Science.gov

Sample records for activities appendices include

  1. A Curriculum Activities Guide to Water Pollution and Environmental Studies, Volume II - Appendices.

    ERIC Educational Resources Information Center

    Hershey, John T., Ed.; And Others

    This publication, Volume II of a two volume set of water pollution studies, contains seven appendices which support the studies. Appendix 1, Water Quality Parameters, consolidates the technical aspects of water quality including chemical, biological, computer program, and equipment information. Appendix 2, Implementation, outlines techniques…

  2. DOE standard: Integration of environment, safety, and health into facility disposition activities. Volume 2: Appendices

    SciTech Connect

    1998-05-01

    This volume contains the appendices that provide additional environment, safety, and health (ES and H) information to complement Volume 1 of this Standard. Appendix A provides a set of candidate DOE ES and H directives and external regulations, organized by hazard types that may be used to identify potentially applicable directives to a specific facility disposition activity. Appendix B offers examples and lessons learned that illustrate implementation of ES and H approaches discussed in Section 3 of Volume 1. Appendix C contains ISMS performance expectations to guide a project team in developing and implementing an effective ISMS and in developing specific performance criteria for use in facility disposition. Appendix D provides guidance for identifying potential Applicable or Relevant and Appropriate Requirements (ARARs) when decommissioning facilities fall under the Comprehensive Environmental Response, Compensation, Liability Act (CERCLA) process. Appendix E discusses ES and H considerations for dispositioning facilities by privatization. Appendix F is an overview of the WSS process. Appendix G provides a copy of two DOE Office of Nuclear Safety Policy and Standards memoranda that form the bases for some of the guidance discussed within the Standard. Appendix H gives information on available hazard analysis techniques and references. Appendix I provides a supplemental discussion to Sections 3.3.4, Hazard Baseline Documentation, and 3.3.6, Environmental Permits. Appendix J presents a sample readiness evaluation checklist.

  3. Design verification and fabrication of active control systems for the DAST ARW-2 high aspect ratio wing. Part 2: Appendices

    NASA Technical Reports Server (NTRS)

    Mcgehee, C. R.

    1986-01-01

    This is Part 2-Appendices of a study conducted under Drones for Aerodynamic and Structural Testing (DAST) Program to accomplish the final design and hardware fabrication for four active control systems compatible with and ready for installation in the NASA Aeroelastic Research Wing No. 2 (ARW-2) and Firebee II drone flight test vehicle. The wing structure was designed so that Active Control Systems (ACS) are required in the normal flight envelope by integrating control system design with aerodynamics and structure technologies. The DAST ARW-2 configuration uses flutter suppression, relaxed static stability, and gust and maneuver load alleviation ACS systems, and an automatic flight control system. Performance goals and criteria were applied to individual systems and the systems collectively to assure that vehicle stability margins, flutter margins, flying qualities, and load reductions were achieved.

  4. Improving School Accountability in California. Technical Appendices

    ERIC Educational Resources Information Center

    Larsen, S. Eric; Lipscomb, Stephen; Jaquet, Karina

    2011-01-01

    This paper presents the appendices to the "Improving School Accountability in California" report. Appendices include: (1) Data and Methodology; and (2) Additional Projections. (Contains 1 table, 4 figures and 3 footnotes.) [For the main report, "Improving School Accountability in California," see ED518179.

  5. Special Education Finance in California. Technical Appendices

    ERIC Educational Resources Information Center

    Hill, Laura; Warren, Paul; Murphy, Patrick; Ugo, Iwunze; Pathak, Aditi

    2016-01-01

    This document presents the technical appendices that accompany the full report, "Special Education Finance in California." The appendices include: (1) Problems with AB 602 and Other State Funding Programs for Special Education; (2) Additional Figures for Analysis of Distribution of Students with Disabilities; (3) Using Supplemental and…

  6. SHEDS-Dietary Technical Manual Appendices

    EPA Pesticide Factsheets

    The appendices for the SHEDS-Dietary Technical Manual include a sample food diary, backgorund information on the water concentration data used in SHEDS-Dietary, a food list, food definitions and sample code.

  7. A Curriculum Activities Guide to Water Pollution and Environmental Studies: Activities. Appendices, Volume 1 and Volume 2.

    ERIC Educational Resources Information Center

    Hershey, John T.; And Others

    This activity oriented guide is divided into four sections dealing with the Hydrologic Cycle; Human Activities; Ecological Perspectives; and Social and Political Factors. Each activity contains seven parts: (1) an introduction; (2) questions about the activity; (3) necessary equipment; (4) procedures; (5) results obtained by using the study; (6)…

  8. California's New School Funding Flexibility. Technical Appendices

    ERIC Educational Resources Information Center

    Weston, Margaret

    2011-01-01

    The three appendices herein accompany the main report, "California's New School Funding Flexibility." Included are: (1) California's Previous Flexibility Policies; (2) Data and Methods; and (3) Categorical Funding and Student Disadvantage. (Contains 3 tables and 12 footnotes.) [For "California's New School Funding Flexibility,"…

  9. North Carolina Marine Education Manual: Appendices.

    ERIC Educational Resources Information Center

    Mauldin, Lundie; Frankenberg, Dirk

    Presented are appendices to a series of four manuals of marine education activiLies produced by North Carolina teachers and college faculty under a Sea Grant project entitled "Man and the Seacoast." Information on relevant films, periodicals, federal and state resources, games, and marine careers is provided. Also included are directions for…

  10. Evaluation, engineering and development of advanced cyclone processes. Final separating media evaluation and test report (FSMER). Appendices

    SciTech Connect

    1996-05-01

    This report consists of appendices pertaining to the separating media evaluation (calcium nitrate solution) and testing for an advanced cyclone process. Appendices include: materials safety data, aqueous medium regeneration, pH control strategy, and other notes and data.

  11. Public-Private Ventures for Morale, Welfare, and Recreation Activities. A Solution to the Loss of Appropriated Funds. Volume 7. Appendices O, P, and Q

    DTIC Science & Technology

    1990-07-01

    P, and Q DReport NA705R1 ~DTIC i AUG 31 19908AuG;1io July 1990 Trevor L . Neve Jordan W. Cassell Robert L . Crosslin Robert A. Hutchinson D!B T7rION T 1...of Appropriated Funds (Volumes 1 8)] Trevor L . Neve Robert L . Crosslin C Jordon W. Cassell Robert A. Hutchinson MDA903-85-C-0139 7. P900RANG...Volume 5, Appendices J, K, and L ; Volume 6, Appendices M and N; and Volume 8, Appendices R and S. Accesion For . NTIS CRA&I DTIC TAB 0 Unannot’, iced [] By

  12. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  13. Gastrointestinal Kaposi sarcoma with appendiceal involvement.

    PubMed

    Egwuonwu, Steve; Gatto-Weis, Cara; Miranda, Roberto; Casas, Luis De Las

    2011-04-01

    Kaposi sarcoma is a vascular tumor manifesting as nodular lesions on skin, mucous membranes, or internal organs. This is a case of a 42-year-old human immunodeficiency virus- (HIV) positive bisexual male, not on highly active antiretroviral therapy (HAART) since diagnosis four years ago. He presented with a three-day history of abdominal pains, fever, vomiting, and a one-week history of melena stools. Endoscopy revealed Kaposi sarcoma in the stomach and duodenum. Postendoscopy, he developed acute abdomen. Exploratory laparotomy revealed extensive Kaposi sarcoma of the gastrointestinal tract with appendiceal involvement. The patient underwent appendectomy and had an uneventful recovery. A review of the literature discusses appendiceal Kaposi sarcoma with appendicitis, a rare but critical manifestation of gastrointestinal Kaposi sarcoma.

  14. Technology transfer for the US Department of Energy's Energy Storage Program: Volume 2, Appendices

    SciTech Connect

    Bruneau, C.L.; Fassbender, L.L.

    1988-10-01

    This document contains the appendices to Technology Transfer Recommendations for the US Department of Energy's Storage Program (PNL-6484, Vol. 1). These appendices are a list of projects, publications, and presentations connected with the Energy Storage (STOR) program. In Volume 1, the technology transfer activities of the STOR program are examined and mechanisms for increasing the effectiveness of those activities are recommended.

  15. Low-Income Students and School Meal Programs in California. Technical Appendices

    ERIC Educational Resources Information Center

    Danielson, Caroline

    2015-01-01

    These technical appendices are intended to accompany the study, "Low-Income Students and School Meal Programs in California." Two appendices are included. Appendix A provides tables detailing: (1) the variables included in the main models and the datasets(s) used to construct each; (2) observations in each dataset and categorizes them…

  16. Appendiceal Crohn’s disease clinically presenting as acute appendicitis

    PubMed Central

    Han, Hulin; Kim, Hyunsung; Rehman, Abdul; Jang, Se Min; Paik, Seung Sam

    2014-01-01

    AIM: To determine the incidence of appendiceal Crohn’s disease (CD) and to summarize the characteristic histologic features of appendiceal CD. METHODS: We reviewed the pathology files of 2179 appendectomy specimens from January 2007 to May 2013. The computer-assisted retrieval search facility was utilized to collect specimens. We selected those cases that were diagnosed as CD or chronic granulomatous inflammation and defined the final diagnosis according to the histologic findings of CD, including transmural lymphocytic inflammation, non-caseating epithelioid granulomas, thickening of the appendiceal wall secondary to hypertrophy of muscularis mucosa, mucosal ulceration with crypt abscesses, mucosal fissures, and fistula formation. RESULTS: We found 12 cases (7 male and 5 female patients, with an average age of 29.8 years) of appendiceal CD. The incidence of appendiceal CD was 0.55%. The chief complaints were right lower quadrant pain, abdominal pain, lower abdominal pain, and diarrhea. The duration of symptom varied from 2 d to 5 mo. The histologic review revealed appendiceal wall thickening in 11 cases (92%), transmural inflammation in all cases (100%), lymphoid aggregates in all cases (100%), epithelioid granulomas in all cases (100%), mucosal ulceration in 11 cases (92%), crypt abscesses in 5 cases (42%), perforation in 2 cases (17%), muscular hypertrophy in 1 case (8%), neural hyperplasia in 5 cases (42%), and perpendicular serosal fibrosis in 8 cases (67%). CONCLUSION: A typical and protracted clinical course, unusual gross features of the appendix and the characteristic histologic features are a clue in the diagnosis of appendiceal CD. PMID:25516865

  17. Students' Cognitive Processes While Learning from Teaching. Final Report: Appendices. (Volume Two).

    ERIC Educational Resources Information Center

    Winne, Philip H.; Marx, Ronald W.

    These appendices present the protocols used in research (reported in Volume 1) on the cognitive processes of students while learning from teaching. Curriculum outlines are given for the videotaped lessons used in the second and third studies: lessons in sleep and elementary psychology. Included in the appendices are: (1) the illustrative script…

  18. Strengthening Local K-12 Accountability: The Role of County Offices of Education. Technical Appendices

    ERIC Educational Resources Information Center

    Warren, Paul

    2016-01-01

    This document presents the technical appendices that accompany the full report, "Strengthening Local K-12 Accountability: The Role of County Offices of Education." The appendices include: (1) Data Collection Methods; and (2) PPIC Survey of California County Superintendents of Education. [For the full report, see ED570941.

  19. Determining College Readiness in California's Community Colleges: A Survey of Assessment and Placement Policies. Technical Appendices

    ERIC Educational Resources Information Center

    Rodriguez, Olga; Cuellar-Mejia, Marisol; Johnson, Hans

    2016-01-01

    This document presents the technical appendices that accompany the full report, "Determining College Readiness in California's Community Colleges: A Survey of Assessment and Placement Policies." The appendices include: (1) Survey Design and Administration; and (2) Survey Instrument. [This report was written with research support from…

  20. 46 CFR 197.580 - Appendices.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROVISIONS Benzene § 197.580 Appendices. (a) Appendices A through D and F of this subpart contain technical information on benzene and its effects and provide guidance for medical surveillance, monitoring,...

  1. 46 CFR 197.580 - Appendices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROVISIONS Benzene § 197.580 Appendices. (a) Appendices A through D and F of this subpart contain technical information on benzene and its effects and provide guidance for medical surveillance, monitoring,...

  2. 46 CFR 197.580 - Appendices.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROVISIONS Benzene § 197.580 Appendices. (a) Appendices A through D and F of this subpart contain technical information on benzene and its effects and provide guidance for medical surveillance, monitoring,...

  3. 46 CFR 197.580 - Appendices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROVISIONS Benzene § 197.580 Appendices. (a) Appendices A through D and F of this subpart contain technical information on benzene and its effects and provide guidance for medical surveillance, monitoring,...

  4. 46 CFR 197.580 - Appendices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROVISIONS Benzene § 197.580 Appendices. (a) Appendices A through D and F of this subpart contain technical information on benzene and its effects and provide guidance for medical surveillance, monitoring,...

  5. Information for Teachers (Including Classroom Activities), Skylab Student Project.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This program is intended to directly involve the educational community in space experiments, many of which can be related to existing curricula. Included in this first packet are: 1) a brief description of the Skylab Program and the National Science Teachers Association-National Aeronautics and Space Administration (NSTA-NASA) Skylab Student…

  6. Mars power system concept definition study. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Littman, Franklin D.

    1994-01-01

    This report documents the work performed by Rockwell International's Rocketdyne Division on NASA Contract No. NAS3-25808 (Task Order No. 16) entitled 'Mars Power System Definition Study'. This work was performed for NASA's Lewis Research Center (LeRC). The report is divided into two volumes as follows: Volume 1 - Study Results; and Volume 2 - Appendices. The results of the power system characterization studies, operations studies, and technology evaluations are summarized in Volume 1. The appendices include complete, standalone technology development plans for each candidate power system that was investigated.

  7. Mars power system concept definition study. Volume 2: Appendices

    NASA Astrophysics Data System (ADS)

    Littman, Franklin D.

    1994-12-01

    This report documents the work performed by Rockwell International's Rocketdyne Division on NASA Contract No. NAS3-25808 (Task Order No. 16) entitled 'Mars Power System Definition Study'. This work was performed for NASA's Lewis Research Center (LeRC). The report is divided into two volumes as follows: Volume 1 - Study Results; and Volume 2 - Appendices. The results of the power system characterization studies, operations studies, and technology evaluations are summarized in Volume 1. The appendices include complete, standalone technology development plans for each candidate power system that was investigated.

  8. Integration of New Technology in Army Libraries. Appendices.

    ERIC Educational Resources Information Center

    DAMANS and Associates, Rockville, MD.

    Eight appendices provide information related to a study which was conducted to determine the feasibility of introducing new automatic techniques to Army library technical processing activities; to examine and recommend appropriate systems and configurations for library automation; and to determine costs of implementing the recommendations. The…

  9. Funding California Schools: The Revenue Limit System. Technical Appendices

    ERIC Educational Resources Information Center

    Weston, Margaret

    2010-01-01

    This document presents the technical appendices accompanying the report, "Funding California Schools: The Revenue Limit System." Included are: (1) Revenue Limit Calculation and Decomposition; (2) Data and Methods; and (3) Base Funding Alternative Simulation Results. (Contains 5 tables and 26 footnotes.) [For the main report,…

  10. An Evaluation of Project Learning Tree in British Columbia. Appendices.

    ERIC Educational Resources Information Center

    Conry, Robert F.; And Others

    The volume contains seven appendices (A-G) which accompany the first volume. Appendix A provides a list of project personnel and of teachers who participated in the unit development workshop. Appendix B, composed of six sections, includes the unit lesson plans and teachers' guides used in the field study for grades 3, 5, and 7. The grade materials…

  11. Analysis and design of residential load centers. Volume 2: Appendices

    NASA Astrophysics Data System (ADS)

    Mehalick, E. M.; Lamders, R.; Obrien, G.; Tully, G. F.; Parker, J.

    1982-03-01

    These three appendices present information on residential load center classification information. Emphasis is given to: residential development trends and residential housing classifications; detached house site layout alternatives; and legal and institional issues, including condominium ownership, commercial ownership of photovoltaic systems in mobile homes, and utility ownership of photovoltaic systems.

  12. Business Plan : Supplemental Draft Environmental Impact Statement, Volume 2, Appendices.

    SciTech Connect

    United States. Bonneville Power Administration.

    1995-02-01

    This document contains the appendices for the Bonneville Power Administration (BPA) Business Plan: Supplemental Draft Environmental Impact Statement. Included are: BPA products and services; Rate design; Methodology and assumptions for numerical analysis; Retail utility operations; Comments and responses to the draft business plan EIS.

  13. Linkage between Graduate Medical Education Training Practice Profiles in Psychiatry, Obstetrics/Gynecology, and Family Practice. Appendices.

    ERIC Educational Resources Information Center

    SysteMetrics, Inc., Santa Barbara, CA.

    Provided are appendices for a study which examined the relationship between graduate medical education (GME) and practice profiles in three specialties: family practice, psychiatry, and obstetrics/gynecology. Appendix A includes materials related to methodology of the study. Appendices B-D include supplementary materials for family practice,…

  14. Appendices for EPAct/V2/E-89 Final Report on Program Design and Data Collection

    EPA Pesticide Factsheets

    This page contains the appendices A through P for EPAct/V2/E-89 Final Report on Program Design and Data Collection - First Report (PDF).Program design and data collection activities are described in the above report.

  15. United States Air Force 611th Air Support Group/Civil Engineering Squadron, Elmendorf AFB, Alaska. Remedial investigation and feasibility study: Oliktok Point Radar Installation, Alaska. Volume 1. (Includes appendices a - b)

    SciTech Connect

    1996-04-15

    This report presents the findings of Remedial Investigations and Feasibility Studies at sites located at the Oliktok Point radar installation in northern Alaska. The sites were characterized based on sampling and analyses conducted during Remedial Investigation activities performed during August and September 1993.

  16. Timeline analysis program (TLA-1), appendices

    NASA Technical Reports Server (NTRS)

    Miller, K. H.

    1976-01-01

    Appendices for the Timeline Analysis Program (TLA-1) were given. The appendices contain the Atlanta terminal area scenarios, the task catalog and the control and display configurations for the forward and aft flight decks of the NASA 515 aircraft, and the event/procedure, phase, mission, and subsystem catalogs.

  17. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.

    1981-01-01

    The current status of the Active Controls Technology (ACT) for the advanced subsonic transport project is investigated through analysis of the systems technical data. Control systems technologies under examination include computerized reliability analysis, pitch axis fly by wire actuator, flaperon actuation system design trade study, control law synthesis and analysis, flutter mode control and gust load alleviation analysis, and implementation of alternative ACT systems. Extensive analysis of the computer techniques involved in each system is included.

  18. Final safety analysis report for the Galileo Mission: Volume 2, Book 2: Accident model document: Appendices

    SciTech Connect

    Not Available

    1988-12-15

    This section of the Accident Model Document (AMD) presents the appendices which describe the various analyses that have been conducted for use in the Galileo Final Safety Analysis Report II, Volume II. Included in these appendices are the approaches, techniques, conditions and assumptions used in the development of the analytical models plus the detailed results of the analyses. Also included in these appendices are summaries of the accidents and their associated probabilities and environment models taken from the Shuttle Data Book (NSTS-08116), plus summaries of the several segments of the recent GPHS safety test program. The information presented in these appendices is used in Section 3.0 of the AMD to develop the Failure/Abort Sequence Trees (FASTs) and to determine the fuel releases (source terms) resulting from the potential Space Shuttle/IUS accidents throughout the missions.

  19. Appendiceal Enterobius vermicularis infestation in adults.

    PubMed

    Isik, Burak; Yilmaz, Mehmet; Karadag, Nese; Kahraman, Latif; Sogutlu, Gokhan; Yilmaz, Sezai; Kirimlioglu, Vedat

    2007-01-01

    The objective of this study is to evaluate the incidence of Enterobius vermicularis in the appendices of the adult population and a possible relationship between E. vermicularis and acute appendicitis. E. vermicularis was identified in 18 (2%) of 890 patients. Six hundred sixty-five operations were performed for presumptive diagnosis of acute appendicitis, and E. vermicularis was found in 12 (2%) patients. The histopathological examination revealed acute inflammatory cells in four cases (33%). Three of these four specimens included luminal ova and one E. vermicularis. Histopathological examination of six cases revealed E. vermicularis in 225 incidental appendectomies with no evidence of either acute or chronic inflammatory cells. This study suggests a relationship between the presence of E. vermicularis ova and acute inflammation, but the presence of the pinworm in the lumen of the appendix is coincidental. On the other hand E. vermicularis in the appendix lumen can cause symptoms of acute appendicitis.

  20. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project. ACT/Control/Guidance System study. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The integrated application of active controls (IAAC) technology to an advanced subsonic transport is reported. Supplementary technical data on the following topics are included: (1) 1990's avionics technology assessment; (2) function criticality assessment; (3) flight deck system for total control and functional features list; (4) criticality and reliability assessment of units; (5) crew procedural function task analysis; and (6) recommendations for simulation mechanization.

  1. ARPA Market Study. Appendices

    DTIC Science & Technology

    1994-05-10

    selected In Step 1. i 3. An application or user edits the view Instances for a (possibly) extended period of Utme. 4. The new values of the view Instances...Format blocks and converting them into any final standard that develops. In this way, IC manufacturers who start delivering to the format today are...recommendations for new standards. These steps are incorporated into this document and form the basis of the roadmap (PERT chart) included in section

  2. 1992-1993 Bonneville Appliance Efficiency Program: Showerhead Evaluation Volume II - Appendices

    SciTech Connect

    Warwick, W.M.

    1995-01-01

    This report included the appendices for 1992-1993 Bonneville appliance efficiency program: showerhead evaluation. It consists of nine appendices, titled: Bonneville documents; overview of research projects; Puget Power and Light persistence study; hot-water flow analyses and assumptions documentation; regional end-use metering program; showerhead and faucet aerator performance assessment; Bonneville showerhead program distribution methods by participating utility; water- and energy-saving measure distribution methods literature review; REMP study load shape results.

  3. Alternative fuels for vehicles fleet demonstration program. Final report, volume 2: Appendices

    SciTech Connect

    1997-06-01

    The Alternative Fuels for Vehicles Fleet Demonstration Program (AFV-FDP) was a multiyear effort to collect technical data for use in determining the costs and benefits of alternative-fuel vehicles (AFVs) in typical applications in New York State. This report, Volume 2, includes 13 appendices to Volume 1 that expand upon issues raised therein. Volume 1 provides: (1) Information about the purpose and scope of the AFV-FDP; (2) A summary of AFV-FDP findings organized on the basis of vehicle type and fuel type; (3) A short review of the status of AFV technology development, including examples of companies in the State that are active in developing AFVs and AFV components; and (4) A brief overview of the status of AFV deployment in the State. Volume 3 provides expanded reporting of AFV-FDP technical details, including the complete texts of the brochure Garage Guidelines for Alternative Fuels and the technical report Fleet Experience Survey Report, plus an extensive glossary of AFV terminology. The appendices cover a wide range of issues including: emissions regulations in New York State; production and health effects of ozone; vehicle emissions and control systems; emissions from heavy-duty engines; reformulated gasoline; greenhouse gases; production and characteristics of alternative fuels; the Energy Policy Act of 1992; the Clean Fuel Fleet Program; garage design guidelines for alternative fuels; surveys of fleet managers using alternative fuels; taxes on conventional and alternative fuels; and zero-emission vehicle technology.

  4. Numerical aerodynamic simulation facility preliminary study, volume 2 and appendices

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Data to support results obtained in technology assessment studies are presented. Objectives, starting points, and future study tasks are outlined. Key design issues discussed in appendices include: data allocation, transposition network design, fault tolerance and trustworthiness, logic design, processing element of existing components, number of processors, the host system, alternate data base memory designs, number representation, fast div 521 instruction, architectures, and lockstep array versus synchronizable array machine comparison.

  5. Orbiting propellant depot safety. Volume 3: Appendices

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Appendices to support the findings of the Orbiting Propellant Depot Safety study are presented. The subjects discussed are ullage control subsystems, evaluation of methods, propellant transfer, and baseline subsystem selection.

  6. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Credit for market promotion activities, including paid... promotion activities, including paid advertising. (a) In order for a handler to receive credit for his/her...) Other market promotion activities. Credit-Back shall be granted for market promotion other than...

  7. Geothermal resource assessment for the state of Texas: status of progress, November 1980. Final report. Appendices A through D

    SciTech Connect

    Woodruff, C.M. Jr.; Caran, S.C.; Gever, C.; Henry, C.D.; Macpherson, G.L.; McBride, M.W.

    1982-03-01

    These appendices include: a folio of county maps showing locations of well data across the state; a computerized tabulation of the wells depicted; an explanation of the computer coding procedures; and a selected bibliography on heat flow and geothermics. (MHR)

  8. Appendiceal mucocoele with midgut malrotation

    PubMed Central

    Hassall, J; Williams, GL; McKain, ES

    2016-01-01

    Introduction Malrotation of the midgut and appendiceal mucocoele are both extremely rare pathological conditions in adults. To our knowledge, there are only two reported cases in the English literature with a combination of both conditions. Case History A 65-year-old man presented with a 10-day history of upper abdominal pain associated with abdominal bloating and weight loss. He was otherwise fit and healthy with no significant past medical history. On examination, his abdomen was soft with tenderness and palpable fullness over the left upper quadrant. The initial blood test, chest x-ray and abdominal x-ray demonstrated no significant abnormality. Computed tomography showed a 17cm x 8cm x 6cm elongated cystic mass with possible malrotation of the intestines. Histopathology showed a low grade mucinous tumour of the appendix. At 12 months following surgery, there was no evidence of recurrence or postoperative complications and the patient was discharged from the care of the colorectal team. Conclusions We report a patient with a combination of two rare conditions. This case illustrates how a combination of pathologies can present a challenge to the unwary general surgeon. PMID:27269433

  9. Nuclear actin activates human transcription factor genes including the OCT4 gene.

    PubMed

    Yamazaki, Shota; Yamamoto, Koji; Tokunaga, Makio; Sakata-Sogawa, Kumiko; Harata, Masahiko

    2015-01-01

    RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.

  10. High School Choice in New York City: A Report on the School Choices and Placements of Low-Achieving Students. Technical Appendices

    ERIC Educational Resources Information Center

    Nathanson, Lori; Corcoran, Sean; Baker-Smith, Christine

    2013-01-01

    This document presents the technical appendices that accompany the full report, "High School Choice in New York City: A Report on the School Choices and Placements of Low-Achieving Students." The appendices include: (1) The Shrinking Pool of Level 1 and Level 2 Students; and (2) Supplemental Tables and Figures. [For the full report, see…

  11. "Who Stays and Who Leaves?" Findings from a Three-Part Study of Teacher Turnover in NYC Middle Schools. Technical Appendices

    ERIC Educational Resources Information Center

    Marinell, William H.; Coca, Vanessa M.; Arum, Richard; Goldstein, Jennifer; Kemple, James; Pallas, Aaron; Bristol, Travis; Buckley, Clare; Scallon, Amy; Tanner, Barbara

    2013-01-01

    The technical appendices presented in this document correspond to the synthesis report, "'Who Stays and Who Leaves?' Findings from a Three-Part Study of Teacher Turnover in NYC Middle Schools." The appendices include: (1) Description of Data Source and Samples; (2) Methods; and (3) Who Are the Middle School Teachers in NYC? [The…

  12. 29 CFR Appendices to Subpart L of... - Note

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Note Appendices to Subpart L of Part 1910 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Pt. 1910, Subpt. L, Apps. Nt. Appendices to Subpart L of Part 1910—Note Note: The following appendices to subpart L, except appendix E, serve...

  13. 29 CFR Appendices to Subpart L of... - Note

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Note Appendices to Subpart L of Part 1910 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Pt. 1910, Subpt. L, Apps. Nt. Appendices to Subpart L of Part 1910—Note Note: The following appendices to subpart L, except appendix E, serve...

  14. 29 CFR Appendices to Subpart L of... - Note

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Note Appendices to Subpart L of Part 1910 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Pt. 1910, Subpt. L, Apps. Nt. Appendices to Subpart L of Part 1910—Note Note: The following appendices to subpart L, except appendix E, serve...

  15. 29 CFR Appendices to Subpart L of... - Note

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Note Appendices to Subpart L of Part 1910 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Pt. 1910, Subpt. L, Apps. Nt. Appendices to Subpart L of Part 1910—Note Note: The following appendices to subpart L, except appendix E, serve...

  16. 29 CFR Appendices to Subpart L of... - Note

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Note Appendices to Subpart L of Part 1910 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Pt. 1910, Subpt. L, Apps. Nt. Appendices to Subpart L of Part 1910—Note Note: The following appendices to subpart L, except appendix E, serve...

  17. 45 CFR 2102.14 - Consent Calendar and Appendices procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Consent Calendar and Appendices procedures. 2102... § 2102.14 Consent Calendar and Appendices procedures. (a) The Commission shall review applications scheduled on its Meeting Agenda, Consent Calendar, or Appendices (Old Georgetown Act and Shipstead-Luce...

  18. 45 CFR 2102.14 - Consent Calendar and Appendices procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Consent Calendar and Appendices procedures. 2102... § 2102.14 Consent Calendar and Appendices procedures. (a) The Commission shall review applications scheduled on its Meeting Agenda, Consent Calendar, or Appendices (Old Georgetown Act and Shipstead-Luce...

  19. 45 CFR 2102.14 - Consent Calendar and Appendices procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Consent Calendar and Appendices procedures. 2102... § 2102.14 Consent Calendar and Appendices procedures. (a) The Commission shall review applications scheduled on its Meeting Agenda, Consent Calendar, or Appendices (Old Georgetown Act and Shipstead-Luce...

  20. 45 CFR 2102.14 - Consent Calendar and Appendices procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Consent Calendar and Appendices procedures. 2102... § 2102.14 Consent Calendar and Appendices procedures. (a) The Commission shall review applications scheduled on its Meeting Agenda, Consent Calendar, or Appendices (Old Georgetown Act and Shipstead-Luce...

  1. 45 CFR 2102.14 - Consent Calendar and Appendices procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Consent Calendar and Appendices procedures. 2102... § 2102.14 Consent Calendar and Appendices procedures. (a) The Commission shall review applications scheduled on its Meeting Agenda, Consent Calendar, or Appendices (Old Georgetown Act and Shipstead-Luce...

  2. Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 2, Appendices A--L.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-01-01

    This report consists of appendices A-L of the final environmental impact statement for the Bonneville Power Administration. The appendices provide information on the following: Ninth circuit Court opinion in Forelaws on Board v. Johnson; guide to Northwest Power act contracts; guide to hydro operations; glossary; affected environment supporting documentation; environmental impacts of generic resource types; information on models used; technical information on analysis; public involvement activities; bibliography; Pacific Northwest Electric Power Planning and Conservation Act; and biological assessment. (CBS)

  3. Lower Susquehanna River hydrographic and water quality study, Summer 1981. Volume 2: appendices. Final report

    SciTech Connect

    Potera, G.T.; Philipp, K.R.; Johnson, T.D.; Petrimoulx, H.J.; Klose, P.N.

    1982-03-17

    This report includes appendices to Volume 1, which presents field data on temperature and dissolved oxygen of the Conowingo Dam and the Conowingo Reservoir for use as input to modeling simulations of the Susquehanna River. The modeling simulations were designed to meet requirements of the operating license for Conowingo Dam issued by the Federal Energy Regulatory Commission. Appendices included are: (1) instrument specifications; (2) dye study: time of travel results; (3) dye study: nearfield study results - discrete releases; (4) dye study: nearfield study results - daily summaries; and (5) reaeration data.

  4. Diagnosis and Treatment of Mucinous Appendiceal Neoplasm Presented as Acute Appendicitis

    PubMed Central

    Kehagias, Ioannis; Markopoulos, Georgios; Papandreou, Thanasis; Kraniotis, Pantelis

    2016-01-01

    Appendiceal mucocele is a rare cause of acute abdomen. Mucinous appendiceal neoplasms represent 0.2–0.7% of all appendix specimens. The aim of this study is to report a case of a mucinous appendiceal neoplasm presented as acute appendicitis, discussing the clinical and surgical approach in the emergency setting. A 72-year-old female patient was admitted to the emergency department with a clinical examination indicative of acute abdomen. The patient underwent abdominal computed tomography scan which revealed a cystic lesion in the right iliac fossa measuring 8.3 × 5.2 × 4.1 cm, with calcified walls, and a mean density indicative of high protein content. The patient was taken to the operating room and a right hemicolectomy was performed. The postoperative course was unremarkable. The histopathological examination revealed a low-grade mucinous appendiceal neoplasm with negative regional lymph nodes. Ultrasound and CT are useful in diagnosing appendiceal mucocele and synchronous cancers in the emergency setting. The initial operation should include appendectomy and resection of the appendicular mesenteric fat along with any fluid collection for cytologic examination. During urgent appendectomy it is important to consider every mucocele as malignant in order to avoid iatrogenic perforation causing pseudomyxoma peritonei. Although laparotomy is recommended, the laparoscopic approach is not contraindicated. PMID:27066284

  5. The appropriate management of an appendiceal mucocele

    PubMed Central

    Lorenzon, Laura; De Dominicis, Chiara; Virgilio, Edoardo; Balducci, Genoveffa

    2015-01-01

    Appendicectomy is one of the most commonly performed surgical procedures. Appendiceal mucocele is a relative rare disease, but appropriate management is critical. Indeed, the intact removal of a mucocele represents a curative treatment; conversely, a rupture may result in the spread of epithelial cells throughout the peritoneal cavity (pseudomyxoma peritonei). We report a case of a 61-year-old woman, admitted to our department, who underwent resection of an appendiceal mucocele, focusing, in the discussion, on the clinical and surgical management of this disease. PMID:25777488

  6. Improvements to the FATOLA computer program including added actively controlled landing gear subroutines

    NASA Technical Reports Server (NTRS)

    Mall, G. H.

    1983-01-01

    Modifications to a multi-degree-of-freedom flexible aircraft take-off and landing analysis (FATOLA) computer program, including a provision for actively controlled landing gears to expand the programs simulation capabilities, are presented. Supplemental instructions for preparation of data and for use of the modified program are included.

  7. Liquid rocket booster integration study. Volume 5, part 1: Appendices

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The impacts of introducing liquid rocket booster engines (LRB) into the Space Transportation System (STS)/Kennedy Space Center (KSC) launch environment are identified and evaluated. Proposed ground systems configurations are presented along with a launch site requirements summary. Prelaunch processing scenarios are described and the required facility modifications and new facility requirements are analyzed. Flight vehicle design recommendations to enhance launch processing are discussed. Processing approaches to integrate LRB with existing STS launch operations are evaluated. The key features and significance of launch site transition to a new STS configuration in parallel with ongoing launch activities are enumerated. This volume is the appendices of the five volume series.

  8. In-Suit Light Exercise (ISLE) Prebreathe Protocol Peer Review Assessment. Part 2; Appendices

    NASA Technical Reports Server (NTRS)

    Brady, Timothy K.; Polk, James D.

    2011-01-01

    The performance of extravehicular activity (EVA) by National Aeronautics and Space Administration astronauts involves the risk of decompression sickness. This risk has been mitigated by the use of oxygen "prebreathe" to effectively wash out tissue nitrogen prior to each EVA. Now that the Space Shuttle Program (SSP) is being retired, high-pressure oxygen will become a limited resource. The In-Suit Light Exercise (ISLE) Prebreathe Protocol offers several potential benefits including its potential to save 6 pounds of oxygen per EVA. At the request of the NASA Engineering and Safety Center, the peer review convened on October 14, 2010. The major recommendation of the Review Committee was that the ISLE protocol was acceptable for operational use as a prebreathe option prior to EVA. The appendices to Volume I of the report are contained in this document.

  9. Evaluation of School-Based Right to Read Sites; Volume IV, Appendices.

    ERIC Educational Resources Information Center

    Contemporary Research, Inc., Los Angeles, CA.

    This collection of appendices to the "Evaluation of School-Based Right to Read Sites" includes "Evaluation of Right to Read Materials," which presents an overview and discusses the evaluation procedure and evaluation results; "Instruments," which includes mail-out materials and regional conference materials;…

  10. Worldwide status of energy standards for buildings: Appendices

    SciTech Connect

    Janda, K.B.; Busch, J.F.

    1993-02-01

    This informal survey was designed to gain information about the worldwide status of energy efficiency standards for buildings, particularly non-residential buildings such as offices, schools, and hotels. The project has three goals: 1. To understand and learn from the experience of countries with existing building energy standards; 2. To locate areas where these lessons might be applied and energy standards might be effectively proposed and developed; and 3. To share the information gathered with all participating countries. These appendices include the survey cover letter, the survey, and the details of selected energy standards in 35 countries, thus providing supporting material for the authors` article of the same title.

  11. Surgical management of appendiceal adenocarcinoid. Case report and literature review.

    PubMed

    González-Sánchez-Migallón, Elena; Valero-Navarro, Graciela; Sola-Pérez, Joaquín; García-Marín, José Andrés; Verdú-Fernández, María Ángeles; Soria-Aledo, Victoriano; Aguayo-Albasini, José Luis

    2016-03-01

    Adenocarcinoid tumour of the appendix is a rare entity characterised by the presence of a double component (neuroendocrine and glandular). It originates in the neuroendocrine cells of the appendicular mucosa. A preoperative diagnosis of a primary appendiceal tumour is uncommon and more so one suggesting an adenocarcinoid pathology. Optimal treatment is debated between a simple appendectomy and a more extensive resection, which occasionally includes hysterectomy and bilateral ovariectomy. Our aim is to report this rare entity and conduct a review of the literature on the different treatment options.

  12. Site Safety and Health Plan (SSHP) for a Transportable Incineration System (TIS) at the Savanna Army Depot Activity (SADA), Washout Lagoon Area. Appendices

    DTIC Science & Technology

    1991-03-08

    PCB- containing fluids including dioxins and dibenzofurans for the Electric Power Research Institute; literature review update on Agent Orange for the...systems manager for development and operation of Rocky Mountain Arsenal, Dugway Proving -- Ground, and Tooele Army Depot Chemical Agent Munitions...solvent enriched with considerable explosive * as fuel for a turbine-powered electrical generator, and chemical conversion of incapacitating agent CS

  13. Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm.

    PubMed

    Vyas, Monika; Wong, Serena; Zhang, Xuchen

    2017-01-01

    Endometriosis of the appendix can be an incidental finding or a cause of appendicitis, intussusception, perforation or retention mucocele. Intestinal metaplasia of appendiceal endometriosis may occur, which can lead to a misdiagnosis of low-grade appendiceal mucinous neoplasm. On a retrospective search of the pathology database from 2001 to 2015, we identified 78 appendiceal endometriosis cases and intestinal metaplasia was present in 10/78 (13%) cases. In most of the cases (90%), the foci of intestinal metaplasia were mainly localized close to the mucosa. Intestinal and endometrial hybrid glands were present in 9/10 (90%) cases. These cases were often associated with marked appendiceal distortion, luminal obliteration and mass formation, causing concern for a mucinous neoplasm clinically and pathologically. Our findings indicate that intestinal metaplasia in appendiceal endometriosis is not an uncommon phenomenon, which can be mistaken for a mucinous neoplasm. Endometriosis should be kept in mind when a diagnosis of appendiceal mucinous neoplasm is made, especially in a young woman with a clinical history of endometriosis.

  14. Public-Private Ventures for Morale, Welfare, and Recreation Activities. A Solution to the Loss of Appropriated Funds. Volume 6. Appendices M and N

    DTIC Science & Technology

    1990-07-01

    Report NA705R1 DTIC S ~FECTE D AUG 31 1990i S July 1990 Trevor L . Neve Jordan W. Cassell Robert L . Crosslin Robert A. Hutchinson Appzvs * :z: - el...DOCUMENTATION PAGE Fan" oAod ,W Jlomet, omAU, Ve.,v,,O g eh. owi g v 6 . m ,,him,. ei _ e i au. ea Ia w O a qkyi .W l ,,, iqeem. V,,JJe dMv . set U l i e Off...TI.Tfu ANo S TITLE Public-Private Ventures for Morale, L U NUMURS Welfare, and Recreation Activities: A Solution to the Loss of Appropriated Funds

  15. Spacecraft software training needs assessment research, appendices

    NASA Technical Reports Server (NTRS)

    Ratcliff, Shirley; Golas, Katharine

    1990-01-01

    The appendices to the previously reported study are presented: statistical data from task rating worksheets; SSD references; survey forms; fourth generation language, a powerful, long-term solution to maintenance cost; task list; methodology; SwRI's instructional systems development model; relevant research; and references.

  16. Solar attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Astrophysics Data System (ADS)

    Azor, Ruth

    1992-08-01

    In geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances, caused mainly by solar pressure. This work presents a roll/yaw control, which is obtained by the use of solar arrays and fixed flaps as actuators, with a horizon sensor for roll measurement. The design also includes an active nutation damping.

  17. Solar sail attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Technical Reports Server (NTRS)

    Azor, Ruth

    1992-01-01

    In geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances, caused mainly by solar radiation pressure. This work presents a roll/yaw control which is obtained by the use of solar arrays and fixed flaps as actuators, with a horizon sensor for roll measurement. The design also includes an active nutation damping.

  18. Implementation of the Project "Including Disabled Senior Citizens in Creative Activities in 2013-2015"

    ERIC Educational Resources Information Center

    Ploch, Leszek

    2015-01-01

    This paper made an attempt to indicate the findings of the author's research from the experiences of the implementation of the project "Including disabled senior citizens in creative activities in 2013-2015". The issues of disabled senior citizens have been an object of interest over the recent years though it still has not had a proper…

  19. Modifying Physical Activities to Include Individuals with Disabilities: A Systematic Approach

    ERIC Educational Resources Information Center

    Menear, Kristi S.; Davis, Tim

    2007-01-01

    Effectively including individuals with disabilities in a physical activity setting can often be a challenge due to constraints related to equipment, class size, curriculum, and the various ability levels of individuals with and without disabilities. However, there are ways the instructor can control the environment and tasks to meet the needs of…

  20. An Initial Evaluation of the North Carolina Alcohol and Drug Education Traffic Schools. Volume II: Appendices.

    ERIC Educational Resources Information Center

    Popkin, Carol L.; And Others

    This volume is the second part of a report evaluating the North Carolina Alcohol Drug Education Traffic Schools (ADETS), established for the primary purpose of treating first offenders convicted of driving under the influence (DUI). These appendices include copies of legislation pertaining to the schools; a copy of the DMH 2604 referral form; an…

  1. An Evaluation of Non-Formal Education in Ecuador. Volume 4: Appendices. Final Report.

    ERIC Educational Resources Information Center

    Laosa, Luis M.; And Others

    As the final volume in a 4-volume evaluation report on the University of Massachusetts Non-Formal Education Project (UMass NFEP) initiated in rural Ecuador in 1973, this volume presents appendices to volumes I-III. Appendix A includes the following items: (1) Community Demographic Profile; (2) Description of Introduction to the Community; (3)…

  2. Measurement of Lake Roosevelt Biota in Relation to Reservoir Operations : Appendices 1992.

    SciTech Connect

    Griffith, Janelle R.; McDowell, Amy C.

    1996-01-01

    These appendices include: A RESERVOIR ELEVATION AND WATER RETENTION TIME: Daily reservoir levels and water retention time in 1992, Elevation vs area, Elevation vs gross storage; B ZOOPLANKTON: Zooplankton density, Zooplanktion biomass; C BENTHIC MACROINVERTEBRATE DATA: Benthic sampling record, Benthic sampling depths, Benthic orders identified, Mean weight values obtained for benthics, D WATER COLUMN PROFILE: Monthly water profiles.

  3. Production development of organic nonflammable spacecraft potting, encapsulating and conformal coating compounds. Volume 3: Appendices

    NASA Technical Reports Server (NTRS)

    Lieberman, S. L.

    1974-01-01

    Appendices are presented which include: statement of work; material vendor contacts; formulation/processing data sheet; upward propagation test; flammability test conditions/results sheet; odor test; vacuum stability requirements; flammability test facility; determination of offgassing products and carbon monoxide test; and pneumatic and mechanical impact test guidelines.

  4. Solar sail attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Astrophysics Data System (ADS)

    Azor, Ruth

    1992-02-01

    In the geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances caused by solar radiation pressure. This work presents a roll/yaw control system with a horizon sensor for roll measurement. Roll/yaw control is obtained by the use of solar arrays and fixed flaps as actuators. The design also includes an active nutation damping method.

  5. Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.

    PubMed

    Corton, J Christopher; Apte, Udayan; Anderson, Steven P; Limaye, Pallavi; Yoon, Lawrence; Latendresse, John; Dunn, Corrie; Everitt, Jeffrey I; Voss, Kenneth A; Swanson, Cynthia; Kimbrough, Carie; Wong, Jean S; Gill, Sarjeet S; Chandraratna, Roshantha A S; Kwak, Mi-Kyoung; Kensler, Thomas W; Stulnig, Thomas M; Steffensen, Knut R; Gustafsson, Jan-Ake; Mehendale, Harihara M

    2004-10-29

    The obesity epidemic in industrialized countries is associated with increases in cardiovascular disease (CVD) and certain types of cancer. In animal models, caloric restriction (CR) suppresses these diseases as well as chemical-induced tissue damage. These beneficial effects of CR overlap with those altered by agonists of nuclear receptors (NR) under control of the fasting-responsive transcriptional co-activator, peroxisome proliferator-activated co-activator 1alpha (PGC-1alpha). In a screen for compounds that mimic CR effects in the liver, we found statistically significant overlaps between the CR transcript profile in wild-type mice and the profiles altered by agonists of lipid-activated NR, including peroxisome proliferator-activated receptor alpha (PPARalpha), liver X receptor, and their obligate heterodimer partner, retinoid X receptor. The overlapping genes included those involved in CVD (lipid metabolism and inflammation) and cancer (cell fate). Based on this overlap, we hypothesized that some effects of CR are mediated by PPARalpha. As determined by transcript profiling, 19% of all gene expression changes in wild-type mice were dependent on PPARalpha, including Cyp4a10 and Cyp4a14, involved in fatty acid omega-oxidation, acute phase response genes, and epidermal growth factor receptor but not increases in PGC-1alpha. CR protected the livers of wild-type mice from damage induced by thioacetamide, a liver toxicant and hepatocarcinogen. CR protection was lost in PPARalpha-null mice due to inadequate tissue repair. These results demonstrate that PPARalpha mediates some of the effects of CR and indicate that a pharmacological approach to mimicking many of the beneficial effects of CR may be possible.

  6. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review.

    PubMed

    Ricketts, Marie-Louise; Moore, David D; Banz, William J; Mezei, Orsolya; Shay, Neil F

    2005-06-01

    Consumption of soy has been demonstrated to reduce circulating cholesterol levels, most notably reducing low-density lipoprotein (LDL) cholesterol levels in hypercholesterolemic individuals. The component or components that might be responsible for this effect is still a matter of debate or controversy among many researchers. Candidate agents include an activity of soy protein itself, bioactive peptides produced during the digestive process, or the soy isoflavones. Although soy intake may provide other health benefits including preventative or remediative effects on cancer, osteoporosis and symptoms of menopause, this review will focus on isoflavones as agents affecting lipid metabolism. Isoflavones were first discovered as a bioactive agent disrupting estrogen action in female sheep, thereby earning the often-used term 'phytoestrogens'. Subsequent work confirmed the ability of isoflavones to bind to estrogen receptors. Along with the cholesterol-lowering effect of soy intake, research that is more recent has pointed to a beneficial antidiabetic effect of soy intake, perhaps mediated by soy isoflavones. The two common categories of antidiabetic drugs acting on nuclear receptors known as peroxisome proliferator activated receptors (PPARs) are the fibrates and glitazones. We and others have recently asked the research question 'do the soy isoflavones have activities as either "phytofibrates" or "phytoglitazones"?' Such an activity should be able to be confirmed both in vivo and in vitro. In both the in vivo and in vitro cases, this action has indeed been confirmed. Further work suggests a possible action of isoflavones similar to the nonestrogenic ligands that bind the estrogen-related receptors (ERRs). Recently, these receptors have been demonstrated to contribute to lipolytic processes. Finally, evaluation of receptor activation studies suggests that thyroid receptor activation may provide additional clues explaining the metabolic action of isoflavones. The recent

  7. [Appendiceal neuroendocrine tumor with lymph node metastasis in a teenager].

    PubMed

    Kim, Keun Young; Park, Won Cheol

    2015-02-01

    Neuroendocrine tumor (NET) is a cancer-like tumor that occurs mostly in the gastrointestinal system. Within the gastrointestinal tract, NET most commonly occurs in the rectum whereas appendix is very rarely involved. In most cases of appendiceal NET, it is found at a relatively early stage compared to other NETs because appendiceal NET frequently presents with acute appendicitis because appendiceal NET frequently presents with acute appendicitis even when the size is smaller than 1 cm. Therefore, it is very rare for lymph node metastasis to occur in a young adult. Herein, we report a rare case of grade 1 appendiceal NET with lymph node metastasis which developed in a teenage male.

  8. A computer program (HEVSIM) for heavy duty vehicle fuel economy and performance simulation. Volume III: Appendices A through F. Final report Mar-Oct 80

    SciTech Connect

    Buck, R.E.

    1981-09-01

    Volume III is the third and last volume of a three volume document describing the computer program HEVSIM. This volume includes appendices which list the HEVSIM program, sample part data, some typical outputs and updated nomenclature.

  9. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.

    PubMed

    Koo, Taeyoung; Lee, Jungjoon; Kim, Jin-Soo

    2015-06-01

    Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations.

  10. Is there still a benefit to operate appendiceal abscess on board French nuclear submarines?

    PubMed

    Hornez, Emmanuel; Gellie, Gabriel; Entine, Fabrice; Ottomani, Sébastien; Monchal, Tristan; Meusnier, François; Platel, Jean Philippe; de Carbonnieres, Hubert; Thouard, Hervé

    2009-08-01

    Appendicular abscess occurred in 14.2% of patients presenting acute appendicitis. Management of these patients remains controversial, ranging from an emergency appendectomy to a nonoperative treatment. On board French nuclear submarines, the usual treatment for all cases of appendiceal masses, including both appendicitis and appendiceal abscess, is an appendectomy. In the past 5 years, the introduction of ultrasonography (US) on board has enabled the diagnosis of appendiceal abscess with a high rate of accuracy, and the latest studies show that nonoperative treatment is an alternative approach. This nonsurgical treatment, based on intravenous administration of antibiotics, is successful in about 93% of the patients. Failure of nonsurgical treatment is a reliable indication of percutaneous drainage. The proportion of adult patients who need percutaneous drainage of abscesses is about 27%. A successful primary nonoperative treatment may or may not be followed by interval appendectomy at the conclusion of the patrol. Nonsurgical treatment is associated with a significantly lower morbidity than surgery. Considering that the on-board surgical facility is limited, nonsurgical treatment appears to be the best approach for treating a sailor with an appendiceal abscess during a submarine patrol mission.

