Science.gov

Sample records for activities appendixes include

  1. Adult Education Literacy Instruction. Appendix: Tables of Studies Included in the Review

    ERIC Educational Resources Information Center

    National Institute for Literacy, 2010

    2010-01-01

    Included here are two appendixes to "Adult Education Literacy Instruction: A Review of the Research." Appendix A, "Adult Studies," contains: (1) Assessment Profiles; (2) Alphabetics; (3) Fluency; (4) Vocabulary; and (5) Comprehension. Appendix B, "Adolescent Studies," contains: (1) Alphabetics; (2) Fluency; (3) Vocabulary; and (4) Comprehension.…

  2. Operational Control Procedures for the Activated Sludge Process: Appendix.

    ERIC Educational Resources Information Center

    West, Alfred W.

    This document is the appendix for a series of documents developed by the National Training and Operational Technology Center describing operational control procedures for the activated sludge process used in wastewater treatment. Categories discussed include: control test data, trend charts, moving averages, semi-logarithmic plots, probability…

  3. 12 CFR Appendix A to Subpart D of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... or gain includes engaging in any of the activities in paragraph (b)(1) of this Appendix in the...

  4. 12 CFR Appendix A to Subpart D of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... or gain includes engaging in any of the activities in paragraph (b)(1) of this Appendix in the...

  5. 12 CFR Appendix A to Subpart D of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... or gain includes engaging in any of the activities in paragraph (b)(1) of this Appendix in the...

  6. 12 CFR Appendix A to Subpart D of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... or gain includes engaging in any of the activities in paragraph (b)(1) of this Appendix in the...

  7. 30 CFR 254.28 - What information must I include in the “In situ burning plan” appendix?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... burning planâ appendix? 254.28 Section 254.28 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF... include in the “In situ burning plan” appendix? Your in situ burning plan must be consistent with any... situ burning plan must include: (a) A description of the in situ burn equipment including...

  8. 49 CFR Appendix C- to Part 544... - Appendix C- to Part 544 Motor Vehicle Rental and Leasing Companies (Including Licensees and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...-Car Company acquired ownership of Vanguard Car Rental USA in August 2007. ... Leasing Companies (Including Licensees and Franchisees) Subject to the Reporting Requirements of Part 544 C Appendix C- to Part 544 Motor Vehicle Rental and Leasing Companies (Including Licensees...

  9. 49 CFR Appendix C to Part 544 - Motor Vehicle Rental and Leasing Companies (Including Licensees and Franchisees) Subject to the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (Including Licensees and Franchisees) Subject to the Reporting Requirements of Part 544 C Appendix C to Part... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INSURER REPORTING REQUIREMENTS Pt. 544, App. C Appendix C to Part 544—Motor Vehicle Rental and Leasing Companies (Including Licensees and...

  10. 34 CFR Appendix B to Subpart B of... - Appendix I, Standards for Audit of Governmental Organizations, Programs, Activities, and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Organizations, Programs, Activities, and Functions (GAO) B Appendix B to Subpart B of Part 668 Education... Programs Pt. 668, Subpt. B, App. B Appendix B to Subpart B of Part 668—Appendix I, Standards for Audit of... required for the practice of public accountancy by the regulatory authorities of the States.” 1 1 Letter...

  11. 34 CFR Appendix B to Subpart B of... - Appendix I, Standards for Audit of Governmental Organizations, Programs, Activities, and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Organizations, Programs, Activities, and Functions (GAO) B Appendix B to Subpart B of Part 668 Education... Programs Pt. 668, Subpt. B, App. B Appendix B to Subpart B of Part 668—Appendix I, Standards for Audit of... required for the practice of public accountancy by the regulatory authorities of the States.” 1 1 Letter...

  12. 34 CFR Appendix B to Subpart B of... - Appendix I, Standards for Audit of Governmental Organizations, Programs, Activities, and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Organizations, Programs, Activities, and Functions (GAO) B Appendix B to Subpart B of Part 668 Education... Programs Pt. 668, Subpt. B, App. B Appendix B to Subpart B of Part 668—Appendix I, Standards for Audit of... required for the practice of public accountancy by the regulatory authorities of the States.” 1 1 Letter...

  13. 34 CFR Appendix B to Subpart B of... - Appendix I, Standards for Audit of Governmental Organizations, Programs, Activities, and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false Appendix I, Standards for Audit of Governmental Organizations, Programs, Activities, and Functions (GAO) B Appendix B to Subpart B of Part 668 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT...

  14. 40 CFR Appendix A to Part 419 - Processes Included in the Determination of BAT Effluent Limitations for Total Chromium...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true Processes Included in the Determination of BAT Effluent Limitations for Total Chromium, Hexavalent Chromium, and Phenolic Compounds (4AAP) A Appendix A to Part 419 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)...

  15. RBDMS user`s guide which includes the RBDMS administrative guide, Version 4.0. Appendix A

    SciTech Connect

    1995-03-01

    RBDMS (Risk Based Data Management System) is an oil and gas electronic data management system which stems from the idea developed from four previous projects conducted by the American Petroleum Institute (API) and the Ground Water Protection Council (GWPC). The first study studied oil and gas industry injection well corrosion. It included a methodology for assessing the probability of contaminating underground sources of drinking water (USDWs) via Class 2 injection well operations. A feasibility study was conducted to investigate if an electronic data management system could incorporate the methodology. A second feasibility study was conducted to test the methodology on a much small basis. The RBDMS effort then continued through a grant from DOE with a multi-task project consisting of an inventory and needs assessment of 25 oil and gas producing states pertaining to oil and gas production/regulatory activities, state geological/hydrogeological considerations, Class 2 underground injection activities, electronic data management needs and functional requirements, environmental risk assessment and management objectives, resultant benefit of a RBDMS, and various information and data required for the design and development of a RBDMS in individual states. This appendix contains the documentation for the use of the RBDMS.

  16. 32 CFR Appendix D to Part 37 - What Common National Policy Requirements May Apply and Need To Be Included in TIAs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... under the heading “Nondiscrimination” in Appendix B to 32 CFR part 22. 2. If the research involves human... rule about lobbying prohibitions, which is implemented by the DoD at 32 CFR part 28. The prohibitions apply to all financial assistance. Appendix A to 32 CFR part 22 includes a sample provision that you...

  17. 32 CFR Appendix D to Part 37 - What Common National Policy Requirements May Apply and Need To Be Included in TIAs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... rule about lobbying prohibitions, which is implemented by the DoD at 32 CFR part 28. The prohibitions apply to all financial assistance. Appendix A to 32 CFR part 22 includes a sample provision that you may... conditions, or assurances. Appendix B to 32 CFR part 22 lists national policy requirements that...

  18. 32 CFR Appendix D to Part 37 - What Common National Policy Requirements May Apply and Need To Be Included in TIAs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... rule about lobbying prohibitions, which is implemented by the DoD at 32 CFR part 28. The prohibitions apply to all financial assistance. Appendix A to 32 CFR part 22 includes a sample provision that you may... conditions, or assurances. Appendix B to 32 CFR part 22 lists national policy requirements that...

  19. Appendix.

    ERIC Educational Resources Information Center

    NatureScope, 1989

    1989-01-01

    Includes a glossary, bibliography, reference books, children's books, cassettes, films, filmstrips, records, slides, videos, booklets, periodicals, posters, other activity sources, information sources, index, and areas of tropical rain forests. (Author/RT)

  20. Appendix.

    ERIC Educational Resources Information Center

    Naturescope, 1987

    1987-01-01

    Contains a glossary of terms related to endangered species and lists reference books, children's books, audio-visual materials, software, and activity sources on the topics. Also identifies wildlife laws and explains what they mean. An index of issues of "Ranger Rick," which includes articles on endangered species, is included. (ML)

  1. 49 CFR Appendix A to Part 21 - Activities to Which This Part Applies

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Activities to Which This Part Applies A Appendix A... 1964 Pt. 21, App. A Appendix A to Part 21—Activities to Which This Part Applies 1. Use of grants made.... 141(a)). 6. Use of Coast Guard personnel for duty in connection with maritime instruction and...

  2. 14 CFR Appendix C to Part 1215 - Typical User Activity Timeline

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Typical User Activity Timeline C Appendix C to Part 1215 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION TRACKING AND DATA RELAY SATELLITE SYSTEM (TDRSS) Pt. 1215, App. C Appendix C to Part 1215—Typical User Activity...

  3. 32 CFR Appendix C to Part 552 - Authorized Activities for Fort Lewis Maneuver Area Access

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Authorized Activities for Fort Lewis Maneuver Area Access C Appendix C to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF.... 552, App. C Appendix C to Part 552—Authorized Activities for Fort Lewis Maneuver Area Access...

  4. 12 CFR Appendix I to Part 27 - Monthly Home Loan Activity Format

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Monthly Home Loan Activity Format I Appendix I to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM Pt. 27, App. I Appendix I to Part 27—Monthly Home Loan Activity Format...

  5. 12 CFR Appendix I to Part 27 - Monthly Home Loan Activity Format

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Monthly Home Loan Activity Format I Appendix I to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM Pt. 27, App. I Appendix I to Part 27—Monthly Home Loan Activity Format...

  6. 32 CFR Appendix D to Part 552 - Unauthorized Activities in Fort Lewis Maneuver Areas

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Areas D Appendix D to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Pt. 552, App. D Appendix D to Part 552—Unauthorized Activities in Fort Lewis Maneuver Areas Civilian...

  7. 32 CFR Appendix D to Part 552 - Unauthorized Activities in Fort Lewis Maneuver Areas

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Areas D Appendix D to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Pt. 552, App. D Appendix D to Part 552—Unauthorized Activities in Fort Lewis Maneuver Areas Civilian...

  8. 12 CFR Appendix A to Subpart B of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  9. 12 CFR Appendix A to Part 610 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  10. 12 CFR Appendix A to Subpart I of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... online application or other automated system on behalf of the consumer; or (iv) Is not engaged in... activities in paragraph (b)(1) of this appendix in the course of carrying out employment duties, even if...

  11. 12 CFR Appendix A to Subpart B of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  12. 12 CFR Appendix A to Part 610 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  13. 12 CFR Appendix A to Subpart I of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... online application or other automated system on behalf of the consumer; or (iv) Is not engaged in... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  14. 12 CFR Appendix A to Subpart I of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... online application or other automated system on behalf of the consumer; or (iv) Is not engaged in... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  15. 12 CFR Appendix A to Subpart I of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... online application or other automated system on behalf of the consumer; or (iv) Is not engaged in... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  16. 12 CFR Appendix A to Subpart B of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  17. 12 CFR Appendix A to Subpart B of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  18. 6 CFR Appendix A to Part 21 - Activities to Which This Part Applies

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...—Activities to Which This Part Applies Note: Failure to list a type of Federal assistance in appendix A shall... Fund. 8. U.S. Coast Guard Bridge Alteration. 9. Use of Customs personnel and facilities by any...

  19. Appendix.

    ERIC Educational Resources Information Center

    Naturescope, 1986

    1986-01-01

    Presents: (1) a list of 23 questions about mammals (with answers); (2) a glossary with mammal-related words; and (3) a bibliography listing reference books, children's books, audiovisual aids, field guides, activity sources, and mammal-related articles appearing in "Ranger Rick" magazine. (ML)

  20. 32 CFR Appendix D to Part 37 - What Common National Policy Requirements May Apply and Need To Be Included in TIAs?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... concerning drug-free workplace in the Governmentwide common rule that the DoD has codified at 32 CFR part 26... rule about lobbying prohibitions, which is implemented by the DoD at 32 CFR part 28. The prohibitions apply to all financial assistance. Appendix A to 32 CFR part 22 includes a sample provision that you...

  1. 32 CFR Appendix D to Part 37 - What Common National Policy Requirements May Apply and Need To Be Included in TIAs?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... concerning drug-free workplace in the Governmentwide common rule that the DoD has codified at 32 CFR part 26... rule about lobbying prohibitions, which is implemented by the DoD at 32 CFR part 28. The prohibitions apply to all financial assistance. Appendix A to 32 CFR part 22 includes a sample provision that you...

  2. 32 CFR Appendix B to Part 80 - Procedures for Special Educational Programs (Including Related Services) for Preschool Children...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Procedures for Special Educational Programs... Appendix B to Part 80 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL..., not merely to provide a single general intelligence quotient. 3. The evaluation shall be conducted...

  3. 14 CFR Appendix C to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., 14 CFR Ch. III (the “Regulations”). This agreement applies to . In consideration of the mutual... Assumption of Responsibility for Permitted Activities C Appendix C to Part 440 Aeronautics and Space... FINANCIAL RESPONSIBILITY Pt. 440, App. C Appendix C to Part 440—Agreement for Waiver of Claims...

  4. 14 CFR Appendix B to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities B Appendix B to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. B Appendix...

  5. 14 CFR Appendix C to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities C Appendix C to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. C Appendix...

  6. 14 CFR Appendix C to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities C Appendix C to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. C Appendix...

  7. 14 CFR Appendix C to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Permitted Activities C Appendix C to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. C Appendix...

  8. 14 CFR Appendix B to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities B Appendix B to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. B Appendix...

  9. 14 CFR Appendix B to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities B Appendix B to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. B Appendix...

  10. 14 CFR Appendix B to Part 440 - Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Agreement for Waiver of Claims and Assumption of Responsibility for Licensed Activities B Appendix B to Part 440 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING FINANCIAL RESPONSIBILITY Pt. 440, App. B Appendix...

  11. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  12. 32 CFR Appendix D to Part 169a - Commercial Activities Management Information System (CAMIS)

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Commercial Activities Management Information System (CAMIS) D Appendix D to Part 169a National Defense Department of Defense OFFICE OF THE SECRETARY...—Department of the Air Force G—National Security Agency/Central Security Service H—Defense Nuclear Agency...

  13. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., materials, support vessels, and strategies listed are suitable, within the limits of current technology, for... equipment. Examples of acceptable terms include those defined in American Society for Testing of...

  14. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., materials, support vessels, and strategies listed are suitable, within the limits of current technology, for... equipment. Examples of acceptable terms include those defined in American Society for Testing of...

  15. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., materials, support vessels, and strategies listed are suitable, within the limits of current technology, for... equipment. Examples of acceptable terms include those defined in American Society for Testing of...

  16. 30 CFR 254.29 - What information must I include in the “Training and drills” appendix?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.29 What...) Identify and include the dates of the training provided to members of the spill-response management...

  17. 30 CFR 254.28 - What information must I include in the “In situ burning plan” appendix?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities... burning procedures, including provisions for ignition of an oil spill; (c) A discussion of...

  18. 30 CFR 254.24 - What information must I include in the “Equipment inventory” appendix?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities... inventory appendix” must include: (a) An inventory of spill-response materials and supplies,...

  19. 30 CFR 254.29 - What information must I include in the “Training and drills” appendix?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.29 What information...) Identify and include the dates of the training provided to members of the spill-response management...

  20. 30 CFR 254.29 - What information must I include in the “Training and drills” appendix?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.29 What...) Identify and include the dates of the training provided to members of the spill-response management...

  1. 30 CFR 254.24 - What information must I include in the “Equipment inventory” appendix?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.24 What... include: (a) An inventory of spill-response materials and supplies, services, equipment, and...

  2. 30 CFR 254.28 - What information must I include in the “In situ burning plan” appendix?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.28 What..., including provisions for ignition of an oil spill; (c) A discussion of environmental effects of an in...

  3. 30 CFR 254.24 - What information must I include in the “Equipment inventory” appendix?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.24 What... include: (a) An inventory of spill-response materials and supplies, services, equipment, and...

  4. 30 CFR 254.28 - What information must I include in the “In situ burning plan” appendix?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.28 What..., including provisions for ignition of an oil spill; (c) A discussion of environmental effects of an in...

  5. 30 CFR 254.28 - What information must I include in the “In situ burning plan” appendix?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.28 What..., including provisions for ignition of an oil spill; (c) A discussion of environmental effects of an in...

  6. 30 CFR 254.24 - What information must I include in the “Equipment inventory” appendix?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.24 What... include: (a) An inventory of spill-response materials and supplies, services, equipment, and...

  7. 30 CFR 254.29 - What information must I include in the “Training and drills” appendix?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.29 What...) Identify and include the dates of the training provided to members of the spill-response management...

  8. Study Modules for Calculus-Based General Physics. [Includes Modules 41 and 42: Lenses and Mirrors; Relativity; and Appendix].

    ERIC Educational Resources Information Center

    Fuller, Robert G., Ed.; And Others

    This is part of a series of 42 Calculus Based Physics (CBP) modules totaling about 1,000 pages. The modules include study guides, practice tests, and mastery tests for a full-year individualized course in calculus-based physics based on the Personalized System of Instruction (PSI). The units are not intended to be used without outside materials;…

  9. 32 CFR Appendix B to Part 80 - Procedures for Special Educational Programs (Including Related Services) for Preschool Children...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... determined individually, based upon the preschool child's or child's performance, behavior, and needs when... (Including Related Services) for Preschool Children and Children With Disabilities (3-21 years Inclusive) B... DISABILITIES AND THEIR FAMILIES, AND SPECIAL EDUCATION CHILDREN WITH DISABILITIES WITHIN THE SECTION 6...

  10. 30 CFR 254.26 - What information must I include in the “Worst case discharge scenario” appendix?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... potentially could affect. The trajectory analysis chosen must reflect the maximum distance from the facility..., materials, support vessels, and strategies listed are suitable, within the limits of current technology, for... equipment. Examples of acceptable terms include those defined in American Society for Testing of...

  11. A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix.

    PubMed

    Hara, Kieko; Saito, Tsuyoshi; Hayashi, Takuo; Yimit, Alkam; Takahashi, Michiko; Mitani, Keiko; Takahashi, Makoto; Yao, Takashi

    2015-09-01

    Appendiceal mucinous tumors (AMTs) are classified as low-grade appendiceal mucinous neoplasms (LAMNs) or mucinous adenocarcinomas (MACs), although their carcinogenesis is not well understood. As somatic activating mutations of GNAS are considered to be characteristic of LAMNs while TP53 mutations have been shown to be specific to MACs, MACs are unlikely to result from transformation of LAMNs. However, emerging evidence also shows the presence of GNAS mutations in MACs. We examined 16 AMTs (11 LAMNs and 5 MACs) for genetic alterations of GNAS, KRAS, BRAF, TP53, CTNNB1, and TERT promoter in order to elucidate the possibility of a shared genetic background in the two tumor types. Extensive histological examination revealed the presence of a low-grade component in all cases of MAC. GNAS mutations were detected in two LAMNs and in one MAC, although the GNAS mutation in this MAC was a nonsense mutation (Q227X) expected not to be activating mutation. TP53 mutations were detected in three LAMNs; they were frequently detected in MACs. KRAS mutations were detected in three LAMNs and three MACs, and CTNNB1 mutations were detected in two LAMNs. KRAS mutation and activating mutation of GNAS occurred exclusively in AMTs. BRAF and TERT mutations were not detected. Overexpression of p53 was observed in only two MACs, and p53 immunostaining clearly discriminated the high-grade lesion from a low-grade component in one. These findings suggest that p53 overexpression plays an important role in the carcinogenesis of AMTs and that, in addition to mutations of GNAS, KRAS and TP53 alterations might be shared by AMTs, thus providing evidence for the possible progression of LAMNs to MAC.

  12. Antiradical activity of gallic acid included in lipid interphases.

    PubMed

    Salcedo, C L; Frías, M A; Cutro, A C; Nazareno, M A; Disalvo, E A

    2014-10-01

    Polyphenols are well known as antioxidant agents and by their effects on the hydration layers of lipid interphases. Among them, gallic acid and its derivatives are able to decrease the dipole potential and to act in water as a strong antioxidant. In this work we have studied both effects on lipid interphases in monolayers and bilayers of dimyristoylphosphatidylcholine. The results show that gallic acid (GA) increases the negative surface charges of large unilamellar vesicles (LUVs) and decreases the dipole potential of the lipid interphase. As a result, positively charged radical species such as ABTS(+) are able to penetrate the membrane forming an association with GA. These results allow discussing the antiradical activity (ARA) of GA at the membrane phase which may be taking place in water spaces between the lipids.

  13. Hematochezia due to Angiodysplasia of the Appendix

    PubMed Central

    Choi, Je-Min; Lee, Seung-Hyun; Ahn, Byung-Kwon; Baek, Sung-Uhn

    2016-01-01

    Common causes of lower gastrointestinal bleeding include diverticular disease, vascular disease, inflammatory bowel disease, neoplasms, and hemorrhoids. Lower gastrointestinal bleeding of appendiceal origin is extremely rare. We report a case of lower gastrointestinal bleeding due to angiodysplasia of the appendix. A 72-year-old man presented with hematochezia. Colonoscopy showed active bleeding from the orifice of the appendix. We performed a laparoscopic appendectomy. Microscopically, dilated veins were found at the submucosal layer of the appendix. The patient was discharged uneventfully. Although lower gastrointestinal bleeding of appendiceal origin is very rare, clinicians should consider it during differential diagnosis. PMID:27437394

  14. 34 CFR Appendix A to Subpart B of... - Standards for Audit of Governmental Organizations, Programs, Activities, and Functions (GAO)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Programs, Activities, and Functions (GAO) A Appendix A to Subpart B of Part 668 Education Regulations of... Organizations, Programs, Activities, and Functions (GAO) Part III Chapter 3—Independence (a) The Third general... objectives of a particular program. 3. Previous involvement in a decisionmaking or management capacity in...

  15. 12 CFR Appendix to Part 1253 - Prior Approval for Enterprise Products-Instructions and Notice of New Activity Form

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...

  16. 12 CFR Appendix to Part 1253 - Prior Approval for Enterprise Products-Instructions and Notice of New Activity Form

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...

  17. 12 CFR Appendix to Part 1253 - Prior Approval for Enterprise Products-Instructions and Notice of New Activity Form

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...

  18. 12 CFR Appendix to Part 1253 - Prior Approval for Enterprise Products-Instructions and Notice of New Activity Form

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Noticeof New Activity Form ER02JY09.000...

  19. 12 CFR Appendix to Part 1253 - Prior Approval for Enterprise Products-Instructions and Notice of New Activity Form

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...

  20. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Transportation Facility Maintenance Program A Appendix A to Subpart G Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance Pt. 170... Transportation Facility Maintenance Program The following activities are eligible for BIA Transportation...

  1. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Transportation Facility Maintenance Program A Appendix A to Subpart G Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance Pt. 170... Transportation Facility Maintenance Program The following activities are eligible for BIA Transportation...

  2. 25 CFR Appendix A to Subpart G - List of Activities Eligible for Funding Under BIA Transportation Facility Maintenance Program

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Transportation Facility Maintenance Program A Appendix A to Subpart G Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance Pt. 170... Transportation Facility Maintenance Program The following activities are eligible for BIA Transportation...

  3. Optimal design of active and semi-active suspensions including time delays and preview

    NASA Astrophysics Data System (ADS)

    Hac', A.; Youn, I.

    1993-10-01

    Several control laws for active and semi-active suspension based on a linear half car model are derived and investigated. The strategies proposed take full advantage of the fact that the road input to the rear wheels is a delayed version of that to the front wheels, which in turn can be obtained either from the measurements of the front wheels and body motions or by direct preview of road irregularities if preview sensors are available. The suspension systems are optimized with respect to ride comfort, road holding and suspension rattle space as expressed by the mean-square-values of body acceleration (including effects of heave and pitch), tire deflections and front and rear suspension travels. The optimal control laws that minimize the given performance index and include passivity constraints in the semi-active case are derived using calculus of variation. The optimal semi-active suspension becomes piecewise linear, varying between passive and fully active systems and combinations of them. The performances of active and semi-active systems with and without preview were evaluated by numerical simulation in the time and frequency domains. The results show that incorporation of time delay between the front and rear axles in controller design improves the dynamic behavior of the rear axle and control of body pitch motion, while additional preview improves front wheel dynamics and body heave.

  4. 32 CFR Appendix E to Part 37 - What Provisions May a Participant Need To Include When Purchasing Goods or Services Under a TIA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and..., which are for substantive research program performance. B. Appendix A to 32 CFR part 34 lists seven... funds that takes place in connection with obtaining any Federal award. For further details, see 32...

  5. 32 CFR Appendix E to Part 37 - What Provisions May a Participant Need To Include When Purchasing Goods or Services Under a TIA?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and..., which are for substantive research program performance. B. Appendix A to 32 CFR part 34 lists seven... funds that takes place in connection with obtaining any Federal award. For further details, see 32...

  6. Study concerning the utilization of the ocean spreading center environment for the conversion of biomass to a liquid fuel. (Includes Appendix A: hydrothermal petroleum genesis). [Supercritical water

    SciTech Connect

    Steverson, M.; Stormberg, G.

    1985-01-01

    This document contains a report on the feasibility of utilizing energy obtained from ocean spreading centers as process heat for the conversion of municipal solid wastes to liquid fuels. The appendix contains a paper describing hydrothermal petroleum genesis. Both have been indexed separately for inclusion in the Energy Data Base. (DMC)

  7. 32 CFR Appendix E to Part 37 - What Provisions May a Participant Need To Include When Purchasing Goods or Services Under a TIA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and..., which are for substantive research program performance. B. Appendix A to 32 CFR part 34 lists seven... funds that takes place in connection with obtaining any Federal award. For further details, see 32...

  8. 32 CFR Appendix E to Part 37 - What Provisions May a Participant Need To Include When Purchasing Goods or Services Under a TIA?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and..., which are for substantive research program performance. B. Appendix A to 32 CFR part 34 lists seven... funds that takes place in connection with obtaining any Federal award. For further details, see 32...

  9. 32 CFR Appendix C to Part 552 - Authorized Activities for Fort Lewis Maneuver Area Access

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Pt... route only (appendix B) Non-Commercial recreational use: Hunting, fishing and trapping (FL Reg...

  10. 12 CFR Appendix A to Part 761 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... responsible for further verification of information; (iii) Is inputting information into an online application... in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  11. 12 CFR Appendix A to Subpart F of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... (b)(1) of this Appendix in the course of carrying out employment duties, even if the employee...

  12. 12 CFR Appendix A to Part 761 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... responsible for further verification of information; (iii) Is inputting information into an online application... in paragraph (b)(1) of this Appendix in the course of carrying out employment duties, even if...

  13. 12 CFR Appendix A to Subpart F of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... (b)(1) of this Appendix in the course of carrying out employment duties, even if the employee...

  14. 12 CFR Appendix A to Part 1007 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... in paragraph (b)(1) of this appendix in the course of carrying out employment duties, even if...

  15. 12 CFR Appendix A to Part 1007 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... in paragraph (b)(1) of this appendix in the course of carrying out employment duties, even if...

  16. 12 CFR Appendix A to Part 1007 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... in paragraph (b)(1) of this appendix in the course of carrying out employment duties, even if...

  17. 12 CFR Appendix A to Subpart F of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... (b)(1) of this Appendix in the course of carrying out employment duties, even if the employee...

  18. 12 CFR Appendix A to Subpart F of... - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...; (iii) Is inputting information into an online application or other automated system on behalf of the... (b)(1) of this appendix in the course of carrying out employment duties, even if the employee...

  19. Improvements to the FATOLA computer program including added actively controlled landing gear subroutines

    NASA Technical Reports Server (NTRS)

    Mall, G. H.

    1983-01-01

    Modifications to a multi-degree-of-freedom flexible aircraft take-off and landing analysis (FATOLA) computer program, including a provision for actively controlled landing gears to expand the programs simulation capabilities, are presented. Supplemental instructions for preparation of data and for use of the modified program are included.

  20. 7 CFR 3402.16 - Appendix.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Appendix. 3402.16 Section 3402.16 Agriculture... Application § 3402.16 Appendix. Any additional supporting information deemed essential to enhancing the application should be included in an Appendix and referenced in the national need narrative....

  1. Appendix A; Appendix B

    SciTech Connect

    Dragan C. Curcija

    2006-09-15

    This is the summary page for the technical and other reports on the DOE Cooperative Agreement DE-FC36-94CH10604 for the period of January 1, 2000 to December 31, 2004. The progress, technical and other reports and publications are consolidated by the contracting year and also by the cooperative agreement tasks. The listing sorted by tasks is also sub-sorted by fiscal year for easier navigation. These listings are given in appendix A and Appendix B of this summary report. Individual report files are located in each fiscal year directory (i.e., FY00, FY01, etc. up to FY04). The complete listing and report files are also posted on the web site and is fully navigable by these two criteria. The web site is at: http://www.ceere.org/beep/beep{_}pubsanddownloads.html. More significant and less obvious part of deliverables are applications of this research, which are used in everyday operations of NFRC, software tools and manufacturers design practice, which has significantly changed as a result of this and related research efforts.

  2. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities, and Bibliography. Revised.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.; Long, Alison T.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population matters. The document describes 15 class sessions which integrate information for sociology, anthropology, psychology, biology, animal behavior, and education. Topics include the history of human…

  3. 76 FR 10385 - Agency Information Collection Activities: Various Contract Related Forms That Will be Included in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... SECURITY Agency Information Collection Activities: Various Contract Related Forms That Will be Included in the Homeland Security Acquisition Regulation, DHS FORM 0700-01, DHS FORM 0700-02, DHS FORM 0700-03...: The Department of Homeland Security, Office of Chief Procurement Officer, Acquisition Policy...

  4. 14 CFR Appendix D to Part 43 - Scope and Detail of Items (as Applicable to the Particular Aircraft) To Be Included in Annual and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Internal engine—for cylinder compression and for metal particles or foreign matter on screens and sump...—for improper installation and poor condition. (4) Antenna including trailing antenna—for...

  5. 14 CFR Appendix C to Part 151 - Appendix C to Part 151

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Appendix C to Part 151 C Appendix C to Part...) AIRPORTS FEDERAL AID TO AIRPORTS Pt. 151, App. C Appendix C to Part 151 There is set forth below an... Items 1. Maintenance-type work, including: (a) Seal coats. (b) Crack filling. (c) Resealing joints....

  6. Image Display and Manipulation System (IDAMS) program documentation, Appendixes A-D. [including routines, convolution filtering, image expansion, and fast Fourier transformation

    NASA Technical Reports Server (NTRS)

    Cecil, R. W.; White, R. A.; Szczur, M. R.

    1972-01-01

    The IDAMS Processor is a package of task routines and support software that performs convolution filtering, image expansion, fast Fourier transformation, and other operations on a digital image tape. A unique task control card for that program, together with any necessary parameter cards, selects each processing technique to be applied to the input image. A variable number of tasks can be selected for execution by including the proper task and parameter cards in the input deck. An executive maintains control of the run; it initiates execution of each task in turn and handles any necessary error processing.

  7. Active seat suspension for a small vehicle: considerations for control system including observer

    NASA Astrophysics Data System (ADS)

    Katsumata, Hiroyuki; Shiino, Hiroshi; Oshinoya, Yasuo; Ishibashi, Kazuhisa; Ozaki, Koichi; Ogino, Hirohiko

    2007-12-01

    We have examined the improvement of ride quality and the reduction of riding fatigue brought about by the active control of the seat suspension of small vehicles such as one-seater electric automobiles. A small active seat suspension, which is easy to install, was designed and manufactured for one-seater electric automobiles. For the actuator, a maintenance-free voice coil motor used as a direct drive was adopted. For fundamental considerations, we designed a one-degree-of-freedom model for the active seat suspension system. Then, we designed a disturbance cancellation control system that includes the observer for a two-degree-of-freedom model. In an actual driving test, a test road, in which the concavity and convexity of an actual road surface were simulated using hard rubber, was prepared and the control performance of vertical vibrations of the seat surface during driving was examined. As a result, in comparison with the one-degree-of-freedom control system, it was confirmed that the control performance was improved by the two-degree-of-freedom control system that includes the observer.

  8. Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage.

