Science.gov

Sample records for active union members

  1. Union Members Are Community Members

    ERIC Educational Resources Information Center

    Gray, David

    2013-01-01

    Unions serve their members' interests. But union members are also community members, and their interests go well beyond increasing pay and benefits. A local union president has found that his members are best served by participating in a community-wide coalition. Providing eyeglasses to needy students, promoting healthy eating, and increasing…

  2. Teacher Union Legitimacy: Shifting the Moral Center for Member Engagement

    ERIC Educational Resources Information Center

    Popiel, Kara

    2013-01-01

    This mixed-method case study explored teacher union members' beliefs about the teacher union and their reasons for being active or inactive in the union. Findings suggest that teacher unions have gained pragmatic and cognitive legitimacy (Chaison and Bigelow in Unions and legitimacy. Cornell University Press, Ithaca, NY, 2002), but that…

  3. Understanding Militant Teacher Union Members' Activities in Secondary Schools

    ERIC Educational Resources Information Center

    Mahlangu, Vimbi P.

    2013-01-01

    This article investigates the activities of teacher unions in some Gauteng secondary schools in South Africa. The methods used in collecting data were questionnaires, interviews and a literature study of appropriate educational and labour law journals, books and newspapers. An interpretive paradigm was used in analysing the data. In this article,…

  4. What Motivates Member Donations to the Union?

    NASA Astrophysics Data System (ADS)

    Austin, James A.; Grove, Timothy L.

    2008-04-01

    In the fall of 2007, the AGU Development Board commissioned the development staff to survey the approximately 1200 AGU supporting members to learn why these members give $100 to AGU each year- many give much more-to fund activities in education, public affairs, public information, the sections, and the focus groups. (A recent list of supporting members was published in Eos, 88(49), 544-545, 2007.) With supporting membership having more than doubled since 2003, the development staff and the Development Board wanted to find out more about the individual motivations underlying this trend. We also were trying to identify new incentives for members to support the Union's special projects and programs.

  5. A Union Member's Guide to Employee Involvement.

    ERIC Educational Resources Information Center

    Juravich, Tom; Harris, Howard

    This guide is intended to be a first-time, general introduction to employee involvement for trade unionists--local leaders, stewards, and rank-and-file members. It makes no attempt to be comprehensive, but instead raises the major issues concerning employee involvement framed in trade union terms. Part I looks at the kinds of employee involvement…

  6. Sport for All? Insight into Stratification and Compensation Mechanisms of Sporting Activity in the 27 European Union Member States

    ERIC Educational Resources Information Center

    Van Tuyckom, Charlotte; Scheerder, Jeroen

    2010-01-01

    Physical activity is an important public health issue and the benefits of an active lifestyle in relation to well-being and health have been strongly emphasised in recent years in Europe, as well as in most parts of the world. However, previous research has shown that physical activity within Europe and its member states is stratified. The present…

  7. A Small College in Maryland Trains Union Members

    ERIC Educational Resources Information Center

    Ashburn, Elyse

    2006-01-01

    The National Labor College was created to increase educational opportunities for union members, and its bachelor's-degree programs, like labor studies and the political economy of labor, focus on material that is immediately applicable to workers' day-to-day union roles. The idea is to make those blue-collar workers more effective at negotiating,…

  8. 12 CFR 701.3 - Member inspection of credit union books, records, and minutes.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Member inspection of credit union books... inspection of credit union books, records, and minutes. (a) Member inspection rights. A group of members of a...) Accounting books and records; and (2) Minutes of the proceedings of the credit union's members, board...

  9. 12 CFR 701.3 - Member inspection of credit union books, records, and minutes.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Member inspection of credit union books... inspection of credit union books, records, and minutes. (a) Member inspection rights. A group of members of a...) Accounting books and records; and (2) Minutes of the proceedings of the credit union's members, board...

  10. 12 CFR 701.3 - Member inspection of credit union books, records, and minutes.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Member inspection of credit union books... inspection of credit union books, records, and minutes. (a) Member inspection rights. A group of members of a...) Accounting books and records; and (2) Minutes of the proceedings of the credit union's members, board...

  11. 12 CFR 701.3 - Member inspection of credit union books, records, and minutes.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Member inspection of credit union books... inspection of credit union books, records, and minutes. (a) Member inspection rights. A group of members of a...) Accounting books and records; and (2) Minutes of the proceedings of the credit union's members, board...

  12. Labor union members play an OLG repeated game

    PubMed Central

    Kandori, Michihiro; Obayashi, Shinya

    2014-01-01

    Humans are capable of cooperating with one another even when it is costly and a deviation provides an immediate gain. An important reason is that cooperation is reciprocated or rewarded and deviations are penalized in later stages. For cooperation to be sustainable, not only must rewards and penalties be strong enough but individuals should also have the right incentives to provide rewards and punishments. Codes of conduct with such properties have been studied extensively in game theory (as repeated game equilibria), and the literature on the evolution of cooperation shows how equilibrium behavior might emerge and proliferate in society. We found that community unions, a subclass of labor unions that admits individual affiliations, are ideal to corroborate these theories with reality, because (i) their activities are simple and (ii) they have a structure that closely resembles a theoretical model, the overlapping generations repeated game. A detailed case study of a community union revealed a possible equilibrium that can function under the very limited observability in the union. The equilibrium code of conduct appears to be a natural focal point based on simple heuristic reasoning. The union we studied was created out of necessity for cooperation, without knowing or anticipating how cooperation might be sustained. The union has successfully resolved about 3,000 labor disputes and created a number of offspring. PMID:25024211

  13. Labor union members play an OLG repeated game.

    PubMed

    Kandori, Michihiro; Obayashi, Shinya

    2014-07-22

    Humans are capable of cooperating with one another even when it is costly and a deviation provides an immediate gain. An important reason is that cooperation is reciprocated or rewarded and deviations are penalized in later stages. For cooperation to be sustainable, not only must rewards and penalties be strong enough but individuals should also have the right incentives to provide rewards and punishments. Codes of conduct with such properties have been studied extensively in game theory (as repeated game equilibria), and the literature on the evolution of cooperation shows how equilibrium behavior might emerge and proliferate in society. We found that community unions, a subclass of labor unions that admits individual affiliations, are ideal to corroborate these theories with reality, because (i) their activities are simple and (ii) they have a structure that closely resembles a theoretical model, the overlapping generations repeated game. A detailed case study of a community union revealed a possible equilibrium that can function under the very limited observability in the union. The equilibrium code of conduct appears to be a natural focal point based on simple heuristic reasoning. The union we studied was created out of necessity for cooperation, without knowing or anticipating how cooperation might be sustained. The union has successfully resolved about 3,000 labor disputes and created a number of offspring. PMID:25024211

  14. 12 CFR 220.110 - Assistance by Federal credit union to its members.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 3 2014-01-01 2014-01-01 false Assistance by Federal credit union to its...) Interpretations § 220.110 Assistance by Federal credit union to its members. (a) An inquiry was presented recently... credit union to aid its members in purchasing stock of a corporation whose subsidiary apparently was...

  15. 12 CFR 220.110 - Assistance by Federal credit union to its members.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 3 2013-01-01 2013-01-01 false Assistance by Federal credit union to its...) Interpretations § 220.110 Assistance by Federal credit union to its members. (a) An inquiry was presented recently... credit union to aid its members in purchasing stock of a corporation whose subsidiary apparently was...

  16. 12 CFR 701.3 - Member inspection of credit union books, records, and minutes.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... substantial financial harm; (3) That portion contains nonpublic personal information as defined in 12 CFR 1016... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Member inspection of credit union books... inspection of credit union books, records, and minutes. (a) Member inspection rights. A group of members of...

  17. 12 CFR 220.110 - Assistance by Federal credit union to its members.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 3 2012-01-01 2012-01-01 false Assistance by Federal credit union to its... Assistance by Federal credit union to its members. (a) An inquiry was presented recently concerning the application of this part or part 221 of this subchapter, to a plan proposed by a Federal credit union to...

  18. 12 CFR 723.16 - What is the aggregate member business loan limit for a credit union?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... limit for a credit union? 723.16 Section 723.16 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... limit for a credit union? (a) General. The aggregate limit on a credit union's net member business loan balances is the lesser of 1.75 times the credit union's net worth or 12.25% of the credit union's......

  19. 12 CFR 723.16 - What is the aggregate member business loan limit for a credit union?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... limit for a credit union? 723.16 Section 723.16 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... limit for a credit union? (a) General. The aggregate limit on a credit union's net member business loan balances is the lesser of 1.75 times the credit union's net worth or 12.25% of the credit union's......

  20. 12 CFR 723.16 - What is the aggregate member business loan limit for a credit union?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... limit for a credit union? 723.16 Section 723.16 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... limit for a credit union? (a) General. The aggregate limit on a credit union's net member business loan balances is the lesser of 1.75 times the credit union's net worth or 12.25% of the credit union's......

  1. 12 CFR 723.16 - What is the aggregate member business loan limit for a credit union?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... limit for a credit union? 723.16 Section 723.16 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... limit for a credit union? (a) General. The aggregate limit on a credit union's net member business loan balances is the lesser of 1.75 times the credit union's net worth or 12.25% of the credit union's......

  2. 12 CFR 723.16 - What is the aggregate member business loan limit for a credit union?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... limit for a credit union? 723.16 Section 723.16 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... limit for a credit union? (a) General. The aggregate limit on a credit union's net member business loan balances is the lesser of 1.75 times the credit union's net worth or 12.25% of the credit union's......

  3. 12 CFR 220.110 - Assistance by Federal credit union to its members.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Assistance by Federal credit union to its... Assistance by Federal credit union to its members. (a) An inquiry was presented recently concerning the... its members in purchasing stock of a corporation whose subsidiary apparently was the employer of...

  4. 12 CFR 220.110 - Assistance by Federal credit union to its members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Assistance by Federal credit union to its... Assistance by Federal credit union to its members. (a) An inquiry was presented recently concerning the... its members in purchasing stock of a corporation whose subsidiary apparently was the employer of...

  5. A Phenomenological Inquiry into the Financial Education Experiences of Young, Low-Income Credit Union Members

    ERIC Educational Resources Information Center

    Santangelo, Dan

    2012-01-01

    This qualitative phenomenological study engaged 20 young, low-income credit union members who participated in financial education classes at Denver Community Credit Union. The study explored learning experiences that generated changes in money management behaviors and sought evidence of transformational learning in a nonformal education setting.…

  6. Hospital union election activity, 1974-85

    PubMed Central

    Becker, Edmund R.; Rakich, Jonathon S.

    1988-01-01

    This study, using National Labor Relations Board data and American Hospital Association data, reports on the status of union election activity in the hospital industry for a 65-month period, January 1980-May 1985, and contrasts it with earlier data for a similar 65-month time period (1974-79). Together these data provide a comprehensive overview of union election activity in non-Federal, nongovernment hospitals since the passage of the 1974 Nonprofit Hospital Amendments to the Taft-Hartley Act. The study analyzes union, election, hospital, and environmental characteristics. Comparisons over the two time periods show that, while union victory rates in hospital elections have remained constant, the total number of elections has declined dramatically in the hospital industry. PMID:10312518

  7. Educational Activities of the European Geosciences Union

    NASA Astrophysics Data System (ADS)

    Laj, C.

    2004-12-01

    The Committee on Education of the European Geosciences Union has been created in 2002 and is now composed by 13 members from France, Germany, Great Britain, Italy, Poland, Spain and Sweden. One of the first activities of the CE has been the organization of workshops for secondary school teachers to be held during the annual General Assembly of EGU. Inspired by the AGU GIFT workshops, the EGU workshops differ from the American ones on their international aspect: - First, the audience (about 50 teachers) is entirely international, composed of teachers from all over Europe and not limited to teachers from the geographical area around Nice, where the two first workshops were held. - Second, the program of the workshops have been constructed to give the teachers not only an opportunity to upgrade their knowledge in important scientific topics, but also to exchange information with colleagues about the different school programs in different European countries. In 2004, for instance, the general theme of the 2-days workshop was "The Ocean" and the program consisted of a mixture of topical talks by leading scientists in the field (2/3 of the time) and informal talks/program presentations by the teachers themselves and the science educators present at the workshop (1/3 of the time), resulting in lively exchanges and future collaborations between teachers. Different aspects of this workshop will be described as well as other present and future activities of the Committee on Education of the EGU.

  8. Phosphorus flows and balances of the European Union Member States.

    PubMed

    van Dijk, Kimo C; Lesschen, Jan Peter; Oenema, Oene

    2016-01-15

    Global society faces serious "phosphorus challenges" given the scarcity, essentiality, unequal global distribution and, at the same time, regional excess of phosphorus (P). Phosphorus flow studies can be used to analyze these challenges, providing insight into how society (re)uses and loses phosphorus, identifying potential solutions. Phosphorus flows were analyzed in detail for EU-27 and its Member States. To quantify food system and non-food flows, country specific data and historical context were considered. The sectors covered were crop production (CP), animal production (AP), food processing (FP), non-food production (NF) and consumption (HC). The results show that the EU-27 imported 2392 Gg P in 2005, half of which accumulated in agricultural soils (924 Gg) and half was lost as waste (1217 Gg). Net accumulation was 4.9 kg P/ha/year ranging between +23.2 (Belgium) and -2.8 (Slovakia). From the system losses, 54% was lost from HC in diverse waste flows and 28% from FP, mainly through incinerated slaughter residues. The largest HC losses (655 Gg) were wastewater (55%), food waste (27%), and pet excreta (11%). Phosphorus recycling rates were 73% in AP, 29% in FP, 21% in HC and ~0% in NF. The phosphorus use efficiencies showed that, relative to sector input, about 70% was taken up by crops (CP), 24% was retained in animals (AP), 52% was contained in food products (FP), 76% was stored in non-food materials (NF), and 21% was recycled (HC). Although wide-ranging variation between countries, generally phosphorus use in EU-27 was characterized by relatively (1) large dependency on (primary) imports, (2) long-term accumulation in agricultural soils, especially in west European countries, (3) leaky losses throughout entire society, especially emissions to the environment and sequestered waste, (4) little recycling with the exception of manure, and (5) low use efficiencies, because of aforementioned issues, providing ample opportunities for improvement. PMID:26421756

  9. Multilevel Governance and Shared Sovereignty: European Union, Member States, and the FCTC

    PubMed Central

    MAMUDU, HADII M.; STUDLAR, DONLEY T.

    2010-01-01

    The Westphalian idea of sovereignty in international relations has undergone recent transformation. “Shared sovereignty” through multilevel governance describes the responsibility of the European Union (EU) and its Member States in tobacco control policy. We examine how this has occurred on the EU level through directives and recommendations, accession rules for new members, tobacco control campaigns, and financial support for antitobacco nongovernmental organizations. In particular, the negotiation and ratification of the Framework Convention on Tobacco Control (FCTC) and the participation in the FCTC Conference of the Parties illustrates shared sovereignty. The EU Commission was the lead negotiator for Member States on issues over which it had jurisdiction, while individual Member States, through the EU presidency, could negotiate on issues on which authority was divided or remained with them. Shared sovereignty through multilevel governance has become the norm in the tobacco control policy area for EU members, including having one international organization negotiate within the context of another. PMID:20622934

  10. Mobbing in Bosnia and Herzegovina and the member states of the European Union

    NASA Astrophysics Data System (ADS)

    Rodic, V.

    2016-08-01

    Mobbing as a specific form of discrimination which applies only to the labor law, is a very young branch of labor law. It began to develop during the eighties of last century. This kind of psychoterror that appears in the workplace, was first spotted, formulated and diagnosed by the Swedish psychologist of German origin prof. Dr. Heinz Lejman (Heinz Leymann July 17, 1932.; Wolfenbuttel, Germany - 1999 Stockholm, Sweden). Today, the legal regulation of mobbing in terms of prevention, rules of behavior and sanctions is indispensable to every modern democratic state. I'll make a comparison of the legislative regulation provided by BiH with several European Union member states. I will compare the results of a survey conducted by the European Foundation for the Improvement of Living and Working Condition, during the year 2000. In the European Union Member States, with the results of the questionnaire for employees, which I conducted in Bosnia and Herzegovina. The conclusion I came to in this paper is: Bosnia and Herzegovina is lagging behind a lot of European Union member states, both in terms of prevention of mobbing, as well as legislation, that is insufficient to regulate this complex issue. Results of the questionnaire for the employees that I conducted in Bosnia and Herzegovina are devastating and alarming.

  11. [A review of the nutritional management plans in the member states of the European Union].

    PubMed

    Lachat, C; Dehenauw, S; van Camp, J; Matthys, C; Larondelle, Y; Kolsteren, P

    2006-01-01

    Obesity has reached epidemiological proportions in Europe and the burden of diseases attributable to nutrition is substantial. Under the impetus of the World Health Organisation (WHO), member states have been urged to develop national action plans for nutrition and physical activity. This study describes what has been done in terms of nutrition policy at national level in the member states of the European Union right before its enlargement in 2004. It is a critical review of publicly available policy documents on nutrition and physical activity. The background idea was to assist the initiative of the Belgian food industry to play a proactive role in the development of a Belgian nutrition action plan. At the time of writing, in total six out of the fifteen EU member states namely Sweden, Finland, Denmark, France, the Netherlands and the United Kingdom, reported to have an operational national nutrition plan. By the end of the year 2004, another four countries are expected to have their plan finalised. In line with WHO guidelines, all nutrition plans in this study acknowledge the importance of a multidisciplinary approach and promote stakeholder involvement at some point. Most of the plans however, do not elaborate on their specific role and strategies that will be used to do so. It seems that stakeholder mobilisation is largely restricted to the implementation phases. All operational nutrition plans envisage reducing social disparities. Long-established vulnerable groups in society such as pregnant women, children and elderly are targeted. Considerable variability was observed for nutritional objectives and dietary recommendations between the different countries. Nutrition surveillance and monitoring activities seem to vary considerably between the different action plans. None of the countries except Denmark documents the theoretical foundations and development process of their nutritional surveillance system. National nutrition policy in Europe is clearly in a

  12. A Career in College Unions and Student Activities

    ERIC Educational Resources Information Center

    Association of College Unions International (NJ1), 2009

    2009-01-01

    If you are looking for a rewarding career where you can have a positive impact on others, then a career in college unions and student activities may be right for you. The Association of College Unions International (ACUI) created this guide to provide you with a general overview of a career in college unions and student activities. It will…

  13. 20 CFR 638.814 - Lobbying; political activities; unionization.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Lobbying; political activities; unionization... § 638.814 Lobbying; political activities; unionization. No funds provided under the Act may be used in... activity which involves political activities; or (d) For any activity which will assist, promote, or...

  14. 20 CFR 638.814 - Lobbying; political activities; unionization.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Lobbying; political activities; unionization... § 638.814 Lobbying; political activities; unionization. No funds provided under the Act may be used in... activity which involves political activities; or (d) For any activity which will assist, promote, or...

  15. 20 CFR 638.814 - Lobbying; political activities; unionization.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Lobbying; political activities; unionization... § 638.814 Lobbying; political activities; unionization. No funds provided under the Act may be used in... activity which involves political activities; or (d) For any activity which will assist, promote, or...

  16. The healthcare system and provision of oral healthcare in European Union member states. Part 4: Greece.

    PubMed

    Damaskinos, P; Koletsi-Kounari, H; Economou, C; Eaton, K A; Widström, E

    2016-03-11

    This paper presents a description of the healthcare system and how oral healthcare is organised and provided in Greece, a country in a deep economic and social crisis. The national health system is underfunded, with severe gaps in staffing levels and the country has a large private healthcare sector. Oral healthcare has been largely provided in the private sector. Most people are struggling to survive and have no money to spend on general and oral healthcare. Unemployment is rising and access to healthcare services is more difficult than ever. Additionally, there has been an overproduction of dentists and no development of team dentistry. This has led to under or unemployment of dentists in Greece and their migration to other European Union member states, such as the United Kingdom, where over 600 Greek dentists are currently working. PMID:26964601

  17. Yoghurt and probiotic bacteria in dietary guidelines of the member states of the European Union.

    PubMed

    Smug, L N; Salminen, S; Sanders, M E; Ebner, S

    2014-03-01

    Beneficial microbes enter the food supply primarily through fermented foods (largely milks) and addition of probiotics. Fermented milks are a significant component of the diet of some geographical regions, including Europe. The fermentation process serves to preserve safety, nutritional quality and palatability of milk. In addition, the microbes associated with fermented milks and probiotics are associated with human health benefits. However, in the area of health claims only one claim for beneficial microbes has been approved in the European Union, that is for yoghurt to improve lactose tolerance. We searched for health messages that include probiotics or fermented milks in nutrition guidelines and recommendations in thirteen countries of the EU plus Switzerland. Such messages are allowed when they are made by non-commercial government bodies. Our analysis revealed that five EU member states have national nutrition guidelines or recommendations that include either probiotics or fermented milks with live bacteria. This supports that some EU member states recognise health benefits associated with consumption of live microbes, even if commercial marketing claims are not authorised. Harmonisation between recommendations and approved health-claims would benefit consumers and public health. PMID:24463208

  18. Active-member control of precision structures

    NASA Technical Reports Server (NTRS)

    Fanson, J. L.; Blackwood, G. H.; Chu, C. C.

    1989-01-01

    This paper presents the results of closed loop experiments that use piezoelectric active-members to control the flexible motion of a precision truss structure. These experiments are directed toward the development of high performance structural systems as part of the Control/Structure Interaction program at JPL. Order of magnitude reductions in dynamic response are achieved with relatively simple control techniques. The practical implementation of high stiffness, high bandwidth active-members in a precision structure highlights specific issues of importance relating to the modelling and implementation of active-member control.

  19. Assessment of collection schemes for packaging and other recyclable waste in European Union-28 Member States and capital cities.

    PubMed

    Seyring, Nicole; Dollhofer, Marie; Weißenbacher, Jakob; Bakas, Ioannis; McKinnon, David

    2016-09-01

    The Waste Framework Directive obliged European Union Member States to set up separate collection systems to promote high quality recycling for at least paper, metal, plastic and glass by 2015. As implementation of the requirement varies across European Union Member States, the European Commission contracted BiPRO GmbH/Copenhagen Resource Institute to assess the separate collection schemes in the 28 European Union Member States, focusing on capital cities and on metal, plastic, glass (with packaging as the main source), paper/cardboard and bio-waste. The study includes an assessment of the legal framework for, and the practical implementation of, collection systems in the European Union-28 Member States and an in depth-analysis of systems applied in all capital cities. It covers collection systems that collect one or more of the five waste streams separately from residual waste/mixed municipal waste at source (including strict separation, co-mingled systems, door-to-door, bring-point collection and civic amenity sites). A scoreboard including 13 indicators is elaborated in order to measure the performance of the systems with the capture rates as key indicators to identify best performers. Best performance are by the cities of Ljubljana, Helsinki and Tallinn, leading to the key conclusion that door-to-door collection, at least for paper and bio-waste, and the implementation of pay-as-you-throw schemes results in high capture and thus high recycling rates of packaging and other municipal waste. PMID:27357560

  20. Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions.

    PubMed Central

    Wong, O; Morgan, R W; Kheifets, L; Larson, S R; Whorton, M D

    1985-01-01

    A historical prospective mortality study was conducted on a cohort of 34 156 male members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. This cohort comprised all individuals who were members of the International Union of Operating Engineers, Locals 3 and 3A, for at least one year between 1 January 1964 and 31 December 1978. The mortality experience of the entire cohort and several subcohorts was compared with that of United States white men, adjusted for age and calendar time. The comparison statistic was the commonly used standardised mortality ratio (SMR). Historical environmental measurements did not exist, but partial work histories were available for some cohort members through the union dispatch computer tapes. An attempt was made to relate mortality experience to the union members' dispatch histories. Overall mortality for the entire cohort and several subgroups was significantly lower than expected. When cause specific mortality was examined, however, the study provided suggestive evidence for the existence of several potential health problems in this cohort. Mortality from liver cancer for the entire cohort was significantly high. Although mortality from lung cancer for the entire cohort was similar to expected, a positive trend by latency was observed for lung cancer. A significant excess of mortality from lung cancer was found among the retirees and the group for whom no dispatch histories were available. Other dispatch groups showed no evidence of lung cancer excess. In addition, the total cohort experienced significant mortality excess from emphysema and accidental deaths. PMID:2410010

  1. Union activity in hospitals: past, present, and future.

    PubMed

    Becker, E R; Sloan, F A; Steinwald, B

    1982-06-01

    Between 1970 and 1980, the percentage of hospitals with one or more collective bargaining contracts increased from 15.7 percent to 27.4 percent. A substantial amount of variation exists in the extent of unionism on the basis of hospital ownership, bed size, and location. Employees are more likely to organize when hospitals in the State are regulated by a mandatory rate-setting program. Unions raise hospital employee's wages--a modal estimate for RNs is about 6 percent; the corresponding figure for nonprofessional employees is about 10 percent. Growth of union activity in hospitals has generally not been a major contributor to hospital wage inflation, and less than 10 percent of the increase in real (relative to the Consumer Price Index) spending for hospital care that occurred during the 1970s can be attributed to union growth. We project that between 45 and 50 percent of all hospitals will have at least one union by 1990. PMID:10309636

  2. Union Activity in Hospitals: Past, Present, and Future

    PubMed Central

    Becker, Edmund R.; Sloan, Frank A.; Steinwald, Bruce

    1982-01-01

    Between 1970 and 1980, the percentage of hospitals with one or more collective bargaining contracts increased from 15.7 percent to 27.4 percent. A substantial amount of variation exists in the extent of unionism on the basis of hospital ownership, bed size, and location. Employees are more likely to organize when hospitals in the State are regulated by a mandatory rate-setting program. Unions raise hospital employee's wages—a modal estimate for RNs is about 6 percent; the corresponding figure for nonprofessional employees is about 10 percent. Growth of union activity in hospitals has generally not been a major contributor to hospital wage inflation, and less than 10 percent of the increase in real (relative to the Consumer Price Index) spending for hospital care that occurred during the 1970s can be attributed to union growth. We project that between 45 and 50 percent of all hospitals will have at least one union by 1990. PMID:10309636

  3. US - Former Soviet Union environmental management activities

    SciTech Connect

    1995-09-01

    The Office of Environmental Management (EM) has been delegated the responsibility for US DOE`s cleanup of nuclear weapons complex. The nature and the magnitude of the waste management and environmental remediation problem requires the identification of technologies and scientific expertise from domestic and foreign sources. This booklet makes comparisons and describes coordinated projects and workshops between the USA and the former Soviet Union.

  4. Inequality, Poverty, and Material Deprivation in New and Old Members of European Union

    PubMed Central

    Matković, Teo; Šućur, Zoran; Zrinščak, Siniša

    2007-01-01

    Aim To analyze the main indicators of income inequality, objective and subjective poverty, material deprivation, and the role of public social transfers in the reduction of poverty in 15 old and 10 new member states of the European Union (EU), undergoing post-communist socio-economic transition, as well as in Croatia, a candidate EU country. Method Objective poverty rates, poverty reduction rates, poverty thresholds in purchasing power standards (PPS), total social expenditure, inequality indicators, and risks of poverty according to demographics were calculated using the data from the Eurostat databases (in particular, Household Budget Survey). For Croatia, Central Bureau of Statistics first releases on poverty indicators were used, as well as database of the Ministry of Finance (social expenditure). Subjective poverty rates and non-monetary deprivation index were calculated using the European Quality of Life Survey, which was carried out in 2003 in EU countries and in 2006 in Croatia. Results According to the indicators of income inequality and objective poverty, there was a divide among old EU member states (EU15), with UK, Ireland and South European countries having higher and Continental and Nordic countries lower indicators of inequality and poverty. Among new member states (NMS10), Baltic countries and Poland had the highest and Slovenia and the Czech Republic the lowest indicators of inequality and poverty. In all EU15 countries, except Greece, subjective poverty rates were lower than objective ones, whereas in all NMS10 countries the levels of subjective poverty were much higher than those of objective poverty. With some exceptions, NMS10 countries had low or even decreasing social expenditures. The share of respondents who were deprived of more than 50% of items was 6 times higher in the NMS10 than in the EU15 countries. When standard of living was measured by income inequality, relative poverty rates, poverty reduction rates, total social protection

  5. Sex roles in management: the impact of varying power of speech style on union members' perception of satisfaction and effectiveness.

    PubMed

    Geddes, D

    1992-11-01

    Effective management has traditionally been associated with men and masculine characteristics. In this study, I focused on manager communication, specifically the perceived effects of stereotypical gender/power speech styles. Union members viewed and rated a male and a female manager on videotape using three gender/power speech styles: stereotypical masculine (powerful), stereotypical feminine (powerless), and mixed gender/power. Union respondents judged both the male and female manager using the mixed gender/power speech style as most effective and as being associated with the most satisfied employees. PMID:1289503

  6. Mutatis Mutandis? The Court of Justice of the European Union Rules that Member States May Be Allowed to Impose Non-Resident Student Quotas

    ERIC Educational Resources Information Center

    Observatory on Borderless Higher Education, 2010

    2010-01-01

    Earlier this month, the Court of Justice of the European Union (the Court), ruled that European Union (EU) member states can impose non-resident student quotas in certain circumstances. The Court, whose job is to ensure that all EU member states interpret and apply EU legislation in the same way, recently made the ruling in response to a…

  7. The comparative burden of salmonellosis in the European Union member states, associated and candidate countries

    PubMed Central

    de Jong, Birgitta; Ekdahl, Karl

    2006-01-01

    Background Salmonella is an infectious agents causing numerous cases of illness each year, and thereby having significant economic impact. Using returning Swedish travellers we estimated the burden of salmonellosis in different European countries. Methods From the Swedish database on notifiable communicable diseases 15,864 cases with travel-associated salmonellosis acquired in Europe from 1997–2003 were retrieved. These cases were compared to a dataset from the same years on 14,171 randomly selected Swedish residents, with a history of recent overnight travel in Europe. Distribution of salmonellosis in returning travellers and the distribution of Salmonella Enteritidis was analysed for different member states in the European Union, associated and candidate countries. The risk of being notified with a salmonella infection after return from each European country/region was calculated, and compared with official reporting data rom these countries. Using Norway as reference country, we could 1) construct comparable incidence estimates and 2) calculate the "under-reporting" in each country compared to Norway. Results The highest burden of salmonellosis was estimated for Bulgaria (2741/100,000), followed by Turkey with 2344/100 000 and Malta with 2141/100 000. S. Enteritidis is the dominating serotype, 66.9 % of all cases and phage type 4 accounts for 37.5 % of the S. Enteritidis cases Conclusion Using returning tourists as a sentinel population can provide a useful base for comparison of disease burdens in different countries/regions. Focusing prevention of salmonellosis to prevention of egg and poultry associated S. Enteritidis infection will have a major impact from a public health perspective and will significantly lower the burden of disease in most European countries. PMID:16403230

  8. 20 CFR 633.319 - Lobbying, political activities and unionization.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Lobbying, political activities and... Lobbying, political activities and unionization. No funds provided under the Act may be used in any way: (a... oppose any legislation or appropriation by such legislators. (c) Which involves political activities...

  9. 20 CFR 633.319 - Lobbying, political activities and unionization.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Lobbying, political activities and... Lobbying, political activities and unionization. No funds provided under the Act may be used in any way: (a... oppose any legislation or appropriation by such legislators. (c) Which involves political activities...

  10. 20 CFR 633.319 - Lobbying, political activities and unionization.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Lobbying, political activities and... Lobbying, political activities and unionization. No funds provided under the Act may be used in any way: (a... oppose any legislation or appropriation by such legislators. (c) Which involves political activities...

  11. Petrology of Tullock Member, Fort Union Formation, Wyoming and Montana: Evidence for early Paleocene uplift of Bighorn Mountains

    SciTech Connect

    Brown, J.L.; Hansley, P.L. )

    1989-09-01

    New petrologic data collected from sandstones in the Paleocene Tullock Member of the Fort Union Formation above the Cretaceous/Tertiary boundary in the Powder River basin (PRB) and from the lowermost Paleocene in the Bighorn basin, Wyoming and Montana, compel reevaluation of the timing of the bighorn uplift, formerly thought to be middle Paleocene. The Cretaceous/Tertiary boundary is identified by regionally valid palynological and trace element geochemical criteria. Basin-wide outcrop and subsurface studies of the Tullock Member indicate deposition on a low-gradient alluvial plain extending toward the retreating Cannonball sea. Eastward-flowing, low-sinuosity paleostreams containing small, sandy, stable channels characterized the fluvial systems.

  12. Comparison of SMR, PMR, and PCMR in a cohort of union members potentially exposed to diesel exhaust emissions.

    PubMed Central

    Wong, O; Morgan, R W; Kheifets, L; Larson, S R

    1985-01-01

    A comparison of cause specific standarised mortality ratios (SMRs) and proportionate mortality ratios (PMRs) or proportionate cancer mortality ratios (PCMRs) was made based on the mortality experience of a cohort of 34 156 members of a heavy equipment operators union. Two types of PMRs or PCMRs were used in the comparison: those based on all deaths and those based on deaths known to the union only. The comparison indicated that, for the entire cohort, both types of PMRs were poor indicators for cancer risk and produced a large number of false positives. On the other hand, PCMRs appeared to be better than PMRs for assessing the direction of site specific cancer risk, but they tended to overstate the magnitude of risk. Analysis by duration of union membership or latency indicated that PMRs or PCMRs based on deaths known to the union tended to overestimate the risk of lung cancer by disproportionately larger amounts in groups with shorter time than in groups with longer time. This differential bias had the net effect of reducing the gradient of any trend or eliminating the trend entirely. In conclusion, PMR or PCMR, based on reasonably sufficient death ascertainment, has a certain usefulness in generating hypotheses, but they are not useful or reliable in measuring the magnitude of risk or in detecting trends in dose response analysis. No conclusion should be drawn from either PMR or PCMR. PMID:2410011

  13. Volunteer Activities and Their Relationship to Motivational Needs: A Study of the Stamp Union Program Research Report 18-89.

    ERIC Educational Resources Information Center

    Balenger, Victoria J.; And Others

    Volunteer student union programming board members at the University of Maryland, College Park were asked to designate the five programming board activities or experiences that they considered to be the most appealing. Activities and experiences had been previously rated according to how they met motivational needs for achievement, affiliation, or…

  14. Exploring a Monetary Union among Nations through Active Learning

    ERIC Educational Resources Information Center

    Goma, Ophelia D.

    2002-01-01

    This article presents a classroom project that employs various techniques of active learning including role-playing, collaborative group work and writing. The project explores the recent creation of the European Monetary Union (EMU) with special emphasis on the introduction of the euro. The project assumes that the Americas have begun preliminary…

  15. Obtaining health care in another European Union Member State: how easy is it to find relevant information?

    PubMed

    Santoro, Alessio; Silenzi, Andrea; Ricciardi, Walter; McKee, Martin

    2015-02-01

    The European Union Directive on cross-border health care places an obligation on member states (MSs) to establish one or more national contact points (NCPs). We evaluated whether MSs were meeting their legal obligations. Two researchers created a set of criteria, drawn from the Directive, to evaluate the information that 18 MSs provide on their NCP websites. Some 15 of the 18 MSs evaluated provided >75% of the information sought. This report shows examples of best practices that could be used to encourage other MSs to improve the quality and quantity of information provided. PMID:25096256

  16. Teachers Union Organizes Members to Enforce AHERA Law-A Work in Progress.

    PubMed

    Sireci, Michael P; Levenstein, Charles; Gibson, Sarah

    2016-05-01

    The Massachusetts Teachers Association's Environmental Health and Safety Committee is using a number of approaches to evaluate and improve the enforcement of the U.S. Asbestos Hazard Emergency Response Act legislation intended to ensure the proper management of asbestos in public buildings, including schools. The committee first approached state regulators directly concerning enforcement concerns, with limited success. Next, the Massachusetts Teachers Association developed an organizing strategy and a curriculum focusing on the requirements of the Asbestos Hazard Emergency Response Act and on building a membership-run health and safety committee infrastructure in local unions. Five trainings took place throughout Massachusetts over a 2-month period in 2015. The committee implemented follow-up procedures and support for locals to continue to engage in this ongoing effort. This work illustrates that the passage of the Asbestos Hazard Emergency Response Act in 1986 was insufficient action to remediate school asbestos exposures. It is necessary for unions representing school employees to systematically hold regulators and school districts accountable for enforcement and compliance. PMID:26715674

  17. Sedimentary regime of Tullock Member of Fort Union Formation, Tullock Creek type locality, South-central Montana

    SciTech Connect

    Brown, J.L.

    1986-08-01

    The early Paleocene Tullock Member of the Fort Union Formation at its type locality was deposited in a low-gradient riverine system. This interpretation is based on studies of sedimentary structures, geometry, thickness trends, and sand-percent isopach maps. Lithologies consist of interbedded sandstones, siltstones, shales, and thin coal beds. Sandstones 10 m (32.8 ft) thick contain fining-upward, fine-grained, structureless units with erosional bases capped by climbing-ripple lamination. Some sandstones have claystone rip-up clasts at their bases. The sandstones are discrete, highly convex bodies with symmetrical cross sections and flat erosional bases. These sandstone bodies are isolated show no stacking or coalescing, and are concentration in the middle of the Tullock Member. Interbedded calcareous siltstones show ripple cross-laminae and contain elongate calcareous nodules 4 to 16 cm (1.6 to 6.3 in.) long, oriented parallel to the bedding plane. They also contain well-preserved, fragmented leaf impressions. Carbonaceous shale predominates in the upper and lower third of the member. These shales show very thin lamination, contain abundant plant fragments, and have a mottled rooted texture. Thin, discontinuous coal beds are found within the lower third of the Tullock.

  18. The healthcare system and the provision of oral healthcare in European Union member states: Part 5: Romania.

    PubMed

    Oancea, R; Amariei, C; Eaton, K A; Widström, E

    2016-04-01

    Romania is one of the newest member states of the European Union (EU). It has 13 dental schools, 14,841 dentists and 2,935 dental technicians providing oral health care for a population, at 31 December 2014, of 21.3 million. The shift from a communist system to a democratic or capitalist society has contributed to an enormous change in the proportion of public and private sector oral health services. The lack of public funds during the post-communist years has contributed to a dependency on private oral healthcare rather than the government financed public provision. Affordability and social awareness have together established a mixed economy for oral health care costs and oral healthcare is growing slowly compared with other developed EU member states. At the same time, there has been overproduction of new dentists (currently 1500 graduate annually). This has led to un and under-employment and emigration of dentists to other EU member states. This paper explains the current oral healthcare system in Romania and changes in recent years. PMID:27056521

  19. Trade Union Mergers: A Survey of the Literature.

    ERIC Educational Resources Information Center

    Michelson, Grant

    2000-01-01

    Examines trade union mergers highlighting merger forms, merger motivation, role played by union officers, and merger waves. Discusses the consequences of mergers on members and union performance and concludes that union merger activity has had little impact. (Contains 74 references.) (JOW)

  20. Participation of VICA Members in Personal Development Activities.

    ERIC Educational Resources Information Center

    Gordon, Howard R. D.

    A study examined the extent to which 1994-95 members of the West Virginia chapter of Vocational Industrial Clubs of America (VICA) participated in VICA personal development activities. The study population consisted of all VICA members in West Virginia, and the study sample consisted of all 156 VICA members who attended the annual West Virginia…

  1. Competence and Human Resource Development in Multinational Companies in Three European Union Member States: A Comparative Analysis between Austria, the Netherlands and the United Kingdom. CEDEFOP Panorama Series.

    ERIC Educational Resources Information Center

    Markowitsch, Jorg; Kollinger, Iris; Warmerdam, John; Moerel, Hans; Konrad, John; Burell, Catherine; Guile, David

    A comparative analysis of human resources development and management in the subsidiaries of three multinational companies (Xerox, Glaxo Wellcome, and AXA Nordstern Colonia) was conducted in these three European Union (EU) member states: Austria, the United Kingdom, and the Netherlands. Case studies were used, focusing on competence needs and…

  2. Anticipation of Occupation and Qualification Trends in the European Union: Innovations for Effective Anticipation of Qualification and Competence Trends and the Adaptation of VET Provision in Member States.

    ERIC Educational Resources Information Center

    Sellin, Burkart, Ed.

    The approaches being taken and innovations being adopted at the national and European levels to anticipate occupation and qualification trends in the European Union (EU) were examined in a survey of the 15 EU member states. The survey findings were presented by country and in a synthesis. In addition, the findings for Belgium were broken down by…

  3. Measures Taken in the Member States of the European Union To Assist Young People Who Have Left the Education System without Qualifications.

    ERIC Educational Resources Information Center

    EURYDICE European Unit, Brussels (Belgium).

    European Union Member States gather information on students who drop out without qualification so that they may know how to help this population. This report presents the broad range of measures, arrangements, and systems that exist for supervising, monitoring, training, and providing for dropouts. The text defines the categories used for the…

  4. European Sitting Championship: Prevalence and Correlates of Self-Reported Sitting Time in the 28 European Union Member States

    PubMed Central

    Loyen, Anne; van der Ploeg, Hidde P.; Bauman, Adrian; Brug, Johannes; Lakerveld, Jeroen

    2016-01-01

    Objective Sedentary behaviour is increasingly recognized as an important health risk, but comparable data across Europe are scarce. The objective of this study was to explore the prevalence and correlates of self-reported sitting time in adults across and within the 28 European Union Member States. Methods This study reports data from the Special Eurobarometer 412. In 2013, 27,919 randomly selected Europeans (approximately 1000 per Member State) were interviewed face-to-face. Sitting time on a usual day was self-reported and dichotomised into sitting less- and more than 7.5 hours per day. Uni- and multivariate odds ratios of sitting more than 7.5 hours per day were assessed by country and socio-demographic variables using binary logistic regression analyses. The analyses were stratified by country to study the socio-demographic correlates of sitting time within the different countries. Results A total of 26,617 respondents were included in the analyses. Median sitting time was five hours per day. Across Europe, 18.5 percent of the respondents reported to sit more than 7.5 hours per day, with substantial variation between countries (ranging from 8.9 to 32.1 percent). In general, northern European countries reported more sitting than countries in the south of Europe. ‘Current occupation’ and ‘age when stopped education’ were found to be the strongest correlates of sitting time, both across Europe and within most Member States. Compared to manual workers, the odds ratio of sitting more than 7.5 hours per day was 5.00 for people with white collar occupations, 3.84 for students, and 3.65 for managers. Conclusions There is substantial variation in self-reported sitting time among European adults across countries as well as socio-demographic groups. While regular surveillance of (objectively measured) sedentary behaviour is needed, the results of this study provide entry points for developing targeted interventions aimed at highly sedentary populations, such as

  5. NASA Elementary Aerospace Activities Free to Members

    ERIC Educational Resources Information Center

    Journal of Aerospace Education, 1978

    1978-01-01

    Describes the contents of Elementary School Aerospace Activities: A Resource for Teachers. Activities examine a variety of topics in aerospace education and are intended to be used with children ages 5-11. The book is available from the Government Printing Office (GPO) for $3.00. (CP)

  6. Development of magnetostrictive active members for control of space structures

    NASA Technical Reports Server (NTRS)

    Johnson, Bruce G.; Avakian, Kevin M.; Fenn, Ralph C.; Gaffney, Monique S.; Gerver, Michael J.; Hawkey, Timothy J.; Boudreau, Donald J.

    1992-01-01

    The goal of this Phase 2 Small Business Innovative Research (SBIR) project was to determine the technical feasibility of developing magnetostrictive active members for use as truss elements in space structures. Active members control elastic vibrations of truss-based space structures and integrate the functions of truss structure element, actively controlled actuator, and sensor. The active members must control structural motion to the sub-micron level and, for many proposed space applications, work at cryogenic temperatures. Under this program both room temperature and cryogenic temperature magnetostrictive active members were designed, fabricated, and tested. The results of these performance tests indicated that room temperature magnetostrictive actuators feature higher strain, stiffness, and force capability with lower amplifier requirements than similarly sized piezoelectric or electrostrictive active members, at the cost of higher mass. Two different cryogenic temperature magnetostrictive materials were tested at liquid nitrogen temperatures, both with larger strain capability than the room temperature magnetostrictive materials. The cryogenic active member development included the design and fabrication of a cryostat that allows operation of the cryogenic active member in a space structure testbed.

