exercising in public or in Western-style clothing. Taking moral norms into consideration should allow for the design of culturally-appropriate exercise programs that can address a major health threat in this vulnerable population.

  3. Exploring socioecological correlates of active living in retirement village residents.

    PubMed

    Nathan, Andrea; Wood, Lisa; Giles-Corti, Billie

    2014-01-01

    This study explored individual, social, and built environmental attributes in and outside of the retirement village setting and associations with various active living outcomes including objectively measured physical activity, specific walking behaviors, and social participation. Residents in Perth, Australia (N = 323), were surveyed on environmental perceptions of the village and surrounding neighborhood, self-reported physical activity, and demographic characteristics and wore accelerometers. Managers (N = 32) were surveyed on village characteristics, and objective neighborhood measures were generated in a Geographic Information System (GIS). Results indicated that built- and social-environmental attributes within and outside of retirement villages were associated with active living among residents; however, salient attributes varied depending on the specific outcome considered. Findings suggest that locating villages close to destinations is important for walking and that locating them close to previous and familiar neighborhoods is important for social participation. Further understanding and consideration into retirement village designs that promote both walking and social participation are needed.

  4. A Review of Living Collections with Special Emphasis on Sustainability and Its Impact on Research Across Multiple Disciplines

    PubMed Central

    2017-01-01

    Formal living collections have unique characteristics that distinguish them from other types of biorepositories. Comprising diverse resources, microbe culture collections, crop and biodiversity plant germplasm collections, and animal germplasm repositories are commonly allied with specific research communities or stakeholder groups. Among living collections, microbial culture collections have very long and unique life histories, with some being older than 100 years. Regulatory, financial, and technical developments have impacted living collections in many ways. International treaty obligations and restrictions on release of genetically modified organisms complicate the activities of living collections. Funding for living collections is a continuing challenge and threatens to create a two-tier system where medically relevant collections are well funded and all other collections are underfunded and hence understaffed. Molecular, genetic, and whole genome sequence analysis of contents of microbes and other living resource collections bring additional value to living collections. PMID:27869477

  5. A Review of Living Collections with Special Emphasis on Sustainability and Its Impact on Research Across Multiple Disciplines.

    PubMed

    McCluskey, Kevin

    2017-02-01

    Formal living collections have unique characteristics that distinguish them from other types of biorepositories. Comprising diverse resources, microbe culture collections, crop and biodiversity plant germplasm collections, and animal germplasm repositories are commonly allied with specific research communities or stakeholder groups. Among living collections, microbial culture collections have very long and unique life histories, with some being older than 100 years. Regulatory, financial, and technical developments have impacted living collections in many ways. International treaty obligations and restrictions on release of genetically modified organisms complicate the activities of living collections. Funding for living collections is a continuing challenge and threatens to create a two-tier system where medically relevant collections are well funded and all other collections are underfunded and hence understaffed. Molecular, genetic, and whole genome sequence analysis of contents of microbes and other living resource collections bring additional value to living collections.

  6. "Live from IPY"--Connecting Students, Teachers and the Public to Polar Research

    NASA Astrophysics Data System (ADS)

    Breen, K.; Warnick, W. K.; Warburton, J.; Fischer, K.; Wiggins, H.

    2007-12-01

    PolarTREC-Teachers and Researchers Exploring and Collaborating is a three-year (2007-2009) teacher professional development program of the Arctic Research Consortium of the U.S. (ARCUS) that pairs K-12 teachers with researchers to improve science education through authentic polar research experiences. Each year of PolarTREC, approximately 15 teachers spend two to six weeks in the Arctic or Antarctic, working closely with researchers investigating a wide range of topics such as sea-ice dynamics, terrestrial ecology, marine biology, atmospheric chemistry, and long-term climate change. PolarTREC is funded by the National Science Foundation. While in the field, teachers and researchers communicate extensively with their colleagues, communities, and hundreds of students of all ages across the globe, using a variety of communication technologies and tools to appeal to broad student and public engagement in polar science. Through the PolarTREC website (www.polartrec.com) teachers connect from the field through the use of online journals and forums, photo galleries, podcasts, and learning resources. "Live from IPY," a key activity of PolarTREC, is a free, interactive, distance-learning experience that virtually transports students and the public to unique and remote polar locations through a live Internet interface. Rather than relying solely on the asynchronous elements of online journals, forums, photo albums, and podcasts, "Live from IPY" allows real-time interaction by adding elements including live voice, video, chat, application sharing, polling, and whiteboards, but requires only telephone and/or Internet access for participants and presenters to connect. "Live from IPY" and the online outreach elements of PolarTREC convey the excitement of polar research experiences to a broad audience far beyond the classrooms of the PolarTREC teachers, allowing anyone to join a global network of scientists, teachers, students, and communities and actively participate in the

  7. AFS dynamics in a short-lived active region

    NASA Astrophysics Data System (ADS)

    Zuccarello, F.; Battiato, V.; Contarino, L.; Romano, P.; Spadaro, D.; Vlahos, L.

    2005-11-01

    In the framework of the study on active region emergence, we report the results obtained from the analysis of the short-lived (7 days) active region NOAA 10407. The data used were acquired during an observational campaign carried out with the THEMIS telescope in IPM mode in July 2003, coordinated with other ground- and space-based instruments (INAF-OACT, DOT, BBSO, MDI/SOHO, EIT/SOHO, TRACE). We determined the morphological and magnetic evolution of NOAA 10407, as well as the velocity fields associated with its magnetic structures. Within the limits imposed by the spatial and temporal resolution of the images analyzed, the first evidence of the active region formation is initially observed in the transition region and lower corona, and later on (i.e. after about 7 h) in the inner layers, as found in a previous analysis concerning a long-lived, recurrent active region. The results also indicate that the AFS formed in the active region shows typical upward motion at the AFS's tops and downward motion at the footpoints. The velocity values relevant to the upward motions decrease over the evolution of the region, similarly to the case of the recurrent active region, while we notice an increasing trend in the downflow velocity during the early phases of the time interval analyzed by THEMIS. On the other hand, the AFS preceding legs show a higher downflow than the following ones, a result in contrast with that found in the long-lived active region. The chromospheric area overhanging the sunspot umbra shows an upward motion of ˜ 2 km s-1, while that above the pores shows a downward motion of ~4 km s-1.

  8. Planning and Conducting Research Activities.

    ERIC Educational Resources Information Center

    Christiansen, Richard L.

    1983-01-01

    Some directions and influences on dental research activities in the near future are discussed. Current challenges include international competition, fellowships, and equipment. Potential research activity includes preventive medicine, epidemiology, chronic illness, the elderly, bioengineering, materials research, nutrition, soft tissue research,…

  9. Muscle metabolic function and free-living physical activity.

    PubMed

    Hunter, Gary R; Larson-Meyer, D Enette; Sirikul, Bovorn; Newcomer, Bradley R

    2006-11-01

    We have previously shown that muscle metabolic function measured during exercise is related to exercise performance and subsequent 1-yr weight gain. Because it is well established that physical activity is important in weight maintenance, we examined muscle function relationships with free-living energy expenditure and physical activity. Subjects were 71 premenopausal black and white women. Muscle metabolism was evaluated by (31)P magnetic resonance spectroscopy during 90-s isometric plantar flexion contractions (45% maximum). Free-living energy expenditure (TEE) was measured using doubly labeled water, activity-related energy expenditure (AEE) was calculated as 0.9 x TEE - sleeping energy expenditure from room calorimetry, and free-living physical activity (ARTE) was calculated by dividing AEE by energy cost of standard physical activities. At the end of exercise, anaerobic glycolytic rate (ANGLY) and muscle concentration of phosphomonoesters (PME) were negatively related to TEE, AEE, and ARTE (P < 0.05). Multiple regression analysis showed that both PME (partial r = -0.29, <0.02) and ANGLY (partial r = -0.24, P < 0.04) were independently related to ARTE. PME, primarily glucose-6-phosphate and fructose-6-phosphate, was significantly related to ratings of perceived exertion (r = 0.21, P < or = 0.05) during a maximal treadmill test. PME was not related to ARTE after inclusion of RPE in the multiple regression model, suggesting that PME may be obtaining its relationship with ARTE through an increased perception of effort during physical activity. In conclusion, physically inactive individuals tend to be more dependent on anaerobic glycolysis during exercise while relying on a glycolytic pathway that may not be functioning optimally.

  10. Active Cellular Mechanics and Information Processing in the Living Cell

    NASA Astrophysics Data System (ADS)

    Rao, M.

    2014-07-01

    I will present our recent work on the organization of signaling molecules on the surface of living cells. Using novel experimental and theoretical approaches we have found that many cell surface receptors are organized as dynamic clusters driven by active currents and stresses generated by the cortical cytoskeleton adjoining the cell surface. We have shown that this organization is optimal for both information processing and computation. In connecting active mechanics in the cell with information processing and computation, we bring together two of the seminal works of Alan Turing.

  11. A Comparison of Activity Levels among Adults with Intellectual Disabilities Living in Family Homes and Out-of-Family Placements

    ERIC Educational Resources Information Center

    Felce, David; Perry, Jonathan; Kerr, Michael

    2011-01-01

    Background: The quality of life of adults with intellectual disabilities living in the family home is an under-researched area. The current study compared indicators of household and community activity between adults living in family homes and those in out-of-family placements. Methods: Four datasets were merged to produce information on the…

  12. Positive Technology for Healthy Living and Active Ageing.

    PubMed

    Riva, Giuseppe; Gaggioli, Andrea; Villani, Daniela; Cipresso, Pietro; Repetto, Claudia; Serino, Silvia; Triberti, Stefano; Brivio, Eleonora; Galimberti, Carlo; Graffigna, Guendalina

    2014-01-01

    Information and communication technologies are widely and rapidly spreading in people's daily lives. But what is the possible role of the mass proliferation of digital devices in supporting healthy living and active ageing? Are they useful in fostering personal growth and individual integration of the elderly, by promoting satisfaction, opportunities for action, and self-expression? Rather, do they enhance automation, impose constraints on personal initiative, and result in compulsive consumption of information? In this chapter, we suggest that possible answers to these questions will be offered by the "Positive Technology" approach, i.e., the scientific and applied approach to using technology so that it improves the quality of our personal experiences through its structuring, augmentation, and/or replacement. First, we suggest that it is possible to use technology to manipulate the quality of experience with the goal of increasing wellness and generating strengths and resilience in individuals, organizations, and society. Then, we classify positive technologies according to their effects on these three features of personal experience - Hedonic: technologies used to induce positive and pleasant experiences; Eudaimonic: technologies used to support individuals in reaching engaging and self-actualizing experiences; Social/Interpersonal: technologies used to support and improve the connectedness between individuals, groups, and organizations. Finally, we discuss the possible role of positive technologies for healthy living and active ageing by presenting different practical applications of this approach.

  13. An overview of Japanese CELSS research activities.

    PubMed

    Nitta, K

    1987-01-01

    Many research activities regarding Controlled Ecological Life Support System (CELSS) have been conducted and continued all over the world since the 1960's and the concept of CELSS is now changing from Science Fiction to Scientific Reality. Development of CELSS technology is inevitable for future long duration stays of human beings in space, for lunar base construction and for manned mars flight programs. CELSS functions can be divided into two categories, Environment Control and Material Recycling. Temperature, humidity, total atmospheric pressure and partial pressure of oxygen and carbon dioxide, necessary for all living things, are to be controlled by the environment control function. This function can be performed by technologies already developed and used as the Environment Control Life Support System (ECLSS) of Space Shuttle and Space Station. As for material recycling, matured technologies have not yet been established for fully satisfying the specific metabolic requirements of each living thing including human beings. Therefore, research activities for establishing CELSS technology should be focused on material recycling technologies using biological systems such as plants and animals and physico-chemical systems, for example, a gas recycling system, a water purifying and recycling system and a waste management system. Based on these considerations, Japanese research activities have been conducted and will be continued under the tentative guideline of CELSS research activities as shown in documents /1/, /2/. The status of the over all activities are discussed in this paper.

  14. An overview of Japanese CELSS research activities

    NASA Astrophysics Data System (ADS)

    Nitta, Keiji

    Many research activities regarding Controlled Ecological Life Support System (CELSS) have been conducted and continued all over the world since the 1960's and the concept of CELSS is now changing from Science Fiction to Scientific Reality. Development of CELSS technology is inevitable for future long duration stays of human beings in space, for lunar base construction and for manned mars flight programs. CELSS functions can be divided into two categories, Environment Control and Material Recycling. Temperature, humidity, total atmospheric pressure and partial pressure of oxygen and carbon dioxide, necessary for all living things, are to be controlled by the environment control function. This function can be performed by technologies already developed and used as the Environment Control Life Support System (ECLSS) of Space Shuttle and Space Station. As for material recycling, matured technologies have not yet been established for fully satisfying the specific metabolic requirements of each living thing including human beings. Therefore, research activities for establishing CELSS technology should be focused on material recycling technologies using biological systems such as plants and animals and physico-chemical systems, for example, a gas recycling system, a water purifying and recycling system and a waste management system. Based on these considerations, Japanese research activities have been conducted and will be continued under the tentative guideline of CELSS research activities as shown in documents /1/,/2/. The status of the over all activities are discussed in this paper.

  15. A fluorescent reporter of caspase activity for live imaging

    PubMed Central

    Bardet, Pierre-Luc; Kolahgar, Golnar; Mynett, Anita; Miguel-Aliaga, Irene; Briscoe, James; Meier, Pascal; Vincent, Jean-Paul

    2008-01-01

    There is a growing interest in the mechanisms that control the apoptosis cascade during development and adult life. To investigate the regulatory events that trigger apoptosis in whole tissues, we have devised a genetically encoded caspase sensor that can be detected in live and fixed tissue by standard confocal microscopy. The sensor comprises two fluorophores, mRFP, monomeric red fluorescent protein (mRFP) and enhanced green fluorescent protein (eGFP), that are linked by an efficient and specific caspase-sensitive site. Upon caspase activation, the sensor is cleaved and eGFP translocates to the nucleus, leaving mRFP at membranes. This is detected before other markers of apoptosis, including anti–cleaved caspase 3 immunoreactivity. Moreover, the sensor does not perturb normal developmental apoptosis and is specific, as cleavage does not occur in Drosophila embryos that are unable to activate the apoptotic cascade. Importantly, dying cells can be recognized in live embryos, thus opening the way for in vivo imaging. As expected from the high conservation of caspases, it is also cleaved in dying cells of chick embryos. It is therefore likely to be generally useful to track the spatiotemporal pattern of caspase activity in a variety of species. PMID:18779587

  16. Living Educational Theory Research as Transformational Continuing Professional Development

    ERIC Educational Resources Information Center

    Whitehead, Jack; Huxtable, Marie

    2013-01-01

    Continuing professional development (CPD) living educational theory offers an approach to CPD that enables educators to enhance their own professional practice and enable them to offer as gifts the knowledge, expertise and talents they develop to extend the knowledge base of the profession. In this paper we briefly introduce living theory research…

  17. Determination of Long-Lived Neutron Activation Products in Reactor Shielding Concrete Samples

    SciTech Connect

    Zagar, Tomaz; Ravnik, Matjaz

    2002-10-15

    The results of activation studies of TRIGA research reactor concrete shielding are given. Samples made of ordinary and barytes concrete were irradiated in the reactor to simulate neutron activation in the shielding concrete. Long-lived neutron-induced gamma-ray-emitting radioactive nuclides were measured in the samples with a high-purity germanium detector. The most active long-lived radioactive nuclides in the ordinary concrete samples were found to be {sup 60}Co and {sup 152}Eu. In the barytes concrete samples, the most active long-lived radioactive nuclides were {sup 60}Co, {sup 133}Ba, and {sup 152}Eu. Activation in the concrete was also calculated using the ORIGEN2 code and compared to experimental results. Simple radioactive nuclide generation and depletion calculation using one-group cross-section libraries provided together with the ORIGEN2 code did not give conservative results. Significant discrepancies were observed for some nuclides. For accurate long-lived radioactive nuclide generation in reactor shielding, material-specific cross-section libraries should be generated and verified by measurement.

  18. Lower Acetylcholinesterase Activity among Children Living with Flower Plantation Workers

    PubMed Central

    Suarez-Lopez, Jose R.; Jacobs, David R.; Himes, John H.; Alexander, Bruce H.; Lazovich, DeAnn; Gunnar, Megan

    2012-01-01

    BACKGROUND Children of workers exposed to pesticides are at risk of secondary pesticide exposure. We evaluated the potential for lower acetylcholinesterase activity in children cohabiting with fresh-cut flower plantation workers, which would be expected from organophosphate and carbamate insecticide exposure. Parental home surveys were performed and acetylcholinesterase activity was measured in 277 children aged 4–9 years in the study of Secondary Exposure to Pesticides among Infants, Children and Adolescents (ESPINA). Participants lived in a rural county in Ecuador with substantial flower plantation activity. RESULTS Mean acetylcholinesterase activity was 3.14 U/ml, standard deviation (SD): 0.49. It was lower by 0.09 U/ml (95% confidence interval (CI) −0.19, −0.001) in children of flower workers (57% of participants) than non-flower workers’ children, after adjustment for gender, age, height-for-age, hemoglobin concentration, income, pesticide use within household lot, pesticide use by contiguous neighbors, examination date and residence distance to nearest flower plantation. Using a 4 level polychotomous acetylcholinesterase activity dependent variable, flower worker cohabitation (vs. not) had odds ratio 3.39 (95% CI 1.19, 9.64) for being <15th percentile compared to the highest tertile. Children cohabitating for ≥5 years (vs. never) had OR of 4.11 (95% CI: 1.17, 14.38) of AChE activity within <15th percentile compared to the highest tertile. CONCLUSIONS Cohabitation with a flower worker was related to lower acetylcholinesterase activity in children. This supports the hypothesis that the amount of take-home pesticides from flower workers suffices to decrease acetylcholinesterase activity, with lower activity associated with longer exposure. PMID:22405996

  19. Nuclear pore ion channel activity in live syncytial nuclei.

    PubMed

    Bustamante, Jose Omar

    2002-05-01

    Nuclear pore complexes (NPCs) are important nanochannels for the control of gene activity and expression. Most of our knowledge of NPC function has been derived from isolated nuclei and permeabilized cells in cell lysates/extracts. Since recent patch-clamp work has challenged the dogma that NPCs are freely permeable to small particles, a preparation of isolated living nuclei in their native liquid environment was sought and found: the syncytial nuclei in the water of the coconut Cocos nucifera. These nuclei have all properties of NPC-mediated macromolecular transport (MMT) and express foreign green fluorescent protein (GFP) plasmids. They display chromatin movement, are created by particle aggregation or by division, can grow by throwing filaments to catch material, etc. This study shows, for the first time, that living NPCs engaged in MMT do not transport physiological ions - a phenomenon that explains observations of nucleocytoplasmic ion gradients. Since coconuts are inexpensive (less than US$1/nut per litre), this robust preparation may contribute to our understanding of NPCs and cell nucleus and to the development of biotechnologies for the production of DNA, RNA and proteins.

  20. CURRENT AND KINETIC HELICITY OF LONG-LIVED ACTIVITY COMPLEXES

    SciTech Connect

    Komm, Rudolf; Gosain, Sanjay

    2015-01-01

    We study long-lived activity complexes and their current helicity at the solar surface and their kinetic helicity below the surface. The current helicity has been determined from synoptic vector magnetograms from the NSO/SOLIS facility, and the kinetic helicity of subsurface flows has been determined with ring-diagram analysis applied to full-disk Dopplergrams from NSO/GONG and SDO/HMI. Current and kinetic helicity of activity complexes follow the hemispheric helicity rule with mainly positive values (78%; 78%, respectively, with a 95% confidence level of 31%) in the southern hemisphere and negative ones (80%; 93%, respectively, with a 95% confidence level of 22% and 14%, respectively) in the northern hemisphere. The locations with the dominant sign of kinetic helicity derived from Global Oscillation Network Group (GONG) and SDO/HMI data are more organized than those of the secondary sign even if they are not part of an activity complex, while locations with the secondary sign are more fragmented. This is the case for both hemispheres even for the northern one where it is not as obvious visually due to the large amount of magnetic activity present as compared to the southern hemisphere. The current helicity shows a similar behavior. The dominant sign of current helicity is the same as that of kinetic helicity for the majority of the activity complexes (83% with a 95% confidence level of 15%). During the 24 Carrington rotations analyzed here, there is at least one longitude in each hemisphere where activity complexes occur repeatedly throughout the epoch. These ''active'' longitudes are identifiable as locations of strong current and kinetic helicity of the same sign.

  1. Real-time transposable element activity in individual live cells

    PubMed Central

    Lee, Gloria; Martini, K. Michael

    2016-01-01

    The excision and reintegration of transposable elements (TEs) restructure their host genomes, generating cellular diversity involved in evolution, development, and the etiology of human diseases. Our current knowledge of TE behavior primarily results from bulk techniques that generate time and cell ensemble averages, but cannot capture cell-to-cell variation or local environmental and temporal variability. We have developed an experimental system based on the bacterial TE IS608 that uses fluorescent reporters to directly observe single TE excision events in individual cells in real time. We find that TE activity depends upon the TE’s orientation in the genome and the amount of transposase protein in the cell. We also find that TE activity is highly variable throughout the lifetime of the cell. Upon entering stationary phase, TE activity increases in cells hereditarily predisposed to TE activity. These direct observations demonstrate that real-time live-cell imaging of evolution at the molecular and individual event level is a powerful tool for the exploration of genome plasticity in stressed cells. PMID:27298350

  2. Influence of Activity Monitor Location and Bout Duration on Free-Living Physical Activity

    ERIC Educational Resources Information Center

    Heil, Daniel P.; Bennett, Gary G.; Bond, Kathleen S.; Webster, Michael D.; Wolin, Kathleen Y.

    2009-01-01

    The purpose of this study was to evaluate the influence of the location (ankle, hip, wrist) where an activity monitor (AM) is worn and of the minimum bout duration (BD) on physical activity (PA) variables during free-living monitoring. Study 1 participants wore AMs at three locations for 1 day while wearing the Intelligent Device for Energy…

  3. Safety and science at sea: connecting science research settings to the classroom through live video

    NASA Astrophysics Data System (ADS)

    Cohen, E.; Peart, L. W.

    2011-12-01

    Many science teachers start the year off with classroom safety topics. Annual repetition helps with mastery of this important and basic knowledge, while helping schools to meet their legal obligations for safe lab science. Although these lessons are necessary, they are often topical, rarely authentic and relatively dull. Interesting connections can, however, be drawn between the importance of safety in science classrooms and the importance of safety in academic laboratories, fieldwork, shipboard research, and commercial research. Teachers can leverage these connections through live video interactions with scientists in the field, thereby creating an authentic learning environment. During the School of Rock 2009, a professional teacher research experience aboard the Integrated Ocean Drilling Program's research vessel JOIDES Resolution, safety and nature-of-science curricula were created to help address this need. By experimenting with various topics and locations on the ship that were accessible and applicable to middle school learning, 43 highly visual "safety signs" and activities were identified and presented "live" by graduate students, teachers, scientists; the ship's mates, doctor and technical staff. Students were exposed to realistic science process skills along with safety content from the world's only riserless, deep-sea drilling research vessel. The once-in-a-lifetime experience caused the students' eyes to brighten behind their safety glasses, especially as they recognized the same eye wash station and safety gear they have to wear and attended a ship's fire and safety drill along side scientists in hard hats and personal floatation devices. This collaborative and replicable live vide approach will connect basic safety content and nature-of-science process skills for a memorable and authentic learning experience for students.

  4. Research Opportunities and Challenges in the Era of Healthy Living Medicine: Unlocking the Potential.

    PubMed

    Phillips, Shane A; Martino, Sharon; Arena, Ross

    2017-01-26

    Non-communicable diseases, such as cardiovascular disease (CVD), obesity, cancer, pulmonary disease, and diabetes are a very high global health concern. The health costs of risk factors for CVD, such as hypertension (HTN), is mounting and are unrelenting. As an example, it is estimated that direct and indirect costs due to HTN amounted to $46.4 billion in 2011 and projections of six-fold increases by 2030; the importance of low-cost nonpharmacological interventions involving collaborative teams of health care professionals is at a critical junction. Certainly, the data supported by research including some clinical trials for healthy living interventions support deploying health education, nutrition, smoking cessation, and physical activity(PA) in preventing CVD risk, such as HTN. Exercise training (ET) for blood pressure (BP) control has been shown to be an effective and integral component of BP management. However, less is known about what optimization of PA/ET modalities with nutrition and lifestyle tracking with modern era technologies will bring to this equation. New research methods may need to consider how to collaborate to collect data in using teams of researchers while interacting with community centers, school systems, and in traditional health care practices. This review will discuss and present what is known about the research that support modern era healthy living medicine and how this data may be integrated in venues that support health lifestyle in the community (i.e. schools and the work place).

  5. Life Events and Interdependent Lives. Implications for Research and Intervention.

    ERIC Educational Resources Information Center

    Pruchno, R. A.; And Others

    1984-01-01

    Argues that a single life event has the capacity to affect not one but several lives. This thesis is related to theories on attachment, roles, and convoys. The concept of life-event webs is introduced to explain complex relations among individuals within networks such as families. (Author/RH)

  6. Randomised controlled trials of physical activity promotion in free living populations: a review.

    PubMed Central

    Hillsdon, M; Thorogood, M; Anstiss, T; Morris, J

    1995-01-01

    OBJECTIVES--To review evidence on the effectiveness of trials of physical activity promotion in healthy, free living adults. To identify the more effective intervention programmes. METHODS--Computerised databases and references were searched. Experts were contacted and asked for information about existing work. INCLUSION CRITERIA--Randomised controlled trials of healthy, free living adult subjects, where exercise behaviour was the dependent variable were included. CONCLUSIONS--Ten trials were identified. The small number of trials limits the strength of any conclusions and highlights the need for more research. No UK based studies were found. Previously sedentary adults can increase activity levels and sustain them. Promotion of these changes requires personal instruction, continued support, and exercise of moderate intensity which does not depend on attendance at a facility. The exercise should be easily included into an existing lifestyle and should be enjoyable. Walking is the exercise most likely to fulfil these criteria. PMID:7499985

  7. How to Identify Success Among Networks That Promote Active Living

    PubMed Central

    Litt, Jill; Varda, Danielle; Reed, Hannah; Retrum, Jessica; Tabak, Rachel; Gustat, Jeanette; Tompkins, Nancy O’Hara

    2017-01-01

    Objectives We evaluated organization- and network-level factors that influence organizations’ perceived success. This is important for managing interorganizational networks, which can mobilize communities to address complex health issues such as physical activity, and for achieving change. Methods In 2011, we used structured interview and network survey data from 22 states in the United States to estimate multilevel random-intercept models to understand organization- and network-level factors that explain perceived network success. Results A total of 53 of 59 “whole networks” met the criteria for inclusion in the analysis (89.8%). Coordinators identified 559 organizations, with 3 to 12 organizations from each network taking the online survey (response rate: 69.7%; range: 33%–100%). Occupying a leadership position (P < .01), the amount of time with the network (P < .05), and support from community leaders (P < .05) emerged as correlates of perceived success. Conclusions Organizations’ perceptions of success can influence decisions about continuing involvement and investment in networks designed to promote environment and policy change for active living. Understanding these factors can help leaders manage complex networks that involve diverse memberships, varied interests, and competing community-level priorities. PMID:26378863

  8. Research and Development. Laboratory Activities.

    ERIC Educational Resources Information Center

    Gallaway, Ann, Ed.

    Research and Development is a laboratory-oriented course that includes the appropriate common essential elements for industrial technology education plus concepts and skills related to research and development. This guide provides teachers of the course with learning activities for secondary students. Introductory materials include an…

  9. Health smart home for elders - a tool for automatic recognition of activities of daily living.

    PubMed

    Le, Xuan Hoa Binh; Di Mascolo, Maria; Gouin, Alexia; Noury, Norbert

    2008-01-01

    Elders live preferently in their own home, but with aging comes the loss of autonomy and associated risks. In order to help them live longer in safe conditions, we need a tool to automatically detect their loss of autonomy by assessing the degree of performance of activities of daily living. This article presents an approach enabling the activities recognition of an elder living alone in a home equipped with noninvasive sensors.

  10. Illuminating the Lived Experiences of Research with Indigenous Communities

    ERIC Educational Resources Information Center

    Burnette, Catherine E.; Sanders, Sara; Butcher, Howard K.; Salois, Emily Matt

    2011-01-01

    The historical exploitation experienced by indigenous people in the United States has left a number of negative legacies, including distrust toward research. This distrust poses a barrier to progress made through culturally sensitive research. Given the complex history of research with indigenous groups, the purpose of this descriptive…

  11. Research on rehabilitation interventions for adults living with HIV: a scoping review.

    PubMed

    Stevens, Marianne E; Nixon, Stephanie A

    2016-06-01

    The aim of this paper is to use a scoping review to investigate the extent, range, and nature of research on rehabilitation interventions for adults living with HIV. Electronic databases (MEDLINE, EMBASE, CINAHL, AMED, and PsychINFO) and reference lists of the included articles were searched. Authors were emailed when possible for unavailable articles. A total of 897 titles and abstracts were retrieved. Thirty-three articles were included. There were 27 different rehabilitation interventions delivered by 18 professions. The studies were completed in four different countries. Most studies were published in 2008. A randomized-controlled trial was the most used method. The nature of the studies was analyzed according to the three-core concepts of the International Classification of Functioning, Disability and Health: 28 studies addressed impairments; six studies addressed activity limitations; and 14 studies addressed participation restrictions. This scoping study advances the knowledge of research on rehabilitation interventions for adults living with HIV. More research on rehabilitation interventions is needed in sub-Saharan Africa and other low-income and middle-income countries to ensure that these individuals are receiving the best possible care. There is a need for the HIV field to recognize the important contribution of rehabilitation toward the HIV care continuum.

  12. Load along the femur shaft during activities of daily living.

    PubMed

    D'Angeli, V; Belvedere, C; Ortolani, M; Giannini, S; Leardini, A

    2013-08-09

    A comprehensive knowledge of the loads applied during activities of daily living to the femur shaft is necessary to the design of direct attachments of relevant prostheses. A motion analysis system was used together with an established protocol with skin markers to estimate the three components of the forces and moments acting on ten equidistant points along the full femur shaft. Twenty healthy young volunteers were analyzed while performing three repetitions of the following tasks: level walking at three different speeds, straight-line and with sudden changes of direction to the right and to the left, stairs ascending and descending, squat, rising from a chair and sitting down. Average load patterns, after normalisation for body weight and height, were calculated over subjects for each point, about the three anatomical axes, and for each motor task. These patterns were found consistent over subjects, but different among the anatomical axes and tasks. In general, the moments were observed limitedly influenced by the progression speed, and higher for more proximal points. The moments were also higher in abd/adduction (8.1% body weight*height on average), nearly three times larger than those in flex/extension (2.6) during stair descending. The largest value over all moments was 164.8 N m, abd/adduction in level walking at high speed. The present results should be of value also for a most suitable level for amputation in transfemoral amputation, for in-vitro mechanical tests and for finite element models of the femur.

  13. Transition in participation in sport and unstructured physical activity for rural living adolescent girls.

    PubMed

    Eime, R M; Payne, W R; Casey, M M; Harvey, J T

    2010-04-01

    Physical activity (PA) is important for lifelong health; however, participation is lower in rural compared with metropolitan areas and declines during adolescence, particularly for girls. It is likely that this decline is related to the number of life transitions that occur during adolescence. This qualitative study examined the views of active rural living girls regarding the factors affecting their sport and PA participation, using the socioecological model. Twenty-seven girls aged 16-17 from four schools participated in semi-structured focus group discussions. Content and thematic analysis was conducted from verbatim transcripts using NVivo. The girls enjoyed involvement in community club sport with friends and they reported living in communities where participation in sport was a major form of social interaction. However, the desire to succeed educationally was a critical factor affecting their participation in sport and PA and influenced their movement from structured club sport to more flexible, but socially isolated individual activities. It is recommended that future longitudinal research should track rural living adolescent females as they complete secondary school, in order to better understand the influence of educational priorities upon sport and PA participation and to identify practical strategies for both schools and community organizations to foster continuing participation throughout this crucial period of life transition.

  14. Breakthrough: NETL's Research Saving Lives with Coronary Stents

    SciTech Connect

    Turner, Paul

    2012-11-26

    NETL's Albany location is world renown for its expertise in materials research. One recent offshoot of this expertise was the assistance in developing a new material for coronary stents. This research led to the development of a stent which now has a 33% global market share and has produced over four hundred sustainable jobs in the United States.

  15. University Research. Touching the Lives of All Americans.

    ERIC Educational Resources Information Center

    National Association of State Universities and Land Grant Colleges, Washington, DC.

    This report discusses the social and economic benefits of university research, arguing that if funding for research programs is reduced, short-term savings could impose long-term costs, depriving Americans of scientific breakthroughs, economic growth, and improvements in international competitiveness. It provides over 100 brief summaries of…

  16. Breakthrough: NETL's Research Saving Lives with Coronary Stents

    ScienceCinema

    Turner, Paul

    2016-07-12

    NETL's Albany location is world renown for its expertise in materials research. One recent offshoot of this expertise was the assistance in developing a new material for coronary stents. This research led to the development of a stent which now has a 33% global market share and has produced over four hundred sustainable jobs in the United States.

  17. Living-Learning Communities and Independent Higher Education. Innovations in Teaching and Learning. Research Brief 4

    ERIC Educational Resources Information Center

    Katz, Philip M.

    2015-01-01

    Living-learning communities combine curricular, co-curricular, and residential components of college life. They are a relatively new variation on the residential education that has been part of the undergraduate experience at America's independent colleges and universities for centuries. Research suggests that living-learning communities have a…

  18. Managing Everyday Ethics in Assisted Living: A Research-Based Case Analysis for the Classroom

    ERIC Educational Resources Information Center

    Messikomer, Carla M.; Cirka, Carol C.

    2008-01-01

    This paper presents a complex, but realistic, picture of the lived experience in assisted living (AL), and provokes thoughtful reflection about the operational and ethical challenges faced in the delivery of care to an increasingly frail population in a typical AL facility. Developed from the findings of a two-year qualitative research project,…

  19. An overview of Japanese CELSS research activities

    NASA Technical Reports Server (NTRS)

    Nitta, Keiji

    1987-01-01

    Development of Controlled Ecological Life Support System (CELSS) technology is inevitable for future long duration stays of human beings in space, for lunar base construction and for manned Mars flight programs. CELSS functions can be divided into 2 categories, Environmental Control and Material Recycling. Temperature, humidity, total atmospheric pressure and partial pressure of oxygen and carbon dioxide, necessary for all living things, are to be controlled by the environment control function. This function can be performed by technologies already developed and used as the Environment Control Life Support System (ECLSS) of Space Shuttle and Space Station. As for material recycling, matured technologies have not yet been established for fully satisfying the specific metabolic requirements of each living thing including human beings. Therefore, research activities for establishing CELSS technology should be focused on material recycling technologies using biological systems such as plants and animals and physico-chemical systems, for example, a gas recycling system, a water purifying and recycling system and a waste management system. Japanese research activities were conducted and will be continued accordingly.

  20. Load along the tibial shaft during activities of daily living.

    PubMed

    D'Angeli, V; Belvedere, C; Ortolani, M; Giannini, S; Leardini, A

    2014-03-21

    External load at the tibia during activities of daily living provides baseline measures for the improvement of the design of the bone-implant interface for relevant internal and external prostheses. A motion analysis system was used together with an established protocol with skin markers to estimate three-dimensional forces and moments acting on ten equidistant points along the tibial shaft. Twenty young and able-bodied volunteers were analysed while performing three repetitions of the following tasks: level walking at three different speeds, in a straight-line and with sudden changes of direction to the right and to the left, stair ascending and descending, squatting, rising from a chair and sitting down. Moment and force patterns were normalised to the percentage of body weight per height and body weight, respectively, and then averaged over all subjects for each point, about the three tibial anatomical axes, and for each task. Load patterns were found to be consistent over subjects, but different among the anatomical axes, tasks and points. Generally, moments were higher in the medio/lateral axis and influenced by walking speed. In all five walking tasks and in ascending stairs with alternating feet, the more proximal the point was the smaller the mean moment was. For the remaining tasks the opposite trend was observed. The overall largest value was observed in the medio/lateral direction at the ankle centre in level walking at high speed (9.1% body weight * height on average), nearly three times larger than that of the anterior/posterior axis (2.9) during level walking with a sidestep turn. The present results should be of value also for in-vitro mechanical tests and finite element models.

  1. Activity of daily living for Morquio A syndrome.

    PubMed

    Yasuda, Eriko; Suzuki, Yasuyuki; Shimada, Tsutomu; Sawamoto, Kazuki; Mackenzie, William G; Theroux, Mary C; Pizarro, Christian; Xie, Li; Miller, Freeman; Rahman, Tariq; Kecskemethy, Heidi H; Nagao, Kyoko; Morlet, Thierry; Shaffer, Thomas H; Chinen, Yasutsugu; Yabe, Hiromasa; Tanaka, Akemi; Shintaku, Haruo; Orii, Kenji E; Orii, Koji O; Mason, Robert W; Montaño, Adriana M; Fukao, Toshiyuki; Orii, Tadao; Tomatsu, Shunji

    2016-06-01

    The aim of this study was to evaluate the activity of daily living (ADL) and surgical interventions in patients with mucopolysaccharidosis IVA (MPS IVA). The factor(s) that affect ADL are age, clinical phenotypes, surgical interventions, therapeutic effect, and body mass index. The ADL questionnaire comprises three domains: "Movement," "Movement with cognition," and "Cognition." Each domain has four subcategories rated on a 5-point scale based on the level of assistance. The questionnaire was collected from 145 healthy controls and 82 patients with MPS IVA. The patient cohort consisted of 63 severe and 17 attenuated phenotypes (2 were undefined); 4 patients treated with hematopoietic stem cell transplantation (HSCT), 33 patients treated with enzyme replacement therapy (ERT) for more than a year, and 45 untreated patients. MPS IVA patients show a decline in ADL scores after 10years of age. Patients with a severe phenotype have a lower ADL score than healthy control subjects, and lower scores than patients with an attenuated phenotype in domains of "Movement" and "Movement with cognition." Patients, who underwent HSCT and were followed up for over 10years, had higher ADL scores and fewer surgical interventions than untreated patients. ADL scores for ERT patients (2.5years follow-up on average) were similar with the-age-matched controls below 10years of age, but declined in older patients. Surgical frequency was higher for severe phenotypic patients than attenuated ones. Surgical frequency for patients treated with ERT was not decreased compared to untreated patients. In conclusion, we have shown the utility of the proposed ADL questionnaire and frequency of surgical interventions in patients with MPS IVA to evaluate the clinical severity and therapeutic efficacy compared with age-matched controls.

  2. Activity of daily living for Morquio A syndrome

    PubMed Central

    Yasuda, Eriko; Suzuki, Yasuyuki; Shimada, Tsutomu; Sawamoto, Kazuki; Mackenzie, William G.; Theroux, Mary C.; Pizarro, Christian; Xie, Li; Miller, Freeman; Rahman, Tariq; Kecskemethy, Heidi H.; Nagao, Kyoko; Morlet, Thierry; Shaffer, Thomas H.; Chinen, Yasutsugu; Yabe, Hiromasa; Tanaka, Akemi; Shintaku, Haruo; Orii, Kenji E.; Orii, Koji O.; Mason, Robert W.; Montaño, Adriana M.; Fukao, Toshiyuki; Orii, Tadao; Tomatsu, Shunji

    2016-01-01

    The aim of this study was to evaluate the activity of daily living (ADL) and surgical interventions in patients with mucopolysaccharidosis IVA (MPS IVA). The factor(s) that affect ADL are age, clinical phenotypes, surgical interventions, therapeutic effect, and body mass index. The ADL questionnaire comprises three domains: “Movement,” “Movement with cognition,” and “Cognition.” Each domain has four subcategories rated on a 5-point scale based on the level of assistance. The questionnaire was collected from 145 healthy controls and 82 patients with MPS IVA. The patient cohort consisted of 63 severe and 17 attenuated phenotypes (2 were undefined); 4 patients treated with hematopoietic stem cell transplantation (HSCT), 33 patients treated with enzyme replacement therapy (ERT) for more than a year, and 45 untreated patients. MPS IVA patients show a decline in ADL scores after 10 years of age. Patients with a severe phenotype have a lower ADL score than healthy control subjects, and lower scores than patients with an attenuated phenotype in domains of “Movement” and “Movement with cognition.” Patients, who underwent HSCT and were followed up for over 10 years, had higher ADL scores and fewer surgical interventions than untreated patients. ADL scores for ERT patients (2.5 years follow-up on average) were similar with the-age-matched controls below 10 years of age, but declined in older patients. Surgical frequency was higher for severe phenotypic patients than attenuated ones. Surgical frequency for patients treated with ERT was not decreased compared to untreated patients. In conclusion, we have shown the utility of the proposed ADL questionnaire and frequency of surgical interventions in patients with MPS IVA to evaluate the clinical severity and therapeutic efficacy compared with age-matched controls. PMID:27161890

  3. Harvard-MIT research program in short-lived radiopharmaceuticals. Final report

    SciTech Connect

    Adelstein, S.J.

    1995-02-01

    The Harvard-MIT Research Program in Short-lived Radiopharmaceuticals was established in 1977 to foster interaction among groups working in radiopharmaceutical chemistry at Harvard Medical School, the Massachusetts Institute of Technology, and the Massachusetts General Hospital. To this was added a group at The Childrens Hospital. From these collaborations and building upon the special strengths of the participating individuals, laboratories and institutions, it was hoped that original approaches would be found for the design of new, clinically useful, radiolabeled compounds. The original thrust of this proposal included: (a) examination of the coordination chemistry of technetium as a basis for rational radiopharmaceutical design, (b) development of an ultrashort-lived radionuclide generator for the diagnosis of congenital heart disease in newborns, (c) synthesis of receptor-site-directed halopharmaceuticals, (d) improved facile labeling of complex molecules with positron-emitting radionuclides. The authors` 1986 proposal was oriented toward organs and disease, emphasizing radiolabeled agents that delineate specific functions and the distribution of receptors in brain, heart, and tumors. In 1989, they further refined their purposes and focused on two major aims: (a) synthesis and utilization of neutral technetium and rhenium complexes of high specific activity, and (b) development of new approaches to the radiolabeling of proteins, peptides, immunoglobulins, and their fragments. In 1992, the authors amended this proposal to concentrate their efforts on biologically active peptides and proteins for targeted radiodiagnosis and therapy.

  4. Impact of odor from industrial hog operations on daily living activities.

    PubMed

    Tajik, M; Muhammad, N; Lowman, A; Thu, K; Wing, S; Grant, G

    2008-01-01

    Intensive industrial animal production systems worldwide require confinement of large numbers of animals in small spaces and concentration of enormous quantities of waste. Industrial hog operations, in particular, have raised public concerns about their adverse impact on public health and sustainable development. Using a community-based participatory research approach and qualitative interviews, we explored people's perception of the impact of odor from these industries on daily living activities as they relate to the beneficial use of property and enjoyment of life. Our research indicates that hog odor limits several leisure time activities and social interactions which could have adverse public health consequences. The results of this study can assist the communities and other stakeholders in public policy development that addresses these concerns.

  5. Research in Review. Children Living with the Nuclear Threat.

    ERIC Educational Resources Information Center

    Reifel, Stuart

    1984-01-01

    Reviews the literature on children and the threat of nuclear war, focusing on four areas: awareness of nuclear weapons, fear of the bomb, influences on personality, and denial of the threat. The research is briefly critiqued, and implications for early childhood are drawn. (RH)

  6. Harvard-MIT research program in short-lived radiopharmaceuticals

    SciTech Connect

    Adelstein, S.J.

    1991-01-01

    This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)

  7. Does Research Count in the Lives of Behavioral Scientists?

    ERIC Educational Resources Information Center

    Wineburg, Samuel S.

    1987-01-01

    This rejoinder reiterates the author's position that the self-fulfilling prophesy phenomenon can not be proved. Unsuccessful efforts to replicate the "Pygmalion" study are presented. Because replication is essential to proofs in behavioral science research, the phenomenon can not be considered valid to behavioral scientists. (VM)

  8. Joining the Game: Living and Learning as an Action Researcher

    ERIC Educational Resources Information Center

    Hughes, Susan

    2016-01-01

    This study reports on graduate students' thoughts and beliefs about utilizing action research as a means of professional development two years after their graduation from a Master of Arts program in Education. Because many school districts now encourage teachers to engage in self-study and to collect data that informs their instruction, the author…

  9. Living the Praxis of Teacher Education through Teacher Research

    ERIC Educational Resources Information Center

    Torres, Myriam N.; Mercado, Maria

    2004-01-01

    The main objective of this self-study is to reflect and document the development of our own praxis by using teacher research in our teacher education courses. By praxis we mean an ongoing interdependent process in which reflection, including theoretical analysis, enlightens action, and in turn the transformed action changes our understanding of…

  10. Teacher Inquiry: Living the Research in Everyday Practice.

    ERIC Educational Resources Information Center

    Clarke, Anthony, Ed.; Erickson, Gaalen, Ed.

    This book includes 22 papers in three parts. After (1) "Teacher Inquiry: A Defining Feature of Professional Practice" (Anthony Clarke and Gaalen Erickson), Part 1, "Enacting Teacher Research in Practice Settings," includes (2) "Writing Matters: Exploring the Relationship between Writing Instruction and Assessment"…

  11. Kameleon Live: A Cloud Based Analysis and Visualization Platform for Space Weather Researchers

    NASA Astrophysics Data System (ADS)

    Colbert, J. A.; Pembroke, A. D.

    2015-12-01

    NASA's Community Coordinated Modeling Center [CCMC] hosts many of the simulations used by the community of space weather researchers and forecasters. In order to increase the speed of scientific discovery and model validation, we have developed Kameleon Live: a new interactive cloud based analysis and visualization engine that enables users to quickly share, validate, and disseminate their findings. Kameleon Live links several specialized software tools into a single operating environment allowing large datasets to be processed by a central computing system, allowing visualizations to be dynamically generated as users interact with the datasets. Together with feedback from end-users, Kameleon Live will help streamline the workflow for space weather researchers and forecasters.

  12. Activation induced morphological changes and integrin αIIbβ3 activity of living platelets.

    PubMed

    Posch, Sandra; Neundlinger, Isabel; Leitner, Michael; Siostrzonek, Peter; Panzer, Simon; Hinterdorfer, Peter; Ebner, Andreas

    2013-04-01

    Platelets are essential in hemostasis. Upon activation they undergo a shape-change accompanied with receptor presentation. Atomic force microscopy (AFM) imaging and single molecule force spectroscopy (SMFS) were used as powerful tools for exploring morphological changes as well as receptor activities of platelets. Imaging time series was accomplished with and without fixation steps at the single platelet level. Hereby the response of mechanical stimulation of the platelet by the AFM cantilever tip was directly observed. We demonstrate that living and fixed platelets develop filopodia after a short activation time followed by their disappearance including cellular bleb formation. Thereafter a second filopodia formation (filopodia extrusion) was observed; those filopodia subsequently disappeared again, and finally platelets detached from the support due to cell death. We determined the influence of mechanical stress on the chronology of morphological changes of platelets and demonstrated shear force induced filopodia formation. Through recordings over several hours, topographical AFM images over the full platelet lifetime - from early activation up to apoptosis - are presented. SMFS measurements on living platelets allowed determining the activation state of the most prominent membrane receptor integrin αIIbβ3 at all different phases of activation. αIIbβ3 was fully activated, independent of the morphological state.

  13. Troubling 'lived experience': a post-structural critique of mental health nursing qualitative research assumptions.

    PubMed

    Grant, A

    2014-08-01

    Qualitative studies in mental health nursing research deploying the 'lived experience' construct are often written on the basis of conventional qualitative inquiry assumptions. These include the presentation of the 'authentic voice' of research participants, related to their 'lived experience' and underpinned by a meta-assumption of the 'metaphysics of presence'. This set of assumptions is critiqued on the basis of contemporary post-structural qualitative scholarship. Implications for mental health nursing qualitative research emerging from this critique are described in relation to illustrative published work, and some benefits and challenges for researchers embracing post-structural sensibilities are outlined.

  14. Measuring Disability: Application of the Rasch Model to Activities of Daily Living (ADL/IADL).

    ERIC Educational Resources Information Center

    Sheehan, T. Joseph; DeChello, Laurie M.; Garcia, Ramon; Fifield, Judith; Rothfield, Naomi; Reisine, Susan

    2001-01-01

    Performed a comparative analysis of Activities of Daily Living (ADL) items administered to 4,430 older adults and Instrumental Activities of Daily Living administered to 605 people with rheumatoid arthritis scoring both with Likert and Rasch measurement models. Findings show the superiority of the Rasch approach over the Likert method. (SLD)

  15. Stigma, activism, and well-being among people living with HIV.

    PubMed

    Earnshaw, Valerie A; Rosenthal, Lisa; Lang, Shawn M

    2016-01-01

    Evidence demonstrates that HIV stigma undermines the psychological and physical health of people living with HIV (PLWH). Yet, PLWH describe engaging in HIV activism to challenge stigma, and research suggests that individuals may benefit from activism. We examine associations between experiences of HIV stigma and HIV activism, and test whether HIV activists benefit from greater well-being than non-activists. Participants include 93 PLWH recruited from drop-in centers, housing programs, and other organizations providing services to PLWH in the Northeastern USA between 2012 and 2013 (mean age = 50 years; 56% Black, 20% White, 18% Other; 61% non-Latino(a), 39% Latino(a); 59% male, 38% female, 3% transgender; 82% heterosexual, 15% sexual minority). Participants completed a cross-sectional written survey. Results of regression analyses suggest that PLWH who experienced greater enacted stigma engaged in greater HIV activism. Anticipated, internalized, and perceived public stigma, however, were unrelated to HIV activism. Moreover, results of a multivariate analysis of variance suggest that HIV activists reported greater social network integration, greater social well-being, greater engagement in active coping with discrimination, and greater meaning in life than non-activists. Yet, HIV activists also reported somewhat greater depressive symptoms than non-activists, suggesting that the association between HIV activism and well-being is complex. By differentiating between HIV stigma mechanisms, the current study provides a more nuanced understanding of which experiences of HIV stigma may be associated with HIV activism. It further suggests that engagement in activism may offer benefits to PLWH, while raising the possibility that activists could experience greater depressive symptoms than non-activists. Given the preliminary nature of this study, future research should continue to examine these complex associations between HIV stigma, activism, and well-being among PLWH

  16. Activities of daily living in children with developmental coordination disorder: dressing, personal hygiene, and eating skills.

    PubMed

    Summers, Janet; Larkin, Dawne; Dewey, Deborah

    2008-04-01

    In order to understand how age, culture, and problems in motor coordination impact the performance of activities of daily living, we used focus groups and in-depth interviews with Australian and Canadian parents to examine activities of daily living of younger (5-7 years of age) and older (8-9 years of age) children with and without DCD. By comparison with their typically developing age group, children with DCD had more difficulty with dressing, personal hygiene, and eating skills. Difficulties with postural control and fine-motor skills were reported to contribute to poorer performance of activities of daily living. As expected, competence in the performance of activities of daily living improved in the older children with and without DCD and there were few differences in the performance of daily living tasks between typical children in Australia and Canada. Overall, the motor difficulties of children with DCD had a significant impact on performance of a wide range of daily activities.

  17. Children's living arrangements following separation and divorce: insights from empirical and clinical research.

    PubMed

    Kelly, Joan B

    2007-03-01

    When parents separate, children typically enter into new living arrangements with each parent in a pattern determined most often by one or both parents or, failing private agreement, as a result of recommendations and decisions by lawyers, therapists, custody evaluators, or family courts. Most of these decisions have been based on cultural traditions and beliefs regarding postseparation parenting plans, visitation guidelines adopted within jurisdictions, unsubstantiated theory, and strongly held personal values and professional opinions, and have resulted since the 1960s in children spending most of their time with one residential parent and limited time with nonresident, or "visiting", parents. A large body of social science and child development research generated over the past three decades has identified factors associated with risk and resiliency of children after divorce. Such research remains largely unknown and untapped by parents and professionals making these crucial decisions about children's living arrangements. This article highlights empirical and clinical research that is relevant to the shape of children's living arrangements after separation, focusing first on what is known about living arrangements following divorce, what factors influence living arrangements for separated and divorced children, children's views about their living arrangements, and living arrangements associated with children's adjustment following divorce. Based on this research, it is argued that traditional visiting patterns and guidelines are, for the majority of children, outdated, unnecessarily rigid, and restrictive, and fail in both the short and long term to address their best interests. Research-based parenting plan models offering multiple options for living arrangements following separation and divorce more appropriately serve children's diverse developmental and psychological needs.

  18. Loneliness in elderly individuals, level of dependence in activities of daily living (ADL) and influential factors.

    PubMed

    Hacihasanoğlu, Rabia; Yildirim, Arzu; Karakurt, Papatya

    2012-01-01

    This study has been carried out to investigate the level of loneliness, determine the level of dependence in the ADL and influential factors in the elderly people. This descriptive, cross-sectional study was conducted in 5 Family Healthcare Centers (FHC) located in central Erzincan, Turkey between March and June 2010. The data of the research was collected using a questionnaire that determined the descriptive and UCLA Loneliness Scale (UCLA-LS). Mean score of the UCLA-LS was determined as 51.59 ± 4.44. It was determined that 2% of the elderly ADL were completely dependent, 14.5% were semi-dependent. Factors such as being old, a widow/divorced, having a lower level of education and/or income, living alone, having a chronic disease, poor self-perceived health, lack of visits by relatives or acquaintances, dissatisfaction with the place of living, and being fully dependent while performing daily activities were determined as factors which increased the level of loneliness. Furthermore, factors such as being old, a female, a widow/divorced, living together with a daughter/son, having a chronic disease and poor self-perceived health were found to be influential in dependency. Elderly people who are alone and dependent in fulfilling their ADL should be monitored more closely.

  19. Effects of an exercise programme with people living with HIV: research in a disadvantaged setting.

    PubMed

    Ley, Clemens; Leach, Lloyd; Barrio, María Rato; Bassett, Susan

    2014-01-01

    This study aimed to analyse the physical health effects of a community based 10-week physical activity programme with people living with HIV. It was developed, implemented and evaluated in a disadvantaged community in South Africa. A pre-post research design was chosen. Major recruitment and adherence challenges resulted in a small sample. Among the 23 participants who took part in both baseline and final testing, compliant participants (n = 12) were compared to non-compliant participants (n = 11). Immunological (CD4, viral load), anthropometric (height, weight, skinfolds and waist to hip ratio), muscular strength (h1RM) and cardiopulmonary fitness (time on treadmill) parameters were measured. The compliant and non-compliant groups were not different at baseline. Muscular strength was the parameter most influenced by compliance with the physical activity programme (F = 4.516, p = 0.047). Weight loss and improvement in cardiopulmonary fitness were restricted by the duration of the programme, compliance and influencing factors (e.g. nutrition, medication). The increase in strength is significant and meaningful in the context, as the participants' goals were to look healthy and strong to avoid HIV related stigma. The improvements in appearance were a motivational factor, especially since the changes were made visible in a short time. Practical implications for health promotion are described. More research contextualised in disadvantaged settings is needed.

  20. Recruiting Older Adults into a Physical Activity Promotion Program: "Active Living Every Day" Offered in a Naturally Occurring Retirement Community

    ERIC Educational Resources Information Center

    Hildebrand, Mary; Neufeld, Peggy

    2009-01-01

    Purpose: This article explores recruitment strategies based on the transtheoretical model (TTM) with older adults living in a naturally occurring retirement community (NORC) to encourage enrollment in a physical activity promotion program, "Active Living Every Day" (ALED). Reasons for participation or nonparticipation are identified. Design and…

  1. Research and design of a new model for P2P live streaming system

    NASA Astrophysics Data System (ADS)

    Li, Ying; Yang, Lijuan; Liu, Haiyan

    2013-07-01

    According to the research and analysis of typical models for P2P (Peer to Peer) live streaming system, we overview and summarize the strengths and weaknesses of existing technologies. This paper proposes a new model for P2P live streaming system, which used a scheme combining unicast and multicast trees, and analysis the strategy of node management. The model combines advantages of easy maintenance of unicast tree and load balancing of multicast tree, and enhances the availability, stability and quality of service for live streaming system.

  2. Connecting Long Term Ecological Research to the Classroom: A Partnership Between ScienceLIVE and Niwot Ridge LTER

    NASA Astrophysics Data System (ADS)

    Hafich, K. A.; Erb, P.; Ray, C.; Williams, M. W.