  11. Tiger Team Assessment of the Savannah River Site: Appendices

    SciTech Connect

    Not Available

    1990-06-01

    This draft document contains findings identified during the Tiger Team Compliance Assessment of the US Department of Energy Savannah River Site (SRS), located in three countries (Aiken, Barnwell and Allendale), South Carolina. The Assessment was directed by the Department's Office of the Assistant Secretary for Environment, Safety, and Health (ES H) and was conducted from January 29 to March 23, 1990. The Savannah River Site Tiger Team Compliance Assessment was broad in scope covering the Environment, Safety and Health, and Management areas and was designed to determine the site's compliance with applicable Federal (including DOE), state, and local regulations and requirements. The scope of the Environmental assessment was sitewide while the Safety and Health assessments included site operating facilities (except reactors), and the sitewide elements of Aviation Safety, Emergency Preparedness, Medical Services, and Packaging and Transportation. This report contains the appendices to the assessment.

  12. Should singing activities be included in speech and voice therapy for prepubertal children?

    PubMed

    Rinta, Tiija; Welch, Graham F

    2008-01-01

    Customarily, speaking and singing have tended to be regarded as two completely separate sets of behaviors in clinical and educational settings. The treatment of speech and voice disorders has focused on the client's speaking ability, as this is perceived to be the main vocal behavior of concern. However, according to a broader voice-science perspective, given that the same vocal structure is used for speaking and singing, it may be possible to include singing in speech and voice therapy. In this article, a theoretical framework is proposed that indicates possible benefits from the inclusion of singing in such therapeutic settings. Based on a literature review, it is demonstrated theoretically why singing activities can potentially be exploited in the treatment of prepubertal children suffering from speech and voice disorders. Based on this theoretical framework, implications for further empirical research and practice are suggested.

  13. Space industrialization. Volume 4: Appendices

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Program development and analysis and recommendations for NASA activities are discussed. The impact of international space law on future use of outer space is examined in the light of applicable international agreements. Recommendations for actions designed to facilitate space industralization are also proposed.

  14. 24 CFR Appendices A-C to Subtitle A - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false A Appendices A-C to Subtitle A Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development Appendices A-C to Subtitle A...

  15. 24 CFR Appendices A-C to Subtitle A - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false A Appendices A-C to Subtitle A Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development Appendices A-C to Subtitle A...

  16. 24 CFR Appendices A-C to Subtitle A - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false A Appendices A-C to Subtitle A Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development Appendices A-C to Subtitle A...

  17. 24 CFR Appendices A-C to Subtitle A - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false A Appendices A-C to Subtitle A Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development Appendices A-C to Subtitle A...

  18. Market analysis of shale oil co-products. Appendices

    SciTech Connect

    Not Available

    1980-12-01

    Data are presented in these appendices on the marketing and economic potential for soda ash, aluminia, and nahcolite as by-products of shale oil production. Appendices 1 and 2 contain data on the estimated capital and operating cost of an oil shales/mineral co-products recovery facility. Appendix 3 contains the marketing research data.

  19. 34 CFR Appendices A-B to Part 682 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 4 2011-07-01 2011-07-01 false A Appendices A-B to Part 682 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Appendices A-B to Part 682...

  20. 34 CFR Appendices A-B to Part 682 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 4 2013-07-01 2013-07-01 false A Appendices A-B to Part 682 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Appendices A-B to Part 682...

  1. 34 CFR Appendices A-B to Part 682 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 4 2012-07-01 2012-07-01 false A Appendices A-B to Part 682 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Appendices A-B to Part 682...

  2. 34 CFR Appendices A-C to Part 682 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 4 2014-07-01 2014-07-01 false A Appendices A-C to Part 682 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Appendices A-C to Part 682...

  3. 7 CFR 6.34 - Adjustment of Appendices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Adjustment of Appendices. 6.34 Section 6.34 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.34 Adjustment of Appendices. (a) Whenever a historical license (Appendix 1) is not issued...

  4. 14 CFR Appendices I-J to Part 121 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false I Appendices I-J to Part 121 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND... SUPPLEMENTAL OPERATIONS Appendices I-J to Part 121...

  5. 14 CFR Appendices I-J to Part 121 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false I Appendices I-J to Part 121 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND... SUPPLEMENTAL OPERATIONS Appendices I-J to Part 121...

  6. 14 CFR Appendices I-J to Part 121 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false I Appendices I-J to Part 121 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND... SUPPLEMENTAL OPERATIONS Appendices I-J to Part 121...

  7. 12 CFR Appendices F-G to Part 222 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false F Appendices F-G to Part 222 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Appendices F-G to Part 222...

  8. 12 CFR Appendices F-I to Part 717 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false F Appendices F-I to Part 717 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS FAIR CREDIT REPORTING Appendices F-I to Part 717...

  9. 12 CFR Appendices F-I to Part 717 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false F Appendices F-I to Part 717 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS FAIR CREDIT REPORTING Appendices F-I to Part 717...

  10. 12 CFR Appendices F-I to Part 334 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false F Appendices F-I to Part 334 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY FAIR CREDIT REPORTING Appendices F-I to Part 334...

  11. 12 CFR Appendices F-I to Part 571 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false F Appendices F-I to Part 571 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FAIR CREDIT REPORTING Appendices F-I to Part 571...

  12. 12 CFR Appendices F-I to Part 571 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false F Appendices F-I to Part 571 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FAIR CREDIT REPORTING Appendices F-I to Part 571...

  13. 12 CFR Appendices F-I to Part 41 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false F Appendices F-I to Part 41 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR CREDIT REPORTING Appendices F-I to Part 41...

  14. 12 CFR Appendices F-I to Part 334 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false F Appendices F-I to Part 334 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY FAIR CREDIT REPORTING Appendices F-I to Part 334...

  15. 12 CFR Appendices F-I to Part 222 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false F Appendices F-I to Part 222 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM FAIR CREDIT REPORTING (REGULATION V) Appendices F-I to Part 222...

  16. 10 CFR Appendices A-B to Subpart F... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false A Appendices A-B to Subpart F of Part 430 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CONSERVATION PROGRAM FOR CONSUMER PRODUCTS Reserved Appendices A-B to Subpart F of Part 430...

  17. 10 CFR Appendices A-B to Subpart F... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false A Appendices A-B to Subpart F of Part 430 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CONSERVATION PROGRAM FOR CONSUMER PRODUCTS Reserved Appendices A-B to Subpart F of Part 430...

  18. 10 CFR Appendices A-B to Subpart F... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false A Appendices A-B to Subpart F of Part 430 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CONSERVATION PROGRAM FOR CONSUMER PRODUCTS Reserved Appendices A-B to Subpart F of Part 430...

  19. 14 CFR Appendices I-J to Part 121 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false I Appendices I-J to Part 121 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND... SUPPLEMENTAL OPERATIONS Appendices I-J to Part 121...

  20. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How are IRR Program projects and activities included in a... Contracts and Agreements Under Isdeaa § 170.623 How are IRR Program projects and activities included in a self-governance agreement? To include an IRR Program project or activity in a self-governance...

  1. Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.

    PubMed

    Fisher, Melanie C; Li, Yingcui; Seghatoleslami, M Reza; Dealy, Caroline N; Kosher, Robert A

    2006-01-01

    Bone morphogenetic proteins (BMPs) are involved in multiple aspects of limb development including regulation of cartilage differentiation. Several BMPs bind strongly to heparin, and heparan sulfate proteoglycans (HSPGs) at the cell surface or in the extracellular matrix have recently been implicated as modulators of BMP signaling in some developing systems. Here we have explored the role of HSPGs in regulating BMP activity during limb chondrogenesis by evaluating the effects of exogenous heparan sulfate (HS), heparitinase treatment, and overexpression of the HSPG syndecan-3 on the ability of BMP2 to modulate the chondrogenic differentiation of limb mesenchymal cells in micromass culture. Exogenous HS dramatically enhances the ability of BMP2 to stimulate chondrogenesis and cartilage specific gene expression, and reduces the concentration of BMP2 needed to stimulate chondrogenesis. Furthermore, HS stimulates BMP2-mediated phosphorylation of Smad1, Smad5, and Smad8, transcriptional mediators of BMP2 signaling, indicating that HS enhances the interaction of BMP2 with its receptors. Pretreatment of micromass cultures with heparitinase to degrade endogenous HSPGs also enhances the chondrogenic activity of BMP2, and reduces the concentration of BMP2 needed to promote chondrogenesis. Taken together these results indicate that exogenous HS or heparitinase enhance the chondrogenic activity of BMP2 by interfering with its interaction with endogenous HSPGs that would normally restrict its interaction with its receptors. Consistent with the possibility that HSPGs are negative modulators of BMP signaling during chondrogenesis, we have found that overexpression of syndecan-3, which is one of the major HSPGs normally expressed during chondrogenesis, greatly impairs the ability of BMP2 to promote cartilage differentiation. Furthermore, retroviral overexpression of syndecan-3 inhibits BMP2-mediated Smad phosphorylation in the regions of the cultures in which chondrogenesis is

  2. [Acute abdomen secondary to appendiceal intussusception].

    PubMed

    Betancourth-Alvarenga, J E; Vázquez-Rueda, F; Murcia-Pascual, F J; Ayala-Montoro, J

    2015-01-01

    Appendiceal intussusception is a rare condition that can occur at any age. Only a few cases have been reported, and most are found during surgery. The therapeutic approach is usually surgical, ranging from an appendectomy to a hemicolectomy, primarily for biopsy and to rule out possible malignancy. Three cases of children under 14 years who underwent surgery for acute abdominal pain located in the right iliac fossa are presented; one with preoperative diagnosis by ultrasound, and the other two with positive intraoperative findings of intussusception of the cecal appendix, with acute appendicitis being histologically confirmed.

  3. Rectal and appendiceal inflammatory myofibroblastic tumors.

    PubMed

    Khoddami, Maliheh; Sanae, Shahram; Nikkhoo, Bahram

    2006-07-01

    Inflammatory myofibroblastic tumors are neoplasms characterized by spindle cell proliferation and a fiboinflammatory vascular stroma. Herein, we presented the successful treatment of a rectal inflammatory myofibroblastic tumor in an 11-year-old boy who presented with diarrhea and abdominal pain of 1(1/2) months duration and an appendiceal inflammatory myofibroblastic tumor in a 29-year-old man presented with recurrent abdominal pain of two months duration with associated tenderness and rebound tenderness in the right lower abdomen. Histologically, our cases had inflammatory myofibroblastic tumors very similar to that of other sites; the spindle cells were positive for vimentin and muscle-specific actin.

  4. Soldier Data Tag Study Effort. Appendices,

    DTIC Science & Technology

    1985-06-10

    84-C-0146 on ,.a. SOLDIER DATA TAG " -:.,r .* STUDY EFFORT I T IT t APPENDICES to U.S. Army Soldier Support Center ATZI /ODS (Mr. Occhialini) Fort...SUPPORT CENTER * P2 DEN HARRISON, IN 46216 11 -:NG QVFZF N UAE AND ADORESS i REPORT DATE ATZI --DDS (MR. OCCHIALINI) JN 13 WAMSEROF PAGES 7-4 .’,kT N...Memorandum ATZI -DDS (14 Sep. 83) Subject: Input Requirements for SDT Cost/Benefits Analysis (CBA) , To Ch, Ofc of Analysis Spt From C, SDT, Date 5 Oct. 83

  5. Resource Programs : Draft Environmental Impact Statement, Volume 2, Appendices.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-03-01

    Every two years, Bonneville Power Administration (BPA) prepares a Resource Program which identifies the resource actions BPA will take to meet its obligation to serve the forecasted power requirements of its customers. The Resource Program`s Environmental Impact Statement (RPEIS) is a programmatic environmental document which will support decisions made in several future Resource Programs. Environmental documents tiered to the EIS may be prepared on a site-specific basis. The RPEIS includes a description of the environmental effects and mitigation for the various resource types available in order to evaluate the trade-offs among them. It also assesses the environmental impacts of adding thirteen alternative combinations of resources to the existing power system. This report contains the appendices to the RPEIS.

  6. Development of a high-temperature heat pump grain dryer: Volume II. Appendices. Final report, September 6, 1979-September 30, 1981

    SciTech Connect

    Hogan, M.R.; Ayers, D.L.; Foster, G.H.

    1981-01-01

    Appendices are presented to a program designated to design, fabricate, and test a high-temperature, continuous-flow, electrically-driven heat pump grain dryer as an alternative to conventional LPG-fueled units. Detailed information in the appendices include: heat pump design computer program related data; data reduction program listing; drying system specifications and performance information pertinent to the economic analysis; and equipment specification and cost. (MCW)

  7. Be BOLD: Encouraging Girls to Include Unstructured Bouts of Physical Activity into Daily Routines

    ERIC Educational Resources Information Center

    Hill, Kory; Williams, Gwynne M.

    2014-01-01

    Adolescent girls are less active than their male counterparts and physical activity levels tend to decline as one ages. One of the goals of concerned physical educators is to promote a physically active lifestyle and to teach skills and promote behaviors that will allow students to be active both in and out of school. This article presents a…

  8. Modelling of an activated primary settling tank including the fermentation process and VFA elutriation.

    PubMed

    Ribes, J; Ferrer, J; Bouzas, A; Seco, A

    2002-10-01

    A complete model of a primary settler including both sedimentation and biological processes is presented. It is a one-dimensional model based on the solids flux concept and the conservation of mass that uses the Takács model for the settling velocity, which is corrected by a compression function in the lower layers. The biological model is based on the ASM2 and enlarged with the fermentation model proposed by this research group. The settler was split in ten layers and the flux terms in the mass balance for each layer is obtained by means of the settling model. A pilot plant has been operated to study the primary sludge fermentation and volatile fatty acids (VFA) elutriation in a primary settler tank. The model has been tested with pilot plant experimental data with very good results. It has been able to simulate the VFA production in the settler and their elutriation with the influent wastewater for all the studied experiments. The developed model is easily applicable to secondary settlers and thickeners, also taking into account biological activity inside them.

  9. Measuring Outcomes in Adult Weight Loss Studies That Include Diet and Physical Activity: A Systematic Review

    PubMed Central

    Millstein, Rachel A.

    2014-01-01

    Background. Measuring success of obesity interventions is critical. Several methods measure weight loss outcomes but there is no consensus on best practices. This systematic review evaluates relevant outcomes (weight loss, BMI, % body fat, and fat mass) to determine which might be the best indicator(s) of success. Methods. Eligible articles described adult weight loss interventions that included diet and physical activity and a measure of weight or BMI change and body composition change. Results. 28 full-text articles met inclusion criteria. Subjects, settings, intervention lengths, and intensities varied. All studies measured body weight (−2.9 to −17.3 kg), 9 studies measured BMI (−1.1 to −5.1 kg/m2), 20 studies measured % body fat (−0.7 to −10.2%), and 22 studies measured fat mass (−0.9 to −14.9 kg). All studies found agreement between weight or BMI and body fat mass or body fat % decreases, though there were discrepancies in degree of significance between measures. Conclusions. Nearly all weight or BMI and body composition measures agreed. Since body fat is the most metabolically harmful tissue type, it may be a more meaningful measure of health change. Future studies should consider primarily measuring % body fat, rather than or in addition to weight or BMI. PMID:25525513

  10. WECC Variable Generation Planning Reference Book: Appendices

    SciTech Connect

    Makarov, Yuri V.; Du, Pengwei; Etingov, Pavel V.; Ma, Jian; Vyakaranam, Bharat

    2013-05-13

    The document titled “WECC Variable Generation Planning Reference Book”. This book is divided into two volumes; one is the main document (volume 1)and the other is appendices (volume 2). The main document is a collection of the best practices and the information regarding the application and impact of variables generation on power system planning. This volume (appendices) has additional information on the following topics: Probabilistic load flow problems. 2. Additional useful indices. 3. high-impact low-frequency (HILF) events. 4. Examples of wide-area nomograms. 5. Transmission line ratings, types of dynamic rating methods. 6. Relative costs per MW-km of different electric power transmission technologies. 7. Ultra-high voltage (UHV) transmission. 8.High voltage direct current (VSC-HVDC). 9. HVDC. 10. Rewiring of existing transmission lines. 11. High-temperature low sag (HTLS) conductors. 12. The direct method and energy functions for transient stability analysis in power systems. 13.Blackouts caused by voltage instability. 14. Algorithm for parameter continuation predictor-corrector methods. 15. Approximation techniques available for security regions. 16. Impacts of wind power on power system small signals stability. 17. FIDVR. 18. FACTS. 19. European planning standard and practices. 20. International experience in wind and solar energy sources. 21. Western Renewable Energy Zones (WREZ). 22. various energy storage technologies. 23. demand response. 24. BA consolidation and cooperation options. 25. generator power management requirements and 26. European planning guidelines.

  11. Appendiceal diverticulum associated with chronic appendicitis

    PubMed Central

    Zubieta-O’Farrill, Gregorio; Guerra-Mora, José Raúl; Gudiño-Chávez, Andrés; Gonzalez-Alvarado, Carlos; Cornejo-López, Gilberto Bernabe; Villanueva-Sáenz, Eduardo

    2014-01-01

    INTRODUCTION Appendiceal diverticulosis is a rare entity, with a global incidence between 0.004% and 2.1% of all appendectomies. It has been related with an elevated risk of perforation in comparison to acute appendicitis, as well as an increased risk for synchronic appendicular cancer in 48% of the cases, and colonic cancer in 43%. The incidence of chronic appendicitis has been reported in 1.5% of all appendicitis cases. PRESENTATION OF CASE We present a 73-year-old female, with no relevant familial history, who presented due to a four-month-long oppressive, moderate pain in the lower right abdominal quadrant without irradiation or any other accompanying symptoms. DISCUSSION The documented incidence of appendiceal diverticula and chronic appendicitis by themselves is low; therefore the presence of both entities at the same time is extremely rare. CONCLUSION We present a case in which both diagnoses concurred in the same patient. The relevance of this case relies on the importance of the adequate knowledge of these pathologies, so we can approach them correctly. Although it does not represent an absolute surgical emergency, appendectomy represents the first therapeutic option. PMID:25460447

  12. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  13. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  14. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  15. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  16. [Torsion and necrosis of epiploic appendices of the large bowel].

    PubMed

    Timofeev, M E; Fedorov, E D; Krechetova, A P; Shapoval'iants, S G

    2014-01-01

    The features of the clinical symptoms was studied, the possibility of laparoscopy in modern diagnosis and treatment of epiploic appendices torsion and necrosis of the large bowel was assessed in the article. It was done the retrospective analysis of the medical records of 87 patients with a diagnosis of epiploic appendices torsion and necrosis of the large bowel. The patients had laparoscopic operations in our hospital in the period from January 1995 to December 2012. The clinical picture, laboratory and instrumental datas in cases of epiploic appendices torsion and necrosis were scarce and nonspecific. An abdominal pain preferentially localized in the lower divisions was the main symptom (97.7%). The instrumental methods did not allow to diagnose the torsion and necrosis of epiploic appendices in the majority of cases and all these techniques were used for the differential diagnosis with other diseases. The assumption of the presence of appendices torsion and necrosis occured just in 34.5% of cases before the operation. Diagnosis of epiploic appendices torsion and necrosis present significant difficulties on prehospital and preoperative stages. The diagnostic laparoscopy is the method of choice in unclear situations and it allows to diagnose the torsion and necrosis of epiploic appendices in 96.6% of cases. Successful surgical treatment by using laparoscopic approach is possible in 90.8% of cases.

  17. Flight Simulation Model Exchange. Volume 2; Appendices

    NASA Technical Reports Server (NTRS)

    Murri, Daniel G.; Jackson, E. Bruce

    2011-01-01

    The NASA Engineering and Safety Center Review Board sponsored an assessment of the draft Standard, Flight Dynamics Model Exchange Standard, BSR/ANSI-S-119-201x (S-119) that was conducted by simulation and guidance, navigation, and control engineers from several NASA Centers. The assessment team reviewed the conventions and formats spelled out in the draft Standard and the actual implementation of two example aerodynamic models (a subsonic F-16 and the HL-20 lifting body) encoded in the Extensible Markup Language grammar. During the implementation, the team kept records of lessons learned and provided feedback to the American Institute of Aeronautics and Astronautics Modeling and Simulation Technical Committee representative. This document contains the appendices to the main report.

  18. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Sokolik, I. N.; Nenes, A.

    2008-09-01

    Dust and black carbon aerosol have long been known to have potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of such particles, and ignore interactions of the insoluble fraction with water vapor (even if known to be hydrophilic). To address this gap, we develop a new parameterization framework that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable) particles mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler Theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frankel-Halsey-Hill (FHH) adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory, and i) find combinations of the adsorption parameters AFHH, BFHH for which activation into cloud droplets is not possible, and, ii) express activation properties (critical supersaturation) that follow a simple power law with respect to dry particle diameter. Parameterization formulations are developed for sectional and lognormal aerosol size distribution functions. The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2 ~0.98.

  19. A Study of Operator and Mechnaic Training Needs in the Transit Industry. Volume II, Appendices. Final Report.

    ERIC Educational Resources Information Center

    Henderson, Harold L.; And Others

    Surveys of 188 transit properties and on-site visits were conducted to determine the training needs of operators and mechanics in the urban mass transportation industry. The appendices include listings of respondents and sample copies of the survey questionnaires and visit reports. (NTIS)

  20. Geothermal resource assessment for the state of Texas: status of progress, November 1980. Final report. Appendices E through H

    SciTech Connect

    Woodruff, C.M. Jr.; Caran, S.C.; Gever, C.; Henry, C.D.; Macpherson, G.L.; McBride, M.W.

    1982-03-01

    These appendices include: a folio of maps showing lineaments perceived across the state; an index and critique of the Landsat images used in perceiving the lineaments; a selected bibliography on lineaments; and a discussion of area-specific assessments of geothermal resources near military bases in Bexar, Travis, and Val Verde Counties. (MHR)

  1. Yucca Mountain transportation routes: Preliminary characterization and risk analysis; Volume 2, Figures [and] Volume 3, Technical Appendices

    SciTech Connect

    Souleyrette, R.R. II; Sathisan, S.K.; di Bartolo, R.

    1991-05-31

    This report presents appendices related to the preliminary assessment and risk analysis for high-level radioactive waste transportation routes to the proposed Yucca Mountain Project repository. Information includes data on population density, traffic volume, ecologically sensitive areas, and accident history.

  2. Diffractive laser beam homogenizer including a photo-active material and method of fabricating the same

    SciTech Connect

    Bayramian, Andy J; Ebbers, Christopher A; Chen, Diana C

    2014-05-20

    A method of manufacturing a plurality of diffractive optical elements includes providing a partially transmissive slide, providing a first piece of PTR glass, and directing first UV radiation through the partially transmissive slide to impinge on the first piece of PTR glass. The method also includes exposing predetermined portions of the first piece of PTR glass to the first UV radiation and thermally treating the exposed first piece of PTR glass. The method further includes providing a second piece of PTR glass and directing second UV radiation through the thermally treated first piece of PTR glass to impinge on the second piece of PTR glass. The method additionally includes exposing predetermined portions of the second piece of PTR glass to the second UV radiation, thermally treating the exposed second piece of PTR glass, and repeating providing and processing of the second piece of PTR glass using additional pieces of PTR glass.

  3. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... communication network), or portions of a web-site that target the farming or grower trade. (iii) For any... complementary product(s), or a handler selling multiple complementary products, including other nuts, with...

  4. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... communication network), or portions of a web-site that target the farming or grower trade. (iii) For any... complementary product(s), or a handler selling multiple complementary products, including other nuts, with...

  5. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... communication network), or portions of a web-site that target the farming or grower trade. (iii) For any... complementary product(s), or a handler selling multiple complementary products, including other nuts, with...

  6. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How are IRR Program projects and activities included in a self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  7. Electrode including porous particles with embedded active material for use in a secondary electrochemical cell

    DOEpatents

    Vissers, Donald R.; Nelson, Paul A.; Kaun, Thomas D.; Tomczuk, Zygmunt

    1978-04-25

    Particles of carbonaceous matrices containing embedded electrode active material are prepared for vibratory loading within a porous electrically conductive substrate. In preparing the particles, active materials such as metal chalcogenides, solid alloys of alkali or alkaline earth metals along with other metals and their oxides in powdered or particulate form are blended with a thermosetting resin and particles of a volatile to form a paste mixture. The paste is heated to a temperature at which the volatile transforms into vapor to impart porosity at about the same time as the resin begins to cure into a rigid, solid structure. The solid structure is then comminuted into porous, carbonaceous particles with the embedded active material.

  8. In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.

    PubMed

    Fujisaki, Ryuichi; Kamei, Kiyoko; Yamamura, Mariko; Nishiya, Hajime; Inouye, Shigeharu; Takahashi, Miki; Abe, Shigeru

    2012-03-01

    Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values.

  9. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Sokolik, I. N.; Nenes, A.

    2009-04-01

    Dust and black carbon aerosol have long been known to exert potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of these particles, and overlook interactions of the insoluble fraction with water vapor (even if known to be hydrophilic). To address this gap, we developed a new parameterization that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable) particles externally mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frenkel-Halsey-Hill (FHH) adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory to i) find combinations of the adsorption parameters AFHH, BFHH which yield atmospherically-relevant behavior, and, ii) express activation properties (critical supersaturation) that follow a simple power law with respect to dry particle diameter. The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2~0.98. A preliminary sensitivity study suggests that the sublinear response of droplet number to Köhler particle concentration is not as strong for FHH particles.

  10. Mechanical intestinal obstruction secondary to appendiceal mucinous cystadenoma

    PubMed Central

    Xu, Zheng-shui; Xu, Wei; Ying, Jia-qi; Cheng, Hua

    2017-01-01

    Abstract Background: Appendiceal mucinous cystadenoma can present in various ways, and it is most commonly encountered incidentally during appendectomy, but mechanical intestinal obstruction secondary to an appendiceal mucocele has been rarely reported. Methods: We report a case of mechanical intestinal obstruction secondary to appendiceal mucinous cystadenoma. After nasogastric decompression and initial aggressive intravenous fluid resuscitation, an emergency operation was performed under the diagnosis of acute mechanical intestinal obstruction. Results: We performed an appendectomy and intraoperative enteral decompression without anastomoses. The pathologic examination (PE) revealed appendiceal mucinous cystadenoma. After the operation, the patient's recovery went smoothly, and the patient was discharged on the fifth postoperative day. No tumor recurrence was recorded over an 8 month follow-up period. Conclusion: Early operative intervention should be recommended to the patient with acute mechanical complete intestinal obstruction, especially the patient who had no previous abdominal surgery. And it is vital to discriminate benign and malignantappendiceal mucocel in determining the extent of surgery. PMID:28151903

  11. Observing a fictitious stressful event: haematological changes, including circulating leukocyte activation.

    PubMed

    Mian, Rubina; Shelton-Rayner, Graham; Harkin, Brendan; Williams, Paul

    2003-03-01

    The aim of this study was to assess the effect of watching a psychological stressful event on the activation of leukocytes in healthy human volunteers. Blood samples were obtained from 32 healthy male and female subjects aged between 20 and 26 years before, during and after either watching an 83-minute horror film that none of the subjects had previously seen (The Texas Chainsaw Massacre, 1974) or by sitting quietly in a room (control group). Total differential cell counts, leukocyte activation as measured by the nitroblue tetrazolium (NBT) test, heart rate and blood pressure (BP) measurements were taken at defined time points. There were significant increases in peripheral circulating leukocytes, the number of activated circulating leukocytes, haemoglobin (Hb) concentration and haematocrit (Hct) in response to the stressor. These were accompanied by significant increases in heart rate, systolic and diastolic BP (P<0.05 from baseline). This is the first reported study on the effects of observing a psychologically stressful, albeit fictitious event on circulating leukocyte numbers and the state of leukocyte activation as determined by the nitrotetrazolium test.

  12. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities and Bibliography.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population concerns. Designed to educate general college audiences, it is also intended for use as a preservice course for teachers. In addition, the course can be modified for high school students. The course…

  13. Beyond Right or Wrong: Challenges of Including Creative Design Activities in the Classroom

    ERIC Educational Resources Information Center

    Brennan, Karen

    2015-01-01

    In this article, we explore challenges encountered by K-12 educators in establishing classroom cultures that support creative learning activities with the Scratch programming language. Providing opportunities for students to understand and to build capacities for creative work was described by many of the teachers that we interviewed as a central…

  14. Sixty Minutes of Physical Activity per Day Included within Preschool Academic Lessons Improves Early Literacy

    ERIC Educational Resources Information Center

    Kirk, Stacie M.; Kirk, Erik P.

    2016-01-01

    Background: The effects of increases in physical activity (PA) on early literacy skills in preschool children are not known. Methods: Fifty-four African-American preschool children from a low socioeconomic urban Head Start participated over 8 months. A 2-group, quasi-experimental design was used with one preschool site participating in the PA…

  15. Using assistive technology adaptations to include students with learning disabilities in cooperative learning activities.

    PubMed

    Bryant, D P; Bryant, B R

    1998-01-01

    Cooperative learning (CL) is a common instructional arrangement that is used by classroom teachers to foster academic achievement and social acceptance of students with and without learning disabilities. Cooperative learning is appealing to classroom teachers because it can provide an opportunity for more instruction and feedback by peers than can be provided by teachers to individual students who require extra assistance. Recent studies suggest that students with LD may need adaptations during cooperative learning activities. The use of assistive technology adaptations may be necessary to help some students with LD compensate for their specific learning difficulties so that they can engage more readily in cooperative learning activities. A process for integrating technology adaptations into cooperative learning activities is discussed in terms of three components: selecting adaptations, monitoring the use of the adaptations during cooperative learning activities, and evaluating the adaptations' effectiveness. The article concludes with comments regarding barriers to and support systems for technology integration, technology and effective instructional practices, and the need to consider technology adaptations for students who have learning disabilities.

  16. Physical Activity Programs in Higher Education: Modifying Net/Wall Games to Include Individuals with Disabilities

    ERIC Educational Resources Information Center

    Braga, Luciana; Tracy, Julia F.; Taliaferro, Andrea R.

    2015-01-01

    The growing number of students with disabilities in higher education settings has presented challenges for instructors with regards to appropriate inclusion. Concerning physical activity courses in higher education, instructors may not have the knowledge or resources to make modifications and accommodations that will ultimately result in…

  17. An Updated Review of Interventions that Include Promotion of Physical Activity for Adult Men.

    PubMed

    Bottorff, Joan L; Seaton, Cherisse L; Johnson, Steve T; Caperchione, Cristina M; Oliffe, John L; More, Kimberly; Jaffer-Hirji, Haleema; Tillotson, Sherri M

    2015-06-01

    The marked disparity in life expectancy between men and women suggests men are a vulnerable group requiring targeted health promotion programs. As such, there is an increasing need for health promotion strategies that effectively engage men with their health and/or illness management. Programs that promote physical activity could significantly improve the health of men. Although George et al. (Sports Med 42(3):281, 30) reviewed physical activity programs involving adult males published between 1990 and 2010, developments in men's health have prompted the emergence of new sex- and gender-specific approaches targeting men. The purpose of this review was to: (1) extend and update the review undertaken by George et al. (Sports Med 42(3):281, 30) concerning the effectiveness of physical activity programs in males, and (2) evaluate the integration of gender-specific influences in the content, design, and delivery of men's health promotion programs. A search of MEDLINE, CINAHL, ScienceDirect, Web of Science, PsycINFO, the Cochrane Library, and the SPORTDiscus databases for articles published between January 2010 and August 2014 was conducted. In total, 35 studies, involving evaluations of 31 programs, were identified. Findings revealed that a variety of techniques and modes of delivery could effectively promote physical activity among men. Though the majority of programs were offered exclusively to men, 12 programs explicitly integrated gender-related influences in male-specific programs in ways that recognized men's interests and preferences. Innovations in male-only programs that focus on masculine ideals and gender influences to engage men in increasing their physical activity hold potential for informing strategies to promote other areas of men's health.

  18. Space Resources for Teachers: Biology, Including Suggestions for Classroom Activities and Laboratory Experiments.

    ERIC Educational Resources Information Center

    Lee, Tom E.; And Others

    This compilation of resource units concerns the latest developments in space biology. Some of the topics included are oxygen consumption, temperature, radiation, rhythms, weightlessness, acceleration and vibration stress, toxicity, and sensory and perceptual problems. Many of the topics are interdisciplinary and relate biology, physiology,…

  19. Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity

    PubMed Central

    2013-01-01

    Background Ursodeoxycholic acid (UDCA) is used to treat primary biliary cirrhosis, intrahepatic cholestasis, and other cholestatic conditions. Although much has been learned about the molecular basis of the disease pathophysiology, our understanding of the effects of UDCA remains unclear. Possibly underlying its cytoprotective, anti-apoptotic, anti-oxidative effects, UDCA was reported to regulate the expression of TNFα and other inflammatory cytokines. However, it is not known if this effect involves also modulation of ADAM family of metalloproteinases, which are responsible for release of ectodomains of inflammatory cytokines from the cell surface. We hypothesized that UDCA modulates ADAM17 activity, resulting in amelioration of cholestasis in a murine model of bile duct ligation (BDL). Methods The effect of UDCA on ADAM17 activity was studied using the human liver hepatocellular carcinoma cell line HepG2. Untransfected cells or cells ectopically expressing human ADAM17 were cultured with or without UDCA and further activated using phorbol-12-myristate-13-acetate (PMA). The expression and release of ADAM17 substrates, TNFα, TGFα, and c-Met receptor (or its soluble form, sMet) were evaluated using ELISA and quantitative real-time (qRT) PCR. Immunoblotting analyses were conducted to evaluate expression and activation of ADAM17 as well as the level of ERK1/2 phosphorylation after UDCA treatment. The regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) by UDCA was studied using zymography and qRT-PCR. A mouse model of acute cholestasis was induced by common BDL technique, during which mice received daily orogastric gavage with either UDCA or vehicle only. Liver injury was quantified using alkaline phosphatase (ALP), relative liver weight, and confirmed by histological analysis. ADAM17 substrates in sera were assessed using a bead multiplex assay. Results UDCA decreases amount of shed TNFα, TGFα, and sMet in cell culture media and the phosphorylation of

  20. A spatial model of cellular molecular trafficking including active transport along microtubules.

    PubMed

    Cangiani, A; Natalini, R

    2010-12-21

    We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.

  1. Appendicitis in Cancer Patients Is Often Observed and Can Represent Appendiceal Malignancy.

    PubMed

    Santos, David; Chiang, Yi-Ju; Badgwell, Brian

    2016-10-01

    Appendectomy is standard of care for uncomplicated appendicitis, but cancer patients may not be optimal surgical candidates. Interval appendectomy is controversial, and appendiceal malignancy is rare. Study objectives were to review the role of surgery, observation, and interventional radiology (IR)-guided drainage in patients with appendicitis and advanced malignancy. Retrospective review was performed on cancer patients presenting to a tertiary academic cancer center from January 1, 2001 to December 31, 2014. Patients diagnosed with appendicitis were assigned to observation, surgery, and IR drainage after surgical evaluation. Success rates of initial treatment strategies were calculated. Rates of interval appendectomies and pathology were reviewed. Of 72 consults, 32 patients were included. Median age was 53 years, 50 per cent (16/32) were male, 50 per cent (16/32) had chemotherapy less than six weeks to presentation, and 63 per cent (20/32) had advanced stage malignancy. Of the 62.5 per cent (20/32) observed, 25 per cent (8/32) received immediate surgery, 12.5 per cent (4/32) required IR drainage, and 69 per cent (22/32) of patients were initially managed without surgery. Interval appendectomy rate was 19 per cent (6/32). Pathology confirmed appendiceal malignancies in 9.3 per cent (3/32). Cancer patients with acute appendicitis are frequently observed. High incidence of appendiceal malignancy may be due to the older median age. Interval appendectomy should be considered in this population.

  2. A Methodology for Post Operational Clean Out of a Highly Active Facility Including Solids Behaviour - 12386

    SciTech Connect

    Edmondson, Michael J.; Ward, Tracy R.; Maxwell, Lisa J.

    2012-07-01

    The Highly Active Liquor Evaporation and Storage (HALES) plant at Sellafield handles acidic fission product containing liquor with typical activities of the order of 18x10{sup 9} Bq/ml. A strategy experimental feedback approach has been used to establish a wash regime for the Post Operational Clean Out (POCO) of the oldest storage tanks for this liquor. Two different wash reagents have been identified as being potentially suitable for removal of acid insoluble fission product precipitates. Ammonium carbamate and sodium carbonate yield similar products during the proposed wash cycle. The proposed wash reagents provide dissolution of caesium phosphomolybdate (CPM) and zirconium molybdate (ZM) solid phases but yields a fine, mobile precipitate of metal carbonates from the Highly Active Liquor (HAL) supernate. Addition of nitric acid to the wash effluent can cause CPM to precipitate where there is sufficient caesium and phosphorous available. Where they are not present (from ZM dissolution) the nitric acid addition initially produces a nitrate precipitate which then re-dissolves, along with the metal carbonates, to give a solid-free solution. The different behaviour of the two solids during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing the rheology of ZM sediments through doping with tellurium or particular organic acids. Two different wash reagents have been identified as being potentially suitable for the POCO of HALES Oldside HASTs. AC and SC both yield similar products during the proposed wash cycle. However, the different behaviour of the two principle HAL solids, CPM and ZM, during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing its rheology through doping with tellurium or certain

  3. Steady-state analysis of activated sludge processes with a settler model including sludge compression.

    PubMed

    Diehl, S; Zambrano, J; Carlsson, B

    2016-01-01

    A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration.

  4. Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

    SciTech Connect

    Michael Kruzic

    2007-09-01

    Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolition (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.

  5. LIPID PEROXIDATION GENERATES BIOLOGICALLY ACTIVE PHOSPHOLIPIDS INCLUDING OXIDATIVELY N-MODIFIED PHOSPHOLIPIDS

    PubMed Central

    Davies, Sean S.; Guo, Lilu

    2014-01-01

    Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease. PMID:24704586

  6. [Development of asymmetric synthesis of optically active compounds including fluoroorganic molecules].

    PubMed

    Iseki, K

    1999-11-01

    The synthesis of chiral fluorinated molecules is important in the biological and medicinal chemistry fields in view of the influence of fluorine's unique properties on biological activity. In recent years, we have studied asymmetric synthesis focussing on such optically active compounds. This review describes 1) diastereoselective trifluoromethylation of chiral N-acyloxazolidinones, 2) catalytic enantioselective aldol reactions of fluorine-substituted ketene silyl acetals, and 3) catalytic enantioselective allylation of aldehydes mediated by chiral Lewis bases. The trifluoromethylation of lithium enolates of N-acyloxazolidinones with iodotrifluoromethane is mediated by triethylborane to give the corresponding trifluoromethylated products with up to 86% diastereomeric excess. The stereoselective reaction is considered to proceed through the attack of the trifluoromethyl radical on the less hindered face of the lithium imide. Difluoroketene and bromofluoroketene trimethylsilyl ethyl acetals react with various aldehydes in the presence of chiral Lewis acids to afford the corresponding desired aldols with up to 99% enantiomeric excess (ee). It is noteworthy that the aldol reactions of the fluorine-substituted acetals at -78 degrees C and at higher temperatures (-45 or -20 degrees C) provide the (+)- and (-)-aldols, respectively, with excellent-to-good enantioselectivity. Chiral phosphoramides newly prepared from (S)-proline were found to catalyze the allylation and crotylation of aromatic aldehydes with allylic trichlorosilanes in good enantioselective yields (up to 90% ee). (S,S)-Bis(alpha-methylbenzyl)formamide developed as an efficient catalyst for the allylation and crotylation of aliphatic aldehydes mediates the enantioselective addition with the assistance of hexamethylphosphoramide (HMPA) to afford the corresponding homoallylic alcohols in up to 98% ee.

  7. Ozone control of biological activity during Earth's history, including the KT catastrophe

    NASA Technical Reports Server (NTRS)

    Sheldon, W. R.

    1994-01-01

    There have been brief periods since the beginning of the Cambrian some 600 m.y. ago when mass extinctions destroyed a significant fraction of living species. The most widely studied of these events is the catastrophe at the KT boundary that ended the long dominance of the dinosaurs. In addition to mass extinctions, there is another profound discontinuity in the history of Earth's biota, the explosion of life at the end of the Precambrian era which is an episode that is not explained well at all. For some 3 b.y. before the Cambrian, life had been present on Earth, but maintained a low level of activity which is an aspect of the biota that is puzzling, especially during the last two-thirds of that period. During the last 2 b.y. before the Cambrian, conditions at the Earth's surface were suitable for a burgeoning of the biota, according to most criteria: the oceans neither boiled nor were fozen solid during this time, and the atmosphere contained sufficient O for the development of animals. The purpose of this paper is to suggest that mass extinctions and the lackluster behavior of the Precambrian biota share a common cause: an inadequate amount of ozone in the atmosphere.

  8. Design of a high-lift experiment in water including active flow control

    NASA Astrophysics Data System (ADS)

    Beutel, T.; Sattler, S.; El Sayed, Y.; Schwerter, M.; Zander, M.; Büttgenbach, S.; Leester-Schädel, M.; Radespiel, R.; Sinapius, M.; Wierach, P.

    2014-07-01

    This paper describes the structural design of an active flow-control experiment. The aim of the experiment is to investigate the increase in efficiency of an internally blown Coanda flap using unsteady blowing. The system uses tailor-made microelectromechanical (MEMS) pressure sensors to determine the state of the oncoming flow and an actuated lip to regulate the mass flow and velocity of a stream near a wall over the internally blown flap. Sensors and actuators are integrated into a highly loaded system that is extremely compact. The sensors are connected to a bus system that feeds the data into a real-time control system. The piezoelectric actuators using the d 33 effect at a comparable low voltage of 120 V are integrated into a lip that controls the blowout slot height. The system is designed for closed-loop control that efficiently avoids flow separation on the Coanda flap. The setup is designed for water-tunnel experiments in order to reduce the free-stream velocity and the system’s control frequency by a factor of 10 compared with that in air. This paper outlines the function and verification of the system’s main components and their development.

  9. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase

    PubMed Central

    Sahonero-Canavesi, Diana X.; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M.; Geiger, Otto

    2016-01-01

    Summary Phospholipids are well known for their membrane forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth. PMID:25711932

  10. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase.

    PubMed

    Sahonero-Canavesi, Diana X; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M; Geiger, Otto

    2015-09-01

    Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth.

  11. Dysplastic intestinal-type metaplasia of appendiceal endometriosis: a mimic of low grade appendiceal mucinous neoplasm

    PubMed Central

    2014-01-01

    We report an example of dysplastic intestinal-type metaplasia involving endometriosis of the appendix in a 45 year old woman. One other example of this phenomenon has been reported. As it occurs within the muscular wall of the appendix, confusion with low grade appendiceal mucinous neoplasm (LAMN) may occur. Evidence supporting the metaplastic nature of the intestinal epithelium is offered. As the initial pathological diagnosis was of invasive cancer with perforation of the appendix treatment consisted of peritonectomy and hyperthermic intraperitoneal chemotherapy (HIPEC). Virtual slides The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1068246472111756. PMID:24559059

  12. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  13. 14 CFR 440.11 - Duration of coverage for licensed launch, including suborbital launch, or permitted activities...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Duration of coverage for licensed launch, including suborbital launch, or permitted activities; modifications. 440.11 Section 440.11 Aeronautics and... Duration of coverage for licensed launch, including suborbital launch, or permitted...

  14. Clinical experience in appendiceal neuroendocrine neoplasms

    PubMed Central

    Ozcelik, Caglar K.; Bozdogan, Nazan; Dibekoglu, Cengiz

    2015-01-01

    Aim of the study To analyse the incidence of appendiceal neuroendocrine neoplasms in appendectomy specimens and establish the epidemiological and histopathological features, treatment, and clinical course. Material and methods Between 2004 and 2013, 975 patients who underwent appendectomy in Ankara Oncology Education and Research Hospital were retrospectively analysed. Results Neuroendocrine neoplasm was detected in the nine of 975 (0.9%) patients. Neuroendocrine neoplasms were diagnosed in eight patients by appendectomy, which was performed because of the prediagnosis of acute appendicitis, and in one patient by the suspicious mass detection during surgical procedures that were done in the appendix for a different reason. Eight of the patients’ tumours were in the tip of the appendix, and one of the patients’ tumours was at the base of appendix. Tumour size in 77.8% of patients was equal or less than 1 cm, in 22.2% patients it was 1–2 cm. There was tumour invasion in the muscularis propria layer in four patients, in the serosa layer in three patients, and in the deep mesoappendix in two patients. Patients were followed for a median of 78 months. In the follow-up of patients who were operated because of colon cancer, metachronous colon tumour evolved. This patient died due to progressive disease. Other patients are still disease-free. Conclusions The diagnosis of neuroendocrine neoplasm is often incidentally done after appendectomy. Tumour size is important in determining the extent of disease and in the selection of the surgical method during operation. PMID:26793027

  15. Should Physical Activity Be Included in Nutrition Education? A Comparison of Nutrition Outcomes with and without In-Class Activities

    ERIC Educational Resources Information Center

    Palmer-Keenan, Debra M.; Corda, Kirsten

    2014-01-01

    Limited-resource adults' dietary intakes and nutrition behaviors improve as a result of Expanded Food and Nutrition Education Program (EFNEP)/Supplemental Nutrition Assistance Program Education (SNAP-Ed) participation; however, physical activity education is needed for improved health. The experimental study reported here assessed if spending time…

  16. The total assessment profile, volume 2. [including societal impact, cost effectiveness, and economic analysis

    NASA Technical Reports Server (NTRS)

    Leininger, G.; Jutila, S.; King, J.; Muraco, W.; Hansell, J.; Lindeen, J.; Franckowiak, E.; Flaschner, A.

    1975-01-01

    Appendices are presented which include discussions of interest formulas, factors in regionalization, parametric modeling of discounted benefit-sacrifice streams, engineering economic calculations, and product innovation. For Volume 1, see .

  17. Environment, safety and health progress assessment manual. Volume 2, Appendices

    SciTech Connect

    Not Available

    1992-12-01

    On June 27, 1989, the Secretary of Energy announced a 1O-Point Initiative to strengthen environment,safety, and health (ES&H) programs, and waste management activities at involved conducting DOE production, research, and testing facilities. One of the points independent Tiger Team Assessments of DOE operating facilities. The Office of Special Projects (OSP), EH-5, in the Office of the Assistant Secretary for Environment, Safety and Health, EH-1, was assigned the responsibility to conduct the Tiger Team Assessments. Through June 1992, a total of 35 Tiger Team Assessments were completed. The Secretary directed that Corrective Action Plans be developed and implemented to address the concerns identified by the Tiger Teams. In March 1991, the Secretary approved a plan for assessments that are ``more focused, concentrating on ES&H management, ES&H corrective actions, self-assessment programs, and root-cause related issues.`` In July 1991, the Secretary approved the initiation of ES&H Progress Assessments, as a followup to the Tiger Team Assessments, and in the continuing effort to institutionalize the self-assessment process and line management accountability in the ES&H areas. This volume contains appendices to the Environment, Safety and Health Progress Assessment Manual.

  18. Transportation Sector Model of the National Energy Modeling System. Volume 2 -- Appendices: Part 1

    SciTech Connect

    1998-01-01

    This volume contains input data and parameters used in the model of the transportation sector of the National Energy Modeling System. The list of Transportation Sector Model variables includes parameters for the following: Light duty vehicle modules (fuel economy, regional sales, alternative fuel vehicles); Light duty vehicle stock modules; Light duty vehicle fleet module; Air travel module (demand model and fleet efficiency model); Freight transport module; Miscellaneous energy demand module; and Transportation emissions module. Also included in these appendices are: Light duty vehicle market classes; Maximum light duty vehicle market penetration parameters; Aircraft fleet efficiency model adjustment factors; and List of expected aircraft technology improvements.

  19. Swan Hills Special Waste Treatment Centre human health impact assessment. Volume 2: Technical appendices

    SciTech Connect

    1997-12-31

    Appendices to a study of human health impacts of the Swan Hills Waste Treatment Centre in Alberta include: Background information on the Centre, including site characteristics, operational history, environmental incidents, and land use; protocols for sampling of locally obtained meat and fish; data on levels of polychlorinated biphenyls and dioxins in meat and fish samples; protocols for human blood monitoring and sampling; congener profiles for deer, fish, and human blood samples; survey questionnaires and news releases related to possible impacts of a contaminant release from the Centre; and information on databases used.

  20. Swan Hills Special Waste Treatment Centre human health impact assessment. Volume 2: Technical appendices

    SciTech Connect

    Not Available

    1997-01-01

    Appendices to a study of human health impacts of the Swan Hills Waste Treatment Centre in Alberta include: Background information on the Centre, including site characteristics, operational history, environmental incidents, and land use; protocols for sampling of locally obtained meat and fish; data on levels of polychlorinated biphenyls and dioxins in meat and fish samples; protocols for human blood monitoring and sampling; congener profiles for deer, fish, and human blood samples; survey questionnaires and news releases related to possible impacts of a contaminant release from the Centre; and information on databases used.

  1. Appendiceal carcinoid tumor in children: implications for less radical surgery?

    PubMed

    Malkan, A D; Wahid, F N; Fernandez-Pineda, I; Sandoval, J A

    2015-03-01

    The discovery of an appendiceal carcinoid tumor found incidentally or during the course of diagnostic or therapeutic procedures is a burden to both the patient and clinician. The role of the correct surgical operation is paramount for lesions suspected to be malignant. In the pediatric population, appendiceal carcinoids continue to challenge the clinician in choosing the optimal treatment when lesions are larger than 2 cm or involve the appendical base. While the criteria used to define these distinct lesions are available in most cases, the management and treatment are still debated and controversial when considering more radical surgical intervention. The purpose of this article is to give an overview regarding the history, diagnosis, histopathology, management, and controversies associated with appendiceal carcinoid in the pediatric population.