  7. Getting Acquainted: Thinking about the Soviet Union. Elementary Teaching Activities: Days of Dialogue, 1986.

    ERIC Educational Resources Information Center

    Keys, Charlotte; And Others

    This guide is designed to replace the ignorance, misinformation, and negative stereotypes that many students hold about the Soviet Union and its peoples with a reasoned and rational outlook based on critical thinking and class activities. The introduction to these activities provides background and a rationale for teaching about the Soviet Union.…

  8. Activism in Concrete: Student Union, San Francisco State University

    ERIC Educational Resources Information Center

    Progressive Architecture, 1978

    1978-01-01

    The San Francisco State University Student Union is a futurist design of two steel space-frame pyramids. Each contains a stairway leading to four partial floors that diminish in size as the pyramid tapers. (Author/MLF)

  9. 12 CFR 721.5 - What limitations apply to a credit union engaging in activities approved under this part?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false What limitations apply to a credit union... UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.5 What limitations apply to a credit union engaging in activities approved under this part? You must comply with...

  10. 12 CFR 721.6 - May a credit union derive income from activities approved under this part?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false May a credit union derive income from activities approved under this part? 721.6 Section 721.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.6 May a credit union derive...

  11. 12 CFR 721.5 - What limitations apply to a credit union engaging in activities approved under this part?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false What limitations apply to a credit union... UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.5 What limitations apply to a credit union engaging in activities approved under this part? You must comply with...

  12. 12 CFR 721.5 - What limitations apply to a credit union engaging in activities approved under this part?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What limitations apply to a credit union... UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.5 What limitations apply to a credit union engaging in activities approved under this part? You must comply with...

  13. 12 CFR 721.6 - May a credit union derive income from activities approved under this part?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false May a credit union derive income from activities approved under this part? 721.6 Section 721.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.6 May a credit union derive...

  14. 12 CFR 721.5 - What limitations apply to a credit union engaging in activities approved under this part?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false What limitations apply to a credit union... UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.5 What limitations apply to a credit union engaging in activities approved under this part? You must comply with...

  15. 12 CFR 721.6 - May a credit union derive income from activities approved under this part?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false May a credit union derive income from activities approved under this part? 721.6 Section 721.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.6 May a credit union derive...

  16. 12 CFR 721.6 - May a credit union derive income from activities approved under this part?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false May a credit union derive income from activities approved under this part? 721.6 Section 721.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.6 May a credit union derive...

  17. 12 CFR 721.6 - May a credit union derive income from activities approved under this part?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false May a credit union derive income from activities approved under this part? 721.6 Section 721.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.6 May a credit union derive...

  18. 12 CFR 721.5 - What limitations apply to a credit union engaging in activities approved under this part?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false What limitations apply to a credit union... UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.5 What limitations apply to a credit union engaging in activities approved under this part? You must comply with...

  19. Selection of active member locations in adaptive structures

    NASA Technical Reports Server (NTRS)

    Chen, G.-S.; Bruno, R.; Salama, M.

    1989-01-01

    The effective use of multiple passive and active members in adaptive structures necessitates that these members be optimally distributed throughout the structure. In truss structures, the problem falls into the class of combinatorial optimization for which the solution becomes exceedingly intractable as the problem size increases. This is overcome by using the simulated annealing algorithm to obtain near optimal locations for passive and/or active members. The maximization of the rate of energy dissipation over a finite time period as the measure of optimality is adopted. The selection of optimal locations for both passive and active members is consistently treated through the use of the energy dissipation rate criterion within the simulated annealing algorithm. Numerical examples are used to illustrate the effectiveness of the methodology for large truss structures.

  20. Technology in College Unions and Student Activities: A Collection of Technology Resources from the ACUI Community

    ERIC Educational Resources Information Center

    Association of College Unions International (NJ1), 2012

    2012-01-01

    This publication presents a collection of technology resources from the Association of College Unions International (ACUI) community. Contents include: (1) Podcasting (Jeff Lail); (2) Video Podcasting (Ed Cabellon); (3) Building a Multimedia Production Center (Nathan Byrer); (4) Cloud Computing in the Student Union and Student Activities (TJ…

  1. The Role of Mentoring in the Identification and Selection of College Student Unions/Activities Careers

    ERIC Educational Resources Information Center

    McIntosh, Kathleen K.

    2011-01-01

    Commonly referred to as the living room of campuses, student union facilities serve as an environment for the social, cognitive, cultural, and intellectual education of students that occurs outside the classroom. This study aims to provide an understanding and knowledge of the student union-activities profession, its dedicated professionals, and…

  2. 20 CFR 632.122 - Unionization and antiunionization activities; work stoppages.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...; work stoppages. 632.122 Section 632.122 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Program Abuse § 632.122 Unionization and antiunionization activities; work stoppages. (a) No funds under the Act shall be used in any way to either promote or oppose unionization (sec. 143(c)(1)). (b)...

  3. 20 CFR 641.839 - What policies govern union organizing activities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false What policies govern union organizing... LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Administrative Requirements § 641.839 What policies govern union organizing activities? Recipients must ensure that SCSEP funds...

  4. 20 CFR 641.839 - What policies govern union organizing activities?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false What policies govern union organizing... LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Administrative Requirements § 641.839 What policies govern union organizing activities? Recipients must ensure that SCSEP funds...

  5. 20 CFR 641.839 - What policies govern union organizing activities?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false What policies govern union organizing... LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Administrative Requirements § 641.839 What policies govern union organizing activities? Recipients must ensure that SCSEP funds...

  6. 20 CFR 641.839 - What policies govern union organizing activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What policies govern union organizing... LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Administrative Requirements § 641.839 What policies govern union organizing activities? Recipients must ensure that SCSEP funds...

  7. Theoretical and experimental studies of a truss incorporating active members

    NASA Astrophysics Data System (ADS)

    Edberg, D. L.; Bicos, A. S.; Fuller, C. M.; Tracy, J. J.; Fechter, J. S.

    1992-04-01

    To model the behavior of the piezoelectric elements, a unique finite-element formulation of the piezoelectric struts has been developed which is based on the MSC/NASTRAN CQUAD4 element. The formulation uses the element's Poisson expansion under in-plane loading to make its behavior simulate a piezoelectric member. It is shown that the active members in the MDSSC CSI truss are useful in the investigation of a variety of vibration dissipitation and damage detection techniques.

  8. Project on Citizen Education in a Union Setting, Final Report.

    ERIC Educational Resources Information Center

    University and College Labor Education Association, East Lansing, MI.

    The report describes a project on union citizenship activity and presents recommendations from a labor education conference in Silver Spring, Maryland, November 9-10, 1977. Citizen education of union members involves training programs for workers undertaken either singly by unions or in concert with educational institutions. The report is…

  9. Independent and joint effects of personality on intentions to become an active participant in local union activities in Canada.

    PubMed

    McPhee, Deborah M; Sears, Greg J; Wiesner, Willi H

    2014-01-01

    Drawing on the theory of planned behavior (TPB), this field study (N = 282) investigates the impact of two focal personality traits, extraversion and conscientiousness, on employees' attitudes and intentions to actively participate in their local union. Consistent with the TPB, subjective norms, perceived behavioral control, and attitudes toward participation each explained unique variance in union participation intentions. Furthermore, results revealed that extraversion was positively related, and conscientiousness was negatively related to participation intentions, with attitudes toward participation mediating these effects. A significant interaction between extraversion and conscientiousness was also observed, such that introverted workers higher in conscientiousness were less inclined to express positive attitudes toward union participation. Overall, these results provide support for the utility of the TPB in predicting union participation intentions and highlight the vital role that personality traits may play in determining union participation attitudes and intentions. PMID:24684076

  10. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission regulation... governors of a self-regulatory organization. (3) Committee member means a member, or functional...

  11. Experimental evaluation of active-member control of precision structures

    NASA Technical Reports Server (NTRS)

    Fanson, James; Blackwood, Gary; Chu, Cheng-Chih

    1989-01-01

    The results of closed loop experiments that use piezoelectric active-members to control the flexible motion of a precision truss structure are described. These experiments are directed toward the development of high-performance structural systems as part of the Control/Structure Interaction (CSI) program at JPL. The focus of CSI activity at JPL is to develop the technology necessary to accurately control both the shape and vibration levels in the precision structures from which proposed large space-based observatories will be built. Structural error budgets for these types of structures will likely be in the sub-micron regime; optical tolerances will be even tighter. In order to achieve system level stability and local positioning at this level, it is generally expected that some form of active control will be required.

  12. STS-110 crew members during TCDT slidewire basket activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- -- STS-110 crew members sit in the slidewire basket, part of emergency egress equipment on the pad. From left are Mission Specialists Steven L. Smith, Lee M.E. Morin and Jerry L. Ross. The crew is taking part in Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown, held at KSC prior to each Space Shuttle flight. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  13. Structural control by the use of piezoelectric active members

    NASA Technical Reports Server (NTRS)

    Fanson, J. L.; Chen, J.-C.

    1987-01-01

    Large Space Structures (LSS) exhibit characteristics which make the LSS control problem different form other control problems. LSS will most likely exhibit low frequency, densely spaced and lightly damped modes. In theory, the number of these modes is infinite. Because these structures are flexible, Vibration Suppression (VS) is an important aspect of LSS operation. In terms of VS, the control actuators should be as low mass as possible, have infinite bandwidth, and be electrically powered. It is proposed that actuators be built into the structure as dual purpose structural elements. A piezoelectric active member is proposed for the control of LSS. Such a device would consist of a piezoelectric actuator and sensor for measuring strain, and screwjack actuator in series for use in quasi-static shape control. An experiment simulates an active member using piezoelectric ceramic thin sheet material on a thin, uniform cantilever beam. The feasibility of using the piezoelectric materials for VS on LSS was demonstrated. Positive positive feedback as a VS control strategy was implemented. Multi-mode VS was achieved with dramatic reduction in dynamic response.

  14. Is the European (Active) Citizenship Ideal Fostering Inclusion within the Union? A Critical Review

    ERIC Educational Resources Information Center

    Milana, Marcella

    2008-01-01

    This article reviews: (1) the establishment and functioning of EU citizenship: (2) the resulting perception of education for European active citizenship; and (3) the question of its adequacy for enhancing democratic values and practices within the Union. Key policy documents produced by the EU help to unfold the basic assumptions on which…

  15. Organized Agents: Canadian Teacher Unions as Alternative Sites for Social Justice Activism

    ERIC Educational Resources Information Center

    Rottmann, Cindy

    2008-01-01

    Historically teachers' federations have been some of the major organizational sites for social justice leadership in K-12 public education. Despite this history of activism, social justice teacher unionism remains a relatively underdeveloped concept. This article merges four philosophical conceptions of social justice in education: liberal…

  16. 20 CFR 632.122 - Unionization and antiunionization activities; work stoppages.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...; work stoppages. 632.122 Section 632.122 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Program Abuse § 632.122 Unionization and antiunionization activities; work stoppages. (a) No funds under... position which is affected by labor disputes involving a work stoppage. If such a work stoppage...

  17. 20 CFR 641.839 - What policies govern union organizing activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What policies govern union organizing activities? 641.839 Section 641.839 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING THE SENIOR COMMUNITY SERVICE EMPLOYMENT PROGRAM Administrative...

  18. The Evolution of Legislation in the Field of Medically Assisted Reproduction and Embryo Stem Cell Research in European Union Members

    PubMed Central

    Busardò, Francesco Paolo; Napoletano, Simona; Zaami, Simona; Frati, Paola

    2014-01-01

    Medically Assisted Reproduction (MAR), involving in vitro fertilisation (IVF), and research on embryos have created expectation to many people affected by infertility; at the same time it has generated a surplus of laws and ethical and social debates. Undoubtedly, MAR represents a rather new medical field and constant developments in medicine and new opportunities continue to defy the attempt to respond to those questions. In this paper, the authors reviewed the current legislation in the 28 EU member states trying to evaluate the different legislation paths adopted over the last 15 years and highlighting those EU countries with no specific legislation in place and MAR is covered by a general health Law and those countries in which there are no laws in this field but only “guidelines.” The second aim of this work has been to compare MAR legislation and embryo research in EU countries, which derive from different origins ranging from an extremely prohibitive approach versus a liberal one, going through a cautious regulatory approach. PMID:25147794

  19. The World Informatics Scene: ICSU, International Unions and Associations, Professional Society Activities

    NASA Astrophysics Data System (ADS)

    Fox, P.; Barton, C.

    2009-04-01

    Now that the Electronic Geophysical Year (2007-2008) has concluded, a substantial number of new coordination efforts under the heading of informatics have emerged. These efforts range from divisions/ sections in societies such as the Geological Society of America, the American Geophysical Union and the European Geosciences Union devoted to all aspects of informatics. In each case there has been a strong community response at their regular meetings. These society efforts are closer to the working scientists, technologists and data producers, and managers. At the same time, in a recognition for the need of a sustained activity such as eGY, the International Union of Geodesy and Geophysics (IUGG) has formed a Union Commission for Data and Information and the Committee on Data for Science and Technology (CODATA) approved a Task Group on eGY Earth and Space Science Data Interoperability. The International Council of Science's (ICSU) Strategic Committee on Information and Data (SCID) implementation report was approved by the ICSU general assembly in October 2008. ICSU's priority area assessment strategy for ICSU to play a leadership role in the coordination of data and information efforts world-wide. This report is being implemented and influences entities such as CODATA, and forms a new World Data System. This presentation will give details on the abovementioned activities and indicate an emerging synergy for Informatics across many discipline and the advancement of science and societal goals.

  20. 12 CFR 721.4 - How may a credit union apply to engage in an activity that is not preapproved as within a credit...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false How may a credit union apply to engage in an activity that is not preapproved as within a credit union's incidental powers? 721.4 Section 721.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL...

  1. 12 CFR 721.4 - How may a credit union apply to engage in an activity that is not preapproved as within a credit...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false How may a credit union apply to engage in an activity that is not preapproved as within a credit union's incidental powers? 721.4 Section 721.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL...

  2. 12 CFR 721.4 - How may a credit union apply to engage in an activity that is not preapproved as within a credit...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false How may a credit union apply to engage in an activity that is not preapproved as within a credit union's incidental powers? 721.4 Section 721.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL...

  3. Perspective on OECD activities from a non-member country.

    PubMed

    Alexandrova, Nevena; Atanassov, Atanas

    2006-01-01

    The OECD Blue Book, "Recombinant DNA: Safety Considerations" was published in 1986. The developed principles and concepts on the stepwise and case-by-case approach for risk assessment in the Blue Book have been used as a foundation for building national biosafety frameworks and international instruments for the regulation of the products of modern biotechnology. Twenty years after the Blue Book was published, OECD continues its activities on unique identifier systems, information-sharing, consensus documents for the biology of crops, trees and microorganisms with respect to harmonization of regulatory oversight and those of novel food and feed safety. These activities benefit, without any doubt, the international community at large, including OECD non-member countries. In order to strengthen its position in the international arena and to better respond to the needs of the changing world, OECD would be encouraged to participate in a more active manner in the technology transfer process and co-existence debate, together with continuing the organization's efforts on information-sharing and harmonization in the field of biotechnology and biosafety. PMID:17640514

  4. The World Informatics Scene: ICSU, International Unions and Associations, Professional Society Activities

    NASA Astrophysics Data System (ADS)

    Fox, Peter

    In the lead up to, and during, the Electronic Geophysical Year (2007-2008), a substantial number of new coordinated efforts under the heading of informatics (defined as: ) have emerged. These efforts range from the formation of divisions/ sections in societies such as the Geological Society of America, the American Geophysical Union and the European Geosciences Union devoted to all aspects of informatics and have seen strong community response at their regular meetings. These society efforts are closer to the working scientists, technologists and data producers, and managers. At the same time, in a recognition for the need of a sustained activity such as eGY, two ad-hoc committees produced proposals for a) the formation of a Union Commission for Data and Information within the International Union of Geodesy and Geophysics (IUGG) and b) the Committee on Data for Science and Technology (CODATA) approved a Working Group on XX, with the intent that it will become a Task Group after the 2008 CODATA general assembly. The International Council of Science's (ICSU) Strategic Committee on Information and Data (SCID) will deliver its report on implementation ICSU's priority area assessment strategy for ICSU to play a leadership role in the coordination of data and information efforts world-wide. This report will influence entities such as CODATA, the World Data Centres, the Federation of Astrophysical and Geophysical Data Services (FAGS) and, most likely, all ICSU Unions. This presentation will give details on the abovementioned activities and indicate an emerging synergy for Informatics across many discipline and the advancement of science and societal goals. The presentation will also include suggestions for the COSPAR community to engage in on-going activities.

  5. Maps showing coal-split boundaries, isopachs of coal splits, coal resources, and coal quality; Mammoth coal bed, Paleocene Tongue River Member of the Fort Union Formation, Bull Mountain coal field, south-central Montana

    SciTech Connect

    Connor, C.W.

    1989-01-01

    A U.S. Geological Survey Maps are presented showing coal-split boundaries, isopachs of coal splits, coal resources, and coal quality; mammoth coal bed, Paleocene Tongue River Member of the Fort Union Formation, Bull Mountain coal field, south-central Montana.

  6. 12 CFR 721.4 - How may a credit union apply to engage in an activity that is not preapproved as within a credit...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false How may a credit union apply to engage in an activity that is not preapproved as within a credit union's incidental powers? 721.4 Section 721.4 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INCIDENTAL POWERS § 721.4 How may a credit union apply...

  7. Compulsory Unionism and the Demise of Education.

    ERIC Educational Resources Information Center

    Staub, Susan E.

    1981-01-01

    Argues that forced unionism for teachers and forced union fees are undemocratic. Maintains that teacher unions will represent the interests of their members only when they must compete for membership. (Author/WD)

  8. Fraternity Hazing Revisited: Current Alumni and Active Member Attitudes Toward Hazing.

    ERIC Educational Resources Information Center

    Baier, John L.; Williams, Patrick S.

    1983-01-01

    Studied hazing practices at a large university and compared active and alumni fraternity members' (N=259) attitudes towards them. Results showed alumni accepted hazing more than active members. Most members believed hazing served a valuable purpose and did not create problems in their own chapter. (WAS)

  9. A pilot validation in 10 European Union Member States of a point prevalence survey of healthcare-associated infections and antimicrobial use in acute hospitals in Europe, 2011.

    PubMed

    Reilly, J S; Price, L; Godwin, J; Cairns, S; Hopkins, S; Cookson, B; Malcolm, W; Hughes, G; Lyytikainen, O; Coignard, B; Hansen, S; Suetens, C

    2015-01-01

    We present a pilot validation study performed on 10 European Union (EU) Member States, of a point prevalence survey (PPS) of healthcare-associated infections (HAIs) and antimicrobial use in Europe in 2011 involving 29 EU/European Economic Area (EEA) countries and Croatia. A total of 20 acute hospitals and 1,950 patient records were included in the pilot study, which consisted of validation and inter-rater reliability (IRR) testing using an in-hospital observation approach. In the validation, a sensitivity of 83% (95% confidence interval (CI): 79–87%) and a specificity of 98% (95% CI: 98–99%) were found for HAIs. The level of agreement between the primary PPS and validation results were very good for HAIs overall (Cohen’s κappa (κ):0.81) and across all the types of HAIs (range: 0.83 for bloodstream infections to 1.00 for lower respiratory tract infections). Antimicrobial use had a sensitivity of 94% (95% CI: 93–95%) and specificity of 97% (95% CI: 96–98%) with a very good level of agreement (κ:0.91). Agreement on other demographic items ranged from moderate to very good (κ: 0.57–0.95): age (κ:0.95), sex (κ: 0.93), specialty of physician (κ: 0.87) and McCabe score (κ: 0.57). IRR showed a very good level of agreement (κ: 0.92) for both the presence of HAIs and antimicrobial use. This pilot study suggested valid and reliable reporting of HAIs and antimicrobial use in the PPS dataset. The lower level of sensitivity with respect to reporting of HAIs reinforces the importance of training data collectors and including validation studies as part of a PPS in order for the burden of HAIs to be better estimated. PMID:25742434

  10. Provenance of the Tullock member of the Fort Union formation, Powder River Basin, Wyoming and Montana: Evidence for early Paleocene Laramide uplift

    SciTech Connect

    Hansley, P.L.; Brown, J.L. )

    1993-01-01

    A petrologic and provenance study of the lower Paleocene Tullock Member of the Fort Union Formation in the Powder River Basin (PRB) indicates that Laramide uplifts to the west and south of the PRB were emergent and shedding detritus by early Paleocene time. This conclusion is based largely on the presence of abundant first-cycle carbonate clasts in the northwestern PRB and metamorphic and igneous clasts and labile heavy-mineral grains in the Tullock throughout the basin. The proximity and composition of the north end of the Bighorn uplift strongly suggest that is was the source for carbonate, igneous, and metamorphic rock fragments in northwestern Tullock outcrops. Lack of conglomeratic material in northwestern outcrops, however, indicates that the Bighorn uplift was not yet well developed and perhaps the Pryor Mountains uplift farther to the west was contributing some detritus. In the southern PRB, abundant labile heavy minerals and igneous rock fragments in the Tullock indicate that other uplifts to the west and south (i.e. Granite Mountains, Washakie, Owl Creek, and Laramie uplifts) had also started to rise by early Paleocene time. Paleocurrent directions show that Tullock streams flowed generally east-northeast across a gently sloping alluvial plain toward the retreating Cannonball sea, suggesting that the Black Hills were not yet emergent and, as a result, the basin had not fully developed. Our conclusions are supported by recent fission-track, palynological, and sedimentological studies that indicate that Laramide-style forland deformation in southwestern Montana began in late Cenomanian to Turonian time and migrated through central Wyoming to the Colorado Front Range by late Maastrichtian time. 37 refs., 8 figs., 3 tab.

  11. Spinal muscle activity in simulated rugby union scrummaging is affected by different engagement conditions.

    PubMed

    Cazzola, D; Stone, B; Holsgrove, T P; Trewartha, G; Preatoni, E

    2016-04-01

    Biomechanical studies of rugby union scrummaging have focused on kinetic and kinematic analyses, while muscle activation strategies employed by front-row players during scrummaging are still unknown. The aim of the current study was to investigate the activity of spinal muscles during machine and live scrums. Nine male front-row forwards scrummaged as individuals against a scrum machine under "crouch-touch-set" and "crouch-bind-set" conditions, and against a two-player opposition in a simulated live condition. Muscle activities of the sternocleidomastoid, upper trapezius, and erector spinae were measured over the pre-engagement, engagement, and sustained-push phases. The "crouch-bind-set" condition increased muscle activity of the upper trapezius and sternocleidomastoid before and during the engagement phase in machine scrummaging. During the sustained-push phase, live scrummaging generated higher activities of the erector spinae than either machine conditions. These results suggest that the pre-bind, prior to engagement, may effectively prepare the cervical spine by stiffening joints before the impact phase. Additionally, machine scrummaging does not replicate the muscular demands of live scrummaging for the erector spinae, and for this reason, we advise rugby union forwards to ensure scrummaging is practiced in live situations to improve the specificity of their neuromuscular activation strategies in relation to resisting external loads. PMID:25818526

  12. Magnetostratigraphy and Magnetic Mineralogy of the Ludlow Member of the Fort Union Formation (Lower Paleocene) of the Williston Basin in North Dakota

    NASA Astrophysics Data System (ADS)

    Peppe, D. J.; Evans, D. A.

    2006-12-01

    A continuous succession of Cretaceous through lowermost Eocene terrestrial sediments contains a nearly complete Paleocene record, in the Little Missouri River Valley of North Dakota, USA. We aim to calibrate the rates of post-Cretaceous ecological recovery from mass extinction, by determining a detailed chronostratigraphy of plant and mammal fossils in the basin. Using the Cretaceous-Paleogene (K-T) boundary as the basal datum, we have constructed a ca.300 meter composite section of the Upper Cretaceous Hell Creek Formation and the Lower Paleocene Ludlow Member of the Fort Union Formation. We analyzed paleomagnetic samples from 12 stratigraphic sections using a combined low-AF and thermal demagnetization strategy. Instability of magnetization above 200 °C has been reported in previous studies, which we reproduced when heating in air; however, when the samples were heated in nitrogen the stability field extended to well above 300 °C. The analyzed samples demonstrate a series of geomagnetic reversals that can be correlated from C29n through C27r of the Geomagnetic Polarity Time Scale (GPTS). Bulk susceptibility vs. temperature studies on sandstone, siltstone, and carbonaceous shale indicate predominately irreversible curves suggesting titanomaghemite as the magnetic carrier in the Ludlow Member sediments. IRM acquisition in our samples consistently shows non-saturation above 100 mT indicating an additional anti-ferromagnetic component, most likely goethite. The dominant iron oxide in these samples, titanomaghemite, was generated either during weathering of the source terrain during Laramide uplift, or weathered in-situ prior to diagenesis, or during alteration after burial. We infer that the magnetization of the samples is primary because the polarity direction is consistent with that of the Paleocene of North America and the reversal stratigraphy from this section corresponds to the GPTS with reasonable sedimentation rates. Our results imply a temporal restriction

  13. Training for Transition: A Union View.

    ERIC Educational Resources Information Center

    Gotbaum, Victor

    1979-01-01

    A representative of a New York public service union discusses the role of his union in the education of workers. Focus is on the union's provisions for the educational needs of members, and changes in the workplace, particularly the trend away from industrial jobs to service occupations, for which union members must be prepared. (JMD)

  14. Power in a Union

    ERIC Educational Resources Information Center

    Johnson, Pam

    2009-01-01

    The work unions do in providing and supporting learning for their members rarely makes the news headlines, but it will be essential if people are to engage those workers who most need to acquire new and better skills to cope in the economic downturn. In this article, the author talks about the power in a union and describes UNISON, a comparatively…

  15. 77 FR 27542 - Agency Information Collection Activities (Bereaved Family Member Satisfaction Survey) Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... AFFAIRS Agency Information Collection Activities (Bereaved Family Member Satisfaction Survey) Under OMB... INFORMATION: Title: Bereaved Family Member Satisfaction Survey, VA Form 10- 21081(NR). OMB Control Number... VA Form 10-21081(NR) will be use to survey family members of deceased veterans on their...

  16. Unionism in the health care industry: an overview.

    PubMed

    Block, R

    1979-08-01

    Block profiles the two unions that are the most active in organizing non-nurse health care employees: the National Hospital Union (NHU) and the Service Employees International Union (SEIU). The two international unions present a contrast in structure and ideology. The SEIU is a truly international, decentralized union, whereas NHU is a far more centralized affiliate. As an international union, SEIU characterizes, taxes, and disciplines locals. Its decentralized strategy has been to permit locals to do the bulk of the organizing and collective bargaining, while the national union merely coordinates and offers financial and technical support. Conversely, NHU is an affiliate of the retail, wholesale, and department store union, deriving authority from, paying tax to, and subject to discipline by the parent organization. Its centralized approach has been for national officers to determine when a district will be created and what its jurisdiction will be. The structural differences of the two unions can be traced to their respective histories. As an old-line AFL union, SEIU had an existing structure of independent local unions that operated in health care as they did in other industries. NHU, however, originated as a union of drug store employees and its structure evolved over time. Membership growth and geographic expansion elevated it beyond the status of a local into a division with its own districts. The unions also diverge in their ideology; SEIU takes a more traditional business union approach to collective bargaining and unionism, while NHU is oriented to social welfare, involving itself in more than the work aspect of members' lives. These differences again can be attributed to contrasting histories of the old-line SEIU and the more radical NHU. The authors emphasize that unions are not homogeneous entities but organizations that respond to a similar environment as a result of their respective structures and histories. PMID:10248094

  17. Development of an active member using piezoelectric and electrostrictive actuation for control of precision structures

    NASA Technical Reports Server (NTRS)

    Anderson, E. H.; Moore, D. M.; Fanson, J. L.; Ealey, M. A.

    1990-01-01

    The design and development of a zero stiction active member containing piezoelectric and electrostrictive actuator motors is presented. The active member is intended for use in submicron control of structures. Experimental results are shown which illustrate actuator and device characteristics relevant to precision control applications.

  18. On the placement of active members in adaptive truss structures for vibration control

    NASA Technical Reports Server (NTRS)

    Lu, L.-Y.; Utku, S.; Wada, B. K.

    1992-01-01

    The problem of optimal placement of active members which are used for vibration control in adaptive truss structures is investigated. The control scheme is based on the method of eigenvalue assignment as a means of shaping the transient response of the controlled adaptive structures, and the minimization of required control action is considered as the optimization criterion. To this end, a performance index which measures the control strokes of active members is formulated in an efficient way. In order to reduce the computation burden, particularly for the case where the locations of active members have to be selected from a large set of available sites, several heuristic searching schemes are proposed for obtaining the near-optimal locations. The proposed schemes significantly reduce the computational complexity of placing multiple active members to the order of that when a single active member is placed.

  19. Recent activities of EC4 in the harmonization of clinical chemistry in the European Union.

    PubMed

    Sanders, G T; Jansen, R T; Beastall, G; Gurr, E; Kenny, D; Kohse, K P; Zérah, S

    1999-04-01

    This article describes the recent activities of the European Communities Confederation of Clinical Chemistry (EC4). Main goal of EC4 is harmonization of clinical chemistry in the European Union and Europe. EC4's actions connected to that are training and registration of professionals, and accreditation of laboratories. The 35000 professionals practising clinical chemistry in the EU have different backgrounds (medical, pharmaceutical, science-oriented, veterinary, or microbiological). Thus, for the harmonization of training of clinical chemists, EC4 has published a European Syllabus for Postgraduate Training, and instituted a European Union Register for Clinical Chemists. The Syllabus is an indication of the level of requirements in postgraduate training. The EC4 initiative to implement the European Register for Clinical Chemists is based on the 8 years vocational training necessary to obtain sufficient knowledge in clinical chemistry according to the European Syllabus. A guide to the EC4 Register has been published; registration leads to the title European Clinical Chemist (EurClinChem). The accreditation of laboratories must be based on a total quality management system. EC4 has described guidelines (essential criteria) which it judges appropriate for establishing the quality of medical laboratory service; it does not wish to fulfil the role of an accrediting body. Moreover, a working group has been set up to seek to harmonize the work of national accrediting bodies. Therefore, it is logical that EC4 monitors the activities of the different standardizing bodies that might influence the practice of clinical chemistry in the EU. Finally, some aspects concerning the future strategy of EC4 are brought forward. PMID:10369121

  20. Space activities and radiation protection of crew members

    NASA Astrophysics Data System (ADS)

    Straube, Ulrich; Berger, Thomas; Reitz, Guenther; Facius, Rainer; Reiter, Thomas; Kehl, Marcel; Damann, M. D. Volker; Tognini, Michel

    Personnel working as crew in space-based activities e.g. professional astronauts and cosmo-nauts but also -to a certain extend-space flight participants ("space tourists"), demand health and safety considerations that have to include radiation protection measures. The radiation environment that a crew is exposed to during a space flight, differs significantly to that found on earth including commercial aviation, mainly due to the presence of heavy charged particles with great potential for biological damage. The exposure exceeds those routinely received by terrestrial radiation workers. A sequence of activities has to be conducted targeting to mitigate adverse effects of space radiation. Considerable information is available and applied through the joint efforts of the Space Agencies that are involved in the operations of the International Space Station, ISS. This presentation will give an introduction to the current measures for ra-diation monitoring and protection of astronauts of the European Space Agency (ESA). It will include information: on the radiation protection guidelines that shall ensure the proper imple-mentation and execution of radiation protection measures, the operational hardware used for radiation monitoring and personal dosimetry on ISS, as well as information about operational procedures that are applied.

  1. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. - As part of Crew Equipment Interface Test activities, STS-113 Mission Specialists Michael Lopez-Alegria (left) and John Herrington (center) look over equipment that will be carried on the mission. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  2. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- As part of Crew Equipment Interface Test activities, STS-113 Mission Specialists John Herrington (left) and Michael Lopez-Alegria (center) practice working with equipment in Endeavour. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  3. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- As part of Crew Equipment Interface Test activities, STS-113 Mission Specialists Michael Lopez-Alegria (left) and John Herrington (right) practice working with flight equipment in Endeavour. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  4. STS-113 crew members take part in CEIT activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- As part of Crew Equipment Interface Test activities, STS-113 Mission Specialist John Herrington looks over paperwork for equipment in Endeavour that will be carried on the mission. The primary payloads on mission STS-113 are the first port truss segment, P1 Truss, to be attached to the central truss segment, S0, on the International Space Station, and the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. Once delivered, the P1 truss will remain stowed until flight 12A.1. The mission will also deliver the Expedition 6 crew to the Station and return Expedition 5 to Earth. Space Shuttle Endeavour is scheduled to launch Nov. 10 on the 11-day mission.

  5. Communist purges of Soviet Academy of Sciences members and solar activity

    NASA Astrophysics Data System (ADS)

    Tomilin, Konstantin A.

    The author is investigating the corelation between the intansity of Communsit purges under Members of the Academy of Sciences of USSR and Solar Activity, based on previous researches by Alexander Leonidovich Chizhevskij (1897-1964).

  6. Which Members of the Microbial Communities Are Active? Microarrays

    NASA Astrophysics Data System (ADS)

    Morris, Brandon E. L.

    only at the early stages of understanding the microbial processes that occur in petroliferous formations and the surrounding subterranean environment. Important first steps in characterising the microbiology of oilfield systems involve identifying the microbial community structure and determining how population diversity changes are affected by the overall geochemical and biological parameters of the system. This is relatively easy to do today by using general 16S rRNA primers for PCR and building clone libraries. For example, previous studies using molecular methods characterised many dominant prokaryotes in petroleum reservoirs (Orphan et al., 2000) and in two Alaskan North Slope oil facilities (Duncan et al., 2009; Pham et al., 2009). However, the problem is that more traditional molecular biology approaches, such as 16S clone libraries, fail to detect large portions of the community perhaps missing up to half of the biodiversity (see Hong et al., 2009) and require significant laboratory time to construct large libraries necessary to increase the probability of detecting the majority of even bacterial biodiversity. In the energy sector, the overarching desire would be to quickly assess the extent of in situ hydrocarbon biodegradation or to disrupt detrimental processes such as biofouling, and in these cases it may not be necessary to identify specific microbial species. Rather, it would be more critical to evaluate metabolic processes or monitor gene products that are implicated in the specific activity of interest. Research goals such as these are well suited for a tailored application of microarray technology.

  7. 12 CFR 701.21 - Loans to members and lines of credit to members.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Loans to members and lines of credit to members. 701.21 Section 701.21 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.21 Loans to members and lines of credit to members. (a) Statement of...

  8. Agency Shop Fees and the Supreme Court: Union Control and Academic Freedom.

    ERIC Educational Resources Information Center

    Russo, Charles J.; And Others

    1992-01-01

    In "Lehnert v. Ferris Faculty Association" the Supreme Court agreed that local unions can charge nonmembers for some parent-organization expenses not directly related to bargaining. Contends that the decision weakens the academic freedom for college and university faculty members who do not wish to voluntarily support union activity. (21…

  9. An analysis of risk domains associated with drug transitions of active Latino gang members.

    PubMed

    De La Rosa, Mario; Rugh, Douglas; Rice, Christopher

    2006-01-01

    Alcohol and illicit drug abuse is a serious problem among male Latino gang members. Research indicates that gang members increase their drug use while they are members, and use more drugs after they leave the gangs. This manuscript reports on data reflecting the influences of individual, familial, peer, and community factors on the number of drug use transitions that Latino gang members undergo during their drug using careers. Data from this study were collected from interviews conducted with seventy-six active Latino gang members. The study's results indicate that age at the time of interview and lower age of drug onset were associated with a greater number of drug use transitions. Positive family attitudes toward deviance, friend drug use, school truancy, conflict with parents, and living in neighborhoods with a high level of crime were also found to be associated with increased drug use transitions. PMID:17088228

  10. Space activities in the Soviet Union, Japan, and the People's Republic of China

    NASA Technical Reports Server (NTRS)

    Ezell, E. C.

    1985-01-01

    The space programs of the Soviet Union, Japan, and China are discussed. The types of launch vehicles they used and the classes of spacecraft they launched are examined. The political motivations of these nations are analyzed.

  11. Match-play activity profile in elite women's rugby union players.

    PubMed

    Suarez-Arrones, Luis; Portillo, Javier; Pareja-Blanco, Fernando; Sáez de Villareal, Eduardo; Sánchez-Medina, Luis; Munguía-Izquierdo, Diego

    2014-02-01

    The aim of this study was to provide an objective description of the locomotive activities and exercise intensity undergone during the course of an international-level match of female rugby union. Eight players were analyzed using global positioning system tracking technology. The total distance covered by the players during the whole match was 5,820 ± 512 m. The backs covered significantly more distance than the forwards (6,356 ± 144 vs. 5,498 ± 412 m, respectively). Over this distance, 42.7% (2,487 ± 391 m) was spent standing or walking, 35% jogging (2,037 ± 315 m), 9.7% running at low intensity (566 ± 115 m), 9.5% at medium intensity (553 ± 190 m), 1.8% at high intensity (105 ± 74 m), and 1.2% sprinting (73 ± 107 m). There were significant differences in the distance covered by forwards and backs in certain speed zones. Analysis of the relative distance traveled over successive 10-minute period of match play revealed that the greatest distances were covered during the first (725 ± 53 m) and the last (702 ± 79 m) 10-minute period of the match. The average number of sprints, the average maximum distance of sprinting, the average minimum distance of sprinting, and the average sprint distance during the game were 4.7 ± 3.9 sprints, 20.6 ± 10.5 m, 5.8 ± 0.9 -m, and 12.0 ± 3.8 m, respectively. There were substantial differences between forwards and backs. Backs covered greater total distance, distance in certain speed zones, and sprinting performance. The players spent 46.9 ± 28.9% of match time between 91 and 100% of maximum heart rate and experienced a large number of impacts (accelerometer data and expressed as g forces) during the game. These findings offer important information to design better training strategies and physical fitness testing adapted to the specific demands of female rugby union. PMID:23698080

  12. Informal Food Production in the Enlarged European Union

    ERIC Educational Resources Information Center

    Alber, Jens; Kohler, Ulrich

    2008-01-01

    How widespread is the production of food in old and new member states of the European Union and what is the social meaning or logic of such activities? We show that growing food is (a) more widespread in former communist countries than in traditional market economies and (b) is predominantly a hobby or recreational activity in affluent countries,…

  13. PLANNING AND OPERATING COLLEGE UNION BUILDINGS.

    ERIC Educational Resources Information Center

    BUTTS, PORTER

    THIS MONOGRAPH IS A DISCUSSION OF FOUR ASPECTS OF STUDENT UNIONS. PART ONE DISCUSSES THE NATURE AND PURPOSE OF A UNION AND THE UNION AS A CAMPUS CENTER. PART TWO DEALS WITH THE PLANNING OF UNION BUILDINGS AND GIVES PROCEDURES, PRINCIPLES AND CAUTIONS. UNION FACILITIES AND SERVICES ARE LISTED. PART THREE DISCUSSES THE ORGANIZATION AND ACTIVITIES OF…

  14. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  15. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  16. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  17. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  18. 32 CFR 199.16 - Supplemental Health Care Program for active duty members.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 2 2011-07-01 2011-07-01 false Supplemental Health Care Program for active duty... (CHAMPUS) § 199.16 Supplemental Health Care Program for active duty members. (a) Purpose and applicability. (1) The purpose of this section is to implement, with respect to health care services provided...

  19. What Do Unions Do for Women? Research-in-Brief.

    ERIC Educational Resources Information Center

    Braunstein, Jill; And Others

    Although union membership has been declining overall, the number of women union members continues to increase. Currently, 37 percent of union membership are women. The proportion of women workers who are union members increased from 16.3 percent in 1965 to 19.3 percent in 1975 and fell to 14 percent in 1990; 7.4 million women were represented by…

  20. It's Academic: Public Policy Activities Among Faculty Members in a Department of Medicine

    PubMed Central

    Jacobs, Douglas B.; Greene, Meredith; Bindman, Andrew B.

    2014-01-01

    Problem To investigate whether and how faculty members in a Department of Medicine are engaged in public policy activities. Approach Between February and April 2011 the authors conducted a cross-sectional web-based survey of all active Department of Medicine (DOM) faculty members at the University of California, San Francisco (UCSF). Survey questions covered demographics, academic role, academic rank, and participation in three specific public policy activities during the past five years: (1) policy related research, (2) expert advice to government officials, and (3) public policy advocacy in collaboration with organizations outside government. Outcomes Two hundred twenty of 553 faculty (40%) responded to the survey. One hundred twenty-four faculty members (56% of respondents and 22% of total active faculty) reported that they were engaged in at least one of the three types of policy related activities: 51 (23%) conducted policy related research, 67 (30%) provided expert advice to government officials, and 93 (42%) collaborated with organizations to advocate for public policy. Higher faculty rank was significantly associated with faculty members reporting that they were involved in one or more of the three policy activities (P = .04). Next Steps Academic departments should identify public policy expertise among their faculty and leverage this expertise by facilitating opportunities to develop a shared faculty awareness of their public policy activities, by supporting the establishment of mentoring relationships for less experienced faculty in the area of public policy, and by incorporating standards of excellence for work in public policy into the promotions process. PMID:23969373

  1. Thyroid disorders among active component military members, U.S. Armed Forces, 2002-2011.

    PubMed

    2012-10-01

    During 2002-2011, among active component U.S. military members, the rates of idiopathic hypothyroidism were 39.7 and 7.8 per 10,000 person-years among females and males, respectively. Unadjusted rates of idiopathic hypothyroidism and chronic thyroiditis (e.g., Hashimoto's disease) were at least twice as high among white, non-Hispanic as black, non-Hispanic service members. However, black, non-Hispanic service members had higher rates of goiter and thyrotoxicosis. Increasing rates of thyroid disorders during the period were accompanied by increases in numbers of screening tests for thyroid function recorded during outpatient visits. Increased thyroid function testing since the beginning of the wars in Iraq and Afghanistan may reflect increased testing of military members with mental disorders (e.g., depression, irritability, PTSD), musculoskeletal pain, sleep disorders, menstrual/fertility abnormalities, obesity, and other conditions which have sharply increased in prevalence over the same period. PMID:23121006

  2. Unions: Bread, Butter & Basic Skills.

    ERIC Educational Resources Information Center

    BCEL Newsletter for the Business Community, 1987

    1987-01-01

    Unions are natural providers of basic skills instruction. They are in daily workplace contact with their membership, are trusted to work on members' behalf, and speak the language of the worker. Unions are trying to address the needs of illiterate workers through collective bargaining arrangements in which employers contribute a percentage of…

  3. An Uncharacterized Member of the Ribokinase Family in Thermococcus kodakarensis Exhibits myo-Inositol Kinase Activity*

    PubMed Central

    Sato, Takaaki; Fujihashi, Masahiro; Miyamoto, Yukika; Kuwata, Keiko; Kusaka, Eriko; Fujita, Haruo; Miki, Kunio; Atomi, Haruyuki

    2013-01-01

    Here we performed structural and biochemical analyses on the TK2285 gene product, an uncharacterized protein annotated as a member of the ribokinase family, from the hyperthermophilic archaeon Thermococcus kodakarensis. The three-dimensional structure of the TK2285 protein resembled those of previously characterized members of the ribokinase family including ribokinase, adenosine kinase, and phosphofructokinase. Conserved residues characteristic of this protein family were located in a cleft of the TK2285 protein as in other members whose structures have been determined. We thus examined the kinase activity of the TK2285 protein toward various sugars recognized by well characterized ribokinase family members. Although activity with sugar phosphates and nucleosides was not detected, kinase activity was observed toward d-allose, d-lyxose, d-tagatose, d-talose, d-xylose, and d-xylulose. Kinetic analyses with the six sugar substrates revealed high Km values, suggesting that they were not the true physiological substrates. By examining activity toward amino sugars, sugar alcohols, and disaccharides, we found that the TK2285 protein exhibited prominent kinase activity toward myo-inositol. Kinetic analyses with myo-inositol revealed a greater kcat and much lower Km value than those obtained with the monosaccharides, resulting in over a 2,000-fold increase in kcat/Km values. TK2285 homologs are distributed among members of Thermococcales, and in most species, the gene is positioned close to a myo-inositol monophosphate synthase gene. Our results suggest the presence of a novel subfamily of the ribokinase family whose members are present in Archaea and recognize myo-inositol as a substrate. PMID:23737529

  4. Experiential Team Building for Student Leaders in Union Activities and Residence Halls.

    ERIC Educational Resources Information Center

    Martin, Don; And Others

    This guide offers college or university student union and housing office personnel assistance in developing experiential team building workshops for student leaders. The rationale for providing such training is discussed in terms of the following: (1) resident assistants are usually vital compus leaders, with the potential to be vital student…

  5. 20 CFR 632.122 - Unionization and antiunionization activities; work stoppages.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... participants belong to the labor union involved in the work stoppage, they shall be treated in the same manner..., DEPARTMENT OF LABOR INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Prevention of Fraud and... position which is affected by labor disputes involving a work stoppage. If such a work stoppage...