    2013-12-01

    Graduate students and researchers at Niwot Ridge LTER are working with a newly developed web-based program, ScienceLIVE, to create cutting edge curriculum that utilizes more than 60 years of publicly available climate data and 30 years of hydrologic and ecological data. The recently released Next Generation Science Standards focus on incorporating the scientific practices of developing and using models, analyzing and interpreting data, and obtaining, evaluating and communicating information. Teachers in Colorado have expressed difficulty in accessing datasets for classroom use, and lack the relationships and connections to university researchers needed to obtain such datasets. ScienceLIVE (www.science-live.org) serves as a bridge between scientists and the public by offering K-12 students and teachers the ability to interact with active field-science through live research updates, interactive web resources, and the use of lesson plans developed with the scientists, using their actual data. As students work through these exercises, the PIs and their field assistants will directly interact with classrooms via webinars to field questions from students. Evaluation and assessment tools are being developed to monitor the success of ScienceLIVE in the classroom after the initial launch in fall of 2013. The collaboration between researchers and outreach efforts faces challenges of sustainability due to turnover in graduate student and project PI involvement, and lack of training in curriculum development. We believe that creating an accessible platform for public outreach and streamlining researcher involvement will encourage a sustainable education and outreach program for Niwot Ridge LTER.

  3. Microrheology, Stress Fluctuations, and Active Behavior of Living Cells

    NASA Astrophysics Data System (ADS)

    Lau, A. W.; Hoffman, B. D.; Davies, A.; Crocker, J. C.; Lubensky, T. C.

    2003-11-01

    We report the first measurements of the intrinsic strain fluctuations of living cells using a recently developed tracer correlation technique along with a theoretical framework for interpreting such data in heterogeneous media with nonthermal driving. The fluctuations' spatial and temporal correlations indicate that the cytoskeleton can be treated as a course-grained continuum with power-law rheology, driven by a spatially random stress tensor field. Combined with recent cell rheology results, our data imply that intracellular stress fluctuations have a nearly 1/ω2 power spectrum, as expected for a continuum with a slowly evolving internal prestress.

  4. Living in a Global Environment. Classroom Activities in Development Education.

    ERIC Educational Resources Information Center

    Fien, John, Ed.

    Forty classroom activities selected from New Internationalist Calendars published between 1984-1989 were collected. Each activity is presented in the form of a short story about a real-life person and a graphic spread of data consisting of maps, tables, photographs, diagrams, text, and student exercises. These activities have been written to…

  5. Evaluation of An Activities of Daily Living Scale for Adolescents and Adults with Developmental Disabilities

    PubMed Central

    Maenner, Matthew J; Smith, Leann E; Hong, Jinkuk; Makuch, Renee; Greenberg, Jan S; Mailick, Marsha R

    2012-01-01

    Background Activity limitations are an important and useful dimension of disability, but there are few validated measures of activity limitations for adolescents and adults with developmental disabilities. Objective/Hypothesis To describe the development of the Waisman Activities of Daily Living (W-ADL) Scale for adolescents and adults with developmental disabilities, and systematically evaluate its measurement properties according to an established set of criteria. Methods The W-ADL was administered among four longitudinally-studied groups of adolescents and adults with developmental disabilities: 406 with autism; 147 with fragile-X syndrome; 169 with Down syndrome, and 292 with intellectual disability of other or unknown origin. The W-ADL contains 17 activities and each is rated on a 3-point scale (0=“does not do at all”, 1=“does with help”, 2=“independent”), and a standard set of criteria were used to evaluate its measurement properties. Results Across the disability groups, Cronbach’s alphas ranged from 0.88 to 0.94, and a single-factor structure was most parsimonious. The W-ADL was reliable over time, with weighted kappas between 0.92 and 0.93. Criterion and construct validity were supported through substantial associations with the Vineland Screener, need for respite services, caregiving burden, and competitive employment. No floor or ceiling effects were present. There were significant group differences in W-ADL scores by maternally-reported level of intellectual disability (mild, moderate, severe, profound). Conclusions The W-ADL exceeded the recommended threshold for each quality criterion the authors evaluated. This freely-available tool is an efficient measure of activities of daily living for surveys and epidemiological research concerning adolescents and adults with developmental disabilities. PMID:23260606

  6. How Children Characterise Living Beings and the Activities in Which They Engage

    ERIC Educational Resources Information Center

    Martínez-Losada, Cristina; García-Barros, Susana; Garrido, María

    2014-01-01

    This study analysed the characteristics that children in the initial stages of schooling attribute to living beings. Interviews were conducted with 138 children aged 3-7 years in a school in the Spanish city of A Coruña, Galicia. Aspects found in pen-and-paper activities dealing with living beings, provided by the teachers (158 in total) at this…

  7. (Instrumental) Activities of Daily Living in Older Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Hilgenkamp, Thessa I. M.; van Wijck, Ruud; Evenhuis, Heleen M.

    2011-01-01

    Daily living skills are important to ageing adults with intellectual disabilities (ID). The purpose of this study was to investigate the level of these skills in older adults with ID and to investigate the influence of gender, age, level of ID and mobility on these skills. Daily living skills were measured with the Barthel Index (for Activities of…

  8. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution.

    PubMed

    Mo, Gary C H; Ross, Brian; Hertel, Fabian; Manna, Premashis; Yang, Xinxing; Greenwald, Eric; Booth, Chris; Plummer, Ashlee M; Tenner, Brian; Chen, Zan; Wang, Yuxiao; Kennedy, Eileen J; Cole, Philip A; Fleming, Karen G; Palmer, Amy; Jimenez, Ralph; Xiao, Jie; Dedecker, Peter; Zhang, Jin

    2017-04-01

    Compartmentalized biochemical activities are essential to all cellular processes, but there is no generalizable method to visualize dynamic protein activities in living cells at a resolution commensurate with cellular compartmentalization. Here, we introduce a new class of fluorescent biosensors that detect biochemical activities in living cells at a resolution up to threefold better than the diffraction limit. These 'FLINC' biosensors use binding-induced changes in protein fluorescence dynamics to translate kinase activities or protein-protein interactions into changes in fluorescence fluctuations, which are quantifiable through stochastic optical fluctuation imaging. A protein kinase A (PKA) biosensor allowed us to resolve minute PKA activity microdomains on the plasma membranes of living cells and to uncover the role of clustered anchoring proteins in organizing these activity microdomains. Together, these findings suggest that biochemical activities of the cell are spatially organized into an activity architecture whose structural and functional characteristics can be revealed by these new biosensors.

  9. Learning to Live: A Manual of Environmental Education Activities.

    ERIC Educational Resources Information Center

    Minnesota State Dept. of Natural Resources, St. Paul. Bureau of Information and Education.

    Contributions from a variety of sources are compiled in this manual to provide both students and teachers with environmental study activities. Several activities are suggested under each of the following topics: Ecology and Esthetics (emphasizing awareness); The Decision-Making Process (resource management problems); A Plea for an Alternative…

  10. Dopa decarboxylase activity of the living human brain

    SciTech Connect

    Gjedde, A.; Reith, J.; Dyve, S.; Leger, G.; Guttman, M.; Diksic, M.; Evans, A.; Kuwabara, H. )

    1991-04-01

    Monoaminergic neurons use dopa decarboxylase to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-({sup 18}F)fluoro-L-dopa and positron emission tomography. We calculated the enzyme activity, relative to its Km, with a kinetic model that yielded the relative rate of conversion of 6-({sup 18}F)fluoro-L-dopa to ({sup 18}F)fluorodopamine. Regional values of relative dopa decarboxylase activity ranged from nil in occipital cortex to 1.9 h-1 in caudate nucleus and putamen, in agreement with values obtained in vitro.

  11. Activities of Daily Living in Mexican American Caregivers: The Key to Continuing Informal Care

    PubMed Central

    Evans, Bronwynne C.; Belyea, Michael J.; Coon, David W.; Ume, Ebere

    2013-01-01

    La familia drives elder care in Mexican–American (MA) families, but nursing home placement can result from day-to-day caregiving demands that increase caregiver difficulty with activities of daily living (ADLs). Using life course perspective, this article describes the initial data wave of 31 MA caregivers from a descriptive, longitudinal, mixed-methods study of 110 MA caregivers and care recipients over 15 months in their caregiving trajectories. Fifteen of 31 caregivers consistently indicated “no help needed” on the Katz ADL, whereas all but one reported “help needed” during semistructured interviews with cultural brokers. In addition to the discrepancy between results on the Katz ADL and interviews, findings include consideration of nursing home placement by moderately acculturated caregivers and minimization of their illnesses by caregivers. Additional methods of MA caregiver assessment may be needed due to the questionable accuracy of the Katz ADL; additional research should explore minimization and acculturation in MA caregivers. PMID:22740307

  12. Activities of daily living and quality of life in Alzheimer disease.

    PubMed

    Opara, J A

    2012-06-12

    Alzheimer's disease is known for placing a significant burden on caregivers, which includes social, psychological, physical or economic aspects. The disease decreases patients' capacity for activities of daily living and quality of life. Information about functional status is useful in the interpretation of the quality of life assessment results. In this paper the most commonly used scales evaluating activities of daily living and quality of life in Alzheimer's disease, either generic or specific, is presented.

  13. Senior Research Connects Students with a Living Laboratory As Part of an Integrated Crop and Livestock System

    NASA Astrophysics Data System (ADS)

    Senturklu, Songul; Landblom, Douglas; Brevik, Eric C.

    2015-04-01

    highest expenses in beef cattle production. Senior research investigating the impact of livestock integration and multi-species cover crop grown within the crop rotation is studying changes in soil attributes resulting from the crop-animal integration by measuring bulk density and in-season soil fertility in the crop rotation. These responses are further contrasted with results from within the crop rotation and responses from perennial native range. Students that become engaged in the research represent a broad cross section of the consuming public and include high school junior and senior students, college undergraduate students that conduct research projects, postdoctoral research scientists engaged in senior level research, agricultural extension educators, and finally, farmer and rancher businessmen. The integrated nature of the research provides a wealth of learning opportunities for these various groups. For the high school students, visits to the living laboratory increase awareness and introduces students to a potential career path in agriculture, natural resource fields, and the many allied vocational fields that support agriculture. When college undergraduate students visit the living laboratory, they seek to address a researchable question or a problem in agriculture, while fulfilling requirements for graduation by conducting a research project. Because postdoctoral students want to be actively engaged in research and advanced learning, they are interested in conducting research in the living laboratory that can be published in peer reviewed journals. Agricultural extension educators, who advise farmers and ranchers, are looking for research results from the living laboratory that can be convey to their constituents. Farmers and ranchers participate in workshop events that give them face-to-face learning opportunities that they can use to effect change in their farm and ranch businesses. Each of these demographic groups are unique in their interest in the

  14. When Worlds Collide: Identity, Culture and the Lived Experiences of Research When "Teaching-Led"

    ERIC Educational Resources Information Center

    Sharp, John G.; Hemmings, Brian; Kay, Russell; Callinan, Carol

    2015-01-01

    This article presents detailed findings from the qualitative or interpretive phase of a mixed-methods case study focusing on the professional identities and lived experiences of research among six lecturers working in different capacities across the field of education in a "teaching-led" higher education institution. Building upon the…

  15. Clean Coal Program Research Activities

    SciTech Connect

    Larry Baxter; Eric Eddings; Thomas Fletcher; Kerry Kelly; JoAnn Lighty; Ronald Pugmire; Adel Sarofim; Geoffrey Silcox; Phillip Smith; Jeremy Thornock; Jost Wendt; Kevin Whitty

    2009-03-31

    Although remarkable progress has been made in developing technologies for the clean and efficient utilization of coal, the biggest challenge in the utilization of coal is still the protection of the environment. Specifically, electric utilities face increasingly stringent restriction on the emissions of NO{sub x} and SO{sub x}, new mercury emission standards, and mounting pressure for the mitigation of CO{sub 2} emissions, an environmental challenge that is greater than any they have previously faced. The Utah Clean Coal Program addressed issues related to innovations for existing power plants including retrofit technologies for carbon capture and sequestration (CCS) or green field plants with CCS. The Program focused on the following areas: simulation, mercury control, oxycoal combustion, gasification, sequestration, chemical looping combustion, materials investigations and student research experiences. The goal of this program was to begin to integrate the experimental and simulation activities and to partner with NETL researchers to integrate the Program's results with those at NETL, using simulation as the vehicle for integration and innovation. The investigators also committed to training students in coal utilization technology tuned to the environmental constraints that we face in the future; to this end the Program supported approximately 12 graduate students toward the completion of their graduate degree in addition to numerous undergraduate students. With the increased importance of coal for energy independence, training of graduate and undergraduate students in the development of new technologies is critical.

  16. Activities of daily living and manual hand dexterity in persons with idiopathic parkinson disease

    PubMed Central

    Choi, Yoo-Im; Song, Chiang-Soon; Chun, Byung-Yoon

    2017-01-01

    [Purpose] The purpose of this study was to evaluate the relationship between daily activities and manual dexterity in persons with Parkinson disease. [Subjects and Methods] The study participants were 25 patients with idiopathic Parkinson disease. This study used two clinical tools, the box-and-block test and Schwab and England Activities of Daily Living scale, to investigate the relationship between manual dexterity and Schwab and England Activities of Daily Living score. [Results] A positive correlation was observed between the Schwab and England Activities of Daily Living and the box-and-block test scores on the more and less affected sides. Moreover, the Schwab and England Activities of Daily Living score had a greater correlation with the box-and-block test score on the less affected side than that on the more affected side. [Conclusion] Manual dexterity and activities of daily living showed a positive correlation in individuals with Parkinson disease. The results of this study suggest that manual dexterity is an important factor for predicting physical performance in daily living in persons with Parkinson disease. PMID:28356630

  17. Activities of daily living and manual hand dexterity in persons with idiopathic parkinson disease.

    PubMed

    Choi, Yoo-Im; Song, Chiang-Soon; Chun, Byung-Yoon

    2017-03-01

    [Purpose] The purpose of this study was to evaluate the relationship between daily activities and manual dexterity in persons with Parkinson disease. [Subjects and Methods] The study participants were 25 patients with idiopathic Parkinson disease. This study used two clinical tools, the box-and-block test and Schwab and England Activities of Daily Living scale, to investigate the relationship between manual dexterity and Schwab and England Activities of Daily Living score. [Results] A positive correlation was observed between the Schwab and England Activities of Daily Living and the box-and-block test scores on the more and less affected sides. Moreover, the Schwab and England Activities of Daily Living score had a greater correlation with the box-and-block test score on the less affected side than that on the more affected side. [Conclusion] Manual dexterity and activities of daily living showed a positive correlation in individuals with Parkinson disease. The results of this study suggest that manual dexterity is an important factor for predicting physical performance in daily living in persons with Parkinson disease.

  18. Effects of mirror therapy combined with motor tasks on upper extremity function and activities daily living of stroke patients

    PubMed Central

    Kim, Kyunghoon; Lee, Sukmin; Kim, Donghoon; Lee, Kyoungbo; Kim, Youlim

    2016-01-01

    [Purpose] The objective of this study was to investigate the effects of mirror therapy combined with exercise tasks on the function of the upper limbs and activities of daily living. [Subjects and Methods] Twenty-five stroke patients who were receiving physical therapy at K Hospital in Gyeonggi-do, South Korea, were classified into a mirror therapy group (n=12) and a conventional therapy group (n=13). The therapies were applied for 30 minutes per day, five times per week, for a total of four weeks. Upper limb function was measured with the Action Research Arm test, the Fugl-Meyer Assessment, and the Box and Block test, and activities of daily living were measured with the Functional Independence Measure. A paired test was performed to compare the intragroup differences between before training and after four weeks of therapy, and an independent t-test was performed to compare the differences between the two groups before and after four weeks of therapy. [Results] In the intragroup comparison, both groups showed significant differences between measurements taken before and after four weeks of therapy. In the intergroup comparison, the mirror therapy group showed significant improvements compared with the conventional therapy group, both in upper limb function and activities of daily living. [Conclusion] The findings of this study demonstrated that mirror therapy is more effective than conventional therapy for the training of stroke patients to improve their upper limb function and activities of daily living. PMID:27065534

  19. School Physical Education, Extracurricular Sports, and Lifelong Active Living

    ERIC Educational Resources Information Center

    Bocarro, Jason; Kanters, Michael A.; Casper, Jonathan; Forrester, Scott

    2008-01-01

    The purpose of this article is to examine the role of school-based extracurricular initiatives in facilitating immediate and long-term positive impact on physical activity, healthy behavior, and obesity in children. A critique of the role of various sports-related initiatives that have been developed to address the obesity epidemic currently…

  20. Matching software practitioner needs to researcher activities

    NASA Technical Reports Server (NTRS)

    Feather, M. S.; Menzies, T.; Connelly, J. R.

    2003-01-01

    We present an approach to matching software practitioners' needs to software researchers' activities. It uses an accepted taxonomical software classfication scheme as intermediary, in terms of which practitioners express needs, and researchers express activities.

  1. Measuring Physical Activity in Children and Youth Living with Intellectual Disabilities: A Systematic Review

    ERIC Educational Resources Information Center

    Hinckson, Erica Aneke; Curtis, Amy

    2013-01-01

    Accurate assessment of physical activity is necessary in determining levels of physical activity in children living with intellectual disability (ID) and assessing effectiveness of intervention programmes. A systematic review of measures of physical activity in children with ID was undertaken using the PRISMA guidelines. MEDLINE-PubMed, Scopus,…

  2. Energy Expended by Adults with and without Intellectual Disabilities during Activities of Daily Living

    ERIC Educational Resources Information Center

    Lante, Kerrie; Reece, John; Walkley, Jeff

    2010-01-01

    The aims of this study were to (1) determine the energy expenditure of adults with and without intellectual disabilities during common activities of daily living (ADL), (2) use these values to evaluate the accuracy of equivalent activity values reported in the Compendium of Physical Activities (CPA), and (3) identify ADL that may confer a health…

  3. "Reality surgery"--a research ethics perspective on the live broadcast of surgical procedures.

    PubMed

    Williams, Judson B; Mathews, Robin; D'Amico, Thomas A

    2011-01-01

    In recent years, the live broadcasting of medical and surgical procedures has gained worldwide popularity. While the practice has appropriately been met with concerns for patient safety and privacy, many physicians tout the merits of real time viewing as a form of investigation, accelerating the process leading to adoption or abolition of newer techniques or technologies. This view introduces a new series of ethical considerations that need to be addressed. As such, this article considers, from a research ethics perspective, the use of live surgical procedure broadcast for investigative purposes.

  4. “Reality Surgery” — A Research Ethics Perspective on the Live Broadcast of Surgical Procedures

    PubMed Central

    Williams, Judson B.; Mathews, Robin; D'Amico, Thomas A.

    2013-01-01

    In recent years, the live broadcasting of medical and surgical procedures has gained worldwide popularity. While the practice has appropriately been met with concerns for patient safety and privacy, many physicians tout the merits of real time viewing as a form of investigation, accelerating the process leading to adoption or abolition of newer techniques or technologies. This view introduces a new series of ethical considerations that need to be addressed. As such, this article considers, from a research ethics perspective, the use of live surgical procedure broadcast for investigative purposes. PMID:21292217

  5. The Promise of Wisconsin's 1999 Comprehensive Planning Law: Land-Use Policy Reforms to Support Active Living.

    PubMed

    Schilling, Joseph; Keyes, Sheila D

    2008-06-01

    Weaving together the disciplines of planning and policy change with the emerging research of active living, this article explores the competing interests and underlying political forces behind the design and passage of Wisconsin's Comprehensive Planning Law of 1999. While Wisconsin's law remains a work in progress, it illustrates the contemporary policy battles over land use and smart growth and the resurgence of the property-rights movement. It further highlights the influence of smart-growth coalitions and policy networks on planning reform. The authors suggest that planning practitioners and active-living proponents can adapt and transfer these policy lessons from Wisconsin to address the complex relationships of the built environment, physical activity, and the nation's current obesity problem through state and local planning reforms.

  6. Understanding the health impacts of urbanization in China: A living laboratory for urban biogeochemistry research

    NASA Astrophysics Data System (ADS)

    Zhu, Y. G.

    2015-12-01

    China has the largest population in the world, and by 2011, more than 50% of its population are now living in cities. This ongoing societal change has profound impacts on environmental quality and population health. In addition to intensive discharges of waste, urbanization is not only changing the land use and land cover, but also inducing fundamental changes in biogeochemical processes. Unlike biogeochemistry in non-urban environment, the biological component of urban biogeochemistry is dominated by direct human activities, such as air pollution derived from transport, wastewater treatment, garbage disposal and increase in impervious surface etc. Managing urban biogeochemistry will include source control over waste discharge, eco-infrastructure (such as green space and eco-drainage), resource recovery from urban waste stream, and integration with peri-urban ecosystem, particularly with food production system. The overall goal of managing urban biogeochemistry is for human health and wellbeing, which is a global challenge. In this paper, the current status of urban biogeochemistry research in China will be briefly reviewed, and then it will focus on nutrient recycling and waste management, as these are the major driving forces of environmental quality changes in urban areas. This paper will take a holistic view on waste management, covering urban metabolism analysis, technological innovation and integration for resource recovery from urban waste stream, and risk management related to waste recycling and recovery.

  7. Lively Earthquake Activity in North-Eastern Greenland

    NASA Astrophysics Data System (ADS)

    Larsen, Tine B.; Dahl-Jensen, Trine; Voss, Peter H.

    2016-04-01

    The seismograph at the Danish military outpost, Station Nord (NOR) in North East Greenland, records many regional/local earthquakes every day. Most of these events originate at the Arctic plate boundary between the Eurasian and the North American plates. The plate boundary has a particularly active segment approximately 200 km from the seismograph. Additionally we find a seismically very active region 20-30 km from NOR on the Kronprins Christian Land peninsula. The BB seismograph at NOR was installed in 2002 and later upgraded with real-time telemetry as part of the GLISN-project. Since late 2013 data from NOR have been included in routine processing at GEUS. Phase readings on some of the older data, primarily 2002-2003, have been carried out previously in connection with other projects. As a result, phase readings for more than 6000 local events, recorded exclusively at NOR, were found in the GEUS data base. During the years 2004 to 2007 four locations were occupied by temporary BB seismographs on the North coast of Greenland as part of the Law of the Sea preparatory work. Data from these stations have not previously been analyzed for local and regional events. In this study we combine the recordings from NOR with phase readings from the temporary seismographs in Northern Greenland. The local events on Kronprins Christian Land range in magnitude from less than 2 to a 4.8 event widely recorded in the region and felt by the personnel at Station Nord on August 30, 2005. Station Nord is located in the seismically most active region of Greenland.

  8. Examination of Children's Recess Physical Activity Patterns Using the Activities for Daily Living-Playground Participation (ADL-PP) Instrument

    ERIC Educational Resources Information Center

    Stellino, Megan Babkes; Sinclair, Christina

    2014-01-01

    Thorough assessment of children's physical activity is essential to efficacious interventions to reduce childhood obesity prevalence. The purpose of this study was to examine children's recess physical activity (RPA) patterns of behavior using the Activities of Daily Living-Playground Participation (ADL-PP: Watkinson et al., 2001) instrument.…

  9. Relating practitioner needs to research activities

    NASA Technical Reports Server (NTRS)

    Feather, M. S.; Menzies, T.; Connelly, J. R.

    2003-01-01

    We present an approach to matching needs (practioner requirements) to solutions (researcher activities). A taxonomical classification scheme acts as intermediary between needs and activities. Expert practitioners exprss their needs in terms of this taxonomy. Researchers express their activities in the same terms. A decision support tool is used to assist in the combination and study of their expressions of needs and activities.

  10. Activation of right fronto-temporal cortex characterizes the 'living' category in semantic processing.

    PubMed

    Leube, D T; Erb, M; Grodd, W; Bartels, M; Kircher, T T

    2001-12-01

    It is a vital ability for humans to distinguish between living and non-living objects. Whether the semantic features of these two classes of objects are represented in distinct brain areas, is unknown. In our study, words belonging to the categories 'living' and 'non-living' were presented visually to twelve right-handed volunteers, while brain activation was measured with event-related fMRI. Subjects had to judge whether the item belonged to one of these categories. Common areas of activation (P<0.05, corrected) during processing of both categories include the inferior occipital gyri bilaterally (BA 17/18), left inferior frontal gyrus (BA 44/45) and left inferior parietal lobe (BA 40). During processing of 'living' minus 'non-living' items, signal changes (P<0.05, corrected) were present in the the right inferior frontal (BA 47), middle temporal (BA 21) and fusiform gyrus (BA 19). Our results are in line with findings from patients with a deficit in semantic processing of living things, who specifically suffer from right hemispheric lesions.

  11. Active invasion of bacteria into living fungal cells.

    PubMed

    Moebius, Nadine; Üzüm, Zerrin; Dijksterhuis, Jan; Lackner, Gerald; Hertweck, Christian

    2014-09-02

    The rice seedling blight fungus Rhizopus microsporus and its endosymbiont Burkholderia rhizoxinica form an unusual, highly specific alliance to produce the highly potent antimitotic phytotoxin rhizoxin. Yet, it has remained a riddle how bacteria invade the fungal cells. Genome mining for potential symbiosis factors and functional analyses revealed that a type 2 secretion system (T2SS) of the bacterial endosymbiont is required for the formation of the endosymbiosis. Comparative proteome analyses show that the T2SS releases chitinolytic enzymes (chitinase, chitosanase) and chitin-binding proteins. The genes responsible for chitinolytic proteins and T2SS components are highly expressed during infection. Through targeted gene knock-outs, sporulation assays and microscopic investigations we found that chitinase is essential for bacteria to enter hyphae. Unprecedented snapshots of the traceless bacterial intrusion were obtained using cryo-electron microscopy. Beyond unveiling the pivotal role of chitinolytic enzymes in the active invasion of a fungus by bacteria, these findings grant unprecedented insight into the fungal cell wall penetration and symbiosis formation.

  12. Active invasion of bacteria into living fungal cells

    PubMed Central

    Moebius, Nadine; Üzüm, Zerrin; Dijksterhuis, Jan; Lackner, Gerald; Hertweck, Christian

    2014-01-01

    The rice seedling blight fungus Rhizopus microsporus and its endosymbiont Burkholderia rhizoxinica form an unusual, highly specific alliance to produce the highly potent antimitotic phytotoxin rhizoxin. Yet, it has remained a riddle how bacteria invade the fungal cells. Genome mining for potential symbiosis factors and functional analyses revealed that a type 2 secretion system (T2SS) of the bacterial endosymbiont is required for the formation of the endosymbiosis. Comparative proteome analyses show that the T2SS releases chitinolytic enzymes (chitinase, chitosanase) and chitin-binding proteins. The genes responsible for chitinolytic proteins and T2SS components are highly expressed during infection. Through targeted gene knock-outs, sporulation assays and microscopic investigations we found that chitinase is essential for bacteria to enter hyphae. Unprecedented snapshots of the traceless bacterial intrusion were obtained using cryo-electron microscopy. Beyond unveiling the pivotal role of chitinolytic enzymes in the active invasion of a fungus by bacteria, these findings grant unprecedented insight into the fungal cell wall penetration and symbiosis formation. DOI: http://dx.doi.org/10.7554/eLife.03007.001 PMID:25182414

  13. Nano-engineered living bacterial motors for active microfluidic mixing.

    PubMed

    Al-Fandi, M; Jaradat, M A K; Fandi, K; Beech, J P; Tegenfeldt, J O; Yih, T C

    2010-09-01

    Active micromixers with rotating elements are attractive microfluidic actuators in many applications because of their mixing ability at a short distance. However, miniaturising the impeller design poses technical challenges including the fabrication and driving means. As a possible solution inspired by macro magnetic bar-stirrers, this study proposes the use of tethered, rotating bacteria as mixing elements. A tethered cell is a genetically engineered, harmless Escherichia coli (E. coli) attached to a surface by a single, shortened flagellum. The tethered flagellum acts as a pivot around which the entire cell body smoothly rotates. Videomicroscopy, image analysis and computational fluid dynamics (CFD) are utilised to demonstrate a proof-of-concept for the micro mixing process. Flow visualisation experiments show that a approximately 3 microm long tethered E. coli rotating at approximately 240 rpm can circulate a 1 microm polystyrene bead in the adjacent area at an average speed of nearly 4 microm/s. The Peclet (Peb) number for the stirred bead is evaluated to approximately 4. CFD simulations show that the rotary motion of a tethered E. coli rotating at 240 rpm can generate fluid velocities, up to 37 microm/s bordering the cell envelop. Based on these simulations, the Strouhal number (St) is calculated to about 2. This hybrid bio-inorganic micromxer could be used as a local, disposable mixer.

  14. OCLC Research: 2012 Activity Report

    ERIC Educational Resources Information Center

    OCLC Online Computer Library Center, Inc., 2013

    2013-01-01

    The mission of the Online Computer Library Center (OCLC) Research is to expand knowledge that advances OCLC's public purposes of furthering access to the world's information and reducing library costs. OCLC Research is dedicated to three roles: (1)To act as a community resource for shared research and development (R&D); (2) To provide advanced…

  15. SALSA : SAving Lives Staying Active to Promote Physical Activity and Healthy Eating.

    PubMed

    Lee, Rebecca E; Mama, Scherezade K; Medina, Ashley; Orlando Edwards, Raul; McNeill, Lorna

    2011-01-01

    Physical inactivity, poor dietary habits, and obesity are vexing problems among minorities. SAving Lives, Staying Active (SALSA) was an 8-week randomized controlled crossover design, pilot study to promote regular physical activity (PA) and fruit and vegetable (FV) consumption as a means to preventing weight gain among women of color. Participants completed measures of demographics, PA, and dietary habits. Women (N = 50; M = 42 years) who participated were overweight (MBMI = 29.7 kg/m(2); Mbody fat = 38.5%) and reported low levels of leisure time PA (M = 10.7 MET-min/wk) and FV consumption (M = 4.2 servings/day). All were randomized to a four-week (1) semiweekly Latin dance group or (2) internet-based dietary education group. All participants reported a significant increase in weekly leisure time PA from baseline (M = 10.7 MET-min/wk) to follow up (M = 34.0 MET-min/wk, P < .001), and FV consumption increased over time by group (P = .02). Data suggest that Latin dance interventions to improve PA and web-based interventions to improve dietary habits show promise for improving health among women of color.

  16. Accountability and pediatric physician-researchers: are theoretical models compatible with Canadian lived experience?

    PubMed Central

    2011-01-01

    Physician-researchers are bound by professional obligations stemming from both the role of the physician and the role of the researcher. Currently, the dominant models for understanding the relationship between physician-researchers' clinical duties and research duties fit into three categories: the similarity position, the difference position and the middle ground. The law may be said to offer a fourth "model" that is independent from these three categories. These models frame the expectations placed upon physician-researchers by colleagues, regulators, patients and research participants. This paper examines the extent to which the data from semi-structured interviews with 30 physician-researchers at three major pediatric hospitals in Canada reflect these traditional models. It seeks to determine the extent to which existing models align with the described lived experience of the pediatric physician-researchers interviewed. Ultimately, we find that although some physician-researchers make references to something like the weak version of the similarity position, the pediatric-researchers interviewed in this study did not describe their dual roles in a way that tightly mirrors any of the existing theoretical frameworks. We thus conclude that either physician-researchers are in need of better training regarding the nature of the accountability relationships that flow from their dual roles or that models setting out these roles and relationships must be altered to better reflect what we can reasonably expect of physician-researchers in a real-world environment. PMID:21974866

  17. Physical Education and Physically Active Lives: A Lifelong Approach to Curriculum Development

    ERIC Educational Resources Information Center

    Penney, Dawn; Jess, Mike

    2004-01-01

    This paper focuses upon the relationship between physical education and interests in enabling more people to establish and maintain "active and healthy lives" from a curriculum development perspective. Twin and inter-linked concepts of "lifelong learning" and "lifelong physical activity" are presented as a conceptual…

  18. Semantic Support Environment for Research Activity

    ERIC Educational Resources Information Center

    Ismail, Maizatul Akmar; Yaacob, Mashkuri; Kareem, Sameem Abdul

    2008-01-01

    Scholarly activities are a collection of academic related activities such as research, teaching and consultation work which result in research outputs such as journals, theses and articles in proceedings. The output will then be disseminated to researchers all over the world by means of the WWW. The four pillars of this scholarship i.e. discovery,…

  19. 38 CFR 1.488 - Research activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Research activities. 1... PROVISIONS Disclosures Without Patient Consent § 1.488 Research activities. Subject to the provisions of 38 U... disclosed for the purpose of conducting scientific research. (a) Information in individually...

  20. Recreating communities to support active living: a new role for social marketing.

    PubMed

    Maibach, Edward W

    2003-01-01

    The lack of routine physical activity has become an all too pervasive health threat in the United States. Social marketing can be used directly to promote increased physical activity among people who have access to active living options (e.g., safe and convenient sidewalks or bike paths). A second, albeit indirect, use of social marketing to promote physical activity--and the focus of this article--involves promoting behaviors that influence the built environment for the purpose of increasing people's access to active living options. This use of social marketing involves changing the behavior of consumers, developers, distribution channels (e.g., real estate agents) and policy makers. The approach offers public health and other organizations a disciplined, consumer-focused means of mobilizing their available resources in a manner that maximizes the odds of creating active living communities. These means include understanding the competition, understanding target markets, creating mutually beneficial exchanges, segmenting markets and targeting them based on anticipated return. This article identifies specific opportunities for applying the social marketing approach to create active living communities, and identifies opportunities at the state and national level that will enhance the effectiveness of local efforts.

  1. A smartphone-driven methodology for estimating physical activities and energy expenditure in free living conditions.

    PubMed

    Guidoux, Romain; Duclos, Martine; Fleury, Gérard; Lacomme, Philippe; Lamaudière, Nicolas; Manenq, Pierre-Henri; Paris, Ludivine; Ren, Libo; Rousset, Sylvie

    2014-12-01

    This paper introduces a function dedicated to the estimation of total energy expenditure (TEE) of daily activities based on data from accelerometers integrated into smartphones. The use of mass-market sensors such as accelerometers offers a promising solution for the general public due to the growing smartphone market over the last decade. The TEE estimation function quality was evaluated using data from intensive numerical experiments based, first, on 12 volunteers equipped with a smartphone and two research sensors (Armband and Actiheart) in controlled conditions (CC) and, then, on 30 other volunteers in free-living conditions (FLC). The TEE given by these two sensors in both conditions and estimated from the metabolic equivalent tasks (MET) in CC served as references during the creation and evaluation of the function. The TEE mean gap in absolute value between the function and the three references was 7.0%, 16.4% and 2.7% in CC, and 17.0% and 23.7% according to Armband and Actiheart, respectively, in FLC. This is the first step in the definition of a new feedback mechanism that promotes self-management and daily-efficiency evaluation of physical activity as part of an information system dedicated to the prevention of chronic diseases.

  2. The power of clinical nursing research: engage clinicians, improve patients' lives, and forge a professional legacy.

    PubMed

    Gawlinski, Anna

    2008-07-01

    Sparked by the Institute of Medicine's report titled Crossing the Quality Chasm, research-based decision making has been emphasized for improving care. Patients should receive care that is based on the best available scientific knowledge, and care should not vary from clinician to clinician or from place to place. Implementing research-based practices at the bedside is a complex endeavor. It is all too easy to discover that clinically important research findings are either not known by practitioners or not being used in actual practice. Efforts to instill and sustain research-based practices improve significantly when staff nurses are involved with the research from the start. Institutions that are effective in involving clinicians have built a foundation of infrastructures that enable processes for engaging clinicians to take place. What distinguishes effective from ineffective hospital nursing research and evidence-based practice programs is the presence of structures whereby processes can occur that (1) unleash the creativity of staff by securing their involvement early, (2) educate staff by involving them, (3) create internal expertise for research and evidence-based practice, and (4) ensure that patients experience principled implementation of research-based practices to improve their lives. This article describes infrastructures that can ensure and sustain research-based practices while unleashing the talent and creativity of clinicians as they question practice and ponder the merits of current research. Fostering participation in such clinical inquiry will summon professional growth, influence the lives of patients, and help each nurse develop a unique personal professional legacy.

  3. Ambient Information Systems to Support the Elderly in Carrying Out Their Activities of Daily Living

    NASA Astrophysics Data System (ADS)

    García-Vázquez, Juan Pablo; Rodríguez, Marcela D.

    As they age, older adult's present losses in their functional capabilities which cause them can't continue performing their activities of daily living (ADL) independently at home. We propose Ambient Information Systems (AIS) as appropriate pervasive devices to promote their independent living. Therefore our aim is to determine the utility and usability of AIS to support the independent life of older adults by helping them to perform their activities. In this paper we present preliminary results of a case study that we carried out for understanding the problems and needs that older adults face in doing some of their activities of daily living. In particular, we present results regarding the elderly problems to adhere to their medication prescription. Based on these results we propose AIS to support older adults to medicate. Finally, we present the design attributes incorporated into this AIS, which were identified from the design taxonomies of AIS reported in the literature.

  4. Nurturing transdisciplinary research - lessons from live experiments in prioritising and supporting novel risk science (Invited)

    NASA Astrophysics Data System (ADS)

    Rees, J.; Armstrong, C.; Barclay, J.; Moores, A.; Whitaker, D.

    2013-12-01

    The benefits of specialization over the last 150 years have meant that science has evolved within several distinct disciplines, such as physical, social or environmental. These have generated their own cultures, languages, agendas, institutions, measures of success and cohorts of suitably branded scientists. However, we increasingly see that society and the environment are exposed to many complex, interdependent and rapidly changing risks - not only from natural hazards, but also those associated with fast expanding and ageing populations, highly interconnected and interdependent economies, rapid climate change, and increasingly limited resources. Risks derived from such interacting drivers commonly generate non-linear effects or repercussions and future risks may be very different to those of today; significantly, they span many traditional science disciplines. We thus need to have a fresh look at transdisciplinary risk science, bring in novel ideas and new blood. But what are the best practical ways of sowing the seeds and fertilizing such approaches? The presentation describes novel practical steps to achieve this, all related to building and resourcing transdisciplinary research which incorporates natural hazard science within the UK over the last 5 years. These comprise instruments to prioritise science gaps and provide funding for transdisciplinary research by a) Academic research funders - the Research Councils UK (RCUK) Risk Research Network and current research programmes; b) Government and non-governmental research funders - the Living with Environmental Change Initiative, and the UK Flooding and coastal erosion risk management research strategy - and the UK Collaborative for Development Science sponsored Disasters Research Group; and c) Business funding - through integrated risk modelling for the insurance industry. Whilst young, all these initiatives are healthy and seek to build a portfolio of small scale initiatives that will breed success and develop

  5. Associations among social capital, parenting for active lifestyles, and youth physical activity in rural families living in upstate New York.

    PubMed

    Davison, Kirsten K; Nishi, Akihiro; Kranz, Sibylle; Wyckoff, Lynae; May, John J; Earle-Richardson, Giulia B; Strogatz, David S; Jenkins, Paul L

    2012-10-01

    While emerging research supports a positive relationship between social capital and youth physical activity (PA), few studies have examined possible mechanisms explaining this relationship and no studies have focused on rural youth. In this study, we examined parents' support of children's PA as an intermediary factor linking social capital and youth PA in a largely rural cross sectional sample of American children aged 6- to 19-years and their parents/guardians (N=767 families) living in upstate New York. Parents completed a self-administered survey assessing demographic factors, perceived social capital, support for children's PA, and children's PA including time spent outdoors and days per week of sufficient PA. Structural equation modeling was used to test the hypothesis that higher social capital is linked with higher parental support for PA and, in turn, higher PA in children. Analyses were conducted separately for younger (6-12 years) and older (13-19 years) children and controlled for demographic factors (child age, household education, participation in a food assistance program) and perceived neighborhood safety. Anticipated relationships among social capital, parents' activity-related support, and children's PA were identified for older, but not younger children. Findings suggest that parent support for children's PA is one possible mechanism linking social capital and youth PA and the parents of adolescents may rely more heavily on cues from their social environment to shape their approaches to supporting their children's PA than parents of younger children.

  6. Do government brochures affect physical activity cognition? A pilot study of Canada's physical activity guide to healthy active living.

    PubMed

    Kliman, Aviva M; Rhodes, Ryan

    2008-08-01

    Health Canada has published national physical activity (PA) guidelines, which are included in their 26-page Physical Activity Guide to Healthy Active Living (CPAG). To date, the use of CPAG as a motivational instrument for PA promotion has not been evaluated. The purpose of this study was to determine whether reading CPAG 1) increased motivational antecedents to engage in regular PA, and 2) increased regular PA intention and behaviour over 1 month. Participants included 130 randomly sampled Canadian adults (18 years or older) who were randomly mailed pack ages consisting of either 1) a questionnaire and a copy of CPAG, or 2) a questionnaire. Questionnaire items pertained to participants' sociodemographics, previous PA behaviours (Godin Leisure-Time Questionnaire) and PA motivation (theory of planned behaviour). Participants were then sent a follow-up questionnaire pertaining to their PA behaviours throughout the previous month. Results revealed significant interactions between the guide condition and previous activity status on instrumental behavioural beliefs about strength activities and subjective norms about endurance activities (p < 0.05), but all other factors were not significantly different. It was concluded that among previously inactive people, receiving this guide may change some informational/motivational constructs, but key motivational antecedents (affective attitude, perceived behavioural control) and outcomes (intention, behaviour) seem unaffected.

  7. Ex utero: live human fetal research and the films of Davenport Hooker.

    PubMed

    Wilson, Emily K

    2014-01-01

    Between 1932 and 1963 University of Pittsburgh anatomist Davenport Hooker, Ph.D., performed and filmed noninvasive studies of reflexive movement on more than 150 surgically aborted human fetuses. The resulting imagery and information would contribute substantially to new visual and biomedical conceptions of fetuses as baby-like, autonomous human entities that emerged in the 1960s and 1970s. Hooker's methods, though broadly conforming to contemporary research practices and views of fetuses, would not have been feasible later. But while Hooker and the 1930s medical and general public viewed live fetuses as acceptable materials for nontherapeutic research, they also shared a regard for fetuses as developing humans with some degree of social value. Hooker's research and the various reactions to his work demonstrate the varied and changing perspectives on fetuses and fetal experimentation, and the influence those views can have on biomedical research.

  8. Sexuality and intimacy among people living with serious mental illnesses: Factors contributing to sexual activity

    PubMed Central

    Bonfils, Kelsey A.; Firmin, Ruth L.; Salyers, Michelle P.; Wright, Eric R.

    2015-01-01

    Objective Limited research has focused on sexuality for those diagnosed with a severe mental illness. We aimed to extend existing work by exploring relationships between mastery (perception of control of one's life and future), sexual self-esteem (perceptions of one's capacity to engage in healthy sexual behavior), sexual attitudes (permissive ideas about sexuality), and perceived importance of relationships/sexuality and number of sexual partners. Methods A secondary analysis of survey data from adult participants living with a severe mental illness (N=401) in the Indiana Mental Health Services and HIV-Risk Study (Perry & Wright, 2006) was conducted. Analysis of covariance (controlling for marital status) compared those with zero partners, one partner, or multiple partners over the past three months on the dependent variables of mastery, sexual self-esteem, sexual attitudes, and perceived importance. Results Participants with more permissive attitudes, greater perceived importance, and higher mastery were more likely to be sexually active with multiple partners. Self-esteem did not differentiate groups. Conclusions and Implications for Practice Given the key role of sexual satisfaction in quality of life and the high rates of sexual risk behavior in this population, it is important that clinicians systematically assess mastery, perceived importance, and attitudes about sexuality when working with consumers diagnosed with a severe mental illness. Individually tailoring existing interventions based on consumers' levels of mastery, related to self-efficacy for implementing changes in life, could improve long-term outcomes for these programs. Future research should examine other constructs that may account for more variance in sexual activity, such as perceptions of risk, intentions for sexual safety, or romantic relationship functioning. PMID:25664756

  9. Multiplanar Knee Laxity and Perceived Function During Activities of Daily Living and Sport

    PubMed Central

    Taylor, Jeffrey B.; Wang, Hsin-Min; Schmitz, Randy J.; Rhea, Christopher K.; Ross, Scott E.; Shultz, Sandra J.

    2015-01-01

    Context Greater knee-joint laxity may lead to a higher risk of knee injury, yet it is unknown whether results of self-reported outcome measures are associated with distinct knee-laxity profiles. Objective To identify the extent to which multiplanar knee laxity is associated with patient-reported outcomes of knee function in healthy individuals during activities of daily living and sport. Design Descriptive laboratory study. Setting University research laboratory. Patients or Other Participants Forty healthy individuals (20 men, 20 women; age = 18–31 years). Main Outcome Measure(s) All participants were given the Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL) and Sports Activities Scale (KOS-SAS) and subsequently measured for knee laxity in the sagittal, frontal, and transverse planes. Separate backward stepwise regression analyses were performed to determine the extent to which multiplanar knee-laxity values predicted KOS-ADL and KOS-SAS scores within each sex. Results Women had higher magnitudes of anterior, posterior (POSTLAX), varus (VARLAX), valgus (VALLAX), and internal-rotation laxity than men and trended toward greater external rotation (ERLAX) laxity. Greater POSTLAX, less VALLAX, and greater VARLAX was associated with lower KOS-ADL scores (KOS-ADL = −4.8 [POSTLAX], + 3.3 [VALLAX] − 2.2 [VARLAX] + 100.4, R2 = 0.74, P < .001) and greater POSTLAX and less VALLAX was associated with lower KOS-SAS scores (KOS-SAS = −8.2 [POSTLAX], + 3.6 [VALLAX] + 96.4, R2 = 0.67, P < .001) in women. In men, greater POSTLAX and less ERLAX was associated with lower KOS-SAS scores (KOS-ADL = −4.7 [POSTLAX], + 0.9 [ERLAX] + 96.4, R2 = 0.49, P < .001). Conclusions The combination of POSTLAX with less relative VALLAX (women) or less relative ERLAX (men) was a strong predictor of KOS scores, suggesting that a self-reported outcome measure may be beneficial as part of a preparticipation screening battery to identify those with perceived functional deficits

  10. An inducible transgene reports activation of macrophages in live zebrafish larvae.

    PubMed

    Sanderson, Leslie E; Chien, An-Tzu; Astin, Jonathan W; Crosier, Kathryn E; Crosier, Philip S; Hall, Christopher J

    2015-11-01

    Macrophages are the most functionally heterogenous cells of the hematopoietic system. Given many diseases are underpinned by inappropriate macrophage activation, macrophages have emerged as a therapeutic target to treat disease. A thorough understanding of what controls macrophage activation will likely reveal new pathways that can be manipulated for therapeutic benefit. Live imaging fluorescent macrophages within transgenic zebrafish larvae has provided a valuable window to investigate macrophage behavior in vivo. Here we describe the first transgenic zebrafish line that reports macrophage activation, as evidenced by induced expression of an immunoresponsive gene 1(irg1):EGFP transgene. When combined with existing reporter lines that constitutively mark macrophages, we reveal this unique transgenic line can be used to live image macrophage activation in response to the bacterial endotoxin lipopolysaccharide and xenografted human cancer cells. We anticipate the Tg(irg1:EGFP) line will provide a valuable tool to explore macrophage activation and plasticity in the context of different disease models.

  11. Managing everyday ethics in assisted living: a research-based case analysis for the classroom.

    PubMed

    Messikomer, Carla M; Cirka, Carol C

    2008-01-01

    This paper presents a complex, but realistic, picture of the lived experience in assisted living (AL), and provokes thoughtful reflection about the operational and ethical challenges faced in the delivery of care to an increasingly frail population in a typical AL facility. Developed from the findings of a two-year qualitative research project, the case represents a composite of selected data collected at five AL facilities that participated in the study. Students will participate in individual and small group exercises that challenge them to identify everyday ethical concerns in AL, and to suggest ways that management can address these issues. The case is suitable for cross-disciplinary use, and can be effectively applied in the fields of management, health care administration, sociology, gerontology, social work, and nursing, either on the graduate or undergraduate level. It is especially well suited to courses that incorporate the topics of long-term care, senior housing, or ethics.

  12. The use of animals in live-tissue trauma training and military medical research.

    PubMed

    Martinic, Gary

    2011-09-21

    Uncontrolled hemorrhage is the most common preventable cause of death for soldiers wounded in combat. In live-tissue trauma training (LTTT), animals (mostly goats and pigs) are used to train physicians and paramedical personnel in how to treat severe traumatic injuries, including severe blood loss. Military personnel insist that such realistic training is necessary and has to date saved countless lives of soldiers. Animal rights groups, however, argue that the practice is inhumane and should be replaced with alternative methods. In this essay, the author explains how and why animals are used for LTTT and in military medical research (MMR), as well as why he feels that the continued use of animals for LTTT and MMR is justified. The author hopes to encourage wider discussion of this topic within the scientific, defense and animal welfare circles, leading to further refinements in the welfare and protection of animals used for these important, though often controversial, purposes.

  13. Enhancing labour force participation for people living with HIV: a multi-perspective summary of the research evidence.

    PubMed

    Worthington, Catherine; O'Brien, Kelly; Zack, Elisse; McKee, Eileen; Oliver, Brent

    2012-01-01

    Labour force participation has been identified as a critical social and health issue facing people living with HIV/AIDS (PHAs). We conducted a scoping study (a form of literature synthesis that summarizes research findings, research activity, and identifies literature strengths and gaps) on labour force participation for PHAs, guided by a community advisory committee. We summarized information from 243 peer-reviewed articles and 42 reports from the grey literature, and synthesized the evidence into a preliminary conceptual framework with five components: (1) the meaning of work, (2) key factors (barriers and facilitators) influencing labour force participation, (3) factors affecting vulnerable populations, (4) strategies and supports for returning to or sustaining work, and (5) outcomes (benefits and risks) of labour force participation for individuals and employers. The framework supports the development of labour force initiatives requiring collaborative efforts in multiple domains (health, employment, community) by PHAs, rehabilitation professionals, employers, insurers, and policy makers.

  14. Activities of daily living, depression, and quality of life in Parkinson's disease.

    PubMed

    Lawrence, Blake J; Gasson, Natalie; Kane, Robert; Bucks, Romola S; Loftus, Andrea M

    2014-01-01

    This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson's disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson's Disease Questionnaire-39 (PDQ-39), and Unified Parkinson's Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HR-QOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD.

  15. ICT services for active ageing and independent living: identification and assessment.

    PubMed

    Christophorou, Christophoros; Kleanthous, Styliani; Georgiadis, Dimosthenis; Cereghetti, Donato M; Andreou, Panayiotis; Wings, Cindy; Christodoulou, Eleni; Samaras, George

    2016-09-01

    Based on the demographic changes and the rapid increase of older population in Europe, major challenges are expected to rise, both in the economy as well as the society, whether the dominant care model for supporting elderly in living independently at home continues to rely on informal and formal caregivers' assistance. To respond to the above challenges, assistive technologies are called to develop Information and Communication Technology (ICT) services for supporting seniors to remain active and independent, for as long as possible, in their chosen home environment. The work described in this Letter is based on the Miraculous-Life project and it emphasises the identification and assessment of a set of services that an ICT system for Ageing Well should support, in an actual end-users setting. The outcome of this work may inform fellow researchers and other projects in the area of Ageing Well in: (i) understanding which ICT services can be the most valuable for end-users' Quality of Life, (ii) prioritising the development of related ICT services and (iii) facilitating better recourse allocation in order to reduce any risks associated to implementation failures of these services within their respective projects. A final trial phase is planned, aiming to validate the Miraculous Life prototype longitudinally in a naturalistic environment with a larger sample size. During this trial, it will be investigated if perceived usefulness, satisfaction and motivation could be predicted by sociodemographic variables and personality.

  16. Transition to Kindergarten Activity the Lived Experiences of Teachers, Parents and Children

    ERIC Educational Resources Information Center

    Latte, Ave M.

    2012-01-01

    Problem: Transitioning into kindergarten marks an important time in the lives of young children and their families. While many families and teachers participate in transition events little is known about the ways that transition activities actually inform and support key stakeholders. The purpose of this study was to describe district transition…

  17. Evaluation of Instrumental Activities of Daily Living in Greek Patients with Advanced Cancer

    ERIC Educational Resources Information Center

    Mystakidou, Kyriaki; Parpa, Efi; Tsilika, Eleni; Panagiotoua, Irene; Roumeliotou, Anna; Symeonidi, Matina; Galanos, Antonis; Kouvaris, Ioannis

    2013-01-01

    Translation of the instrumental activities of daily living (IADL) was carried out and its psychometric properties were assessed in a Greek sample of patients with advanced cancer. The scale was translated with the forward-backward procedure into the Greek language. It was initially administered to 136 advanced cancer patients. To assess…

  18. Ready, Steady, Action: What Enables Young People to Perceive Themselves as Active Agents in Their Lives?

    ERIC Educational Resources Information Center

    Sharp, Russell

    2014-01-01

    Government and educational priorities place importance on young people of secondary school age being active, having their voices heard, and participating in their community. This paper explores an understanding of the role of agency in young people's lives and how the concept is developing. Young people who perceive themselves as having agency may…

  19. Strategies of Daily Living Rehabilitative Activities for Post Stroke Patients at Minia University Hospital

    ERIC Educational Resources Information Center

    Zaky, Hend Elham Mohamed; EL-Lateef Mohammad, Zienab Abd; EL-Labban, Abdou Saad Taha; Ahmed, Gahen

    2015-01-01

    Background: Stroke is a leading cause of disability. Rehabilitation aims to hasten and maximize recovery from stroke by treating the disabilities caused by the stroke. Therefore, the aim of this study determine the post stroke patients' knowledge and practices in relation to disease and activities of daily living before the implementation of…

  20. Fluorescence-Activated Cell Sorting of Live Versus Dead Bacterial Cells and Spores

    NASA Technical Reports Server (NTRS)

    Bernardini, James N.; LaDuc, Myron T.; Diamond, Rochelle; Verceles, Josh

    2012-01-01

    This innovation is a coupled fluorescence-activated cell sorting (FACS) and fluorescent staining technology for purifying (removing cells from sampling matrices), separating (based on size, density, morphology, and live versus dead), and concentrating cells (spores, prokaryotic, eukaryotic) from an environmental sample.

  1. Need for Assistance in the Activities of Daily Living. Disability Statistics Abstract, Number 18.

    ERIC Educational Resources Information Center

    Kennedy, Jae; LaPlante, Mitchell P.; Kaye, H. Stephen

    This abstract summarizes recent statistics on those needing assistance in Activities of Daily Living (ADLs), along with participation rates for various proposed benefit programs, based on an analysis of the 1990-91 Survey of Income and Program Participation. Analysis indicates: (1) an estimated 1.9 percent of the population has difficulty…

  2. Targeted Research and Technology Within NASA's Living With a Star Program

    NASA Technical Reports Server (NTRS)

    Antiochos, Spiro; Baker, Kile; Bellaire, Paul; Blake, Bern; Crowley, Geoff; Eddy, Jack; Goodrich, Charles; Gopalswamy, Nat; Gosling, Jack; Hesse, Michael

    2004-01-01

    Targeted Research & Technology (TR&T) NASA's Living With a Star (LWS) initiative is a systematic, goal-oriented research program targeting those aspects of the Sun-Earth system that affect society. The Targeted Research and Technology (TR&T) component of LWS provides the theory, modeling, and data analysis necessary to enable an integrated, system-wide picture of Sun-Earth connection science with societal relevance. Recognizing the central and essential role that TR&T would have for the success of the LWS initiative, the LWS Science Architecture Team (SAT) recommended that a Science Definition Team (SDT), with the same status as a flight mission definition team, be formed to design and coordinate a TR&T program having prioritized goals and objectives that focused on practical societal benefits. This report details the SDT recommendations for the TR&T program.

  3. 38 CFR 1.488 - Research activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Research activities. 1... PROVISIONS Disclosures Without Patient Consent § 1.488 Research activities. Subject to the provisions of 38 U... paragraphs, patient medical record information covered by §§ 1.460 through 1.499 of this part may...

  4. 38 CFR 1.488 - Research activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Research activities. 1... PROVISIONS Disclosures Without Patient Consent § 1.488 Research activities. Subject to the provisions of 38 U... paragraphs, patient medical record information covered by §§ 1.460 through 1.499 of this part may...

  5. 38 CFR 1.488 - Research activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Research activities. 1... PROVISIONS Disclosures Without Patient Consent § 1.488 Research activities. Subject to the provisions of 38 U... paragraphs, patient medical record information covered by §§ 1.460 through 1.499 of this part may...

  6. 38 CFR 1.488 - Research activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Research activities. 1... PROVISIONS Disclosures Without Patient Consent § 1.488 Research activities. Subject to the provisions of 38 U... paragraphs, patient medical record information covered by §§ 1.460 through 1.499 of this part may...

  7. Living Clusters and Crystals from Low-Density Suspensions of Active Colloids

    NASA Astrophysics Data System (ADS)

    Mognetti, B. M.; Šarić, A.; Angioletti-Uberti, S.; Cacciuto, A.; Valeriani, C.; Frenkel, D.