    PubMed

    Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Kjaer, Karina Hansen; Justesen, Just; Kelve, Merike

    2014-02-01

    2',5'-Oligoadenylate synthetases (OASs) belong to the nucleotidyl transferase family together with poly(A) polymerases, CCA-adding enzymes and the recently discovered cyclic-GMP-AMP synthase (cGAS). Mammalian OASs have been thoroughly characterized as components of the interferon-induced antiviral system. The OAS activity and the respective genes were also discovered in marine sponges where the interferon system is absent. In this study the recombinant OASs from several multicellular animals and their closest unicellular relative, a choanoflagellate, were expressed in a bacterial expression system and their enzymatic activities were examined. We demonstrated 2-5A synthesizing activities of OASs from the marine sponge Tedania ignis, a representative of the phylogenetically oldest metazoan phylum (Porifera), from an invertebrate of the protostome lineage, the mollusk Mytilus californianus (Mollusca), and from a vertebrate species, a cartilaginous fish Leucoraja erinacea (Chordata). However, the expressed proteins from an amphibian, the salamander Ambystoma mexicanum (Chordata), and from a protozoan, the marine choanoflagellate Monosiga brevicollis (Choanozoa), did not show 2-5A synthesizing activity. Differently from other studied OASs, OAS from the marine sponge T. ignis was able to catalyze the formation of oligomers having both 2',5'- and 3',5'-phosphodiester linkages. Our data suggest that OASs from sponges and evolutionarily higher animals have similar activation mechanisms which still include different affinities and possibly different structural requirements for the activating RNAs. Considering their 2'- and 3'-specificities, sponge OASs could represent a link between evolutionarily earlier nucleotidyl transferases and 2'-specific OASs from higher animals.

  9. Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage.

    PubMed

    Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Kjaer, Karina Hansen; Justesen, Just; Kelve, Merike

    2014-02-01

    2',5'-Oligoadenylate synthetases (OASs) belong to the nucleotidyl transferase family together with poly(A) polymerases, CCA-adding enzymes and the recently discovered cyclic-GMP-AMP synthase (cGAS). Mammalian OASs have been thoroughly characterized as components of the interferon-induced antiviral system. The OAS activity and the respective genes were also discovered in marine sponges where the interferon system is absent. In this study the recombinant OASs from several multicellular animals and their closest unicellular relative, a choanoflagellate, were expressed in a bacterial expression system and their enzymatic activities were examined. We demonstrated 2-5A synthesizing activities of OASs from the marine sponge Tedania ignis, a representative of the phylogenetically oldest metazoan phylum (Porifera), from an invertebrate of the protostome lineage, the mollusk Mytilus californianus (Mollusca), and from a vertebrate species, a cartilaginous fish Leucoraja erinacea (Chordata). However, the expressed proteins from an amphibian, the salamander Ambystoma mexicanum (Chordata), and from a protozoan, the marine choanoflagellate Monosiga brevicollis (Choanozoa), did not show 2-5A synthesizing activity. Differently from other studied OASs, OAS from the marine sponge T. ignis was able to catalyze the formation of oligomers having both 2',5'- and 3',5'-phosphodiester linkages. Our data suggest that OASs from sponges and evolutionarily higher animals have similar activation mechanisms which still include different affinities and possibly different structural requirements for the activating RNAs. Considering their 2'- and 3'-specificities, sponge OASs could represent a link between evolutionarily earlier nucleotidyl transferases and 2'-specific OASs from higher animals. PMID:24184688

  10. Plants as sources of airborne bacteria, including ice nucleation-active bacteria.

    PubMed

    Lindemann, J; Constantinidou, H A; Barchet, W R; Upper, C D

    1982-11-01

    Vertical wind shear and concentration gradients of viable, airborne bacteria were used to calculate the upward flux of viable cells above bare soil and canopies of several crops. Concentrations at soil or canopy height varied from 46 colony-forming units per m over young corn and wet soil to 663 colony-forming units per m over dry soil and 6,500 colony-forming units per m over a closed wheat canopy. In simultaneous samples, concentrations of viable bacteria in the air 10 m inside an alfalfa field were fourfold higher than those over a field with dry, bare soil immediately upwind. The upward flux of viable bacteria over alfalfa was three- to fourfold greater than over dry soil. Concentrations of ice nucleation-active bacteria were higher over plants than over soil. Thus, plant canopies may constitute a major source of bacteria, including ice nucleation-active bacteria, in the air.

  11. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.

    PubMed

    Koo, Taeyoung; Lee, Jungjoon; Kim, Jin-Soo

    2015-06-01

    Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations.

  12. Stability and activity of alcohol dehydrogenases in W/O-microemulsions: enantioselective reduction including cofactor regeneration.

    PubMed

    Orlich, B; Berger, H; Lade, M; Schomäcker, R

    2000-12-20

    Microemulsions provide an interesting alternative to classical methods for the conversion of less water-soluble substrates by alcohol dehydrogenase, but until now stability and activity were too low for economically useful processes. The activity and stability of the enzymes are dependent on the microemulsion composition, mostly the water and the surfactant concentration. Therefore, it is necessary to know the exact phase behavior of a given microemulsion reaction system and the corresponding enzyme behavior therein. Because of their economic and ecologic suitability polyethoxylated fatty alcohols were investigated concerning their phase behavior and their compatibility with enzymes in ternary mixtures. The phase behavior of Marlipal O13-60 (C13EO6 in industrial quality)/cyclohexane/water and its effect on the activity and stability of alcohol dehydrogenase from Yeast (YADH) and horse liver (HLADH) and the carbonyl reductase from Candida parapsilosis (CPCR) is presented in this study. Beside the macroscopic phase behavior of the reaction system, the viscosity of the system indicates structural changes of aggregates in the microemulsion. The changes of the enzyme activities with the composition are discussed on the basis of transitions from reverse micelles to swollen reverse micelles and finally, the transition to the phase separation. The formate dehydrogenase from Candida boidinii was used for the NADH-regeneration during reduction reactions. While the formate dehydrogenase did not show any kinetic effect on the microemulsion composition, the other enzymes show significant changes of activity and stability varying the water or surfactant concentration of the microemulsion. Under certain conditions, stability could be maintained with HLADH for several weeks. Successful experiments with semi-batch processes including cofactor regeneration and product separation were performed.

  13. Appendix (image)

    MedlinePlus

    ... become infected. Although most people are familiar with appendicitis, it is a relatively rare disease. It is ... of the appendix (appendectomy). Recovery time for uncomplicated appendicitis is usually just three days.

  14. Kentucky Consumer & Homemaking Education. Appendix for Curriculum Guide.

    ERIC Educational Resources Information Center

    Bishop, Helen; And Others

    As the appendix for a series of curriculum guides for consumer and homemaking education on the secondary level in Kentucky, this booklet contains instructional activities for classroom use in conjunction with the units in the comprehensive curriculum guides. Included are games, puzzles, skits, quizzes, survey forms, checklists, and review sheets…

  15. The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

    PubMed Central

    Mock, Kerstin; Preca, Bogdan-Tiberius; Brummer, Tilman; Brabletz, Simone; Stemmler, Marc P.; Brabletz, Thomas

    2015-01-01

    Tumor cell invasion, dissemination and metastasis is triggered by an aberrant activation of epithelial-to-mesenchymal transition (EMT), often mediated by the transcription factor ZEB1. Disseminating tumor cells must acquire specific features that allow them to colonize at different organ sites. Here we identify a set of genes that is highly expressed in breast cancer bone metastasis and activated by ZEB1. This gene set includes various secreted factors, e.g. the BMP-inhibitor FST, that are described to reorganize the bone microenvironment. By inactivating BMP-signaling, BMP-inhibitors are well-known to induce osteolysis in development and disease. We here demonstrate that the expression of ZEB1 and BMP-inhibitors is correlated with bone metastasis, but not with brain or lung metastasis of breast cancer patients. In addition, we show that this correlated expression pattern is causally linked, as ZEB1 induces the expression of the BMP-inhibitors NOG, FST and CHRDL1 both by directly increasing their gene transcription, as well as by indirectly suppressing their reduction via miR-200 family members. Consequently, ZEB1 stimulates BMP-inhibitor mediated osteoclast differentiation. These findings suggest that ZEB1 is not only driving EMT, but also contributes to the formation of osteolytic bone metastases in breast cancer. PMID:25973542

  16. Preliminary Systems Design Study assessment report. Volume 8, Appendixes

    SciTech Connect

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex`s Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume of the Systems Design Study contain four Appendixes that were part of the study. Appendix A is an EG&G Idaho, Inc., report that represents a review and compilation of previous reports describing the wastes and quantities disposed in the Subsurface Disposal Area of the Idaho National Engineering Laboratory. Appendix B contains the process flowsheets considered in this study, but not selected for detailed analysis. Appendix C is a historical tabulation of radioactive waste incinerators. Appendix D lists Department of Energy facilities where cementation stabilization systems have been used.

  17. Be BOLD: Encouraging Girls to Include Unstructured Bouts of Physical Activity into Daily Routines

    ERIC Educational Resources Information Center

    Hill, Kory; Williams, Gwynne M.

    2014-01-01

    Adolescent girls are less active than their male counterparts and physical activity levels tend to decline as one ages. One of the goals of concerned physical educators is to promote a physically active lifestyle and to teach skills and promote behaviors that will allow students to be active both in and out of school. This article presents a…

  18. Active control of environmental noise, VIII: increasing the response to primary source changes including unpredictable noise

    NASA Astrophysics Data System (ADS)

    Wright, S. E.; Atmoko, H.; Vuksanovic, B.

    2004-07-01

    Conventional adaptive cancellation systems using traditional transverse finite impulse response (FIR) filters, together with least mean square (LMS) adaptive algorithms, well known in active noise control, are slow to adapt to primary source changes. This makes them inappropriate for cancelling rapidly changing noise, including unpredictable noise such as speech and music. Secondly, the cancelling structures require considerable computational processing effort to adapt to primary source and plant changes, particularly for multi-channel systems. This paper describes methods to increase the adaptive speed to primary source changes in large enclosed spaces and outdoor environments. A method is described that increases the response to time varying periodic noise using traditional transverse FIR filters. Here a multi-passband filter, with individual variable adaptive step sizes for each passband is automatically adjusted according to the signal level in each band. This creates a similar adaptive response for all frequencies within the total pass-band, irrespective of amplitude, minimizing the signal distortion and increasing the combined adaptive speed. Unfortunately, there is a limit to the adaptive speed using the above method as classical transverse FIR filters have a finite adaptive speed given by the stability band zero bandwidth. For rapidly changing periodic noise and unpredictable non-stationary noise, a rapid to instantaneous response is required. In this case the on-line adaptive FIR filters are dispensed with and replaced by a time domain solution that gives virtually instantaneous cancellation response (infinite adaptive speed) to primary source changes, and is computationally efficient.

  19. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  20. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  1. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  2. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  3. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  4. Environmental effects on components: A nonmandatory appendix for ASME Section III

    SciTech Connect

    Hill, R.S. III

    1995-12-01

    A nonmandatory appendix is being developed, by an ASME task group on environmental effects, to provide guidance on potential light water reactor service degradation mechanisms not explicitly covered by design requirements in Section 3 of the ASME Boiler and Pressure Vessel Code. Categories of degradation mechanisms addressed by the appendix include corrosion, embrittlement, fretting and wear, thermal fatigue, dynamic loading, and creep. For each damage mechanism, the appendix will address: description and experience; material selection, treatment and testing; operation and design Limitations; and mitigating actions and remedies. Awareness of these damage mechanisms is essential to planning in-service inspection and plant life extension activities. This paper presents the background for the nonmandatory appendix and discusses its expected content.

  5. Using Assistive Technology Adaptations To Include Students with Learning Disabilities in Cooperative Learning Activities.

    ERIC Educational Resources Information Center

    Bryant, Diane Pedrotty; Bryant, Brian R.

    1998-01-01

    Discusses a process for integrating technology adaptations for students with learning disabilities into cooperative-learning activities in terms of three components: (1) selecting adaptations; (2) monitoring use of adaptations during cooperative-learning activities; and (3) evaluating the adaptations' effectiveness. Barriers to and support systems…

  6. 32 CFR Appendix D to Subpart M of... - Unauthorized Activities in Maneuver Training Areas

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of alcoholic beverages. 2. Yakima Training Center: Civilian paramilitary activities and combat games... Center. Consumption of alcoholic beverages. 3. Camp Bonneville: Civilian paramilitary activities and... permits, obtained through the DEH Real Estate Office. Overnight camping. Consumption of...

  7. 32 CFR Appendix D to Subpart M of... - Unauthorized Activities in Maneuver Training Areas

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of alcoholic beverages. 2. Yakima Training Center: Civilian paramilitary activities and combat games... Center. Consumption of alcoholic beverages. 3. Camp Bonneville: Civilian paramilitary activities and... permits, obtained through the DEH Real Estate Office. Overnight camping. Consumption of...

  8. 32 CFR Appendix D to Subpart M of... - Unauthorized Activities in Maneuver Training Areas

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of alcoholic beverages. 2. Yakima Training Center: Civilian paramilitary activities and combat games... Center. Consumption of alcoholic beverages. 3. Camp Bonneville: Civilian paramilitary activities and... permits, obtained through the DEH Real Estate Office. Overnight camping. Consumption of...

  9. 32 CFR Appendix D to Subpart M of... - Unauthorized Activities in Maneuver Training Areas

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of alcoholic beverages. 2. Yakima Training Center: Civilian paramilitary activities and combat games... Center. Consumption of alcoholic beverages. 3. Camp Bonneville: Civilian paramilitary activities and... permits, obtained through the DEH Real Estate Office. Overnight camping. Consumption of...

  10. Diffractive laser beam homogenizer including a photo-active material and method of fabricating the same

    SciTech Connect

    Bayramian, Andy J; Ebbers, Christopher A; Chen, Diana C

    2014-05-20

    A method of manufacturing a plurality of diffractive optical elements includes providing a partially transmissive slide, providing a first piece of PTR glass, and directing first UV radiation through the partially transmissive slide to impinge on the first piece of PTR glass. The method also includes exposing predetermined portions of the first piece of PTR glass to the first UV radiation and thermally treating the exposed first piece of PTR glass. The method further includes providing a second piece of PTR glass and directing second UV radiation through the thermally treated first piece of PTR glass to impinge on the second piece of PTR glass. The method additionally includes exposing predetermined portions of the second piece of PTR glass to the second UV radiation, thermally treating the exposed second piece of PTR glass, and repeating providing and processing of the second piece of PTR glass using additional pieces of PTR glass.

  11. In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.

    PubMed

    Fujisaki, Ryuichi; Kamei, Kiyoko; Yamamura, Mariko; Nishiya, Hajime; Inouye, Shigeharu; Takahashi, Miki; Abe, Shigeru

    2012-03-01

    Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values. PMID:23082579

  12. In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.

    PubMed

    Fujisaki, Ryuichi; Kamei, Kiyoko; Yamamura, Mariko; Nishiya, Hajime; Inouye, Shigeharu; Takahashi, Miki; Abe, Shigeru

    2012-03-01

    Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values.

  13. Electrode including porous particles with embedded active material for use in a secondary electrochemical cell

    DOEpatents

    Vissers, Donald R.; Nelson, Paul A.; Kaun, Thomas D.; Tomczuk, Zygmunt

    1978-04-25

    Particles of carbonaceous matrices containing embedded electrode active material are prepared for vibratory loading within a porous electrically conductive substrate. In preparing the particles, active materials such as metal chalcogenides, solid alloys of alkali or alkaline earth metals along with other metals and their oxides in powdered or particulate form are blended with a thermosetting resin and particles of a volatile to form a paste mixture. The paste is heated to a temperature at which the volatile transforms into vapor to impart porosity at about the same time as the resin begins to cure into a rigid, solid structure. The solid structure is then comminuted into porous, carbonaceous particles with the embedded active material.

  14. Physical Activity Programs in Higher Education: Modifying Net/Wall Games to Include Individuals with Disabilities

    ERIC Educational Resources Information Center

    Braga, Luciana; Tracy, Julia F.; Taliaferro, Andrea R.

    2015-01-01

    The growing number of students with disabilities in higher education settings has presented challenges for instructors with regards to appropriate inclusion. Concerning physical activity courses in higher education, instructors may not have the knowledge or resources to make modifications and accommodations that will ultimately result in…

  15. Observing a fictitious stressful event: haematological changes, including circulating leukocyte activation.

    PubMed

    Mian, Rubina; Shelton-Rayner, Graham; Harkin, Brendan; Williams, Paul

    2003-03-01

    The aim of this study was to assess the effect of watching a psychological stressful event on the activation of leukocytes in healthy human volunteers. Blood samples were obtained from 32 healthy male and female subjects aged between 20 and 26 years before, during and after either watching an 83-minute horror film that none of the subjects had previously seen (The Texas Chainsaw Massacre, 1974) or by sitting quietly in a room (control group). Total differential cell counts, leukocyte activation as measured by the nitroblue tetrazolium (NBT) test, heart rate and blood pressure (BP) measurements were taken at defined time points. There were significant increases in peripheral circulating leukocytes, the number of activated circulating leukocytes, haemoglobin (Hb) concentration and haematocrit (Hct) in response to the stressor. These were accompanied by significant increases in heart rate, systolic and diastolic BP (P<0.05 from baseline). This is the first reported study on the effects of observing a psychologically stressful, albeit fictitious event on circulating leukocyte numbers and the state of leukocyte activation as determined by the nitrotetrazolium test.

  16. Sixty Minutes of Physical Activity per Day Included within Preschool Academic Lessons Improves Early Literacy

    ERIC Educational Resources Information Center

    Kirk, Stacie M.; Kirk, Erik P.

    2016-01-01

    Background: The effects of increases in physical activity (PA) on early literacy skills in preschool children are not known. Methods: Fifty-four African-American preschool children from a low socioeconomic urban Head Start participated over 8 months. A 2-group, quasi-experimental design was used with one preschool site participating in the PA…

  17. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities and Bibliography.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population concerns. Designed to educate general college audiences, it is also intended for use as a preservice course for teachers. In addition, the course can be modified for high school students. The course…

  18. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  19. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  20. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  1. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  2. Backyards and Butterflies: Ways to Include Children with Disabilities in Outdoor Activities.

    ERIC Educational Resources Information Center

    Greenstein, Doreen; And Others

    This sourcebook is designed for children, parents, and families, detailing ideas for outdoor play and learning activities, with emphasis on involving children with disabilities in outdoor play. A rural perspective permeates the guide, although each chapter contains ideas for making outdoor environments more accessible and safer for all children,…

  3. Beyond Right or Wrong: Challenges of Including Creative Design Activities in the Classroom

    ERIC Educational Resources Information Center

    Brennan, Karen

    2015-01-01

    In this article, we explore challenges encountered by K-12 educators in establishing classroom cultures that support creative learning activities with the Scratch programming language. Providing opportunities for students to understand and to build capacities for creative work was described by many of the teachers that we interviewed as a central…

  4. Space Resources for Teachers: Biology, Including Suggestions for Classroom Activities and Laboratory Experiments.

    ERIC Educational Resources Information Center

    Lee, Tom E.; And Others

    This compilation of resource units concerns the latest developments in space biology. Some of the topics included are oxygen consumption, temperature, radiation, rhythms, weightlessness, acceleration and vibration stress, toxicity, and sensory and perceptual problems. Many of the topics are interdisciplinary and relate biology, physiology,…

  5. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... relations purposes, including E-commerce (mail ordering through the Internet): Provided, That Credit-Back...-Back is requested. (e) The following requirements shall apply to Credit-Back for all promotional... and Canada, paragraph (e)(5) of this section shall also apply. (2) The clear and evident purpose...

  6. 12 CFR Appendix A to Part 610 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... responsible for verifying information; (iii) Is inputting information into an online application or other... activities in paragraph (b)(1) of this appendixin the course of carrying out employment duties, even if...

  7. In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp.

    PubMed

    Olsen, Steven C; Carlson, Steve A

    2015-01-01

    Plazomicin is a next-generation aminoglycoside with a potentially unique set of clinical characteristics compared with other aminoglycosides. This study assessed the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of plazomicin against 15 clinical isolates as well as three reference strains representing Brucella abortus, Brucella melitensis and Brucella suis. These data were compared with those obtained for six other aminoglycosides and two aminocyclitols. Plazomicin and gentamicin were the only drugs demonstrating bactericidal activity towards two of the three Brucella spp., whilst plazomicin was the only drug exhibiting bactericidal activity against B. suis. This is the first study to assess the bactericidal nature of plazomicin against Brucella spp. in vitro. PMID:25459738

  8. Activation calculations for trapped protons below 200 MeV: Appendix

    NASA Technical Reports Server (NTRS)

    Laird, C. E.

    1991-01-01

    Tables are given displaying of the results of the activation calculations of metal samples and other material aboard the Long Duration Exposure Facility-1 (LDEF-1) and Spacelab-2 with the computer program, PTRAP4. The computer printouts give the reaction, the reactant product, the proton reaction cross sections as a function of the energy of the incident protons, and the activation as a function of distance into the sample from the exposed surface.

  9. Activity of faropenem tested against Neisseria gonorrhoeae isolates including fluoroquinolone-resistant strains.

    PubMed

    Jones, Ronald N; Critchley, Ian A; Whittington, William L H; Janjic, Nebojsa; Pottumarthy, Sudha

    2005-12-01

    We evaluated the anti-gonococcal potency of faropenem along with 7 comparator reference antimicrobials against a preselected collection of clinical isolates. The 265 isolates were inclusive of 2 subsets: 1) 76 well-characterized resistant phenotypes of gonococcal strains (53 quinolone-resistant strains--31 with documented quinolone resistance-determining region changes from Japan, 15 strains resistant to penicillin and tetracycline, and 8 strains with intermediate susceptibility to penicillin) and 2) 189 recent isolates from clinical specimens in 2004 from 6 states across the United States where quinolone resistance is prevalent. Activity of faropenem was adversely affected by l-cysteine hydrochloride in IsoVitaleX (4-fold increase in [minimal inhibitory concentration] MIC50; 0.06 versus 0.25 microg/mL). The rank order of potency of the antimicrobials for the entire collection was ceftriaxone (MIC90, 0.06 microg/mL) > faropenem (0.25 microg/mL) > azithromycin (0.5 microg/mL) > cefuroxime (1 microg/mL) > tetracycline (2 microg/mL) > penicillin = ciprofloxacin = levofloxacin (4 microg/mL). Using MIC90 for comparison, faropenem was 4-fold more potent than cefuroxime (0.25 versus 1 microg/mL), but was 4-fold less active than ceftriaxone (0.25 versus 0.06 microg/mL). Although the activity of faropenem was not affected by either penicillinase production (MIC90, 0.12 microg/mL, penicillinase-positive) or increasing ciprofloxacin MIC (0.25 microg/mL, ciprofloxacin-resistant), increasing penicillin MIC was associated with an increase in MIC90 values (0.016 microg/mL for penicillin-susceptible to 0.25 microg/mL for penicillin-resistant strains). Among the recent (2004) clinical gonococcal isolates tested, reduced susceptibility to penicillins, tetracycline, and fluoroquinolones was high (28.0-94.2%). Geographic distribution of the endemic resistance rates of gonococci varied considerably, with 16.7-66.7% of the gonococcal isolates being ciprofloxacin-resistant in Oregon

  10. Phytophthora infestans Has a Plethora of Phospholipase D Enzymes Including a Subclass That Has Extracellular Activity

    PubMed Central

    Meijer, Harold J. G.; Hassen, Hussen Harrun; Govers, Francine

    2011-01-01

    In eukaryotes phospholipase D (PLD) is involved in many cellular processes. Currently little is known about PLDs in oomycetes. Here we report that the oomycete plant pathogen Phytophthora infestans has a large repertoire of PLDs divided over six subfamilies: PXPH-PLD, PXTM-PLD, TM-PLD, PLD-likes, and type A and B sPLD-likes. Since the latter have signal peptides we developed a method using metabolically labelled phospholipids to monitor if P. infestans secretes PLD. In extracellular medium of ten P. infestans strains PLD activity was detected as demonstrated by the production of phosphatidic acid and the PLD specific marker phosphatidylalcohol. PMID:21423760

  11. Phytophthora infestans has a plethora of phospholipase D enzymes including a subclass that has extracellular activity.

    PubMed

    Meijer, Harold J G; Hassen, Hussen Harrun; Govers, Francine

    2011-01-01

    In eukaryotes phospholipase D (PLD) is involved in many cellular processes. Currently little is known about PLDs in oomycetes. Here we report that the oomycete plant pathogen Phytophthora infestans has a large repertoire of PLDs divided over six subfamilies: PXPH-PLD, PXTM-PLD, TM-PLD, PLD-likes, and type A and B sPLD-likes. Since the latter have signal peptides we developed a method using metabolically labelled phospholipids to monitor if P. infestans secretes PLD. In extracellular medium of ten P. infestans strains PLD activity was detected as demonstrated by the production of phosphatidic acid and the PLD specific marker phosphatidylalcohol. PMID:21423760

  12. A Methodology for Post Operational Clean Out of a Highly Active Facility Including Solids Behaviour - 12386

    SciTech Connect

    Edmondson, Michael J.; Ward, Tracy R.; Maxwell, Lisa J.

    2012-07-01

    The Highly Active Liquor Evaporation and Storage (HALES) plant at Sellafield handles acidic fission product containing liquor with typical activities of the order of 18x10{sup 9} Bq/ml. A strategy experimental feedback approach has been used to establish a wash regime for the Post Operational Clean Out (POCO) of the oldest storage tanks for this liquor. Two different wash reagents have been identified as being potentially suitable for removal of acid insoluble fission product precipitates. Ammonium carbamate and sodium carbonate yield similar products during the proposed wash cycle. The proposed wash reagents provide dissolution of caesium phosphomolybdate (CPM) and zirconium molybdate (ZM) solid phases but yields a fine, mobile precipitate of metal carbonates from the Highly Active Liquor (HAL) supernate. Addition of nitric acid to the wash effluent can cause CPM to precipitate where there is sufficient caesium and phosphorous available. Where they are not present (from ZM dissolution) the nitric acid addition initially produces a nitrate precipitate which then re-dissolves, along with the metal carbonates, to give a solid-free solution. The different behaviour of the two solids during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing the rheology of ZM sediments through doping with tellurium or particular organic acids. Two different wash reagents have been identified as being potentially suitable for the POCO of HALES Oldside HASTs. AC and SC both yield similar products during the proposed wash cycle. However, the different behaviour of the two principle HAL solids, CPM and ZM, during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing its rheology through doping with tellurium or certain

  13. 32 CFR Appendix C to Subpart M of... - Authorized Activities for Maneuver Training Area Access

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., blackberries, apples and other vegetation Photography Hiking 2. Yakima Training Center: Military Training (FL... activities Observation of wildlife and vegetation Photography Hiking Camping, per Paragraph 6 3. Camp...-commercial picking of ferns, mushrooms, blackberries, apples and other vegetation Photography Hiking...

  14. 32 CFR Appendix C to Subpart M of... - Authorized Activities for Maneuver Training Area Access

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., blackberries, apples and other vegetation Photography Hiking 2. Yakima Training Center: Military Training (FL... activities Observation of wildlife and vegetation Photography Hiking Camping, per Paragraph 6 3. Camp...-commercial picking of ferns, mushrooms, blackberries, apples and other vegetation Photography Hiking...

  15. 32 CFR Appendix C to Subpart M of... - Authorized Activities for Maneuver Training Area Access

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., blackberries, apples and other vegetation Photography Hiking 2. Yakima Training Center: Military Training (FL... activities Observation of wildlife and vegetation Photography Hiking Camping, per Paragraph 6 3. Camp...-commercial picking of ferns, mushrooms, blackberries, apples and other vegetation Photography Hiking...

  16. 32 CFR Appendix C to Subpart M of... - Authorized Activities for Maneuver Training Area Access

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., blackberries, apples and other vegetation Photography Hiking 2. Yakima Training Center: Military Training (FL... activities Observation of wildlife and vegetation Photography Hiking Camping, per Paragraph 6 3. Camp...-commercial picking of ferns, mushrooms, blackberries, apples and other vegetation Photography Hiking...

  17. 32 CFR Appendix C to Subpart M of... - Authorized Activities for Maneuver Training Area Access

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., blackberries, apples and other vegetation Photography Hiking 2. Yakima Training Center: Military Training (FL... activities Observation of wildlife and vegetation Photography Hiking Camping, per Paragraph 6 3. Camp...-commercial picking of ferns, mushrooms, blackberries, apples and other vegetation Photography Hiking...

  18. 48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... collaboration between all participating parties (USAID, host country, and contractor) at important stages... collaboration with eligible Title XII institutions and LDC counterparts for a problem-solving type activity to... identification. After the host government has indicated a desire for U.S. collaboration on a particular...

  19. 32 CFR Appendix D to Subpart M of... - Unauthorized Activities in Maneuver Training Areas

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Lewis: Civilian paramilitary activities and combat games. Off-pavement motorcycle riding. Off-road.... Off-pavement motorcycle riding. Off-road vehicle operation. Hang gliding. Ultralight aircraft flying... combat games. Off-pavement motorcycle riding. Off-road vehicle operation. Hang gliding....

  20. 14 CFR Appendix C to Part 1215 - Typical User Activity Timeline

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... mission model. 3 years before launch (Ref. § 1215.109(c). Submit general user requirements to permit preliminary planning. Begin payment for pre-mission activities (Ref. § 1215.115(b)(5)). 18 months before... development of operational documents and ICD's. (Ref. § 1215.109(e)). If appropriate, initiate action with...

  1. 48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... problem areas of great complexity and varying uncertainty. Other types of technical assistance, which are... and the USAID field mission has determined that the proposed activity is consistent with its program... Agreement and other pertinent documentation. The field review will normally serve as the occasion...

  2. 48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... problem areas of great complexity and varying uncertainty. Other types of technical assistance, which are... and the USAID field mission has determined that the proposed activity is consistent with its program... Agreement and other pertinent documentation. The field review will normally serve as the occasion...

  3. 12 CFR Appendix A to Part 1008 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... aid in the understanding of activities that would cause an individual to fall within or outside the... responsible for verification, an individual can still “take a residential mortgage loan application” even if...) Generally describes for a borrower or prospective borrower the loan application process without a...

  4. 12 CFR Appendix A to Part 1008 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... aid in the understanding of activities that would cause an individual to fall within or outside the... responsible for verification, an individual can still “take a residential mortgage loan application” even if...) Generally describes for a borrower or prospective borrower the loan application process without a...

  5. 12 CFR Appendix A to Part 1008 - Examples of Mortgage Loan Originator Activities

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... aid in the understanding of activities that would cause an individual to fall within or outside the... responsible for verification, an individual can still “take a residential mortgage loan application” even if...) Generally describes for a borrower or prospective borrower the loan application process without a...

  6. 48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... decision for itself in collaboration with, but independent of, the requesting host government. (Normally... the second until it has exercised its independent judgment based on the product of the first plus any... purposes, ultimate outputs, types of activity and available financing. With these key variables for...

  7. Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

    SciTech Connect

    Michael Kruzic

    2007-09-01

    Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolition (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.

  8. LIPID PEROXIDATION GENERATES BIOLOGICALLY ACTIVE PHOSPHOLIPIDS INCLUDING OXIDATIVELY N-MODIFIED PHOSPHOLIPIDS

    PubMed Central

    Davies, Sean S.; Guo, Lilu

    2014-01-01

    Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease. PMID:24704586

  9. 32 CFR Appendix D to Part 169a - Commercial Activities Management Information System (CAMIS)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... Army Corps of Engineers (USACE) Civil Works Command code. The code established by the DoD Component..., “Facilities Engineering Package,” “Installation Bus Service,” or “Motor Pool”). Use a clear title, not..., including civil service pay increases, but excluding increases associated with new mission requirements...

  10. 17 CFR Appendix A to Part 255 - Reporting and Recordkeeping Requirements for Covered Trading Activities

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... positions: risk factors with respect to the related commodities set out in 17 CFR 20.2, the maturity of the... and Position Limits and Usage; • Risk Factor Sensitivities; • Value-at-Risk and Stress VaR... below, including “Risk Factor Sensitivities” and “Value-at-Risk and Stress Value-at-Risk,” relate to...