  6. Growing Worker Activism Pushes Envelope in China: Worker Protests Spread, Despite Repression and "Official Unions."

    ERIC Educational Resources Information Center

    Senser, Robert A.

    2002-01-01

    Asserts that China's rulers are trying to have a free labor market without the freedom, and that the Chinese labor union is actually a branch of the Communist Party. The result is worker exploitation and a burst of worker protests (despite the threat of jail). Describes efforts by Chinese activists to mobilize and empower workers and document…

  7. Risk Factors for Clinically Significant Intimate Partner Violence among Active-Duty Members

    ERIC Educational Resources Information Center

    Smith Slep, Amy M.; Foran, Heather M.; Heyman, Richard E.; Snarr, Jeffery D.

    2011-01-01

    Hypothesized risk factors for men's and women's clinically significant intimate partner violence (CS-IPV) from four ecological levels (i.e., individual, family, workplace, community) were tested in a representative sample of active-duty U.S. Air Force members (N = 42,744). When considered together, we expected only individual and family factors to…

  8. Perceived Environmental Church Support and Physical Activity among Black Church Members

    ERIC Educational Resources Information Center

    Baruth, Meghan; Wilcox, Sara; Saunders, Ruth P.; Hooker, Steven P.; Hussey, James R.; Blair, Steven N.

    2013-01-01

    Background: Churches are an appealing setting for implementing health-related behavior change programs. Purpose: The objective of the study was to examine the relationship between perceived environmental church support for physical activity (PA) and PA behaviors. Method: Black church members from South Carolina ("n" = 309) wore an…

  9. 5 CFR 875.206 - As a new active workforce member, when may I apply?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false As a new active workforce member, when may I apply? 875.206 Section 875.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL LONG TERM CARE INSURANCE PROGRAM Eligibility §...

  10. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  11. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  12. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  13. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What direct service activities may AmeriCorps members perform? 2520.25 Section 2520.25 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  14. 45 CFR 2520.30 - What capacity-building activities may AmeriCorps members perform?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What capacity-building activities may AmeriCorps members perform? 2520.30 Section 2520.30 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS §...

  15. Mutualistic Benefits Generate an Unequal Distribution of Risky Activities Among Unrelated Group Members

    NASA Astrophysics Data System (ADS)

    Kukuk, Penelope F.; Ward, Seamus A.; Jozwiak, Amy

    Recent studies provide a new challenge to the adequacy of theories concerning the evolution of cooperation among nonrelatives: some individuals perform high-risk activities while others do not. We examined a communal hymenopteran species, Lasioglossum(Chilalictus)hemichalceum, to determine why group members engaged in demonstrably risky activities (foraging) tolerate the selfish behavior (remaining in the nest) of unrelated nestmates. Experimental removal of adult females indicated that their presence is required for the protection of brood from ant predators. Nonforagers ensure the continued presence of adults in the nest if the risk-taking foragers die, thereby safeguarding the survival of forager offspring. This results in an unequal distribution of risky activities within social groups in which avoidance of risky activities by some group members is ultimately beneficial to risk takers.

  16. Research Reveals Scale of College Union E-Commerce.

    ERIC Educational Resources Information Center

    Conway, Guy Patrick; Henry, Wilma J.

    2000-01-01

    Reports results of a survey of member schools of the Association of College Unions International concerning extent of e-commerce being conducted on the Web. College Web sites were also evaluated for information on e-commerce activities. A list of institutions currently conducting interactive business and the type of business being conducted is…

  17. Literate Practices in a Modern Credit Union.

    ERIC Educational Resources Information Center

    Keller-Cohen, Deborah

    1987-01-01

    Drawing on research regarding a midwestern credit union, factors characterizing why and how credit unions and their members use credit union documents are discussed in regard to: characteristics of document availability; structure of interactions in which documents are used; attitudes and beliefs about the documents; and functions of documents.…

  18. Women Teachers, Union Affiliation, and the Future of North American Teacher Unionism.

    ERIC Educational Resources Information Center

    Bascia, Nina

    1998-01-01

    Discusses benefits of union affiliation and involvement for women teachers, interpreting data from studies that explored the value of unionism to secondary teachers and researched the work and motives of union-active teachers. Women teachers' motives for union involvement and the gendered nature of their experiences regarding unions offer useful…

  19. The Evolving Role of Union Learning Representatives

    ERIC Educational Resources Information Center

    Moore, Sian; Ross, Cilla

    2008-01-01

    This article suggests that the union learning representative (ULR) is increasingly situated at the heart of trade union activity. The paper draws upon recent research based on interviews with national trade union officers and case studies of union learning activity to explore the competing demands being made upon ULRs and the implications for…

  20. Union Agitators

    ERIC Educational Resources Information Center

    Honawar, Vaishali

    2006-01-01

    A decade has passed since a few union leaders formed the network known as Teacher Union Reform Network (TURN) to search for innovative ways to enhance education. Selling their message has not always been easy. Created in 1995, TURN was the brain child of Adam Urbanski, the president of the Rochester (N.Y.) Teachers Association for the past 25…

  1. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special... credit union. (b) The amount which the Agent member requires each member natural person credit union...

  2. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special... credit union. (b) The amount which the Agent member requires each member natural person credit union...

  3. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special... credit union. (b) The amount which the Agent member requires each member natural person credit union...

  4. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special... credit union. (b) The amount which the Agent member requires each member natural person credit union...

  5. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special... credit union. (b) The amount which the Agent member requires each member natural person credit union...

  6. Workplace justice, citizenship behavior, and turnover intentions in a union context: examining the mediating role of perceived union support and union instrumentality.

    PubMed

    Aryee, S; Chay, Y W

    2001-02-01

    This study examined the relationship between workplace justice afforded by the grievance system and the union outcomes of citizenship behavior and turnover intentions and the mechanisms that underpin these relationships. Respondents (N = 187) were members of a large public sector union in Singapore. Results revealed that perceived union support and union instrumentality fully mediated the relationship between the dimensions of workplace justice and citizenship behavior directed toward the union (OCBO) and citizenship behavior directed at other union members (OCBI). Union instrumentality partially mediated the procedural justice-turnover intentions relationship. PMID:11302227

  7. Sustainable development: a trade union perspective.

    PubMed

    Gereluk, Winston; Royer, Lucien

    2003-01-01

    Sustainable development has become an important issue for trade unions around the world, but progress on sustainable development has been slow. Agenda 21, which came out of the 1992 UN Conference on Environment and Development in Rio de Janeiro, called on workers and trade unions to assume an active role. The International Confederation of Free Trade Unions (ICFTU) and the Trade Union Advisory Committee (TUAC) to the Organization for Economic Co-Operation and Development (OECD) became influential players who represent more than 155 million members in 148 countries and territories. The implementation of Agenda 21 has been hampered by bureaucratic gridlock--a situation that trade unions propose to overcome through innovative strategies on workplaces and workers. They realize that sustainable development cannot take place without radical changes in production and consumption. Globalization is creating opulence on the one hand and grinding poverty on the other. ICFTU and TUAC propose a new "world order" that includes democratic decision-making, popular accountability, transparency, and local control. They have proposed priorities, outlined in this article, for an international approach to sustainable development. PMID:17208715

  8. 24 CFR 960.204 - Denial of admission for criminal activity or drug abuse by household members.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... activity or drug abuse by household members. 960.204 Section 960.204 Housing and Urban Development... HOUSING Admission § 960.204 Denial of admission for criminal activity or drug abuse by household members. (a) Required denial of admission—(1) Persons evicted for drug-related criminal activity. The...

  9. Unions' Deals with Brokers Raise Issues

    ERIC Educational Resources Information Center

    Jacobson, Linda

    2006-01-01

    The New York state attorney general's office is close to announcing a settlement with the 525,000-member New York State United Teachers over a relationship between the union and ING Group, a large financial-services company based in the Netherlands. In that arrangement, the union's Member Benefits division--a separate trust that provides…

  10. The Influence of Teacher Unions in Politics.

    ERIC Educational Resources Information Center

    Berube, Maurice R.

    The National Education Association (NEA, with 1.8 million members) and the American Federation of Teachers (AFT, with 600,000 members) are politically powerful teacher unions attempting to change America's educational politics. With enormous financial and manpower resources, these unions maintain effective lobbying groups seeking favored…

  11. Sunburn among active component service members, U.S. Armed Forces, 2002-2013.

    PubMed

    2014-07-01

    Sunburn is caused by acute overexposure to ultraviolet (UV) radiation directly from the sun or from artificial UV sources. Service members are at risk of excessive exposure to sunlight due to the nature of their military duties, which often involve working and training outdoors, and deployment to environments where UV radiation is more intense. From January 2002 through December 2013, a total of 19,172 incident cases of clinically significant sunburn were diagnosed among active component service members. Most of the cases (80.2%) were first degree sunburn. The incidence rates of sunburn diagnoses were higher among females, white non-Hispanics, younger age groups, individuals in the Marine Corps or Army, and among enlisted service members. Additionally, the rate among recruits was more than 3.5 times the rate for non-recruits. Sixty-one percent of all diagnosed cases occurred from May through July. Sunburn cases occurred in all areas of the U.S., particularly near major recruit and combat training locations. Service members are strongly advised to practice sun safety as a part of heat illness prevention, including properly using broad-spectrum sunscreen, finding or constructing shade during work and rest, wearing protective clothing and military combat eye protection items, and avoiding tanning booths and sun lamps. PMID:25080329

  12. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in § 1.3(ee),...

  13. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission...

  14. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in § 1.3(ee),...

  15. 17 CFR 1.59 - Activities of self-regulatory organization employees, governing board members, committee members...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Activities of self-regulatory... COMMODITY EXCHANGE ACT Miscellaneous § 1.59 Activities of self-regulatory organization employees, governing...) Self-regulatory organization means “self-regulatory organization,” as defined in Commission...

  16. Star wars and strategic defense initiatives: work activity and health symptoms of unionized bank tellers during work reorganization.

    PubMed

    Seifert, A M; Messing, K; Dumais, L

    1997-01-01

    Work activity and health symptoms of bank tellers whose work was undergoing reorganization were examined during a university-union study of the health effects of work in women's traditional jobs. Data were gathered through collective and individual interviews, analysis of work activity, and a questionnaire administered to 305 tellers. Employees worked in a standing posture over 80 percent of the time. More than two-thirds frequently suffered pain in back, legs, and feet. The average teller had been involved in 3.7 robberies as a direct victim and six as a witness. Work required feats of memory and concentration. In order to meet job demands, tellers engaged in supportive activities and teamwork. The introduction of individualized objectives threatened the employees' ability to collaborate and induced distress. More than twice as many tellers as other female workers in Québec experience psychological distress (Ilfeld scale), related to: robbery during the past two years (odds ratio = 1.7; confidence interval = 1.0-2.9); difficult relations with superiors (O.R. = 2.6; C.I. = 1.3-5.3); and full-time work (O.R. = 2.3; C.I. = 1.3-3.9). Diverse methods enriched the analysis, and union participation allowed the proposal of concrete correction measures. PMID:9285277

  17. New Estimates of Private Sector Unionism in the United States.

    ERIC Educational Resources Information Center

    Freeman, Richard B.; Medoff, James L.

    1979-01-01

    The study presents new estimates of two measures of unionism in the United States, the percentage of private sector workers covered by union agreements, and the percentage who are union members. These figures are compared with each other and with previous estimates, showing a decline in private sector unionism. (MF)

  18. Septicemia diagnosed during hospitalizations, active component service members, U.S. Armed Forces, 2000-2012.

    PubMed

    2013-08-01

    During the period 2000 through 2012, the records of 3,360 hospitalized active component service members contained a diagnosis of septicemia. Most of these cases were identified via diagnoses recorded in the first and second diagnostic positions and the numbers and rates of such cases increased dramatically during the period. Rates were higher among women than men and in the oldest and youngest age groups. The most frequent co-occurring diagnoses were pneumonia and infections of the skin and subcutaneous tissue. For the majority of cases of septicemia, no specific etiologic agent was indicated by ICD-9 codes in the record. The most commonly specified agents were Staphylococcus aureus, Escherichia coli, and Streptococcus pneumoniae. Most service members were returned to duty after discharge. The overall mortality associated with hospitalized septicemia cases was 4 percent, but was 5.1 percent for septicemia attributed to gram negative bacteria. Possible reasons why the mortality rate in service members was lower than the rates associated with septicemia in the general population are discussed. PMID:24011371

  19. Analysis of the key active subsites of glycoside hydrolase 13 family members.

    PubMed

    Kumar, Vikash

    2010-05-01

    alpha-Amylase, pullulanase, neopullulanase, cyclomaltodextrinase (CDase), cyclomaltodextin glucanotransferase (CGTase), etc. are some of the amylolytic enzymes that act on polysaccharides. These enzymes differ from each other with respect to substrate and linkage specificities. These enzymes have been grouped into the GH13 (GH, Glycoside Hydrolase) family in the CAZy database on the basis of similarity in amino acid sequence. Members of this family share three domains viz., A, B, and C, which have several binding subsites to accommodate monomeric units of the polysaccharide substrate. Among these subsites, -2, -1, +1, and +2 subsites are the most critical subsites for catalytic activity. In the present study, the substrate analog-, inhibitor-, or product-bound 3-D structures of 24 members of GH13 family have been analyzed to identify the features of the -2, -1, +1, and +2 subsites shared by all the members for recognition of the common substrate. It is found that neither the number nor the nature of the potential hydrogen bond-forming residues is conserved with the exception of the presence of tyrosine as a stacking residue in the -1 subsite. The relative spatial disposition of the conserved subsite residues are conserved as judged by distance matrices. The backbone of the -2, -1, +1, and +2 subsites does not undergo conformational change for the recognition of the substrate. This analysis suggests that these enzymes recognize their substrate on the basis of shape of the substrate rather than on the basis of specific interactions within the binding site. PMID:20227065

  20. 12 CFR 745.13 - Notification to members/shareholders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Notification to members/shareholders. 745.13 Section 745.13 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Notification to members/shareholders. Each insured credit union shall provide notice to its members...

  1. The microstructure of coaching practice: behaviours and activities of an elite rugby union head coach during preparation and competition.

    PubMed

    Hall, Edward Thomas; Gray, Shirley; Sproule, John

    2016-01-01

    The activities and behaviours of a female head coach of a national rugby union team were recorded in both training and competition, across a whole rugby season, using the newly developed Rugby Coach Activities and Behaviours Instrument (RCABI). The instrument incorporates 24 categories of behaviour, embedded within three forms of activity (training form (TF), playing form (PF) and competitive match) and seven sub-activity types. In contrast to traditional drill-based coaching, 58.5% of the training time was found to have been spent in PF activities. Moreover, the proportion of PF activities increased to a peak average of 83.8% in proximity to the team's annual international championship. Uniquely, one of the coach's most prolific behaviours was conferring with associates (23.3%), highlighting the importance of interactions with assistant coaches, medical staff and others in shaping the coaching process. Additionally, the frequencies of key behaviours such as questioning and praise were found to vary between the different activity forms and types, raising questions about previous conceptions of effective coaching practice. The findings are discussed in the light of the Game Sense philosophy and the role of the head coach. PMID:26260577

  2. 12 CFR 723.2 - What are the prohibited activities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What are the prohibited activities? 723.2 Section 723.2 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MEMBER BUSINESS LOANS § 723.2 What are the prohibited activities? (a) Who is ineligible to receive a member business loan? You may not grant a...

  3. The employed professional and trade unionism.

    PubMed

    Stanford, J D

    1975-09-01

    Trade unions are often in the news and their activities subject to much critical comment. Many professional people may feel that trade union activities and professional standards are in conflict. This paper argues that professional workers in employment can engage in trade union activity in a way which is compatible with professional standards of behaviour. Furthermore, it is suggested, greater involvement of professional workers in trade unions can be a creative and constructive force for better trade unions and better trade unionism. PMID:25025541

  4. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

    PubMed

    Eisenbeis, C F; Singh, H; Storb, U

    1995-06-01

    The immunoglobulin light-chain gene enhancers E kappa 3', E lambda 2-4, and E lambda 3-1 contain a conserved cell type-specific composite element essential for their activities. This element binds a B cell-specific heterodimeric protein complex that consists of the Ets family member PU.1 and a second factor (NF-EM5), whose participation in the formation of the complex is dependent on the presence of DNA-bound PU.1. In this report we describe the cloning and characterization of Pip (PU.1 interaction partner), a lymphoid-specific protein that is most likely NF-EM5. As expected, the Pip protein binds the composite element only in the presence of PU.1; furthermore, the formation of this ternary complex is critically dependent on phosphorylation of PU.1 at serine-148. The Pip gene is expressed specifically in lymphoid tissues in both B- and T-cell lines. When coexpressed in NIH-3T3 cells, Pip and PU.1 function as mutually dependent transcription activators of the composite element. The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma. PMID:7797077

  5. Unpacking Faculty Engagement: The Types of Activities Faculty Members Report as Publicly Engaged Scholarship during Promotion and Tenure

    ERIC Educational Resources Information Center

    Glass, Chris R.; Doberneck, Diane M.; Schweitzer, John H.

    2011-01-01

    While a growing body of scholarship has focused on the personal, professional, and organizational factors that influence faculty members' involvement in publicly engaged scholarship, the nature and scope of faculty publicly engaged scholarship itself has remained largely unexplored. What types of activities are faculty members involved in as…

  6. Members of the Chloride Intracellular Ion Channel Protein Family Demonstrate Glutaredoxin-Like Enzymatic Activity

    PubMed Central

    Al Khamici, Heba; Brown, Louise J.; Hossain, Khondker R.; Hudson, Amanda L.; Sinclair-Burton, Alxcia A.; Ng, Jane Phui Mun; Daniel, Elizabeth L.; Hare, Joanna E.; Cornell, Bruce A.; Curmi, Paul M. G.; Davey, Mary W.; Valenzuela, Stella M.

    2015-01-01

    The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins where they function as chloride selective ion channels, however no function has previously been assigned to their soluble form. Structural studies have shown that in the soluble form, CLIC proteins adopt a glutathione S-transferase (GST) fold, however, they have an active site with a conserved glutaredoxin monothiol motif, similar to the omega class GSTs. We demonstrate that CLIC proteins have glutaredoxin-like glutathione-dependent oxidoreductase enzymatic activity. CLICs 1, 2 and 4 demonstrate typical glutaredoxin-like activity using 2-hydroxyethyl disulfide as a substrate. Mutagenesis experiments identify cysteine 24 as the catalytic cysteine residue in CLIC1, which is consistent with its structure. CLIC1 was shown to reduce sodium selenite and dehydroascorbate in a glutathione-dependent manner. Previous electrophysiological studies have shown that the drugs IAA-94 and A9C specifically block CLIC channel activity. These same compounds inhibit CLIC1 oxidoreductase activity. This work for the first time assigns a functional activity to the soluble form of the CLIC proteins. Our results demonstrate that the soluble form of the CLIC proteins has an enzymatic activity that is distinct from the channel activity of their integral membrane form. This CLIC enzymatic activity may be important for protecting the intracellular environment against oxidation. It is also likely that this enzymatic activity regulates the CLIC ion channel function. PMID:25581026

  7. Novel triphosphate phosphohydrolase activity of Clostridium thermocellum TTM, a member of the triphosphate tunnel metalloenzyme superfamily.

    PubMed

    Keppetipola, Niroshika; Jain, Ruchi; Shuman, Stewart

    2007-04-20

    Triphosphate tunnel metalloenzymes (TTMs) are a newly recognized superfamily of phosphotransferases defined by a unique active site residing within an eight-stranded beta barrel. The prototypical members are the eukaryal metal-dependent RNA triphosphatases, which catalyze the initial step in mRNA capping. Little is known about the activities and substrate specificities of the scores of TTM homologs present in bacterial and archaeal proteomes, nearly all of which are annotated as adenylate cyclases. Here we have conducted a biochemical and structure-function analysis of a TTM protein (CthTTM) from the bacterium Clostridium thermocellum. CthTTM is a metal-dependent tripolyphosphatase and nucleoside triphosphatase; it is not an adenylate cyclase. We have identified 11 conserved amino acids in the tunnel that are critical for tripolyphosphatase and ATPase activity. The most salient findings are that (i) CthTTM is 150-fold more active in cleaving tripolyphosphate than ATP and (ii) the substrate specificity of CthTTM can be transformed by a single mutation (K8A) that abolishes tripolyphosphatase activity while strongly stimulating ATP hydrolysis. Our results underscore the plasticity of CthTTM substrate choice and suggest how novel specificities within the TTM superfamily might evolve through changes in the residues that line the tunnel walls. PMID:17303560

  8. History and Status of the CIS Customs Union

    SciTech Connect

    Lawson, T.M.; Erickson, S.A.

    1999-08-31

    This report explores the history of the CIS Customs Union and the major obstacles the Union faces in its implementation. Investigation of the Customs Union is necessary as its implementation could effect the Second Line of Defense (SLD) Program. Russian Customs contends that radiation detectors should not be installed along the Customs Union members borders of as the borders will be dissolved when the Union is implemented.

  9. Qualitative examination of cognitive change during PTSD treatment for active duty service members.

    PubMed

    Dondanville, Katherine A; Blankenship, Abby E; Molino, Alma; Resick, Patricia A; Wachen, Jennifer Schuster; Mintz, Jim; Yarvis, Jeffrey S; Litz, Brett T; Borah, Elisa V; Roache, John D; Young-McCaughan, Stacey; Hembree, Elizabeth A; Peterson, Alan L

    2016-04-01

    The current study investigated changes in service members' cognitions over the course of Cognitive Processing Therapy (CPT) for posttraumatic stress disorder (PTSD). Sixty-three active duty service members with PTSD were drawn from 2 randomized controlled trials of CPT-Cognitive Only (CPT-C). Participants wrote an impact statement about the meaning of their index trauma at the beginning and again at the end of therapy. Clauses from each impact statement were qualitatively coded into three categories for analysis: assimilation, accommodation, and overaccommodation. The PTSD Checklist, Posttraumatic Symptom Scale-Interview Version, and the Beck Depression Inventory-II were administered at baseline and posttreatment. Repeated measures analyses documented a significant decrease in the percentage of assimilated or overaccommodated statements and an increase in the percentage of accommodated statements from the beginning to the end of treatment. Changes in accommodated statements over the course of treatment were negatively associated with PTSD and depression symptom severity, while statements indicative of overaccommodation were positively associated with both PTSD and depression symptom severity. Treatment responders had fewer overaccommodated and more accommodated statements. Findings suggest that CPT-C changes cognitions over the course of treatment. Methodological limitations and the lack of association between assimilation and PTSD symptom severity are further discussed. PMID:26874683

  10. Commentary: experience with resident unions at one institution and implications for the future of practicing physicians.

    PubMed

    Sklar, David; Chang, Betty; Hoffman, Benjamin D

    2011-05-01

    This commentary discusses the forces behind the formation of a resident union at the University of New Mexico School of Medicine and the union's evolution over its first three years. Because unions exist primarily to provide an avenue for advocacy to their members, they could have a negative impact on resident professionalism and on the faculty-resident mentor relationship. Resident unionization could also adversely impact the perceived balance between education and clinical service, to the detriment of the professional identity development of resident physicians. Despite this concern, the authors express their initial, cautious optimism that the union is instead currently promoting resident professionalism. The resident union has provided a forum for a unified resident voice, the engagement of the residents in safety and quality improvement activities, and advocacy for, and direction of, additional patient care funds, all of which has encouraged resident professionalism. Residents who have been active in the union also seem to have maintained altruistic professional attitudes as well as engagement in their educational activities. However, as the environment changes from one of increasing resources to one of stagnant or decreasing institutional resources, inevitable conflicts will arise between advocacy for resident salaries and benefits and patient care needs, and the manner in which the resident union will balance these conflicting needs and what impact it will have on the residents' professional identity development is unclear. PMID:21646972

  11. Anoctamin/TMEM16 family members are Ca2+-activated Cl− channels

    PubMed Central

    Hartzell, H Criss; Yu, Kuai; Xiao, Qinhuan; Chien, Li-Ting; Qu, Zhiqiang

    2009-01-01

    Ca2+-activated Cl− channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects. PMID:19015192

  12. Synthesis and structure-activity relationship of vicenistatin, a cytotoxic 20-membered macrolactam glycoside.

    PubMed

    Fukuda, Hayato; Nishiyama, Yuko; Nakamura, Shiina; Ohno, Yutaro; Eguchi, Tadashi; Iwabuchi, Yoshiharu; Usui, Takeo; Kanoh, Naoki

    2012-12-01

    We have developed two syntheses of vicenistatin and its analogues. Our first-generation strategy included the rapid and sequential assembly of the macrocyclic lactam by using an intermolecular Horner-Wadsworth-Emmons reaction between the C3-C13 fragment and the C1-C2, C14-C19 fragment, followed by an intramolecular Stille coupling reaction. The second-generation strategy utilized a ring-closing metathesis of a hexaene intermediate to generate the desired 20-membered macrolactam. This second-generation strategy made it possible to prepare synthetic analogues of vicenistatin, including the C20- and/or C23-demethyl analogues. Evaluation of the cytotoxic effect of these analogues indicated the importance of the fixed conformation of aglycon for determining the biological activity of the vicenistatins. PMID:23015368

  13. Discrimination and Good Practice Activities in Education: Trends and Developments in the 27 EU Member States

    ERIC Educational Resources Information Center

    Pollak, Alexander

    2008-01-01

    The European Union Agency for Fundamental Rights collects, through its network of observation points, information on discrimination and good practice in the areas of legislation, employment, housing, racist violence, and education. Data on education includes information on: access to education for vulnerable groups, discriminatory practices,…

  14. Possible changes for mudflow and avalanche activity in former Soviet Union due to the global warming

    SciTech Connect

    Glazovskaya, T.G.; Sidorova, T.L.; Seliverstov, Y.G.

    1996-12-31

    Past research, as well as laboratory evidence have revealed a relationship between climate, mudflow, and avalanche activity. It is possible to predict changes in mudflow and avalanche activity by using climate models. In this study, the GFDL model was used which contained data on mean monthly air temperature, precipitation, and carbon dioxide concentrations.

  15. Marketing the College Union.

    ERIC Educational Resources Information Center

    Hoef, Ted; Howe, Nanci

    Theory underlying marketing in the public sector is presented in combination with specific examples of marketing strategies and techniques used in college unions and student activities programs across the country. The subject of marketing is discussed under six major subject headings: (1) why marketing? (2) analyzing marketing opportunities; (3)…

  16. Why Union Activists Write Good Stories

    ERIC Educational Resources Information Center

    Worthen, Helena H.

    2013-01-01

    The representative structure of a union is a maze which, when travelled as a narrative, has drama at every turn. It sets up expectations, pits good against evil, involves many characters with different interests, keeps the clock ticking, and offers opportunities for happy endings (and disappointments) at every level. Union members who are not…

  17. Personnel practices can help discourage unionization.

    PubMed

    Hoffman, H L

    1989-09-01

    Unionization presents a potential source of cost escalation for hospitals, particularly involving health benefits. The best way to minimize chances that staff members will opt for union representation is to develop personnel practices that demonstrate management's commitment to treating employees fairly, such as providing competitive salaries and benefits, scheduling regular meetings to address worker questions, and developing detailed policy handbooks. PMID:10294325

  18. Teachers' Unions. Roadblocks to Reform.

    ERIC Educational Resources Information Center

    Haar, Charlene K.

    1996-01-01

    The strongest players in the plight of America's public schools are the National Education Association and the American Federation of Teachers. The power of these unions rests on a bargaining monopoly and the collection of service fees from non-member teachers in most states with collective bargaining laws. Despite their rhetoric, both groups…

  19. Elastic flexure explains the offset of primary volcanic activity upstream of the Réunion and Hawaii plume axis

    NASA Astrophysics Data System (ADS)

    Gerbault, Muriel; Fontaine, Fabrice; Rabinowicz, Michel; Bystricky, Micha

    2016-04-01

    Recent tomography reveals that surface volcanism at la Réunion and Hawaii develops offset by 150-180 km upstream to the plume axis with respect to plate motion. We use elasto-visco-plastic 2D numerical models to describe the development of compressional stresses at the base of the lithosphere, resulting from elastic plate bending above the upward load exerted by the plume head. This horizontal compression is ~20 km thick, has a ~ 150 km radius and lays around ~50-70 km depth where temperature varies from ~600°C to ~750°C. It is suggested that the buoyant melts percolating in the plume head pond below this zone of compression and eventually spread laterally to the extent where compression vanishes. There, melts resume their ascension and propagate through dikes up to ~35 km depth where the field stress rotates again due to plate curvature change. Flexural compression is a transient phenomenon that depends: (i) on the relaxation time of elasto-plastic stresses between ~600° and ~750°C, (ii) on the thermal erosion of the lithosphere induced by the plume, and (iii) on the ratio of the normal versus tangential stress exerted by the plume on the lithosphere. We find that for a plate 70 My old, this horizontal compression lasts for about 5 Myrs. This time span exceeds the time during which both the Indian and Pacific plates drift over the Reunion and Hawaii plumes, respectively. Accordingly, our model explains i) the ~150 km shift between the surface volcanism and the axis of the plume, ii) the ~5 Myrs synchronous activity of the volcanoes of la Réunion and Mauritius, and (iii) the present pounding of melts at 35 km depth detected below the Reunion and Mauritius Islands. Plume-lithosphere interaction is one of the numerous subjects that Genia Burov studied and modeled; the present study uses a similar code to the one he used, and is inspired by several of his assumptions. In support of his own goals and worries, we show here the importance of thermo

  20. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  1. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  2. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  3. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  4. 34 CFR 403.188 - What is a State's responsibility for the cost of services and activities for members of special...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... services and activities for members of special populations? 403.188 Section 403.188 Education Regulations... activities for members of special populations? A State is not required to use non-Federal funds to pay the cost of services and activities that it provides to members of special populations pursuant to §...

  5. Organizational Member Involvement in Physical Activity Coalitions across the United States: Development and Testing of a Novel Survey Instrument for Assessing Coalition Functioning

    ERIC Educational Resources Information Center

    Bornstein, Daniel B.; Pate, Russell R.; Beets, Michael W.; Saunders, Ruth P.; Blair, Steven N.

    2015-01-01

    Introduction: Coalitions are often composed of member organizations. Member involvement is thought to be associated with coalition success. No instrument currently exists for evaluating organizational member involvement in physical activity coalitions. This study aimed to develop a survey instrument for evaluating organizational member involvement…

  6. 12 CFR 708a.305 - Disclosures and communications to members.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Disclosures and communications to members. 708a.305 Section 708a.305 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS BANK CONVERSIONS AND MERGERS Merger of Insured Credit Unions Into Banks § 708a.305 Disclosures and communications to members. (a)...

  7. 12 CFR 708a.305 - Disclosures and communications to members.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Disclosures and communications to members. 708a.305 Section 708a.305 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS BANK CONVERSIONS AND MERGERS Merger of Insured Credit Unions Into Banks § 708a.305 Disclosures and communications to members. (a)...

  8. Transitioning New Board of Directors Members from Peripheral Roles to Active Leadership Roles

    ERIC Educational Resources Information Center

    Ostos, Ray A.

    2013-01-01

    The National Association of Community College Teacher Education Programs (NACCTEP) was established to promote the community college role in the recruitment, preparation, retention, and renewal of teachers. NACCTEP is led by a 13-member executive board consisting of community college teacher education administrators and faculty members from across…

  9. ETUDE - European Trade Union Distance Education.

    ERIC Educational Resources Information Center

    Creanor, Linda; Walker, Steve

    2000-01-01

    Describes transnational distance learning activities among European trade union educators carried out as part of the European Trade Union Distance Education (ETUDE) project, supported by the European Commission. Highlights include the context of international trade union distance education; tutor training course; tutors' experiences; and…

  10. International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels

    PubMed Central

    Huang, Fen; Wong, Xiuming

    2012-01-01

    Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation. PMID:22090471

  11. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity

    PubMed Central

    Duquette, Mark; Nadler, Monica; Okuhara, Dayne; Thompson, Jill; Shuttleworth, Trevor; Lawler, Jack

    2015-01-01

    The thrombospondins (TSPs) are a family of matricellular proteins that regulate cellular phenotype through interactions with a myriad of other proteins and proteoglycans. We have identified a novel interaction of the members of the TSP gene family with stromal interaction molecule 1 (STIM1). This association is robust since it is preserved in Triton X-100, can be detected with multiple anti-TSP-1 and anti-STIM1 antibodies, and is detected in a wide range of cell types. We have also found that STIM1 co-immunoprecipitates with TSP-4 and cartilage oligomeric matrix protein (COMP), and that a recombinant version of the N-terminal domain of STIM1 binds to the signature domain of TSP-1 and COMP. The association of the TSPs with STIM1 is observed in both the presence and absence of calcium indicating that the calcium-dependent conformation of the signature domain of TSPs is not required for binding. Thus, this interaction could occur in the ER under conditions of normal or low calcium concentration. Furthermore, we observed that the expression of COMP in HEK 293 cells decreases STIM1-mediated calcium release activated calcium (CRAC) channel currents and increases arachidonic acid calcium (ARC) channel currents. These data indicate that the TSPs regulate STIM1 function and participate in the reciprocal regulation of two channels that mediate calcium entry into the cell. PMID:24845346

  12. Incidence of joint replacement among active component service members, U.S. Armed Forces, 2004-2014.

    PubMed

    Daniele, Denise O; Taubman, Stephen B; Clark, Leslie L

    2015-05-01

    In the U.S., joint replacements have become more common and the average age of individuals who undergo joint replacements has decreased. Joint replacements among active component service members increased 10.5% during 2004-2009, then 61.9% during 2009-2014. Knees and hips were the most frequently replaced joints among service members. During the surveillance period (and particularly after 2009), incidence rates increased in each age group of service members 30 years or older. Relative to their respective counterparts, rates of joint replacement overall--and of the hip and knee specifically--were higher among service members who were black, non-Hispanic; officers; and healthcare workers. One year after joint replacement, 18.2% had retired; 5.2% had been medically disqualified from service; 6.3% had otherwise left service; and 70.3% were still in service. By 2 years post-joint replacement, 30.2% had retired; 13.0% had been medically disqualified; 10.0% had otherwise left service; and 46.8% were still in service. Service members aged 30-44 years were the most likely to remain in service post-joint replacement. Given the increases in the frequency of joint replacement among younger service members, the number of service members who remain in service post-joint replacement may continue to increase. PMID:25996170

  13. Radioactive contamination of the Arctic Region, Baltic Sea, and the Sea of Japan from activities in the former Soviet Union

    SciTech Connect

    Bradley, D.J.

    1992-09-01

    Contamination of the Arctic regions of northern Europe and Russia, as well as the Sea of Japan, may become a potential major hazard to the ecosystem of these large areas. Widespread poor radioactive waste management practices from nuclear fuel cycle activities in the former Soviet Union have resulted in direct discharges to this area as well as multiple sources that may continue to release additional radioactivity. Information on the discharges of radioactive materials has become more commonplace in the last year, and a clearer picture is emerging of the scale of the contamination. Radioactivity in the Arctic oceans is now reported to be four times higher than would be derived from fallout from weapons tests. Although the characteristics and extent of the contamination are not well known, it has been stated that the contamination in the Arctic may range from 1 to 3.5 billion curies. As yet, no scientific sampling or measurement program has occurred that can verify the amount or extent of the contamination, or its potential impact on the ecosystem.

  14. Suicide Attempt Characteristics Among Veterans and Active-Duty Service Members Receiving Mental Health Services: A Pooled Data Analysis

    PubMed Central

    Villatte, Jennifer L.; O’Connor, Stephen S.; Leitner, Rebecca; Kerbrat, Amanda H.; Johnson, Lora L.; Gutierrez, Peter M.

    2015-01-01

    Past suicidal behaviors are among the strongest and most consistent predictors of eventual suicide and may be particularly salient in military suicide. The current study compared characteristics of suicide attempts in veterans (N = 746) and active-duty service members (N = 1,013) receiving treatment for acute suicide risk. Baseline data from six randomized controlled trials were pooled and analyzed using robust regression. Service members had greater odds of having attempted suicide relative to veterans, though there were no differences in number of attempts made. Service members also had higher rates of premilitary suicide attempts and nonsuicidal self-injury (NSSI). Veterans disproportionately attempted suicide by means of overdose. In veterans, combat deployment was associated with lower odds of lifetime suicide attempt, while history of NSSI was associated with greater attempt odds. Neither was significantly associated with lifetime suicide attempt in service members. Implications for suicide assessment and treatment are discussed. PMID:26740909

  15. Union Membership and Political Participation in the United States

    ERIC Educational Resources Information Center

    Kerrissey, Jasmine; Schofer, Evan

    2013-01-01

    This article examines the effect of union membership on civic and political participation in the late 20th century in the United States. We discuss why and how unions seek to mobilize their members and where mobilization is channeled. We argue that union membership affects electoral and collective action outcomes and will be larger for low…

  16. Learning, Labour and Union Learning Representatives: Promoting Workplace Learning

    ERIC Educational Resources Information Center

    Ball, Malcolm

    2011-01-01

    The initiative by the Trades Union Congress (TUC) and affiliated trade unions in the UK to appoint trade union learning representatives (ULRs), to promote learning among their members, is a significant development in adult learning. Understandably, the initiative has attracted the attention of academic researchers, but primarily from the…

  17. GapIII, a new brain-enriched member of the GTPase-activating protein family.

    PubMed

    Baba, H; Fuss, B; Urano, J; Poullet, P; Watson, J B; Tamanoi, F; Macklin, W B

    1995-08-15

    Ras GTPase-activating proteins (GAPs) are negative regulators of ras, which controls proliferation and differentiation in many cells. Ras GAPs have been found in a variety of species from yeast to mammals. We describe here a newly identified mammalian GAP, GapIII, which was obtained by differential screening of a rat oligodendrocyte cDNA library. GapIII putatively encodes a 834 amino acid protein with a predicted molecular weight of 96 kDa, which contains a consensus GAP-related domain (GRD). The protein encoded by this cDNA has high homology with Gap1m, which was recently identified as a putative mammalian homolog of Drosophila Gap1. These proteins contain three structural domains, an N-terminal calcium-dependent phospholipid binding domain, GRD, and a C-terminal PH/Btk domain. Because of the sequence homology and the structural similarities of this protein with Gap1m, we hypothesize that GapIII and Gap1m may be members of a mammalian GAP gene family, separate from p120GAP, neurofibromin (NF1), and IQGAP. To confirm the GapIII protein activity, constructs containing different GapIII-GRD domains were transformed into iral mutant yeast to determine their relative ability to replace IRA1 functionally. Constructs that contained essentially the full-length protein (all three domains), the GRD alone, or the GRD plus PH/Btk domain suppressed heat shock sensitivity of ira1, whereas constructs that contained the GRD with part of the PH/Btk domain had only a weak ability to suppress heat shock sensitivity. These results suggest that the GapIII GRD itself is sufficient to down-regulate ras proteins in yeast. Expression of GapIII mRNA (4.2 kb) was examined by Northern analysis and in situ hybridization. This mRNA was expressed at highest levels in the brain, where its expression increased with development. Lower levels of the mRNA were expressed in the spleen and lung. Among neural cells, GapIII mRNA was expressed in neurons and oligodendrocytes, but not in astrocytes

  18. Supporting Members and Friends

    NASA Astrophysics Data System (ADS)

    2005-10-01

    Thank you! Over the past year, AGU has received 12,104 gifts, both large and small, from members and friends. The Union has also received corporate contributions, National Science Foundation grants, and support from the National Oceanographic Partnership Program and National Association of Geoscience Teachers. Together their generosity has benefited AGU non revenue producing programs that are critical to our science and the future health of the Union. The following list gratefully acknowledges annual gifts of $100 or more and cumulative giving of $5,000 or more. The 1919 Society ($100,000 or more) and Benefactors ($5,000-$99,999) recognize single major gifts and cumulative contributions. Three circles acknowledge annual giving: President's Circle ($1,000 or more), Leadership Circle ($200-$999), and Supporters Circle ($100-$199). Supporting Life Members, who contribute a one-time gift of $1,200 in addition to lifetime dues, are among our most loyal Supporters.

  19. Supporting Members and Friends

    NASA Astrophysics Data System (ADS)

    2004-09-01

    Thank you! Over the past 20 months AGU has received a record 22,159 gifts, both large and small, from members and friends. The Union has also received corporate contributions, National Science Foundation grants, and support from four federal agencies (NASA, NOAA, EPA, and USGS). Together their generosity has benefited AGU non-revenue producing programs that are critical to our science and the future health of the Union. The following list gratefully acknowledges annual gifts of $100 or more and cumulative giving of $5000 or more. The 1919 Society ($100,000+) and Benefactors ($5,000-$99,999) recognize single major and cumulative contributions. Three circles acknowledge annual giving: President's Circle ($1,000 or more), Leadership Circle ($250-$999), and Supporters Circle ($100-$249). Supporting Life Members, who contribute a one-time gift of $1,200 in addition to lifetime dues, are recognized as our most loyal Supporters.

  20. 24 CFR 960.204 - Denial of admission for criminal activity or drug abuse by household members.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false Denial of admission for criminal activity or drug abuse by household members. 960.204 Section 960.204 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN DEVELOPMENT (CONTINUED) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING...

  1. Supporting School Success for Homeless Children of Veterans and Active Duty Military Members. Best Practices in Interagency Collaboration

    ERIC Educational Resources Information Center

    National Center for Homeless Education at SERVE, 2011

    2011-01-01

    This brief is designed for local staff of the Department of Veterans Affairs (VA), state McKinney-Vento coordinators and school district McKinney-Vento liaisons, educators, and other providers of services to active members of the military and veterans, and their children. It provides basic information to assist homeless children of veterans or…

  2. Army Active Duty Members' Linkage to Veterans Health Administration Services After Deployments to Iraq or Afghanistan and Following Separation.

    PubMed

    Vanneman, Megan E; Harris, Alex H S; Chen, Cheng; Mohr, Beth A; Adams, Rachel Sayko; Williams, Thomas V; Larson, Mary Jo

    2015-10-01

    This study described the rate and predictors of Operation Enduring Freedom/Operation Iraqi Freedom active duty Army members' enrollment in and use of Veterans Health Administration (VHA) services (linkage), as well as variation in linkage rates by VHA facility. We used a multivariate mixed effect regression model to predict linkage to VHA, and also calculated linkage rates in the catchment areas of each facility (n = 158). The sample included 151,122 active duty members who deployed to Iraq or Afghanistan and then separated from the Army between fiscal years 2008 and 2012. Approximately 48% of the active duty members separating utilized VHA as an enrollee within one year. There was significant variation in linkage rates by VHA facilities (31-72%). The most notable variables associated with greater linkage included probable serious injury during index deployment (odds ratio = 1.81), separation because of disability (odds ratio = 2.86), and various measures of receipt of VHA care before and after separation. Information about the individual characteristics that predict greater or lesser linkage to VHA services can be used to improve delivery of health care services at VHA as well as outreach efforts to active duty Army members. PMID:26444467

  3. Unions, Vitamins, Exercise: Unionized Graduate Students

    ERIC Educational Resources Information Center

    Dewberry, David R.

    2005-01-01

    After the turbulent labor history of America in the early to mid twentieth century, there has been a general decline of unions. Nevertheless, many graduate school teaching assistants are unionizing in attempts to gain better pay and benefits and remove themselves from an "Ivory Sweatshop." This article discusses a history of unions within graduate…

  4. A Beach and Dune Community. 4-H Marine Science. Member's Guide. Activity I. MSp 1.

    ERIC Educational Resources Information Center

    Auburn Univ., AL. Cooperative Extension Service.