    2013-12-01

    Recent studies aimed at investigating artificial analogs of bacterial colonies have shown that low-density suspensions of self-propelled particles confined in two dimensions can assemble into finite aggregates that merge and split, but have a typical size that remains constant (living clusters). In this Letter, we address the problem of the formation of living clusters and crystals of active particles in three dimensions. We study two systems: self-propelled particles interacting via a generic attractive potential and colloids that can move toward each other as a result of active agents (e.g., by molecular motors). In both cases, fluidlike “living” clusters form. We explain this general feature in terms of the balance between active forces and regression to thermodynamic equilibrium. This balance can be quantified in terms of a dimensionless number that allows us to collapse the observed clustering behavior onto a universal curve. We also discuss how active motion affects the kinetics of crystal formation.

  8. Supervised classification of Activities of Daily Living in Health Smart Homes using SVM.

    PubMed

    Fleury, Anthony; Noury, Norbert; Vacher, Michel

    2009-01-01

    By 2050, about a third of the French population will be over 65. To face this modification of the population, the current studies of our laboratory focus on the monitoring of elderly people at home. This aims at detect, as early as possible, a loss of autonomy by objectivizing criterions such as the international ADL or the French AGGIR scales implementing automatic classification of the different Activities of Daily Living. A Health Smart Home is used to achieve this goal. This flat includes different sensors. The data from the various sensors were used to classify each temporal frame into one of the activities of daily living that has been previously learnt (seven activities: hygiene, toilets, eating, resting, sleeping, communication and dressing/undressing). This is done using Support Vector Machines. We performed an experimentation with 13 young and healthy subjects to learn the model of activities and then we tested the classification algorithm (cross-validation) on real data.

  9. 42 CFR 2.52 - Research activities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Research activities. 2.52 Section 2.52 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.52 Research... research if the program director makes a determination that the recipient of the patient...

  10. 42 CFR 2.52 - Research activities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Research activities. 2.52 Section 2.52 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.52 Research... research if the program director makes a determination that the recipient of the patient...

  11. 42 CFR 2.52 - Research activities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Research activities. 2.52 Section 2.52 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.52 Research... research if the program director makes a determination that the recipient of the patient...

  12. 42 CFR 2.52 - Research activities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Research activities. 2.52 Section 2.52 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.52 Research... research if the program director makes a determination that the recipient of the patient...

  13. 42 CFR 2.52 - Research activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Research activities. 2.52 Section 2.52 Public... OF ALCOHOL AND DRUG ABUSE PATIENT RECORDS Disclosures Without Patient Consent § 2.52 Research... research if the program director makes a determination that the recipient of the patient...

  14. Disability in instrumental activities of daily living among older adults: gender differences

    PubMed Central

    Alexandre, Tiago da Silva; Corona, Ligiana Pires; Nunes, Daniella Pires; Santos, Jair Lício Ferreira; Duarte, Yeda Aparecida de Oliveira; Lebrão, Maria Lúcia

    2014-01-01

    OBJECTIVE To analyze gender differences in the incidence and determinants of disability regarding instrumental activities of daily living among older adults. METHODS The data were extracted from the Saúde, Bem-Estar e Envelhecimento (SABE – Health, Wellbeing and Ageing) study. In 2000, 1,034 older adults without difficulty in regarding instrumental activities of daily living were selected. The following characteristics were evaluated at the baseline: sociodemographic and behavioral variables, health status, falls, fractures, hospitalizations, depressive symptoms, cognition, strength, mobility, balance and perception of vision and hearing. Instrumental activities of daily living such as shopping and managing own money and medication, using transportation and using the telephone were reassessed in 2006, with incident cases of disability considered as the outcome. RESULTS The incidence density of disability in instrumental activities of daily living was 44.7/1,000 person/years for women and 25.2/1,000 person/years for men. The incidence rate ratio between women and men was 1.77 (95%CI 1.75;1.80). After controlling for socioeconomic status and clinical conditions, the incidence rate ratio was 1.81 (95%CI 1.77;1.84), demonstrating that women with chronic disease and greater social vulnerability have a greater incidence density of disability in instrumental activities of daily living. The following were determinants of the incidence of disability: age ≥ 80 and worse perception of hearing in both genders; stroke in men; and being aged 70 to 79 in women. Better cognitive performance was a protective factor in both genders and better balance was a protective factor in women. CONCLUSIONS The higher incidence density of disability in older women remained even after controlling for adverse social and clinical conditions. In addition to age, poorer cognitive performance and conditions that adversely affect communication disable both genders. Acute events, such as a stroke

  15. Disability in instrumental activities of daily living among older adults: gender differences.

    PubMed

    Alexandre, Tiago da Silva; Corona, Ligiana Pires; Nunes, Daniella Pires; Santos, Jair Lício Ferreira; Duarte, Yeda Aparecida de Oliveira; Lebrão, Maria Lúcia

    2014-06-01

    OBJECTIVE To analyze gender differences in the incidence and determinants of disability regarding instrumental activities of daily living among older adults. METHODS The data were extracted from the Saúde, Bem-Estar e Envelhecimento (SABE - Health, Wellbeing and Ageing) study. In 2000, 1,034 older adults without difficulty in regarding instrumental activities of daily living were selected. The following characteristics were evaluated at the baseline: sociodemographic and behavioral variables, health status, falls, fractures, hospitalizations, depressive symptoms, cognition, strength, mobility, balance and perception of vision and hearing. Instrumental activities of daily living such as shopping and managing own money and medication, using transportation and using the telephone were reassessed in 2006, with incident cases of disability considered as the outcome. RESULTS The incidence density of disability in instrumental activities of daily living was 44.7/1,000 person/years for women and 25.2/1,000 person/years for men. The incidence rate ratio between women and men was 1.77 (95%CI 1.75;1.80). After controlling for socioeconomic status and clinical conditions, the incidence rate ratio was 1.81 (95%CI 1.77;1.84), demonstrating that women with chronic disease and greater social vulnerability have a greater incidence density of disability in instrumental activities of daily living. The following were determinants of the incidence of disability: age ≥ 80 and worse perception of hearing in both genders; stroke in men; and being aged 70 to 79 in women. Better cognitive performance was a protective factor in both genders and better balance was a protective factor in women. CONCLUSIONS The higher incidence density of disability in older women remained even after controlling for adverse social and clinical conditions. In addition to age, poorer cognitive performance and conditions that adversely affect communication disable both genders. Acute events, such as a stroke

  16. An Integrated Extravehicular Activity Research Plan

    NASA Technical Reports Server (NTRS)

    Abercromby, Andrew F. J.; Ross, Amy J.; Cupples, J. Scott

    2016-01-01

    Multiple organizations within NASA and outside of NASA fund and participate in research related to extravehicular activity (EVA). In October 2015, representatives of the EVA Office, the Crew and Thermal Systems Division (CTSD), and the Human Research Program (HRP) at NASA Johnson Space Center agreed on a formal framework to improve multi-year coordination and collaboration in EVA research. At the core of the framework is an Integrated EVA Research Plan and a process by which it will be annually reviewed and updated. The over-arching objective of the collaborative framework is to conduct multi-disciplinary cost-effective research that will enable humans to perform EVAs safely, effectively, comfortably, and efficiently, as needed to enable and enhance human space exploration missions. Research activities must be defined, prioritized, planned and executed to comprehensively address the right questions, avoid duplication, leverage other complementary activities where possible, and ultimately provide actionable evidence-based results in time to inform subsequent tests, developments and/or research activities. Representation of all appropriate stakeholders in the definition, prioritization, planning and execution of research activities is essential to accomplishing the over-arching objective. A formal review of the Integrated EVA Research Plan will be conducted annually. External peer review of all HRP EVA research activities including compilation and review of published literature in the EVA Evidence Book is already performed annually. Coordination with stakeholders outside of the EVA Office, CTSD, and HRP is already in effect on a study-by-study basis; closer coordination on multi-year planning with other EVA stakeholders including academia is being actively pursued. Details of the current Integrated EVA Research Plan are presented including description of ongoing and planned research activities in the areas of: Benchmarking; Anthropometry and Suit Fit; Sensors; Human

  17. [Climate chance and research activity].

    PubMed

    Manuel, Celie

    2009-10-26

    There are three main focus areas relevant to health in research related to climate change: 1) disentangling of the complex associations between climate-sensitive risk factors and health 2) guidance as to where, when and how effective health adaptation strategies may be implemented for maximum effect, and 3) health impact assessment (with a focus on health co-benefits) of climate-related policies in other sectors. Further development in each of these areas will provide important opportunities for strengthening health promotion and protection.

  18. Fatigue, anxiety and depression levels, activities of daily living of patients with chronic obstructive pulmonary disease.

    PubMed

    Karakurt, Papatya; Ünsal, Ayla

    2013-04-01

    The aim of this cross-sectional study was to determine the fatigue, anxiety and depression levels, activities of daily living of patients with chronic obstructive pulmonary disease (n = 255). It was found that there was significant difference between Visual Analogue Scale for Fatigue (VAS-F) point averages and gender, education levels, marital status and economical status of patient with chronic obstructive pulmonary disease. Among the participants in this study, 36.5% had an anxiety disorder whereas 69.0% exhibited depression. In the study, it was determined that 85.5% of those were independent in their Katz's Index of Activities of Daily Living (ADLs) and 49.4% of those were independent in their Lawton and Brody's Index of Instrumental Activities of Daily Living (IADLs). This study has shown that VAS-F, the Hospital Anxiety and Depression Scale, ADL and IADL instruments that measure the various aspects of health-related quality of living can contribute considerably to a more diversified understanding of the patients' situation with chronic obstructive pulmonary disease.

  19. Circadian activity rhythm in pre-pubertal and pubertal marmosets (Callithrix jacchus) living in family groups.

    PubMed

    Melo, Paula R; Gonçalves, Bruno S B; Menezes, Alexandre A L; Azevedo, Carolina V M

    2016-03-01

    In marmosets, a phase advance was observed in activity onset in pubertal animals living in captivity under semi-natural conditions which had stronger correlation with the times of sunrise over the course of the year than the age of the animal. In order to evaluate the effect of puberty on the circadian activity rhythm in male and female marmosets living in family groups in controlled lighting conditions, the activity of 5 dyads of twins (4 ♀/♂ and 1 ♂/♂) and their respective parents was continuously monitored by actiwatches between the 4th and 12th months of age. The families were kept under LD 12:12 h with constant humidity and temperature. The onset of puberty was identified by monitoring fecal steroids. Juveniles showed higher totals of daily activity and differences in the daily distribution of activity in relation to parents, in which the bimodal profile was characterized by higher levels in evening activity in relation to morning activity. Regarding the phase, the activity onset and offset, occurred later in relation to parents. After entering puberty, the activity onset and offset occurred later and there was an increase in total daily activity. On the other hand, when assessing the effect of sex, only females showed a delay in the activity offset and an increase in total daily activity. Therefore, the circadian activity rhythm in marmosets has peculiar characteristics in the juvenile stage in relation to the total of daily activity, the onset and offset of the active phase, and the distribution of activity during this phase. Besides, the entering puberty was associated with a phase delay and increase on total daily activity, with differences between sexes, possibly due to hormonal influences and/or social modulation on rhythm.

  20. Realizing the Living Paper using the ProvONE Model for Reproducible Research

    NASA Astrophysics Data System (ADS)

    Jones, M. B.; Jones, C. S.; Ludäscher, B.; Missier, P.; Walker, L.; Slaughter, P.; Schildhauer, M.; Cuevas-Vicenttín, V.

    2015-12-01

    Science has advanced through traditional publications that codify research results as a permenant part of the scientific record. But because publications are static and atomic, researchers can only cite and reference a whole work when building on prior work of colleagues. The open source software model has demonstrated a new approach in which strong version control in an open environment can nurture an open ecosystem of software. Developers now commonly fork and extend software giving proper credit, with less repetition, and with confidence in the relationship to original software. Through initiatives like 'Beyond the PDF', an analogous model has been imagined for open science, in which software, data, analyses, and derived products become first class objects within a publishing ecosystem that has evolved to be finer-grained and is realized through a web of linked open data. We have prototyped a Living Paper concept by developing the ProvONE provenance model for scientific workflows, with prototype deployments in DataONE. ProvONE promotes transparency and openness by describing the authenticity, origin, structure, and processing history of research artifacts and by detailing the steps in computational workflows that produce derived products. To realize the Living Paper, we decompose scientific papers into their constituent products and publish these as compound objects in the DataONE federation of archival repositories. Each individual finding and sub-product of a reseach project (such as a derived data table, a workflow or script, a figure, an image, or a finding) can be independently stored, versioned, and cited. ProvONE provenance traces link these fine-grained products within and across versions of a paper, and across related papers that extend an original analysis. This allows for open scientific publishing in which researchers extend and modify findings, creating a dynamic, evolving web of results that collectively represent the scientific enterprise. The

  1. Educational Research Capacity Building in the European Union: A Critique of the Lived Experiences of Emerging Researchers

    ERIC Educational Resources Information Center

    Hallet, Fiona; Fidalgo, Patricia

    2014-01-01

    The purpose of this article is to explore the extent to which European Union (EU) policies impact upon the activities of associations such as the European Educational Research Association (EERA) and the experiences of emerging researchers aligned to such associations. In essence, the authors explore potential tensions between policy and the lived…

  2. Effect of Cognitive Rehabilitation on Improving Cognitive Function and Activities of Daily Living among Elderly Patients with Stroke at Assiut University Hospital

    ERIC Educational Resources Information Center

    Abd-Elaziz, Saieda Abd-Elhameed; Khedr, Eman M.; Ahmed, Hanaa Abd Elhakiem; Ibrahim, Hoda Diab Fahmy

    2015-01-01

    Cognitive impairment is a frequent consequence of stroke. The study aimed to measure the effect of cognitive rehabilitation of elderly patients with stroke on their cognitive function and activities of daily living. Quasi experimental research design were used in this study. This study was conducted at neuropsychiatric, physical medicine and…

  3. TARGETED RESEARCH AND TECHNOLOGY WITHIN NASA'S LIVING WITH A STAR PROGRAM.

    SciTech Connect

    Gosling, J. T.; Antiochos, Spiro; Baker, Kile; Bellaire, Paul; Blake, Bern; Crowley, Geoff; Eddy, Jack; Goodrich, Charles; Gopalswamy, Nat; Hesse, Michael; Hurlburt, Neal; Jackman, Charles; Kozyra, Janet; Labonte, Barry; Lean, Judith; Linker, Jon; Mazur, Joe; Onsager, Terry; Sibeck, David

    2003-07-10

    NASA’s Living With a Star (LWS) initiative is a systematic, goal-oriented research program targeting those aspects of the Sun-Earth system that affect society. The Targeted Research and Technology (TR&T) component of LWS provides the theory, modeling, and data analysis necessary to enable an integrated, system-wide picture of Sun-Earth connection science with societal relevance. Recognizing the central and essential role that TR&T would have for the success of the LWS initiative, the LWS Science Architecture Team (SAT) recommended that a Science Definition Team (SDT), with the same status as a flight mission definition team, be formed to design and coordinate a TR&T program having prioritized goals and objectives that focused on practical societal benefits. This report details the SDT recommendations for the TR&T program.

  4. Targeted Research and Technology Within NASA's Living With a Star Program

    NASA Technical Reports Server (NTRS)

    Hesse, Michael

    2003-01-01

    NASA's Living With a Star (LWS) initiative is a systematic, goal-oriented research program targeting those aspects of the Sun-Earth system that affect society. The Targeted Research and Technology (TR&T) component of LWS provides the theory, modeling, and data analysis necessary to enable an integrated, system-wide picture of Sun-Earth connection science with societal relevance. Recognizing the central and essential role that TR&T would have for the success of the LWS initiative, the LWS Science Architecture Team (SAT) recommended that a Science Definition Team (SDT), with the same status as a flight mission definition team, be formed to design and coordinate a TR&T program having prioritized goals and objectives that focused on practical societal benefits. This report details the SDT recommendations for the TR&T program.

  5. Transmission research activities at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Lewicki, D. G.

    1990-01-01

    A joint research program, to advance the technology of rotorcraft transmissions, consists of analytical and experimental efforts to achieve the overall goals of reducing transmission weight and noise, while increasing life and reliability. Recent activities in the areas of transmission and related component research are highlighted. Current areas include specific technologies in support of military rotary wing aviation, gearing technology, transmission noise reduction studies, a recent interest in gearbox diagnostics, and advanced transmission system studies. Results of recent activities are presented along with near term research plans.

  6. Video Observations of Children's Perspectives on Their Lived Experiences: Challenges in the Relations between the Researcher and Children

    ERIC Educational Resources Information Center

    Pálmadóttir, Hrönn; Einarsdóttir, Jóhanna

    2016-01-01

    The article seeks to explore the relationship between the researcher and children aged from one to three years old. The findings are drawn from a research project in an Icelandic preschool where video recordings were used as the main method. The aim of the research project was to understand children's lived experiences when creating their…

  7. Strength and ability to implement the activities of daily living in elderly resident in rural areas

    PubMed Central

    Souza dos Santos, Samara; Carneiro Vasconcelos, Lélia Renata; Alves dos Santos, Clarice

    2016-01-01

    Objective: To examine the association between muscle strength and the ability to perform basic and instrumental activities of daily living in elderly resident in rural areas of Jequie, Brazil. Methods: We performed a cross-sectional design study with a population of 104 individuals aged sixty or older, registered in the Family Health Unit of the district of Itajuru, Jequie-Brazil. Data collection was performed using a standardized instrument used as an interview, followed by the application of tests (bending arm with dumbbell and rising from a chair 30 sec). The basic and instrumental activities of daily living were investigated through the Katz and Lawton scales, respectively. The chi-square test with p ≤0.05 was used as a measure of statistical significance for bivariate analyzes between muscle strength and ability to perform daily activities. Results: The results showed a significant association between muscle strength and dynamic ability to perform activities of daily living. Conclusion: Reduced muscle strength is an important predictor of the functional ability of the elderly. Accordingly, it is recommended to observe muscle strength in actions directed at the elderly. PMID:27821897

  8. Overview of Langley activities in active controls research

    NASA Technical Reports Server (NTRS)

    Abel, I.; Newsom, J. R.

    1981-01-01

    The application of active controls technology to reduce aeroelastic response of aircraft structures offers a potential for significant payoffs in terms of aerodynamic efficiency and weight savings. The activities of the Langley Research Center (laRC) in advancing active controls technology. Activities are categorized into the development of appropriate analysis tools, control law synthesis methodology, and experimental investigations aimed at verifying both analysis and synthesis methodology.

  9. A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells.

    PubMed

    Bertolin, Giulia; Sizaire, Florian; Herbomel, Gaëtan; Reboutier, David; Prigent, Claude; Tramier, Marc

    2016-09-14

    Overexpression of AURKA is a major hallmark of epithelial cancers. It encodes the multifunctional serine/threonine kinase aurora A, which is activated at metaphase and is required for cell cycle progression; assessing its activation in living cells is mandatory for next-generation drug design. We describe here a Förster's resonance energy transfer (FRET) biosensor detecting the conformational changes of aurora kinase A induced by its autophosphorylation on Thr288. The biosensor functionally replaces the endogenous kinase in cells and allows the activation of the kinase to be followed throughout the cell cycle. Inhibiting the catalytic activity of the kinase prevents the conformational changes of the biosensor. Using this approach, we discover that aurora kinase A activates during G1 to regulate the stability of microtubules in cooperation with TPX2 and CEP192. These results demonstrate that the aurora kinase A biosensor is a powerful tool to identify new regulatory pathways controlling aurora kinase A activation.

  10. A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells

    PubMed Central

    Bertolin, Giulia; Sizaire, Florian; Herbomel, Gaëtan; Reboutier, David; Prigent, Claude; Tramier, Marc

    2016-01-01

    Overexpression of AURKA is a major hallmark of epithelial cancers. It encodes the multifunctional serine/threonine kinase aurora A, which is activated at metaphase and is required for cell cycle progression; assessing its activation in living cells is mandatory for next-generation drug design. We describe here a Förster's resonance energy transfer (FRET) biosensor detecting the conformational changes of aurora kinase A induced by its autophosphorylation on Thr288. The biosensor functionally replaces the endogenous kinase in cells and allows the activation of the kinase to be followed throughout the cell cycle. Inhibiting the catalytic activity of the kinase prevents the conformational changes of the biosensor. Using this approach, we discover that aurora kinase A activates during G1 to regulate the stability of microtubules in cooperation with TPX2 and CEP192. These results demonstrate that the aurora kinase A biosensor is a powerful tool to identify new regulatory pathways controlling aurora kinase A activation. PMID:27624869

  11. Eccentric Viewing Training in the Home Environment: Can It Improve the Performance of Activities of Daily Living?

    ERIC Educational Resources Information Center

    Vukicevic, Meri; Fitzmaurice, Kerry

    2009-01-01

    Macular degeneration has a severe impact on a person's ability to perform activities of daily living. This study investigated the impact of in-home training in eccentric viewing on near acuity and performance of activities of daily living. The results suggest that eccentric viewing can ameliorate the impact of the loss of vision that is due to…

  12. Relationship between physical activity and markers of oxidative stress in independent community-living elderly individuals.

    PubMed

    Fraile-Bermúdez, A B; Kortajarena, M; Zarrazquin, I; Maquibar, A; Yanguas, J J; Sánchez-Fernández, C E; Gil, J; Irazusta, A; Ruiz-Litago, F

    2015-10-01

    The aim of the present study was to examine the relationship between objective data of physical activity and markers of oxidative stress in older men and women. Participants were old adults, aged≥60years (61 women and 34 men) who were all capable of performing basic daily activities by themselves and lived on their own. To describe physical activity we used objective data measured by accelerometers which record active and sedentary periods during everyday life for five days. Determination of oxidative stress was conducted from three perspectives: determination plasma total antioxidant status (TAS), plasma antioxidant enzyme activities, i.e., glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD), and membrane lipid peroxidation (TBARS). In the group of women, those who met physical activity recommendations (WR) had lower level of TAS. In addition, the moderate to vigorous physical activity (MVPA) was negatively correlated with TAS. Simultaneously, MVPA was correlated with increase in the GPx antioxidant enzyme activity, and the counts per minute were positively correlated with CAT activity. In the group of men, the cpm and the MVPA were negatively correlated with lipid peroxidation while lifestyle physical activity was positively correlated with CAT activity. These findings suggest that MVPA in the elderly although it is related to a decrease in the TAS in women, induces adaptive increase in antioxidant enzyme activity and decreases lipid peroxidation in both women and men. These results suggest that at this time of life, it is not only the amount of physical activity performed that is important but also its intensity.

  13. Accession Medical Standards Analysis and Research Activity

    DTIC Science & Technology

    2010-01-01

    Chief, Accession Medical Standards Analysis & Research Activity Li Yuanzhang, PhD Senior Statistician Department of Epidemiology David N...ORGANIZATION NAME(S) AND ADDRESS(ES) AMSARA, Department of Epidemiology , Division of Preventive Medicine Walter Reed Army Institute of Research 503... Epidemiology of Injury form the Assessment of Recruit Strength and Motivation study ARMS) and Program

  14. ``Sleeping reactor`` irradiations: Shutdown reactor determination of short-lived activation products

    SciTech Connect

    Jerde, E.A.; Glasgow, D.C.

    1998-09-01

    At the High-Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory, the principal irradiation system has a thermal neutron flux ({phi}) of {approximately} 4 {times} 10{sup 14} n/cm{sup 2} {center_dot} s, permitting the detection of elements via irradiation of 60 s or less. Irradiations of 6 or 7 s are acceptable for detection of elements with half-lives of as little as 30 min. However, important elements such as Al, Mg, Ti, and V have half-lives of only a few minutes. At HFIR, these can be determined with irradiation times of {approximately} 6 s, but the requirement of immediate counting leads to increased exposure to the high activity produced by irradiation in the high flux. In addition, pneumatic system timing uncertainties (about {+-} 0.5 s) make irradiations of < 6 s less reliable. Therefore, the determination of these ultra-short-lived species in mixed matrices has not generally been made at HFIR. The authors have found that very short lived activation products can be produced easily during the period after reactor shutdown (SCRAM), but prior to the removal of spent fuel elements. During this 24- to 36-h period (dubbed the ``sleeping reactor``), neutrons are produced in the beryllium reflector by the reaction {sup 9}Be({gamma},n){sup 8}Be, the gamma rays principally originating in the spent fuel. Upon reactor SCRAM, the flux drops to {approximately} 1 {times} 10{sup 10} n/cm{sup 2} {center_dot} s within 1 h. By the time the fuel elements are removed, the flux has dropped to {approximately} 6 {times} 10{sup 8}. Such fluxes are ideal for the determination of short-lived elements such as Al, Ti, Mg, and V. An important feature of the sleeping reactor is a flux that is not constant.

  15. A cancer detection platform which measures telomerase activity from live circulating tumor cells captured on microfilter

    PubMed Central

    Xu, Tong; Lu, Bo; Tai, Yu-Chong; Goldkorn, Amir

    2010-01-01

    Circulating tumor cells (CTCs) quantified in cancer patients’ blood can predict disease outcome and response to therapy. However, the CTC analysis platforms commonly used cannot capture live CTCs and only apply to tumors of epithelial origin. To address these limitations, we have developed a novel cancer detection platform which measures telomerase activity from live CTCs captured on a Parylene-C slot microfilter. Using a constant low-pressure delivery system, the new microfilter platform was capable of cell capture from 1 ml of whole blood in less than 5 minutes, achieving 90% capture efficiency, 90% cell viability and 200-fold sample enrichment. Importantly, the captured cells retained normal morphology by scanning electron microscopy and could be readily manipulated, further analyzed, or expanded on or off filter. Telomerase activity – a well-recognized universal cancer marker – was reliably detected by qPCR from as few as 25 cancer cells spiked into 7.5 ml whole blood and captured on microfilter. Moreover, significant telomerase activity elevation also was measured from patient blood samples and from single cancer cells lifted off the microfilter. Live CTC capture and analysis is fast and simple yet highly quantitative, versatile, and applicable to nearly all solid tumor types, making this a highly promising new strategy for cancer detection and characterization. PMID:20663903

  16. Effect of computerized cognitive rehabilitation program on cognitive function and activities of living in stroke patients.

    PubMed

    Yoo, Chanuk; Yong, Mi-Hyun; Chung, Jaeyeop; Yang, Yeongae

    2015-08-01

    [Purpose] The objective of this study was to examine the effect of cognitive rehabilitation using a computer on cognitive function and activities of daily living in stroke patients presenting impairment of cognitive function. [Subjects] Forty-six stroke patients were divided into two groups (a training group and control group) through random assignment. [Methods] The training group received rehabilitation therapy and an additional computerized cognitive rehabilitation program using The RehaCom software 30 minutes/day, 5 times/week for 5 weeks. The control group received only rehabilitation therapy including physical and occupational therapy. A comparative analysis on all subjects was conducted before and after the experiment using a cognitive test and activities of daily living test. [Results] After 5 weeks of therapy, the training group presented statistically significant improvement in cognitive function assessment items of digit span, visual span, visual learning, auditory continuous performance, visual continuous performance, and others compared with the control group but did not present statistically significant improvement in activities of daily living. [Conclusion] It was revealed through this study that computerized cognitive rehabilitation with the RehaCom program results in improvement in cognitive function and can be used as a treatment tool beneficial to stroke patients presenting cognitive impairment.

  17. Effect of computerized cognitive rehabilitation program on cognitive function and activities of living in stroke patients

    PubMed Central

    Yoo, Chanuk; Yong, Mi-hyun; Chung, Jaeyeop; Yang, Yeongae

    2015-01-01

    [Purpose] The objective of this study was to examine the effect of cognitive rehabilitation using a computer on cognitive function and activities of daily living in stroke patients presenting impairment of cognitive function. [Subjects] Forty-six stroke patients were divided into two groups (a training group and control group) through random assignment. [Methods] The training group received rehabilitation therapy and an additional computerized cognitive rehabilitation program using The RehaCom software 30 minutes/day, 5 times/week for 5 weeks. The control group received only rehabilitation therapy including physical and occupational therapy. A comparative analysis on all subjects was conducted before and after the experiment using a cognitive test and activities of daily living test. [Results] After 5 weeks of therapy, the training group presented statistically significant improvement in cognitive function assessment items of digit span, visual span, visual learning, auditory continuous performance, visual continuous performance, and others compared with the control group but did not present statistically significant improvement in activities of daily living. [Conclusion] It was revealed through this study that computerized cognitive rehabilitation with the RehaCom program results in improvement in cognitive function and can be used as a treatment tool beneficial to stroke patients presenting cognitive impairment. PMID:26355244

  18. [Research activities in Kobe-Indonesia Collaborative Research Centers].

    PubMed

    Utsumi, Takako; Hayashi, Yoshitake; Hotta, Hak

    2013-01-01

    Kobe-Indonesia Collaborative Research Center was established in Institute of Tropical Disease (ITD), Airlangga University, Surabaya, Indonesia in 2007 under the program of ''Founding Research Centers for Emerging and Reemerging Infectious Diseases'' supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan, and then it has been under the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) since 2010. Japanese researchers have been stationed at ITD, conducting joint researches on influenza, viral hepatitis, dengue and infectious diarrhea. Also, another Japanese researcher has been stationed at Faculty of Medicine, University of Indonesia, Jakarta, carrying out joint researches on'' Identification of anti-hepatitis C virus (HCV) substances and development of HCV and dengue vaccines'' in collaboration with University of Indonesia and Airlangga University through the Science and Technology Research Partnership for Sustainable Development (SATREPS) supported by the Japan Science and Technology Agency (JST) and Japan International Cooperation Agency (JICA) since 2009. In this article, we briefly introduce the background history of Kobe University Research Center in Indonesia, and discuss the research themes and outcomes of J-GRID and SATREPS activities.

  19. Factors associated with past research participation among low-income persons living with HIV.

    PubMed

    Slomka, Jacquelyn; Kypriotakis, Georgios; Atkinson, John; Diamond, Pamela M; Williams, Mark L; Vidrine, Damon J; Andrade, Roberto; Arduino, Roberto

    2012-08-01

    We described influences on past research participation among low-income persons living with HIV (PLWH) and examined whether such influences differed by study type. We analyzed a convenience sample of individuals from a large, urban clinic specializing in treating low-income PLWH. Using a computer-assisted survey, we elicited perceptions of research and participating in research, barriers, benefits, "trigger" influences, and self-efficacy in participating in research. Of 193 participants, we excluded 14 who did not identify any type of study participation, and 17 who identified "other" as study type, resulting in 162 cases for analysis. We compared results among four groups (i.e., 6 comparisons): past medical participants (n=36, 22%), past behavioral participants (n=49, 30%), individuals with no past research participation (n=52, 32%), and persons who had participated in both medical and behavioral studies (n=25, 15%). Data were analyzed using chi-square tests for categorical variables and ANOVA for continuous variables. We employed a multinomial probit (MNP) model to examine the association of multiple factors with the outcome. Confidence in ability to keep appointments, and worry about being a 'guinea pig' showed statistical differences in bivariate analyses. The MNP regression analysis showed differences between and across all 6 comparison groups. Fewer differences were seen across groupings of medical participants, behavioral participants, and those with no past research experience, than in comparisons with the medical-behavioral group. In the MNP regression model 'age' and level of certainty regarding 'keeping yourself from being a guinea pig' showed significant differences between past medical participants and past behavioral participants.

  20. Perceived threat in childhood: a review of research and implications for children living in violent households.

    PubMed

    Miller, Laura E

    2015-04-01

    The current study is a review of existing literature on perceived threat across childhood (0-19 years). There is strong evidence from this body of research that threat detection emerges in infancy and is present throughout childhood, with meaningful links to child adjustment. The wide range of methodologies employed to assess threat include biological measures (event-related potential and functional magnetic resonance imaging), observational data (gaze duration and response time), and a range of ways of gathering cognitive data (threat appraisal). Across methodologies, a uniform finding is that children who have higher threat attenuation are at increased risk for the development of anxiety disorders. It also seems that children's attention to threatening stimuli may vary across development, with heightened attention in infancy and early childhood. These findings have meaningful extensions for children who are living in violent families. Since many children living in violent homes are exposed to the threat of violence beginning in infancy, these children may be at heightened risk as compared to their nonexposed peers for the development of maladaptive patterns of threat detection and response. There is some evidence that this long-standing pattern of vigilance toward threat in key developmental periods may in part explain the increased risk of the development of anxiety disorders and posttraumatic stress disorder following exposure to violence.

  1. Draft Science Topics for ROSES 2017 NASA Living with a Star Targeted Research and Technology Program

    NASA Astrophysics Data System (ADS)

    Linton, Mark; Zesta, Eftyhia

    2016-05-01

    The NASA Living with a Star Targeted Research and Technology (LWS TR&T) steering committee would like to present a draft of the TR&T science topics being developed for ROSES 2017 to the science community for comment at this conference. These topics will be drafted before this conference at the May 2016 steering committee meeting, based on community input and LWS TR&T goals. The committee is seeking community comment on these draft topics before the topics are finalized at the committee's summer meeting and sent to NASA in the committee's 2016 report. The full text of these draft topics will be presented at this poster, and we aim to hold a town hall for community discussion of these topics during this conference. Please see http://lwstrt.gsfc.nasa.gov for more information on the TR&T program, the steering committee and the draft topics.This work was supported by the NASA Living with a Star program.

  2. [Deep-sea research ground for the study of living matter properties in extreme conditions].

    PubMed

    Polikarpov, G G

    2011-01-01

    The Black Sea hollow bottom is a promising research ground in the field of deep-sea radiochemoecology and exobiology. It has turned out to be at the intersection of the earth and cosmic scientific interests such as deep-sea marine radiochemoecology from the perspective of the study of extreme biogeocenological properties of the Earth biosphere and exobiology from the standpoint of the study of life phenomena (living matter) outside the Earth biosphere, i.e. on other planets and during hypothetical transfer of spores in the outer space. The potential of this ground is substantiated with the data published by the author and co-workers on accumulation of 90Sr, 137Cs and Pu isotopes with silts of bathyal pelo-contour, on the quality of deep-sea hydrogen sulphide waters (after their contact with air) for vital functions of planktonic and benthic aerobes, as well as the species composition of marine, freshwater and terrestrial plants grown from the spores collected from the bottom sediments of the Black Sea bathyal. Discussion was based on V.I. Vernadsky's ideas about the living matter and biosphere, which allowed conclusions about the biospheric and outer space role of the described phenomena.

  3. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells.

    PubMed

    Fujinaga, Koh; Luo, Zeping; Schaufele, Fred; Peterlin, B Matija

    2015-01-16

    Regulation of transcription elongation by positive transcription elongation factor b (P-TEFb) plays a central role in determining the state of cell activation, proliferation, and differentiation. In cells, P-TEFb exists in active and inactive forms. Its release from the inactive 7SK small nuclear ribonucleoprotein complex is a critical step for P-TEFb to activate transcription elongation. However, no good method exists to analyze this P-TEFb equilibrium in living cells. Only inaccurate and labor-intensive cell-free biochemical assays are currently available. In this study, we present the first experimental system to monitor P-TEFb activation in living cells. We created a bimolecular fluorescence complementation assay to detect interactions between P-TEFb and its substrate, the C-terminal domain of RNA polymerase II. When cells were treated with suberoylanilide hydroxamic acid, which releases P-TEFb from the 7SK small nuclear ribonucleoprotein, they turned green. Other known P-TEFb-releasing agents, including histone deacetylase inhibitors, bromodomain and extraterminal bromodomain inhibitors, and protein kinase C agonists, also scored positive in this assay. Finally, we identified 5'-azacytidine as a new P-TEFb-releasing agent. This release of P-TEFb correlated directly with activation of human HIV and HEXIM1 transcription. Thus, our visualization of P-TEFb activation by fluorescent complementation assay could be used to find new P-TEFb-releasing agents, compare different classes of agents, and assess their efficacy singly and/or in combination.

  4. Research on Mobile Learning Activities Applying Tablets

    ERIC Educational Resources Information Center

    Kurilovas, Eugenijus; Juskeviciene, Anita; Bireniene, Virginija

    2015-01-01

    The paper aims to present current research on mobile learning activities in Lithuania while implementing flagship EU-funded CCL project on application of tablet computers in education. In the paper, the quality of modern mobile learning activities based on learning personalisation, problem solving, collaboration, and flipped class methods is…

  5. [Feelings and conflicts of women living with HIV/AIDS: a literature research].

    PubMed

    Botti, Maria Luciana; Waidman, Maria Angélica Pagliarini; Marcon, Sonia Silva; Scochi, Maria José

    2009-03-01

    This is a literature review with the purpose to identify how the conflicts and feelings of women living with HIV/AIDS are addressed in the national literature, and the proposed pathways for an integral care approach. Data were collected in November, 2006, in the LILACS database, using the following keywords: women, feelings, HIV, AIDS, suffering, depression and fear. The inclusion criterion was that these studies should have been published in the past five years. The sample was made up of 14 studies (four dissertations, two theses and eight articles). The content analysis method allowed for the identification of three thematic categories: the researcher's perspective, what their perspective identifies and their perspective beyond the physical body--which reveal the necessity of addressing women considering their whole context as human beings, including issues of vulnerability, social gender ideology and the promotion of self-esteem and citizenship.

  6. Living With Ambiguity: A Metasynthesis of Qualitative Research on Mild Cognitive Impairment

    PubMed Central

    Gomersall, Tim; Astell, Arlene; Nygård, Louise; Sixsmith, Andrew; Mihailidis, Alex; Hwang, Amy

    2015-01-01

    Purpose of the study: Mild Cognitive Impairment (MCI) is a diagnosis proposed to describe an intermediate state between normal cognitive aging and dementia. MCI has been criticised for its conceptual fuzziness, its ambiguous relationship to dementia, and the tension it creates between medical and sociological understandings of “normal aging”. Design and Methods: We examined the published qualitative literature on experiences of being diagnosed and living with MCI using metasynthesis as the methodological framework. Results: Two overarching conceptual themes were developed. The first, MCI and myself-in-time, showed that a diagnosis of MCI could profoundly affect a person’s understanding of their place in the world. This impact appears to be mediated by multiple factors including a person’s social support networks, which daily activities are affected, and subjective interpretations of the meaning of MCI. The second theme, Living with Ambiguity, describes the difficulties people experienced in making sense of their diagnosis. Uncertainty arose, in part, from lack of clarity and consistency in the information received by people with MCI, including whether they are even told MCI is the diagnosis. Implications: We conclude by suggesting an ethical tension is always at play when a MCI diagnosis is made. Specifically, earlier support and services afforded by a diagnosis may come at the expense of a person’s anxiety about the future, with continued uncertainty about how his or her concerns and needs can be addressed. PMID:26315317

  7. Dyspnoea with activities of daily living versus peak dyspnoea during exercise in male patients with COPD.

    PubMed

    Oga, Toru; Nishimura, Koichi; Tsukino, Mitsuhiro; Hajiro, Takashi; Mishima, Michiaki

    2006-06-01

    Dyspnoea measurements in chronic obstructive pulmonary disease (COPD) can be broadly divided into two categories: those that assess breathlessness during exercise, and those that assess breathlessness during daily activities. We investigated the relationships between dyspnoea at the end of exercise and during daily activities with clinical measurements and mortality in COPD patients. We examined 143 male outpatients with moderate to very severe COPD. The peak Borg score at the end of progressive cycle ergometry was used for the assessment of peak dyspnoea rating during exercise, and the Baseline Dyspnea Index (BDI) score was used for dyspnoea with activities of daily living. Relationships between these dyspnoea ratings with other clinical measurements of pulmonary function, exercise indices, health status and psychological status were then investigated. In addition, their relationship with the 5-year mortality of COPD patients was also analyzed to examine their predictive ability. Although the BDI score was significantly correlated with airflow limitation, diffusing capacity, exercise indices, health status and psychological status, the Borg score at the end of exercise had non-existent or only weak correlations with them. The BDI score was strongly significantly correlated with mortality, whereas the Borg score was not. Dyspnoea during daily activities was more significantly correlated with objective and subjective measurements of COPD than dyspnoea at the end of exercise. In addition, the former was more predictive of mortality. Dyspnoea with activities of daily living is considered to be a better measurement for evaluating the disease severity of COPD than peak dyspnoea during exercise.

  8. Resistance training increases total energy expenditure and free-living physical activity in older adults.

    PubMed

    Hunter, G R; Wetzstein, C J; Fields, D A; Brown, A; Bamman, M M

    2000-09-01

    The purpose of this study was to determine what effects 26 wk of resistance training have on resting energy expenditure (REE), total free-living energy expenditure (TEE), activity-related energy expenditure (AEE), engagement in free-living physical activity as measured by the activity-related time equivalent (ARTE) index, and respiratory exchange ratio (RER) in 61- to 77-yr-old men (n = 8) and women (n = 7). Before and after training, body composition (four-compartment model), strength, REE, TEE (doubly labeled water), AEE (TEE - REE + thermic response to meals), and ARTE (AEE adjusted for energy cost of standard activities) were evaluated. Strength (36%) and fat-free mass (2 kg) significantly increased, but body weight did not change. REE increased 6.8%, whereas resting RER decreased from 0.86 to 0.83. TEE (12%) and ARTE (38%) increased significantly, and AEE (30%) approached significance (P = 0.06). The TEE increase remained significant even after adjustment for the energy expenditure of the resistance training. In response to resistance training, TEE increased and RER decreased. The increase in TEE occurred as a result of increases in both REE and physical activity. These results suggest that resistance training may have value in increasing energy expenditure and lipid oxidation rates in older adults, thereby improving their metabolic profiles.

  9. Probabilistic learning from incomplete data for recognition of activities of daily living in smart homes.

    PubMed

    Zhang, Shuai; McClean, Sally I; Scotney, Bryan W

    2012-05-01

    Learning behavioral patterns for activities of daily living in a smart home environment can be challenged by the limited number of training data that may be available. This may be due to the infrequent repetition of routine activities (e.g., once daily), the expense of using observers to label activities, and the intrusion that would be caused by the presence of observers over long time periods. It is important, therefore, to make as much use of any labeled data that are collected, however, incomplete these data may be. In this paper, we propose an algorithm for learning behavioral patterns for multi-inhabitants living in a single smart home environment, by making full use of all limited labeled activities, including incomplete data resulting from unreliable low-level sensors in this environment. Through maximum-likelihood estimation, using Expectation-Maximization, we build a model that captures both environmental uncertainties from sensor readings and user uncertainties, including variations in how individuals carry out activities. Our algorithm outperforms models that cannot handle data incompleteness, with increasing performance gains as incompleteness increases. The approach also enables the impact of particular sensors to be assessed and can thus inform sensor maintenance and deployment.

  10. Recognition of Activities of Daily Living with Egocentric Vision: A Review

    PubMed Central

    Nguyen, Thi-Hoa-Cuc; Nebel, Jean-Christophe; Florez-Revuelta, Francisco

    2016-01-01

    Video-based recognition of activities of daily living (ADLs) is being used in ambient assisted living systems in order to support the independent living of older people. However, current systems based on cameras located in the environment present a number of problems, such as occlusions and a limited field of view. Recently, wearable cameras have begun to be exploited. This paper presents a review of the state of the art of egocentric vision systems for the recognition of ADLs following a hierarchical structure: motion, action and activity levels, where each level provides higher semantic information and involves a longer time frame. The current egocentric vision literature suggests that ADLs recognition is mainly driven by the objects present in the scene, especially those associated with specific tasks. However, although object-based approaches have proven popular, object recognition remains a challenge due to the intra-class variations found in unconstrained scenarios. As a consequence, the performance of current systems is far from satisfactory. PMID:26751452

  11. Physical activity levels of economically disadvantaged women living in the Olympic city of Rio de Janeiro.

    PubMed

    de Sousa-Mast, Fabiana R; Reis, Arianne C; Sperandei, Sandro; Gurgel, Luilma A; Vieira, Marcelo C; Pühse, Uwe

    2016-07-01

    The objective of this study was to analyze the physical activity patterns of women living in a low-income community located in close proximity to the 2016 Rio de Janeiro Olympic Park. Data (N = 140) were collected in June and July 2012 using the International Physical Activity Questionnaire. Findings indicated that the majority (54.8%) of participants reported high levels of physical activity. The domains that contributed the most to this pattern were occupational and household physical activity. Significantly, 88.1% of participants reported low physical activity levels during their leisure-time. In the transport-related domain, participants were relatively more active, but more than half of them (57%) spent less than 600 MET-minutes/week in this domain. The results highlighted the discrepancies between different physical activity domains. In addition, the findings also suggested that low-income women in our study engaged little in physical activity during their leisure time. Therefore, the proposed commitments found in the Rio de Janeiro Candidature File to host the 2016 Olympic Games to increase sport/physical activity participation within low-income communities in Rio de Janeiro need to be implemented effectively if this physical activity behavior during self-directed time is to be changed.

  12. Size-dependent regulation of synchronized activity in living neuronal networks

    NASA Astrophysics Data System (ADS)

    Yamamoto, Hideaki; Kubota, Shigeru; Chida, Yudai; Morita, Mayu; Moriya, Satoshi; Akima, Hisanao; Sato, Shigeo; Hirano-Iwata, Ayumi; Tanii, Takashi; Niwano, Michio

    2016-07-01

    We study the effect of network size on synchronized activity in living neuronal networks. Dissociated cortical neurons form synaptic connections in culture and generate synchronized spontaneous activity within 10 days in vitro. Using micropatterned surfaces to extrinsically control the size of neuronal networks, we show that synchronized activity can emerge in a network as small as 12 cells. Furthermore, a detailed comparison of small (˜20 cells), medium (˜100 cells), and large (˜400 cells) networks reveal that synchronized activity becomes destabilized in the small networks. A computational modeling of neural activity is then employed to explore the underlying mechanism responsible for the size effect. We find that the generation and maintenance of the synchronized activity can be minimally described by: (1) the stochastic firing of each neuron in the network, (2) enhancement in the network activity in a positive feedback loop of excitatory synapses, and (3) Ca-dependent suppression of bursting activity. The model further shows that the decrease in total synaptic input to a neuron that drives the positive feedback amplification of correlated activity is a key factor underlying the destabilization of synchrony in smaller networks. Spontaneous neural activity plays a critical role in cortical information processing, and our work constructively clarifies an aspect of the structural basis behind this.

  13. Size-dependent regulation of synchronized activity in living neuronal networks.

    PubMed

    Yamamoto, Hideaki; Kubota, Shigeru; Chida, Yudai; Morita, Mayu; Moriya, Satoshi; Akima, Hisanao; Sato, Shigeo; Hirano-Iwata, Ayumi; Tanii, Takashi; Niwano, Michio

    2016-07-01

    We study the effect of network size on synchronized activity in living neuronal networks. Dissociated cortical neurons form synaptic connections in culture and generate synchronized spontaneous activity within 10 days in vitro. Using micropatterned surfaces to extrinsically control the size of neuronal networks, we show that synchronized activity can emerge in a network as small as 12 cells. Furthermore, a detailed comparison of small (∼20 cells), medium (∼100 cells), and large (∼400 cells) networks reveal that synchronized activity becomes destabilized in the small networks. A computational modeling of neural activity is then employed to explore the underlying mechanism responsible for the size effect. We find that the generation and maintenance of the synchronized activity can be minimally described by: (1) the stochastic firing of each neuron in the network, (2) enhancement in the network activity in a positive feedback loop of excitatory synapses, and (3) Ca-dependent suppression of bursting activity. The model further shows that the decrease in total synaptic input to a neuron that drives the positive feedback amplification of correlated activity is a key factor underlying the destabilization of synchrony in smaller networks. Spontaneous neural activity plays a critical role in cortical information processing, and our work constructively clarifies an aspect of the structural basis behind this.

  14. Examining the Effects of Video Modeling and Prompts to Teach Activities of Daily Living Skills.

    PubMed

    Aldi, Catarina; Crigler, Alexandra; Kates-McElrath, Kelly; Long, Brian; Smith, Hillary; Rehak, Kim; Wilkinson, Lisa

    2016-12-01

    Video modeling has been shown to be effective in teaching a number of skills to learners diagnosed with autism spectrum disorders (ASD). In this study, we taught two young men diagnosed with ASD three different activities of daily living skills (ADLS) using point-of-view video modeling. Results indicated that both participants met criterion for all ADLS. Participants did not maintain mastery criterion at a 1-month follow-up, but did score above baseline at maintenance with and without video modeling. • Point-of-view video models may be an effective intervention to teach daily living skills. • Video modeling with handheld portable devices (Apple iPod or iPad) can be just as effective as video modeling with stationary viewing devices (television or computer). • The use of handheld portable devices (Apple iPod and iPad) makes video modeling accessible and possible in a wide variety of environments.

  15. Acid base activity of live bacteria: Implications for quantifying cell wall charge

    NASA Astrophysics Data System (ADS)

    Claessens, Jacqueline; van Lith, Yvonne; Laverman, Anniet M.; Van Cappellen, Philippe

    2006-01-01

    To distinguish the buffering capacity associated with functional groups in the cell wall from that resulting from metabolic processes, base or acid consumption by live and dead cells of the Gram-negative bacterium Shewanella putrefaciens was measured in a pH stat system. Live cells exhibited fast consumption of acid (pH 4) or base (pH 7, 8, 9, and 10) during the first few minutes of the experiments. At pH 5.5, no acid or base was required to maintain the initial pH constant. The initial amounts of acid or base consumed by the live cells at pH 4, 8, and 10 were of comparable magnitudes as those neutralized at the same pHs by intact cells killed by exposure to gamma radiation or ethanol. Cells disrupted in a French press required higher amounts of acid or base, due to additional buffering by intracellular constituents. At pH 4, acid neutralization by suspensions of live cells stopped after 50 min, because of loss of viability. In contrast, under neutral and alkaline conditions, base consumption continued for the entire duration of the experiments (5 h). This long-term base neutralization was, at least partly, due to active respiration by the cells, as indicated by the build-up of succinate in solution. Qualitatively, the acid-base activity of live cells of the Gram-positive bacterium Bacillus subtilis resembled that of S. putrefaciens. The pH-dependent charging of ionizable functional groups in the cell walls of the live bacteria was estimated from the initial amounts of acid or base consumed in the pH stat experiments. From pH 4 to 10, the cell wall charge increased from near-zero values to about -4 × 10 -16 mol cell -1 and -6.5 × 10 -16 mol cell -1 for S. putrefaciens and B. subtilis, respectively. The similar cell wall charging of the two bacterial strains is consistent with the inferred low contribution of lipopolysaccharides to the buffering capacity of the Gram-negative cell wall (of the order of 10%).

  16. Increase in natural killer cell activity following living-related liver transplantation.

    PubMed

    Hirata, M; Kita, Y; Saito, S; Nishimura, M; Ito, M; Mizuta, K; Tanaka, H; Harihara, Y; Kawarasaki, H; Hashizume, K; Makuuchi, M

    1998-01-01

    We monitored the serial changes of natural killer cell (NK) activity in eight recipients of living-related liver transplantation. The HLA types of all eight patients were haplotypically identical with those of their donors. Tacrolimus and methylprednisolone were used for immunosuppression. The NK activity before transplantation was 24.1 +/- 20.2% which is surprisingly low when compared with the value for normal individuals (67.7 +/- 13.2%, P < 0.01) or a liver dysfunction group (49.4 +/- 21.9%, P < 0.05). Serial changes in NK activity revealed a minimum of 6.1 +/- 3.6% 1 week after transplantation, gradually increasing to 49.2 +/- 12.5% at 2 months after transplantation. These results suggest that the diseased liver might play an important role in the suppression of NK activity.

  17. Harnessing Technology and Citizen Science to Support Neighborhoods that Promote Active Living in Mexico.

    PubMed

    Rosas, Lisa G; Salvo, Deborah; Winter, Sandra J; Cortes, David; Rivera, Juan; Rodriguez, Nicole M; King, Abby C

    2016-12-01

    Middle- and low-income countries bear 80 % of the global chronic disease burden. Population-level, multi-sectoral approaches to promoting healthful lifestyles that take into local physical, socioeconomic, and sociocultural characteristics of both the environment and the population are needed. The "Nuestra Voz (Our Voice)" is one such approach that involves neighborhood residents acting as "citizen scientists" to systematically gather information on the barriers and facilitators of physical activity in their neighborhoods and then use their data to collectively advocate for local environmental- and policy-level changes to support active living. We pilot tested this approach in Cuernavaca, Mexico with adults and adolescents. This community-engaged and participatory approach is driven by residents, who utilize a GPS-enabled electronic tablet-based application with simple audio-based instructions to take photographs and record audio narratives of facets of their neighborhood that promote or hinder active living. After collecting these data, the citizen scientists come together in a community meeting and use their data to prioritize realistic, multi-level changes for promoting active living in their neighborhoods. A survey assessed participants' acceptability of the approach. Participating citizen scientists included 32 adults and 9 adolescents. The citizen scientists rated the acceptability of five of the nine acceptability survey items with an average of 4.0 or higher out of 5.0, indicating they thought it was "fun," were comfortable carrying the tablet, were likely to use it again, and would recommend it to friends and family. Items with average scores of less than 4 were all related to safety concerns. The most common barriers reported by citizen scientists using the tablet were poor sidewalk quality, presence of trash, negative characteristics of the streets, unpleasant aesthetics (e.g., graffiti), and presence of parks and recreational facilities. The Our Voice

  18. Direct measurement of catalase activity in living cells and tissue biopsies.

    PubMed

    Scaglione, Christine N; Xu, Qijin; Ramanujan, V Krishnan

    2016-01-29

    Spatiotemporal regulation of enzyme-substrate interactions governs the decision-making steps in biological systems. Enzymes, being functional units of every living cell, contribute to the macromolecular stability of cell survival, proliferation and hence are vital windows to unraveling the biological complexity. Experimental measurements capturing this dynamics of enzyme-substrate interactions in real time add value to this understanding. Furthermore these measurements, upon validation in realistic biological specimens such as clinical biopsies - can further improve our capability in disease diagnostics and treatment monitoring. Towards this direction, we describe here a novel, high-sensitive measurement system for measuring diffusion-limited enzyme-substrate kinetics in real time. Using catalase (enzyme) and hydrogen peroxide (substrate) as the example pair, we demonstrate that this system is capable of direct measurement of catalase activity in vitro and the measured kinetics follows the classical Michaelis-Menten reaction kinetics. We further demonstrate the system performance by measuring catalase activity in living cells and in very small amounts of liver biopsies (down to 1 μg total protein). Catalase-specific enzyme activity is demonstrated by genetic and pharmacological tools. Finally we show the clinically-relevant diagnostic capability of our system by comparing the catalase activities in liver biopsies from young and old mouse (liver and serum) samples. We discuss the potential applicability of this system in clinical diagnostics as well as in intraoperative surgical settings.

  19. Direct Measurement of Catalase Activity in Living Cells and Tissue Biopsies

    PubMed Central

    Scaglione, Christine N; Xu, Qijin; Ramanujan, V. Krishnan

    2016-01-01

    Spatiotemporal regulation of enzyme-substrate interactions governs the decision-making steps in biological systems. Enzymes, being functional units of every living cell, contribute to the macromolecular stability of cell survival, proliferation and hence are vital windows to unraveling the biological complexity. Experimental measurements capturing this dynamics of enzyme-substrate interactions in real time add value to this understanding. Furthermore these measurements, upon validation in realistic biological specimens such as clinical biopsies – can further improve our capability in disease diagnostics and treatment monitoring. Towards this direction, we describe here a novel, high-sensitive measurement system for measuring diffusion-limited enzyme-substrate kinetics in real time. Using catalase (enzyme) and hydrogen peroxide (substrate) as the example pair, we demonstrate that this system is capable of direct measurement of catalase activity in vitro and the measured kinetics follows the classical Michaelis-Menten reaction kinetics. We further demonstrate the system performance by measuring catalase activity in living cells and in very small amounts of liver biopsies (down to 1μg total protein). Catalase-specific enzyme activity is demonstrated by genetic and pharamacological tools. Finally we show the clinically-relevant diagnostic capability of our system by comparing the catalase activities in liver biopsies from young and old mouse (liver and serum) samples. We discuss the potential applicability of this system in clinical diagnostics as well as in intraoperative surgical settings. PMID:26772884

  20. Assessment of glutamine synthetase activity by [13N]ammonia uptake in living rat brain.

    PubMed

    Momosaki, Sotaro; Ito, Miwa; Tonomura, Misato; Abe, Kohji

    2015-01-01

    Glutamine synthetase (GS) plays an important role in glutamate neurotransmission or neurological disorder in the brain. [(13) N]Ammonia blood flow tracer has been reported to be metabolically trapped in the brain via the glutamate-glutamine pathway. The present study investigated the effect of an inhibitor of GS on [(13) N]ammonia uptake in order to clarify the feasibility of measuring GS activity in the living brain. l-Methionine sulfoximine (MSO), a selective GS inhibitor was microinjected into the ipsilateral striatum in rats. [(13) N]Ammonia uptake was quantified by autoradiography method as well as small animal positron emission tomography (PET) scans. The GS activity of the brain homogenate was assayed from the γ-glutamyl transferase reaction. Autoradiograms showed a decrease of [(13) N]ammonia radioactivity on the MSO-injected side compared with the saline-injected side of the striatum. This reduction could be detected with a small animal PET scanner. MSO had no effect on cerebral blood flow measured by uptake of [(15) O]H2 O. The reduction of [(13) N]ammonia uptake was closely related to the results of GS activity assay. These results indicated that [(13) N]ammonia may enable measurement of GS activity in the living brain.