  11. Design of a high-lift experiment in water including active flow control

    NASA Astrophysics Data System (ADS)

    Beutel, T.; Sattler, S.; El Sayed, Y.; Schwerter, M.; Zander, M.; Büttgenbach, S.; Leester-Schädel, M.; Radespiel, R.; Sinapius, M.; Wierach, P.

    2014-07-01

    This paper describes the structural design of an active flow-control experiment. The aim of the experiment is to investigate the increase in efficiency of an internally blown Coanda flap using unsteady blowing. The system uses tailor-made microelectromechanical (MEMS) pressure sensors to determine the state of the oncoming flow and an actuated lip to regulate the mass flow and velocity of a stream near a wall over the internally blown flap. Sensors and actuators are integrated into a highly loaded system that is extremely compact. The sensors are connected to a bus system that feeds the data into a real-time control system. The piezoelectric actuators using the d 33 effect at a comparable low voltage of 120 V are integrated into a lip that controls the blowout slot height. The system is designed for closed-loop control that efficiently avoids flow separation on the Coanda flap. The setup is designed for water-tunnel experiments in order to reduce the free-stream velocity and the system’s control frequency by a factor of 10 compared with that in air. This paper outlines the function and verification of the system’s main components and their development.

  12. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase

    PubMed Central

    Sahonero-Canavesi, Diana X.; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M.; Geiger, Otto

    2016-01-01

    Summary Phospholipids are well known for their membrane forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth. PMID:25711932

  13. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase.

    PubMed

    Sahonero-Canavesi, Diana X; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M; Geiger, Otto

    2015-09-01

    Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth.

  14. Modeling the development of biofilm density including active bacteria, inert biomass, and extracellular polymeric substances.

    PubMed

    Laspidou, Chrysi S; Rittmann, Bruce E

    2004-01-01

    We present the unified multi-component cellular automaton (UMCCA) model, which predicts quantitatively the development of the biofilm's composite density for three biofilm components: active bacteria, inert or dead biomass, and extracellular polymeric substances. The model also describes the concentrations of three soluble organic components (soluble substrate and two types of soluble microbial products) and oxygen. The UMCCA model is a hybrid discrete-differential mathematical model and introduces the novel feature of biofilm consolidation. Our hypothesis is that the fluid over the biofilm creates pressures and vibrations that cause the biofilm to consolidate, or pack itself to a higher density over time. Each biofilm compartment in the model output consolidates to a different degree that depends on the age of its biomass. The UMCCA model also adds a cellular automaton algorithm that identifies the path of least resistance and directly moves excess biomass along that path, thereby ensuring that the excess biomass is distributed efficiently. A companion paper illustrates the trends that the UMCCA model is able to represent and shows a comparison with experimental results. PMID:15276752

  15. Ozone control of biological activity during Earth's history, including the KT catastrophe

    NASA Technical Reports Server (NTRS)

    Sheldon, W. R.

    1994-01-01

    There have been brief periods since the beginning of the Cambrian some 600 m.y. ago when mass extinctions destroyed a significant fraction of living species. The most widely studied of these events is the catastrophe at the KT boundary that ended the long dominance of the dinosaurs. In addition to mass extinctions, there is another profound discontinuity in the history of Earth's biota, the explosion of life at the end of the Precambrian era which is an episode that is not explained well at all. For some 3 b.y. before the Cambrian, life had been present on Earth, but maintained a low level of activity which is an aspect of the biota that is puzzling, especially during the last two-thirds of that period. During the last 2 b.y. before the Cambrian, conditions at the Earth's surface were suitable for a burgeoning of the biota, according to most criteria: the oceans neither boiled nor were fozen solid during this time, and the atmosphere contained sufficient O for the development of animals. The purpose of this paper is to suggest that mass extinctions and the lackluster behavior of the Precambrian biota share a common cause: an inadequate amount of ozone in the atmosphere.

  16. Report on the remedial investigation of Bear Creek Valley at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Volume 2: Appendix A -- Waste sites, source terms, and waste inventory report; Appendix B -- Description of the field activities and report database; Appendix C -- Characterization of hydrogeologic setting report

    SciTech Connect

    1996-09-01

    This Remedial Investigation (RI) Report characterizes the nature and extent of contamination, evaluates the fate and transport of contaminants, and assesses risk to human health and the environment resulting from waste disposal and other US Department of Energy (DOE) operations in Bear Creek Valley (BCV). BCV, which is located within the DOE Oak Ridge Reservation (ORR) encompasses multiple waste units containing hazardous and radioactive wastes arising from operations at the adjacent Oak Ridge Y-12 Plant. The primary waste units discussed in this RI Report are the S-3 Site, Oil Landfarm (OLF), Boneyard/Burnyard (BYBY), Sanitary Landfill 1 (SL 1), and Bear Creek Burial Grounds (BCBG). These waste units, plus the contaminated media resulting from environmental transport of the wastes from these units, are the subject of this RI. This BCV RI Report represents the first major step in the decision-making process for the BCV watershed. The RI results, in concert with the follow-on FS will form the basis for the Proposed Plan and Record of Decision for all BCV sites. This comprehensive decision document process will meet the objectives of the watershed approach for BCV. Appendix A includes descriptions of waste areas and estimates of the current compositions of the wastes. Appendix B contains an extensive database of environmental data for the Bear Creek Valley Characterization Area. Information is also presented about the number and location of samples collected, the analytes examined, and the extent of data validation. Appendix C describes the hydrogeologic conceptual model for Bear Creek Valley. This model is one of the principal components of the conceptual site models for contaminant transport in BCV.

  17. Radio Properties of Low Redshift Broad Line Active Galactic Nuclei Including Multiple Component Radio Sources

    NASA Astrophysics Data System (ADS)

    Rafter, Stephen E.

    2010-01-01

    We present results on the radio properties of a low redshift (z < 0.35) sample of 8434 broad line active galactic nuclei (AGNs) from the Sloan Digital Sky Survey after correlating the optical sources with radio sources in the Faint Images of the Radio Sky at Twenty-Centimeters survey. We find that 10% of our sample has radio emission < 4" away from the optical counterpart (core-only sources), and 1% has significant extended emission that must be taken into account when calculating the total radio luminosity (multi-component sources). Association of the extended radio emission is established by the proximity to the optical source, physical connection of jets and lobes, or large scale symmetry like in classic FRIIs. From these data we find an FRI/FRII luminosity dividing line like that found by Fanaroff & Riley (1974), where we use our core-only sources as proxies for FRIs, and our multi-component sources for the FRIIs. We find a bimodal distribution for the radio loudness (R = L(radio)/L(opt)) where the lower radio luminosity core-only sources appear as a population separate from the multi-component extended sources, compared with no evidence for bimodality when just the core-only sources are used. We also find that a log(R) value of 1.75 is well suited to separate the FRIs from the FRIIs, and that the R bimodality seen here is really a manifestation of the FRI/FRII break originally found by Fanaroff & Riley (1974). We find modest trends in the radio loud fraction as a function of Eddington ratio and black hole mass, where the fraction of RL AGNs decreases with increasing Eddington ratio, and increases when the black hole mass is above 2 x 108 solar masses.

  18. Should Physical Activity Be Included in Nutrition Education? A Comparison of Nutrition Outcomes with and without In-Class Activities

    ERIC Educational Resources Information Center

    Palmer-Keenan, Debra M.; Corda, Kirsten

    2014-01-01

    Limited-resource adults' dietary intakes and nutrition behaviors improve as a result of Expanded Food and Nutrition Education Program (EFNEP)/Supplemental Nutrition Assistance Program Education (SNAP-Ed) participation; however, physical activity education is needed for improved health. The experimental study reported here assessed if spending…

  19. Development of an oregano-based ointment with anti-microbial activity including activity against methicillin-resistant Staphlococcus aureus.

    PubMed

    Eng, William; Norman, Robert

    2010-04-01

    Increasing antibiotic resistance has prompted a search for new compounds with anti-microbial activity. In the authors' previous study, oregano extract was identified as one of the most potent anti-microbial compounds. The disk diffusion method was employed to assess the degree of inhibition against various microorganisms, and the bacteriostatic or bactericidal mechanism of action. Disk diffusion studies showed that oregano was found to be bacteriostatic for Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus, (MRSA) but bacteriocidal for seven other microorganisms. Pseudomonas aeruginosa could not be inhibited by oregano. An ointment consisting of 1-10% oregano could inhibit most organisms except for Proteus mirabilis and Proteus vulgaris, which required 20% and Pseudomonas which could not be inhibited even at the highest concentration of 80%. Oregano extracts can be formulated into an ointment that shows broad antimicrobial activity. Additional testing to assess tissue toxicity and other adverse reactions would be needed prior to human testing.

  20. Space shuttle/food system study. Volume 2, Appendix A: Active heating system-screening analysis. Appendix B: Reconstituted food heating techniques analysis

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Technical data are presented which were used to evaluate active heating methods to be incorporated into the space shuttle food system design, and also to evaluate the relative merits and penalties associated with various approaches to the heating of rehydrated food during space flight. Equipment heating candidates were subject to a preliminary screening performed by a selection rationale process which considered the following parameters; (1) gravitational effect; (2) safety; (3) operability; (4) system compatibility; (5) serviceability; (6) crew acceptability; (7) crew time; (8) development risk; and (9) operating cost. A hot air oven, electrically heated food tray, and microwave oven were selected for further consideration and analysis. Passive, semi-active, and active food preparation approaches were also studied in an effort to determine the optimum method for heating rehydrated food. Potential complexity, cost, vehicle impact penalties, and palatability were considered in the analysis. A summary of the study results is provided along with cost estimates for each of the potential sytems

  1. Columbia River System Operation Review : Final Environmental Impact Statement, Appendix J: Recreation.

    SciTech Connect

    Columbia River System Operation Review

    1995-11-01

    This Appendix J of the Final Environmental Impact Statement for the Columbia River System discusses impacts on the recreational activities in the region. Major sections include the following: scope and processes; recreation in the Columbia River Basin today - by type, location, participation, user characteristics, factors which affect usage, and managing agencies; recreation analysis procedures and methodology; and alternatives and their impacts.

  2. U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)

    USGS Publications Warehouse

    Tony K. Meunier Edited by Williams, Richard S.; Ferrigno, Jane G.

    2007-01-01

    international) programs in biology, geology, geophysics, hydrology, and mapping. Therefore, the USGS was the obvious choice for these tasks, because it already had a professional staff of experienced mapmakers, scientists, and program managers with the foresight, dedication, and understanding of the need for accurate maps to support the science programs in Antarctica when asked to do so by the U.S. National Academy of Sciences. Public Laws 85-743 and 87-626, signed in August 1958, and in September 1962, respectively, authorized the Secretary, U.S. Department of the Interior, through the USGS, to support mapping and scientific work in Antarctica (Meunier, 1979 [2007], appendix A). Open-File Report 2006-1116 includes scanned facsimiles of postal cachets. It has become an international practice to create postal cachets to commemorate special events and projects in Antarctica. A cachet is defined as a seal or commemorative design printed or stamped on an envelope to mark a philatelic or special event. The inked impression illustrates to the scientist, historian, stamp collector, and general public the multidisciplinary science projects staffed by USGS and collaborating scientists during the field season. Since 1960, philatelic cachets have been created by team members for each USGS field season and, in most cases, these cachets depict the specific geographic areas and field season program objectives. The cachets become a convenient documentation of the people, projects, and geographic places of interest for that year. Because the cachets are representative of USGS activities, each year's cachet is included as a digital facsimile in that year's Open-File Report. In the 1980s, multiple USGS cachets were prepared each year, one for use by the winter team at Amundsen-Scott South Pole Station and the other for the project work areas of the austral summer field season programs.

  3. Effects of Leisure Education Programme Including Sportive Activities on Perceived Freedom in Leisure of Adolescents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Ertuzun, Ezgi

    2015-01-01

    The objective of this experimental study is to determine the effect of leisure education programme including sportive activities on the perceived freedom in leisure of adolescents with mild intellectual disabilities. The research was designed with an experimental group (n = 37) and a control group (n = 34), and was conducted among a total of 71…

  4. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  5. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  6. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  7. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  8. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  9. A lipid chemotactic factor from anaerobic coryneform bacteria including Corynebacterium parvum with activity for macrophages and monocytes.

    PubMed Central

    Russell, R J; McInroy, R J; Wilkinson, P C; White, R G

    1976-01-01

    A lipid with chemoattractant (chemotactic) activity for mouse and guinea-pig macrophages and for human blood monocytes is released by anaerobic coryneform bacteria (including Corynebacterium parvum). The active lipid is associated with fibrillar structures which lie on the outside of the bacterial cell and are released spontaneously during growth. The lipid can also be extracted easily by a number of methods. The fibrils are loosely associated with a capsule-like structure composed largely of polysaccharide. Purification of the active lipid was achieved by chloroform-methanol extraction of the whole organisms yielding a chloroform-soluble fraction attracting mononuclear phagocytes at concentrations around 10 microgram/ml. The infra-red spectrum of this material showed lipid but no peptide or sugar. Thin-layer chromatography yielded twelve spots of which three had chemoattractant properties. The most active of these gave staining reactions consistent with the presence of phospholipid, the other two probably contained free fatty acids and triglycerides. Thin-layer electrophoresis also yielded an active phosphorus-containing spot. Saturated fatty acids of chain lengths found in the anaerobic coryne forms had weak monocyte-attractant activity. As the active material was progressively purified, its activity as a monocyte attractant weakened. Images Figure 2 Figure 3 Figure 4 PMID:1027716

  10. U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)

    USGS Publications Warehouse

    Tony K. Meunier Edited by Williams, Richard S.; Ferrigno, Jane G.

    2007-01-01

    international) programs in biology, geology, geophysics, hydrology, and mapping. Therefore, the USGS was the obvious choice for these tasks, because it already had a professional staff of experienced mapmakers, scientists, and program managers with the foresight, dedication, and understanding of the need for accurate maps to support the science programs in Antarctica when asked to do so by the U.S. National Academy of Sciences. Public Laws 85-743 and 87-626, signed in August 1958, and in September 1962, respectively, authorized the Secretary, U.S. Department of the Interior, through the USGS, to support mapping and scientific work in Antarctica (Meunier, 1979 [2007], appendix A). Open-File Report 2006-1116 includes scanned facsimiles of postal cachets. It has become an international practice to create postal cachets to commemorate special events and projects in Antarctica. A cachet is defined as a seal or commemorative design printed or stamped on an envelope to mark a philatelic or special event. The inked impression illustrates to the scientist, historian, stamp collector, and general public the multidisciplinary science projects staffed by USGS and collaborating scientists during the field season. Since 1960, philatelic c

  11. 49 CFR Appendix B to Part 21 - Activities to Which This Part Applies When a Primary Objective of the Federal Financial...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DEPARTMENT OF TRANSPORTATION-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 21, App. B Appendix... Assistance Is To Provide Employment 1. Appalachia Regional Development Act of 1965 (40 U.S.C. App. 1 et seq.). ... Primary Objective of the Federal Financial Assistance Is To Provide Employment B Appendix......

  12. In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains.

    PubMed

    Kohira, Naoki; West, Joshua; Ito, Akinobu; Ito-Horiyama, Tsukasa; Nakamura, Rio; Sato, Takafumi; Rittenhouse, Stephen; Tsuji, Masakatsu; Yamano, Yoshinori

    2015-11-16

    S-649266 is a novel siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. Two sets of clinical isolate collections were used to evaluate the antimicrobial activity of S-649266 against Enterobacteriaceae. These sets included 617 global isolates collected between 2009 and 2011 and 233 β-lactamase-identified isolates, including 47 KPC-, 49 NDM-, 12 VIM-, and 8 IMP-producers. The MIC90 values of S-649266 against the first set of Escherichia coli, Klebsiella pneumoniae, Serratia marcescens, Citrobacter freundii, Enterobacter aerogenes, and Enterobacter cloacae isolates were all ≤1 μg/ml, and there were only 8 isolates (1.3%) among these 617 clinical isolates with MIC values of ≥8 μg/ml. In the second set, the MIC values of S-649266 were ≤4 μg/ml against 109 strains among 116 KPC-producing and class B (metallo) carbapenemase-producing strains. In addition, S-649266 showed MIC values of ≤2 μg/ml against each of the 13 strains that produced other types of carbapenemases such as SME, NMC, and OXA-48. The mechanisms of the decreased susceptibility of 7 class B carbapenemase-producing strains with MIC values of ≥16 μg/ml are uncertain. This is the first report to demonstrate that S-649266, a novel siderophore cephalosporin, has significant antimicrobial activity against Enterobacteriaceae, including strains that produce carbapenemases such as KPC and NDM-1.

  13. Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City.

    PubMed

    Abdallah, Marie; Olafisoye, Olawole; Cortes, Christopher; Urban, Carl; Landman, David; Quale, John

    2015-03-01

    Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene. PMID:25534744

  14. The NLP toxin family in Phytophthora sojae includes rapidly evolving groups that lack necrosis-inducing activity.

    PubMed

    Dong, Suomeng; Kong, Guanghui; Qutob, Dinah; Yu, Xiaoli; Tang, Junli; Kang, Jixiong; Dai, Tingting; Wang, Hai; Gijzen, Mark; Wang, Yuanchao

    2012-07-01

    Necrosis- and ethylene-inducing-like proteins (NLP) are widely distributed in eukaryotic and prokaryotic plant pathogens and are considered to be important virulence factors. We identified, in total, 70 potential Phytophthora sojae NLP genes but 37 were designated as pseudogenes. Sequence alignment of the remaining 33 NLP delineated six groups. Three of these groups include proteins with an intact heptapeptide (Gly-His-Arg-His-Asp-Trp-Glu) motif, which is important for necrosis-inducing activity, whereas the motif is not conserved in the other groups. In total, 19 representative NLP genes were assessed for necrosis-inducing activity by heterologous expression in Nicotiana benthamiana. Surprisingly, only eight genes triggered cell death. The expression of the NLP genes in P. sojae was examined, distinguishing 20 expressed and 13 nonexpressed NLP genes. Real-time reverse-transcriptase polymerase chain reaction results indicate that most NLP are highly expressed during cyst germination and infection stages. Amino acid substitution ratios (Ka/Ks) of 33 NLP sequences from four different P. sojae strains resulted in identification of positive selection sites in a distinct NLP group. Overall, our study indicates that expansion and pseudogenization of the P. sojae NLP family results from an ongoing birth-and-death process, and that varying patterns of expression, necrosis-inducing activity, and positive selection suggest that NLP have diversified in function.

  15. 32 CFR Appendix C to Part 45 - DD Form 215

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false DD Form 215 C Appendix C to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to...

  16. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  17. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  18. 2 CFR Appendix A to Part 230 - General Principles

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...

  19. 32 CFR Appendix C to Part 45 - DD Form 215

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false DD Form 215 C Appendix C to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to...

  20. 32 CFR Appendix C to Part 45 - DD Form 215

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 215 C Appendix C to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to...

  1. Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells.

    PubMed

    Thougaard, Annemette V; Christiansen, Joan; Mow, Tomas; Hornberg, Jorrit J

    2014-12-01

    Genotoxicity is an unacceptable property for new drug candidates and we employ three screening assays during the drug discovery process to identify genotoxicity early and optimize chemical series. One of these methods is the flow cytometric in vitro micronucleus assay for which protocol optimizations have been described recently. Here, we report further validation of the assay in TK6 cells including assessment of metabolic activation. We first optimized assay conditions to allow for testing with and without metabolic activation in parallel in a 96-well plate format. Then, we tested a set of 48 compounds carefully selected to contain known in vivo genotoxins, nongenotoxins and drugs. Avoidance of irrelevant positives, a known issue with mammalian cell-based genotoxicity assays, is important to prevent early deselection of potentially promising compounds. Therefore, we enriched the validation set with compounds that were previously reported to produce irrelevant positive results in mammalian cell-based genotoxicity assays. The resulting dataset was used to set the relevant cut-off values for scoring a compound positive or negative, such that we obtained an optimal balance of high sensitivity (88%) and high specificity (87%). Finally, we tested an additional set of 16 drugs to further probe assay performance and 14 of them were classified correctly. To our knowledge, the present study is the most comprehensive validation of the in vitro flow cytometric micronucleus assay and the first to report parallel assessment with metabolic activation in reasonable throughput. The assay allows for rapidly screening novel compounds for genotoxicity and is therefore well-suited for use in early drug discovery projects. Environ.

  2. 12 CFR Appendix B to Part 216 - Sample Clauses

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CONSUMER FINANCIAL INFORMATION (REGULATION P) Pt. 216, App. B Appendix B to Part 216—Sample Clauses Link to... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Sample Clauses B Appendix B to Part 216 Banks... provided before January 1, 2011. Financial institutions, including a group of financial holding...

  3. 12 CFR Appendix B to Part 216 - Sample Clauses

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CONSUMER FINANCIAL INFORMATION (REGULATION P) Pt. 216, App. B Appendix B to Part 216—Sample Clauses Link to... 12 Banks and Banking 2 2011-01-01 2011-01-01 false Sample Clauses B Appendix B to Part 216 Banks... provided before January 1, 2011. Financial institutions, including a group of financial holding...

  4. 32 CFR Appendix D to Part 290 - Audit Working Papers

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 2 2013-07-01 2013-07-01 false Audit Working Papers D Appendix D to Part 290.... 290, App. D Appendix D to Part 290—Audit Working Papers (a) Definition (1) Audit working papers... interviews and inquiries, and other available sources. Audit working papers may also include contract...

  5. 32 CFR Appendix D to Part 290 - Audit Working Papers

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 2 2012-07-01 2012-07-01 false Audit Working Papers D Appendix D to Part 290.... 290, App. D Appendix D to Part 290—Audit Working Papers (a) Definition (1) Audit working papers... interviews and inquiries, and other available sources. Audit working papers may also include contract...

  6. 32 CFR Appendix D to Part 290 - Audit Working Papers

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 2 2014-07-01 2014-07-01 false Audit Working Papers D Appendix D to Part 290.... 290, App. D Appendix D to Part 290—Audit Working Papers (a) Definition (1) Audit working papers... interviews and inquiries, and other available sources. Audit working papers may also include contract...

  7. Appendix G: Geochemistry

    SciTech Connect

    Cantrell, Kirk J.; Serne, R. Jeffrey; Zachara, John M.; Krupka, Kenneth M.; Dresel, P. Evan; Brown, Christopher F.; Freshley, Mark D.

    2008-01-17

    This appendix discusses the geology of the Hanford Site and singe-shell tank (SST) waste management areas (WMAs). The purpose is to provide the most recent geochemical information available for the SST WMAs and the Integrated Disposal Facility. This appendix summarizes the information in the geochemistry data package for the SST WMAs.

  8. [Evaluation of an obesity prevention intervention which included nutrition education and physical activity applied in public schools of Santiago, Chile].

    PubMed

    Kain, Juliana; Leyton, Bárbara; Concha, Fernando; Weisstaub, Gerardo; Lobos, Luz; Bustos, Nelly; Vio, Fernando

    2012-03-01

    The main objective of this study was to assess the effectiveness of an obesity prevention intervention which included nutrition education and physical activity applied to low income Chilean children in a longitudinal three-year follow-up study. Participants included all 4-7 year old children from 7 public schools located in a low socioeconomic district of Santiago. The main aspects of the intervention were: training of teachers so they could apply an educational program on healthy eating, increase in physical education classes from 3 to 4 per week, and improvement of their quality. Weight, height, waist circumference (WC) and the 6-minute walk distance (6MWD) were assessed yearly in 597 children. We calculated BMI, BMI Z, % normal (N), overweight (OW) and obesity (OB), WC > 90th percentile (NHANES III) and fitness (6MWD/height). Annual changes in BMI Z, WC, 6MWD and fitness were assessed, using repeated measures ANOVA and the test of proportions. Knowledge in healthy eating was assessed during 2 of the 3 years. Results showed that % OB remained unchanged for 2 years (17%) but increased to 19.3% at follow-up. BMI Z increased from 0.3 to 0.38 (p = 0.052) in the N, remained unchanged in the OW, while decreasing significantly in the OB (2.73 to 2.41 p < 0.0001). % WC > 90 th percentile decreased in the OW and OB; 6 MWD was higher in the OW, but the increase in distance overtime was greater among the N. Overall fitness improved, however it was only significant among the N (p = 0.0002). There was a significant increase in food knowledge. We conclude that in spite of a decrease in BMI Z of the OB, an improvement in fitness in the N and food knowledge in all the children, obesity increased at follow-up. This study shows that in school-based obesity programs it is necessary to apply more intense interventions with another type of methodology; otherwise this condition will continue to rise.

  9. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  10. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  11. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  12. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  13. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  14. HEPS Inventory Tool: An Inventory Tool Including Quality Assessment of School Interventions on Healthy Eating and Physical Activity

    ERIC Educational Resources Information Center

    Dadaczynski, Kevin; Paulus, Peter; de Vries, Nanne; de Ruiter, Silvia; Buijs, Goof

    2010-01-01

    The HEPS Inventory Tool aims to support stakeholders working in school health promotion to promote high quality interventions on healthy eating and physical activity. As a tool it provides a step-by-step approach on how to develop a national or regional inventory of existing school based interventions on healthy eating and physical activity. It…

  15. Effects of restricted feeding on daily fluctuations of hepatic functions including p450 monooxygenase activities in rats.

    PubMed

    Hirao, Jun; Arakawa, Shingo; Watanabe, Kyoko; Ito, Kazumi; Furukawa, Tadashi

    2006-02-10

    Hepatic P450 monooxygenase activities, assessed by measurement of 7-alkoxycoumarin O-dealkylase (ACD) activities, show obvious daily fluctuations in male rats with high values during the dark period and low values during the light period. We have already confirmed that the ACD activities are controlled by the suprachiasmatic nucleus (SCN), which is well known as the oscillator of circadian rhythm. Recently, it is reported that circadian oscillators exist not only in the SCN but also in peripheral organs. To date, it is unclear which circadian oscillators predominantly drive the daily fluctuations of hepatic ACD activities. To address this question, we examined the effects of restricted feeding, which uncouples the circadian oscillators in the liver from the central pacemaker in the SCN, on the daily fluctuations in hepatic ACD activities in male rats. Here we show that restricted feeding inverts the oscillation phase of the daily fluctuations in hepatic ACD activities. Regarding the hepatic P450 content, there were no fluctuations between the light and dark periods under ad libitum and restricted feeding conditions. Therefore, it is considered that the daily fluctuations in hepatic ACD activities are predominantly driven by the circadian factors in peripheral organs rather than by the oscillator in the SCN directly.

  16. Present Status and Future Prospects of Geothermal Development in Italy with an Appendix on Reservoir Engineering

    SciTech Connect

    Cataldi, R.; Calamai, A.; Neri, G.; Manetti, G.

    1983-12-15

    This paper consists of two parts and an appendix. In the first part a review is made of the geothermal activity in Italy from 1975 to 1982, including electrical and non-electrical applications. Remarks then follow on the trends that occurred and the operational criteria that were applied in the same period, which can be considered a transitional period of geothermal development in Italy. Information on recent trends and development objectives up to 1990 are given in the second part of the paper, together with a summary on program activities in the various geothermal areas of Italy. The appendix specifically reviews the main reseroir engineering activities carried out in the past years and the problems likely to be faced in the coming years in developing Itallian fields.

  17. Antiviral activity of human Vδ2 T-cells against WNV includes both cytolytic and non-cytolytic mechanisms.

    PubMed

    Agrati, Chiara; Castilletti, Concetta; Cimini, Eleonora; Romanelli, Antonella; Lapa, Daniele; Quartu, Serena; Martini, Federico; Capobianchi, Maria Rosaria

    2016-04-01

    West Nile virus (WNV) causes a severe central nervous system infection in humans, primarily in the elderly and immunocompromised subjects. Human γδ T-cells play a critical role in the immune response against viruses, and studies of WNV meningoencephalitis in laboratory mice described a role of γδ T-cells in the protective immune response. Aim of this study was to analyze the cytolytic and non-cytolytic antiviral activity of human Vδ2 T-cells against WNV replication. The anti-WNV activity of soluble factor released by zoledronic acid (ZA)-activated Vδ2 T-cell lines and the cytotoxic capability of Vδ2 T-cell lines against WNV-infected cells were tested in vitro. The activation of Vδ2 T-cell lines was able to inhibit WNV replication through the release of soluble factors. IFN-γ is massively released by activated Vδ2 T-cell lines and is involved in the anti-WNV activity. Moreover, the Vδ2 T-cell lines can efficiently kill WNV-infected cells possibly through perforin-mediated mechanism. Altogether, our results provide insight into the effector functions of human Vδ2 T-cells against WNV. The possibility to target these cells by ZA, a commercially available drug used in humans, could potentially offer a new immunotherapeutic strategy for WNV infection. PMID:27196553

  18. 12 CFR Appendix C to Part 3 - Capital Adequacy Guidelines for Banks: Internal-Ratings-Based and Advanced Measurement Approaches

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... subject to 12 CFR part 3, appendix B, calculates its risk-based capital requirements under this appendix, the bank must also refer to 12 CFR part 3, appendix B, for supplemental rules to calculate risk-based.... 1467a) provided all or substantially all of the holding company's activities are permissible for...

  19. Potash: a global overview of evaporate-related potash resources, including spatial databases of deposits, occurrences, and permissive tracts: Chapter S in Global mineral resource assessment

    USGS Publications Warehouse

    Orris, Greta J.; Cocker, Mark D.; Dunlap, Pamela; Wynn, Jeff C.; Spanski, Gregory T.; Briggs, Deborah A.; Gass, Leila; Bliss, James D.; Bolm, Karen S.; Yang, Chao; Lipin, Bruce R.; Ludington, Stephen; Miller, Robert J.; Slowakiewicz, Miroslaw

    2014-01-01

    This report describes a global, evaporite-related potash deposits and occurrences database and a potash tracts database. Chapter 1 summarizes potash resource history and use. Chapter 2 describes a global potash deposits and occurrences database, which contains more than 900 site records. Chapter 3 describes a potash tracts database, which contains 84 tracts with geology permissive for the presence of evaporite-hosted potash resources, including areas with active evaporite-related potash production, areas with known mineralization that has not been quantified or exploited, and areas with potential for undiscovered potash resources. Chapter 4 describes geographic information system (GIS) data files that include (1) potash deposits and occurrences data, (2) potash tract data, (3) reference databases for potash deposit and tract data, and (4) representative graphics of geologic features related to potash tracts and deposits. Summary descriptive models for stratabound potash-bearing salt and halokinetic potash-bearing salt are included in appendixes A and B, respectively. A glossary of salt- and potash-related terms is contained in appendix C and a list of database abbreviations is given in appendix D. Appendix E describes GIS data files, and appendix F is a guide to using the geodatabase.

  20. 14 CFR 440.11 - Duration of coverage for licensed launch, including suborbital launch, or permitted activities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... LICENSING FINANCIAL RESPONSIBILITY Financial Responsibility for Licensed and Permitted Activities § 440.11...; modifications. (a) Insurance coverage required under § 440.9, or other form of financial responsibility, shall... recovery; or (ii) The FAA's determination that risk to third parties and Government property as a result...