    The investigation in this booklet is designed to provide 4-H members with opportunities to identify common plants and animals found on beaches and sand dunes and to determine the role of the plants and animals in this community. Learners are provided with a picture of a hypothetical beach and sand dune and a list of organisms (included in the…

  5. Approaches for analyzing the differential activities and functions of eIF4E family members.

    PubMed

    Rhoads, Robert E; Dinkova, Tzvetanka D; Jagus, Rosemary

    2007-01-01

    The translational initiation factor eIF4E binds to the m(7)G-containing cap of mRNA and participates in recruitment of mRNA to ribosomes for protein synthesis. eIF4E also functions in nucleocytoplasmic transport of mRNA, sequestration of mRNA in a nontranslatable state, and stabilization of mRNA against decay in the cytosol. Multiple eIF4E family members have been identified in a wide range of organisms that includes plants, flies, mammals, frogs, birds, nematodes, fish, and various protists. This chapter reviews methods that have been applied to learn the biochemical properties and physiological functions that differentiate eIF4E family members within a given organism. Much has been learned to date about approaches to discover new eIF4E family members, their in vitro properties (cap binding, stimulation of cell-free translation systems), tissue and developmental expression patterns, protein-binding partners, and their effects on the translation or repression of specific subsets of mRNA. Despite these advances, new eIF4E family members continue to be found and new physiological roles discovered. PMID:17913628

  6. Work activity of persons working as members of advisory committees established under the Federal Advisory Committee Act (FACA). Final rule.

    PubMed

    2006-01-20

    We are revising our disability regulations under titles II and XVI of the Social Security Act to establish a new, special rule that affects individuals who are receiving payments or providing services as members or consultants of a committee, board, commission, council or similar group established under the Federal Advisory Committee Act (FACA). Under this special rule, we will not count any earnings an individual is receiving from serving as a member or consultant of a FACA advisory committee when we determine if the individual is engaging in substantial gainful activity under titles II and XVI of the Social Security Act (the Act). In addition, we will not evaluate any of the services the individual is providing as a member or consultant of the FACA advisory committee when determining if the individual has engaged in substantial gainful activity under titles II and XVI of the Act. Based on our experience with FACA advisory committees and the frequency and level of activity required by these committees, we believe that performance of activity on these committees does not demonstrate the ability to perform substantial gainful activity. We believe this to be consistent with Congress's view, as it has recognized in creating the Ticket to Work advisory committee, for example, that current disability beneficiaries should be considered for membership. This also will encourage individuals with disabilities to serve on FACA advisory committees, thereby providing the benefit of their unique perspective on policies and programs to the Federal Government. PMID:16479696

  7. Teacher Unionism in Changing Times: Is This the Real "New Unionism"?

    ERIC Educational Resources Information Center

    Stevenson, Howard

    2015-01-01

    This article provides a case study of union change in an environment in which radical school restructuring is taking place, and active strategies to weaken and marginalize organized teachers are being pursued by the state. The case study union is the National Union of Teachers in England. The article explores a number of different strategies open…

  8. Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members*

    PubMed Central

    Suzuki, Jun; Fujii, Toshihiro; Imao, Takeshi; Ishihara, Kenji; Kuba, Hiroshi; Nagata, Shigekazu

    2013-01-01

    Asymmetrical distribution of phospholipids between the inner and outer plasma membrane leaflets is disrupted in various biological processes. We recently identified TMEM16F, an eight-transmembrane protein, as a Ca2+-dependent phospholipid scramblase that exposes phosphatidylserine (PS) to the cell surface. In this study, we established a mouse lymphocyte cell line with a floxed allele in the TMEM16F gene. When TMEM16F was deleted, these cells failed to expose PS in response to Ca2+ ionophore, but PS exposure was elicited by Fas ligand treatment. We expressed other TMEM16 proteins in the TMEM16F−/− cells and found that not only TMEM16F, but also 16C, 16D, 16G, and 16J work as lipid scramblases with different preference to lipid substrates. On the other hand, a patch clamp analysis in 293T cells indicated that TMEM16A and 16B, but not other family members, acted as Ca2+-dependent Cl− channels. These results indicated that among 10 TMEM16 family members, 7 members could be divided into two subfamilies, Ca2+-dependent Cl− channels (16A and 16B) and Ca2+-dependent lipid scramblases (16C, 16D, 16F, 16G, and 16J). PMID:23532839

  9. State of the Unions

    ERIC Educational Resources Information Center

    Blair, Julie

    2004-01-01

    This article discusses the corrupt leadership of two big-city teachers' unions, the Washington Teachers Union (WTU) and its Miami cousin, United Teachers of Dade (UTD), that took both unions to the brink of despair and financial ruin. While the feds were rifling through union files to build extensive criminal investigations, congress called Sandra…

  10. Procedure for developing Union position

    NASA Astrophysics Data System (ADS)

    1. Position statements will be restricted to those issues that fall within the guidelines approved by the Council. 2. Requests for position statements are referred immediately to the Public Affairs Committee. 3. If a request seems to fall within Union guidelines, the committee will recommend that the President of the Union appoint an independent panel charged with drafting a statement. The panel will include at least one member nominated by the Public Affairs Committee, the originator of the request, and one member of Council. 4. The Council and the membership will be informed that the panel is working on the issue and that comments are welcome. 5. The panel will prepare a statement for circulation to the Council of the Union. 6. Members of Council (or Executive Committee when timeliness is critical) will be asked to vote or to comment on the proposed statement. This vote is to be taken at regularly scheduled meetings except where timeliness is critical. Concurrence of two thirds is required for adoption. 7. All adopted position statements will be published in Eos as soon as possible. 8. Once a statement has been approved, the Public Affairs Committee will endeavor to apply its expertise to making advocacy of its contents as effective as possible.

  11. Incidence of hiatal hernia in service members, active component, U.S. Armed Forces, 2005-2014.

    PubMed

    O'Donnell, Francis L; Taubman, Stephen B

    2016-08-01

    From 2005 through 2014, a total of 27,276 active component service members had incident diagnoses of hiatal hernia documented in their medical records. The overall incidence rate was 19.7 cases per 10,000 person-years (p-yrs); annual incidence rates ranged from 16.5 to 22.2 cases per 10,000 p-yrs. Rates overall increased monotonically with increasing age and were higher among Air Force and Army members, officers, and healthcare workers than their respective counterparts. During the surveillance period, the 27,276 service members who had incident diagnoses of hiatal hernia accounted for 44,092 hiatal hernia-related encounters overall (1.6 encounters per case). Among all incident cases, 235 (0.86%) had surgical repairs documented during the period. The frequency of surgical treatment of hiatal hernias among military members mirrored the low frequency in U.S. civilian practice. During 2010-2014, most surgical procedures (79%) were accomplished via laparoscopic approaches. The incidence rates of hiatal hernia diagnoses reported here likely greatly underestimate the true incidence in U.S. military populations. Reasons for the underestimates and comparisons with other populations are discussed. PMID:27602798

  12. Become an AGU Supporting Member

    NASA Astrophysics Data System (ADS)

    You can extend your commitment to the continuing vitality .of geophysics by helping AGU to build funds that will provide for new initiatives and assist in funding some of the nonrevenue programs of AGU, such as the congressional science fellowship, minority student scholarships, and student travel grants. The AGU Development Committee is seeking gifts and contributions toward building the endowment of the Union: The vitality of AGU and the vitality of geophysics march hand in hand.Four categories of supporting membership are offered by the Union: Individual Supporting Member ($80 per year), Life Supporting Member ($1500), Sustaining Member ($5000), Benefactor ($10,000). Benefactors, Sustaining, and Life Supporting Members pay no further dues.

  13. Active member control of a precision structure with an H(infinity) performance objective

    NASA Technical Reports Server (NTRS)

    Fanson, J. L.; Chu, C.-C.; Smith, R. S.; Anderson, E. H.

    1990-01-01

    This paper addresses the noncollocated control of active structures using active structural elements. A top level architecture for active structures is presented, and issues pertaining to robust control of structures are discussed. Controllers optimized for an H sub inf performance specification are implemented on a test structure and the results are compared with analytical predictions. Directions for further research are identified.

  14. Entamoeba histolytica: a unicellular organism containing two active genes encoding for members of the TBP family.

    PubMed

    Castañon-Sanchez, Carlos Alberto; Luna-Arias, Juan Pedro; de Dios-Bravo, Ma Guadalupe; Herrera-Aguirre, Maria Esther; Olivares-Trejo, Jose J; Orozco, Esther; Hernandez, Jose Manuel

    2010-03-01

    Entamoeba histolytica is the protozoan parasite which causes human amoebiasis. In this parasite, few encoding genes for transcription factors have been cloned and characterized. The E. histolytica TATA-box binding protein (EhTBP) is the first basal transcription factor that has been studied. To continue with the identification of other members of the basal transcription machinery, we performed an in silico analysis of the E. histolytica genome and found three loci encoding for polypeptides with similarity to EhTBP. One locus has a 100% identity to the previously Ehtbp gene reported by our group. The second locus encodes for a 212 aa polypeptide that is 100% identical to residues 23-234 from EhTBP. The third one encodes for a 216 aa polypeptide of 24kDa that showed 42.6% identity and 73.7% similarity to EhTBP. This protein was named E. histolytica TBP-related factor 1 (EhTRF1). Ehtrf1 gene was expressed in bacteria and the purified 28kDa recombinant polypeptide showed the capacity to bind to TATTTAAA-box by electrophoretic mobility shift assays. K(D) values for rEhTBP and rEhTRF1 were (1.71+/-2.90)x10(-12)M and (1.12+/-0.160)x10(-11)M, respectively. Homology modeling of EhTRF1 and EhTBP revealed that, although they were very similar, they showed some differences on their surfaces. Thus, E. histolytica is a unicellular organism having two members of the TBP family. PMID:20026212

  15. 12 CFR 708b.206 - Share insurance communications to members.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Share insurance communications to members. 708b.206 Section 708b.206 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MERGERS OF FEDERALLY-INSURED CREDIT UNIONS; VOLUNTARY TERMINATION OR CONVERSION OF INSURED STATUS Voluntary Termination or Conversion...

  16. The 1998-2002 activity of Piton de la Fournaise, Réunion island: lessons in magma supply and transfers

    NASA Astrophysics Data System (ADS)

    Semet, M. P.; Joron, J.-L.; Staudacher, T.

    2003-04-01

    In March 1998, Piton de la Fournaise, one of the most frequently active aerial volcanoes on earth, awoke after an unusually long sleep of almost 6 years. This eruption, which was also preceded and accompanied by uncommon patterns of seismicity and deformation (Staudacher et al., 1998), lasted about six months and was followed to the end of 2002 by 9 eruptive episodes of about one week to a little more than a month duration. In these episodes, seismicity and deformations were those more customarily observed. The total amount of erupted magma over this 5 year period amounts to ca. 120 Mm3, which yields an average production rate close to 0.3 m3/s. Suites of lava samples were regularly obtained for each of these episodes, often as water-quenched molten lava, and examined in the laboratory for their petrography and geochemistry. Two subtly differing magmas were erupted in the 1998 episode from two locations. The voluminous lavas vented North of the central cone (Kapor and related vents) were of the ordinary Steady State Basalts (SSB) type modeled by Albarède et al. (1997) yet showed minor but significant evolution through the six months of eruption. Those vented to the South of the cone (Hudson crater) were apparently fed directly and rapidly from depths ca. 15 km, the crust-upper-mantle boundary under Réunion. Hudson samples are of a type observed mostly in peripheral vents but rarely in central eruptions. They are characterized by major and trace element signatures indicating enhanced clinopyroxene fractionation (a high pressure fractionating phase) relative to SSB. In the subsequent 9 eruptions, lavas were again of the SSB kindred, sometimes rich (50 modal %) in cumulative xenocrystic olivine (e.g. June 2001 and January, 2002). Significant chemical differences with the Kapor trend indicate that they were not fed from the same reservoir nor were they akin to Hudson samples. Glass analyses in the quenched post-1998 samples have an almost invariable composition

  17. Group Member or Outsider: Perceptions of Undergraduates with Disabilities on Leisure Time Physical Activity

    ERIC Educational Resources Information Center

    Devine, Mary Ann

    2013-01-01

    College provides students with many opportunities to achieve academic success and enrich other aspects of their lives. Participating in campus activities can reduce stress, create social connections, promote healthy active living, and broaden civic engagement (Lindsey & Sessoms, 2006; Watson, Ayers, Zizzi, & Naoi, 2006). Studies noting…

  18. A lepidopteran pacifastin member: cloning, gene structure, recombinant production, transcript profiling and in vitro activity.

    PubMed

    Breugelmans, Bert; Simonet, Gert; van Hoef, Vincent; Van Soest, Sofie; Smagghe, Guy; Vanden Broeck, Jozef

    2009-07-01

    Members of the pacifastin family have been characterized as serine peptidase inhibitors (PI), but their target enzyme(s) are unknown in insects. So far, the structural and biochemical characteristics of pacifastin-like PI have only been studied in locusts. Here we report the molecular identification and functional characterization of a pacifastin-like precursor in a lepidopteran insect, i.e. the silkworm Bombyx mori. The bmpp-1 gene contains 17 exons and codes for two pacifastin-related precursors of different length. The longest splice variant encodes 13 inhibitor domains, more than any other pacifastin-like precursor in arthropods. The second transcript lacks two exons and codes for 11 inhibitor domains. By studying the expression profile of the Bombyx pacifastin-like gene a different expression pattern for the two variants was observed suggesting functional diversification. Next, several PI domains of BMPP-1 were produced and, contrary to locust pacifastin peptides, they were found to be potent inhibitors of both bovine trypsin and chymotrypsin. Surprisingly, the same Bombyx PI are only weak inhibitors of endogenous digestive peptidases, indicating that other peptidases are the in vivo targets. Interestingly, the Bombyx PI inhibit a fungal trypsin-like cuticle degrading enzyme, suggesting a protective function for BMPP-1 against entomopathogenic fungi. PMID:19364530

  19. GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program

    PubMed Central

    Hopkin, Amelia Soto; Gordon, William; Klein, Rachel Herndon; Espitia, Francisco; Daily, Kenneth; Zeller, Michael; Baldi, Pierre; Andersen, Bogi

    2012-01-01

    The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes. PMID:22829784

  20. 45 CFR 2520.25 - What direct service activities may AmeriCorps members perform?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... activities that provide a direct, measurable benefit to an individual, a group, or a community. (d) Examples... to, the following: (1) Tutoring children in reading; (2) Helping to run an after-school program;...

  1. Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity

    PubMed Central

    Aslam, Kiran; Hazbun, Tony R.

    2016-01-01

    ABSTRACT Among different types of protein aggregation, amyloids are a biochemically well characterized state of protein aggregation that are associated with a large number of neurodegenerative diseases including Parkinson's disease, Alzheimer and Creutzfeldt-Jakob disease. Yeast, Saccharomyces cerevisiae is an insightful model to understand the underlying mechanism of protein aggregation. Many yeast molecular chaperones can modulate aggregation and misfolding of proteins including α-Syn and the Sup35 prion. Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily. An emerging view is that Hsp31 and its associated superfamily members each have divergent multitasking functions that have the common theme of responding and managing various types of cellular stress. Hsp31 has several biochemical activities including chaperone and detoxifying enzyme activities that modulate at various points of a stress pathway such as toxicity associated with protein misfolding. However, we have shown the protective role of Hsp31's chaperone activity can operate independent of detoxifying enzyme activities in preventing the early stages of protein aggregate formation and associated cellular toxicities. We provide additional data that collectively supports the multiple functional roles that can be accomplished independent of each other. We present data indicating Hsp31 purified from yeast is more active compared to expression and purification from E. coli suggesting that posttranslational modifications could be important for Hsp31 to be fully active. We also compare the similarities and differences in activities among paralogs of Hsp31 supporting a model in which this protein family has overlapping but diverging roles in responding to various sources of cellular stresses. PMID:27097320

  2. Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity.

    PubMed

    Aslam, Kiran; Hazbun, Tony R

    2016-03-01

    Among different types of protein aggregation, amyloids are a biochemically well characterized state of protein aggregation that are associated with a large number of neurodegenerative diseases including Parkinson's disease, Alzheimer and Creutzfeldt-Jakob disease. Yeast, Saccharomyces cerevisiae is an insightful model to understand the underlying mechanism of protein aggregation. Many yeast molecular chaperones can modulate aggregation and misfolding of proteins including α-Syn and the Sup35 prion. Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily. An emerging view is that Hsp31 and its associated superfamily members each have divergent multitasking functions that have the common theme of responding and managing various types of cellular stress. Hsp31 has several biochemical activities including chaperone and detoxifying enzyme activities that modulate at various points of a stress pathway such as toxicity associated with protein misfolding. However, we have shown the protective role of Hsp31's chaperone activity can operate independent of detoxifying enzyme activities in preventing the early stages of protein aggregate formation and associated cellular toxicities. We provide additional data that collectively supports the multiple functional roles that can be accomplished independent of each other. We present data indicating Hsp31 purified from yeast is more active compared to expression and purification from E. coli suggesting that posttranslational modifications could be important for Hsp31 to be fully active. We also compare the similarities and differences in activities among paralogs of Hsp31 supporting a model in which this protein family has overlapping but diverging roles in responding to various sources of cellular stresses. PMID:27097320

  3. A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase*

    PubMed Central

    Kohli, Rahul M.; Abrams, Shaun R.; Gajula, Kiran S.; Maul, Robert W.; Gearhart, Patricia J.; Stivers, James T.

    2009-01-01

    Enzymes of the AID/APOBEC family, characterized by the targeted deamination of cytosine to generate uracil within DNA, mediate numerous critical immune responses. One family member, activation-induced cytidine deaminase (AID), selectively introduces uracil into antibody variable and switch regions, promoting antibody diversity through somatic hypermutation or class switching. Other family members, including APOBEC3F and APOBEC3G, play an important role in retroviral defense by acting on viral reverse transcripts. These enzymes are distinguished from one another by targeting cytosine within different DNA sequence contexts; however, the reason for these differences is not known. Here, we report the identification of a recognition loop of 9–11 amino acids that contributes significantly to the distinct sequence motifs of individual family members. When this recognition loop is grafted from the donor APOBEC3F or 3G proteins into the acceptor scaffold of AID, the mutational signature of AID changes toward that of the donor proteins. These loop-graft mutants of AID provide useful tools for dissecting the biological impact of DNA sequence preferences upon generation of antibody diversity, and the results have implications for the evolution and specialization of the AID/APOBEC family. PMID:19561087

  4. Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members.

    PubMed

    Otto, Markus; Naumann, Christin; Brandt, Wolfgang; Wasternack, Claus; Hause, Bettina

    2016-01-01

    Jasmonates (JAs) are lipid-derived signals in plant stress responses and development. A crucial step in JA biosynthesis is catalyzed by allene oxide cyclase (AOC). Four genes encoding functional AOCs (AOC1, AOC2, AOC3 and AOC4) have been characterized for Arabidopsis thaliana in terms of organ- and tissue-specific expression, mutant phenotypes, promoter activities and initial in vivo protein interaction studies suggesting functional redundancy and diversification, including first hints at enzyme activity control by protein-protein interaction. Here, these analyses were extended by detailed analysis of recombinant proteins produced in Escherichia coli. Treatment of purified AOC2 with SDS at different temperatures, chemical cross-linking experiments and protein structure analysis by molecular modelling approaches were performed. Several salt bridges between monomers and a hydrophobic core within the AOC2 trimer were identified and functionally proven by site-directed mutagenesis. The data obtained showed that AOC2 acts as a trimer. Finally, AOC activity was determined in heteromers formed by pairwise combinations of the four AOC isoforms. The highest activities were found for heteromers containing AOC4 + AOC1 and AOC4 + AOC2, respectively. All data are in line with an enzyme activity control of all four AOCs by heteromerization, thereby supporting a putative fine-tuning in JA formation by various regulatory principles. PMID:27135223

  5. Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members

    PubMed Central

    Otto, Markus; Naumann, Christin; Brandt, Wolfgang; Wasternack, Claus; Hause, Bettina

    2016-01-01

    Jasmonates (JAs) are lipid-derived signals in plant stress responses and development. A crucial step in JA biosynthesis is catalyzed by allene oxide cyclase (AOC). Four genes encoding functional AOCs (AOC1, AOC2, AOC3 and AOC4) have been characterized for Arabidopsis thaliana in terms of organ- and tissue-specific expression, mutant phenotypes, promoter activities and initial in vivo protein interaction studies suggesting functional redundancy and diversification, including first hints at enzyme activity control by protein-protein interaction. Here, these analyses were extended by detailed analysis of recombinant proteins produced in Escherichia coli. Treatment of purified AOC2 with SDS at different temperatures, chemical cross-linking experiments and protein structure analysis by molecular modelling approaches were performed. Several salt bridges between monomers and a hydrophobic core within the AOC2 trimer were identified and functionally proven by site-directed mutagenesis. The data obtained showed that AOC2 acts as a trimer. Finally, AOC activity was determined in heteromers formed by pairwise combinations of the four AOC isoforms. The highest activities were found for heteromers containing AOC4 + AOC1 and AOC4 + AOC2, respectively. All data are in line with an enzyme activity control of all four AOCs by heteromerization, thereby supporting a putative fine-tuning in JA formation by various regulatory principles. PMID:27135223

  6. The Symposium Report. General Discussion. Current Workers' Education Approaches and Activities in Trade Union Development. Considerations for the Furthering of Development Education within Workers' Education.

    ERIC Educational Resources Information Center

    Labour Education, 1986

    1986-01-01

    The Symposium on Special Issues for Workers' Education in Industrialized Countries covered several topics: trade union opinions, the need for public debate, development education, new trends, investments and respect for union rights, union solidarity, resources allocated to workers' education, the role of the International Labor Office, and right…

  7. Users and Union Catalogues

    ERIC Educational Resources Information Center

    Hartley, R. J.; Booth, Helen

    2006-01-01

    Union catalogues have had an important place in libraries for many years. Their use has been little investigated. Recent interest in the relative merits of physical and virtual union catalogues and a recent collaborative project between a physical and several virtual union catalogues in the United Kingdom led to the opportunity to study how users…

  8. Amino acids and peptides activate at least five members of the human bitter taste receptor family.

    PubMed

    Kohl, Susann; Behrens, Maik; Dunkel, Andreas; Hofmann, Thomas; Meyerhof, Wolfgang

    2013-01-01

    Amino acids and peptides represent important flavor molecules eliciting various taste sensations. Here, we present a comprehensive assessment of the interaction of various peptides and all proteinogenic amino acids with the 25 human TAS2Rs expressed in cell lines. L-Phenylalanine and L-tryptophan activate TAS2R1 and TAS2R4, respectively, whereas TAS2R4 and TAS2R39 responded to D-tryptophan. Structure-function analysis uncovered the basis for the lack of stereoselectivity of TAS2R4. The same three TAS2Rs or subsets thereof were also sensitive to various dipeptides containing L-tryptophan, L-phenylalanine, or L-leucine and to Trp-Trp-Trp, whereas Leu-Leu-Leu specifically activated TAS2R4. Trp-Trp-Trp also activated TAS2R46 and TAS2R14. Two key bitter peptides from Gouda cheese, namely, Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn-Ser and Leu-Val-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn, both activated TAS2R1 and TAS2R39. Thus, the data demonstrate that the bitterness of amino acids and peptides is not mediated by specifically tuned TAS2Rs but rather is brought about by an unexpectedly complex pattern of sensitive TAS2Rs. PMID:23214402

  9. Early Childhood Teachers' and Staff Members' Perceptions of Nutrition and Physical Activity Practices for Preschoolers

    ERIC Educational Resources Information Center

    Derscheid, Linda E.; Umoren, Josephine; Kim, So-Yeun; Henry, Beverly W.; Zittel, Lauriece L.

    2010-01-01

    Child care teachers and staff are important influences on preschoolers' nutrition and physical activity habits, and their views may be influenced by education level, years of field experience, and program involvement. For the 360 participants surveyed, responses on 5 of 18 survey items significantly differed by education level (e.g., less…

  10. Food Service and the College Union. College Unions at Work.

    ERIC Educational Resources Information Center

    Osterheld, Douglas C.

    This publication, one in a series of monographs on college unions, explores the importance, role, and function of food services in the college union. Major topics discussed include: (1) food service and the college union, (2) union food service and the campus, (3) union food service and the community, (4) organization of union food services, (5)…

  11. SLEEPLESS, a Ly–6/Neurotoxin Family Member, Regulates Levels, Localization, and Activity of Shaker

    PubMed Central

    Wu, Mark N.; Joiner, William J.; Dean, Terry; Yue, Zhifeng; Smith, Corinne J.; Chen, Dechun; Hoshi, Toshinori; Sehgal, Amita; Koh, Kyunghee

    2009-01-01

    Sleep is a whole–organism phenomenon accompanied by global changes in neural activity. We previously identified SLEEPLESS (SSS) as a novel glycosylphosphatidyl–inositol–anchored protein required for sleep in Drosophila. Here, we demonstrate a critical role for SSS in regulating the sleep–modulating potassium channel, Shaker. SSS and Shaker exhibit similar expression patterns in the brain and specifically affect each other’s expression levels. sss mutants exhibit altered Shaker localization, reduced Shaker current density, and slower Shaker current kinetics. Transgenic expression of sss in sss mutants rescues defects in Shaker expression and activity cell–autonomously and also suggests that SSS functions in wake–promoting, cholinergic neurons. Importantly, in heterologous cells, SSS accelerates kinetics of Shaker currents and can be co–immunoprecipitated with Shaker, suggesting that SSS interacts with Shaker and modulates its activity. SSS is predicted to belong to the Ly–6/neurotoxin superfamily, suggesting a novel mechanism for regulation of neuronal excitability by endogenous toxin–like molecules. PMID:20010822

  12. International Trade Union Seminar on Active Manpower Policy, (Vienna, September 17-20, 1963). Final Report. International Seminars 1963-1.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France). Social Affairs Div.

    This seminar provided for exchange of current experiences and views on active manpower policy by management and trade unionists in the member countries of the Organization for Economic Cooperation and Development. The present volume consists of a report of the proceedings, the conclusions reached by the participants, and reprints of the three…

  13. A Case Report of Supplement-Induced Hepatitis in an Active Duty Service Member.

    PubMed

    Brazeau, Michael J; Castaneda, Joni L; Huitron, Sonny S; Wang, James

    2015-07-01

    The incidence of drug-induced hepatic injury has been increasing as a result of more widespread use of workout supplements containing anabolic steroids to increase muscle mass. Synthetic androgenic steroids are shown to cause cholestatic liver injury, but the exact mechanism of injury is not completely understood. We present a case of a healthy, young, active duty Army male soldier who developed pruritis and jaundice shortly after starting to take a body-building supplement containing anabolic steroids, and was subsequently found to have significant biopsy proven drug-induced liver injury. PMID:26126259

  14. A new tropical active serpentinization end-member discovered in Costa Rica

    NASA Astrophysics Data System (ADS)

    Sanchez-Murillo, R.; Gazel, E.; Boll, J.; Schwarzenbach, E. M.

    2013-12-01

    Serpentinization is a planetary process where ultramafic rocks react with fluids with important consequences on global biogeochemical cycles through formation of H2 and CH4. Exposed sections of upper-mantle rocks on continents, where meteoric water interacts with the ultramafic rocks, provide natural laboratories to study present-day serpentinization. Here, we present geochemical evidence of active serpentinization and methane vents in the Santa Elena Ophiolite (comprising 250 km2 of ultramafic rocks) in Costa Rica. The system is sustained by peridotites with a 50% degree of serpentinization. Two alkaline spring systems were discovered. The alkaline fluids pH ranged from 11.01 to 11.18. Mean hydroxide and carbonate concentrations were 52 mg/L and 38 mg/L. Mean dissolved calcium was 104 mg/L with a maximum of 167 mg/L. These springs are also characterized by low Mg (< 1 mg/L) and K (2.35 mg/L) and relatively high Na (21.4 mg/L) and chloride (27.1 mg/L) concentrations. Average spring temperature was 29.1°C. Active CH4 vents (24.3% volume) coupled with extensive carbonate deposits (magnesite and calcite with isotopic compositions within the range of similar ultramafic hosted systems) also provide strong evidence of active serpentinization. Groundwater and alkaline spring's hydrological connectivity was explored using stable isotope as natural tracers. Isotope composition of the alkaline fluids (d18O = -7.9‰, d2H = -51.4‰) was remarkably similar to the groundwater signature from 10 deep wells (30-70 m) (d18O = -7.6‰; dD = -48.0‰) sampled in local watersheds. These results support the hypothesis that during prolonged dry periods these alkaline springs are fed by deep subsurface storage. Mean electrical conductivity of the alkaline fluids (622 uS/cm) was considerably higher than of surface waters (470 uS/cm); this significant difference may be additional evidence of active serpentinization in the area. Overall, Santa Elena's varying weather conditions between

  15. An event history analysis of union joining and leaving.

    PubMed

    Buttigieg, Donna M; Deery, Stephen J; Iverson, Roderick D

    2007-05-01

    This article examines parallel models of union joining and leaving using individual-level longitudinal panel data collected over a 5-year period. The authors utilized objective measures of joining and leaving collected from union and organizational records and took into account time by using event history analysis. The results indicated that union joining was negatively related to procedural justice and higher performance appraisals and positively related to partner socialization and extrinsic union instrumentality. Conversely, members were most likely to leave the union when they perceived lower procedural justice, where there was no union representative present in the workplace, and where they had individualistic orientations. The authors discuss the implications of these findings for theory and practice for trade unions. PMID:17484562

  16. "We Are in This Together": Common Group Identity Predicts Majority Members' Active Acculturation Efforts to Integrate Immigrants.

    PubMed

    Kunst, Jonas R; Thomsen, Lotte; Sam, David L; Berry, John W

    2015-10-01

    Although integration involves a process of mutual accommodation, the role of majority groups is often downplayed to passive tolerance, leaving immigrants with the sole responsibility for active integration. However, we show that common group identity can actively involve majority members in this process across five studies. Study 1 showed that common identity positively predicted support of integration efforts; Studies 2 and 3 extended these findings, showing that it also predicted real behavior such as monetary donations and volunteering. A decrease in modern racism mediated the relations across these studies, and Studies 4 and 5 further demonstrated that it indeed mediated these effects over and above acculturation expectations and color-blindness, which somewhat compromised integration efforts. Moreover, the last two studies also demonstrated that common, but not dual, groups motivated integration efforts. Common identity appears crucial for securing majorities' altruistic efforts to integrate immigrants and, thus, for achieving functional multiculturalism. PMID:26276500

  17. 12 CFR 708a.3 - Board of directors' approval and members' opportunity to comment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Board of directors' approval and members... REGULATIONS AFFECTING CREDIT UNIONS CONVERSION OF INSURED CREDIT UNIONS TO MUTUAL SAVINGS BANKS § 708a.3 Board of directors' approval and members' opportunity to comment. (a) A credit union's board of...

  18. 78 FR 77608 - Requirements for Contacts with Federal Credit Unions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... ADMINISTRATION 12 CFR Part 701 RIN 3133-AE34 Requirements for Contacts with Federal Credit Unions AGENCY...) proposes to amend part 701 of its regulations to require examinations and other contacts between NCUA staff... one method for members and NCUA staff to contact the credit union. These requirements would apply...

  19. Think Tank Report. Communicating How Unions Contribute to Community.

    ERIC Educational Resources Information Center

    ACU-I Bulletin, 1991

    1991-01-01

    This report presents viewpoints and arguments made during a meeting of higher education administrators who were assembled to discuss ways that Associations of College Unions-International (ACU-I) and its members can communicate the union's mission as campus community builder. The overall focus of the meeting comes from the Carnegie Foundation's…

  20. An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities.

    PubMed

    Moss, Marcia L; Minond, Dmitriy; Yoneyama, Toshie; Hansen, Hinrich P; Vujanovic, Nikola; Rasmussen, Fred H

    2016-08-15

    A fluorescent resonance energy transfer substrate with improved sensitivity for ADAM17, -10, and -9 (where ADAM represents a disintegrin and metalloproteinase) has been designed. The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (±0.3) × 10(4) M(-1) s(-1) and 2.4 (±0.3) × 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively. The substrate is more sensitive than widely used peptides based on the precursor tumor necrosis factor-alpha (TNF-alpha) cleavage site, PEPDAB010 or Dabcyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Lys(FAM)-NH2 and Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Arg-NH2. ADAM9 also processes the new peptide more than 18-fold better than the TNF-alpha-based substrates. The new substrate has a unique selectivity profile because it is processed less efficiently by ADAM8 and MMP1, -2, -3, -8, -9, -12, and -14. This substrate provides a unique tool in which to assess ADAM17, -10, and -9 activities. PMID:27177841

  1. Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer.

    PubMed

    Palla, A R; Piazzolla, D; Abad, M; Li, H; Dominguez, O; Schonthaler, H B; Wagner, E F; Serrano, M

    2014-05-01

    NANOG is a key transcription factor for pluripotency in embryonic stem cells. The analysis of NANOG in human cells is confounded by the presence of multiple and highly similar paralogs. In particular, there are three paralogs encoding full-length proteins, namely, NANOG1, NANOG2 and NANOGP8, and at least eight additional paralogs that do not encode full-length NANOG proteins. Here, we have examined NANOG family expression in human embryonic stem cells (hESCs) and in human cancer cell lines using a multi-NANOG PCR that amplifies the three functional paralogs and most of the non-functional ones. As anticipated, we found that hESCs express large amounts of NANOG1 and, interestingly, they also express NANOG2. In contrast, most human cancer cells tested express NANOGP8 and the non-coding paralogs NANOGP4 and NANOGP5. Notably, in some cancer cell lines, the NANOG protein levels produced by NANOGP8 are comparable to those produced by NANOG1 in pluripotent cells. Finally, we show that NANOGP8 is as active as NANOG1 in the reprogramming of human and murine fibroblasts into induced pluripotent stem cells. These results show that cancer-associated NANOGP8 can contribute to promote de-differentiation and/or cellular plasticity. PMID:23752184

  2. A Palladium-Catalyzed Carbonylation Approach to Eight-Membered Lactam Derivatives with Antitumor Activity.

    PubMed

    Mancuso, Raffaella; Raut, Dnyaneshwar S; Marino, Nadia; De Luca, Giorgio; Giordano, Cinzia; Catalano, Stefania; Barone, Ines; Andò, Sebastiano; Gabriele, Bartolo

    2016-02-24

    The reactivity of 2-(2-alkynylphenoxy)anilines under PdI2 /KI-catalyzed oxidative carbonylation conditions has been studied. Although a different reaction pathway could have been operating, N-palladation followed by CO insertion was the favored pathway with all substrates tested, including those containing an internal or terminal triple bond. This led to the formation of a carbamoylpalladium species, the fate of which, as predicted by theoretical calculations, strongly depended on the nature of the substituent on the triple bond. In particular, 8-endo-dig cyclization preferentially occurred when the triple bond was terminal, leading to the formation of carbonylated ζ-lactam derivatives, the structures of which have been confirmed by XRD analysis. These novel medium-sized heterocyclic compounds showed antitumor activity against both estrogen receptor-positive (MCF-7) and triple negative (MDA-MB-231) breast cancer cell lines. In particular, ζ-lactam 3 j' may represent a novel and promising antitumor agent because biological tests clearly demonstrate that this compound significantly reduces cell viability and motility in both MCF-7 and MDA-MB-231 breast cancer cell lines, without affecting normal breast epithelial cell viability. PMID:26821986

  3. Teacher Union Bargaining: Practice and Policy.

    ERIC Educational Resources Information Center

    Geisert, Gene; Lieberman, Myron

    This book provides school board members with hands-on guidelines for collaborative bargaining with teacher unions. The book combines the practical with the conceptual and policy dimensions of teacher bargaining. Part 1 provides a view of immediate problems in their context--broad policy issues that affect across-the-table bargaining. Eight…

  4. 75 FR 75648 - Corporate Credit Unions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... Board issued a proposed rule amending its corporate credit union rule. 75 FR 73000 (November 29, 2010... is not also a member. 75 FR 73000 (November 29, 2010). NCUA requested comments on its proposal and... From the Federal Register Online via the Government Publishing Office NATIONAL CREDIT...

  5. Unions Assail Teacher Ideas in NCLB Draft

    ERIC Educational Resources Information Center

    Klein, Alyson; Hoff, David J.

    2007-01-01

    This article reports on two national teachers' unions that have mounted a vigorous lobbying campaign to rewrite language linking teacher bonuses to student test scores and other incentive-pay provisions contained in a draft bill for reauthorizing the No Child Left Behind Act. Members of the National Education Association circulated in the halls of…

  6. Universal Services in the European Union.

    ERIC Educational Resources Information Center

    Bauer, Johannes M.

    1999-01-01

    Discusses universal service policies in the European Union. Topics include information access; the demise of the public service model; the effects of competition on universal service; financing; national implementation of member states; programs for schools and libraries; and pertinent Web sites on European universal service policy. (LRW)

  7. Multi-Union Efforts in New York

    ERIC Educational Resources Information Center

    Newfield, Marcia

    2008-01-01

    The Professional Staff Congress (PSC), the union for twenty-two thousand faculty and staff members at the City University of New York (CUNY), has been successful at gaining New York State aid for tuition remission for doctoral students and health insurance for graduate student employees, increasing budget allotments to CUNY, and obtaining transit…

  8. [Decisions of the Party and the tasks of the All-Union Society of Pathologicoanatomists].

    PubMed

    Paukov, V S

    1980-01-01

    The ways and forms of work of the All-Union and regional scientific societies of pathology in realization of the CPSU CC Degree "On Further Improvement of Ideological and Political Education Work" are discussed. It is suggested that the entire activity of the pathology societies be directed at the solution of the two main objectives extensive development and perfection of methodology of research work and direct participation of the pathology societies in the educational work among their members. PMID:7447751

  9. Administration and Operation of the College Union. Third Edition. College Unions at Work Monograph Series, Number 1.

    ERIC Educational Resources Information Center

    Miller, Marlis R.; Galey, Denise

    Administrative and operational patterns of college student unions were studied in 1986. Questionnaires were returned by 504 out of 928 members of the Association of College Unions-International in the United States, Canada, Australia, New Zealand, and Japan. A total of 88 statistical tables and narrative summaries of findings are provided. The…

  10. Neck and shoulder muscle activity and posture among helicopter pilots and crew-members during military helicopter flight.

    PubMed

    Murray, Mike; Lange, Britt; Chreiteh, Shadi Samir; Olsen, Henrik Baare; Nørnberg, Bo Riebeling; Boyle, Eleanor; Søgaard, Karen; Sjøgaard, Gisela

    2016-04-01

    Neck pain among helicopter pilots and crew-members is common. This study quantified the physical workload on neck and shoulder muscles using electromyography (EMG) measures during helicopter flight. Nine standardized sorties were performed, encompassing: cruising from location A to location B (AB) and performing search and rescue (SAR). SAR was performed with Night Vision Goggles (NVG), while AB was performed with (AB+NVG) and without NVG (AB-NVG). EMG was recorded for: trapezius (TRA), upper neck extensors (UNE), and sternocleido-mastoid (SCM). Maximal voluntary contractions (MVC) were performed for normalization of EMG (MVE). Neck posture of pilots and crew-members was monitored and pain intensity of neck, shoulder, and back was recorded. Mean muscle activity for UNE was ∼10% MVE and significantly higher than TRA and SCM, and SCM was significantly lower than TRA. There was no significant difference between AB-NVG and AB+NVG. Muscle activity in the UNE was significantly higher during SAR+NVG than AB-NVG. Sortie time (%) with non-neutral neck posture for SAR+NVG and AB-NVG was: 80.4%, 74.5% (flexed), 55.5%, 47.9% (rotated), 4.5%, 3.7% (lateral flexed). Neck pain intensity increased significantly from pre- (0.7±1.3) to post-sortie (1.6±1.9) for pilots (p=0.028). If sustained, UNE activity of ∼10% MVE is high, and implies a risk for neck disorders. PMID:26852114

  11. Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation

    PubMed Central

    Brauchle, Michael; Yao, Zhiping; Arora, Rishi; Thigale, Sachin; Clay, Ieuan; Inverardi, Bruno; Fletcher, Joy; Taslimi, Paul; Acker, Michael G.; Gerrits, Bertran; Voshol, Johannes; Bauer, Andreas; Schübeler, Dirk; Bouwmeester, Tewis; Ruffner, Heinz

    2013-01-01

    Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC domain-containing proteins are one class of broadly expressed enzymes catalyzing methyl group removal. However, several JmjC proteins remain uncharacterized, gaps persist in understanding substrate recognition, and the integration of JmjC proteins into signaling pathways is just emerging. The KDM3 subfamily is an evolutionarily conserved group of histone demethylase proteins, thought to share lysine substrate specificity. Here we use a systematic approach to compare KDM3 subfamily members. We show that full-length KDM3A and KDM3B are H3K9me1/2 histone demethylases whereas we fail to observe histone demethylase activity for JMJD1C using immunocytochemical and biochemical approaches. Structure-function analyses revealed the importance of a single amino acid in KDM3A implicated in the catalytic activity towards H3K9me1/2 that is not conserved in JMJD1C. Moreover, we use quantitative proteomic analyses to identify subsets of the interactomes of the 3 proteins. Specific interactor candidates were identified for each of the three KDM3 subfamily members. Importantly, we find that SCAI, a known transcriptional repressor, interacts specifically with KDM3B. Taken together, we identify substantial differences in the biology of KDM3 histone demethylases, namely enzymatic activity and protein-protein interactions. Such comparative approaches pave the way to a better understanding of histone demethylase specificity and protein function at a systems level and are instrumental in identifying the more subtle differences between closely related proteins. PMID:23593242

  12. Analysis of promoter activity of members of the PECTATE LYASE-LIKE (PLL) gene family in cell separation in Arabidopsis

    PubMed Central

    2010-01-01

    Background Pectate lyases depolymerize pectins by catalyzing the eliminative cleavage of α-1,4-linked galacturonic acid. Pectate lyase-like (PLL) genes make up among the largest and most complex families in plants, but their cellular and organismal roles have not been well characterized, and the activity of these genes has been assessed only at the level of entire organs or plant parts, potentially obscuring important sub-organ or cell-type-specific activities. As a first step to understand the potential functional diversity of PLL genes in plants and specificity of individual genes, we utilized a reporter gene approach to document the spatial and temporal promoter activity for 23 of the 26 members of the Arabidopsis thaliana (Arabidopsis) PLL gene family throughout development, focusing on processes involving cell separation. Results Numerous PLL promoters directed activity in localized domains programmed for cell separation, such as the abscission zones of the sepal, petal, stamen, and seed, as well as the fruit dehiscence zone. Several drove activity in cell types expected to facilitate separation, including the style and root endodermal and cortical layers during lateral root emergence. However, PLL promoters were active in domains not obviously programmed for separation, including the stipule, hydathode and root axis. Nearly all PLL promoters showed extensive overlap of activity in most of the regions analyzed. Conclusions Our results document potential for involvement of PLL genes in numerous aspects of growth and development both dependent and independent of cell separation. Although the complexity of the PLL gene family allows for enormous potential for gene specialization through spatial or temporal regulation, the high degree of overlap of activity among the PLL promoters suggests extensive redundancy. Alternatively, functional specialization might be determined at the post-transcriptional or protein level. PMID:20649977

  13. Dissolution of bedded rock salt: A seismic profile across the active eastern margin of the Hutchinson Salt Member, central Kansas

    USGS Publications Warehouse

    Anderson, N.L.; Hopkins, J.; Martinez, A.; Knapp, R.W.; Macfarlane, P.A.; Watney, W.L.; Black, R.

    1994-01-01

    Since late Tertiary, bedded rock salt of the Permian Hutchinson Salt Member has been dissolved more-or-less continuously along its active eastern margin in central Kansas as a result of sustained contact with unconfined, undersaturated groundwater. The associated westward migration of the eastern margin has resulted in surface subsidence and the contemporaneous sedimentation of predominantly valley-filling Quarternary alluvium. In places, these alluvium deposits extend more than 25 km to the east of the present-day edge of the main body of contiguous rock salt. The margin could have receded this distance during the past several million years. From an environmental perspective, the continued leaching of the Hutchinson Salt is a major concern. This predominantly natural dissolution occurs in a broad zone across the central part of the State and adversely affects groundwater and surface-water quality as nonpoint source pollution. Significant surface subsidence occurs as well. Most of these subsidence features have formed gradually; others developed in a more catastrophic manner. The latter in particular pose real threats to roadways, railways, and buried oil and gas pipelines. In an effort to further clarify the process of natural salt dissolution in central Kansas and with the long-term goal of mitigating the adverse environmental affects of such leaching, the Kansas Geological Survey acquired a 4-km seismic profile across the eastern margin of the Hutchinson Salt in the Punkin Center area of central Kansas. The interpretation of these seismic data (and supporting surficial and borehole geologic control) is consistent with several hypotheses regarding the process and mechanisms of dissolution. More specifically these data support the theses that: 1. (1) Dissolution along the active eastern margin of the Hutchinson Salt Member was initiated during late Tertiary. Leaching has resulted in the steady westward migration of the eastern margin, surface subsidence, and the

  14. Activity in M Dwarf Members of NGC 2516 and M67: Calibrating an Age-Activity Relation

    NASA Astrophysics Data System (ADS)

    Andersen, Jan M.; West, A. A.; Covey, K. R.; McDonald, M.; Veilleux, S.; Seth, A.