  1. Relationship between free-living daily physical activity and peripheral circulation in patients with intermittent claudication.

    PubMed

    Gardner, A W; Killewich, L A; Katzel, L I; Womack, C J; Montgomery, P S; Otis, R B; Fonong, T

    1999-04-01

    The purpose of this study was to determine the relationship between free-living daily physical activity and peripheral circulation under resting, reactive hyperemia, and maximal exercise conditions in peripheral arterial occlusive disease (PAOD) patients with intermittent claudication. Sixty-one PAOD patients (age = 70 +/- 6 years, ankle/brachial index [ABI] = 0.57 +/- 0.24) were recruited from the Vascular Clinic at the Baltimore Veterans Affairs Medical Center and from radio and newspaper advertisements. Free-living daily physical activity was measured as the energy expenditure of physical activity (EEPA), determined from doubly labeled water and indirect calorimetry. Patients also were characterized on ankle/brachial index, calf blood flow, calf transcutaneous oxygen tension (TcPO2), and calf transcutaneous heating power (TcHP). ABI and calf blood flow served as markers of the macrocirculation of the lower extremity, while TcPO2 and TcHP served as markers of the microcirculation. The claudication patients were sedentary, reflected by a mean EEPA value of 486 +/- 274 kcal/day. EEPA was related to calf TcHP at rest (282 +/- 24 mW; r = -0.413, p = 0.002), after postocclusion reactive hyperemia (275 +/- 22 mW; r = -0.381, p = 0.004), and after maximal exercise (276 +/- 20 mW; r = -0.461, p<0.001). ABI, calf blood flow, and calf TcPO2 were not related to EEPA under any condition. In conclusion, higher levels of free-living daily physical activity were associated with better microcirculation of the calf musculature in older PAOD patients with intermittent claudication.

  2. An Active Lifestyle is Associated with Better Neurocognitive Functioning in Adults Living with HIV-infection

    PubMed Central

    Fazeli, Pariya L.; Woods, Steven Paul; Heaton, Robert K.; Umlauf, Anya; Gouaux, Ben; Rosario, Debra; Moore, Raeanne C.; Grant, Igor; Moore, David J.

    2014-01-01

    Studies of healthy adults show that engagement in physical, social, and mental activities is associated with better cognitive outcomes, suggesting these activities may increase cognitive reserve. Given the prevalence and real-world impact of HIV-associated neurocognitive disorders (HAND), the present study examined the association between neurocognitive outcomes and self-reported proxies for physical exercise, social activity, and mental activity (employment was used as a proxy for mental activity) among 139 HIV-infected adults (Mage = 48.7; 48% age 50+). Participants completed a neuromedical and neuropsychological battery and were classified based on the number of self-reported active lifestyle factors (ALFs; 0 to 3), including physical exercise, social activity, and current employment. The association between ALFs and both demographically-adjusted average neuropsychological T-scores and HAND diagnoses were examined. Results revealed that an increased number of ALFs was associated with better global neurocognitive performance as well as a lower prevalence of HAND. These cross-sectional findings suggest that an active engagement in life may bolster neurocognitive functioning, perhaps by enhancing cognitive and/or brain reserve. However, an alternative explanation might be that persons with better neurocognitive functioning are more inclined and able to engage in these life activities. Future studies should utilize neuroimaging methodology, longitudinal data, and interventional approaches to establish cause-effect relationships and uncover the neural mechanisms whereby physical, social, and mental stimulation may protect neurocognition via cognitive reserve among those living with HIV. PMID:24554483

  3. Expanding the Partnership of Researchers, Teachers and Parents Through Science Museum Activities

    NASA Astrophysics Data System (ADS)

    Kimura, K.; Hoette, V.

    2008-06-01

    The Science Museum of Tokyo brings science and the general public together through an international collaboration of institutes, universities, and K-12 projects. These include the live science show ``UNIVERSE'', a ``live observing'' program with Hands-On Universe (HOU), Internet telescopes and the constellation cameras i-CAN. We are expanding these activities into formal education in an after-school program. We model partnerships between educators, researchers, university students, teachers and parents to create informal and formal education programs.

  4. Activities at the Smart Structures Research Institute

    NASA Astrophysics Data System (ADS)

    Gardiner, Peter T.

    1991-12-01

    Smart Structures and Materials technology will undoubtedly yield a wide range of new materials plus new sensing and actuation technologies and this will have a radical effect on current approaches to structural design. To meet the multi-disciplinary research challenge posed by this technology, the Smart Structures Research Institute (SSRI) has been established at the University of Strathclyde, Glasgow. This paper describes the background, current and planned activities and progress made in developing this new and very promising technology.

  5. 'A tale of two cases:' the health, illness, and physical activity stories of two children living with cystic fibrosis.

    PubMed

    Moola, Fiona J; Faulkner, Guy E J

    2014-01-01

    Storytelling is perennial, and central to the human condition. Although illness may shatter identity and one's role and place in the broader social world, narrative may aid in the process of self-reparation. Despite the merits of the narrative approach, it has been underutilized with children who are living with cystic fibrosis (CF). The role that illness narratives may play in influencing CF youths' physical activity also remains poorly investigated. This article drew on the qualitative case study methodological tradition to narrate the stories of two children living with CF at a children's hospital in Canada. The findings beg researchers to consider (a) how children with life-limiting diseases borrow multiple illness narrative types, (b) the role of development in influencing the kinds of stories that children can tell, and (c) the impact of illness narratives on physical activity. By rendering the tales of two CF youth in this study, we respond to Aurthur Frank's call; taking a multiple narrative turn, we listen to stories of a different kind of suffering.

  6. The Effect of Reminiscence Therapy on Cognition, Depression, and Activities of Daily Living for Patients With Alzheimer Disease.

    PubMed

    Duru Aşiret, Güler; Kapucu, Sevgisun

    2016-01-01

    The purpose of this study was, conducted with experimental design, to investigate the effect of reminiscence therapy on cognition, depression, activities of daily living of institutionalized mild and moderate Alzheimer patients. The study was conducted with a total of 62 patients (31 intervention group and 31 control group) in four home care in Ankara, Turkey. Study was done between the July 1, 2013 and December 20, 2014. Reminiscence therapy sessions were held with groups consists of 4-5 patients, once a week with 30-35 minute duration for 12 weeks. Standardized Mini Mental Test was used in sample selection. Patients were listed through their mini mental test scores, and randomized as odd numbers to control group and even numbers to intervention group. Data were collected with forms developed by researcher 'Data Sheet' and 'Activities of Daily Living Follow-up Form' as well as scales 'Standardized Mini Mental Test' and 'Geriatric Depression Scale'. Chi-square, Mann Whitney-U test, variance analyses in repeated measures and Bonferroni tests were used for analysis. The increase in mean Standardized Mini Mental Test score and the decrease in mean Geriatric Depression Scale score of the individuals in the intervention group compared to the control group at the end of the reminiscence therapy was statistically significant (P < 0.05). At the end of reminiscence therapy sessions, increase in cognition and decrease in depression were found statistically significant in intervention group.

  7. The menopause transition in women living with HIV: current evidence and future avenues of research.

    PubMed

    Tariq, Shema; Anderson, Jane; Burns, Fiona; Delpech, Valerie; Gilson, Richard; Sabin, Caroline

    2016-04-01

    As the life expectancy of people living with HIV improves as a result of antiretroviral therapy, increasing numbers of women living with HIV (WLHIV) are now reaching menopausal age. The menopause transition in WLHIV remains a relatively overlooked area in clinical HIV research. Whilst there is some evidence to suggest that WLHIV experience menopause at an earlier age and that they have more menopausal symptoms, there is no clear consensus in the literature around an impact of HIV infection on either timing or symptomatology of the menopause. Data are also conflicting on whether HIV-related factors such as HIV viral load and CD4 cell count have an impact on the menopause. Furthermore, menopausal symptoms in WLHIV are known to go under-recognised by both healthcare providers and women themselves. There is likely to be a burden of unmet health needs among WLHIV transitioning through the menopause, with significant gaps in the evidence base for their care. With this in mind, we have developed the PRIME study (Positive Transitions Through the Menopause). This mixed-methods observational study will explore, for the first time in the UK, the impact of the menopause on the health and wellbeing of 1500 ethnically diverse WLHIV. In establishing a cohort of women in their midlife and following them up longitudinally, we hope to develop a nuanced understanding of the gendered aspects of ageing and HIV, informing the provision of appropriate services for WLHIV to ensure that they are supported in maintaining optimal health and wellbeing as they get older.

  8. Prompt gamma activation analysis (PGAA) and short-lived neutron activation analysis (NAA) applied to the characterization of legacy materials

    SciTech Connect

    Firestone, Richard B; English, G.A.; Firestone, R.B.; Perry, D.L.; Reijonen, J.P.; Leung, Ka-Ngo; Garabedian, G.F.; Molnar, G.L.; Revay, Zs.

    2008-02-13

    Without quality historical records that provide the composition of legacy materials, the elemental and/or chemical characterization of such materials requires a manual analytical strategy that may expose the analyst to unknown toxicological hazards. In addition, much of the existing legacy inventory also incorporates radioactivity, and, although radiological composition may be determined by various nuclear-analytical methods, most importantly, gamma-spectroscopy, current methods of chemical characterization still require direct sample manipulation, thereby presenting special problems with broad implications for both the analyst and the environment. Alternately, prompt gamma activation analysis (PGAA) provides a'single-shot' in-situ, non-destructive method that provides a complete assay of all major entrained elemental constituents.1-3. Additionally, neutron activation analysis (NAA) using short-lived activation products complements PGAA and is especially useful when NAA activation surpasses the PGAA in elemental sensitivity.

  9. Wear Testing of Moderate Activities of Daily Living Using In Vivo Measured Knee Joint Loading

    PubMed Central

    Reinders, Jörn; Sonntag, Robert; Vot, Leo; Gibney, Christian; Nowack, Moritz; Kretzer, Jan Philippe

    2015-01-01

    Resumption of daily living activities is a basic expectation for patients provided with total knee replacements. However, there is a lack of knowledge regarding the impact of different activities on the wear performance. In this study the wear performance under application of different daily activities has been analyzed. In vivo load data for walking, walking downstairs/upstairs, sitting down/standing up, and cycling (50 W & 120 W) has been standardized for wear testing. Wear testing of each activity was carried out on a knee wear simulator. Additionally, ISO walking was tested for reasons of comparison. Wear was assessed gravimetrically and wear particles were analyzed. In vivo walking produced the highest overall wear rates, which were determined to be three times higher than ISO walking. Moderate wear rates were determined for walking upstairs and downstairs. Low wear rates were determined for standing up/sitting down and cycling at power levels of 50 W and 120 W. The largest wear particles were observed for cycling. Walking based on in vivo data has been shown to be the most wear-relevant activity. Highly demanding activities (stair climbing) produced considerably less wear. Taking into account the expected number of loads, low-impact activities like cycling may have a greater impact on articular wear than highly demanding activities. PMID:25811996

  10. The Role of Entrepreneurial Activities in Academic Pharmaceutical Science Research

    PubMed Central

    Stinchcomb, Audra L.

    2010-01-01

    Academic pharmaceutical science research is expanding further and further from the University setting to encompass the for-profit private company setting. This parallels the National Institutes of Health momentum to include multiple funding opportunities for University and private company collaboration. It has been recognized that the non-profit and for-profit combination research model can accelerate the commercialization of pharmaceutical products, and therefore more efficiently improve human health. Entrepreneurial activities require unique considerations in the University environment, but can be modeled after the commercialization expansion of the academic healthcare enterprise. Challenges and barriers exist to starting a company as an entrepreneurial faculty member, but the rewards to one's personal and professional lives are incomparable. PMID:20017206

  11. Development and Psychometric Properties of the Instrumental Activities of Daily Living: Compensation Scale

    PubMed Central

    Schmitter-Edgecombe, Maureen; Parsey, Carolyn; Lamb, Richard

    2014-01-01

    The Instrumental Activities of Daily Living – Compensation (IADL-C) scale was developed to capture early functional difficulties and to quantify compensatory strategy use that may mitigate functional decline in the aging population. The IADL-C was validated in a sample of cognitively healthy older adults (N=184) and individuals with mild cognitive impairment (MCI; N=92) and dementia (N=24). Factor analysis and Rasch item analysis led to the 27-item IADL-C informant questionnaire with four functional domain subscales (money and self-management, home daily living, travel and event memory, and social skills). The subscales demonstrated good internal consistency (Rasch reliability 0.80 to 0.93) and test-retest reliability (Spearman coefficients 0.70 to 0.91). The IADL-C total score and subscales showed convergent validity with other IADL measures, discriminant validity with psychosocial measures, and the ability to discriminate between diagnostic groups. The money and self management subscale showed notable difficulties for individuals with MCI, whereas difficulties with home daily living became more prominent for dementia participants. Compensatory strategy use increased in the MCI group and decreased in the dementia group. PMID:25344901

  12. Development and psychometric properties of the instrumental activities of daily living: compensation scale.

    PubMed

    Schmitter-Edgecombe, Maureen; Parsey, Carolyn; Lamb, Richard

    2014-12-01

    The Instrumental Activities of Daily Living - Compensation (IADL-C) scale was developed to capture early functional difficulties and to quantify compensatory strategy use that may mitigate functional decline in the aging population. The IADL-C was validated in a sample of cognitively healthy older adults (N=184) and individuals with mild cognitive impairment (MCI; N=92) and dementia (N=24). Factor analysis and Rasch item analysis led to the 27-item IADL-C informant questionnaire with four functional domain subscales (money and self-management, home daily living, travel and event memory, and social skills). The subscales demonstrated good internal consistency (Rasch reliability 0.80 to 0.93) and test-retest reliability (Spearman coefficients 0.70 to 0.91). The IADL-C total score and subscales showed convergent validity with other IADL measures, discriminant validity with psychosocial measures, and the ability to discriminate between diagnostic groups. The money and self management subscale showed notable difficulties for individuals with MCI, whereas difficulties with home daily living became more prominent for dementia participants. Compensatory strategy use increased in the MCI group and decreased in the dementia group.

  13. 76 FR 35950 - Agency Information Collection Activity (Living Will and Durable Power of Attorney for Health Care...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... Activity (Living Will and Durable Power of Attorney for Health Care) Under OMB Review AGENCY: Department of... INFORMATION Title: Living Will and Durable Power of Attorney for Health Care, VA Form 10-0137. OMB Control... admitted to a VA medical facility complete VA Form 10-0137 to appoint a health care agent to make...

  14. Opposite-polarity motors activate one another to trigger cargo transport in live cells

    PubMed Central

    Ally, Shabeen; Larson, Adam G.; Barlan, Kari; Rice, Sarah E.

    2009-01-01

    Intracellular transport is typically bidirectional, consisting of a series of back and forth movements. Kinesin-1 and cytoplasmic dynein require each other for bidirectional transport of intracellular cargo along microtubules; i.e., inhibition or depletion of kinesin-1 abolishes dynein-driven cargo transport and vice versa. Using Drosophila melanogaster S2 cells, we demonstrate that replacement of endogenous kinesin-1 or dynein with an unrelated, peroxisome-targeted motor of the same directionality activates peroxisome transport in the opposite direction. However, motility-deficient versions of motors, which retain the ability to bind microtubules and hydrolyze adenosine triphosphate, do not activate peroxisome motility. Thus, any pair of opposite-polarity motors, provided they move along microtubules, can activate one another. These results demonstrate that mechanical interactions between opposite-polarity motors are necessary and sufficient for bidirectional organelle transport in live cells. PMID:20038680

  15. "Molecular-Activity Painting": Switch-like, Light-Controlled Perturbations inside Living Cells.

    PubMed

    Chen, Xi; Venkatachalapathy, Muthukumaran; Kamps, Dominic; Weigel, Simone; Kumar, Ravi; Orlich, Michael; Garrecht, Ruben; Hirtz, Michael; Niemeyer, Christof M; Wu, Yao-Wen; Dehmelt, Leif

    2017-03-29

    Acute subcellular protein targeting is a powerful tool to study biological networks. However, signaling at the plasma membrane is highly dynamic, making it difficult to study in space and time. In particular, sustained local control of molecular function is challenging owing to the lateral diffusion of plasma membrane targeted molecules. Herein we present "molecular-activity painting" (MAP), a novel technology which combines photoactivatable chemically induced dimerization (pCID) with immobilized artificial receptors. The immobilization of artificial receptors by surface-immobilized antibodies blocks lateral diffusion, enabling rapid and stable "painting" of signaling molecules and their activity at the plasma membrane with micrometer precision. Using this method, we show that painting of the RhoA-myosin activator GEF-H1 induces patterned acto-myosin contraction inside living cells.

  16. Healthy Living

    MedlinePlus

    ... Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games Brainteasers Puzzles Riddles Songs Activities Be a Scientist Coloring Science Experiments Stories Lessons Topics Games Activities Lessons MENU ...

  17. Regulation of RNA polymerase II activation by histone acetylation in single living cells.

    PubMed

    Stasevich, Timothy J; Hayashi-Takanaka, Yoko; Sato, Yuko; Maehara, Kazumitsu; Ohkawa, Yasuyuki; Sakata-Sogawa, Kumiko; Tokunaga, Makio; Nagase, Takahiro; Nozaki, Naohito; McNally, James G; Kimura, Hiroshi

    2014-12-11

    In eukaryotic cells, post-translational histone modifications have an important role in gene regulation. Starting with early work on histone acetylation, a variety of residue-specific modifications have now been linked to RNA polymerase II (RNAP2) activity, but it remains unclear if these markers are active regulators of transcription or just passive byproducts. This is because studies have traditionally relied on fixed cell populations, meaning temporal resolution is limited to minutes at best, and correlated factors may not actually be present in the same cell at the same time. Complementary approaches are therefore needed to probe the dynamic interplay of histone modifications and RNAP2 with higher temporal resolution in single living cells. Here we address this problem by developing a system to track residue-specific histone modifications and RNAP2 phosphorylation in living cells by fluorescence microscopy. This increases temporal resolution to the tens-of-seconds range. Our single-cell analysis reveals histone H3 lysine-27 acetylation at a gene locus can alter downstream transcription kinetics by as much as 50%, affecting two temporally separate events. First acetylation enhances the search kinetics of transcriptional activators, and later the acetylation accelerates the transition of RNAP2 from initiation to elongation. Signatures of the latter can be found genome-wide using chromatin immunoprecipitation followed by sequencing. We argue that this regulation leads to a robust and potentially tunable transcriptional response.

  18. Monitoring Biosensor Activity in Living Cells with Fluorescence Lifetime Imaging Microscopy

    PubMed Central

    Hum, Julia M.; Siegel, Amanda P.; Pavalko, Fredrick M.; Day, Richard N.

    2012-01-01

    Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor proteins rely on Förster resonance energy transfer (FRET) to report conformational changes in the protein that occur in response to signaling events, and this is commonly measured with intensity-based ratiometric imaging methods. An alternative method for monitoring the activities of the FRET-based biosensor proteins is fluorescence lifetime imaging microscopy (FLIM). FLIM measurements are made in the time domain, and are not affected by factors that commonly limit intensity measurements. In this review, we describe the use of the digital frequency domain (FD) FLIM method for the analysis of FRET signals. We illustrate the methods necessary for the calibration of the FD FLIM system, and demonstrate the analysis of data obtained from cells expressing “FRET standard” fusion proteins. We then use the FLIM-FRET approach to monitor the changes in activities of two different biosensor proteins in specific regions of single living cells. Importantly, the factors required for the accurate determination and reproducibility of lifetime measurements are described in detail. PMID:23203070

  19. Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly.

    PubMed

    Tranah, Gregory J; Lam, Ernest T; Katzman, Shana M; Nalls, Michael A; Zhao, Yiqiang; Evans, Daniel S; Yokoyama, Jennifer S; Pawlikowska, Ludmila; Kwok, Pui-Yan; Mooney, Sean; Kritchevsky, Stephen; Goodpaster, Bret H; Newman, Anne B; Harris, Tamara B; Manini, Todd M; Cummings, Steven R

    2012-09-01

    The decline in activity energy expenditure underlies a range of age-associated pathological conditions, neuromuscular and neurological impairments, disability, and mortality. The majority (90%) of the energy needs of the human body are met by mitochondrial oxidative phosphorylation (OXPHOS). OXPHOS is dependent on the coordinated expression and interaction of genes encoded in the nuclear and mitochondrial genomes. We examined the role of mitochondrial genomic variation in free-living activity energy expenditure (AEE) and physical activity levels (PAL) by sequencing the entire (~16.5 kilobases) mtDNA from 138 Health, Aging, and Body Composition Study participants. Among the common mtDNA variants, the hypervariable region 2 m.185G>A variant was significantly associated with AEE (p=0.001) and PAL (p=0.0005) after adjustment for multiple comparisons. Several unique nonsynonymous variants were identified in the extremes of AEE with some occurring at highly conserved sites predicted to affect protein structure and function. Of interest is the p.T194M, CytB substitution in the lower extreme of AEE occurring at a residue in the Qi site of complex III. Among participants with low activity levels, the burden of singleton variants was 30% higher across the entire mtDNA and OXPHOS complex I when compared to those having moderate to high activity levels. A significant pooled variant association across the hypervariable 2 region was observed for AEE and PAL. These results suggest that mtDNA variation is associated with free-living AEE in older persons and may generate new hypotheses by which specific mtDNA complexes, genes, and variants may contribute to the maintenance of activity levels in late life.

  20. Blood biomonitoring of metals in subjects living near abandoned mining and active industrial areas.

    PubMed

    Madeddu, Roberto; Tolu, Paola; Asara, Yolande; Farace, Cristiano; Forte, Giovanni; Bocca, Beatrice

    2013-07-01

    A human blood biomonitoring campaign to detect the environmental exposure to metals (Cd, Cu, Cr, Mn, Pb and Zn) in 265 subjects was performed in the South-Western part of Sardinia (an Italian island) that is a particular area with a great history of coal and metal mining (Pb/Zn mainly) activities and large industrial structures (as metallurgy). Subjects living near the industrial plant area had geometric means (GM) of blood Cd (0.79 μg/l), Cu (971 μg/l), Mn (12.2 μg/l), and Pb (55.7 μg/l) significantly higher than controls (Cd, 0.47 μg/l; Cu, 900 μg/l; Mn 9.98 μg/l; Pb, 26.5 μg/l) and than people living nearby the past mining sites. Subjects living next to one dismissed mine were statistically higher in blood Cu (GM, 1,022 μg/l) and Pb (GM, 41.4 μg/l) concentrations than controls. No differences were observed in people living in the different mining sites, and this might be related to the decennial disclosure of mines and the adoption of environmental remediation programmes. Some interindividual variables influenced blood biomonitoring data, as smoke and age for Cd, gender for Cu, age, sex and alcohol for Pb, and age for Zn. Moreover, blood metal levels of the whole population were similar to reference values representative of the Sardinian population and acceptably safe according to currently available health guidelines.

  1. Research and technology activities at Ames Research Center's Biomedical Research Division

    NASA Technical Reports Server (NTRS)

    Martello, N.

    1985-01-01

    Various research and technology activities at Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include descriptions of research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, behavior and performance, gravitational biology, and life sciences flight experiments.

  2. The Australian Research Quality Framework: A Live Experiment in Capturing the Social, Economic, Environmental, and Cultural Returns of Publicly Funded Research

    ERIC Educational Resources Information Center

    Donovan, Claire

    2008-01-01

    The author regards development of Australia's ill-fated Research Quality Framework (RQF) as a "live experiment" in determining the most appropriate approach to evaluating the extra-academic returns, or "impact," of a nation's publicly funded research. The RQF was at the forefront of an international movement toward richer…

  3. A Feminine Care Clinical Research Program Transforms Women’s Lives

    PubMed Central

    Tzeghai, Ghebre E.; Ajayi, Funmilayo O.; Miller, Kenneth W.; Imbescheid, Frank; Sobel, Jack D.; Farage, Miranda A.

    2015-01-01

    Feminine hygiene products and menstruation education have transformed the lives of women throughout the world. The P&G Feminine Care Clinical Innovation Research Program has played a key role by expanding scientific knowledge as well as developing technical insights and tools for the development of feminine hygiene products. The aim has been to meet the needs of women throughout their life stages, advancing their urogenital health beyond just menstruation, as well as helping to understand the role of sex hormones in various important health issues that women face. This review article highlights key contributions and research findings in female hygiene products, urogenital health research, and method development. The clinical research team focused on utilizing the results of clinical safety studies to advance the acceptance of feminine hygiene products world-wide. Key findings include that perception of skin sensitivity is not limited to the facial area, but is also relevant to the body and the genital area. Also, they shed light on the role of estrogen in autoimmune diseases as well as premenstrual syndrome. Efforts in the method development area focused on innovative tools that are reliable, predictive of clinical trial results and capable of measuring wear comfort, genital skin health, and the impact of product use on the consumer’s quality of life. A novel method, behind-the-knee (BTK) test, developed to model irritation under normal wear conditions, was the first to account for both chemical and mechanical sources of irritation. The method has been accepted by the FDA as a substitute in clinical trials in some cases, and by American Society for Testing and Materials as a global standard test method. Additional proprietary methods were developed to enhance visual grading of irritation using cross-polarized light, to measure the amount of lotion transferred from sanitary pads, and to evaluate the skin mildness. Finally, the Farage Quality of Life tool was

  4. Effect of combined movement and heart rate monitor placement on physical activity estimates during treadmill locomotion and free-living.

    PubMed

    Brage, Søren; Brage, Niels; Ekelund, Ulf; Luan, Jian'an; Franks, Paul W; Froberg, Karsten; Wareham, Nicholas J

    2006-03-01

    A placement effect on activity measures from movement sensors has been reported during treadmill and free-living activity. Positioning of electrodes may impact on movement artifact susceptibility as well as surface ECG waveform amplitudes and thus potentially on the precision by which heart rate (HR) is ascertained from such ECG traces. The purpose of this study was to examine the extent to which placement of the combined HR and movement sensor, Actiheart, influences measurement of HR and movement, and estimates of energy expenditure. A total of 24 participants (20-39 years, 45-109 kg, 1.54-2.05 m, 19-29 kg m(-2)) were recruited. Whilst wearing two monitors, one placed at the level of the third intercostal space (upper position) and one just below the apex of the sternum (lower position), study participants performed level walking, incline walking, and level running on treadmill, and completed at least one day of free-living monitoring. Placement differences in HR data quality, movement counts, and energy expenditure (estimated from combined HR and movement) were analyzed with regression techniques. Quality of HR data was generally higher when monitors were placed in the lower position. This effect was more pronounced in men during both treadmill activity (relative risk, RR [95% CI] of noisy HR data in upper vs. lower position, RR=1.3[0.3; 5.6] in women, RR=174[14; 2,156] in men) and during free-living (RR=1.2[0.4; 3.3] in women, RR=25[9.6; 67] in men). There were minor placement differences (< or =8%) in movement counts only in women during incline walking and running. During free-living, no placement effect on counts was observed. In all test scenarios, estimates of energy expenditure from the two positions were not significantly different. Positioning the Actiheart at the level below the sternum may yield cleaner HR data. Regardless of which position is used, this has little or no effect on movement counts and energy expenditure estimates, which is encouraging

  5. Amount and intensity of daily living activities in Charcot–Marie–Tooth 1A patients

    PubMed Central

    Menotti, Federica; Laudani, Luca; Damiani, Antonello; Macaluso, Andrea

    2014-01-01

    Background Charcot–Marie–Tooth 1A (CMT1A) patients show a reduction of spontaneous activities of daily living measured by means of questionnaires or pedometers, which are quite inaccurate compared to recent measurement techniques. Aim The study aimed at quantifying daily living activities in CMT1A patients by means of inertial sensors, which give information not only on the amount but also on the intensity of these activities. Materials and methods Time and count (amount), and velocity and power (intensity) of 24 h daily living activities were measured in eight patients (20–48 years; Barthel >90; Tinetti >20) and eight healthy individuals, matched for age and gender, by means of a wearable inertial sensor device. Results There were no differences between patients and controls in the 24-h distance covered and count of steps. However, count of step climbing and sit to stand were lower in patients than in controls (139.93 ± 141.66 vs. 341.06 ± 164.07 n and 58.23 ± 7.82 vs. 65.81 ± 4.75 n, respectively; P < 0.05) as well as mean daily step-climbing and walking velocities (1.07 ± 0.17 vs. 1.21 ± 0.10 m/sec and 1.16 ± 0.31 vs. 1.87 ± 0.50 m/sec, respectively; P < 0.05). In CMT1A patients there was a positive correlation between strength of the knee extensor muscles and both count of steps climbed (R = 0.80) and sit to stand (R = 0.79). Discussion and conclusion The reduced ability of CMT1A patients to carry out activities at high intensity, which was correlated with strength, suggests that strength training might be a rehabilitation tool for improving the 1 ability to carry out these activities. PMID:24653950

  6. Successful live cell harvest from bisected sentinel lymph nodes research report.

    PubMed

    Elliott, Bruce; Cook, Martin G; John, R Justin; Powell, Barry W E M; Pandha, Hardev; Dalgleish, Angus G

    2004-08-01

    Sentinel lymph nodes provide an excellent opportunity to study early immune responses to cancer. However, harvesting live cells has not previously been possible, because it conflicts with the need to preserve tissue for histological interpretation. This study used scrape cytology on 26 sentinel and 8 non-sentinel nodes, harvested from 17 stage I/II melanoma patients undergoing sentinel node biopsy. Numbers of viable cells harvested before and after cryopreservation were measured and the effect on subsequent histology assessed. The mean number of cells harvested from 26 sentinel nodes was 7.06 x 10(6) (range 0.1-32.2), with a mean viability of 99.5% (range 87-100, lower 95% CI 98.5%). Furthermore, counts and viabilities were well maintained after cryopreservation. Flow cytometry confirmed CD3+, CD20+ and lineage-1-/HLA-DR+ subpopulations, consistent with T-lymphocytes, B-lymphocytes and dendritic cells, respectively. Importantly, there was no discernible change in histological detail and the proportion of positive sentinel nodes remained unchanged. This technique will allow more functional and quantitative approaches to sentinel lymph node research.

  7. Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells

    NASA Astrophysics Data System (ADS)

    Lu, Shaoying; Seong, Jihye; Wang, Yi; Chang, Shiou-Chi; Eichorst, John Paul; Ouyang, Mingxing; Li, Julie Y.-S.; Chien, Shu; Wang, Yingxiao

    2014-07-01

    Focal adhesions (FAs) are dynamic subcellular structures crucial for cell adhesion, migration and differentiation. It remains an enigma how enzymatic activities in these local complexes regulate their structural remodeling in live cells. Utilizing biosensors based on fluorescence resonance energy transfer (FRET), we developed a correlative FRET imaging microscopy (CFIM) approach to quantitatively analyze the subcellular coordination between the enzymatic Src activation and the structural FA disassembly. CFIM reveals that the Src kinase activity only within the microdomain of lipid rafts at the plasma membrane is coupled with FA dynamics. FA disassembly at cell periphery was linearly dependent on this raft-localized Src activity, although cells displayed heterogeneous levels of response to stimulation. Within lipid rafts, the time delay between Src activation and FA disassembly was 1.2 min in cells seeded on low fibronectin concentration ([FN]) and 4.3 min in cells on high [FN]. CFIM further showed that the level of Src-FA coupling, as well as the time delay, was regulated by cell-matrix interactions, as a tight enzyme-structure coupling occurred in FA populations mediated by integrin αvβ3, but not in those by integrin α5β1. Therefore, different FA subpopulations have distinctive regulation mechanisms between their local kinase activity and structural FA dynamics.

  8. A new clinical tool for assessing numerical abilities in neurological diseases: numerical activities of daily living

    PubMed Central

    Semenza, Carlo; Meneghello, Francesca; Arcara, Giorgio; Burgio, Francesca; Gnoato, Francesca; Facchini, Silvia; Benavides-Varela, Silvia; Clementi, Maurizio; Butterworth, Brian

    2014-01-01

    The aim of this study was to build an instrument, the numerical activities of daily living (NADL), designed to identify the specific impairments in numerical functions that may cause problems in everyday life. These impairments go beyond what can be inferred from the available scales evaluating activities of daily living in general, and are not adequately captured by measures of the general deterioration of cognitive functions as assessed by standard clinical instruments like the MMSE and MoCA. We assessed a control group (n = 148) and a patient group affected by a wide variety of neurological conditions (n = 175), with NADL along with IADL, MMSE, and MoCA. The NADL battery was found to have satisfactory construct validity and reliability, across a wide age range. This enabled us to calculate appropriate criteria for impairment that took into account age and education. It was found that neurological patients tended to overestimate their abilities as compared to the judgment made by their caregivers, assessed with objective tests of numerical abilities. PMID:25126077

  9. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations.

    PubMed

    Jansen, J; De Napoli, I E; Fedecostante, M; Schophuizen, C M S; Chevtchik, N V; Wilmer, M J; van Asbeck, A H; Croes, H J; Pertijs, J C; Wetzels, J F M; Hilbrands, L B; van den Heuvel, L P; Hoenderop, J G; Stamatialis, D; Masereeuw, R

    2015-11-16

    The bioartificial kidney (BAK) aims at improving dialysis by developing 'living membranes' for cells-aided removal of uremic metabolites. Here, unique human conditionally immortalized proximal tubule epithelial cell (ciPTEC) monolayers were cultured on biofunctionalized MicroPES (polyethersulfone) hollow fiber membranes (HFM) and functionally tested using microfluidics. Tight monolayer formation was demonstrated by abundant zonula occludens-1 (ZO-1) protein expression along the tight junctions of matured ciPTEC on HFM. A clear barrier function of the monolayer was confirmed by limited diffusion of FITC-inulin. The activity of the organic cation transporter 2 (OCT2) in ciPTEC was evaluated in real-time using a perfusion system by confocal microscopy using 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) as a fluorescent substrate. Initial ASP(+) uptake was inhibited by a cationic uremic metabolites mixture and by the histamine H2-receptor antagonist, cimetidine. In conclusion, a 'living membrane' of renal epithelial cells on MicroPES HFM with demonstrated active organic cation transport was successfully established as a first step in BAK engineering.

  10. Real-time detecting gelatinases activity in living cells by FRET imaging

    NASA Astrophysics Data System (ADS)

    Yang, Jie; Zhang, Zhihong; Liu, Bifeng; Luo, Qingming

    2006-01-01

    Degradation of the extracellular matrix by Matrix metalloproteinases (MMPs) not only enhances tumor invasion, but also affects tumor cell behaviour and leads to cancer progression. To monitor gelatinases (contain MMP2 and MMP9) activity in living cells, we constructed a vector that encoded a gelatinases recognition site (GRS) between citrine (mutation of EYFP Q69M) in N terminal and ECFP in C terminal. Because Gelatinases are secretory proteins and act outside of cell, an expressing vector displayed the fusion protein on cellular surface was used for this FRET gene probe. On expression of YFP-GRS-ECFP in MCF-7 cells that expressed no gelatinases, we were able to observe the efficient transfer of energy from excited ECFP to YFP within the YFP-GRS-ECFP molecule. However, the fusion protein YFP-GRS-ECFP was expressed in MDA-MB 453s cell line with high secretory gelatinases, so YFP-GRS-ECFP was cleaved by gelatinases, no such transfer of energy was detected and fluorescence signal disappeared in YFP channel since YFP protein was cut down. Moreover, Doxycycline, a MMP inhibitor, could make FRET signal increase and fluorescence signal appeared in YFP channel. Thus, the FRET probe YFP-GRS-ECFP can sensitively and reliably monitor gelatinases activation in living cells and can be used for screening MMP inhibitors.

  11. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations

    PubMed Central

    Jansen, J.; De Napoli, I. E; Fedecostante, M.; Schophuizen, C. M. S.; Chevtchik, N. V.; Wilmer, M. J.; van Asbeck, A. H.; Croes, H. J.; Pertijs, J. C.; Wetzels, J. F. M.; Hilbrands, L. B.; van den Heuvel, L. P.; Hoenderop, J. G.; Stamatialis, D.; Masereeuw, R.

    2015-01-01

    The bioartificial kidney (BAK) aims at improving dialysis by developing ‘living membranes’ for cells-aided removal of uremic metabolites. Here, unique human conditionally immortalized proximal tubule epithelial cell (ciPTEC) monolayers were cultured on biofunctionalized MicroPES (polyethersulfone) hollow fiber membranes (HFM) and functionally tested using microfluidics. Tight monolayer formation was demonstrated by abundant zonula occludens-1 (ZO-1) protein expression along the tight junctions of matured ciPTEC on HFM. A clear barrier function of the monolayer was confirmed by limited diffusion of FITC-inulin. The activity of the organic cation transporter 2 (OCT2) in ciPTEC was evaluated in real-time using a perfusion system by confocal microscopy using 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) as a fluorescent substrate. Initial ASP+ uptake was inhibited by a cationic uremic metabolites mixture and by the histamine H2-receptor antagonist, cimetidine. In conclusion, a ‘living membrane’ of renal epithelial cells on MicroPES HFM with demonstrated active organic cation transport was successfully established as a first step in BAK engineering. PMID:26567716

  12. A review of reproductive health research, guidelines and related gaps for women living with HIV.

    PubMed

    Loutfy, Mona R; Sonnenberg-Schwan, Ulrike; Margolese, Shari; Sherr, Lorraine

    2013-01-01

    The study of pregnancy and motherhood in women living with HIV (WLWH) has concentrated on the health of the unborn baby and the prevention of mother-to-child transmission, whereas consideration of the broader aspects of women's reproductive health has been largely overlooked. The rights of WLWH with respect to their reproductive health should be exactly the same as non-HIV-positive women, however, inequalities exist due to discrimination and also because the treatment guidelines used in the care of women are often based on insufficient evidence. The purpose of this article is to review the available literature on reproductive health issues for WLWH and to identify gaps requiring further investigation. Our review indicates that further research is warranted into a number of aspects of reproductive health among WLWH. Currently, access to the relevant reproductive health resources and services, such as advice on contraception and fertility services, for WLWH is far from optimal in many developed countries and most developing countries. More data are needed on the most appropriate family planning options with the consideration of drug interactions between contraceptives and antiretroviral therapy and the risk of HIV transmission. Also, more research is needed to improve understanding of the maternal health challenges facing WLWH. Similarly, our understanding of the impact of HIV on the physical and emotional health of pregnant women and new mothers is far from complete. Answering these questions and countering these inequalities will help to ensure the reproductive health and child-bearing intentions of WLWH become an integral part of HIV medicine.

  13. Development of an open technology sensor suite for assisted living: a student-led research project

    PubMed Central

    Hughes, Josephine A. E.; Bonner, Oliver; Amjad, Omar A.; Levdik, Vitaly; Hall, Richard D.; Baekelandt, Géraldine; Hutter, Tanya; Kaminski, Clemens F.

    2016-01-01

    Many countries have a rapidly ageing population, placing strain on health services and creating a growing market for assistive technology for older people. We have, through a student-led, 12-week project for 10 students from a variety of science and engineering backgrounds, developed an integrated sensor system to enable older people, or those at risk, to live independently in their own homes for longer, while providing reassurance for their family and carers. We provide details on the design procedure and performance of our sensor system and the management and execution of a short-term, student-led research project. Detailed information on the design and use of our devices, including a door sensor, power monitor, fall detector, general in-house sensor unit and easy-to-use location-aware communications device, is given, with our open designs being contrasted with closed proprietary systems. A case study is presented for the use of our devices in a real-world context, along with a comparison with commercially available systems. We discuss how the system could lead to improvements in the quality of life of older users and increase the effectiveness of their associated care network. We reflect on how recent developments in open source technology and rapid prototyping increase the scope and potential for the development of powerful sensor systems and, finally, conclude with a student perspective on this team effort and highlight learning outcomes, arguing that open technologies will revolutionize the way in which technology will be deployed in academic research in the future. PMID:27499844

  14. Development of an open technology sensor suite for assisted living: a student-led research project.

    PubMed

    Manton, James D; Hughes, Josephine A E; Bonner, Oliver; Amjad, Omar A; Mair, Philip; Miele, Isabella; Wang, Tiesheng; Levdik, Vitaly; Hall, Richard D; Baekelandt, Géraldine; Vasconcellos, Fernando da Cruz; Hadeler, Oliver; Hutter, Tanya; Kaminski, Clemens F

    2016-08-06

    Many countries have a rapidly ageing population, placing strain on health services and creating a growing market for assistive technology for older people. We have, through a student-led, 12-week project for 10 students from a variety of science and engineering backgrounds, developed an integrated sensor system to enable older people, or those at risk, to live independently in their own homes for longer, while providing reassurance for their family and carers. We provide details on the design procedure and performance of our sensor system and the management and execution of a short-term, student-led research project. Detailed information on the design and use of our devices, including a door sensor, power monitor, fall detector, general in-house sensor unit and easy-to-use location-aware communications device, is given, with our open designs being contrasted with closed proprietary systems. A case study is presented for the use of our devices in a real-world context, along with a comparison with commercially available systems. We discuss how the system could lead to improvements in the quality of life of older users and increase the effectiveness of their associated care network. We reflect on how recent developments in open source technology and rapid prototyping increase the scope and potential for the development of powerful sensor systems and, finally, conclude with a student perspective on this team effort and highlight learning outcomes, arguing that open technologies will revolutionize the way in which technology will be deployed in academic research in the future.

  15. Behavioral Intention to Use a Virtual Instrumental Activities of Daily Living System Among People With Stroke

    PubMed Central

    Adams, Richard; White, Marga; Diamond, Paul

    2015-01-01

    OBJECTIVE. The purpose of this study was to investigate the behavioral intention to use (BIU) regarding a virtual system for practicing instrumental activities of daily living (IADLs) among people with stroke. METHOD. Fourteen people who had sustained a stroke used a virtual world–based system over four sessions to participate in virtual occupations of preparing meals and putting away groceries. To investigate intention to use the technology, participants responded to a questionnaire based on the Technology Acceptance Model and were interviewed about the experience. RESULTS. Analysis of questionnaire responses revealed favorable attitudes toward the technology and statistically significant correlations between these attitudes and positive BIU. Analysis of qualitative data revealed four themes to support system use: Use of the affected arm increased, the virtual practice was enjoyable, the technology was user-friendly, and the system reflected real-life activities. CONCLUSION. This study shows that participants reported a positive BIU for the virtual system for practicing IADLs. PMID:25871604

  16. Vision based assistive technology for people with dementia performing activities of daily living (ADLs): an overview

    NASA Astrophysics Data System (ADS)

    As'ari, M. A.; Sheikh, U. U.

    2012-04-01

    The rapid development of intelligent assistive technology for replacing a human caregiver in assisting people with dementia performing activities of daily living (ADLs) promises in the reduction of care cost especially in training and hiring human caregiver. The main problem however, is the various kinds of sensing agents used in such system and is dependent on the intent (types of ADLs) and environment where the activity is performed. In this paper on overview of the potential of computer vision based sensing agent in assistive system and how it can be generalized and be invariant to various kind of ADLs and environment. We find that there exists a gap from the existing vision based human action recognition method in designing such system due to cognitive and physical impairment of people with dementia.

  17. Small-molecule FRET probes for protein kinase activity monitoring in living cells

    SciTech Connect

    Vaasa, Angela; Lust, Marje; Terrin, Anna; Uri, Asko; Zaccolo, Manuela

    2010-07-09

    In this study, the applicability of fluorescently labeled adenosine analogue-oligoarginine conjugates (ARC-Photo probes) for monitoring of protein kinase A (PKA) activity in living cells was demonstrated. ARC-Photo probes possessing subnanomolar affinity towards the catalytic subunit of PKA (PKAc) and competitive with the regulatory subunit (PKAr), penetrate cell plasma membrane and associate with PKAc fused with yellow fluorescent protein (PKAc-YFP). Detection of inter-molecular Foerster resonance energy transfer (FRET) efficiency between the fluorophores of the fusion protein and ARC-Photo probe can be used for both the evaluation of non-labeled inhibitors of PKAc and for monitoring of cAMP signaling via detection of changes in the activity of PKA as a cAMP downstream effector.

  18. Validation of Taiwan Performance-Based Instrumental Activities of Daily Living (TPIADL), a Performance- Based Measurement of Instrumental Activities of Daily Living for Patients with Vascular Cognitive Impairment

    PubMed Central

    Chen, Hui-Mei; Lin, Hsiu-Fen; Huang, Mei-Feng; Chang, Chun-Wei; Yeh, Yi-Chun; Lo, Yi-Ching; Yen, Cheng-Fang; Chen, Cheng-Sheng

    2016-01-01

    Objective Patients with cerebrovascular diseases often presented both cognitive and physical impairment. Disability in everyday functioning involving cognitive impairment among patients may be hard to completely rely on informants’ reports, as their reports may be confounded with physical impairment. The aim of this study was to validate a performance-based measure of functional assessment, the Taiwan Performance-Based Instrumental Activities of Daily Living (TPIADL), for vascular cognitive impairment (VCI) by examining its psychometric properties and diagnostic accuracy. Methods Ninety-seven patients with cerebrovascular diseases, including 30 with vascular dementia (VaD), 28 with mild cognitive impairment and 39 with no cognitive impairment, and 49 healthy control adults were recruited during study period. The TPIADL, as well as the Mini Mental State Examination (MMSE), Lawton-IADL and Barthel Index (BI), were performed. The internal consistency, convergent and criteria validity of the TPIADL were examined. Results Cronbach’s alpha of the TPIADL test was 0.84. The TPIADL scores were significantly correlated with the Lawton IADL (r = –0.587, p <0.01). Notably, the TPIADL had a higher correlation coefficient with the cognitive domain of Lawton IADL (r = –0.663) than with physical domain of Lawton IADL (r = –0.541). The area under the relative operating characteristic curve was 0.888 (95% CI = 0.812–0.965) to differentiate VaD from other groups. The optimal cut-off point of the TPIADL for detecting VaD was 6/7, which gives a sensitivity of 73.3% and a specificity of 84.5%. Conclusion The TPIADL is a brief and sensitive tool for the detection of IADL impairment in patients with VaD. PMID:27851810

  19. Relationship of Having Hobbies and a Purpose in Life With Mortality, Activities of Daily Living, and Instrumental Activities of Daily Living Among Community-Dwelling Elderly Adults

    PubMed Central

    Tomioka, Kimiko; Kurumatani, Norio; Hosoi, Hiroshi

    2016-01-01

    Background This study’s aim was to clarify the relationship of having hobbies and a purpose in life (PIL; in Japanese, ikigai) with mortality and a decline in the activities of daily living (ADL) and instrumental ADL (IADL) among the community-dwelling elderly. Methods Prospective observational data from residents aged ≥65 years who were at increased risk for death (n = 1853) and developing a decline in ADL (n = 1254) and IADL (n = 1162) were analyzed. Cox proportional hazard models were used for mortality analysis of data from February 2011 to November 2014. ADL and IADL were evaluated using the Barthel Index and the Tokyo Metropolitan Institute of Gerontology Index of Competence, respectively. ADL and IADL were assessed at baseline and follow-up and were evaluated using logistic regression models. Fully adjusted models included terms for age, gender, BMI, income, alcohol intake, smoking history, number of chronic diseases, cognitive function, and depression. Results During the follow-up of eligible participants, 248 had died, 119 saw a decline in ADL, and 178 saw a decline in IADL. In fully adjusted models, having neither hobbies nor PIL was significantly associated with an increased risk of mortality (hazard ratio 2.08; 95% confidence interval [CI], 1.47–2.94), decline in ADL (odds ratio 2.74; 95% CI, 1.44–5.21), and decline in IADL (odds ratio 1.89; 95% CI, 1.01–3.55) compared to having both hobbies and PIL. Conclusions Although effect modifications by cognitive functioning and depression cannot be ruled out, our findings suggest that having hobbies and PIL may extend not only longevity, but also healthy life expectancy among community-dwelling older adults. PMID:26947954

  20. Using Rasch Analysis to Evaluate Accuracy of Individual Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) for Disability Measurement.

    PubMed

    Friedman, Bruce; Li, Yanen

    2015-01-01

    Our study objectives were to examine the accuracy of individual activities of daily living (ADLs) and instrumental ADLs (IADLs) for disability measurement, and determine whether dependence or difficulty is more useful for disability measurement. We analyzed data from 499 patients with 2+ ADLs or 3+ IADLs who participated in a home visiting nurse intervention study, and whose function had been assessed at study baseline and 22 months. Rasch analysis was used to evaluate accuracy of 24 individual ADL and IADL items. The individual items differed in the amount of information provided in measuring functional disability along the range of disability, providing much more information in (usually) one part of the range. While nearly all of the Item Information Curves (IICs) for the ADL dependence, IADL difficulty, and IADL dependence items were unimodal with one information peak each, the IICs for ADL difficulty exhibited a bimodal pattern with two peaks. Which of the individual items performed better in disability measurement varied by the extent of functional disability (i.e., by how disabled the patients were). The information peaks of most ADLs and many IADLs rise or drop steeply in a relatively short distance. Thus, whether dependence or difficulty is superior often changes very quickly along the disability continuum. There was considerable heterogeneity in which individual items provided the most and the least information at the three points of interest examined across the disability range (-2 SD units, mean, +2 SD units). While the disability region (low, medium, and high disability) for which each individual item provided the most information remained quite stable between baseline and 22 months for ADL difficulty, IADL difficulty, and IADL dependence, relatively large shifts occurred for ADL dependence items. At the disability mean dependence items offered more information for assessment than difficulty. While ADLs also provided more information at -2 and +2 SD

  1. Pathomimetic cancer avatars for live-cell imaging of protease activity.

    PubMed

    Ji, Kyungmin; Heyza, Joshua; Cavallo-Medved, Dora; Sloane, Bonnie F

    2016-03-01

    Proteases are essential for normal physiology as well as multiple diseases, e.g., playing a causative role in cancer progression, including in tumor angiogenesis, invasion, and metastasis. Identification of dynamic alterations in protease activity may allow us to detect early stage cancers and to assess the efficacy of anti-cancer therapies. Despite the clinical importance of proteases in cancer progression, their functional roles individually and within the context of complex protease networks have not yet been well defined. These gaps in our understanding might be addressed with: 1) accurate and sensitive tools and methods to directly identify changes in protease activities in live cells, and 2) pathomimetic avatars for cancer that recapitulate in vitro the tumor in the context of its cellular and non-cellular microenvironment. Such avatars should be designed to facilitate mechanistic studies that can be translated to animal models and ultimately the clinic. Here, we will describe basic principles and recent applications of live-cell imaging for identification of active proteases. The avatars optimized by our laboratory are three-dimensional (3D) human breast cancer models in a matrix of reconstituted basement membrane (rBM). They are designated mammary architecture and microenvironment engineering (MAME) models as they have been designed to mimic the structural and functional interactions among cell types in the normal and cancerous human breast. We have demonstrated the usefulness of these pathomimetic avatars for following dynamic and temporal changes in cell:cell interactions and quantifying changes in protease activity associated with these interactions in real-time (4D). We also briefly describe adaptation of the avatars to custom-designed and fabricated tissue architecture and microenvironment engineering (TAME) chambers that enhance our ability to analyze concomitant changes in the malignant phenotype and the associated tumor microenvironment.

  2. Using Citizen Scientists to Gather, Analyze, and Disseminate Information About Neighborhood Features That Affect Active Living.

    PubMed

    Winter, Sandra J; Goldman Rosas, Lisa; Padilla Romero, Priscilla; Sheats, Jylana L; Buman, Matthew P; Baker, Cathleen; King, Abby C

    2016-10-01

    Many Latinos are insufficiently active, partly due to neighborhoods with little environmental support for physical activity. Multi-level approaches are needed to create health-promoting neighborhoods in disadvantaged communities. Participant "citizen scientists" were adolescent (n = 10, mean age = 12.8 ± 0.6 years) and older adult (n = 10, mean age = 71.3 ± 6.5 years), low income Latinos in North Fair Oaks, California. Citizen scientists conducted environmental assessments to document perceived barriers to active living using the Stanford Healthy Neighborhood Discovery Tool, which records GPS-tracked walking routes, photographs, audio narratives, and survey responses. Using a community-engaged approach, citizen scientists subsequently attended a community meeting to engage in advocacy training, review assessment data, prioritize issues to address and brainstorm potential solutions and partners. Citizen scientists each conducted a neighborhood environmental assessment and recorded 366 photographs and audio narratives. Adolescents (n = 4), older adults (n = 7) and community members (n = 4) collectively identified reducing trash and improving personal safety and sidewalk quality as the priority issues to address. Three adolescent and four older adult citizen scientists volunteered to present study findings to key stakeholders. This study demonstrated that with minimal training, low-income, Latino adolescent and older adult citizen scientists can: (1) use innovative technology to gather information about features of their neighborhood environment that influence active living, (2) analyze their information and identify potential solutions, and (3) engage with stakeholders to advocate for the development of healthier neighborhoods.

  3. Research to Practice: Implementing Physical Activity Recommendations

    PubMed Central

    Davis, Sally M.; Cruz, Theresa H.; Kozoll, Richard

    2016-01-01

    Introduction Dissemination and implementation (D&I) science focuses on bridging the gap between research and practice. The Community Preventive Services Task Force (CPSTF) published recommendations for increasing physical activity based on scientific review and consensus. Little research on the D&I of these recommendations has been conducted in under-represented populations at high risk for inactivity and chronic disease. Methods Partnering with one rural community (beta site), the University of New Mexico Prevention Research Center studied the translation of CPSTF recommendations to practice. Strategies for increasing physical activity were selected, implemented, and analyzed in 2009 to 2013. Participant observations; content analysis of meeting minutes, field notes, and other documents; and in-depth interviews were conducted over the 5-year period to identify factors important for carrying out the CPSTF recommendations for physical activity in a rural New Mexico community. Results Included among the implementation outcomes were new sidewalks and trails, a community-wide campaign, social support of walking, and park improvements. The following factors were identified as important to the implementation process: an active community-academic partnership; multiple partners; culturally appropriate strategies; and approaches that fit local context and place characteristics (topography, land ownership, population clusters, existing roadways). Conclusions This study illustrates how evidence can be translated to practice and identifies key factors in that process. The successful beta model provides a practical blueprint for D&I in rural, under-represented populations. This model is currently being disseminated (scaled up) to other rural New Mexico communities. PMID:28215385

  4. Interwoven Lives: Adolescent Mothers and Their Children. Research Monographs in Adolescence.

    ERIC Educational Resources Information Center

    Whitman, Thomas L.; Borkowski, John G.; Keogh, Deborah A.; Weed, Keri

    This monograph details the Notre Dame Parenting Project, a comprehensive longitudinal study of the lives of adolescent mothers and their children from pregnancy through the first 8 years of life, describing how their respective developmental trajectories are interwoven and linked to the social contexts in which they live. A total of 281…

  5. Comparison of short-lived medical isotopes activation by laser thin target induced protons and conventional cyclotron proton beams

    NASA Astrophysics Data System (ADS)

    Murray, Joseph; Dudnikova, Galina; Liu, Tung-Chang; Papadopoulos, Dennis; Sagdeev, Roald; Su, J. J.; UMD MicroPET Team

    2014-10-01

    Production diagnostic or therapeutic nuclear medicines are either by nuclear reactors or by ion accelerators. In general, diagnostic nuclear radioisotopes have a very short half-life varying from tens of minutes for PET tracers and few hours for SPECT tracers. Thus supplies of PET and SPECT radiotracers are limited by regional production facilities. For example 18F-fluorodeoxyglucose (FDG) is the most desired tracer for positron emission tomography because its 110 minutes half-life is sufficient long for transport from production facilities to nearby users. From nuclear activation to completing image taking must be done within 4 hours. Decentralized production of diagnostic radioisotopes will be idea to make high specific activity radiotracers available to researches and clinicians. 11 C, 13 N, 15 O and 18 F can be produced in the energy range from 10-20 MeV by protons. Protons of energies up to tens of MeV generated by intense laser interacting with hydrogen containing targets have been demonstrated by many groups in the past decade. We use 2D PIC code for proton acceleration, Geant4 Monte Carlo code for nuclei activation to compare the yields and specific activities of short-lived isotopes produced by cyclotron proton beams and laser driven protons.

  6. Doing Well: A SEM Analysis of the Relationships between Various Activities of Daily Living and Geriatric Well-Being

    ERIC Educational Resources Information Center

    Katt, James A.; Speranza, Linda; Shore, Wendy; Saenz, Karen H.; Witta, E. Lea

    2009-01-01

    An existing large data set, the Health and Retirement Study (HRS) with the subsequent addition of the Consumption and Activities Mail Survey (CAMS) data, provides a rich data set for the examination of the activities of older adults. In this study HRS and CAMS data are used to examine relationships between various activities of daily living (ADLs)…

  7. Knowing and "Unknowing" Transnational Latino Lives in Teacher Education: At the Intersection of Educational Research and the Latino Humanities

    ERIC Educational Resources Information Center

    Villenas, Sofia A.