  1. Activated Notch1 Target Genes during Embryonic Cell Differentiation Depend on the Cellular Context and Include Lineage Determinants and Inhibitors

    PubMed Central

    Meier-Stiegen, Franziska; Schwanbeck, Ralf; Bernoth, Kristina; Martini, Simone; Hieronymus, Thomas; Ruau, David; Zenke, Martin; Just, Ursula

    2010-01-01

    Background Notch receptor signaling controls developmental cell fates in a cell-context dependent manner. Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the target genes that are directly activated by Notch in the respective tissues. Methodology/Principal Findings To analyze how Notch signaling mediates its context dependent function(s), we utilized a Tamoxifen-inducible system to activate Notch1 in murine embryonic stem cells at different stages of mesodermal differentiation and performed global transcriptional analyses. We find that the majority of genes regulated by Notch1 are unique for the cell type and vary widely dependent on other signals. We further show that Notch1 signaling regulates expression of genes playing key roles in cell differentiation, cell cycle control and apoptosis in a context dependent manner. In addition to the known Notch1 targets of the Hes and Hey families of transcriptional repressors, Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis. Conclusion/Significance We suggest that Notch signaling determines lineage decisions and expansion of stem cells by directly activating both key lineage specific transcription factors and their repressors (Id and Hes/Hey proteins) and propose a model by which Notch signaling regulates cell fate commitment and self renewal in dependence of the intrinsic and extrinsic cellular context. PMID:20628604

  2. 78 FR 78063 - Appendix 4 to Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Act for human food with respect to hazards other than intentional adulteration (78 FR 3646). Elsewhere... RA) (78 FR 3824). We conducted the qualitative risk assessment to identify activity/ food....regulations.gov and at...

  3. Weight management including dietary and physical activity advice provided by Australian physiotherapists: a pilot cross-sectional survey.

    PubMed

    Snodgrass, Suzanne J; Carter, Amy E; Guest, Maya; Collins, Clare E; James, Carole; Kable, Ashley K; Ashby, Samantha E; Plotnikoff, Ronald C

    2014-08-01

    Physiotherapists may have an impact on obesity prevention and treatment by providing nutrition and physical activity advice to overweight or obese clients; yet little is known about physiotherapists' beliefs and practices related to client weight management. The aim of this pilot study was to determine the practices, beliefs, attitudes and knowledge of physiotherapists regarding the provision of weight management advice to overweight or obese clients. Physiotherapists (n = 65) working in multiple practice settings completed a self-administered questionnaire. Logistic regression determined factors associated with the provision of dietary and physical activity advice for weight management. The majority of physiotherapists (n = 53 [81.5%]) believed providing weight management advice was within their scope of practice, yet only a minority had received training during their professional entry level education (n = 13 [20%]) or through professional development (n = 7 [11%]). Most physiotherapists (n = 55 [84.6%]) provided physical activity advice for weight management, but a minority (n = 27 [41.5%]) provided dietary advice. Having received training in weight management during their professional entry level education was associated with providing dietary advice (Odds ratio 8.8, 95% confidence interval 2.0-38.9, p = 0.004). Training in weight management may increase the likelihood of physiotherapists providing dietary advice, improving physiotherapists' management of obesity.

  4. The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA–Dependent Tel1 Activation

    PubMed Central

    Iwasaki, Daichi; Hayashihara, Kayoko; Shima, Hiroki; Higashide, Mika; Terasawa, Masahiro; Gasser, Susan M.; Shinohara, Miki

    2016-01-01

    Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex, and its function is critical for the primary step of DSB repair, whether by homologous recombination (HR) or non-homologous end joining. In human NBS1, mutations result truncation of the N-terminus region, which contains a forkhead-associated (FHA) domain, cause Nijmegen breakage syndrome. Here we show that the Xrs2 FHA domain of budding yeast is required both to suppress the imprecise repair of DSBs and to promote the robust activation of Tel1 in the DNA damage response pathway. The role of the Xrs2 FHA domain in Tel1 activation was independent of the Tel1-binding activity of the Xrs2 C terminus, which mediates Tel1 recruitment to DSB ends. Both the Xrs2 FHA domain and Tel1 were required for the timely removal of the Ku complex from DSB ends, which correlates with a reduced frequency of imprecise end-joining. Thus, the Xrs2 FHA domain and Tel1 kinase work in a coordinated manner to maintain DSB repair fidelity. PMID:26990569

  5. The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

    PubMed Central

    Bottardi, Stefania; Mavoungou, Lionel; Pak, Helen; Daou, Salima; Bourgoin, Vincent; Lakehal, Yahia A.; Affar, El Bachir; Milot, Eric

    2014-01-01

    IKAROS is a critical regulator of hematopoietic cell fate and its dynamic expression pattern is required for proper hematopoiesis. In collaboration with the Nucleosome Remodeling and Deacetylase (NuRD) complex, it promotes gene repression and activation. It remains to be clarified how IKAROS can support transcription activation while being associated with the HDAC-containing complex NuRD. IKAROS also binds to the Positive-Transcription Elongation Factor b (P-TEFb) at gene promoters. Here, we demonstrate that NuRD and P-TEFb are assembled in a complex that can be recruited to specific genes by IKAROS. The expression level of IKAROS influences the recruitment of the NuRD-P-TEFb complex to gene regulatory regions and facilitates transcription elongation by transferring the Protein Phosphatase 1α (PP1α), an IKAROS-binding protein and P-TEFb activator, to CDK9. We show that an IKAROS mutant that is unable to bind PP1α cannot sustain gene expression and impedes normal differentiation of IkNULL hematopoietic progenitors. Finally, the knock-down of the NuRD subunit Mi2 reveals that the occupancy of the NuRD complex at transcribed regions of genes favors the relief of POL II promoter-proximal pausing and thereby, promotes transcription elongation. PMID:25474253

  6. Simultaneous BVI noise and vibration reduction in rotorcraft using actively-controlled flaps and including performance considerations

    NASA Astrophysics Data System (ADS)

    Patt, Daniel A.

    This work presents the development and application of an active control approach for reduction of both vibration and noise induced by helicopter rotor blade vortex interaction (BVI). Control is implemented through single or dual actively controlled flaps (ACFs) on each blade. Low-speed helicopter flight is prone to severe BVI, resulting in elevated vibration and noise levels. Existing research has suggested that when some form of active control is used to reduce vibration, noise will increase and vice versa. The present research achieves simultaneous reduction of noise and vibration, and also investigates the physical sources of the observed reduction. The initial portion of this work focused on developing a tool for simulating helicopter noise and vibrations in the BVI flight regime. A method for predicting compressible unsteady blade surface pressure distribution on rotor blades was developed and combined with an enhanced free-wake model and an acoustic prediction tool with provisions for blade flexibility. These elements were incorporated within an aeroelastic analysis featuring fully coupled flap-lag-torsional blade dynamics. Subsequently, control algorithms were developed that were effective for reducing noise and vibration even in the nonlinear BVI flight regime; saturation limits were incorporated constraining flap deflections to specified limits. The resulting simulation was also validated with a wide range of experimental data, achieving excellent correlation. Finally, a number of active control studies were performed. Multi-component vibration reductions of 40--80% could be achieved, while incurring a small noise penalty. Noise was reduced using an onboard feedback microphone; reductions of 4--10 dB on the advancing side were observed on a plane beneath the rotor when using dual flaps. Finally, simultaneous noise and vibration reduction was studied. A reduction of about 5 dB in noise on the advancing side combined with a 60% reduction in vibration was

  7. Reading and the Kindergarten Child. Appendix.

    ERIC Educational Resources Information Center

    Clark County School District, Las Vegas, NV.

    GRADES OR AGES: Kindergarten. SUBJECT MATTER: Reading. ORGANIZATION AND PHYSICAL APPEARANCE: This document is the appendix of supplemental resources for use with the Kindergarten Reading Guide (SP 007 233). It has the following contents: Stage I which includes motor development, identification of self and surroundings, hand-eye and small muscle…

  8. The Influence of Organized Physical Activity (including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed Central

    Bernardoni, Brittney; Scerpella, Tamara A.; Rosenbaum, Paula F.; Kanaley, Jill A.; Raab, Lindsay N.; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N.

    2015-01-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semi-annual records of anthropometry, maturity and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year pre-menarche [predictor] and ~5 years post-menarche [dependent variable]). Regression analysis evaluated total adolescent inter-scan PA and PA over 3 maturity sub-phases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry and strength indices at non-dominant distal radius and femoral neck; 2) sub-head BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or post-menarche), baseline bone status, adult body size and inter-scan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p<0.07). Pre-menarcheal bone traits were strong predictors of most adult outcomes (semi-partial r2 = 0.21-0.59, p≤0.001). Adult 1/3 radius and sub-head BMC were predicted by both total PA and PA 1-3 years post-menarche (p<0.03). PA 3-5 years post-menarche predicted femoral narrow neck width, endosteal diameter and buckling ratio (p<0.05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females. PMID:25386845

  9. The Influence of Organized Physical Activity (Including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed

    Bernardoni, Brittney; Scerpella, Tamara A; Rosenbaum, Paula F; Kanaley, Jill A; Raab, Lindsay N; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N

    2015-05-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semiannual records of anthropometry, maturity, and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year premenarche [predictor] and ~5 years postmenarche [dependent variable]). Regression analysis evaluated total adolescent interscan PA and PA over 3 maturity subphases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry, and strength indices at nondominant distal radius and femoral neck; 2) subhead BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or postmenarche), baseline bone status, adult body size and interscan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p > .07). Premenarcheal bone traits were strong predictors of most adult outcomes (semipartial r2 = .21-0.59, p ≤ .001). Adult 1/3 radius and subhead BMC were predicted by both total PA and PA 1-3 years postmenarche (p < .03). PA 3-5 years postmenarche predicted femoral narrow neck width, endosteal diameter, and buckling ratio (p < .05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females. PMID:25386845

  10. 34 CFR Appendix A to Subpart B of... - Standards for Audit of Governmental Organizations, Programs, Activities, and Functions (GAO)

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... objectives of a particular program. 3. Previous involvement in a decisionmaking or management capacity in the... activities to be examined. 3. Denial of access to such sources of information as books, records, and... are involved either directly or indirectly in the government management process. To achieve...

  11. 34 CFR Appendix A to Subpart B of... - Standards for Audit of Governmental Organizations, Programs, Activities, and Functions (GAO)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... objectives of a particular program. 3. Previous involvement in a decisionmaking or management capacity in the... activities to be examined. 3. Denial of access to such sources of information as books, records, and... are involved either directly or indirectly in the government management process. To achieve...

  12. 12 CFR Appendix A to Part 242 - Financial Activities for Purposes of Title I of the Dodd-Frank Act

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... See also the Board's interpretation of bank management consulting advice (12 CFR 225.131). (1) On any... securities of the client institution; or (2) Allows a management official, as defined in 12 CFR 212.2(h), of... Board's interpretation on courier activities (12 CFR 225.129), which sets forth conditions for...

  13. New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

    PubMed Central

    La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

    2014-01-01

    We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro the Hedgehog signaling pathway, strongly reducing luciferase activity in SAG treated NIH3T3 Shh-Light II cells, and inhibited the growth of medulloblastoma D283 cells at nanomolar concentrations. ARAPs 22 and 27 represent a new potent class of tubulin polymerization and cancer cell growth inhibitors with the potential to inhibit the Hedgehog signaling pathway. PMID:25025991

  14. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.

  15. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation. PMID:26866597

  16. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay

    PubMed Central

    Mahoney, J. Matthew; Titiz, Ali S.; Hernan, Amanda E.; Scott, Rod C.

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation. PMID:26866597

  17. Product and rate determinations with chemically activated nucleotides in the presence of various prebiotic materials, including other mono- and polynucleotides

    NASA Technical Reports Server (NTRS)

    Kanavarioti, A.; Alberas, D. J.; Rosenbach, M. T.; Bernasconi, C. F.; Chang, S.

    1991-01-01

    We are investigating the reactions of ImpN's in the presence of a number of prebiotically plausible materials, such as metal ions, phosphate, amines and other nucleotides and hope to learn more about the stability/reactivity of ImpN's in a prebiotic aqueous environment. We find that, in the presence of phosphate, ImpN's form substantial amounts of diphosphate nucleotides. These diphosphate nucleotides are not very good substrates for template directed reactions, but are chemically activated and are known to revert to the phosphoimidazolides in the presence of imidazole under solid state conditions. With respect to our studies of the oligomerization reaction, the determination of the dimerization rate constant of a specific ImpN (guanosine 5'-phospho 2 methylimidazolide) both in the absence and the presence of the template leads to the conclusion that at 37 C the dimerization is not template directed, although the subsequent polymerization steps are. In other words, this specific polynucleotide synthesizing system favors the elongation of oligonucleotides as compared with the formation of dimers and trimers. This favoring of the synthesis of long as opposed to short oligonucleotides may be regarded as a rudimentary example of natural selection at the molecular level.

  18. A comparison of methods of assessment of body composition including neutron activation analysis of total body nitrogen.

    PubMed

    Lukaski, H C; Mendez, J; Buskirk, E R; Cohn, S H

    1981-08-01

    Fourteen healthy men underwent determinations of total body nitrogen (TBN) by prompt gamma neutron activation analysis and total body potassium (TBK) by whole body counting to estimate the muscle and nonmuscle components of the fat-free body mass (FFBM) and their protein contents. Comparison of FFBM estimated from TBN and TBK (60.6 +/- 6.9 kg, mean +/- SD), densitometry (62.3 +/- 7.1 kg), TBK alone (62.2 +/- 8.0 kg) and TBW (63.9 +/- 7.8 kg) showed no differences among the techniques. Similarly, there were neither differences in fat mass nor percent body fat among the methods. Analysis of the chemical composition of FFBM of this group showed TBK/FFBM = 62.6 +/- 2.3 mEq/kg, TBW/FFBM = 74.6 +/- 0.2%, TBN/FFBM = 32.74 +/- 1.09 g/kg, protein/FFBM = 20.5+/- 0.7%. The calculated mineral content of the FFBM was 6.4%. These values are strikingly similar to the values calculated by direct chemical analysis. It was concluded that the combined TBN-TBK method is a valid technique for estimating body composition in man.

  19. Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

    PubMed Central

    2015-01-01

    DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of gene expression and represent valuable targets in cancer chemotherapy. A number of nucleoside DNMT inhibitors (DNMTi) have been studied in cancer, including in cancer stem cells, and two of them (azacytidine and decitabine) have been approved for treatment of myelodysplastic syndromes. However, only a few non-nucleoside DNMTi have been identified so far, and even fewer have been validated in cancer. Through a process of hit-to-lead optimization, we report here the discovery of compound 5 as a potent non-nucleoside DNMTi that is also selective toward other AdoMet-dependent protein methyltransferases. Compound 5 was potent at single-digit micromolar concentrations against a panel of cancer cells and was less toxic in peripheral blood mononuclear cells than two other compounds tested. In mouse medulloblastoma stem cells, 5 inhibited cell growth, whereas related compound 2 showed high cell differentiation. To the best of our knowledge, 2 and 5 are the first non-nucleoside DNMTi tested in a cancer stem cell line. PMID:24387159

  20. Novel stilbenoids, including cannabispiradienone glycosides, from Tragopogon tommasinii (Asteraceae, Cichorieae) and their potential anti-inflammatory activity.

    PubMed

    Granica, Sebastian; Piwowarski, Jakub P; Randazzo, Antonio; Schneider, Peter; Żyżyńska-Granica, Barbara; Zidorn, Christian

    2015-09-01

    A phytochemical investigation of Tragopogon tommasinii Sch.Bip. (Asteraceae, Cichorieae) yielded a total of 21 natural products, two simple phenolic acids (4-hydroxybenzoic acid and p-coumaric acid), four caffeic acid derivatives (chlorogenic acid, 3-O-caffeoylquinic acid, 3,5-O-dicaffeoylquinic acid, and 4,5-O-dicaffeoylquinic acid), six flavonoids (luteolin, luteolin 7-O-glucoside, vitexin, orientin, quercetin 3-O-glucoside, and isorhamnetin 3-O-glucoside), three simple bibenzyls [2-carboxyl-5-hydroxy-3-methoxy-4'-β-glucopyranosyl-oxybibenzyl, 3-caffeoyl-(9→5)-β-apiosyl-(1→6)-β-glucopyranosyloxy-5,4'-dihydroxy-3'-methoxybibenzyl, 3-caffeoyl-(9→5)-β-apiosyl-(1→6)-β-glucopyranosyloxy-4'-dihydroxy-5,3'-dimethoxybibenzyl], three phtalides [3-(4-β-glucopyranosyloxybenzyl)-7-hydroxy-5-methoxyphtalide, 7-β-glucopyranosyloxy-(S)-3-(4-hydroxybenzyl)-5-methoxyphtalide, and 7-(1→6)-α-rhamnosyl-β-glucopyranosyloxy-(S)-3-(4-hydroxybenzyl)-5-methoxyphtalide], two cannabispiradienone derivatives [3-O-β-glucopyranosyldemethoxycannabispiradienone and 3-caffeoyl-(9→5)-β-apiosyl-(1→6)-β-glucopyranosyloxydemethoxycannabispiradienone], and tetra-N-coumaroyl spermine. The three bibenzyls, the latter two benzylphthalides, and both cannabispiradienone derivatives represent new natural compounds and all compounds, except the caffeic acid derivatives and the flavonoids were new for T. tommasinii. The structures were established by HR mass spectrometry, extensive 1D and 2D NMR spectroscopy, and CD spectroscopy. Moreover, the potential anti-inflammatory activities of the new compounds were assayed using human neutrophils and their production of IL-1b, IL-8, TNF-α and MMP-9 as well as the expression of TLR-4, respectively.

  1. Synthesis Gas Demonstration Plant, Baskett, Kentucky: environmental report. [Contains chapter 4 and appendix 4A

    SciTech Connect

    1980-01-01

    This volume contains chapter 4 and Appendix 4A which include descriptions of use of adjacent land and water (within miles of the proposed site), baseline ecology, air quality, meteorology, noise, hydrology, water quality, geology, soils and socio-economic factors. Appendix 4A includes detailed ecological surveys made in the area including the methods used. (LTN)

  2. Remedial action plan and site design for stabilization of the Inactive Uranium Mill Tailings Site, Maybell, Colorado. Final report, Appendixes to attachment 3

    SciTech Connect

    Not Available

    1994-06-01

    This document contains supporting appendices to attachment 3 for the remedial action and site stabilization plan for Maybell, Colorado UMTRA site. Appendix A includes the Hydrological Services Calculations and Appendix B contains Ground Water Quality by Location data.

  3. High water-stressed population estimated by world water resources assessment including human activities under SRES scenarios

    NASA Astrophysics Data System (ADS)

    Kiguchi, M.; Shen, Y.; Kanae, S.; Oki, T.

    2009-04-01

    In an argument of the reduction and the adaptation for the climate change, the evaluation of the influence by the climate change is important. When we argue in adaptation plan from a damage scale and balance with the cost, it is particularly important. Parry et al (2001) evaluated the risks in shortage of water, malaria, food, the risk of the coast flood by temperature function and clarified the level of critical climate change. According to their evaluation, the population to be affected by the shortage of water suddenly increases in the range where temperature increases from 1.5 to 2.0 degree in 2080s. They showed how much we need to reduce emissions in order to draw-down significantly the number at risk. This evaluation of critical climate change threats and targets of water shortage did not include the water withdrawal divided by water availability. Shen et al (2008a) estimated the water withdrawal of projection of future world water resources according to socio-economic driving factors predicted for scenarios A1b, A2, B1, and B2 of the Special Report on Emission Scenarios (SRES). However, these results were in function of not temperature but time. The assessment of the highly water-stressed population considered the socioeconomic development is necessary for a function of the temperature. Because of it is easy to understand to need to reduce emission. We present a multi-GCM analysis of the global and regional populations lived in highly water-stressed basin for a function of the temperature using the socioeconomic data and the outputs of GCMs. In scenario A2, the population increases gradually with warming. On the other hand, the future projection population in scenario A1b and B1 increase gradually until the temperature anomaly exceeds around from +1 to +1.5 degree. After that the population is almost constant. From Shen et al (2008b), we evaluated the HWSP and its ratio in the world with temperature function for scenarios A1B, A2, and B1 by the index of W

  4. Dynamical Evolution of the Inner Heliosphere Approaching Solar Activity Maximum: Interpreting Ulysses Observations Using a Global MHD Model. Appendix 1

    NASA Technical Reports Server (NTRS)

    Riley, Pete; Mikic, Z.; Linker, J. A.

    2003-01-01

    In this study we describe a series of MHD simulations covering the time period from 12 January 1999 to 19 September 2001 (Carrington Rotation 1945 to 1980). This interval coincided with: (1) the Sun s approach toward solar maximum; and (2) Ulysses second descent to the southern polar regions, rapid latitude scan, and arrival into the northern polar regions. We focus on the evolution of several key parameters during this time, including the photospheric magnetic field, the computed coronal hole boundaries, the computed velocity profile near the Sun, and the plasma and magnetic field parameters at the location of Ulysses. The model results provide a global context for interpreting the often complex in situ measurements. We also present a heuristic explanation of stream dynamics to describe the morphology of interaction regions at solar maximum and contrast it with the picture that resulted from Ulysses first orbit, which occurred during more quiescent solar conditions. The simulation results described here are available at: http://sun.saic.com.

  5. Lawrence Berkeley National Laboratory 1995 site environmental report: Volume 2, Data appendix

    SciTech Connect

    1996-07-01

    Ernest Orlando Lawrence Berkeley National Laboratory presents Volume II, Data Appendix as a reference document to supplement the 1995 Site Environmental Report. Volume II contains the raw environmental monitoring and sampling data used to generate many of the summary results included in the main report. Supplemental data is provided for sitewide activities involving the media of stack and ambient air quality, rainwater, surface water, stormwater, wastewater, and soil and sediment. Volume II also contains supplemental data on the special preoperational monitoring study for the new Hazardous Waste Handling Facility. The Table of Contents provides a cross-reference to the data tables of the main report and this appendix. Data are given in System International (SI) units.

  6. Appendixes L-P. Vol. II, A Plan for Managing the Development, Implementation and Operation of a Model Elementary Teacher Education Program.

    ERIC Educational Resources Information Center

    Oregon Coll. of Education, Monmouth.

    Five appendixes make up this part of the final report on the elementary teacher education program. Appendix L is a summary chart of the orientation meetings, giving dates, locations, and participants. Appendix M is a listing of the seven school districts actively participating in the OCE coalition, with a brief description of their essential…

  7. A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

    PubMed

    Bloem, Esther; Meems, Henriet; van den Biggelaar, Maartje; Mertens, Koen; Meijer, Alexander B

    2013-09-01

    A recent chemical footprinting study in our laboratory suggested that region 1803-1818 might contribute to A2 domain retention in activated factor VIII (FVIIIa). This site has also been implicated to interact with activated factor IX (FIXa). Asn-1810 further comprises an N-linked glycan, which seems incompatible with a role of the amino acids 1803-1818 for FIXa or A2 domain binding. In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803-1810 and 1811-1818 are replaced by the corresponding residues of factor V (FV). Enzyme kinetic studies showed that only FVIII/FV 1811-1818 has a decreased apparent binding affinity for FIXa. Flow cytometry analysis indicated that fluorescent FIXa exhibits impaired complex formation with only FVIII/FV 1811-1818 on lipospheres. Site-directed mutagenesis revealed that Phe-1816 contributes to the interaction with FIXa. To evaluate FVIIIa stability, the FVIII/FV chimeras were activated by thrombin, and the decline in cofactor function was followed over time. FVIII/FV 1803-1810 and FVIII/FV 1811-1818 but not FVIII-N1810C showed a decreased FVIIIa half-life. However, when the FVIII variants were activated in presence of FIXa, only FVIII/FV 1811-1818 demonstrated an enhanced decline in cofactor function. Surface plasmon resonance analysis revealed that the FVIII variants K1813A/K1818A, E1811A, and F1816A exhibit enhanced dissociation after activation. The results together demonstrate that the glycan at 1810 is not involved in FVIII cofactor function, and that Phe-1816 of region 1811-1818 contributes to FIXa binding. Both regions 1803-1810 and 1811-1818 contribute to FVIIIa stability.

  8. A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

    PubMed

    Bloem, Esther; Meems, Henriet; van den Biggelaar, Maartje; Mertens, Koen; Meijer, Alexander B

    2013-09-01

    A recent chemical footprinting study in our laboratory suggested that region 1803-1818 might contribute to A2 domain retention in activated factor VIII (FVIIIa). This site has also been implicated to interact with activated factor IX (FIXa). Asn-1810 further comprises an N-linked glycan, which seems incompatible with a role of the amino acids 1803-1818 for FIXa or A2 domain binding. In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803-1810 and 1811-1818 are replaced by the corresponding residues of factor V (FV). Enzyme kinetic studies showed that only FVIII/FV 1811-1818 has a decreased apparent binding affinity for FIXa. Flow cytometry analysis indicated that fluorescent FIXa exhibits impaired complex formation with only FVIII/FV 1811-1818 on lipospheres. Site-directed mutagenesis revealed that Phe-1816 contributes to the interaction with FIXa. To evaluate FVIIIa stability, the FVIII/FV chimeras were activated by thrombin, and the decline in cofactor function was followed over time. FVIII/FV 1803-1810 and FVIII/FV 1811-1818 but not FVIII-N1810C showed a decreased FVIIIa half-life. However, when the FVIII variants were activated in presence of FIXa, only FVIII/FV 1811-1818 demonstrated an enhanced decline in cofactor function. Surface plasmon resonance analysis revealed that the FVIII variants K1813A/K1818A, E1811A, and F1816A exhibit enhanced dissociation after activation. The results together demonstrate that the glycan at 1810 is not involved in FVIII cofactor function, and that Phe-1816 of region 1811-1818 contributes to FIXa binding. Both regions 1803-1810 and 1811-1818 contribute to FVIIIa stability. PMID:23884417

  9. A3 Domain Region 1803–1818 Contributes to the Stability of Activated Factor VIII and Includes a Binding Site for Activated Factor IX

    PubMed Central

    Bloem, Esther; Meems, Henriet; van den Biggelaar, Maartje; Mertens, Koen; Meijer, Alexander B.

    2013-01-01

    A recent chemical footprinting study in our laboratory suggested that region 1803–1818 might contribute to A2 domain retention in activated factor VIII (FVIIIa). This site has also been implicated to interact with activated factor IX (FIXa). Asn-1810 further comprises an N-linked glycan, which seems incompatible with a role of the amino acids 1803–1818 for FIXa or A2 domain binding. In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803–1810 and 1811–1818 are replaced by the corresponding residues of factor V (FV). Enzyme kinetic studies showed that only FVIII/FV 1811–1818 has a decreased apparent binding affinity for FIXa. Flow cytometry analysis indicated that fluorescent FIXa exhibits impaired complex formation with only FVIII/FV 1811–1818 on lipospheres. Site-directed mutagenesis revealed that Phe-1816 contributes to the interaction with FIXa. To evaluate FVIIIa stability, the FVIII/FV chimeras were activated by thrombin, and the decline in cofactor function was followed over time. FVIII/FV 1803–1810 and FVIII/FV 1811–1818 but not FVIII-N1810C showed a decreased FVIIIa half-life. However, when the FVIII variants were activated in presence of FIXa, only FVIII/FV 1811–1818 demonstrated an enhanced decline in cofactor function. Surface plasmon resonance analysis revealed that the FVIII variants K1813A/K1818A, E1811A, and F1816A exhibit enhanced dissociation after activation. The results together demonstrate that the glycan at 1810 is not involved in FVIII cofactor function, and that Phe-1816 of region 1811–1818 contributes to FIXa binding. Both regions 1803–1810 and 1811–1818 contribute to FVIIIa stability. PMID:23884417

  10. Management of Appendix Cancer.

    PubMed

    Kelly, Kaitlyn J

    2015-12-01

    Primary cancers of the appendix are rare and are frequently diagnosed after surgery for appendicitis, presumed ovarian primary malignancy, or other indications. Primary appendix cancers are histologically diverse, and classification of these tumors has historically been confusing because of the nonstandardized nomenclature that is used. This review aimed to describe the epidemiology, presentation, workup, staging, and management of primary appendix cancers using current, recommended nomenclature. For this purpose, tumors were broadly classified as colonic-type or mucinous adenocarcinoma, goblet cell adenocarcinoma, or neuroendocrine carcinoma. Signet ring cell carcinoma was not regarded as an individual entity. The presence of signet ring cells is a histologic feature that may or may not be present in colonic-type or mucinous adenocarcinoma. The management of primary appendix cancer is complex and is dependent on the histologic subtype and extent of disease. Randomized, prospective trials do not exist for these rare tumors and management is largely guided by retrospective data expert consensus guidelines, which are summarized here.

  11. Appendix E: Geology

    SciTech Connect

    Reidel, Steve; Chamness, Mickie A.

    2008-01-17

    This appendix provides a detailed description of geology under the Central Plateau of the Hanford Site, emphasizing the areas around tank farms. It is to be published by client CH2M HILL Hanford Group, Inc., as part of a larger, multi-contractor technical report.

  12. School Facilities. Appendix A.

    ERIC Educational Resources Information Center

    Howell, Penny; Miller, Barbara; Krantzler, Nora

    1997-01-01

    This appendix to the theme issue summarizes the challenges of providing and maintaining educational facilities, discussing the maintenance of existing buildings and the need for new ones. Possible sources of needed funds are considered, and the equity problems related to school facilities are reviewed, emphasizing the problems of urban schools.…

  13. Preschool Curriculum: A Child Centered Curriculum of Concepts and Activities Including All of the CDA Functional Areas--Bi-lingual and Home Activities.

    ERIC Educational Resources Information Center

    Cunningham, Dorothy, Comp.

    This preschool resource curriculum, intended for use in a Head Start center, was written to correspond with a work plan and curriculum for children 3 to 5 years of age. The units included in the curriculum guide are aimed at integrating growth experiences with the learning of basic skills. Each of the 16 units contains material related to each of…

  14. Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge.

    PubMed

    Tara, S; Elcock, A H; Kirchhoff, P D; Briggs, J M; Radic, Z; Taylor, P; McCammon, J A

    1998-12-01

    It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavior of the ligand within the active site gorge of acetylcholinesterase. Negatively charged residues near the gorge opening not only attract positively charged ligands from solution to the enzyme, but can also restrict the motion of the ligand once it is inside of the gorge. We use Brownian dynamics techniques to calculate the rate constant kon, for wild type and mutant acetylcholinesterase with a positively charged ligand. These calculations are performed by allowing the ligand to diffuse within the active site gorge. This is an extension of previously reported work in which a ligand was allowed to diffuse only to the enzyme surface. By setting the reaction criteria for the ligand closer to the active site, better agreement with experimental data is obtained. Although a number of residues influence the movement of the ligand within the gorge, Asp74 is shown to play a particularly important role in this function. Asp74 traps the ligand within the gorge, and in this way helps to ensure a reaction.

  15. A poultry-intestinal isolate of Campylobacter jejuni produces a bacteriocin (CUV-3) active against a range of Gram positive bacterial pathogens including Clostridium perfringens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A newly isolated bacteriocin, CUV-3, produced by a poultry cecal isolate of Campylobacter jejuni strain CUV-3 had inhibitory activity against several Gram positive bacteria including Clostridium perfringens (38 strains), Staphylococcus aureus, Staph.epidermidis and Listeria monocytogenes. The pept...

  16. Including Youth with Intellectual Disabilities in Health Promotion Research: Development and Reliability of a Structured Interview to Assess the Correlates of Physical Activity among Youth

    ERIC Educational Resources Information Center

    Curtin, Carol; Bandini, Linda G.; Must, Aviva; Phillips, Sarah; Maslin, Melissa C. T.; Lo, Charmaine; Gleason, James M.; Fleming, Richard K.; Stanish, Heidi I.

    2016-01-01

    Background: The input of youth with intellectual disabilities in health promotion and health disparities research is essential for understanding their needs and preferences. Regular physical activity (PA) is vital for health and well-being, but levels are low in youth generally, including those with intellectual disabilities. Understanding the…

  17. 32 CFR Appendix B to Part 45 - DD Form 214ws

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false DD Form 214ws B Appendix B to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. B Appendix B to...

  18. 32 CFR Appendix B to Part 45 - DD Form 214ws

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false DD Form 214ws B Appendix B to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. B Appendix B to...

  19. 32 CFR Appendix E to Part 275 - Obtaining Access for Foreign Intelligence, Foreign Counterintelligence, and International...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Foreign Counterintelligence, and International Terrorist Activities or Investigations E Appendix E to Part..., App. E Appendix E to Part 275—Obtaining Access for Foreign Intelligence, Foreign Counterintelligence... tabulation of the occasions in E. An intelligence organization requesting financial records under paragraph...