    2011-05-01

    We present preliminary results from a study of M dwarf magnetic activity in clusters of known ages with the ultimate goal of constraining the age-activity relation. The age-activity relation provides clues to the mechanisms generating magnetic dynamos, especially in late-type dwarfs where their stellar interiors become fully convective. Broadband griz photometry was obtained for four clusters with ages ranging from 150 Myrs to 4 Gyrs. Narrowband images of each cluster were acquired with the Maryland Magellan Tunable Filter, tuned to the frequency of H-alpha (including a correction for each cluster's radial velocity) and a nearby, similarly sized bandpass sampling the stellar pseudo-continuum. This permits a "photometric” measurement of the H-alpha emission for each star, and thus a measure of activity. Cluster membership is determined from broadband photometry and comparison to stellar positions from previous studies. We report on our findings for the clusters NGC 2516 and M67. H-alpha measurements are stronger for cluster stars than for field stars of the same magnitude. In NGC 2516, a clear correlation is seen between our H-alpha strengths measured by narrowband imaging and previous spectroscopic activity measurements in stars for which spectra have been obtained. J.M.A. acknowledges support through an NSF Graduate Research Fellowship.

  15. What Can Trade Unions Do To Combat Child Labour?

    ERIC Educational Resources Information Center

    Myrstad, Geir

    1999-01-01

    Examines mainly practical activities of trade unions to fight child labor. Argues that trade unions can give the most significant contribution to the struggle against child labor by focusing on methods that are typical for, or even exclusive to, the trade union movement, in particular negotiations and collective bargaining. (Author)

  16. Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma

    PubMed Central

    Guadagno, J; Xu, X; Karajgikar, M; Brown, A; Cregan, S P

    2013-01-01

    Neuroinflammation is a common feature of acute neurological conditions such as stroke and spinal cord injury, as well as neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Previous studies have demonstrated that acute neuroinflammation can adversely affect the survival of neural precursor cells (NPCs) and thereby limit the capacity for regeneration and repair. However, the mechanisms by which neuroinflammatory processes induce NPC death remain unclear. Microglia are key mediators of neuroinflammation and when activated to induce a pro-inflammatory state produce a number of factors that could affect NPC survival. Importantly, in the present study we demonstrate that tumor necrosis factor α (TNFα) produced by lipopolysaccharide-activated microglia is necessary and sufficient to trigger apoptosis in mouse NPCs in vitro. Furthermore, we demonstrate that microglia-derived TNFα induces NPC apoptosis via a mitochondrial pathway regulated by the Bcl-2 family protein Bax. BH3-only proteins are known to play a key role in regulating Bax activation and we demonstrate that microglia-derived TNFα induces the expression of the BH3-only family member Puma in NPCs via an NF-κB-dependent mechanism. Specifically, we show that NF-κB is activated in NPCs treated with conditioned media from activated microglia and that Puma induction and NPC apoptosis is blocked by the NF-κB inhibitor BAY-117082. Importantly, we have determined that NPC apoptosis induced by activated microglia-derived TNFα is attenuated in Puma-deficient NPCs, indicating that Puma induction is required for NPC death. Consistent with this, we demonstrate that Puma-deficient NPCs exhibit an ∼13-fold increase in survival as compared with wild-type NPCs following transplantation into the inflammatory environment of the injured spinal cord in vivo. In summary, we have identified a key signaling pathway that regulates neuroinflammation induced apoptosis

  17. Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma.

    PubMed

    Guadagno, J; Xu, X; Karajgikar, M; Brown, A; Cregan, S P

    2013-01-01

    Neuroinflammation is a common feature of acute neurological conditions such as stroke and spinal cord injury, as well as neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Previous studies have demonstrated that acute neuroinflammation can adversely affect the survival of neural precursor cells (NPCs) and thereby limit the capacity for regeneration and repair. However, the mechanisms by which neuroinflammatory processes induce NPC death remain unclear. Microglia are key mediators of neuroinflammation and when activated to induce a pro-inflammatory state produce a number of factors that could affect NPC survival. Importantly, in the present study we demonstrate that tumor necrosis factor α (TNFα) produced by lipopolysaccharide-activated microglia is necessary and sufficient to trigger apoptosis in mouse NPCs in vitro. Furthermore, we demonstrate that microglia-derived TNFα induces NPC apoptosis via a mitochondrial pathway regulated by the Bcl-2 family protein Bax. BH3-only proteins are known to play a key role in regulating Bax activation and we demonstrate that microglia-derived TNFα induces the expression of the BH3-only family member Puma in NPCs via an NF-κB-dependent mechanism. Specifically, we show that NF-κB is activated in NPCs treated with conditioned media from activated microglia and that Puma induction and NPC apoptosis is blocked by the NF-κB inhibitor BAY-117082. Importantly, we have determined that NPC apoptosis induced by activated microglia-derived TNFα is attenuated in Puma-deficient NPCs, indicating that Puma induction is required for NPC death. Consistent with this, we demonstrate that Puma-deficient NPCs exhibit an ∼13-fold increase in survival as compared with wild-type NPCs following transplantation into the inflammatory environment of the injured spinal cord in vivo. In summary, we have identified a key signaling pathway that regulates neuroinflammation induced apoptosis

  18. Taphonomy and paleoecology of nonmarine mollusca: indicators of alluvial plain lacustrine sedimentation, upper part of the Tongue River Member, Fort Union Formation ( Paleocene), Northern Powder River Basin, Wyoming and Montana ( USA).

    USGS Publications Warehouse

    Hanley, J.H.; Flores, R.M.

    1987-01-01

    The composition, species abundances, and spatial and temporal distributions of mollusc assemblages were controlled by the environments in which they lived and the depositional processes that affected the molluscs after death and before final burial. Post-mortem transport, reworking and concentration of shells, and mixing of faunal elements from discrete habitats produced a taphonomic 'overprint' on assemblage characteristics that directly reflects the processes of alluvial plain and floodbasin lacustrine sedimentation. The 'overprint' can be interpreted from outcrop analysis of molluscan biofabric, which consists of: 1) orientation, fragmentation, size-sorting, abrasion, density, and dispersion of shells, 2) the nature and extent of shell-infilling, and 3) ratio of articulated to disarticulated bivalves. Taphonomic characteristics were used with sedimentological properties to differentiate in-place, reworked, transported, and ecologically mixed mollusc assemblages. This study also defines the paleoecology of habitat preferences of mollusc species as a basis for recognition of the environments in which these assemblages were deposited: 1) large floodbasin lakes, 2) small floodbasin lakes, and 3) crevasse deltas and splays. Integration of sedimentology and paleoecology provides an interdisciplinary approach to the interpretation of alluvial environments through time in the Tongue River Member. -Authors

  19. New 15-membered tetraaza (N4) macrocyclic ligand and its transition metal complexes: Spectral, magnetic, thermal and anticancer activity

    NASA Astrophysics Data System (ADS)

    El-Boraey, Hanaa A.; EL-Gammal, Ohyla A.

    2015-03-01

    Novel tetraamidemacrocyclic 15-membered ligand [L] i.e. naphthyl-dibenzo[1,5,9,12]tetraazacyclopentadecine-6,10,11,15-tetraoneand its transition metal complexes with Fe(II), Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On the basis of analytical, spectral (IR, MS, UV-Vis, 1H NMR and EPR) and thermal studies distorted octahedral or square planar geometry has been proposed for the complexes. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50 = 2.27-2.7, 8.33-31.1 μg/mL, respectively) showed potent antitumor activity, towards the former cell lines comparable with their ligand (IC50 = 13, 26 μg/mL, respectively). The results show that the activity of the ligand towards breast cancer cell line becomes more pronounced and significant when coordinated to the metal ion.

  20. Member of the CREB/ATF protein family, but not CREB alpha plays an active role in BLV tax trans activation in vivo.

    PubMed Central

    Kiss-Toth, E; Paca-uccaralertkun, S; Unk, I; Boros, I

    1993-01-01

    The trans activator protein of Bovine Leukaemia Virus (tax) increases the rate of transcription from the virus promoter through 21 bp sequences located in three tandem copies in the virus LTR. Based on data obtained by three different experimental approaches we concluded that the central CRE-like motif found in each of the BLV 21 bp repeats plays an important and indispensable role in tax mediated trans activation. These include (i) in vivo analysis of the function of mutant 21 bp sequences in transient transfection, (ii) gel mobility shift assay to show that CREB binds to BLV 21 bp repeats in vitro and (iii) the demonstration that the production of antisense CREB mRNA inhibits tax trans activation. Further studies with different deletion mutant CREB proteins suggest that although CREB alpha can interact with factors involved in BLV trans activation, it does not promote transcription initiation; consequently some other member/s of the CREB/ATF family must be involved. Images PMID:8396235

  1. Dues and Deep Pockets: Public-Sector Unions' Money Machine. Civic Report. No. 67

    ERIC Educational Resources Information Center

    DiSalvo, Daniel

    2012-01-01

    At first glance, public-sector labor unions are just one of many types of organizations that participate in the political process. However, these unions differ significantly from other interest groups made up of individual citizens or non-labor organizations. Because their members' interests are tied to government policy, these unions are more…

  2. Teachers' Unions and the Politics of Education in Japan. SUNY Series on Japan in Transition.

    ERIC Educational Resources Information Center

    Aspinall, Robert W.

    In 1989, the Japan Teachers' Union, Nikkyoso, split into two unions after 2 years of factional infighting. Japan has two political camps, the governing conservative Liberal Democratic Party and the left-wing Japan Socialist Party. The teachers' union is a powerful member in the camp of the latter. This book incorporates studies of the links…

  3. Interchanges: Solidarity Forever--Why TA Unions Are Good for Writing Programs

    ERIC Educational Resources Information Center

    Bernard-Donals, Michael

    2009-01-01

    In this essay, the author explains how teaching assistant (TA) unions work to the benefit not only of the graduate students who are their members but also of the writing programs that employ them. While university administrations understand unions to be bothersome at best and forces of evil at their worst, unions are essential to the maintenance…

  4. NEA/AFT Membership: The Critical Issues. EPI Series on Teacher Unions.

    ERIC Educational Resources Information Center

    Haar, Charlene K.; Lieberman, Myron

    This booklet, one in the Education Policy Institute series about teacher union issues, examines issues related to membership in the National Education Association (NEA) and American Federation of Teachers (AFT). Both unions aggressively strive to enroll more members or require teachers to pay agency fees. If teachers want to change union policy,…

  5. Art of Disaster Preparedness in European Union: a Survey on the Health Systems

    PubMed Central

    Djalali, Ahmadreza; Della Corte, Francesco; Foletti, Marco; Ragazzoni, Luca; Ripoll Gallardo, Alba; Lupescu, Olivera; Arculeo, Chris; von Arnim, Götz; Friedl, Tom; Ashkenazi, Michael; Fischer, Philipp; Hreckovski, Boris; Khorram-Manesh, Amir; Komadina, Radko; Lechner, Konstanze; Patru, Cristina; Burkle, Frederick M.; Ingrassia, Pier Luigi

    2014-01-01

    Introduction: Naturally occurring and man-made disasters have been increasing in the world, including Europe, over the past several decades. Health systems are a key part of any community disaster management system. The success of preparedness and prevention depends on the success of activities such as disaster planning, organization and training. The aim of this study is to evaluate health system preparedness for disasters in the 27 European Union member countries. Method: A cross-sectional analysis study was completed between June-September 2012. The checklist used for this survey was a modified from the World Health Organization toolkit for assessing health-system capacity for crisis management. Three specialists from each of the 27 European Union countries were included in the survey. Responses to each survey question were scored and the range of preparedness level was defined as 0-100%, categorized in three levels as follows: Acceptable; Transitional; or Insufficient. Results: Response rate was 79.1%. The average level of disaster management preparedness in the health systems of 27 European Union member states was 68% (Acceptable). The highest level of preparedness was seen in the United Kingdom, Luxemburg, and Lithuania. Considering the elements of disaster management system, the highest level of preparedness score was at health information elements (86%), and the lowest level was for hospitals, and educational elements (54%). Conclusion: This survey study suggests that preparedness level of European Union countries in 2012 is at an acceptable level but could be improved. Elements such as hospitals and education and training suffer from insufficient levels of preparedness. The European Union health systems need a collective strategic plan, as well as enough resources, to establish a comprehensive and standardized disaster management strategy plan. A competency based training curriculum for managers and first responders is basic to accomplishing this goal

  6. [Unionization on Campus].

    ERIC Educational Resources Information Center

    Douglas, Joel M., Ed.

    1982-01-01

    This newsletter issue considers in separate articles: (1) unionization in 1981 among college faculty in the United States; (2) unionization at the California State University and College System (CSU) (by Lisa Flanzraich); (3) multi-year agreements; (4) contract size; (5) and, in "Yeshivawatch," developments pertaining to the National Labor…

  7. Today's Associations, Tomorrow's Unions.

    ERIC Educational Resources Information Center

    Ichniowski, Casey; Zax, Jeffrey S.

    1990-01-01

    Analysis of census data on local government departments investigated the effects of association-style unionism on union membership. Found that in all local government services, the presence of an association in 1977 was a strong predictor of the formation of a bargaining unit by 1982--holding constant other important determinants of public…

  8. Unions, Contractors and CTE

    ERIC Educational Resources Information Center

    Jarosz, Francesca

    2006-01-01

    Across Illinois, in places where unions thrive, construction industry professionals and career and technical education (CTE) teachers are working together in promoting work-based learning program to students. Likewise, the outreach program provides union-supported contractors with qualified candidates for future employment. Programs such as the…

  9. Sustainability in the Union

    ERIC Educational Resources Information Center

    Brown, Patrick; Taylor, John

    2012-01-01

    Operating as the center of student life, college unions have a central role to teach citizenship, social responsibility, and leadership. Unions can serve as locations for education and conversations about sustainability, as well as for organizations operationally and programmatically engaged in sustainable practices. In this chapter, the authors…

  10. Teacher Unions 101

    ERIC Educational Resources Information Center

    Koppich, Julia E.

    2012-01-01

    Teacher unions are hard to miss in the news lately. Newspapers, blogs, social media posts, magazine articles, and political speeches abound with talk of them. Teacher unions are a hot topic and one that probably was not covered in college classes. The noisy back-and-forth among partisans can be both mind-numbing and confusing, often creating a…

  11. Unionism and Professionalism: Siblings?

    ERIC Educational Resources Information Center

    Loewenthal, Alfred; Nielsen, Robert

    The controversy surrounding the meaning of professionalism on American campuses is approached by examining the subject from an historical and trade union perspective. It is contended that faculty unions are compatible with professional needs and desires of faculty. The roots of the American college and university system are examined in conjunction…

  12. Cholestatic liver injury associated with dietary supplements: a report of five cases in active duty service members.

    PubMed

    Peterson, Brandon R; DeRoche, Tom C; Huber, Aaron R; Shields, William W

    2013-10-01

    The use of dietary supplements (DS) is common in the active duty population, often without physician knowledge or approval. DS have been associated with drug-induced liver injury, with rare cases resulting in liver failure or death. We report five cases of transient drug-induced liver injury temporally associated with the use of a total of six DS in active duty service members. All patients presented with elevated serum bilirubin and liver-associated enzymes: three patients had a cholestatic liver enzyme pattern, one had a hepatocellular pattern, and one had a mixed pattern. In all cases, percutaneous needle core biopsies of the liver were obtained and demonstrated a cholestatic pattern of injury with variable periportal fibrosis. Causality was considered highly probable for three cases, probable for one case, and possible for one case. Hepatotoxicity has been previously associated with four of the supplements in our cases. For the two remaining supplements, C4 Extreme and Animal Stak, we are unaware of any previous reports of hepatotoxicity. Health care professionals, in particular military physicians, should be aware of the potential risk of these supplements and be prepared to discuss these risks with their patients. PMID:24083935

  13. Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection.

    PubMed

    Barillas-Mury, C; Han, Y S; Seeley, D; Kafatos, F C

    1999-02-15

    A new insect member of the STAT family of transcription factors (Ag-STAT) has been cloned from the human malaria vector Anopheles gambiae. The domain involved in DNA interaction and the SH2 domain are well conserved. Ag-STAT is most similar to Drosophila D-STAT and to vertebrate STATs 5 and 6, constituting a proposed ancient class A of the STAT family. The mRNA is expressed at all developmental stages, and the protein is present in hemocytes, pericardial cells, midgut, skeletal muscle and fat body cells. There is no evidence of transcriptional activation following bacterial challenge. However, bacterial challenge results in nuclear translocation of Ag-STAT protein in fat body cells and induction of DNA-binding activity that recognizes a STAT target site. In vitro treatment with pervanadate (vanadate and H2O2) translocates Ag-STAT to the nucleus in midgut epithelial cells. This is the first evidence of direct participation of the STAT pathway in immune responses in insects. PMID:10022838

  14. Transactions of the International Astronomical Union, Volume XIXB: Proceedings of the Nineteenth General Assembly, Delhi 1985.

    NASA Astrophysics Data System (ADS)

    Swings, J.-P.

    The XIXth General Assembly of the IAU was held in New Delhi, India, from November 19 to 28, 1985. This volume summarizes the work of the XIXth General Assembly. The discourses given during the Inaugural Ceremony, held at Siri Fort Auditorium, are reproduced. The proceedings of the two sessions of the General Assembly on November 19 and 28, 1985 are given, as well as the Resolutions and other aspects of the administration of the Union: they provide the official recordof the business of the General Assembly, and, together with the Executive Committee report, constitute the permanent record for the Union in the period 1982 - 1985. In addition, this volume contains the Commission Reports from Delhi, compiled by the Presidents of the Commissions. Pending re-edition of a complete Astronomer's Handbook, which is in preparation, some information about a few activities of the Union, as well as its Statutes and By laws are given. Finally, the chapter "Membership" contains the list of countries adhering to the Union, member lists of IAU Commissions, and also an alphabetical list of the more than 6000 individual members of the IAU (with addresses, phone and telex numbers, affiliation to commission(s)).

  15. Elastomeric member

    DOEpatents

    Hoppie, Lyle O.

    1985-01-01

    An energy storage device (10) is disclosed consisting of a stretched elongated elastomeric member (16) disposed within a tubular housing (14), which elastomeric member (16) is adapted to be torsionally stressed to store energy. The elastomeric member (16) is configured in the relaxed state with a uniform diameter body section (74), and transition end sections (76, 78), attached to rigid end piece assemblies (22, 24) of a lesser diameter. The profile and deflection characteristic of the transition sections (76, 78) are such that upon stretching of the elastomeric member (16), a substantially uniform diameter assembly results, to minimize the required volume of the surrounding housing (14). Each of the transition sections (76, 78) are received within and bonded to a woven wire mesh sleeve (26, 28) having helical windings at a particular helix angle to control the deflection of the transition section. Each sleeve (26, 28) also contracts with the contraction of the associated transition section to maintain the bond therebetween. During manufacture, the sleeves (26, 28) are forced against a forming surface and bonded to the associated transition section (76, 78) to provide the correct profile and helix angle.

  16. Elastomeric member

    DOEpatents

    Hoppie, L.O.

    1985-07-30

    An energy storage device is disclosed consisting of a stretched elongated elastomeric member disposed within a tubular housing, which elastomeric member is adapted to be torsionally stressed to store energy. The elastomeric member is configured in the relaxed state with a uniform diameter body section, and transition end sections, attached to rigid end piece assemblies of a lesser diameter. The profile and deflection characteristic of the transition sections are such that upon stretching of the elastomeric member, a substantially uniform diameter assembly results, to minimize the required volume of the surrounding housing. Each of the transition sections are received within and bonded to a woven wire mesh sleeve having helical windings at a particular helix angle to control the deflection of the transition section. Each sleeve also contracts with the contraction of the associated transition section to maintain the bond there between. During manufacture, the sleeves are forced against a forming surface and bonded to the associated transition section to provide the correct profile and helix angle. 12 figs.

  17. Education Efforts of the International Astronomical Union

    NASA Astrophysics Data System (ADS)

    Pasachoff, J. M.

    2006-08-01

    I describe the education activities of the International Astronomical Union, particularly the work of Commission 46 on Education and Development. We are most interested in education in schools and for general university education rather than for pre-professional training or graduate schools. We have over 75 National Liaisons, mostly from member countries of the I.A.U. but some from nonmembers or regional groupings. We operate through 10 program groups, which are described at our Website at http://www.astronomyeducation.org. We also organize Special Sessions at General Assemblies of the International Astronomical Union, such as this Special Session 2 on Innovation in Teaching/ Learning Astronomy Methods, organized by Rosa Ros and me, and Special Session 5 on Astronomy for the Developing World, organized by John Hearnshaw. A modified version of our Special Session from the 2003 Sydney General Assembly was published as Teaching and Learning Astronomy: Effective Strategies for Educators Worldwide (Jay M. Pasachoff and John R. Percy, eds., Cambridge University Press, 2005). Michele Gerbaldi and Ed Guinan run the International Schools for Young Astronomers. Jay White heads the Teaching Astronomy for Development Program Group. John Hearnshaw runs the Program Group for the Worldwide Development of Astronomy. Charles Tolbert and John Percy run an Exchange of Astronomers program with a limited number of grants for stays of over three months between astronomers in developing countries and established astronomical institutions. Barrie Jones, as vice-president, aided by Tracey Moore, runs the Newsletter and keeps track of the National Liaisons list. I run the Program group of Public Education at the Times of Solar Eclipses.

  18. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender.

    PubMed

    Bolling, Danielle Z; Pelphrey, Kevin A; Vander Wyk, Brent C

    2016-10-01

    The effects of group membership on brain responses to social exclusion have been investigated in adults, revealing greater anterior cingulate responses to exclusion by members of one's in-group (e.g., same-gender). However, social exclusion is a critical aspect of peer relations in youth and reaches heightened salience during adolescence, a time when social anxiety disorders are also emergent. While the behavioral and neural correlates of social exclusion in adolescence have been extensively explored, the effects of group membership on peer rejection are less clear. The current study used functional magnetic resonance imaging (fMRI) to investigate the differential neural correlates of being excluded by peers of one's same- versus opposite-gender during an online ball-toss game. Participants were a group of typically developing children and adolescents (7-17 years). As predicted, anterior cingulate cortex showed a main effect of social exclusion versus fair play. However, unlike a previous adult study, this region did not show increased activation to same-gender exclusion. Instead, several regions differentiating same- versus opposite-gender exclusion were exclusively more sensitive to exclusion by one's opposite gender. These results are discussed in the context of adolescent socio-emotional development. PMID:26592311

  19. Achilles tendon ruptures stratified by age, race, and cause of injury among active duty U.S. Military members.

    PubMed

    Davis, J J; Mason, K T; Clark, D A

    1999-12-01

    A total of 865 members of the U.S. military underwent repair of Achilles tendon ruptures at U.S. military hospitals during calendar years 1994, 1995, and 1996. The discharge summaries of these patients were analyzed for patient demographic information, including age, race, and causative activity. Patients were then stratified by age, race, and cause of injury. Blacks were at increased risk for undergoing repair of the Achilles tendon compared with nonblacks (overall relative risk = 4.15, 95% confidence interval [CI] = 3.63, 4.74; summary odds ratio controlling for age = 3.69, CI = 3.25, 4.19). Participation in the game of basketball accounted for 64.9% of all injuries in black patients and 34.0% of all injuries in nonblack patients. Among those injured, blacks had a significantly increased risk for injury related to playing basketball than nonblacks (relative risk = 1.82, CI = 1.58, 2.10). This finding suggests that there may be other predisposing factor(s) that result in a higher risk of Achilles tendon ruptures in black individuals. PMID:10628159

  20. 78 FR 4875 - Office of Small Credit Unions (OSCUI) Loan Program Access for Credit Unions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... November 2, 2011. 76 FR 67583. Additional requirements are found at 12 CFR Parts 701 and 741. Applicants... credit union's marketing strategy to reach members and the community; and include financial projections... its strategy for raising matching funds if NCUA determines matching funds are required (see 12...

  1. 75 FR 81378 - Fiduciary Duties at Federal Credit Unions; Mergers and Conversions of Insured Credit Unions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... fundamental rights of credit union members, and makes conforming changes to the standard FCU and corporate... Proposal) to amend parts 701, 708a, and 708b of NCUA's rules. 75 FR 15574 (March 29, 2010). The Proposal... promulgated by the Federal Housing Finance Agency (FHFA). 12 CFR 917.2(b)(1). Some commenters stated that...

  2. Supporting members

    NASA Astrophysics Data System (ADS)

    Life Supporting Members L. Thomas Aldrich Thomas D. Barrow Hugh J . A. Chivers Allan V. Cox Samuel S. Goldich Pembroke J. Hart A. Ivan Johnson Helmut E. Landsberg Paolo Lanzano Murli H. Manghnani L. L. Nettleton Charles B. Officer Hyman Orlin Ned A. Ostenso Erick O. Schonstedt Waldo E. Smith Athelstan Spilhaus A. F. Spilhaus, Jr. John W. Townsend, Jr. James A. Van Allen Leonard W. Weis Charles A. Whitten J. Tuzo Wilson

  3. Analysis of the active site mechanism of Tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily

    PubMed Central

    Gajewski, Stefan; Comeaux, Evan Q.; Jafari, Nauzanene; Bharatham, Nagakumar; Bashford, Donald; White, Stephen W.; van Waardenburg, Robert C.A.M.

    2011-01-01

    Tyrosyl DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily and hydrolyzes 3′phospho-DNA adducts via two conserved catalytic histidines, one acting as the lead nucleophile and the second as a general acid/base. Substitution of the second histidine specifically to arginine contributes to the neurodegenerative disease SCAN1. We investigated the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crystallography, biochemistry, yeast genetics and theoretical chemistry. The structures of wild type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn. The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts access of a nucleophilic water molecule to the Tdp1-DNA intermediate. Biochemical analyses confirm that His432Arg forms an observable and unique Tdp1-DNA adduct during catalysis. Substitution of His432 by Lys does not affect catalytic activity or yeast phenotype, but substitution with Asn, Gln, Leu, Ala, Ser and Thr all result in severely compromised enzymes and Top1-camptothecin dependent lethality. Surprisingly, His432Asn did not show a stable covalent Tdp1-DNA intermediate which suggests another catalytic defect. Theoretical calculations revealed that the defect resides in the nucleophilic histidine and that the pKa of this histidine is crucially dependent upon the second histidine and the incoming phosphate of the substrate. This represents a unique example of substrate-activated catalysis that applies to the entire phospholipase D superfamily. PMID:22155078

  4. Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily

    SciTech Connect

    Gajewski, Stefan; Comeaux, Evan Q.; Jafari, Nauzanene; Bharatham, Nagakumar; Bashford, Donald; White, Stephen W.; van Waardenburg, Robert C.A.M.

    2012-03-15

    Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of the phospholipase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines - one acting as the lead nucleophile and the second acting as a general acid/base. Substitution of the second histidine specifically to arginine contributes to the neurodegenerative disease spinocerebellar ataxia with axonal neuropathy (SCAN1). We investigated the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crystallography, biochemistry, yeast genetics, and theoretical chemistry. The structures of wild-type Tdp1 and His432Arg both show a phosphorylated form of the nucleophilic histidine that is not observed in the structure of His432Asn. The phosphohistidine is stabilized in the His432Arg structure by the guanidinium group that also restricts the access of nucleophilic water molecule to the Tdp1-DNA intermediate. Biochemical analyses confirm that His432Arg forms an observable and unique Tdp1-DNA adduct during catalysis. Substitution of His432 by Lys does not affect catalytic activity or yeast phenotype, but substitutions with Asn, Gln, Leu, Ala, Ser, and Thr all result in severely compromised enzymes and DNA topoisomerase I-camptothecin dependent lethality. Surprisingly, His432Asn did not show a stable covalent Tdp1-DNA intermediate that suggests another catalytic defect. Theoretical calculations revealed that the defect resides in the nucleophilic histidine and that the pK{sub a} of this histidine is crucially dependent on the second histidine and on the incoming phosphate of the substrate. This represents a unique example of substrate-activated catalysis that applies to the entire phospholipase D superfamily.

  5. 22 CFR 124.16 - Special retransfer authorizations for unclassified technical data and defense services to member...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... unclassified technical data and defense services to member states of NATO and the European Union, Australia... NATO and the European Union, Australia, Japan, New Zealand, and Switzerland. The provisions of § 124.8... countries that are members of NATO the European Union, Australia, Japan, New Zealand, and Switzerland...

  6. Technology and the Unions.

    ERIC Educational Resources Information Center

    Monaghan, Peter

    1995-01-01

    Faculty union meetings will focus increasingly on the role of technology on college campuses, including adoption of new technologies, assuring support services, clarifying intellectual property issues, and preserving teacher-student contact as teleconferencing and network use grows. (MSE)

  7. Competences for Learning to Learn and Active Citizenship: Different Currencies or Two Sides of the Same Coin?

    ERIC Educational Resources Information Center

    Hoskins, Bryony; Crick, Ruth Deakin

    2010-01-01

    In the context of the European Union Framework of Key Competences and the need to develop indicators for European Union member states to measure progress made towards the "knowledge economy" and "greater social cohesion" both the learning to learn and the active citizenship competences have been highlighted. However, what have yet to be discussed…

  8. 45 CFR 2520.50 - How much time may AmeriCorps members in my program spend in education and training activities?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false How much time may AmeriCorps members in my program spend in education and training activities? 2520.50 Section 2520.50 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS § 2520.50...

  9. 45 CFR 2520.50 - How much time may AmeriCorps members in my program spend in education and training activities?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false How much time may AmeriCorps members in my program spend in education and training activities? 2520.50 Section 2520.50 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GENERAL PROVISIONS: AMERICORPS SUBTITLE C PROGRAMS § 2520.50...

  10. Characterization of active members in C and N cycles in the subsurface environment of the Witwatersrand Basin

    NASA Astrophysics Data System (ADS)

    Lindsay, M. R.; Lau, C. M.; Tetteh, G.; Snyder, L.; Kieft, T. L.; Lollar, B. S.; Li, L.; Maphanga, S.; van Heerden, E.; Onstott, T. C.

    2012-12-01

    methanotrophs were found three times more than Type I methanotrophs. A pmoA gene sequence represents 42% of the library matches only and is identical to a putative protein sequence annotated on Ca. D. audaxviator genome, but further analysis is required to validate its candidature of methanotrophy. The cluster of mcrA gene sequences is related to a novel group of anaerobic methanotrophs (ANME) defined by environmental sequences. 2011 July samples from the same borehole revealed an absence of Firmicutes. Two β-Proteobacterial sequences dominated the bacterial 16S rDNA clone library, accounting for 54% and 25%. The first 16S rRNA clone library for the region confirmed a complete lack of Firmicutes with active Proteobacteria (71% α-, 17% β- and 6% γ-Proteobacteria). Only 3% of the active community is confidently inferred as methylotrophs while 22% belongs to N2 fixer Rhizobium sp. which has been demonstrated to stimulate methanotrophic growth and 28% is related to Polymorphum gilvum, which is known for n-alkane degradation. Active members responsible for CH4 metabolism will be supported by presenting the results of archaeal 16S rRNA, pmoA, mcrA and nitrogenase gene diversities. The lack of Firmicutes in July samples could be attributed to collection methods: different filter membrane, faster flowrate but shorter sampling duration, and less total volume of water filtered.

  11. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi.

    PubMed

    Wong, Tania A; Fairn, Gregory D; Poon, Pak P; Shmulevitz, Maya; McMaster, Christopher R; Singer, Richard A; Johnston, Gerald C

    2005-09-01

    The budding yeast Saccharomyces cerevisiae contains a family of Arf (ADP-ribosylation factor) GTPase activating protein (GAP) proteins with the Gcs1 + Age2 ArfGAP pair providing essential overlapping function for the movement of transport vesicles from the trans-Golgi network. We have generated a temperature-sensitive but stable version of the Gcs1 protein that is impaired only for trans-Golgi transport and find that deleterious effects of this enfeebled Gcs1-4 mutant protein are relieved by increased gene dosage of the gcs1-4 mutant gene itself or by the SFH2 gene (also called CSR1), encoding a phosphatidylinositol transfer protein (PITP). This effect was not seen for the SEC14 gene, encoding the founding member of the yeast PITP protein family, even though the Gcs1 and Age2 ArfGAPs are known to be downstream effectors of Sec14-mediated activity for trans-Golgi transport. Sfh2-mediated suppression of inadequate Gcs1-4 function depended on phospholipase D, whereas inadequate Gcs1-4 activity was relieved by increasing levels of diacylglycerol (DAG). Recombinant Gcs1 protein was found to bind certain phospholipids but not DAG. Our findings favor a model of Gcs1 localization through binding to specific phospholipids and activation of ArfGAP activity by DAG-mediated membrane curvature as the transport vesicle is formed. Thus, ArfGAPs are subject to both temporal and spatial regulation that is facilitated by Sfh2-mediated modulation of the lipid environment. PMID:16126894

  12. Recent and Hazardous Volcanic Activity Along the NW Rift Zone of Piton De La Fournaise Volcano, La Réunion Island

    NASA Astrophysics Data System (ADS)

    Walther, G.; Frese, I.; Di Muro, A.; Kueppers, U.; Michon, L.; Metrich, N.

    2014-12-01

    Shield volcanoes are a common feature of basaltic volcanism. Their volcanic activity is often confined to a summit crater area and rift systems, both characterized by constructive (scoria and cinder cones; lava flows) and destructive (pit craters; caldera collapse) phenomena. Piton de la Fournaise (PdF) shield volcano (La Réunion Island, Indian Ocean) is an ideal place to study these differences in eruptive behaviour. Besides the frequent eruptions in the central Enclos Fouqué caldera, hundreds of eruptive vents opened along three main rift zones cutting the edifice during the last 50 kyrs. Two short rift zones are characterized by weak seismicity and lateral magma transport at shallow depth (above sea level). Here we focus on the third and largest rift zone (15km wide, 20 km long), which extends in a north-westerly direction between PdF and nearby Piton des Neiges volcanic complex. It is typified by deep seismicity (up to 30 km), emitting mostly primitive magmas, testifying of high fluid pressures (up to 5 kbar) and large-volume eruptions. We present new field data (including stratigraphic logs, a geological map of the area, C-14 dating and geochemical analyses of the eruption products) on one of the youngest (~6kyrs) and largest lava field (Trous Blancs eruption). It extends for 24km from a height of 1800 m asl, passing Le Tampon and Saint Pierre cities, until reaching the coast. The source area of this huge lava flow has been identified in an alignment of four previously unidentified pit craters. The eruption initiated with intense fountaining activity, producing a m-thick bed of loose black scoria, which becomes densely welded in its upper part; followed by an alternation of volume rich lava effusions and strombolian activity, resulting in the emplacement of meter-thick, massive units of olivine-basalt alternating with coarse scoria beds in the proximal area. Activity ended with the emplacement of a dm-thick bed of glassy, dense scoria and a stratified lithic

  13. 12 CFR 708a.3 - Board of directors' approval and members' opportunity to comment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Board of directors' approval and members' opportunity to comment. 708a.3 Section 708a.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS BANK CONVERSIONS AND MERGERS Conversion of Insured Credit Unions to Mutual Savings Banks § 708a.3 Board of...

  14. 12 CFR 708b.106 - Approval of the merger proposal by members.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Approval of the merger proposal by members. 708b.106 Section 708b.106 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MERGERS OF FEDERALLY-INSURED CREDIT UNIONS; VOLUNTARY TERMINATION OR CONVERSION OF INSURED STATUS Mergers § 708b.106 Approval of...

  15. "Obey", "disobey" or "tinker with" reforms to the system: a subject for French teacher trade unions to work on.

    PubMed

    Cau-Bareille, Dominique

    2012-01-01

    This paper presents our work to support and train members of the teaching sectors of two trade unions. The aim was to encourage participants to discuss practices, the difficulties in their day-to-day work and impediments to taking action, given the current reforms to primary education, and thereby assess the reforms' impact on the teachers' activity. It was also intended to help trade unions build up a collective dynamic around their work and re-positioning the work activity at the heart of their preoccupations. This project consisted of one/two day workshops held at local trade union branches. They were led by an ergonomist and a trade union representative. The discussions revealed that the prescriptions received from the management increasingly contradict the values of the profession. Therefore, in the name of professional ethics, different strategies of resistance have emerged, from minor modifications to the prescriptions received, to disobedience. However, adopting such strategies is itself a cause of suffering for teaching staff, and leads to some leaving the profession prematurely. We will discuss the difficulty trade unions have in dealing with the issue of work, their strategic positioning as regards developments within the profession, and the role an ergonomist can play in this process. PMID:22317528

  16. The Individual Member and the Future.

    ERIC Educational Resources Information Center

    Adams, Jenny; And Others

    1987-01-01

    The needs and expectations of members of the Library Association of Australia are explored in four articles. Highlights include fee requirements, lobbying by the association, the inclusion of information professionals in the membership, the possible role of trade unions, and the distribution of women in leadership positions. (CLB)

  17. Jonathan Rosen: building a dynamic union-based health and safety program.

    PubMed

    Rosen, Jonathan; McLaughlin, Kaci; Slatin, Craig

    2014-01-01

    Jonathan Rosen has spent more than 30 years building union-based health and safety programs. In the 1970s he was a union activist. In 1980 he became a union health and safety committee chair at a Milwaukee manufacturing firm. Following that, he had a nearly 20-year career with the New York State Public Employees Federation (PEF). He trained as an industrial hygienist and developed a highly regarded public sector union-based health and safety program. PEF's Health and Safety Department supported a network of union health and safety committees. Program accomplishments included innovative work on workplace violence prevention, indoor environmental quality, infectious diseases, and ergonomics. Mr. Rosen promoted collaboration among unions, helped support new activists, advocated tirelessly for injured workers, and formed an effective alliance with researchers. Rosen discusses essential strategies for mobilizing union members and gaining commitment to health and safety from unions, employers, and policy makers. PMID:25053608

  18. Please Help Your Union

    NASA Astrophysics Data System (ADS)

    Killeen, Tim

    2006-03-01

    The continuing success of AGU relies entirely on the volunteer work of members. A major contribution to these efforts comes from the over 40 committees that plan, oversee, and have operational roles in our meetings, publications, finances, elections, awards, education, public information, and public affairs activities. The names of committees are provided in the accompanying text box; their current membership and descriptions can be found on the Web at the AGU site. One of the most important and challenging tasks of the incoming AGU President is to reestablish these committees by appointing hundreds of volunteers. I now solicit your help in staffing these committees. Ideally, participation in these important committees will reflect the overall membership and perspectives of AGU members, so please do consider volunteering yourself. Of course, nominations of others would also be very welcome. I am particularly interested in making sure that the gender balance, age, and geographic representation are appropriate and reflect our changing demographics. Any suggestions you might have will be more helpful if accompanied by a few sentences of background information relevant to the particular committee.

  19. Economic Demise of the Soviet Union.

    ERIC Educational Resources Information Center

    Foundation for Teaching Economics, San Francisco, CA.

    This series of lesson plans and activities deals with the economic demise of the now-defunct Soviet Union. Each of the five lessons and six activities addresses identified standards and benchmarks from the Voluntary National Content Standards in Economics. The lesson plans also address the National History Content Standards, in terms of both the…

  20. Public health sector unions and deregulation in Europe.

    PubMed

    Lethbridge, Jane

    2004-01-01

    Deregulation and liberalization of health services take several forms in Europe: public-private partnerships; contracting out of services; and corporatization of health care institutions. The impact on health workers includes changes in terms and conditions of employment, breakup of collective bargaining agreements, and often more stressful working conditions. The author examines four types of trade union responses to deregulation. National health trade union action has used campaigning, awareness raising, and judicial review. Health workers' unions in alliance with other trade unions have taken part in wider campaigns against privatization and in promoting public services. Health workers' unions joining with social movements have become involved in wider alliances that link with broader public policy issues such as poverty reduction and urban/regional regeneration. European-wide action, seen through the work of the European Federation of Public Service Unions, has concentrated on the development of an alternative health policy, and the promotion of social dialogue at a European level. Trade unions must adopt a range of approaches to challenge the effects of deregulation. Increasingly, trade union members need to be aware of how to take action at both the national and European levels. PMID:15346679

  1. Unions and Workplace Reorganization.

    ERIC Educational Resources Information Center

    Nissen, Bruce, Ed.

    The 11 chapters in this book focus on "The New American Workplace" and assess its adequacy or inadequacy as a guide for the U.S. labor movement in relation to new work systems. "Unions and Workplace Reorganization" (Bruce Nissen) introduces the subject. "The New American Workplace: A Labor Perspective" (AFL-CIO Committee on the Evolution of Work,…

  2. Unionism and American Education.

    ERIC Educational Resources Information Center

    Spring, Joel

    Organized labor in the United States has been divided in the types of economic solutions it has sought for the working class and in the type of support it has given education. In terms of education, rightwing unionism has tended to accept the basic structure of American education and the general ideology of equality of opportunity. Leftwing…

  3. Faculty Unionism and Tenure

    ERIC Educational Resources Information Center

    McHugh, William F.

    1973-01-01

    With reference to personal experience, labor board decisions, and faculty collective bargaining agreements, the author discusses the causes of faculty unionism, what constitutes a tenure system and what problems it creates, what is involved in the bargaining process, and the implications involved in negotiating tenure. (JT)

  4. Trade Union Rights.

    ERIC Educational Resources Information Center

    Maier, Heribert; And Others

    1994-01-01

    Excerpts addresses from an international symposium regarding workers' education, human rights, labor standards and law, socioeconomic factors, trade unions, workers' rights, professionalism, and globalization. Includes a background paper, "Participation of Workers and Their Organizations in the Field of International Labour Standards and the…

  5. Unions, Solidarity, and Striking

    ERIC Educational Resources Information Center

    Dixon, Marc; Roscigno, Vincent J.; Hodson, Randy

    2004-01-01

    Organizational resources and group solidarity are central foci in literature on social movements generally and worker insurgency specifically. Research, however, seldom deals with both simultaneously and their potential interrelations. In this article, we examine the complex relationships between union organization and worker solidarity relative…

  6. Teacher Unions and Parent Involvement. EPI Series on Teacher Unions.

    ERIC Educational Resources Information Center

    Haar, Charlene K.

    This booklet, part of the Education Policy Institute series about teacher union issues, clarifies the concept of parent involvement in educational reform, analyzing the treatment of parents in collective bargaining contracts between teacher unions and school boards and in union policy resolutions. Chapter 1 introduces the issue, offering an…

  7. New Roles for Teachers Unions? Reform Unionism in School Decentralization

    ERIC Educational Resources Information Center

    Donaldson, Morgaen L.; Mayer, Anysia P.; Cobb, Casey D.; LeChasseur, Kimberly; Welton, Anjale

    2013-01-01

    Of late, teachers unions have worked together with district management in new and notable ways. This paper examines the role of teachers unions in shaping the Together Initiative (TI), which seeks to increase autonomy and broaden decision making in urban schools in one northeastern state. In general, state-level union leaders have taken more…

  8. The Australian Education Union and Teacher Union Modernization.

    ERIC Educational Resources Information Center

    Spaull, Andrew

    1998-01-01

    Examines some of the directions that modernization of teacher unionism has taken in the 1990s, explaining that the 1990s has been the decade of the Australian Education Union (AEU). The paper describes the AEU and looks at organizational changes within the AEU, industrial roles, and political roles that affect today's teacher unions in Australia.…

  9. 12 CFR 716.5 - Annual privacy notice to members required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Annual privacy notice to members required. 716.5 Section 716.5 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS PRIVACY OF CONSUMER FINANCIAL INFORMATION Privacy and Opt Out Notices § 716.5 Annual privacy notice to members required. (a)(1) General...