    2009-01-01

    Qualitative and ethnographic research in immigrant/Diaspora education has contributed significantly to prospective and practicing teachers' "unknowing" of Latino families as culturally deficient. Engagement with this scholarship in teacher education has opened the possibilities for a more complex knowing of Latino families' and youth's lives. With…

  8. Combining Qualitative and Quantitative Methodologies in Research on Teachers' Lives, Work, and Effectiveness: From Integration to Synergy

    ERIC Educational Resources Information Center

    Day, Christopher; Sammons, Pam; Gu, Qing

    2008-01-01

    The authors of this article discuss how a mixed-methods research team designed and conducted a 4-year study (Variations in Teachers' Work and Lives and Their Effects on Pupils) that tracked 300 teachers in 100 schools in England over a 3-year fieldwork period. The authors discuss processes that led to new knowledge. Although mixed methods are…

  9. Novel Bioluminescent Activatable Reporter for Src Tyrosine Kinase Activity in Living Mice

    PubMed Central

    Leng, Weibing; Li, Dezhi; Chen, Liang; Xia, Hongwei; Tang, Qiulin; Chen, Baoqin; Gong, Qiyong; Gao, Fabao; Bi, Feng

    2016-01-01

    Aberrant activation of the Src kinase is implicated in the development of a variety of human malignancies. However, it is almost impossible to monitor Src activity in an in vivo setting with current biochemical techniques. To facilitate the noninvasive investigation of the activity of Src kinase both in vitro and in vivo, we developed a genetically engineered, activatable bioluminescent reporter using split-luciferase complementation. The bioluminescence of this reporter can be used as a surrogate for Src activity in real time. This hybrid luciferase reporter was constructed by sandwiching a Src-dependent conformationally responsive unit (SH2 domain-Srcpep) between the split luciferase fragments. The complementation bioluminescence of this reporter was dependent on the Src activity status. In our study, Src kinase activity in cultured cells and tumor xenografts was monitored quantitatively and dynamically in response to clinical small-molecular kinase inhibitors, dasatinib and saracatinib. This system was also applied for high-throughput screening of Src inhibitors against a kinase inhibitor library in living cells. These results provide unique insights into drug development and pharmacokinetics/phoarmocodynamics of therapeutic drugs targeting Src signaling pathway enabling the optimization of drug administration schedules for maximum benefit. Using both Firefly and Renilla luciferase imaging, we have successfully monitored Src tyrosine kinase activity and Akt serine/threonine kinase activity concurrently in one tumor xenograft. This dual luciferase reporter imaging system will be helpful in exploring the complex signaling networks in vivo. The strategies reported here can also be extended to study and image other important kinases and the cross-talks among them. PMID:26941850

  10. Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay

    PubMed Central

    Haaß, Wiltrud; Kleiner, Helga; Müller, Martin C.; Hofmann, Wolf-Karsten; Fabarius, Alice; Seifarth, Wolfgang

    2015-01-01

    ESPL1/Separase, an endopeptidase, is required for centrosome duplication and separation of sister-chromatides in anaphase of mitosis. Overexpression and deregulated proteolytic activity of Separase as frequently observed in human cancers is associated with the occurrence of supernumerary centrosomes, chromosomal missegregation and aneuploidy. Recently, we have hypothesized that increased Separase proteolytic activity in a small subpopulation of tumor cells may serve as driver of tumor heterogeneity and clonal evolution in chronic myeloid leukemia (CML). Currently, there is no quantitative assay to measure Separase activity levels in single cells. Therefore, we have designed a flow cytometry-based assay that utilizes a Cy5- and rhodamine 110 (Rh110)-biconjugated Rad21 cleavage site peptide ([Cy5-D-R-E-I-M-R]2-Rh110) as smart probe and intracellular substrate for detection of Separase enzyme activity in living cells. As measured by Cy5 fluorescence the cellular uptake of the fluorogenic peptide was fast and reached saturation after 210 min of incubation in human histiocytic lymphoma U937 cells. Separase activity was recorded as the intensity of Rh110 fluorescence released after intracellular peptide cleavage providing a linear signal gain within a 90–180 min time slot. Compared to conventional cell extract-based methods the flow cytometric assay delivers equivalent results but is more reliable, bypasses the problem of vague loading controls and unspecific proteolysis associated with whole cell extracts. Especially suited for the investigaton of blood- and bone marrow-derived hematopoietic cells the flow cytometric Separase assay allows generation of Separase activity profiles that tell about the number of Separase positive cells within a sample i.e. cells that currently progress through mitosis and about the range of intercellular variation in Separase activity levels within a cell population. The assay was used to quantify Separase proteolytic activity in leukemic

  11. Does where you live matter? Leisure-time physical activity among Canadian youth: a multiple cross-sectional study

    PubMed Central

    Nadeau, Charles; Letarte, Laurence; Fratu, Ramona; Waygood, E. Owen D.; Lebel, Alexandre

    2016-01-01

    Background: The aim of this study was to explore the population-wide distribution in the practice of leisure-time physical activity among Canadian youth and how physical activity level is influenced by contextual features of the environment. Methods: We studied the self-reported leisure-time physical activity of 54 832 Canadians aged 12 to 17 years. Observations were structured according to a 4-level geographic hierarchy. The outcome studied was a dichotomous indicator that referred to achieving (or not) the recommended daily level of leisure-time physical activity. To investigate the influence of the contextual features, we conducted multilevel logistic regressions. Results: For both girls and boys, significant variations were observed between health regions and between neighbourhoods within the provinces. Girls who lived in an urban setting showed lower odds of achieving the recommended physical activity level, as did those surveyed during the winter. Boys surveyed during the winter also showed lower odds of achieving the recommended level, but living in an urban setting had no effect on activity levels. Analysis of province-level residuals showed that girls living in Quebec were less likely to achieve the recommended activity level as compared with the national mean, and girls living in Ontario and British Columbia were more likely to achieve that threshold. Boys living in Ontario were more likely to achieve the recommended activity level as compared with the national mean. Youth had up to a 17% increased chance of achieving the recommended physical activity level if they lived in a context with a higher activity achievement level. Interpretation: Leisure-time physical activity was associated with environmental factors at multiple geographic scales among Canadian youth. The variation was more important at the neighbourhood level. The results provide rationale for further investigation into how leisure-time physical activity is promoted in different contexts

  12. Beliefs about participating in research among a sample of minority persons living with HIV/AIDS in New York City.

    PubMed

    Floyd, Tiffany; Patel, Shilpa; Weiss, Elisa; Zaid-Muhammad, Soye; Lounsbury, David; Rapkin, Bruce

    2010-06-01

    Despite substantial data documenting the challenges in recruiting racial and ethnic minorities into research studies, relatively little is known about the attitudes and beliefs toward research that are held by racial and ethnic minorities living with HIV/AIDS. The present study assessed the research attitudes and beliefs of a racially and ethnically diverse group of persons living with HIV/AIDS, with research broadly defined as either psychosocial, behavioral, or clinical. Also assessed were factors that would encourage or discourage them from participating in a research study. Six hundred twenty-two participants were recruited from 22 points of service in New York City; data were gathered through a single in-person structured interview conducted in Spanish or English. Findings from a series of quantitative analyses indicated that attitudes about research were primarily neutral or positive, and different attitude and belief patterns were associated with different preferences regarding what would or would not incline one to participate in a research study. Results suggest that minorities with HIV/AIDS are open to the possibility participating in research; however, they also suggest that receptivity to research may not be uniform and indicated a variety of specific research design and implementation options that investigators should consider in order to ensure sufficient access and interest in participation.

  13. Breaking-up sedentary time is associated with impairment in activities of daily living.

    PubMed

    Sardinha, Luis B; Ekelund, Ulf; dos Santos, Leandro; Cyrino, Edilson S; Silva, Analiza M; Santos, Diana A

    2015-12-01

    Identifying modifiable behaviors associated with prevention of activities of daily living (ADL) impairments is vital to implement preventive strategies for independent living in elderly. We aimed to examine the associations between objectively measured breaks in sedentary time with ADL impairments and physical independence. Cross-sectional assessments were carried out in 371 participants (131 male) aged 65-103 years from the Portuguese surveillance system of physical activity. Physical activity (PA) and sedentary time (ST) were assessed with accelerometry, and ADL impairments and physical independence with the self-reported 12-item composite physical function scale. Using ROC analyses a cut-off of 7 hourly breaks in sedentary time was identified which maximized the sensitivity and specificity in diagnosing physical dependence. Logistic regression analysis demonstrated that, independently of moderate-to-vigorous PA (MVPA), participants performing ≤ 7 hourly breaks in sedentary time had 2 to 7 fold increased odds for impairment in 10 of the 12 ADL. When stratifying ADL into basic, instrumental and advanced ADL we verified that less than 7 hourly breaks in sedentary time was associated with a 2 to 5 fold increased odds for impairments and physical dependence, independent of MVPA. No associations were observed between meeting PA guidelines and basic, instrumental, and advanced ADL impairment although time in MVPA was lower in participants showing impairments. In conclusion, the frequency of breaks in sedentary time in older ages is independently associated with lower risk for ADL impairments and physical dependence. Our findings support interventions to encourage older adults to increase overall PA by interrupting sedentary time.

  14. Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat.

    PubMed

    Dziegelewska, Maja; Holtze, Susanne; Vole, Christiane; Wachter, Ulrich; Menzel, Uwe; Morhart, Michaela; Groth, Marco; Szafranski, Karol; Sahm, Arne; Sponholz, Christoph; Dammann, Philip; Huse, Klaus; Hildebrandt, Thomas; Platzer, Matthias

    2016-08-01

    Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration.

  15. The 'Technology - Activities of Daily Living Questionnaire': a version with a technology-related subscale

    PubMed Central

    Muñoz-Neira, Carlos; López, Oscar L.; Riveros, Rodrigo; Nuñez-Huasaf, Javier; Flores, Patricia; Slachevsky, Andrea

    2016-01-01

    Background Information and communication technology (ICT) has become an increasingly important part of daily life. The ability to use technology is becoming essential for autonomous functioning in society. Current functional scales for patients with cognitive impairment do not evaluate the use of technology. The objective of this study was to develop and validate a new version of the Activities of Daily Living Questionnaire (ADLQ) that incorporates an ICT subscale. Method A new technology-based subscale was incorporated into the Spanish Version of the ADLQ (SV-ADLQ), entitled The Technology Version of the ADLQ (T-ADLQ). The T-ADLQ was administered to 63 caregivers of dementia patients, 21 proxies of mild cognitive impairment patients and 44 proxies of normal elderly subjects (mean age of the sample ± SD: 73.5 ± 8.30). We analysed the convergent validity, internal consistency, reliability cut-off point, sensitivity and specificity of the T-ADLQ. The results of the T-ADLQ were compared to the SV-ADLQ. Results The T-ADLQ showed significant correlations with the Mini-mental Test (MMSE), the Frontal Assesment Battery (FAB) as well as other measures of functional impairment and dementia severity (MMSE: r = −0.70; FAB: r = −0.65; Functional Assessment Questionnaire: r = 0.77; Instrumental Activities of Daily Living Scale: r = −0.75; Clinical Dementia Rating Scale: r = 0.72; p<0.001). The T-ADLQ showed a good reliability with a relatively high Cronbach’s alpha coefficient (Cronbach’s alpha = 0.861). When considering a functional impairment cut-off point greater than 29.25%, the sensitivity and specificity of the T-ADLQ were 82% and 90%, respectively. The area under the ROC curve (AUC) was 0.937 for the T-ADLQ and 0.932 for the original version of the test. Conclusions The T-ADLQ revealed adequate indicators of validity and reliability for the functional assessment of activities of daily living in dementia patients. However, the inclusion of technology items in

  16. Disabilities and Activities of Daily Living Among Veterans With Old Hip Disarticulation and Transpelvic Amputation

    PubMed Central

    Kachooei, Amir Reza; Ebrahimzadeh, Mohamad Hosein; Hallaj Moghadam, Mohamad; Fattahi, Asieh-sadat; Razi, Shiva; Salehi, Maryam; Azema, Hasan

    2014-01-01

    Background: The Iran-Iraq imposed war lasted eight years and was one of the longest wars of the last century. Twenty-three years have passed since the war ended, but little has been discussed about the long-term results of war amputations in the literature. Objectives: In this long-term study, we have evaluated the activities of daily living among veterans with hip or hemipelvis amputations. Patients and Methods: A cross-sectional study was performed on Iran-Iraq war veterans with hip or hemipelvis amputations in Iran. Eighty-four (96.5%) veterans out of 87 registered veterans with hip or hemipelvis amputations participated in the study. The degree of independence for activities of daily living (ADL) was assessed by the Barthel index. The degree of independence for instrumental activities of daily living (IADL) was assessed by the Lawton-Brody scale. Results: The average follow-up time was 26.6 ± 3.7 years. The average age of veterans was 44.1±7 years old. Of 84 amputees, 57 (67.85%) had limitations in at least one domain of the ADL. The most common single item that affected the patients was ascending and descending stairs seen in 45 (78.9%) veterans, followed by eating seen in 4 (7.01%) veterans. In addition, 70 (83.33%) had limitations in at least one domain of the IADL. The most common single item that affected the veterans was shopping seen in 56 (80%), followed by responsibility for own medications seen in 13 (18.57%) veterans. Spearman correlation coefficient of the sum scores of ADL and IADL showed an intermediate to strong correlation (r = 0.58). Conclusions: Increasing dependency in ADL is accompanied by increasing dependency in IADL. In the past, the duty of health care providers was saving the life of veterans due to injuries while at present, because these injuries occurred in young and healthy individuals, the need for increased function is being highlighted. PMID:25032170

  17. [Frontiers in Live Bone Imaging Researches. In vivo imaging of osteoblasts].

    PubMed

    Furuya, Masayuki; Ishii, Masaru

    2015-06-01

    Osteoblasts are bone-forming cells and lately osteoblastic niche is getting a lot more attention as a candidate of hematopoietic niche. Although there have been many previous studies about osteoblasts, there are few studies about the dynamics of osteoblasts. Recent rapid advance of fluorescent imaging techniques enables us to observe cellular dynamics and there are some reports that osteoblasts were visualized in live bone by using intravital two-photon microscopy. Here we show past reports about live cell imaging of osteoblasts and our latest data of live cell imaging of osteoblasts in vivo and in vitro.

  18. Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering

    PubMed Central

    Hu, Fanghao; Lamprecht, Michael R.; Wei, Lu; Morrison, Barclay; Min, Wei

    2016-01-01

    Brain is an immensely complex system displaying dynamic and heterogeneous metabolic activities. Visualizing cellular metabolism of nucleic acids, proteins, and lipids in brain with chemical specificity has been a long-standing challenge. Recent development in metabolic labeling of small biomolecules allows the study of these metabolisms at the global level. However, these techniques generally require nonphysiological sample preparation for either destructive mass spectrometry imaging or secondary labeling with relatively bulky fluorescent labels. In this study, we have demonstrated bioorthogonal chemical imaging of DNA, RNA, protein and lipid metabolism in live rat brain hippocampal tissues by coupling stimulated Raman scattering microscopy with integrated deuterium and alkyne labeling. Heterogeneous metabolic incorporations for different molecular species and neurogenesis with newly-incorporated DNA were observed in the dentate gyrus of hippocampus at the single cell level. We further applied this platform to study metabolic responses to traumatic brain injury in hippocampal slice cultures, and observed marked upregulation of protein and lipid metabolism particularly in the hilus region of the hippocampus within days of mechanical injury. Thus, our method paves the way for the study of complex metabolic profiles in live brain tissue under both physiological and pathological conditions with single-cell resolution and minimal perturbation. PMID:28000773

  19. The coelacanth: Can a “living fossil” have active transposable elements in its genome?

    PubMed Central

    Naville, Magali; Chalopin, Domitille; Casane, Didier; Laurenti, Patrick; Volff, Jean-Nicolas

    2015-01-01

    The coelacanth has long been regarded as a “living fossil,” with extant specimens looking very similar to fossils dating back to the Cretaceous period. The hypothesis of a slowly or even not evolving genome has been proposed to account for this apparent morphological stasis. While this assumption seems to be sustained by different evolutionary analyses on protein-coding genes, recent studies on transposable elements have provided more conflicting results. Indeed, the coelacanth genome contains many transposable elements and has been shaped by several major bursts of transposition during evolution. In addition, comparison of orthologous genomic regions from the genomes of the 2 extant coelacanth species L. chalumnae and L. menadoensis revealed multiple species-specific insertions, indicating transposable element recent activity and contribution to post-speciation genome divergence. These observations, which do not support the genome stasis hypothesis, challenge either the impact of transposable elements on organismal evolution or the status of the coelacanth as a “living fossil.” Closer inspection of fossil and molecular data indicate that, even if coelacanths might evolve more slowly than some other lineages due to demographic and/or ecological factors, this variation is still in the range of a “non-fossil” vertebrate species. PMID:26442185

  20. Linking Existing Instruments to Develop an Activity of Daily Living Item Bank.

    PubMed

    Li, Chih-Ying; Romero, Sergio; Bonilha, Heather S; Simpson, Kit N; Simpson, Annie N; Hong, Ickpyo; Velozo, Craig A

    2016-11-16

    This study examined dimensionality and item-level psychometric properties of an item bank measuring activities of daily living (ADL) across inpatient rehabilitation facilities and community living centers. Common person equating method was used in the retrospective veterans data set. This study examined dimensionality, model fit, local independence, and monotonicity using factor analyses and fit statistics, principal component analysis (PCA), and differential item functioning (DIF) using Rasch analysis. Following the elimination of invalid data, 371 veterans who completed both the Functional Independence Measure (FIM) and minimum data set (MDS) within 6 days were retained. The FIM-MDS item bank demonstrated good internal consistency (Cronbach's α = .98) and met three rating scale diagnostic criteria and three of the four model fit statistics (comparative fit index/Tucker-Lewis index = 0.98, root mean square error of approximation = 0.14, and standardized root mean residual = 0.07). PCA of Rasch residuals showed the item bank explained 94.2% variance. The item bank covered the range of θ from -1.50 to 1.26 (item), -3.57 to 4.21 (person) with person strata of 6.3. The findings indicated the ADL physical function item bank constructed from FIM and MDS measured a single latent trait with overall acceptable item-level psychometric properties, suggesting that it is an appropriate source for developing efficient test forms such as short forms and computerized adaptive tests.

  1. The coelacanth: Can a "living fossil" have active transposable elements in its genome?

    PubMed

    Naville, Magali; Chalopin, Domitille; Casane, Didier; Laurenti, Patrick; Volff, Jean-Nicolas

    2015-01-01

    The coelacanth has long been regarded as a "living fossil," with extant specimens looking very similar to fossils dating back to the Cretaceous period. The hypothesis of a slowly or even not evolving genome has been proposed to account for this apparent morphological stasis. While this assumption seems to be sustained by different evolutionary analyses on protein-coding genes, recent studies on transposable elements have provided more conflicting results. Indeed, the coelacanth genome contains many transposable elements and has been shaped by several major bursts of transposition during evolution. In addition, comparison of orthologous genomic regions from the genomes of the 2 extant coelacanth species L. chalumnae and L. menadoensis revealed multiple species-specific insertions, indicating transposable element recent activity and contribution to post-speciation genome divergence. These observations, which do not support the genome stasis hypothesis, challenge either the impact of transposable elements on organismal evolution or the status of the coelacanth as a "living fossil." Closer inspection of fossil and molecular data indicate that, even if coelacanths might evolve more slowly than some other lineages due to demographic and/or ecological factors, this variation is still in the range of a "non-fossil" vertebrate species.

  2. Efficient selective breeding of live oil-rich Euglena gracilis with fluorescence-activated cell sorting.

    PubMed

    Yamada, Koji; Suzuki, Hideyuki; Takeuchi, Takuto; Kazama, Yusuke; Mitra, Sharbanee; Abe, Tomoko; Goda, Keisuke; Suzuki, Kengo; Iwata, Osamu

    2016-05-23

    Euglena gracilis, a microalgal species of unicellular flagellate protists, has attracted much attention in both the industrial and academic sectors due to recent advances in the mass cultivation of E. gracilis that have enabled the cost-effective production of nutritional food and cosmetic commodities. In addition, it is known to produce paramylon (β-1,3-glucan in a crystalline form) as reserve polysaccharide and convert it to wax ester in hypoxic and anaerobic conditions-a promising feedstock for biodiesel and aviation biofuel. However, there remain a number of technical challenges to be solved before it can be deployed in the competitive fuel market. Here we present a method for efficient selective breeding of live oil-rich E. gracilis with fluorescence-activated cell sorting (FACS). Specifically, the selective breeding method is a repetitive procedure for one-week heterotrophic cultivation, staining intracellular lipids with BODIPY(505/515), and FACS-based isolation of top 0.5% lipid-rich E. gracilis cells with high viability, after inducing mutation with Fe-ion irradiation to the wild type (WT). Consequently, we acquire a live, stable, lipid-rich E. gracilis mutant strain, named B1ZFeL, with 40% more lipid content on average than the WT. Our method paves the way for rapid, cost-effective, energy-efficient production of biofuel.

  3. Efficient selective breeding of live oil-rich Euglena gracilis with fluorescence-activated cell sorting

    PubMed Central

    Yamada, Koji; Suzuki, Hideyuki; Takeuchi, Takuto; Kazama, Yusuke; Mitra, Sharbanee; Abe, Tomoko; Goda, Keisuke; Suzuki, Kengo; Iwata, Osamu

    2016-01-01

    Euglena gracilis, a microalgal species of unicellular flagellate protists, has attracted much attention in both the industrial and academic sectors due to recent advances in the mass cultivation of E. gracilis that have enabled the cost-effective production of nutritional food and cosmetic commodities. In addition, it is known to produce paramylon (β-1,3-glucan in a crystalline form) as reserve polysaccharide and convert it to wax ester in hypoxic and anaerobic conditions–a promising feedstock for biodiesel and aviation biofuel. However, there remain a number of technical challenges to be solved before it can be deployed in the competitive fuel market. Here we present a method for efficient selective breeding of live oil-rich E. gracilis with fluorescence-activated cell sorting (FACS). Specifically, the selective breeding method is a repetitive procedure for one-week heterotrophic cultivation, staining intracellular lipids with BODIPY505/515, and FACS-based isolation of top 0.5% lipid-rich E. gracilis cells with high viability, after inducing mutation with Fe-ion irradiation to the wild type (WT). Consequently, we acquire a live, stable, lipid-rich E. gracilis mutant strain, named B1ZFeL, with 40% more lipid content on average than the WT. Our method paves the way for rapid, cost-effective, energy-efficient production of biofuel. PMID:27212384

  4. [Behavioral competence among community dwelling older people with disability in basic activities of daily living].

    PubMed

    Ishizaki, T; Watanabe, S; Suzuki, T; Shibata, H; Yoshida, H; Yasumura, S; Niino, N

    2000-07-01

    This study observed the status of independence in behavioral competence among older people who have any disability in basic activities of daily living (BADL) living in a rural community in Japan. Study participants (N = 76) who were regarded as bedridden were surveyed by means of a questionnaire in July to August 1996. The independence variables were age, sex, BADL status, hearing impairment, visual impairment, history of stroke, and cognitive impairment. The dependent variable was each item of the Tokyo Metropolitan Institute of Gerontology (TMIG) Index of Competence, which is a multidimensional 13-item index of behavioral competence. Percentages of subjects who were independent in each item of the TMIG Index of Competence varied from 1% to 36%. Multiple logistic regression analyses revealed that BADL status was independently associated with independence in using a telephone, being interested in news stories or programs dealing with health, being called on for advice, and initiating conversations with young people, after adjustment for age, sex, hearing impairment, visual impairment, history of stroke, and cognitive impairment. These findings suggest that programs for preventing decline in behavioral competence of older people with BADL disability might be important as well as physical therapy for them.

  5. Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering

    NASA Astrophysics Data System (ADS)

    Hu, Fanghao; Lamprecht, Michael R.; Wei, Lu; Morrison, Barclay; Min, Wei

    2016-12-01

    Brain is an immensely complex system displaying dynamic and heterogeneous metabolic activities. Visualizing cellular metabolism of nucleic acids, proteins, and lipids in brain with chemical specificity has been a long-standing challenge. Recent development in metabolic labeling of small biomolecules allows the study of these metabolisms at the global level. However, these techniques generally require nonphysiological sample preparation for either destructive mass spectrometry imaging or secondary labeling with relatively bulky fluorescent labels. In this study, we have demonstrated bioorthogonal chemical imaging of DNA, RNA, protein and lipid metabolism in live rat brain hippocampal tissues by coupling stimulated Raman scattering microscopy with integrated deuterium and alkyne labeling. Heterogeneous metabolic incorporations for different molecular species and neurogenesis with newly-incorporated DNA were observed in the dentate gyrus of hippocampus at the single cell level. We further applied this platform to study metabolic responses to traumatic brain injury in hippocampal slice cultures, and observed marked upregulation of protein and lipid metabolism particularly in the hilus region of the hippocampus within days of mechanical injury. Thus, our method paves the way for the study of complex metabolic profiles in live brain tissue under both physiological and pathological conditions with single-cell resolution and minimal perturbation.

  6. Living with a Star: New Opportunities in Sun-Climate Research

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Living With a Star is a NASA initiative employing the combination of dedicated spacecraft with targeted research and modeling efforts to improve what we know of solar effects of all kinds on the Earth and its surrounding space environment, with particular emphasis on those that have significant practical impacts on life and society. The highest priority among these concerns is the subject of this report: the potential effects of solar variability on regional and global climate, including the extent to which solar variability has contributed to the well-documented warming of the Earth in the last 100 years. Understanding how the climate system reacts to external forcing from the Sun will also greatly improve our knowledge of how climate will respond to other climate drivers, including those of anthropogenic origin. A parallel element of the LWS program addresses solar effects on space weather : the impulsive emissions of charged particles, short-wave electromagnetic radiation and magnetic disturbances in the upper atmosphere and near-Earth environment that also affect life and society. These include a wide variety of solar impacts on aeronautics, astronautics, electric power transmission, and national defense. Specific examples are (1) the impacts of potentially- damaging high energy radiation and atomic particles of solar origin on satellites and satellite operations, spacecraft electronics systems and components, electronic communications, electric power distribution grids, navigational and GPS systems, and high altitude aircraft; and (2) the threat of sporadic, high-energy solar radiation to astronauts and high altitude aircraft passengers and crews. Elements of the LWS program include an array of dedicated spacecraft in near- Earth and near-Sun orbits that will closely study and observe both the Sun itself and the impacts of its variations on the Earth's radiation belts and magnetosphere, the upper atmosphere, and ionosphere. These spacecraft, positioned to

  7. The Role of the Kink Instability of a Long-Lived Active Region AR 9604

    NASA Astrophysics Data System (ADS)

    Tian, Lirong; Liu, Yang; Yang, Jing; Alexander, David

    2005-07-01

    We have traced the long-term evolution of a non-Hale active region composed of NOAA 9604 9632 9672 9704 9738, which displayed strong transient activity with associated geomagnetic effects from September to December, 2001. By studying the development of spot-group and line-of-sight magnetic field together with the evolution of Hα filaments, the EUV and X-ray corona (TRACE 171 Å, Yohkoh/SXT), we have found that the magnetic structure of the active region exhibited a continuous clockwise rotation throughout its entire life. Vector magnetic data obtained from Huairou Solar Observing Station (HSOS) and full-disk line-of-sight magnetograms from SOHO/MDI allowed the determination of the best-fit force-free parameter (proxy of twist), αbest, and the systematic tilt angle (proxy of writhe) which were both found to take positive values. Soft X-ray coronal loops from Yohkoh/SXT displayed a pronounced forward-sigmoid structure in period of NOAA 9704. These observations imply that the magnetic flux tube (loops) with the same handedness (right) of the writhe and the twist rotated clockwise in the solar atmosphere for a long time. We argue that the continuous clockwise rotation of the long-lived active region may be a manifestation that a highly right-hand twisted and kinked flux tube was emerging through the photosphere and chromosphere into the corona.

  8. Active in-database processing to support ambient assisted living systems.

    PubMed

    de Morais, Wagner O; Lundström, Jens; Wickström, Nicholas

    2014-08-12

    As an alternative to the existing software architectures that underpin the development of smart homes and ambient assisted living (AAL) systems, this work presents a database-centric architecture that takes advantage of active databases and in-database processing. Current platforms supporting AAL systems use database management systems (DBMSs) exclusively for data storage. Active databases employ database triggers to detect and react to events taking place inside or outside of the database. DBMSs can be extended with stored procedures and functions that enable in-database processing. This means that the data processing is integrated and performed within the DBMS. The feasibility and flexibility of the proposed approach were demonstrated with the implementation of three distinct AAL services. The active database was used to detect bed-exits and to discover common room transitions and deviations during the night. In-database machine learning methods were used to model early night behaviors. Consequently, active in-database processing avoids transferring sensitive data outside the database, and this improves performance, security and privacy. Furthermore, centralizing the computation into the DBMS facilitates code reuse, adaptation and maintenance. These are important system properties that take into account the evolving heterogeneity of users, their needs and the devices that are characteristic of smart homes and AAL systems. Therefore, DBMSs can provide capabilities to address requirements for scalability, security, privacy, dependability and personalization in applications of smart environments in healthcare.

  9. Diversity and methane oxidation of active epibiotic methanotrophs on live Shinkaia crosnieri

    PubMed Central

    Watsuji, Tomo-o; Yamamoto, Asami; Takaki, Yoshihiro; Ueda, Kenji; Kawagucci, Shinsuke; Takai, Ken

    2014-01-01

    Shinkaia crosnieri is a galatheid crab that predominantly dwells in deep-sea hydrothermal systems in the Okinawa Trough, Japan. In this study, the phylogenetic diversity of active methanotrophs in the epibiotic microbial community on the setae of S. crosnieri was characterized by reverse transcription-polymerase chain reaction (RT-PCR) of a functional gene (pmoA) encoding a subunit of particulate methane monooxygenase. Phylogenetic analysis of pmoA transcript sequences revealed that the active epibiotic methanotrophs on S. crosnieri setae consisted of gammaproteobacterial type Ia and Ib methanotrophs. The effect of different RNA stabilization procedures on the abundance of pmoA and 16S rRNA transcripts in the epibiotic community was estimated by quantitative RT-PCR. Our novel RNA fixation method performed immediately after sampling effectively preserved cellular RNA assemblages, particularly labile mRNA populations, including pmoA mRNA. Methane consumption in live S. crosnieri was also estimated by continuous-flow incubation under atmospheric and in situ hydrostatic pressures, and provided a clear evidence of methane oxidation activity of the epibiotic microbial community, which was not significantly affected by hydrostatic pressure. Our study revealed the significant ecological function and nutritional contribution of epibiotic methanotrophs to the predominant S. crosnieri populations in the Okinawa Trough deep-sea hydrothermal systems. In conclusion, our study gave clear facts about diversity and methane oxidation of active methanotrophs in the epibiotic community associated with invertebrates. PMID:24401859

  10. Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells

    PubMed Central

    Dong, Min; Tepp, William H.; Johnson, Eric A.; Chapman, Edwin R.

    2004-01-01

    Botulinum neurotoxins (BoNTs) act as zinc-dependent endopeptidases that cleave proteins required for neurotransmitter release. To detect toxin activity, fragments of the toxin substrate proteins, synaptobrevin (Syb) or synaptosome-associated protein of 25 kDa (SNAP-25), were used to link cyan fluorescent protein (CFP) to yellow fluorescent protein (YFP). Cleavage of these fusion proteins by BoNTs abolished fluorescence resonance energy transfer between the CFP and YFP, providing a sensitive means to detect toxin activity in real-time in vitro. Furthermore, using full-length SNAP-25 and Syb as the linkers, we report two fluorescent biosensors that can detect toxin activity within living cells. Cleavage of the SNAP-25 fusion protein abolished fluorescence resonance energy transfer between CFP and YFP, and cleavage of Syb resulted in spatial redistribution of YFP fluorescence in cells. This approach provides a means to carry out cell-based screening of toxin inhibitors and to study toxin activity in situ. By using these biosensors, we found that the subcellular localizations of SNAP-25 and Syb are critical for efficient cleavage by BoNT/A and B, respectively. PMID:15465919

  11. Persistent synchronized oscillations in prolactin gene promoter activity in living pituitary cells.

    PubMed

    McFerran, D W; Stirland, J A; Norris, A J; Khan, R A; Takasuka, N; Seymour, Z C; Gill, M S; Robertson, W R; Loudon, A S; Davis, J R; White, M R

    2001-07-01

    PRL gene expression in the anterior pituitary gland responds rapidly to different hormonal signals. We have investigated the long-term timing of transcriptional activation from the PRL, GH, and cytomegalovirus promoters in response to different stimulus duration, using real-time imaging of luciferase expression in living stably transfected GH3 cells. Long-term stimulation of serum-starved cells with 50% serum induced a homogeneous rise in PRL promoter activity, with subsequent heterogeneous fluctuations in luciferase activity in individual cells. When cells were subjected to a 2-h pulse of 50% serum, followed by serum-free medium, there were long-term (approximately 50 h) synchronized, homogeneous oscillations in PRL promoter activity. This response was PRL-specific, because in GH3 cells expressing luciferase from the GH or cytomegalovirus promoters, a serum pulse elicited no oscillations in luciferase expression after an initial transient response to serum. The PRL promoter may therefore be a template for an unstable transcription complex subject to stochastic regulation, allowing an oscillatory transcriptional response to physiological signals. This suggests that precise timing and coordination of cell responses to different signal-duration may represent a novel mechanism for coordinating long-term dynamic changes in transcription in cell populations.

  12. Physical activity and fracture risk in a free-living elderly cohort.

    PubMed

    Sorock, G S; Bush, T L; Golden, A L; Fried, L P; Breuer, B; Hale, W E

    1988-09-01

    A prospective study to determine if regular leisure-time physical activity (including recreational walking) is associated with fracture risk was conducted in a large cohort (N = 3110) of free-living elderly men and women in the retirement community of Dunedin, Florida. Sixty-three percent of the cohort was female, all were white, and the average age was 73.0 years +/- 5.3 (SD). Participants in regular physical activity at baseline had a reduced risk of fracture; the risk ratio (RR) of fracture for men and women, respectively, was RR = 0.41, 95% CI = 0.17 to 1.01 and RR = 0.76, 95% CI = 0.50 to 1.15. Walking at least one mile 3 times/week appeared to offer a protective effect for both sexes. After controlling for potentially confounding variables including body mass and selected health conditions, the RR for regular physical activity on fracture incidence in men and women remained essentially unchanged. We conclude that regular physical activity such as walking may protect against fracture in older persons.

  13. Active In-Database Processing to Support Ambient Assisted Living Systems

    PubMed Central

    de Morais, Wagner O.; Lundström, Jens; Wickström, Nicholas

    2014-01-01

    As an alternative to the existing software architectures that underpin the development of smart homes and ambient assisted living (AAL) systems, this work presents a database-centric architecture that takes advantage of active databases and in-database processing. Current platforms supporting AAL systems use database management systems (DBMSs) exclusively for data storage. Active databases employ database triggers to detect and react to events taking place inside or outside of the database. DBMSs can be extended with stored procedures and functions that enable in-database processing. This means that the data processing is integrated and performed within the DBMS. The feasibility and flexibility of the proposed approach were demonstrated with the implementation of three distinct AAL services. The active database was used to detect bed-exits and to discover common room transitions and deviations during the night. In-database machine learning methods were used to model early night behaviors. Consequently, active in-database processing avoids transferring sensitive data outside the database, and this improves performance, security and privacy. Furthermore, centralizing the computation into the DBMS facilitates code reuse, adaptation and maintenance. These are important system properties that take into account the evolving heterogeneity of users, their needs and the devices that are characteristic of smart homes and AAL systems. Therefore, DBMSs can provide capabilities to address requirements for scalability, security, privacy, dependability and personalization in applications of smart environments in healthcare. PMID:25120164

  14. Supporting the Social Lives of Adolescents Who Are Blind: Research to Practice

    ERIC Educational Resources Information Center

    Arndt, Katrina; Lieberman, Lauren; James, Alisa

    2014-01-01

    Seven adolescents who are blind and seven of their parents were interviewed about the adolescents' social lives. Adolescent and parent perspectives are reviewed, followed by implications for teachers to support the social connections of students who are blind.

  15. Summary of Chernobyl followup research activities

    SciTech Connect

    Not Available

    1992-06-01

    In NUREG-1251, ``Implications of the Accident at Chernobyl for Safety Regulation of Commercial Nuclear Power Plants in the United States,`` April 1989, the NRC staff concluded that no immediate changes in NRC`s regulations regarding design or operation of US commercial reactors were needed; however, it recommended that certain issues be considered further. NRC`s Chernobyl followup research program consisted of the research tasks undertaken in response to the recommendations in NUREG-1251. It included 23 tasks that addressed potential lessons to be learned from the Chernobyl accident. This report presents summaries of NRC`s Chernobyl followup research tasks. For each task, the Chernobyl-related issues are indicated, the work is described, and the staff`s findings and conclusions are presented. More detailed reports concerning the work are referenced where applicable. This report closes out NRC`s Chernobyl followup research program as such, but additional research will be conducted on some issues as needed. The report includes remarks concerning significant further activity with respect to the issues addressed.

  16. Summary of Chernobyl followup research activities

    SciTech Connect

    Not Available

    1992-06-01

    In NUREG-1251, Implications of the Accident at Chernobyl for Safety Regulation of Commercial Nuclear Power Plants in the United States,'' April 1989, the NRC staff concluded that no immediate changes in NRC's regulations regarding design or operation of US commercial reactors were needed; however, it recommended that certain issues be considered further. NRC's Chernobyl followup research program consisted of the research tasks undertaken in response to the recommendations in NUREG-1251. It included 23 tasks that addressed potential lessons to be learned from the Chernobyl accident. This report presents summaries of NRC's Chernobyl followup research tasks. For each task, the Chernobyl-related issues are indicated, the work is described, and the staff's findings and conclusions are presented. More detailed reports concerning the work are referenced where applicable. This report closes out NRC's Chernobyl followup research program as such, but additional research will be conducted on some issues as needed. The report includes remarks concerning significant further activity with respect to the issues addressed.

  17. Object Perception Impairments Predict Instrumental Activities of Daily Living Dependence in Alzheimer's Disease

    PubMed Central

    JEFFERSON, ANGELA L.; BARAKAT, LAMIA P.; GIOVANNETTI, TANIA; PAUL, ROBERT H.; GLOSSER, GUILA

    2009-01-01

    This study examined the contribution of object perception and spatial localization to functional dependence among Alzheimer's disease (AD) patients. Forty patients with probable AD completed measures assessing verbal recognition memory, working memory, object perception, spatial localization, semantic knowledge, and global cognition. Primary caregivers completed a measure of activities of daily living (ADLs) that included instrumental and basic self-care subscales (i.e., IADLs and BADLs, respectively). Stepwise multiple regressions revealed that global cognition accounted for significant portions of variance among the ADL total, IADL, and BADL scores. However, when global cognition was removed from the model, object perception was the only significant cognitive predictor of the ADL total and IADL subscale scores, accounting for 18.5% and 19.3% of the variance, respectively. When considering multiple cognitive components simultaneously, object perception and the integrity of the inferotemporal cortex is important in the completion of functional abilities in general and IADLs in particular among AD patients. PMID:16822730

  18. Attentional deficits affect activities of daily living in dementia‐associated with Parkinson's disease

    PubMed Central

    Bronnick, K; Ehrt, U; Emre, M; De Deyn, P P; Wesnes, K; Tekin, S; Aarsland, D

    2006-01-01

    Objective To investigate the effects of attentional deficits on activities of daily living (ADL) in patients with dementia associated with Parkinson's disease (PDD). Method 461 patients were assessed neuropsychologically. Factor analyses were used to differentiate attention from other cognitive functions and to differentiate different aspects of ADL functions. The effects of the attentional measure on ADL were examined using sequential multiple regression, controlling for age, sex, education, severity of motor symptoms and other cognitive functions. Results Three cognitive factors were identified, with one factor emerging as a measure of vigilance and focused attention. This factor predicted different aspects of ADL status even after controlling for motor functions and other cognitive factors. The attention factor was the single strongest cognitive predictor of ADL status, matching the strength of the effects of motor functions on ADL status. Conclusion Impaired attention is an important determinant of ADL functions in patients with PDD. PMID:16801351

  19. SVM-based multimodal classification of activities of daily living in Health Smart Homes: sensors, algorithms, and first experimental results.

    PubMed

    Fleury, Anthony; Vacher, Michel; Noury, Norbert

    2010-03-01

    By 2050, about one third of the French population will be over 65. Our laboratory's current research focuses on the monitoring of elderly people at home, to detect a loss of autonomy as early as possible. Our aim is to quantify criteria such as the international activities of daily living (ADL) or the French Autonomie Gerontologie Groupes Iso-Ressources (AGGIR) scales, by automatically classifying the different ADL performed by the subject during the day. A Health Smart Home is used for this. Our Health Smart Home includes, in a real flat, infrared presence sensors (location), door contacts (to control the use of some facilities), temperature and hygrometry sensor in the bathroom, and microphones (sound classification and speech recognition). A wearable kinematic sensor also informs postural transitions (using pattern recognition) and walk periods (frequency analysis). This data collected from the various sensors are then used to classify each temporal frame into one of the ADL that was previously acquired (seven activities: hygiene, toilet use, eating, resting, sleeping, communication, and dressing/undressing). This is done using support vector machines. We performed a 1-h experimentation with 13 young and healthy subjects to determine the models of the different activities, and then we tested the classification algorithm (cross validation) with real data.

  20. Spatio-temporal imaging of EGF-induced activation of protein kinase A by FRET in living cells

    NASA Astrophysics Data System (ADS)

    Wang, Jin Jun; Chen, Xiao-Chuan; Xing, Da

    2004-07-01

    Intracellular molecular interaction is important for the study of cell physiology, yet current relevant methods require fixation or microinjection and lack temporal or spatial resolution. We introduced a new method -- fluorescence resonance energy transfer (FRET) to detect molecular interaction in living cells. On the basis of FRET principle, A-kinase activity reporter (AKAR) protein was designed to consist of the fusions of cyan fluorescent protein (CFP), a phosphoamino acid binding domain, a consensus substrate for protein kinase-A (PKA), and yellow fluorescent protein (YFP). In this study, the designed pAKAR plasmid was used to transfect a human lung cancer cell line (ASTC-a-1). When the AKAR-transfected cells were treated by forskolin (Fsk), we were able to observe the efficient transfer of energy from excited CFP to YFP within the AKAR molecule by fluorescence microcopy, whereas no FRET was detected in the transfected cells without the treatment of Fsk. When the cells were treated by Epidermal growth factor (EGF), the change of FRET was observed at different subcellular locations, reflecting PKA activation inside the cells upon EGF stimulation. The successful design of a fluorescence reporter of PKA activation and its application demonstrated the superiority of this technology in the research of intracellular protein-protein interaction.

  1. Daily life in very old age: everyday activities as expression of successful living.

    PubMed

    Horgas, A L; Wilms, H U; Baltes, M M

    1998-10-01

    The goals of this article are (a) to describe the daily life of the very old in terms of frequency, duration, variety, and social and physical contexts of activities, and (b) to examine the effects of background variables (e.g., age, sex, residential and marital status, income, and education) on late life activity engagement. A representative sample of 516 adults aged 70-105 was interviewed about their activities using the Yesterday Interview. In contrast to most research on activity engagement, this measurement approach allows for assessment of both the type and context of activities engaged in during the day preceding the interview. The results indicated high frequencies of obligatory activities but also showed substantial time spent in discretionary activities, with television viewing occupying most of the participants' leisure time. Most activities were done alone and at home. In bivariate and multiple regression analyses, age and residential status had the strongest association with activity frequency, duration, and variety; the oldest-old and those residing in long-term care facilities had lower levels of activity engagement. Results are discussed in terms of their relevance for successful aging.

  2. Associations between active living-oriented zoning and no adult leisure-time physical activity in the U.S.

    PubMed

    Leider, Julien; Chriqui, Jamie F; Thrun, Emily

    2017-02-01

    Nearly one-third of adults report no leisure-time physical activity (LTPA). Governmental and authoritative bodies recognize the role that community design through zoning code changes can play in enabling LTPA. This study examined the association between zoning and no adult LTPA in the U.S. This study was conducted between 2012 and 2016, with analyses occurring in 2015-2016. Zoning codes effective as of 2010 were compiled for jurisdictions located in the 495 most populous U.S. counties and were evaluated for pedestrian-oriented code reform zoning, 11 active living-oriented provisions (e.g., sidewalks, bike-pedestrian connectivity, mixed use, bike lanes) and a summated zoning scale (max=12). Individual-level LTPA data were obtained from the 2012 CDC Behavioral Risk Factor Surveillance System (BRFSS). County-aggregated, population-weighted zoning variables were constructed for linking to BRFSS. Log-log multivariate regressions (N=147,517 adults), controlling for individual and county characteristics and with robust standard errors clustered on county, were conducted to examine associations between zoning and no LTPA. Relative risks (RR) compared predicted lack of LTPA at 0% and 100% county-level population exposure to each zoning predictor. Zoning code reforms were associated with a 13% lower probability of no LTPA (RR: 0.87, 95% CI: 0.82-0.92). Except for crosswalks, all zoning provisions were associated with an 11-16% lower probability of no LTPA. Having all 12 zoning provisions was associated with a 22% lower probability of no LTPA (RR: 0.78, 95% CI: 0.72-0.83). The results suggest that active living-oriented zoning is a policy lever available to communities seeking to reduce rates of no LTPA.

  3. Relationship Between Grip and Pinch Strength and Activities of Daily Living in Stroke Patients

    PubMed Central

    Bae, Jung Hyun; Seo, Kyung Mook; Kim, Don-Kyu; Shin, Hyun Iee; Shin, Hye Eun

    2015-01-01

    Objective To investigate the relationship between grip and pinch strength and independence in activities of daily living (ADL) in stroke patients. Methods Medical records of 577 stroke patients from January 2010 to February 2013 were retrospectively reviewed. Patients' grip and pinch strength of both hemiplegic and non-hemiplegic hands and the Korean version of Modified Barthel Index (K-MBI) score were collected. These patients were divided into three groups: group A (onset duration: ≤3 months), group B (onset duration: >3 months and <2 years), and group C (onset duration: ≥2 years). The correlation between grip and pinch strength and the K-MBI score was analyzed. Results In group A (95 patients), the K-MBI score was significantly (p<0.05) correlated with the grip and pinch strength of both hands in patients with right hemiplegia. Significant (p<0.05) correlation between the K-MBI score and the grip and pinch strength of the hemiplegic hand was shown in patients with left hemiplegia. In group B (69 patients) and group C (73 patients), the K-MBI score was significantly (p<0.05) correlated with the grip and pinch strength of the hemiplegic hand. Conclusion Stroke patients in subacute stage mainly performed activities of daily living using their dominant hand. However, independence in ADL was associated with the strength of the affected dominant hand. For stroke patients in chronic and late chronic stages, their hand power of the affected hand was associated with independence in ADL regardless whether the dominant hand was affected. PMID:26605173

  4. Association Between Social Participation and Instrumental Activities of Daily Living Among Community-Dwelling Older Adults

    PubMed Central

    Tomioka, Kimiko; Kurumatani, Norio; Hosoi, Hiroshi

    2016-01-01

    Background Population-based data examining the relationship between social participation (SP) and instrumental activities of daily living (IADL) are scarce. This study examined the cross-sectional relationship between SP and IADL in community-dwelling elderly persons. Methods Self-administered questionnaires were mailed to 23 710 residents aged ≥65 years in Nara, Japan (response rate: 74.2%). Data from 14 956 respondents (6935 males and 8021 females) without dependency in basic activities of daily living (ADL) were analyzed. The number, type, and frequency of participation in social groups (SGs) were used to measure SP. SGs included volunteer groups, sports groups, hobby groups, senior citizens’ clubs, neighborhood community associations, and cultural groups. IADL was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Logistic regression models stratified by gender were used. Results After adjustment for putative confounding factors, including demographics, health status, life-style habits, ADL, depression, cognitive function, social networks, social support, and social roles, participation in various SGs among both genders was inversely associated with poor IADL, showing a significant dose-response relationship between an increasing number of SGs and a lower proportion of those with poor IADL (P for trend <0.001). A significant inverse association between frequent participation and poor IADL was observed for all types of SGs among females, whereas the association was limited to sports groups and senior citizens’ clubs among males. Conclusions Our results show that participation in a variety of SGs is associated with independent IADL among the community-dwelling elderly, regardless of gender. However, the beneficial effects of frequent participation on IADL may be stronger for females than for males. PMID:27180933

  5. Concurrent Validity of Wearable Activity Trackers Under Free-Living Conditions.

    PubMed

    Brooke, Skyler M; An, Hyun-Sung; Kang, Seoung-Ki; Noble, John M; Berg, Kris E; Lee, Jung-Min

    2017-04-01

    Brooke, SM, An, H-S, Kang, S-K, Noble, JM, Berg, KE, and Lee, J-M. Concurrent validity of wearable activity trackers under free-living conditions. J Strength Cond Res 31(4): 1097-1106, 2017-The purpose of this study is to evaluate the concurrent validity of wearable activity trackers in energy expenditure (EE) and sleep period time (SPT) under free-living conditions. Ninety-five (28.5 ± 9.8 years) healthy men (n = 34) and women (n = 61) participated in this study. The total EE and SPT were measured using 8 monitors: Nike+ FuelBand SE (NFB), Garmin VivoFit (VF), Misfit Shine (MF), Fitbit Flex (FF), Jawbone UP (JU), Polar Loop (PL), Fitbit Charge HR (FC), and SenseWear Armband Mini (SWA) (criterion measures: SWA for EE and a sleep log for SPT). The mean absolute percent error (MAPE) for EE was 13.0, 15.2, 15.5, 16.1, 16.2, 22.8, and 24.5% for PL, MF, FF, NFB, FC, JU, and VF, respectively. Mean absolute percent errors were calculated for SPT to be 4.0, 8.8, 10.2, 11.5, 12.9, 13.6, 17.5, and 21.61% for VF, FF, JU, FC, MF, SWA laying down, PL, and SWA, respectively. Concurrent validity was examined using equivalence testing on EE (equivalence zone: 2,889.7-3,531.9 kcal); 2 trackers fell short of falling in the zone: PL (2,714.4-3,164.8 kcal) and FC (2,473.8-3,066.5 kcal). For SPT (equivalence zone: 420.6-514.0 minutes), several monitors fell in the zone: PL (448.3-485.6 minutes), MS (442.8-492.2 minutes), and FF (427.7-486.7 minutes). This study suggests that the PL and FC provide a reasonable estimate of EE under free-living conditions. The PL, FC, and MF were the most valid monitors used for measuring SPT.

  6. Noninvasive imaging of sialyltransferase activity in living cells by chemoselective recognition

    NASA Astrophysics Data System (ADS)

    Bao, Lei; Ding, Lin; Yang, Min; Ju, Huangxian

    2015-06-01

    To elucidate the biological and pathological functions of sialyltransferases (STs), intracellular ST activity evaluation is necessary. Focusing on the lack of noninvasive methods for obtaining the dynamic activity information, this work designs a sensing platform for in situ FRET imaging of intracellular ST activity and tracing of sialylation process. The system uses tetramethylrhodamine isothiocyanate labeled asialofetuin (TRITC-AF) as a ST substrate and fluorescein isothiocyanate labeled 3-aminophenylboronic acid (FITC-APBA) as the chemoselective recognition probe of sialylation product, both of which are encapsulated in a liposome vesicle for cellular delivery. The recognition of FITC-APBA to sialylated TRITC-AF leads to the FRET signal that is analyzed by FRET efficiency images. This strategy has been used to evaluate the correlation of ST activity with malignancy and cell surface sialylation, and the sialylation inhibition activity of inhibitors. This work provides a powerful noninvasive tool for glycan biosynthesis mechanism research, cancer diagnostics and drug development.

  7. Assisted Living

    MedlinePlus

    ... Recreational activities Security Transportation How to Choose a Facility A good match between a facility and a resident's needs depends as much on the philosophy and services of the assisted living facility as it does on the quality of care. ...

  8. A daily living activity remote monitoring system for solitary elderly people.

    PubMed

    Maki, Hiromichi; Ogawa, Hidekuni; Matsuoka, Shingo; Yonezawa, Yoshiharu; Caldwell, W Morton

    2011-01-01

    A daily living activity remote monitoring system has been developed for supporting solitary elderly people. The monitoring system consists of a tri-axis accelerometer, six low-power active filters, a low-power 8-bit microcontroller (MC), a 1GB SD memory card (SDMC) and a 2.4 GHz low transmitting power mobile phone (PHS). The tri-axis accelerometer attached to the subject's chest can simultaneously measure dynamic and static acceleration forces produced by heart sound, respiration, posture and behavior. The heart rate, respiration rate, activity, posture and behavior are detected from the dynamic and static acceleration forces. These data are stored in the SD. The MC sends the data to the server computer every hour. The server computer stores the data and makes a graphic chart from the data. When the caregiver calls from his/her mobile phone to the server computer, the server computer sends the graphical chart via the PHS. The caregiver's mobile phone displays the chart to the monitor graphically.

  9. Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems.

    PubMed

    Berthault, N; Maury, B; Agrario, C; Herbette, A; Sun, J-S; Peyrieras, N; Dutreix, M

    2011-10-01

    Introducing small DNA molecules (Dbait) impairs the repair of damaged chromosomes and provides a new method for enhancing the efficiency of radiotherapy in radio-resistant tumors. The radiosensitizing activity is dependent upon the efficient delivery of Dbait molecules into the tumor cells. Different strategies have been compared, to improve this key step. We developed a pipeline of assays to select the most efficient nanoparticles and administration protocols before preclinical assays: (i) molecular analyses of complexes formed with Dbait molecules, (ii) cellular tests for Dbait uptake and activity, (iii) live zebrafish embryo confocal microscopy monitoring for in vivo distribution and biological activity of the nanoparticles and (iv) tumor growth and survival measurement on mice with xenografted tumors. Two classes of nanoparticles were compared, polycationic polymers with linear or branched polyethylenimine (PEI) and covalently attached cholesterol (coDbait). The most efficient Dbait transfection was observed with linear PEI complexes, in vitro and in vivo. Doses of coDbait ten-fold higher than PEI/Dbait nanoparticles, and pretreatment with chloroquine, were required to obtain the same antitumoral effect on xenografted melanoma. However, with a 22-fold lower 'efficacy dose/toxicity dose' ratio as compared with Dbait/PEI, coDbait was selected for clinical trials.

  10. Garment-based detection of falls and activities of daily living using 3-axis MEMS accelerometer

    NASA Astrophysics Data System (ADS)

    Nyan, M. N.; Tay, Francis E. H.; Manimaran, M.; Seah, K. H. W.

    2006-04-01

    This paper studied the detection of falls and activities of daily living (ADL) with two objectives: (1) minimum number of sensors for a broad range of activities and (2) maximize the comfort of the wearer for long term use. We used a garment to provide long term comfort for the wearer, with a 3-axis MEMS accelerometer on the shoulder position, as a wearable platform. ADL were detected in time-frequency domain and summation of absolute peak values of 3-D acceleration signals was used as feature in fall detection. 6 male and female subjects performed approximately five-hour long experiment. Sensitivity of 94.98% and specificity of 98.83% for altogether 1495 activities were achieved. Our garment-based detection system fulfilled the objective of providing the comfort of the wearer in long term monitoring of falls and ADL with high sensitivity. In fall detection, our device can summon medical assistances via SMS (Short Message Service). This detection system can raise fall alarm (fall SMS) automatically to individuals to get a shortened interval of the arrival of assistance.