  20. 32 CFR Appendix A to Part 203 - Technical Assistance for Public Participation Request Form

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Technical Assistance for Public Participation Request Form A Appendix A to Part 203 National Defense Department of Defense (Continued) OFFICE OF THE... DEFENSE ENVIRONMENTAL RESTORATION ACTIVITIES Pt. 203, App. A Appendix A to Part 203—Technical...

  1. 23 CFR Appendix F to Part 1200 - PLANNING AND ADMINISTRATION (P&A) COSTS

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false PLANNING AND ADMINISTRATION (P&A) COSTS F APPENDIX F TO... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F APPENDIX F TO PART 1200—PLANNING AND ADMINISTRATION (P&A) COSTS (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total...

  2. 23 CFR Appendix F to Part 1200 - Planning and Administration (P&A) Costs

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Planning and Administration (P&A) Costs F Appendix F to... HIGHWAY SAFETY GRANT PROGRAMS Pt. 1200, App. F Appendix F to Part 1200—Planning and Administration (P&A) Costs (a) Policy. Federal participation in P&A activities shall not exceed 50 percent of the total...

  3. 32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to...

  4. 32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to...

  5. 32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to...

  6. 32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to...

  7. 32 CFR Appendix E to Part 275 - Obtaining Access for Foreign Intelligence, Foreign Counterintelligence, and International...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Foreign Counterintelligence, and International Terrorist Activities or Investigations E Appendix E to Part..., App. E Appendix E to Part 275—Obtaining Access for Foreign Intelligence, Foreign Counterintelligence... tabulation of the occasions in E. An intelligence organization requesting financial records under paragraph...

  8. 20 CFR Appendix A to Subpart F of... - U.S. Seaports

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false U.S. Seaports A Appendix A to Subpart F of Part 655 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY... Longshore Activities in U.S. Ports Pt. 655, Subpt. F, App. A Appendix A to Subpart F of Part...

  9. 24 CFR Appendix B to Part 1000 - IHBG Block Grant Formula Mechanisms

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false IHBG Block Grant Formula Mechanisms B Appendix B to Part 1000 Housing and Urban Development REGULATIONS RELATING TO HOUSING AND URBAN... URBAN DEVELOPMENT NATIVE AMERICAN HOUSING ACTIVITIES Pt. 1000, App. B Appendix B to Part 1000—IHBG...

  10. 32 CFR Appendix A to Part 1292 - Section 21 of the Internal Security Act of 1950

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Section 21 of the Internal Security Act of 1950 A Appendix A to Part 1292 National Defense Other Regulations Relating to National Defense DEFENSE LOGISTICS AGENCY MISCELLANEOUS SECURITY OF DLA ACTIVITIES AND RESOURCES Pt. 1292, App. A Appendix A to...

  11. 20 CFR Appendix A to Subpart F of... - U.S. Seaports

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false U.S. Seaports A Appendix A to Subpart F of Part 655 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY... Longshore Activities in U.S. Ports Pt. 655, Subpt. F, App. A Appendix A to Subpart F of Part...

  12. Measurement of factor VIII activity using one-stage clotting assay: a calibration curve has not to be systematically included in each run.

    PubMed

    Lattes, S; Appert-Flory, A; Fischer, F; Jambou, D; Toulon, P

    2011-01-01

    Coagulation factor VIII (FVIII) is usually evaluated using activated partial thromboplastin time-based one-stage clotting assays. Guidelines for clotting factor assays indicate that a calibration curve should be included each time the assay is performed. Therefore, FVIII measurement is expensive, reagent- and time-consuming. The aim of this study was to compare FVIII activities obtained using the same fully automated assay that was calibrated once (stored calibration curve) or each time the assay was performed. Unique lots of reagents were used throughout the study. We analysed 255 frozen plasma samples from patients who were prescribed FVIII measurement including treated and untreated haemophilia A patients. Twenty-six runs were performed on a 28-week period, each including four lyophilized control and at most 10 patient plasma samples. In control samples, FVIII activities were not significantly different when the assay was performed using the stored calibration curve or was daily calibrated. The same applied to FVIII activities in patient plasma samples that were not significantly different throughout the measuring range of activities [68.3% (<1-179) vs. 67.6% (<1-177), P=0.48] and no relevant bias could be demonstrated when data were compared according to Bland and Altman. These results suggest that in the studied technical conditions, performing the FVIII assay using a stored calibration curve is reliable, for at least 6 months. Therefore, as far as the same lots of reagents are used, it is not mandatory to include a calibration curve each time the FVIII assay was performed. However, this strategy has to be validated if the assay is performed in different technical conditions.

  13. 40 CFR Appendix III to Part 1068 - High-Altitude Counties

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false High-Altitude Counties III Appendix... Appendix III to Part 1068—High-Altitude Counties In some cases the standard-setting part includes requirements or other specifications that apply for high-altitude counties. The following counties...

  14. 40 CFR Appendix III to Part 1068 - High-Altitude Counties

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false High-Altitude Counties III Appendix... Appendix III to Part 1068—High-Altitude Counties In some cases the standard-setting part includes requirements or other specifications that apply for high-altitude counties. The following counties...

  15. 40 CFR Appendix III to Part 1068 - High-Altitude Counties

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false High-Altitude Counties III Appendix... Appendix III to Part 1068—High-Altitude Counties In some cases the standard-setting part includes requirements or other specifications that apply for high-altitude counties. The following counties...

  16. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event recorder that includes a certified crashworthy event recorder memory module. This appendix prescribes...

  17. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event recorder that includes a certified crashworthy event recorder memory module. This appendix prescribes...

  18. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event recorder that includes a certified crashworthy event recorder memory module. This appendix prescribes...

  19. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event recorder that includes a certified crashworthy event recorder memory module. This appendix prescribes...

  20. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event recorder that includes a certified crashworthy event recorder memory module. This appendix prescribes...

  1. 49 CFR Appendix E to Part 238 - General Principles of Reliability-Based Maintenance Programs

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Maintenance Programs E Appendix E to Part 238 Transportation Other Regulations Relating to Transportation... STANDARDS Pt. 238, App. E Appendix E to Part 238—General Principles of Reliability-Based Maintenance... reliability beyond the design reliability. (e) When a maintenance program is developed, it includes tasks...

  2. 12 CFR Appendix A to Part 1026 - Effect on State Laws

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and Information (12 CFR Part 1070), all requests made, including any documents and other material... 12 Banks and Banking 9 2014-01-01 2014-01-01 false Effect on State Laws A Appendix A to Part 1026.... A Appendix A to Part 1026—Effect on State Laws Request for Determination A request for...

  3. 5 CFR Appendix A to Part 1320 - Agencies With Delegated Review and Approval Authority

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Approval Authority A Appendix A to Part 1320 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES CONTROLLING PAPERWORK BURDENS ON THE PUBLIC Pt. 1320, App. A Appendix A to Part 1320—Agencies With... established under 5 CFR 1320.8, including the seeking of public comment under 5 CFR 1320.8(d). In...

  4. 49 CFR Appendix E to Part 238 - General Principles of Reliability-Based Maintenance Programs

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Maintenance Programs E Appendix E to Part 238 Transportation Other Regulations Relating to Transportation... STANDARDS Pt. 238, App. E Appendix E to Part 238—General Principles of Reliability-Based Maintenance... reliability beyond the design reliability. (e) When a maintenance program is developed, it includes tasks...

  5. 19 CFR Appendix D to Part 113 - Importer Security Filing Bond

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) agrees to comply with all Importer Security Filing requirements set forth in 19 CFR part 149, including... 19 Customs Duties 1 2012-04-01 2012-04-01 false Importer Security Filing Bond D Appendix D to Part... THE TREASURY CUSTOMS BONDS Pt. 113, App. D Appendix D to Part 113—Importer Security Filing Bond...

  6. Relating the Capabilities of the Handicapped to the Human Attribute Requirements of Jobs: Appendixes.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    Twenty-five appendixes from a study attempting to match capabilities of the handicapped to the human attribute requirements of three jobs (general secretary, automotive mechanic, and business data programmer) are presented. Appendixes include information on such topics as data analysis for identification of key tasks; job descriptions for the…

  7. Small-Scale High Temperature Melter-1 (SSHTM-1) Data Package. Appendix B

    SciTech Connect

    1996-03-01

    This appendix provides the data for Alternate HTM Flowsheet 2 (Glycolic Acid) melter feed preparation activities in both the laboratory- and small-scale testing. The first section provides an outline of this appendix. The melter feed preparation data are presented in the next two main sections, laboratory melter feed preparation data and small-scale melter feed preparation data. Section 3.0 provides the laboratory data which is discussed in the main body of the Small-Scale High Temperature-1 (SSHTM-1) Data Package, milestone C95-02.02Y. Section 3.1 gives the flowsheet in outline form as used in the laboratory-scale tests. This section also includes the ``Laboratory Melter Feed Preparation Activity Log`` which gives A chronological account of the test in terms of time, temperature, slurry pH, and specific observations about slurry appearance, acid addition rates, and samples taken. The ``Laboratory Melter Feed Preparation Activity Log`` provides a road map to the reader by which all the activity and data from the laboratory can be easily accessed. A summary of analytical data is presented next, section 3.2, which covers starting materials and progresses to the analysis of the melter feed. The next section, 3.3, characterizes the off-gas generation that occurs during the slurry processing. The following section, 3.4, provides the rheology data gathered including gram waste oxide loading information for the various slurries tested. The final section, 3.5, includes data from standard crucible redox testing. Section 4.0 provides the small-scale data in parallel form to section 3.0. Section 5.0 concludes with the references for this appendix.

  8. 40 CFR 1502.18 - Appendix.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Appendix. 1502.18 Section 1502.18 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.18 Appendix. If an agency prepares an appendix to an environmental impact statement the appendix shall:...

  9. 40 CFR 1502.18 - Appendix.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Appendix. 1502.18 Section 1502.18 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.18 Appendix. If an agency prepares an appendix to an environmental impact statement the appendix shall:...

  10. [Ultrasonography of normal vermiform appendix].

    PubMed

    Ferri, E; Bonvicini, U; Pisani, M

    2001-01-01

    The aim of this study was the detection and visualisation of the normal vermiform appendix and its characteristics by ultrasonography in adults with no clinical suggestion of acute or chronic abdominal disease. A prospective study was performed in 200 subjects. The graded-compression ultrasonography technique was used to explore the lower right quadrant of the abdomen and the pelvis. The examination was performed using a 4 MHz sector array and 7.5 MHz linear array transducer. In a few cases, a 10 MHz linear array transducer was used. The appendix was visualized in 54% of patients. In all cases where the appendix was visualized it was found to be either on the ileo-psoas muscle or directly beneath the abdominal wall. The ileo-caecal valve was visualized in 78% of cases. The transverse diameter was found to be no greater than 6.5 mm except in three cases that had a diameters ranging from 7 to 9 mm. Diameter variability along the length of the same appendix was demonstrated in 5% of subjects. Wall thickness was no greater than 2.5 mm. Our experience suggests that graded-compression ultrasonography is a valuable procedure for detecting the vermiform appendix more frequently than has been previously reported. The patients physical constitution and the anatomical location of the vermiform appendix were found to be important factors affecting the ability to visualize the vermiform appendix. The ability to visualise the normal vermiform appendix ultrasonographically supports the clinical diagnosis and excludes acute appendicitis.

  11. 49 CFR Appendix C - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false C Appendix C Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher Inspection records. Appendix C...

  12. 46 CFR Appendix A - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false A Appendix A Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System Management Information System requirements. Appendix A 46 CFR Ch. I (10-1-10 Edition) Coast Guard, DHS...

  13. 46 CFR Appendix A - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false A Appendix A Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System Management Information System requirements. Appendix A 46 CFR Ch. I (10-1-11 Edition) Coast Guard, DHS...

  14. Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the 2010 result of the LNE-LNHB (France)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Cassette, P.; Moune, M.

    2016-01-01

    Since 2001, six national metrology institutes (NMI) have submitted seven samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.F-18. The values of the activity submitted were between about 1 MBq and 18 MBq. The primary standardization result for the LNE-LNHB, France, replaces their earlier result of 2002 and the key comparison reference value (KCRV) has been recalculated. In the frame of the BIPM.RI(II)-K4.F18 comparison, the NPL updated their result in the KCDB. Consequently there are now five results in the BIPM.RI(II)-K1.F-18 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  15. OM Code Requirements For MOVs -- OMN-1 and Appendix III

    SciTech Connect

    Kevin G. DeWall

    2011-08-01

    The purpose or scope of the ASME OM Code is to establish the requirements for pre-service and in-service testing of nuclear power plant components to assess their operational readiness. For MOVs this includes those that perform a specific function in shutting down a reactor to the safe shutdown condition, maintaining the safe shutdown condition, and mitigating the consequences of an accident. This paper will present a brief history of industry and regulatory activities related to MOVs and the development of Code requirements to address weaknesses in earlier versions of the OM Code. The paper will discuss the MOV requirements contained in the 2009 version of ASME OM Code, specifically Mandatory Appendix III and OMN-1, Revision 1.

  16. 32 CFR Appendix A to Part 881 - Glossary of Terms

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE MILITARY PERSONNEL DETERMINATION OF ACTIVE MILITARY SERVICE AND DISCHARGE FOR CIVILIAN OR CONTRACTUAL GROUPS Pt. 881, App. A Appendix A to Part 881—Glossary of Terms Active Military Service—See 38 U.S.C. 106. Civilian or...

  17. Applying the Model of Goal-Directed Behavior, Including Descriptive Norms, to Physical Activity Intentions: A Contribution to Improving the Theory of Planned Behavior.

    PubMed

    Esposito, Gabriele; van Bavel, René; Baranowski, Tom; Duch-Brown, Néstor

    2016-08-01

    The theory of planned behavior (TPB) has received its fair share of criticism lately, including calls for it to retire. We contribute to improving the theory by testing extensions such as the model of goal-directed behavior (MGDB, which adds desire and anticipated positive and negative emotions) applied to physical activity (PA) intention. We also test the inclusion of a descriptive norms construct as an addition to the subjective norms construct, also applied to PA, resulting in two additional models: TPB including descriptive norms (TPB + DN) and MGDB including descriptive norms (MGDB + DN). The study is based on an online survey of 400 young adult Internet users, previously enrolled in a subject pool. Confirmatory factor analysis (CFA) showed that TPB and TPB + DN were not fit for purpose, while MGDB and MGDB + DN were. Structural equation modelling (SEM) conducted on MGDB and MGDB + DN showed that the inclusion of descriptive norms took over the significance of injunctive norms, and increased the model's account of total variance in intention to be physically active. PMID:27229344

  18. Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus.

    PubMed

    Patel, Kalyani R; Chernock, Rebecca D; Zhang, Tian R; Wang, Xiaowei; El-Mofty, Samir K; Lewis, James S

    2013-11-01

    Most oropharyngeal squamous cell carcinomas (SCC) and histologic variants harbor transcriptionally active human papillomavirus (HPV). While HPV DNA can be found in many non-oropharyngeal head and neck carcinomas, transcriptionally active HPV is rare. Verrucous carcinoma is a variant with bland cytology, warty appearance, locally destructive growth, and lack of metastasis when lacking a frankly invasive carcinoma component. Studies have shown variable rates of HPV DNA and p16 protein expression in such tumors but still have not clearly addressed if the virus has biological activity or clinical relevance in the positive cases. Department files were searched for verrucous neoplasms, including pure verrucous carcinoma, verrucous carcinoma with dysplasia or minimal invasion, and SCC arising in verrucous carcinoma (ie, having a major component of frankly invasive carcinoma). p16 immunohistochemistry, HPV DNA polymerase chain reaction (PCR) and E6/E7 mRNA reverse transcription PCR for high-risk HPV types were performed. Of the 49 cases, 6 (12.2%) showed strong (>50%) staining for p16. HPV DNA was detected in 7/49 (14.3%) cases, but only one case was positive for both p16, and HPV DNA. A total of 36 cases yielded sufficient RNA for RT-PCR (18 verrucous carcinomas, 13 atypical verrucous carcinomas, and 5 SCC arising in verrucous carcinoma). All 36 were negative, including the four p16-positive and three HPV DNA-positive tumors tested. Although a minority of verrucous carcinoma lesions are p16 and HPV DNA positive, transcriptionally active high-risk HPV is uniformly absent. These findings argue that verrucous carcinoma and its related squamous cell carcinomas are not HPV-driven tumors.

  19. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  20. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates

    PubMed Central

    Pfaller, Michael A.; Messer, Shawn A.; Rhomberg, Paul R.; Jones, Ronald N.; Castanheira, Mariana

    2016-01-01

    Objectives The objective of this study was to evaluate the in vitro activity of CD101, a novel echinocandin with a long serum elimination half-life, and comparator (anidulafungin and caspofungin) antifungal agents against a collection of Candida and Aspergillus spp. isolates. Methods CD101 and comparator agents were tested against 106 Candida spp. and 67 Aspergillus spp. isolates, including 27 isolates of Candida harbouring fks hotspot mutations and 12 itraconazole non-WT Aspergillus, using CLSI and EUCAST reference susceptibility broth microdilution (BMD) methods. Results Against WT and fks mutant Candida albicans, Candida glabrata and Candida tropicalis, the activity of CD101 [MIC90 = 0.06, 0.12 and 0.03 mg/L, respectively (CLSI method values)] was comparable to that of anidulafungin (MIC90 = 0.03, 0.12 and 0.03 mg/L, respectively) and caspofungin (MIC90 = 0.12, 0.25 and 0.12 mg/L, respectively). WT Candida krusei isolates were very susceptible to CD101 (MIC = 0.06 mg/L). CD101 activity (MIC50/90 = 1/2 mg/L) was comparable to that of anidulafungin (MIC50/90 = 2/2 mg/L) against Candida parapsilosis. CD101 (MIC mode = 0.06 mg/L for C. glabrata) was 2- to 4-fold more active against fks hotspot mutants than caspofungin (MIC mode = 0.5 mg/L). CD101 was active against Aspergillus fumigatus, Aspergillus terreus, Aspergillus niger and Aspergillus flavus (MEC90 range = ≤0.008–0.03 mg/L). The essential agreement between CLSI and EUCAST methods for CD101 was 92.0%–100.0% among Candida spp. and 95.0%–100.0% among Aspergillus spp. Conclusions The activity of CD101 is comparable to that of other members of the echinocandin class for the prevention and treatment of serious fungal infections. Similar results for CD101 activity versus Candida and Aspergillus spp. may be obtained with either CLSI or EUCAST BMD methods. PMID:27287236

  1. Stages of change for physical activity and dietary habits in persons with type 2 diabetes included in a mobile health intervention: the Norwegian study in RENEWING HEALTH

    PubMed Central

    Holmen, Heidi; Wahl, Astrid; Torbjørnsen, Astrid; Jenum, Anne Karen; Småstuen, Milada Cvancarova; Ribu, Lis

    2016-01-01

    Objective The aim of this study was to investigate stages of change for physical activity and dietary habits using baseline data from persons with type 2 diabetes included in a mobile health intervention. We examined the associations between stages of change for physical activity change and dietary change, and between stages of change for each behavior and individual characteristics, health-related quality of life, self-management, depressive symptoms, and lifestyle. Research design and methods We examined 151 persons with type 2 diabetes with an glycated hemoglobin (HbA1c) level ≥7.1%, aged ≥18 years at baseline of a randomized controlled trial, before testing a mobile app with or without health counseling. Stages of change were dichotomized into ‘pre-action’ and ‘action’. Self-management was measured using the Health Education Impact Questionnaire (heiQ) where a higher score reflects increased self-management, and health-related quality of life was measured with the Short-Form-36 (SF-36). Logistic regression modeling was performed. Results The median HbA1c level was 7.9% (7.1–12.4), 90% were overweight or obese, and 20% had ≥3 comorbidities. 58% were in the preaction stage for physical activity change and 79% in the preaction stage for dietary change. Higher scores of self-management were associated with an increased chance of being in the action stage for both dietary change and physical activity change. Higher body mass index was associated with an 8% reduced chance of being in the action stage for physical activity change (OR 0.92, 95% CI 0.86 to 0.99). Conclusions Being in the action stage was associated with higher scores of self-management, crucial for type 2 diabetes. Over half of the participants were in the preaction stage for physical activity and dietary change, and many had a high disease burden with comorbidities and overweight. Trial registration number NCT01315756. PMID:27239317

  2. A Comparison of Brunt Criteria, the Non Alcoholic Fatty Liver Disease Activity Score (NAS) & a Proposed NAS-including fibrosis as Valid Diagnostic Scores for NASH

    PubMed Central

    Santiago-Rolón, Amarilys; Purcell, Dagmary; Rosado, Kathia; Toro, Doris H.

    2016-01-01

    Objective Non-alcoholic steatohepatitis (NASH) can result in cirrhosis and end stage liver disease. It is of utmost importance to differentiate NASH from simple steatosis. The aim of this study is to determine the prevalence of NASH in Latino veterans with metabolic syndrome and compare histologic grading using Brunt Criteria, the NAFLD activity score (NAS), and a proposed NAS score including fibrosis. Methods Veterans with metabolic syndrome, hepatic steatosis and elevation of ALT/AST who underwent a liver biopsy from 2004-2010 were included in this study. Biopsies were evaluated by a single blinded Hepatopathologist. Steatosis, lobular inflammation, ballooning and fibrosis were graded per specimen. Each biopsy was evaluated using Brunt criteria, NAS and NAS plus fibrosis. Results Sixty patients were included in this study, 88.3% men with a mean age of 50.4 (± 12.8). 50.0% met criteria for NASH according to the Brunt system. When classifying biopsies using NAS, only 30.0% (18/60) had a score ≥5, while when adding fibrosis, the number of patients with a score ≥5 increased to 33 (55.0%). When evaluating the predictive ability of the two scoring systems, we found that NAS including fibrosis had a higher sensitivity than NAS (86.7% vs. 40.0%) and a lower specificity (76.7% vs. 80.0%). Conclusion In our population with metabolic syndrome and altered liver function tests, about 50-55% had steatohepatitis. There were significant differences between the scoring systems. When using NAS-plus-fibrosis more patients were recognized and the sensitivity increased. Further validation studies are required to evaluate this proposed NAS scoring System. PMID:26602577

  3. PREFACE: 9th International Fröhlich's Symposium: Electrodynamic Activity of Living Cells (Including Microtubule Coherent Modes and Cancer Cell Physics)

    NASA Astrophysics Data System (ADS)

    Cifra, Michal; Pokorný, Jirí; Kucera, Ondrej

    2011-12-01

    This volume contains papers presented at the International Fröhlich's Symposium entitled 'Electrodynamic Activity of Living Cells' (1-3 July 2011, Prague, Czech Republic). The Symposium was the 9th meeting devoted to physical processes in living matter organized in Prague since 1987. The hypothesis of oscillation systems in living cells featured by non-linear interaction between elastic and electrical polarization fields, non-linear interactions between the system and the heat bath leading to energy downconversion along the frequency scale, energy condensation in the lowest frequency mode and creation of a coherent state was formulated by H Fröhlich, founder of the theory of dielectric materials. He assumed that biological activity is based not only on biochemical but also on biophysical mechanisms and that their disturbances form basic links along the cancer transformation pathway. Fröhlich outlined general ideas of non-linear physical processes in biological systems. The downconversion and the elastic-polarization interactions should be connected in a unified theory and the solution based on comprehensive non-linear characteristics. Biochemical and genetic research of biological systems are highly developed and have disclosed a variety of cellular and subcellular structures, chemical reactions, molecular information transfer, and genetic code sequences - including their pathological development. Nevertheless, the cancer problem is still a big challenge. Warburg's discovery of suppressed oxidative metabolism in mitochondria in cancer cells suggested the essential role of physical mechanisms (but his discovery has remained without impact on cancer research and on the study of physical properties of biological systems for a long time). Mitochondria, the power plants of the cell, have several areas of activity-oxidative energy production is connected with the formation of a strong static electric field around them, water ordering, and liberation of non

  4. 12 CFR Appendix B to Part 37 - Long Form Disclosures

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... debt suspension agreement If is activated, your duty to pay the loan principal and interest to the bank... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Long Form Disclosures B Appendix B to Part 37 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY DEBT CANCELLATION...

  5. 32 CFR Appendix B to Part 518 - Addressing FOIA Requests

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in 32 CFR part 518 (see appendix A). Contact the DA FOIA/PA Office, to coordinate the referral of requests if there is uncertainty as to which Army activity may have the records. Send requests to particular installations or organizations as follows: (1) Current publications and records of DA...

  6. 32 CFR Appendix B to Part 518 - Addressing FOIA Requests

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CFR part 518 (see appendix A). Contact the DA FOIA/PA Office, to coordinate the referral of requests if there is uncertainty as to which Army activity may have the records. Send requests to particular installations or organizations as follows: (1) Current publications and records of DA field...

  7. 32 CFR Appendix C to Part 651 - Mitigation and Monitoring

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Science: (i) Installation Environmental Specialist. (ii) USACE District Geotechnical Staff. (5) Ecology... (40 CFR 1505.3) if: (1) There is a change in environmental conditions or project activities that were...) ENVIRONMENTAL QUALITY ENVIRONMENTAL ANALYSIS OF ARMY ACTIONS (AR 200-2) Pt. 651, App. C Appendix C to Part...

  8. 18 CFR Appendix A to Subpart H of... - Appendix A to Subpart H of Part 35

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Appendix A to Subpart H of Part 35 A Appendix A to Subpart H of Part 35 Conservation of Power and Water Resources FEDERAL... Rates Pt. 35, Subpt. H, App. A Appendix A to Subpart H of Part 35 Appendix A Standard Screen...

  9. 18 CFR Appendix A to Subpart H of... - Appendix A to Subpart H of Part 35

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Appendix A to Subpart H of Part 35 A Appendix A to Subpart H of Part 35 Conservation of Power and Water Resources FEDERAL... Rates Pt. 35, Subpt. H, App. A Appendix A to Subpart H of Part 35 Appendix A Standard Screen...

  10. 32 CFR Appendix A to Part 47 - Instructions for Submitting Group Applications Under Public Law 95-202

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Instructions for Submitting Group Applications Under Public Law 95-202 A Appendix A to Part 47 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN ACTIVE DUTY SERVICE FOR CIVILIAN OR CONTRACTUAL GROUPS Pt. 47, App. A Appendix A to Part...

  11. Gasoline from coal in the state of Illinois: feasibility study. Appendix 1. Design

    SciTech Connect

    Not Available

    1980-01-01

    Appendix 1 includes the overall design philosophy about units in parallel, specifications above actual need, spares maintenance, etc. Most of the report involves engineering work sheets for various equipments. (LTN)

  12. Hanford environmental analytical methods (methods as of March 1990). Appendix A3-R

    SciTech Connect

    Goheen, S.C.; McCulloch, M.; Daniel, J.L.

    1993-05-01

    Techniques in use at the Hanford Reservation as of March, 1990 for the analysis of liquids and radioactive effluents are described. Limitations and applications of the techniques are included. This report is Appendix A3-R.

  13. 46 CFR Appendix E to Subpart C of... - Respirator Fit Tests

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HEALTH STANDARDS GENERAL PROVISIONS Benzene Pt. 197, Subpt. C, App. E Appendix E to Subpart C of Part 197... employees who may be exposed to benzene and includes the Initial Fit Tests (IFT), the Qualitative Fit...

  14. 46 CFR Appendix E to Subpart C of... - Respirator Fit Tests

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HEALTH STANDARDS GENERAL PROVISIONS Benzene Pt. 197, Subpt. C, App. E Appendix E to Subpart C of Part 197... employees who may be exposed to benzene and includes the Initial Fit Tests (IFT), the Qualitative Fit...

  15. 46 CFR Appendix E to Subpart C to... - Respirator Fit Tests

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH STANDARDS GENERAL PROVISIONS Benzene Pt. 197, Subpt. C, App. E Appendix E to Subpart C to Part 197... employees who may be exposed to benzene and includes the Initial Fit Tests (IFT), the Qualitative Fit...

  16. 32 CFR Appendix E to Part 323 - OMB Guidelines for Matching Programs

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CFR 1-1.337-5). b. The terms of the contract should include appropriate privacy and security... (CONTINUED) PRIVACY PROGRAM DEFENSE LOGISTICS AGENCY PRIVACY PROGRAM Pt. 323, App. E Appendix E to Part...

  17. 33 CFR Appendix B to Part 273 - Information Requirements for Aquatic Plant Control Program Reports

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL Pt. 273, App. B Appendix B to... source of reinfestation; extent of infestation including estimated surface area, depth or density;...

  18. In vitro activity of ceftazidime/avibactam against Gram-negative pathogens isolated from pneumonia in hospitalised patients, including ventilated patients.

    PubMed

    Flamm, Robert K; Nichols, Wright W; Sader, Helio S; Farrell, David J; Jones, Ronald N

    2016-03-01

    The activities of the novel β-lactam/non-β-lactam β-lactamase inhibitor combination ceftazidime/avibactam and comparators were evaluated against isolates from pneumonia in hospitalised patients including ventilated patients (PHP, pneumonia not designated as VABP; VABP, pneumonia in ventilated patients). Isolates were from the European-Mediterranean region (EuM), China and the USA collected in the SENTRY Antimicrobial Surveillance Program between 2009 and 2011 inclusive. A total of 2393 organisms from PHP were from the EuM, 888 from China and 3213 from the USA; from VABP patients there were 918, 97 and 692 organisms collected, respectively. Among Enterobacteriaceae from PHP, ceftazidime/avibactam MIC90 values against Escherichia coli ranged from 0.25-0.5mg/L and Klebsiella spp. MIC90 values were 0.5mg/L in each region. Among VABP isolates, MIC90 values for ceftazidime/avibactam against E. coli were 0.25mg/L; for Klebsiella spp. from VABP patients, MIC90 values were similar to those obtained against PHP isolates. The MIC of ceftazidime/avibactam was ≤8mg/L against 92-96% of Pseudomonas aeruginosa isolated from PHP patients. Isolates of P. aeruginosa from VABP patients were of lower susceptibility to all antibacterial agents (e.g. depending on region, meropenem susceptibilities were 51.2-69.4% in contrast to 68.3-76.7% among PHP patients). However, ceftazidime/avibactam inhibited 79.2-95.4% of VABP isolates at an MIC of ≤8mg/L. Acinetobacter spp. were resistant to many agents and only rates of susceptibility to colistin were >90% across all regions both for PHP and VABP isolates. Ceftazidime/avibactam was generally active against a high proportion of isolates resistant to ceftazidime from PHP and VAPB patients.

  19. Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.

    PubMed

    Kron, Miriam; Howell, C James; Adams, Ian T; Ransbottom, Michael; Christian, Diana; Ogier, Michael; Katz, David M

    2012-10-01

    Excitatory-inhibitory imbalance has been identified within specific brain microcircuits in models of Rett syndrome (RTT) and other autism spectrum disorders (ASDs). However, macrocircuit dysfunction across the RTT brain as a whole has not been defined. To approach this issue, we mapped expression of the activity-dependent, immediate-early gene product Fos in the brains of wild-type (Wt) and methyl-CpG-binding protein 2 (Mecp2)-null (Null) mice, a model of RTT, before and after the appearance of overt symptoms (3 and 6 weeks of age, respectively). At 6 weeks, Null mice exhibit significantly less Fos labeling than Wt in limbic cortices and subcortical structures, including key nodes in the default mode network. In contrast, Null mice exhibit significantly more Fos labeling than Wt in the hindbrain, most notably in cardiorespiratory regions of the nucleus tractus solitarius (nTS). Using nTS as a model, whole-cell recordings demonstrated that increased Fos expression in Nulls at 6 weeks of age is associated with synaptic hyperexcitability, including increased frequency of spontaneous and miniature EPSCs and increased amplitude of evoked EPSCs in Nulls. No such effect of genotype on Fos or synaptic function was seen at 3 weeks. In the mutant forebrain, reduced Fos expression, as well as abnormal sensorimotor function, were reversed by the NMDA receptor antagonist ketamine. In light of recent findings that the default mode network is hypoactive in autism, our data raise the possibility that hypofunction within this meta-circuit is a shared feature of RTT and other ASDs and is reversible. PMID:23035095

  20. 31 CFR Appendix A to Part 356 - Bidder Categories

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... investment decisions of the entity regarding U.S. Treasury securities; • The corporation has written policies... in appendix A to 31 CFR part 356, but for which the purpose of such ownership is to seek a return on... regarding U.S. Treasury securities; • We have written policies or procedures, including ongoing...