  2. Effects of Leisure Education Programme Including Sportive Activities on Perceived Freedom in Leisure of Adolescents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Ertuzun, Ezgi

    2015-01-01

    The objective of this experimental study is to determine the effect of leisure education programme including sportive activities on the perceived freedom in leisure of adolescents with mild intellectual disabilities. The research was designed with an experimental group (n = 37) and a control group (n = 34), and was conducted among a total of 71…

  3. United States Air Force 611th Air Support Group/Civil Engineering Squadron Elmendorf AFB, Alaska. Remedial investigation and feasibility study. Barter Island Radar Installation, Alaska. Volume 1 (includes appendices a through c). Revision 1. Final report, January 1995-January 1996

    SciTech Connect

    Karmi, S.; Madden, J.; Borsetti, R.

    1996-01-05

    This report presents the findings of Remedial Investigations and Feasibility Studies at sites located at the Barter Island radar installation in northern Alaska. The sites were characterized based on sampling and analyses conducted during Remedial Investigation activities performed during August and September 1993.

  4. Quantification of Libby Reservoir Levels Needed to Maintain or Enhance Reservoir Fisheries, Appendices, 1984 Annual Report.

    SciTech Connect

    Shepard, Bradley B.

    1985-06-01

    The appendices include: (1) stream habitat inventory procedures; (2) lengths and volumes across hydroacoustic transects in Libby Reservoir; (3) temperature, pH, dissolved oxygen, and conductivity profiles in Libby Reservoir; (4) habitat survey information by reach; (5) gill net catches by species; (6) annual catches of fish in floating gill nets; (7) vertical distributions of fish and zooplankton; (8) timing of juvenile and adult movement through traps; (9) food habits information for collected fish; (10) estimated densities and composition of zooplankton by genera; (11) seasonal catch of macroinvertebrates; and (12) initial modeling effort on the Libby Reservoir fishery. (ACR)

  5. Technology, safety, and costs of decommissioning reference nuclear research and test reactors. Appendices

    SciTech Connect

    Konzek, G.J.; Ludwick, J.D.; Kennedy, W.E. Jr.; Smith, R.I.

    1982-03-01

    Safety and Cost Information is developed for the conceptual decommissioning of two representative licensed nuclear research and test reactors. Three decommissioning alternatives are studied to obtain comparisons between costs (in 1981 dollars), occupational radiation doses, potential radiation dose to the public, and other safety impacts. The alternatives considered are: DECON (immediate decontamination), SAFSTOR (safe storage followed by deferred decontamination), and EMTOMB (entombment). The study results are presented in two volumes. Volume 2 (Appendices) contains the detailed data that support the results given in Volume 1, including unit-component data.

  6. Fatigue Technology Assessment and Strategies for Fatigue Avoidance in Marine Structures. Appendices

    DTIC Science & Technology

    1993-01-01

    avoidance strategies based upon variables that contribute to the uncertainties of fatigue life. This set of Appendices includes more in-depth presentations...and Scott-Wiegel Spectra A.4 SELECTING A WAVE SPECTRUM A.4.1 Wave Hindcasting A.4.2 Direct Wave Measurements A.5 WAVE SCATTER DIAGRAM A.6 WAVE...Fourier series. N n(t) = I cos(wi*t+,i)1=1 where n(t) is the water surface elevation measured from still water level, at is the amplitude of each component

  7. Constellation Program (CxP) Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS) Independent Design Reliability Assessment. Volume 2; Appendices

    NASA Technical Reports Server (NTRS)

    Kelly, Michael J.

    2010-01-01

    This document contains the Appendices to the report documenting the activities, findings, and NASA Engineering and Safety Center (NESC) recommendations of a multidiscipline team to independently assess the Constellation Program (CxP) Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS). The assessment occurred during a period of 15 noncontiguous months between December 2008 and April 2010, prior to the CPAS Project's Preliminary Design Review (PDR) in August 2010.

  8. Uncertainty in future global energy use and fossil fuel CO{sub 2} emissions 1975 to 2075: Appendices C--F

    SciTech Connect

    Edmonds, J.A.; Reilly, J.M.; Gardner, R.H.; Brenkert, A.

    1985-12-01

    In constructing the model, creating variable names, and linking the model to the Monte Carlo program various naming conventions have been used. These appendices attempt to provide a concise, useful guide linking conceptual variable to model variable to Monte Carlo variables designations. Tables give the basic characteristics of the output distributions for each of the 95 output VALs. These appendices describe in technical detail the Monte Carlo techniques used in the uncertainty analysis. The choice of Latin Hypercube sampling and the methodology employed to attribute output variability to input uncertainty is documented. A complete listing of the software and data base used to generate the Monte Carlo analysis is included.

  9. Study of a comet rendezvous mission. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Appendices to the comet Encke rendezvous mission consider relative positions of comet, earth and sun; viewing condition for Encke; detection of Taurid meteor streams; ephemeris of comet Encke; microwave and optical techniques in rendezvous mission; approach instruments; electrostatic equilibrium of ion engine spacecraft; comet flyby data for rendezvous spacecraft assembly; observations of P/Encke extracted from a compilation; and summary of technical innovations.

  10. 21 CFR Appendices C-F to Subpart B... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false C Appendices C-F to Subpart B of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT...

  11. 21 CFR Appendices C-F to Subpart B... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false C Appendices C-F to Subpart B of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT...

  12. 21 CFR Appendices C-F to Subpart B... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false C Appendices C-F to Subpart B of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT...

  13. 21 CFR Appendices C-F to Subpart B... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false C Appendices C-F to Subpart B of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT...

  14. Safety and Efficacy of Polymeric Clips for Appendiceal Stump Closure

    PubMed Central

    Tabone, Lawrence E.; Fong, Philip; Yoo, Jin S.; Park, Chan W.

    2016-01-01

    Background and Objectives: Laparoscopic appendectomy remains one of the most common emergency general surgical procedures in the United States. In an era of increasing focus on costs in medical care, we sought to evaluate the use of polymeric clips to secure the appendiceal base during laparoscopic appendectomy. Methods: We performed a prospective cohort study of patients undergoing laparoscopic appendectomy from April 2013 through September 2014 at a single academic teaching institution. Polymeric clips were used to secure the appendiceal stump. Tissue dissection techniques and control of the mesoappendix were the operating surgeon's choice. Clinical outcomes are reported. Results: A total of 25 patients (56% women; mean age, 41 y; body mass index of 29 kg/m2) were enrolled in our study and underwent laparoscopic appendectomy with polymeric clips. One patient was unable to have polymeric clips placed due to inflammation of the appendiceal base. There were no major perioperative complications. One patient developed a suture abscess in the umbilical incision, and another had prolonged ileus with computed tomography demonstrating persistent pelvic fluid that did not require intervention. Median length of stay was 1 d and mean length of follow-up was 81 d. The use of polymeric clips contributed ∼ $32 to the overall operative cost. Conclusions: Polymeric clips are a safe alternative for securing the appendiceal base in laparoscopic appendectomy. They offer significant cost savings without any evidence of increased complications. PMID:27493473

  15. Remote-handled transuranic system assessment appendices. Volume 2

    SciTech Connect

    1995-11-01

    Volume 2 of this report contains six appendices to the report: Inventory and generation of remote-handled transuranic waste; Remote-handled transuranic waste site storage; Characterization of remote-handled transuranic waste; RH-TRU waste treatment alternatives system analysis; Packaging and transportation study; and Remote-handled transuranic waste disposal alternatives.

  16. Report to Congress on the feasibility of establishing a heating oil component to the Strategic Petroleum Reserve. Volume 2: Appendices

    SciTech Connect

    1998-06-01

    Nine appendices to the main report are included in this volume. They are: Northeastern US distillate supply systems; New England fuel oil storage capacities and inventories; Characteristics of the northeast natural gas market; Documentation of statistical models and calculation of benefits; Regional product reserve study; Other countries` experience with refined product storage; Global refining supply demand appraisal; Summary of federal authorities relevant to the establishment of petroleum product reserves; Product stability and turnover requirements.

  17. Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis

    PubMed Central

    Millis, Sherri Z.; Kimbrough, Jeffery; Doll, Nancy; Von Hoff, Daniel; Ramanathan, Ramesh K.

    2017-01-01

    Background Appendiceal cancers are rare and consist of carcinoid, mucocele, pseudomyxoma peritonei (PMP), goblet cell carcinoma, lymphoma, and adenocarcinoma histologies. Current treatment involves surgical resection or debulking, but no standard exists for adjuvant chemotherapy or treatment for metastatic disease. Methods Samples were identified from approximately 60,000 global tumors analyzed at a referral molecular profiling CLIA-certified laboratory. A total of 588 samples with appendix primary tumor sites were identified (male/female ratio of 2:3; mean age =55). Sixty-two percent of samples were adenocarcinomas (used for analysis); the rest consisted of 9% goblet cell, 15% mucinous; 6% pseudomyxoma, and less than 5% carcinoids and 2% neuroendocrine. Tests included sequencing [Sanger, next generation sequencing (NGS)], protein expression/immunohistochemistry (IHC), and gene amplification [fluorescent in situ hybridization (FISH) or CISH]. Results Profiling across all appendiceal cancer histological subtypes for IHC revealed: 97% BRCP, 81% MRP1, 81% COX-2, 71% MGMT, 56% TOPO1, 5% PTEN, 52% EGFR, 40% ERCC1, 38% SPARC, 35% PDGFR, 35% TOPO2A, 25% RRM1, 21% TS, 16% cKIT, and 12% for TLE3. NGS revealed mutations in the following genes: 50.4% KRAS, 21.9% P53, 17.6% GNAS, 16.5% SMAD4, 10% APC, 7.5% ATM, 5.5% PIK3CA, 5.0% FBXW7, and 1.8% BRAF. Conclusions Appendiceal cancers show considerable heterogeneity with high levels of drug resistance proteins (BCRP and MRP1), which highlight the difficulty in treating these tumors and suggest an individualized approach to treatment. The incidence of low TS (79%) could be used as a backbone of therapy (using inhibitors such as 5FU/capecitabine or newer agents). Therapeutic options includeTOPO1 inhibitors (irinotecan/topotecan), EGFR inhibitors (erlotinib, cetuximab), PDGFR antagonists (regorafenib, axitinib), MGMT (temozolomide). Clinical trials targeting pathways involving KRAS, p53, GNAS, SMAD4, APC, ATM, PIK3CA, FBXW7, and

  18. Yakima River Spring Chinook Enhancement Study Appendices, 1991 Final Report.

    SciTech Connect

    Fast, David E.

    1991-05-01

    This document consists of the appendices for annual report DOE/BP/39461--9 which is summarized as follows. The population of Yakima River spring chinook salmon (Oncorhynchus tschawytscha) has been drastically reduced from historic levels reported to be as high as 250,000 adults (Smoker 1956). This reduction is the result of a series of problems including mainstem Columbia dams, dams within the Yakima itself, severely reduced flows due to irrigation diversions, outmigrant loss in irrigation canals, increased thermal and sediment loading, and overfishing. Despite these problems, the return of spring chinook to the Yakima River has continued at levels ranging from 854 to 9,442 adults since 1958. In October 1982, the Bonneville Power Administration contracted the Yakima Indian Nation to develop methods to increase production of spring chinook in the Yakima system. The Yakima Nation's current enhancement policy attempts to maintain the genetic integrity of the spring chinook stock native to the Yakima Basin. Relatively small numbers of hatchery fish have been released into the basin in past years. The goal of this study was to develop data that will be used to present management alternatives for Yakima River spring chinook. A major objective of this study is to determine the distribution, abundance and survival of wild Yakima River spring chinook. The second major objective of this study is to determine the relative effectiveness of different methods of hatchery supplementation. The last three major objectives of the study are to locate and define areas in the watershed that may be used for the rearing of spring chinook; to define strategies for enhancing natural production of spring chinook in the Yakima River; and to determine the physical and biological limitations on production within the system.

  19. Final report from VFL Technologies for the pilot-scale thermal treatment of Lower East Fork Poplar Creek floodplain soils. LEFPC appendices. Volume 5. Appendix V-D

    SciTech Connect

    1994-09-01

    This final report from VFL Technologies for the pilot-scale thermal treatment of lower East Fork Poplar Creek floodplain soils dated September 1994 contains LEFPC Appendices, Volume 5, Appendix V - D. This appendix includes the final verification run data package (PAH, TCLP herbicides, TCLP pesticides).

  20. A study of toxic emissions from a coal-fired power plant utilizing an ESP/wet FGD system. Final report, Volume 2 of 2 - appendices

    SciTech Connect

    Not Available

    1994-07-01

    This volume contains the appendices for a coal-fired power plant toxic emissions study. Included are Process data log sheets from Coal Creek, Auditing information, Sampling protocol, Field sampling data sheets, Quality assurance/quality control, Analytical protocol, and Uncertainty analyses.

  1. Environmental Impact Atatement for the new San Clemente Project, Monterey County, California - Regulatory Permit Application Number 16516s09. Appendices. Draft environmental impact report

    SciTech Connect

    Not Available

    1987-09-01

    This report consists of six Appendices. Topics include: Description of Carmel Valley simulation model; List of technical support documents; Avian survey and bird list; reptile and amphibian list; mammal list; plant list; riparian zone mitigation plan; State and federal air quality standards; Population and employment projections; Archaeological report.

  2. Groundwater Quality Assessment Plan: Dickson County Landfill, Dickson County, Tennessee, including Application for Authorization for Class V Underground Injection Well

    EPA Pesticide Factsheets

    Contains site investigation plan & data for assessment of groundwater quality at Dickson County Landfill, Dickson, Tennessee, with figures, tables, appendices, November 1994, including Application for Authorization for Class V Underground Injection Well.

  3. Mixing Dynamics of Supercritical Droplets and Jets (Revised To Include Appendices)

    DTIC Science & Technology

    2006-08-01

    al [26] explain that a cauliflower head contains branches or parts, which when removed and compared with the whole are very much the same, only...similar curve with the notion defined in relation to the cauliflower , there is a power law relation between the number of pieces, P, and the reduction...to a cauliflower , are self-similar only to within a narrow range of scales. Our objective here is to measure the fiactal dimension of the interface

  4. An economic assessment of STOL aircraft potential including terminal area environmental considerations. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Solomon, H. L.; Sokolsky, S.

    1973-01-01

    An economic assessment of short takeoff aircraft for short haul air transportation applications is presented. The economic viability and environmental compatibility of short takeoff aircraft service in high density areas were evaluated. The subjects discussed are: (1) aircraft configurations and performance, (2) airfield and terminal requirements, and (3) direct and indirect operating costs.

  5. Increasing resource allocation and research into tobacco control activities: a comprehensive approach including primary prevention, treatment and brief intervention.

    PubMed

    Richmond, R

    1993-01-01

    The range of tobacco control activities should be viewed as essential parts of a complex multi-component puzzle. Intervention strategies designed to address tobacco control should be comprehensive and include both primary and secondary prevention activities and be multi-faceted and capable of bringing about change at both the individual and broader social and cultural levels. In this paper I argue for a mutually inclusive framework in which the various components contribute in important and different ways. I examine the prevalence of smoking and identify the high risk groups, then I examine the range of available strategies and present the evidence for their success. I discuss the primary prevention approaches such as warning labels, taxes, price increases, workplace bans, education in schools, mass media and self-help materials, as well as brief interventions and treatment strategies which are conducted at the worksite, general practice and specialized cessation clinics. The areas for future research are delineated for increased resource allocation and include: the best ways to disseminate brief interventions to smokers, methods to motivate smokers; training of health professionals to deliver brief interventions; enhancing quitting and access to existing treatment resources among specific disadvantaged minority groups, e.g. migrants, unemployed youth, the effect on smoking prevalence of warning labels on cigarette packets and price rises on cigarettes.

  6. An Antimicrobial Metabolite from Bacillus sp.: Significant Activity Against Pathogenic Bacteria Including Multidrug-Resistant Clinical Strains

    PubMed Central

    Chalasani, Ajay G.; Dhanarajan, Gunaseelan; Nema, Sushma; Sen, Ramkrishna; Roy, Utpal

    2015-01-01

    In this study, the cell free modified tryptone soya broth (pH 7.4 ± 0.2) of Bacillus subtilis URID 12.1 showed significant antimicrobial activity against multidrug-resistant strains of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes and Enterococcus faecalis. The partially purified antimicrobial molecule was found to be resistant to extremes of pH and temperatures and also to higher concentrations of trypsin and proteinase K. The antimicrobial molecule was purified by a three-step method that included reversed-phase high performance liquid chromatography (RP-HPLC). The minimum inhibitory concentration (MIC) values were determined for 14 species of bacteria using a microbroth dilution technique. The HPLC-purified fraction showed the MICs ranging from 0.5 to 16 μg/ml for methicillin and vancomycin-resistant Staphylococcus aureus (MVRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains. The molecular mass of the antimicrobial compound was determined to be 842.37 Da. The same antimicrobial fraction showed negligible haemolytic activity against human red blood cells even at a concentration as high as 100 μg/ml. Because of its significant antimicrobial activity at low MIC values coupled with its non-haemolytic property, it may prove to be a novel antimicrobial lead molecule. PMID:26696963

  7. PITBUL: a physics-based modeling package for imaging and tracking of airborne targets for HEL applications including active illumination

    NASA Astrophysics Data System (ADS)

    Van Zandt, Noah R.; McCrae, Jack E.; Fiorino, Steven T.

    2013-05-01

    Aimpoint acquisition and maintenance is critical to high energy laser (HEL) system performance. This study demonstrates the development by the AFIT/CDE of a physics-based modeling package, PITBUL, for tracking airborne targets for HEL applications, including atmospheric and sensor effects and active illumination, which is a focus of this work. High-resolution simulated imagery of the 3D airborne target in-flight as seen from the laser position is generated using the HELSEEM model, and includes solar illumination, laser illumination, and thermal emission. Both CW and pulsed laser illumination are modeled, including the effects of illuminator scintillation, atmospheric backscatter, and speckle, which are treated at a first-principles level. Realistic vertical profiles of molecular and aerosol absorption and scattering, as well as optical turbulence, are generated using AFIT/CDE's Laser Environmental Effects Definition and Reference (LEEDR) model. The spatially and temporally varying effects of turbulence are calculated and applied via a fast-running wave optical method known as light tunneling. Sensor effects, for example blur, sampling, read-out noise, and random photon arrival, are applied to the imagery. Track algorithms, including centroid and Fitts correlation, as a part of a closed loop tracker are applied to the degraded imagery and scored, to provide an estimate of overall system performance. To gauge performance of a laser system against a UAV target, tracking results are presented as a function of signal to noise ratio. Additionally, validation efforts to date involving comparisons between simulated and experimental tracking of UAVs are presented.

  8. Diagnostic Dilemma in Appendiceal Mucormycosis: A Rare Case Report

    PubMed Central

    Prasad, Pande; Asha, George Mary; Mohan, Agarwal; Hitesh, Mehta

    2016-01-01

    Appendiceal mucormycosis is a rare life-threatening infection seen in immunocompromised patients. It is usually seen in chemotherapy induced neutropenia in patients with hematological malignancies. Clinically, the symptoms and signs may be masked due to ongoing corticosteroids. The condition may mimic bacterial appendicitis and the less serious condition, typhlitis. The disease demands prompt surgical debulking and aggressive antifungal treatment. However, surgery is delayed due to the poor performance status and severe neutropenia. This may lead to perforative peritonitis and further dissemination. The survival rates of such disease are dismal. Unfortunately, the diagnosis may be confirmed only on histological examination of the surgically excised tissue. Very few cases have been reported so far. We present here once such a fatal case of appendiceal mucormycosis in a 14-year-old boy who was immunosuppressed due to intensive induction therapy for Acute Myeloblastic Leukemia. PMID:27635276

  9. Appendiceal neuroendocrine tumors: Recent insights and clinical implications.

    PubMed

    Griniatsos, John; Michail, Othon

    2010-04-15

    New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. The clinical implication of that knowledge reflected to surgical strategies which also vary from simple appendicectomy to radical abdominal procedures based on specific clinical and histological characteristics. Since the diagnosis is usually established post-appendicectomy, current recommendations focus on the early detection of: (1) the subgroup of patients who require further therapy; (2) the recurrence based on the chromogranin a plasma levels; and (3) other malignancies which are commonly developed in patients with appendiceal NETs.

  10. Appendiceal neuroendocrine tumors: Recent insights and clinical implications

    PubMed Central

    Griniatsos, John; Michail, Othon

    2010-01-01

    New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. The clinical implication of that knowledge reflected to surgical strategies which also vary from simple appendicectomy to radical abdominal procedures based on specific clinical and histological characteristics. Since the diagnosis is usually established post-appendicectomy, current recommendations focus on the early detection of: (1) the subgroup of patients who require further therapy; (2) the recurrence based on the chromogranin a plasma levels; and (3) other malignancies which are commonly developed in patients with appendiceal NETs. PMID:21160597

  11. Waste Isolation Pilot Plant design validation: Final report, Appendices

    SciTech Connect

    Not Available

    1986-10-01

    This volume is comprised of the following appendices: DOE stipulated agreement with State of New Mexico (partial); geologic correlations; mathematical simulation of underground in situ behavior; C and SH shaft geologic logs and maps; waste shaft geologic logs and maps; exhaust shaft geologic log; test rooms geologic maps and sections; drift cross sections; facility level geologic core hole logs; geomechanical instrumentation data plots; and analytical data plots.

  12. Light Helicopter Family Trade-Off Analysis. Volume 8. Appendices S and T

    DTIC Science & Technology

    2014-01-02

    UNITED STATES AIMY MATERIEL COMMAND LIGHT I COPTER FAMlL Y TllADE-QFF ANALYSIS APPENDICES S AND T VOLUME VIII ACN : 69396 Copy IQJ. of 130...REPORT NUMBER ACN 69396 2. GOVT ACCESSION NO. 4. TITLE (and Subtltl») LIGHT HELICOPTER FAMILY TRADE-OFF ANALYSIS, APPENDICES S AND T, VOLUME VIII...UNITED STATES ARMY MATERIEL COMMAND LIGHT HELICOPTER FAMILY TRADE-OFF ANALYSIS APPENDICES S AND T . VOLUME VIII ACN : 69396 1 Accession For

  13. Central activation of the sympathetic nervous system including the adrenals in anaesthetized guinea pigs by the muscarinic agonist talsaclidine.

    PubMed

    Walland, A; Pieper, M P

    1998-04-01

    Talsaclidine, a novel M1-receptor selective muscarinic agonist for cholinergic substitution therapy of Alzheimer's disease, activates the sympathetic nervous system in guinea pigs and dogs at the orthosympathic ganglia and the paraganglionic adrenals. Results from guinea pigs provide indirect evidence for an additional central site of action. The present investigation in anaesthetized and vagotomized guinea pigs intended to demonstrate central activation of the sympathetic nervous system directly by comparing the blood pressure effects of intracerebroventricular and intravenous injections of small doses of talsaclidine. Increasing doses of 0.2 and 0.6 mg/kg talsaclidine were injected alternately into the third cerebral ventricle and intravenously in 6 guinea pigs before and after blockade of peripheral muscarinic receptors with 1 mg/kg ipratropium bromide i.v. In another group of 6 animals the injections were given into the cisterna cerebellomedullaris using the same protocol. In both groups central administration of talsaclidine caused dose-related hypertension while intravenous injections were hypotensive. Ipratropium bromide, a peripheral antimuscarinic drug, reversed this hypotensive action of intravenous talsaclidine into hypertension, but did not inhibit the effects of central administration. In contrast, atropine, an antimuscarinic drug which passes the blood-brain barrier, abolished the effect of 0.6 mg/kg talsaclidine injected into the cisterna cerebellomedullaris of 8 guinea pigs. The hypertensive effect of a first injection of 0.6 mg/kg talsaclidine into the cisterna cerebellomedullaris of 6 guinea pigs was approximately twice as large as that of a second given 90 min after bilateral adrenalectomy. Sham operation in another 6 animals was not inhibitory. The results demonstrate that talsaclidine, a selective muscarinic M1-receptor agonist, activates central parts of the sympathetic nervous system, including central projections of the adrenals by an action

  14. Type 4 appendiceal diverticulum within a de Garengeot hernia

    PubMed Central

    Coveney, E

    2016-01-01

    A de Garengeot hernia is defined as an incarcerated femoral hernia containing the vermiform appendix. We describe the case of a patient with a type 4 appendiceal diverticulum within a de Garengeot hernia and delineate valuable learning points. A 76-year-old woman presented with a 2-week history of a non-reducible painless femoral mass. Outpatient ultrasonography demonstrated a 36mm × 20mm smooth walled, multiloculated, partially cystic lesion anterior to the right inguinal ligament in keeping with an incarcerated femoral hernia. Intraoperatively, the appendix was found to be incarcerated in the sac of the femoral hernia and appendicectomy was performed. Histopathology demonstrated no evidence of inflammation in the appendix. However, an incidental appendiceal diverticulum was identified. It is widely recognised that a de Garengeot hernia may present with concomitant appendicitis, secondary to raised intraluminal pressure in the incarcerated appendix. Appendiceal diverticulosis is also believed to develop in response to raised pressure in the appendix and may therefore develop secondary to incarceration in a de Garengeot hernia. To our knowledge, only one such case has been described in the literature. A de Garengeot hernia is a rare entity, which poses significant diagnostic challenges. A high index of clinical suspicion is necessary as these hernias are at particularly high risk of perforation and so prompt surgical management is paramount. PMID:27269437

  15. Refinery siting workbook: appendices A and B

    SciTech Connect

    Not Available

    1980-07-01

    The objective of this effort is to develop and provide basic refinery-related information for use by state and local government officials as a basis for establishing responsible refinery siting requirements and policies consistent with the federal clean air and water standards and socio-economic concerns. The report will be organized into two volumes. The main text comprises the basic topics of physical concerns, regulatory requirements, and permitting activities, while the second volume includes the detailed appendix materials such as the applicable laws, and the necessary permits, as available and a glossary of pertinent terms. As a means to this objective, three refinery sizes, 200,000, 100,000 and 30,000 barrels per day crude charge will be discussed in technical terms. Process unit configuration will be presented which will maximize either gasoline or heating oil production with either sweet or sour crude oil feedstocks. The major issues affecting the socio-economic impact of siting the refinery in a given locale will be presented. These data will review the factors affecting the human environment and the issues that must be addressed to assess the impact that a refinery will have on a community. The key federal registrations which impact upon a refinery siting decision shall be reviewed. Summaries of these regulations and a simplified decision diagram for the air and water acts shall be presented to assist both government and refinery officials in understanding the scope of regulatory impact. All pertinent procedures required for refinery permitting shall be reviewed under the generalized headings of air, water, health and safety, land use, and miscellaneous permits. This categorization at the federal, state and local levels of government shall be used as a basis for establishing degrees of emphasis.

  16. Low-Grade Appendiceal Mucinous Neoplasm Presenting as an Adnexal Mass

    PubMed Central

    Panagopoulos, P.; Domi, V.; Christodoulaki, C.; Sioutis, D.; Papantoniou, N.

    2017-01-01

    Appendiceal tumors are rare, late diagnosed neoplasms that may not be differentiated from adnexal masses even by advanced imaging methods and other diagnostic procedures. They may be asymptomatic and remain undiagnosed until surgery. We report a case of an 80-year-old postmenopausal woman presenting with a pelvic mass and a history of weight loss. The patient underwent laparotomy which revealed an appendiceal mucocele, for which she received a full oncological procedure. The histology report showed a low-grade appendiceal mucinous neoplasm, and the patient underwent six cycles of chemotherapy. Appendiceal tumors should be kept in mind in patients with adnexal mass. PMID:28286683

  17. Activation of CpxRA in Haemophilus ducreyi primarily inhibits the expression of its targets, including major virulence determinants.

    PubMed

    Gangaiah, Dharanesh; Zhang, Xinjun; Fortney, Kate R; Baker, Beth; Liu, Yunlong; Munson, Robert S; Spinola, Stanley M

    2013-08-01

    Haemophilus ducreyi causes chancroid, a genital ulcer disease that facilitates the transmission of human immunodeficiency virus type 1. In humans, H. ducreyi is surrounded by phagocytes and must adapt to a hostile environment to survive. To sense and respond to environmental cues, bacteria frequently use two-component signal transduction (2CST) systems. The only obvious 2CST system in H. ducreyi is CpxRA; CpxR is a response regulator, and CpxA is a sensor kinase. Previous studies by Hansen and coworkers showed that CpxR directly represses the expression of dsrA, the lspB-lspA2 operon, and the flp operon, which are required for virulence in humans. They further showed that CpxA functions predominantly as a phosphatase in vitro to maintain the expression of virulence determinants. Since a cpxA mutant is avirulent while a cpxR mutant is fully virulent in humans, CpxA also likely functions predominantly as a phosphatase in vivo. To better understand the role of H. ducreyi CpxRA in controlling virulence determinants, here we defined genes potentially regulated by CpxRA by using RNA-Seq. Activation of CpxR by deletion of cpxA repressed nearly 70% of its targets, including seven established virulence determinants. Inactivation of CpxR by deletion of cpxR differentially regulated few genes and increased the expression of one virulence determinant. We identified a CpxR binding motif that was enriched in downregulated but not upregulated targets. These data reinforce the hypothesis that CpxA phosphatase activity plays a critical role in controlling H. ducreyi virulence in vivo. Characterization of the downregulated genes may offer new insights into pathogenesis.

  18. Survey of strong motion earthquake effects on thermal power plants in California with emphasis on piping systems. Volume 2, Appendices

    SciTech Connect

    Stevenson, J.D.

    1995-11-01

    Volume 2 of the ``Survey of Strong Motion Earthquake Effects on Thermal Power Plants in California with Emphasis on Piping Systems`` contains Appendices which detail the detail design and seismic response of several power plants subjected to strong motion earthquakes. The particular plants considered include the Ormond Beach, Long Beach and Seal Beach, Burbank, El Centro, Glendale, Humboldt Bay, Kem Valley, Pasadena and Valley power plants. Included is a typical power plant piping specification and photographs of typical power plant piping specification and photographs of typical piping and support installations for the plants surveyed. Detailed piping support spacing data are also included.

  19. Antimicrobial Active Packaging including Chitosan Films with Thymus vulgaris L. Essential Oil for Ready-to-Eat Meat.

    PubMed

    Quesada, Jesús; Sendra, Esther; Navarro, Casilda; Sayas-Barberá, Estrella

    2016-08-29

    An active packaging system has been designed for the shelf life extension of ready to eat meat products. The package included an inner surface coated with a chitosan film with thyme essential oil (0%, 0.5%, 1%, and 2%) not in direct contact with the meat. Our aim was to reduce the impact of thyme essential oil (EO) on meat sensory properties by using a chemotype with low odor intensity. The pH, color parameters, microbial populations, and sensory properties were assessed during 4 weeks of refrigerated storage. The presence of EO films reduced yeast populations, whereas aerobic mesophilic bacteria, lactic acid bacteria, and enterobacteria were not affected by the presence of the EO in the films. Meat color preservation (a *) was enhanced in the presence of EO, giving a better appearance to the packaged meat. The presence of the chitosan-EO layer reduced water condensation inside the package, whereas packages containing only chitosan had evident water droplets. Thyme odor was perceived as desirable in cooked meat, and the typical product odor intensity decreased by increasing the EO concentration. Further studies should point towards developing oil blends or combinations with natural antimicrobial agents to be incorporated into the film to improve its antimicrobial properties.

  20. Antimicrobial Active Packaging including Chitosan Films with Thymus vulgaris L. Essential Oil for Ready-to-Eat Meat

    PubMed Central

    Quesada, Jesús; Sendra, Esther; Navarro, Casilda; Sayas-Barberá, Estrella

    2016-01-01

    An active packaging system has been designed for the shelf life extension of ready to eat meat products. The package included an inner surface coated with a chitosan film with thyme essential oil (0%, 0.5%, 1%, and 2%) not in direct contact with the meat. Our aim was to reduce the impact of thyme essential oil (EO) on meat sensory properties by using a chemotype with low odor intensity. The pH, color parameters, microbial populations, and sensory properties were assessed during 4 weeks of refrigerated storage. The presence of EO films reduced yeast populations, whereas aerobic mesophilic bacteria, lactic acid bacteria, and enterobacteria were not affected by the presence of the EO in the films. Meat color preservation (a *) was enhanced in the presence of EO, giving a better appearance to the packaged meat. The presence of the chitosan-EO layer reduced water condensation inside the package, whereas packages containing only chitosan had evident water droplets. Thyme odor was perceived as desirable in cooked meat, and the typical product odor intensity decreased by increasing the EO concentration. Further studies should point towards developing oil blends or combinations with natural antimicrobial agents to be incorporated into the film to improve its antimicrobial properties. PMID:28231152

  1. Refinery siting workbook: appendices C to O

    SciTech Connect

    Not Available

    1980-07-01

    Applicable laws and permits available for the selection and building of petroleum refineries are enclosed. A glossary of pertinent terms is also included. References related to the National Environmental Policy Act, the Clean Air Act, the Federal Water Pollution Control Act, Resource Conservation and Recovery Act, Toxic Substance Control Act, and Wetlands and Coastal Zone are included. Permit information is also presented. (DC)

  2. RMP Guidance for Offsite Consequence Analysis - Appendices

    EPA Pesticide Factsheets

    Assists owners/operators of processes covered by Chemical Accident Prevention Program rule in analysis of offsite consequences for toxic or flammable substances. Includes methods and tables for calculating worst-case/alternative scenarios and endpoints.

  3. Advanced vehicle systems assessment. Volume 5: Appendices

    NASA Technical Reports Server (NTRS)

    Hardy, K.

    1985-01-01

    An appendix to the systems assessment for the electric hybrid vehicle project is presented. Included are battery design, battery cost, aluminum vehicle construction, IBM PC computer programs and battery discharge models.

  4. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

    PubMed

    Pfäffle, Heike N; Wang, Meng; Gheorghiu, Liliana; Ferraiolo, Natalie; Greninger, Patricia; Borgmann, Kerstin; Settleman, Jeffrey; Benes, Cyril H; Sequist, Lecia V; Zou, Lee; Willers, Henning

    2013-10-15

    In patients with lung cancer whose tumors harbor activating mutations in the EGF receptor (EGFR), increased responses to platinum-based chemotherapies are seen compared with wild-type cancers. However, the mechanisms underlying this association have remained elusive. Here, we describe a cellular phenotype of cross-linker sensitivity in a subset of EGFR-mutant lung cancer cell lines that is reminiscent of the defects seen in cells impaired in the Fanconi anemia pathway, including a pronounced G2-M cell-cycle arrest and chromosomal radial formation. We identified a defect downstream of FANCD2 at the level of recruitment of FAN1 nuclease and DNA interstrand cross-link (ICL) unhooking. The effect of EGFR mutation was epistatic with FANCD2. Consistent with the known role of FANCD2 in promoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells also exhibited an impaired RAD51 foci response to ICLs, but not to DNA double-strand breaks. EGFR kinase inhibition affected RAD51 foci formation neither in EGFR-mutant nor wild-type cells. In contrast, EGFR depletion or overexpression of mutant EGFR in wild-type cells suppressed RAD51 foci, suggesting an EGFR kinase-independent regulation of DNA repair. Interestingly, EGFR-mutant cells treated with the PARP inhibitor olaparib also displayed decreased FAN1 foci induction, coupled with a putative block in a late HRR step. As a result, EGFR-mutant lung cancer cells exhibited olaparib sensitivity in vitro and in vivo. Our findings provide insight into the mechanisms of cisplatin and PARP inhibitor sensitivity of EGFR-mutant cells, yielding potential therapeutic opportunities for further treatment individualization in this genetically defined subset of lung cancer.

  5. PRiorities In School Mathematics. Final Report on Data from the PRISM Project. Appendices C and D.

    ERIC Educational Resources Information Center

    Osborne, Alan R.; And Others

    These two appendices contain item-by-item data from two rounds of national surveys designed to determine preferences and priorities for school mathematics in the 1980's. Appendix C contains data from the first-round preference survey. Appendix D contains the data from the second-round priority survey. The body of the report plus Appendices A and…

  6. 7 CFR Appendices 1, 2 and 3 to... - Dairy Tariff-Rate Import Quota Licensing

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Dairy Tariff-Rate Import Quota Licensing 1, Appendices... Dairy Tariff-Rate Import Quota Licensing Supersedure of Import Regulation 1, Revision 7. Appendices 1, 2 and 3 to Subpart—Dairy Tariff-Rate Import Quota Licensing Articles Subject to: Appendix 1,...

  7. [Giant appendiceal mucocele during laparotomy for acute abdomen. Report of a case and brief review].

    PubMed

    Caiazzo, P; Comentale, A; Rampone, B; Di Lascio, P; Morlino, A; Pastore, M; Del Vecchio, G; Tramutoli, P R

    2010-01-01

    The authors describe a case of giant appendiceal mucocele, secondary to a mucinous neoplasm of the appendix, diagnosed during laparotomy for acute abdomen. By a review of the literature they stress the rarity of this lesion, the particular onset in their case as acute complication of appendiceal neoplasm with rupture of the intestinal wall, the difficulties of diagnosis and management in emergency.

  8. HEPS Inventory Tool: An Inventory Tool Including Quality Assessment of School Interventions on Healthy Eating and Physical Activity

    ERIC Educational Resources Information Center

    Dadaczynski, Kevin; Paulus, Peter; de Vries, Nanne; de Ruiter, Silvia; Buijs, Goof

    2010-01-01

    The HEPS Inventory Tool aims to support stakeholders working in school health promotion to promote high quality interventions on healthy eating and physical activity. As a tool it provides a step-by-step approach on how to develop a national or regional inventory of existing school based interventions on healthy eating and physical activity. It…

  9. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  10. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  11. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  12. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  13. 14 CFR 440.11 - Duration of coverage for licensed launch, including suborbital launch, or permitted activities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... LICENSING FINANCIAL RESPONSIBILITY Financial Responsibility for Licensed and Permitted Activities § 440.11...; modifications. (a) Insurance coverage required under § 440.9, or other form of financial responsibility, shall... licensed launch or permitted activities is sufficiently small that financial responsibility is no...

  14. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  15. Incidence and structure of the appendices of the testis and epididymis.

    PubMed Central

    Sahni, D; Jit, I; Joshi, K; Sanjeev

    1996-01-01

    In paired tests obtained from 425 adults, 50 children and 10 neonates, the incidence of testicular appendices was 76% in adults (93.3% sessile) and 83.3% in neonates/children (88% sessile). An epididymal appendix was present in 21.9% of adults and 20% of neonates/children, out of which 79% were stalked in both types of specimen. Three sessile testicular appendices and 11 epididymal appendices were double. The microscopic structure of the appendices and the ultrastructure of their epithelia are described. Testicular or epididymal appendices were not present in any domestic or laboratory animal examined except the horse. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 PMID:8886956

  16. Endovascular Repair of a Secondary Aorto-Appendiceal Fistula

    SciTech Connect

    Tse, Donald M. L.; Thompson, Andrew R. A.; Perkins, Jeremy; Bratby, Mark J.; Anthony, Susan; Uberoi, Raman

    2011-10-15

    Aortoenteric fistula (AEF) is an uncommon but serious complication occurring after aortic surgery and may occur at any site in the gastrointestinal tract, with the duodenum being the most common. Conventional surgical repair of secondary AEF has high mortality, whereas endovascular repair has emerged as an alternative treatment despite concerns about persistent or recurrent infection. We report the case of a 91-year old man who was admitted with rectal bleeding from an aorto-appendiceal fistula 9 years after open abdominal aortic aneurysm repair. This rare site for AEF was diagnosed on computed tomography, and we present the first case of endovascular treatment of this uncommon complication.

  17. The economic impact of NASA R and D spending Appendices

    NASA Technical Reports Server (NTRS)

    Evans, M. K.

    1976-01-01

    Seven appendices related to a previous report on the economic impact of NASA R and D spending were presented. They dealt with: (1) theoretical and empirical development of aggregate production functions, (2) the calculation of the time series for the rate of technological progress, (3) the calculation of the industry mix variable, (4) the estimation of distributed lags, (5) the estimation of the equations for gamma, (6) a ten-year forecast of the U.S. economy, (7) simulations of the macroeconomic model for increases in NASA R and D spending of $1.0, $.0.5, and 0.1 billions.

  18. Measurement of Lake Roosevelt Biota in Relation to Reservoir Operations Appendices; 1991 Annual Report.

    SciTech Connect

    Griffith, Janelle R.; McDowell, Amy C.; Scholz, Allan T.

    1995-08-01

    This report consists of appendices A-F containing the biological data which were collected from Lake Roosevelt, Washington. The data are to be used in the design of a computer model that would predict biological responses of reservoir operations as part of the System Operation Review program. Major components of the model included: Quantification of impacts to phytoplankton, zooplanktons, benthic invertebrates, and fish caused by reservoir drawdowns and low water retention times; quantification of number, distribution, and use of fish food organisms in the reservoir by season; determination of seasonal growth of fish species as related to reservoir operations, prey abundance and utilization; and quantification of entrainment levels of zooplankton and fish as related to reservoir operations and water retention times.

  19. Saint Lawrence Seaway Additional Locks Study. Appendices.

    DTIC Science & Technology

    1982-07-01

    developed, or which had been given a high priority use for I r environmental protection by the New York State Office of Planning Services. It did...snowmobiles.) Recreational problems include land-use competition, high acquisition costs for lands, public opposition and legal restraints on...receipts at the new Port Authority terminal was initiated in 1974 upon completion of a pipeline and this traffic currently represents a high percent of

  20. Low Intensity Conflict. Volume 2. Appendices.

    DTIC Science & Technology

    1983-06-30

    parapsychology, which includes extrasensory perception (ESP). U.S. intelligence agencies, according to NBC Inc., have not taken the Soviet effort too seriously...theoreti- cal adjustment. What remains important is the perceptions of those involved concerning the implications of winning or losing. Perceotions are...opponents feel about such matters is of great concern. In 1948, over 100,000 British security forces withdrew from Palestine because of perceptions of

  1. Synthetic Vision Technology Demonstration. Volume 4. Appendices

    DTIC Science & Technology

    1993-12-01

    Aeronautics Walter F. Home, GTRI 1 Richard F. Tucker, TRW B. Hudson, GTRI Synthetic Vision Program Office Federal Aviation Administration December 1993 A...Avionics Trevor Bushell (213) 305-8376 Eastman Kodak Company Raymond Rehberg (716) 253-2261 Georgia Tech Research Institute Walter Home (404) 528-7874...Aircraft Attitude In Euler angles (pitch, roll, yaw). B. Position with respect to runway scene C. Atitiude relative to runway scene; including

  2. Flight program language requirements. Volume 3: Appendices

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Government-sponsored study and development efforts were directed toward design and implementation of high level programming languages suitable for future aerospace applications. The study centered around an evaluation of the four most pertinent existing aerospace languages. Evaluation criteria were established, and selected kernels from the current Saturn 5 and Skylab flight programs were used as benchmark problems for sample coding. An independent review of the language specifications incorporated anticipated future programming requirements into the evaluation. A set of language requirements was synthesized from these activities.

  3. Foothills Parkway Section 8B Final Environmental Report, Volume 5, Appendices J-M

    SciTech Connect

    Blasing, T.J.; Cada, G.F.; Carer, M.; Chin, S.M.; Dickerman, J.A.; Etnier, D.A.; Gibson, R.; Harvey, M.; Hatcher, B.; Lietzske, D.; Mann, L.K.; Mulholland, P.J.; Petrich, C.H.; Pounds, L.; Ranney, J.; Reed, R.M.; Ryan, P.F.; Schweitzer, M.; Smith, D.; Thomason, P.; Wade, M.C.

    1999-07-01

    In 1994, Oak Ridge National Laboratory (ORNL) was tasked by the National Park Service (NPS) to prepare an Environmental Report (ER) for Section 8B of the Foothills Parkway in the Great Smoky Mountains National Park (GSMNP). Section 8B represents 27.7 km (14.2 miles) of a total of 115 km (72 miles) of the planned Foothills Parkway and would connect the Cosby community on the east to the incorporated town of Pittman Center to the west. The major deliverables for the project are listed. From August 1995 through October 1996, NPS, GSMNP, and ORNL staff interacted with Federal Highway Administration staff to develop a conceptual design plan for Section 8B with the intent of protecting critical resources identified during the ER process to the extent possible. In addition, ORNL arranged for bioengineering experts to discuss techniques that might be employed on Section 8B with NPS, GSMNP, and ORNL staff during September 1996. For the purposes of this ER, there are two basic alternatives under consideration: (1) a build alternative and (2) a no-build alternative. Within the build alternative are a number of options including constructing Section 8B with no interchanges, constructing Section 8B with an interchange at SR 416 or U.S. 321, constructing Section 8B with a spur road on Webb Mountain, and considering operation of Section 8B both before and after the operation of Section 8C. The no-build alternative is considered the no-action alternative and is not to construct Section 8B. This volume of the ER consists of Appendices J through M, which describe potential impacts regarding traffic, noise, and aesthetics. The results of the traffic studies described in these appendices resulted in the following conclusions: Unacceptable levels of service will occur on numerous roads within and outside of the park increasingly in the Mure based upon current and future regional growth. However, the results of the traffic assessment indicated that there would be no significant or

  4. International photovoltaic program. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Costello, D.; Koontz, R.; Posner, D.; Heiferling, P.; Carpenter, P.; Forman, S.; Perelman, L.

    1979-01-01

    The results of analyses conducted in preparation of an international photovoltaic marketing plan are summarized. Included are compilations of relevant statutes and existing Federal programs; strategies designed to expand the use of photovoltaics abroad; information on the domestic photovoltaic plan and its impact on the proposed international plan; perspectives on foreign competition; industry views on the international photovoltaic market and ideas about the how US government actions could affect this market;international financing issues; and information on issues affecting foreign policy and developing countries.

  5. Etiology and Progression of Acute Muscle Tension Related Low Back Pain Occurring During Sustained Activity Including Combat Training Exercises

    DTIC Science & Technology

    1992-01-31

    myelogram consistent with HNP. b. DEGENERATIVE ARTHROSIS , SPONDYLOLYSIS, SPONDYLOLISTHESIS: (1) Radiographic findings consistent with spondylolysis...spondylolisthesis, or degenerative arthritis. This would include facet arthrosis , oseteophyte formation, disc space narrowing, anterior/posterior

  6. Appendices B thru F, volume 3

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The purpose of this investigation was to determine if the intermodule ventilation (IMV) systems and water distribution systems of Space Station Freedom (SSF) modules and nodes should be connected as they are interfaced with those already in operation. It was concluded that the AC configuration and attached LAB and HAB modules and nodes should be interconnected. The H2O circuits should also be interconnected. Interconnecting the air and water provides flexibility of operation and safety comparable to the Assembly Complete (AC) configuration. This requires only only that valves and ducts be provided in the AC nodes. The AC node interfaces should also be scarred to provide for water transfer across these interfaces. Penalties for not connecting the Intermodular Ventilation (IMV) system and water circuits include an additional AR unit, possible increased water storage requirements, and considerable reduction in crew flexibility.

  7. Development of accelerated fuel-engines qualification procedures methodology. Volume II. Appendices. Interim report for Oct 80-Sep 81

    SciTech Connect

    Russell, J.A.; Cuellar, J.P. Jr; Tyler, J.C.; Erwin, J.; Knutson, W.K.

    1981-12-01

    This volume of appendices includes: AVRADCOM Aircraft/Engine Component Listings; AFLRL Elastomer Swell and Hardness Data; AFLRL Elastomer Retention Properties; JFC 78 500-Hour Shale Oil Fuel Plan of Test, April 20, 1981; JFC 78 Shale Oil Fuel Plan of Test, Revised July 30, 1981; Pre and Post Test Definition Data; Spot Calibration; Flow Test; Fuel Characteristics and Lubricity and Interfacial Tension; Detailed Component Test Results; Disassembly and Inspection Results; Identification of Critical Fuel System Components; Existing Engine Qualifications Procedures; NATO Standard Engine Laboratory Test-Edition June 80; Fuel System Components Qualification Procedures; and EPA Heavy-Duty Diesel Engine Exhaust Emissions Certification and Test Procedures.

  8. Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis

    PubMed Central

    Tiruveedhula, V.V.N. Phani Babu; Witzigmann, Christopher M.; Verma, Ranjit; Kabir, M. Shahjahan; Rott, Marc; Schwan, William R.; Medina-Bielski, Sara; Lane, Michelle; Close, William; Polanowski, Rebecca L.; Sherman, David; Monte, Aaron; Deschamps, Jeffrey R.; Cook, James M.

    2013-01-01

    The alarming increase in bacterial resistance over the last decade along with a dramatic decrease in new treatments for infections has led to problems in the healthcare industry. Tuberculosis (TB) is caused mainly by Mycobacterium tuberculosis which is responsible for 1.4 million deaths per year. A world-wide threat with HIV co-infected with multi and extensively drug-resistant strains of TB has emerged. In this regard, herein, novel acrylic acid ethyl ester derivatives were synthesized in simple, efficient routes and evaluated as potential agents against several Mycobacterium species. These were synthesized via a stereospecific process for structure activity relationship (SAR) studies. Minimum inhibitory concentration (MIC) assays indicated that esters 12, 13, and 20 exhibited greater in vitro activity against Mycobacterium smegmatis than rifampin, one of the current, first-line anti-mycobacterial chemotherapeutic agents. Based on these studies the acrylic ester 20 has been developed as a potential lead compound which was found to have an MIC value of 0.4 μg/mL against Mycobacterium tuberculosis. The SAR and biological activity of this series is presented; a Michael – acceptor mechanism appears to be important for potent activity of this series of analogs. PMID:24200931

  9. Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides.

    PubMed

    Romanova, Elena V; McKay, Natasha; Weiss, Klaudiusz R; Sweedler, Jonathan V; Koester, John

    2007-01-01

    Splice-variant products of the R15 neuropeptide gene are differentially expressed within the CNS of Aplysia. The goal of this study was to test whether the neurons in the abdominal ganglion that express the peptides encoded by this gene are part of a common circuit. Expression of R15 peptides had been demonstrated previously in neuron R15. Using a combination of immunocytochemical and analytical methods, this study demonstrated that R15 peptides are also expressed in heart exciter neuron RB(HE), the two L9(G) gill motoneurons, and L40--a newly identified interneuron. Mass spectrometric profiling of individual neurons that exhibit R15 peptide-like immunoreactivity confirmed the mutually exclusive expression of two splice-variant forms of R15 peptides in different neurons. The L9(G) cells were found to co-express pedal peptide in addition to the R15 peptides. The R15 peptide-expressing neurons examined here were shown to be part of an autonomic control circuit that is active during fictive locomotion. Activity in this circuit contributes to implementing a central command that may help to coordinate autonomic activity with escape locomotion. Chronic extracellular nerve recording was used to determine the activity patterns of a subset of neurons of this circuit in vivo. These results demonstrate the potential utility of using shared patterns of neuropeptide expression as a guide for neural circuit identification.