  11. Social participation and independence in activities of daily living: a cross sectional study

    PubMed Central

    Rubio, Encarnación; Lázaro, Angelina; Sánchez-Sánchez, Antonio

    2009-01-01

    Background It is today widely accepted that participation in social activities contributes towards successful ageing whilst, at the same time, maintaining independence in the activities of daily living (ADLs) is the sine qua non for achieving that end. This study looks at people aged 65 and over living in an urban area in Spain who retain the ability to attend Social Centres providing recreational facilities. The aim of this paper is to quantify independence and identify the risk factors involved in its deterioration. Methods The sample size was calculated using the equation for proportions in finite populations based on a random proportional sample type, absolute error (e) = 0.05, α = 0.05, β = 0.1, p = q = 0.5. Two-stage sampling was used. In the first place, the population was stratified by residence and a Social Centre was randomly chosen for each district. In the second stage, individuals were selected in a simple random sample without replacement in proportion to the number of members at each social centre. A multivariate logistical regression analysis takes functional ADL capacity as the dependent variable. The choice of predictive variables was made using a bivariate correlation matrix. Among the estimators obtained, Nagelkerke's R2 coefficient, and the Odds ratio (CI 95%) were considered. Sensitivity and 1-specificity were adopted to present the results in graphic form. Results Out of this sample, 63.7% were fully capable of carrying out ADLs, while the main factors contributing to deterioration, identified on the basis of a logistic regression model, are in order of importance, poor physical health, poor mental health, age (above 75 years) and gender (female). The model employed has a predictive value of 88% and 92% (depending on the age range considered) with regard to the independence in ADLs. Conclusion A review of the few Spanish works using similar methodology shows that the percentage of non-institutionalised persons who are independent enough to

  12. Energy Expenditures for Activities of Daily Living in Korean Young Adults: A Preliminary Study

    PubMed Central

    2016-01-01

    Objective To investigate the energy expenditure (EE) of Korean young adults based on activities refined to a deskbound lifestyle. Methods Sixty-four healthy office workers aged between 25 and 46 years participated in this study. EE was expressed as metabolic equivalent of task (MET). Participants were evaluated in terms of their EE during physical activities of sleeping (n=22), typing (n=37), folding laundry (n=34), dishwashing (n=32), studying (n=18), mopping (n=35), walking (n=33), stair climbing (n=23), and running (n=29). Volume of oxygen consumption was measured by indirect calorimetry K4b2 (COSMED). The results were compared to the established Compendium MET. Results The MET of activities were: sleeping, 1.24±0.43; typing, 1.35±0.25; folding laundry, 1.58±0.51; dishwashing, 2.20±0.51; studying, 2.11±0.90; mopping, 2.72±0.69; walking at 4 km/hr, 3.48±0.65; stair climbing of five stories, 6.18±1.08; and running at 8 km/hr, 7.57±0.57. The values of typing and mopping were similar to those in the Compendium, whereas those of sleeping, folding laundry, dishwashing, studying, walking, stair climbing and running were different. Conclusion To our knowledge, this estimation of EE in MET during activities of daily living is the first data of young adults in Korea. These data could be used as a reference to modify the guidelines of physical activities for the age group examined in this study. PMID:27606280

  13. Measuring Physical Activity in Free-Living Conditions—Comparison of Three Accelerometry-Based Methods

    PubMed Central

    Leinonen, Anna-Maiju; Ahola, Riikka; Kulmala, Janne; Hakonen, Harto; Vähä-Ypyä, Henri; Herzig, Karl-Heinz; Auvinen, Juha; Keinänen-Kiukaanniemi, Sirkka; Sievänen, Harri; Tammelin, Tuija H.; Korpelainen, Raija; Jämsä, Timo

    2017-01-01

    We examined the agreement in time spent on different physical activity (PA) levels using (1) mean amplitude deviation (MAD) of raw acceleration from the hip, (2) wrist-worn Polar Active, and (3) hip-worn Actigraph counts using Freedson's cut-points among adults under free-living conditions. PA was measured in 41 volunteers (mean age 47.6 years) for 14 days. Two MET-based threshold sets were used for MAD and Polar Active for sedentary time (ST) and time spent in light (LPA), moderate (MPA), and vigorous (VPA) PA. Actigraph counts were divided into PA classes, ≤100 counts/min for ST and Freedson's cut-points for LPA, MPA, and VPA. Analysis criteria were simultaneous use of devices for at least 4 days of >500 min/d. The between-method differences were analyzed using a repeated measures analysis of variance test. Bland-Altman plots and ROC graphs were also employed. Valid data were available from 27 participants. Polar Active produced the highest amount of VPA with both thresholds (≥5 and ≥6 MET; mean difference 17.9–30.9 min/d, P < 0.001). With the threshold 3–6 MET for MPA, Polar Active indicated 19.2 min/d more than MAD (95% CI 5.8–32.6) and 51.0 min/d more than Actigraph (95% CI 36.7–65.2). The results did not differ with 3.5–5 MET for MPA [F(1.44, 37.43) = 1.92, P = 0.170]. MAD and Actigraph were closest to each other for ST with the threshold < 1.5 MET (mean difference 22.2 min/d, 95% CI 7.1–37.3). With the threshold <2 MET, Polar Active and Actigraph provided similar results (mean difference 7.0 min/d, 95% CI −17.8–31.7). Moderate to high agreement (area under the ROC curve 0.806–0.963) was found between the methods for the fulfillment of the recommendation for daily moderate-to-vigorous PA of 60 min. In free-living conditions the agreement between MAD, Polar Active, and Actigraph for measuring time spent on different activity levels in adults was dependent on the activity thresholds used and PA intensity. ROC analyses showed moderate to

  14. Participation in Black Lives Matter and Deferred Action for Childhood Arrivals: Modern Activism among Black and Latino College Students

    ERIC Educational Resources Information Center

    Hope, Elan C.; Keels, Micere; Durkee, Myles I.

    2016-01-01

    Political activism is one way racially/ethnically marginalized youth can combat institutional discrimination and seek legislative change toward equality and justice. In the current study, we examine participation in #BlackLivesMatter (BLM) and advocacy for Deferred Action for Childhood Arrivals (DACA) as political activism popular among youth.…

  15. Finnish Research Activities relevant to IHY

    NASA Astrophysics Data System (ADS)

    Mursula, K.; Kauristie, K.; Vainio, R.

    Space physics is a traditional and strong field of research in Finland dating its early roots back to the mid-19th century i e several decennia before the First International Polar Year in 1882 Measurements of rapid variations of the geomagnetic field started in Helsinki already in 1844 and form now some of the longest and most uniform series of observations measuring the global state of the heliosphere Even further in the north at the Sodankyla Geophysical Observatory SGO continuous measurements span more than 90 years Today space physics activities are conducted mainly in the Universities of Helsinki HU Oulu OU and Turku TU and in the Finnish Meteorological Institute FMI SGO which maintains a versatile set of ground-based instrumentation belongs to OU Although several fields of common interest exist each of these parties also have their own research areas and specific expertise TU has a strong experimental and theoretical program in solar energetic particles HU has a wide program in planetary research as well as in auroral magnetosphere-ionosphere coupling and theoretical space plasma physics OU and SGO have a strong involvement in ionospheric physics as well as in solar-terrestrial and heliospheric physics HU has long been active in space weather projects while OU is a key player in space climate i e in the research of long-term changes in the Sun heliosphere and the near-Earth space As one part of this cosmic rays have been continuously measured in Oulu since 42 years In addition to the versatile ground-based instrumentation

  16. Factors associated with the recovery of activities of daily living after hospitalization for acute medical illness: a prospective cohort study

    PubMed Central

    Goto, Ryohei; Watanabe, Hiroki; Tsutsumi, Madoka; Kanamori, Takeshige; Maeno, Tetsuhiro; Yanagi, Hisako

    2016-01-01

    [Purpose] This study investigated the factors associated with the recovery rate of activities of daily living of elderly patients hospitalized for acute medical illness. [Subjects and Methods] A total of 238 elderly patients were enrolled in this study. The main outcome measure was the functional independence measure score which was used as an assessment of activities of daily living. The participants were divided into 2 groups based on their activities of daily living before onset: the independent group and the partially dependent group. The participants of each group were further divided into 2 subgroups based on recovery rates of activities of daily living: the high-recovery group (80%) and the low-recovery group (<80%). The factors associated with the recovery rate were examined using multivariate logistic regression analysis. [Results] The factors associated with the recovery rate were: days of inactivity and cognitive status at the start of rehabilitation for the independent group, and days of inactivity and nutritional status at the start of rehabilitation for the partially dependent group. [Conclusion] The results of this study suggest that the important factors for return to normal activities of daily living are: days of inactivity and cognitive status for the independent group; and days of inactivity and management of nutrition for the partially dependent group. PMID:27821931

  17. [A statistical analysis of factors influencing standing balance, activity of daily living and ambulation in hemiplegic patients].

    PubMed

    Nogaki, H

    1992-04-01

    This study was undertaken to investigate several factors influencing standing balance, activity of daily living and ambulation in hemiplegic patients after cerebro-vascular diseases. A statistical analysis of 121 hemiplegic patients with unilateral supratentorial lesions showed that age, severity of muscle weakness of involved or uninvolved extremities, unilateral spatial neglect and the sense of toe position had influence on standing balance, activity of daily living or ambulation. The patients were divided into five groups based on the degree of unilateral spatial neglect, evaluated by their copies of two daisies who omitted more than three quarters, three quarters, half, one quarter and none of the figures were defined as the USN-4, USN-3, USN-2, USN-1 and no involvement groups, respectively. Those who belonged to the USN-2 group had significantly lower scores for activity of daily living than those who belonged to the no involvement group. In the USN-2 group, 7 of the 8 patients could not keep standing for 50 seconds, while in the no involvement group, this was the case in only 1 of the 15 patients. Activity of daily living scores or sway area during standing showed no statistically significant differences between the USN-1 and no involvement groups. These results suggested that severe or moderate unilateral spatial neglect is one of the most important factors influencing standing balance and activity of daily living.

  18. Relations of morale and physical function to advanced activities of daily living in health promotion class participants

    PubMed Central

    Yajima, Masahide; Asakawa, Yasuyoshi; Yamaguchi, Haruyasu

    2016-01-01

    [Purpose] The aim of this study was to clarify the relations of morale and physical function to the presence/absence of advanced activities of daily living. [Subjects] The subjects were 86 elderly community residents participating in health promotion classes. [Methods] A questionnaire survey on age, gender, presence/absence of advanced activities of daily living, and Philadelphia Geriatric Center Morale Scale score was conducted, in addition to assessment of fitness, consisting of measurement of height, body weight, grip and knee extensor muscle strength, functional reach, one-leg standing time, and Timed Up and Go test. Furthermore, multiple logistic regression analysis was performed with the presence/absence of advanced activities of daily living as a dependent variable. [Results] Grip strength and Timed Up and Go time were identified as variables influencing the presence/absence of advanced activities of daily living. [Conclusion] Physical function represented by grip strength and Timed Up and Go time was higher among subjects performing advanced activities of daily living. PMID:27065541

  19. Adding delayed recall to the ADAS-cog improves measurement precision in mild Alzheimer's disease: Implications for predicting instrumental activities of daily living.

    PubMed

    Lowe, Deborah A; Balsis, Steve; Benge, Jared F; Doody, Rachelle S

    2015-12-01

    As research increasingly focuses on preclinical stages of Alzheimer's disease (AD), instruments must be retooled to identify early cognitive markers of AD. A supplemental delayed recall subtest for the Alzheimer's Disease Assessment Scale-cognitive (ADAS-cog; Mohs, Rosen, & Davis, 1983; Rosen, Mohs, & Davis, 1984) is commonly implemented, but it is not known precisely where along the spectrum of cognitive dysfunction this subtest yields incremental information beyond what is gained from the standard ADAS-cog, or whether it can improve prediction of functional outcomes. An item response theory approach can analyze this in a psychometrically rigorous way. Seven hundred eighty-eight patients with AD or amnestic complaints or impairment completed a battery including the ADAS-cog and 2 activities of daily living measures. The delayed recall subtest slightly improved the ADAS-cog's measurement precision in the mild range of cognitive dysfunction and increased prediction of instrumental activities of daily living for individuals with subjective memory impairment.

  20. Estimating Physical Activity and Sedentary Behavior in a Free-Living Context: A Pragmatic Comparison of Consumer-Based Activity Trackers and ActiGraph Accelerometry

    PubMed Central

    Ng, Norman; Burton, Nicola W; Pavey, Toby G; Gilson, Nicholas D; Brown, Wendy J

    2016-01-01

    Background Activity trackers are increasingly popular with both consumers and researchers for monitoring activity and for promoting positive behavior change. However, there is a lack of research investigating the performance of these devices in free-living contexts, for which findings are likely to vary from studies conducted in well-controlled laboratory settings. Objective The aim was to compare Fitbit One and Jawbone UP estimates of steps, moderate-to-vigorous physical activity (MVPA), and sedentary behavior with data from the ActiGraph GT3X+ accelerometer in a free-living context. Methods Thirty-two participants were recruited using convenience sampling; 29 provided valid data for this study (female: 90%, 26/29; age: mean 39.6, SD 11.0 years). On two occasions for 7 days each, participants wore an ActiGraph GT3X+ accelerometer on their right hip and either a hip-worn Fitbit One (n=14) or wrist-worn Jawbone UP (n=15) activity tracker. Daily estimates of steps and very active minutes were derived from the Fitbit One (n=135 days) and steps, active time, and longest idle time from the Jawbone UP (n=154 days). Daily estimates of steps, MVPA, and longest sedentary bout were derived from the corresponding days of ActiGraph data. Correlation coefficients and Bland-Altman plots with examination of systematic bias were used to assess convergent validity and agreement between the devices and the ActiGraph. Cohen’s kappa was used to assess the agreement between each device and the ActiGraph for classification of active versus inactive (≥10,000 steps per day and ≥30 min/day of MVPA) comparable with public health guidelines. Results Correlations with ActiGraph estimates of steps and MVPA ranged between .72 and .90 for Fitbit One and .56 and .75 for Jawbone UP. Compared with ActiGraph estimates, both devices overestimated daily steps by 8% (Fitbit One) and 14% (Jawbone UP). However, mean differences were larger for daily MVPA (Fitbit One: underestimated by 46%; Jawbone

  1. Microscopy in Space Research: Learning More About Gravitational Effects on Living Systems

    NASA Technical Reports Server (NTRS)

    Ross, Muriel D.

    1994-01-01

    Investigators are using light, scanning and transmission electron microscopic (TEM) methods to investigate the effects of microgravity on the development, maintenance and aging of biological systems. The capabilities of the spacelab for life sciences research in space will be described. Among the many results to be discussed are the effects of microgravity on amphibian fertilization and early development, and on the rodent musculoskeletal and neural systems. Xenopus laevis eggs fertilized in space developed normally during and after an eight day spaceflight. Ultrastructural studies of rodent tissue demonstrated that spaceflight-induced atrophy of antigravity skeletal muscles renders muscle fibers susceptible to structural failure upon return to weight bearing postflight. Principle TEM changes in neuromuscular junctions are the decrease or absence of synaptic vesicles and degeneration of axon terminals. In bone, architectural rather than compositional changes may be the primary perturbation. Thus, many techniques used on Earth (such as density determinations) would not detect significant changes in bone strength. An increment in synaptic number and changes in synapse distribution occur in peripheral gravity sensors. There is a decrease in muscarinic cholinergic receptor density in the striatum. Striatal receptor changes suggest spaceflight-related alterations in motor activity. Opportunities for future life sciences research in space will be discussed.

  2. Healthy Active Living: A Residence Community-Based Intervention to Increase Physical Activity and Healthy Eating during the Transition to First-Year University

    ERIC Educational Resources Information Center

    Brown, Denver M. Y.; Bray, Steve R.; Beatty, Kevin R.; Kwan, Matthew Y. W.

    2014-01-01

    Objective: To examine the effects of a Healthy Active Living (HAL) community intervention on moderate-to-vigorous physical activity (MVPA), fruit and vegetable consumption (FVC), and psychosocial mediators of physical activity among students transitioning into university. Methods: Sixty undergraduate students were assigned to reside in either the…

  3. [Frontiers in Live Bone Imaging Researches. In vivo imaging of bone marrow microenvironment].

    PubMed

    Mizuno, Hiroki; Ishii, Masaru

    2015-06-01

    The function of hematopoietic stem cells and leukemia stem cells depends on their interaction with complex microenvironment within the bone marrow. Conventional methods could not observe the dynamic cell movement in living bone marrow. Recently rapid development of live imaging techniques enables us to understand the cellular interaction. Intravital two-photon imaging is the ideal method to understand the nature of bone marrow because of visualizing the cellular dynamics in vivo and observing the bone marrow long time. Here we show the latest reports about bone marrow microenvironment by intravital imaging, and also discuss its further application.

  4. Plug&Play Brain-Computer Interfaces for effective Active and Assisted Living control.

    PubMed

    Mora, Niccolò; De Munari, Ilaria; Ciampolini, Paolo; Del R Millán, José

    2016-11-17

    Brain-Computer Interfaces (BCI) rely on the interpretation of brain activity to provide people with disabilities with an alternative/augmentative interaction path. In light of this, BCI could be considered as enabling technology in many fields, including Active and Assisted Living (AAL) systems control. Interaction barriers could be removed indeed, enabling user with severe motor impairments to gain control over a wide range of AAL features. In this paper, a cost-effective BCI solution, targeted (but not limited) to AAL system control is presented. A custom hardware module is briefly reviewed, while signal processing techniques are covered in more depth. Steady-state visual evoked potentials (SSVEP) are exploited in this work as operating BCI protocol. In contrast with most common SSVEP-BCI approaches, we propose the definition of a prediction confidence indicator, which is shown to improve overall classification accuracy. The confidence indicator is derived without any subject-specific approach and is stable across users: it can thus be defined once and then shared between different persons. This allows some kind of Plug&Play interaction. Furthermore, by modelling rest/idle periods with the confidence indicator, it is possible to detect active control periods and separate them from "background activity": this is capital for real-time, self-paced operation. Finally, the indicator also allows to dynamically choose the most appropriate observation window length, improving system's responsiveness and user's comfort. Good results are achieved under such operating conditions, achieving, for instance, a false positive rate of 0.16 min(-1), which outperform current literature findings.

  5. Sustaining active-living communities over the decades: lessons from a 1930s Greenbelt town.

    PubMed

    Ahrentzen, Sherry

    2008-06-01

    Greendale, Wisconsin, was intentionally created with many of the design and planning principles that active-living advocates promote today. This case study examines the processes behind sustaining these particular planning and design principles over time in light of economic and regional challenges that have faced not just Greendale but most town centers over the last fifty years. Despite these challenges, the walkable nature of Greendale's center remains strong today, in terms of both activity and community identity. While many circumstances are specific to this particular town, useful lessons can be drawn for those new urbanist (NU) communities being developed in greenfields and suburbs today, many of which are strikingly similar to Greendale - relatively small, low density, and located within metropolitan areas. Greendale's success resulted from (1) attending to the retail/commercial product mix; (2) attracting nonresidents to use the community's retail and public space; and (3) capitalizing on community investment not simply from residents' organizing efforts but, more important in this case, from corporate community involvement by a Greendale business firm whose interests and values coincided with those of the community.

  6. Range of Motion Requirements for Upper-Limb Activities of Daily Living

    PubMed Central

    Walters, Lisa Smurr; Cowley, Jeffrey; Wilken, Jason M.; Resnik, Linda

    2016-01-01

    OBJECTIVE. We quantified the range of motion (ROM) required for eight upper-extremity activities of daily living (ADLs) in healthy participants. METHOD. Fifteen right-handed participants completed several bimanual and unilateral basic ADLs while joint kinematics were monitored using a motion capture system. Peak motions of the pelvis, trunk, shoulder, elbow, and wrist were quantified for each task. RESULTS. To complete all activities tested, participants needed a minimum ROM of −65°/0°/105° for humeral plane angle (horizontal abduction–adduction), 0°–108° for humeral elevation, −55°/0°/79° for humeral rotation, 0°–121° for elbow flexion, −53°/0°/13° for forearm rotation, −40°/0°/38° for wrist flexion–extension, and −28°/0°/38° for wrist ulnar–radial deviation. Peak trunk ROM was 23° lean, 32° axial rotation, and 59° flexion–extension. CONCLUSION. Full upper-limb kinematics were calculated for several ADLs. This methodology can be used in future studies as a basis for developing normative databases of upper-extremity motions and evaluating pathology in populations. PMID:26709433

  7. Palladium-triggered deprotection chemistry for protein activation in living cells

    NASA Astrophysics Data System (ADS)

    Li, Jie; Yu, Juntao; Zhao, Jingyi; Wang, Jie; Zheng, Siqi; Lin, Shixian; Chen, Long; Yang, Maiyun; Jia, Shang; Zhang, Xiaoyu; Chen, Peng R.

    2014-04-01

    Employing small molecules or chemical reagents to modulate the function of an intracellular protein, particularly in a gain-of-function fashion, remains a challenge. In contrast to inhibitor-based loss-of-function approaches, methods based on a gain of function enable specific signalling pathways to be activated inside a cell. Here we report a chemical rescue strategy that uses a palladium-mediated deprotection reaction to activate a protein within living cells. We identify biocompatible and efficient palladium catalysts that cleave the propargyl carbamate group of a protected lysine analogue to generate a free lysine. The lysine analogue can be genetically and site-specifically incorporated into a protein, which enables control over the reaction site. This deprotection strategy is shown to work with a range of different cell lines and proteins. We further applied this biocompatible protection group/catalyst pair for caging and subsequent release of a crucial lysine residue in a bacterial Type III effector protein within host cells, which reveals details of its virulence mechanism.

  8. Assessing Upper Extremity Motor Function in Practice of Virtual Activities of Daily Living

    PubMed Central

    Adams, Richard J.; Lichter, Matthew D.; Krepkovich, Eileen T.; Ellington, Allison; White, Marga; Diamond, Paul T.

    2015-01-01

    A study was conducted to investigate the criterion validity of measures of upper extremity (UE) motor function derived during practice of virtual activities of daily living (ADLs). Fourteen hemiparetic stroke patients employed a Virtual Occupational Therapy Assistant (VOTA), consisting of a high-fidelity virtual world and a Kinect™ sensor, in four sessions of approximately one hour in duration. An Unscented Kalman Filter-based human motion tracking algorithm estimated UE joint kinematics in real-time during performance of virtual ADL activities, enabling both animation of the user’s avatar and automated generation of metrics related to speed and smoothness of motion. These metrics, aggregated over discrete sub-task elements during performance of virtual ADLs, were compared to scores from an established assessment of UE motor performance, the Wolf Motor Function Test (WMFT). Spearman’s rank correlation analysis indicates a moderate correlation between VOTA-derived metrics and the time-based WMFT assessments, supporting the criterion validity of VOTA measures as a means of tracking patient progress during an UE rehabilitation program that includes practice of virtual ADLs. PMID:25265612

  9. Can activities of daily living contribute to EMG normalization for gait analysis?

    PubMed Central

    Ghazwan, Aseel; Forrest, Sarah M.; Holt, Cathy A.; Whatling, Gemma M.

    2017-01-01

    This study aims to examine alternative methods of normalization that effectively reflect muscle activity as compared to Maximal Voluntary Contraction (MVC). EMG data recorded from knee flexion-extension muscles in 10 control subjects during the stance phase of the gait cycle were examined by adopting different approaches of normalization: MVC, Mean and Peak Dynamic during gait cycles, (MDM and PDM, respectively), Peak Dynamic during activities of daily living (ADLs), (*PDM), and a combination of ADLs and MVC(**PDM). Intra- and inter-individual variability were calculated to determine reliability and similarity to MCV. **PDM showed excellent reliability across subjects in comparison to MVC, where variance ratio ranged from 0.43–0.99 for **PDM and 0.79–1.08 for MVC. Coefficient of variability showed a similar trend to Variance Ratio, ranging from 0.60–1.25 for **PDM and 1.97–3.92 for MVC. Both MVC and **PDM, and to some extent *PDM, demonstrated good-to-excellent relative amplitude’s matching; i.e. root mean square difference and absolute difference were both around 0.08 for Vastus medialis to about 4 for Medial gastrocnemius. It was concluded that **PDM and *PDM were reliable, **PDM mirrored MVC and thus could be used as an alternative to MVC for subjects who are unable to provide the required effort for MVC testing. Where MVC testing is not possible, *PDM is the next preferred option. PMID:28369104

  10. Can activities of daily living contribute to EMG normalization for gait analysis?

    PubMed

    Ghazwan, Aseel; Forrest, Sarah M; Holt, Cathy A; Whatling, Gemma M

    2017-01-01

    This study aims to examine alternative methods of normalization that effectively reflect muscle activity as compared to Maximal Voluntary Contraction (MVC). EMG data recorded from knee flexion-extension muscles in 10 control subjects during the stance phase of the gait cycle were examined by adopting different approaches of normalization: MVC, Mean and Peak Dynamic during gait cycles, (MDM and PDM, respectively), Peak Dynamic during activities of daily living (ADLs), (*PDM), and a combination of ADLs and MVC(**PDM). Intra- and inter-individual variability were calculated to determine reliability and similarity to MCV. **PDM showed excellent reliability across subjects in comparison to MVC, where variance ratio ranged from 0.43-0.99 for **PDM and 0.79-1.08 for MVC. Coefficient of variability showed a similar trend to Variance Ratio, ranging from 0.60-1.25 for **PDM and 1.97-3.92 for MVC. Both MVC and **PDM, and to some extent *PDM, demonstrated good-to-excellent relative amplitude's matching; i.e. root mean square difference and absolute difference were both around 0.08 for Vastus medialis to about 4 for Medial gastrocnemius. It was concluded that **PDM and *PDM were reliable, **PDM mirrored MVC and thus could be used as an alternative to MVC for subjects who are unable to provide the required effort for MVC testing. Where MVC testing is not possible, *PDM is the next preferred option.

  11. Measuring CREB activation using bioluminescent probes that detect KID-KIX interaction in living cells.

    PubMed

    Ishimoto, Tetsuya; Mano, Hiroki; Ozawa, Takeaki; Mori, Hisashi

    2012-05-16

    The cyclic adenosine monophosphate response element-binding protein (CREB) is a transcription factor that contributes to memory formation. The transcriptional activity of CREB is induced by its phosphorylation at Ser-133 and subsequent interaction with the CREB-binding protein (CBP)/p300. We designed and optimized firefly split luciferase probe proteins that detect the interaction of the kinase-inducible domain (KID) of CREB and the KIX domain of CBP/p300. The increase in the light intensity of the probe proteins results from the phosphorylation of the responsible serine corresponding to Ser-133 of CREB. Because these proteins have a high signal-to-noise ratio and are nontoxic, it has become possible for the first time to carry out long-term measurement of KID-KIX interaction in living cells. Furthermore, we examined the usefulness of the probe proteins for future high-throughput cell-based drug screening and found several herbal extracts that activated CREB.

  12. Effects of therapeutic Tai chi on functional fitness and activities of daily living in patients with Parkinson disease.

    PubMed

    Choi, Hye-Jung

    2016-10-01

    The purpose of the study is to investigate the effects of therapeutic Tai chi (TTC) on the functional fitness status and activities of daily living (ADL) of patients with Parkinson disease (PD). The participants were clinically stable PDs in Hoehn and Yahr stage 1-2. These patients were randomly assigned to either the TTC group (n=11) or the control (CON) group (n=9). The TTC exercised at the clinic 2 times a week and performed home-based activity 1 time per week for 12 weeks. All the PDs were evaluated for functional fitness test and ADL screen before and after the 12-week trial. There was a significant Time × group interaction effect on the arm curl (P<0.01), functional reach (P<0.05), and stand on foot with eyes opened (P<0.05) of the functional fitness as compared to the CON. The results of the functional reach test in the CON worsened significantly during the 12-week intervention in comparison with those of the TTC (P<0.01). Also ADL showed significant changed in TCC (P<0.05). Tai chi training showed good effects on the functional fitness in PDs. This study suggests that further research into the based such as Tai chi intervention must be developed PD's quality of life in the future.

  13. Effects of therapeutic Tai chi on functional fitness and activities of daily living in patients with Parkinson disease

    PubMed Central

    Choi, Hye-Jung

    2016-01-01

    The purpose of the study is to investigate the effects of therapeutic Tai chi (TTC) on the functional fitness status and activities of daily living (ADL) of patients with Parkinson disease (PD). The participants were clinically stable PDs in Hoehn and Yahr stage 1–2. These patients were randomly assigned to either the TTC group (n=11) or the control (CON) group (n=9). The TTC exercised at the clinic 2 times a week and performed home-based activity 1 time per week for 12 weeks. All the PDs were evaluated for functional fitness test and ADL screen before and after the 12-week trial. There was a significant Time × group interaction effect on the arm curl (P<0.01), functional reach (P<0.05), and stand on foot with eyes opened (P<0.05) of the functional fitness as compared to the CON. The results of the functional reach test in the CON worsened significantly during the 12-week intervention in comparison with those of the TTC (P<0.01). Also ADL showed significant changed in TCC (P<0.05). Tai chi training showed good effects on the functional fitness in PDs. This study suggests that further research into the based such as Tai chi intervention must be developed PD’s quality of life in the future. PMID:27807532

  14. Positive Activities: Qualitative Research with Parents. Solutions Research. Research Report. DCSF-RR142

    ERIC Educational Resources Information Center

    Department for Children, Schools and Families, 2009

    2009-01-01

    This research was commissioned by COI and DCSF to understand in depth, the barriers, motivators and messages for parents to encourage participation in positive activities for young people. Within this the research was designed to understand the level of influence of parents in whether a young person participates/what a young person might…

  15. Electromechanically active polymer transducers: research in Europe

    NASA Astrophysics Data System (ADS)

    Carpi, Federico; Graz, Ingrid; Jager, Edwin; Ladegaard Skov, Anne; Vidal, Frédéric

    2013-10-01

    Smart materials and structures based on electromechanically active polymers (EAPs) represent a fast growing and stimulating field of research and development. EAPs are materials capable of changing dimensions and/or shape in response to suitable electrical stimuli. They are commonly classified in two major families: ionic EAPs (activated by an electrically induced transport of ions and/or solvent) and electronic EAPs (activated by electrostatic forces). These polymers show interesting properties, such as sizable active strains and/or stresses in response to electrical driving, high mechanical flexibility, low density, structural simplicity, ease of processing and scalability, no acoustic noise and, in most cases, low costs. Since many of these characteristics can also describe natural muscle tissues from an engineering standpoint, it is not surprising that EAP transducers are sometimes also referred to as 'muscle-like smart materials' or 'artificial muscles'. They are used not only to generate motion, but also to sense or harvest energy from it. In particular, EAP electromechanical transducers are studied for applications that can benefit from their 'biomimetic' characteristics, with possible usages from the micro- to the macro-scale, spanning several disciplines, such as mechatronics, robotics, automation, biotechnology and biomedical engineering, haptics, fluidics, optics and acoustics. Currently, the EAP field is just undergoing its initial transition from academic research into commercialization, with companies starting to invest in this technology and the first products appearing on the market. This focus issue is intentionally aimed at gathering contributions from the most influential European groups working in the EAP field. In fact, today Europe hosts the broadest EAP community worldwide. The rapid expansion of the EAP field in Europe, where it historically has strong roots, has stimulated the creation of the 'European Scientific Network for Artificial

  16. Effects of community-based rehabilitation program on activities of daily living and cognition in elderly chronic stroke survivors

    PubMed Central

    Park, Young-Ju; Lee, Chun-Yeop

    2016-01-01

    [Purpose] The aim of this study was to examine the effects of community-based rehabilitation program in chronic stroke patients. [Subjects and Methods] Eleven subjects received community-based rehabilitation program ten times for ten months. The main outcome measures were the Modified Barthel Index score for activities of daily living and the Korean Mini-Mental State Examination score for cognition. [Results] The results of the study demonstrated that the community-based rehabilitation program improved activities of daily living performance and cognition significantly. [Conclusion] Based on the study results, the community-based rehabilitation program is an effective method for improving activities of daily living performance and cognitive function in elderly patients with chronic stroke. PMID:27942164

  17. Patterns of Living in California's Migrant Labor Families. Research Monograph No. 12.

    ERIC Educational Resources Information Center

    Hawkes, Glenn R.; And Others

    This report presents a study of the living patterns of California's migrant labor families, one part of a national study on the identification of life patterns among relatively disadvantaged families. Data were collected from 169 interviews with homemakers randomly selected from 12 state-owned migrant camps in California. The interviews consisted…

  18. Children with Osteogenesis Imperfecta and Their Daily Living. Handicap Research Group Report No. 4.

    ERIC Educational Resources Information Center

    Brodin, Jane

    The study examined aspects of daily living of Swedish children with osteogenesis imperfecta, a mineral deficiency in the skeleton which results in stunted growth and frequent fractures. A questionnaire was administered to 24 families with children under the age of 18 and 3 families were interviewed. The study found the families in great need of…

  19. Assistive devices in activities of daily living used by persons with age-related macular degeneration: a population study of 85-year-olds living at home.

    PubMed

    Dahlin Ivanoff, S; Sonn, U

    2005-03-01

    The purpose of this study was to investigate the overall use of assistive devices among persons with age-related macular degeneration (ARMD) and how it is related to dependence in daily activities. This was a retrospective, descriptive, cross-sectional population study of 85-year-olds. The most common category of assistive devices was bathing devices followed by mobility devices. The overall use of assistive devices was 82%, and around 80% of the device users were independent in activities of daily living. They were multiple device users (57%) and used more mobility devices and personal assistance in mobility. In conclusion, the ARMD group comprises very frequent users of assistive devices and uses assistive devices to remain independent. This implies that health services should provide assistive devices at an early stage in the disablement process to avoid the development of dependence and should consider the likelihood of multiple health problems when assessing the needs of assistive devices among persons with ARMD.

  20. Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform.

    PubMed

    Kapishon, Vitaliy; Allison, Stephanie; Whitney, Ralph A; Cunningham, Michael F; Szewczuk, Myron R; Neufeld, Ronald J

    2016-03-01

    Targeted drug delivery using polymeric nanostructures has been at the forefront of cancer research, engineered for safer, more efficient and effective use of chemotherapy. Here, we designed a new polymeric micelle delivery system for active tumor targeting followed by micelle-drug internalization via receptor-induced endocytosis. We recently reported that oseltamivir phosphate targets and inhibits Neu1 sialidase activity associated with receptor tyrosine kinases such as epidermal growth factor receptors (EGFRs) which are overexpressed in cancer cells. By decorating micelles with oseltamivir, we investigated whether they actively targeted human pancreatic PANC1 cancer cells. Amphiphilic block copolymers with oseltamivir conjugated at the hydrophilic end, oseltamivir-pPEGMEMA-b-pMMA (oseltamivir-poly(polyethylene glycol methyl ether methacrylate)-block-poly(methyl methacrylate), were synthesized using reversible addition-fragmentation chain transfer (RAFT) living radical polymerization. Oseltamivir-conjugated micelles have self-assembling properties to give worm-like micellar structures with molecular weight of 80 000 g mol(-1). Oseltamivir-conjugated water soluble pPEGMEMA, dose dependently, both inhibited sialidase activity associated with Neu1, and reduced viability of PANC1 cells. In addition, oseltamivir-conjugated micelles, labelled with a hydrophobic fluorescent dye within the micelle core, were subsequently internalized by PANC1 cells. Blocking cell surface Neu1 with anti-Neu1 antibody, reduced internalization of oseltamivir-conjugated micelles, demonstrating that Neu1 binding linked to sialidase inhibition were prerequisite steps for subsequent internalization of the micelles. The mechanism of internalization is likely that of receptor-induced endocytosis demonstrating potential as a new nanocarrier system for not only targeting a tumor cell, but also for directly reducing viability through Neu1 inhibition, followed by intracellular delivery of hydrophobic

  1. Public open space, physical activity, urban design and public health: Concepts, methods and research agenda.

    PubMed

    Koohsari, Mohammad Javad; Mavoa, Suzanne; Villanueva, Karen; Sugiyama, Takemi; Badland, Hannah; Kaczynski, Andrew T; Owen, Neville; Giles-Corti, Billie

    2015-05-01

    Public open spaces such as parks and green spaces are key built environment elements within neighbourhoods for encouraging a variety of physical activity behaviours. Over the past decade, there has been a burgeoning number of active living research studies examining the influence of public open space on physical activity. However, the evidence shows mixed associations between different aspects of public open space (e.g., proximity, size, quality) and physical activity. These inconsistencies hinder the development of specific evidence-based guidelines for urban designers and policy-makers for (re)designing public open space to encourage physical activity. This paper aims to move this research agenda forward, by identifying key conceptual and methodological issues that may contribute to inconsistencies in research examining relations between public open space and physical activity.

  2. Motor Skills and Free-Living Physical Activity Showed No Association Among Preschoolers in 2012 U.S. National Youth Fitness Survey.

    PubMed

    Loprinzi, Paul D; Frith, Emily

    2017-04-01

    Albeit limited, some emerging work, using convenience-based samples, has demonstrated that greater motor skill development is associated with higher physical activity among preschool-aged children. The purpose of this study was to evaluate this topic using data from the 2012 National Youth Fitness Survey that included 329 preschool-aged children (3-5 years). Parents proxy-reported their child's physical activity, with motor skill level assessed from the Test of Gross Motor Development-Second Edition (TGMD2). Motor skill levels (Gross Motor Quotient, locomotor or object control) were not associated with preschool free-living physical activity in any analytic model. Thus, in this large sample of preschoolers, contrary to research with older children, motor skill level was not associated with physical activity. Findings are discussed in terms of study limitations of (a) a reliance on parent report of children's physical activity levels and (b) the possibility that physical activity data within the national survey were too limited in range to show possible associations to motor skill development with higher levels of free-living physical activity in preschoolers.

  3. Does methodology matter in eyewitness identification research? The effect of live versus video exposure on eyewitness identification accuracy.

    PubMed

    Pozzulo, Joanna D; Crescini, Charmagne; Panton, Tasha

    2008-01-01

    The present study examined the effect of mode of target exposure (live versus video) on eyewitness identification accuracy. Adult participants (N=104) were exposed to a staged crime that they witnessed either live or on videotape. Participants were then asked to rate their stress and arousal levels prior to being presented with either a target-present or -absent simultaneous lineup. Across target-present and -absent lineups, mode of target exposure did not have a significant effect on identification accuracy. However, mode of target exposure was found to have a significant effect on stress and arousal levels. Participants who witnessed the crime live had higher levels of stress and arousal than those who were exposed to the videotaped crime. A higher level of arousal was significantly related to poorer identification accuracy for those in the video condition. For participants in the live condition however, stress and arousal had no effect on eyewitness identification accuracy. Implications of these findings in regards to the generalizability of laboratory-based research on eyewitness testimony to real-life crime are discussed.

  4. Skill Activities for Independent Living (SAIL). A Curriculum for Developmentally Disabled Adolescents and Adults.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. Center for Mental Retardation.

    This curriculum for developmentally disabled adolescents and adults contains assessment conditions and performance criteria for evaluating client acquisition of a total of 646 independent living skills in five areas. While the content of the curriculum is in an area known as independent living, it is also prevocational in as much as it covers a…

  5. Interpretative phenomenological analysis as a useful methodology for research on the lived experience of pain

    PubMed Central

    Osborn, Mike

    2015-01-01

    Interpretative phenomenological analysis (IPA) is a qualitative approach which aims to provide detailed examinations of personal lived experience. It produces an account of lived experience in its own terms rather than one prescribed by pre-existing theoretical preconceptions and it recognises that this is an interpretative endeavour as humans are sense-making organisms. It is explicitly idiographic in its commitment to examining the detailed experience of each case in turn, prior to the move to more general claims. IPA is a particularly useful methodology for examining topics which are complex, ambiguous and emotionally laden. Pain is a prime exemplar of such a phenomenon: elusive, involving complex psycho-somatic interactions and difficult to articulate. In addition to the 1998 article, published in this Special Issue, two further papers are suggested that the interested reader might wish to look out for. PMID:26516556

  6. Biomechanical Characteristics of Hand Coordination in Grasping Activities of Daily Living

    PubMed Central

    Liu, Ming-Jin; Xiong, Cai-Hua; Xiong, Le; Huang, Xiao-Lin

    2016-01-01

    Hand coordination can allow humans to have dexterous control with many degrees of freedom to perform various tasks in daily living. An important contributing factor to this important ability is the complex biomechanical architecture of the human hand. However, drawing a clear functional link between biomechanical architecture and hand coordination is challenging. It is not understood which biomechanical characteristics are responsible for hand coordination and what specific effect each biomechanical characteristic has. To explore this link, we first inspected the characteristics of hand coordination during daily tasks through a statistical analysis of the kinematic data, which were collected from thirty right-handed subjects during a multitude of grasping tasks. Then, the functional link between biomechanical architecture and hand coordination was drawn by establishing the clear corresponding causality between the tendinous connective characteristics of the human hand and the coordinated characteristics during daily grasping activities. The explicit functional link indicates that the biomechanical characteristic of tendinous connective architecture between muscles and articulations is the proper design by the Creator to perform a multitude of daily tasks in a comfortable way. The clear link between the structure and the function of the human hand also suggests that the design of a multifunctional robotic hand should be able to better imitate such basic architecture. PMID:26730579

  7. Measuring acute changes in adrenergic nerve activity of the heart in the living animal

    SciTech Connect

    Sisson, J.C.; Bolgos, G.; Johnson, J. )

    1991-04-01

    Changes in the function of the adrenergic neurons of the heart may be important indicators of the adaptations of an animal to physiologic stress and disease. Rates of loss of norepinephrine (NE) from the heart were considered to be proportional to NE secretion and to adrenergic function. In rat hearts, yohimbine induced almost identical increases in rates of loss of {sup 3}H-NE and of {sup 125}I-metaiodobenzylguanidine (MIBG), a functional analog of NE. Clonidine induced decreases in rates of loss of {sup 3}H-NE that were also mimicked by those of {sup 125}I-MIBG. In the dog heart, pharmacologically-induced increases and decreases in rates of loss of {sup 123}I-MIBG could be measured externally; these values were similar to those obtained for {sup 125}I-MIBG in the rat heart. Thus acute changes in the adrenergic neuron activity can be measured in the living heart. The method is applicable to man in determining the capacity of the adrenergic system to respond to provocative challenges.

  8. Promoting Physical Activity among Children: The “Great Live and Move Challenge”

    PubMed

    Mourgues, Marion; Gourlan, Mathieu; Coste, Olivier; Fregeac, Bruno; Mora, Lucile; Cousson-Gélie, Florence

    2016-06-08

    Objective: The “Great Live and Move Challenge” (GLMC) is an intervention designed to promote physical activity (PA) in schools and the community among 6- to 11-year-old schoolchildren and their families.Method: This project, implemented in the Montpellier and Pays Coeur d’Hérault regions since 2013, encourages children to quantify their daily PA level by illustrating each 15 minutes of exercise by an “energy cube”. Based on collaboration between pilots, teachers and policymakers, this project is implemented over a 6-week period in schools, municipalities and recreation centres. “Great Challenge” events are organized to promote PA. The GLMC is also a theory-based intervention based on the tenets of the planned behaviour theory.Results: Since the 2014-2015 edition, 2,243 children have taken part in the GLMC and have accumulated 391,102 “energy cubes”. In addition, more than 30 “Great Challenge” events have been organized. Since its launch during the 2012-2013 school year, the numbers of children who have taken part in the GLMC have been multiplied by 5.58. The mean number of daily “energy cubes” accumulated by children has increased from 4.04 in the first year to 6.22 in 2014-2015.Conclusion: The “energy cube” can provide a measure of the commitment of children and their surrounding community in a comprehensive approach to PA promotion.

  9. Bayer-activities of daily living scale in mild and moderate dementia of the Alzheimer type.

    PubMed

    Nagaratnam, Nages; Nagaratnam, Kujan; O'Mara, Deborah

    2013-12-01

    The main purpose of this study is to examine the reliability of the Bayer-Activities of Daily Living (B-ADL) scale when used as a cognitive screening instrument for mild and moderate dementia of the Alzheimer type. This is a retrospective study of 66 patients with dementia. The B-ADL scale was completed by the caregiver or the family member at the first encounter. The internal consistency was found to be 0.94 for the 27 patients that completed all 25 questions in the scale. Significant correlation and receiver-operating characteristic curve analysis were found for the B-ADL total score and subscale 1 (tasks requiring short- and long-term memory) for Clinical Dementia Rating scale. Severity of dementia by the B-ADL scale is statistically similar but not the same as Mini-Mental State Examination. Our findings confirm that B-ADL scale is a valid indicator of the cognitive status of patients with Alzheimer's disease.

  10. UPDRS activity of daily living score as a marker of Parkinson's disease progression.

    PubMed

    Harrison, Madaline B; Wylie, Scott A; Frysinger, Robert C; Patrie, James T; Huss, Diane S; Currie, Lillian J; Wooten, G Frederick

    2009-01-30

    The activities of daily living (ADL) subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) captures the impact of Parkinson's disease (PD) on daily function and may be less affected than other subsections by variability associated with drug cycle and motor fluctuations. We examined UPDRS mentation, ADL and motor subscores in 888 patients with idiopathic PD. Multiple linear regression analyses determined the association between disease duration and UPDRS subscores as a function of medication status at examination and in a subset of patients with multiple examinations. Independent of medication status and across cross-sectional and longitudinal analyses, ADL subscores showed a stronger and more stable association with disease duration than other UPDRS subscores after adjusting for age of disease onset. The association between disease duration and the motor subscore depended on medication status. The strong association between ADL subscore and disease duration in PD suggests that this measure may serve as a better marker of disease progression than signs and symptoms assessed in other UPDRS sections.

  11. Standardized training tools for the UPDRS activities of daily living scale: newly available teaching program.

    PubMed

    Goetz, Christopher G; LeWitt, Peter A; Weidenman, Meredith

    2003-12-01

    The Unified Parkinson's Disease Rating Scale (UPDRS) is the most widely used scale for evaluation of clinical impairment in PD. Whereas the motor section has been studied intensively for clinimetric properties and has an associated training tape, the Activities of Daily Living (ADL) section has been studied less rigorously. In preparation for a multicenter study that planned to use the UPDRS ADL score as an outcome, the authors reviewed the UPDRS ADL scale and designed a teaching program to provide a uniform technique for data acquisition without changing any wording of the primary scale. The teaching program is composed of four components: overall guidelines, clarifying points, recommended strategies, and a teaching videotape. The videotape shows examples of interviewers assessing each ADL item with patients of different disability levels and provides a complete ADL assessment of a single patient. Systematic training and utilization of this teaching program offer the potential for more uniformity in results of ADL assessments conducted in clinical practice and multicenter, international studies of PD. The written materials and videotape belong to the Movement Disorder Society and are available by contacting the MDS central office.

  12. Is surviving enough? Coping and impact on activities of daily living among melanoma patients with lymphoedema.

    PubMed

    Cromwell, K D; Chiang, Y J; Armer, J; Heppner, P P; Mungovan, K; Ross, M I; Gershenwald, J E; Lee, J E; Royal, R E; Lucci, A; Cormier, J N

    2015-09-01

    We assessed the impact of lymphoedema (defined as ≥ 10% limb volume change) on quality of life (QOL), ability to perform activities of daily living (ADLs) and coping in 277 melanoma patients. Limb volume was measured prospectively, pre-operatively and every 3-6 months for 18 months post-operatively using a perometer. Three questionnaires were administered to measure QOL, coping and impact on ADLs. Statistical analyses were conducted using longitudinal logistic regression models. At 18 months, the cumulative incidence of lymphoedema was 31% in patients with upper extremity nodal basin treatment and 40% in lower extremity nodal basin treatment patients. Patients with lower extremity lymphoedema reported lower QOL scores than those with upper extremity lymphoedema. Over 18 months, both groups with mild and moderate lymphoedema showed improvement in coping [odds ratio (OR): 6.67, 95% confidence interval (CI): 3.30-13.47] and performance of ADLs (OR: 7.46, CI: 3.38-16.47). Over the course of 18 months, men were found to have poorer coping scores than women (OR: 2.91, CI: 1.35-6.27). Lymphoedema was associated with improvement in coping over time (P = 0.08) and a higher reported interference with ADLs (OR: 2.53, CI: 1.29-4.97). Patient education about lymphoedema at the time of surgical consent may improve self-efficacy and coping ability. Effective management of lymphoedema may improve patient QOL and reduce interference with ADLs.

  13. Recognition-mediated activation of therapeutic gold nanoparticles inside living cells

    NASA Astrophysics Data System (ADS)

    Kim, Chaekyu; Agasti, Sarit S.; Zhu, Zhengjiang; Isaacs, Lyle; Rotello, Vincent M.

    2010-11-01

    Supramolecular chemistry provides a versatile tool for the organization of molecular systems into functional structures and the actuation of these assemblies for applications through the reversible association between complementary components. Use of this methodology in living systems, however, represents a significant challenge owing to the chemical complexity of cellular environments and lack of selectivity of conventional supramolecular interactions. Herein, we present a host-guest system featuring diaminohexane-terminated gold nanoparticles (AuNP-NH2) and complementary cucurbit[7]uril (CB[7]). In this system, threading of CB[7] on the particle surface reduces the cytotoxicity of AuNP-NH2 through sequestration of the particle in endosomes. Intracellular triggering of the therapeutic effect of AuNP-NH2 was then achieved through the administration of 1-adamantylamine (ADA), removing CB[7] from the nanoparticle surface, causing the endosomal release and concomitant in situ cytotoxicity of AuNP-NH2. This supramolecular strategy for intracellular activation provides a new tool for potential therapeutic applications.

  14. Activities of daily living, depression, and social support among elderly Turkish people.

    PubMed

    Bozo, Ozlem; Toksabay, N Ece; Kürüm, Oya

    2009-03-01

    The authors examined the effects of activities of daily living (ADL) and perceived social support on the level of depression among elderly Turkish people. Participants were 102 adults older than the age of 60 years. The authors hypothesized that (a) lower levels of ADL would predict a higher level of depression, (b) a higher level of perceived social support would predict a lower level of depression, and (c) perceived social support would moderate the relation between ADL and depression. Although hierarchical multiple regression analysis did not yield a significant effect for an ADL-perceived social support interaction, ADL and perceived social support significantly predicted depression among elderly people. Thus, perceived social support did not moderate the relation between ADL and depression among elderly people; however, higher ADL functioning and higher perceived social support predicted lower depression. The nonsignificant effect of an ADL-perceived social support interaction on the level of depression among elderly people was incongruent with the stress-buffering model (S. Cohen & T. A. Willis, 1985). The authors discuss the strengths, limitations, and possible implications of the findings.

  15. Biomechanical Characteristics of Hand Coordination in Grasping Activities of Daily Living.

    PubMed

    Liu, Ming-Jin; Xiong, Cai-Hua; Xiong, Le; Huang, Xiao-Lin

    2016-01-01

    Hand coordination can allow humans to have dexterous control with many degrees of freedom to perform various tasks in daily living. An important contributing factor to this important ability is the complex biomechanical architecture of the human hand. However, drawing a clear functional link between biomechanical architecture and hand coordination is challenging. It is not understood which biomechanical characteristics are responsible for hand coordination and what specific effect each biomechanical characteristic has. To explore this link, we first inspected the characteristics of hand coordination during daily tasks through a statistical analysis of the kinematic data, which were collected from thirty right-handed subjects during a multitude of grasping tasks. Then, the functional link between biomechanical architecture and hand coordination was drawn by establishing the clear corresponding causality between the tendinous connective characteristics of the human hand and the coordinated characteristics during daily grasping activities. The explicit functional link indicates that the biomechanical characteristic of tendinous connective architecture between muscles and articulations is the proper design by the Creator to perform a multitude of daily tasks in a comfortable way. The clear link between the structure and the function of the human hand also suggests that the design of a multifunctional robotic hand should be able to better imitate such basic architecture.

  16. A robotic system to train activities of daily living in a virtual environment.

    PubMed

    Guidali, Marco; Duschau-Wicke, Alexander; Broggi, Simon; Klamroth-Marganska, Verena; Nef, Tobias; Riener, Robert

    2011-10-01

    In the past decade, several arm rehabilitation robots have been developed to assist neurological patients during therapy. Early devices were limited in their number of degrees of freedom and range of motion, whereas newer robots such as the ARMin robot can support the entire arm. Often, these devices are combined with virtual environments to integrate motivating game-like scenarios. Several studies have shown a positive effect of game-playing on therapy outcome by increasing motivation. In addition, we assume that practicing highly functional movements can further enhance therapy outcome by facilitating the transfer of motor abilities acquired in therapy to daily life. Therefore, we present a rehabilitation system that enables the training of activities of daily living (ADL) with the support of an assistive robot. Important ADL tasks have been identified and implemented in a virtual environment. A patient-cooperative control strategy with adaptable freedom in timing and space was developed to assist the patient during the task. The technical feasibility and usability of the system was evaluated with seven healthy subjects and three chronic stroke patients.

  17. Disaggregating Activities of Daily Living Limitations for Predicting Nursing Home Admission

    PubMed Central

    Fong, Joelle H; Mitchell, Olivia S; Koh, Benedict S K

    2015-01-01

    Objective To examine whether disaggregated activities of daily living (ADL) limitations better predict the risk of nursing home admission compared to conventionally used ADL disability counts. Data Sources We used panel data from the Health and Retirement Study (HRS) for years 1998–2010. The HRS is a nationally representative survey of adults older than 50 years (n = 18,801). Study Design We fitted Cox regressions in a continuous time survival model with age at first nursing home admission as the outcome. Time-varying ADL disability types were the key explanatory variables. Principal Findings Of the six ADL limitations, bathing difficulty emerged as the strongest predictor of subsequent nursing home placement across cohorts. Eating and dressing limitations were also influential in driving admissions among more recent cohorts. Using simple ADL counts for analysis yielded similar adjusted R2s; however, the amount of explained variance doubled when we allowed the ADL disability measures to time-vary rather than remain static. Conclusions Looking beyond simple ADL counts can provide health professionals insights into which specific disability types trigger long-term nursing home use. Functional disabilities measured closer in time carry more prognostic power than static measures. PMID:25256014

  18. Prevalence of headache and its interference in the activities of daily living in female adolescent students

    PubMed Central

    Lima, Alaine Souza; de Araújo, Rodrigo Cappato; Gomes, Mayra Ruana de A.; de Almeida, Ludmila Remígio; de Souza, Gabriely Feitosa F.; Cunha, Samara Barreto; Pitangui, Ana Carolina R.

    2014-01-01

    OBJECTIVE: To describe the prevalence of headache and its interference in the activities of daily living (ADL) in female adolescent students. METHODS: This descriptive cross-sectional study enrolled 228 female adolescents from a public school in the city of Petrolina, Pernambuco, Northeast Brazil, aged ten to 19 years. A self-administered structured questionnaire about socio-demographic characteristics, occurrence of headache and its characteristics was employed. Headaches were classified according to the International Headache Society criteria. The chi-square test was used to verify possible associations, being significant p<0.05. RESULTS: After the exclusion of 24 questionnaires that did not met the inclusion criteria, 204 questionnaires were analyzed. The mean age of the adolescents was 14.0±1.4 years. The prevalence of headache was 87.7%. Of the adolescents with headache, 0.5% presented migraine without pure menstrual aura; 6.7%, migraine without aura related to menstruation; 1.6%, non-menstrual migraine without aura; 11.7%, tension-type headache and 79.3%, other headaches. Significant associations were found between pain intensity and the following variables: absenteeism (p=0.001); interference in ADL (p<0.001); medication use (p<0.001); age (p=0.045) and seek for medical care (p<0.022). CONCLUSIONS: The prevalence of headache in female adolescents observed in this study was high, with a negative impact in ADL and school attendance. PMID:25119759

  19. Emotion, social functioning and activities of daily living in frontotemporal dementia.

    PubMed

    Kipps, Christopher M; Mioshi, Eneida; Hodges, John R

    2009-06-01

    Social functioning in FTD is profoundly affected, and forms the basis for the clinical diagnosis of the behavioural variant of the disease (bv-FTD). In particular, there are deficits in emotional processing, but the inter-relationship of such deficits to other aspects of social functioning remains unclear. We studied patients with bv-FTD (n = 14) and AD (n = 14), and compared their performance on a test of emotion recognition with their scores on two carer-based assessments: the Disability Assessment for Dementia (DAD) of activities in daily living (ADL), and the Cambridge Behavioural Inventory (CBI). The bv-FTD group had significantly greater impairments in ADLs, and had higher scores on the CBI, compared to the AD group. Despite a deficit in emotion recognition, particularly involving negative emotions, in the FTD group relative to AD and controls, performance on this task did not correlate with ADL ratings which instead, correlated highly with carer-rated apathy levels on the CBI. The study highlights the multifactorial nature of social dysfunction in FTD which is important in the management of these patients and in designing effective behavioural and therapeutic interventions. The relationship of emotional processing to other aspects of social cognition in FTD is reviewed.

  20. Trunk angular kinematics during slip-induced backward falls and activities of daily living.

    PubMed

    Liu, Jian; Lockhart, Thurmon E

    2014-10-01

    Prior to developing any specific fall detection algorithm, it is critical to distinguish the unique motion features associated with fall accidents. The current study aimed to investigate the upper trunk angular kinematics during slip-induced backward falls and activities of daily living (ADLs). Ten healthy older adults (age = 75 ± 6 yr (mean ± SD)) were involved in a laboratory study. Sagittal trunk angular kinematics were measured using optical motion analysis system during normal walking, slip-induced backward falls, lying down, bending over, and various types of sitting down (SN). Trunk angular phase-plane plots were generated to reveal the motion features of falls. It was found that backward falls were characterized by a simultaneous occurrence of a slight trunk extension and an extremely high trunk extension velocity (peak average = 139.7 deg/s), as compared to ADLs (peak average = 84.1 deg/s). It was concluded that the trunk extension angular kinematics of falls were clearly distinguishable from those of ADLs from the perspective of angular phase-plane plot. Such motion features can be utilized in future studies to develop a new prior-to-impact fall detection algorithm.