  1. 12 CFR Part 745 - SHARE INSURANCE AND APPENDIX

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false SHARE INSURANCE AND APPENDIX 745 PART 745 Banks.... 745.9-2 Retirement and other employee benefit plan accounts. 745.10 Accounts held by government... received by the credit union in its usual course of business, including regular shares, share...

  2. Attentional Processes in Children's Learning. Appendix A: Project Papers.

    ERIC Educational Resources Information Center

    White, Sheldon H.

    This appendix includes seven papers which focus on various aspects of the learning processes of children ages 5-7: (1) S. Thompson, "Transitions to concrete operations: A survey of Piaget's writings" (in outline form); (2) S. H. White, "Changes in learning processes in the late preschool years," an examination of cross-cultural evidence of…

  3. Appendix H - GPRA06 industrial technologies program documentation

    SciTech Connect

    None, None

    2009-01-18

    The information provided in this appendix is based on the Industrial Technologies Program (ITP) report of the GPRA06 process, "GPRA06 Quality Metrics - Methodology and Results," Energetics Inc., October 25, 2004. The report includes additional methodological details and the actual off-line energy savings results submitted to the Office of Energy Efficiency and Renewable Energy (EERE).

  4. 38 CFR Appendix A to Part 200 - Categorical Exclusions

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Appendix A to Part 200 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH... a normally excluded action may have a significant environmental effect. (40 CFR 1508.4) AFRH has... sustainable or “green” procurement) to support operations and infrastructure, including routine...

  5. 38 CFR Appendix A to Part 200 - Categorical Exclusions

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Appendix A to Part 200 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH... a normally excluded action may have a significant environmental effect. (40 CFR 1508.4) AFRH has... sustainable or “green” procurement) to support operations and infrastructure, including routine...

  6. Construction safety program for the National Ignition Facility, Appendix B

    SciTech Connect

    Cerruti, S.J.

    1997-06-26

    This Appendix contains material from the LLNL Health and Safety Manual as listed below. For sections not included in this list, please refer to the Manual itself. The areas covered are: asbestos, lead, fire prevention, lockout, and tag program confined space traffic safety.

  7. Child and Family Resource Program. Appendix to Final Report.

    ERIC Educational Resources Information Center

    Development Associates, Inc., Washington, DC.

    This document presents the appendix to the final report on the Child and Family Resource Program (CFRP), a Head Start-affiliated program designed to promote community and family involvement in fostering optimum development of preschool children. (The final report was contained in a series of documents, which included program descriptions from each…

  8. Catalog of infrared observations. Part 2: Appendixes

    NASA Technical Reports Server (NTRS)

    Gezari, Daniel Y.; Schmitz, Marion; Mead, Jaylee M.

    1987-01-01

    The Catalog of Infrared Observations (CIO) is a compilation of infrared astronomical observational data obtained from an extensive literature search of astronomical journals and major astronomical catalogs and surveys. The literature searches are complete for years 1965 to 1986. Supporting appendixes are published in this part. The appendices include an atlas of infrared source positions, two bibliographies of infrared literature upon which the search was based, and, keyed to the main Catalog listings (organized alphabetically by first author, and by date), an atlas of infrared spectral ranges, and IRAS data for the CIO sources. The complete CIO database is available to qualified users in printed microfiche and magnetic tape formats.

  9. Catalog of infrared observations. Part 2: Appendixes

    NASA Astrophysics Data System (ADS)

    Gezari, Daniel Y.; Schmitz, Marion; Mead, Jaylee M.

    1987-12-01

    The Catalog of Infrared Observations (CIO) is a compilation of infrared astronomical observational data obtained from an extensive literature search of astronomical journals and major astronomical catalogs and surveys. The literature searches are complete for years 1965 to 1986. Supporting appendixes are published in this part. The appendices include an atlas of infrared source positions, two bibliographies of infrared literature upon which the search was based, and, keyed to the main Catalog listings (organized alphabetically by first author, and by date), an atlas of infrared spectral ranges, and IRAS data for the CIO sources. The complete CIO database is available to qualified users in printed microfiche and magnetic tape formats.

  10. 12 CFR Appendix E - Rules for Card Issuers That Bill on a Transaction-by-Transaction Basis

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Transaction-by-Transaction Basis E Appendix E Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF... increases. Pt. 226, App. E Appendix E—Rules for Card Issuers That Bill on a Transaction-by-Transaction Basis.... 9. Section 226.12 including § 226.12(c) and (d), as applicable. Section 226.12(e) is...

  11. 12 CFR Appendix E to Part 334 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 334 Banks... CREDIT REPORTING Part 334, App. E Appendix E to Part 334—Interagency Guidelines Concerning the Accuracy... consumer's account or other relationship, including, for example: (i) Any transfer of an account (e.g.,...

  12. 12 CFR Appendix E to Part 571 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 571 Banks..., App. E Appendix E to Part 571—Interagency Guidelines Concerning the Accuracy and Integrity of...'s account or other relationship, including, for example: (i) Any transfer of an account (e.g.,...

  13. 12 CFR Appendix E to Part 717 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 717 Banks... REPORTING Pt. 717, App. E Appendix E to Part 717—Interagency Guidelines Concerning the Accuracy and...'s account or other relationship, including, for example: (i) Any transfer of an account (e.g.,...

  14. Appendix: Marketing and Student Recruitment Practices for Master's-Level Graduate Programs, 2012. Trends in Enrollment Management

    ERIC Educational Resources Information Center

    Noel-Levitz, Inc, 2012

    2012-01-01

    This paper presents the appendix to "Marketing and Student Recruitment Practices for Master's-Level Graduate Programs, 2012" report. Included in this appendix are: (1) Ratings of the primary practices measured in this study, displayed by institution type; (2) The practice of purchasing prospective student names and addresses; (3) Ratings of…

  15. 23 CFR Appendix C to Subpart A of... - Federal-Aid Highway Contractors Annual EEO Report (Form PR-1391)

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Federal-Aid Highway Contractors Annual EEO Report (Form PR-1391) C Appendix C to Subpart A of Part 230 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Construction Contracts (Including Supportive Services) Pt. 230, Subpt. A, App. C Appendix C to Subpart A...

  16. Taking the Lead in Science Education: Forging Next-Generation Science Standards. International Science Benchmarking Report. Appendix

    ERIC Educational Resources Information Center

    Achieve, Inc., 2010

    2010-01-01

    This appendix accompanies the report "Taking the Lead in Science Education: Forging Next-Generation Science Standards. International Science Benchmarking Report," a study conducted by Achieve to compare the science standards of 10 countries. This appendix includes the following: (1) PISA and TIMSS Assessment Rankings; (2) Courses and Levels…

  17. 23 CFR Appendix C to Subpart A of... - Federal-Aid Highway Contractors Annual EEO Report (Form PR-1391)

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Federal-Aid Highway Contractors Annual EEO Report (Form PR-1391) C Appendix C to Subpart A of Part 230 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF... Construction Contracts (Including Supportive Services) Pt. 230, Subpt. A, App. C Appendix C to Subpart A...

  18. 12 CFR Appendix E to Part 41 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 41 Banks.... E Appendix E to Part 41—Interagency Guidelines Concerning the Accuracy and Integrity of Information... relationship, including, for example: (i) Any transfer of an account (e.g., by sale or assignment...

  19. 12 CFR Appendix E to Part 717 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 717 Banks... REPORTING Pt. 717, App. E Appendix E to Part 717—Interagency Guidelines Concerning the Accuracy and...'s account or other relationship, including, for example: (i) Any transfer of an account (e.g.,...

  20. 12 CFR Appendix E to Part 571 - Interagency Guidelines Concerning the Accuracy and Integrity of Information Furnished to Consumer...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Integrity of Information Furnished to Consumer Reporting Agencies E Appendix E to Part 571 Banks..., App. E Appendix E to Part 571—Interagency Guidelines Concerning the Accuracy and Integrity of...'s account or other relationship, including, for example: (i) Any transfer of an account (e.g.,...

  1. 23 CFR Appendix D to Subpart A of... - Federal-Aid Highway Construction Summary of Employment Data (Form PR-1392)

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (23 U.S.C. sec. 140(a), 315, 49 CFR 1.48(b)) ... Data (Form PR-1392) D Appendix D to Subpart A of Part 230 Highways FEDERAL HIGHWAY ADMINISTRATION... Federal-Aid Construction Contracts (Including Supportive Services) Pt. 230, Subpt. A, App. D Appendix D...

  2. 23 CFR Appendix D to Subpart A of... - Federal-Aid Highway Construction Summary of Employment Data (Form PR-1392)

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (23 U.S.C. sec. 140(a), 315, 49 CFR 1.48(b)) ... Data (Form PR-1392) D Appendix D to Subpart A of Part 230 Highways FEDERAL HIGHWAY ADMINISTRATION... Federal-Aid Construction Contracts (Including Supportive Services) Pt. 230, Subpt. A, App. D Appendix D...

  3. Horseshoe Appendix: An Extremely Rare Appendiceal Anomaly.

    PubMed

    Singh, Ch Gyan; Nyuwi, Kuotho T; Rangaswamy, Raju; Ezung, Yibenthung S; Singh, H Manihar

    2016-03-01

    Appendiceal anomalies are extremely rare malformations that are usually found incidentally. Agenesis and duplication of the appendix has been well documented however, the cases of horseshoe appendix reported is very limited, only four cases reported so far. Here, we report a four and half-year-old who underwent interval appendectomy. Intraoperatively both the ends of the appendix were found to be communicating with the cecum with two separate base or stump located at a sagital disposal- the so called "horseshoe appendix".

  4. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  5. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  6. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  7. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  8. 10 CFR 140.109 - Appendix I.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Appendix I. 140.109 Section 140.109 Energy NUCLEAR... Appendixes to Part 140 § 140.109 Appendix I. Nuclear Energy Liability Insurance Association master policy no. __ Nuclear Energy Liability Insurance (Secondary Financial Protection) Named Insured: Each person...

  9. 34 CFR 303.15 - Include; including.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include; including. 303.15 Section 303.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS...

  10. Kinetics of Hydrogen Radical Reactions with Toluene Including Chemical Activation Theory Employing System-Specific Quantum RRK Theory Calibrated by Variational Transition State Theory.

    PubMed

    Bao, Junwei Lucas; Zheng, Jingjing; Truhlar, Donald G

    2016-03-01

    Pressure-dependent reactions are ubiquitous in combustion and atmospheric chemistry. We employ a new calibration procedure for quantum Rice-Ramsperger-Kassel (QRRK) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff effect of a radical association with an aromatic ring. The new theoretical framework is applied to the reaction of H with toluene, which is a prototypical reaction in the combustion chemistry of aromatic hydrocarbons present in most fuels. Both the hydrogen abstraction reactions and the hydrogen addition reactions are calculated. Our system-specific (SS) QRRK approach is adjusted with SS parameters to agree with multistructural canonical variational transition state theory with multidimensional tunneling (MS-CVT/SCT) at the high-pressure limit. The new method avoids the need for the usual empirical estimations of the QRRK parameters, and it eliminates the need for variational transition state theory calculations as a function of energy, although in this first application we do validate the falloff curves by comparing SS-QRRK results without tunneling to multistructural microcanonical variational transition state theory (MS-μVT) rate constants without tunneling. At low temperatures, the two approaches agree well with each other, but at high temperatures, SS-QRRK tends to overestimate falloff slightly. We also show that the variational effect is important in computing the energy-resolved rate constants. Multiple-structure anharmonicity, torsional-potential anharmonicity, and high-frequency-mode vibrational anharmonicity are all included in the rate computations, and torsional anharmonicity effects on the density of states are investigated. Branching fractions, which are both temperature- and pressure-dependent (and for which only limited data is available from experiment), are predicted as a function of pressure. PMID:26841076

  11. Kinetics of Hydrogen Radical Reactions with Toluene Including Chemical Activation Theory Employing System-Specific Quantum RRK Theory Calibrated by Variational Transition State Theory.

    PubMed

    Bao, Junwei Lucas; Zheng, Jingjing; Truhlar, Donald G

    2016-03-01

    Pressure-dependent reactions are ubiquitous in combustion and atmospheric chemistry. We employ a new calibration procedure for quantum Rice-Ramsperger-Kassel (QRRK) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff effect of a radical association with an aromatic ring. The new theoretical framework is applied to the reaction of H with toluene, which is a prototypical reaction in the combustion chemistry of aromatic hydrocarbons present in most fuels. Both the hydrogen abstraction reactions and the hydrogen addition reactions are calculated. Our system-specific (SS) QRRK approach is adjusted with SS parameters to agree with multistructural canonical variational transition state theory with multidimensional tunneling (MS-CVT/SCT) at the high-pressure limit. The new method avoids the need for the usual empirical estimations of the QRRK parameters, and it eliminates the need for variational transition state theory calculations as a function of energy, although in this first application we do validate the falloff curves by comparing SS-QRRK results without tunneling to multistructural microcanonical variational transition state theory (MS-μVT) rate constants without tunneling. At low temperatures, the two approaches agree well with each other, but at high temperatures, SS-QRRK tends to overestimate falloff slightly. We also show that the variational effect is important in computing the energy-resolved rate constants. Multiple-structure anharmonicity, torsional-potential anharmonicity, and high-frequency-mode vibrational anharmonicity are all included in the rate computations, and torsional anharmonicity effects on the density of states are investigated. Branching fractions, which are both temperature- and pressure-dependent (and for which only limited data is available from experiment), are predicted as a function of pressure.

  12. Waste-Management Education and Research Consortium (WERC) annual progress report, 1991--1992. Appendixes

    SciTech Connect

    Not Available

    1992-04-07

    This report contains the following appendices: Appendix A - Requirements for Undergraduate Level; Appendix B - Requirements for Graduate Level; Appendix C - Graduate Degree In Environmental Engineering; Appendix D - Non-degree Certificate Program; Appendix E - Curriculum for Associate Degree Program; Appendix F - Curriculum for NCC Program; Appendix G - Information 1991 Teleconference Series; Appendix H - Information on 1992 Teleconference Series; Appendix I - WERC interactive Television Courses; Appendix J - WERC Research Seminar Series; Appendix K - Sites for Hazardous/Radioactive Waste Management Series; Appendix L- Summary of Technology Development of the Second Year; Appendix M - List of Major Publications Resulting from WERC; Appendix N - Types of Equipment at WERC Laboratories.

  13. Effects of Lifestyle Interventions That Include a Physical Activity Component in Class II and III Obese Individuals: A Systematic Review and Meta-Analysis

    PubMed Central

    Baillot, Aurélie; Romain, Ahmed J.; Boisvert-Vigneault, Katherine; Audet, Mélisa; Baillargeon, Jean Patrice; Dionne, Isabelle J.; Valiquette, Louis; Chakra, Claire Nour Abou; Avignon, Antoine; Langlois, Marie-France

    2015-01-01

    Background In class II and III obese individuals, lifestyle intervention is the first step to achieve weight loss and treat obesity-related comorbidities before considering bariatric surgery. A systematic review, meta-analysis, and meta-regression were performed to assess the impact of lifestyle interventions incorporating a physical activity (PA) component on health outcomes of class II and III obese individuals. Methods An electronic search was conducted in 4 databases (Medline, Scopus, CINAHL and Sportdiscus). Two independent investigators selected original studies assessing the impact of lifestyle interventions with PA components on anthropometric parameters, cardiometabolic risk factors (fat mass, blood pressure, lipid and glucose metabolism), behaviour modification (PA and nutritional changes), and quality of life in adults with body mass index (BMI) ≥ 35 kg/m2. Estimates were pooled using a random-effect model (DerSimonian and Laird method). Heterogeneity between studies was assessed by the Cochran’s chi-square test and quantified through an estimation of the I². Results Of the 3,170 identified articles, 56 met our eligibility criteria, with a large majority of uncontrolled studies (80%). The meta-analysis based on uncontrolled studies showed significant heterogeneity among all included studies. The pooled mean difference in weight loss was 8.9 kg (95% CI, 10.2–7.7; p < 0.01) and 2.8 kg/m² in BMI loss (95% CI, 3.4–2.2; p < 0.01). Long-term interventions produced superior weight loss (11.3 kg) compared to short-term (7.2 kg) and intermediate-term (8.0 kg) interventions. A significant global effect of lifestyle intervention on fat mass, waist circumference, blood pressure, total cholesterol, LDL-C, triglycerides and fasting insulin was found (p<0.01), without significant effect on HDL-C and fasting blood glucose. Conclusions Lifestyle interventions incorporating a PA component can improve weight and various cardiometabolic risk factors in class II

  14. Seed dormancy breaking diterpenoids, including novel brassicicenes J and K, from fungus Alternaria brassicicola, and their necrotic/apoptotic activities in HL-60 cells.

    PubMed

    Kenmoku, Hiromichi; Takeue, Sayaka; Oogushi, Megumi; Yagi, Yasuyuki; Sassa, Takeshi; Toyota, Masao; Asakawa, Yoshinori

    2014-03-01

    To find new metabolites similar to cotylenins and fusicoccins from the fungus Alternaria brassicicola, screening tests were carried out using the lettuce seed dormancy breaking assay. Activity-guided fractionation of the EtOAc extract from the culture using the assay afforded the isolation of two novel fusicoccane diterpenoids named brassicicenes J (1) and K (2), along with three known brassicicenes A (3), B (4), and F (5). Their structures were elucidated from extensive NMR spectral data and by comparison of these with those reported in the literature. Brassicicenes (1-5) exhibited weak to moderate seed dormancy breaking activities against lettuce seeds in the presence of abscisic acid. In addition, the necrotic/apoptotic activities of the brassicicenes (1-5), fusicoccin A (6) and cotylenin A (7) were evaluated by determining their cytotoxicity, cell viability and caspase-3/7 activation on the HL-60 cell line. Brassicicene K (2) exhibited similar cytostatic profiles to that of cotylenin A (7), and brassicicenes J (1), A (3), B (4), and F (5) exhibited necrotic activity. This is the first report of the seed dormancy breaking activity of brassicicenes in plants, and of necrotic/apoptotic activity in mammalian cells. PMID:24689212

  15. Streptococcus milleri in the appendix.

    PubMed Central

    Poole, P M; Wilson, G

    1977-01-01

    The appendix was investigated as a possible habitat of Streptococcus milleri. Both normal and inflamed appendices were examined and the isolation rates compared. S. milleri was present in a quarter of the normal appendices and more than half of those associated with apendicitis--a difference that was statistically highly significant. The isolation rates throughout were indepencent of age. There was a pronounced connection between the presence of S. milleri in the appendix and the purulent manifestations of appendicitis. S. milleri was isolated from other abdominal sites associated with appendicitis. The frequency of isolation was increased by culture in an enrichment broth containing nalidixic acid and sulphadimidine. PMID:591633

  16. Streptococcus milleri in the appendix.

    PubMed

    Poole, P M; Wilson, G

    1977-10-01

    The appendix was investigated as a possible habitat of Streptococcus milleri. Both normal and inflamed appendices were examined and the isolation rates compared. S. milleri was present in a quarter of the normal appendices and more than half of those associated with apendicitis--a difference that was statistically highly significant. The isolation rates throughout were indepencent of age. There was a pronounced connection between the presence of S. milleri in the appendix and the purulent manifestations of appendicitis. S. milleri was isolated from other abdominal sites associated with appendicitis. The frequency of isolation was increased by culture in an enrichment broth containing nalidixic acid and sulphadimidine.

  17. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Appendix E. Final report

    SciTech Connect

    1988-07-01

    This document provides Appendix E of the Remedial Action Plan (RAP) presented in 1988 for the stabilization of the inactive uranium mill tailings at the Mexican Hat, Utah site. The RAP was developed to serve a two- fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by the DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. The RAP has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action.

  18. Validation of the Japanese version of the Systemic Lupus Activity Questionnaire that includes physician-based assessments in a large observational cohort.

    PubMed

    Okamoto, Y; Katsumata, Y; Baba, S; Kawaguchi, Y; Gono, T; Hanaoka, M; Kawasumi, H; Yamanaka, H

    2016-04-01

    The Systemic Lupus Activity Questionnaire (SLAQ) is a patient-reported outcome for systemic lupus erythematosus (SLE). We aimed to translate it into Japanese and further investigate its validity and reliability. The English version of the SLAQ was translated into Japanese and administered to Japanese SLE patients at our university clinic. Physicians assessed disease activity using the SLE Disease Activity Index 2000 (SLEDAI-2K). The patients were prospectively followed for repeat assessment a year later. Ultimately, 255 patients participated. The patients' 10-point ratings of disease activity and SLAQ scores were significantly correlated (Spearman's ρ = 0.53). The SLAQ score was weakly correlated with the SLE Disease Activity Index 2000 (SLEDAI-2K)-nolab (omitting laboratory items; ρ = 0.18) but not with the SLEDAI-2K (ρ = 0.02). These results suggested its convergent and discriminant validity. The SLAQ demonstrated acceptable internal consistency (Cronbach's α = 0.80), and good test-retest reliability (intraclass correlation coefficient = 0.85). The effect sizes and the standardized response means of the SLAQ were as follows: clinical worsening, 0.26 and 0.31, and improvement, -0.39 and -0.41, respectively, which indicated a small but significant responsiveness. The Japanese version of the SLAQ demonstrated acceptable reliability and validity; its performance was comparable to that of the original version.

  19. 23 CFR Appendix G to Subpart A of... - Special Reporting Requirements for “Hometown” or “Imposed” Plan Areas

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... to 23 CFR part 230) and in accordance with the instructions included thereon. ...Imposedâ Plan Areas G Appendix G to Subpart A of Part 230 Highways FEDERAL HIGHWAY ADMINISTRATION... Federal-Aid Construction Contracts (Including Supportive Services) Pt. 230, Subpt. A, App. G Appendix G...

  20. Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4.

    PubMed

    Slack, R J; Hall, D A

    2012-07-01

    BACKGROUND AND PURPOSE The operational model provides a key conceptual framework for the analysis of pharmacological data. However, this model does not include constitutive receptor activity, a frequent phenomenon in modern pharmacology, particularly in recombinant systems. Here, we developed extensions of the operational model which include constitutive activity and applied them to effects of agonists at the chemokine receptor CCR4. EXPERIMENTAL APPROACH The effects of agonists of CCR4 on [(35) S]GTPγS binding to recombinant cell membranes and on the filamentous (F-) actin content of human CD4(+) CCR4(+) T cells were determined. The basal [(35) S]GTPγS binding was changed by varying the GDP concentration whilst the basal F-actin contents of the higher expressing T cell populations were elevated, suggesting constitutive activity of CCR4. Both sets of data were analysed using the mathematical models. RESULTS The affinity of CCL17 (also known as TARC) derived from analysis of the T cell data (pK(a) = 9.61 ± 0.17) was consistent with radioligand binding experiments (9.50 ± 0.11) while that from the [(35) S]GTPγS binding experiments was lower (8.27 ± 0.09). Its intrinsic efficacy differed between the two systems (110 in T cells vs. 11). CONCLUSIONS AND IMPLICATIONS The presence of constitutive receptor activity allows the absolute intrinsic efficacy of agonists to be determined without a contribution from the signal transduction system. Intrinsic efficacy estimated in this way is consistent with Furchgott's definition of this property. CCL17 may have a higher intrinsic efficacy at CCR4 in human T cells than that expressed recombinantly in CHO cells.

  1. On the recent seismic activity in North-Eastern Aegean Sea including the Mw5.8 earthquake on 8 January 2013

    PubMed Central

    SARLIS, Nicholas V.

    2013-01-01

    In the last week of November 2012, we announced that a strong electrotelluric disturbance, which we judged to be a Seismic Electric Signal (SES) activity, was recorded at station Assiros located in Northern Greece. This disturbance was actually followed by an Mw5.8 earthquake on 8 January 2013 in North-Eastern Aegean Sea. Here we show that, by analyzing this SES activity and employing the natural time analysis of subsequent seismicity, we estimated the epicentral location, magnitude and occurrence time which are reasonably compatible with those of the Mw5.8 event. PMID:24213207

  2. Preliminary Safety Information Document for the Standard MHTGR. Volume 1, (includes latest Amendments)

    SciTech Connect

    1986-12-01

    With NRC concurrence, the Licensing Plan for the Standard HTGR describes an application program consistent with 10CFR50, Appendix O to support a US Nuclear Regulatory Commission (NRC) review and design certification of an advanced Standard modular High Temperature Gas-Cooled Reactor (MHTGR) design. Consistent with the NRC's Advanced Reactor Policy, the Plan also outlines a series of preapplication activities which have as an objective the early issuance of an NRC Licensability Statement on the Standard MHTGR conceptual design. This Preliminary Safety Information Document (PSID) has been prepared as one of the submittals to the NRC by the US Department of Energy in support of preapplication activities on the Standard MHTGR. Other submittals to be provided include a Probabilistic Risk Assessment, a Regulatory Technology Development Plan, and an Emergency Planning Bases Report.

  3. FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles

    PubMed Central

    Pendergrast, P. Shannon; Wang, Chen; Hernandez, Nouria; Huang, Sui

    2002-01-01

    FBI-1 is a cellular POZ-domain–containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically stimulate Tat activity and that this effect is dependent on the same domain of FBI-1 that mediates Tat-FBI-1 association in vivo. FBI-1 also partially colocalizes with Tat and Tat's cellular cofactor, P-TEFb (Cdk9 and cyclin T1), at the splicing-factor–rich nuclear speckle domain. Further, a less-soluble population of FBI-1 distributes in a novel peripheral-speckle pattern of localization as well as in other nuclear regions. This distribution pattern is dependent on the FBI-1 DNA binding domain, on the presence of cellular DNA, and on active transcription. Taken together, these results suggest that FBI-1 is a cellular factor that preferentially associates with active chromatin and that can specifically stimulate Tat-activated HIV-1 transcription. PMID:11907272

  4. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.

    PubMed

    Pendergrast, P Shannon; Wang, Chen; Hernandez, Nouria; Huang, Sui

    2002-03-01

    FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically stimulate Tat activity and that this effect is dependent on the same domain of FBI-1 that mediates Tat-FBI-1 association in vivo. FBI-1 also partially colocalizes with Tat and Tat's cellular cofactor, P-TEFb (Cdk9 and cyclin T1), at the splicing-factor-rich nuclear speckle domain. Further, a less-soluble population of FBI-1 distributes in a novel peripheral-speckle pattern of localization as well as in other nuclear regions. This distribution pattern is dependent on the FBI-1 DNA binding domain, on the presence of cellular DNA, and on active transcription. Taken together, these results suggest that FBI-1 is a cellular factor that preferentially associates with active chromatin and that can specifically stimulate Tat-activated HIV-1 transcription.

  5. Stirling Space Engine Program. Volume 2; Appendixes A, B, C and D

    NASA Technical Reports Server (NTRS)

    Dhar, Manmohan

    1999-01-01

    The objective of this program was to develop the technology necessary for operating Stirling power converters in a space environment and to demonstrate this technology in full-scale engine tests. Volume 2 of the report includes the following appendices: Appendix A: Heater Head Development (Starfish Heater Head Program, 1/10th Segment and Full-Scale Heat Pipes, and Sodium Filling and Processing); Appendix B: Component Test Power Converter (CTPC) Component Development (High-temperature Organic Materials, Heat Exchanger Fabrication, Beryllium Issues, Sodium Issues, Wear Couple Tests, Pressure Boundary Penetrations, Heating System Heaters, and Cooler Flow Test); Appendix C: Udimet Testing (Selection of the Reference Material for the Space Stirling Engine Heater Head, Udimet 720LI Creep Test Result Update, Final Summary of Space Stirling Endurance Engine Udimet 720L1 Fatigue Testing Results, Udimet 720l1 Weld Development Summary, and Udimet 720L1 Creep Test Final Results Summary), and Appendix D: CTPC Component Development Photos.

  6. Applying the model of Goal-Directed Behavior, including descriptive norms, to physical activity intentions: A contribution to improving the Theory of Planned Behavior

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The theory of planned behavior (TPB) has received its fair share of criticism lately, including calls for it to retire. We contributed to improving the theory by testing extensions such as the model of goal-directed behavior (MGDB, which adds desire and anticipated positive and negative emotions) ap...

  7. 49 CFR Appendix - Editorial Note:

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 16084; 28 CFR § 0.66). The Assistant Attorney General, Land and Natural Resources Division, has further.... Editorial Note: For Federal Register citations affecting appendix A to part 1, see the List of CFR Sections... determinations as to the sufficiency of titles. The Chief Counsels of the Federal Aviation...

  8. EspC, an Autotransporter Protein Secreted by Enteropathogenic Escherichia coli, Causes Apoptosis and Necrosis through Caspase and Calpain Activation, Including Direct Procaspase-3 Cleavage

    PubMed Central

    Serapio-Palacios, Antonio

    2016-01-01

    ABSTRACT Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors during infection are poorly understood. EspC produced by EPEC cleaves fodrin, paxillin, and focal adhesion kinase (FAK), which are also cleaved by caspases and calpains during apoptosis. Here we show the role of EspC in cell death induced by EPEC. EspC is involved in EPEC-mediated cell death and induces both apoptosis and necrosis in epithelial cells. EspC induces apoptosis through the mitochondrial apoptotic pathway by provoking (i) a decrease in the expression levels of antiapoptotic protein Bcl-2, (ii) translocation of the proapoptotic protein Bax from cytosol to mitochondria, (iii) cytochrome c release from mitochondria to the cytoplasm, (iv) loss of mitochondrial membrane potential, (v) caspase-9 activation, (vi) cleavage of procaspase-3 and (vii) an increase in caspase-3 activity, (viii) PARP proteolysis, and (ix) nuclear fragmentation and an increase in the sub-G1 population. Interestingly, EspC-induced apoptosis was triggered through a dual mechanism involving both independent and dependent functions of its EspC serine protease motif, the direct cleavage of procaspase-3 being dependent on this motif. This is the first report showing a shortcut for induction of apoptosis by the catalytic activity of an EPEC protein. Furthermore, this atypical intrinsic apoptosis appeared to induce necrosis through the activation of calpain and through the increase of intracellular calcium induced by EspC. Our data indicate that EspC plays a relevant role in cell death induced by EPEC. PMID:27329750

  9. Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs draft environmental impact statement. Volume 1, Appendix B: Idaho National Engineering Laboratory Spent Nuclear Fuel Management Program

    SciTech Connect

    Not Available

    1994-06-01

    The US Department of Energy (DOE) has prepared this report to assist its management in making two decisions. The first decision, which is programmatic, is to determine the management program for DOE spent nuclear fuel. The second decision is on the future direction of environmental restoration, waste management, and spent nuclear fuel management activities at the Idaho National Engineering Laboratory. Volume 1 of the EIS, which supports the programmatic decision, considers the effects of spent nuclear fuel management on the quality of the human and natural environment for planning years 1995 through 2035. DOE has derived the information and analysis results in Volume 1 from several site-specific appendixes. Volume 2 of the EIS, which supports the INEL-specific decision, describes environmental impacts for various environmental restoration, waste management, and spent nuclear fuel management alternatives for planning years 1995 through 2005. This Appendix B to Volume 1 considers the impacts on the INEL environment of the implementation of various DOE-wide spent nuclear fuel management alternatives. The Naval Nuclear Propulsion Program, which is a joint Navy/DOE program, is responsible for spent naval nuclear fuel examination at the INEL. For this appendix, naval fuel that has been examined at the Naval Reactors Facility and turned over to DOE for storage is termed naval-type fuel. This appendix evaluates the management of DOE spent nuclear fuel including naval-type fuel.