  10. Prognostic features of 51 colorectal and 130 appendiceal cancer patients with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy.

    PubMed Central

    Sugarbaker, P H; Jablonski, K A

    1995-01-01

    OBJECTIVE: A treatment plan to be used in patients with peritoneal carcinomatosis was devised and tested as a Phase II study. BACKGROUND: Peritoneal carcinomatosis from appendical or colorectal cancer has been regarded as a fatal clinical entity. Treatment protocols have not been reported previously. METHODS: The authors used cytoreductive surgery and intraperitoneal chemotherapy to treat 181 consecutive patients with peritoneal carcinomatosis. There were 51 patients with colorectal cancer and 130 patients with appendiceal cancer. Mean follow-up is 24 months, with a range of 0 to 149 months. RESULTS: Clinical features that showed prognostic significance included appendiceal versus colorectal primary tumors (p = 0.0001), grade 1 versus grades 2 and 3 histopathology (p = 0.0003), complete versus incomplete cytoreductions (p = 0.0001), lymph node-negative versus lymph node-positive primary tumors (p = 0.0001), and volume of peritoneal carcinomatosis present preoperatively for colon cancer (p = 0.0006). Features with no statistical prognostic significance included preoperative tumor volume for appendiceal cancer, age, sex, number of cycles of chemotherapy, operative time, complications, blood loss, and institution providing treatment. From these prognostic features, four prognostic groups were identified, and 3-year survival was estimated by the product-limit survival method. Group I patients (n = 76) were those with grade 1 histology, no lymph node metastases, and complete cytoreductions (survival at 3 years = 99%). Group II patients (n = 23) were those with grade 2 or 3 histology, no lymph node metastases, and complete cytoreductions (65%). Group III patients (n = 24) had any histology, lymph node metastases, and complete cytoreductions (66%). Group IV patients (n = 58) had incomplete cytoreductions (20%). PMID:7857141

  11. An Intramolecular Silylene Borane Capable of Facile Activation of Small Molecules, Including Metal-Free Dehydrogenation of Water.

    PubMed

    Mo, Zhenbo; Szilvási, Tibor; Zhou, Yu-Peng; Yao, Shenglai; Driess, Matthias

    2017-02-27

    The first single-component N-heterocyclic silylene borane 1 (LSi-R-BMes2 ; L=PhC(N(t) Bu)2 ; R=1,12-xanthendiyl spacer; Mes=2,4,6-Me3 C6 H2 ), acting as a frustrated Lewis pair (FLP) in small-molecule activation, can be synthesized in 65 % yields. Its HOMO is largely localized at the silicon(II) atom and the LUMO has mainly boron 2p character. In small-molecule activation 1 allows access to the intramolecular silanone-borane 3 featuring a Si=O→B interaction through reaction with O2 , N2 O, or CO2 , and formation of silanethione borane 4 from reaction with S8 . The Si(II) center in 1 undergoes immediate hydrogenation if exposed to H2 at 1 atm pressure in benzene, affording the silane borane 5-H2 , L(H2 )Si-R-BMes2 . Remarkably, no H2 activation occurs if the single silylene LSiPh and Mes3 B intermolecularly separated are exposed to dihydrogen. Unexpectedly, the pre-organized Si-B separation in 1 enables a metal-free dehydrogenation of H2 O to give the silanone-borane 3 as reactive intermediate.

  12. Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress.

    PubMed

    Morita, Reiko; Yafune, Atsunori; Shiraki, Ayako; Itahashi, Megu; Ishii, Yuji; Akane, Hirotoshi; Nakane, Fumiyuki; Suzuki, Kazuhiko; Shibutani, Makoto; Mitsumori, Kunitoshi

    2013-01-01

    Orphenadrine (ORPH), an anticholinergic agent, is a cytochrome P450 (CYP) 2B inducer. CYP2B inducers are known to have liver tumor-promoting effects in rats. In this study, we performed a rat two-stage liver carcinogenesis bioassay to examine the tumor-promoting effect of ORPH and to clarify its possible mechanism of action. Male rats were given a single intraperitoneal injection of N-diethylnitrosamine (DEN) as an initiation treatment. Two weeks after DEN administration, rats were fed a diet containing ORPH (0, 750, or 1,500 ppm) for 6 weeks. One week after the ORPH-administration rats were subjected to two-thirds partial hepatectomy for the acceleration of hepatocellular proliferation. The number and area of glutathione S-transferase placental form-positive foci significantly increased in the DEN-ORPH groups. Real-time RT-PCR revealed increased mRNA expression levels of Cyp2b1/2, Mrp2 and Cyclin D1 in the DEN-ORPH groups and of Gpx2 and Gstm3 in the DEN-High ORPH group. Microsomal reactive oxygen species (ROS) production and oxidative stress markers such as thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine were increased in the DEN-High ORPH group. Immunohistochemically, constitutively active/androstane receptor (CAR) were clearly localized in the nuclei of hepatocytes in the DEN-ORPH groups. These results suggest that ORPH causes nuclear translocation of CAR resulting in the induction of the liver tumor-promoting activity. Furthermore, oxidative stress resulting from ROS production is also involved in the liver tumor-promoting activity of ORPH.

  13. Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine.

    PubMed

    Theys, K; Camacho, R J; Gomes, P; Vandamme, A M; Rhee, S Y

    2015-06-01

    Rilpivirine is a second-generation nonnucleoside reverse-transcriptase inhibitor (NNRTI) currently indicated for first-line therapy, but its clinical benefit for HIV-1 infected patients failing first-generation NNRTIs is largely undefined. This study quantified the extent of genotypic rilpivirine resistance in viral isolates from 1212 patients upon failure of efavirenz- or nevirapine-containing antiretroviral treatment, of whom more than respectively 80% and 90% showed high-level genotypic resistance to the failing NNRTI. Of all study patients, 47% showed a rilpivirine resistance-associated mutation (RPV-RAM), whereas preserved residual rilpivirine activity was predicted in half of the patients by three genotypic drug resistance interpretation algorithms. An NNRTI-dependent impact on rilpivirine resistance was detected. Compared with the use of nevirapine, the use of efavirenz was associated with a 32% lower risk of having a RPV-RAM and a 50% lower risk of predicted reduced rilpivirine susceptibility. Most prevalent RPV-RAMs after nevirapine experience were Y181C and H221Y, whereas L100I+K103N, Y188L and K101E occurred most in efavirenz-experienced patients. Predicted rilpivirine activity was not affected by HIV-1 subtype, although frequency of individual mutations differed across subtypes. In conclusion, this genotypic resistance analysis strongly suggests that the latest NNRTI, rilpivirine, may retain activity in a large proportion of HIV-1 patients in whom resistance failed while they were on an efavirenz- or nevirapine-containing regimen, and may present an attractive option for second-line treatment given its good safety profile and dosing convenience. However, prospective clinical studies assessing the effectiveness of rilpivirine for NNRTI-experienced patients are warranted to validate knowledge derived from genotypic and phenotypic drug resistance studies.

  14. 50 CFR 15.52 - Species included in the prohibited list. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Species included in the prohibited list... WILDLIFE AND PLANTS WILD BIRD CONSERVATION ACT List of Prohibited Species Not Listed in the Appendices to the Convention § 15.52 Species included in the prohibited list....

  15. 50 CFR 15.51 - Criteria for including species and countries in the prohibited list. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Criteria for including species and..., EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS WILD BIRD CONSERVATION ACT List of Prohibited Species Not Listed in the Appendices to the Convention § 15.51 Criteria for including species and countries in...

  16. 50 CFR 15.53 - Countries of export included in the prohibited list. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Countries of export included in the..., DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND... Appendices to the Convention § 15.53 Countries of export included in the prohibited list....

  17. The Influence of Organized Physical Activity (Including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed

    Bernardoni, Brittney; Scerpella, Tamara A; Rosenbaum, Paula F; Kanaley, Jill A; Raab, Lindsay N; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N

    2015-05-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semiannual records of anthropometry, maturity, and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year premenarche [predictor] and ~5 years postmenarche [dependent variable]). Regression analysis evaluated total adolescent interscan PA and PA over 3 maturity subphases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry, and strength indices at nondominant distal radius and femoral neck; 2) subhead BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or postmenarche), baseline bone status, adult body size and interscan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p > .07). Premenarcheal bone traits were strong predictors of most adult outcomes (semipartial r2 = .21-0.59, p ≤ .001). Adult 1/3 radius and subhead BMC were predicted by both total PA and PA 1-3 years postmenarche (p < .03). PA 3-5 years postmenarche predicted femoral narrow neck width, endosteal diameter, and buckling ratio (p < .05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females.

  18. The Influence of Organized Physical Activity (including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed Central

    Bernardoni, Brittney; Scerpella, Tamara A.; Rosenbaum, Paula F.; Kanaley, Jill A.; Raab, Lindsay N.; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N.

    2015-01-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semi-annual records of anthropometry, maturity and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year pre-menarche [predictor] and ~5 years post-menarche [dependent variable]). Regression analysis evaluated total adolescent inter-scan PA and PA over 3 maturity sub-phases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry and strength indices at non-dominant distal radius and femoral neck; 2) sub-head BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or post-menarche), baseline bone status, adult body size and inter-scan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p<0.07). Pre-menarcheal bone traits were strong predictors of most adult outcomes (semi-partial r2 = 0.21-0.59, p≤0.001). Adult 1/3 radius and sub-head BMC were predicted by both total PA and PA 1-3 years post-menarche (p<0.03). PA 3-5 years post-menarche predicted femoral narrow neck width, endosteal diameter and buckling ratio (p<0.05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females. PMID:25386845

  19. New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

    PubMed

    La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

    2014-08-14

    We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro the Hedgehog signaling pathway, strongly reducing luciferase activity in SAG treated NIH3T3 Shh-Light II cells, and inhibited the growth of medulloblastoma D283 cells at nanomolar concentrations. ARAPs 22 and 27 represent a new potent class of tubulin polymerization and cancer cell growth inhibitors with the potential to inhibit the Hedgehog signaling pathway.

  20. New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

    PubMed Central

    La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

    2014-01-01

    We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro the Hedgehog signaling pathway, strongly reducing luciferase activity in SAG treated NIH3T3 Shh-Light II cells, and inhibited the growth of medulloblastoma D283 cells at nanomolar concentrations. ARAPs 22 and 27 represent a new potent class of tubulin polymerization and cancer cell growth inhibitors with the potential to inhibit the Hedgehog signaling pathway. PMID:25025991

  1. Identification of a gene for pyruvate-insensitive mitochondrial alternative oxidase expressed in the thermogenic appendices in Arum maculatum.

    PubMed

    Ito, Kikukatsu; Ogata, Takafumi; Kakizaki, Yusuke; Elliott, Catherine; Albury, Mary S; Moore, Anthony L

    2011-12-01

    Heat production in thermogenic plants has been attributed to a large increase in the expression of the alternative oxidase (AOX). AOX acts as an alternative terminal oxidase in the mitochondrial respiratory chain, where it reduces molecular oxygen to water. In contrast to the mitochondrial terminal oxidase, cytochrome c oxidase, AOX is nonprotonmotive and thus allows the dramatic drop in free energy between ubiquinol and oxygen to be dissipated as heat. Using reverse transcription-polymerase chain reaction-based cloning, we reveal that, although at least seven cDNAs for AOX exist (AmAOX1a, -1b, -1c, -1d, -1e, -1f, and -1g) in Arum maculatum, the organ and developmental regulation for each is distinct. In particular, the expression of AmAOX1e transcripts appears to predominate in thermogenic appendices among the seven AmAOXs. Interestingly, the amino acid sequence of AmAOX1e indicates that the ENV element found in almost all other AOX sequences, including AmAOX1a, -1b, -1c, -1d, and -1f, is substituted by QNT. The existence of a QNT motif in AmAOX1e was confirmed by nano-liquid chromatography-tandem mass spectrometry analysis of mitochondrial proteins from thermogenic appendices. Further functional analyses with mitochondria prepared using a yeast heterologous expression system demonstrated that AmAOX1e is insensitive to stimulation by pyruvate. These data suggest that a QNT type of pyruvate-insensitive AOX, AmAOX1e, plays a crucial role in stage- and organ-specific heat production in the appendices of A. maculatum.

  2. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.

  3. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Text, Appendices A--C. Final report

    SciTech Connect

    1988-07-01

    This Remedial Action Plan (RAP) has been developed to serve a two- fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Appendices A,B, and C are provided as part of this document. Appendix A presents regulatory compliance issues, Appendix B provides details of the engineering design, and Appendix C presents the radiological support plan.

  4. A comparison of methods of assessment of body composition including neutron activation analysis of total body nitrogen.

    PubMed

    Lukaski, H C; Mendez, J; Buskirk, E R; Cohn, S H

    1981-08-01

    Fourteen healthy men underwent determinations of total body nitrogen (TBN) by prompt gamma neutron activation analysis and total body potassium (TBK) by whole body counting to estimate the muscle and nonmuscle components of the fat-free body mass (FFBM) and their protein contents. Comparison of FFBM estimated from TBN and TBK (60.6 +/- 6.9 kg, mean +/- SD), densitometry (62.3 +/- 7.1 kg), TBK alone (62.2 +/- 8.0 kg) and TBW (63.9 +/- 7.8 kg) showed no differences among the techniques. Similarly, there were neither differences in fat mass nor percent body fat among the methods. Analysis of the chemical composition of FFBM of this group showed TBK/FFBM = 62.6 +/- 2.3 mEq/kg, TBW/FFBM = 74.6 +/- 0.2%, TBN/FFBM = 32.74 +/- 1.09 g/kg, protein/FFBM = 20.5+/- 0.7%. The calculated mineral content of the FFBM was 6.4%. These values are strikingly similar to the values calculated by direct chemical analysis. It was concluded that the combined TBN-TBK method is a valid technique for estimating body composition in man.

  5. Product and rate determinations with chemically activated nucleotides in the presence of various prebiotic materials, including other mono- and polynucleotides

    NASA Technical Reports Server (NTRS)

    Kanavarioti, A.; Alberas, D. J.; Rosenbach, M. T.; Bernasconi, C. F.; Chang, S.

    1991-01-01

    We are investigating the reactions of ImpN's in the presence of a number of prebiotically plausible materials, such as metal ions, phosphate, amines and other nucleotides and hope to learn more about the stability/reactivity of ImpN's in a prebiotic aqueous environment. We find that, in the presence of phosphate, ImpN's form substantial amounts of diphosphate nucleotides. These diphosphate nucleotides are not very good substrates for template directed reactions, but are chemically activated and are known to revert to the phosphoimidazolides in the presence of imidazole under solid state conditions. With respect to our studies of the oligomerization reaction, the determination of the dimerization rate constant of a specific ImpN (guanosine 5'-phospho 2 methylimidazolide) both in the absence and the presence of the template leads to the conclusion that at 37 C the dimerization is not template directed, although the subsequent polymerization steps are. In other words, this specific polynucleotide synthesizing system favors the elongation of oligonucleotides as compared with the formation of dimers and trimers. This favoring of the synthesis of long as opposed to short oligonucleotides may be regarded as a rudimentary example of natural selection at the molecular level.

  6. Crew Exploration Vehicle (CEV) (Orion) Occupant Protection. Part 1; Appendices

    NASA Technical Reports Server (NTRS)

    Currie-Gregg, Nancy J.; Gernhardt, Michael L.; Lawrence, Charles; Somers, Jeffrey T.

    2016-01-01

    Dr. Nancy J. Currie, of the NASA Engineering and Safety Center (NESC), Chief Engineer at Johnson Space Center (JSC), requested an assessment of the Crew Exploration Vehicle (CEV) occupant protection as a result of issues identified by the Constellation Program and Orion Project. The NESC, in collaboration with the Human Research Program (HRP), investigated new methods associated with occupant protection for the Crew Exploration Vehicle (CEV), known as Orion. The primary objective of this assessment was to investigate new methods associated with occupant protection for the CEV, known as Orion, that would ensure the design provided minimal risk to the crew during nominal and contingency landings in an acceptable set of environmental and spacecraft failure conditions. This documents contains the appendices to the NESC assessment report. NASA/TM-2013-217380, Application of the Brinkley Dynamic Response Criterion to Spacecraft Transient Dynamic Events supersedes this document.

  7. International Space Station (ISS) Anomalies Trending Study. Volume II; Appendices

    NASA Technical Reports Server (NTRS)

    Beil, Robert J.; Brady, Timothy K.; Foster, Delmar C.; Graber, Robert R.; Malin, Jane T.; Thornesbery, Carroll G.; Throop, David R.

    2015-01-01

    The NASA Engineering and Safety Center (NESC) set out to utilize data mining and trending techniques to review the anomaly history of the International Space Station (ISS) and provide tools for discipline experts not involved with the ISS Program to search anomaly data to aid in identification of areas that may warrant further investigation. Additionally, the assessment team aimed to develop an approach and skillset for integrating data sets, with the intent of providing an enriched data set for discipline experts to investigate that is easier to navigate, particularly in light of ISS aging and the plan to extend its life into the late 2020s. This document contains the Appendices to the Volume I report.

  8. Emerging Communication Technologies (ECT) Phase 2 Report. Volume 2; Appendices

    NASA Technical Reports Server (NTRS)

    Bastin, Gary L.; Harris, William G.; Chiodini, Robert; Nelson, Richard A.; Huang, PoTien; Kruhm, David A.

    2003-01-01

    The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB

  9. Effect of the Heat-exposure on Peripheral Sudomotor Activity Including the Density of Active Sweat Glands and Single Sweat Gland Output.

    PubMed

    Lee, Jeong-Beom; Kim, Tae-Wook; Shin, Young-Oh; Min, Young-Ki; Yang, Hun-Mo

    2010-10-01

    Tropical inhabitants are able to tolerate heat through permanent residence in hot and often humid tropical climates. The goal of this study was to clarify the peripheral mechanisms involved in thermal sweating pre and post exposure (heat-acclimatization over 10 days) by studying the sweating responses to acetylcholine (ACh), a primary neurotransmitter of sudomotor activity, in healthy subjects (n=12). Ten percent ACh was administered on the inner forearm skin for iontophoresis. Quantitative sudomotor axon reflex testing, after iontophoresis (2 mA for 5 min) with ACH, was performed to determine directly activated (DIR) and axon reflex-mediated (AXR) sweating during ACh iontophoresis. The sweat rate, activated sweat gland density, sweat gland output per single gland activated, as well as oral and skin temperature changes were measured. The post exposure activity had a short onset time (p<0.01), higher active sweat rate [(AXR (p<0.001) and DIR (p<0.001)], higher sweat output per gland (p<0.001) and higher transepidermal water loss (p<0.001) compared to the pre-exposure measurements. The activated sweat rate in the sudomotor activity increased the output for post-exposure compared to the pre-exposure measurements. The results suggested that post-exposure activity showed a higher active sweat gland output due to the combination of a higher AXR (DIR) sweat rate and a shorter onset time. Therefore, higher sudomotor responses to ACh receptors indicate accelerated sympathetic nerve responsiveness to ACh sensitivity by exposure to environmental conditions.

  10. Shipping container response to severe highway and railway accident conditions: Appendices

    SciTech Connect

    Fischer, L.E.; Chou, C.K.; Gerhard, M.A.; Kimura, C.Y.; Martin, R.W.; Mensing, R.W.; Mount, M.E.; Witte, M.C.

    1987-02-01

    Volume 2 contains the following appendices: Severe accident data; truck accident data; railroad accident data; highway survey data and bridge column properties; structural analysis; thermal analysis; probability estimation techniques; and benchmarking for computer codes used in impact analysis. (LN)

  11. Environmental radiological studies downstream from the Rancho Seco Nuclear Power Generating Station - 1985. Appendices. Part II

    SciTech Connect

    Noshkin, V.E.; Wong, K.M.; Eagle, R.J.; Brunk, J.L.; Jokela, T.A.

    1986-01-23

    Eight appendices address the following concentrations of radionuclides: in fish; in frog legs; in crayfish; in sediments; in soil samples; in surface and ground water samples; in water hyacinths; and in beef samples.

  12. Component Fragility Research Program: Phase 1, Demonstration tests: Volume 2, Appendices

    SciTech Connect

    Holman, G.S.; Chou, C.K.; Shipway, G.D.; Glozman, V.

    1987-08-01

    Appendices are presented which contain information concerning: details of controller and relay installation; resonance search transmissibility plots; time-history data from runs 17, 31, 46, and 56; and response spectra from runs 17, 31, 46, and 56. (JDB)

  13. Shuttle payload interface verification equipment study. Volume 2: Technical document. Part 2: Appendices

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Appendices to the shuttle payload integration study provide for: (1) The interface verification equipment hardware utilization list; (2) the horizontal IVE in-field assembly procedure; and (3) payload integration baseline functional flow block diagrams and options.

  14. RF model of the distribution system as a communication channel, phase 2. Volume 3: Appendices

    NASA Technical Reports Server (NTRS)

    Rustay, R. C.; Gajjar, J. T.; Rankin, R. W.; Wentz, R. C.; Wooding, R.

    1982-01-01

    Program documentation concerning the design, implementation, and verification of a computerized model for predicting the steady-state sinusoidal response of radial configured distribution feeders is presented in these appendices.

  15. High water-stressed population estimated by world water resources assessment including human activities under SRES scenarios

    NASA Astrophysics Data System (ADS)

    Kiguchi, M.; Shen, Y.; Kanae, S.; Oki, T.

    2009-04-01

    In an argument of the reduction and the adaptation for the climate change, the evaluation of the influence by the climate change is important. When we argue in adaptation plan from a damage scale and balance with the cost, it is particularly important. Parry et al (2001) evaluated the risks in shortage of water, malaria, food, the risk of the coast flood by temperature function and clarified the level of critical climate change. According to their evaluation, the population to be affected by the shortage of water suddenly increases in the range where temperature increases from 1.5 to 2.0 degree in 2080s. They showed how much we need to reduce emissions in order to draw-down significantly the number at risk. This evaluation of critical climate change threats and targets of water shortage did not include the water withdrawal divided by water availability. Shen et al (2008a) estimated the water withdrawal of projection of future world water resources according to socio-economic driving factors predicted for scenarios A1b, A2, B1, and B2 of the Special Report on Emission Scenarios (SRES). However, these results were in function of not temperature but time. The assessment of the highly water-stressed population considered the socioeconomic development is necessary for a function of the temperature. Because of it is easy to understand to need to reduce emission. We present a multi-GCM analysis of the global and regional populations lived in highly water-stressed basin for a function of the temperature using the socioeconomic data and the outputs of GCMs. In scenario A2, the population increases gradually with warming. On the other hand, the future projection population in scenario A1b and B1 increase gradually until the temperature anomaly exceeds around from +1 to +1.5 degree. After that the population is almost constant. From Shen et al (2008b), we evaluated the HWSP and its ratio in the world with temperature function for scenarios A1B, A2, and B1 by the index of W

  16. Economic evaluation of the annual cycle energy system (ACES). Final report. Volume III, appendices

    SciTech Connect

    Not Available

    1980-06-01

    This volume consists of seven appendices related to ACES, the first three of which are concerned with computer programs. The appendices are entitled: (A) ACESIM: Residential Program Listing; (B) Typical Inputs and Outputs of ACESIM; (C) CACESS: Commercial Building Program Listing; (D) Typical Weather-Year Selection Requirements; (E) Building Characteristics; (F) List of Major Variables Used in the Computer Programs; and (G) Bibliography. 79 references.

  17. NASAwide electronic publishing system-prototype STI electronic document distribution: Stage-4 evaluation report. Part 2; Appendices

    NASA Technical Reports Server (NTRS)

    Tuey, Richard C.; Collins, Mary; Caswell, Pamela; Haynes, Bob; Nelson, Michael L.; Holm, Jeanne; Buquo, Lynn; Tingle, Annette; Cooper, Bill; Stiltner, Roy

    1996-01-01

    This evaluation report contains an introduction, seven chapters, and five appendices. The Introduction describes the purpose, conceptual framework, functional description, and technical report server of the Scientific and Technical Information (STI) Electronic Document Distribution (EDD) project. Chapter 1 documents the results of the prototype STI EDD in actual operation. Chapter 2 documents each NASA center's post processing publication processes. Chapter 3 documents each center's STI software, hardware. and communications configurations. Chapter 7 documents STI EDD policy, practices, and procedures. The appendices consist of (A) the STI EDD Project Plan, (B) Team members, (C) Phasing Schedules, (D) Accessing On-line Reports, and (E) Creating an HTML File and Setting Up an xTRS. In summary, Stage 4 of the NASAwide Electronic Publishing System is the final phase of its implementation through the prototyping and gradual integration of each NASA center's electronic printing systems, desk top publishing systems, and technical report servers, to be able to provide to NASA's engineers, researchers, scientists, and external users, the widest practicable and appropriate dissemination of information concerning its activities and the result thereof to their work stations.

  18. Mesh Inguinal Hernia Repair and Appendectomy in the Treatment of Amyand's Hernia with Non-Inflamed Appendices

    PubMed Central

    Kose, Emin; Sisik, Abdullah

    2017-01-01

    Amyand's hernia is defined as protrusion of the vermiform appendix in an inguinal hernia sac. It is a rare entity with variable clinical presentation from normal vermiform appendix to abscess formation due to perforation of acute appendicitis. Although surgical treatment includes appendectomy and hernia repair, appendectomy in the absence of an inflamed appendix and use of a mesh in cases of appendectomy remain to be controversial. The aim of this study was to review the experience of mesh inguinal hernia repair plus appendectomy performed for Amyand's hernia with noninflamed appendices. There were five male patients with a mean age of 42.4 ± 16.1 years in this retrospective study in which Amyand's hernia was treated with mesh inguinal hernia repair plus appendectomy for noninflamed appendices. Patients with acute appendicitis and perforated vermiform appendix were excluded. There were four right sided and one bilateral inguinal hernia. Postoperative courses were uneventful. During the follow-up period (14.0 ± 7.7 months), there was no inguinal hernia recurrence. Mesh inguinal hernia repair with appendectomy can be performed for Amyand's hernia in the absence of acute appendicitis. However, presence of fibrous connections between the vermiform appendix and the surrounding hernia sac may be regarded as a parameter to perform appendectomy. PMID:28194430

  19. Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

    SciTech Connect

    Hinga, K.R.

    1981-07-01

    Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base.

  20. The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.

    PubMed

    Liu, Ke; Zhang, Xiping; Lester, Robert L; Dickson, Robert C

    2005-06-17

    The Pkh1 protein kinase of Saccharomyces cerevisiae, a homolog of the mammalian 3-phosphoinositide-dependent kinase (PDK1), regulates downstream AGC-type protein kinases including Ypk1/2 and Pkc1, which control cell wall integrity, growth, and other processes. Phytosphingosine (PHS), a sphingoid long chain base, is hypothesized to be a lipid activator of Pkh1 and thereby controls the activity of Ypk1/2. Here we present biochemical evidence supporting this hypothesis, and in addition we demonstrate that PHS also stimulates autophosphorylation and activation of Ypk1/2. Greatest stimulation of Ypk1/2 phosphorylation and activity are achieved by inclusion of both PHS and Pkh1 in an in vitro kinase reaction. We also demonstrate for the first time that Pkh1 phosphorylates the Sch9 protein kinase in vitro and that such phosphorylation is stimulated by PHS. This is the first biochemical demonstration of Sch9 activators, and the results further support roles for long chain bases in heat stress resistance in addition to implying roles in chronological aging and cell size determination, since Sch9 functions in these processes. Thus, our data support a model in which PHS, rather than simply being an upstream activator of Pkh1, also activates kinases that are downstream targets of Pkh1 including Ypk1/2 and Sch9.

  1. Zimmer slipstream magnesium hydroxide recovery demonstration. Volume II of II. Appendices

    SciTech Connect

    1998-03-01

    Dravo Lime has for many years supplied magnesium containing lime in the ranges of 3-6% MgO. Several years ago Dravo Lime realized the potential operating savings its FGD customers could benefit from if magnesium could be recovered from FGD waste streams. As a result, several different proprietary processes have been developed for the recovery of magnesium hydroxide. These recovery processes include steps for magnesium hydroxide separation, purification, and crystal growth. The process implemented at The Cincinnati Gas Electric Company`s Wm. H. Zimmer Station was piloted by Dravo Lime Company at Allegheny Power System`s Mitchell Station near Monongahela, PA during the fourth quarter in 1989 and first quarter in 1990. This pilot work was the foundation for further development of the ThioClear process at Dravo`s pilot plant at CG&E Miami Fort Station. The ThioClear process is a closed loop version of the magnesium hydroxide recovery process with the same unit operations and products but also including an absorber tower for scrubbing flue gas. Testing at Miami Fort of the ThioClear process led to improvements in separation of magnesium hydroxide from gypsum that are part of the magnesium hydroxide recovery process installed at Zimmer Station. This document contains the Appendices for this report.

  2. Including Youth with Intellectual Disabilities in Health Promotion Research: Development and Reliability of a Structured Interview to Assess the Correlates of Physical Activity among Youth

    ERIC Educational Resources Information Center

    Curtin, Carol; Bandini, Linda G.; Must, Aviva; Phillips, Sarah; Maslin, Melissa C. T.; Lo, Charmaine; Gleason, James M.; Fleming, Richard K.; Stanish, Heidi I.

    2016-01-01

    Background: The input of youth with intellectual disabilities in health promotion and health disparities research is essential for understanding their needs and preferences. Regular physical activity (PA) is vital for health and well-being, but levels are low in youth generally, including those with intellectual disabilities. Understanding the…

  3. Power Systems for Future Missions: Appendices A-L

    NASA Technical Reports Server (NTRS)

    Gill, S. P.; Frye, P. E.; Littman, Franklin D.; Meisl, C. J.

    1994-01-01

    Selection of power system technology for space applications is typically based on mass, readiness of a particular technology to meet specific mission requirements, and life cycle costs (LCC). The LCC is typically used as a discriminator between competing technologies for a single mission application. All other future applications for a given technology are usually ignored. As a result, development cost of a technology becomes a dominant factor in the LCC comparison. Therefore, it is common for technologies such as DIPS and LMR-CBC to be potentially applicable to a wide range of missions and still lose out in the initial LCC comparison due to high development costs. This collection of appendices (A through L) contains the following power systems technology plans: CBC DIPS Technology Roadmap; PEM PFC Technology Roadmap; NAS Battery Technology Roadmap; PV/RFC Power System Technology Roadmap; PV/NAS Battery Technology Roadmap; Thermionic Reactor Power System Technology Roadmap; SP-100 Power System Technology Roadmap; Dynamic SP-100 Power System Technology Roadmap; Near-Term Solar Dynamic Power System Technology Roadmap; Advanced Solar Dynamic Power System Technology Roadmap; Advanced Stirling Cycle Dynamic Isotope Power System Technology Roadmap; and the ESPPRS (Evolutionary Space Power and Propulsion Requirements System) User's Guide.

  4. Ocean Thermal Energy Conversion (OTEC) Programmatic Environmental Analysis--Appendices

    SciTech Connect

    Authors, Various

    1980-01-01

    The programmatic environmental analysis is an initial assessment of Ocean Thermal Energy Conversion (OTEC) technology considering development, demonstration and commercialization. It is concluded that the OTEC development program should continue because the development, demonstration, and commercialization on a single-plant deployment basis should not present significant environmental impacts. However, several areas within the OTEC program require further investigation in order to assess the potential for environmental impacts from OTEC operation, particularly in large-scale deployments and in defining alternatives to closed-cycle biofouling control: (1) Larger-scale deployments of OTEC clusters or parks require further investigations in order to assess optimal platform siting distances necessary to minimize adverse environmental impacts. (2) The deployment and operation of the preoperational platform (OTEC-1) and future demonstration platforms must be carefully monitored to refine environmental assessment predictions, and to provide design modifications which may mitigate or reduce environmental impacts for larger-scale operations. These platforms will provide a valuable opportunity to fully evaluate the intake and discharge configurations, biofouling control methods, and both short-term and long-term environmental effects associated with platform operations. (3) Successful development of OTEC technology to use the maximal resource capabilities and to minimize environmental effects will require a concerted environmental management program, encompassing many different disciplines and environmental specialties. This volume contains these appendices: Appendix A -- Deployment Scenario; Appendix B -- OTEC Regional Characterization; and Appendix C -- Impact and Related Calculations.

  5. Final environmental impact statement. Management of commercially generated radioactive waste. Volume 2. Appendices

    SciTech Connect

    Not Available

    1980-10-01

    This EIS analyzes the significant environmental impacts that could occur if various technologies for management and disposal of high-level and transuranic wastes from commercial nuclear power reactors were to be developed and implemented. This EIS will serve as the environmental input for the decision on which technology, or technologies, will be emphasized in further research and development activities in the commercial waste management program. The action proposed in this EIS is to (1) adopt a national strategy to develop mined geologic repositories for disposal of commercially generated high-level and transuranic radioactive waste (while continuing to examine subseabed and very deep hole disposal as potential backup technologies) and (2) conduct a R and D program to develop such facilities and the necessary technology to ensure the safe long-term containment and isolation of these wastes. The Department has considered in this statement: development of conventionally mined deep geologic repositories for disposal of spent fuel from nuclear power reactors and/or radioactive fuel reprocessing wastes; balanced development of several alternative disposal methods; and no waste disposal action. This volume contains appendices of supplementary data on waste management systems, geologic disposal, radiological standards, radiation dose calculation models, related health effects, baseline ecology, socio-economic conditions, hazard indices, comparison of defense and commercial wastes, design considerations, and wastes from thorium-based fuel cycle alternatives. (DMC)

  6. N+3 Aircraft Concept Designs and Trade Studies. Volume 2; Appendices-Design Methodologies for Aerodynamics, Structures, Weight, and Thermodynamic Cycles

    NASA Technical Reports Server (NTRS)

    Greitzer, E. M.; Bonnefoy, P. A.; delaRosaBlanco, E.; Dorbian, C. S.; Drela, M.; Hall, D. K.; Hansman, R. J.; Hileman, J. I.; Liebeck, R. H.; Lovegren, J.; Mody, P.; Pertuze, J. A.; Sato, S.; Spakovszky, Z. S.; Tan, C. S.; Hollman, J. S.; Duda, J. E.; Fitzgerald, N.; Houghton, J.; Kerrebrock, J. L.; Kiwada, G. F.; Kordonowy, D.; Parrish, J. C.; Tylko, J.; Wen, E. A.

    2010-01-01

    Appendices A to F present the theory behind the TASOPT methodology and code. Appendix A describes the bulk of the formulation, while Appendices B to F develop the major sub-models for the engine, fuselage drag, BLI accounting, etc.

  7. Probabilistic accident consequence uncertainty analysis -- Early health effects uncertainty assessment. Volume 2: Appendices

    SciTech Connect

    Haskin, F.E.; Harper, F.T.; Goossens, L.H.J.; Kraan, B.C.P.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA early health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on early health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  8. Probabilistic accident consequence uncertainty analysis -- Uncertainty assessment for deposited material and external doses. Volume 2: Appendices

    SciTech Connect

    Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M.; Boardman, J.; Jones, J.A.; Harper, F.T.; Young, M.L.; Hora, S.C.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA deposited material and external dose models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on deposited material and external doses, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  9. Probabilistic accident consequence uncertainty analysis -- Late health effects uncertain assessment. Volume 2: Appendices

    SciTech Connect

    Little, M.P.; Muirhead, C.R.; Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M.; Harper, F.T.; Hora, S.C.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA late health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the expert panel on late health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  10. Deschutes River Spawning Gravel Study, Volume II, Appendices I-XIV, Final Report.

    SciTech Connect

    Huntington, Charles W.

    1985-09-01

    Spawning habitat in the Deschutes River was inventoried, gravel permeability and composition were sampled at selected gravel bars, historical flow records for the Deschutes were analyzed, salmon and trout utilization of spawning habitat was examined, and potential methods of enhancing spawning habitat in the river were explored. Some changes in river conditions since the mid-1960's were identified, including a reduction in spawning habitat immediately downstream from the hydroelectric complex. The 1964 flood was identified as a factor which profoundly affected spawning habitat in the river, and which greatly complicated efforts to identify recent changes which could be attributed to the hydrocomplex. A baseline on present gravel quality at both chinook and steelhead spawning areas in the river was established using a freeze-core methodology. Recommendations are made for enhancing spawning habitat in the Deschutes River, if it is independently determined that spawning habitat is presently limiting populations of summer steelhead or fall chinook in the river. Volume II contains appendices to the study.

  11. MELSAR: a mesoscale air quality model for complex terrain. Volume 2. Appendices

    SciTech Connect

    Allwine, K.J.; Whiteman, C.D.

    1985-04-01

    This final report is submitted as part of the Green River Ambient Model Assessment (GRAMA) project conducted at the US Department of Energy's Pacific Northwest Laboratory for the US Environmental Protection Agency. The GRAMA Program has, as its ultimate goal, the development of validated air quality models that can be applied to the complex terrain of the Green River Formation of western Colorado, eastern Utah and southern Wyoming. The Green River Formation is a geologic formation containing large reserves of oil shale, coal, and other natural resources. Development of these resources may lead to a degradation of the air quality of the region. Air quality models are needed immediately for planning and regulatory purposes to assess the magnitude of these regional impacts. This report documents one of the models being developed for this purpose within GRAMA - specifically a model to predict short averaging time (less than or equal to 24 h) pollutant concentrations resulting from the mesoscale transport of pollutant releases from multiple sources. MELSAR has not undergone any rigorous operational testing, sensitivity analyses, or validation studies. Testing and evaluation of the model are needed to gain a measure of confidence in the model's performance. This report consists of two volumes. This volume contains the Appendices, which include listings of the FORTRAN code and Volume 1 contains the model overview, technical description, and user's guide. 13 figs., 10 tabs.

  12. Residential Wood Combustion Study. Task 5. Emissions testing of wood stoves. Volumes 3 and 4 (Appendices)

    SciTech Connect

    Not Available

    1982-11-01

    This report contains the appendices for the results of 19 emission tests on four wood stoves and two retrofit emission control devices (reported in PB84-170638). The objectives of the study were to further identify the effect of wood moisture on stove emissions, to evaluate several inexpensive (simplified) test procedures for assessing particulate emissions, and to define a level of particulate emissions which can be expected from state-of-the-art improved combustion stoves. This study included evaluating previous test data reported in the literature. A single standard operating procedure was used throughout the test program, the objective of which was to maintain a constant heat output rate, as monitored by combustion chamber temperature and stove surface temperature. A heat output rate corresponding to a relatively moderate to low burn rate (less than 2.5 kg wood/hour) was chosen. A single wood type (Douglas fir) was used throughout the study; wood size was maintained at a consistent level. Throughout the entire test program measurements were made for particulate, carbon monoxide, carbon dioxide, oxygen, and hydrocarbon content of the emissions; the gaseous constituents were monitored continuously. Measurements were made for creosote deposition, opacity, and smoke spot density.

  13. Probabilistic accident consequence uncertainty analysis -- Uncertainty assessment for internal dosimetry. Volume 2: Appendices

    SciTech Connect

    Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M.; Harrison, J.D.; Harper, F.T.; Hora, S.C.

    1998-04-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA internal dosimetry models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on internal dosimetry, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  14. Aeronautics and Space Report of the President: Fiscal Year 1996 Activities

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Topics considered include: (1) Space launch activities: space shuttle missions; expendable launch vehicles. (2) Space science: astronomy and space physics; solar system exploration. (3) Space flight and technology: life and microgravity sciences; space shuttle technology; reuseable launch vehicles; international space station; energy; safety and mission assurance; commercial development and regulation of space; surveillance. (4) Space communications: communications satellites; space network; ground networks; mission control and data systems. (5) Aeronautical activities: technology developments; air traffic control and navigation; weather-related aeronautical activities; flight safety and security; aviation medicine and human factors. (6) Studies of the planet earth: terrestrial studies and applications: atmospheric studies: oceanographic studies; international aeronautical and space activities; and appendices.

  15. A proposed 30-45 minute 4 page standard protocol to evaluate rheumatoid arthritis (SPERA) that includes measures of inflammatory activity, joint damage, and longterm outcomes.

    PubMed

    Pincus, T; Brooks, R H; Callahan, L F

    1999-02-01

    A proposed 4 page, 30-45 minute standard protocol to assess rheumatoid arthritis (SPERA) is described that includes all relevant measures of inflammatory activity such as joint swelling, measures of joint damage such as joint deformity, and outcomes such as joint replacement surgery, to monitor patients in longterm observational studies. Forms are included: (1) a patient self-report modified health assessment questionnaire (MHAQ) to assess function, pain, fatigue, psychological distress, symptoms, and drugs used; (2) assessor-completed forms: "RA clinical features" --criteria for RA, functional class, family history, extraarticular disease, comorbidities, joint surgery, radiographic score, and laboratory findings. (3) A 32 joint count with 5 variables: (a) a "shorthand" normal/abnormal so that normal joints require no further detailed assessment; (b) tenderness or pain on motion; (c) swelling; (d) limited motion or deformity; (e) previous surgeries; physical measures of function, i.e., grip strength, walk time, and button test. (4) Medication review of previous disease modifying antirheumatic drugs (DMARD), work history, and years of education. The forms allow cost effective acquisition of all relevant measures of activity, damage, and outcomes in routine clinical care, and allow recognition that measures of activity may show similar or improved values over 5-10 years, while measures of damage and outcomes indicate severe progression in the same patients. The SPERA is feasible to acquire most known relevant measures of activity, damage, and outcomes in RA in 30-45 min in usual clinical settings, to provide a complete database for analyses of longterm outcomes.

  16. 76 FR 63538 - Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... 6 Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the 2011... sets forth the revised appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the... dairy product import licenses permanently surrendered by licensees or revoked by the Licensing...

  17. 75 FR 53565 - Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the 2010...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... 6 Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the 2010... sets forth the revised appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the... dairy product import licenses permanently surrendered by licensees or revoked by the Licensing...

  18. 78 FR 46491 - Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the 2013...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ... 7 CFR Part 6 Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for...: This document sets forth the revised appendices to the Dairy Tariff-Rate Import Quota Licensing... for certain dairy product import licenses permanently surrendered by licensees or revoked by...

  19. 77 FR 51681 - Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for the 2012...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... 7 CFR Part 6 Adjustment of Appendices to the Dairy Tariff-Rate Import Quota Licensing Regulation for...: This document sets forth the revised appendices to the Dairy Tariff-Rate Import Quota Licensing... for certain dairy product import licenses permanently surrendered by licensees or revoked by...

  20. Ocean Optics Protocols for Satellite Ocean Color Sensor Validation. Volume 6; Special Topics in Ocean Optics Protocols and Appendices; Revised

    NASA Technical Reports Server (NTRS)

    Mueller, J. L. (Editor); Fargion, Giulietta S. (Editor); McClain, Charles R. (Editor)

    2003-01-01

    This document stipulates protocols for measuring bio-optical and radiometric data for the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) Project activities and algorithm development. The document is organized into 6 separate volumes as Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 4. Volume I: Introduction, Background and Conventions; Volume II: Instrument Specifications, Characterization and Calibration; Volume III: Radiometric Measurements and Data Analysis Methods; Volume IV: Inherent Optical Properties: Instruments, Characterization, Field Measurements and Data Analysis Protocols; Volume V: Biogeochemical and Bio-Optical Measurements and Data Analysis Methods; Volume VI: Special Topics in Ocean Optics Protocols and Appendices. The earlier version of Ocean Optics Protocols for Satellite Ocean Color Sensor Validation, Revision 3 (Mueller and Fargion 2002, Volumes 1 and 2) is entirely superseded by the six volumes of Revision 4 listed above.

  1. Fate and effects of nearshore discharges of OCS produced waters. Volume 3. Appendices. Final report. [Outer Continental Shelf

    SciTech Connect

    Rabalais, N.N.; McKee, B.A.; Reed, D.J.; Means, J.C.

    1991-06-01

    A total of 253,944/bbl.d produced waters originate in the Federal OCS but are piped ashore for treatment and discharge in Louisiana State waters. The volume represents 13% of all produced waters discharged into Louisiana's waters. Elevated levels of dissolved solids (salinity), volatile organic hydrocarbons, sulfides, and total radium activities identified contaminants of the brine effluent in waters overlying the sediments. Sediments up to 1,300 m from the produced water discharges exhibited evidence of contamination by petrogenic hydrocarbons from the effluents. Effects on the benthic macroinfauna were demonstrated at most of the study sites. Oysters in close proximity to the discharge points and at great distances from the discharges accumulated produced water origin contaminants. The volume contains the appendices for volumes 1 and 2.

  2. The appendiceal stump closure during laparoscopy: historical, surgical, and future perspectives.

    PubMed

    Gomes, Carlos Augusto; Nunes, Tarcizo Afonso; Soares, Cleber; Gomes, Camila Couto

    2012-02-01

    During a laparoscopic appendectomy, the closure of the appendiceal stump is an important step because of postoperative complications from its inappropriate management. The development of life-threatening events such as stercoral fistulas, postoperative peritonitis, and sepsis is feared and unwanted. The tactical modification of the appendiceal stump closure with a single endoligature, replacing the invaginating suture, adjusted very well to laparoscopic appendectomy, and nowadays is the procedure of choice, whenever possible. Among the alternatives that do not make use of an invaginating suture, studies advocate the use of an endostapler, endoligature (endo-loop), metal clips, bipolar endocoagulation, and polymeric clips. All alternatives have advantages and disadvantages against the different clinical stages of acute appendicitis, and it should be noted that the different forms of appendiceal stump closure have never been assessed in prospective randomized studies. Knowledge about and appropriate use of all of them are important for a safe and more cost-effective procedure.

  3. The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts

    PubMed Central

    Hendrayani, Siti-Fauziah; Al-Harbi, Bothaina; Al-Ansari, Mysoon M.; Silva, Gabriela; Aboussekhra, Abdelilah

    2016-01-01

    The IL-6/STAT3/NF-κB positive feedback loop links inflammation to cancer and maintains cells at a transformed state. Similarly, cancer-associated myofibroblats remains active even in absence of cancer cells. However, the molecular basis of this sustained active state remains elusive. We have shown here that breast cancer cells and IL-6 persistently activate breast stromal fibroblasts through the stimulation of the positive IL-6/STAT3/NF-κB feedback loop. Transient neutralization of IL-6 in culture inhibited this signaling circuit and reverted myofibrobalsts to a normalized state, suggesting the implication of the IL-6 autocrine feedback loop as well. Importantly, the IL-6/STAT3/NF-κB pro-inflammatory circuit was also active in cancer-associated fibroblasts isolated from breast cancer patients. Transient inhibition of STAT3 by specific siRNA in active fibroblasts persistently reduced the level of the RNA binding protein AUF1, blocked the loop and normalized these cells. Moreover, we present clear evidence that AUF1 is also part of this positive feedback loop. Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1. These results indicate that the IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and is responsible for the sustained active status of cancer-associated fibroblasts. We have also shown that normalizing myofibroblasts, which could be of great therapeutic value, is possible through the inhibition of this procarcinogenic circuit. PMID:27248826

  4. Feasibility study for a 40-MGY/80-MGY fuel-alcohol production plant. Volume 1. Appendices. Executive overview. [Alabama

    SciTech Connect

    Not Available

    1982-09-01

    The results of a study to determine the technical and economic feasibility of constructing and operating a 40 to 80 million gallon per year alcohol fuels plant in Talladega County, Alabama are presented. This volume briefly outlines the transformation of the US fermentation industry since its inception in 1979; identifies the current status of the ethanol industry including its existing resources and markets; assesses the most important factors which will effect the development of the industry; and provides an assessment of the impact of GRASP's proposed facility on the US ethanol market. In addition, this document contains 7 appendices entitled: total US ethanol production capacity; US gasohol sales; regional refineries; fermentation ethanol imports for fuel use; state excise tax exemptions; alcohol fuels industry report; and US corn production and prices. (DMC)

  5. Wakame and Nori in restructured meats included in cholesterol-enriched diets affect the antioxidant enzyme gene expressions and activities in Wistar rats.

    PubMed

    Moreira, Adriana Schultz; González-Torres, Laura; Olivero-David, Raul; Bastida, Sara; Benedi, Juana; Sánchez-Muniz, Francisco J

    2010-09-01

    The effects of diets including restructured meats (RM) containing Wakame or Nori on total liver glutathione status, and several antioxidant enzyme gene expressions and activities were tested. Six groups of ten male growing Wistar rats each were fed a mix of 85% AIN-93 M diet and 15% freeze-dried RM for 35 days. The control group (C) consumed control RM, the Wakame (W) and the Nori (N) groups, RM with 5% Wakame and 5% Nori, respectively. Animals on added cholesterol diets (CC, CW, and CN) consumed their corresponding basal diets added with cholesterol (2%) and cholic acid (0.4%). Alga and dietary cholesterol significantly interact (P < 0.002) influencing all enzyme expressions but not activities. The cholesterol supplement decreased most enzyme expression and activity. W-RM vs. C-RM increased (P < 0.05) expression of GPx, GR, Mn-SOD, and Cu,Zn-SOD and decreased that of catalase. N-RM vs. C-RM increased (P < 0.05) expression of catalase and Mn-SOD. GR activity increased in W-RM rats while SOD activity increased, but that of Se-GPx decreased in N animals. W-RM increased total and reduced glutathione and decreased the redox index. CN diet induced significantly lower plasma cholesterol levels (P < 0.001) than the CW diet. In conclusion, Nori-RM is a hypocholesterolemic food while Wakame-RM is an antioxidant food. This should be taken into account when including this kind of RM as potential functional foods in human.

  6. [Appendiceal carcinoid: report of 3 clinical cases and review of the literature].

    PubMed

    Bronzino, P; Cassinelli, G; Cuneo, A; Rassu, P C; Partipilo, F; Bianchi, M; Casaccia, M

    2003-05-01

    The Authors report three cases of appendiceal carcinoids, found during appendectomy for acute appendicitis during the last 15 years. Appendiceal carcinoid is a rare neoplasm, more frequent in females age ranging between 20 and 29 years. Lack of symptoms explains the occasional diagnosis of this disease. The prognosis is related mostly to the size of the tumor, local and lymphatic invasion, presence of metastases, localization inside the appendix, histological type and age of the patient. Therapy is mainly surgical and consists of appendectomy and right colectomy according to different criteria which are being discussed in this article.