  1. An introductory study of common grasps used by adults during performance of activities of daily living.

    PubMed

    Vergara, Margarita; Sancho-Bru, J L; Gracia-Ibáñez, V; Pérez-González, A

    2014-01-01

    This paper presents the results of a descriptive survey on human grasps. Sixty-four videos were selected to represent tasks performed in the main areas of activities of daily living (ADL) (personal care, meal preparation, eating, housekeeping, etc.). All the participants were right-handed. Elementary grasps were identified for each hand, and the grasp type (from a 9-type classification), the hands involved, and the duration were registered for each case. The results show that the most commonly used grasps are: pinch, non-prehensile, cylindrical, lateral pinch and lumbrical. The presence of these grasps in the areas of ADL is, however, very different (e.g., pinch is widely used in food preparation and very little in driving). Some grasps were used more frequently with one hand or when both hands were used simultaneously (e.g., special pinch was hardly used by the left hand). Knowing the grasp types most frequently used in ADL is essential to be able to assess grasp rehabilitation processes or hand prostheses development.

  2. Live diatom silica immobilization of multimeric and redox-active enzymes.

    PubMed

    Sheppard, V C; Scheffel, A; Poulsen, N; Kröger, N

    2012-01-01

    Living organisms are adept in forming inorganic materials (biominerals) with unique structures and properties that exceed the capabilities of engineered materials. Biomimetic materials syntheses are being developed that aim at replicating the advantageous properties of biominerals in vitro and endow them with additional functionalities. Recently, proof-of-concept was provided for an alternative approach that allows for the production of biomineral-based functional materials in vivo. In this approach, the cellular machinery for the biosynthesis of nano-/micropatterned SiO₂ (silica) structures in diatoms was genetically engineered to incorporate a monomeric, cofactor-independent ("simple") enzyme, HabB, into diatom silica. In the present work, it is demonstrated that this approach is also applicable for enzymes with "complex" activity requirements, including oligomerization, metal ions, organic redox cofactors, and posttranslational modifications. Functional expression of the enzymes β-glucuronidase, glucose oxidase, galactose oxidase, and horseradish peroxidase in the diatom Thalassiosira pseudonana was accomplished, and 66 to 78% of the expressed enzymes were stably incorporated into the biosilica. The in vivo incorporated enzymes represent approximately 0.1% (wt/wt) of the diatom biosilica and are stabilized against denaturation and proteolytic degradation. Furthermore, it is demonstrated that the gene construct for in vivo immobilization of glucose oxidase can be utilized as the first negative selection marker for diatom genetic engineering.

  3. Relationship between Brazilian adolescents' physical activity and social and economic indicators of the cities where they live.

    PubMed

    Silva, Diego A S

    2015-04-01

    This study investigated the relationship between sufficient amounts of physical activity among Brazilian adolescents and the economic and social indicators of the cities where they live. Data from a large national survey including 109,104 boys and girls ages 13 to 15 yr. (47.8% boys, 52.2% girls) were analyzed. The economic and social indicators were the Human Development Index (HDI), which is a comparative measure to rank cities according to their degree of human development, the Gini index (income inequality), population density, and maternal education. Stepwise regression was used to identify associations between physical activity and economic and social indicators of the cities. The physical activity of Brazilian adolescents was associated with the social and economic conditions of the cities where they live. The amount of physical activity of girls was greater in the cities with fewer income inequalities. For boys, physical activity was greater in the cities with a higher HDI and fewer income inequalities.

  4. IAU Project and Research Activity in Nepal

    NASA Astrophysics Data System (ADS)

    Gautam, Suman

    2015-08-01

    The second half of the twentieth century has witnessed a tremendous development in the field of astronomy and space exploration. The large telescope both on the land and in the orbit, using the whole range of the electromagnetic spectra from radio waves to gamma rays are extending their range of exploration, right to the edge of the observable universe, and making astounding discoveries in the process. Many large international telescope facilities and global plans are accessible to all astronomers throughout the world, providing an inexpensive entry to cutting- edge international research for developing countries.Nepal is a mountainous country it has a wide range of climatic and altitude variations which varies from an elevation of 200 meter to ≥ 4000 meter. The average temperature varies from ≥ 25 o C to ≤ 0 to 5oC. Because of these diverse weather and climatic variation there is the potential for the establishment of sophisticated observatory/ data centre and link with each other. So, the future possible opportunity of astronomy in Nepal will be discussed. Besides Education and Research activities conducted in Tribhuvan University, Nepal under the support of International Astronomical Union (IAU) will also be highlighted. The importance brought by those two workshops conducted on data simulation supported by IAU under TF1 will also be discussed which is believed to play a vital role for the promotion and development of astronomy and astrophysics in developing countries.

  5. Estimation of Physical Activity Energy Expenditure during Free-Living from Wrist Accelerometry in UK Adults

    PubMed Central

    Westgate, Kate; Wareham, Nicholas J.; Brage, Soren

    2016-01-01

    Background Wrist-worn accelerometers are emerging as the most common instrument for measuring physical activity in large-scale epidemiological studies, though little is known about the relationship between wrist acceleration and physical activity energy expenditure (PAEE). Methods 1695 UK adults wore two devices simultaneously for six days; a combined sensor and a wrist accelerometer. The combined sensor measured heart rate and trunk acceleration, which was combined with a treadmill test to yield a signal of individually-calibrated PAEE. Multi-level regression models were used to characterise the relationship between the two time-series, and their estimations were evaluated in an independent holdout sample. Finally, the relationship between PAEE and BMI was described separately for each source of PAEE estimate (wrist acceleration models and combined-sensing). Results Wrist acceleration explained 44–47% between-individual variance in PAEE, with RMSE between 34–39 J•min-1•kg-1. Estimations agreed well with PAEE in cross-validation (mean bias [95% limits of agreement]: 0.07 [-70.6:70.7]) but overestimated in women by 3% and underestimated in men by 4%. Estimation error was inversely related to age (-2.3 J•min-1•kg-1 per 10y) and BMI (-0.3 J•min-1•kg-1 per kg/m2). Associations with BMI were similar for all PAEE estimates (approximately -0.08 kg/m2 per J•min-1•kg-1). Conclusions A strong relationship exists between wrist acceleration and PAEE in free-living adults, such that irrespective of the objective method of PAEE assessment, a strong inverse association between PAEE and BMI was observed. PMID:27936024

  6. Tobacco control among disadvantaged youth living in low-income communities in India: Introducing Project ACTIVITY

    PubMed Central

    Stigler, Melissa; Gupta, Vinay; Bassi, Shalini; Dhavan, Poonam; Mathur, Neha; Tripathy, Vikal; Perry, Cheryl; Reddy, K. Srinath

    2010-01-01

    Objective To provide an overview of Project ACTIVITY, a group randomized intervention trial designed to test the efficacy of a community-based, comprehensive approach to tobacco control for youth (10-19 years) living in low-income communities in India. In doing so, details regarding baseline characteristics of the study sample are provided. Methods Fourteen slum communities in Delhi, India were matched and randomized to intervention (n=7) and control (n=7) conditions. The intervention included multiple strategies to promote prevention and cessation of tobacco use among youth. A census was conducted in selected blocks in all study communities (n=78,133), as well as a baseline survey of eligible youth (n=6,023). Main outcomes measures on the survey included ever use, past six months use and current use of multiple forms of tobacco. Mixed effects regression models were used to examine differences between study conditions in (a) demographic characteristics and (b) the prevalence of tobacco consumption. Results Census data revealed that 31.9% of sampled population was in the age group of 10-19 years. No differences between study conditions in demographic characteristics (e.g. age, gender, religion, education, and occupation) among either adults or youth were noted (p>0.05). The baseline survey data revealed the prevalence of ever tobacco use among youth was 7.99%, past six months use was 5.70%, and current use was 4.88%. No differences between study conditions in these prevalence rates were observed, either (p>0.05). Conclusion The two study conditions in Project ACTIVITY are comparable. The evaluation should provide a robust test of this intervention's efficacy. PMID:20593929

  7. GroEL and Lipopolysaccharide from Francisella tularensis Live Vaccine Strain Synergistically Activate Human Macrophages ▿

    PubMed Central

    Noah, Courtney E.; Malik, Meenakshi; Bublitz, DeAnna C.; Camenares, Devin; Sellati, Timothy J.; Benach, Jorge L.; Furie, Martha B.

    2010-01-01

    Francisella tularensis, the causative agent of tularemia, interacts with host cells of innate immunity in an atypical manner. For most Gram-negative bacteria, the release of lipopolysaccharide (LPS) from their outer membranes stimulates an inflammatory response. When LPS from the attenuated live vaccine strain (LVS) or the highly virulent Schu S4 strain of F. tularensis was incubated with human umbilical vein endothelial cells, neither species of LPS induced expression of the adhesion molecule E-selectin or secretion of the chemokine CCL2. Moreover, a high concentration (10 μg/ml) of LVS or Schu S4 LPS was required to stimulate production of CCL2 by human monocyte-derived macrophages (huMDM). A screen for alternative proinflammatory factors of F. tularensis LVS identified the heat shock protein GroEL as a potential candidate. Recombinant LVS GroEL at a concentration of 10 μg/ml elicited secretion of CXCL8 and CCL2 by huMDM through a TLR4-dependent mechanism. When 1 μg of LVS GroEL/ml was added to an equivalent amount of LVS LPS, the two components synergistically activated the huMDM to produce CXCL8. Schu S4 GroEL was less stimulatory than LVS GroEL and showed a lesser degree of synergy when combined with Schu S4 LPS. These findings suggest that the intrinsically low proinflammatory activity of F. tularensis LPS may be increased in the infected human host through interactions with other components of the bacterium. PMID:20123721

  8. Production of functional active human growth factors in insects used as living biofactories.

    PubMed

    Dudognon, Benoit; Romero-Santacreu, Lorena; Gómez-Sebastián, Silvia; Hidalgo, Ana B; López-Vidal, Javier; Bellido, María L; Muñoz, Eduardo; Escribano, José M

    2014-08-20

    Growth factors (GFs) are naturally signalling proteins, which bind to specific receptors on the cell surface. Numerous families of GFs have already been identified and remarkable progresses have been made in understanding the pathways that these proteins use to activate/regulate the complex signalling network involved in cell proliferation or wound healing processes. The bottleneck for a wider clinical and commercial application of these factors relay on their scalable cost-efficient production as bioactive molecules. The present work describes the capacity of Trichoplusia ni insect larvae used as living bioreactors in combination with the baculovirus vector expression system to produce three fully functional human GFs, the human epidermal growth factor (huEGF), the human fibroblast growth factor 2 (huFGF2) and the human keratinocyte growth factor 1 (huKGF1). The expression levels obtained per g of insect biomass were of 9.1, 2.6 and 3mg for huEGF, huFGF2 and huKGF1, respectively. Attempts to increase the productivity of the insect/baculovirus system we have used different modifications to optimize their production. Additionally, recombinant proteins were expressed fused to different tags to facilitate their purification. Interestingly, the expression of huKGF1 was significantly improved when expressed fused to the fragment crystallizable region (Fc) of the human antibody IgG. The insect-derived recombinant GFs were finally characterized in terms of biological activity in keratinocytes and fibroblasts. The present work opens the possibility of a cost-efficient and scalable production of these highly valuable molecules in a system that favours its wide use in therapeutic or cosmetic applications.

  9. Toward real time detection of the basic living activity in home using a wearable sensor and smart home sensors.

    PubMed

    Bang, Sunlee; Kim, Minho; Song, Sa-Kwang; Park, Soo-Jun

    2008-01-01

    As the elderly people living alone are enormously increasing recently, we need the system inferring activities of daily living (ADL) for maintaining healthy life and recognizing emergency. The system should be constructed with sensors, which are used to associate with people's living while remaining as non intrusive views as possible. To do this, the proposed system use a triaxial accelerometer sensor and environment sensors indicating contact with subject in home. Particularly, in order to robustly infer ADLs, we present component ADL, which is decided with conjunction of human motion together, not just only contacted object identification. It is an important component in inferring ADL. In special, component ADL decision firstly refines misclassified initial activities, which improves the accuracy of recognizing ADL. Preliminary experiments results for proposed system provides overall recognition rate of over 97% over 8 component ADLs, which can be effectively applicable to recognize the final ADLs.

  10. Update on U.S.EPA Cookstove Research Activities

    EPA Science Inventory

    The presentation includes background information on EPA's stove research, focuses on cookstove testing for air pollutant emissions and energy efficiency, and briefly describes current research activities. Ongoing activities are highlighted, and EPA contacts are provided.

  11. Ignored Discovery now Proven Capable of Saving Millions of Lives from Premature Cancer Death Demands Rethinking the Direction of Research

    NASA Astrophysics Data System (ADS)

    Crosetto, Dario B.

    2008-06-01

    A discovery described in articles for the past ten years regarding the increase of 400 times efficiency over current PET has been validated by a third party (Siemens). Its importance lies in the possibility to save millions of lives from premature cancer death through early detection and use of low radiation enabling safe screening of high-risk patients. Because the discovery has been ignored for a decade and has now been validated, rethinking the direction of research is demanded. Technical-Scientific objectives should be consistent with social objectives. Grant assignments should be based on estimates and verification of the number of lives saved, cost per life saved, time to achieve those results and how well supported, with solid scientific arguments, is the research. A conservative estimated result is 100,000 lives saved per year in the U.S. alone at a cost less than half of the current $64 billion annual expense for cancer treatment: a cost to society of only $250,000 per additional life saved versus the current cost of $10 million. Benefits to the patient can be achieved immediately with no need to wait for additional discoveries. A plan to accelerate benefits to the patient is provided.

  12. Co-benefits of designing communities for active living: an exploration of literature.

    PubMed

    Sallis, James F; Spoon, Chad; Cavill, Nick; Engelberg, Jessa K; Gebel, Klaus; Parker, Mike; Thornton, Christina M; Lou, Debbie; Wilson, Amanda L; Cutter, Carmen L; Ding, Ding

    2015-02-28

    To reverse the global epidemic of physical inactivity that is responsible for more than 5 million deaths per year, many groups recommend creating "activity-friendly environments." Such environments may have other benefits, beyond facilitating physical activity, but these potential co-benefits have not been well described. The purpose of the present paper is to explore a wide range of literature and conduct an initial summary of evidence on co-benefits of activity-friendly environments. An extensive but non-systematic review of scientific and "gray" literature was conducted. Five physical activity settings were defined: parks/open space/trails, urban design, transportation, schools, and workplaces/buildings. Several evidence-based activity-friendly features were identified for each setting. Six potential outcomes/co-benefits were searched: physical health, mental health, social benefits, safety/injury prevention, environmental sustainability, and economics. A total of 418 higher-quality findings were summarized. The overall summary indicated 22 of 30 setting by outcome combinations showed "strong" evidence of co-benefits. Each setting had strong evidence of at least three co-benefits, with only one occurrence of a net negative effect. All settings showed the potential to contribute to environmental sustainability and economic benefits. Specific environmental features with the strongest evidence of multiple co-benefits were park proximity, mixed land use, trees/greenery, accessibility and street connectivity, building design, and workplace physical activity policies/programs. The exploration revealed substantial evidence that designing community environments that make physical activity attractive and convenient is likely to produce additional important benefits. The extent of the evidence justifies systematic reviews and additional research to fill gaps.

  13. Traversing the Chiasms of Lived Experiences: Phenomenological Illuminations for Practitioner Research

    ERIC Educational Resources Information Center

    Lukenchuk, Antonina

    2006-01-01

    This article juxtaposes Merleau-Ponty's phenomenology of sense perception and practitioner research as well as demonstrating their potential to become integrated into powerful educational research and practice. The paper elaborates on Merleau-Ponty's metaphor of "chiasm", extends its symbolic meaning to practitioner research and illustrates its…

  14. Effects of horse-riding exercise on balance, gait, and activities of daily living in stroke patients

    PubMed Central

    Kim, Yong-Nam; Lee, Dong-Kyu

    2015-01-01

    [Purpose] This study aimed to investigate the effects of horse-riding exercise on balance, gait, and activities of daily living (ADLs) in stroke patients. [Subjects] Among 20 participants with stroke, 10 were randomly assigned to the experimental group, and 10 were randomly assigned to the control group. The experimental group participated in horse-riding exercise for 30 minutes per day, 5 days a week for 6 weeks. Balance was tested with the Berg Balance Scale (BBS). Gait was measured using the 10-Meter Walk Test (10MWT). ADLs were tested with the Modified Barthel Index (MBI). Differences between pre- and post-experiment values within the two groups were compared using paired t-tests. Between-group differences were compared using independent t-tests. [Results] The experimental group showed significant improvements in balance, gait, and ADLs following horse-riding exercise. Additionally, the experimental group showed significant differences in balance, gait, and ADLs compared with in the control group. [Conclusion] These results support that horse-riding exercise enhances balance, gait, and ADLs in stroke patients. This study supports the need for further research on horse-riding exercise programs. PMID:25931690

  15. The effect of mirror therapy on upper-extremity function and activities of daily living in stroke patients

    PubMed Central

    Park, Jin-Young; Chang, Moonyoung; Kim, Kyeong-Mi; Kim, Hee-Jung

    2015-01-01

    The purpose of this study was to examine the effects of mirror therapy on upper-extremity function and activities of daily living in chronic stroke patients. [Subjects and Methods] Fifteen subjects were each assigned to a mirror therapy group and a sham therapy group. The Fugl-Meyer Motor Function Assessment and the Box and Block Test were performed to compare paretic upper-extremity function and hand coordination abilities. The functional independence measurement was conducted to compare abilities to perform activities of daily living. [Results] Paretic upper-extremity function and hand coordination abilities were significantly different between the mirror therapy and sham therapy groups. Intervention in the mirror therapy group was more effective than in the sham therapy group for improving the ability to perform activities of daily living. Self-care showed statistically significant differences between the two groups. [Conclusion] Mirror therapy is effective in improving paretic upper-extremity function and activities of daily living in chronic stroke patients. PMID:26180297

  16. Changes in Eating and Physical Activity Behaviors across Seven Semesters of College: Living on or off Campus Matters

    ERIC Educational Resources Information Center

    Small, Meg; Bailey-Davis, Lisa; Morgan, Nicole; Maggs, Jennifer

    2013-01-01

    The transition from adolescence to adulthood is an important period for establishing behavioral patterns that affect long-term health and chronic disease risk. Nelson and colleagues speculated that developmental changes and changes in living situation may play an important role in the nutrition and physical activity behaviors of college students.…

  17. Health Education and Physical Education (Healthy, Active Living). Grades 5 and 9. Assessment Annotations for the Curriculum Frameworks.

    ERIC Educational Resources Information Center

    Missouri State Dept. of Elementary and Secondary Education, Jefferson City.

    This document provides supplemental assessment information to "Missouri's Framework for Curriculum Development in Health Education and Physical Education (Healthy, Active Living) K-12." The assessment annotations found in the third column of this document are intended to provide information for administrators, curriculum directors, and…

  18. From Passive to Active Learners: The "Lived Experience" of Nurses in a Specialist Nephrology Nursing Education Programme

    ERIC Educational Resources Information Center

    Bridger, Jane

    2007-01-01

    Purpose: This study aims to explore the lived experience of learning for a group of staff nurses in the Middle East, who undertook a post-registration nursing education programme in the speciality of nephrology nursing (the NNP) between 2001 and 2002. The broad-based curriculum seeks to develop the staff nurses into active learners, able to…

  19. Examining Success of Communication Strategies Used by Formal Caregivers Assisting Individuals with Alzheimer's Disease during an Activity of Daily Living

    ERIC Educational Resources Information Center

    Wilson, Rozanne; Rochon, Elizabeth; Mihailidis, Alex; Leonard, Carol

    2012-01-01

    Purpose: To examine how formal (i.e., employed) caregivers' use verbal and nonverbal communication strategies while assisting individuals with moderate to severe Alzheimer's disease (AD) during the successful completion of an activity of daily living (ADL). Based on the literature, the authors hypothesized that caregivers' use of 1 proposition,…

  20. Contribution of abdominal muscle strength to various activities of daily living of stroke patients with mild paralysis.

    PubMed

    Fujita, Takaaki; Sato, Atsushi; Togashi, Yui; Kasahara, Ryuichi; Ohashi, Takuro; Yamamoto, Yuichi

    2015-03-01

    [Purpose] The trunk muscles frequently become weak after stroke, thus impacting overall activities of daily living. However, activities of daily living items closely related with trunk strength remain unclear. This study aimed to clarify the influence of trunk muscle weakness on activities of daily living items. [Subjects] The subjects were 24 stroke patients who fulfilled the following inclusion criteria: first stroke and the absence of severe paralysis, marked cognitive function deterioration, unilateral spatial neglect or apathy. [Methods] According to abdominal strength, the 24 patients were divided into a nonweakness group and a weakness group. For the assessment, we used the stroke impairment assessment set, the Berg balance scale, a simple test for evaluating hand function, grip strength, and functional independence measure scale scores and the results were compared between the groups. [Results] The Berg balance scale score and scores for dressing, toilet use, transfer to bed, and walk items of the functional independence measure were significantly lower in the weakness group than in the nonweakness group. [Conclusion] Our results suggest that weakness of the abdominal muscles adversely impacts the balance of patients with mild stroke as well as their ability to dress, use a toilet, transfer, and walk. Trunk training, including abdominal muscle exercises, can effectively improve the performance of these activities of daily living items.

  1. What Might Work? Exploring the Perceived Feasibility of Strategies to Promote Physical Activity among Women Living in Socioeconomically Disadvantaged Neighbourhoods

    ERIC Educational Resources Information Center

    Cleland, Verity; Ball, Kylie

    2013-01-01

    This study aimed to investigate preferences for, perceived feasibility of and barriers to uptake of hypothetical physical activity promotion strategies among women from socioeconomically disadvantaged neighbourhoods. Semi-structured interviews were conducted with 20 purposively recruited women (18-45 years) living in socioeconomically…

  2. A Profile of Adults Needing Assistance with Activities of Daily Living, 1991-1992. Disability Statistics Report 11.

    ERIC Educational Resources Information Center

    Kennedy, Jae; LaPlante, Mitchell P.

    This report uses data from the 1990 and 1991 samples of the Survey of Income and Program Participation to construct a profile of the U.S. noninstitutionalized adult population needing assistance with activities of daily living (ADL) and to estimate the size of the population eligible for federal personal assistance services (PAS) under different…

  3. Live Healthy, Live Longer

    MedlinePlus

    ... Human Services. More Health News on: Exercise and Physical Fitness Health Screening Healthy Living Recent Health News Related MedlinePlus Health Topics Exercise and Physical Fitness Health Screening Healthy Living About MedlinePlus Site Map ...

  4. Consumer involvement in research projects: the activities of research funders.

    PubMed

    O'Donnell, Máire; Entwistle, Vikki

    2004-08-01

    This paper reports findings from a postal questionnaire survey and in-depth interviews with UK funders of health-related research that explored whether, why and how they promote consumer involvement in research projects. Many UK funders of health-related research are adopting a policy of promoting consumer involvement in research projects. Telephone interviews revealed they have several reasons for doing so, and that they vary in the ways they encourage and support researchers to involve consumers. For some, descriptions of consumer involvement in a research proposal are important for project funding decisions. They recognized a need for flexibility when assessing consumer involvement in different contexts. We suggest that funders should continue to work to clarify what they consider to be the parameters of acceptability in terms of consumer involvement and ensure that 'flexible' criteria are fairly applied. Researchers should be aware of particular funders' views when applying for project funding.

  5. 20 CFR 401.165 - Statistical and research activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Statistical and research activities. 401.165... RECORDS AND INFORMATION Disclosure of Official Records and Information § 401.165 Statistical and research activities. (a) General. Statistical and research activities often do not require information in a...

  6. 20 CFR 401.165 - Statistical and research activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Statistical and research activities. 401.165... RECORDS AND INFORMATION Disclosure of Official Records and Information § 401.165 Statistical and research activities. (a) General. Statistical and research activities often do not require information in a...

  7. 20 CFR 401.165 - Statistical and research activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Statistical and research activities. 401.165... RECORDS AND INFORMATION Disclosure of Official Records and Information § 401.165 Statistical and research activities. (a) General. Statistical and research activities often do not require information in a...

  8. 20 CFR 401.165 - Statistical and research activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Statistical and research activities. 401.165... RECORDS AND INFORMATION Disclosure of Official Records and Information § 401.165 Statistical and research activities. (a) General. Statistical and research activities often do not require information in a...

  9. 20 CFR 401.165 - Statistical and research activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Statistical and research activities. 401.165... RECORDS AND INFORMATION Disclosure of Official Records and Information § 401.165 Statistical and research activities. (a) General. Statistical and research activities often do not require information in a...

  10. Long Live Rock! Exploring Active Microbial Populations in North Pond Subsurface Basalt

    NASA Astrophysics Data System (ADS)

    Mills, H. J.; Lehne, J.

    2014-12-01

    Microbial life should be considered as an active source for subsurface alterations of crustal material. Over the past several decades, microbial populations have been qualitatively and quantitatively characterized in marine sediments from the near shore to gyre centers, from the surface to two kilometers below the surface. Recent exploration of the underlying basement has revealed bacterial populations within the basalt. Initial cultivation-based and in situ analysis of subsurface basalt has produced some structural identification of populations that have the potential to alter the crust. Within this study, we have advanced this understanding by characterizing the metabolically active fraction of these populations. A 16S rRNA gene transcript approach was conducted using high throughput sequencing on RNA extracted from breccia, glass basalts and ultramafic basalts of the western flank of the Mid-Atlantic Ridge. Previous research has shown that the fluid within the basement is oxic. As expected, populations associated with aerobic metabolism were detected. In addition, iron-utilizing populations were observed to be metabolically active within the basalt samples characterized. Future characterization will reveal overlap between previous studies to determine the total versus metabolically active populations.

  11. [Research on living tree volume forecast based on PSO embedding SVM].

    PubMed

    Jiao, You-Quan; Feng, Zhong-Ke; Zhao, Li-Xi; Xu, Wei-Heng; Cao, Zhong

    2014-01-01

    In order to establish volume model,living trees have to be fallen and be divided into many sections, which is a kind of destructive experiment. So hundreds of thousands of trees have been fallen down each year in China. To solve this problem, a new method called living tree volume accurate measurement without falling tree was proposed in the present paper. In the method, new measuring methods and calculation ways are used by using photoelectric theodolite and auxiliary artificial measurement. The diameter at breast height and diameter at ground was measured manually, and diameters at other heights were obtained by photoelectric theodolite. Tree volume and height of each tree was calculated by a special software that was programmed by the authors. Zhonglin aspens No. 107 were selected as experiment object, and 400 data records were obtained. Based on these data, a nonlinear intelligent living tree volume prediction model with Particle Swarm Optimization algorithm based on support vector machines (PSO-SVM) was established. Three hundred data records including tree height and diameter at breast height were randomly selected form a total of 400 data records as input data, tree volume as output data, using PSO-SVM tool box of Matlab7.11, thus a tree volume model was obtained. One hundred data records were used to test the volume model. The results show that the complex correlation coefficient (R2) between predicted and measured values is 0. 91, which is 2% higher than the value calculated by classic Spurr binary volume model, and the mean absolute error rates were reduced by 0.44%. Compared with Spurr binary volume model, PSO-SVM model has self-learning and self-adaption ability,moreover, with the characteristics of high prediction accuracy, fast learning speed,and a small sample size requirement, PSO-SVM model with well prospect is worth popularization and application.

  12. Instrumental activation analysis of coal and fly ash with thermal and epithermal neutrons and short-lived nuclides

    USGS Publications Warehouse

    Steinnes, E.; Rowe, J.J.

    1976-01-01

    Instrumental neutron activation analysis is applied to the determination of about 25 elements in coals and fly ash by means of nuclides with half-lives of less than 48 h ; thermal and epithermal irradiations are used. The results indicate that epithermal activation is preferable for twelve of the elements (Ga, As, Br, Sr, In, Cs, Ba, La, Sm, Ho, W and U). Data for SRM 1632 (coal) and SRM 1633 (fly ash) compare favorably with the results obtained by other investigators. ?? 1976.

  13. Physical Activity and Sport in the Lives of Girls. Physical & Mental Health Dimensions from an Interdisciplinary Approach.

    ERIC Educational Resources Information Center

    Minnesota Univ., Minneapolis. Center for Research on Girls and Women in Sport.

    This report highlights relevant research and expert opinion on girls' involvement in physical activity and sport. Research findings revealed: (1) more girls are participating in a wider array of physical activities than ever before; (2) regular physical activity in adolescence can reduce risk for obesity and hyperlipidemia, increase bone mass and…

  14. Kameleon Live: An Interactive Cloud Based Analysis and Visualization Platform for Space Weather Researchers

    NASA Astrophysics Data System (ADS)

    Pembroke, A. D.; Colbert, J. A.

    2015-12-01

    The Community Coordinated Modeling Center (CCMC) provides hosting for many of the simulations used by the space weather community of scientists, educators, and forecasters. CCMC users may submit model runs through the Runs on Request system, which produces static visualizations of model output in the browser, while further analysis may be performed off-line via Kameleon, CCMC's cross-language access and interpolation library. Off-line analysis may be suitable for power-users, but storage and coding requirements present a barrier to entry for non-experts. Moreover, a lack of a consistent framework for analysis hinders reproducibility of scientific findings. To that end, we have developed Kameleon Live, a cloud based interactive analysis and visualization platform. Kameleon Live allows users to create scientific studies built around selected runs from the Runs on Request database, perform analysis on those runs, collaborate with other users, and disseminate their findings among the space weather community. In addition to showcasing these novel collaborative analysis features, we invite feedback from CCMC users as we seek to advance and improve on the new platform.

  15. Prediction of ground reaction forces and moments during various activities of daily living.

    PubMed

    Fluit, R; Andersen, M S; Kolk, S; Verdonschot, N; Koopman, H F J M

    2014-07-18

    Inverse dynamics based simulations on musculoskeletal models is a commonly used method for the analysis of human movement. Due to inaccuracies in the kinematic and force plate data, and a mismatch between the model and the subject, the equations of motion are violated when solving the inverse dynamics problem. As a result, dynamic inconsistency will exist and lead to residual forces and moments. In this study, we present and evaluate a computational method to perform inverse dynamics-based simulations without force plates, which both improves the dynamic consistency as well as removes the model׳s dependency on measured external forces. Using the equations of motion and a scaled musculoskeletal model, the ground reaction forces and moments (GRF&Ms) are derived from three-dimensional full-body motion. The method entails a dynamic contact model and optimization techniques to solve the indeterminacy problem during a double contact phase and, in contrast to previously proposed techniques, does not require training or empirical data. The method was applied to nine healthy subjects performing several Activities of Daily Living (ADLs) and evaluated with simultaneously measured force plate data. Except for the transverse ground reaction moment, no significant differences (P>0.05) were found between the mean predicted and measured GRF&Ms for almost all ADLs. The mean residual forces and moments, however, were significantly reduced (P>0.05) in almost all ADLs using our method compared to conventional inverse dynamic simulations. Hence, the proposed method may be used instead of raw force plate data in human movement analysis using inverse dynamics.

  16. Validation of the Korean version of the Bayer activities of daily living scale.

    PubMed

    Choi, Seong Hye; Na, Duk L; Lee, Byung Hwa; Kang, Sue J; Ha, Choong-Kun; Han, Seol-Heui; Erzigkeit, Hellmut

    2003-08-01

    The Bayer-activities of daily living (B-ADL) is a brief and internationally applicable ADL instrument which has been validated in three European countries. The B-ADL has been developed to provide a tool for the assessment of functional deficits in performance of every day tasks as they are observed in mild to moderate stages of dementia. The B-ADL has been constructed for use in clinical trials as well as in clinical practice. From an international perspective the major application is the evaluation of treatment effects in clinical studies and the current study was to validate the Korean version of the B-ADL. The B-ADL was administered to a total of 129 subjects with varying degrees of cognitive decline. A substantial cross-sectional correlation between B-ADL and MMSE scores was found. The internal consistency of B-ADL was above 0.98. A factor analysis revealed that a one factor solution accounted for most of the total variance. The B-ADL global score significantly increased as the severity of dementia, assessed by global deterioration scale increased from stage 1 to 5. Test-retest reliabilities of B-ADL global score and each item were very high. All of these results were very similar to those from three European countries except for the proportion of 'non-applicability' in some ADL items. These findings provide evidence that the Korean version of B-ADL can be useful not only for clinical purposes but also for international multicentre studies.

  17. Predictive Factors of Dependency in Activities of Daily Living Following Limb Trauma in the Elderly

    PubMed Central

    Safa, Azade; Masoudi Alavi, Negin; Abedzadeh-Kalahroudi, Masoumeh

    2016-01-01

    Background Traumatic injuries in the elderly often lead to permanent disabilities and long-term treatments that can adversely influence their activities of daily of living (ADL). The effect on ADL is an important outcome in elderly trauma. Objectives The present study was designed to evaluate the predictive factors of dependency in ADL following limb trauma in elderly referred to Shahid Beheshti Hospital, Kashan, Iran, in 2013. Patients and Methods This descriptive study was conducted on 200 traumatic patients admitted to the trauma emergency ward of Shahid Beheshti hospital in 2013. The questionnaire used in this study had three parts: demographic data, information related to trauma, and an independence scale of ADL (ISADL). The ISADL was completed in the emergency ward to declare pre-traumatic status; it was also completed one and three months after trauma. Statistical analysis was conducted by the t-test and analysis of variance (ANOVA). The repeated measure was used to study the trend of the ISADL and other demographic variables. The multiple regression analysis was also used to declare the predictive variables related to the ISADL. Results The study population consisted of 81 males (40.5%) and 119 females (59.5%). The participants’ average age was 70.57 ± 9.05 years. In total, 80.5% of the elderly were completely independent in ADL before trauma; this decreased to 13.5% one month after trauma. The repeated measure analysis showed a significant improvement in the ISADL three months after trauma. Gender, age, and education had significant interaction with the ISADL. The multiple regression analysis showed that type of trauma and location of injured organ had predictive values related to the ISADL, one and three months after trauma. The place and cause of trauma, and having surgery showed a significant relationship with the ISADL three months after trauma. Conclusions Many factors, such as gender, age, education, type of trauma, and location of injured organ

  18. Photovoice as a community-based participatory research method among women living with HIV/AIDS: ethical opportunities and challenges.

    PubMed

    Teti, Michelle; Murray, Cynthia; Johnson, LaShaune; Binson, Diane

    2012-10-01

    Photovoice is a method in which participants use photography to identify, express, and disseminate their experiences. We conducted photovoice projects with women living with HIV/AIDS (N=21) to explore opportunities and challenges associated with the method. Photovoice provided a means to achieve two key principles of ethical public health practice: It gives participants opportunities to define their health priorities, and facilitates participant empowerment. Ethical challenges that were encountered related to exposing, through photographs, one's identity as living with HIV/AIDS, illicit activities, and other people. We discuss lessons learned for future practice to maximize the ethical opportunities and manage the challenges associated with using photovoice as an HIV-related CBPR strategy.

  19. Examining the utility of a bite-count-based measure of eating activity in free-living human beings.

    PubMed

    Scisco, Jenna L; Muth, Eric R; Hoover, Adam W

    2014-03-01

    The obesity epidemic has triggered a need for novel methods for measuring eating activity in free-living settings. Here, we introduce a bite-count method that has the potential to be used in long-term investigations of eating activity. The purpose of our observational study was to describe the relationship between bite count and energy intake and determine whether there are sex and body mass index group differences in kilocalories per bite in free-living human beings. From October 2011 to February 2012, 77 participants used a wrist-worn device for 2 weeks to measure bite count during 2,975 eating activities. An automated self-administered 24-hour recall was completed daily to provide kilocalorie estimates for each eating activity. Pearson's correlation indicated a moderate, positive correlation between bite count and kilocalories (r=0.44; P<0.001) across all 2,975 eating activities. The average per-individual correlation was 0.53. A 2 (sex)×3 (body mass index group: normal, overweight, obese) analysis of variance indicated that men consumed 6 kcal more per bite than women on average. However, there were no body mass index group differences in kilocalories per bite. This was the longest study of a body-worn sensor for monitoring eating activity of free-living human beings to date, which highlights the strong potential for this method to be used in future, long-term investigations.

  20. Computers in the Lives of Our Children: The Legacy of Television Research.

    ERIC Educational Resources Information Center

    Chen, Milton

    This comparative examination considers a new era of research on children's learning. How children learn from microcomputers is studied, in light of research on children and television; and such issues are illuminated as how television and computers differ in their historical and economic contexts, how such differences affect their ability to serve…

  1. Conducting Action Research in Kenyan Primary Schools: A Narrative of Lived Experiences

    ERIC Educational Resources Information Center

    Otienoh, Ruth

    2015-01-01

    This paper is a narrative of my personal experiences of conducting action research in Kenyan primary schools. It highlights the opportunities, successes, challenges and dilemmas I encountered during the process: from the school hunting period, to the carrying out of the actual research in two schools, with four teachers. This study reveals that…

  2. Living Action Research in Course Design: Centering Participatory and Social Justice Principles and Practices

    ERIC Educational Resources Information Center

    Gardner, Morgan; Hammett, Roberta

    2014-01-01

    Action research (AR) courses provide openings in higher education to engage students, schools and communities in democratic and socially just ways within the contexts of research, classroom learning and broader social interactions. Such opportunities are strengthened when instructors design AR courses with the goal of enabling students to…

  3. Professing to Learn: Creating Tenured Lives and Careers in the American Research University

    ERIC Educational Resources Information Center

    Neumann, Anna

    2009-01-01

    Research, teaching, service, and public outreach--all are aspects of being a tenured professor. But this list of responsibilities is missing a central component: actual scholarly learning--disciplinary knowledge that faculty teach, explore in research, and share with the academic community. How do professors pursue such learning when they must…

  4. Life after hospital closure: users' views of living in residential 'resettlement' projects. A case study in consumer-led research.

    PubMed

    McCourt, Christine A.

    2000-09-01

    OBJECTIVE: To conduct a user-led and focused study of the views and experiences of former psychiatric hospital patients in community-based residential projects four years after hospital closure. The aims of the study were to assess residents' views about their current living arrangements, their opportunities to give their views and their interest in a formal user-group such as a residents' council or citizen advocacy scheme. DESIGN: A small-scale, qualitative study designed to enable users to voice their own views and experiences in their own words, conducted by a project group of psychiatric service users/survivors. SETTING AND PARTICIPANTS: All eight residential 're-provision' projects in the area were included, with a total potential sample of 65 residents. All residents were invited to take part and a total of 26 were interviewed, although a larger number of residents together with residential care staff took part in initial 'house' meetings to discuss the study. METHODS: Semi-structured, open-ended interviews with all residents willing to participate, researcher participation in 'house meetings', researchers' personal reflection and discussion. RESULTS AND CONCLUSIONS: On the whole, residents were content with community living arrangements and preferred these to hospital, although levels of satisfaction varied across different residential projects. Residents lacked awareness of rights to and means of voicing concerns and making choices about major issues in their lives. They showed greater interest in individualized rather than group advocacy. Ideally, research and evaluation, to be truly user-focused, should be long-term and continuous in order to involve participants more fully, and should anticipate the structures and processes needed to act on findings.

  5. The Elderly’s Independent Living in Smart Homes: A Characterization of Activities and Sensing Infrastructure Survey to Facilitate Services Development

    PubMed Central

    Ni, Qin; García Hernando, Ana Belén; de la Cruz, Iván Pau

    2015-01-01

    Human activity detection within smart homes is one of the basis of unobtrusive wellness monitoring of a rapidly aging population in developed countries. Most works in this area use the concept of “activity” as the building block with which to construct applications such as healthcare monitoring or ambient assisted living. The process of identifying a specific activity encompasses the selection of the appropriate set of sensors, the correct preprocessing of their provided raw data and the learning/reasoning using this information. If the selection of the sensors and the data processing methods are wrongly performed, the whole activity detection process may fail, leading to the consequent failure of the whole application. Related to this, the main contributions of this review are the following: first, we propose a classification of the main activities considered in smart home scenarios which are targeted to older people’s independent living, as well as their characterization and formalized context representation; second, we perform a classification of sensors and data processing methods that are suitable for the detection of the aforementioned activities. Our aim is to help researchers and developers in these lower-level technical aspects that are nevertheless fundamental for the success of the complete application. PMID:26007717

  6. Changing investment in activities and interests in elders' lives: theory and measurement.

    PubMed

    Adams, Kathryn Betts

    2004-01-01

    Socioemotional selectivity and gerotranscendence, newer theories with roots in the disengagement theory of aging, provided the theoretical framework for a new measure of perceived change in investment in a variety of pursuits. The 30-item Change in Activity and Interest Index (CAII) was given to a sample of 327 outpatients aged 65-94. Items with at least 30% decreased investment responses included Entertaining in my home, Concern with others' opinions, Shopping and buying things, and Attending social events with new people. Principal Components Analysis of the index with dichotomous recoding (less vs. more or same investment) resulted in four factors: Active Instrumental (AI), Social Intellectual (SI), Spiritual Concerns (SC), and Transcendence (TR). Support for socioemotional selectivity and gerotranscendence is evident in the reported increase of importance of SI pursuits, with concurrent decrease in importance of AI activities among these respondents. Zero-order correlations of component scores with study variables suggest that AI and SI are more clearly related to older age, functional impairment, and negative affect than are SC and TR. The CAII appears to tap several dimensions of change in interests; the index gives geriatric mental health practitioners and researchers a tool to measure an aspect of social development that has been neglected in gerontology.

  7. Monitoring activities of daily living based on wearable wireless body sensor network.

    PubMed

    Kańtoch, E; Augustyniak, P; Markiewicz, M; Prusak, D

    2014-01-01

    With recent advances in microprocessor chip technology, wireless communication, and biomedical engineering it is possible to develop miniaturized ubiquitous health monitoring devices that are capable of recording physiological and movement signals during daily life activities. The aim of the research is to implement and test the prototype of health monitoring system. The system consists of the body central unit with Bluetooth module and wearable sensors: the custom-designed ECG sensor, the temperature sensor, the skin humidity sensor and accelerometers placed on the human body or integrated with clothes and a network gateway to forward data to a remote medical server. The system includes custom-designed transmission protocol and remote web-based graphical user interface for remote real time data analysis. Experimental results for a group of humans who performed various activities (eg. working, running, etc.) showed maximum 5% absolute error compared to certified medical devices. The results are promising and indicate that developed wireless wearable monitoring system faces challenges of multi-sensor human health monitoring during performing daily activities and opens new opportunities in developing novel healthcare services.

  8. Harvard-MIT research program in short-lived radiopharmaceuticals. Progress report, March 1, 1983-February 29, 1984

    SciTech Connect

    Adelstein, S.J.; Brownell, G.L.

    1984-02-01

    This report describes research efforts towards the achievement of a clearer understanding of the solution chemistry of technetium in order to facilitate the design of future clinical agents labeled with Tc-99m, the development of new receptor binding radiopharmaceuticals for the in vivo assessment of insulin receptors and for imaging the adrenal medulla and the brain, the examination of the utility of monoclonal antibodies and liposomes in the design of radiopharmaceuticals for diagnosis and therapy, and the synthesis of short-lived positron-emitting radiopharmaceuticals for transverse imaging of regional physiological processes.

  9. Improving the Nutritional Resource Environment for Healthy Living Through Community-based Participatory Research

    PubMed Central

    Sloane, David C; Diamant, Allison L; Lewis, LaVonna B; Yancey, Antronette K; Flynn, Gwendolyn; Nascimento, Lori Miller; McCarthy, William J; Guinyard, Joyce Jones; Cousineau, Michael R

    2003-01-01

    OBJECTIVES To build health promotion capacity among community residents through a community-based participatory model, and to apply this model to study the nutritional environment of an urban area to better understand the role of such resources in residents' efforts to live a healthy life. DESIGN A multiphase collaborative study that inventoried selected markets in targeted areas of high African-American concentration in comparison with markets in a contrasting wealthier area with fewer African Americans. SETTING A community study set in the Los Angeles metropolitan area. PARTICIPANTS African-American community organizations and community residents in the target areas. INTERVENTIONS Two surveys of market inventories were conducted. The first was a single-sheet form profiling store conditions and the availability of a small selection of healthy foods. The second provided detailed information on whether the store offered fruit, vegetables, low-fat dairy products, dried goods and other items necessary for residents to consume a nutritious diet. RESULTS The targeted areas were significantly less likely to have important items for living a healthier life. The variety and quality of fresh fruit and vegetable produce was significantly lower in the target areas. Such products as 1% milk, skim milk, low-fat and nonfat cheese, soy milk, tofu, whole grain pasta and breads, and low-fat meat and poultry items were sig-nificantly less available. CONCLUSIONS Healthy food products were significantly less available in the target areas. The authors conclude from these results that the health disparities experienced by African-American communities have origins that extend beyond the health delivery system and individual behaviors inasmuch as adherence to the healthy lifestyle associated with low chronic disease risk is more difficult in resource-poor neighborhoods than in resource-rich ones. PMID:12848840

  10. Action Research as a Professional Development Activity

    ERIC Educational Resources Information Center

    West, Chad

    2011-01-01

    Reflective teachers are always searching for ways to improve their teaching. When this reflection becomes intentional and systematic, they are engaging in teacher research. This type of research, sometimes called "action research", can help bridge the gap between theory and practice by addressing topics that are relevant to practicing teachers.…

  11. Peer-led active tuberculosis case-finding among people living with HIV: lessons from Nepal

    PubMed Central

    Joshi, Dipu; Sthapit, Raisha

    2017-01-01

    Abstract Problem People living with a human immunodeficiency virus (HIV) infection have a high risk of tuberculosis and should undergo regular screening. However, they can be difficult to reach because they are stigmatized and discriminated against. Approach In Nepal, the nongovernmental organization Naya Goreto implemented a peer-led tuberculosis screening project in which people living with HIV volunteered to contact others in this high-risk population. Volunteers took part in a short training course, after which they attempted to contact people living with HIV through existing networks and self-help groups. Tuberculosis screening and testing were carried out in accordance with national guidelines. Local setting In Nepal, the prevalence of HIV infection is 0.3% in the general population but is much higher, at 6%, in people in Kathmandu who inject drugs. To date, the health system has not been able to implement systematic tuberculosis screening in people living with HIV. Relevant changes Between May 2014 and mid-September 2015, 30 volunteers screened 6642 people in 10 districts, 5430 (82%) of whom were living with HIV. Of the 6642, 6046 (91%) were tested for tuberculosis and 287 (4.3%) were diagnosed with the disease, 240 of whom were HIV-positive. Of those with tuberculosis, 270 (94%) initiated treatment. Lessons learnt Using peers to contact people living with HIV for tuberculosis screening resulted in a high participation rate and the identification of a considerable number of HIV-positive tuberculosis patients. Follow-up during treatment was difficult in this highly mobile group and needs more attention in future interventions. PMID:28250514

  12. Post-weaning living with parents during juvenile period alters locomotor activity, social and parental behaviors in mandarin voles.

    PubMed

    Wu, Ruiyong; Song, Zhenzhen; Tai, Fadao; Wang, Lu; Kong, Lingzhe; Wang, Jianli

    2013-09-01

    Neonatal parental care plays an important role in the development of offspring behavior, but little is known about the effect of post-weaning contact between offspring and parents on locomotory, social and parental behavior. Here, we explore this concept using socially monogamous mandarin voles (Microtus mandarinus). Voles were assigned to live with parents and siblings from the same litter until 45d (natural dispersal time in the field) or to live with siblings from the same litter after weaning at 21d (normally weaned time, the control). At 70d of age, behaviors were recorded in open field and social interaction tests, and parental care toward their own offspring was measured. Results show that voles that live with parents post-weaning engaged in less locomotory activity and rearing behavior in the open field test, less sniffing of novel individuals and displayed more parental care, compared to voles that did not continue to live with their parents. These findings demonstrate that parent-offspring interaction post-weaning alters locomotory activity, social behavior and parental behavior of offspring at adulthood.

  13. Live-cell Imaging of Pol II Promoter Activity to Monitor Gene expression with RNA IMAGEtag reporters

    SciTech Connect

    Shin, Ilchung; Ray, Judhajeet; Gupta, Vinayak; Ilgu, Muslum; Beasley, Jonathan; Bendickson, Lee; Mehanovic, Samir; Kraus, George A.; Nilsen-Hamilton, Marit

    2014-04-20

    We describe a ribonucleic acid (RNA) reporter system for live-cell imaging of gene expression to detect changes in polymerase II activity on individual promoters in individual cells. The reporters use strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags) that can be expressed from a promoter of choice. For imaging, the cells are incubated with their ligands that are separately conjugated with one of the FRET pair, Cy3 and Cy5. The IMAGEtags were expressed in yeast from the GAL1, ADH1 or ACT1 promoters. Transcription from all three promoters was imaged in live cells and transcriptional increases from the GAL1 promoter were observed with time after adding galactose. Expression of the IMAGEtags did not affect cell proliferation or endogenous gene expression. Advantages of this method are that no foreign proteins are produced in the cells that could be toxic or otherwise influence the cellular response as they accumulate, the IMAGEtags are short lived and oxygen is not required to generate their signals. The IMAGEtag RNA reporter system provides a means of tracking changes in transcriptional activity in live cells and in real time.

  14. Sociocultural perspectives on physical activity in the lives of older African American and American Indian women: a cross cultural activity participation study.

    PubMed

    Henderson, K A; Ainsworth, B E

    2000-01-01

    Illuminating the diversity and sociocultural specificity of women's experiences may be important if healthy lifestyles and quality of life are to be achieved. The incidence of cardiovascular disease linked to physical inactivity is high among African American and American Indian women. If more is understood about the experience of physical activity involvement, healthier living might be encouraged. Therefore, the purpose of this study was to explore the sociocultural meanings of physical activity for older (over the age of 40 years) African American and American Indian women who participated in the Cross Cultural Activity Participation Study (CAPS). Through qualitative in-depth interviews, we explored how sociocultural perspectives are related to perceptions about physical activity. Gender and other sociocultural factors influenced physical involvement on a continuum from negligible to significant. Both groups interviewed showed evidence that opportunities for physical activity in their free time did not always exist for them. For African American women, history and daily living issues were important factors limiting their involvement. Marginality limited American Indian women, but their cultural pride was often a source of physical activity. The juxtaposition of cultural and personal values emerged as a determinant of physical activity involvement among the women in this study. A further expansion of cultural and personal life situation perspectives is recommended to help understand the complex dimensions of physical activity as it relates to healthy living.

  15. From Data Acquisition to Data Fusion: A Comprehensive Review and a Roadmap for the Identification of Activities of Daily Living Using Mobile Devices.

    PubMed

    Pires, Ivan Miguel; Garcia, Nuno M; Pombo, Nuno; Flórez-Revuelta, Francisco

    2016-02-02

    This paper focuses on the research on the state of the art for sensor fusion techniques, applied to the sensors embedded in mobile devices, as a means to help identify the mobile device user's daily activities. Sensor data fusion techniques are used to consolidate the data collected from several sensors, increasing the reliability of the algorithms for the identification of the different activities. However, mobile devices have several constraints, e.g., low memory, low battery life and low processing power, and some data fusion techniques are not suited to this scenario. The main purpose of this paper is to present an overview of the state of the art to identify examples of sensor data fusion techniques that can be applied to the sensors available in mobile devices aiming to identify activities of daily living (ADLs).

  16. From Data Acquisition to Data Fusion: A Comprehensive Review and a Roadmap for the Identification of Activities of Daily Living Using Mobile Devices

    PubMed Central

    Pires, Ivan Miguel; Garcia, Nuno M.; Pombo, Nuno; Flórez-Revuelta, Francisco

    2016-01-01

    This paper focuses on the research on the state of the art for sensor fusion techniques, applied to the sensors embedded in mobile devices, as a means to help identify the mobile device user’s daily activities. Sensor data fusion techniques are used to consolidate the data collected from several sensors, increasing the reliability of the algorithms for the identification of the different activities. However, mobile devices have several constraints, e.g., low memory, low battery life and low processing power, and some data fusion techniques are not suited to this scenario. The main purpose of this paper is to present an overview of the state of the art to identify examples of sensor data fusion techniques that can be applied to the sensors available in mobile devices aiming to identify activities of daily living (ADLs). PMID:26848664

  17. Alkyne-tag Raman imaging of bio-active small molecules in live cells

    NASA Astrophysics Data System (ADS)

    Ando, Jun; Palonpon, Almar F.; Yamakoshi, Hiroyuki; Dodo, Kosuke; Kawata, Satoshi; Sodeoka, Mikiko; Fujita, Katsumasa

    2015-12-01

    Raman microscopy is useful for molecular imaging and analysis of biological specimens. Here, we used alkyne containing a carbon-carbon triple bond as a Raman tag for observing small molecules in live cells. Alkyne tags can maintain original properties of target molecules with providing high chemical specificity owing to its distinct peak in a Raman-silent window of biomolecules. For demonstrations, alkyne-tagged thymidine and coenzyme Q analogue in live cells were visualized with high-spatial resolution. We extended the application of alkyne-tag imaging to visualize cell organelles and specific lipid components in artificial monolayer membranes.

  18. Monitoring daily living activities of elderly people in a nursing home using an infrared motion-detection system.

    PubMed

    Suzuki, Ryoji; Otake, Sakuko; Izutsu, Takeshi; Yoshida, Masaki; Iwaya, Tsutomu

    2006-04-01

    We examined whether we could identify activity patterns of elderly people in a nursing home from sensor outputs of an infrared monitoring system. The subjects consisted of three elderly people. A single passive infrared sensor installed on the ceiling of each subject's usual dwelling room provided digital output whenever the subject moved. The subjects' actual daily activities were established from questionnaires with which patients documented their living patterns for each of 7 days. Activities were classed as sleeping, getting up/breakfast, indoor activities/going out, and dinner/going to bed. The mean +/- 2 standard deviations (SDs) of the sensor outputs on each day for each period of indoor activity was used to distinguish between normal and aberrant activities. Days on which sensor outputs exceeded the means +/- 2 SDs were regarded as atypical and were identified for each subject over a 28-day period. We were unable to determine the physical condition of the subjects on these atypical days. We were able to identify the pattern of daily indoor living activities and the duration of each class of activity using sensor outputs and a questionnaire. Days were assumed to be atypical when sensor outputs deviated from the normal pattern.

  19. Understanding Barriers and Facilitators to Healthy Eating and Active Living in Rural Communities

    PubMed Central

    Seguin, Rebecca; Nelson, Miriam; LaCroix, Andrea

    2014-01-01

    Objective. Studies demonstrate that people's food and physical activity (PA) environments influence behavior, yet research examining this in rural communities is limited. Methods. Focus groups of 8–15 women were conducted in rural communities in seven US states. Questions were designed to identify factors within residents' food and PA environments they felt helped or hindered them from eating healthfully and being physically active. Results. Participants were aged 30–84 years; mean (SD) = 61 (14) (N = 95). On average, communities had fewer than 5,000 residents. Limited time, social norms, and distances from or lack of exercise facilities were common PA barriers. Facilitators for PA included social support, dog walking, and availability of affordable facilities. Healthy eating barriers included the perception that healthy foods were too expensive; calorically dense large portion sizes served at family meals; and frequency of eating foods away from home, which were perceived as generally unhealthy. Healthy eating supports included culture/value around local food gathering (e.g., hunting and gardening) and preservation (e.g., canning and smoking). Friends and family were frequently identified as key influencers of eating and PA behavior. Conclusions. Targeting both social and built environment factors, particularly those unique to rural locales, may enhance support for healthy eating and PA behavior change interventions. PMID:25574386

  20. Telling Moments and Everyday Experience: Multiple Methods Research on Couple Relationships and Personal Lives

    PubMed Central

    Gabb, Jacqui; Fink, Janet

    2015-01-01

    Everyday moments and ordinary gestures create the texture of long-term couple relationships. In this article we demonstrate how, by refining our research tools and conceptual imagination, we can better understand these vibrant and visceral relationships. The ‘moments approach’ that we propose provides a lens through which to focus in on couples’ everyday experiences, to gain insight on processes, meanings and cross-cutting analytical themes whilst ensuring that feelings and emotionality remain firmly attached. Calling attention to everyday relationship practices, we draw on empirical research to illustrate and advance our conceptual and methodological argument. The Enduring Love? study included an online survey (n = 5445) and multi-sensory qualitative research with couples (n = 50) to interrogate how they experience, understand and sustain their long-term relationships. PMID:26456983

  1. Intra-individual Neurocognitive Variability Confers Risk of Dependence in Activities of Daily Living among HIV-Seropositive Individuals without HIV-Associated Neurocognitive Disorders

    PubMed Central

    Morgan, Erin E.; Woods, Steven Paul; Grant, Igor

    2012-01-01

    Although HIV-associated neurocognitive disorders (HAND) are the strong predictors of everyday functioning difficulties, approximately half of all functionally impaired individuals are labeled “neurocognitively normal” according to the standard neuropsychological measures, suggesting that novel predictors of functional problems in this prevalent subgroup are needed. The present study hypothesized that increased neurocognitive intra-individual variability as indexed by dispersion would be associated with poor daily functioning among 82 persons with HIV infection who did not meet research criteria for HAND. An intra-individual standard deviation was calculated across the demographically adjusted T-scores of 13 standard neuropsychological tests to represent dispersion, and functional outcomes included self-reported declines in basic and instrumental activities of daily functioning (basic activity of daily living [BADL] and instrumental activity of daily living [IADL], respectively) and medication management. Dispersion was a significant predictor of medication adherence and dependence in both BADL and IADL, even when other known predictors of functional status (i.e., age, affective distress, and indices of disease severity) were included in the models. As a significant and unique predictor of a performance on the range of daily functioning activities, neurocognitive dispersion may be indicative of deficient cognitive control expressed as inefficient regulation of neurocognitive resources in the context of competing functional demands. As such, dispersion may have clinical utility in detecting risk for functional problems among HIV-infected individuals without HAND. PMID:22337933

  2. Intra-individual neurocognitive variability confers risk of dependence in activities of daily living among HIV-seropositive individuals without HIV-associated neurocognitive disorders.