  10. Isolation of estrogen-degrading bacteria from an activated sludge bioreactor treating swine waste, including a strain that converts estrone to β-estradiol.

    PubMed

    Isabelle, Martine; Villemur, Richard; Juteau, Pierre; Lépine, François

    2011-07-01

    An estrogen-degrading bacterial consortium from a swine wastewater biotreatment was enriched in the presence of low concentrations (1 mg/L) of estrone (E1), 17β-estradiol (βE2), and equol (EQO) as sole carbon sources. The consortium removed 99% ± 1% of these three estrogens in 48 h. Estrogen removal occurred even in the presence of an ammonia monooxygenase inhibitor, suggesting that nitrifiers are not involved. Five strains showing estrogen-metabolizing activity were isolated from the consortium on mineral agar medium with estrogens as sole carbon source. They are related to four genera ( Methylobacterium (strain MI6.1R), Ochrobactrum (strains MI6.1B and MI9.3), Pseudomonas (strain MI14.1), and Mycobacterium (strain MI21.2)) distributed among three classes (Alphaproteobacteria, Gammaproteobacteria, and Actinobacteria). Depending on the culture medium, strains MI6.1B, MI9.3, MI14.1, and MI21.2 partially transform βE2 into E1, whereas Methylobacterium sp. strain MI6.1R reduces E1 into βE2 under aerobic conditions, in contrast with the usually observed conversion of βE2 into E1. Since βE2 is a more potent endocrine disruptor than E1, it means that the presence of Methylobacterium sp. strain MI6.1R (or other bacteria with the same E1-reducing activity) in a treatment could transiently increase the estrogenicity of the effluent. MI6.1R can also reduce the ketone group of 16-ketoestradiol, a hydroxylated analog of E1. All βE2 and E1 transformation activities were constitutive, and many of them are favoured in a rich medium than a medium containing no other carbon source. None of the isolated strains could degrade EQO. PMID:21770814

  11. Evaluation of automated decisionmaking methodologies and development of an integrated robotic system simulation, appendix A

    NASA Technical Reports Server (NTRS)

    Haley, D. C.; Almand, B. J.; Thomas, M. M.; Krauze, L. D.; Gremban, K. D.; Sanborn, J. C.; Kelly, J. H.; Depkovich, T. M.

    1984-01-01

    A generic computer simulation for manipulator systems (ROBSIM) was implemented and the specific technologies necessary to increase the role of automation in various missions were developed. The specific items developed were: (1) Capability for definition of a manipulator system consisting of multiple arms, load objects, and an environment; (2) Capability for kinematic analysis, requirements analysis, and response simulation of manipulator motion; (3) Postprocessing options such as graphic replay of simulated motion and manipulator parameter plotting; (4) Investigation and simulation of various control methods including manual force/torque and active compliance control; (5) Evaluation and implementation of three obstacle avoidance methods; (6) Video simulation and edge detection; and (7) Software simulation validation. This appendix is the user's guide and includes examples of program runs and outputs as well as instructions for program use.

  12. 13 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 113

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Appendix A to Subpart A of Part 113 A Appendix A to Subpart A of Part 113 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... ADMINISTRATOR General Provisions Pt. 113, Subpt. A, App. A Appendix A to Subpart A of Part 113 Name of...

  13. 13 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 113

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Appendix A to Subpart A of Part 113 A Appendix A to Subpart A of Part 113 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... ADMINISTRATOR General Provisions Pt. 113, Subpart A, App. A Appendix A to Subpart A of Part 113 Name of...

  14. 13 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 113

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Appendix A to Subpart A of Part 113 A Appendix A to Subpart A of Part 113 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... ADMINISTRATOR General Provisions Pt. 113, Subpart A, App. A Appendix A to Subpart A of Part 113 Name of...

  15. 13 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 113

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Appendix A to Subpart A of Part 113 A Appendix A to Subpart A of Part 113 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... ADMINISTRATOR General Provisions Pt. 113, Subpt. A, App. A Appendix A to Subpart A of Part 113 Name of...

  16. 36 CFR Appendix A to Part 14 - Appendix A to Part 14

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Appendix A to Part 14 A Appendix A to Part 14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR RIGHTS-OF-WAY Pt. 14, App. A Appendix A to Part 14 Where necessary, these forms should be modified so...

  17. 42 CFR Appendix A to Subpart C of... - Appendix A to Subpart C of Part 1001

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Appendix A to Subpart C of Part 1001 A Appendix A... Permissive Exclusions Pt. 1001, Subpt. C, App. A Appendix A to Subpart C of Part 1001 The following is a... for restocked drugs or supplies for which a participating ambulance provider bills or is eligible...

  18. 45 CFR Appendix A to Part 611 - Appendix A to Part 611

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Appendix A to Part 611 A Appendix A to Part 611 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... CIVIL RIGHTS ACT OF 1964 Pt. 611, App. A Appendix A to Part 611 Statutory Provisions under which...

  19. 49 CFR Appendix A to Part 5 - Appendix A to Part 5

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Appendix A to Part 5 A Appendix A to Part 5 Transportation Office of the Secretary of Transportation RULEMAKING PROCEDURES Pt. 5, App. A Appendix A to Part 5 Pursuant to § 5.1(b), the following officials of the Office of the Secretary of Transportation...

  20. 14 CFR Appendix B to Part 25 - Appendix B to Part 25

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Appendix B to Part 25 B Appendix B to Part 25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Pt. 25, App. B Appendix B to Part 25 EC28SE91.055...

  1. 24 CFR Appendix B to 24 Cfr Part 3400 - Appendix B to 24 CFR Part 3400

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix B to 24 CFR Part 3400 B Appendix B to 24 CFR Part 3400 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT SAFE MORTGAGE LICENSING ACT Pt. 3400, App. B Appendix B to 24 CFR Part...

  2. 24 CFR Appendix D to 24 Cfr Part 3400 - Appendix D to 24 CFR Part 3400

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix D to 24 CFR Part 3400 D Appendix D to 24 CFR Part 3400 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT SAFE MORTGAGE LICENSING ACT Pt. 3400, App. D Appendix D to 24 CFR Part...

  3. 12 CFR Appendix Ms-1 to Part 1024 - Appendix MS-1 to Part 1024

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Appendix MS-1 to Part 1024 MS Appendix MS-1 to Part 1024 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION REAL ESTATE SETTLEMENT PROCEDURES ACT (REGULATION X) Pt. 1024, App. MS-1 Appendix MS-1 to Part 1024 SERVICING DISCLOSURE...

  4. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  5. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  6. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  7. 12 CFR Appendix Ms-3 to Part 1024 - Appendix MS-3 to Part 1024

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Appendix MS-3 to Part 1024 MS Appendix MS-3 to... ACT (REGULATION X) Pt. 1024, App. MS-3 Appendix MS-3 to Part 1024 Model Force-Placed Insurance Notice Forms Table of Contents MS-3(A)—Model Form for Force-Placed Insurance Notice Containing...

  8. 24 CFR Appendix C to 24 Cfr Part 3400 - Appendix C to 24 CFR Part 3400

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix C to 24 CFR Part 3400 C Appendix C to 24 CFR Part 3400 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT SAFE MORTGAGE LICENSING ACT Pt. 3400, App. C Appendix C to 24 CFR Part...

  9. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  10. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  11. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  12. 30 CFR Appendix A to Subpart J of... - Appendix A to Subpart J of Part 75

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Appendix A to Subpart J of Part 75 A Appendix A to Subpart J of Part 75 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Medium-Voltage Alternating Current Circuits Pt. 75, Subpt. J, App. A Appendix A to Subpart J of Part...

  13. 14 CFR Appendix G to Part 151 - Appendix G to Part 151

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Appendix G to Part 151 G Appendix G to Part 151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Pt. 151, App. G Appendix G to Part 151 There is set forth below...

  14. 30 CFR Appendix A to Subpart J of... - Appendix A to Subpart J of Part 75

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Appendix A to Subpart J of Part 75 A Appendix A to Subpart J of Part 75 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Medium-Voltage Alternating Current Circuits Pt. 75, Subpt. J, App. A Appendix A to Subpart J of Part...

  15. 30 CFR Appendix A to Subpart J of... - Appendix A to Subpart J of Part 75

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Appendix A to Subpart J of Part 75 A Appendix A to Subpart J of Part 75 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Medium-Voltage Alternating Current Circuits Pt. 75, Subpt. J, App. A Appendix A to Subpart J of Part...

  16. 30 CFR Appendix A to Subpart J of... - Appendix A to Subpart J of Part 75

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Appendix A to Subpart J of Part 75 A Appendix A to Subpart J of Part 75 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Medium-Voltage Alternating Current Circuits Pt. 75, Subpt. J, App. A Appendix A to Subpart J of Part...

  17. 30 CFR Appendix A to Subpart J of... - Appendix A to Subpart J of Part 75

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Appendix A to Subpart J of Part 75 A Appendix A to Subpart J of Part 75 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Medium-Voltage Alternating Current Circuits Pt. 75, Subpt. J, App. A Appendix A to Subpart J of Part...

  18. 14 CFR Appendix E to Part 151 - Appendix E to Part 151

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Appendix E to Part 151 E Appendix E to Part 151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Pt. 151, App. E Appendix E to Part 151 There is set forth below...

  19. 14 CFR Appendix F to Part 151 - Appendix F to Part 151

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Appendix F to Part 151 F Appendix F to Part 151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Pt. 151, App. F Appendix F to Part 151 There is set forth below...

  20. 14 CFR Appendix F to Part 151 - Appendix F to Part 151

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Appendix F to Part 151 F Appendix F to Part 151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Pt. 151, App. F Appendix F to Part 151 There is set forth below...

  1. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  2. 24 CFR Appendix Ms-1 to Part 3500 - Appendix MS-1 to Part 3500

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Appendix MS-1 to Part 3500 MS Appendix MS-1 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-1 Appendix MS-1...

  3. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  4. 24 CFR Appendix Ms-2 to Part 3500 - Appendix MS-2 to Part 3500

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Appendix MS-2 to Part 3500 MS Appendix MS-2 to Part 3500 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT REAL ESTATE SETTLEMENT PROCEDURES ACT Pt. 3500, App. MS-2 Appendix MS-2...

  5. 24 CFR Appendix D to 24 Cfr Part 3400 - Appendix D to 24 CFR Part 3400

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Appendix D to 24 CFR Part 3400 D Appendix D to 24 CFR Part 3400 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT SAFE MORTGAGE LICENSING ACT Pt. 3400, App. D Appendix D to 24 CFR Part...

  6. 24 CFR Appendix A to 24 Cfr Part 3400 - Appendix A to 24 CFR Part 3400

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Appendix A to 24 CFR Part 3400 A Appendix A to 24 CFR Part 3400 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT SAFE MORTGAGE LICENSING ACT Pt. 3400, App. A Appendix A to 24 CFR Part...

  7. 24 CFR Appendix A to 24 Cfr Part 3400 - Appendix A to 24 CFR Part 3400

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Appendix A to 24 CFR Part 3400 A Appendix A to 24 CFR Part 3400 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT SAFE MORTGAGE LICENSING ACT Pt. 3400, App. A Appendix A to 24 CFR Part...

  8. 14 CFR Appendix F to Part 151 - Appendix F to Part 151

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Appendix F to Part 151 F Appendix F to Part 151 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS FEDERAL AID TO AIRPORTS Pt. 151, App. F Appendix F to Part 151 There is set forth below...

  9. Flow cytometric analysis of the Rh1 (Rho, D) antigen activity on red cells: various Rh blood group phenotypes including Du variants.

    PubMed

    Ota, M; Hasekura, H; Fukushima, H; Yonemura, I

    1989-04-01

    Rh1 (Rho, D) antigen activity has been analyzed by the use of the indirect immunofluorescence flow cytometry (FCM), and the Rh blood group genotypes were able to be successfully determined from the intensity of fluorescence detected in flow cytometry using the anti-D IgG that was fractionated in a Protein A Sepharose CL-4B column as the primary antibody. The relative amount of the fluorescein isothiocyanate (FITC) bound to the D (R1R1, CDe/CDe), the high grade Du (R2r',cDE/Cde), the low grade Du (K1r, CDue/cde), and the d (rr, cde/cde) red cells was estimated from the mean fluorescent intensity. The FITC-binding activity of the high grade Du and low grade Du was 83% and 21% that of D. The antigen-antibody complex density profile was analyzed by using the FITC-conjugated protein-A in place of the second antibody. Compared with the found results using anti-human globulin as the second antibody, this method was less sensitive but it still was able to demonstrate the different degrees of fluorescence according to the Rh genotypes. The present FCM method is both simple and useful for (1) measuring the relative amount of antigens, (2) for detecting the dosage effect and (3) for deferminins the blood group genotypes.

  10. Fumigant toxicity of Oriental sweetgum (Liquidambar orientalis) and valerian (Valeriana wallichii) essential oils and their components, including their acetylcholinesterase inhibitory activity, against Japanese termites (Reticulitermes speratus).

    PubMed

    Park, Il-Kwon

    2014-01-01

    This study investigated the fumigant toxicity of oriental sweetgum (Liquidambar orientalis) and valerian (Valeriana wallichii) essential oils and their components against the Japanese termite (Reticulitermes speratus). The fumigant toxicity of oriental sweetgum and valerian oil differed significantly according to exposure time. Oriental sweetgum showed toxicity at short exposure times (2 days), and the toxicity of valerian oil was high 7 days after treatment. The main constituents of oriental sweetgum and valerian oils were tested individually for their fumigant toxicity against Japanese termites. Among the test compounds, benzyl alcohol, acetophenone, 1-phenyl-1-ethanol, hydrocinnamyl alcohol, trans-cinnamyl aldehyde, trans-cinnamyl alcohol, cis-asarone, styrene, and cis-ocimene showed toxicity against Japanese termites 7 days after treatment. Hydrocinnamyl alcohol and trans-cinnamyl alcohol were found to be the major contributors to the fumigant antitermitic toxicity of oriental sweetgum oil. The acetylcholinesterase (AChE) inhibition activity of two oils and their constituents was tested to determine their mode of action. Only cis-ocimene showed strong AChE inhibition activity with an IC50 value of 0.131 mg/mL. Further studies are warranted to determine the potential of these essential oils and their constituents as fumigants for termite control. PMID:25153870

  11. Fumigant toxicity of Oriental sweetgum (Liquidambar orientalis) and valerian (Valeriana wallichii) essential oils and their components, including their acetylcholinesterase inhibitory activity, against Japanese termites (Reticulitermes speratus).

    PubMed

    Park, Il-Kwon

    2014-08-19

    This study investigated the fumigant toxicity of oriental sweetgum (Liquidambar orientalis) and valerian (Valeriana wallichii) essential oils and their components against the Japanese termite (Reticulitermes speratus). The fumigant toxicity of oriental sweetgum and valerian oil differed significantly according to exposure time. Oriental sweetgum showed toxicity at short exposure times (2 days), and the toxicity of valerian oil was high 7 days after treatment. The main constituents of oriental sweetgum and valerian oils were tested individually for their fumigant toxicity against Japanese termites. Among the test compounds, benzyl alcohol, acetophenone, 1-phenyl-1-ethanol, hydrocinnamyl alcohol, trans-cinnamyl aldehyde, trans-cinnamyl alcohol, cis-asarone, styrene, and cis-ocimene showed toxicity against Japanese termites 7 days after treatment. Hydrocinnamyl alcohol and trans-cinnamyl alcohol were found to be the major contributors to the fumigant antitermitic toxicity of oriental sweetgum oil. The acetylcholinesterase (AChE) inhibition activity of two oils and their constituents was tested to determine their mode of action. Only cis-ocimene showed strong AChE inhibition activity with an IC50 value of 0.131 mg/mL. Further studies are warranted to determine the potential of these essential oils and their constituents as fumigants for termite control.

  12. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans.

    PubMed Central

    Kniazeva, Marina; Sieber, Matt; McCauley, Scott; Zhang, Kang; Watts, Jennifer L; Han, Min

    2003-01-01

    While the general steps of fatty acid (FA) biosynthesis are well understood, the individual enzymes involved in the elongation of long chain saturated and polyunsaturated FA (PUFA) are largely unknown. Recent research indicates that these enzymes might be of considerable physiological importance for human health. We use Caenorhabditis elegans to study FA elongation activities and associated abnormal phenotypes. In this article we report that the predicted C. elegans F11E6.5/ELO-2 is a functional enzyme with the FA elongation activity. It is responsible for the elongation of palmitic acid and is involved in PUFA biosynthesis. RNAi-mediated suppression of ELO-2 causes an accumulation of palmitate and an associated decrease in the PUFA fraction in triacylglycerides and phospholipid classes. This imbalance in the FA composition results in multiple phenotypic defects such as slow growth, small body size, reproductive defects, and changes in rhythmic behavior. ELO-2 cooperates with the previously reported ELO-1 in 20-carbon PUFA production, and at least one of the enzymes must function to provide normal growth and development in C. elegans. The presented data indicate that suppression of a single enzyme of the FA elongation machinery is enough to affect various organs and systems in worms. This effect resembles syndromic disorders in humans. PMID:12586704

  13. Pig skin includes dendritic cell subsets transcriptomically related to human CD1a and CD14 dendritic cells presenting different migrating behaviors and T cell activation capacities.

    PubMed

    Marquet, Florian; Vu Manh, Thien-Phong; Maisonnasse, Pauline; Elhmouzi-Younes, Jamila; Urien, Céline; Bouguyon, Edwige; Jouneau, Luc; Bourge, Mickael; Simon, Gaëlle; Ezquerra, Angel; Lecardonnel, Jérôme; Bonneau, Michel; Dalod, Marc; Schwartz-Cornil, Isabelle; Bertho, Nicolas

    2014-12-15

    Swine skin is one of the best structural models for human skin, widely used to probe drug transcutaneous passage and to test new skin vaccination devices. However, little is known about its composition in immune cells, and among them dendritic cells (DC), that are essential in the initiation of the immune response. After a first seminal work describing four different DC subpopulations in pig skin, we hereafter deepen the characterization of these cells, showing the similarities between swine DC subsets and their human counterparts. Using comparative transcriptomic study, classical phenotyping as well as in vivo and in vitro functional studies, we show that swine CD163(pos) dermal DC (DDC) are transcriptomically similar to the human CD14(pos) DDC. CD163(pos) DDC are recruited in inflamed skin, they migrate in inflamed lymph but they are not attracted toward CCL21, and they modestly activate allogeneic CD8 T cells. We also show that CD163(low) DDC are transcriptomically similar to the human CD1a(pos) DDC. CD163(low) DDC migrate toward CCL21, they activate allogeneic CD8 and CD4 T cells and, like their potential human lung counterpart, they skew CD4 T cells toward a Th17 profile. We thus conclude that swine skin is a relevant model for human skin vaccination.

  14. Flow cytometric analysis of the Rh1 (Rho, D) antigen activity on red cells: various Rh blood group phenotypes including Du variants.

    PubMed

    Ota, M; Hasekura, H; Fukushima, H; Yonemura, I

    1989-04-01

    Rh1 (Rho, D) antigen activity has been analyzed by the use of the indirect immunofluorescence flow cytometry (FCM), and the Rh blood group genotypes were able to be successfully determined from the intensity of fluorescence detected in flow cytometry using the anti-D IgG that was fractionated in a Protein A Sepharose CL-4B column as the primary antibody. The relative amount of the fluorescein isothiocyanate (FITC) bound to the D (R1R1, CDe/CDe), the high grade Du (R2r',cDE/Cde), the low grade Du (K1r, CDue/cde), and the d (rr, cde/cde) red cells was estimated from the mean fluorescent intensity. The FITC-binding activity of the high grade Du and low grade Du was 83% and 21% that of D. The antigen-antibody complex density profile was analyzed by using the FITC-conjugated protein-A in place of the second antibody. Compared with the found results using anti-human globulin as the second antibody, this method was less sensitive but it still was able to demonstrate the different degrees of fluorescence according to the Rh genotypes. The present FCM method is both simple and useful for (1) measuring the relative amount of antigens, (2) for detecting the dosage effect and (3) for deferminins the blood group genotypes. PMID:2509769

  15. Heterogeneity in Pseudomonas aeruginosa Biofilms Includes Expression of Ribosome Hibernation Factors in the Antibiotic-Tolerant Subpopulation and Hypoxia-Induced Stress Response in the Metabolically Active Population

    PubMed Central

    Williamson, Kerry S.; Richards, Lee A.; Perez-Osorio, Ailyn C.; Pitts, Betsey; McInnerney, Kathleen; Stewart, Philip S.

    2012-01-01

    Bacteria growing in biofilms are physiologically heterogeneous, due in part to their adaptation to local environmental conditions. Here, we characterized the local transcriptome responses of Pseudomonas aeruginosa growing in biofilms by using a microarray analysis of isolated biofilm subpopulations. The results demonstrated that cells at the top of the biofilms had high mRNA abundances for genes involved in general metabolic functions, while mRNA levels for these housekeeping genes were low in cells at the bottom of the biofilms. Selective green fluorescent protein (GFP) labeling showed that cells at the top of the biofilm were actively dividing. However, the dividing cells had high mRNA levels for genes regulated by the hypoxia-induced regulator Anr. Slow-growing cells deep in the biofilms had little expression of Anr-regulated genes and may have experienced long-term anoxia. Transcripts for ribosomal proteins were associated primarily with the metabolically active cell fraction, while ribosomal RNAs were abundant throughout the biofilms, indicating that ribosomes are stably maintained even in slowly growing cells. Consistent with these results was the identification of mRNAs for ribosome hibernation factors (the rmf and PA4463 genes) at the bottom of the biofilms. The dormant biofilm cells of a P. aeruginosa Δrmf strain had decreased membrane integrity, as shown by propidium iodide staining. Using selective GFP labeling and cell sorting, we show that the dividing cells are more susceptible to killing by tobramycin and ciprofloxacin. The results demonstrate that in thick P. aeruginosa biofilms, cells are physiologically distinct spatially, with cells deep in the biofilm in a viable but antibiotic-tolerant slow-growth state. PMID:22343293

  16. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells

    SciTech Connect

    Gao Jiayu; Morgan, Winston A.; Sanchez-Medina, Alberto; Corcoran, Olivia

    2011-08-01

    Despite a lack of scientific authentication, Scutellaria baicalensis is clinically used in Chinese medicine as a traditional adjuvant to chemotherapy of lung cancer. In this study, cytotoxicity assays demonstrated that crude ethanolic extracts of S. baicalensis were selectively toxic to human lung cancer cell lines A549, SK-LU-1 and SK-MES-1 compared with normal human lung fibroblasts. The active compounds baicalin, baicalein and wogonin did not exhibit such selectivity. Following exposure to the crude extracts, cellular protein expression in the cancer cell lines was assessed using 2D gel electrophoresis coupled with MALDI-TOF-MS/Protein Fingerprinting. The altered protein expression indicated that cell growth arrest and apoptosis were potential mechanisms of cytotoxicity. These observations were supported by PI staining cell cycle analysis using flow cytometry and Annexin-V apoptotic analysis by fluorescence microscopy of cancer cells treated with the crude extract and pure active compounds. Moreover, specific immunoblotting identification showed the decreased expression of cyclin A results in the S phase arrest of A549 whereas the G{sub 0}/G{sub 1} phase arrest in SK-MES-1 cells results from the decreased expression of cyclin D1. Following treatment, increased expression in the cancer cells of key proteins related to the enhancement of apoptosis was observed for p53 and Bax. These results provide further insight into the molecular mechanisms underlying the clinical use of this herb as an adjuvant to lung cancer therapy. - Research Highlights: > Scutellaria baicalensis is a clinical adjuvant to lung cancer chemotherapy in China. > Scutellaria ethanol extracts selectively toxic to A549, SK-LU-1 and SK-MES-1. > Baicalin, baicalein and wogonin were toxic to all lung cancer cell lines. > Proteomics identified increased p53 and BAX in response to Scutellaria extracts.

  17. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  18. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  19. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  20. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C Appendix C to Subpart G of Part 42—Department Regulations Under Title VI of the Civil Rights......

  1. 28 CFR Appendix C to Subpart G of... - Department Regulations Under Title VI of the Civil Rights Act of 1964 (28 CFR 42.106-42.110...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Civil Rights Act of 1964 (28 CFR 42.106-42.110) Which Apply to This Subpart C Appendix C to... CFR 42.106-42.110) Which Apply to This Subpart Editorial Note: For the text of appendix C, see §§ 42... Activities-Implementation of Section 504 of the Rehabilitation Act of 1973 Pt. 42, Subpt. G, App. C...

  2. MifM Monitors Total YidC Activities of Bacillus subtilis, Including That of YidC2, the Target of Regulation

    PubMed Central

    Ito, Koreaki

    2014-01-01

    The YidC/Oxa1/Alb3 family proteins are involved in membrane protein biogenesis in bacteria, mitochondria, and chloroplasts. Recent studies show that YidC uses a channel-independent mechanism to insert a class of membrane proteins into the membrane. Bacillus subtilis has two YidC homologs, SpoIIIJ (YidC1) and YidC2 (YqjG); the former is expressed constitutively, while the latter is induced when the SpoIIIJ activity is compromised. MifM is a substrate of SpoIIIJ, and its failure in membrane insertion is accompanied by stable ribosome stalling on the mifM-yidC2 mRNA, which ultimately facilitates yidC2 translation. While mutational inactivation of SpoIIIJ has been known to induce yidC2 expression, here, we show that the level of this induction is lower than that observed when the membrane insertion signal of MifM is defective. Moreover, this partial induction of YidC2 translation is lowered further when YidC2 is overexpressed in trans. These results suggest that YidC2 is able to insert MifM into the membrane and to release its translation arrest. Thus, under SpoIIIJ-deficient conditions, YidC2 expression is subject to MifM-mediated autogenous feedback repression. Our results show that YidC2 uses a mechanism that is virtually identical to that used by SpoIIIJ; Arg75 of YidC2 in its intramembrane yet hydrophilic cavity is functionally indispensable and requires negatively charged residues of MifM as an insertion substrate. From these results, we conclude that MifM monitors the total activities of the SpoIIIJ and the YidC2 pathways to control the synthesis of YidC2 and to maintain the cellular capability of the YidC mode of membrane protein biogenesis. PMID:25313395

  3. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.

    PubMed

    Niederwieser, D; Baldomero, H; Szer, J; Gratwohl, M; Aljurf, M; Atsuta, Y; Bouzas, L F; Confer, D; Greinix, H; Horowitz, M; Iida, M; Lipton, J; Mohty, M; Novitzky, N; Nunez, J; Passweg, J; Pasquini, M C; Kodera, Y; Apperley, J; Seber, A; Gratwohl, A

    2016-06-01

    Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation. PMID:26901703

  4. Building Astronomy Curriculum to Include the Sight Impaired: Week long summer camp activities for Middle School Students adherent to Washington State Curriculum Standards (EALR's)

    NASA Astrophysics Data System (ADS)

    Ramien, Natalie; Loebman, S. R.; Player, V.; Larson, A.; Torcolini, N. B.; Traverse, A.

    2011-01-01

    Currently astronomy learning is heavily geared towards visual aids; however, roughly 10 million people in North America are sight impaired. Every student should have access to meaningful astronomy curriculum; an understanding of astronomy is an expectation of national and state science learning requirements. Over the last ten years, Noreen Grice has developed Braille and large print astronomy text books aimed at sight impaired learners. We build upon Grice's written work and present here a five day lesson plan that integrates 2D reading with 3D activities. Through this curriculum, students develop an intuitive understanding of astronomical distance, size, composition and lifetimes. We present five distinct lesson modules that can be taught individually or in a sequential form: the planets, our sun, stars, stellar evolution and galaxies. We have tested these modules on sight impaired students and report the results here. Overall, we find the work presented here lends itself equally well to a week long science camp geared toward middle school sight impaired taught by astronomers or as supplemental material integrated into a regular classroom science curriculum. This work was made possible by a 2007 Simple Effective Education and Dissemination (SEED) Grant For Astronomy Researchers, Astronomical Society of the Pacific through funds provided by the Planck Mission, Jet Propulsion Laboratory, California Institute of Technology.

  5. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.

    PubMed

    Niederwieser, D; Baldomero, H; Szer, J; Gratwohl, M; Aljurf, M; Atsuta, Y; Bouzas, L F; Confer, D; Greinix, H; Horowitz, M; Iida, M; Lipton, J; Mohty, M; Novitzky, N; Nunez, J; Passweg, J; Pasquini, M C; Kodera, Y; Apperley, J; Seber, A; Gratwohl, A

    2016-06-01

    Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation.

  6. Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex.

    PubMed

    Sui, Dexin; Xu, Xinjing; Ye, Xuemei; Liu, Mengyu; Mianecki, Maxwell; Rattanasinchai, Chotirat; Buehl, Christopher; Deng, Xiexiong; Kuo, Min-Hao

    2015-01-01

    Many biomedically critical proteins are underrepresented in proteomics and biochemical studies because of the difficulty of their production in Escherichia coli. These proteins might possess posttranslational modifications vital to their functions, tend to misfold and be partitioned into bacterial inclusion bodies, or act only in a stoichiometric dimeric complex. Successful production of these proteins requires efficient interaction between these proteins and a specific "facilitator," such as a protein-modifying enzyme, a molecular chaperone, or a natural physical partner within the dimeric complex. Here we report the design and application of a protein interaction module-assisted function X (PIMAX) system that effectively overcomes these hurdles. By fusing two proteins of interest to a pair of well-studied protein-protein interaction modules, we were able to potentiate the association of these two proteins, resulting in successful production of an enzymatically active cyclin-dependent kinase complex and hyperphosphorylated tau protein, which is intimately linked to Alzheimer disease. Furthermore, using tau isoforms quantitatively phosphorylated by GSK-3β and CDK5 kinases via PIMAX, we demonstrated the hyperphosphorylation-stimulated tau oligomerization in vitro, paving the way for new Alzheimer disease drug discoveries. Vectors for PIMAX can be easily modified to meet the needs of different applications. This approach thus provides a convenient and modular suite with broad implications for proteomics and biomedical research.

  7. Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.

    PubMed

    Liu, Ang; Lute, John; Gu, Huidong; Wang, Bonnie; Trouba, Kevin J; Arnold, Mark E; Aubry, Anne-Françoise; Wang, Jian

    2015-09-01

    BMS-986094, a nucleotide polymerase inhibitor of the hepatitis C virus, was withdrawn from clinical trials because of a serious safety issue. To investigate a potential association between drug/metabolite exposure and toxicity in evaluations conducted after the termination of the BMS-986094 development program, it was essential to determine the levels of BMS-986094 and its major metabolites INX-08032, INX-08144 and INX-09054 in circulation and the active nucleoside triphosphate INX-09114 in target and non-target tissues. However, there were many challenges in the bioanalysis of these compounds. The chromatography challenge for the extremely polar nucleoside triphosphate was solved by applying mixed-mode chromatography which combined anion exchange and reversed-phase interactions. The LC conditions provided adequate retention and good peak shape of the analyte and showed good robustness. A strategy using simultaneous extraction but separate LC analysis of the prodrug BMS-986094 and its major circulating metabolites was used to overcome a carryover issue of the hydrophobic prodrug while still achieving good chromatography of the polar metabolites. In addition, the nucleotide analytes were not stable in the presence of endogenous enzymes. Low pH and low temperature were required for blood collection and plasma sample processing. However, the use of phosphatase inhibitor and immediate homogenization and extraction were critical for the quantitative analysis of the active triphosphate, INX-09114, in tissue samples. To alleviate the bioanalytical complexity caused by multiple analytes, different matrices, and various species, a fit-for-purpose approach to assay validation was implemented based on the needs of drug safety assessment in non-clinical (GLP or non-GLP) studies. The assay for INX-08032 was fully validated in plasma of toxicology species. The lower limit of quantification was 1.00ng/mL and the linear curve range was 1.00-500.00ng/mL using a weighted (1/x(2

  8. Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.