  7. Diarrhea Concealing a Duodenal-Cecal Fistula Secondary to Appendiceal Mucinous Neoplasm

    PubMed Central

    Cheung, Amanda; Prather, Charlene; Lai, Jinping

    2017-01-01

    Primary mucinous adenocarcinoma of the appendix is a rare gastrointestinal malignancy. Fistulous tract formation is a complication that is cited in literature. An 85-year-old man with multiple comorbidities presented with several weeks of persistent non-bloody diarrhea. Laboratory work-up was non-diagnostic. Abdominal imaging with barium contrast showed an enterocolonic fistulous tract extending from the duodenum to the cecum involving an enlarged appendiceal mass. Subsequent biopsy confirmed mucinous appendiceal neoplasm with peritoneal spread to the liver and mesentery. This is the first report describing an enterocolonic fistula formation resulting from this malignancy. PMID:28138447

  8. An appendiceal neoplastic lesion: case report and implications for colonoscopic screening and surveillance.

    PubMed

    Freeman, Hugh J; Webber, Douglas L; Meneghetti, Adam T

    2009-05-01

    A 65-year-old man with a history of previously resected colonic adenomas had an apparent cecal lesion detected during colonoscopy. The polyp proved to be a tubulovillous adenoma with high-grade dysplasia involving most of the body of the appendix along with the base of the cecum. The appendiceal mucosa is biologically similar to the colonic mucosa, yet remains relatively 'hidden' in screening and surveillance studies, which suggests important implications for evolving detection strategies in the follow-up of patients with a previous colon polyp or cancer resections. Although endoscopic removal of the appendix has been reported, treatment of these localized appendiceal lesions requires a wide surgical excision.

  9. Applying the Model of Goal-Directed Behavior, Including Descriptive Norms, to Physical Activity Intentions: A Contribution to Improving the Theory of Planned Behavior.

    PubMed

    Esposito, Gabriele; van Bavel, René; Baranowski, Tom; Duch-Brown, Néstor

    2016-08-01

    The theory of planned behavior (TPB) has received its fair share of criticism lately, including calls for it to retire. We contribute to improving the theory by testing extensions such as the model of goal-directed behavior (MGDB, which adds desire and anticipated positive and negative emotions) applied to physical activity (PA) intention. We also test the inclusion of a descriptive norms construct as an addition to the subjective norms construct, also applied to PA, resulting in two additional models: TPB including descriptive norms (TPB + DN) and MGDB including descriptive norms (MGDB + DN). The study is based on an online survey of 400 young adult Internet users, previously enrolled in a subject pool. Confirmatory factor analysis (CFA) showed that TPB and TPB + DN were not fit for purpose, while MGDB and MGDB + DN were. Structural equation modelling (SEM) conducted on MGDB and MGDB + DN showed that the inclusion of descriptive norms took over the significance of injunctive norms, and increased the model's account of total variance in intention to be physically active.

  10. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the NPL

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; Woods, M. J.

    2003-01-01

    Since 2001, four national metrology institutes (NMIs) have submitted four samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures, the most recent being that of the NPL (UK). The activities ranged from about 1 MBq to 8 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value and the degrees of equivalence between each equivalent activity measured in the SIR and the key comparison reference value (KCRV) have been calculated and the results are given in the form of a matrix. A graphical presentation is also given. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), comparison identifier BIPM.RI(II)-K1.F-18, according to the provisions of the Mutual Recognition Arrangement (MRA).

  11. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the CIEMAT

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; García-Toraño, E.; Los Arcos, J.-M.

    2004-01-01

    Since 2001, five national metrology institutes (NMIs) have submitted five samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), the most recent being that of the CIEMAT (Spain). The activities ranged from about 1 MBq to 18 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value and the degrees of equivalence between each equivalent activity measured in the SIR have been calculated and the results are given in the form of a matrix. A graphical presentation is also given for this key comparison with identifier BIPM.RI(II)-K1.F-18. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), according to the provisions of the Mutual Recognition Arrangement (MRA).

  12. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the PTB

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; Kossert, K.; Janßen, H.

    2006-01-01

    Since 2001, six national metrology institutes (NMIs) have submitted six samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), the most recent being that of the PTB (Germany). The activities ranged from about 1 MBq to 18 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value, with the agreement of the CCRI(II). The degrees of equivalence between each equivalent activity measured in the SIR have been recalculated and the results are given in the form of a matrix. A graphical presentation is also given for this key comparison with identifier BIPM.RI(II)-K1.F-18. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), according to the provisions of the Mutual Recognition Arrangement (MRA).

  13. The Acoustic Model Evaluation Committee (AMEC) Reports. Volume 3. Evaluation of the RAYMODE X Propagation Loss Model. Book 2. Appendices A-D

    DTIC Science & Technology

    1982-09-01

    2 of 3 The Acasstic Model Evaluation Committee (AMEC) Reports Vodlme III, Appendices A-i) Elakiaie of Me RAYAODE X f*W#ton Loss Model (U) Prepared by...Richard B. Laer, NORDP Numerical Modefa Division 11N Pylos of RAYNONE X (g) ’T evy •u v ,ap,.,,.,.nDTiC hpWor 1984;& AELE TEfTE Aft 12 W~ LAJ...Activity NSTL Station, Mississippi 39529 84 04 06 511 CONFIDENTIAL .%.. CONFIDENTIAL Appendix IliA. Accuracy Assessment of RAYMODE X Compared to SUDS

  14. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  15. In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin.

    PubMed

    Endimiani, Andrea; Patel, Gopi; Hujer, Kristine M; Swaminathan, Mahesh; Perez, Federico; Rice, Louis B; Jacobs, Michael R; Bonomo, Robert A

    2010-01-01

    In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC(50/90) of 16/64 microg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC(50/90) of 32/128 microg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.

  16. Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.

    PubMed

    Phillips, Joshua B; Smith, Adrienne E; Kusche, Brian R; Bessette, Bradley A; Swain, P Whitney; Bergmeier, Stephen C; McMills, Mark C; Wright, Dennis L; Priestley, Nigel D

    2010-10-01

    We have shown that the intentional engineering of a natural product biosynthesis pathway is a useful way to generate stereochemically complex scaffolds for use in the generation of combinatorial libraries that capture the structural features of both natural products and synthetic compounds. Analysis of a prototype library based upon nonactic acid lead to the discovery of triazole-containing nonactic acid analogs, a new structural class of antibiotic that exhibits bactericidal activity against drug resistant, Gram-positive pathogens including Staphylococcus aureus and Enterococcus faecalis.

  17. Early Site Permit Demonstration Program: Guidelines for determining design basis ground motions. Volume 2, Appendices

    SciTech Connect

    Not Available

    1993-03-18

    This report develops and applies a methodology for estimating strong earthquake ground motion. The motivation was to develop a much needed tool for use in developing the seismic requirements for structural designs. An earthquake`s ground motion is a function of the earthquake`s magnitude, and the physical properties of the earth through which the seismic waves travel from the earthquake fault to the site of interest. The emphasis of this study is on ground motion estimation in Eastern North America (east of the Rocky Mountains), with particular emphasis on the Eastern United States and southeastern Canada. Eastern North America is a stable continental region, having sparse earthquake activity with rare occurrences of large earthquakes. While large earthquakes are of interest for assessing seismic hazard, little data exists from the region to empirically quantify their effects. The focus of the report is on the attributes of ground motion in Eastern North America that are of interest for the design of facilities such as nuclear power plants. This document, Volume II, contains Appendices 2, 3, 5, 6, and 7 covering the following topics: Eastern North American Empirical Ground Motion Data; Examination of Variance of Seismographic Network Data; Soil Amplification and Vertical-to-Horizontal Ratios from Analysis of Strong Motion Data From Active Tectonic Regions; Revision and Calibration of Ou and Herrmann Method; Generalized Ray Procedure for Modeling Ground Motion Attenuation; Crustal Models for Velocity Regionalization; Depth Distribution Models; Development of Generic Site Effects Model; Validation and Comparison of One-Dimensional Site Response Methodologies; Plots of Amplification Factors; Assessment of Coupling Between Vertical & Horizontal Motions in Nonlinear Site Response Analysis; and Modeling of Dynamic Soil Properties.

  18. Kinetic Structure of Large-Conductance Ca2+-activated K+ Channels Suggests that the Gating Includes Transitions through Intermediate or Secondary States

    PubMed Central

    Rothberg, Brad S.; Magleby, Karl L.

    1998-01-01

    Mechanisms for the Ca2+-dependent gating of single large-conductance Ca2+-activated K+ channels from cultured rat skeletal muscle were developed using two-dimensional analysis of single-channel currents recorded with the patch clamp technique. To extract and display the essential kinetic information, the kinetic structure, from the single channel currents, adjacent open and closed intervals were binned as pairs and plotted as two-dimensional dwell-time distributions, and the excesses and deficits of the interval pairs over that expected for independent pairing were plotted as dependency plots. The basic features of the kinetic structure were generally the same among single large-conductance Ca2+-activated K+ channels, but channel-specific differences were readily apparent, suggesting heterogeneities in the gating. Simple gating schemes drawn from the Monod- Wyman-Changeux (MWC) model for allosteric proteins could approximate the basic features of the Ca2+ dependence of the kinetic structure. However, consistent differences between the observed and predicted dependency plots suggested that additional brief lifetime closed states not included in MWC-type models were involved in the gating. Adding these additional brief closed states to the MWC-type models, either beyond the activation pathway (secondary closed states) or within the activation pathway (intermediate closed states), improved the description of the Ca2+ dependence of the kinetic structure. Secondary closed states are consistent with the closing of secondary gates or channel block. Intermediate closed states are consistent with mechanisms in which the channel activates by passing through a series of intermediate conformations between the more stable open and closed states. It is the added secondary or intermediate closed states that give rise to the majority of the brief closings (flickers) in the gating. PMID:9607935

  19. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates

    PubMed Central

    Pfaller, Michael A.; Messer, Shawn A.; Rhomberg, Paul R.; Jones, Ronald N.; Castanheira, Mariana

    2016-01-01

    Objectives The objective of this study was to evaluate the in vitro activity of CD101, a novel echinocandin with a long serum elimination half-life, and comparator (anidulafungin and caspofungin) antifungal agents against a collection of Candida and Aspergillus spp. isolates. Methods CD101 and comparator agents were tested against 106 Candida spp. and 67 Aspergillus spp. isolates, including 27 isolates of Candida harbouring fks hotspot mutations and 12 itraconazole non-WT Aspergillus, using CLSI and EUCAST reference susceptibility broth microdilution (BMD) methods. Results Against WT and fks mutant Candida albicans, Candida glabrata and Candida tropicalis, the activity of CD101 [MIC90 = 0.06, 0.12 and 0.03 mg/L, respectively (CLSI method values)] was comparable to that of anidulafungin (MIC90 = 0.03, 0.12 and 0.03 mg/L, respectively) and caspofungin (MIC90 = 0.12, 0.25 and 0.12 mg/L, respectively). WT Candida krusei isolates were very susceptible to CD101 (MIC = 0.06 mg/L). CD101 activity (MIC50/90 = 1/2 mg/L) was comparable to that of anidulafungin (MIC50/90 = 2/2 mg/L) against Candida parapsilosis. CD101 (MIC mode = 0.06 mg/L for C. glabrata) was 2- to 4-fold more active against fks hotspot mutants than caspofungin (MIC mode = 0.5 mg/L). CD101 was active against Aspergillus fumigatus, Aspergillus terreus, Aspergillus niger and Aspergillus flavus (MEC90 range = ≤0.008–0.03 mg/L). The essential agreement between CLSI and EUCAST methods for CD101 was 92.0%–100.0% among Candida spp. and 95.0%–100.0% among Aspergillus spp. Conclusions The activity of CD101 is comparable to that of other members of the echinocandin class for the prevention and treatment of serious fungal infections. Similar results for CD101 activity versus Candida and Aspergillus spp. may be obtained with either CLSI or EUCAST BMD methods. PMID:27287236

  20. Laboratory Evaluation of In Situ Chemical Oxidation for Groundwater Remediation, Test Area North, Operable Unit 1-07B, Idaho National Engineering and Environmental Laboratory, Volume Two, Appendices C, D, and E

    SciTech Connect

    Cline, S.R.; Denton, D.L.; Giaquinto, J.M.; McCracken, M.K.; Starr, R.C.

    1999-04-01

    These appendices support the results and discussion of the laboratory work performed to evaluate the feasibility of in situ chemical oxidation for Idaho National Environmental and Engineering Laboratory's (INEEL) Test Area North (TAN) which is contained in ORNL/TM-1371 l/Vol. This volume contains Appendices C-E. Appendix C is a compilation of all recorded data and mathematical calculations made to interpret the data. For the Task 3 and Task 4 work, the spreadsheet column definitions are included immediately before the actual spreadsheet pages and are listed as ''Sample Calculations/Column Definitions'' in the table of contents. Appendix D includes the chronological order in which the experiments were conducted and the final project costs through October 1998. Appendix E is a compilation of the monthly progress reports submitted to INEEL during the course of the project.

  1. Energy Conservation Study on Simplot Potato Processing Plant Heyburn, Idaho, Appendices.

    SciTech Connect

    Seton, Johnson & Odell, Inc.

    1985-03-01

    This group of appendices, B--G, of the ''Simplot Potato Processing Plant Energy Conservation Study'', covers processing equipment, refrigeration equipment, water systems, air conditioning systems and lighting systems. Data on these systems related to cost and energy consumption are given. (JF)

  2. An Evaluation of the Nutrition Services for the Elderly. Volume IV. Appendices.

    ERIC Educational Resources Information Center

    Kirschner Associates, Inc., Albuquerque, NM.

    This document is part of a five-volume nationwide study of Nutrition Services operations and elderly citizens participating in congregate dining and home delivery services authorized by Title III-C of the Older Americans' Act. This volume contains all technical appendices and is intended as a resource document. The Methodology Appendix is included…

  3. Energy Conservation Field Projects. Phase 2: External Evaluation. Document II: Appendices.

    ERIC Educational Resources Information Center

    Stanley Associates, Edmonton (Alberta).

    Provided are appendices which contain supporting documentation related to an external evaluation of the Phase 2: Energy Conservation Field Projects. Objectives of this program were to: test the generalizability of the energy conservations measures outlined in "Guidelines for Conserving Energy in Alberta Schools" and augment these…

  4. Study of short haul high-density V/STOL transportation systems. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Solomon, H. L.

    1972-01-01

    Essential supporting data to the short haul transportation study are presented. The specific appendices are arena characteristics, aerospace transportation analysis computer program, economics, model calibration, STOLport siting and services path selection, STOL schedule definition, tabulated California corridor results, and tabulated Midwest arena results.

  5. Regional assessment of aquifers for thermal-energy storage. Volume 3. Appendices

    SciTech Connect

    Not Available

    1981-06-01

    This volume contains two appendices to the main report. The first lists the aquifers in the 12 geographic regions of the USA and characterizes each as containing sands and gravels or limestones or volcanic rock. The second appendix tabulates the hydrologic characteristics of each aquifer. (LCL)

  6. High efficiency vapor-fed AMTEC system for direct conversion. Appendices for final report

    SciTech Connect

    Anderson, W.G.; Bland, J.J.

    1997-05-23

    This report consists of four appendices for the final report. They are: Appendix A: 700 C Vapor-Fed AMTEC Cell Calculations; Appendix B: 700 C Vapor-Fed AMTEC Cell Parts Drawings; Appendix C: 800 C Vapor-Fed AMTEC Cell Calculations; and Appendix D: 800 C Wick-Pumped AMTEC Cell System Design.

  7. The foundation of the Melbourne Code Appendices: Announcing a new paradigm for tracking nomenclatural decisions

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A new expanded digital resource exists for tracking decisions on all nomenclature proposals potentially contributing to Appendices II-VIII of the International Code of Nomenclature. This system owes its origins to the Smithsonian Institution's Proposals and Disposals website created by Dan Nicolson ...

  8. 50 CFR 23.4 - What are Appendices I, II, and III?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA (CITES) Introduction § 23.4 What are Appendices I, II, and III? Species are listed by the Parties... of Appendix-I, -II, and -III species and their parts, products, and derivatives through a system...

  9. 50 CFR 23.4 - What are Appendices I, II, and III?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA (CITES) Introduction § 23.4 What are Appendices I, II, and III? Species are listed by the Parties... of Appendix-I, -II, and -III species and their parts, products, and derivatives through a system...

  10. 50 CFR 23.4 - What are Appendices I, II, and III?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA (CITES) Introduction § 23.4 What are Appendices I, II, and III? Species are listed by the Parties... of Appendix-I, -II, and -III species and their parts, products, and derivatives through a system...

  11. [Appendiceal abscess in the third gestational trimester of pregnancy, complications pre and postoperatively].

    PubMed

    Cyrkowicz, A; Cibor, Z; Słowińska-Zabówka, M; Kisiel, W; Oleksy, P; Orczyk, K; Bajorek, M; Kwiek, G

    1996-01-01

    Delayed surgical intervention connected with misdiagnosis of preterm labour and urinary tract infection caused in gravida 3 in 34th gestational week appendiceal abscess, septic shock, stillbirth by cesarean section, necessity of hysterectomy, recidivism of multi peritoneal and pleural abscesses. Although the patient was rescued the retrospective pro memoria considerations of our procedure are regarded.

  12. Light Helicopter Family Trade-Off Analysis. Volume 10. Appendices V, W, X, and Z

    DTIC Science & Technology

    2014-01-02

    Data Bnfrtd) REPORT DOCUMENTATION PAGE 1. REPORT NUMBER ACN 69396 2. GOVT ACCESSION NO 4. TITLE (md SubUtU) LIGHT HELICOPTER FAMILY CLHX...APPENDICES V, W, X, AND Z VOLUME X ACN : 69396 Accession For^ "NTIS GRA&I DT1C TAB Unannounced D Justification s By Distribution

  13. No-migration variance petition. Appendices C--J: Volume 5, Revision 1

    SciTech Connect

    Not Available

    1990-03-01

    Volume V contains the appendices for: closure and post-closure plans; RCRA ground water monitoring waver; Waste Isolation Division Quality Program Manual; water quality sampling plan; WIPP Environmental Procedures Manual; sample handling and laboratory procedures; data analysis; and Annual Site Environmental Monitoring Report for the Waste Isolation Pilot Plant.

  14. Stages of change for physical activity and dietary habits in persons with type 2 diabetes included in a mobile health intervention: the Norwegian study in RENEWING HEALTH

    PubMed Central

    Holmen, Heidi; Wahl, Astrid; Torbjørnsen, Astrid; Jenum, Anne Karen; Småstuen, Milada Cvancarova; Ribu, Lis

    2016-01-01

    Objective The aim of this study was to investigate stages of change for physical activity and dietary habits using baseline data from persons with type 2 diabetes included in a mobile health intervention. We examined the associations between stages of change for physical activity change and dietary change, and between stages of change for each behavior and individual characteristics, health-related quality of life, self-management, depressive symptoms, and lifestyle. Research design and methods We examined 151 persons with type 2 diabetes with an glycated hemoglobin (HbA1c) level ≥7.1%, aged ≥18 years at baseline of a randomized controlled trial, before testing a mobile app with or without health counseling. Stages of change were dichotomized into ‘pre-action’ and ‘action’. Self-management was measured using the Health Education Impact Questionnaire (heiQ) where a higher score reflects increased self-management, and health-related quality of life was measured with the Short-Form-36 (SF-36). Logistic regression modeling was performed. Results The median HbA1c level was 7.9% (7.1–12.4), 90% were overweight or obese, and 20% had ≥3 comorbidities. 58% were in the preaction stage for physical activity change and 79% in the preaction stage for dietary change. Higher scores of self-management were associated with an increased chance of being in the action stage for both dietary change and physical activity change. Higher body mass index was associated with an 8% reduced chance of being in the action stage for physical activity change (OR 0.92, 95% CI 0.86 to 0.99). Conclusions Being in the action stage was associated with higher scores of self-management, crucial for type 2 diabetes. Over half of the participants were in the preaction stage for physical activity and dietary change, and many had a high disease burden with comorbidities and overweight. Trial registration number NCT01315756. PMID:27239317

  15. A Comparison of Brunt Criteria, the Non Alcoholic Fatty Liver Disease Activity Score (NAS) & a Proposed NAS-including fibrosis as Valid Diagnostic Scores for NASH

    PubMed Central

    Santiago-Rolón, Amarilys; Purcell, Dagmary; Rosado, Kathia; Toro, Doris H.

    2016-01-01

    Objective Non-alcoholic steatohepatitis (NASH) can result in cirrhosis and end stage liver disease. It is of utmost importance to differentiate NASH from simple steatosis. The aim of this study is to determine the prevalence of NASH in Latino veterans with metabolic syndrome and compare histologic grading using Brunt Criteria, the NAFLD activity score (NAS), and a proposed NAS score including fibrosis. Methods Veterans with metabolic syndrome, hepatic steatosis and elevation of ALT/AST who underwent a liver biopsy from 2004-2010 were included in this study. Biopsies were evaluated by a single blinded Hepatopathologist. Steatosis, lobular inflammation, ballooning and fibrosis were graded per specimen. Each biopsy was evaluated using Brunt criteria, NAS and NAS plus fibrosis. Results Sixty patients were included in this study, 88.3% men with a mean age of 50.4 (± 12.8). 50.0% met criteria for NASH according to the Brunt system. When classifying biopsies using NAS, only 30.0% (18/60) had a score ≥5, while when adding fibrosis, the number of patients with a score ≥5 increased to 33 (55.0%). When evaluating the predictive ability of the two scoring systems, we found that NAS including fibrosis had a higher sensitivity than NAS (86.7% vs. 40.0%) and a lower specificity (76.7% vs. 80.0%). Conclusion In our population with metabolic syndrome and altered liver function tests, about 50-55% had steatohepatitis. There were significant differences between the scoring systems. When using NAS-plus-fibrosis more patients were recognized and the sensitivity increased. Further validation studies are required to evaluate this proposed NAS scoring System. PMID:26602577

  16. Safety analysis report for the use of hazardous production materials in photovoltaic applications at the National Renewable Energy Laboratory. Volume 2, Appendices

    SciTech Connect

    Crandall, R.S.; Nelson, B.P.; Moskowitz, P.D.; Fthenakis, V.M.

    1992-07-01

    To ensure the continued safety of SERI`s employees, the community, and the environment, NREL commissioned an internal audit of its photovoltaic operations that used hazardous production materials (HPMS). As a result of this audit, NREL management voluntarily suspended all operations using toxic and/or pyrophoric gases. This suspension affected seven laboratories and ten individual deposition systems. These activities are located in Building 16, which has a permitted occupancy of Group B, Division 2 (B-2). NREL management decided to do the following. (1) Exclude from this SAR all operations which conformed, or could easily be made to conform, to B-2 Occupancy requirements. (2) Include in this SAR all operations that could be made to conform to B-2 Occupancy requirements with special administrative and engineering controls. (3) Move all operations that could not practically be made to conform to B-2 occupancy requirements to alternate locations. In addition to the layered set of administrative and engineering controls set forth in this SAR, a semiquantitative risk analysis was performed on 30 various accident scenarios. Twelve presented only routine risks, while 18 presented low risks. Considering the demonstrated safe operating history of NREL in general and these systems specifically, the nature of the risks identified, and the layered set of administrative and engineering controls, it is clear that this facility falls within the DOE Low Hazard Class. Each operation can restart only after it has passed an Operational Readiness Review, comparing it to the requirements of this SAR, while subsequent safety inspections will ensure future compliance. This document contains the appendices to the NREL safety analysis report.

  17. Synopsis of Cathode #4 Activation

    SciTech Connect

    Kwan, Joe; Ekdahl, C.; Harrison, J.; Kwan, J.; Leitner, M.; McCruistian, T.; Mitchell, R.; Prichard, B.; Roy, P.

    2006-05-26

    The purpose of this report is to describe the activation of the fourth cathode installed in the DARHT-II Injector. Appendices have been used so that an extensive amount of data could be included without danger of obscuring important information contained in the body of the report. The cathode was a 612 M type cathode purchased from Spectra-Mat. Section II describes the handling and installation of the cathode. Section III is a narrative of the activation based on information located in the Control Room Log Book supplemented with time plots of pertinent operating parameters. Activation of the cathode was performed in accordance with the procedure listed in Appendix A. The following sections provide more details on the total pressure and constituent partial pressures in the vacuum vessel, cathode heater power/filament current, and cathode temperature.

  18. Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

    PubMed Central

    Brimson, James M.; Brimson, Sirikalaya J.; Brimson, Christopher A.; Rakkhitawatthana, Varaporn; Tencomnao, Tewin

    2012-01-01

    The Herb Rhinacanthus nasutus (L.) Kurz, which is native to Thailand and Southeast Asia, has become known for its antioxidant properties. Neuronal loss in a number of diseases including Alzheimer’s disease is thought to result, in part, from oxidative stress. Glutamate causes cell death in the mouse hippocampal cell line, HT-22, by unbalancing redox homeostasis, brought about by a reduction in glutathione levels, and amyloid-β has been shown to induce reactive oxygen species (ROS) production. Here in, we show that ethanol extracts of R. nasutus leaf and root are capable of dose dependently attenuating the neuron cell death caused by both glutamate and amyloid-β treatment. We used free radical scavenging assays to measure the extracts antioxidant activities and as well as quantifying phenolic, flavonoid and sterol content. Molecules found in R. nasutus, lupeol, stigmasterol and β-sitosterol are protective against glutamate toxicity. PMID:22606031

  19. Endoloop versus endostapler closure of the appendiceal stump in pediatric laparoscopic appendectomy

    PubMed Central

    Safavi, Arash; Langer, Monica; Skarsgard, Erik D.

    2012-01-01

    Background There is little information available to inform choice of technique for appendiceal stump control in pediatric laparoscopic appendectomy (LA). We compared complications (stump leak, intra-abdominal abscess formation [IAA], surgical site infection [SSI]) in children undergoing LA for perforated (PA) and nonperforated appendicitis (NPA) by technique of appendiceal stump control. Methods All children who underwent LA for confirmed acute appendicitis between 2006 and 2009 were reviewed. Choice of stump control (endoloop [EL] or endostapler [ES]) was determined by surgeon preference. Interactions between stump closure techniques and other potential confounders (intra-abdominal drain, irrigation, different antibiotic regimens) were explored using a logistic regression model. Results Of 242 patients undergoing LA, 57 (23.6%) had PA. In the PA group the appendiceal stump was closed with EL in 47 (82.5%) patients, while in the NPA group EL was used in 161 (87%) patients. Among PA patients, IAA was more common in the ES than the EL group (5 of 10 [50%] v. 6 of 47 [12.7%]). There was no significant difference in rates of SSI. Among NPA patients, there were no differences in rates of IAA or SSI. There were no stump leaks in either group. Logistic regression analysis confirmed the predictive effect of ES use on IAA formation in PA (adjusted odds ratio 7.09; 95% confidence interval 1.08–46.13; p = 0.042). Conclusion Our data suggest that in most cases of PA, the appendiceal stump can be safely controlled with EL. Within the PA group, the higher rates of IAA seen in ES patients may be attributable to the quality of the appendiceal stump rather than the technique of closure. PMID:22269300

  20. Foothills Parkway Section 8B Final Environmental Report, Volume 2, Appendices A-C

    SciTech Connect

    Blasing, T.J.; Cada, G.F.; Carer, M.; Chin, S.M.; Dickerman, J.A.; Etnier, D.A.; Gibson, R.; Harvey, M.; Hatcher, B.; Lietzske, D.; Mann, L.K.; Mulholland, P.J.; Petrich, C.H.; Pounds, L.; Ranney, J.; Reed, R.M.; Ryan, P.F.; Schweitzer, M.; Smith, D.; Thomason, P.; Wade, M.C.

    1999-07-01

    In 1994, Oak Ridge National Laboratory (ORNL) was tasked by the National Park Service (NPS) to prepare an Environmental Report (ER) for Section 8B of the Foothills Parkway in the Great Smoky Mountains National Park (GSMNP). Section 8B represents 27.7 km (14.2 miles) of a total of 115 km (72 miles) of the planned Foothills Parkway and would connect the Cosby community on the east to the incorporated town of Pittman Center to the west. The major deliverables for the project are listed. From August 1995 through October 1996, NW, GSMNP, and ORNL staff interacted with Federal Highway Administration staff to develop a conceptual design plan for Section 8B with the intent of protecting critical resources identified during the ER process to the extent possible. In addition, ORNL arranged for bioengineering experts to discuss techniques that might be employed on Section 8B with NPS, GSMNP, and ORNL staff during September 1996. For the purposes of this EN there are two basic alternatives under consideration: (1) a build alternative and (2) a no-build alternative. Within the build alternative are a number of options including constructing Section 8B with no interchanges, constricting Section 8B with an interchange at SR 416 or U.S. 321, constructing Section 8B with a spur road on Webb Mountain, and considering operation of Section 8B both before and after the operation of Section 8C. The no-build alternative is considered the no-action alternative and is not to construct Section 8B. This volume of the ER, which consists of Appendices A, B, and C, assesses the potential geologic impacts of the proposed Section 8B construction, presents the results of the Section 8B soil survey, and describes the water quality studies and analyses performed for the ER. The following summary sections provide information for geology, soils, and water quality.

  1. Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation including Citrus bergamia, in subjects with moderate cardiometabolic risk factors.

    PubMed

    Babish, John G; Dahlberg, Clinton J; Ou, Joseph J; Keller, William J; Gao, Wei; Kaadige, Mohan R; Brabazon, Holly; Lamb, Joseph; Soudah, Hani C; Kou, Xiaolan; Zhang, Zhe; Pacioretty, Linda M; Tripp, Matthew L

    2016-12-01

    We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen. Statistically significant changes were noted in total cholesterol (-7.3%), LDL-cholesterol (-10%), non-HDL cholesterol (-7.1%), cholesterol/HDL (-26%), and apolipoprotein B (-2.8%). A post hoc analysis of 8 subjects with HbA1c > 5.4 and HOMA-IR score > 2 or elevated triglycerides revealed additional statistically significant changes in addition to those previously observed in all subjects including triglycerides (-27%), oxLDL (-19%), LDL/HDL (-25%), triglycerides/HDL (-27%), oxLDL/HDL (-25%), and PAI-1 (-37%). A follow-up case report of a 70-year-old female patient, nonresponsive to statin therapy and placed on F105 daily, demonstrated improved cardiometabolic variables over 12 weeks similar to the subgroup. In summary, F105 was clinically well-tolerated and effective for ameliorating dyslipidemia in subjects with moderate cardiometabolic risk factors, particularly in the individuals with HbA1c > 5.4%.

  2. Establishment of reference intervals for kaolin-activated thromboelastography in dogs including an assessment of the effects of sex and anticoagulant use.

    PubMed

    Bauer, Natali; Eralp, Oya; Moritz, Andreas

    2009-09-01

    Tissue factor (TF)- and kaolin-activated thromboelastography (TEG) have been performed in a small number of healthy dogs, but reference intervals have not been assessed in a larger number of dogs. The goal of the current study was to establish reference intervals and assess intra-assay repeatability for kaolin-activated TEG in dogs. Additionally, the impact of sex and the influence of anticoagulant (native blood vs. recalcified citrate anticoagulated blood) were evaluated. Thromboelastography analyses were performed in 56 healthy dogs including German Shepherd Dogs (n = 19), Beagles (n = 15), and others (n = 22). Median age was 2 years (range: 1-6 years) and sex was evenly distributed (31 males and 25 females). To establish reference intervals, citrated whole-blood samples were collected, and TEG was performed 1 hr after sampling. Five TEG variables (R = reaction time; K = clot formation time; alpha = angle alpha; MA = maximal amplitude; G-value reflecting clot stability) were evaluated, and reference intervals were defined as the mean +/- 1.96-fold standard deviation. Intra-assay repeatability was assessed by calculating the pooled variance estimate in duplicate measurements of 6 healthy dogs. The effect of anticoagulant was assessed in 17 specimens. Reference intervals were as follows: R = 1.8-8.6 min; angle alpha = 36.9-74.6 degrees; K = 1.3-5.7 min; MA = 42.9-67.9 mm, and G = 3.2-9.6 Kdyn/cm(2). Coefficients of variation for R, K, angle alpha, MA, and G were 7.6%, 17.7%, 7.4%, 2.9%, and 6.6%, respectively. There was no significant impact of sex or anticoagulant on results. Interindividual variation was higher in native samples than in citrated whole blood. A limitation of the current study was that most of the samples were obtained from Beagles and German Shepherd Dogs. This study provides useful reference intervals for kaolin-activated TEG.

  3. Analysis of the permitting processes associated with exploration of Federal OCS leases. Final report. Volume II. Appendices

    SciTech Connect

    Not Available

    1980-11-01

    Under contract to the Office of Leasing Policy Development (LPDO), Jack Faucett Associates is currently undertaking the description and analysis of the Outer Continental Shelf (OCS) regulatory process to determine the nature of time delays that affect OCS production of oil and gas. This report represents the results of the first phase of research under this contract, the description and analysis of regulatory activity associated with exploration activities on the Federal OCS. Volume 1 contains the following three sections: (1) study results; (2) Federal regulatory activities during exploration of Federal OCS leases which involved the US Geological Survey, Environmental Protection Agency, US Coast Guard, Corps of Engineers, and National Ocean and Atmospheric Administration; and (3) state regulatory activities during exploration of Federal OCS leases of Alaska, California, Louisiana, Massachusetts, New Jersey, North Carolina and Texas. Volume II contains appendices of US Geological Survey, Environmental Protection Agency, Coast Guard, Corps of Engineers, the Coastal Zone Management Act, and Alaska. The major causes of delay in the regulatory process governing exploration was summarized in four broad categories: (1) the long and tedious process associated with the Environmental Protection Agency's implementation of the National Pollutant Discharge Elimination System Permit; (2) thelack of mandated time periods for the completion of individual activities in the permitting process; (3) the lack of overall coordination of OCS exploratory regulation; and (4) the inexperience of states, the Federal government and industry relating to the appropriate level of regulation for first-time lease sale areas.

  4. PREFACE: 9th International Fröhlich's Symposium: Electrodynamic Activity of Living Cells (Including Microtubule Coherent Modes and Cancer Cell Physics)

    NASA Astrophysics Data System (ADS)

    Cifra, Michal; Pokorný, Jirí; Kucera, Ondrej

    2011-12-01

    This volume contains papers presented at the International Fröhlich's Symposium entitled 'Electrodynamic Activity of Living Cells' (1-3 July 2011, Prague, Czech Republic). The Symposium was the 9th meeting devoted to physical processes in living matter organized in Prague since 1987. The hypothesis of oscillation systems in living cells featured by non-linear interaction between elastic and electrical polarization fields, non-linear interactions between the system and the heat bath leading to energy downconversion along the frequency scale, energy condensation in the lowest frequency mode and creation of a coherent state was formulated by H Fröhlich, founder of the theory of dielectric materials. He assumed that biological activity is based not only on biochemical but also on biophysical mechanisms and that their disturbances form basic links along the cancer transformation pathway. Fröhlich outlined general ideas of non-linear physical processes in biological systems. The downconversion and the elastic-polarization interactions should be connected in a unified theory and the solution based on comprehensive non-linear characteristics. Biochemical and genetic research of biological systems are highly developed and have disclosed a variety of cellular and subcellular structures, chemical reactions, molecular information transfer, and genetic code sequences - including their pathological development. Nevertheless, the cancer problem is still a big challenge. Warburg's discovery of suppressed oxidative metabolism in mitochondria in cancer cells suggested the essential role of physical mechanisms (but his discovery has remained without impact on cancer research and on the study of physical properties of biological systems for a long time). Mitochondria, the power plants of the cell, have several areas of activity-oxidative energy production is connected with the formation of a strong static electric field around them, water ordering, and liberation of non

  5. U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)

    USGS Publications Warehouse

    Tony K. Meunier Edited by Williams, Richard S.; Ferrigno, Jane G.

    2007-01-01

    international) programs in biology, geology, geophysics, hydrology, and mapping. Therefore, the USGS was the obvious choice for these tasks, because it already had a professional staff of experienced mapmakers, scientists, and program managers with the foresight, dedication, and understanding of the need for accurate maps to support the science programs in Antarctica when asked to do so by the U.S. National Academy of Sciences. Public Laws 85-743 and 87-626, signed in August 1958, and in September 1962, respectively, authorized the Secretary, U.S. Department of the Interior, through the USGS, to support mapping and scientific work in Antarctica (Meunier, 1979 [2007], appendix A). Open-File Report 2006-1116 includes scanned facsimiles of postal cachets. It has become an international practice to create postal cachets to commemorate special events and projects in Antarctica. A cachet is defined as a seal or commemorative design printed or stamped on an envelope to mark a philatelic or special event. The inked impression illustrates to the scientist, historian, stamp collector, and general public the multidisciplinary science projects staffed by USGS and collaborating scientists during the field season. Since 1960, philatelic cachets have been created by team members for each USGS field season and, in most cases, these cachets depict the specific geographic areas and field season program objectives. The cachets become a convenient documentation of the people, projects, and geographic places of interest for that year. Because the cachets are representative of USGS activities, each year's cachet is included as a digital facsimile in that year's Open-File Report. In the 1980s, multiple USGS cachets were prepared each year, one for use by the winter team at Amundsen-Scott South Pole Station and the other for the project work areas of the austral summer field season programs.

  6. In vitro activity of ceftazidime/avibactam against Gram-negative pathogens isolated from pneumonia in hospitalised patients, including ventilated patients.

    PubMed

    Flamm, Robert K; Nichols, Wright W; Sader, Helio S; Farrell, David J; Jones, Ronald N

    2016-03-01

    The activities of the novel β-lactam/non-β-lactam β-lactamase inhibitor combination ceftazidime/avibactam and comparators were evaluated against isolates from pneumonia in hospitalised patients including ventilated patients (PHP, pneumonia not designated as VABP; VABP, pneumonia in ventilated patients). Isolates were from the European-Mediterranean region (EuM), China and the USA collected in the SENTRY Antimicrobial Surveillance Program between 2009 and 2011 inclusive. A total of 2393 organisms from PHP were from the EuM, 888 from China and 3213 from the USA; from VABP patients there were 918, 97 and 692 organisms collected, respectively. Among Enterobacteriaceae from PHP, ceftazidime/avibactam MIC90 values against Escherichia coli ranged from 0.25-0.5mg/L and Klebsiella spp. MIC90 values were 0.5mg/L in each region. Among VABP isolates, MIC90 values for ceftazidime/avibactam against E. coli were 0.25mg/L; for Klebsiella spp. from VABP patients, MIC90 values were similar to those obtained against PHP isolates. The MIC of ceftazidime/avibactam was ≤8mg/L against 92-96% of Pseudomonas aeruginosa isolated from PHP patients. Isolates of P. aeruginosa from VABP patients were of lower susceptibility to all antibacterial agents (e.g. depending on region, meropenem susceptibilities were 51.2-69.4% in contrast to 68.3-76.7% among PHP patients). However, ceftazidime/avibactam inhibited 79.2-95.4% of VABP isolates at an MIC of ≤8mg/L. Acinetobacter spp. were resistant to many agents and only rates of susceptibility to colistin were >90% across all regions both for PHP and VABP isolates. Ceftazidime/avibactam was generally active against a high proportion of isolates resistant to ceftazidime from PHP and VAPB patients.

  7. The 1992 catalog of space science and applications education programs and activities

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This catalog provides information on current, ongoing and pilot programs conducted at precollege through postdoctoral levels which are primarily funded or managed by the Office of Space Science Applications (OSSA). The directory of programs section includes teacher and faculty preparation and enhancement, student enrichment opportunities, student research opportunities, postdoctoral and advanced research opportunities, initiatives to strengthen educational institution involvement in research and initiatives to strengthen research community involvement in education. The Educational Products appendices include tabular data of OSSA activities, NASA Spacelink, NASA education satellites videoconferences, the Teacher Resource Center Network, and a form for requesting further information.

  8. Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition.

    PubMed

    Gupta, Mamta; Gupta, Shiv Kumar; Hoffman, Barbara; Liebermann, Dan A

    2006-06-30

    Gadd45a, Gadd45b, and Gadd45g (Gadd45/MyD118/CR6) are genes that are rapidly induced by genotoxic stress and have been implicated in genotoxic stress-induced responses, notably in apoptosis. Recently, using myeloid-enriched bone marrow (BM) cells obtained from wild-type (WT), Gadd45a-deficient, and Gadd45b-deficient mice, we have shown that in hematopoietic cells Gadd45a and Gadd45b play a survival function to protect hematopoietic cells from DNA-damaging agents, including ultra violet (UV)-induced apoptosis. The present study was undertaken to decipher the molecular paths that mediate the survival functions of Gadd45a and Gadd45b against genotoxic stress induced by UV radiation. It is shown that in hematopoietic cells exposed to UV radiation Gaddd45a and Gadd45b cooperate to promote cell survival via two distinct signaling pathways involving activation of the GADD45a-p38-NF-kappaB-mediated survival pathway and GADD45b-mediated inhibition of the stress response MKK4-JNK pathway.

  9. SWEIS annual review - CY2002 : a comparison of CY2002 operations to projections included in the site-wide environmental impact statement for continued operation of Sandia National Laboratories/New Mexico.

    SciTech Connect

    Bayliss, Linda Sue; White, Brenda Bailey; Guerrero, Joseph Vincent; Catechis, Christopher Spyros

    2003-10-01

    The SNL/NM CY2002 SWEIS Annual Review discusses changes in facilities and facility operations that have occurred in selected and notable facilities since source data were collected for the SNL/NM SWEIS (DOE/EIS-0281). The following information is presented: {sm_bullet} An updated overview of SNL/NM selected and notable facilities and infrastructure capabilities. {sm_bullet} An overview of SNL/NM environment, safety, and health programs, including summaries of the purpose, operations, activities, hazards, and hazard controls at relevant facilities and risk management methods for SNL/NM. {sm_bullet} Updated base year activities data, together with related inventories, material consumption, emissions, waste, and resource consumption. {sm_bullet} Appendices summarizing activities and related hazards at SNL/NM individual special, general, and highbay laboratories, and chemical purchases.

  10. Kinetics of Hydrogen Radical Reactions with Toluene Including Chemical Activation Theory Employing System-Specific Quantum RRK Theory Calibrated by Variational Transition State Theory.

    PubMed

    Bao, Junwei Lucas; Zheng, Jingjing; Truhlar, Donald G

    2016-03-02

    Pressure-dependent reactions are ubiquitous in combustion and atmospheric chemistry. We employ a new calibration procedure for quantum Rice-Ramsperger-Kassel (QRRK) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff effect of a radical association with an aromatic ring. The new theoretical framework is applied to the reaction of H with toluene, which is a prototypical reaction in the combustion chemistry of aromatic hydrocarbons present in most fuels. Both the hydrogen abstraction reactions and the hydrogen addition reactions are calculated. Our system-specific (SS) QRRK approach is adjusted with SS parameters to agree with multistructural canonical variational transition state theory with multidimensional tunneling (MS-CVT/SCT) at the high-pressure limit. The new method avoids the need for the usual empirical estimations of the QRRK parameters, and it eliminates the need for variational transition state theory calculations as a function of energy, although in this first application we do validate the falloff curves by comparing SS-QRRK results without tunneling to multistructural microcanonical variational transition state theory (MS-μVT) rate constants without tunneling. At low temperatures, the two approaches agree well with each other, but at high temperatures, SS-QRRK tends to overestimate falloff slightly. We also show that the variational effect is important in computing the energy-resolved rate constants. Multiple-structure anharmonicity, torsional-potential anharmonicity, and high-frequency-mode vibrational anharmonicity are all included in the rate computations, and torsional anharmonicity effects on the density of states are investigated. Branching fractions, which are both temperature- and pressure-dependent (and for which only limited data is available from experiment), are predicted as a function of pressure.

  11. Limited, local, extracolonic spread of mucinous appendiceal adenocarcinoma after perforation with formation of a malignant appendix-to-sigmoid fistula: Case report and literature review

    PubMed Central

    Hakim, Seifeldin; Amin, Mitual; Cappell, Mitchell S

    2016-01-01

    A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum (with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel. Gross and microscopic pathologic examination revealed an appendix-to-sigmoid malignant fistula secondary to perforation of mucinous adenocarcinoma of the appendix with minimal local spread (stage T4). However, the surgical margins were clear, all 13 resected lymph nodes were cancer-free, and pseudomyxoma peritonei or peritoneal implants were not present. The patient did well during 1 year of follow-up with no clinical or radiologic evidence of local recurrence, metastases, or pseudomyxoma peritonei despite presenting with extensive stage T4 cancer that was debulked without administering chemotherapy, and despite presenting with malignant appendiceal perforation. This case illustrates the non-aggressive biologic behavior of this low-grade malignancy. The fistula may have prevented free spillage of cancerous cells and consequent distant metastases by containing the appendiceal contents largely within the colon. PMID:27784975

  12. Limited, local, extracolonic spread of mucinous appendiceal adenocarcinoma after perforation with formation of a malignant appendix-to-sigmoid fistula: Case report and literature review.

    PubMed

    Hakim, Seifeldin; Amin, Mitual; Cappell, Mitchell S

    2016-10-14

    A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum (with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel. Gross and microscopic pathologic examination revealed an appendix-to-sigmoid malignant fistula secondary to perforation of mucinous adenocarcinoma of the appendix with minimal local spread (stage T4). However, the surgical margins were clear, all 13 resected lymph nodes were cancer-free, and pseudomyxoma peritonei or peritoneal implants were not present. The patient did well during 1 year of follow-up with no clinical or radiologic evidence of local recurrence, metastases, or pseudomyxoma peritonei despite presenting with extensive stage T4 cancer that was debulked without administering chemotherapy, and despite presenting with malignant appendiceal perforation. This case illustrates the non-aggressive biologic behavior of this low-grade malignancy. The fistula may have prevented free spillage of cancerous cells and consequent distant metastases by containing the appendiceal contents largely within the colon.

  13. Recommendations for a Department of Energy Nuclear Energy R and D Agenda Volume 2 Appendices

    SciTech Connect

    1997-12-01

    The current US nuclear energy policy is primarily formulated as part of the nation`s overall energy policy. In addition, nuclear energy policy is impacted by other US policies, such as those for defense and environment, and by international obligations through their effects on nuclear weapons dismantlement and stewardship, continued reliance on space and naval nuclear power sources, defense waste cleanup, and on nuclear nonproliferation. This volume is composed of the following appendices: Appendix 1--Objectives of the Federal Government Nuclear Energy Related Policies and Research and Development Programs; Appendix 2--Nuclear Energy and Related R and D in the US; Appendix 3--Summary of Issues That Drive Nuclear Energy Research and Development; Appendix 4: Options for Policy and Research and Development; Appendix 5--Pros and Cons of Objectives and Options; and Appendices 6--Recommendations.

  14. Assessment of the Fishery Improvement Opportunities on the Pend Oreille River, Appendices, 1990 Annual Report.

    SciTech Connect

    Ashe, Becky L.; Lillengreen, Kelly L.; Vella, John J.

    1991-03-01

    This report is a compilation of the seven appendices to DOE/BP/39339--4 the annual report for FY 1990. These appendices contain the supporting numerical data for the study. The purpose of this study was to assess the fishery improvement opportunities on the Box Canyon portion of the Pend Oreilla River. This three year study was initiated as part of the Northwest Power Planning Council's 1987 Columbia River Basin Fish and Wildlife Program. This report contains the findings of the third and final year of the study. The objectives of the third year of the study were to determine the relative abundance of each species in the river and sloughs; the population levels in five selected tributaries and, if possible, for fish in the river and sloughs; each species growth rate, feeding habits, abundance of preferred prey, and migration patterns; and the seasonal movement patterns and habitat utilization of largemouth bass.

  15. Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report

    SciTech Connect

    1995-01-01

    This large document provides a catalog of the location of large numbers of reports pertaining to the charge of the Presidential Advisory Committee on Human Radiation Research and is arranged as a series of appendices. Titles of the appendices are Appendix A- Records at the Washington National Records Center Reviewed in Whole or Part by DoD Personnel or Advisory Committee Staff; Appendix B- Brief Descriptions of Records Accessions in the Advisory Committee on Human Radiation Experiments (ACHRE) Research Document Collection; Appendix C- Bibliography of Secondary Sources Used by ACHRE; Appendix D- Brief Descriptions of Human Radiation Experiments Identified by ACHRE, and Indexes; Appendix E- Documents Cited in the ACHRE Final Report and other Separately Described Materials from the ACHRE Document Collection; Appendix F- Schedule of Advisory Committee Meetings and Meeting Documentation; and Appendix G- Technology Note.

  16. Interface bonding of shotcrete reinforced brick masonry assemblages. Volume 2: Appendices

    NASA Astrophysics Data System (ADS)

    Robinson, D. W.; Kahn, L. F.

    1982-09-01

    The first of four appendices contains interviews with local masonry experts. It is reported that when stucco is applied to masonry walls, an increased resistance to lateral and implane forces results. The dangers of a solfate attack on brick masonry are examined, and it is pointed out that exposure to sulfate attack for 50 to 100 years can destroy the physical strength of a cement product. Distinctions are drawn between large core, small core, and double row core brick, and it is noted that the predominate brick used is the large core. The other appendices contain design, construction, and material properties for 46 specimens, a generalized finite element analysis, and plots for four specimens.

  17. An appendiceal neoplastic lesion: Case report and implications for colonoscopic screening and surveillance

    PubMed Central

    Freeman, Hugh J; Webber, Douglas L; Meneghetti, Adam T

    2009-01-01

    A 65-year-old man with a history of previously resected colonic adenomas had an apparent cecal lesion detected during colonoscopy. The polyp proved to be a tubulovillous adenoma with high-grade dysplasia involving most of the body of the appendix along with the base of the cecum. The appendiceal mucosa is biologically similar to the colonic mucosa, yet remains relatively ‘hidden’ in screening and surveillance studies, which suggests important implications for evolving detection strategies in the follow-up of patients with a previous colon polyp or cancer resections. Although endoscopic removal of the appendix has been reported, treatment of these localized appendiceal lesions requires a wide surgical excision. PMID:19440570

  18. Radiological performance assessment for the E-Area Vaults Disposal Facility. Appendices A through M

    SciTech Connect

    Cook, J.R.