  10. Midwifery and the enlarged European Union.

    PubMed

    Mead, Marianne

    2003-06-01

    The freedom of movement of midwives within the European Union has been guaranteed by the application of midwives' sectoral directives signed in 1980 and applied in 1983. Since then the size of the European Union has grown from 9 to 15 members and is due for a next wave of enlargement of another 10 member states in 2004. The rules and regulations that govern the European Union are being revisited to accommodate this change. Midwifery will be affected and some changes are potentially worrying, in particular the proposed loss of the Advisory Committee on the Training of Midwives. Six other professions regulated in a very similar way are also to lose their own advisory committees. The European Commission has proposed the adoption of a single directive for all professions, together with the setting up of an expert group whose function would be to deal principally with health professions. However, neither its remit nor its membership has been determined. Whereas previous movement of midwives within Europe has been minimal, it is anticipated that this may well be changed at the next enlargement stage. Without clear directives and some form of controlling power at European level, public health may be threatened. In this paper the developments to date and the concerns that have emerged from the recent proposals are outlined. PMID:12809627

  11. Mechanistic and Bioinformatic Investigation of a Conserved Active Site Helix in α-Isopropylmalate Synthase from Mycobacterium tuberculosis, a Member of the DRE-TIM Metallolyase Superfamily

    PubMed Central

    2015-01-01

    The characterization of functionally diverse enzyme superfamilies provides the opportunity to identify evolutionarily conserved catalytic strategies, as well as amino acid substitutions responsible for the evolution of new functions or specificities. Isopropylmalate synthase (IPMS) belongs to the DRE-TIM metallolyase superfamily. Members of this superfamily share common active site elements, including a conserved active site helix and an HXH divalent metal binding motif, associated with stabilization of a common enolate anion intermediate. These common elements are overlaid by variations in active site architecture resulting in the evolution of a diverse set of reactions that include condensation, lyase/aldolase, and carboxyl transfer activities. Here, using IPMS, an integrated biochemical and bioinformatics approach has been utilized to investigate the catalytic role of residues on an active site helix that is conserved across the superfamily. The construction of a sequence similarity network for the DRE-TIM metallolyase superfamily allows for the biochemical results obtained with IPMS variants to be compared across superfamily members and within other condensation-catalyzing enzymes related to IPMS. A comparison of our results with previous biochemical data indicates an active site arginine residue (R80 in IPMS) is strictly required for activity across the superfamily, suggesting that it plays a key role in catalysis, most likely through enolate stabilization. In contrast, differential results obtained from substitution of the C-terminal residue of the helix (Q84 in IPMS) suggest that this residue plays a role in reaction specificity within the superfamily. PMID:24720347

  12. 26 CFR 31.3401(a)(1)-1 - Remuneration of members of the Armed Forces of the United States for active service in combat...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Remuneration of members of the Armed Forces of the United States for active service in combat zone or while hospitalized as a result of such service. 31.3401(a)(1)-1 Section 31.3401(a)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) EMPLOYMENT TAXES...

  13. Racial Discrimination and Trade Unionism

    ERIC Educational Resources Information Center

    Ashenfelter, Orley

    1972-01-01

    Analyzes the likely determinants of a trade union's policy regarding race and estimates the effect of the presence of unionism on the average wage of black workers relative to that of white workers under various types of union organizational structure. (RJ)

  14. What's Wrong with Teacher Unions.

    ERIC Educational Resources Information Center

    Urban, Wayne J.

    1998-01-01

    Responds and takes exception to the assumptions and arguments of Myron Lieberman, who argues against teacher unionism and says it is the major obstacle to educational reform. After summarizing Lieberman's discussion of contemporary teacher unions, concludes that Lieberman is biased against teacher unions in his analysis of their contemporary…

  15. Repartnering after First Union Disruption

    ERIC Educational Resources Information Center

    Wu, Zheng; Schimmele, Christoph M.

    2005-01-01

    Using data from the 1995 General Social Survey (N= 2,639), this study examines two competing repartnering choices made by Canadians after first union disruption: marriage or cohabitation. About 42% of women and 54% of men form a second union 5 years after union disruption, with cohabitation being the most prevalent choice. The timing of second…

  16. PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.

    PubMed

    Lee, Yong Hoi; Pang, Siew Wai; Tan, Kuan Onn

    2016-04-22

    PNMA2, a member of the Paraneoplastic Ma Family (PNMA), was identified through expression cloning by using anti-sera from patients with paraneoplastic disorder. Tissue expression studies showed that PNMA2 was predominantly expressed in normal human brain; however, the protein was shown to exhibit abnormal expression profile as it was found to be expressed in a number of tumour tissues obtained from paraneopalstic patients. The abnormal expression profile of PNMA2 suggests that it might play an important role in tumorigenesis; however, apart from protein expression and immunological studies, the physiological role of PNMA2 remains unclear. In order to determine potential role of PNMA2 in tumorigenesis, and its functional relationship with PNMA family members, MOAP-1 (PNMA4) and PNMA1, expression constructs encoding the respective proteins were generated for both in vitro and in vivo studies. Our investigations showed that over-expressed MOAP-1 and PNMA1 promoted apoptosis and chemo-sensitization in MCF-7 cells as evidenced by condensed nuclei and Annexin-V positive MCF-7 cells; however, the effects mediated by these proteins were significantly inhibited or abolished when co-expressed with PNMA2 in MCF-7 cells. Furthermore, co-immunoprecipitation study showed that PNMA1 and MOAP-1 failed to associate with each other but readily formed respective heterodimer with PNMA2, suggesting that PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction. PMID:27003254

  17. New modes of regulation for health and safety: post-enlargement policy perspectives for the European Union.

    PubMed

    Woolfson, Charles

    2006-01-01

    The recent joining of ten new member states to the European Union, eight of which are former communist countries, has reopened inherent tensions in current European Union (EU) policy-making on safety and health in the workplace. These spring from seemingly incompatible objectives; the need to ensure broad EU member state compliance with regulation, around agreed minimum standards through active regulatory enforcement, and the promotion of "softer" voluntary initiatives in the management of workplace risks and hazards in order to create "a culture of prevention." The present EU strategy which ends in 2006, seeks to secure a balance between both sets of objectives. However, with respect to the post-communist new member states of Central and Eastern Europe, the appropriateness of the current strategy is doubtful. This article therefore focuses on the implications of the expansion of the European Union in May 2004 in the context of the elaboration of the new "soft law" modes of regulatory governance at the EU level. In turn, this provokes the question: will the "new" European policy for occupational health and safety from 2007 onwards, be "new," or simply more of the same? If the latter, it is suggested that the future for working environment standards in Europe as a whole may be significantly compromised. PMID:16943136

  18. Union Learning Representatives: Facilitating Professional Development for Scottish Teachers

    ERIC Educational Resources Information Center

    Alexandrou, Alex; O'Brien, Jim

    2007-01-01

    In the United Kingdom, teachers' professional associations and labor organizations, notably in the form of trade unions have historically been involved in education and training in the workplace. Recently, in the United Kingdom this activity has gained greater credence and importance due to the emergence of trade union learning representatives who…

  19. Modernised Learning: An Emerging Lifelong Agenda by British Trade Unions?

    ERIC Educational Resources Information Center

    Forrester, Keith P.

    2001-01-01

    British trade unions' engagement in workplace learning is currently shaped by discourses of globalization and the learning society. Unions' workplace learning representatives appear more focused on uncritical acceptance of learning for employability and less on learning for active citizenship and workplace democracy. (Contains 21 references.) (SK)

  20. The Content and Functions of Labor Education in the Soviet Union.

    ERIC Educational Resources Information Center

    Boyle, George V.

    Labor unions in the U.S.S.R.--having emerged in Russia about 100 years after U.S. labor unions and been called by Lenin the "shock troops of the revolution"--do not much resemble their U.S. counterparts. Union members, including factory managers, constitute 99.3 percent of the work force, and place of employment or profession determines which of…

  1. Minorities and Women in Apprenticeship Programs and Referral Unions. Equal Employment Opportunity Report--1978.

    ERIC Educational Resources Information Center

    Equal Employment Opportunity Commission, Washington, DC.

    In 1978, there were almost 150,000 apprentices in the United States; 4 percent were women and 19 percent were members of minority groups. At the same time, there were more than two million union members in this country; 11 percent were women and 24 percent were members of minorities, according to the 1978 Equal Employment Opportunities Commission…

  2. Protection of Space-based observations and the International Telecommunication Union (ITU)

    NASA Astrophysics Data System (ADS)

    Ohishi, Masatoshi

    International Telecommunication Union (ITU) is the organization to discuss and establish protection criteria and measures for the space-based observations. The measures are described in the Radio Regulations (RR), that has a status of the international treaty. ITU holds the World Radiocommunication Conference (WRC) every 3-4 years, and the latest one, WRC-2007, established the protection measure for the Radioastron. In the discussion on this issue, the IUCAF and its members played important role, however, only a few people who are familiar with the space-based radio astronomy observations participated in the discussion. It is highly desirable for the space-based radio astronomy researchers to participate in the ITU activity through IUCAF where COSPAR has the official representatives. I will review the ITU structure and the results of WRC-2007 for the COSPAR members to understand the IUCAF and ITU activities.

  3. Regulatory pathways in the European Union.

    PubMed

    Kohler, Manuela

    2011-01-01

    In principle, there are three defined procedures to obtain approval for a medicinal product in the European Union. As discussed in this overview of the procedures, the decision on which regulatory pathway to use will depend on the nature of the active substance, the target indication(s), the history of product and/or the marketing strategy. PMID:21487236

  4. Aiming for Giants: Charter School Legislation and the Power of Teacher Unions

    ERIC Educational Resources Information Center

    Giersch, Jason

    2014-01-01

    Historically, strong teacher unions have been successful at gaining benefits and security for their members, but they have been put on the defensive by recent proposals for education reform. Charter schools are one such reform that could threaten unions, but there is wide variety in the content of state charter school laws. Using state-level data…

  5. Limits on Union-Backed Political Speech: "Ysura v. Pocatello Education Association"

    ERIC Educational Resources Information Center

    Russo, Charles J.

    2009-01-01

    Free speech concerns associated with collective bargaining become important when unions impose fair-share fees that charge nonmembers for costs associated with the benefits they receive through labor negotiations. When unions collect fair-share fees, those payments often support causes with which nonmembers and dissenting members disagree.…

  6. State of the Union touches on science

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    With the Senate impeachment trial as a backdrop, U.S. President Bill Clinton delivered a State of the Union address on January 19 that included a number of items related to science policy.Calling the threat of global warming “our most fateful new challenge,” the President proposed a package of climate change initiatives to help communities reduce greenhouse and other pollution, and tax incentives and investments to spur clean energy technology. He also offered to work with members of Congress in both parties to reward companies that take early, voluntary action to reduce greenhouse gases.

  7. Recycling policy in the european union

    NASA Astrophysics Data System (ADS)

    Gaballah, I.; Kanari, N.

    2001-11-01

    Recycling in the European Union (EU) has benefited from R&D efforts and strict environmental regulations of the EU’s members. Thanks to the adoption of sustainable development policies by the EU’s European Institutions, economic incentives are expected to further strengthen the recycling industry. Moreover, the historical accumulation of non-ferrous metals in Europe will likely enhance secondary metal production. Also contributing to EU recycling is mining in East European countries and the resulting industrial waste. The rate of growth of the recycling industry is expected to approach double digits for at least this decade.

  8. Impact of Transcendental Meditation on Psychotropic Medication Use Among Active Duty Military Service Members With Anxiety and PTSD.

    PubMed

    Barnes, Vernon A; Monto, Andrea; Williams, Jennifer J; Rigg, John L

    2016-01-01

    The purpose of the study was to determine whether the regular practice of Transcendental Meditation (TM) decreased the need for psychotropic medications required for anxiety and post-traumatic stress disorder (PTSD) management and increased psychological wellbeing. The sample included 74 military Service Members with documented PTSD or anxiety disorder not otherwise specified (ADNOS), 37 that practiced TM and 37 that did not. At 1 month, 83.7% of the TM group stabilized, decreased, or ceased medications and 10.8% increased medication dosage; compared with 59.4% of controls that showed stabilizations, decreases, or cessations; and 40.5% that increased medications (p < 0.03). A similar pattern was observed after 2 (p < 0.27), 3 (p < 0.002), and 6 months (p < 0.34). Notably, there was a 20.5% difference between groups in severity of psychological symptoms after 6 months, that is, the control group experienced an increase in symptom severity compared with the group practicing TM. These findings provide insight into the benefits of TM as a viable treatment modality in military treatment facilities for reducing PTSD and ADNOS psychological symptoms and associated medication use. PMID:26741477

  9. Gender, Jobs and Working Conditions in the European Union.

    ERIC Educational Resources Information Center

    Fagan, Colette; Burchell, Brendan

    Trends in gender, jobs, and working conditions in the European Union (EU) were examined. In 2000, representative samples of approximately 1,500 workers in each of the EU member states (500 in Luxembourg) were surveyed. To identify trends, the survey findings were compared with those of similar surveys conducted in 1991 and 1996. The comparison…

  10. 12 CFR 705.7 - Loans to participating credit unions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... amount. However, any loan monies matched by member share deposits will be credited as a two-for-one match... available to the participating credit union only after it has documented that it has met the match... generate the required match within one year of the approval of the loan will result in the reduction of...

  11. Worker-Centered Learning: A Union Guide to Basic Skills.

    ERIC Educational Resources Information Center

    American Federation of Labor and Congress of Industrial Organizations, Washington, DC. Working for America Inst.

    This guide is designed to be used by union leaders wishing to increase the basic skills (the full array of reading, writing, communication, math, reasoning, and problem-solving skills) of their members by running a workplace learning program. It provides guidelines for analyzing the needs of the target group of workers and for developing an…

  12. Reforming Educational Reform: Teachers' Union Leading Teacher Research in Chile

    ERIC Educational Resources Information Center

    Montecinos, Carmen

    2009-01-01

    The teacher research movement in Chile has, historically, been an expression of the profession's concerns with the ways in which schooling reproduces and produces the social order in the broader society. The work currently done by members of the union's Pedagogical Movement is described, showing the connections between the scope of problems…

  13. Conducting an Introductory Biology Course in an Active Learning Classroom: A Case Study of an Experienced Faculty Member

    ERIC Educational Resources Information Center

    Langley, David; Guzey, S. Selcen

    2014-01-01

    A case study is described that examines the beliefs and practices of a university instructor who teaches regularly in an active learning classroom. His perspective provides insights into the pedagogical practices that drive his success in these learning spaces.

  14. Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity.

    PubMed

    Lerner-Marmarosh, Nicole; Shen, Jenny; Torno, Michael D; Kravets, Anatoliy; Hu, Zhenbo; Maines, Mahin D

    2005-05-17

    We describe here the tyrosine kinase activity of human biliverdin reductase (BVR) and its potential role in the insulin-signaling pathway. BVR is both a substrate for insulin receptor (IR) tyrosine kinase (IRK) activity and a kinase for serine phosphorylation of IR substrate 1 (IRS-1). Our previous studies have revealed serine/threonine kinase activity of BVR. Y198, in the YMKM motif found in the C-terminal domain of BVR, is shown to be a substrate for insulin-activated IRK. This motif in IRS proteins provides a docking site for proteins that contain a Src homology 2 domain. Additionally, Y228 in the YLSF sequence and Y291 are IRK substrates; the former sequence provides optimum recognition motif in the tyrosine phosphatase, SHP-1, and for SHC (Src homology 2 domain containing transfroming protein 1). BVR autophosphorylates N-terminal tyrosines Y72 and Y83. Serine residues in IRS-1 are targets for BVR phosphorylation, and point mutation of serine residues in the kinase domain of the reductase inhibits phosphotransferase activity. Because tyrosine phosphorylation of IRS-1 activates the insulin signaling pathway and serine phosphorylation of IRS-1 blocks insulin action, our findings that insulin increases BVR tyrosine phosphorylation and that there is an increase in glucose uptake in response to insulin when expression of BVR is "knocked down" by small interfering RNA suggest a potential role for BVR in the insulin signaling pathway. PMID:15870194

  15. Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.

    PubMed

    Yuan, Dongjuan; Lan, Dongming; Xin, Ruipu; Yang, Bo; Wang, Yonghua

    2014-01-01

    Mono- and di-acylglycerol lipase has been applied to industrial usage in oil modification for its special substrate selectivity. Until now, the reported mono- and di-acylglycerol lipases from microorganism are limited, and there is no report on the mono- and di-acylglycerol lipase from bacteria. A predicted lipase (named MAJ1) from marine Janibacter sp. strain HTCC2649 was purified and biochemical characterized. MAJ1 was clustered in the family I.7 of esterase/lipase. The optimum activity of the purified MAJ1 occurred at pH 7.0 and 30 °C. The enzyme retained 50% of the optimum activity at 5 °C, indicating that MAJ1 is a cold-active lipase. The enzyme activity was stable in the presence of various metal ions, and inhibited in EDTA. MAJ1 was resistant to detergents. MAJ1 preferentially hydrolyzed mono- and di-acylglycerols, but did not show activity to triacylglycerols of camellia oil substrates. Further, MAJ1 is low homologous to that of the reported fungal diacylglycerol lipases, including Malassezia globosa lipase 1 (SMG1), Penicillium camembertii lipase U-150 (PCL), and Aspergillus oryzae lipase (AOL). Thus, we identified a novel cold-active bacterial lipase with a sn-1/3 preference towards mono- and di-acylglycerides for the first time. Moreover, it has the potential, in oil modification, for special substrate selectivity. PMID:24927145

  16. Structures and Activities of Archaeal Members of the LigD 3-Phosphoesterase DNA Repair Enzyme Superfamily

    SciTech Connect

    P Smith; P Nair; U Das; H Zhu; S Shuman

    2011-12-31

    LigD 3'-phosphoesterase (PE) is a component of the bacterial NHEJ apparatus that performs 3'-end-healing reactions at DNA breaks. The tertiary structure, active site and substrate specificity of bacterial PE are unique vis-a-vis other end-healing enzymes. PE homologs are present in archaea, but their properties are uncharted. Here, we demonstrate the end-healing activities of two archaeal PEs - Candidatus Korarchaeum cryptofilum PE (CkoPE; 117 amino acids) and Methanosarcina barkeri PE (MbaPE; 151 amino acids) - and we report their atomic structures at 1.1 and 2.1 {angstrom}, respectively. Archaeal PEs are minimized versions of bacterial PE, consisting of an eight-stranded {beta} barrel and a 3{sub 10} helix. Their active sites are located in a crescent-shaped groove on the barrel's outer surface, wherein two histidines and an aspartate coordinate manganese in an octahedral complex that includes two waters and a phosphate anion. The phosphate is in turn coordinated by arginine and histidine side chains. The conservation of active site architecture in bacterial and archaeal PEs, and the concordant effects of active site mutations, underscore a common catalytic mechanism, entailing transition state stabilization by manganese and the phosphate-binding arginine and histidine. Our results fortify the proposal that PEs comprise a DNA repair superfamily distributed widely among taxa.

  17. A New Member of the TBC1D15 Family from Chiloscyllium plagiosum: Rab GTPase-Activating Protein Based on Rab7 as a Substrate

    PubMed Central

    Li, Yuanyuan; Wang, Weidong; Cheng, Dandan; Wang, Tao; Lu, Conger; Chen, Jian; Nie, Zuoming; Zhang, Wenping; Lv, Zhengbing; Wu, Wutong; Shu, Jianhong

    2015-01-01

    APSL (active peptide from shark liver) is a hepatic stimulator cytokine from the liver of Chiloscyllium. It can effectively protect islet cells and improve complications in mice with alloxan-induced diabetes. Here, we demonstrate that the APSL sequence is present in the N-terminus of novel TBC (Tre-2, Bub2 and Cdc16) domain family, member 15 (TBC1D15) from Chiloscyllium plagiosum. This shark TBC1D15 gene, which contains an ORF of 2088 bp, was identified from a cDNA library of regenerating shark liver. Bioinformatic analysis showed that the gene is highly homologous to TBC1D15 genes from other species. Moreover, the N-terminus of shark TBC1D15 contains a motif of unknown function (DUF3548), which encompasses the APSL fragment. Rab-GAP activity analysis showed that shark TBC1D15 is a new member of the TBC1D15 family. These results demonstrated that shark TBC1D15 possesses Rab-GAP activity using Rab7 as a substrate, which is a common property of the TBC1D15 family. The involvement of APSL at the N-terminus of TBC1D15 also demonstrates that this protein might be involved in insulin signaling and may be associated with the development of type 2 diabetes. The current findings pave the way for further functional and clinical studies of these proteins from marine sources. PMID:25984991

  18. Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.

    PubMed Central

    Nunn, M F; Marsh, J W

    1996-01-01

    Although human immunodeficiency virus (HIV) Nef is essential for the induction of AIDS, its biochemical function has remained an enigma. In this study, HIV Nef protein is shown to associate with a serine-threonine kinase that recognizes histone H4 as a substrate, is serologically related to rat p21-activated kinase (PAK), and is specifically activated by Rac and Cdc42. These characteristics define the Nef-associated kinase as belonging to the PAK family. PAKs initiate kinase cascades in response to environmental stimuli, and their identification as a target of Nef implicates these signaling molecules in HIV pathogenesis and provides a novel target for clinical intervention. PMID:8709241

  19. Union Density and Hospital Outcomes.

    PubMed

    Koys, Daniel J; Martin, Wm Marty; LaVan, Helen; Katz, Marsha

    2015-01-01

    The authors address the hospital outcomes of patient satisfaction, healthcare quality, and net income per bed. They define union density as the percentage of a hospital's employees who are in unions, healthcare quality as its 30-day acute myocardial infraction (AMI; heart attack) mortality rate, and patient satisfaction as its overall Hospital Consumer Assessment of Healthcare Providers and Systems score. Using a random sample of 84 union and 84 nonunion hospitals from across the United States, multiple regression analyses show that union density is negatively related to patient satisfaction. Union density is not related to healthcare quality as measured by the AMI mortality rate or to net income per bed. This implies that unions per se are not good or bad for hospitals. The authors suggest that it is better for hospital administrators to take a Balanced Scorecard approach and be concerned about employee satisfaction, patient satisfaction, healthcare quality, and net income. PMID:26652043

  20. Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways.

    PubMed

    Guan, Hongtao; Shuaib, Aban; Leon, David Davila De; Angyal, Adrienn; Salazar, Maria; Velasco, Guillermo; Holcombe, Mike; Dower, Steven K; Kiss-Toth, Endre

    2016-01-01

    Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for the various binding partners may influence signalling control is currently unclear. We report that tribbles proteins can bind to an overlapping set of MAPK-kinases (MAPKK) in live cells and dictate the localisation of the complexes. Binding studies in transfected cells reveal common regulatory mechanisms and suggest that tribbles and MAPKs may interact with MAPKKs in a competitive manner. Computational modelling of the impact of tribbles on MAPK activation suggests a high sensitivity of this system to changes in tribbles levels, highlighting that these proteins are ideally placed to control the dynamics and balance of activation of concurrent signalling pathways. PMID:27600771

  1. Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways

    PubMed Central

    Guan, Hongtao; Shuaib, Aban; Leon, David Davila De; Angyal, Adrienn; Salazar, Maria; Velasco, Guillermo; Holcombe, Mike; Dower, Steven K.; Kiss-Toth, Endre

    2016-01-01

    Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for the various binding partners may influence signalling control is currently unclear. We report that tribbles proteins can bind to an overlapping set of MAPK-kinases (MAPKK) in live cells and dictate the localisation of the complexes. Binding studies in transfected cells reveal common regulatory mechanisms and suggest that tribbles and MAPKs may interact with MAPKKs in a competitive manner. Computational modelling of the impact of tribbles on MAPK activation suggests a high sensitivity of this system to changes in tribbles levels, highlighting that these proteins are ideally placed to control the dynamics and balance of activation of concurrent signalling pathways. PMID:27600771

  2. Federal Judge Rules against Faculty Union on Refunds of Nonmembers' Dues

    ERIC Educational Resources Information Center

    Glenn, David

    2008-01-01

    The faculty union at the City University of New York must make it easier for nonmembers to receive refunds of union dues spent on activities other than collective bargaining, a federal judge ruled this month. Magistrate Judge Lois Bloom, of the U.S. District Court in Brooklyn, found that the union, the Professional Staff Congress (or PSC),…

  3. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.

    PubMed

    Peeters, Miriam C; Mos, Iris; Lenselink, Eelke B; Lucchesi, Martina; IJzerman, Adriaan P; Schwartz, Thue W

    2016-05-01

    The adhesion G protein-coupled receptors [ADGRs/class B2 G protein-coupled receptors (GPCRs)] constitute an ancient family of GPCRs that have recently been demonstrated to play important roles in cellular and developmental processes. Here, we describe a first insight into the structure-function relationship of ADGRs using the family member ADGR subfamily G member 4 (ADGRG4)/GPR112 as a model receptor. In a bioinformatics approach, we compared conserved, functional elements of the well-characterized class A and class B1 secretin-like GPCRs with the ADGRs. We identified several potential equivalent motifs and subjected those to mutational analysis. The importance of the mutated residues was evaluated by examining their effect on the high constitutive activity of the N-terminally truncated ADGRG4/GPR112 in a 1-receptor-1-G protein Saccharomyces cerevisiae screening system and was further confirmed in a transfected mammalian human embryonic kidney 293 cell line. We evaluated the results in light of the crystal structures of the class A adenosine A2A receptor and the class B1 corticotropin-releasing factor receptor 1. ADGRG4 proved to have functionally important motifs resembling class A, class B, and combined elements, but also a unique highly conserved ADGR motif (H3.33). Given the high conservation of these motifs and residues across the adhesion GPCR family, it can be assumed that these are general elements of ADGR function.-Peeters, M. C., Mos, I., Lenselink, E. B., Lucchesi, M., IJzerman, A. P., Schwartz, T. W. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. PMID:26823453

  4. Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents.

    PubMed

    Vergelli, Claudia; Ciciani, Giovanna; Cilibrizzi, Agostino; Crocetti, Letizia; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Guerrini, Gabriella; Iacovone, Antonella; Giovannoni, Maria Paola

    2015-10-01

    A number of heterocycles bearing an arylpiperazinylalkyl side chain and structurally related to the previously described lead ET1 (4-amino-6-methyl-2-[3-(4-p-tolylpiperazin-1-yl)propyl]-5-vinylpyridazin-3(2H)-one) was synthesized and tested for their antinociceptive activity in Writhing Test. Many compounds, tested at doses of 20-40 mg/kg po were able to reduce the number of abdominal constrictions by more than 47% and, in same cases, the potency is comparable to lead ET1 as for 5e, 24a, 27b and 27c. The analgesia induced by the active compounds was completely prevented by pretreatment with α2-antagonist yohimbine, confirming the involvement of the adrenergic system in the mechanism of action for these new compounds. PMID:26361735

  5. The ETS family member ERM contains an alpha-helical acidic activation domain that contacts TAFII60.

    PubMed Central

    Defossez, P A; Baert, J L; Monnot, M; de Launoit, Y

    1997-01-01

    Transcription factors are modular entities built up of discrete domains, some devoted to DNA binding and others permitting transcriptional modulation. The structure of DNA binding domains has been thoroughly investigated and structural classes clearly defined. In sharp contrast, the structural constraints put on transactivating regions, if any, are mostly unknown. Our investigations focus on ERM, a eukaryotic transcription factor of the ETS family. We have previously shown that ERM harbours two transactivating domains (TADs) with distinct functional features: AD1 lies in the first 72 amino acids of ERM, while AD2 sits in the last 62. Here we show that AD1 is a bona fide acidic TAD, for it activated transcription in yeast cells, while AD2 did not. AD1 contains a 20 amino acid stretch predicted to form an alpha-helix that is found unchanged in the related PEA3 and ER81 transcription factors. Circular dichroism analysis revealed that a 32 amino acid peptide encompassing this region is unstructured in water but folds into a helix when the hydrophobic solvent trifluoroethanol is added. The isolated helix was sufficient to activate transcription and mutations predicted to disrupt it dramatically affected AD1-driven transactivation, whereas mutations decreasing its acidity had more gentle effects. A phenylalanine residue within the helix was particularly sensitive to mutations. Finally, we observed that ERM bound TAFII60 via AD1 and bound TBP and TAFII40, presumably via other activation domains. PMID:9358152

  6. The Vocational Training Policy of the European Union.

    ERIC Educational Resources Information Center

    Ruberti, Antonio

    1994-01-01

    LEONARDO, the European Union's new vocational training action program, provides a political and operational tool to address the following: improving quality and innovation capacity, encouraging partnerships, and reinforcing activities through monitoring and evaluation. (JOW)

  7. Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems: VapBC-5 from Mycobacterium tuberculosis

    SciTech Connect

    Miallau, L.; Faller, M.; Chiang, J.; Arbing, M.; Guo, F.; Cascio, D.; Eisenberg, D.

    2009-03-02

    In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapBC family of complexes from M. tuberculosis. The toxin VapC-5 is a compact, 150 residues, two domain {alpha}/{beta} protein. Bent around the toxin is the VapB-5 antitoxin, a 33-residue {alpha}-helix. Assays suggest that the toxin is an Mg-enabled endoribonuclease, inhibited by the antitoxin. The lack of DNase activity is consistent with earlier suggestions that the complex represses its own operon. Furthermore, analysis of the interactions in the binding of the antitoxin to the toxin suggest that exquisite control is required to protect the bacteria cell from toxic VapC-5.

  8. V-band Photometry Of By Draconis-type Variables; Probing Long-term Activity Cycles In Three Pleiades Members

    NASA Astrophysics Data System (ADS)

    Milingo, Jackie; Thomson, A. D.; Truong, P. N.; Marschall, L. A.; Backman, D. E.

    2007-05-01

    Through the collaborative efforts of undergraduates and faculty at Gettysburg and Franklin & Marshall Colleges, we present the compilation of 10 years of differential photometry for three K-type stars in the Pleiades. These young stars have rotational light curves with V-band amplitudes of a few percent (10% in the most active) due to BY Draconis-type behavior (modulation due to rotation of a star with non-uniform surface brightness). With 10 years of photometry reduced, measured, and compiled we are now in a position to probe the V-band variations in these stars for indications of the extent of brightness asymmetry in the photosphere, and characteristics of the long-term activity of these stars. These observations were acquired at the National Undergraduate Research Observatory, operated by Lowell Observatory and Northern Arizona University. This work is supported by Gettysburg College, the Pennsylvania Space Grant Consortium, Arizona Space Grant, NSF grant AST-0354056, and by the Nantucket Maria Mitchell Association.

  9. International Scientific Unions and Global Research

    NASA Astrophysics Data System (ADS)

    Beer, T.

    2013-05-01

    This presentation will deal with the role that international scientific unions play in coordinating international research efforts. Rather than give a general, theoretical, talk on the role that ICSU - the International Council of Science - plays in International Science, I will briefly outline their role and then focus on a case study relevant to the International Union of Geodesy and Geophysics (IUGG). I will compare the scientific activities, and the outreach and education activities, of two major international research programs - the International Year of Planet Earth and the International Polar Year. These were two of the IGY+50 activities. Past informal polls of conference attendees to determine how many had heard of each IGY+50 event result in. eGY (electronic Geophysical Year) 1% IHY (International Heliophysical Year) 4% IYPE (International Year of Planet Earth) 31% IPY (International Polar Year) 64% Why is IPY the one of which most scientists are aware?

  10. Reactions of community members regarding community health workers’ activities as a measure of the impact of a training program in Amazonas, Brazil

    PubMed Central

    Kawasaki, Ryoko; Sadamori, Toru; Ferreira de Almeida, Terezinha; Akiyoshi, Megumi; Nishihara, Mika; Yoshimura, Toshiro; Ohnishi, Mayumi

    2014-01-01

    Objectives: The aim of this study was to evaluate the impact of community health worker (CHW) training on recognition and satisfaction regarding the performance of CHWs among members of the community in Amazonas, Brazil, which is a resource-poor area underserved with regard to medical health-care accessibility. Methods: Baseline and endline surveys concerning recognition and satisfaction with respect to CHW performance among members of the community were conducted by interview using a questionnaire before and after implementation of a program to strengthen community health projects in Manicoré, Amazonas, Brazil. One of the components of the project was CHW refresher training, which focused on facilitating adequate use of health-care services and providing primary health care, including health guidance. The baseline survey was performed in February 2004 at the beginning of the project, and the endline survey was performed in February 2006 at the end of the project. There were 82 and 120 CHWs working in Manicoré at the times of the baseline and endline surveys, respectively. Statistical analysis was performed to determine the significance of changes in experience with CHW activities, expected functions of CHWs, and satisfaction regarding the performance of CHWs between the baseline and endline surveys. In addition, qualitative analysis was conducted to evaluate the acceptability, feasibility, and sustainability of CHW refresher training. Results: Overall recognition and level of satisfaction regarding CHW performance among members of the community were improved from the baseline to the endline survey, regardless of type of residential area, such as town and/or remote area. Members of the community came to not expect CHWs to “provide strong medicine” (P < 0.001) and “provide injections” (P < 0.001), and came to appreciate “go to hospital with a sick person” (P = 0.031) as a function and role of CHWs. Conclusions: The results of the present study

  11. Episodic ataxia type 2 manifests as epileptiform electroencephalographic activity with no epileptic attacks in two family members.

    PubMed

    Kaido, Misako; Furuta, Mitsuru; Nakamori, Masayuki; Yuasa, Yoshihito; Takahashi, Masanori P

    2016-04-28

    Here, we report two cases of episodic ataxia type 2 (EA2) in a 63-year-old woman and her 36-year-old daughter. The mother experienced recurrent attacks of cerebellar dysfunction lasting 4 to 5 hours since the age of 41 years. On several occasions, she was admitted to the emergency room, where she was diagnosed with epilepsy or stroke. Based on these diagnoses, she was treated with antiepileptic or anticoagulant drugs, but both treatments were eventually discontinued. The frequency of the attacks increased after the patient reached the age of 62. Interictal neurological examination demonstrated signs of slight cerebellar ataxia, i.e. saccadic eye movements, gaze-directed nystagmus, and mild truncal ataxia. Brain magnetic resonance imaging (MRI) showed cerebellar vermis atrophy. Electroencephalography (EEG) revealed various spike and wave patterns: solitary spikes, spike-and-slow wave complexes, and slow wave bursts. Photoparoxysmal response (PPR) type 3 was also observed. Treatment with acetazolamide abolished the patient's attacks almost completely. The daughter started experiencing 5- to 10-minute ataxic episodes at the age of 16 years. Based on her epileptiform EEG activities with PPR (type 2), antiepileptic drugs (valproate and zonisamide) were prescribed. Despite pharmacological treatment, the attacks recurred; however, their frequency gradually decreased with time, until they almost entirely disappeared when the patient was 33. Unfortunately, migraine-like headaches arose instead. Subtle truncal ataxia was observed during interictal periods. Sanger sequencing of the exons of the CACNA1A gene revealed a novel single base deletion (c.3575delA) in both patients. Despite the difference in age of onset and clinical course, both patients showed clearly epileptiform EEG activities without experiencing the concurrent epileptic episodes. Thus, EA2 is a disease that may be misdiagnosed as epilepsy or stroke in the field of emergency medicine. PMID:27025991

  12. Breast cancer in European Union: an update of screening programmes as of March 2014 (review).

    PubMed

    Altobelli, E; Lattanzi, A

    2014-11-01

    Breast cancer, a major cause of female morbidity and mortality, is a global health problem; 2008 data show an incidence of ~450,000 new cases and 140,000 deaths (mean incidence rate 70.7 and mortality rate 16.7, world age-standardized rate per 100,000 women) in European Union Member States. Incidence rates in Western Europe are among the highest in the world. We review the situation of BC screening programmes in European Union. Up to date information on active BC screening programmes was obtained by reviewing the literature and searching national health ministries and cancer service websites. Although BC screening programmes are in place in nearly all European Union countries there are still considerable differences in target population coverage and age and in the techniques deployed. Screening is a mainstay of early BC detection whose main weakness is the rate of participation of the target population. National policies and healthcare planning should aim at maximizing participation in controlled organized screening programmes by identifying and lowering any barriers to adhesion, also with a view to reducing healthcare costs. PMID:25174328

  13. 22 CFR 124.16 - Special retransfer authorizations for unclassified technical data and defense services to member...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... unclassified technical data and defense services to member states of NATO and the European Union, Australia... NATO and the European Union, Australia, Japan, New Zealand, and Switzerland. The provisions of § 124.8...-licensees, provided they are nationals exclusively of countries that are members of NATO the European...

  14. 22 CFR 124.16 - Special retransfer authorizations for unclassified technical data and defense services to member...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... unclassified technical data and defense services to member states of NATO and the European Union, Australia... NATO and the European Union, Australia, Japan, New Zealand, and Switzerland. The provisions of § 124.8...-licensees, provided they are nationals exclusively of countries that are members of NATO the European...

  15. 22 CFR 124.16 - Special retransfer authorizations for unclassified technical data and defense services to member...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... unclassified technical data and defense services to member states of NATO and the European Union, Australia... NATO and the European Union, Australia, Japan, New Zealand, and Switzerland. The provisions of § 124.8...-licensees, provided they are nationals exclusively of countries that are members of NATO the European...

  16. A Credit-Union Project.

    ERIC Educational Resources Information Center

    Schmidt, Mary Ellen

    1997-01-01

    Describes establishing and running a credit union in a sixth-grade classroom. By establishing a classroom credit union, students can develop independence in solving real problems and model situations that occur in the real world to solve similar problems. (ASK)

  17. A Trade Union Sponsored Scheme

    ERIC Educational Resources Information Center

    Eddy, Max; Corcoran, J. P.

    1969-01-01

    Professor Max Eddy, Head of Purdue University's Department of Industrial Education, with the assistance of J.P. Corcoran, Director of a trade union training department, describe the development of a programme of training for apprentice instructors run jointly by the union and the university. (Editor)

  18. Teaching Reform and Union Reform.

    ERIC Educational Resources Information Center

    Kerchner, Charles T.; Mitchell, Douglas E.

    1986-01-01

    Reviews present labor statutes and examines three alternatives to current practices; proposes that teaching, by its nature, is not well administered by industrial standards or well adjudicated through industrial unionism. Suggests "professional unionism" as a means of effecting educational reform. (DR)

  19. Recent Developments in Compulsory Unionism.

    ERIC Educational Resources Information Center

    Mitchnick, Morton G.

    1993-01-01

    Looks at legal cases concerning the uses to which mandatory union dues are put. Considers the variety of approaches adopted in Switzerland, Spain, Belgium, and Germany and reviews how compulsory unionism has been treated in the courts in the United Kingdom, Denmark, the United States, and Canada. (JOW)

  20. Union Roles in Workplace Literacy.

    ERIC Educational Resources Information Center

    Hensley, Stephen Michael

    1993-01-01

    Discusses roles for labor unions in resolving workforce deficiencies, suggesting that labor, management, and government must work together to develop cooperative training initiatives. Describes labor's historic role in basic and workplace literacy training, lists skills workers need in the "new" workplace, describes exemplary union-management…

  1. Toward a More Perfect Union

    ERIC Educational Resources Information Center

    Schachter, Ron

    2010-01-01

    This article explores school districts such as New Haven (Connecticut) Public Schools, whose local union is an American Federation of Teachers (AFT) affiliate and where a shared concern for students has trumped the often adversarial union-management relationship. The author discusses what makes the successful contract negotiations headed by David…

  2. Thinking about the Soviet Union.

    ERIC Educational Resources Information Center

    Perkovich, George

    In the United States, educators have had difficulty teaching about the Soviet Union. Students are often ignorant of the historical circumstances that have affected the U.S./Soviet relationship, and they are often miseducated by stereotypes they encounter in popular culture. This curriculum explores the government and economy of the Soviet Union,…

  3. Professional Employees Turn to Unions

    ERIC Educational Resources Information Center

    Chamot, Dennis

    1976-01-01

    White-collar and professional employees are increasingly turning to unions to combat their loss of independence as employees of large organizations. Managers should realize that they and professional employees have different viewpoints about job situations and that the current trend toward white-collar unionism is apt to continue. (JG)

  4. College/Labor Union Cooperation

    ERIC Educational Resources Information Center

    Abbott, William

    1977-01-01

    A survey of 1,054 institutions by the AACJC Service Center for Community College-Labor Union Cooperation concluded that while substantial joint undertakings exist between unions and community colleges, in many cases labor and community colleges are waiting for the other party to make the first move. (JG)

  5. Teacher Unionization in School Governance

    ERIC Educational Resources Information Center

    Jacoby, Dan

    2011-01-01

    The role of unions in school governance is reviewed to note that labor operates in a larger context of principal-agent relationships. As agents for teachers, unions articulate the concerns that must be addressed if teachers are to be successfully enlisted in the struggle to reduce achievement gaps among at-risk students. Transcending industrial…

  6. Synthesis of seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one and their HIV-RT inhibitory activity.

    PubMed

    Hou, Yuheng; Xing, Shunkai; Shao, Jie; Yin, Zhuqing; Hao, Le; Yang, Tianyu; Zhang, Hongzhi; Zhu, Mo; Chen, Hua; Li, Xiaoliu

    2016-06-24

    Novel seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one were conveniently synthesized by the tandem Staudinger/aza-Wittig/cyclization reaction under microwave radiation. Benzoyl group (Bz) migrations were found in the synthesis of 8c and 9b using D-galactoside or D-mannoside as starting materials, respectively, which was suggested by HMBC and X-ray. The new bi/tricyclic iminosugars 3~4(a-d) and 5(b-d) were examined for their HIV reverse transcriptase (RT) inhibitory activities. The result showed that all compounds except 5b could effectively inhibit RT activity. Among them, compounds 3c and 4c were the best ones with the IC50 values of RT inhibitory activities of 2.11 µM and 2.73 µM, respectively. Structure-activity relationship analysis suggested that the phenyl group in the tricyclic azasugars was beneficial for their anti-HIV RT activity. PMID:27017974

  7. The Role of Labor Unions in Creating Working Conditions That Promote Public Health.

    PubMed

    Hagedorn, Jenn; Paras, Claudia Alexandra; Greenwich, Howard; Hagopian, Amy

    2016-06-01

    We sought to portray how collective bargaining contracts promote public health, beyond their known effect on individual, family, and community well-being. In November 2014, we created an abstraction tool to identify health-related elements in 16 union contracts from industries in the Pacific Northwest. After enumerating the contract-protected benefits and working conditions, we interviewed union organizers and members to learn how these promoted health. Labor union contracts create higher wage and benefit standards, working hours limits, workplace hazards protections, and other factors. Unions also promote well-being by encouraging democratic participation and a sense of community among workers. Labor union contracts are largely underutilized, but a potentially fertile ground for public health innovation. Public health practitioners and labor unions would benefit by partnering to create sophisticated contracts to address social determinants of health. PMID:27077343

  8. Union-Active School Librarians and School Library Advocacy: A Modified Case Study of the British Columbia Teacher-Librarians' Association and the British Columbia Teachers' Federation

    ERIC Educational Resources Information Center

    Ewbank, Ann Dutton

    2015-01-01

    This modified case study examines how the members of the British Columbia Teacher-Librarians' Association (BCTLA), a Provincial Specialist Association (PSA) of the British Columbia Teachers' Federation (BCTF), work together to advocate for strong school library programs headed by a credentialed school librarian. Since 2002, despite nullification…

  9. ARRY-334543 reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2

    PubMed Central

    Wang, De-Shen; Patel, Atish; Sim, Hong-May; Zhang, Yun-Kai; Wang, Yi-Jun; Kathawala, Rishil J.; Zhang, Hui; Talele, Tanaji T.; Ambudkar, Suresh V.; Xu, Rui-Hua; Chen, Zhe-Sheng

    2014-01-01

    Background ARRY-334543 is a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases. We conducted this study to determine whether ARRY-334543 can enhance the efficacy of conventional anticancer drugs through interaction with ABC transporters. Methods Lung cancer cell line NCI-H460 and its ABCG2-overexpressing NCI-H460/MX20, as well as the ABCG2-, ABCB1-, and ABCC10-overexpressing transfected cell lines were used for the reversal study. Results Our results demonstrate that ARRY-334543 (1.0 μM) significantly reversed ABCG2-mediated multidrug resistance (MDR) by directly inhibiting the drug efflux function of ABCG2, resulting in the elevated intracellular accumulation of chemotherapeutic drugs in the ABCG2-overexpressing cell lines. In addition, in isolated membranes, ARRY-334543 stimulated ATPase activity and inhibited photolabeling of ABCG2 with [125I]-iodoarylazidoprazosin in a concentration-dependent manner indicating that this drug directly interacts at the drug-binding pocket of this transporter. ARRY-334543 (1.0 μM) only slightly reversed ABCB1- and partially reversed ABCC10-mediated MDR suggesting that it exhibits high affinity towards ABCG2. Moreover, homology modeling predicted the binding conformation of ARRY-334543 at Arg482 centroid-based grid of ABCG2. However, ARRY-334543 at reversal concentration did not affect the expression level of ABCG2, AKT and ERK1/2 and regulate the re-localization of ABCG2. Conclusion We conclude that ARRY-334543 significantly reverses drug resistance mediated by ABCG2. PMID:24939447

  10. Development and testing of virtual reality exposure therapy for post-traumatic stress disorder in active duty service members who served in Iraq and Afghanistan.

    PubMed

    McLay, Robert N; Graap, Kenneth; Spira, James; Perlman, Karen; Johnston, Scott; Rothbaum, Barbara O; Difede, JoAnn; Deal, William; Oliver, David; Baird, Alicia; Bordnick, Patrick S; Spitalnick, Josh; Pyne, Jeffrey M; Rizzo, Albert

    2012-06-01

    This study was an open-label, single-group, treatment-development project aimed at developing and testing a method for applying virtual reality exposure therapy (VRET) to active duty service members diagnosed with combat post-traumatic stress disorder (PTSD). Forty-two service members with PTSD were enrolled, and 20 participants completed treatment. The PTSD Checklist-Military version, Patient Health Questionnaire-9 for depression, and the Beck Anxiety Inventory were used as outcome measures. Of those who completed post-treatment assessment, 75% had experienced at least a 50% reduction in PTSD symptoms and no longer met DSM-IV criteria for PTSD at post treatment. Average PSTD scores decreased by 50.4%, depression scores by 46.6%, and anxiety scores by 36%. Intention-to-treat analyses showed that statistically significant improvements in PTSD, depression, and anxiety occurred over the course of treatment and were maintained at follow up. There were no adverse events associated with VRET treatment. This study provides preliminary support for the use of VRET in combat-related PTSD. Further study will be needed to determine the wider utility of the method and to determine if it offers advantages over other established PTSD treatment modalities. PMID:22730837

  11. Union Presence, Class, and Individual Earnings Inequality.

    ERIC Educational Resources Information Center

    Leicht, Kevin T.; And Others

    1993-01-01

    Data from the Survey of Class Structure and Class Consciousness showed that union membership positively affects earnings of all workers, but union density affects only the working class. Interindustry union threats affect the wages of only nonunionized workers. (SK)

  12. Trade Unions and the Economics Curriculum.

    ERIC Educational Resources Information Center

    Veale, Sarah

    1987-01-01

    Contends that a realistic approach to teaching economics requires learning about trade unions. Presents a role play of a trade union meeting that helps students think about how trade unions tackle problems. (BSR)

  13. Durations of service until first and recurrent episodes of clinically significant back pain, active component military members: changes among new accessions to service since calendar year 2000.

    PubMed

    Brundage, John F; Hu, Zheng; Clark, Leslie L

    2016-01-01

    This report summarizes frequencies and timing of first and recurrent episodes of back pain treated in the U.S. Military Health System among more than 2 million military members who began active service between July 2000 and June 2012. In the population overall, at least 5% were affected by clinically significant back pain within 6 months and 10% within 13 months of beginning active service; and 34% had at least one episode of back pain while in active service during the surveillance period. After initial episodes of back pain, more than half (54%) of those affected had at least one recurrent episode; and after first recurrences, 65% had second recurrences while still in active service. In general, back pain episode-free periods preceding initial and between successive episodes markedly decreased during the period. Frequencies and timing of back pain episodes varied in relation to service branch, gender, and occupation. Acute back pain is a common disorder that is unpredictable in onset and often debilitating. Its prevention should be a military medical research objective of high priority. PMID:26836203

  14. Tfs1p, a Member of the PEBP Family, Inhibits the Ira2p but Not the Ira1p Ras GTPase-Activating Protein in Saccharomyces cerevisiae

    PubMed Central

    Chautard, Hélène; Jacquet, Michel; Schoentgen, Françoise; Bureaud, Nicole; Bénédetti, Hélène

    2004-01-01

    Ras proteins are guanine nucleotide-binding proteins that are highly conserved among eukaryotes. They are involved in signal transduction pathways and are tightly regulated by two sets of antagonistic proteins: GTPase-activating proteins (GAPs) inhibit Ras proteins, whereas guanine exchange factors activate them. In this work, we describe Tfs1p, the first physiological inhibitor of a Ras GAP, Ira2p, in Saccharomyces cerevisiae. TFS1 is a multicopy suppressor of the cdc25-1 mutation in yeast and corresponds to the so-called Ic CPY cytoplasmic inhibitor. Moreover, Tfs1p belongs to the phosphatidylethanolamine-binding protein (PEBP) family, one member of which is RKIP, a kinase and serine protease inhibitor and a metastasis inhibitor in prostate cancer. In this work, the results of (i) a two-hybrid screen of a yeast genomic library, (ii) glutathione S-transferase pulldown experiments, (iii) multicopy suppressor tests of cdc25-1 mutants, and (iv) stress resistance tests to evaluate the activation level of Ras demonstrate that Tfs1p interacts with and inhibits Ira2p. We further show that the conserved ligand-binding pocket of Tfs1—the hallmark of the PEBP family—is important for its inhibitory activity. PMID:15075275

  15. Differences in Muscle and Adipose Tissue Gene Expression and Cardio-Metabolic Risk Factors in the Members of Physical Activity Discordant Twin Pairs

    PubMed Central

    Leskinen, Tuija; Rinnankoski-Tuikka, Rita; Rintala, Mirva; Seppänen-Laakso, Tuulikki; Pöllänen, Eija; Alen, Markku; Sipilä, Sarianna; Kaprio, Jaakko; Kovanen, Vuokko; Rahkila, Paavo; Orešič, Matej; Kainulainen, Heikki; Kujala, Urho M.

    2010-01-01

    High physical activity/aerobic fitness predicts low morbidity and mortality. Our aim was to identify the most up-regulated gene sets related to long-term physical activity vs. inactivity in skeletal muscle and adipose tissues and to obtain further information about their link with cardio-metabolic risk factors. We studied ten same-sex twin pairs (age range 50–74 years) who had been discordant for leisure-time physical activity for 30 years. The examinations included biopsies from m. vastus lateralis and abdominal subcutaneous adipose tissue. RNA was analyzed with the genome-wide Illumina Human WG-6 v3.0 Expression BeadChip. For pathway analysis we used Gene Set Enrichment Analysis utilizing active vs. inactive co-twin gene expression ratios. Our findings showed that among the physically active members of twin pairs, as compared to their inactive co-twins, gene expression in the muscle tissue samples was chronically up-regulated for the central pathways related to energy metabolism, including oxidative phosphorylation, lipid metabolism and supportive metabolic pathways. Up-regulation of these pathways was associated in particular with aerobic fitness and high HDL cholesterol levels. In fat tissue we found physical activity-associated increases in the expression of polyunsaturated fatty acid metabolism and branched-chain amino acid degradation gene sets both of which associated with decreased ‘high-risk’ ectopic body fat and plasma glucose levels. Consistent with other findings, plasma lipidomics analysis showed up-regulation of the triacylglycerols containing the polyunsaturated fatty acids. Our findings identified skeletal muscle and fat tissue pathways which are associated with the long-term physical activity and reduced cardio-metabolic disease risk, including increased aerobic fitness. In particular, improved skeletal muscle oxidative energy and lipid metabolism as well as changes in adipocyte function and redistribution of body fat are associated with

  16. Personality characteristics of Wikipedia members.

    PubMed

    Amichai-Hamburger, Yair; Lamdan, Naama; Madiel, Rinat; Hayat, Tsahi

    2008-12-01

    Wikipedia is an online, free access, volunteer-contributed encyclopedia. This article focuses on the Wikipedians' (Wikipedia users) personality characteristics, studying Wikipedians' conceptions of Real-Me and BFI dimensions. To survey these aspects, we posted links to two online web questionnaires; one was targeted at Wikipedians and the second to non-Wikipedia users. One hundred and thirty-nine subjects participated in the study, of which 69 were active Wikipedia members. It was found that Wikipedia members locate their real me on the Internet more frequently as compared to non-Wikipedia members. Variance analysis revealed significant differences between Wikipedia members and non-Wikipedia members in agreeableness, openness, and conscientiousness, which were lower for the Wikipedia members. An interaction was found between Wikipedia membership and gender: introverted women were more likely to be Wikipedia members as compared with extroverted women. The results of this study are discussed with special emphasis on the understanding of the motivators of Wikipedia members. PMID:18954273

  17. 77 FR 23539 - WTO Dispute Settlement Proceeding Regarding European Communities and Certain Member States...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ... European Union (``EU'') member state governments of France, Germany, Spain, and the United Kingdom to... TRADE REPRESENTATIVE WTO Dispute Settlement Proceeding Regarding European Communities and Certain Member... dispute European Communities and Certain Member States--Measures Affecting Trade in Large Civil...

  18. 12 CFR 723.5 - How do you implement a member business loan program?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false How do you implement a member business loan... CREDIT UNIONS MEMBER BUSINESS LOANS § 723.5 How do you implement a member business loan program? (a) Generally. The board of directors must adopt specific business loan policies and review them at...

  19. 12 CFR Appendix A to Part 748 - Guidelines for Safeguarding Member Information

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... terms used in these Guidelines have the same meanings as set forth in 12 CFR part 716. 2. For purposes... lists, and tenant screening reports. c. Member means any member of the credit union as defined in 12 CFR... defined in 12 CFR 716.3(q), about a member, whether in paper, electronic, or other form, that...

  20. Top Ten Workplace Issues for Faculty Members and Higher Education Professionals

    ERIC Educational Resources Information Center

    Petry, Greta

    2011-01-01

    A faculty member may be surprised to hear that the AAUP-affiliated United University Professions--one of the largest academic unions in the nation, with more than 33,000 members across New York State--includes a growing number of academic professionals who are not faculty members. Professionals at a public college or university range from the…

  1. A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages

    PubMed Central

    Won, Kyung-Jong; Park, Sung-Won; Lee, Seunghoon; Kong, Il-Keun; Chae, Jung-Il; Kim, Bokyung; Lee, Eun-Jong

    2015-01-01

    The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages. PMID:26557807

  2. Uranium mine and mill tailings - Liabilities in the European Union

    SciTech Connect

    Hilden, Wolfgang; Murphy, Simon; Vrijen, Jan

    2007-07-01

    Available in abstract form only. Full text of publication follows: Uranium mining and milling has taken place on large scale in the Member States of the European Union (EU) for some 60 years. Although, compared to mining, milling activities are normally concentrated in fewer locations, this can still result in a relatively large number of disposal sites for the tailings, compared to other radioactive wastes. In addition these sites are also quite large, in terms of both volume and surface area. Coupled with the residual uranium in the tailings together with other radionuclides, heavy metals, chemicals etc this results in an environmental legacy continuing far into the future. Often during production no or little provision has been made for the closure, remediation and future supervision of such sites. In 1996 the European Commission funded an inventory of uranium mining and milling liabilities in nine Central and Eastern European Countries. Additionally, pilot projects were funded to carry out remediation activities at several sites. Almost ten years later the Commission has identified the need to address the situation of these large liabilities in all EU Member States and to assess the progress made in remediation of the sites, especially in view of the closure of almost all mining activities in Europe. The Commission study has identified the current tailings liabilities in Europe, their status, the future plans for these sites and the hazards that continue to be associated with them. It is clear that although considerable progress has been made in recent years, much work remains to be carried out in the areas of remediation, and ensuring the long-term safety of many of the identified objects. The paper presents the main findings of the study, as well as the challenges identified to ensure long-term safety of these wastes. (authors)

  3. Turbidity current activity along the flanks of a volcanic edifice: The Mafate volcaniclastic complex, La Réunion Island, Indian Ocean

    NASA Astrophysics Data System (ADS)

    Mazuel, Aude; Sisavath, Emmanuelle; Babonneau, Nathalie; Jorry, Stephan J.; Bachèlery, Patrick; Delacourt, Christophe

    2016-04-01

    Recent marine geophysical surveys reveal the existence of well-developed volcaniclastic deep-sea fans around La Réunion Island, Indian Ocean. The Mafate turbidite complex, located in the northwestern part of the island, is a large sedimentary system formed by two coalescent-like volcaniclastic deep-sea fans: the Mafate fan and the Saint-Denis fan. They are both connected to terrestrial rivers supplying sediment produced by erosion on the island, particularly during austral summer cyclonic floods. Through the integration of marine geophysical data (including bathymetry, backscatter multibeam sounder images, TOBI side-scan sonar images and seismic reflection profiles) and piston cores, a submarine morpho-sedimentary map of the surface architecture of the Mafate and Saint-Denis turbidite systems has been established. The systems are divided in three main domains: deep canyons in the proximal area, a channel network in the medial area, and distal depositional lobes on the abyssal sea floor. Two large sediment wave fields also formed as a result of the volcaniclastic turbidity currents. Three piston cores collected along the Mafate complex provide information on the sedimentary processes in this area over the last 25 ka. The record of turbidite events in these cores is interpreted in terms of volcanic and climatic changes that could have controlled the sediment transfer to the deep ocean.

  4. RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

    PubMed Central

    Ganju, Ramesh K.; Hatch, William C.; Avraham, Hava; Ona, Mel A.; Druker, Brian; Avraham, Shalom; Groopman, Jerome E.

    1997-01-01

    The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has previously been reported to participate in signal transduction in neuronal cells, megakaryocytes, and B lymphocytes. We have found that RAFTK is constitutively expressed in human T cells and is rapidly phosphorylated upon the activation of the T cell receptor (TCR). This activation also results in an increase in the autophosphorylation and kinase activity of RAFTK. After its stimulation, there was an increase in the association of the src cytoplasmic tyrosine kinase Fyn and the adapter protein Grb2. This association was mediated through the SH2 domains of Fyn and Grb2. RAFTK also co-immunoprecipitates with the SH2 domain of Lck and with the cytoskeletal protein paxillin through its COOH-terminal proline-rich domain. The tyrosine phosphorylation of RAFTK after T cell receptor-mediated stimulation was reduced by the pretreatment of cells with cytochalasin D, suggesting the role of the cytoskeleton in this process. These observations indicate that RAFTK participates in T cell receptor signaling and may act to link signals from the cell surface to the cytoskeleton and thereby affect the host immune response. PMID:9091579

  5. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could ...

  6. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evidence supports the theory that the bacterial communities colonizing E. purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be a...

  7. Schools for Democracy: Labor Union Participation and Latino Immigrant Parents' School-Based Civic Engagement

    ERIC Educational Resources Information Center

    Terriquez, Veronica

    2011-01-01

    Scholars have long argued that civic organizations play a vital role in developing members' civic capacity. Yet few empirical studies examine how and the extent to which civic skills transfer across distinct and separate civic contexts. Focusing on Latino immigrant members of a Los Angeles janitors' labor union, this article fills a void by…

  8. The applicability and availability of Former Soviet Union (FSU) space-related capabilities and facilities to energy-related space activities of Department of Energy, Department of Defense and National Aeronautics and Space Administration

    NASA Astrophysics Data System (ADS)

    Pellechi, M.

    1993-01-01

    A senior-level Department of Energy (DOE), Department of Defense (DoD), and National Aeronautics and Space Administration (NASA) team visited the former Soviet Union (FSU) from 16-28 Oct. 1992. The purpose of the visit was to investigate the applicability and availability of FSU space-related capabilities and facilities to the energy-related space activities of the three agencies. This included renewable energy, nuclear power and propulsion, radiation effects, remote sensing, optics, and lasers. The U.S. delegation was successful in identifying some capabilities that would be useful to the three organizations. Efforts to utilize some of the FSU capabilities viewed are being initiated. Concurrently, there will be a technical assessment performed on the information gained from this and other recent visits to the FSU relative to space research.

  9. Strained Si-O-Si bonds in amorphous SiO2 materials: A family member of active centers in radio, photo, and chemical responses

    NASA Astrophysics Data System (ADS)

    Awazu, Koichi; Kawazoe, Hiroshi

    2003-11-01

    Amorphous SiO2 (a-SiO2), such as bulk silica glasses and thin films has been one of the key materials in modern optoelectronic industries. These materials are currently used in communication technologies as optical fibers, thin films for electrical insulation in dynamic random access memories (DRAM), and optical lenses for excimer laser lithography, for example. The property essential for these applications is the wide band gap amounting to ˜9 eV. However, bulk silica glasses commercially available and silica thin films show photoresponses to subband gap lights in the vicinity of 5 eV and unexpected trapping of charges, and the behavior has a strong dependency on the preparation history. A number of studies were carried out to clarify the relationship between the properties and structural imperfections in the materials and the formation mechanisms of the defects. There are two categories of the imperfections: one is dopant- or impurity-related imperfections and the other is nonstoichiometry related defects. These defects constitute gap states in a-SiO2. The structural identification was usually performed by absorption and emission spectroscopy in the visible-ultraviolet (UV) region and electron spin resonance (ESR). The experimentally proposed models were compared with the predictions by theoretical calculations of energy levels. Recent development of the excimer laser lithography technique led us to recognize that a latent member, which has been unnoticed because of no response to the optical absorption or emission in the visible-UV range and ESR absorption, exists in the family of active centers in a-SiO2, that is a strained Si-O-Si bond originating from the planar three membered ring. In contrast, the puckered four membered ring is unstrained. Although it has been pointed out that there was a wide distribution in Si-O-Si bond angle from 90° to 180° by x-ray analysis or 29Si solid state nuclear magnetic resonance, the physical, and chemical responses of the Si

  10. Union Power for Teaching Assistants

    ERIC Educational Resources Information Center

    Mitzman, Barry

    1975-01-01

    The Teaching Assistants Association (TAA) is a labor union representing the graduate students who teach most of the University of Wisconsin and the University of Michigan freshman and sophomore courses. (Author/PG)

  11. Faculty Union Movement Gains Momentum

    ERIC Educational Resources Information Center

    Seltzer, Richard J.

    1975-01-01

    Describes the causes of the increase in faculty unionism over the past eight years and describes a report prepared for the Carnegie Commission and the Ford Foundation which analyzes this new campus development. (GS)

  12. Agreement between the Board of Trustees of Union County College and the Union County College Chapter of the American Association of University Professors, September 1, 1984-August 31, 1987.

    ERIC Educational Resources Information Center

    Union Coll., Cransford, NJ.

    The collective bargaining agreement between Union County College Board of Trustees and the Union County College Chapter (100 members) of the American Association of University Professors (AAUP) covering the period September 1, 1984-August 31, 1987 is presented. Items covered in the agreement include: definitions and AAUP recognition, chapter…

  13. Synthesis, characterization and in vitro anticancer activity of 18-membered octaazamacrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II)

    NASA Astrophysics Data System (ADS)

    Kareem, Abdul; Zafar, Hina; Sherwani, Asif; Mohammad, Owais; Khan, Tahir Ali

    2014-10-01

    An effective series of 18 membered octaazamacrocyclic complexes of the type [MLX2], where X = Cl or NO3 have been synthesized by template condensation reaction of oxalyl dihydrazide with dibenzoylmethane and metal salt in 2:2:1 molar ratio. The formation of macrocyclic framework, stereochemistry and their overall geometry have been characterized by various physico-chemical studies viz., elemental analysis, electron spray ionization-mass spectrometry (ESI-MS), I.R, UV-Vis, 1H NMR, 13C NMR spectroscopy, X-ray diffraction (XRD) and TGA/DTA studies. These studies suggest formation of octahedral macrocyclic complexes of Co(II), Ni(II), Cd(II) and Sn(II). The molar conductance values suggest nonelectrolytic nature for all the complexes. Thermogravimatric analysis shows that all the complexes are stable up to 600 °C. All these complexes have been tested against different human cancer cell lines i.e. human hepatocellular carcinoma (Hep3B), human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF7) and normal cells (PBMC). The newly synthesized 18-membered octaazamacrocyclic complexes during in vitro anticancer evaluation, displayed moderate to good cytotoxicity on liver (Hep3B), cervical (HeLa) and breast (MCF7) cancer cell lines, respectively. The most effective anticancer cadmium complex (C34H28N10CdO10) was found to be active with IC50 values, 2.44 ± 1.500, 3.55 ± 1.600 and 4.82 ± 1.400 in micro-molar on liver, cervical and breast cancer cell lines, respectively.

  14. Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML

    PubMed Central

    2012-01-01

    Background WASP family proteins stimulate the actin-nucleating activity of the ARP2/3 complex. They include members of the well-known WASP and WAVE/Scar proteins, and the recently identified WASH and WHAMM proteins. WASP family proteins contain family specific N-terminal domains followed by proline-rich regions and C-terminal VCA domains that harbour the ARP2/3-activating regions. Results To reveal the evolution of ARP2/3 activation by WASP family proteins we performed a "holistic" analysis by manually assembling and annotating all homologs in most of the eukaryotic genomes available. We have identified two new families: the WAML proteins (WASP and MIM like), which combine the membrane-deforming and actin bundling functions of the IMD domains with the ARP2/3-activating VCA regions, and the WAWH protein (WASP without WH1 domain) that have been identified in amoebae, Apusozoa, and the anole lizard. Surprisingly, with one exception we did not identify any alternative splice forms for WASP family proteins, which is in strong contrast to other actin-binding proteins like Ena/VASP, MIM, or NHS proteins that share domains with WASP proteins. Conclusions Our analysis showed that the last common ancestor of the eukaryotes must have contained a homolog of WASP, WAVE, and WASH. Specific families have subsequently been lost in many taxa like the WASPs in plants, algae, Stramenopiles, and Euglenozoa, and the WASH proteins in fungi. The WHAMM proteins are metazoa specific and have most probably been invented by the Eumetazoa. The diversity of WASP family proteins has strongly been increased by many species- and taxon-specific gene duplications and multimerisations. All data is freely accessible via http://www.cymobase.org. PMID:22316129

  15. Glial Cell Line-Derived Neurotrophic Factor Family Members Reduce Microglial Activation via Inhibiting p38MAPKs-Mediated Inflammatory Responses

    PubMed Central

    Rickert, Uta; Grampp, Steffen; Wilms, Henrik; Spreu, Jessica; Knerlich-Lukoschus, Friederike; Held-Feindt, Janka; Lucius, Ralph

    2014-01-01

    Previous studies have shown that glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) are potent survival factors for dopaminergic neurons and motoneurons with therapeutic potential for Parkinson's disease. However, little is known about direct influences of the GFL on microglia function, which are known to express part of the GDNF receptor system. Using RT-PCR and immunohistochemistrym we investigated the expression of the GDNF family receptor alpha 1 (GFR alpha) and the coreceptor transmembrane receptor tyrosine kinase (RET) in rat microglia in vitro as well as the effect of GFL on the expression of proinflammatory molecules in LPS activated microglia. We could show that GFL are able to regulate microglia functions and suggest that part of the well known neuroprotective action may be related to the suppression of microglial activation. We further elucidated the functional significance and pathophysiological implications of these findings and demonstrate that microglia are target cells of members of the GFL (GDNF and the structurally related neurotrophic factors neurturin (NRTN), artemin (ARTN), and persephin (PSPN)). PMID:26317008

  16. 12 CFR 721.4 - How may a credit union apply to engage in an activity that is not preapproved as within a credit...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Secretary of the NCUA Board. NCUA will review your application for completeness and will notify you whether... the Act; (2) Whether the activity is the functional equivalent or logical outgrowth of activities...

  17. 32 CFR 643.116 - Credit unions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Credit unions. 643.116 Section 643.116 National... Additional Authority of Commanders § 643.116 Credit unions. The establishment of credit unions on Army... buildings, without charge for rent or services, to any credit union organized under State law or to...

  18. 32 CFR 643.116 - Credit unions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Credit unions. 643.116 Section 643.116 National... Additional Authority of Commanders § 643.116 Credit unions. The establishment of credit unions on Army... buildings, without charge for rent or services, to any credit union organized under State law or to...

  19. 32 CFR 643.116 - Credit unions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Credit unions. 643.116 Section 643.116 National... Additional Authority of Commanders § 643.116 Credit unions. The establishment of credit unions on Army... buildings, without charge for rent or services, to any credit union organized under State law or to...

  20. 32 CFR 643.116 - Credit unions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Credit unions. 643.116 Section 643.116 National... Additional Authority of Commanders § 643.116 Credit unions. The establishment of credit unions on Army... buildings, without charge for rent or services, to any credit union organized under State law or to...

  1. 32 CFR 643.116 - Credit unions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Credit unions. 643.116 Section 643.116 National... Additional Authority of Commanders § 643.116 Credit unions. The establishment of credit unions on Army... buildings, without charge for rent or services, to any credit union organized under State law or to...

  2. From IDs to Ice Cream to "I, Claudius": Security Is in the Cards at Cleveland Hill Union Free School District.

    ERIC Educational Resources Information Center

    Passmore, Cheryl

    2002-01-01

    Describes the use of plastic identity badges with photographs and barcodes issued to all administrators, teachers, staff members, and students in grades 6-12 at the Cleveland Hill Union Free School District in Cheektowaga, New York. (PKP)

  3. Union certification elections in nursing care facilities.

    PubMed

    Palthe, Jennifer; Deshpande, Satish P

    2003-01-01

    This empirical study examines 387 union certification elections conducted by the National Labor Relations Board in nursing care facilities (North American Industry Classification System 623) from January 1999 to December 2001. Unions won 60% of the elections. Service Employees International Union was involved in 42% of the elections. Bargaining unit size significantly impacted union victory. Unions had a better probability of winning elections in the northeast and midwest than in the south. Unlike other industries, American Federation of Labor-Congress of Industrial Organizations affiliated unions did not suffer a big labor image in nursing care facilities. Implications for union organizers and administrators of nursing care facilities are discussed. PMID:14672442

  4. Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspase-8 activity in H2O2-induced human HUC-F2 fibroblasts

    PubMed Central

    Shimizu, Yuri; Miyakura, Reiko; Otsuka, Yuzuru

    2015-01-01

    Objective: Apoptosis is characterized by distinct morphological and biochemical changes that occur upon activation of a family of serine proteases known as caspases. Reactive oxygen species (ROS) induce apoptosis in many cell systems. Nuclear receptor subfamily 4, group A, member 1 (NR4A1) has been shown to induce apoptosis in a number of cell lineages, but can also paradoxically act as a death inhibitory factor. In the current study, we focused on the potential role of NR4A1 in hydrogen peroxide (H2O2)-induced apoptosis of normal human umbilical cord fibroblast (HUC-F2) cells. Methods: Growth of HUC-F2 cells treated with H2O2 was measured by MTT assay. Analysis of gene expression was performed with a STEP ONE PLUS Real Time PCR system. Inactivation of NR4A1 was treated with siRNA. Apoptosis was measured by Beckman Coulter flow cytometer after inhibition of NR4A1 with siRNA and H2O2 treatment. Caspase -3, -8 and -9 was measured by caspase assay kit. Results: H2O2 treatment led to enhanced NR4A1 expression. Moreover inhibition of NR4A1 with specific siRNA in HUC-F2 cells triggered an increase in apoptosis and caspase-8 and -3 activities following the addition of H2O2. Discussion: Our results collectively suggest that NR4A1 is a regulator that inhibits extrinsic apoptosis in HUC-F2 cells during oxidative stress through reduction of caspase-8 and -3 activities. PMID:25330024

  5. Voxel-wise resting-state MEG source magnitude imaging study reveals neurocircuitry abnormality in active-duty service members and veterans with PTSD

    PubMed Central

    Huang, Ming-Xiong; Yurgil, Kate A.; Robb, Ashley; Angeles, Annemarie; Diwakar, Mithun; Risbrough, Victoria B.; Nichols, Sharon L.; McLay, Robert; Theilmann, Rebecca J.; Song, Tao; Huang, Charles W.; Lee, Roland R.; Baker, Dewleen G.

    2014-01-01

    Post-traumatic stress disorder (PTSD) is a leading cause of sustained impairment, distress, and poor quality of life in military personnel, veterans, and civilians. Indirect functional neuroimaging studies using PET or fMRI with fear-related stimuli support a PTSD neurocircuitry model that includes amygdala, hippocampus, and ventromedial prefrontal cortex (vmPFC). However, it is not clear if this model can fully account for PTSD abnormalities detected directly by electromagnetic-based source imaging techniques in resting-state. The present study examined resting-state magnetoencephalography (MEG) signals in 25 active-duty service members and veterans with PTSD and 30 healthy volunteers. In contrast to the healthy volunteers, individuals with PTSD showed: 1) hyperactivity from amygdala, hippocampus, posterolateral orbitofrontal cortex (OFC), dorsomedial prefrontal cortex (dmPFC), and insular cortex in high-frequency (i.e., beta, gamma, and high-gamma) bands; 2) hypoactivity from vmPFC, Frontal Pole (FP), and dorsolateral prefrontal cortex (dlPFC) in high-frequency bands; 3) extensive hypoactivity from dlPFC, FP, anterior temporal lobes, precuneous cortex, and sensorimotor cortex in alpha and low-frequency bands; and 4) in individuals with PTSD, MEG activity in the left amygdala and posterolateral OFC correlated positively with PTSD symptom scores, whereas MEG activity in vmPFC and precuneous correlated negatively with symptom score. The present study showed that MEG source imaging technique revealed new abnormalities in the resting-state electromagnetic signals from the PTSD neurocircuitry. Particularly, posterolateral OFC and precuneous may play important roles in the PTSD neurocircuitry model. PMID:25180160

  6. An Enzymatically Active β-1,3-Glucanase from Ash Pollen with Allergenic Properties: A Particular Member in the Oleaceae Family

    PubMed Central

    Torres, María; Palomares, Oscar; Quiralte, Joaquín; Pauli, Gabrielle; Rodríguez, Rosalía; Villalba, Mayte

    2015-01-01

    Endo-β-1,3-glucanases are widespread enzymes with glycosyl hydrolitic activity involved in carbohydrate remodelling during the germination and pollen tube growth. Although members of this protein family with allergenic activity have been reported, their effective contribution to allergy is little known. In this work, we identified Fra e 9 as a novel allergenic β-1,3-glucanase from ash pollen. We produced the catalytic and carbohydrate-binding domains as two independent recombinant proteins and characterized them from structural, biochemical and immunological point of view in comparison to their counterparts from olive pollen. We showed that despite having significant differences in biochemical activity Fra e 9 and Ole e 9 display similar IgE-binding capacity, suggesting that β-1,3-glucanases represent an heterogeneous family that could display intrinsic allergenic capacity. Specific cDNA encoding Fra e 9 was cloned and sequenced. The full-length cDNA encoded a polypeptide chain of 461 amino acids containing a signal peptide of 29 residues, leading to a mature protein of 47760.2 Da and a pI of 8.66. An N-terminal catalytic domain and a C-terminal carbohydrate-binding module are the components of this enzyme. Despite the phylogenetic proximity to the olive pollen β-1,3-glucanase, Ole e 9, there is only a 39% identity between both sequences. The N- and C-terminal domains have been produced as independent recombinant proteins in Escherichia coli and Pichia pastoris, respectively. Although a low or null enzymatic activity has been associated to long β-1,3-glucanases, the recombinant N-terminal domain has 200-fold higher hydrolytic activity on laminarin than reported for Ole e 9. The C-terminal domain of Fra e 9, a cysteine-rich compact structure, is able to bind laminarin. Both molecules retain comparable IgE-binding capacity when assayed with allergic sera. In summary, the structural and functional comparison between these two closely phylogenetic related enzymes

  7. The Porcine Chloride Channel Calcium-Activated Family Member pCLCA4a Mirrors Lung Expression of the Human hCLCA4

    PubMed Central

    Plog, Stephanie; Grötzsch, Tanja; Klymiuk, Nikolai; Kobalz, Ursula; Gruber, Achim D.

    2012-01-01

    Pig models of cystic fibrosis (CF) have recently been established that are expected to mimic the human disease closer than mouse models do. The human CLCA (originally named chloride channels, calcium-activated) member hCLCA4 is considered a potential modifier of disease severity in CF, but its murine ortholog, mCLCA6, is not expressed in the mouse lung. Here, we have characterized the genomic structure, protein processing, and tissue expression patterns of the porcine ortholog to hCLCA4, pCLCA4a. The genomic structure and cellular protein processing of pCLCA4a were found to closely mirror those of hCLCA4 and mCLCA6. Similar to human lung, pCLCA4a mRNA was strongly expressed in porcine lungs, and the pCLCA4a protein was immunohistochemically detected on the apical membranes of tracheal and bronchial epithelial cells. This stands in sharp contrast to mouse mCLCA6, which has been detected exclusively in intestinal epithelia but not the murine lung. The results may add to the understanding of species-specific differences in the CF phenotype and support the notion that the CF pig model may be more suitable than murine models to study the role of hCLCA4. PMID:22205680

  8. Mutational Analysis of AREA, a Transcriptional Activator Mediating Nitrogen Metabolite Repression in Aspergillus nidulans and a Member of the “Streetwise” GATA Family of Transcription Factors

    PubMed Central

    Wilson, Richard A.; Arst, Herbert N.

    1998-01-01

    Summary: The transcriptional activator AREA is a member of the GATA family of transcription factors and mediates nitrogen metabolite repression in the fungus Aspergillus nidulans. The nutritional versatility of A. nidulans and its amenability to classical and reverse genetic manipulations make the AREA DNA binding domain (DBD) a useful model for analyzing GATA family DBDs, particularly as structures of two AREA-DNA complexes have been determined. The 109 extant mutant forms of the AREA DBD surveyed here constitute one of the highest totals of eukaryotic transcription factor DBD mutants, are discussed in light of the roles of individual residues, and are compared to corresponding mutant sequence changes in other fungal GATA factor DBDs. Other topics include delineation of the DBD using both homology and mutational truncation, use of frameshift reversion to detect regions of tolerance to mutational change, the finding that duplication of the DBD can apparently enhance AREA function, and use of the AREA system to analyze a vertebrate GATA factor DBD. Some major points to emerge from work on the AREA DBD are (i) tolerance to sequence change (with retention of function) is surprisingly great, (ii) mutational changes in a transcription factor can have widely differing, even opposing, effects on expression of different structural genes so that monitoring expression of one or even several structural genes can be insufficient and possibly misleading, and (iii) a mutational change altering local hydrophobic packing and DNA binding target specificity can markedly influence the behavior of mutational changes elsewhere in the DBD. PMID:9729601

  9. Hyperosmotic stress activates the expression of members of the miR-15/107 family and induces downregulation of anti-apoptotic genes in rat liver

    PubMed Central

    Santosa, David; Castoldi, Mirco; Paluschinski, Martha; Sommerfeld, Annika; Häussinger, Dieter

    2015-01-01

    microRNAs are an abundant class of small non-coding RNAs that negatively regulate gene expression. Importantly, microRNA activity has been linked to the control of cellular stress response. In the present study, we investigated whether the expression of hepatic microRNAs is affected by changes in ambient osmolarity. It is shown that hyperosmotic exposure of perfused rat liver induces a rapid upregulation of miR-15a, miR-15b and miR-16, which are members of the miR-15/107 microRNAs superfamily. It was also identified that hyperosmolarity significantly reduces the expression of anti-apoptotic genes including Bcl2, Ccnd1, Mcl1, Faim, Aatf, Bfar and Ikbkb, which are either validated or predicted targets of these microRNAs. Moreover, through the application of NOX and JNK inhibitors as well as benzylamine it is shown that the observed response is mediated by reactive oxygen species (ROS), suggesting that miR-15a, miR-15b and miR-16 are novel redoximiRs. It is concluded that the response of these three microRNAs to osmotic stress is ROS-mediated and that it might contribute to the development of a proapoptotic phenotype. PMID:26195352

  10. Czech Republic to Become Member of ESO

    NASA Astrophysics Data System (ADS)

    2006-12-01

    Albert Einstein stayed in the famous city for periods of time. The Czech capital also played host to the General Assembly of the International Astronomical Union, first in 1967 and, more recently, in August 2006. Astronomy in the Czech Republic is shared between the Astronomical Institute of the Academy of Sciences and several leading universities, in Prague, Brno and Opava, among others. The Astronomical Institute operates the Ondrejov Observatory, with a 2-m optical telescope and a 10-m radio telescope. Czech astronomers are very active in many fields of this science, such as solar and stellar physics, and the study of interstellar matter, galaxies and planetary systems. Created in 1962, ESO, which quite fittingly means 'ace' in the Czech language, provides state-of-the-art research facilities to European astronomers and astrophysicists. ESO's activities cover a wide spectrum including the design and construction of world-class ground-based observational facilities for the member-state scientists, large telescope projects, design of innovative scientific instruments, developing new and advanced technologies, furthering European co-operation and carrying out European educational programmes. Whilst the Headquarters are located in Garching near Munich, Germany, ESO operates three observational sites in the Chilean Atacama desert. The Very Large Telescope (VLT) is located on Paranal, a 2 600m high mountain south of Antofagasta. At La Silla, 600 km north of Santiago de Chile at 2 400m altitude, ESO operates several medium-sized optical telescopes. The third site is the 5 000m high Llano de Chajnantor, near San Pedro de Atacama. Here a new submillimetre telescope (APEX) is in operation, and a giant array of 12-m submillimetre antennas (ALMA) is under development. Over 1 600 proposals are made each year for the use of the ESO telescopes.

  11. Evidence of flank failure deposit reactivation in a shield volcano. A favorable context for deep-seated landslide activation (La Réunion Island)

    NASA Astrophysics Data System (ADS)

    Belle, Pierre; Aunay, Bertrand; Famin, Vincent; Join, Jean-Lambert

    2014-05-01

    Giant flank failures are recurrent features of shield volcanoes, and their deposits (i.e. breccia), constitute a significant volume in a volcanic edifice. On La Réunion Island, the growth and development of Piton des Neiges volcano has been punctuated by several flank failure episodes. One of these failures is a deep-seated landslide (>200 Mm3) occurring nowadays in Grand Ilet, a plateau inhabited by 1 000 people in the cirque of Salazie, on the northern flank of Piton des Neiges. Here we present the results of a multidisciplinary study (structural geology and field mapping, GNSS monitoring, borehole logging) performed to characterize the geological structure the Grand Ilet landslide, and identify the instability factors that control this category of destabilization. Basic breccia deposits, up to 160 meters thick, constitute the main geological formation of the unstable mass. This breccia are cut by the headwall scar of the landslide, and covered by lava flows, indicating a minimum age of 200 kyr for the destabilization that produced the deposits. The breccia is consolidated out of the landslide area. The NE toe of the landslide is evidenced by an important compressional deformation of the base of the breccia, and striated surfaces in this deformed volume indicate a NE-direction of transport. In this deformed bulge, a clay-rich layer at the base of the breccia has been identified as the main slip plane. Using a video inspection of drill casings on three exploration boreholes, we reconstructed the 3D geometry of the slip plane at the base of the breccia. This reconstruction shows that the landslide plane has an average dip of 6° toward the NE. The displacement monitoring network shows that the unstable mass has a 5.5 km2 extension, with a variable azimuth of movement direction (N140° for the SW sector, and N45° for the NE sector). The planimetric displacements velocities range between 2 cm/year in the inner part of the unstable mass to 52 cm/year at the

  12. FORT UNION DEEP

    SciTech Connect

    Lyle A. Johnson Jr.

    2002-09-01

    Coalbed methane (CBM) is currently the hottest area of energy development in the Rocky Mountain area. The Powder River Basin (PRB) is the largest CBM area in Wyoming and has attracted the majority of the attention because of its high permeability and relatively shallow depth. Other Wyoming coal regions are also being targeted for development, but most of these areas have lower permeability and deeper coal seams. This project consists of the development of a CBM stimulation system for deep coal resources and involves three work areas: (1) Well Placement, (2) Well Stimulation, and (3) Production Monitoring and Evaluation. The focus of this project is the Washakie Basin. Timberline Energy, Inc., the cosponsor, has a project area in southern Carbon County, Wyoming, and northern Moffat County, Colorado. The target coal is found near the top of the lower Fort Union formation. The well for this project, Evans No.1, was drilled to a depth of 2,700 ft. Three coal seams were encountered with sandstone and some interbedded shale between seams. Well logs indicated that the coal seams and the sandstone contained gas. For the testing, the upper seam at 2,000 ft was selected. The well, drilled and completed for this project, produced very little water and only occasional burps of methane. To enhance the well, a mild severity fracture was conducted to fracture the coal seam and not the adjacent sandstone. Fracturing data indicated a fracture half-length of 34 ft, a coal permeability of 0.2226 md, and permeability of 15.3 md. Following fracturing, the gas production rate stabilized at 10 Mscf/day within water production of 18 bpd. The Western Research Institute (WRI) CBM model was used to design a 14-day stimulation cycle followed by a 30-day production period. A maximum injection pressure of 1,200 psig to remain well below the fracture pressure was selected. Model predictions were 20 Mscf/day of air injection for 14 days, a one-day shut-in, then flowback. The predicted flowback

  13. FORT UNION DEEP

    SciTech Connect

    Lyle A. Johnson Jr.

    2002-03-01

    Coalbed methane (CBM) is currently the hottest area of energy development in the Rocky Mountain area. The Powder River Basin (PRB) is the largest CBM area in Wyoming and has attracted the majority of the attention because of its high permeability and relatively shallow depth. Other Wyoming coal regions are also being targeted for development, but most of these areas have lower permeability and deeper coal seams. This project consists of the development of a CBM stimulation system for deep coal resources and involves three work areas: (1) Well Placement, (2) Well Stimulation, and (3) Production Monitoring and Evaluation. The focus of this project is the Washakie Basin. Timberline Energy, Inc., the cosponsor, has a project area in southern Carbon County, Wyoming, and northern Moffat County, Colorado. The target coal is found near the top of the lower Fort Union formation. The well for this project, Evans No.1, was drilled to a depth of 2,700 ft. Three coal seams were encountered with sandstone and some interbedded shale between seams. Well logs indicated that the coal seams and the sandstone contained gas. For the testing, the upper seam at 2,000 ft was selected. The well, drilled and completed for this project, produced very little water and only occasional burps of methane. To enhance the well, a mild severity fracture was conducted to fracture the coal seam and not the adjacent sandstone. Fracturing data indicated a fracture half-length of 34 ft, a coal permeability of 0.2226 md, and permeability of 15.3 md. Following fracturing, the gas production rate stabilized at 10 Mscf/day within water production of 18 bpd. The Western Research Institute (WRI) CBM model was used to design a 14-day stimulation cycle followed by a 30-day production period. A maximum injection pressure of 1,200 psig to remain well below the fracture pressure was selected. Model predictions were 20 Mscf/day of air injection for 14 days, a one-day shut-in, then flowback. The predicted flowback

  14. Analysis of the Role of the Active Site Residue Arg98 in the Flavoprotein Tryptophan 2-Monooxygenase, a Member of the l-Amino Oxidase Family†

    PubMed Central

    Sobrado, Pablo; Fitzpatrick, Paul F.

    2006-01-01

    The flavoprotein tryptophan 2-monooxygenase catalyzes the oxidative decarboxylation of tryptophan to indoleacetamide. We have previously identified tryptophan 2-monooxygenase as a homologue of l-amino acid oxidase [Sobrado, P., and Fitzpatrick, P. F. (2002) Arch. Biochem. Biophys. 402, 24–30]. On the basis of the sequence comparisons of the different LAAO family members, Arg98 of tryptophan 2-monooxygenase can be identified as an active site residue which interacts with the carboxylate of the amino acid substrate. The catalytic properties of R98K and R98A tryptophan 2-monooxygenase have been characterized to evaluate the role of this residue. Mutation of Arg98 to lysine decreases the first-order rate constant for flavin reduction by 180-fold and the second-order rate constant for flavin oxidation by 26-fold, has no significant effect on the Kd value for tryptophan or the Ki value for the competitive inhibitor indoleacetamide, and increases the Ki value for indolepyruvate less than 2-fold. Mutation of this residue to alanine decreases the rate constants for reduction and oxidation an additional 5- and 2-fold, respectively, and increases the Kd value for tryptophan and the Ki value for indolepyruvate by 31- and 17-fold, respectively, while having an only 2-fold effect on the Ki value for indoleacetamide. Both mutations increase the value of the primary deuterium isotope effect with tryptophan as a substrate, consistent with a later transition state. Both mutant enzymes catalyze a simple oxidase reaction, producing indolepyruvate and hydrogen peroxide. The pH dependences of the V/Ktrp values for the mutant enzymes show that the anionic form of the substrate is preferred but that the zwitterionic form is a substrate. The results are consistent with the interaction between Arg98 and the carboxylate of the amino acid substrate being critical for correct positioning of the substrate in the active site for efficient catalysis. PMID:14636049

  15. Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.

    PubMed

    Yamashita-Sugahara, Yzumi; Tokuzawa, Yoshimi; Nakachi, Yutaka; Kanesaki-Yatsuka, Yukiko; Matsumoto, Masahito; Mizuno, Yosuke; Okazaki, Yasushi

    2013-02-15

    This report identifies a novel gene encoding Fam57b (family with sequence similarity 57, member B) as a novel peroxisome proliferator-activated receptor γ (PPARγ)-responsive transmembrane gene that is related to obesity. The gene was identified based on an integrated bioinformatics analysis of the following three expression profiling data sets: adipocyte differentiation of mouse stromal cells (ST2 cells), adipose tissues from obesity mice, and siRNA-mediated knockdown of Pparγ using ST2 cells. Fam57b consists of three variants expressed from different promoters and contains a Tram-Lag1-CLN8 domain that is related to ceramide synthase. Reporter and ChIP assays showed that Fam57b variant 2 is a bona fide PPARγ target gene in ST2 cells. Fam57b was up-regulated during adipocyte differentiation, suggesting that FAM57B is involved in this process. Surprisingly, FAM57B overexpression inhibited adipogenesis, and siRNA-mediated knockdown promoted adipocyte differentiation. Analysis of the ceramide content by lipid assay found that ceramides were in fact augmented in FAM57B-overexpressing ST2 cells. We also confirmed that ceramide inhibits adipogenesis. Therefore, the aforementioned results of FAM57B overexpression and siRNA experiments are reconciled by ceramide synthesis. In summary, we present in vitro evidence showing that PPARγ regulates Fam57b transcription during the adipogenesis of ST2 cells. In addition, our results suggest that PPARγ activation contributes to the regulation of ceramide metabolism during adipogenesis via FAM57B. PMID:23275342

  16. Results of community deliberation about social impacts of ecological restoration: comparing public input of self-selected versus actively engaged community members.

    PubMed

    Harris, Charles C; Nielsen, Erik A; Becker, Dennis R; Blahna, Dale J; McLaughlin, William J

    2012-08-01

    Participatory processes for obtaining residents' input about community impacts of proposed environmental management actions have long raised concerns about who participates in public involvement efforts and whose interests they represent. This study explored methods of broad-based involvement and the role of deliberation in social impact assessment. Interactive community forums were conducted in 27 communities to solicit public input on proposed alternatives for recovering wild salmon in the Pacific Northwest US. Individuals identified by fellow residents as most active and involved in community affairs ("AE residents") were invited to participate in deliberations about likely social impacts of proposed engineering and ecological actions such as dam removal. Judgments of these AE participants about community impacts were compared with the judgments of residents motivated to attend a forum out of personal interest, who were designated as self-selected ("SS") participants. While the magnitude of impacts rated by SS participants across all communities differed significantly from AE participants' ratings, in-depth analysis of results from two community case studies found that both AE and SS participants identified a large and diverse set of unique impacts, as well as many of the same kinds of impacts. Thus, inclusion of both kinds of residents resulted in a greater range of impacts for consideration in the environmental impact study. The case study results also found that the extent to which similar kinds of impacts are specified by AE and SS group members can differ by type of community. Study results caution against simplistic conclusions drawn from this approach to community-wide public participation. Nonetheless, the results affirm that deliberative methods for community-based impact assessment involving both AE and SS residents can provide a more complete picture of perceived impacts of proposed restoration activities. PMID:22615108

  17. Results of Community Deliberation About Social Impacts of Ecological Restoration: Comparing Public Input of Self-Selected Versus Actively Engaged Community Members

    NASA Astrophysics Data System (ADS)

    Harris, Charles C.; Nielsen, Erik A.; Becker, Dennis R.; Blahna, Dale J.; McLaughlin, William J.

    2012-08-01

    Participatory processes for obtaining residents' input about community impacts of proposed environmental management actions have long raised concerns about who participates in public involvement efforts and whose interests they represent. This study explored methods of broad-based involvement and the role of deliberation in social impact assessment. Interactive community forums were conducted in 27 communities to solicit public input on proposed alternatives for recovering wild salmon in the Pacific Northwest US. Individuals identified by fellow residents as most active and involved in community affairs ("AE residents") were invited to participate in deliberations about likely social impacts of proposed engineering and ecological actions such as dam removal. Judgments of these AE participants about community impacts were compared with the judgments of residents motivated to attend a forum out of personal interest, who were designated as self-selected ("SS") participants. While the magnitude of impacts rated by SS participants across all communities differed significantly from AE participants' ratings, in-depth analysis of results from two community case studies found that both AE and SS participants identified a large and diverse set of unique impacts, as well as many of the same kinds of impacts. Thus, inclusion of both kinds of residents resulted in a greater range of impacts for consideration in the environmental impact study. The case study results also found that the extent to which similar kinds of impacts are specified by AE and SS group members can differ by type of community. Study results caution against simplistic conclusions drawn from this approach to community-wide public participation. Nonetheless, the results affirm that deliberative methods for community-based impact assessment involving both AE and SS residents can provide a more complete picture of perceived impacts of proposed restoration activities.

  18. Incidence of Campylobacter infections among service members of the active and reserve components of the U.S. Armed Forces and among other beneficiaries of the Military Health System, 2000-2013.

    PubMed

    2014-12-01

    This report reviews the incidence of illness due to Campylobacter bacteria based on diagnoses recorded in healthcare records and reported through the Armed Forces reportable medical event (RME) system. During 2000-2013, incident cases of Campylobacter infection were diagnosed in 1,393 active component service members, 188 members of the reserve component, and 3,891 retirees and family members. Among members of the active component, incidence rates tended to be higher among females, those aged 40 years or older, members of the Army and Air Force, and offi cers. Incidence rates declined from 2002 through 2007 but have risen steadily since, especially from 2010 through 2013. Among retirees and family members, the highest numbers of cases were diagnosed among those aged 5 years or younger and those aged 75 years or older. Cases identifi ed through RME reports (n=2,938) showed the highest numbers of cases in May-August, especially July, and that cases reported from Fort Shafter, HI, accounted for 20% of all cases. Measures and precautions important in preventing Campylobacter infections as well as other food- and waterborne infections are discussed. PMID:25555210

  19. Diagnosis of union of distal tibia fractures: accuracy and interobserver reliability.

    PubMed

    van Kollenburg, Johan A P A C; Vrahas, Mark S; Smith, R Malcolm; Guitton, Thierry G; Ring, David

    2013-08-01

    Decisions about return to activity and additional surgery are often made on the basis of radiographs obtained 3 months after injury. If radiographs 3 months after injury cannot reliably and accurately diagnose union, then patients may be needlessly disabled and might receive unnecessary treatments including surgery. We evaluated the accuracy and the reliability of the diagnosis of union or eventual union on radiographs obtained 3 months after open reduction and internal fixation of a fracture of the distal tibia by having 69 trauma surgeons evaluate radiographs of 33 consecutively treated patients in an online survey. Observers were also asked to judge specific criteria that are commonly used to diagnose fracture union. There was moderate interobserver reliability for the diagnosis of union or diagnosis of "eventual union". The interobserver agreement for the various specific radiographic signs of union varied between fair to moderate. The sensitivity of radiographs for diagnosis of "union or eventual union" of distal tibia fractures was 47%, the specificity was 73% and the accuracy was 68%. The prevalence adjusted positive predictive value was 25% and the negative predictive value was 88%. Diagnosis of union based on radiographs 3 months after injury is only moderately reliable and accurate but has a high negative predictive value. Decisions about activity level and additional treatment 3 months after injury should not be based on radiographs alone. PMID:23200031

  20. Staff Members as Lifelong Learners.

    ERIC Educational Resources Information Center

    Stern, Joanne V.

    Based on the assumption that all community college staff members should be lifelong learners, this paper outlines the purposes and principles underlying a quality staff development program and enumerates the elements, activities, incentives, and other considerations that are necessary for the program to be successful. First, the purposes of staff…

  1. Professional nurses in unions: working together pays off.

    PubMed

    Breda, K L

    1997-01-01

    Professionalism versus unionization of nurses is often posited as a dichotomy of mutually exclusive choices. Many US nurses are alienated from militancy and activism because they are viewed as unprofessional. This stance weakens nurses' ability to organize coalitions, to increase their power bases, and to advocate for both nurses and clients. This article examines how nurses worked together in a labor union to realize professional gains. Ethnography, including participant observation and ethnographic interviews, was the method used to study unionized registered nurses (RNs) in a 60-bed, private, not-for-profit psychiatric hospital in rural southern New England. The union nurses' position as workers in a gendered profession was analyzed. Nurses' union involvement, solidarity, and working conditions were considered in the context of a patriarchal and authoritarian hospital setting. Collaborative decision making and an innovative conflict resolution strategy allowed nurses to voice professional concerns. Unionization allowed RNs to collectively mobilize as a legitimate ideological force in the hospital culture and to enhance their professional status. Their ability to resolve conflicts and to implement change within this context were evaluated. PMID:9094836

  2. Explosive activity of the summit cone of Piton de la Fournaise volcano (La Réunion island): A historical and geological review

    NASA Astrophysics Data System (ADS)

    Michon, Laurent; Di Muro, Andrea; Villeneuve, Nicolas; Saint-Marc, Cécile; Fadda, Pierluigi; Manta, Fabio

    2013-08-01

    Summit explosive activity and collapses that form pit craters and calderas represent major volcanic hazards on a dominantly effusive, frequently active volcano like Piton de la Fournaise. Only three summit collapse events (1986, 2002, 2007) have been recorded since the foundation of the Piton de la Fournaise volcano observatory (OVPF) in 1979, and two of them (1986 and 2007) were associated with weak phreatic activity. At Piton de la Fournaise, the normal explosive activity consists of short-lived and mild (< 20 m-high) lava fountains, which quickly evolve into strombolian activity during the eruptions. Based on comprehensive literature review and high-resolution image analysis of surface outcrops and summit caldera walls, we reconstructed the time distribution of recent explosive events (phreatomagmatic; phreatic) and their link with summit collapses and lateral (flank) effusive eruptions. In historical time (post-1640 CE), we recognise two main clusters of explosive events. Frequent and violent phreatomagmatic to phreatic explosions occurred during the oldest cluster (1708-1878) and alternated with long-lasting periods (years to decades) of summit effusive activity. In contrast, scarce, and on average, weak explosions occurred during the youngest cluster (1897-2012), when discrete and short-lived (< 6 months) effusive eruptions represent the main eruptive dynamics. Historical summit collapses (pit craters and caldera), all localised at the top of the summit cone, were related to voluminous lateral eruptions and were followed by a significant decrease in eruptive rate. However, magma draining during lateral eruptions was not systematically associated with summit collapses or explosions. The long-lasting occurrence of magma at very shallow depth below the volcano summit, followed by a rapid lateral drainage, apparently represents a critical condition favouring magma-groundwater interaction to produce explosive activity. The prehistoric growth of the Piton de la

  3. Think Tank Report. The Time is Right for Telling the Union's Story.

    ERIC Educational Resources Information Center

    ACU-I Bulletin, 1991

    1991-01-01

    This report presents the viewpoints and arguments made during a meeting of higher education administrators who were assembled to discuss how college unions and student activities contribute to a sense of community on campus. The report compares how the union and activities profession views itself with how others perceive it, as well as relating…

  4. Art in the Union. College Unions at Work.

    ERIC Educational Resources Information Center

    Moore, Norman F.

    This booklet provides the technical information necessary in handling exhibits of paintings, prints, sculpture, tapestries, and artifacts of interest and value to students. It was published in response to widespread interest, by college union staff and students, in the development of good art exhibit programs and permanent art collections. The…

  5. Eastern Europe: Former Soviet Union, Humpty Dumpty still on its fall. [Petroleum and natural gas exploration and development in the former Soviet Union

    SciTech Connect

    Khartukov, E.M. ); Vinogradova, O.V.

    1993-08-01

    This paper reviews the oil and gas exploration and development activities in the former Soviet Union on a republic by republic basis. It gives figures on new well drilling activities (footage and numbers of new wells), locations of this activity, and production. The paper concentrates on the effects of the Soviet Union break-up on the availability of supplies and markets and the associated logistical headaches which resulted. The paper also briefly discusses activities in Bulgaria, Czech Republic, and Slovenia.

  6. ESU Activity Report 2009

    ERIC Educational Resources Information Center

    European Students' Union (NJ1), 2009

    2009-01-01

    This report tells a short story of European Students' Union (ESU's) work in 2009. It highlights some of the key areas that ESU worked on, while giving some examples of each general area as outlined in the Plan of Work adopted by the ESU members--National Unions of Students--in November 2008. Members have linked to relevant web documents and…

  7. Scientific research in the Soviet Union

    SciTech Connect

    Mtingwa, S.K.

    1990-03-19

    I report on the scientific aspects of my US/USSR Interacademy Exchange Visit to the Soviet Union. My research was conducted at three different institutes: the Lebedev Physical Institute in Moscow, the Leningrad Nuclear Physics Institute in Gatchina, and the Yerevan Physics Institute in Soviet Armenia. I included relevant information about the Soviet educational system, salaries of Soviet physicists, work habits and research activities at the three institutes, and the relevance of that research to work going on in the United States. 18 refs.

  8. The link between multistep magma ascent and eruption intensity: examples from the recent activity of Piton de la Fournaise (La Réunion Island).

    NASA Astrophysics Data System (ADS)

    Di Muro, Andrea

    2014-05-01

    Caldera collapses represent catastrophic events, which induce drastic modification in a volcano plumbing system and can result in major and fast evolution of the system dynamics. At Piton de la Fournaise (PdF) volcano, the 2007 eruptive sequence extruded the largest lava volume (240 Mm3) since at least 3 centuries, provoking the collapse of a small (1 km wide; 340 m deep) summit caldera. In about 35 days, the 2007 major eruption generated i) the greatest lava output rate, ii) the strongest lava fountaining activity (> 200 m high), iii) the largest SO2 volume (> 230 kt) ever documented at PdF. This event ended a 9 year-long period (1998-2007) of continuous edifice inflation and sustained eruptive activity (3 eruptions per year on average). Unexpectedly and in spite of the large volume of magma erupted in 2007, volcano unrest and eruptive activity resumed quickly in 2008, soon after caldera collapse, and produced several closely spaced intracaldera eruptions and shallow intrusions. The post-2007 activity is associated with a trend of continuous volcano deflation and consists in small-volume (<3 Mm3) weak (< 20 m high fountains; strombolian activity) summit/proximal eruptions of moderate/low MgO magmas and frequent shallow magma intrusions. Non-eruptive tremor and increase in SO2 emissions were interpreted as evidences of magma intrusions at shallow depth (< 2.0 km) preceding the eruptions. The 2007-2011 phase of activity represents an ideal case-study to analyze the influence of magma ascent kinetics on the evolution of volcano dynamics at a persistently active basaltic volcano. In order to track magma storage and ascent, we compare geochemical data on fast quenched glasses (melt inclusions, Pele's hairs, coarse ash fragments produced by lava-sea water interaction, glassy crust of lavas, high-temperature lavas quenched in water, matrix glasses) with the geophysical record of volcano unrest. Petro-chemical data suggest that the shallow PdF plumbing system is formed by

  9. "Parent Unions" Join Policy Debates

    ERIC Educational Resources Information Center

    Cavanagh, Sean

    2012-01-01

    Whether they're organizing events, buttonholing legislators, or simply trading ideas and information, a growing number of "parent unions" are attempting to stake out a place in policy debates over education in states and districts, amid a crowded field of actors and advocates. As the term implies, some of these organizations see themselves as…

  10. Are Unions Good for Professors?

    ERIC Educational Resources Information Center

    Aronowitz, Stanley

    1998-01-01

    As in other industries, expansion of part-time work has profoundly affected salaries and working conditions of full-time faculty and staff at many colleges. If public higher education is to survive the influences of privatization, vocationalization, and downsizing, faculty unions, having established a place in the academy, must become more heavily…

  11. Unionization among College Faculty--1989.

    ERIC Educational Resources Information Center

    Douglas, Joel M., Ed.

    1989-01-01

    An analysis of data concerning unionization among college faculty during 1988 is presented. The following topics are discussed: (1) agents elected; (2) American Federation of Teachers; (3) National Education Association; (4) American Association of University Professors; (5) "no-agent" elections; (6) decertifications; (7) strikes; (8) legislation;…

  12. Beyond Unions and Collective Bargaining.

    ERIC Educational Resources Information Center

    Troy, Leo

    2000-01-01

    Analyzes the reasons for decline of union representation to 9% of private sector workers. Suggests that workplace conditions and labor legislation designed to foster collective voice also sustain the individual system of representation, which is consistent with the philosophy of an open society. (SK)

  13. Positive fast sealing union connections

    NASA Technical Reports Server (NTRS)

    Kleber, C. M.

    1972-01-01

    Union connections are designed for connecting high pressure flexible hoses from gas storage manifolds to gas transport trailers. Connection uses O ring seals which can be quickly assembled and disassembled without use of wrenches, and which do not twist hose. Worn or damaged O rings are easily replaced.

  14. Collapsable seal member

    SciTech Connect

    Sherrell, Dennis L.

    1990-01-01

    A hollow, collapsable seal member normally disposed in a natural expanded state offering fail-safe pressure sealing against a seating surface and adapted to be evacuated by a vacuum force for collapsing the seal member to disengage the same from said seating surface.

  15. Collapsable seal member

    SciTech Connect

    Sherrell, D.L.

    1983-12-08

    A hollow, collapsable seal member normally disposed in a natural expanded state offering fail-safe pressure sealing against a seating surface and adapted to be evacuated by a vacuum force for collapsing the seal member to disengage the same from said seating surface.

  16. The New Political Economy of Health Care in the European Union: The Impact of Fiscal Governance.

    PubMed

    Greer, Scott L; Jarman, Holly; Baeten, Rita

    2016-01-01

    We argue that the political economy of health care in the European Union is being changed by the creation of a substantial new apparatus of European fiscal governance. A series of treaties and legal changes since 2008 have given the European Union new powers and duties to enforce budgetary austerity in the member states, and this apparatus of fiscal governance has already extended to include detailed and sometimes coercive policy recommendations to member states about the governance of their health care systems. We map the structures of this new fiscal governance and the way it purports to affect health care decision making. PMID:27076653

  17. Genome-wide identification and expression analysis of the mitogen-activated protein kinase gene family from banana suggest involvement of specific members in different stages of fruit ripening.

    PubMed

    Asif, Mehar Hasan; Lakhwani, Deepika; Pathak, Sumya; Bhambhani, Sweta; Bag, Sumit K; Trivedi, Prabodh Kumar

    2014-03-01

    Mitogen-activated protein kinases (MAPKs) are important components of the tripartite mitogen-activated protein kinase signaling cascade and play an important role in plant growth and development. Although members of the MAPK gene family have been identified in model plants, little information is available regarding this gene family in fruit crops. In this study, we carried out a computational analysis using the Musa Genome database to identify members of the MAPK gene family in banana, an economically important crop and the most popular fruit worldwide. Our analysis identified 25 members of the MAP kinase (MAPK or MPK) gene family. Phylogenetic analyses of MPKs in Arabidopsis, Oryza, and Populus have classified these MPKs into four subgroups. The presence of conserved domains in the deduced amino acid sequences, phylogeny, and genomic organization strongly support their identity as members of the MPK gene family. Expression analysis during ethylene-induced banana fruit ripening suggests the involvement of several MPKs in the ethylene signal transduction pathway that are necessary for banana fruit ripening. Analysis of the cis-regulatory elements in the promoter regions and the involvement of the identified MPKs in various cellular processes, as analyzed using Pathway Studio, suggest a role for the banana MPK gene family in diverse functions related to growth, development, and the stress response. This report is the first concerning the identification of members of a gene family and the elucidation of their role in various processes using the Musa Genome database. PMID:24275941

  18. Partnership Creates Centre for Union Studies

    ERIC Educational Resources Information Center

    Smart, Carol; Roman, Stephen

    1978-01-01

    A unique cooperative venture between the city of Coventry and local trade unions is establishing a library collection of books, periodicals, historical documents, tapes, and films dealing with unions, labor studies, and industrial problems. (JAB)

  19. Apprenticeship in the EU Member States. A Comparison. CEDEFOP Document. First Edition.

    ERIC Educational Resources Information Center

    Ni Cheallaigh, Martina

    A study compared a number of features of apprenticeships in the 12 Member States of the European Union. The study showed that the apprentice contract or indenture has become an integral part of apprenticeship in all Member States. Admissions requirements for access to apprenticeshp, in general, are not high. Although it was an option open to those…

  20. EU Rural Development Policy in the New Member States: Promoting Multifunctionality?

    ERIC Educational Resources Information Center

    Ramniceanu, Irina; Ackrill, Robert

    2007-01-01

    European Union (EU) enlargement has seen 10 new member states (NMS) adopt the full range of EU policies. Within this, the rural development arm of the Common Agricultural Policy offers particular points of interest. Member states chose from an extensive list of policy measures developed within the EU15 and intended, in particular, to…

  1. Proportionate mortality among unionized construction operating engineers.

    PubMed

    Stern, F; Haring-Sweeney, M

    1997-07-01

    This report presents the results of proportionate mortality ratios (PMR) and proportionate cancer mortality ratios (PCMR) among 15,843 members of the International Union of Operating Engineers who had died between 1988-1993. Operating engineers represent one of the 15 unions in the Building and Construction Trades Department and are responsible for the operation and maintenance of heavy earthmoving equipment used in the construction of buildings, bridges, roads, and other facilities. Using U.S. proportionate cancer mortality as the referent, statistically significant elevated mortality was observed for cancers of the lung (PCMR = 1.14, 95% confidence interval (CI) = 1.09-1.19) and bone (PCMR = 2.14, CI = 1.19-3.52). Using U.S. proportionate mortality as the referent, statistically significant elevated mortality was observed for other benign and unspecified neoplasms (PMR = 1.54, CI = 1.09-2.13), emphysema (PMR = 1.37, CI = 1.20-1.55), other injuries (PMR = 1.43, CI = 1.20-1.70) (which included crushing under/in machinery, tractor rollover, run over by crane), and suicide (PMR = 1.22, CI = 1.06-1.40). The PMR for leukemia, and aleukemia (PMR = 1.19, CI = 1.02-1.37), but not the PCMR (1.07, CI = 0.92-1.24), was also significantly elevated. Some of the occupational exposures that may have contributed to these excesses include diesel exhaust, asphalt and welding fumes, silica dust, ionizing radiation, and coal tar pitch. The present study underscores the need to control airborne exposures to these substances and for injury prevention efforts aimed at operating engineers in the construction industry. PMID:9131212

  2. 22 CFR 124.16 - Special retransfer authorizations for unclassified technical data and defense services to member...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Japan, New Zealand, and Switzerland. 124.16 Section 124.16 Foreign Relations DEPARTMENT OF STATE... NATO and the European Union, Australia, Japan, New Zealand, and Switzerland. The provisions of § 124.8... countries that are members of NATO the European Union, Australia, Japan, New Zealand, and Switzerland...

  3. Teacher Union Contracts and High School Reform

    ERIC Educational Resources Information Center

    Price, Mitch

    2009-01-01

    Are teachers unions and collective bargaining agreements barriers to high school reform and redesign efforts in Washington, California, and Ohio? The short answer: sometimes, but not as often as many educators seem to think. Rather than wade into the pro- versus anti-union debate, this report instead aims to offer guidance for educators, unions,…

  4. Unionizing: A Guide for Child Care Workers.

    ERIC Educational Resources Information Center

    Whitebook, Marcy; And Others

    Including excerpts from contracts protecting unionized child care workers, this booklet explains basic terminology and facts about unionizing and addresses child care workers' concerns. Section 1 answers commonly asked questions about unions and offers advice about how to answer parents' questions about workers' attempts to organize. Section 2…

  5. Is There a New Teacher Unionism?

    ERIC Educational Resources Information Center

    Urban, Wayne J.

    1991-01-01

    Discusses new teacher unionism, exploring the impact of significant forces of change on U.S. education in programs, structure, and functions of teacher unions; examines Kerchner and Mitchell's "The Changing Idea of a Teachers' Union" and notes the importance of political and historical context. (SM)

  6. Canadian Teacher Unions: A Comparative Perspective.

    ERIC Educational Resources Information Center

    Smaller, Harry

    1998-01-01

    Presents a history of teacher unionism in Canada, comparing it to the development of teacher unionism in the United States. Union membership was mandated, although teachers had (and still have) little power except that related to professional misconduct. Recently, structural changes have included the introduction of a provincially-legislated…

  7. New Unionism and Over-Managed Professors.

    ERIC Educational Resources Information Center

    Rhoades, Gary

    2000-01-01

    Discussion of higher education faculty and unions urges a "public professional unionism" in which faculty and staff work cooperatively with administrators to promote quality in instruction and a high level of professionalism through participative decision making. Argues that higher education unions must also pay more attention in collective…

  8. Unions and Job Satisfaction: An Alternative View.

    ERIC Educational Resources Information Center

    Pfeffer, Jeffrey; Davis-Blake, Alison

    1990-01-01

    The dominant theoretical perspective suggests that unions reduce job satisfaction by making workers more critical of the workplace and more willing to complain. However, unions reduce wage inequality and increase worker control and commitment. A survey of 978 workers shows that unionization has a positive effect on job satisfaction. (JOW)

  9. Are Charter School Unions Worth the Bargain?

    ERIC Educational Resources Information Center

    Price, Mitch

    2011-01-01

    About 12 percent of all charter schools have bargaining agreements. Why do charter schools unionize? What is in these charter school contracts? Can they be considered innovative or models for union reform? And how do they compare to traditional district/union teacher contracts? Center on Reinventing Public Education legal analyst Mitch Price…

  10. The Implementation of the Greek Union Catalog.

    ERIC Educational Resources Information Center

    Katsirikou, Anthi

    This paper is based on the results of the study of the Work Group of Bibliographic Standards for the Greek union catalog, the first stage of Greek academic library union catalog development. The first section lists the objectives of the union catalog. The state of the art of Greek academic libraries is discussed in the second section. The lack of…

  11. Teacher Unionism as Mission and Battle; Success and Crisis in French Teacher Unions.

    ERIC Educational Resources Information Center

    Fowler, Frances C.

    In France, the National Education Federation (Federation d'Education Nationale (FEN)) and its major constituent union, the National Union of Elementary and Middle School Teachers (Syndicat National des Instituteurs et des Professeurs d'Enseignment General de College (SNI-PEGC)), are examples of "intelligent trade unions," i.e., unions that hold a…

  12. The Economics of Perception: Potential Effect regarding Institutional Uses of Recovered Facilities and Administrative Costs upon a Faculty Member's Decision to Engage in Sponsored Research Activity

    ERIC Educational Resources Information Center

    Hatfield, Anne Elizabeth

    2012-01-01

    There is one aspect of sponsored research associated with higher education's research enterprise that often places the institution's research administrators and the institution's faculty members in conflict with each other; the recovery of Facilities and Administrative (F&A) costs associated with sponsored research projects (Sedwick, 2009;…

  13. Increasing Marital Satisfaction as a Resilience Factor among Active Duty Members and Veterans of Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF)

    ERIC Educational Resources Information Center

    Ponder, Warren N.; Aguirre, Regina T. P.; Smith-Osborne, Alexa; Granvold, Donald K.

    2012-01-01

    Supportive relationships are protective against a number of prevalent health risks among military populations, including post-traumatic stress disorder. Increasing marital satisfaction and strengthening that relationship is an important avenue for maintaining health among returning service members and their families. The current study builds upon…

  14. 75 FR 57820 - National Credit Union Administration Restoration Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... ADMINISTRATION National Credit Union Administration Restoration Plan AGENCY: National Credit Union Administration (NCUA). ACTION: Approval of National Credit Union Administration restoration plan. On September 16, 2010, the National Credit Union Administration (NCUA) implemented a Restoration Plan for the National...

  15. 40. August, 1970 VIEW OF UNION STREET WITH ELISHA GREEN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    40. August, 1970 VIEW OF UNION STREET WITH ELISHA GREEN HOUSE (9 UNION STREET) AT LEFT - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

  16. AGU lost members

    NASA Astrophysics Data System (ADS)

    Mail to the following members has been returned, and we are unable to locate forwarding addresses. If you have information on any of them, please contact AGU by mail or call toll free at 800-424-2488.

  17. Gender and Trade Unions. Gender and Society: Feminist Perspectives on the Past and Present Series.

    ERIC Educational Resources Information Center

    Lawrence, Elizabeth

    This book explores the impact of work and gender roles on union activism in the context of male and female shop stewards in Sheffield National and Local Government Officers' Association (NALGO). An introductory chapter outlines the main themes. Chapter 2 provides a literature review of women's position in trade unions and theories of union…

  18. On the Shopfloor: Exploring the Impact of Teacher Trade Unions on School-Based Industrial Relations.

    ERIC Educational Resources Information Center

    Stevenson, Howard

    2003-01-01

    Explores extent to which devolved management is drawing school-based union representatives into a more prominent role. Argues that while there can be significant differences between individual schools, increased school autonomy is raising the profile of trade union activity in the workplace, and this needs to be better reflected in educational…

  19. 33 CFR 5.25 - Honorary members.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Honorary members. 5.25 Section 5.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL COAST GUARD AUXILIARY § 5.25 Honorary members. For conspicuous service to or active interest in the Auxiliary,...

  20. Manufacturing Dissent: Labor Revitalization, Union Summer and Student Protest

    ERIC Educational Resources Information Center

    Van Dyke, Nella; Dixon, Marc; Carlon, Helen

    2007-01-01

    During the late 1990s, college students across the United States mobilized around labor issues. Our research explores whether this explosion of student protest activity was generated, in part, by concerted efforts of the AFL-CIO through its Union Summer college student internship program. A statistical analysis of factors influencing the location…

  1. Visa Problems and Study Tours of the Soviet Union.

    ERIC Educational Resources Information Center

    Winokur, Marshall

    1981-01-01

    Describes the "study tour of the Soviet Union," for several years a feature of the three-week interim term at the University of Alabama, Tuscaloosa. Discusses tour organization, related orientation activities and itineraries, dwelling at length on problems encountered, especially recent last-minute denials of visa to group leaders. (MES)

  2. Sexual Frequency and the Stability of Marital and Cohabiting Unions

    ERIC Educational Resources Information Center

    Yabiku, Scott T.; Gager, Constance T.

    2009-01-01

    Prior research found that lower sexual frequency and satisfaction were associated with higher rates of divorce, but little research had examined the role of sexual activity in the dissolution of cohabiting unions. We drew upon social exchange theory to hypothesize why sexual frequency is more important in cohabitation: (a) cohabitors' lower costs…

  3. 12 CFR 741.222 - Credit union service organizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Credit union service organizations. 741.222 Section 741.222 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.222 Credit union...

  4. 12 CFR 741.222 - Credit union service organizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Credit union service organizations. 741.222 Section 741.222 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.222 Credit union...

  5. 12 CFR 741.222 - Credit union service organizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Credit union service organizations. 741.222 Section 741.222 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.222 Credit union...

  6. 12 CFR 741.222 - Credit union service organizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Credit union service organizations. 741.222 Section 741.222 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.222 Credit union...

  7. 12 CFR 704.19 - Wholesale corporate credit unions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Wholesale corporate credit unions. 704.19 Section 704.19 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS CORPORATE CREDIT UNIONS § 704.19 Wholesale corporate credit unions. (a) General. Wholesale corporate credit unions are subject to the...

  8. An evolutionary inspection game with labour unions on small-world networks

    NASA Astrophysics Data System (ADS)

    Kamal, Salahuddin M.; Al-Hadeethi, Yas; Abolaban, Fouad A.; Al-Marzouki, Fahd M.; Perc, Matjaž

    2015-03-01

    We study an evolutionary inspection game where agents can chose between working and shirking. The evolutionary process is staged on a small-world network, through which agents compare their incomes and, based on the outcome, decide which strategy to adopt. Moreover, we introduce union members that have certain privileges, of which the extent depends on the bargaining power of the union. We determine how the union affects the overall performance of the firm that employs the agents, and what are its influences on the employees. We find that, depending on its bargaining power, the union has significant leverage to deteriorate the productivity of a firm, and consequently also to lower the long-run benefits of the employees.

  9. Overview of depression, post-traumatic stress disorder, and alcohol misuse among active duty service members returning from Iraq and Afghanistan, self-report and diagnosis.

    PubMed

    Mustillo, Sarah A; Kysar-Moon, Ashleigh; Douglas, Susan R; Hargraves, Ryan; Wadsworth, Shelley MacDermid; Fraine, Melissa; Frazer, Nicole L

    2015-04-01

    Previous studies have found deployment to combat areas to be associated with an increased risk of post-traumatic stress disorder (PTSD), depression, and alcohol abuse, but many previous studies were limited by samples that were not representative of the deployed military as a whole. This study presents an overview of these three mental health problems associated with deployment among Air Force, Army, Marine Corp, and Navy service members returning from deployment to Iraq and Afghanistan between January 2007 and March 2008. With postdeployment health data on over 50,000 service men and women, including diagnostic information, we were able to estimate prevalence of those who screened positive for risk of each disorder in self-report data at two time points, as well as prevalence of diagnoses received during health care encounters within the military health care system. The prevalence ranges of the three disorders were consistent with previous studies using similar measures, but service members in the Navy had higher rates of screening positive for all three disorders and higher prevalence of depression and PTSD diagnoses compared to the other branches. Further, PTSD risk was higher for service members returning from Afghanistan compared to Iraq, in contrast to previous findings. PMID:25826347

  10. Division Xii: Union-Wide Activities

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia L.; Andersen, Johannes; Aksnes, Kaare; Genova, Françoise; Gurshtein, Alexander A.; Johansson, Sveneric; Pasachoff, Jay M.; Smith, Malcolm G.

    2007-12-01

    Division XII consists of Commissions that formerly were organized under the Executive Committee, that concern astronomers across a wide range of scientific sub-disciplines and provide interactions with scientists in a wider community, including governmental organizations, outside the IAU.

  11. Division XII: Union-Wide Activities

    NASA Astrophysics Data System (ADS)

    Smith, Malcolm G.; Genova, Françoise; Andersen, Johannes; Federman, Steven R.; Gilmore, Alan C.; Nha, Il-Seong; Norris, Raymond P.; Robson, Ian E.; Stavinschi, Magda G.; Trimble, Virginia L.; Wainscoat, Richard J.; Christensen, Lars Lindberg

    Division XII consists of Commissions that formerly were organized under the Executive Committee, that concern astronomers across a wide range of scientific sub-disciplines and provide interactions with scientists in a wider community, including governmental organizations, outside the IAU.

  12. 77 FR 16267 - Community Development Revolving Loan Fund Access for Credit Unions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... CDRLF. 12 CFR 705. A revised Part 705 was published on November 2, 2011. 76 FR 67583. Additional... union's marketing strategy to reach members and the community; and include financial projections. 6. Non... funds. However, each Applicant should address in the Application its strategy for raising matching...

  13. Meteorologica, multilanguages Quarterly Journal of Friuli Venezia Giulia Meteorological Union

    NASA Astrophysics Data System (ADS)

    Colucci, R. R.; Stel, F.; Virgilio, M.

    2009-09-01

    The Friuli Venezia Giulia Meteorological Union (UMFVG) is a socially usefull No Profit Organization involved in scientific dissemination of meteorology and climatology. To reach this goal the UMFVG, which involved both profesionists and passionates of weather and climate, organizes conventions, courses, conferences and publishes a quarterly journal, the "Meteorologica” (ISSN 1827-3858). UMFVG is a member of EMS. 8 years have passed since the first edition of the journal, now totally renovated with more pages and topics, part of them translated in 4 languages (Italian, English, Slovenian and German). The "Meteorologica”, edited by the UMFVG, is composed of various columns, some more popular, others more scientific, but all of them with the aim of scientific dissemination to the general public. In the actual last edition of the journal, find place the columns of ARSO of Ljubljana (Slovenia), ZAMG of Klagenfurt (Carintia-Austria) and ARPA OSMER of Udine (Italy), which comment every time the seasonal weather trend. There is also the column of CNR ISMAR, which comments the principal aspects of sea level and sea temperature in the Northern Adriatic. The magazine also host the "Climate Monitor” column edited by Major G.Guidi, forecaster of the Italian Air Force and of RAI television. Last, but not least, there are various deepenings and didactics columns in order to deepen several meteo-climatological themes. The editorial staff have to thank the passion and free will of all of those who actively worked together for the realization of this project if now the thought of delivering "Meteorologica” also in other European countries is not only an ambitious idea but a real objective.

  14. Unions and hospitals: some unresolved issues.

    PubMed

    Adamache, K W; Sloan, F A

    1982-05-01

    This article investigates the impact of unions on the wages of hospital workers. Our OLS findings agree with previous OLS studies--unions increase registered nurses' (RNs) wages by five percent and by about eight to ten percent for other hospital workers. By contrast, we find (after correcting for selectivity bias in hospital unionization status) a direct union effect of about twenty percent on RN wages and in excess of thirty percent on wages of other hospital workers. While the results based on selectivity bias adjustments make us uneasy, we do not reject them out-of-hand. We also find indirect union effects (up to five percent) by other unionized occupations within a hospital and up to ten percent by other unionized hospitals in the local labor market. Prospective reimbursement programs have a negative impact on the wages of hospital workers but are only significant for non-unionized occupations. Our three empirical tests of monopsony all reject the view that monopsony is a factor in hospital wage-setting. Even considering the large union effects (based on selectivity bias adjustment), we conclude that unions have been a minor contributor to hospital cost inflation. PMID:10263950

  15. Stress in service members.

    PubMed

    Lande, R Gregory

    2014-12-01

    Military service differs from civilian jobs in the stressors that service members experience, including frequent deployments (eg, to an area of combat operations), obedience, regimentation, subordination of self to the group, integrity, and flexibility. The military culture emphasizes teamwork and peer support. In some cases, service members cannot adapt to military life, become overwhelmed by stress, or cannot overcome a traumatic experience. Clinicians should conduct a thorough evaluation guided by an understanding of the military culture. Every effort should be made to identify the stress and the maladaptive response and provide early clinical interventions to prevent progression. PMID:25455065

  16. Suicides and suicide attempts among active component members of the U.S. Armed Forces, 2010-2012; methods of self-harm vary by major geographic region of assignment.

    PubMed

    Corr, William P

    2014-10-01

    This report analyzed data from the Department of Defense Suicide Event Report program about suicide events (suicide attempts and suicides) among active component service members during 2010-2012. Most attempts (85.2%) and suicides (83.5%) occurred among service members stationed in the U.S. Drugs were identified as the method of self-harm in 54.8% of attempts but in only 3.6% of suicides. Firearms were the leading method of suicide in both the U.S. and combat zones (61.1% and 97.2%, respectively) but accounted for only 5.4% of suicides in those stationed in Europe/Asia. Hanging/asphyxiation (22.9% overall) was the second most common method in suicides. For suicides using firearms, the rates of suicide and the types of firearm used varied according to service members' geographically related access to firearms. Challenges to reducing the frequency of service member suicides by firearms are discussed. PMID:25357138

  17. Three-Year Follow-Up of Same-Sex Couples Who Had Civil Unions in Vermont, Same-Sex Couples Not in Civil Unions, and Heterosexual Married Couples

    ERIC Educational Resources Information Center

    Balsam, Kimberly F.; Beauchaine, Theodore P.; Rothblum, Esther D.; Solomon, Sondra E.

    2008-01-01

    This study was a 3-year follow-up of 65 male and 138 female same-sex couples who had civil unions in Vermont during the 1st year of that legislation. These couples were compared with 23 male and 61 female same-sex couples in their friendship circles who did not have civil unions and with 55 heterosexual married couples (1 member of each was a…

  18. Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity*

    PubMed Central

    Thomé, Carolina H.; dos Santos, Guilherme A.; Ferreira, Germano A.; Scheucher, Priscila S.; Izumi, Clarice; Leopoldino, Andreia M.; Simão, Ana Maria; Ciancaglini, Pietro; de Oliveira, Kleber T.; Chin, Alice; Hanash, Samir M.; Falcão, Roberto P.; Rego, Eduardo M.; Greene, Lewis J.; Faça, Vitor M.

    2012-01-01

    Lipid rafts are highly ordered membrane domains rich in cholesterol and sphingolipids that provide a scaffold for signal transduction proteins; altered raft structure has also been implicated in cancer progression. We have shown that 25 μm 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate (ODPC), an alkylphospholipid, targets high cholesterol domains in model membranes and induces apoptosis in leukemia cells but spares normal hematopoietic and epithelial cells under the same conditions. We performed a quantitative (SILAC) proteomic screening of ODPC targets in a lipid-raft-enriched fraction of leukemic cells to identify early events prior to the initiation of apoptosis. Six proteins, three with demonstrated palmitoylation sites, were reduced in abundance. One, the linker for activation of T-cell family member 2 (LAT2), is an adaptor protein associated with lipid rafts in its palmitoylated form and is specifically expressed in B lymphocytes and myeloid cells. Interestingly, LAT2 is not expressed in K562, a cell line more resistant to ODPC-induced apoptosis. There was an early loss of LAT2 in the lipid-raft-enriched fraction of NB4 cells within 3 h following treatment with 25 μm ODPC. Subsequent degradation of LAT2 by proteasomes was observed. Twenty-five μm ODPC inhibited AKT activation via myeloid growth factors, and LAT2 knockdown in NB4 cells by shRNA reproduced this effect. LAT2 knockdown in NB4 cells also decreased cell proliferation and increased cell sensitivity to ODPC (7.5×), perifosine (3×), and arsenic trioxide (8.5×). Taken together, these data indicate that LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID:23001822

  19. Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.

    PubMed

    Thomé, Carolina H; dos Santos, Guilherme A; Ferreira, Germano A; Scheucher, Priscila S; Izumi, Clarice; Leopoldino, Andreia M; Simão, Ana Maria; Ciancaglini, Pietro; de Oliveira, Kleber T; Chin, Alice; Hanash, Samir M; Falcão, Roberto P; Rego, Eduardo M; Greene, Lewis J; Faça, Vitor M

    2012-12-01

    Lipid rafts are highly ordered membrane domains rich in cholesterol and sphingolipids that provide a scaffold for signal transduction proteins; altered raft structure has also been implicated in cancer progression. We have shown that 25 μm 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate (ODPC), an alkylphospholipid, targets high cholesterol domains in model membranes and induces apoptosis in leukemia cells but spares normal hematopoietic and epithelial cells under the same conditions. We performed a quantitative (SILAC) proteomic screening of ODPC targets in a lipid-raft-enriched fraction of leukemic cells to identify early events prior to the initiation of apoptosis. Six proteins, three with demonstrated palmitoylation sites, were reduced in abundance. One, the linker for activation of T-cell family member 2 (LAT2), is an adaptor protein associated with lipid rafts in its palmitoylated form and is specifically expressed in B lymphocytes and myeloid cells. Interestingly, LAT2 is not expressed in K562, a cell line more resistant to ODPC-induced apoptosis. There was an early loss of LAT2 in the lipid-raft-enriched fraction of NB4 cells within 3 h following treatment with 25 μm ODPC. Subsequent degradation of LAT2 by proteasomes was observed. Twenty-five μm ODPC inhibited AKT activation via myeloid growth factors, and LAT2 knockdown in NB4 cells by shRNA reproduced this effect. LAT2 knockdown in NB4 cells also decreased cell proliferation and increased cell sensitivity to ODPC (7.5×), perifosine (3×), and arsenic trioxide (8.5×). Taken together, these data indicate that LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID:23001822

  20. Mistakes Board Members Make.

    ERIC Educational Resources Information Center

    Caruso, Nicholas D., Jr.

    2001-01-01

    Board members should avoid 10 common errors: losing patience, behaving badly, challenging the board after a vote, acting like inspectors, micromanaging school administrators, springing surprise questions at meetings, putting politics before children, representing special interests, violating executive session, and putting the board before family…