    PubMed

    Liu, Ang; Lute, John; Gu, Huidong; Wang, Bonnie; Trouba, Kevin J; Arnold, Mark E; Aubry, Anne-Françoise; Wang, Jian

    2015-09-01

    BMS-986094, a nucleotide polymerase inhibitor of the hepatitis C virus, was withdrawn from clinical trials because of a serious safety issue. To investigate a potential association between drug/metabolite exposure and toxicity in evaluations conducted after the termination of the BMS-986094 development program, it was essential to determine the levels of BMS-986094 and its major metabolites INX-08032, INX-08144 and INX-09054 in circulation and the active nucleoside triphosphate INX-09114 in target and non-target tissues. However, there were many challenges in the bioanalysis of these compounds. The chromatography challenge for the extremely polar nucleoside triphosphate was solved by applying mixed-mode chromatography which combined anion exchange and reversed-phase interactions. The LC conditions provided adequate retention and good peak shape of the analyte and showed good robustness. A strategy using simultaneous extraction but separate LC analysis of the prodrug BMS-986094 and its major circulating metabolites was used to overcome a carryover issue of the hydrophobic prodrug while still achieving good chromatography of the polar metabolites. In addition, the nucleotide analytes were not stable in the presence of endogenous enzymes. Low pH and low temperature were required for blood collection and plasma sample processing. However, the use of phosphatase inhibitor and immediate homogenization and extraction were critical for the quantitative analysis of the active triphosphate, INX-09114, in tissue samples. To alleviate the bioanalytical complexity caused by multiple analytes, different matrices, and various species, a fit-for-purpose approach to assay validation was implemented based on the needs of drug safety assessment in non-clinical (GLP or non-GLP) studies. The assay for INX-08032 was fully validated in plasma of toxicology species. The lower limit of quantification was 1.00ng/mL and the linear curve range was 1.00-500.00ng/mL using a weighted (1/x(2

  9. Aryl hydrocarbon receptor SNP -130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24.

    PubMed

    Liu, Ge; Asanoma, Kazuo; Takao, Tomoka; Tsukimori, Kiyomi; Uchi, Hiroshi; Furue, Masutaka; Kato, Kiyoko; Wake, Norio

    2015-01-22

    Dioxins are persistent environmental pollutants that cause multiple adverse health effects in humans, mainly through binding to the ligand-activated transcription factor, aryl hydrocarbon receptor (AhR). Genetic variation in AhR may modulate the susceptibility to dioxins. In this study, we aimed to evaluate the effects of the single nucleotide polymorphism (SNP) -130 C/T in the AhR promoter on dioxin-inducible gene transcription, and to investigate interleukin-24 (IL-24) and interleukin-1β (IL-1β) as proxies for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Using primary human chorionic stromal cells, we found that cells with the TT genotype showed higher AhR mRNA and protein levels than did those of the CC genotype. Microarray was carried out to analyze the gene expression profiles of cells (CC and TT genotype) after exposing the cells to TCDD. Several genes associated with human disorders were more highly up-regulated in cells of the TT genotype. Higher up-regulation of IL-24 and IL-1β mRNA in cells with the TT genotype was observed. Furthermore, blood samples from 64 Yusho patients who were accidentally exposed to high concentrations of dioxins were analyzed for the genotype, dioxins concentrations and serum levels of IL-24 and IL-1β. We observed higher serum IL-24 levels and lower serum IL-1β levels in Yusho patients with the TT genotype than in those with the CC genotype. AhR SNP -130 C/T affects serum IL-24 and IL-1β levels, independently of serum dioxins concentrations in Yusho patients. Our observations demonstrate that SNP -130 C/T modulates AhR expression and expression levels of IL-24 and IL-1β, and suggest an association of AhR SNP -130 C/T with the susceptibility to dioxins.

  10. Real time programming environment for Windows, Appendix A

    SciTech Connect

    1998-04-05

    This appendix contains all source code for the RTProE system. The following file contents are included: pdb.h; hgen.l; hgen.y; igen.l; igen.y; pdm.l; pdm.y; rtdata.l; rtdata.y; framegen.c; librt.c; librt.h; rtsched.c; build.tsh; sde.tcl; rtsched.def.

  11. MM&T: Bibliography on optical testing with appendix

    NASA Astrophysics Data System (ADS)

    Cornejo-Rodriguez, A.; Caulfield, H. J.; Friday, W.

    1982-02-01

    The following is a major expansion of 'Bibliography on Various Optical Testing Methods,' by Daniel Malacara, Alejandro Cornejo, and M. V. R. K. Murty which appeared in Applied Optica, 14, 1065 - 1080(1975). It is computerized to allow for easy update and correction. The last update was in September 1979. For availability information, please contact either of the authors. The present bibliography occupies 321 pages and includes the work of Cornejo, et al. as an appendix.

  12. Quantitative and Qualitative Effects of Revised Selection and Training Procedures in the Education of Teachers of the Culturally Disadvantaged. Volume III. Final Report. Appendixes E-R.

    ERIC Educational Resources Information Center

    Bothner, Gerald; And Others

    Appendix E is a proposal for a biological science course for prospective elementary teachers. The major topics covered are 1) the perpetuation of life; 2) the maintenance of life; 3) living things in action; 4) living things in relationship to their environment. A weekly course schedule is also included. Appendix F is a proposal for preservice…

  13. 40 CFR Appendix J to Subpart G of... - Substitutes listed in the January 29, 2002 Final Rule, effective April 1, 2002

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., 4, 5. Additional comments: 1—Should conform to relevant OSHA requirements, including 29 CFR 1910..., 2002 Final Rule, effective April 1, 2002 J Appendix J to Subpart G of Part 82 Protection of Environment... Significant New Alternatives Policy Program Pt. 82, Subpt. G, App. J Appendix J to Subpart G of Part...

  14. Final report from VFL Technologies for the pilot-scale thermal treatment of Lower East Fork Poplar Creek floodplain soils. LEFPC appendices. Volume 5. Appendix V-D

    SciTech Connect

    1994-09-01

    This final report from VFL Technologies for the pilot-scale thermal treatment of lower East Fork Poplar Creek floodplain soils dated September 1994 contains LEFPC Appendices, Volume 5, Appendix V - D. This appendix includes the final verification run data package (PAH, TCLP herbicides, TCLP pesticides).

  15. 40 CFR Appendix J to Subpart G of... - Substitutes listed in the January 29, 2002 Final Rule, effective April 1, 2002

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., 4, 5. Additional comments: 1—Should conform to relevant OSHA requirements, including 29 CFR 1910..., 2002 Final Rule, effective April 1, 2002 J Appendix J to Subpart G of Part 82 Protection of Environment... Significant New Alternatives Policy Program Pt. 82, Subpt. G, App. J Appendix J to Subpart G of Part...

  16. 40 CFR Appendix Xii to Part 86 - Tables for Production Compliance Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles, Including Light-Duty Trucks XII Appendix XII to...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Pt. 86, App. XII Appendix XII to Part 86—Tables for Production Compliance Auditing of Heavy-Duty Engines and Heavy-Duty...

  17. 40 CFR Appendix Xii to Part 86 - Tables for Production Compliance Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles, Including Light-Duty Trucks XII Appendix XII to...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Pt. 86, App. XII Appendix XII to Part 86—Tables for Production Compliance Auditing of Heavy-Duty Engines and...

  18. 40 CFR Appendix Xii to Part 86 - Tables for Production Compliance Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles, Including Light-Duty Trucks XII Appendix XII to...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Pt. 86, App. XII Appendix XII to Part 86—Tables for Production Compliance Auditing of Heavy-Duty Engines and...

  19. 40 CFR Appendix Xii to Part 86 - Tables for Production Compliance Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles, Including Light-Duty Trucks XII Appendix XII to...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Pt. 86, App. XII Appendix XII to Part 86—Tables for Production Compliance Auditing of Heavy-Duty Engines and...

  20. 40 CFR Appendix Xii to Part 86 - Tables for Production Compliance Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Auditing of Heavy-Duty Engines and Heavy-Duty Vehicles, Including Light-Duty Trucks XII Appendix XII to...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) Pt. 86, App. XII Appendix XII to Part 86—Tables for Production Compliance Auditing of Heavy-Duty Engines and...

  1. Benthic food web structure in the Comau fjord, Chile (∼42°S): Preliminary assessment including a site with chemosynthetic activity

    NASA Astrophysics Data System (ADS)

    Zapata-Hernández, Germán; Sellanes, Javier; Mayr, Christoph; Muñoz, Práxedes

    2014-12-01

    Using C and N stable isotopes we analyzed different trophic aspects of the benthic fauna at two sites in the Comau fjord: one with presence of venting of chemically reducing fluids and extensive patches of bacterial mats (XH: X-Huinay), and one control site (PG: Punta Gruesa) with a typical fjord benthic habitat. Due to the widespread presence of such microbial patches in the fjord and their recognized trophic role in reducing environments, we hypothesize that these microbial communities could be contributing to the assimilated food of consumers and transferring carbon into high trophic levels in the food web. Food sources in the area included macroalgae with a wide range of δ13C values (-34.7 to -11.9‰), particulate organic matter (POM, δ13C = -20.1‰), terrestrial organic matter (TOM, δ13C = -32.3‰ to -27.9‰) and chemosynthetic filamentous bacteria (δ13C = ∼-33‰). At both sites, fauna depicted typical values indicating photosynthetic production as a main food source (>-20‰). However, at XH selected taxa reported lower δ13C values (e.g. -26.5‰ in Nacella deaurata), suggesting a partial use of chemosynthetic production. Furthermore, enhanced variability at this site in δ13C values of the polyplacophoran Chiton magnificus, the limpet Fissurella picta and the tanaid Zeuxoides sp. may also be responding to the use of a wider scope of primary food sources. Trophic position estimates suggest three trophic levels of consumers at both sites. However, low δ15N values in some grazer and suspension-feeder species suggest that these taxa could be using other sources still to be identified (e.g. bacterial films, microalgae and organic particles of small size-fractions). Furthermore, between-site comparisons of isotopic niche width measurements in some trophic guilds indicate that grazers from XH have more heterogenic trophic niches than at PG (measured as mean distance to centroid and standard deviation of nearest neighbor distance). This last could be

  2. Uranium hydrogeochemical and stream sediment reconnaissance data release for the Elk City NTMS Quadrangle, Idaho/Montana, including concentrations of forty-five additional elements

    SciTech Connect

    Broxton, D.E.; Beyth, M.

    1980-07-01

    Totals of 1580 water and 1720 sediment samples were collected from 1754 locations in the quadrangle. Elemental concentration, field measurement, weather, geologic, and geographic data for each sample location are listed for waters in Appendix I-A and for sediments in Appendix I-B. Uranium/thorium ratios for sediment samples are also included in Appendix I-B. All elemental analyses were performed at the LASL. Water samples were initially analyzed for uranium by fluorometry. All water samples containing more than 40 parts per billion (ppB) uranium were reanalyzed by delayed-neutron counting (DNC). A supplemental report containing the multielement analyses of water samples will be open filed in the near future. Sediments were analyzed for uranium and thorium as well as aluminum, antimony, arsenic, barium, beryllium, bismuth, cadmium, calcium, cerium, cesium, chlorine, chromium, cobalt, copper, dysprosium, europium, gold, hafnium, iron, lanthanum, lead, lithium, lutetium, magnesium, manganese, nickel, niobium, potassium, rubidium, samarium, selenium, scandium, silver, sodium, strontium, tantalum, terbium, tin, titanium, tungsten, vanadium, ytterbium, zinc, and zirconium. Basic statistics for 40 of these elements are presented. All sediments were analyzed for uranium by delayed-neutron counting. Other elemental concentrations in sediments were determined by neutron-activation analysis for 30 elements, by x-ray fluorescence for 12 elements, and by arc-source emission spectrography for 2 elements. Analytical results for sediments are reported as parts per million.

  3. Comparing bottom-up and top-down approaches at the landscape scale, including agricultural activities and water systems, at the Roskilde Fjord, Denmark

    NASA Astrophysics Data System (ADS)

    Lequy, Emeline; Ibrom, Andreas; Ambus, Per; Massad, Raia-Silvia; Markager, Stiig; Asmala, Eero; Garnier, Josette; Gabrielle, Benoit; Loubet, Benjamin

    2015-04-01

    The greenhouse gas nitrous oxide (N2O) mainly originates in direct emissions from agricultural soils due to microbial reactions stimulated by the use of nitrogen fertilisers. Indirect N2O emissions from water systems due to nitrogen leaching and deposition from crop fields range between 26 and 37% of direct agricultural emissions, indicating their potential importance and uncertainty (Reay et al. 2012). The study presented here couples a top-down approach with eddy covariance (EC) and a bottom-up approach using different models and measurements. A QCL sensor at 96-m height on a tall tower measures the emissions of N2O from 1100 ha of crop fields and from the south part of the Roskilde fjord, in a 5-km radius area around the tall tower at Roskilde, Denmark. The bottom-up approach includes ecosystem modelling with CERES-EGC for the crops and PaSIM for the grasslands, and the N2O fluxes from the Roskilde fjord are derived from N2O sea water concentration measurements. EC measurements are now available from July to December 2014, and indicate a magnitude of the emissions from the crop fields around 0.2 mg N2O-N m-2 day-1 (range -9 to 5) which is consistent with the CERES-EGC simulations and calculations using IPCC emission factors. N2O fluxes from the Roskilde fjord in May and July indicated quite constant N2O concentrations around 0.1 µg N L-1 despite variations of nitrate and ammonium in the fjord. The calculated fluxes from these concentrations and the tall tower measurements consistently ranged between -7 and 6 mg N2O-N m-2 day-1. The study site also contains a waste water treatment plant, whose direct emissions will be measured in early 2015 using a dynamic plume tracer dispersion method (Mønster et al. 2014). A refined source attribution methodology together with more measurements and simulations of the N2O fluxes from the different land uses in this study site will provide a clearer view of the dynamics and budgets of N2O at the regional scale. The

  4. Pump apparatus including deconsolidator

    SciTech Connect

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  5. Trigonometry, Including Snell's Theorem.

    ERIC Educational Resources Information Center

    Kent, David

    1980-01-01

    Aspects of the instruction of trigonometry in secondary school mathematics are reviewed. Portions of this document cover basic introductions, a student-developed theorem, the cosine rule, inverse functions, and a sample outdoor activity. (MP)

  6. 41 CFR Appendix to Subchapter G... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Appendix to Subchapter G-Temporary Regulations Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES Appendix...

  7. 41 CFR Appendix to Subchapter G... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Appendix to Subchapter G-Temporary Regulations Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES Appendix...

  8. 41 CFR Appendix to Subchapter E... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Appendix to Subchapter E-Temporary Regulations Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT Appendix to Subchapter...

  9. 31 CFR Appendixes to Chapter V - Note

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Note Appendixes to Chapter V Money... CONTROL, DEPARTMENT OF THE TREASURY Ch. V, Nt. Appendixes to Chapter V—Note Notes: The alphabetical lists... blocked vessel in the underlying transaction. See § 501.604(b)(1) of this chapter. Financial...

  10. 43 CFR 10010.31 - Appendix.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Environmental Impact Statements § 10010.31 Appendix. If an EIS is intended to serve other environmental review or consultation requirements pursuant to 40 CFR 1502.25, any more detailed information needed to... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Appendix. 10010.31 Section 10010.31...

  11. Absence of the appendix discovered during childhood.

    PubMed

    Vincent, Michelle V; Doyle, Alex; Bernstein, Sean; Jackman, Selma

    2014-01-01

    Absence of the appendix is rare. Isolated cases are usually discovered in adult patients or cadavers. We report the case of a 14 year old boy who was found to have no appendix on laparotomy for assumed acute appendicitis and use this opportunity to highlight the growing surgical uses of this vestigial structure.

  12. 41 CFR Appendix to Subchapter H... - Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (FMR) (41 CFR chapter 102, parts 102-1 through 102-220). Appendix to Subchapter H—Temporary Regulations ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Reserved to Appendix to Subchapter H-Temporary Regulations Public Contracts and Property Management Federal Property...

  13. 41 CFR Appendix to Subchapter H... - Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (FMR) (41 CFR chapter 102, parts 102-1 through 102-220). Appendix to Subchapter H—Temporary Regulations ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Reserved to Appendix to Subchapter H-Temporary Regulations Public Contracts and Property Management Federal Property...

  14. Appendix D-16A Building 515 Waste Accumulation Area

    SciTech Connect

    Tidwell, L

    2005-03-29

    The B-515 WAA is located in the southeast quadrant of the LLNL Main Site (see Figure D-1) along the west side of Building 515 (B-515). Hazardous wastes may be stored at the B-515 WAA for 90 days or less, until transferred to the appropriate Radioactive and Hazardous Waste Management (RHWM) facility or other permitted treatment, storage or disposal facility (TSDF). The design storage capacity of this WAA is 4,840 gallons. This appendix is designed to provide information specific to the Building 515 Waste Accumulation Area (B-515 WAA), a waste storage area. This appendix is not designed to be used as a sole source of information. All general information that is not specific to the B-515 WAA is included in the Contingency Plan for Waste Accumulation Areas, dated July 2004, and should be referenced.

  15. 29 CFR 471.2 - What employee notice clause must be included in Government contracts?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... included in Government contracts? (a) Government contracts. With respect to all contracts covered by this part, Government contracting departments and agencies must, to the extent consistent with law, include the language set forth in appendix A to subpart A of part 471 in every Government contract, other...

  16. 29 CFR 471.2 - What employee notice clause must be included in Government contracts?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... included in Government contracts? (a) Government contracts. With respect to all contracts covered by this part, Government contracting departments and agencies must, to the extent consistent with law, include the language set forth in appendix A to subpart A of part 471 in every Government contract, other...

  17. 29 CFR 471.2 - What employee notice clause must be included in Government contracts?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... included in Government contracts? (a) Government contracts. With respect to all contracts covered by this part, Government contracting departments and agencies must, to the extent consistent with law, include the language set forth in appendix A to subpart A of part 471 in every Government contract, other...

  18. 29 CFR 471.2 - What employee notice clause must be included in Government contracts?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... included in Government contracts? (a) Government contracts. With respect to all contracts covered by this part, Government contracting departments and agencies must, to the extent consistent with law, include the language set forth in appendix A to subpart A of part 471 in every Government contract, other...

  19. 29 CFR 471.2 - What employee notice clause must be included in Government contracts?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... included in Government contracts? (a) Government contracts. With respect to all contracts covered by this part, Government contracting departments and agencies must, to the extent consistent with law, include the language set forth in appendix A to subpart A of part 471 in every Government contract, other...

  20. Listening to Include

    ERIC Educational Resources Information Center

    Veck, Wayne

    2009-01-01

    This paper attempts to make important connections between listening and inclusive education and the refusal to listen and exclusion. Two lines of argument are advanced. First, if educators and learners are to include each other within their educational institutions as unique individuals, then they will need to listen attentively to each other.…

  1. 40 CFR Appendix P to Part 51 - Minimum Emission Monitoring Requirements

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... must include in order to be approved under the provisions of 40 CFR 51.165(b). These requirements... in paragraph 2.1 of this appendix, shall be monitored for opacity, nitrogen oxides emissions, sulfur... nitrogen oxides emissions. 1.2 Exemptions. The States may include provisions within their regulations...

  2. 40 CFR Appendix P to Part 51 - Minimum Emission Monitoring Requirements

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... must include in order to be approved under the provisions of 40 CFR 51.165(b). These requirements... in paragraph 2.1 of this appendix, shall be monitored for opacity, nitrogen oxides emissions, sulfur... nitrogen oxides emissions. 1.2 Exemptions. The States may include provisions within their regulations...

  3. Space transfer vehicle concepts and requirements. Volume 2, book 2: Appendix

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This appendix describes the work that was performed to define the Lunar transfer vehicle and Lunar excursion vehicle which were part of the 'Report of the 90-Day Study on Human Exploration of the Moon and Mars.' A detailed concept definition of both vehicles including overall dimensions, mass properties, subsystem definition, and operational flight sequences is included.

  4. 2 CFR Appendix D to Part 225 - Public Assistance Cost Allocation Plans

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... administered by State public assistance agencies include: Temporary Assistance to Needy Families (TANF... approval of public assistance cost allocation plans in Subpart E of 45 CFR part 95. All administrative... in Subpart E of 45 CFR part 95. For the purpose of this appendix, these programs include all...

  5. 2 CFR Appendix D to Part 225 - Public Assistance Cost Allocation Plans

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... administered by State public assistance agencies include: Temporary Assistance to Needy Families (TANF... approval of public assistance cost allocation plans in Subpart E of 45 CFR part 95. All administrative... in Subpart E of 45 CFR part 95. For the purpose of this appendix, these programs include all...

  6. 2 CFR Appendix D to Part 225 - Public Assistance Cost Allocation Plans

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... administered by State public assistance agencies include: Temporary Assistance to Needy Families (TANF... approval of public assistance cost allocation plans in Subpart E of 45 CFR part 95. All administrative... in Subpart E of 45 CFR part 95. For the purpose of this appendix, these programs include all...

  7. Light, Including Ultraviolet

    PubMed Central

    Maverakis, Emanual; Miyamura, Yoshinori; Bowen, Michael P.; Correa, Genevieve; Ono, Yoko; Goodarzi, Heidi

    2009-01-01

    Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory pathways leading to allergy or autoimmunity. In others, this same UV radiation can be used as a phototherapy to suppress pathogenic cutaneous immune responses. These vastly different properties are a direct result of UV light’s ability to ionize molecules in the skin and thereby chemically alter them. Sometimes these UV-induced chemical reactions are essential, the formation of pre-vitamin D3 from 7-dehydrocholesterol, for example. In other instances they can be potentially detrimental. UV radiation can ionize a cell’s DNA causing adjacent pyrimidine bases to chemically bond to each other. To prevent malignant transformation, a cell may respond to this UV-induced DNA damage by undergoing apoptosis. Although this pathway prevents skin cancer it also has the potential of inducing or exacerbating autoreactive immune responses by exposing the cell’s nuclear antigens. Ultaviolet-induced chemical reactions can activate the immune system by a variety of other mechanisms as well. In response to UV irradiation keratinocytes secrete cytokines and chemokines, which activate and recruit leukocytes to the skin. In some individuals UV-induced chemical reactions can synthesize novel antigens resulting in a photoallergy. Alternatively, photosensitizing molecules can damage cells by initiating sunburn-like phototoxic reactions. Herein we review all types of UV-induced skin reactions, especially those involving the immune system. PMID:20018479

  8. Equal Educational Opportunity: Hearings Before the Select Committee on Equal Educational Opportunity of the United States Senate, Ninety-Seond Congress, First Session on Equal Educational Opportunity. Part 16D-1--Inequality in School Finance: General Appendixes.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Equal Educational Opportunity.

    Appendix One, items pertinent to the hearing of September 21, 1971, includes material supplied by Dr. Robert W. Blanchard concerning allocations from Oregon's basic school support fund. Appendix Two, items pertinent to the hearing of September 22, 1971, includes material supplied by Joel B. Berke on "The Current Crisis in School Finance:…

  9. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  10. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  11. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  12. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  13. 30 CFR Appendix I to Subpart J of... - Appendix I to Subpart J of Part 7

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Appendix I to Subpart J of Part 7 I Appendix I to Subpart J of Part 7 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Assemblies Pt. 7, Subpt. J, App. I Appendix I to Subpart J of Part 7 EC22OC91.004 EC22OC91.005...

  14. 40 CFR Appendix W to Part 51 - Guideline on Air Quality Models

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....0Bibliography 12.0References Appendix A to Appendix W of 40 CFR Part 51—Summaries of Preferred Air Quality... assessing source impact and in evaluating control strategies. i. Appendix W to 40 CFR Part 51 itself... to Appendix A to Appendix W to 40 CFR Part 51. Appendix A contains summaries of refined air...

  15. 40 CFR Appendix W to Part 51 - Guideline on Air Quality Models

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....0Bibliography 12.0References Appendix A to Appendix W of 40 CFR Part 51—Summaries of Preferred Air Quality... assessing source impact and in evaluating control strategies. i. Appendix W to 40 CFR Part 51 itself... to Appendix A to Appendix W to 40 CFR Part 51. Appendix A contains summaries of refined air...

  16. 40 CFR Appendix W to Part 51 - Guideline on Air Quality Models

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....0Bibliography 12.0References Appendix A to Appendix W of 40 CFR Part 51—Summaries of Preferred Air Quality... assessing source impact and in evaluating control strategies. i. Appendix W to 40 CFR Part 51 itself... to Appendix A to Appendix W to 40 CFR Part 51. Appendix A contains summaries of refined air...

  17. Horseshoe Appendix: An Extremely Rare Appendiceal Anomaly

    PubMed Central

    Singh, Ch Gyan; Rangaswamy, Raju; Ezung, Yibenthung S.; Singh, H. Manihar

    2016-01-01

    Appendiceal anomalies are extremely rare malformations that are usually found incidentally. Agenesis and duplication of the appendix has been well documented however, the cases of horseshoe appendix reported is very limited, only four cases reported so far. Here, we report a four and half-year-old who underwent interval appendectomy. Intraoperatively both the ends of the appendix were found to be communicating with the cecum with two separate base or stump located at a sagital disposal- the so called “horseshoe appendix”. PMID:27134939

  18. 49 CFR Appendix A to Part 234 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... penalty of up to $105,000 for any violation where circumstances warrant. See 49 CFR part 209, appendix A. ...) Failure to activate horn or whistle 5,000 7,500 234.106Partial activation (a) Failure to notify—train... activate horn or whistle 5,000 7,500 234.107False activation (a) Failure to notify—train crews 5,000...

  19. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?

    PubMed

    Golparian, Daniel; Fernandes, Prabhavathi; Ohnishi, Makoto; Jensen, Jörgen S; Unemo, Magnus

    2012-05-01

    Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.

  20. Villous adenoma of the distal appendix.

    PubMed

    Taylor, J V; Thomas, M G; Kelly, S; Sutton, R

    1997-04-01

    Villous adenoma confined to the distal appendix has not been previously reported in conjunction with acute apendicitis. The presence of an adenoma indicates a need for further investigation due to an association with neoplasia elsewhere.

  1. 33 CFR Appendix D to Part 154 - Training Elements for Oil Spill Response Plans

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Training Elements for Oil Spill... Appendix D to Part 154—Training Elements for Oil Spill Response Plans 1. General 1.1The portion of the plan... contracted oil spill removal organizations and the procedures to notify the activate such organizations....

  2. 33 CFR Appendix D to Part 154 - Training Elements for Oil Spill Response Plans

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Training Elements for Oil Spill... Appendix D to Part 154—Training Elements for Oil Spill Response Plans 1. General 1.1The portion of the plan... contracted oil spill removal organizations and the procedures to notify the activate such organizations....

  3. 33 CFR Appendix D to Part 154 - Training Elements for Oil Spill Response Plans

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Training Elements for Oil Spill... Appendix D to Part 154—Training Elements for Oil Spill Response Plans 1. General 1.1The portion of the plan... contracted oil spill removal organizations and the procedures to notify the activate such organizations....

  4. Elementary, Middle, and High School Guides for Teaching about Human Rights Appendix.

    ERIC Educational Resources Information Center

    Detroit Public Schools, MI. Dept. of Curriculum Development Services.

    This appendix to the guides for teaching about human rights at the elementary, middle, and high school levels features instructional activities and materials which represent a variety of cultural perspectives. Among the topics addressed are the role of values and ethics in decision making, prejudice, racial and ethnic stereotyping, social skills…

  5. 45 CFR Appendix A to Subpart C of... - Security Standards: Matrix

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Sanction Policy (R) Information System Activity Review (R) Assigned Security Responsibility 164.308(a)(2... Monitoring (A) Password Management (A) Security Incident Procedures 164.308(a)(6) Response and Reporting (R... 45 Public Welfare 1 2011-10-01 2011-10-01 false Security Standards: Matrix A Appendix A to...

  6. 17 CFR 248.6 - Information to be included in privacy notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and... Appendix A to Subpart A of this part, Form S-P meets the notice content requirements of this section. (g..., annual, and revised privacy notices that you provide under §§ 248.4, 248.5, and 248.8 must include...

  7. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (including unknown cause, if applicable), as applicable, and the corrective action taken. (m) If there were... that are due to control equipment problems, process problems, other known causes, and other unknown... procedure in 40 CFR part 60, appendix F of this part, as if any of the following occur. (1) The zero...

  8. 40 CFR 1045.205 - What must I include in my application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... engines, if applicable. (b) Explain how the emission control systems operate. Describe in detail all system components for controlling exhaust emissions, including all auxiliary emission control devices... specified in 40 CFR part 1068, Appendix III. For example, engine owners should have ready access...

  9. 40 CFR 1054.205 - What must I include in my application?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... emission control systems operate. Describe the evaporative emission controls and show how your design will... controlling exhaust emissions, including all auxiliary emission control devices (AECDs) and all fuel-system... specified in 40 CFR part 1068, Appendix III. For example, engine owners should have ready access...

  10. Final report from VFL technologies for the pilot-scale thermal treatment of Lower East Fork Poplar Creek floodplain soils: LEFPC appendices, volume 1, appendix I-IV

    SciTech Connect

    1994-09-01

    This document contains Appendix I-IV for the pilot-scale thermal treatment of lower East Fork Poplar Creek floodplain soils. Included are calibration records; quality assurance; soils characterization; pilot scale trial runs.

  11. 40 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 750

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Appendix A to Subpart A of Part 750 A Appendix A to Subpart A of Part 750 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... ACT Procedures for Rulemaking Under Section 6 of the Toxic Substances Control Act Pt. 750, Subpt....

  12. 12 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 327

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... weighted average CAMELS component rating referred to in 12 CFR 327.9(d)(2)(i): Equation 7 PiT = + 30.211... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Appendix A to Subpart A of Part 327 A Appendix A to Subpart A of Part 327 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS...

  13. 40 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 750

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Appendix A to Subpart A of Part 750 A Appendix A to Subpart A of Part 750 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... ACT Procedures for Rulemaking Under Section 6 of the Toxic Substances Control Act Pt. 750, Subpt....

  14. 40 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 750

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Appendix A to Subpart A of Part 750 A Appendix A to Subpart A of Part 750 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... ACT Procedures for Rulemaking Under Section 6 of the Toxic Substances Control Act Pt. 750, Subpt....

  15. 40 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 750

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Appendix A to Subpart A of Part 750 A Appendix A to Subpart A of Part 750 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... ACT Procedures for Rulemaking Under Section 6 of the Toxic Substances Control Act Pt. 750, Subpt....

  16. 44 CFR Appendix A(4) to Part 61 - Appendix A(4) to Part 61

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appendix A(4) to Part 61 A(4) Appendix A(4) to Part 61 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES Pt. 61, App....

  17. 44 CFR Appendix A(5) to Part 61 - Appendix A(5) to Part 61

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appendix A(5) to Part 61 A(5) Appendix A(5) to Part 61 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES Pt. 61, App....

  18. 13 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 113

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Appendix A to Subpart A of Part 113 A Appendix A to Subpart A of Part 113 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FINANCIAL ASSISTANCE PROGRAMS OF SBA-EFFECTUATION OF POLICIES OF FEDERAL GOVERNMENT AND SBA ADMINISTRATOR General Provisions...

  19. 40 CFR Appendix A to Subpart A of... - Appendix A to Subpart A of Part 750

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Appendix A to Subpart A of Part 750 A Appendix A to Subpart A of Part 750 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... ACT Procedures for Rulemaking Under Section 6 of the Toxic Substances Control Act Pt. 750, Subpt....

  20. 44 CFR Appendix A(6) to Part 61 - Appendix A(6) to Part 61

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appendix A(6) to Part 61 A(6) Appendix A(6) to Part 61 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program INSURANCE COVERAGE AND RATES Pt. 61, App....