    1994-04-15

    These document contains appendices A-M for the performance assessment. They are A: details of models and assumptions, B: computer codes, C: data tabulation, D: geochemical interactions, E: hydrogeology of the Savannah River Site, F: software QA plans, G: completeness review guide, H: performance assessment peer review panel recommendations, I: suspect soil performance analysis, J: sensitivity/uncertainty analysis, K: vault degradation study, L: description of naval reactor waste disposal, M: porflow input file. (GHH)

  19. Report to Congress on the Indemnification of Contractors Performing Environmental Restoration. Appendices

    DTIC Science & Technology

    1994-01-07

    Department of Defense rTIC To’ T Report to Congress on the Indemnification of Contractors Performing Environmental Restoration Appendices Qffice of...Defense for Environment, recognized this point in testimony before the House Armed Services Committee’s Defense Environmental Restoration Panel. He...officer. FAR S 31.205-15. -34- 0 5. Environmental Restoration Management Contrac- tor. Recently, DOE established a new category of envi- ronmental

  20. Comparative Performance of High Efficiency Ship Propulsion Systems for Destroyer Hull Types. Volume 2. Appendices

    DTIC Science & Technology

    1974-12-06

    Best Available Copy ., AD-A007 341 COMPARATIVE PERFORMANCE OF HIGH EFFICIENCY SHIP PROPULSION SYSTEMS FOR DESTROYER HULL...PERFORMANCE OF HIGH EFFICIENCY SHIP PROPULSION SYSTEMS FOR DESTROYER HULL TYPES VOLUME II APPENDICES By Alan J. Stev/crt 6 December 1974 Approved...of the comparative performance of high eflic.icncy ship propulsion systems, four arrangement drawings have been prepared. Each drawing shows the

  1. Technology, safety and costs of decommissioning a reference boiling water reactor power station. Appendices. Volume 2

    SciTech Connect

    Oak, H.D.; Holter, G.M.; Kennedy, W.E. Jr.; Konzek, G.J.

    1980-06-01

    Appendices are presented concerning the evaluations of decommissioning financing alternatives; reference site description; reference BWR facility description; radiation dose rate and concrete surface contamination data; radionuclide inventories; public radiation dose models and calculated maximum annual doses; decommissioning methods; generic decommissioning information; immediate dismantlement details; passive safe storage, continuing care, and deferred dismantlement details; entombment details; demolition and site restoration details; cost estimating bases; public radiological safety assessment details; and details of alternate study bases.

  2. Gallium scintigraphy demonstration of an appendiceal mucocele: a proposed mechanism of uptake

    SciTech Connect

    Alpert, L.; Friedman, R.

    1981-08-01

    An appendiceal mucocele demonstrated intense early avidity for Ga-67, despite the lack of inflammatory cells to account for the uptake. It is proposed that the acid mucopolysaccharide component of the mucus within the lumen and lining cells accounted for the uptake of the gallium ion, in a similar manner to the uptake of its analogue, the ferric ion, as demonstrated by intense staining of mucus by the colloidal iron technique.

  3. Automating the Exchange of Military Personnel Data Among Selected Army Organizations. Volume II. Appendices,

    DTIC Science & Technology

    1981-06-30

    APPENDICES VOLUME II Presented to the Army Institute for Research in Management Information & Computer Systems (AIRMICS) Contract No. DAK 70-79-0087 Task...Overview". The Accounting Review. Volume 53. Number 2. April 1978. pages 389-401. Georgia Tech Call Number: HF 5601 .A6 v.53. 55. Lau , Amy Hing-Ling and... Lau , Hon-Shing. "Some Proposed Approaches for Writing Off Capaitalized Human Resource Assets". Journal of Accounting Research. Volume 16. Number 1

  4. Appendiceal stump closure by metal endoclip in the management of complicated acute appendicitis

    PubMed Central

    2013-01-01

    Background Closure of appendicular stump has been performed in different ways; however, the use of the metal endoclip in complicated grades of acute appendicitis, has not been evaluated yet in a prospective way. Objective To establish the effectiveness of appendiceal stump closure by metal endoclip for complicated appendicitis. Method From January 2009 to January 2011 were evaluated 131 consecutive patients who underwent a laparoscopic appendectomy for complicated acute appendicitis. From those, 118 underwent appendiceal stump closure by metal endoclip. The patient’s age ranged from 12 to 75 years old (31.7 ± 13.3) and 52.7% were male. Complicated appendicitis refers to gangrenous and/or perforated appendix, which may lead to abscess formation and degrees of peritonitis. The outcomes viability, operative time, infection complication, operative complications, and conversion rate were chosen to evaluate the procedure. Results The appendiceal stump closure by metal endoclip was used in 90% of cases. The presence of appendix base necrosis was the most important factor involved in failure of the procedure. Laparoscopic knot (1.5%), laparoscopic endo-suture (3.8%) and video assisted laparotomy (4.7%) were the alternatives used in difficult cases. The mean operative time was (67.54 ± 28.13 minutes). The wound and intra-abdominal infection rates were 2.54% and 5.08%, respectively. There were no operative complications and the conversion rate was 0.85%. Conclusion The appendiceal stump closure by metal endoclip, in complicated grades of acute appendicitis, is a safe and effective procedure. In patients with appendix base necrosis it should be avoided in favor of other alternatives. PMID:24047531

  5. SAMeDL: Technical Report and Appendices A, B, and G

    DTIC Science & Technology

    1992-09-15

    MANAGEMENT INFORMATION, COMMUNICATIONS, AND COMPUTER SCIENCES SAMeDL: Technical Report and Appendices A, B, and G ASQB-GI-92-015 September 1992 DTIC 1, A...Research in Management Information, Communications, and Computer Sciences (AIRMICS), the RDTE organization of the U. S. Army Information Systems...Institute for Research in Management Information, Comnunication and Co=puter Science (AIRMICS) 115 O’Keefe Building Atlanta, GA 30332-0800 Contract No

  6. Review of technology for Arctic offshore oil and gas recovery. Appendices

    SciTech Connect

    Sackinger, W. M.

    1980-06-06

    This volume contains appendices of the following: US Geological Survey Arctic operating orders, 1979; Det Noske Vertas', rules for the design, construction and inspection of offshore technology, 1977; Alaska Oil and Gas Association, industry research projects, March 1980; Arctic Petroleum Operator's Association, industry research projects, January 1980; selected additional Arctic offshore bibliography on sea ice, icebreakers, Arctic seafloor conditions, ice-structures, frost heave and structure icing.

  7. Life prediction methodology for ceramic components of advanced heat engines. Phase 1: Volume 2, Appendices

    SciTech Connect

    1995-03-01

    This volume presents the following appendices: ceramic test specimen drawings and schematics, mixed-mode and biaxial stress fracture of structural ceramics for advanced vehicular heat engines (U. Utah), mode I/mode II fracture toughness and tension/torsion fracture strength of NT154 Si nitride (Brown U.), summary of strength test results and fractography, fractography photographs, derivations of statistical models, Weibull strength plots for fast fracture test specimens, and size functions.

  8. Effects of Lifestyle Interventions That Include a Physical Activity Component in Class II and III Obese Individuals: A Systematic Review and Meta-Analysis

    PubMed Central

    Baillot, Aurélie; Romain, Ahmed J.; Boisvert-Vigneault, Katherine; Audet, Mélisa; Baillargeon, Jean Patrice; Dionne, Isabelle J.; Valiquette, Louis; Chakra, Claire Nour Abou; Avignon, Antoine; Langlois, Marie-France

    2015-01-01

    Background In class II and III obese individuals, lifestyle intervention is the first step to achieve weight loss and treat obesity-related comorbidities before considering bariatric surgery. A systematic review, meta-analysis, and meta-regression were performed to assess the impact of lifestyle interventions incorporating a physical activity (PA) component on health outcomes of class II and III obese individuals. Methods An electronic search was conducted in 4 databases (Medline, Scopus, CINAHL and Sportdiscus). Two independent investigators selected original studies assessing the impact of lifestyle interventions with PA components on anthropometric parameters, cardiometabolic risk factors (fat mass, blood pressure, lipid and glucose metabolism), behaviour modification (PA and nutritional changes), and quality of life in adults with body mass index (BMI) ≥ 35 kg/m2. Estimates were pooled using a random-effect model (DerSimonian and Laird method). Heterogeneity between studies was assessed by the Cochran’s chi-square test and quantified through an estimation of the I². Results Of the 3,170 identified articles, 56 met our eligibility criteria, with a large majority of uncontrolled studies (80%). The meta-analysis based on uncontrolled studies showed significant heterogeneity among all included studies. The pooled mean difference in weight loss was 8.9 kg (95% CI, 10.2–7.7; p < 0.01) and 2.8 kg/m² in BMI loss (95% CI, 3.4–2.2; p < 0.01). Long-term interventions produced superior weight loss (11.3 kg) compared to short-term (7.2 kg) and intermediate-term (8.0 kg) interventions. A significant global effect of lifestyle intervention on fat mass, waist circumference, blood pressure, total cholesterol, LDL-C, triglycerides and fasting insulin was found (p<0.01), without significant effect on HDL-C and fasting blood glucose. Conclusions Lifestyle interventions incorporating a PA component can improve weight and various cardiometabolic risk factors in class II

  9. Long-Term Post-Stroke Changes Include Myelin Loss, Specific Deficits in Sensory and Motor Behaviors and Complex Cognitive Impairment Detected Using Active Place Avoidance

    PubMed Central

    Li, Jie; Ooi, Evelyn; Bloom, Jonathan; Poon, Carrie; Lax, Daniel; Rosenbaum, Daniel M.; Barone, Frank C.

    2013-01-01

    Persistent neurobehavioral deficits and brain changes need validation for brain restoration. Two hours middle cerebral artery occlusion (tMCAO) or sham surgery was performed in male Sprague-Dawley rats. Neurobehavioral and cognitive deficits were measured over 10 weeks included: (1) sensory, motor, beam balance, reflex/abnormal responses, hindlimb placement, forepaw foot fault and cylinder placement tests, and (2) complex active place avoidance learning (APA) and simple passive avoidance retention (PA). Electroretinogram (ERG), hemispheric loss (infarction), hippocampus CA1 neuronal loss and myelin (Luxol Fast Blue) staining in several fiber tracts were also measured. In comparison to Sham surgery, tMCAO surgery produced significant deficits in all behavioral tests except reflex/abnormal responses. Acute, short lived deficits following tMCAO were observed for forelimb foot fault and forelimb cylinder placement. Persistent, sustained deficits for the whole 10 weeks were exhibited for motor (p<0.001), sensory (p<0.001), beam balance performance (p<0.01) and hindlimb placement behavior (p<0.01). tMCAO produced much greater and prolonged cognitive deficits in APA learning (maximum on last trial of 604±83% change, p<0.05) but only a small, comparative effect on PA retention. Hemispheric loss/atrophy was measured 10 weeks after tMCAO and cross-validated by two methods (e.g., almost identical % ischemic hemispheric loss of 33.4±3.5% for H&E and of 34.2±3.5% for TTC staining). No visual dysfunction by ERG and no hippocampus neuronal loss were detected after tMCAO. Fiber tract damage measured by Luxol Fast Blue myelin staining intensity was significant (p<0.01) in the external capsule and striatum but not in corpus callosum and anterior commissure. In summary, persistent neurobehavioral deficits were validated as important endpoints for stroke restorative research in the future. Fiber myelin loss appears to contribute to these long term behavioral dysfunctions and can be

  10. Long-term post-stroke changes include myelin loss, specific deficits in sensory and motor behaviors and complex cognitive impairment detected using active place avoidance.

    PubMed

    Zhou, Jin; Zhuang, Jian; Li, Jie; Ooi, Evelyn; Bloom, Jonathan; Poon, Carrie; Lax, Daniel; Rosenbaum, Daniel M; Barone, Frank C

    2013-01-01

    Persistent neurobehavioral deficits and brain changes need validation for brain restoration. Two hours middle cerebral artery occlusion (tMCAO) or sham surgery was performed in male Sprague-Dawley rats. Neurobehavioral and cognitive deficits were measured over 10 weeks included: (1) sensory, motor, beam balance, reflex/abnormal responses, hindlimb placement, forepaw foot fault and cylinder placement tests, and (2) complex active place avoidance learning (APA) and simple passive avoidance retention (PA). Electroretinogram (ERG), hemispheric loss (infarction), hippocampus CA1 neuronal loss and myelin (Luxol Fast Blue) staining in several fiber tracts were also measured. In comparison to Sham surgery, tMCAO surgery produced significant deficits in all behavioral tests except reflex/abnormal responses. Acute, short lived deficits following tMCAO were observed for forelimb foot fault and forelimb cylinder placement. Persistent, sustained deficits for the whole 10 weeks were exhibited for motor (p<0.001), sensory (p<0.001), beam balance performance (p<0.01) and hindlimb placement behavior (p<0.01). tMCAO produced much greater and prolonged cognitive deficits in APA learning (maximum on last trial of 604±83% change, p<0.05) but only a small, comparative effect on PA retention. Hemispheric loss/atrophy was measured 10 weeks after tMCAO and cross-validated by two methods (e.g., almost identical % ischemic hemispheric loss of 33.4±3.5% for H&E and of 34.2±3.5% for TTC staining). No visual dysfunction by ERG and no hippocampus neuronal loss were detected after tMCAO. Fiber tract damage measured by Luxol Fast Blue myelin staining intensity was significant (p<0.01) in the external capsule and striatum but not in corpus callosum and anterior commissure. In summary, persistent neurobehavioral deficits were validated as important endpoints for stroke restorative research in the future. Fiber myelin loss appears to contribute to these long term behavioral dysfunctions and can be

  11. The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri.

    PubMed

    Idelevich, Evgeny A; Schaumburg, Frieder; Knaack, Dennis; Scherzinger, Anna S; Mutter, Wolfgang; Peters, Georg; Peschel, Andreas; Becker, Karsten

    2016-04-01

    HY-133 is a recombinant bacteriophage endolysin with bactericidal activity againstStaphylococcus aureus Here, HY-133 showedin vitroactivity against major African methicillin-susceptible and methicillin-resistantS. aureuslineages and ceftaroline/ceftobiprole- and borderline oxacillin-resistant isolates. HY-133 was also active againstStaphylococcus schweitzeri, a recently described species of theS. aureuscomplex. The activity of HY-133 on the tested isolates (MIC50, 0.25 μg/ml; MIC90, 0.5 μg/ml; range, 0.125 to 0.5 μg/ml) was independent of the species and strain background or antibiotic resistance.

  12. Sierra Army Depot, Phase 1, remedial investigation/feasibility study, Lassen County, California. Appendices G-G. Final report

    SciTech Connect

    Not Available

    1991-10-01

    This report contains appendices G through Q2. Appendix G includes sieve analysis data, results from Atterberg Limits tests, soil classification and information concerning the hydraulic conductivity and permeability of the soils. Appendix H includes results of a geophysical survey. Appendix I lists information obtained from ground water sampling. Hydrographs are shown. Appendix I shows elevations and coordinates of monitoring wells and soil borings. Appendix K discusses a basin wide flow model at Honey Lake Valley. Appendix L shows results from pump tests which were conducted to obtain aquifer transmissivity, vertical conductivity and storage coefficients. Appendix M lists concentrations of chemical compounds in ground water and soils. Appendix N contains quality control results. Appendix O discusses the transport of contaminants through saturated soils and unsaturated soils. Appendix P contains data tables which list coordinates and elevations of boreholes and monitoring wells, field drilling sites and methods, well construction data, and concentrations of chemical in ground water and soils. Appendix Q1 discusses inhalation of and exposure to volatile organic chemicals while showering. Appendix Q2 lists the concentrations of metals and other chemical contaminants in soils and drinking water. Toxicity and health effects are discussed.

  13. Foothills Parkway Section 8B Final Environmental Report, Volume 4, Appendices E-I

    SciTech Connect

    Blasing, T.J.; Cada, G.F.; Carer, M.; Chin, S.M.; Dickerman, J.A.; Etnier, D.A.; Gibson, R.; Harvey, M.; Hatcher, B.; Lietzske, D.; Mann, L.K.; Mulholland, P.J.; Petrich, C.H.; Pounds, L.; Ranney, J.; Reed, R.M.; Ryan, P.F.; Schweitzer, M.; Smith, D.; Thomason, P.; Wade, M.C.

    1999-07-01

    In 1994, Oak Ridge National Laboratory (ORNL) was tasked by the National Park Service (NPS) to prepare an Environmental Report (ER) for Section 8B of the Foothills Parkway in the Great Smoky Mountains National Park (GSMNP). Section 8B represents 27.7 km (14.2 miles) of a total of 115 km (72 miles) of the planned Foothills Parkway and would connect the Cosby community on the east to the incorporated town of Pittman Center to the west. The major deliverables for the project are listed. From August 1995 through October 1996, NPS, GSMNP, and ORNL staff interacted with Federal Highway Administration staff to develop a conceptual design plan for Section 8B with the intent of protecting critical, resources identified during the ER process to the extent possible. In addition, ORNL arranged for bioengineering experts to discuss techniques that might be employed on Section 8B with NPS, GSMNP, and ORNL staff during September 1996. For the purposes of this ER, there are two basic alternatives under consideration: (1) a build alternative and (2) a no-build alternative. Within the build alternative are a number of options including constructing Section 8B with no interchanges, constructing Section 8B with an interchange at SR 416 or U.S. 321, constructing Section 8B with a spur road on Webb Mountain, and considering operation of Section 8B both before and after the operation of Section 8C. The no-build alternative is considered the no-action alternative and is not to construct Section 8B. This volume of the ER consists of Appendices E through I (all ecological survey reports), which are summarized individually in the sections that follow. The following conclusions result from the completion of these surveys and the ER impact analysis: (1) Forest clearing should be limited as much as possible; (2) Disturbed areas should be replanted with native trees; (3) Drainages should be bridged rather than leveled with cut and fill; (4) For areas of steep slopes and potential erosion

  14. Dystonia redefined as central non-paretic loss of control of muscle action: a concept including inability to activate muscles required for a specific movement, or 'negative dystonia'.

    PubMed

    Mezaki, Takahiro

    2007-01-01

    Dystonia is defined as a syndrome of sustained muscle contractions, frequently causing twisting and repetitive movements, or abnormal postures. Although this definition comprises an essential feature of dystonia, the clinical observation indicates that there is an additional aspect of dystonia; failure to adequately activate muscles required for specific movement, exemplified by the lack of contractions of the levator palpebrae superioris muscles in apraxia of lid opening, as well as by inability to activate appropriate muscles in cervical dystonia or in the paretic form of writer's cramp, and possibly by dropped head syndrome or camptocormia seen in parkinsonian patients without apparent truncal dystonia or rigidity. Taking this "negative dystonia" into consideration, the author proposes a revised definition of dystonia as a symptom characterized by the central non-paretic loss of voluntary control of muscle activities, which may result in either excessive or deficient contractions of muscles, frequently causing twisting and repetitive movements, limitation of movements, or abnormal postures.

  15. Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4.

    PubMed

    Slack, R J; Hall, D A

    2012-07-01

    BACKGROUND AND PURPOSE The operational model provides a key conceptual framework for the analysis of pharmacological data. However, this model does not include constitutive receptor activity, a frequent phenomenon in modern pharmacology, particularly in recombinant systems. Here, we developed extensions of the operational model which include constitutive activity and applied them to effects of agonists at the chemokine receptor CCR4. EXPERIMENTAL APPROACH The effects of agonists of CCR4 on [(35) S]GTPγS binding to recombinant cell membranes and on the filamentous (F-) actin content of human CD4(+) CCR4(+) T cells were determined. The basal [(35) S]GTPγS binding was changed by varying the GDP concentration whilst the basal F-actin contents of the higher expressing T cell populations were elevated, suggesting constitutive activity of CCR4. Both sets of data were analysed using the mathematical models. RESULTS The affinity of CCL17 (also known as TARC) derived from analysis of the T cell data (pK(a) = 9.61 ± 0.17) was consistent with radioligand binding experiments (9.50 ± 0.11) while that from the [(35) S]GTPγS binding experiments was lower (8.27 ± 0.09). Its intrinsic efficacy differed between the two systems (110 in T cells vs. 11). CONCLUSIONS AND IMPLICATIONS The presence of constitutive receptor activity allows the absolute intrinsic efficacy of agonists to be determined without a contribution from the signal transduction system. Intrinsic efficacy estimated in this way is consistent with Furchgott's definition of this property. CCL17 may have a higher intrinsic efficacy at CCR4 in human T cells than that expressed recombinantly in CHO cells.

  16. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.

    PubMed

    Pendergrast, P Shannon; Wang, Chen; Hernandez, Nouria; Huang, Sui

    2002-03-01

    FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically stimulate Tat activity and that this effect is dependent on the same domain of FBI-1 that mediates Tat-FBI-1 association in vivo. FBI-1 also partially colocalizes with Tat and Tat's cellular cofactor, P-TEFb (Cdk9 and cyclin T1), at the splicing-factor-rich nuclear speckle domain. Further, a less-soluble population of FBI-1 distributes in a novel peripheral-speckle pattern of localization as well as in other nuclear regions. This distribution pattern is dependent on the FBI-1 DNA binding domain, on the presence of cellular DNA, and on active transcription. Taken together, these results suggest that FBI-1 is a cellular factor that preferentially associates with active chromatin and that can specifically stimulate Tat-activated HIV-1 transcription.

  17. Speech Improvement for the Trainable Retarded: A Manual for the Classroom Teacher. Revised Edition. (Includes Speech Improvement Activity Book). NCEMMH Reprint Series.

    ERIC Educational Resources Information Center

    Lynch, Elizabeth; Ross, Jeanne

    Presented are 39 lessons and student worksheets designed to help the classroom teacher improve the speech skills of trainable retarded elementary school children. It is explained that the lessons and corresponding activity sheets focus on auditory discrimination, speech sounds and sentence patterns. Lessons are sequenced and usually contain a…

  18. Analysis of potential combustion source impacts on acid deposition using an independently derived inventory. Volume II, appendices

    SciTech Connect

    Not Available

    1983-12-01

    This document contains 2 appendices. The first documents the methodologies used to calculate production, unit energy consumption, fuel type and emission estimates for 16 industries and 35 types of facilities utilizing direct-fired industrial combustion processes, located in 26 states (and the District of Columbia) east of the Mississippi River. As discussed in the text of this report, a U.S. total of 16 industries and 45 types of facilities utilizing direct-fired combustion processes were identified by an elimination type method that was developed based on evaluation of fuel use in industrial SIC codes 20-39 to identify pollutant sources contributing to acid rain. The final population included only plants that have direct-fired fuel consumption greater than or equal to 100 x 10/sup 9/ Btu/yr of equivalent energy consumption. The goal for this analysis was to provide at least a 1980 base year for the data. This was achieved for all of the industries and in fact, 1981 data were used for a number of the industries evaluated. The second contains an analysis of all consumption of major fossil fuels to: (1) identify all fuel usage categories, and (2) identify the kinds of combustion equipment used within each category. This analysis provides a frame of reference for the balance of the study and permits using an energy accounting methodology to quantify the degree to which the inventoried sources in individual consuming sectors are complete and representative of the total population for the sector.

  19. Applying the model of Goal-Directed Behavior, including descriptive norms, to physical activity intentions: A contribution to improving the Theory of Planned Behavior

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The theory of planned behavior (TPB) has received its fair share of criticism lately, including calls for it to retire. We contributed to improving the theory by testing extensions such as the model of goal-directed behavior (MGDB, which adds desire and anticipated positive and negative emotions) ap...

  20. Sugar beet activities of the USDA-ARS East Lansing conducted in cooperation with Saginaw Valley Bean and Beet Farm during 2011 (including Project 905)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evaluation and rating plots were planted at the Saginaw Valley Research & Extension Center in Frankenmuth, MI in 2011 that focused on Cercospora leaf spot performance, conducted in conjunction with Beet Sugar Development Foundation and including USDA-ARS cooperators. 263 breeding lines were tested i...

  1. Mefloquine-oxazolidine derivatives, derived from mefloquine and arenecarbaldehydes: In vitro activity including against the multidrug-resistant tuberculosis strain T113.

    PubMed

    Gonçalves, Raoni S B; Kaiser, Carlos R; Lourenço, Maria C S; Bezerra, Flavio A F M; de Souza, Marcus V N; Wardell, James L; Wardell, Solange M S V; Henriques, Maria das Graças M de O; Costa, Thadeu

    2012-01-01

    Ten new mefloquine-oxazolidine derivatives, 4-[(1S,8aR)-3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline (1: aryl=substituted phenyl) and 4-[(1S,8aR)-3-(heteroaryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline [2: heteroaryl=5-nitrothien-2-yl (2a); 5-nitrofuran-2-yl (2b) and 4H-imidazol-2-yl) (2c)], have been synthesized and evaluated against Mycobacterium tuberculosis. Compounds 1f (aryl=3-ethoxyphenyl), 1g (Ar=3,4,5-(MeO)(3)-C(6)H(2)) and 2c were slightly more active than mefloquine (MIC=33μM) with MICs=24.5, 22.5 and 27.4, respectively, whereas compounds 1e (aryl=3,4-(MeO)(2)-C(6)H(3)) and 2a (MICs=11.9 and 12.1μM, respectively) were ca. 2.7 times more active than mefloquine, with a better tuberculostatic activity than the first line tuberculostatic agent ethambutol (MIC=15.9). The compounds were also assayed against the MDR strain T113 and the same MICs were observed. Thus the new derivatives have advantages over such anti-TB drugs as isoniazid, rifampicin, ethambutol and ofloxacin, for which this strain is resistant. The most active compounds were not cytotoxic to Murine Macrophages Cells in a concentration near their MIC values.

  2. Changes in free amino acid content and activities of amination and transamination enzymes in yeasts grown on different inorganic nitrogen sources, including hydroxylamine.

    PubMed

    Norkrans, B; Tunblad-Johansson, I

    1981-01-01

    This study concerns inter- and intraspecific differences between yeasts at assimilation of different nitrogen sources. Alterations in the content of free amino acids in cells and media as well as in the related enzyme activities during growth were studied. The hydroxylamine (HA)-tolerant Endomycopsis lipolytica was examined and compared with the nitrate-reducing Cryptococcus albidus, and Saccharomyces cerevisiae, requiring fully reduced nitrogen for growth. Special attention was paid to alanine, aspartic acid, and glutamic acid, the amino acids closely related to the Krebs cycle keto acids. The amino acids were analyzed as their n-propyl N-acetyl esters by gas-liquid chromatography (GLC). The composition of the amino acid pool was similar for the three yeasts. Glutamic acid was predominant; in early log-phase cells of E. lipolytica contents of 200-234 micromol . g(-1) dry weight were found. A positive correlation between the specific growth rate and the size of the amino acid pool was observed. The assimilation of ammonia was mediated by glutamate dehydrogenase (GDH). The NADP-GDH was the dominating enzyme in all three yeasts showing the highest specific activity in Cr. albidus grown on nitrate (6980 nmol . (min(-1)).(mg protein(-1)). Glutamine synthetase (GS) displayed a high specific activity in S. cerevisiae, which also had a high amount of glutamine. The assimilation of HA did not differ greatly from the assimilation of ammonium in E. lipolytica. The existing differences could rather be explained as provoked by the concentration of available nitrogen.

  3. Antibacterial Honey (Medihoney™): in-vitro Activity Against Clinical Isolates of MRSA, VRE, and Other Multiresistant Gram-negative Organisms Including Pseudomonas aeruginosa.

    PubMed

    George, Narelle May; Cutting, Keith F

    2007-09-01

    The clinical use of honey has received increasing interest in recent years, particularly its use as a topical antibacterial dressing. Results thus far are extremely encouraging, and demonstrate that honey is effective against a broad range of microorganisms, including multiresistant strains. This in-vitro study complements the work of others and focuses on the impact that a standardized honey can have on multiresistant bacteria that are regularly found in wounds and are responsible for increased morbidity.

  4. Activities of the Oil Implementation Task Force; Contracts for field projects and supporting research on enhanced oil recovery, July--September 1990

    SciTech Connect

    Tiedemann, H.A. )

    1991-05-01

    The report contains a general introduction and background to DOE's revised National Energy Strategy Advanced Oil Recovery Program and activities of the Oil Implementation Task Force; a detailed synopsis of the symposium, including technical presentations, comments and suggestions; a section of technical information on deltaic reservoirs; and appendices containing a comprehensive listing of references keyed to general deltaic and geological aspects of reservoirs and those relevant to six selected deltaic plays. Enhanced recovery processes include chemical floodings, gas displacement, thermal recovery, geoscience, and microbial recovery.

  5. Isolation of estrogen-degrading bacteria from an activated sludge bioreactor treating swine waste, including a strain that converts estrone to β-estradiol.

    PubMed

    Isabelle, Martine; Villemur, Richard; Juteau, Pierre; Lépine, François

    2011-07-01

    An estrogen-degrading bacterial consortium from a swine wastewater biotreatment was enriched in the presence of low concentrations (1 mg/L) of estrone (E1), 17β-estradiol (βE2), and equol (EQO) as sole carbon sources. The consortium removed 99% ± 1% of these three estrogens in 48 h. Estrogen removal occurred even in the presence of an ammonia monooxygenase inhibitor, suggesting that nitrifiers are not involved. Five strains showing estrogen-metabolizing activity were isolated from the consortium on mineral agar medium with estrogens as sole carbon source. They are related to four genera ( Methylobacterium (strain MI6.1R), Ochrobactrum (strains MI6.1B and MI9.3), Pseudomonas (strain MI14.1), and Mycobacterium (strain MI21.2)) distributed among three classes (Alphaproteobacteria, Gammaproteobacteria, and Actinobacteria). Depending on the culture medium, strains MI6.1B, MI9.3, MI14.1, and MI21.2 partially transform βE2 into E1, whereas Methylobacterium sp. strain MI6.1R reduces E1 into βE2 under aerobic conditions, in contrast with the usually observed conversion of βE2 into E1. Since βE2 is a more potent endocrine disruptor than E1, it means that the presence of Methylobacterium sp. strain MI6.1R (or other bacteria with the same E1-reducing activity) in a treatment could transiently increase the estrogenicity of the effluent. MI6.1R can also reduce the ketone group of 16-ketoestradiol, a hydroxylated analog of E1. All βE2 and E1 transformation activities were constitutive, and many of them are favoured in a rich medium than a medium containing no other carbon source. None of the isolated strains could degrade EQO.

  6. The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3 ▿ †

    PubMed Central

    Rahman, Shaila; Sowa, Mathew E.; Ottinger, Matthias; Smith, Jennifer A.; Shi, Yang; Harper, J. Wade; Howley, Peter M.

    2011-01-01

    Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and virus-host pathogenesis. To gain mechanistic insight into the various biological functions of Brd4, we performed a proteomic analysis to identify and characterize Brd4-associated cellular proteins. We found that the extraterminal (ET) domain, whose function has to date not been determined, interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5. These ET-domain interactions were also conserved for Brd2 and Brd3, the other human BET proteins tested. We demonstrated that GLTSCR1, NSD3, and JMJD6 impart a pTEFb-independent transcriptional activation function on Brd4. NSD3 as well as JMJD6 is recruited to regulated genes in a Brd4-dependent manner. Moreover, we found that depletion of Brd4 or NSD3 reduces H3K36 methylation, demonstrating that the Brd4/NSD3 complex regulates this specific histone modification. Our results indicate that the Brd4 ET domain through the recruitment of the specific effectors regulates transcriptional activity. In particular, we show that one of these effectors, NSD3, regulates transcription by modifying the chromatin microenvironment at Brd4 target genes. Our study thus identifies the ET domain as a second important transcriptional regulatory domain for Brd4 in addition to the carboxyl-terminal domain (CTD) that interacts with pTEFb. PMID:21555454

  7. Routine Radiological Environmental Monitoring Plan, Volume 2 Appendices

    SciTech Connect

    Bechtel Nevada

    1998-12-31

    Supporting material for the plan includes: QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR NTS AIR; QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR WATER ON AND OFF THE NEVADA TEST SITE; QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR NTS BIOTA; QUALITY ASSURANCE, ANALYSIS, AND SAMPLING PLAN FOR DIRECT RADIATION MONITORING; DATA QUALITY OBJECTIVES PROCESS; VADOSE ZONE MONITORING PLAN CHECKLIST.

  8. Effect of pH, water activity and gel micro-structure, including oxygen profiles and rheological characterization, on the growth kinetics of Salmonella Typhimurium.

    PubMed

    Theys, T E; Geeraerd, A H; Verhulst, A; Poot, K; Van Bree, I; Devlieghere, F; Moldenaers, P; Wilson, D; Brocklehurst, T; Van Impe, J F

    2008-11-30

    In this study, the growth of Salmonella Typhimurium in Tryptic Soy Broth was examined at different pH (4.50-5.50), water activity a(w) (0.970-0.992) and gelatin concentration (0%, 1% and 5% ) at 20 degrees C. Experiments in TSB with 0% gelatin were carried out in shaken erlenmeyers, in the weak 1% gelatin media in petri plates and in the firm 5% gelatin media in gel cassettes. A quantification of gel strength was performed by rheological measurements and the influence of oxygen supply on the growth of S. Typhimurium was investigated. pH, as well as a(w) as well as gelatin concentration had an influence on the growth rate. Both in broth and in gelatinized media, lowering pH or water activity caused a decrease of growth rate. In media with 1% gelatin a reduction of growth rate and maximal cell density was observed compared to broth at all conditions. However, the effects of decreasing pH and a(w) were less pronounced. A further increase in gelatin concentration to 5% gelatin caused a small or no additional drop of growth rate. The final oxygen concentration dropped from 5.5 ppm in stirred broth to anoxic values in petri plates, also when 0% and 5% gelatin media were tested in this recipient. Probably, not stirring the medium, which leads to anoxic conditions, has a more pronounced effect on the growth rate of S. Typhimurium then medium solidness. Finally, growth data were fitted with the primary model of Baranyi and Roberts [Baranyi, J. and Roberts, T. A., 1994. A dynamic approach to predicting bacterial growth in food. International Journal of Food Microbiology 23, 277-294]. An additional factor was introduced into the secondary model of Ross et al. [Ross, T. and Ratkowsky, D. A. and Mellefont, L. A. and McMeekin, T. A., 2003. Modelling the effects of temperature, water activity, pH and lactic acid concentration on the growth rate of Escherichia coli. International Journal of Food Microbiology 82, 33-43.] to incorporate the effect of gelatin concentration, next to

  9. The role of mast cells in histologically "normal" appendices following emergency appendectomy in pediatric patients.

    PubMed

    Yang, Zhongbo; Esebua, Magda; Layfield, Lester

    2016-10-01

    Fifteen percent to 25% of appendices resected for a preoperative diagnosis of acute appendicitis have no neutrophilic infiltration, thus histologically "normal." The discrepancy between clinical presentation and the lack of definite morphologic changes is confounding. It has been indicated that mast cells may play a role in the pathogenesis of the appendicitis-like pain in patients with histologically negative appendices (HNAs). To investigate whether mast cell density (MCD) is increased in pediatric HNAs, we retrieved 50 appendectomy cases (30 HNA and 20 control, ages 2 days-18 years) in our institute in the last 10 years. All cases were stained with mast cell tryptase by immunohistochemistry, and MCD (count/high-power field) was measured in mucosa, submucosa, muscularis, and serosa. Mast cells had the greatest density in the mucosa, followed by the submucosa, in all appendices. MCDs in all 4 layers were significantly higher in HNAs than in the normal controls (mucosa: 46±9 vs 26±11, P<.01; submucosa: 18±5 vs 11±5, P<.01; muscularis: 6±3 vs 4±2, P<.01; serosa: 6±2 vs 4±2, P<.01). This result suggests that mast cells play an important role in pathogenesis of HNA cases. In clinical practice, pathologists may order immunohistochemical stains for mast cells in cases with no classic histologic findings of acute appendicitis following emergency appendectomy. If increased MCD is noted, the case may be reported as "appendicitis with increased mast cells." This assures surgeons that the appendectomy is the correct treatment and it is not necessary to look for other causes of acute abdomen. This is especially important in children.

  10. The Coordinated Noninvasive Studies (CNS) Project. Phase 1. Appendices

    DTIC Science & Technology

    1991-12-01

    our PET library of 29 studie using auditory stimulation in 0 normal young adults to document patterns of global brain asymmetries . The first two...Advisor) "Regional cerebral blood flow activation asymmetries in human brains during rest and auditory stimulation" (1989) Ph.D. Dissertations: Carol...Soc Amer 85: S38. "Global brain asymmetries in regional cerebral blood flow (rCBF) during resting conditions with positron emission tomography (PET

  11. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells

    SciTech Connect

    Gao Jiayu; Morgan, Winston A.; Sanchez-Medina, Alberto; Corcoran, Olivia

    2011-08-01

    Despite a lack of scientific authentication, Scutellaria baicalensis is clinically used in Chinese medicine as a traditional adjuvant to chemotherapy of lung cancer. In this study, cytotoxicity assays demonstrated that crude ethanolic extracts of S. baicalensis were selectively toxic to human lung cancer cell lines A549, SK-LU-1 and SK-MES-1 compared with normal human lung fibroblasts. The active compounds baicalin, baicalein and wogonin did not exhibit such selectivity. Following exposure to the crude extracts, cellular protein expression in the cancer cell lines was assessed using 2D gel electrophoresis coupled with MALDI-TOF-MS/Protein Fingerprinting. The altered protein expression indicated that cell growth arrest and apoptosis were potential mechanisms of cytotoxicity. These observations were supported by PI staining cell cycle analysis using flow cytometry and Annexin-V apoptotic analysis by fluorescence microscopy of cancer cells treated with the crude extract and pure active compounds. Moreover, specific immunoblotting identification showed the decreased expression of cyclin A results in the S phase arrest of A549 whereas the G{sub 0}/G{sub 1} phase arrest in SK-MES-1 cells results from the decreased expression of cyclin D1. Following treatment, increased expression in the cancer cells of key proteins related to the enhancement of apoptosis was observed for p53 and Bax. These results provide further insight into the molecular mechanisms underlying the clinical use of this herb as an adjuvant to lung cancer therapy. - Research Highlights: > Scutellaria baicalensis is a clinical adjuvant to lung cancer chemotherapy in China. > Scutellaria ethanol extracts selectively toxic to A549, SK-LU-1 and SK-MES-1. > Baicalin, baicalein and wogonin were toxic to all lung cancer cell lines. > Proteomics identified increased p53 and BAX in response to Scutellaria extracts.

  12. Heterogeneity in Pseudomonas aeruginosa Biofilms Includes Expression of Ribosome Hibernation Factors in the Antibiotic-Tolerant Subpopulation and Hypoxia-Induced Stress Response in the Metabolically Active Population

    PubMed Central

    Williamson, Kerry S.; Richards, Lee A.; Perez-Osorio, Ailyn C.; Pitts, Betsey; McInnerney, Kathleen; Stewart, Philip S.

    2012-01-01

    Bacteria growing in biofilms are physiologically heterogeneous, due in part to their adaptation to local environmental conditions. Here, we characterized the local transcriptome responses of Pseudomonas aeruginosa growing in biofilms by using a microarray analysis of isolated biofilm subpopulations. The results demonstrated that cells at the top of the biofilms had high mRNA abundances for genes involved in general metabolic functions, while mRNA levels for these housekeeping genes were low in cells at the bottom of the biofilms. Selective green fluorescent protein (GFP) labeling showed that cells at the top of the biofilm were actively dividing. However, the dividing cells had high mRNA levels for genes regulated by the hypoxia-induced regulator Anr. Slow-growing cells deep in the biofilms had little expression of Anr-regulated genes and may have experienced long-term anoxia. Transcripts for ribosomal proteins were associated primarily with the metabolically active cell fraction, while ribosomal RNAs were abundant throughout the biofilms, indicating that ribosomes are stably maintained even in slowly growing cells. Consistent with these results was the identification of mRNAs for ribosome hibernation factors (the rmf and PA4463 genes) at the bottom of the biofilms. The dormant biofilm cells of a P. aeruginosa Δrmf strain had decreased membrane integrity, as shown by propidium iodide staining. Using selective GFP labeling and cell sorting, we show that the dividing cells are more susceptible to killing by tobramycin and ciprofloxacin. The results demonstrate that in thick P. aeruginosa biofilms, cells are physiologically distinct spatially, with cells deep in the biofilm in a viable but antibiotic-tolerant slow-growth state. PMID:22343293

  13. Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-β

    PubMed Central

    Salazar, Juan C.; Duhnam-Ems, Star; La Vake, Carson; Cruz, Adriana R.; Moore, Meagan W.; Caimano, Melissa J.; Velez-Climent, Leonor; Shupe, Jonathan; Krueger, Winfried; Radolf, Justin D.

    2009-01-01

    It is widely believed that innate immune responses to Borrelia burgdorferi (Bb) are primarily triggered by the spirochete's outer membrane lipoproteins signaling through cell surface TLR1/2. We recently challenged this notion by demonstrating that phagocytosis of live Bb by peripheral blood mononuclear cells (PBMCs) elicited greater production of proinflammatory cytokines than did equivalent bacterial lysates. Using whole genome microarrays, we show herein that, compared to lysates, live spirochetes elicited a more intense and much broader transcriptional response involving genes associated with diverse cellular processes; among these were IFN-β and a number of interferon-stimulated genes (ISGs), which are not known to result from TLR2 signaling. Using isolated monocytes, we demonstrated that cell activation signals elicited by live Bb result from cell surface interactions and uptake and degradation of organisms within phagosomes. As with PBCMs, live Bb induced markedly greater transcription and secretion of TNF-α, IL-6, IL-10 and IL-1β in monocytes than did lysates. Secreted IL-18, which, like IL-1β, also requires cleavage by activated caspase-1, was generated only in response to live Bb. Pro-inflammatory cytokine production by TLR2-deficient murine macrophages was only moderately diminished in response to live Bb but was drastically impaired against lysates; TLR2 deficiency had no significant effect on uptake and degradation of spirochetes. As with PBMCs, live Bb was a much more potent inducer of IFN-β and ISGs in isolated monocytes than were lysates or a synthetic TLR2 agonist. Collectively, our results indicate that the enhanced innate immune responses of monocytes following phagocytosis of live Bb have both TLR2-dependent and -independent components and that the latter induce transcription of type I IFNs and ISGs. PMID:19461888

  14. In Planta Expression Screens of Phytophthora infestans RXLR Effectors Reveal Diverse Phenotypes, Including Activation of the Solanum bulbocastanum Disease Resistance Protein Rpi-blb2[W

    PubMed Central

    Oh, Sang-Keun; Young, Carolyn; Lee, Minkyoung; Oliva, Ricardo; Bozkurt, Tolga O.; Cano, Liliana M.; Win, Joe; Bos, Jorunn I.B.; Liu, Hsin-Yin; van Damme, Mireille; Morgan, William; Choi, Doil; Van der Vossen, Edwin A.G.; Vleeshouwers, Vivianne G.A.A.; Kamoun, Sophien

    2009-01-01

    The Irish potato famine pathogen Phytophthora infestans is predicted to secrete hundreds of effector proteins. To address the challenge of assigning biological functions to computationally predicted effector genes, we combined allele mining with high-throughput in planta expression. We developed a library of 62 infection-ready P. infestans RXLR effector clones, obtained using primer pairs corresponding to 32 genes and assigned activities to several of these genes. This approach revealed that 16 of the 62 examined effectors cause phenotypes when expressed inside plant cells. Besides the well-studied AVR3a effector, two additional effectors, PexRD8 and PexRD3645-1, suppressed the hypersensitive cell death triggered by the elicitin INF1, another secreted protein of P. infestans. One effector, PexRD2, promoted cell death in Nicotiana benthamiana and other solanaceous plants. Finally, two families of effectors induced hypersensitive cell death specifically in the presence of the Solanum bulbocastanum late blight resistance genes Rpi-blb1 and Rpi-blb2, thereby exhibiting the activities expected for Avrblb1 and Avrblb2. The AVRblb2 family was then studied in more detail and found to be highly variable and under diversifying selection in P. infestans. Structure-function experiments indicated that a 34–amino acid region in the C-terminal half of AVRblb2 is sufficient for triggering Rpi-blb2 hypersensitivity and that a single positively selected AVRblb2 residue is critical for recognition by Rpi-blb2. PMID:19794118

  15. Percutaneous Radiofrequency Ablation of a Small Renal Mass Complicated by Appendiceal Perforation

    SciTech Connect

    Boone, Judith; Bex, Axel; Prevoo, Warner

    2012-06-15

    Percutaneous radiofrequency ablation (RFA) has gained wide acceptance as nephron-sparing therapy for small renal masses in select patients. Generally, it is a safe procedure with minor morbidity and acceptable short-term oncologic outcome. However, as a result of the close proximity of vital structures, such as the bowel, ureter, and large vessels, to the ablative field, complications regarding these structures may occur. This is the first article describing appendiceal perforation as a complication of computed tomography-guided RFA despite hydrodissection. When performing this innovative and promising procedure one should be aware of the possibility of particular minor and even major complications.

  16. Technology, Safety and Costs of Decommissioning a Reference Low-Level Waste Burial Ground. Appendices

    SciTech Connect

    1980-06-01

    Safety and cost information are developed for the conceptual decommissioning of commercial low-level waste (LLW) burial grounds. Two generic burial grounds, one located on an arid western site and the other located on a humid eastern site, are used as reference facilities for the study. The two burial grounds are assumed to have the same site capacity for waste, the same radioactive waste inventory, and similar trench characteristics and operating procedures. The climate, geology. and hydrology of the two sites are chosen to be typical of real western and eastern sites. Volume 2 (Appendices) contains the detailed analyses and data needed to support the results given in Volume 1.

  17. Independent Assessment of Instrumentation for ISS On-Orbit NDE. Volume 2; Appendices

    NASA Technical Reports Server (NTRS)

    Madaras, Eric I.

    2013-01-01

    International Space Station (ISS) Structural and Mechanical Systems Manager, requested that the NASA Engineering and Safety Center (NESC) provide a quantitative assessment of commercially available nondestructive evaluation (NDE) instruments for potential application to the ISS. This work supports risk mitigation as outlined in the ISS Integrated Risk Management Application (IRMA) Watch Item #4669, which addresses the requirement for structural integrity after an ISS pressure wall leak in the event of a penetration due to micrometeoroid or debris (MMOD) impact. This document contains the appendices the final report.

  18. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading: Appendices

    NASA Technical Reports Server (NTRS)

    Gentz, Steven J.; Ordway, David O.; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.

    2015-01-01

    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (approx. 9 inches from the source) dominated by direct wave propagation, mid-field environment (approx. 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This document contains appendices to the Volume I report.

  19. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading. [Appendices

    NASA Technical Reports Server (NTRS)

    Gentz, Steven J.; Ordway, David O.; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.

    2015-01-01

    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (9 inches from the source) dominated by direct wave propagation, mid-field environment (approximately 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This document contains appendices to the Volume I report.

  20. Evaluation of Agency Non-Code Layered Pressure Vessels (LPVs) . Volume 2; Appendices

    NASA Technical Reports Server (NTRS)

    Prosser, William H.

    2014-01-01

    In coordination with the Office of Safety and Mission Assurance and the respective Center Pressure System Managers (PSMs), the NASA Engineering and Safety Center (NESC) was requested to formulate a consensus draft proposal for the development of additional testing and analysis methods to establish the technical validity, and any limitation thereof, for the continued safe operation of facility non-code layered pressure vessels. The PSMs from each NASA Center were asked to participate as part of the assessment team by providing, collecting, and reviewing data regarding current operations of these vessels. This document contains the appendices to the main report.

  1. Necrotizing Fasciitis Arising From an Enterocutaneous Fistula in a Case of an Appendiceal Mucocele.

    PubMed

    Kim, Keun Young; Park, Won Cheol

    2015-12-01

    An appendiceal mucocele (AM) is a rare tumorous condition of the appendix. Many patients with AM are admitted to the hospital with abdominal pain or discomfort, and many cases are found incidentally. Although the rate of complications in patients with AM is very low, if left untreated, a mucocele may rupture and produce a potentially fatal entity known as pseudomyxoma peritonei. In this paper, we report a case of an 80-year-old man with necrotizing fasciitis arising from an enterocutaneous fistula caused by AM.

  2. Necrotizing Fasciitis Arising From an Enterocutaneous Fistula in a Case of an Appendiceal Mucocele

    PubMed Central

    Kim, Keun Young

    2015-01-01

    An appendiceal mucocele (AM) is a rare tumorous condition of the appendix. Many patients with AM are admitted to the hospital with abdominal pain or discomfort, and many cases are found incidentally. Although the rate of complications in patients with AM is very low, if left untreated, a mucocele may rupture and produce a potentially fatal entity known as pseudomyxoma peritonei. In this paper, we report a case of an 80-year-old man with necrotizing fasciitis arising from an enterocutaneous fistula caused by AM. PMID:26817021

  3. Technical area status report for chemical/physical treatment. Volume 2, Appendices

    SciTech Connect

    Brown, C.H. Jr.; Schwinkendorf, W.E.

    1993-08-01

    These Appendices describe various technologies that may be applicable to the Mixed Waste Treatment Plant (MWTP) Chemical/Physical Treatment System (CPTS). These technologies were identified by the CPTS Technical Support Group (TSG) as potentially applicable to a variety of separation, volume reduction, and decontamination requirements. The purpose was to identify all available and developing technologies, and their characteristics, for subsequent evaluation for specific requirements identified for the CPTS. However, the technologies described herein are not necessarily all inclusive, nor are they necessarily all applicable.

  4. Report to Congress on Server and Data Center Energy Efficiency: Public Law 109-431: Appendices

    SciTech Connect

    Alliance to Save Energy; ICF Incorporated; ERG Incorporated; U.S. Environmental Protection Agency; Brown, Richard E; Brown, Richard; Masanet, Eric; Nordman, Bruce; Tschudi, Bill; Shehabi, Arman; Stanley, John; Koomey, Jonathan; Sartor, Dale; Chan, Peter; Loper, Joe; Capana, Steve; Hedman, Bruce; Duff, Rebecca; Haines, Evan; Sass, Danielle; Fanara, Andrew

    2007-08-02

    This report is the appendices to a companion report, prepared in response to the request from Congress stated in Public Law 109-431 (H.R. 5646),"An Act to Study and Promote the Use of Energy Efficient Computer Servers in the United States." This report assesses current trends in energy use and energy costs of data centers and servers in the U.S. (especially Federal government facilities) and outlines existing and emerging opportunities for improved energy efficiency. It also makes recommendations for pursuing these energy-efficiency opportunities broadly across the country through the use of information and incentive-based programs.

  5. All Source Analysis System (ASAS). Block 1. Abbreviated HARDMAN analysis. Appendices to Volume 1

    DTIC Science & Technology

    1992-04-01

    8217 APPENDICES A. TSE WCG Maintenance Data B. TSE DPS Maintenance Data C. CCS Maintenance Data D. TCAE Workstation Maintenance Data E. TCAC Maintenance Data...Division TCAE G(3) SUP - 3 Light Division TSE G(4) SUP - 4 Light Division TCAE H. Unit Maintenance Data Summary I. Heavy Division Maintenance Data J...V u Appendix D TCAE W/S Maintenance Data c a a -0 C 0 coca46 Ci a a a a c a a 0 a a 0 coca01009P 0 IRMO. : C!000110 1 N 010 4#41111114 1 Im *lq##4CC

  6. User's guide to HELIOS: A computer program for modeling the optical behavior of reflecting solar concentrators. Part 3: Appendices concerning HELIOS-code details

    NASA Astrophysics Data System (ADS)

    Vittitoe, C. N.; Biss, F.

    1981-09-01

    HELIOS is a flexible computer code for evaluating designs for central-receiver, parabolic-dish, and other reflecting solar-energy collector systems; for safety calculations on the threat to personnel and to the facility itself; for determination of how various input parameters alter the power collected; for design trade-offs; and for heliostat evaluations. Input variables include atmospheric transmission effects; reflector shape, surface, and suntracking errors; focusing and alignment strategies; receiver design; placement positions of the tower and mirrors; time-of-day and day-of-year for the calculation. Part III is a series of appendices giving code details for subroutine and function descriptions, how common blocks are used, sample jobstreams, and magnetic tape use within the code.

  7. Guidelines on the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal surface malignancy arising from colorectal or appendiceal neoplasms

    PubMed Central

    Dubé, P.; Sideris, L.; Law, C.; Mack, L.; Haase, E.; Giacomantonio, C.; Govindarajan, A.; Krzyzanowska, M.K.; Major, P.; McConnell, Y.; Temple, W.; Younan, R.; McCart, J.A.

    2015-01-01

    To meet the needs of patients, Canadian surgical and medical oncology leaders in the treatment of peritoneal surface malignancies (psms), together with patient representatives, formed the Canadian HIPEC Collaborative Group (chicg). The group is dedicated to standardizing and improving the treatment of psm in Canada so that access to treatment and, ultimately, the prognosis of Canadian patients with psm are improved. Patients with resectable psm arising from colorectal or appendiceal neoplasms should be reviewed by a multidisciplinary team including surgeons and medical oncologists with experience in treating patients with psm. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy should be offered to appropriately selected patients and performed at experienced centres. The aim of this publication is to present guidelines that we recommend be applied across the country for the treatment of psm. PMID:25908915

  8. Analytical evaluation of ILM sensors. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    Kirk, R. J.

    1975-01-01

    The applicability of various sensing concepts to independent landing monitor systems was analyzed. Microwave landing system MLS accuracy requirements are presented along with a description of MLS airborne equipment. Computer programs developed during the analysis are described and include: a mathematical computer model for use in the performance assessment of reconnaissance sensor systems; a theoretical formulation of electromagnetic scattering to generate data at high incidence angles; atmospheric attenuation of microwaves; and microwave radiometry, programs

  9. Space Station crew safety alternatives study. Volume 4: Appendices

    NASA Technical Reports Server (NTRS)

    Peercy, R. L., Jr.; Raasch, R. F.; Rockoff, L. A.

    1985-01-01

    The scope of this study considered the first 15 years of accumulated space station concepts for Initial Operational Capability (10C) during the early 1990's. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris.

  10. Studies and analyses of the management of scientific research and development, including implementation and application at NASA centers

    NASA Technical Reports Server (NTRS)

    Rubenstein, A. H.

    1975-01-01

    Summary results obtained through the Program of Research on the Management of Research and Development (POMRAD) were presented. The nature of the overall program and the specific projects undertaken were described. Statistical data is also given concerning the papers, publications, people, and major program areas associated with the program. The actual list of papers, names of doctoral and masters theses, and other details of the program are included as appendices.

  11. Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex.

    PubMed

    Sui, Dexin; Xu, Xinjing; Ye, Xuemei; Liu, Mengyu; Mianecki, Maxwell; Rattanasinchai, Chotirat; Buehl, Christopher; Deng, Xiexiong; Kuo, Min-Hao

    2015-01-01

    Many biomedically critical proteins are underrepresented in proteomics and biochemical studies because of the difficulty of their production in Escherichia coli. These proteins might possess posttranslational modifications vital to their functions, tend to misfold and be partitioned into bacterial inclusion bodies, or act only in a stoichiometric dimeric complex. Successful production of these proteins requires efficient interaction between these proteins and a specific "facilitator," such as a protein-modifying enzyme, a molecular chaperone, or a natural physical partner within the dimeric complex. Here we report the design and application of a protein interaction module-assisted function X (PIMAX) system that effectively overcomes these hurdles. By fusing two proteins of interest to a pair of well-studied protein-protein interaction modules, we were able to potentiate the association of these two proteins, resulting in successful production of an enzymatically active cyclin-dependent kinase complex and hyperphosphorylated tau protein, which is intimately linked to Alzheimer disease. Furthermore, using tau isoforms quantitatively phosphorylated by GSK-3β and CDK5 kinases via PIMAX, we demonstrated the hyperphosphorylation-stimulated tau oligomerization in vitro, paving the way for new Alzheimer disease drug discoveries. Vectors for PIMAX can be easily modified to meet the needs of different applications. This approach thus provides a convenient and modular suite with broad implications for proteomics and biomedical research.

  12. Implementation of a comprehensive program including psycho-social and treatment literacy activities to improve adherence to HIV care and treatment for a pediatric population in Kenya

    PubMed Central

    Van Winghem, Joelle; Telfer, Barbara; Reid, Tony; Ouko, Judith; Mutunga, Angela; Jama, Zaina; Vakil, Shobha

    2008-01-01

    Background To achieve good clinical outcomes with HAART, patient adherence to treatment and care is a key factor. Since the literature on how to care for pediatric HIV patients is limited, we describe here adherence interventions implemented in our comprehensive care program in a resource-limited setting in Kenya. Methods We based our program on factors reported to influence adherence to HIV care and treatment. We describe, in detail, our program with respect to how we adapted our clinical settings, implemented psycho-social support activities for children and their caregivers and developed treatment literacy for children and teenagers living with HIV/AIDS. Results This paper focused on the details of the program, with the treatment outcomes as secondary. However, our program appeared to have been effective; for 648 children under 15 years of age who were started on HAART, the Kaplan-Meier mortality survival estimate was 95.27% (95%CI 93.16–96.74) at 12 months after the time of initiation of HAART. Conclusion Our model of pediatric HIV/AIDS care, focused on a child-centered approach with inclusion of caregivers and extended family, addressed the main factors influencing treatment adherence. It appeared to produce good results and is replicable in resource-limited settings. PMID:19025581

  13. Building Astronomy Curriculum to Include the Sight Impaired: Week long summer camp activities for Middle School Students adherent to Washington State Curriculum Standards (EALR's)

    NASA Astrophysics Data System (ADS)

    Ramien, Natalie; Loebman, S. R.; Player, V.; Larson, A.; Torcolini, N. B.; Traverse, A.

    2011-01-01

    Currently astronomy learning is heavily geared towards visual aids; however, roughly 10 million people in North America are sight impaired. Every student should have access to meaningful astronomy curriculum; an understanding of astronomy is an expectation of national and state science learning requirements. Over the last ten years, Noreen Grice has developed Braille and large print astronomy text books aimed at sight impaired learners. We build upon Grice's written work and present here a five day lesson plan that integrates 2D reading with 3D activities. Through this curriculum, students develop an intuitive understanding of astronomical distance, size, composition and lifetimes. We present five distinct lesson modules that can be taught individually or in a sequential form: the planets, our sun, stars, stellar evolution and galaxies. We have tested these modules on sight impaired students and report the results here. Overall, we find the work presented here lends itself equally well to a week long science camp geared toward middle school sight impaired taught by astronomers or as supplemental material integrated into a regular classroom science curriculum. This work was made possible by a 2007 Simple Effective Education and Dissemination (SEED) Grant For Astronomy Researchers, Astronomical Society of the Pacific through funds provided by the Planck Mission, Jet Propulsion Laboratory, California Institute of Technology.

  14. Radionuclides in small mammals of the Saskatchewan prairie, including implications for the boreal forest and Arctic tundra

    SciTech Connect

    Thomas, P.A.

    1995-12-31

    The focus of the study reported was to collect and examine baseline data on radionuclides in small prairie mammal food chains and to assess the feasibility of using small mammals as radionuclide monitors in terrestrial ecosystems, in anticipation of possible future nuclear developments in northern Saskatchewan and the Northwest Territories. The study report begins with a literature review that summarizes existing data on radionuclides in small mammals, their food, the ambient environment in Canadian terrestrial ecosystems, principles of terrestrial radioecology, soil and vegetation studies, and food chain studies. It then describes a field study conducted to investigate small mammal food chains at three southwestern Saskatchewan prairie sites. Activities included collection and analysis of water, soil, grains, and foliage samples; trapping of small mammals such as mice and voles, and analysis of gastrointestinal tract samples; and determination of food chain transfer of selected radionuclides from soil to plants and to small mammals. Recommendations are made for future analyses and monitoring of small mammals. Appendices include information on radiochemical methods, soil/vegetation studies and small mammal studies conducted at northern Saskatchewan mine sites, and analyses of variance.

  15. Benthic food web structure in the Comau fjord, Chile (∼42°S): Preliminary assessment including a site with chemosynthetic activity

    NASA Astrophysics Data System (ADS)

    Zapata-Hernández, Germán; Sellanes, Javier; Mayr, Christoph; Muñoz, Práxedes

    2014-12-01

    Using C and N stable isotopes we analyzed different trophic aspects of the benthic fauna at two sites in the Comau fjord: one with presence of venting of chemically reducing fluids and extensive patches of bacterial mats (XH: X-Huinay), and one control site (PG: Punta Gruesa) with a typical fjord benthic habitat. Due to the widespread presence of such microbial patches in the fjord and their recognized trophic role in reducing environments, we hypothesize that these microbial communities could be contributing to the assimilated food of consumers and transferring carbon into high trophic levels in the food web. Food sources in the area included macroalgae with a wide range of δ13C values (-34.7 to -11.9‰), particulate organic matter (POM, δ13C = -20.1‰), terrestrial organic matter (TOM, δ13C = -32.3‰ to -27.9‰) and chemosynthetic filamentous bacteria (δ13C = ∼-33‰). At both sites, fauna depicted typical values indicating photosynthetic production as a main food source (>-20‰). However, at XH selected taxa reported lower δ13C values (e.g. -26.5‰ in Nacella deaurata), suggesting a partial use of chemosynthetic production. Furthermore, enhanced variability at this site in δ13C values of the polyplacophoran Chiton magnificus, the limpet Fissurella picta and the tanaid Zeuxoides sp. may also be responding to the use of a wider scope of primary food sources. Trophic position estimates suggest three trophic levels of consumers at both sites. However, low δ15N values in some grazer and suspension-feeder species suggest that these taxa could be using other sources still to be identified (e.g. bacterial films, microalgae and organic particles of small size-fractions). Furthermore, between-site comparisons of isotopic niche width measurements in some trophic guilds indicate that grazers from XH have more heterogenic trophic niches than at PG (measured as mean distance to centroid and standard deviation of nearest neighbor distance). This last could be

  16. Chemosynthetic ecosystems study. Final report. Volume 3. Appendices

    SciTech Connect

    MacDonald, I.R.; Sager, W.W.; Lee, C.; Schroeder, W.W.; Kennicutt, M.C.

    1995-06-01

    Volume III presents ancillary materials from the findings of a three year investigation of the geology, chemistry and biology of chemosynthetic ecosystems in the Gulf of Mexico. These dense assemblages of tube worms, mussels and/or clams are primarily dependent upon chemical conditions generated by natural oil and gas seeps. Hydrocarbon seeps produce a variety of distinctive geological features including carbonate rock, mud volcanoes and hydrate mounds, which tend to be localized to areas less than 1 km. The interaction of the sediment bacteria with the hydrocarbons in the seafloor yields a highly specialized chemical environment featuring high levels of hydrogen sulfide and degraded oils. The biological community is supported by chemoautotrophic bacteria that live symbiotically with tube worms, mussels and clams.

  17. Pump apparatus including deconsolidator

    DOEpatents

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  18. Comparing bottom-up and top-down approaches at the landscape scale, including agricultural activities and water systems, at the Roskilde Fjord, Denmark

    NASA Astrophysics Data System (ADS)

    Lequy, Emeline; Ibrom, Andreas; Ambus, Per; Massad, Raia-Silvia; Markager, Stiig; Asmala, Eero; Garnier, Josette; Gabrielle, Benoit; Loubet, Benjamin

    2015-04-01

    The greenhouse gas nitrous oxide (N2O) mainly originates in direct emissions from agricultural soils due to microbial reactions stimulated by the use of nitrogen fertilisers. Indirect N2O emissions from water systems due to nitrogen leaching and deposition from crop fields range between 26 and 37% of direct agricultural emissions, indicating their potential importance and uncertainty (Reay et al. 2012). The study presented here couples a top-down approach with eddy covariance (EC) and a bottom-up approach using different models and measurements. A QCL sensor at 96-m height on a tall tower measures the emissions of N2O from 1100 ha of crop fields and from the south part of the Roskilde fjord, in a 5-km radius area around the tall tower at Roskilde, Denmark. The bottom-up approach includes ecosystem modelling with CERES-EGC for the crops and PaSIM for the grasslands, and the N2O fluxes from the Roskilde fjord are derived from N2O sea water concentration measurements. EC measurements are now available from July to December 2014, and indicate a magnitude of the emissions from the crop fields around 0.2 mg N2O-N m-2 day-1 (range -9 to 5) which is consistent with the CERES-EGC simulations and calculations using IPCC emission factors. N2O fluxes from the Roskilde fjord in May and July indicated quite constant N2O concentrations around 0.1 µg N L-1 despite variations of nitrate and ammonium in the fjord. The calculated fluxes from these concentrations and the tall tower measurements consistently ranged between -7 and 6 mg N2O-N m-2 day-1. The study site also contains a waste water treatment plant, whose direct emissions will be measured in early 2015 using a dynamic plume tracer dispersion method (Mønster et al. 2014). A refined source attribution methodology together with more measurements and simulations of the N2O fluxes from the different land uses in this study site will provide a clearer view of the dynamics and budgets of N2O at the regional scale. The

  19. Trigonometry, Including Snell's Theorem.

    ERIC Educational Resources Information Center

    Kent, David

    1980-01-01

    Aspects of the instruction of trigonometry in secondary school mathematics are reviewed. Portions of this document cover basic introductions, a student-developed theorem, the cosine rule, inverse functions, and a sample outdoor activity. (MP)

  20. Laparoscopic Cytoreductive Surgery and HIPEC in Patients with Limited Pseudomyxoma Peritonei of Appendiceal Origin.

    PubMed

    Esquivel, Jesus; Averbach, Andrew

    2012-01-01

    Introduction. Increasing numbers of patients with pseudomyxoma peritonei (PMP) of appendiceal origin are being evaluated with a low tumor burden. We explored a minimally invasive approach for this group of patients. Materials and Methods. We designed a protocol in which patients with a PMP diagnosis would have a diagnostic laparoscopy. If limited carcinomatosis (PCI ≤ 10) is identified, the procedure will continue laparoscopically. If extensive carcinomatosis (PCI > 10) is found, then the procedure will be converted to an open approach. Results. From December 2008 to December 2011, 19 patients had a complete cytoreduction and HIPEC: 18 of them (95%) were done laparoscopically and 1 of them (5%) was converted to an open procedure. Mean PCI was 4.2. Grade 3 morbidity was 0, and one patient (5%) experienced a grade 4 complication, needing a reoperation for an internal hernia. There were no mortalities. Mean length of hospital stay was 5.3 days. At a mean follow-up of 17 months (1-37) all 19 patients are alive and free of disease. Conclusion. This study demonstrates that cytoreductive surgery and HIPEC via the laparoscopic route is feasible and safe and should be offered to patients with limited pseudomyxoma peritonei of appendiceal origin.

  1. 1992 Columbia River Salmon Flow Measures Options Analysis/EIS : Appendices.

    SciTech Connect

    Not Available

    1992-01-01

    This Options Analysis/Environmental Impact Statement (OA/EIS) identifies, presents effects of, and evaluates the potential options for changing instream flow levels in efforts to increase salmon populations in the lower Columbia and Snake rivers. The potential actions would be implemented during 1992 to benefit juvenile and adult salmon during migration through eight run-of-river reservoirs. The Corps of Engineers (Corps) prepared this document in cooperation with the Bonneville Power Administration and the Bureau of Reclamation. The US Fish and Wildlife Service (FWS) is a participating agency. The text and appendices of the document describe the characteristics of 10 Federal projects and one private water development project in the Columbia River drainage basin. Present and potential operation of these projects and their effects on the salmon that spawn and rear in the Columbia and Snake River System are presented. The life history, status, and response of Pacific salmon to current environmental conditions are described. The document concludes with an evaluation of the potential effects that could result from implementing proposed actions. The conclusions are based on evaluation of existing data, utilization of numerical models, and application of logical inference. This volume contains the appendices.

  2. Optimal application of Morrison's iterative noise removal for deconvolution. Appendices

    NASA Technical Reports Server (NTRS)

    Ioup, George E.; Ioup, Juliette W.

    1987-01-01

    Morrison's iterative method of noise removal, or Morrison's smoothing, is applied in a simulation to noise-added data sets of various noise levels to determine its optimum use. Morrison's smoothing is applied for noise removal alone, and for noise removal prior to deconvolution. For the latter, an accurate method is analyzed to provide confidence in the optimization. The method consists of convolving the data with an inverse filter calculated by taking the inverse discrete Fourier transform of the reciprocal of the transform of the response of the system. Various length filters are calculated for the narrow and wide Gaussian response functions used. Deconvolution of non-noisy data is performed, and the error in each deconvolution calculated. Plots are produced of error versus filter length; and from these plots the most accurate length filters determined. The statistical methodologies employed in the optimizations of Morrison's method are similar. A typical peak-type input is selected and convolved with the two response functions to produce the data sets to be analyzed. Both constant and ordinate-dependent Gaussian distributed noise is added to the data, where the noise levels of the data are characterized by their signal-to-noise ratios. The error measures employed in the optimizations are the L1 and L2 norms. Results of the optimizations for both Gaussians, both noise types, and both norms include figures of optimum iteration number and error improvement versus signal-to-noise ratio, and tables of results. The statistical variation of all quantities considered is also given.

  3. Characterization of Class A low-level radioactive waste 1986--1990. Volume 7: Appendices K--P

    SciTech Connect

    Dehmel, J.C.; Loomis, D.; Mauro, J.; Kaplan, M.

    1994-01-01

    Under contract to the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, the firms of S. Cohen & Associates, Inc. (SC&A) and Eastern Research Group (ERG) have compiled a report that describes the physical, chemical, and radiological properties of Class-A low-level radioactive waste. The report also presents information characterizing various methods and facilities used to treat and dispose non-radioactive waste. A database management program was developed for use in accessing, sorting, analyzing, and displaying the electronic data provided by EG&G. The program was used to present and aggregate data characterizing the radiological, physical, and chemical properties of the waste from descriptions contained in shipping manifests. The data thus retrieved are summarized in tables, histograms, and cumulative distribution curves presenting radionuclide concentration distributions in Class-A waste as a function of waste streams, by category of waste generators, and regions of the United States. The report also provides information characterizing methods and facilities used to treat and dispose non-radioactive waste, including industrial, municipal, and hazardous waste regulated under Subparts C and D of the Resource Conservation and Recovery Act (RCRA). The information includes a list of disposal options, the geographical locations of the processing and disposal facilities, and a description of the characteristics of such processing and disposal facilities. Volume 1 contains the Executive Summary, Volume 2 presents the Class-A waste database, Volume 3 presents the information characterizing non-radioactive waste management practices and facilities, and Volumes 4 through 7 contain Appendices A through P with supporting information.

  4. Characterization of Class A low-level radioactive waste 1986--1990. Volume 6: Appendices G--J

    SciTech Connect

    Dehmel, J.C.; Loomis, D.; Mauro, J.; Kaplan, M.

    1994-01-01

    Under contract to the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, the firms of S. Cohen & Associates, Inc. (SC&A) and Eastern Research Group (ERG) have compiled a report that describes the physical, chemical, and radiological properties of Class-A low-level radioactive waste. The report also presents information characterizing various methods and facilities used to treat and dispose non-radioactive waste. A database management program was developed for use in accessing, sorting, analyzing, and displaying the electronic data provided by EG&G. The program was used to present and aggregate data characterizing the radiological, physical, and chemical properties of the waste from descriptions contained in shipping manifests. The data thus retrieved are summarized in tables, histograms, and cumulative distribution curves presenting radionuclide concentration distributions in Class-A waste as a function of waste streams, by category of waste generators, and regions of the United States. The report also provides information characterizing methods and facilities used to treat and dispose non-radioactive waste, including industrial, municipal, and hazardous waste regulated under Subparts C and D of the Resource Conservation and Recovery Act (RCRA). The information includes a list of disposal options, the geographical locations of the processing and disposal facilities, and a description of the characteristics of such processing and disposal facilities. Volume 1 contains the Executive Summary, Volume 2 presents the Class-A waste database, Volume 3 presents the information characterizing non-radioactive waste management practices and facilities, and Volumes 4 through 7 contain Appendices A through P with supporting information.

  5. Crew Exploration Vehicle (CEV) (Orion) Occupant Protection. [Appendices Part 2

    NASA Technical Reports Server (NTRS)

    Currie-Gregg, Nancy J.; Gernhardt, Michael L.; Lawrence, Charles; Somers, Jeffrey T.

    2016-01-01

    The purpose of this study was to determine the similarity between the response of the THUMS model and the Hybrid III Anthropometric Test Device (ATD) given existing Wright-Patterson (WP) sled tests. There were four tests selected for this comparison with frontal, spinal, rear, and lateral loading. The THUMS was placed in a sled configuration that replicated the WP configuration and the recorded seat acceleration for each test was applied to model seat. Once the modeling simulations were complete, they were compared to the WP results using two methods. The first was a visual inspection of the sled test videos compared to the THUMS d3plot files. This comparison resulted in an assessment of the overall kinematics of the two results. The other comparison was a comparison of the plotted data recorded for both tests. The metrics selected for comparison were seat acceleration, belt forces, head acceleration and chest acceleration. These metrics were recorded in all WP tests and were outputs of the THUMS model. Once the comparison of the THUMS to the WP tests was complete, the THUMS model output was also examined for possible injuries in these scenarios. These outputs included metrics for injury risk to the head, neck, thorax, lumbar spine and lower extremities. The metrics to evaluate head response were peak head acceleration, HIC15, and HIC36. For the neck, N (sub ij) was calculated. The thorax response was evaluated with peak chest acceleration, the Combined Thoracic Index (CTI), sternal deflection, chest deflection, and chest acceleration- 3 ms clip. The lumbar spine response was evaluated with lumbar spine force. Finally the lower extremity response was evaluated by femur and tibia force. The results of the simulation comparisons indicate the THUMS model had a similar response to the Hybrid III dummy given the same input. The primary difference seen between the two was a more flexible response of the THUMS compared to the Hybrid III. This flexibility was most

  6. FIELD EVALUATION OF LOW-EMISSION COAL BURNER TECHNOLOGY ON UTILITY BURNERS VOLUME V. BURNER EVALUATION DATA APPENDICES

    EPA Science Inventory

    The report gives a detailed summary of data which were generated during the testing of experimental burners on EPA's Large Watertube Simulator (LWS) test facility. The test data are presented as a series of appendices. Appendix A describe the data quality assurance procedures whi...

  7. Comprehensive data base of high-level nuclear waste glasses: September 1987 status report: Volume 2, Additional appendices

    SciTech Connect

    Kindle, C.H.; Kreiter, M.R.

    1987-12-01

    The Materials Characterization Center (MCC) is assembling a comprehensive data base (CDB) of experimental data collected for high-level nuclear waste package components. The status of the CDB is summarized in Volume I of this report. Volume II contains appendices that present data from the data base and an evaluation of glass durability models applied to the data base.

  8. New York City School Survey 2008-2010: Assessing the Reliability and Validity of a Progress Report Measure. Technical Appendices

    ERIC Educational Resources Information Center

    Nathanson, Lori; Cole, Rachel; Kemple, James J.; Lent, Jessica; McCormick, Meghan; Segeritz, Micha

    2013-01-01

    The Research Alliance for New York City Schools examined Department of Education (DOE) School Survey data from 2008-2010 to better understand the richness and complexities of the information elicited by the Survey from parents, students, and teachers. This document provides the appendices to the technical report "New York City School Survey…

  9. Indian Economic Development: An Evaluation of EDA's Selected Indian Reservation Program. Volume II: Individual Reservation Reports, Appendices.

    ERIC Educational Resources Information Center

    Boise Cascade Center for Community Development, ID.

    As the appendices to an evaluation of the Economic Development Administration's (EDA) Selected Indian Reservation Program, this portion of the evaluation report presents individualized evaluations of each of the 16 reservations originally selected for the program in 1967. Each reservation evaluation is presented in terms of the following format:…

  10. SIGI: Field Test and Evaluation of a Computer-Based System of Interactive Guidance and Information. Volume II: Appendices.

    ERIC Educational Resources Information Center

    Chapman, Warren; And Others

    The computer-based System of Interactive Guidance and Information (SIGI) was field tested and evaluated at five community colleges and one university. Developed by Educational Testing Service, SIGI assists students in the process of informed and rational career decision making. These appendices to the final evaluation report contain the manuals…

  11. 31 CFR 501.807 - Procedures governing removal of names from appendices A, B, and C to this chapter.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Procedures governing removal of names from appendices A, B, and C to this chapter. 501.807 Section 501.807 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF...

  12. Including Jews in Multiculturalism.

    ERIC Educational Resources Information Center

    Langman, Peter F.

    1995-01-01

    Discusses reasons for the lack of attention to Jews as an ethnic minority within multiculturalism both by Jews and non-Jews; why Jews and Jewish issues need to be included; and addresses some of the issues involved in the ethical treatment of Jewish clients. (Author)

  13. Catalog of infrared observations including: Bibliography of infrared astronomy and index of infrared source positions

    NASA Technical Reports Server (NTRS)

    Gezari, D. Y.; Schmitz, M.; Mead, J. M.

    1984-01-01

    The Catalog of Infrared Observations and its Far Infrared Supplement summarize all infrared astronomical observations at infrared wavelengths published in the scientific literature between 1965 and 1982. The Catalog includes as appendices the Bibliography of infrared astronomy which keys observations in the Catalog with the original journal references, and the index of infrared source positions which gives source positions for alphabetically listed sources in the Catalog. The Catalog data base contains over 85,000 observations of about 10,000 infrared sources, of which about 2,000 have no known visible counterpart.

  14. Electric and Magnetic Fields (EMF) RAPID Program Engineering Project 8: FINAL REPORT, Evaluation of Field Reduction Technologies, Volume 1 (Report) and Volume 2 (Appendices)

    SciTech Connect

    Commonwealth Associates, Inc.; IIT Research Institute

    1997-08-01

    This draft report consists of two volumes. Volume 1, the main body, contains an introducto~ sectionj an overview of magnetic fields sectio~ and field reduction technology evaluation section. Magnetic field reduction methods are evalpated for transmission lines, distribution Iines,sulxtations, building wiring applkmd machinery, and transportation systems. The evaluation considers effectiveness, co% and other ftiors. Volume 2 contains five appendices, Append~ A presents magnetic field shielding information. Appendices B and C present design assumptions and magnetic field plots for transmission and distribution lines, respectively. Appendices D and E present cost estimate details for transmission and distribution limes, respectively.

  15. Light, Including Ultraviolet

    PubMed Central

    Maverakis, Emanual; Miyamura, Yoshinori; Bowen, Michael P.; Correa, Genevieve; Ono, Yoko; Goodarzi, Heidi

    2009-01-01

    Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory pathways leading to allergy or autoimmunity. In others, this same UV radiation can be used as a phototherapy to suppress pathogenic cutaneous immune responses. These vastly different properties are a direct result of UV light’s ability to ionize molecules in the skin and thereby chemically alter them. Sometimes these UV-induced chemical reactions are essential, the formation of pre-vitamin D3 from 7-dehydrocholesterol, for example. In other instances they can be potentially detrimental. UV radiation can ionize a cell’s DNA causing adjacent pyrimidine bases to chemically bond to each other. To prevent malignant transformation, a cell may respond to this UV-induced DNA damage by undergoing apoptosis. Although this pathway prevents skin cancer it also has the potential of inducing or exacerbating autoreactive immune responses by exposing the cell’s nuclear antigens. Ultaviolet-induced chemical reactions can activate the immune system by a variety of other mechanisms as well. In response to UV irradiation keratinocytes secrete cytokines and chemokines, which activate and recruit leukocytes to the skin. In some individuals UV-induced chemical reactions can synthesize novel antigens resulting in a photoallergy. Alternatively, photosensitizing molecules can damage cells by initiating sunburn-like phototoxic reactions. Herein we review all types of UV-induced skin reactions, especially those involving the immune system. PMID:20018479

  16. Iodine-131 Releases from Radioactive Lanthanum Processing at the X-10 Site in Oak Ridge, Tennessee (1944-1956)- An Assessment of Quantities released, Off-Site Radiation Doses, and Potential Excess Risks of Thyroid Cancer- APPENDICES Appendices-Volume 1A

    SciTech Connect

    Apostoaei, A.I.; Burns, R.E.; Hoffman, F.O.; Ijaz, T.; Lewis, C.J.; Nair, S.K.; Widner, T.E.

    1999-07-01

    This report consists of all the appendices for the report described below: In the early 1990s, concern about the Oak Ridge Reservation's past releases of contaminants to the environment prompted Tennessee's public health officials to pursue an in-depth study of potential off-site health effects at Oak Ridge. This study, the Oak Ridge dose reconstruction, was supported by an agreement between the U.S. Department of Energy (DOE) and the State of Tennessee, and was overseen by a 12-member panel appointed by Tennessee's Commissioner of Health. One of the major contaminants studied in the dose reconstruction was radioactive iodine, which was released to the air by X-10 (now called Oak Ridge National Laboratory) as it processed spent nuclear reactor fuel from 1944 through 1956. The process recovered radioactive lanthanum for use in weapons development. Iodine concentrates in the thyroid gland so health concerns include various diseases of the thyroid, such as thyroid cancer. The large report, ''Iodine-131 Releases from Radioactive Lanthanum Processing at the X-10 Site in Oak Ridge, Tennessee (1944-1956) - An Assessment of Quantities Released, Off-site Radiation Doses, and Potential Excess Risks of Thyroid Cancer,'' is in two volumes. Volume 1 is the main body of the report, and Volume 1A, which has the same title, consists of 22 supporting appendices. Together, these reports serve the following purposes: (1) describe the methodologies used to estimate the amount of iodine-131 (I-131) released; (2) evaluate I-131's pathway from air to vegetation to food to humans; (3) estimate doses received by human thyroids; (4) estimate excess risk of acquiring a thyroid cancer during ones lifetime; and (5) provide equations, examples of historical documents used, and tables of calculated values as appendices. Results indicate that females born in 1952 who consumed milk from a goat pastured a few miles east of X-10 received the highest doses from I-131 and would have had the highest

  17. Guide for Operational Configuration Management Program including the adjunct programs of design reconstitution and material condition and aging management. Part 2

    SciTech Connect

    Not Available

    1993-11-01

    This standard presents program criteria and implementation guidance for an operational configuration management program for DOE nuclear and non-nuclear facilities. This Part 2 includes chapters on implementation guidance for operational configuration management, implementation guidance for design reconstitution, and implementation guidance for material condition and aging management. Appendices are included on design control, examples of design information, conduct of walkdowns, and content of design information summaries.

  18. Nutritional therapies (including fosteum).

    PubMed

    Nieves, Jeri W

    2009-03-01

    Nutrition is important in promoting bone health and in managing an individual with low bone mass or osteoporosis. In adult women and men, known losses of bone mass and microarchitecture occur, and nutrition can help minimize these losses. In every patient, a healthy diet with adequate protein, fruits, vegetables, calcium, and vitamin D is required to maintain bone health. Recent reports on nutritional remedies for osteoporosis have highlighted the importance of calcium in youth and continued importance in conjunction with vitamin D as the population ages. It is likely that a calcium intake of 1200 mg/d is ideal, and there are some concerns about excessive calcium intakes. However, vitamin D intake needs to be increased in most populations. The ability of soy products, particularly genistein aglycone, to provide skeletal benefit has been recently studied, including some data that support a new medical food marketed as Fosteum (Primus Pharmaceuticals, Scottsdale, AZ).

  19. Waste-Management Education and Research Consortium (WERC) annual progress report, 1992--1993. Appendices

    SciTech Connect

    Not Available

    1993-02-15

    This report contains the following appendices: Appendix A - Requirements for Undergraduate Level; Appendix B - Requirements for Graduate Level; Appendix C - Graduate Degree In Environmental Engineeringat New Mexico State University; Appendix D - Non-degree Certificate program; Appendix E - Curriculum for Associate Degree Program in Radioactive & Hazardous Waste Materials; Appendix F - Curriculum for NCC Program in Earth & Environmental Sciences; Appendix G - Brochure of 1992 Teleconference Series; Appendix H - Sites for Hazardous/Radioactive Waste Management Series; Appendix I - WERC Interactive Television Courses; Appendix J - WERC Research Seminar Series Brochures; Appendix K - Summary of Technology Development of the Third Year; Appendix L - List of Major Publications Resulting From WERC; Appendix M - Types of Equipment at WERC Laboratories; and Appendix N - WERC Newsletter Examples.

  20. [Appendiceal orifice inflammation in distal ulcerative colitis. Report of a case and review of the literature].

    PubMed

    Tagle, Martin; Scavino, Yolanda; Luna, Eduardo

    2010-01-01

    We report the case of a 45-year-old female patient with an 18 month diagnosis of distal ulcerative colitis (proctosigmoiditis) of 18 months, who presented initially with allergy to salicylates, for which the disease was managed with corticosteroids and azathioprine and subsequently with Infliximab infusions, entering in remission. When she was about to receive her fifth Infliximab infusion she presented an exacerbation of her underlying disease with frequent stools with mucus, blood and tenesmus. Given that her initial diagnosis was made with a sigmoidoscopy we scheduled a total colonoscopy showing marked inflammation, erythema and friability limited to the recto-sigmoid mucosa, like at the disease onset, and when we reached the cecum an erythematous area circumscribed to the appendiceal orifice was observed, with a mucosal aspect identical to the described for the recto-sigmoid mucosa. The biopsies taken from that area were compatible with ulcerative colitis. We herein describe the details of the case and review the literature.

  1. US Fish and Wildlife Service biomonitoring operations manual, Appendices A--K

    SciTech Connect

    Gianotto, D.F.; Rope, R.C.; Mondecar, M.; Breckenridge, R.P.; Wiersma, G.B.; Staley, C.S.; Moser, R.S.; Sherwood, R.; Brown, K.W.

    1993-04-01

    Volume 2 contains Appendices and Summary Sheets for the following areas: A-Legislative Background and Key to Relevant Legislation, B- Biomonitoring Operations Workbook, C-Air Monitoring, D-Introduction to the Flora and Fauna for Biomonitoring, E-Decontamination Guidance Reference Field Methods, F-Documentation Guidance, Sample Handling, and Quality Assurance/Quality Control Standard Operating Procedures, G-Field Instrument Measurements Reference Field Methods, H-Ground Water Sampling Reference Field Methods, I-Sediment Sampling Reference Field Methods, J-Soil Sampling Reference Field Methods, K-Surface Water Reference Field Methods. Appendix B explains how to set up strategy to enter information on the ``disk workbook``. Appendix B is enhanced by DE97006389, an on-line workbook for users to be able to make revisions to their own biomonitoring data.

  2. Pre-operative Identification and Surgical Management of the Appendiceal Mucocele: A Case Report.

    PubMed

    Lynch, Kevin; Cho, Sung; Andres, Robert; Knight, Jennifer; Con, Jorge

    2016-01-01

    An appendiceal mucocele (AM) is an uncommon differential in the patient being evaluated for acute appendicitis. Although often asymptomatic, AMs can clinically mimic acute appendicitis, and preoperative distinction between these processes facilitates optimal management. We report the case of a 60-year-old male with an AM presenting with nausea and periumbilical pain radiating to the right lower quadrant. Literature relevant to the diagnosis and treatment of AMs is reviewed, with emphasis on diagnosis through radiographic imaging and surgical management. Abdominal CT scan or ultrasound are useful in identifying AMs preoperatively. A decision to perform a right hemicolectomy should be influenced by the criteria reported by Gonzalez-Moreno. The safety of the laparoscopic resection relative to an open appendectomy is debated.

  3. SunLine Transit Agency Advanced Technology Fuel Cell Bus Evaluation: Second Results Report and Appendices

    SciTech Connect

    Eudy, L.; Chandler, K.

    2011-10-01

    This report describes operations at SunLine Transit Agency for their newest prototype fuel cell bus and five compressed natural gas (CNG) buses. In May 2010, SunLine began operating its sixth-generation hydrogen fueled bus, an Advanced Technology (AT) fuel cell bus that incorporates the latest design improvements to reduce weight and increase reliability and performance. The agency is collaborating with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) to evaluate the bus in revenue service. This is the second results report for the AT fuel cell bus since it was placed in service, and it focuses on the newest data analysis and lessons learned since the previous report. The appendices, referenced in the main report, provide the full background for the evaluation. They will be updated as new information is collected but will contain the original background material from the first report.

  4. Simulation Framework for Rapid Entry, Descent, and Landing (EDL) Analysis. Volume 2; Appendices

    NASA Technical Reports Server (NTRS)

    Murri, Daniel G.

    2010-01-01

    The NASA Engineering and Safety Center (NESC) was requested to establish the Simulation Framework for Rapid Entry, Descent, and Landing (EDL) Analysis assessment, which involved development of an enhanced simulation architecture using the Program to Optimize Simulated Trajectories II (POST2) simulation tool. The assessment was requested to enhance the capability of the Agency to provide rapid evaluation of EDL characteristics in systems analysis studies, preliminary design, mission development and execution, and time-critical assessments. Many of the new simulation framework capabilities were developed to support the Agency EDL Systems Analysis (EDL-SA) team, that is conducting studies of the technologies and architectures that are required to enable higher mass robotic and human mission to Mars. The appendices to the original report are contained in this document.

  5. Evaluation of the Criterion Task Set. Part 1. Appendices A and B. Univariate Summaries

    DTIC Science & Technology

    1990-01-01

    Appendices A and B - Univariate Summaries (U) 12. PERSON~i. AUTHOR(S) Schlegel, Robert E. Ph.D. and Gilliland, Kirby Ph.D. 134, TYPE OF REPORT 1b. TIMRE...AISTRAC Cosnea eEef eEeyi fy by blok fut) " This report summarites the’dtevelopment and analysis of a comprehensive standardization data base for tho USAF...190.758 CSS 4.3908T CV 15.3807 STD MEAN 0.00853542 T:MEAN=O 1019T95 PROB>ITI 0.0001 SGN RAMiE 15190.5 PROB)ISI 0.0001 NUM 0 46 O:NORfAL 0.190657 PROO>D

  6. Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases

    PubMed Central

    Reid, Michelle D; Basturk, Olca; Shaib, Walid L; Xue, Yue; Balci, Serdar; Choi, Hye-Jeong; Akkas, Gizem; Memis, Bahar; Robinson, Brian S; El-Rayes, Bassel F; Staley, Charles A; Staley, Christopher A; Winer, Joshua H; Russell, Maria C; Knight, Jessica H; Goodman, Michael; Krasinskas, Alyssa M; Adsay, Volkan

    2016-01-01

    High-grade versions of appendiceal goblet cell carcinoids (‘adenocarcinoma ex-goblet cell carcinoids’) are poorly characterized. We herein document 77 examples. Tumors occurred predominantly in females (74%), mean age 55 years (29–84), most with disseminated abdominal (77% peritoneal, 58% gynecologic tract involvement) and stage IV (65%) disease. Many presented to gynecologic oncologists, and nine had a working diagnosis of ovarian carcinoma. Metastases to liver (n =3) and lung (n =1) were uncommon and none arose in adenomatous lesions. Tumors had various histologic patterns, in variable combinations, most of which were fairly specific, making them recognizable as appendiceal in origin, even at metastatic sites: I: Ordinary goblet cell carcinoid/crypt pattern (rounded, non-luminal acini with well-oriented goblet cells), in variable amounts in all cases. II: Poorly cohesive goblet cell pattern (diffusely infiltrative cords/single files of signet ring-like/goblet cells). III: Poorly cohesive non-mucinous cell (diffuse-infiltrative growth of non-mucinous cells). IV: Microglandular (rosette-like glandular) pattern without goblet cells. V: Mixed ‘other’ carcinoma foci (including ordinary intestinal/mucinous). VI: goblet cell carcinoid pattern with high-grade morphology (marked nuclear atypia). VII: Solid sheet-like pattern punctuated by goblet cells/microglandular units. Ordinary nested/trabecular (‘carcinoid pattern’) was very uncommon. In total, 33(52%) died of disease, with median overall survival 38 months and 5-year survival 32%. On multivariate analysis perineural invasion and younger age (<55) were independently associated with worse outcome while lymph-vascular invasion, stage, and nodal status trended toward, but failed to reach, statistical significance. Worse behavior in younger patients combined with female predilection and ovarian-affinity raise the possibility of hormone-assisted tumor progression. In conclusion, ‘adenocarcinoma ex

  7. Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases.

    PubMed

    Reid, Michelle D; Basturk, Olca; Shaib, Walid L; Xue, Yue; Balci, Serdar; Choi, Hye-Jeong; Akkas, Gizem; Memis, Bahar; Robinson, Brian S; El-Rayes, Bassel F; Staley, Charles A; Staley, Christopher A; Winer, Joshua H; Russell, Maria C; Knight, Jessica H; Goodman, Michael; Krasinskas, Alyssa M; Adsay, Volkan

    2016-10-01

    High-grade versions of appendiceal goblet cell carcinoids ('adenocarcinoma ex-goblet cell carcinoids') are poorly characterized. We herein document 77 examples. Tumors occurred predominantly in females (74%), mean age 55 years (29-84), most with disseminated abdominal (77% peritoneal, 58% gynecologic tract involvement) and stage IV (65%) disease. Many presented to gynecologic oncologists, and nine had a working diagnosis of ovarian carcinoma. Metastases to liver (n=3) and lung (n=1) were uncommon and none arose in adenomatous lesions. Tumors had various histologic patterns, in variable combinations, most of which were fairly specific, making them recognizable as appendiceal in origin, even at metastatic sites: I: Ordinary goblet cell carcinoid/crypt pattern (rounded, non-luminal acini with well-oriented goblet cells), in variable amounts in all cases. II: Poorly cohesive goblet cell pattern (diffusely infiltrative cords/single files of signet ring-like/goblet cells). III: Poorly cohesive non-mucinous cell (diffuse-infiltrative growth of non-mucinous cells). IV: Microglandular (rosette-like glandular) pattern without goblet cells. V: Mixed 'other' carcinoma foci (including ordinary intestinal/mucinous). VI: goblet cell carcinoid pattern with high-grade morphology (marked nuclear atypia). VII: Solid sheet-like pattern punctuated by goblet cells/microglandular units. Ordinary nested/trabecular ('carcinoid pattern') was very uncommon. In total, 33(52%) died of disease, with median overall survival 38 months and 5-year survival 32%. On multivariate analysis perineural invasion and younger age (<55) were independently associated with worse outcome while lymph-vascular invasion, stage, and nodal status trended toward, but failed to reach, statistical significance. Worse behavior in younger patients combined with female predilection and ovarian-affinity raise the possibility of hormone-assisted tumor progression. In conclusion, 'adenocarcinoma ex-goblet cell carcinoid' is

  8. Contrast-enhanced ultrasound improves accurate identification of appendiceal mucinous adenocarcinoma in an old patient

    PubMed Central

    Shang, Jing; Ruan, Li-tao; Dang, Ying; Wang, Yun-yue; Song, Yan; Lian, Jie

    2016-01-01

    Abstract Background: Adenocarcinoma of appendiceal origin is far rarer than other colorectal carcinomas and its preoperative diagnosis is challenging. To our knowledge, utility of contrast-enhanced ultrasound (CEUS) to diagnose it is much less. Method: A 61-year-old man presented with abdominal pain in the right lower quadrant for 20 days. In order to fulfill an accurately preoperative diagnosis, he received laboratory and imaging tests such as carcinoembryonic antigen (CEA), computer tomography (CT), CEUS and endoscope. Diagnosis and Intervention: He was initially suspected of suffering appendicitis, while his white blood cell count was normal and carcinoembryonic antigen (CEA) in serum was remarkably increased. Both routine ultrasound and computer tomography (CT) examinations supported suppurative appendicitis. The overall data, however, failed to excluded neoplastic pathology thoroughly. Therefore, CEUS was carried out and showed an inhomogeneous enhancement intra the lesion located in the body of the appendix, which made our consideration of neoplasm. The result of the follow-up biopsy guided by endoscope was consistent with appendiceal tumor. The patient received laparoscopic right hemicolectomy. Histopathology confirmed as well differentiated mucinous adenocarcinoma of appendix origin. His postoperative course was uneventful, and he had a regular diet again without any complaint. Result: Serum CEA was remarkably increased (12.00 ng/mL). Both routine ultrasound and CT examinations supported suppurative appendicitis. However, CEUS examination showed an inhomogeneous enhancement intra the lesion located in the body of the appendix, which made our consideration of neoplasm. The follow-up biopsy guided by endoscope and surgical specimens confirmed as well differentiated mucinous adenocarcinoma of appendix origin. Conclusion: Most mucinous adenocarcinoma mimicking appendicitis results in difficult diagnosis preoperatively. Clinician and radiologist should be

  9. Appendiceal mucinous neoplasms: an uncertain nosological entity. Report of a case

    PubMed Central

    AGRUSA, A.; ROMANO, G.; GALIA, M.; CUCINELLA, G.; SORCE, V.; DI BUONO, G.; GULOTTA, L.; AGNELLO, F.; AMATO, G.; GULOTTA, G.

    2016-01-01

    Introduction Appendiceal mucocele is a relatively rare condition characterized by progressive dilation of the appendix caused by intra-luminal accumulation of mucoid substance. Its incidence is 0.07 – 0,63% of all appendectomies performed. Case report We report the case of a 70-year-old man who came to our observation with gravative pain in right lower abdominal region. A computed tomography abdominal scan revealed a cystic/tubular structure like an appendicular mass with wall enhancement but without calcifications suggestive of a mucocele. Into peritoneal cavity we found profuse mucinous material with a 1,5 cm size parietal nodule. We also identified a free perforation of the cecum with consensual spillage of gelatinous material mimicking a pseudomyxoma peritonei. We decided to perform a right hemicolectomy with excision of peritoneal lesion. Discussion The controversy in the pathologic terminology can give rise to a clinical dilemma in terms of the management and follow-up plans. For mucosal hyperplasia and cystadenoma simple appendectomy is curative. Only in case of large base of implantation it may be necessary the resection of the ileum and caecum or right hemicolectomy. In case of mucinous cystoadenocarcinoma authors perform a right hemicolectomy. Conclusion Appendiceal mucinous neoplasms are different pathological entities. The correct surgical management depends on size and location of lesion. A preoperative diagnosis is obviously needed in order to perform the correct treatment. CT abdominal scan is the better diagnostic tool, but different authors show their inability to reach a preoperative diagnosis in the larger majority of cases. PMID:27381696

  10. The development of coal-based technologies for Department of Defense facilities. Volume 2, Appendices. Semiannual technical progress report, September 28, 1994--March 27, 1995

    SciTech Connect

    Miller, B.G.; Bartley, D.A.; Hatcher, P.

    1996-10-15

    This semiannual progress report contains the following appendices: description of the 1,000 lb steam/h watertube research boiler; the Pennsylvania CGE model; Phase II, subtask 3.9 coal market analysis; the CGE model; and sector definition.

  11. Field-scale investigation of enhanced petroleum hydrocarbon biodegradation in the vadose zone combining soil venting as an oxygen source with moisture and nutrient addition. Appendices. Doctoral thesis

    SciTech Connect

    Miller, R.N.

    1990-01-01

    This document contains appendices regarding a reprint on a field scale investigation of enhanced petroleum hydrocarbon biodegradation in the vadose zone combining soil venting as a oxygen source with moisture and nutrient addition.

  12. A study of toxic emissions from a coal-fired power plant: Niles Station Boiler No. 2. Volume 2, Appendices: Final report

    SciTech Connect

    Not Available

    1994-06-01

    Volume 2 contains appendices for: process data log sheets from Nile boiler 2; auditing; sampling protocol; field sampling data sheets; quality assurance/quality control; analytical protocol; and uncertainty analysis.

  13. Active Control of Radiated Sound with Integrated Piezoelectric Composite Structures. Volume 3: Appendices (Concl.)

    DTIC Science & Technology

    2007-11-02

    uncontrolled) adopting a similar control design using a MIMO feedforward natural frequency. In general, the controlled system corre- controller and a recursive...The effectiveness of this 16 R. A. Burdisso, C. R. Fuller, and Z. Li, "Eigenproperties of MIMO feed-formulation is demonstrated through numerical...would represent a impractical error sensing scheme and when the radiating structure is relatively massive . V. ACKNOWLEDGEMENTS The authors gratefully

  14. Active Control of Radiated Sound With Integrated Piezoelectric Composite Structures. Volume 2 Appendices (Concl.)

    DTIC Science & Technology

    2007-11-02

    were calculated u.mg their perimnental dat and Leo.realt=a calculations for bimorph actuators from the sme pi=oe!-ec’ic ceramics having the e dimensons...piezoelectric actuators to replace shak- rs obser toe sme ers and realize a more compact or "smart" structure. 3 radiate to the far field. One of the...Wk) (8) 9(k)=(ifrI(k) ifr 2(k) A ifrk(k)) (9) The cost function is constructed as the mean square error signal, i.e. = E[e2(k)] (10) Substituting

  15. Appendices for Fort George G. Meade Active Sanitary Landfill and Clean Fill Dump Remedial Investigation Report

    DTIC Science & Technology

    1992-12-01

    COPPER CUEXT * COPPER , EXTRACTABLE CtJTOT * COPPER , TOTAL CX PHOSGENE OXIME /DICULOROFORMOXIME CYDODC CYCLODODECANE CYHX YLHXN CYHXB CYCLOHEXYLBENZENE...RNX ENDRIN KETONE ENHETHETHYL-N-HEXYL ETHER ESFS04 ENDOSULFAN SULFATE ETBD10 ETHYLBENZENE-D1O ETCYHX ETHYLCYCLOHEXANE ETC6HS ETHY-LBENZENE ETOR...RDX CYCLOTRIKETHYLENETRINITRAMINE /CYCLONITE R.EDDY RED DYE RESCI*~RESNACIDS SB ANTIMONY SILVEX SILVEX SN TIN S03 SULFITE S04 SULFATE SPIRO (11’,5

  16. Refraction, including prisms.

    PubMed

    Hiatt, R L

    1991-02-01

    The literature in the past year on refraction is replete with several isolated but very important topics that have been of interest to strabismologists and refractionists for many decades. The refractive changes in scleral buckling procedures include an increase in axial length as well as an increase in myopia, as would be expected. Tinted lenses in dyslexia show little positive effect in the nonasthmatic patients in one study. The use of spectacles or bifocals as a way to control increase in myopia is refuted in another report. It has been shown that in accommodative esotropia not all patients will be able to escape the use of bifocals in the teenage years, even though surgery might be performed. The hope that disposable contact lenses would cut down on the instance of giant papillary conjunctivitis and keratitis has been given some credence, and the conventional theory that sclerosis alone is the cause of presbyopia is attacked. Also, gas permeable bifocal contact lenses are reviewed and the difficulties of correcting presbyopia by this method outlined. The practice of giving an aphakic less bifocal addition instead of a nonaphakic, based on the presumption of increased effective power, is challenged. In the review of prisms, the majority of articles concern prism adaption. The most significant report is that of the Prism Adaptation Study Research Group (Arch Ophthalmol 1990, 108:1248-1256), showing that acquired esotropia in particular has an increased incidence of stable and full corrections surgically in the prism adaptation group versus the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

  17. A Comprehensive Expression Analysis of Mucins in Appendiceal Carcinoma in a Multicenter Study: MUC3 Is a Novel Prognostic Factor

    PubMed Central

    Shibahara, Hiroaki; Higashi, Michiyo; Yokoyama, Seiya; Rousseau, Karine; Kitazono, Iwao; Osako, Masahiko; Shirahama, Hiroshi; Tashiro, Yukie; Kurumiya, Yasuhiro; Narita, Michihiko; Kuze, Shingo; Hasagawa, Hiroshi; Kato, Takehito; Kubota, Hitoshi; Suzuki, Hideaki; Arai, Toshiyuki; Sakai, Yu; Yuasa, Norihiro; Fujino, Masahiko; Kondo, Shinji; Okamoto, Yoshichika; Yamamoto, Tatsuyoshi; Hiromatsu, Takashi; Sasaki, Eiji; Shirai, Kazuhisa; Kawai, Satoru; Hattori, Koutarou; Tsuji, Hideki; Okochi, Osamu; Sakamoto, Masaki; Kondo, Akinobu; Konishi, Naomi; Batra, Surinder K.; Yonezawa, Suguru

    2014-01-01

    Background Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. Methods Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. Results The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p = 0.036); MUC2 with histological type (mucinous carcinoma, p<0.001), superficial invasion depth (p = 0.007), negative venous invasion (p = 0.003), and curative resection (p = 0.019); MUC3 with non-curative resection (p = 0.017); MUC5AC with histological type (mucinous carcinoma, p = 0.002), negative lymphatic invasion (p = 0.021), and negative venous invasion (p = 0.022); and MUC16 with positive lymph node metastasis (p = 0.035), positive venous invasion (p<0.05), and non-curative resection (p = 0.035). A poor prognosis was related to positive lymph node metastasis (p = 0.04), positive lymphatic invasion (p = 0.02), positive venous invasion (p<0.001), non-curative resection (p<0.001), and positive expression of MUC3 (p = 0.004). In multivariate analysis, positive venous invasion (HR: 6.93, 95% CI: 1.93–24.96, p = 0.003), non-curative resection (HR: 10.19, 95% CI: 3.05–34.07, p<0.001) and positive MUC3 expression (HR: 3.37, 95% CI: 1.13–10.03, p = 0.03) were identified as significant independent prognostic factors in patients with appendiceal carcinoma. Conclusions Expression of MUC3 in appendiceal carcinoma is an independent factor for poor prognosis and a useful predictor of outcome in patients with appendiceal carcinoma after

  18. A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.

    PubMed

    Carr, Norman J; Cecil, Thomas D; Mohamed, Faheez; Sobin, Leslie H; Sugarbaker, Paul H; González-Moreno, Santiago; Taflampas, Panos; Chapman, Sara; Moran, Brendan J

    2016-01-01

    Pseudomyxoma peritonei (PMP) is a complex disease with unique biological behavior that usually arises from appendiceal mucinous neoplasia. The classification of PMP and its primary appendiceal neoplasia is contentious, and an international modified Delphi consensus process was instigated to address terminology and definitions. A classification of mucinous appendiceal neoplasia was developed, and it was agreed that "mucinous adenocarcinoma" should be reserved for lesions with infiltrative invasion. The term "low-grade appendiceal mucinous neoplasm" was supported and it was agreed that "cystadenoma" should no longer be recommended. A new term of "high-grade appendiceal mucinous neoplasm" was proposed for lesions without infiltrative invasion but with high-grade cytologic atypia. Serrated polyp with or without dysplasia was preferred for tumors with serrated features confined to the mucosa with an intact muscularis mucosae. Consensus was achieved on the pathologic classification of PMP, defined as the intraperitoneal accumulation of mucus due to mucinous neoplasia characterized by the redistribution phenomenon. Three categories of PMP were agreed-low grade, high grade, and high grade with signet ring cells. Acellular mucin should be classified separately. It was agreed that low-grade and high-grade mucinous carcinoma peritonei should be considered synonymous with disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis, respectively. A checklist for the pathologic reporting of PMP and appendiceal mucinous neoplasms was also developed. By adopting the classifications and definitions that were agreed, different centers will be able to use uniform terminology that will allow meaningful comparison of their results.

  19. Activity.

    ERIC Educational Resources Information Center

    Clearing: Nature and Learning in the Pacific Northwest, 1984

    1984-01-01

    Presents three activities: (1) investigating succession in a schoolground; (2) investigating oak galls; and (3) making sun prints (photographs made without camera or darkroom). Each activity includes a list of materials needed and procedures used. (JN)

  20. Data requirements for EOR surfactant-polymer process simulation and analysis of El Dorado pilot-project simulation, Butler County, Kansas. Volume II. Appendices

    SciTech Connect

    Claridge, E.L.; Lohse, A.

    1983-01-01

    The results of computer simulation of the El Dorado surfactant-polymer EOR pilot project, Butler County, Kansas indicated that conventional data from the project and other data in the public domain were not adequate for geologic, reservoir and process characterizations in a complex numerical simulation. As used by GURC in geologic characterization, and by INTERCOMP in process characterization and input into the CFTE simulator, the collective body of field and chemical data and related assumptions necessary for simulator input was not sufficient to predict how the chemical flood would behave in the Admire 650-foot sandstone reservoir. Based upon this study, a comprehensive body of data requirements for EOR simulation is defined in detail. Geologic characterization includes descriptors for rock, interwell and intrasystem correlations; reservoir characterization includes descriptors for fluid/rock, production, and flow rate properties; process characterization includes descriptors for chemical properties, interactions and functions. Reservoir heterogeneity is a principal problem in EOR simulation. It can be overcome within reasonable economic limits by successive orders of descriptors from: microscale (rock), achieved through borehole and core analyses; to macroscale (interwell), achieved through multiple borehole correlations; to megascale (intrasystem), achieved through extrapolation of rock and correlative well data into a generic depositional model that contains a description of internal mass properties within a given external morphology. Volume II contains appendices for: flow chart for surfactant-polymer process simulation; INTERCOMP reports to GURC describing the CFTE simulator program used in this study.

  1. Appendiceal diverticulitis in a femoral hernia causing necrotizing fasciitis of the right inguinal region: report of a unique case.

    PubMed

    Georgiou, G K; Bali, C; Theodorou, S J; Zioga, A; Fatouros, M

    2013-02-01

    De Garengeot's hernia--a rare finding occurring mostly in women--is defined by the presence of the vermiform appendix within the sac of a femoral hernia. The incidence of appendicitis is rarer still, with less than a 100 cases reported to date. We present a unique case of an 84-year-old male patient with perforated appendiceal diverticulitis within a De Garengeot's hernia causing abscess and necrotizing infection of the overlying soft tissues.

  2. Pelletizing/reslurrying as a means of distributing and firing clean coal. Final quarterly technical progress report No. 7, Appendices

    SciTech Connect

    Not Available

    1992-06-09

    This volume contains appendices for: atomization test report; cost estimation model--pelletization material balance and equipment selection; cost estimation model--pelletization capital investment estimates; cost estimation--pelletization operating cost estimates; cost estimation model--pellet-CWF formulation material balance and equipment selection; cost estimation model--pellet-CWF capital investment estimates; cost estimation model--pellet-CWF operating cost estimates; and cost estimation model--direct CWF operating cost estimates.

  3. Prediction of Supersonic Store Separation Characteristics Including Fuselage and Stores of Noncircular Cross Section, Volume IV. Appendices C and D, Details of Program II.

    DTIC Science & Technology

    1980-11-01

    changed, if you wish to be removed from our mailing list, or if the addressee is no longer employed by your organization please notify AFWAL/FIGC , W...set up store and empennage models, organize calculation of store forces and moments, and set up and solve equations of motion for store trajectory 2...ADAMS numerical integration routine to integrate differential equations BDCOEF routine to organize generation of influence coef- ficient matrices for

  4. Automatic Traffic Advisory and Resolution Service (ATARS) Algorithms Including Resolution-Advisory-Register Logic. Volume 2. Sections 12 through 19. Appendices,

    DTIC Science & Technology

    1981-06-01

    resolutionadvisoryaddition for controlled_ air craft*, ILSf PERFOPM p siltiveneg ativeresolution advisory transition_ test; IF (resolution advisories have not...PPvC.acl.SEND ?.2 S-RUZ 21 PV1EC.ac2.SEWD LQ MUI) Tl~W .&L lPDTSECTOV1D IYU (ACIiII, ACID2, conflict table, * air record):. U(PIEC. HDOPP r& SVALSI Ln...ACIBS_? entry found with END status AIR next entry does not have same ICS_Trackno) yove subject entry after one with 119 status% Assign subject entry

  5. Prediction of Supersonic Store Separation Characteristics Including Fuselage and Stores of Noncircular Cross Section. Volume III. Appendices A and B, Details of Program I.

    DTIC Science & Technology

    1980-11-01

    IZPT,ITH,IDEL,NTAP7,IAR,IAN,IUB, IGB(7) ,IVB,IU,IV,IW,IVA,IWA, ICP, IPHI,IYB,NAG,NAP,NAV,NAS, NASHK, NAFLD ,IAO,IDO,ISKO,TYIMI,IZIM,ISVN,ISKP,NRING,IROW...locations in blank common required in SOLVE NASHIK maximum locations in blank common required in BSHOCK NAFLD maximum locations in blank common

  6. Georges Bank benthic infauna monitoring program. Final report for third year of sampling. Volume 3. Appendices

    SciTech Connect

    Maciolek-Blake, N.; Grassle, J.F.; Neff, J.M.

    1985-04-15

    Concerns about the potential effects of oil- and gas-exploration activities on Georges Bank led to the initiation of a monitoring program in July 1981. The program included sampling of the benthic communities near, upcurrent, and downcurrent of the drilling rigs, analysis of bottom photographs for epifauna and microtopography, trawl collections, total organic carbon and sediment grain size analysis. Additional aspects of the program included a detailed life history analysis of 23 dominant species, and a study which linked fish feeding with benthic production. No biological impacts that could be attributed to drilling activities were detected at any station.

  7. Update of the BIPM comparison BIPM.RI(II)-K1.Sr-85 of activity measurements of the radionuclide 85Sr to include the 2009 result of the POLATOM (Poland)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Dziel, T.; Listkowska, A.

    2015-01-01

    Since 1975, ten laboratories have submitted 27 samples of known activity of 85Sr to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Sr-85. The values of the activity submitted were between about 0.2 MBq and 19 MBq. The key comparison reference value (KCRV) has been recalculated to include the primary standardization result for the POLATOM, Poland. There are now four results in the BIPM.RI(II)-K1.Sr-85 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  8. Use of transportable storage casks in the nuclear waste management system: Appendices

    SciTech Connect

    Not Available

    1987-12-01

    A study was performed to determine the viability of the use of transportable storage casks (TSCs), and other metal casks that are designed primarily for storage but which might be used to ship their stored contents to DOE on a one-time use basis (referred to in this study as storage only casks, or SOCs), in the combined utility/DOE spent fuel management system. The viability of the use of TSCs and SOCs was assessed in terms of the costs and savings involved in their use, the sensitivity of these costs and savings to changes in the capacity and cost of fabrication of the casks, the impacts of variation in cask design features on cost and radiation exposure of personnel, and their prospective use in connection with the transport of defense high level wastes. Estimates were developed of the costs of acquiring and handling of TSCs and SOCs at reactor sites. For comparison purposes, similar costs were developed for the use of concrete storage casks at reactor sites. Estimates of the savings involved to the DOE system as a result of receiving spent fuel in TSCs or SOCs were separately developed. These costs are developed and presented in Volume 2, Appendices A through J.

  9. Analysis of core damage frequency: Peach Bottom, Unit 2 internal events appendices

    SciTech Connect

    Kolaczkowski, A.M.; Cramond, W.R.; Sype, T.T.; Maloney, K.J.; Wheeler, T.A.; Daniel, S.L.; Sandia National Labs., Albuquerque, NM )

    1989-08-01

    This document contains the appendices for the accident sequence analysis of internally initiated events for the Peach Bottom, Unit 2 Nuclear Power Plant. This is one of the five plant analyses conducted as part of the NUREG-1150 effort for the Nuclear Regulatory Commission. The work performed and described here is an extensive reanalysis of that published in October 1986 as NUREG/CR-4550, Volume 4. It addresses comments from numerous reviewers and significant changes to the plant systems and procedures made since the first report. The uncertainty analysis and presentation of results are also much improved, and considerable effort was expended on an improved analysis of loss of offsite power. The content and detail of this report is directed toward PRA practitioners who need to know how the work was done and the details for use in further studies. The mean core damage frequency is 4.5E-6 with 5% and 95% uncertainty bounds of 3.5E-7 and 1.3E-5, respectively. Station blackout type accidents (loss of all ac power) contributed about 46% of the core damage frequency with Anticipated Transient Without Scram (ATWS) accidents contributing another 42%. The numerical results are driven by loss of offsite power, transients with the power conversion system initially available operator errors, and mechanical failure to scram. 13 refs., 345 figs., 171 tabs.

  10. Solar Central Receiver Hybrid Power Systems sodium-cooled receiver concept. Final report. Volume III. Appendices

    SciTech Connect

    1980-01-01

    The overall, long term objective of the Solar Central Receiver Hybrid Power System is to identify, characterize, and ultimately demonstrate the viability and cost effectiveness of solar/fossil, steam Rankine cycle, hybrid power systems that: (1) consist of a combined solar central receiver energy source and a nonsolar energy source at a single, common site, (2) may operate in the base, intermediate, and peaking capacity modes, (3) produce the rated output independent of variations in solar insolation, (4) provide a significant savings (50% or more) in fuel consumpton, and (5) produce power at the minimum possible cost in mills/kWh. It is essential that these hybrid concepts be technically feasible and economically competitive with other systems in the near to mid-term time period (1985-1990) on a commercial scale. The program objective for Phase I is to identify and conceptually characterize solar/fossil steam Rankine cycle, commercial-scale, power plant systems that are economically viable and technically feasible. This volume contains appendices to the conceptual design and systems analysis studies gien in Volume II, Books 1 and 2. (WHK)

  11. Interim performance criteria for photovoltaic energy systems. [Glossary included

    SciTech Connect

    DeBlasio, R.; Forman, S.; Hogan, S.; Nuss, G.; Post, H.; Ross, R.; Schafft, H.

    1980-12-01

    This document is a response to the Photovoltaic Research, Development, and Demonstration Act of 1978 (P.L. 95-590) which required the generation of performance criteria for photovoltaic energy systems. Since the document is evolutionary and will be updated, the term interim is used. More than 50 experts in the photovoltaic field have contributed in the writing and review of the 179 performance criteria listed in this document. The performance criteria address characteristics of present-day photovoltaic systems that are of interest to manufacturers, government agencies, purchasers, and all others interested in various aspects of photovoltaic system performance and safety. The performance criteria apply to the system as a whole and to its possible subsystems: array, power conditioning, monitor and control, storage, cabling, and power distribution. They are further categorized according to the following performance attributes: electrical, thermal, mechanical/structural, safety, durability/reliability, installation/operation/maintenance, and building/site. Each criterion contains a statement of expected performance (nonprescriptive), a method of evaluation, and a commentary with further information or justification. Over 50 references for background information are also given. A glossary with definitions relevant to photovoltaic systems and a section on test methods are presented in the appendices. Twenty test methods are included to measure performance characteristics of the subsystem elements. These test methods and other parts of the document will be expanded or revised as future experience and needs dictate.

  12. Cost of Federal tax credit programs to develop the market for industrial solar and wind energy technologies. Final report to Lawrence Livermore Laboratory, University of California. Volume 2: appendices

    SciTech Connect

    Downey, W. T.; Carey, H.; Dlott, E.; Frantzis, L.; McDonald, M.; Myer, L.; O'Neill, K.; Patel, R.; Perkins, R.

    1981-11-12

    A study was made to estimate the impact tax credits (from Acts passed by Congress) would have on renewable energy investment and to estimate the net costs to the US Treasury of providing these tax credits. The appendices to this study are presented. Some investment and marketing penetration worksheets are presented on wind turbines, solar ponds, flat plates, evacuated tubes, and parabolic troughs. A market penetration and economic analysis program with test written for TI-59 programmable calculator with printer is presented. Data on the average $/kWh for each state are included for energy use (70 to 400/sup 0/F and electricity) and energy resource (total and direct solar and wind). Also included is an energy use processing program written for TI-59 programmable calculator with printer. (MCW)

  13. Synchronous Low-grade Appendiceal Mucinous Neoplasm and Primary Peritoneal Low-grade Serous Carcinoma: A First Description of These 2 Neoplasms Presenting Together as Suspected Peritoneal Carcinomatosis.

    PubMed

    Sekulic, Miroslav; Pichler Sekulic, Simona; Movahedi-Lankarani, Saeid

    2016-09-28

    Low-grade appendiceal mucinous neoplasm is a neoplasm typically of appendiceal origin, which is characterized by diffuse peritoneal involvement by pools of mucin with mucinous epithelium lacking high-grade cytologic atypia, and clinically presents as suspected peritoneal carcinomatosis. A similar clinical presentation can sometimes be seen with disseminated low-grade serous carcinomas of the peritoneum, fallopian tubes, or ovaries; however, this neoplasm is histologically characterized by tubal-type epithelium and invasive or confluent growth. In this case report, we describe a patient presenting with a clinical examination and radiologic features suggestive of peritoneal carcinomatosis and a prominent pelvic mass; however, after pathologic review, the patient was proven to have peritoneal involvement by both low-grade appendiceal mucinous neoplasm of appendiceal origin and a low-grade peritoneal primary serous carcinoma. In short, we present the first description of low-grade appendiceal mucinous neoplasm and serous carcinoma of the peritoneum presenting synchronously, providing morphologic characterization and immunohistochemical studies supporting the diagnosis, and illustrating a rare instance in which 2 neoplastic processes are underlying clinically suspected peritoneal carcinomatosis.

  14. Final safety evaluation report related to the certification of the System 80{sup +} design (Docket No. 52-002). Volume 2, Chapters 15--22 and appendices

    SciTech Connect

    Not Available

    1994-08-01

    This final safety evaluation report (FSER) documents the technical review of the System 80+ standard design by the US Nuclear Regulatory Commission (NRC) staff. The application for the system 80+ design was submitted by Combustion Engineering, Inc., now Asea Brown Boveri-Combustion Engineering (ABB-CE) as an application for design approval and subsequent design certification pursuant to 10 CFR {section} 52.45. System 80+ is a pressurized water reactor with a rated power of 3914 megawatts thermal (MWt) and a design power of 3992 MWt at which accidents are analyzed. Many features of the System 80+ are similar to those of ABB-CE`s System 80 design from which it evolved. Unique features of the System 80+ design include: a large spherical, steel containment; an in-containment refueling water storage tank; a reactor cavity flooding system, hydrogen ignitors and a safety depressurization system for severe accident mitigation; a combustion gas turbine for an alternate ac source; and an advanced digitally based control room. On the basis of its evaluation and independent analyses, the NRC staff concludes that ABB-CE`s application for design certification meets the requirements of Subpart B of 10 CFR Part 52 that are applicable and technically relevant to the System 80+ standard design. This document, Volume 2, contains Chapters 15 through 22 and Appendices A through E.

  15. Safety of high speed magnetic levitation transportation systems. Magnetic field testing of the TR07 Maglev vehicle and system. Volume 2: Appendices

    NASA Astrophysics Data System (ADS)

    Dietrich, Fred; Robertson, David; Steiner, George

    1992-04-01

    The safety of various magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is of direct concern to the Federal Railroad Administration (FRA). The characterization of electric and magnetic fields (EMF) emissions, both steady (dc) and produced by alternating current (ac) at power frequency (50 Hz in Europe and 60 Hz in the U.S.) and other frequencies in the Extreme Low Frequency (ELF) range (3-3000 Hz), and associated public and worker exposures to EMF, are a growing health and safety concern worldwide. As part of a comprehensive safety assessment of the German TransRapid (TR-07) maglev system undertaken by the FRA, with technical support from the DOT/RSPA Volpe National Transportation System Center (VNTSC), magnetic field measurements were performed by Electric Research and Management, Inc. (ERM) at the Transrapid Test Facility (TVE) in Emsland, Germany in August, 1990. Appendices include catalogs and documents detailing magnetic field data files and their specifics (static fields, spectral waveforms, and temporal and spatial information) by location.

  16. System-Cost-Optimized Smart EVSE for Residential Application: Final Technical Report including Manufacturing Plan

    SciTech Connect

    Zhu, Charles

    2015-05-15

    In the 2nd quarter of 2012, a program was formally initiated at Delta Products to develop smart-grid-enabled Electric Vehicle Supply Equipment (EVSE) product for residential use. The project was funded in part by the U.S. Department of Energy (DOE), under award DE-OE0000590. Delta products was the prime contractor to DOE during the three year duration of the project. In addition to Delta Products, several additional supplier-partners were engaged in this research and development (R&D) program, including Detroit Edison DTE, Mercedes Benz Research and Development North America, and kVA. This report summarizes the program and describes the key research outcomes of the program. A technical history of the project activities is provided, which describes the key steps taken in the research and the findings made at successive stages in the multi-stage work. The evolution of an EVSE prototype system is described in detail, culminating in prototypes shipped to Department of Energy Laboratories for final qualification. After the program history is reviewed, the key attributes of the resulting EVSE are described in terms of functionality, performance, and cost. The results clearly demonstrate the ability of this EVSE to meet or exceed DOE's targets for this program, including: construction of a working product-intent prototype of a smart-grid-enabled EVSE, with suitable connectivity to grid management and home-energy management systems, revenue-grade metering, and related technical functions; and cost reduction of 50% or more compared to typical market priced EVSEs at the time of DOE's funding opportunity announcement (FOA), which was released in mid 2011. In addition to meeting all the program goals, the program was completed within the original budget and timeline established at the time of the award. The summary program budget and timeline, comparing plan versus actual values, is provided for reference, along with several supporting explanatory notes. Technical information

  17. Impact of geothermal technology improvements on royalty collections on federal lands: Volume II: Appendices

    SciTech Connect

    Not Available

    1988-10-01

    This volume contains the appendices for the ''Impact of Geothermal Technology Improvements on Royalty Collections on Federal Lands, Final Report, Volume I.'' The material in this volume supports the conclusions presented in Volume I and details each Known Geothermal Resource Area's (KGRA's) royalty estimation. Appendix A details the physical characteristics of each KGRA considered in Volume I. Appendix B supplies summary narratives on each state which has a KGRA. The information presented in Appendix C shows the geothermal power plant area proxies chosen for each KGRA considered within the report. It also provides data ranges which fit into the IMGEO model for electric energy cost estimates. Appendix D provides detailed cost information from the IMGEO model if no Geothermal Program RandD goals were completed beyond 1987 and if all the RandD goals were completed by the year 2000. This appendix gives an overall electric cost and major system costs, which add up to the overall electric cost. Appendix E supplies information for avoided cost projections for each state involved in the study that were used in the IMGEO model run to determine at what cost/kWh a 50 MWe plant could come on line. Appendix F supplies the code used in the determination of royalty income, as well as, tabled results of the royalty runs (detailed in Appendix G). The tabled results show royalty incomes, assuming a 10% discount rate, with and without RandD and with and without a $0.01/kWh transmission cost. Individual data sheets for each KGRA royalty income run are presented in Appendix G.

  18. Probabilistic accident consequence uncertainty analysis: Dispersion and deposition uncertainty assessment, appendices A and B

    SciTech Connect

    Harper, F.T.; Young, M.L.; Miller, L.A.; Hora, S.C.; Lui, C.H.; Goossens, L.H.J.; Cooke, R.M.; Paesler-Sauer, J.; Helton, J.C.

    1995-01-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, completed in 1990, estimate the risks presented by nuclear installations based on postulated frequencies and magnitudes of potential accidents. In 1991, the US Nuclear Regulatory Commission (NRC) and the Commission of the European Communities (CEC) began a joint uncertainty analysis of the two codes. The objective was to develop credible and traceable uncertainty distributions for the input variables of the codes. Expert elicitation, developed independently, was identified as the best technology available for developing a library of uncertainty distributions for the selected consequence parameters. The study was formulated jointly and was limited to the current code models and to physical quantities that could be measured in experiments. To validate the distributions generated for the wet deposition input variables, samples were taken from these distributions and propagated through the wet deposition code model along with the Gaussian plume model (GPM) implemented in the MACCS and COSYMA codes. Resulting distributions closely replicated the aggregated elicited wet deposition distributions. Project teams from the NRC and CEC cooperated successfully to develop and implement a unified process for the elaboration of uncertainty distributions on consequence code input parameters. Formal expert judgment elicitation proved valuable for synthesizing the best available information. Distributions on measurable atmospheric dispersion and deposition parameters were successfully elicited from experts involved in the many phenomenological areas of consequence analysis. This volume is the second of a three-volume document describing the project and contains two appendices describing the rationales for the dispersion and deposition data along with short biographies of the 16 experts who participated in the project.

  19. Probabilistic accident consequence uncertainty analysis: Food chain uncertainty assessment. Volume 2: Appendices

    SciTech Connect

    Brown, J.; Goossens, L.H.J.; Kraan, B.C.P.

    1997-06-01

    This volume is the second of a two-volume document that summarizes a joint project by the US Nuclear Regulatory and the Commission of European Communities to assess uncertainties in the MACCS and COSYMA probabilistic accident consequence codes. These codes were developed primarily for estimating the risks presented by nuclear reactors based on postulated frequencies and magnitudes of potential accidents. This two-volume report, which examines mechanisms and uncertainties of transfer through the food chain, is the first in a series of five such reports. A panel of sixteen experts was formed to compile credible and traceable uncertainty distributions for food chain transfer that affect calculations of offsite radiological consequences. Seven of the experts reported on transfer into the food chain through soil and plants, nine reported on transfer via food products from animals, and two reported on both. The expert judgment elicitation procedure and its outcomes are described in these volumes. This volume contains seven appendices. Appendix A presents a brief discussion of the MAACS and COSYMA model codes. Appendix B is the structure document and elicitation questionnaire for the expert panel on soils and plants. Appendix C presents the rationales and responses of each of the members of the soils and plants expert panel. Appendix D is the structure document and elicitation questionnaire for the expert panel on animal transfer. The rationales and responses of each of the experts on animal transfer are given in Appendix E. Brief biographies of the food chain expert panel members are provided in Appendix F. Aggregated results of expert responses are presented in graph format in Appendix G.

  20. Using Appendiceal Perforation Rates to Measure Impact of a Disaster on Healthcare System Effectiveness

    PubMed Central

    Mack, Dominic; Rust, George Staben; Baltrus, Peter; Moore, Barbara; Sow, Charles; Patel, Vijaykumar; Thomas, Dwayne

    2015-01-01

    Objectives To understand baseline inequities in appendiceal perforation rates and the impact of hurricane destruction on the healthcare system with respect to perforation rates and racial disparities. Methods We used claims data extracted from Medicaid Analytic Extract files to identify appendicitis diagnoses in children and adolescents based on International Classification of Diseases-9 codes and appendectomy procedures based on Current Procedural Terminology codes in the hurricane-affected states of Mississippi and Louisiana. County-level summary data obtained from 2005 Area Resource Files were used to determine high and low hurricane-affected areas. We estimated logistic regression models, mutually adjusting for race, sex, and age, to examine disparities and mixed logistic regression models to determine whether county-level effects contributed to perforation rates. Results There were nine counties in the high-impact area and 133 counties in the low-impact area. Living in the high- or low-impact area was not associated with a statistically different rate of perforation before or after Hurricane Katrina; however, living in the high-impact area was associated with a change from a lower risk (odds ratio [OR] 0.62) of perforation prehurricane to a higher risk (OR 1.14) posthurricane compared with those living in the low-impact areas. African Americans had statistically higher perforation rates than whites in the high-impact areas both before (OR 1.46) and after (OR 1.71) Hurricane Katrina. Conclusions Health professionals and hospital systems were able to maintain effective levels of care before and after Hurricane Katrina; however, perforation rates in African Americans suggest ongoing racial disparities during disasters. PMID:23263319

  1. Program evaluation: Weatherization Residential Assistance Partnership (WRAP) Program. Volume 2, Appendices A, B, and C: [Final report

    SciTech Connect

    Not Available

    1991-12-01

    The ``Weatherization Residential Assistance Partnership,`` or WRAP program, is a fuel-blind conservation program designed to assist Northeast Utilities` low-income customers to use energy safely and efficiently. Innovative with respect to its collaborative approach and its focus on utilizing and strengthening the existing low-income weatherization service delivery network, the WRAP program offers an interesting model to other utilities which traditionally have relied on for-profit energy service contractors and highly centralized program implementation structures. This report presents appendices with energy savings, consumption and socio-economic data for low income population in both urban and rural areas.

  2. Hazardous-materials car placement in a train consist. Volume 2. Appendices. Final report, 18 Feb-17 Nov 88

    SciTech Connect

    Thompson, R.E.; Zamejc, E.R.; Ahlbeck, D.R.

    1992-06-01

    Appendices, Volume II consist of Appendix A. Form FRA F6180-54 (12-74) Rail Equipment Accident/Incident Report; Appendix B. Data Related to Derailment Analysis; Appendix C. Review of Selected Railroad Accidents Involving Multiple Hazardous Materials; Appendix D. U.S. Department of Transportation Hazmat Car Placement Regulations; Appendix E. Canadian Transport Commission Hazmat Car Placement Regulations; Appendix F. Hazardous Materials Definitions; Appendix G. Table of Position in Train Requirements; Appendix H. Chemical Reactivities of Binary Combinations; Appendix I. Results from the Consequence Calculations; Appendix J. Consequence and Risk Rankings of Incompatible Chemical Combinations.

  3. Program evaluation: Weatherization Residential Assistance Partnership (WRAP) Program. Volume 3, Appendices D, E, F, and G: [Final Report

    SciTech Connect

    Not Available

    1991-12-01

    The ``Weatherization Residential Assistance Partnership,`` or WRAP program, is a fuel-blind conservation program designed to assist Northeast Utilities` low-income customers to use energy safely and efficiently. Innovative with respect to its collaborative approach and its focus on utilizing and strengthening the existing low-income weatherization service delivery network, the WRAP program offers an interesting model to other utilities which traditionally have relied on for-profit energy service contractors and highly centralized program implementation structures. This report presents appendices with surveys, participant list, and computers program to examine and predict potential energy savings.

  4. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading. Volume 2, Part 1; Appendices

    NASA Technical Reports Server (NTRS)

    Gentz, Steven J.; Ordway, David O.; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.

    2015-01-01

    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (approximately 9 inches from the source) dominated by direct wave propagation, mid-field environment (approximately 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This document contains appendices to the Volume I report.

  5. Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation.

    PubMed

    Sáenz-de-Santa-María, Inés; Bernardo-Castiñeira, Cristóbal; Secades, Pablo; Bernaldo-de-Quirós, Sandra; Rodrigo, Juan Pablo; Astudillo, Aurora; Chiara, María-Dolores

    2017-01-13

    Metabolic reprogramming is a very heterogeneous phenomenon in cancer. It mostly consists on increased glycolysis, lactic acid formation and extracellular acidification. These events have been associated to increased activity of the hypoxia inducible factor, HIF-1α. This study aimed at defining the metabolic program activated by HIF-1α in oropharyngeal squamous cell carcinomas (SCC) and assessing its clinical impact. Global gene/miRNA expression was analyzed in SCC-derived cells exposed to hypoxia. Expression of HIF-1α, the carbonic anhydrase CAIX, and the lactate/H+ transporters MCT1 and MCT4 were analyzed by immunohistochemistry in 246 SCCs. Cell-based analysis revealed that HIF-1α-driven metabolic program includes over-expression of glycolytic enzymes and the microRNA miR-210 coupled to down-regulation of its target, the iron-sulfur cluster assembly protein, ISCU. pH-regulator program entailed over-expression of CAIX, but not MCT1 or MCT4. Accordingly, significant overlapping exists between over-expression of HIF-1α and CAIX, but not HIF-1α and MCT1 or MCT4, in tumor cells. Increased miR-210 and concomitant decreased ISCU RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1α and CAIX, but not MCT1 or MCT4, over-expression. HIF-1α and/or CAIX over-expression was associated with high recurrence rate and low overall survival of surgically treated patients. By contrast, clinically significant correlations were not found in tumors with MCT1 or MCT4 over-expression. This is the first study that provides in vivo evidences of coordinated activation of HIF-1α, CAIX, miR-210 and ISCU in carcinoma and association with poor prognosis, a finding with important implications for the development of metabolic-targeting therapies against hypoxia.

  6. Safety of high speed guided ground transportation systems: Magnetic and electric field testing of the Massachusetts Bay Transportation Authority (MBTA) urban transit system. Volume 2. Appendices. Final report, September 1992-March 1993

    SciTech Connect

    Jacobs, W.L.; Robertson, D.C.; Steiner, G.A.

    1993-06-01

    The safety of magnetically levitated (maglev) and high speed rail (HSR) trains proposed for application in the United States is the responsibility of the Federal Railroad Administration (FRA). Plans for near future US applications include maglev projects (e.g. in Orlando, FL and Pittsburgh, PA) and high speed rail (the French Train a Grande Vitesse (TGV) in the Texas Triangle). The report provides the Analysis (Vol. I) of results, and detailed data and statistical summaries (Vol. II, Appendices) of representative EMF profiles on vehicles and facilities typical of electrotechnologies used in the transit system (3rd rail dc, catenary with pantograph, trolley bus). Each electrotechnology has specific EMF frequency signatures. EMF data represent a range of system operating conditions and locations (in vehicles, stations and waysides), as well as traffic control and electrical power supply facilities.

  7. Town Brook Local Protection, Massachusetts Coastal Streams: Feasibility Report for Water Resources Development. Volume II. Appendices.

    DTIC Science & Technology

    1980-09-01

    and "typical" of heavy construction activities. These effects are increased noise, air pollition, dust and heavy truck traffic. Positive economic...and would include stream siltation, some added dust and noise, and the removal of small areas of trees or other onsite vegetation. Any vegetation...be sensitive to construction impacts, such as increased noise and dust levels, increased use of local roads and increased heavy truck traffic

  8. Toward the standard population synthesis model of the X-ray background: Evolution of X-ray luminosity and absorption functions of active galactic nuclei including Compton-thick populations

    SciTech Connect

    Ueda, Yoshihiro; Akiyama, Masayuki; Hasinger, Günther; Miyaji, Takamitsu; Watson, Michael G.

    2014-05-10

    We present the most up to date X-ray luminosity function (XLF) and absorption function of active galactic nuclei (AGNs) over the redshift range from 0 to 5, utilizing the largest, highly complete sample ever available obtained from surveys performed with Swift/BAT, MAXI, ASCA, XMM-Newton, Chandra, and ROSAT. The combined sample, including that of the Subaru/XMM-Newton Deep Survey, consists of 4039 detections in the soft (0.5-2 keV) and/or hard (>2 keV) band. We utilize a maximum likelihood method to reproduce the count rate versus redshift distribution for each survey, by taking into account the evolution of the absorbed fraction, the contribution from Compton-thick (CTK) AGNs, and broadband spectra of AGNs, including reflection components from tori based on the luminosity- and redshift-dependent unified scheme. We find that the shape of the XLF at z ∼ 1-3 is significantly different from that in the local universe, for which the luminosity-dependent density evolution model gives much better description than the luminosity and density evolution model. These results establish the standard population synthesis model of the X-ray background (XRB), which well reproduces the source counts, the observed fractions of CTK AGNs, and the spectrum of the hard XRB. The number ratio of CTK AGNs to the absorbed Compton-thin (CTN) AGNs is constrained to be ≈0.5-1.6 to produce the 20-50 keV XRB intensity within present uncertainties, by assuming that they follow the same evolution as CTN AGNs. The growth history of supermassive black holes is discussed based on the new AGN bolometric luminosity function.

  9. Review of two 1998 Mathematical Appendices Primary to Continuum Theory: Deflection Scattering and Redshift by a Particle-tied Aether

    NASA Astrophysics Data System (ADS)

    Osmaston, Miles F.

    My development of Continuum Theory rests importantly on two mathematical treatments and calculations which I wrote in 1994 and were published in 1998 as Appendices A and B to my PIRT V paper presented in London in 1996. In view of their continuing scientific relevance, this contribution to the V9 conference proceedings is a republication of those Appendices, subject to minimal re-editing. Appendix B, presented first, tackles our 1959 finding that the daylight sky brightness distribution at high altitude shows the presence of an additional contribution whose intensity and distribution which, on careful analysis, I identified as having come from a deflection scattering mechanism due to transmission by an (atmospheric) `particle-tied aether'. Appendix A shows that redshift is one of the consequences of such transmission. The parameters involved are then used to analyse the 1968 radio ground-wave caesium clock redshift observations of Sadeh et al and to extrapolate them to the intergalactic transmission paths pertinent to the cosmic redshift as a transmission effect, not a velocity. It finds this to be a reasonable evaluation within observational uncertainties, notably those of density and degree of ionization. In that case, there being no Big Bang, the temperature is precisely known from the CMBR, identified as synchrotron-type radiation from the randomly moving aether along the path, but slightly elevated where the path has traversed a heat-generating cluster.

  10. Hypocholesterolaemic Activity of Lupin Peptides: Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells

    PubMed Central

    Lammi, Carmen; Zanoni, Chiara; Ferruzza, Simonetta; Ranaldi, Giulia; Sambuy, Yula; Arnoldi, Anna

    2016-01-01

    Literature indicates that peptic and tryptic peptides derived from the enzymatic hydrolysis of lupin protein are able to modulate cholesterol metabolism in human hepatic HepG2 cells and that part of these peptides are absorbed in a small intestine model based on differentiated human Caco-2 cells. In this paper, a co-culture system, including Caco-2 and HepG2 cells, was investigated with two objectives: (a) to verify whether cholesterol metabolism in HepG2 cells was modified by the peptides absorption through Caco-2 cells; (b) to investigate how lupin peptides influence cholesterol metabolism in Caco-2 cells. The experiments showed that the absorbed peptides, not only maintained their bioactivity on HepG2 cells, but that this activity was improved by the crosstalk of the two cells systems in co-culture. In addition, lupin peptides showed a positive influence on cholesterol metabolism in Caco-2 cells, decreasing the proprotein convertase subtilisin/kexin type 9 (PCSK9) secretion. PMID:27455315

  11. Include Passive Solar in Your Renovations.

    ERIC Educational Resources Information Center

    Bender, Gerald F.; Probasco, Jack F.

    1981-01-01

    A checklist covers potential energy saving modifications in a building scheduled for renovation, and includes suggestions for room utilization, landscaping, and building envelope, solar control, and active system modifications. (Author)

  12. SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.

    PubMed

    Chen, Linyi; Maures, Travis J; Jin, Hui; Huo, Jeffrey S; Rabbani, Shafaat A; Schwartz, Jessica; Carter-Su, Christin

    2008-02-01

    Previous work showed that the adapter protein SH2B adapter protein 1beta (SH2B1) (SH2-B) binds to the activated form of the nerve growth factor (NGF) receptor TrkA and is critical for both NGF-dependent neurite outgrowth and maintenance. To identify SH2B1beta-regulated genes critical for neurite outgrowth, we performed microarray analysis of control PC12 cells and PC12 cells stably overexpressing SH2B1beta (PC12-SH2B1beta) or the dominant-negative SH2B1beta(R555E) [PC12-SH2B1beta(R555E)]. NGF-induced microarray expression of Plaur and Mmp10 genes was greatly enhanced in PC12-SH2B1beta cells, whereas NGF-induced Plaur and Mmp3 expression was substantially depressed in PC12-SH2B1beta(R555E) cells. Plaur, Mmp3, and Mmp10 are among the 12 genes most highly up-regulated after 6 h of NGF. Their protein products [urokinase plasminogen activator receptor (uPAR), matrix metalloproteinase 3 (MMP3), and MMP10] lie in the same pathway of extracellular matrix degradation; uPAR has been shown previously to be critical for NGF-induced neurite outgrowth. Quantitative real-time PCR analysis revealed SH2B1beta enhancement of NGF induction of all three genes and the suppression of NGF induction of all three when endogenous SH2B1 was reduced using short hairpin RNA against SH2B1 and in PC12-SH2B1beta(R555E) cells. NGF-induced levels of uPAR and MMP3/10 and neurite outgrowth through Matrigel (MMP3-dependent) were also increased in PC12-SH2B1beta cells. These results suggest that SH2B1beta stimulates NGF-induced neuronal differentiation at least in part by enhancing expression of a specific subset of NGF-sensitive genes, including Plaur, Mmp3, and/or Mmp10, required for neurite outgrowth.

  13. TaHsfA6f is a transcriptional activator that regulates a suite of heat stress protection genes in wheat (Triticum aestivum L.) including previously unknown Hsf targets.

    PubMed

    Xue, Gang-Ping; Drenth, Janneke; McIntyre, C Lynne

    2015-02-01

    Heat stress is a significant environmental factor adversely affecting crop yield. Crop adaptation to high-temperature environments requires transcriptional reprogramming of a suite of genes involved in heat stress protection. This study investigated the role of TaHsfA6f, a member of the A6 subclass of heat shock transcription factors, in the regulation of heat stress protection genes in Triticum aestivum (bread wheat), a poorly understood phenomenon in this crop species. Expression analysis showed that TaHsfA6f was expressed constitutively in green organs but was markedly up-regulated during heat stress. Overexpression of TaHsfA6f in transgenic wheat using a drought-inducible promoter resulted in up-regulation of heat shock proteins (HSPs) and a number of other heat stress protection genes that included some previously unknown Hsf target genes such as Golgi anti-apoptotic protein (GAAP) and the large isoform of Rubisco activase. Transgenic wheat plants overexpressing TaHsfA6f showed improved thermotolerance. Transactivation assays showed that TaHsfA6f activated the expression of reporter genes driven by the promoters of several HSP genes (TaHSP16.8, TaHSP17, TaHSP17.3, and TaHSP90.1-A1) as well as TaGAAP and TaRof1 (a co-chaperone) under non-stress conditions. DNA binding analysis revealed the presence of high-affinity TaHsfA6f-binding heat shock element-like motifs in the promoters of these six genes. Promoter truncation and mutagenesis analyses identified TaHsfA6f-binding elements that were responsible for transactivation of TaHSP90.1-A1 and TaGAAP by TaHsfA6f. These data suggest that TaHsfA6f is a transcriptional activator that directly regulates TaHSP, TaGAAP, and TaRof1 genes in wheat and its gene regulatory network has a positive impact on thermotolerance.

  14. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    SciTech Connect

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  15. The Melbourne Code Appendices: announcing a new approach for tracking nomenclatural decisions and a analysis of the history of nomenclatural proposals

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A newly expanded digital resource exists for tracking decisions on all nomenclature proposals potentially contributing to Appendices II-VIII of the International Code of Nomenclature for algae, fungi, and plants. This resource originated with the Smithsonian Institution's Proposals and Disposals web...

  16. Should Student Employment Be Subsidized? Conditional Counterfactuals and the Outcomes of Work-Study Participation: Appendices A and B. A CAPSEE Working Paper

    ERIC Educational Resources Information Center

    Scott-Clayton, Judith; Minaya, Veronica

    2014-01-01

    Student employment subsidies are one of the largest types of federal employment subsidies, and one of the oldest forms of student aid. Yet it is unclear whether they help or harm students' long term outcomes. This document contains the appendices to the report "Should Student Employment Be Subsidized? Conditional Counterfactuals and the…

  17. Irradiation effects on fracture toughness of two high-copper submerged-arc welds, HSSI series 5. Volume 2, Appendices E and F

    SciTech Connect

    Nanstad, R.K.; Haggag, F.M.; McCabe, D.E.; Iskander, S.K.; Bowman, K.O.; Menke, B.H.

    1992-10-01

    The Fifth Irradiation Series in the Heavy-Section Steel irradiation (HSSI) Program was aimed at obtaining a statistically significant fracture toughness data base on two weldments with high-copper contents to determine the shift and shape of the K{sub lc} curve as a consequence of irradiation. The program included irradiated Charpy V-notch impact, tensile, and drop-weight specimens in addition to compact fracture toughness specimens. Compact specimens with thicknesses of 25.4, 50.8, and 101.6 mm [1T C(T), 2T C(T), and 4T C(T), respectively] were irradiated. Additionally, unirradiated 6T C(T) and 8T C(T) specimens with the same K{sub lc} measuring capacity as the irradiated specimens were tested. The materials for this irradiation series were two weldments fabricated from special heats of weld wire with copper added to the melt. One lot of Linde 0124 flux was used for all the welds. Copper levels for the two welds are 0.23 and 0.31 wt %, while the nickel contents for both welds are 0.60 wt %. Twelve capsules of specimens were irradiated in the pool-side facility of the Oak Ridge Research Reactor at a nominal temperature of 288{degree}C and an average fluence of about 1.5 {times} 10{sup 19} neutrons/cm{sup 2} (> 1 MeV). This volume, Appendices E and F, contains the load-displacement curves and photographs of the fracture toughness specimens from the 72W weld (0.23 wt % Cu) and the 73 W weld (0.31 wt % Cu), respectively.

  18. User manual for AQUASTOR: a computer model for cost analysis of aquifer thermal-energy storage oupled with district-heating or cooling systems. Volume II. Appendices

    SciTech Connect

    Huber, H.D.; Brown, D.R.; Reilly, R.W.

    1982-04-01

    A computer model called AQUASTOR was developed for calculating the cost of district heating (cooling) using thermal energy supplied by an aquifer thermal energy storage (ATES) system. the AQUASTOR Model can simulate ATES district heating systems using stored hot water or ATES district cooling systems using stored chilled water. AQUASTOR simulates the complete ATES district heating (cooling) system, which consists of two prinicpal parts: the ATES supply system and the district heating (cooling) distribution system. The supply system submodel calculates the life-cycle cost of thermal energy supplied to the distribution system by simulating the technical design and cash flows for the exploration, development, and operation of the ATES supply system. The distribution system submodel calculates the life-cycle cost of heat (chill) delivered by the distribution system to the end-users by simulating the technical design and cash flows for the construction and operation of the distribution system. The model combines the technical characteristics of the supply system and the technical characteristics of the distribution system with financial and tax conditions for the entities operating the two systems into one techno-economic model. This provides the flexibility to individually or collectively evaluate the impact of different economic and technical parameters, assumptions, and uncertainties on the cost of providing district heating (cooling) with an ATES system. This volume contains all the appendices, including supply and distribution system cost equations and models, descriptions of predefined residential districts, key equations for the cooling degree-hour methodology, a listing of the sample case output, and appendix H, which contains the indices for supply input parameters, distribution input parameters, and AQUASTOR subroutines.

  19. Activities.

    ERIC Educational Resources Information Center

    Kincaid, Charlene; And Others

    1993-01-01

    Presents an activity in which students collect and organize data from a real-world simulation of the scientific concept of half life. Students collect data using a marble sifter, analyze the data using a graphing calculator, and determine an appropriate mathematical model. Includes reproducible worksheets. (MDH)

  20. Larvicidal activity of Blumea eriantha essential oil and its components against six mosquito species, including Zika virus vectors: the promising potential of (4E,6Z)-allo-ocimene, carvotanacetone and dodecyl acetate.

    PubMed

    Benelli, Giovanni; Govindarajan, Marimuthu; Rajeswary, Mohan; Senthilmurugan, Sengamalai; Vijayan, Periasamy; Alharbi, Naiyf S; Kadaikunnan, Shine; Khaled, Jamal M

    2017-04-01

    The effective and environmentally sustainable control of mosquitoes is a challenge of essential importance. This is due to the fact that some invasive mosquitoes, with special reference to the Aedes genus, are particularly difficult to control, due to their high ecological plasticity. Moreover, the indiscriminate overuse of synthetic insecticides resulted in undesirable effects on human health and non-target organisms, as well as resistance development in targeted vectors. Here, the leaf essential oil (EO) extracted from a scarcely studied plant of ethno-medicinal interest, Blumea eriantha (Asteraceae), was tested on the larvae of six mosquitoes, including Zika virus vectors. The B. eriantha EO was analyzed by GC and GC-MS. The B. eriantha EO showed high toxicity against 3rd instar larvae of six important mosquito species: Anopheles stephensi (LC50=41.61 μg/ml), Aedes aegypti (LC50=44.82 μg/ml), Culex quinquefasciatus (LC50 =48.92 μg/ml), Anopheles subpictus (LC50=51.21 μg/ml), Ae. albopictus (LC50=56.33 μg/ml) and Culex tritaeniorhynchus (LC50=61.33 μg/ml). The major components found in B. eriantha EO were (4E,6Z)-allo-ocimene (12.8%), carvotanacetone (10.6%), and dodecyl acetate (8.9%). Interestingly, two of the main EO components, (4E,6Z)-allo-ocimene and carvotanacetone, achieved LC50 lower than 10 μg/ml on all tested mosquito species. The acute toxicity of B. eriantha EO and its major constituents on four aquatic predators of mosquito larval instars was limited, with LC50 ranging from 519 to 11.431 μg/ml. Overall, the larvicidal activity of (4E,6Z)-allo-ocimene and carvotanacetone far exceed most of the LC50 calculated in current literature on mosquito botanical larvicides, allowing us to propose both of them as potentially alternatives for developing eco-friendly mosquito control tools.