    PubMed

    Morgan, Erin E; Woods, Steven Paul; Grant, Igor

    2012-05-01

    Although HIV-associated neurocognitive disorders (HAND) are the strong predictors of everyday functioning difficulties, approximately half of all functionally impaired individuals are labeled "neurocognitively normal" according to the standard neuropsychological measures, suggesting that novel predictors of functional problems in this prevalent subgroup are needed. The present study hypothesized that increased neurocognitive intra-individual variability as indexed by dispersion would be associated with poor daily functioning among 82 persons with HIV infection who did not meet research criteria for HAND. An intra-individual standard deviation was calculated across the demographically adjusted T-scores of 13 standard neuropsychological tests to represent dispersion, and functional outcomes included self-reported declines in basic and instrumental activities of daily functioning (basic activity of daily living [BADL] and instrumental activity of daily living [IADL], respectively) and medication management. Dispersion was a significant predictor of medication adherence and dependence in both BADL and IADL, even when other known predictors of functional status (i.e., age, affective distress, and indices of disease severity) were included in the models. As a significant and unique predictor of a performance on the range of daily functioning activities, neurocognitive dispersion may be indicative of deficient cognitive control expressed as inefficient regulation of neurocognitive resources in the context of competing functional demands. As such, dispersion may have clinical utility in detecting risk for functional problems among HIV-infected individuals without HAND.

  3. Commercial Style Market Research for Navy Activities

    DTIC Science & Technology

    1993-12-01

    market research and analysis and indicate their impact on the various elements of the plan. If the acquisition or part...was not or will not be conducted.. .Once the Government’s needs have been func- tionally described, market research and analysis shall be conducted to...Systems Management College, 1993, pp. 409-420. 44. Lee, Christopher, Office Director, Office of Market Research and Analysis , Defense Fuels Supply

  4. The United States Culture Collection Network (USCCN): Enhancing Microbial Genomics Research through Living Microbe Culture Collections

    PubMed Central

    Boundy-Mills, Kyria; Hess, Matthias; Bennett, A. Rick; Ryan, Matthew; Kang, Seogchan; Nobles, David; Eisen, Jonathan A.; Inderbitzin, Patrik; Sitepu, Irnayuli R.; Torok, Tamas; Brown, Daniel R.; Cho, Juliana; Wertz, John E.; Mukherjee, Supratim; Cady, Sherry L.

    2015-01-01

    The mission of the United States Culture Collection Network (USCCN; http://usccn.org) is “to facilitate the safe and responsible utilization of microbial resources for research, education, industry, medicine, and agriculture for the betterment of human kind.” Microbial culture collections are a key component of life science research, biotechnology, and emerging global biobased economies. Representatives and users of several microbial culture collections from the United States and Europe gathered at the University of California, Davis, to discuss how collections of microorganisms can better serve users and stakeholders and to showcase existing resources available in public culture collections. PMID:26092453

  5. The United States Culture Collection Network (USCCN): Enhancing Microbial Genomics Research through Living Microbe Culture Collections

    SciTech Connect

    Boundy-Mills, K.; Hess, Matthias; Bennett, A. R.; Ryan, Matthew; Kang, Seogchan; Nobles, David; Eisen, Jonathan A.; Inderbitzin, Patrik; Sitepu, Irnayuli R.; Torok, Tamas; Brown, Daniel R; Cho, Juliana; Wertz, John E.; Mukherjee, Supratim; Cady, Sherry L.; McCluskey, Kevin

    2015-09-01

    The mission of the United States Culture Collection Network (USCCN; http://usccn.org) is "to facilitate the safe and responsible utilization of microbial resources for research, education, industry, medicine, and agriculture for the betterment of human kind." Microbial culture collections are a key component of life science research, biotechnology, and emerging global biobased economies. Representatives and users of several microbial culture collections from the United States and Europe gathered at the University of California, Davis, to discuss how collections of microorganisms can better serve users and stakeholders and to showcase existing resources available in public culture collections.

  6. The United States Culture Collection Network (USCCN): Enhancing Microbial Genomics Research through Living Microbe Culture Collections.

    PubMed

    Boundy-Mills, Kyria; Hess, Matthias; Bennett, A Rick; Ryan, Matthew; Kang, Seogchan; Nobles, David; Eisen, Jonathan A; Inderbitzin, Patrik; Sitepu, Irnayuli R; Torok, Tamas; Brown, Daniel R; Cho, Juliana; Wertz, John E; Mukherjee, Supratim; Cady, Sherry L; McCluskey, Kevin

    2015-09-01

    The mission of the United States Culture Collection Network (USCCN; http://usccn.org) is "to facilitate the safe and responsible utilization of microbial resources for research, education, industry, medicine, and agriculture for the betterment of human kind." Microbial culture collections are a key component of life science research, biotechnology, and emerging global biobased economies. Representatives and users of several microbial culture collections from the United States and Europe gathered at the University of California, Davis, to discuss how collections of microorganisms can better serve users and stakeholders and to showcase existing resources available in public culture collections.

  7. Effects of Stroke on Ipsilesional End-Effector Kinematics in a Multi-Step Activity of Daily Living

    PubMed Central

    Gulde, Philipp; Hughes, Charmayne Mary Lee; Hermsdörfer, Joachim

    2017-01-01

    Background: Stroke frequently impairs activities of daily living (ADL) and deteriorates the function of the contra- as well as the ipsilesional limbs. In order to analyze alterations of higher motor control unaffected by paresis or sensory loss, the kinematics of ipsilesional upper limb movements in patients with stroke has previously been analyzed during prehensile movements and simple tool use actions. By contrast, motion recording of multi-step ADL is rare and patient-control comparisons for movement kinematics are largely lacking. Especially in clinical research, objective quantification of complex externally valid tasks can improve the assessment of neurological impairments. Methods: In this preliminary study we employed three-dimensional motion recording and applied kinematic analysis in a multi-step ADL (tea-making). The trials were examined with respect to errors and sub-action structure, durations, path lengths (PLs), peak velocities, relative activity (RA) and smoothness. In order to check for specific burdens the sub-actions of the task were extracted and compared. To examine the feasibility of the approach, we determined the behavioral and kinematic metrics of the (ipsilesional) unimanual performance of seven chronic stroke patients (64a ± 11a, 3 with right/4 with left brain damage (LBD), 2 with signs of apraxia, variable severity of paresis) and compared the results with data of 14 neurologically healthy age-matched control participants (70a ± 7a). Results: T-tests revealed that while the quantity and structure of sub-actions of the task were similar. The analysis of end-effector kinematics was able to detect clear group differences in the associated parameters. Specifically, trial duration (TD) was increased (Cohen’s d = 1.77); the RA (Cohen’s d = 1.72) and the parameters of peak velocities (Cohen’s d = 1.49/1.97) were decreased in the patient group. Analysis of the task’s sub-actions repeated measures analysis of variance (rmANOVA) revealed

  8. Biology Research Activities: Teacher's Edition (with Answers).

    ERIC Educational Resources Information Center

    Newman, Barbara

    This book is part of the series "Explorations in Science" which contains enrichment activities for the general science curriculum. Each book in the series contains innovative and traditional projects for both the bright and average, the self-motivated, and those who find activity motivating. Each activity is self-contained and provides everything…

  9. Fitness and Physical Activity. Research Brief

    ERIC Educational Resources Information Center

    Walker, Karen

    2005-01-01

    What can be done to support fitness and physical activity? Schools can guide students in developing life-long habits of participating in physical activities. According to the National Association for Sports and Physical Education, the concepts of physical fitness activities and physical education are used synonymously, however, they are not the…

  10. Relationship of Cognitive Functions with Daily Living Activities, Depression, Anxiety and Clinical Variables in Hospitalized Elderly Patients

    PubMed Central

    DEMİR AKÇA, Ayşe Semra; SARAÇLI, Özge; EMRE, Ufuk; ATASOY, Nuray; GÜDÜL, Serdar; ÖZEN BARUT, Banu; ŞENORMANCI, Ömer; BÜYÜKUYSAL, M. Çağatay; ATİK, Levent; ATASOY, H. Tuğrul

    2014-01-01

    Introduction Cognitive impairment in elderly patients, which may be a sign of dementia, depression, anxiety or medical diseases, has been determined as a risk factor for functional loss. In this study, we aimed to investigate the frequency of cognitive impairment and to investigate the relationship of cognitive status with sociodemographic variables, daily living activities, anxiety and depression in elderly inpatients. Method The sample of this cross-sectional and descriptive study consists of 243 patients aged 65 years and older who were hospitalized in Bülent Ecevit University Hospital. A sociodemographic questionnaire,, the Mini-Mental State Examination (MMSE), Activities of Daily Living Scale, Lawton-Brody Instrumental Daily Activities Scale, Geriatric Depression Scale (GDS) and the Beck Anxiety Inventory were used for data collection. Results One hundred and six (43.6%) patients were female and 137 (56.4%) were male. The patients were divided into two groups according to the Mini-Mental State Examination (MMSE) 23/24 cut-off score. The cognitive decline was statistically significantly more frequent in patients who were older, female, less educated, low socioeconomic status, and living in rural areas. There were more problems in the basic and instrumental activities of daily living and nutrition in patients with cognitive decline. Anxiety and depression scores were higher in this group. In our study, although the frequency of cognitive decline and depression according to GDS were 56% and 48%, respectively; we found that only 10.5% of patients applied to the psychiatrist, and 9.3% of patients received psychiatric treatment. Conclusion Cognitive decline may cause deterioration in the daily living activities, nutrition and capacity for independent functioning. Older age, female, low education, low socioeconomic status and living in rural area are important risk factors for cognitive impairment. Cognitive decline in older age may be associated with depression and

  11. Functional Status Assessment of COPD Based on Ability to Perform Daily Living Activities: A Systematic Review of Paper and Pencil Instruments

    PubMed Central

    Monjazebi, Fateme; Dalvandi, Asghar; Ebadi, Abbas; Khankeh, Hamid Reza; Rahgozar, Mahdi; Richter, Jörg

    2016-01-01

    Context: Activity of daily living (ADL) is an important predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Increasing ADL is important in patients with COPD and assessment of ADL is one of the best ways to evaluate the status of COPD patients. Objectives: The objective of this systematic review was to provide an overview of the psychometric properties of paper and pencil instruments measuring ADL in patients with COPD. Data Sources: English papers published from 1980 to 2014 regarding ADL in patients with COPD were searched in Web of Science, MEDLINE, Google Scholar, Cochrane, PubMed, ProQuest, and CINAHL databases using the following keywords: “COPD”, “ADL”, “activities of daily living”, “daily activities”, “instrument”, “questionnaire”, “paper-and-pencil instruments”, and “measure”. Following the Internet search, manual search was also done to find article references. Study Selection: A total of 186 articles were found. Of those, 31 met the inclusion criteria. Full texts of articles meeting the inclusion criteria were studied. Consensus-based standards for the selection of health measurement instruments”(COSMIN) were used to assess the quality of the studies. Data Extraction: Data extraction form based on research aims developed by researchers and psychometric experts, with 17 questions was used. Results: In these articles, 14 pen and paper instruments were identified for examining ADL in patients with COPD; of which, 4 dealt directly with ADL while 9 assessed other criteria i.e. dyspnea as ADL indicator. The majority of instruments only dealt with two main dimensions of ADL: Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL), and did not consider Advanced Activities of Daily Living (AADL), which is influenced by cultural and motivational factors. Conclusion: Despite several ADL instruments identified, complete psychometric processes have only been done in

  12. Activities of Daily Living Curriculum for Handicapped Adults. Materials Development Center Reprint #20.

    ERIC Educational Resources Information Center

    Wisconsin Univ. - Stout, Menomonie. Dept. of Rehabilitation and Manpower Services. Materials Development Center.

    Designed for use in group and shelter homes, this curriculum is intended to impart the necessary skills for independent living. It should also better prepare mentally and physically handicapped individuals with the training required to handle the responsibilities accompanying competitive employment. These fourteen courses are included: money…

  13. Making It Better: Activities for Children Living in a Stressful World, Second Edition

    ERIC Educational Resources Information Center

    Oehlberg, Barbara

    2014-01-01

    Children living with uncertainty and insecurity often have difficulty focusing on learning. They might demonstrate disrespectful or defiant behaviors, act out, or act with aggression. As an educator, you may provide the only stability in their otherwise turbulent world. "Making It Better" explains trauma-­informed education, an approach…

  14. Ecological Momentary Assessment: A Research Method for Studying the Daily Lives of Teachers

    ERIC Educational Resources Information Center

    Carson, Russell L.; Weiss, Howard M.; Templin, Thomas J.

    2010-01-01

    The purpose of this paper is to introduce ecological momentary assessment (EMA) as an effective approach for capturing teachers' emotional states and behaviours over time. Although the implementation of EMA has a rich and successful history among social science researchers in general, traditional retrospective, self-report methods for collecting…

  15. Harvard-MIT research program in short-lived radiopharmaceuticals. Technical progress report, 1991

    SciTech Connect

    Adelstein, S.J.

    1991-12-31

    This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)

  16. Seeking New Ways of Living Community in the Classroom and the World: An Action Research Study

    ERIC Educational Resources Information Center

    Morris, Anne

    2012-01-01

    Action research is a method of examining one's own practice through reflection and critical self-study. In this paper, the author considers her experience teaching a two-day lesson on connections and relationships in William Forsythe's dance "One Flat Thing, reproduced" (2000) and the accompanying website, Synchronous Objects. The author reviews…

  17. Youth Who "Age Out" of Foster Care: Troubled Lives, Troubling Prospects. Child Trends Research Brief.

    ERIC Educational Resources Information Center

    Wertheimer, Richard

    Noting that the population of foster children who "age out" of the foster care system may be even more at risk than other foster children, this research brief summarizes a longer report examining trends in foster care in the United States, the number and needs of those aging out of the system, and public policy implications. The brief indicates…

  18. With Children in Their Lived Place: Children's Action as Research Data

    ERIC Educational Resources Information Center

    Raittila, Raija

    2012-01-01

    This article discusses theory and methods of researching the everyday experiences of children in the city environment combined with the question of giving a voice to children. The article is organised into three parts. Part one provides a conceptual background, theorising the relational as well as intergenerational character of the concept of…

  19. Optimizing Social Network Support to Families Living With Parental Cancer: Research Protocol for the Cancer-PEPSONE Study

    PubMed Central

    2015-01-01

    first results are anticipated to be finished by November 2015. Conclusions To our knowledge, this will be the first RCT study to optimize social network support through a psycho-educational program for families living with parental cancer and their network members, as well as provide an evidence basis for social network support. The results may provide important knowledge that is useful for clinical practice and further research. The trial is reported according to the CONSORT checklist. ClinicalTrial International Standard Randomized Controlled Trial Number (ISRCTN): 15982171; http://www.controlled-trials.com/ISRCTN15982171/15982171 (Archived by WebCite at http://www.webcitation.org/6cg9zunS0) PMID:26733339

  20. Ecological Validity of Virtual Reality Daily Living Activities Screening for Early Dementia: Longitudinal Study

    PubMed Central

    Schlee, Winfried; Tsolaki, Magda; Müri, René; Mosimann, Urs; Nef, Tobias

    2013-01-01

    , and chair stands separately and while performing VR-DOTs in order to correlate performance in these measures with VR-DOTs because performance while navigating a virtual environment is a valid and reliable indicator of cognitive decline in elderly persons. Results The mild AD group was more impaired than the amnestic MCI group, and both were more impaired than healthy controls. The novel VR-DOT functional index correlated strongly with standard cognitive and functional measurements, such as mini-mental state examination (MMSE; rho=0.26, P=.01) and Bristol Activities of Daily Living (ADL) scale scores (rho=0.32, P=.001). Conclusions Functional impairment is a defining characteristic of predementia and is partly dependent on the degree of cognitive impairment. The novel virtual reality measures of functional ability seem more sensitive to functional impairment than qualitative measures in predementia, thus accurately differentiating from healthy controls. We conclude that VR-DOT is an effective tool for discriminating predementia and mild AD from controls by detecting differences in terms of errors, omissions, and perseverations while measuring ADL functional ability. PMID:25658491

  1. Effects of kinesiology taping on the upper-extremity function and activities of daily living in patients with hemiplegia

    PubMed Central

    Kim, Eung-beom; Kim, Young-dong

    2015-01-01

    [Purpose] This study determined the effects of kinesiology taping on the upper-extremity function and activities of daily living of patients with hemiplegia. [Subjects] The experimental group and control group comprised 15 hemiplegia patients each. [Methods] This study was performed from June 4 to December 22, 2012, involving 30 hemiplegia patients. The experimental and controls groups performed task practices for 30 minutes, 3 times per week for 28 weeks with and without taping, respectively. [Results] After treatment, there were significant differences in every outcome measures within each group except for the Brunnstrom recovery stage of the hand. However, there was a significant difference in functional independence movements between the groups. [Conclusion] Task practice has the same effectiveness regardless of the taping of the upper extremities. Nevertheless, taping is helpful for improving both the functions and activities of daily living in patients with hemiplegia. PMID:26157239

  2. The global deterioration scale: relationships to neuropsychological performance and activities of daily living in patients with vascular dementia.

    PubMed

    Paul, Robert H; Cohen, Ronald A; Moser, David J; Zawacki, Tricia; Ott, Brian R; Gordon, Norman; Stone, William

    2002-01-01

    In the present study, we examined the relationships between ratings on the Global Deterioration Scale (GDS) and activities of daily living and cognitive function in 39 individuals with vascular dementia (VaD). The results of the study revealed significant correlations between GDS rating and performance on cognitive tests, including memory and overall cognitive ability. In addition, the GDS was significantly related to ratings of instrumental activities of daily living. Comparisons between patients with VaD with GDS scores between 4 and 6 (n = 21) and patients with scores between 2 and 3 (n = 18) revealed greater cognitive and functional deficits in the group with higher GDS scores. Further, the GDS score accurately classified 87% of the patients with VaD. These findings provide support for the validity of the GDS in general staging of dementia severity of VaD.

  3. Nursing research--taking an active interest.

    PubMed

    Cleverly, D

    1998-05-01

    This paper discusses the issues raised by the still unfolding transformation of nurse education attitudes to research, from the traditional stance--that it was something that other people do--to the realization that quality research is central to the development of the profession and its competitive survival into the 21st century. In particular, the problems and challenges presented by the Higher Education Funding Council for England research assessment exercise, and the policy of the funding council, are examined. Research in schools of nursing is reviewed under the headings of funding, contracts, support, discipline, publication and staff recruitment and retention, to attempt to identify those approaches most likely to yield a research output of an acceptable volume and quality.

  4. Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci.

    PubMed

    Horgan, Marianne; O'Flynn, Gary; Garry, Jennifer; Cooney, Jakki; Coffey, Aidan; Fitzgerald, Gerald F; Ross, R Paul; McAuliffe, Olivia

    2009-02-01

    A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

  5. Performance-based assessment of activities of daily living (ADL) ability among women with chronic widespread pain.

    PubMed

    Waehrens, Eva Ejlersen; Amris, Kirstine; Fisher, Anne G

    2010-09-01

    Functional ability, including the ability to perform activities of daily living (ADL), is considered a core outcome domain in chronic pain clinical trials and is usually assessed through generic or disease-specific self-report questionnaires. Research, however, indicates that self-report and performance-based assessment of ADL offer distinct but complementary information about ability. The present study, therefore, investigated the applicability of a performance-based measure of ADL ability, the Assessment of Motor and Process Skills (AMPS), among 50 women with chronic widespread pain. The investigated psychometric properties of the AMPS included discrimination between a sample of healthy women and those with chronic widespread pain, as well as stability when no intervention was provided and sensitivity to change following intervention. Data were obtained based on a repeated measures design performing AMPS evaluations twice pre- and twice post-rehabilitation. Results indicated that the ADL motor ability measures of the participants were significantly lower than those of healthy women of same age, the ADL motor and ADL process ability measures remained stable when no intervention was provided and the ADL motor ability measures were sensitive to change following a 2-week interdisciplinary rehabilitation program. A weak correlation (r(s)=-0.35) was found between self-reported ADL ability as measured by the physical function subscale of the Functional Impact Questionnaire (FIQ) and performance-based ADL motor measures, and no correlation (r(s)=-0.02) was found between FIQ ADL measures and ADL process ability, supporting the need for both performance-based and self-reported assessment of ADL.

  6. Unhealthy habits and practice of physical activity in Spanish college students: the role of gender, academic profile and living situation.

    PubMed

    Molina, Antonio J; Varela, Verónica; Fernández, Tania; Martín, Vicente; Ayán, Carlos; Cancela, José M

    2012-01-01

    The aim of this study is to identify personal factors associated with drugs use and the practice of physical activity in a college student population in northwest Spain. A cross-sectional survey was conducted between January and April 2010 using a self-administered questionnaire including questions concerning gender, age, course and year of study, living arrangements and work. Participants were asked also about current tobacco use, alcohol drinking and heavy episodic drinking, illegal drugs use, and frequency of physical activity. Prevalences were calculated and bivariate and multivariate logistic regression analyses were conducted to calculate separate models for the different habits making adjustments for the demographic variables. Most of students consumed alcohol (78.3%), with 31.7% consuming tobacco and 34% having used illegal drugs at some point. The prevalence of sufficient physical activity was about 22.7% and it was clearly lower in women and in courses no linked with sports. Women have been lesser consumers of illegal drugs and alcohol. However, heavy episodic drinking is clearly associated with women. Living with friends was noticed as a risk factor, both for tobacco use and the consumption of alcohol and illegal drugs, when compared with living at home. Courses of study connected with sport, health and education showed a lower prevalence of drug uses than the other courses analysed. Since distribution of drug use and insufficient physical activity depending on gender, living arrangement and the course of study, it would be appropriate to design more efficient interventions of health promotion take these differences into account.

  7. Living Together in Commercial Harmony: Research as a Catalyst for Cooperative "Town-Gown" Relations. Research Report 17-89.

    ERIC Educational Resources Information Center

    Balenger, Victoria J.; And Others

    In some communities, commercial activity by the local university is perceived as a threat to the reciprocity of the "town-gown" exchange relationship. This study was designed to provide an information base from which negotiations in this area could proceed. Students (N=200) and faculty/staff (N=100) at the University of Maryland, College…

  8. Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection

    PubMed Central

    Fazeli, Pariya L.; Doyle, Katie L.; Scott, J. Cobb; Iudicello, Jennifer E.; Casaletto, Kaitlin B.; Weber, Erica; Moore, David J.; Morgan, Erin E.; Grant, Igor; Woods, Steven Paul; Hampton Atkinson, J.; Ellis, Ronald J.; Allen McCutchan, J.; Marcotte, Thomas D.; Marquie-Beck, Jennifer; Sherman, Melanie; Ellis, Ronald J.; Allen McCutchan, J.; Letendre, Scott; Capparelli, Edmund; Schrier, Rachel; Rosario, Debra; LeBlanc, Shannon; Heaton, Robert K.; Woods, Steven Paul; Cherner, Mariana; Moore, David J.; Morgan, Erin E.; Dawson, Matthew; Jernigan, Terry; Fennema-Notestine, Christine; Archibald, Sarah L.; Hesselink, John; Annese, Jacopo; Taylor, Michael J.; Masliah, Eliezer; Achim, Cristian; Everall, Ian; Richman, Douglas; Smith, David M.; Allen McCutchan, J.; Achim, Cristian; Lipton, Stuart; Hampton Atkinson, J.; Gamst, Anthony C.; Cushman, Clint; Abramson, Ian; Vaida, Florin; Deutsch, Reena; Umlauf, Anya

    2014-01-01

    Aging and HIV are both risk factors for memory deficits and declines in real-world functioning. However, we know little about the profile of memory deficits driving instrumental activities of daily living (IADL) declines across the lifespan in HIV. This study examined 145 younger (<50 years) and 119 older (≥50 years) adults with HIV who completed the California Verbal Learning Test-Second Edition (CVLT-II), the Wechsler Memory Scale-Third Edition Logical Memory subtest (WMS-III LM), and a modified Lawton and Brody ADL questionnaire. No memory predictors of IADL dependence emerged in the younger cohort. In the older group, IADL dependence was uniquely associated with worse performance on all primary CVLT-II variables, as well as elevated recency effects. Poorer immediate and delayed recall of the WMS-III LM was also associated with IADL dependence, although recognition was intact. Findings suggest older HIV-infected adults with shallow encoding and forgetting are at risk for IADL dependence. PMID:24695591

  9. Shallow encoding and forgetting are associated with dependence in instrumental activities of daily living among older adults living with HIV infection.

    PubMed

    Fazeli, Pariya L; Doyle, Katie L; Scott, J Cobb; Iudicello, Jennifer E; Casaletto, Kaitlin B; Weber, Erica; Moore, David J; Morgan, Erin E; Grant, Igor; Woods, Steven Paul

    2014-05-01

    Aging and HIV are both risk factors for memory deficits and declines in real-world functioning. However, we know little about the profile of memory deficits driving instrumental activities of daily living (IADL) declines across the lifespan in HIV. This study examined 145 younger (<50 years) and 119 older (≥50 years) adults with HIV who completed the California Verbal Learning Test-Second Edition (CVLT-II), the Wechsler Memory Scale-Third Edition Logical Memory subtest (WMS-III LM), and a modified Lawton and Brody ADL questionnaire. No memory predictors of IADL dependence emerged in the younger cohort. In the older group, IADL dependence was uniquely associated with worse performance on all primary CVLT-II variables, as well as elevated recency effects. Poorer immediate and delayed recall of the WMS-III LM was also associated with IADL dependence, although recognition was intact. Findings suggest older HIV-infected adults with shallow encoding and forgetting are at risk for IADL dependence.

  10. Research to Improve Emotional Health and Quality of Life Among Service Members with Disabilities (RESTORE LIVES)

    DTIC Science & Technology

    2013-10-01

    Lester D. Post-traumatic stress disorder and suicide risk: a systematic review. Archives of Suicide Research 2010;14:1-23. 8. Oquendo MA, Friend JM...Statement of Work and milestones. 15. SUBJECT TERMS Post-traumatic stress disorder, psychotherapy, stress , mild traumatic brain injury, women veterans...with varying levels of stress -induced comorbidities. It is anticipated that the proposed day of recognition and services for female veterans within

  11. Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering microscopy (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Hu, Fanghao; Chen, Zhixing; Zhang, Luyuan; Shen, Yihui; Wei, Lu; Min, Wei

    2016-03-01

    Glucose is consumed as an energy source by virtually all living organisms, from bacteria to humans. Its uptake activity closely reflects the cellular metabolic status in various pathophysiological transformations, such as diabetes and cancer. Extensive efforts such as positron emission tomography, magnetic resonance imaging and fluorescence microscopy have been made to specifically image glucose uptake activity but all with technical limitations. Here, we report a new platform to visualize glucose uptake activity in live cells and tissues with subcellular resolution and minimal perturbation. A novel glucose analogue with a small alkyne tag (carbon-carbon triple bond) is developed to mimic natural glucose for cellular uptake, which can be imaged with high sensitivity and specificity by targeting the strong and characteristic alkyne vibration on stimulated Raman scattering (SRS) microscope to generate a quantitative three dimensional concentration map. Cancer cells with differing metabolic characteristics can be distinguished. Heterogeneous uptake patterns are observed in tumor xenograft tissues, neuronal culture and mouse brain tissues with clear cell-cell variations. Therefore, by offering the distinct advantage of optical resolution but without the undesirable influence of bulky fluorophores, our method of coupling SRS with alkyne labeled glucose will be an attractive tool to study energy demands of living systems at the single cell level.

  12. Seasonal Variation in Population Density and Heterotrophic Activity of Attached and Free-Living Bacteria in Coastal Waters

    PubMed Central

    Iriberri, Juan; Unanue, Marian; Barcina, Isabel; Egea, Luis

    1987-01-01

    The abundance and heterotrophic activity of attached and free-living bacteria were examined seasonally in coastal water. Heterotrophic activity was determined by the uptake of [14C]glucose. The density of attached bacteria was always minor, not showing a seasonal variation, whereas the free-living bacteria were more numerous and showed a marked seasonal variation, their density being higher under warmer conditions. The contribution of the attached bacteria to the total assimilation of [14C]glucose (from 10 to 38%) was lower than that of the free-living bacteria, neither of them showing a seasonal variation. On a cellular basis, attached bacteria were more active, since they assimilated more [14C]glucose and showed, under warmer conditions, a higher cellular volume (0.102 versus 0.047 μm3). We consider that the factors responsible for these observations were the amount and quality of the particulate material, the different availability of organic matter for the two types of bacteria, and in a fundamental way, the variation in water temperature. PMID:16347451

  13. A l'ecole maternelle francaise: Vivre ensemble et pratiquer des activities d'art plastique. [In a French Nursery School: Living and Creating Together].

    ERIC Educational Resources Information Center

    International Journal of Early Childhood, 1999

    1999-01-01

    Discusses the role of collective creative activity in developing preschool children's multicultural understanding and ability to live together. Notes artistic and language-based activities used in French preschools to teach these concepts and develop critical and responsible behavior. (JPB)

  14. Research in subliminal psychodynamic activation: note on Masling (1998).

    PubMed

    Fudin, R

    1999-04-01

    Masling (1998) questioned Malik, Apel, Nelham, Rutkowski, and Ladd's 1997 suggestion that subliminal psychodynamic activation research with MOMMY AND I ARE ONE should be restricted. Problems in Masling's paper and the scope of research with MOMMY AND I ARE ONE are discussed. His position that such research should not be restricted is supported on the condition that subliminal psychodynamic activation research with MOMMY AND I ARE ONE (and other messages) use Fudin's 1986 procedure that could clarify the interpretation of successful experimental outcomes.

  15. Near-Infrared Light Activation of Proteins Inside Living Cells Enabled by Carbon Nanotube-Mediated Intracellular Delivery.

    PubMed

    Li, He; Fan, Xinqi; Chen, Xing

    2016-02-01

    Light-responsive proteins have been delivered into the cells for controlling intracellular events with high spatial and temporal resolution. However, the choice of wavelength is limited to the UV and visible range; activation of proteins inside the cells using near-infrared (NIR) light, which has better tissue penetration and biocompatibility, remains elusive. Here, we report the development of a single-walled carbon nanotube (SWCNT)-based bifunctional system that enables protein intracellular delivery, followed by NIR activation of the delivered proteins inside the cells. Proteins of interest are conjugated onto SWCNTs via a streptavidin-desthiobiotin (SA-DTB) linkage, where the protein activity is blocked. SWCNTs serve as both a nanocarrier for carrying proteins into the cells and subsequently a NIR sensitizer to photothermally cleave the linkage and release the proteins. The released proteins become active and exert their functions inside the cells. We demonstrated this strategy by intracellular delivery and NIR-triggered nuclear translocation of enhanced green fluorescent protein, and by intracellular delivery and NIR-activation of a therapeutic protein, saporin, in living cells. Furthermore, we showed that proteins conjugated onto SWCNTs via the SA-DTB linkage could be delivered to the tumors, and optically released and activated by using NIR light in living mice.

  16. Using Adolescent Literature To Develop Student Pride in Rural Living.

    ERIC Educational Resources Information Center

    Spiegel, Lisa A.

    1997-01-01

    Learning activities that promote student pride in rural living include examining the misconceptions and prejudices associated with rural living, exploring the variables of a rural lifestyle, student research of their town's history, and reading books that positively portray rural living. Includes a bibliography of 69 adolescent books with rural…

  17. Racemization and the origin of optically active organic compounds in living organisms

    NASA Technical Reports Server (NTRS)

    Bada, J. L.; Miller, S. L.

    1987-01-01

    The organic compounds synthesized in prebiotic experiments are racemic mixtures. A number of proposals have been offered to explain how asymmetric organic compounds formed on the Earth before life arose, with the influence of chiral weak nuclear interactions being the most frequent proposal. This and other proposed asymmetric syntheses give only sight enantiomeric excess and any slight excess will be degraded by racemization. This applies particularly to amino acids where half-lives of 10(5)-10(6) years are to be expected at temperatures characteristic of the Earth's surface. Since the generation of chiral molecules could not have been a significant process under geological conditions, the origins of this asymmetry must have occurred at the time of the origin of life or shortly thereafter. It is possible that the compounds in the first living organisms were prochiral rather than chiral; this is unlikely for amino acids, but it is possible for the monomers of RNA-like molecules.

  18. Observations of a live Glaucous-winged Gull chick in an active Bald Eagle nest

    USGS Publications Warehouse

    Anthony, R.G.; Faris, J.T.

    2003-01-01

    We report an apparent nonlethal predation attempt on and subsequent adoption of a Glaucous-winged Gull (Larus glaucescens) chick by a pair of Bald Eagles (Haliaeetus leucocephalus) in the Aleutian Archipelago, Alaska. To the best of our knowledge, this is the first report of a live Glaucous-winged Gull chick in a Bald Eagle nest. We describe our observations of this occurrence and offer explanations on how it may have occurred.

  19. Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat

    PubMed Central

    Dziegelewska, Maja; Holtze, Susanne; Vole, Christiane; Wachter, Ulrich; Menzel, Uwe; Morhart, Michaela; Groth, Marco; Szafranski, Karol; Sahm, Arne; Sponholz, Christoph; Dammann, Philip; Huse, Klaus; Hildebrandt, Thomas; Platzer, Matthias

    2016-01-01

    Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration. PMID:26803480

  20. Drosophotoxicology: An Emerging Research Area for Assessing Nanoparticles Interaction with Living Organisms

    PubMed Central

    Chifiriuc, Mariana Carmen; Ratiu, Attila Cristian; Popa, Marcela; Ecovoiu, Alexandru Al.

    2016-01-01

    The rapid development of nanotechnology allowed the fabrication of a wide range of different nanomaterials, raising many questions about their safety and potential risks for the human health and environment. Most of the current nanotoxicology research is not standardized, hampering any comparison or reproducibility of the obtained results. Drosophotoxicology encompasses the plethora of methodological approaches addressing the use of Drosophila melanogaster as a choice organism in toxicology studies. Drosophila melanogaster model offers several important advantages, such as a relatively simple genome structure, short lifespan, low maintenance cost, readiness of experimental manipulation comparative to vertebrate models from both ethical and technical points of view, relevant gene homology with higher organisms, and ease of obtaining mutant phenotypes. The molecular pathways, as well as multiple behavioral and developmental parameters, can be evaluated using this model in lower, medium or high throughput type assays, allowing a systematic classification of the toxicity levels of different nanomaterials. The purpose of this paper is to review the current research on the applications of Drosophila melanogaster model for the in vivo assessment of nanoparticles toxicity and to reveal the huge potential of this model system to provide results that could enable a proper selection of different nanostructures for a certain biomedical application. PMID:26907252

  1. Living in contained environments: Research implications from undersea habitats. [undersea habitats

    NASA Technical Reports Server (NTRS)

    Helmreich, Robert L.

    1986-01-01

    A cost-reward model is used to frame a discussion of differences in observed behavior of individuals and groups in confined environments. It has been observed that the high cost of functioning in a stressful environment is likely to produce poor performance when anticipated rewards are low but that participants can manage the stress and achieve high performance if they anticipate high rewards. The high-reward environment is exemplified by early undersea habitats such as Sealab and Tektite and by early space missions. Other aspects of behavior occur in all confined environments and point to an important area for future research. Of particular interest are intergroup conflicts arising between the confined group and its external control. Also, individual differences in personality seem always to have an impact in confined environments. Recent research has focused on: (1) predicting performance and adjustment based on instrumental and expressive aspects of the self; (2) the differential predictive power of achievement striving and irritation/irritability in Type A personalities; and (3) the nature and role of leadership in small, isolated groups.

  2. Validity of the Acti4 method for detection of physical activity types in free-living settings: comparison with video analysis.

    PubMed

    Stemland, Ingunn; Ingebrigtsen, Jørgen; Christiansen, Caroline S; Jensen, Bente R; Hanisch, Christiana; Skotte, Jørgen; Holtermann, Andreas

    2015-01-01

    This study examined the ability of the Acti4 software for identifying physical activity types from accelerometers during free-living with different levels of movement complexity compared with video observations. Nineteen aircraft cabin cleaners with ActiGraph GT3X+ accelerometer at the thigh and hip performed one semi-standardised and two non-standardised sessions (outside and inside aircraft) with different levels of movement complexity during working hours. The sensitivity for identifying different activity types was 75.4-99.4% for the semi-standardised session, 54.6-98.5% outside the aircraft and 49.9-90.2% inside the aircraft. The specificity was above 90% for all activities, except 'moving' inside the aircraft. These findings indicate that Acti4 provides good estimates of time spent in different activity types during semi-standardised conditions, and for sitting, standing and walking during non-standardised conditions with normal level of movement complexity. The Acti4 software may be a useful tool for researchers and practitioners in the field of ergonomics, occupational and public health. Practitioner Summary: Being inexpensive, small, water-resistant and without wires, the ActiGraph GT3X+ by applying the Acti4 software may be a useful tool for long-term field measurements of physical activity types for researchers and practitioners in the field of ergonomics, occupational and public health.

  3. Qualitative research and its methods in epilepsy: Contributing to an understanding of patients' lived experiences of the disease.

    PubMed

    Rapport, Frances; Clement, Clare; Doel, Marcus A; Hutchings, Hayley A

    2015-04-01

    This review paper makes the case for the usefulness of qualitative research methods in the context of epilepsy research. It begins with an assessment of the current state of epilepsy literature and identifies gaps especially in the following: research in 'developing' countries and research around surgery for adults with epilepsy. It makes the case that disclosure of people's behaviors, actions, and reactions in different, often complex health-care situations can indicate how they bring meaning to their disease experiences and support needs. It shows the value of encouraging work that clarifies how patients manage their illness and how they understand changes in their health and well-being over the life course of their illness and how health-care professionals and other stakeholder groups care for those with epilepsy. The paper suggests a range of methods for addressing gaps in the literature and highlights a range of data collection, data analysis, and data interpretation and synthesis techniques that are appropriate in this context. It pays particular attention to the strengths of qualitative applications in mixed-methods research using an example from a recent ulcerative colitis drug trial that indicates how they can be integrated into study findings, add rich description, and enhance study outcomes. Ethnographic methodology is also presented, as a way of offering rare access to the 'lived experience' dimension, before the paper concludes with an assessment of the qualitative criteria of credibility, dependability, transferability, and confirmability for judging a study's 'trustworthiness'. The criteria evidence not only the trustworthiness of data and findings but also the ways in which a study has approached any challenges inherent in its research design.

  4. More Active Living-oriented County and Municipal Zoning is Associated with Increased Adult Leisure Time Physical Activity-United States, 2011.

    PubMed

    Chriqui, Jamie F; Nicholson, Lisa M; Thrun, Emily; Leider, Julien; Slater, Sandy J

    2016-01-01

    Although zoning is recognized for its role in facilitating healthy communities, no study has examined whether active living-oriented zoning codes are associated with adult leisure time physical activity (PA). This study sought to fill this gap and hypothesized that adult leisure time PA would be greater in communities with more progressive zoning code reforms and more active living-oriented zoning. Zoning codes for 1,617 county and municipal jurisdictions located in 30 states (covering ~40% of the U.S. population) were evaluated for code reform zoning and 11 active living markers. County-aggregated zoning measures were created for linking with five adult PA behaviors obtained from the 2011 Behavioral Risk Factor Surveillance System controlling for individual and county sociodemographics. Zoning elements most associated with adult PA included requirements for mixed use, active and passive recreation, bike parking/street furniture, and bike-pedestrian trails/paths. This study provides new insights as to the role that zoning can play in facilitating adult PA.

  5. Client satisfaction. Operations research activities and results.

    PubMed

    1998-06-01

    Operations research (OR) is a major component of the Quality Assurance Project's (QAP) strategy for improving the quality of health care delivery worldwide. QAP's Operations Research Program aims to improve the feasibility, utility, and cost-effectiveness of quality assurance strategies in developing countries. QAP and its field partners work to maximize the utility of each field study's findings. As such, the project hopes to disseminate information on all aspects of important OR projects, from the initial design to implementation and results. Over the course of the project, QAP's staff and their partners will develop studies in 16 technical areas. One key area of interest is the study of client satisfaction with health care delivery. The project currently has two major studies on client satisfaction underway in Niger and Peru. Phase one results from the Niger research and QAP and the Max Salud Institute in Peru are discussed.

  6. Boost-phase discrimination research activities

    NASA Technical Reports Server (NTRS)

    Cooper, David M.; Deiwert, George S.

    1989-01-01

    Theoretical research in two areas was performed. The aerothermodynamics research focused on the hard-body and rocket plume flows. Analytical real gas models to describe finite rate chemistry were developed and incorporated into the three-dimensional flow codes. New numerical algorithms capable of treating multi-species reacting gas equations and treating flows with large gradients were also developed. The computational chemistry research focused on the determination of spectral radiative intensity factors, transport properties and reaction rates. Ab initio solutions to the Schrodinger equation provided potential energy curves transition moments (radiative probabilities and strengths) and potential energy surfaces. These surfaces were then coupled with classical particle reactive trajectories to compute reaction cross-sections and rates.

  7. Living with a Star: New Opportunities in Sun-Climate Research

    NASA Technical Reports Server (NTRS)

    Eddy, John Allen

    2003-01-01

    Enormous advances have been made in the last quarter century in all of these needed areas, covering the two essential halves of the Sun-Climate question: in what we know of solar variations and, equally important, in what we know of the climate system and of climatic changes. These research achievements allow us to examine all aspects of the question more directly and quantitatively than was ever possible before, and in the brighter light and more objective context of other known or suspected climate change mechanisms, including human-induced global greenhouse warming. Brief summaries of present status and current understanding are given below for nine facets of Sun-Climate science in which major progress has been made in recent years. At the same time it will be seen that in every instance, significant elements of uncertainty still remain, Some of the most important of these unanswered questions are considered later, in Section IV.

  8. Research suggests that one in two women, possibly more, experience violence in their lives.

    PubMed

    1999-03-01

    This editorial discusses domestic violence, which is the main topic of articles in this issue of Links. All contributing authors participated in Oxfam's workshop on violence against women held in Sarajevo. The workshop included 60 women from 25 countries who shared experiences and exchanged strategies for overcoming violence against women. Plans in 1999 include the domestic violence meeting in March of the Preparatory Committee for the International Criminal Court (ICC). Progress in changing social acceptance of domestic violence and in changing laws will depend upon governments' willingness to sign UN conventions and withdraw reservations. The UN Commission on the Status of Women will meet to review and appraise implementation of the Beijing Plan of Action. Oxfam has been active in pressuring the ICC to prosecute all forms of sexual violence as war crimes and as crimes against humanity. The first such prosecution in a Rwanda case is included in this issue. This issue also includes articles that reveal the experiences of women's organizations which are active in ending violence against women. These groups have used awareness-raising strategies, information gathering, lobbying for the creation and implementation of national and international laws, and establishment of services such as shelters and telephone support lines. The common thread regardless of country of origin is the suffering in silence and sense of isolation experienced by victims of violence and the difficulty of leaving violent domestic situations due to traditional values and social structures.

  9. Freshly induced short-lived gamma-ray activity as a measure of fission rates in lightly re-irradiated spent fuel

    NASA Astrophysics Data System (ADS)

    Kröhnert, H.; Perret, G.; Murphy, M. F.; Chawla, R.

    2010-12-01

    A new measurement technique has been developed to determine fission rates in burnt fuel, following re-irradiation in a zero-power research reactor. The development has been made in the frame of the LIFE@PROTEUS program at the Paul Scherrer Institute, which aims at characterizing the interfaces between fresh and highly burnt fuel assemblies in modern LWRs. To discriminate against the high intrinsic gamma-ray activity of the burnt fuel, the proposed measurement technique uses high-energy gamma-rays, above 2000 keV, emitted by short-lived fission products freshly produced in the fuel. To demonstrate the feasibility of this technique, a fresh UO 2 sample and a 36 GWd/t burnt UO 2 sample were irradiated in the PROTEUS reactor and their gamma-ray activities were recorded directly after irradiation. For both fresh and the burnt fuel samples, relative fission rates were derived for different core positions, based on the short-lived 142La (2542 keV), 89Rb (2570 keV), 138Cs (2640 keV) and 95Y (3576 keV) gamma-ray lines. Uncertainties on the inter-position fission rate ratios were mainly due to the uncertainties on the net-area of the gamma-ray peaks and were about 1-3% for the fresh sample, and 3-6% for the burnt one. Thus, for the first time, it has been shown that the short-lived gamma-ray activity, induced in burnt fuel by irradiation in a zero-power reactor, can be used as a quantitative measure of the fission rate. For both fresh and burnt fuel, the measured results agreed, within the uncertainties, with Monte Carlo (MCNPX) predictions.

  10. Active subjects of passive monitoring: responses to a passive monitoring system in low-income independent living

    PubMed Central

    BERRIDGE, CLARA

    2016-01-01

    Passive monitoring technology is beginning to be reimbursed by third-party payers in the United States of America. Given the low voluntary uptake of these technologies on the market, it is important to understand the concerns and perspectives of users, former users and non-users. In this paper, the range of ways older adults relate to passive monitoring in low-income independent-living residences is presented. This includes experiences of adoption, non-adoption, discontinuation and creative ‘misuse’. The analysis of interviews reveals three key insights. First, assumptions built into the technology about how older adults live present a problem for many users who experience unwanted disruptions and threats to their behavioural autonomy. Second, resident response is varied and challenges the dominant image of residents as passive subjects of a passive monitoring system. Third, the priorities of older adults (e.g. safety, autonomy, privacy, control, contact) are more diverse and multi-faceted than those of the housing organisation staff and family members (e.g. safety, efficiency) who drive the passive monitoring intervention. The tension between needs, desires and the daily lives of older adults and the technological solutions offered to them is made visible by their active responses, including resistance to them. This exposes the active and meaningful qualities of older adults’ decisions and practices. PMID:28239211

  11. Active subjects of passive monitoring: responses to a passive monitoring system in low-income independent living.

    PubMed

    Berridge, Clara

    2017-03-01

    Passive monitoring technology is beginning to be reimbursed by third-party payers in the United States of America. Given the low voluntary uptake of these technologies on the market, it is important to understand the concerns and perspectives of users, former users and non-users. In this paper, the range of ways older adults relate to passive monitoring in low-income independent-living residences is presented. This includes experiences of adoption, non-adoption, discontinuation and creative 'misuse'. The analysis of interviews reveals three key insights. First, assumptions built into the technology about how older adults live present a problem for many users who experience unwanted disruptions and threats to their behavioural autonomy. Second, resident response is varied and challenges the dominant image of residents as passive subjects of a passive monitoring system. Third, the priorities of older adults (e.g. safety, autonomy, privacy, control, contact) are more diverse and multi-faceted than those of the housing organisation staff and family members (e.g. safety, efficiency) who drive the passive monitoring intervention. The tension between needs, desires and the daily lives of older adults and the technological solutions offered to them is made visible by their active responses, including resistance to them. This exposes the active and meaningful qualities of older adults' decisions and practices.

  12. The Relationship between Activities of Daily Living and Life Satisfaction in the Elderly: Active Engagement as Compared to Passive Participation.

    ERIC Educational Resources Information Center

    Iannuzzelli, Jena; England, Eileen M.

    Daily activities and social contact were studied as influences on the life satisfaction of elderly people. It was considered that all activities might not be equal and that individuals who participate in more active activities and who have more active social contacts would score higher in life satisfaction than those who engage in inactive…

  13. Characteristics of the Colombian armed conflict and the mental health of civilians living in active conflict zones

    PubMed Central

    2012-01-01

    Background Despite the fact that the Colombian armed conflict has continued for almost five decades there is still very little information on how it affects the mental health of civilians. Although it is well established in post-conflict populations that experience of organised violence has a negative impact on mental health, little research has been done on those living in active conflict zones. Médecins Sans Frontières provides mental health services in areas of active conflict in Colombia and using data from these services we aimed to establish which characteristics of the conflict are most associated with specific symptoms of mental ill health. Methods An analysis of clinical data from patients (N = 6,353), 16 years and over, from 2010–2011, who consulted in the Colombian departments (equivalent to states) of Nariño, Cauca, Putumayo and Caquetá. Risk factors were grouped using a hierarchical cluster analysis and the clusters were included with demographic information as predictors in logistic regressions to discern which risk factor clusters best predicted specific symptoms. Results Three clear risk factor clusters emerged which were interpreted as ‘direct conflict related violence’, ‘personal violence not directly conflict-related’ and ‘general hardship’. The regression analyses indicated that conflict related violence was more highly related to anxiety-related psychopathology than other risk factor groupings while non-conflict violence was more related to aggression and substance abuse, which was more common in males. Depression and suicide risk were represented equally across risk factor clusters. Conclusions As the largest study of its kind in Colombia it demonstrates a clear impact of the conflict on mental health. Among those who consulted with mental health professionals, specific conflict characteristics could predict symptom profiles. However, some of the highest risk outcomes, like depression, suicide risk and aggression, were more

  14. Realist evaluation of intersectoral oral health promotion interventions for schoolchildren living in rural Andean communities: a research protocol

    PubMed Central

    Talbot, Lise R; Gaboury, Isabelle

    2017-01-01

    Background Intersectoral collaboration, known to promote more sustainable change within communities, will be examined in an oral health promotion program (OHPP). In Peru, an OHPP was implemented by the Ministry of Health, to reduce the incidence of caries in schoolchildren. In rural Andean communities, however, these initiatives achieved limited success. The objectives of this project are: (1) to understand the context and the underlying mechanisms associated with Peruvian OHPP's current effects among school children living in rural Andean communities and (2) to validate a theory explaining how and under which circumstances OHP intersectoral interventions on schoolchildren living in rural Andean communities produce their effects. Methods and analysis Through a realist evaluation, the context, underlying mechanisms and programme outcomes will be identified. This process will involve five different steps. In the first and second steps, a logic model and an initial theory are developed. In the third step, data collection will permit measurement of the OHHP's outcomes with quantitative data, and exploration of the elements of context and the mechanisms with qualitative data. In the fourth and fifth steps, iterative data analysis and a validation process will allow the identification of Context-Mechanism-Outcome configuration, and validate or refine the initial theory. Ethics and dissemination This research project has received approval from the Comité d’éthique de la recherche en santé chez l'humain du Centre hospitalier universitaire de Sherbrooke. The initial theory and research results will be published in relevant journals in public health and oral health. They will also be presented at realist evaluation and health promotion international conferences. PMID:28237962

  15. Living with chronic low back pain: a metasynthesis of qualitative research.

    PubMed

    Snelgrove, Sherrill; Liossi, Christina

    2013-12-01

    OBJECTIVES The purpose of this qualitative metasynthesis is to articulate the knowledge gained from a review of qualitative studies of patients' experiences of chronic low back pain. METHODS Meta-ethnographic methodology guided the review of 33 articles representing 28 studies published in English in peer-reviewed journals between 2000 and 2012. A systematic comparison of the main themes from each study was conducted and 'synthesised' to create superordinate themes. RESULTS Three overarching interrelated themes were identified: the impact of chronic low back pain on self; relationships with significant others that incorporated two streams - health professionals and the organisation of care and relationships with family and friends; coping with chronic low back pain. Coping strategies were predominantly physical therapies, medication and avoidance behaviours with very few successful strategies reported. Professional and family support, self-efficacy, motivation, work conditions and exercise opportunities influenced pain experiences. Review authors' recommendations included psychological therapies, education, the facilitation of self-management strategies and support groups. DISCUSSION The review substantiates chronic low back pain as complex, dynamic and multidimensional, underpinned by experiences of persistent distressing pain, loss, and lowered self-worth, stigma, depression, premature aging, fear of the future. Future research should address the paucity of longitudinal studies, loss and issues of ethnicity, gender, ageing.

  16. Perceptions of participating in high-intensity functional exercise among older people dependent in activities of daily living (ADL).

    PubMed

    Lindelöf, N; Rosendahl, E; Gustafsson, S; Nygaard, J; Gustafson, Y; Nyberg, L

    2013-01-01

    The purpose of the study was to evaluate how older people, dependent in ADL perceive their participation in a high-intensity, functional exercise program compared to the perceptions of those participating in a control activity. Forty-eight older people living in residential care facilities answered a questionnaire about their perceptions of participating in an activity for three months. They were aged 65-98, had a mean score of 24 on Mini Mental State Examination (MMSE) and 14 on Barthel ADL Index. The participants had been randomized to exercise (n=20) or control activity (n=28). Differences in responses between exercise and control activity were evaluated using logistic and ordinal regression analyses. The results show that a majority of the exercise group perceived positive changes in lower limb strength, balance, and in the ability to move more safely and securely compared to a minority of the control group (p<0.001). Significantly more respondents in the exercise activity answered that they felt less tired due to the activity (p=0.027) and that they prioritized this activity above other activities (p=0.010). More exercise participants reported that meeting for three months was too short, and fewer that it was too long compared to the control group (p=0.038). This study shows that older people living in residential care facilities, dependent in ADL, and with mild or no cognitive impairment had positive perceptions about participating in high-intensity functional exercise. The findings support the use of a high-intensity exercise program in this population of older people.

  17. Methods to Measure Physical Activity Behaviors in Health Education Research

    ERIC Educational Resources Information Center

    Fitzhugh, Eugene C.

    2015-01-01

    Regular physical activity (PA) is an important concept to measure in health education research. The health education researcher might need to measure physical activity because it is the primary measure of interest, or PA might be a confounding measure that needs to be controlled for in statistical analysis. The purpose of this commentary is to…

  18. Research activities of the Geodynamics Branch

    NASA Technical Reports Server (NTRS)

    Kahn, W. D. (Editor); Cohen, S. C. (Editor)

    1984-01-01

    A broad spectrum of geoscience disciplines including space geodesy, geopotential field modeling, tectonophysics, and dynamic oceanography are discussed. The NASA programs, include the Geodynamics and Ocean Programs, the Crustal Dynamics Project, the proposed Ocean Topography Experiment (TOPEX), and the Geopotential Research Mission (GRM). The papers are grouped into chapters on Crustal Movements, Global Earth Dynamics, Gravity Field Model Development, Sea Surface Topography, and Advanced Studies.

  19. PREFACE: 9th International Fröhlich's Symposium: Electrodynamic Activity of Living Cells (Including Microtubule Coherent Modes and Cancer Cell Physics)

    NASA Astrophysics Data System (ADS)

    Cifra, Michal; Pokorný, Jirí; Kucera, Ondrej

    2011-12-01

    This volume contains papers presented at the International Fröhlich's Symposium entitled 'Electrodynamic Activity of Living Cells' (1-3 July 2011, Prague, Czech Republic). The Symposium was the 9th meeting devoted to physical processes in living matter organized in Prague since 1987. The hypothesis of oscillation systems in living cells featured by non-linear interaction between elastic and electrical polarization fields, non-linear interactions between the system and the heat bath leading to energy downconversion along the frequency scale, energy condensation in the lowest frequency mode and creation of a coherent state was formulated by H Fröhlich, founder of the theory of dielectric materials. He assumed that biological activity is based not only on biochemical but also on biophysical mechanisms and that their disturbances form basic links along the cancer transformation pathway. Fröhlich outlined general ideas of non-linear physical processes in biological systems. The downconversion and the elastic-polarization interactions should be connected in a unified theory and the solution based on comprehensive non-linear characteristics. Biochemical and genetic research of biological systems are highly developed and have disclosed a variety of cellular and subcellular structures, chemical reactions, molecular information transfer, and genetic code sequences - including their pathological development. Nevertheless, the cancer problem is still a big challenge. Warburg's discovery of suppressed oxidative metabolism in mitochondria in cancer cells suggested the essential role of physical mechanisms (but his discovery has remained without impact on cancer research and on the study of physical properties of biological systems for a long time). Mitochondria, the power plants of the cell, have several areas of activity-oxidative energy production is connected with the formation of a strong static electric field around them, water ordering, and liberation of non

  20. Human Research Program Science Management: Overview of Research and Development Activities

    NASA Technical Reports Server (NTRS)

    Charles, John B.

    2007-01-01

    An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews