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Sample records for activities extension activities

  1. Exploring Extension Involvement in Farm to School Program Activities

    ERIC Educational Resources Information Center

    Benson, Matthew C.

    2014-01-01

    The study reported here examined Extension professionals' involvement in farm-to-school program activities. Results of an online survey distributed to eight state Extension systems indicate that on average, Extension professionals are involved with one farm to school program activity, with most supporting school or community garden programs.…

  2. 75 FR 13568 - MMS Information Collection Activity: 1010-0142, Decommissioning Activities, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... Minerals Management Service MMS Information Collection Activity: 1010-0142, Decommissioning Activities, Extension of a Collection; Comment Request AGENCY: Minerals Management Service (MMS), Interior. ACTION... comments to the Department of the Interior; Minerals Management Service; Attention: Cheryl Blundon;...

  3. Enhanced muscle activity during lumbar extension exercise with pelvic stabilization

    PubMed Central

    Lee, Ho-Seong

    2015-01-01

    The purpose of this study was to investigate whether pelvic stabilization affects multifidus (MF) and iliocostalis lumborum (IL) muscle activities during dynamic extension exercise. Nine males (age, 25.1±6.3 yr; height, 176.6±2.4 cm; body mass, 74.9±6.7 kg) performed an isometric lumbar extension strength test and dynamic exercise in an upright seated position with or without pelvic stabilization. The electromyography and muscle strength of the MF and IL muscles were measured when the subjects performed the isometric lumbar extension strength test at the trunk angle 110°, 146°, and 182°. In addition, the trunk extensor muscle activities were measured using 50% muscle strength of maximum isometric strength during a dynamic trunk extension exercise. The MF and IL muscle activities were significantly higher at 110°, 146°, and 182° with pelvic stabilization than that without pelvic stabilization during the isometric lumbar extension strength test (P<0.05) and the dynamic exercise (P<0.05). These results suggest that the lumbar extension exercise with pelvic stabilization may be more effective for MF and IL muscle activity compared to that without pelvic stabilization. PMID:26730390

  4. 75 FR 48921 - Administrative Guidance for Multistate Extension Activities and Integrated Research and Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... with these requirements. Section 105 of AREERA amended the Smith-Lever Act to require that a specified... 204 of AREERA amended the Hatch Act and Smith-Lever Act to require that a specified amount of... Smith- Lever Act funds on multistate extension activities and 25 percent on integrated research...

  5. Using Non-Extension Volunteering as an Experiential Learning Activity for Extension Professionals

    ERIC Educational Resources Information Center

    Andrews, Kevin B.; Lockett, Landry L.

    2013-01-01

    Extension professionals can gain much-needed competencies in volunteer administration through experiential learning by participating in volunteer activities. Experiential learning is a means of behavior change that allows the individual learner to reflect on, abstract, and apply their experiences to new situations. This article expands on…

  6. Three determinants in ezrin are responsible for cell extension activity.

    PubMed Central

    Martin, M; Roy, C; Montcourrier, P; Sahuquet, A; Mangeat, P

    1997-01-01

    The ERM proteins--ezrin, radixin, and moesin--are key players in membrane-cytoskeleton interactions. In insect cells infected with recombinant baculoviruses, amino acids 1-115 of ezrin were shown to inhibit an actin- and tubulin-dependent cell-extension activity located in ezrin C-terminal domain (ezrin310-586), whereas full-length ezrin1-586 did not induce any morphological change. To refine the mapping of functional domains of ezrin, 30 additional constructs were overexpressed in Sf9 cells, and the resulting effect of each was qualitatively and semiquantitatively compared. The removal of amino acids 13-30 was sufficient to release a cell-extension phenotype. This effect was abrogated if the 21 distal-most C-terminal amino acids were subsequently deleted (ezrin31-565), confirming the existence of a head-to-tail regulation in the whole molecule. Surprisingly, the deletion in full-length ezrin of the same 21 amino acids provided strong cell-extension competence to ezrin1-565, and this property was recovered in N-terminal constructs as short as ezrin1-310. Within ezrin1-310, amino acid sequences 13-30 and 281-310 were important determinants and acted in cooperation to induce cytoskeleton mobilization. In addition, these same residues are part of a new actin-binding site characterized in vitro in ezrin N-terminal domain. Images PMID:9285824

  7. Passive resting state and history of antagonist muscle activity shape active extensions in an insect limb.

    PubMed

    Ache, Jan M; Matheson, Thomas

    2012-05-01

    Limb movements can be driven by muscle contractions, external forces, or intrinsic passive forces. For lightweight limbs like those of insects or small vertebrates, passive forces can be large enough to overcome the effects of gravity and may even generate limb movements in the absence of active muscle contractions. Understanding the sources and actions of such forces is therefore important in understanding motor control. We describe passive properties of the femur-tibia joint of the locust hind leg. The resting angle is determined primarily by passive properties of the relatively large extensor tibiae muscle and is influenced by the history of activation of the fast extensor tibiae motor neuron. The resting angle is therefore better described as a history-dependent resting state. We selectively stimulated different flexor tibiae motor neurons to generate a range of isometric contractions of the flexor tibiae muscle and then stimulated the fast extensor tibiae motor neuron to elicit active tibial extensions. Residual forces in the flexor muscle have only a small effect on subsequent active extensions, but the effect is larger for distal than for proximal flexor motor neurons and varies with the strength of flexor activation. We conclude that passive properties of a lightweight limb make substantial and complex contributions to the resting state of the limb that must be taken into account in the patterning of neuronal control signals driving its active movements. Low variability in the effects of the passive forces may permit the nervous system to accurately predict their contributions to behavior. PMID:22357791

  8. Trunk stiffness and dynamics during active extension exertions.

    PubMed

    Moorhouse, Kevin M; Granata, Kevin P

    2005-10-01

    Spinal stability is related to the recruitment and control of active muscle stiffness. Stochastic system identification techniques were used to calculate the effective stiffness and dynamics of the trunk during active trunk extension exertions. Twenty-one healthy adult subjects (10 males, 11 females) wore a harness with a cable attached to a servomotor such that isotonic flexion preloads of 100, 135, and 170 N were applied at the T10 level of the trunk. A pseudorandom stochastic force sequence (bandwidth 0-10 Hz, amplitude +/-30 N) was superimposed on the preload causing small amplitude trunk movements. Nonparametric impulse response functions of trunk dynamics were computed and revealed that the system exhibited underdamped second-order behavior. Second-order trunk dynamics were determined by calculating the best least-squares fit to the IRF. The quality of the model was quantified by comparing estimated and observed displacement variance accounted for (VAF), and quality of the second-order fits was calculated as a percentage and referred to as fit accuracy. Mean VAF and fit accuracy were 87.8 +/- 4.0% and 96.0 +/- 4.3%, respectively, indicating that the model accurately represented active trunk kinematic response. The accuracy of the kinematic representation was not influenced by preload or gender. Mean effective stiffness was 2.78 +/- 0.96 N/mm and increased significantly with preload (p < 0.001), but did not vary with gender (p = 0.425). Mean effective damping was 314 +/- 72 Ns/m and effective trunk mass was 37.0 +/- 9.3 kg. We conclude that stochastic system identification techniques should be used to calculate effective trunk stiffness and dynamics. PMID:16084200

  9. An Extensible, User- Modifiable Framework for Planning Activities

    NASA Technical Reports Server (NTRS)

    Joshing, Joseph C.; Abramyan, Lucy; Mickelson, Megan C.; Wallick, Michael N.; Kurien, James A.; Crockett, Thomasa M.; Powell, Mark W.; Pyrzak, Guy; Aghevli, Arash

    2013-01-01

    This software provides a development framework that allows planning activities for the Mars Science Laboratory rover to be altered at any time, based on changes of the Activity Dictionary. The Activity Dictionary contains the definition of all activities that can be carried out by a particular asset (robotic or human). These definitions (and combinations of these definitions) are used by mission planners to give a daily plan of what a mission should do. During the development and course of the mission, the Activity Dictionary and actions that are going to be carried out will often be changed. Previously, such changes would require a change to the software and redeployment. Now, the Activity Dictionary authors are able to customize activity definitions, parameters, and resource usage without requiring redeployment. This software provides developers and end users the ability to modify the behavior of automatically generated activities using a script. This allows changes to the software behavior without incurring the burden of redeployment. This software is currently being used for the Mars Science Laboratory, and is in the process of being integrated into the LADEE (Lunar Atmosphere and Dust Environment Explorer) mission, as well as the International Space Station.

  10. Activity.

    ERIC Educational Resources Information Center

    Clearing: Nature and Learning in the Pacific Northwest, 1984

    1984-01-01

    Presents three activities: (1) investigating succession in a schoolground; (2) investigating oak galls; and (3) making sun prints (photographs made without camera or darkroom). Each activity includes a list of materials needed and procedures used. (JN)

  11. Assessing adult leisure activities: an extension of a self-report activity questionnaire.

    PubMed

    Jopp, Daniela S; Hertzog, Christopher

    2010-03-01

    Everyday leisure activities in adulthood and old age have been investigated with respect to constructs such as successful aging, an engaged lifestyle, and prevention of age-related cognitive decline. They also relate to mental health and have clinical value, as they can inform diagnosis and interventions. In the present study, the authors enhanced the content validity of the Victoria Longitudinal Study activity questionnaire by adding items on physical and social activities and validated a shortened version of the questionnaire. The proposed leisure activity model included 11 activity categories: 3 types of social activities (i.e., activities with close social partners, group-centered public activity, religious activities), physical activities, developmental activities, experiential activities, crafts, game playing, TV watching, travel, and technology use. Confirmatory factor analyses validated the proposed factor structure in 2 independent samples. A higher order model with a general activity factor fitted the activity factor correlations with relatively little loss of fit. Convergent and discriminant validity for the activity scales were supported by patterns of their correlations with education, health, depression, cognition, and personality. In sum, the scores derived from of the augmented Victoria Longitudinal Study activity questionnaire demonstrate good reliability, and validity evidence supports their use as measures of leisure activities in young, middle-aged, and older individuals. PMID:20230157

  12. A National Perspective on the Current Evaluation Activities in Extension

    ERIC Educational Resources Information Center

    Lamm, Alexa J.; Israel, Glenn D.; Diehl, David

    2013-01-01

    In order to enhance Extension evaluation efforts it is important to understand current practices. The study reported here researched the evaluation behaviors of county-based Extension professionals. Extension professionals from eight states (n = 1,173) responded to a survey regarding their evaluation data collection, analysis, and reporting…

  13. Assessing Adult Leisure Activities: An Extension of a Self-Report Activity Questionnaire

    PubMed Central

    Jopp, Daniela; Hertzog, Christopher

    2009-01-01

    Everyday leisure activities in adulthood and old age have been investigated with respect to constructs such as successful aging, an engaged lifestyle, and prevention of age-related cognitive decline. They also relate to mental health and have clinical value as they can inform diagnosis and interventions. In the present study, we enhanced the content validity of the Victoria Longitudinal Study activity questionnaire by adding items on physical and social activities, and validated a shortened version of the questionnaire. Our proposed leisure activity model included 11 activity categories: three types of social activities (i.e., activities with close social partners, group-centered public activity, religious activities), physical, developmental, and experiential activities, crafts, game playing, TV watching, travel, and technology use. Confirmatory factor analyses validated the proposed factor structure in two independent samples. A higher-order model with a general activity factor fitted the activity factor correlations with relatively little loss of fit. Convergent and discriminant validity for the activity scales were supported by patterns of their correlations with education, health, depression, cognition, and personality. In sum, the scores derived from of the augmented VLS activity questionnaire demonstrate good reliability, and validity evidence supports their use as measure of leisure activities in young, middle-aged, and older individuals. PMID:20230157

  14. Activities.

    ERIC Educational Resources Information Center

    Moody, Mally

    1992-01-01

    A series of four activities are presented to enhance students' abilities to appreciate and use trigonometry as a tool in problem solving. Activities cover problems applying the law of sines, the law of cosines, and matching equivalent trigonometric expressions. A teacher's guide, worksheets, and answers are provided. (MDH)

  15. Activities.

    ERIC Educational Resources Information Center

    Kincaid, Charlene; And Others

    1993-01-01

    Presents an activity in which students collect and organize data from a real-world simulation of the scientific concept of half life. Students collect data using a marble sifter, analyze the data using a graphing calculator, and determine an appropriate mathematical model. Includes reproducible worksheets. (MDH)

  16. Life Extension Activities for the Hubble Space Telescope

    NASA Technical Reports Server (NTRS)

    Walyus, Keith D.; Pepe, Joyce A. K.; Prior, Michael

    2004-01-01

    With the cancellation of the Hubble Space Telescope (HST) Servicing Mission 4 (SM4), the HST Project will face numerous challenges to keep the Telescope operating during the remainder of the decade. As part of the SM4, the HST Project had planned to install various upgrades to the Telescope including the installation of new batteries and new rate integrating gyros. Without these upgrades, reliability analysis indicates that the spacecraft will lose the capability to conduct science operations later this decade. The HST team will be severely challenged to maximize the Telescope's remaining operational lifetime, while still trying to maximize - its science output and quality. Two of the biggest areas of concern are the age and condition of the batteries and gyros. Together they offer the largest potential extension in Telescope lifetime and present the biggest challenges to the HST team. The six Ni-H batteries on HST are the original batteries from launch. With fourteen years of operational life, these batteries have collectively lasted longer than any other comparable mission. Yet as with all batteries, their capacity has been declining. Engineers are examining various methods to prolong the life of these mission critical batteries, and retard the rate of degradation. This paper will focus on these and other efforts to prolong the life of the HST, thus enabling it to remain a world-class observatory for as long as possible.

  17. 75 FR 42816 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... agencies to evaluate changes in truck travel in order to assess impacts on highway safety; the role of... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA),...

  18. 78 FR 77484 - Extension of Agency Information Collection Activity Under OMB Review: Pipeline System Operator...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... period soliciting comments, of the following collection of information on August 16, 2013, 78 FR 50077. Specifically, the collection involves the submission of contact information for a pipeline company's primary... SECURITY Transportation Security Administration Extension of Agency Information Collection Activity...

  19. 75 FR 49946 - National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension With Change... Response System. The United States Department of Justice (DOJ), National Drug Intelligence Center (NDIC... Intelligence Center, Fifth Floor, 319 Washington Street, Johnstown, PA 15901. Written comments and...

  20. 78 FR 5504 - Agency Information Collection Activities: Extension of Information Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... NATIONAL INTELLIGENCE Agency Information Collection Activities: Extension of Information Collection; Comment Request AGENCY: Office of the Director of National Intelligence (ODNI). ACTION: Notice and comment... are directly related to responsibilities assigned to the Director of National Intelligence (DNI)...

  1. 78 FR 61868 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of Currently Approved Collection: Bureau of Justice Assistance Application Form; Law...

  2. 78 FR 45971 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of Currently Approved Collection; Bureau of Justice Assistance Application Form: Law...

  3. 7 CFR 3400.22 - Merit review for education and extension activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... GRANTS PROGRAM Peer and Merit Review Arranged by Grantees § 3400.22 Merit review for education and extension activities. Merit review is an evaluation of a proposed project or elements of a proposed...

  4. 78 FR 63493 - Agency Information Collection Activities; Extension of a Currently Approved Collection: Semi...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Agency Information Collection Activities; Extension of a Currently Approved Collection: Semi-Annual Progress Report... sexual assault, domestic violence, dating violence, and stalking and to foster partnerships...

  5. 75 FR 77940 - Agency Information Collection Activities; Extension of a Currently-Approved Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Extension of a... AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice and request for comments... identify designated/restricted routes and restrictions or limitations affecting how motor carriers...

  6. Assessing Adult Leisure Activities: An Extension of a Self-Report Activity Questionnaire

    ERIC Educational Resources Information Center

    Jopp, Daniela S.; Hertzog, Christopher

    2010-01-01

    Everyday leisure activities in adulthood and old age have been investigated with respect to constructs such as successful aging, an engaged lifestyle, and prevention of age-related cognitive decline. They also relate to mental health and have clinical value, as they can inform diagnosis and interventions. In the present study, the authors enhanced…

  7. 75 FR 54363 - BOEMRE Information Collection Activity: 1010-0142, Decommissioning Activities, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... 22, 2010, we published a Federal Register notice (75 FR 13568) announcing that we would submit this... Bureau of Ocean Energy Management, Regulation and Enforcement BOEMRE Information Collection Activity... and Budget (OMB) Review; Comment Request AGENCY: Bureau of Ocean Energy Management, Regulation...

  8. 77 FR 14829 - Agency Information Collection Activities: Extension of a Currently Approved Collection; Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... Information Collection Activities: Extension of a Currently Approved Collection; Comments Requested COPS... Justice (DOJ) Office of Community Oriented Policing Services (COPS), will be submitting the following.... Department of Justice COPS Office would require the completion of the Extension Request Form from...

  9. 75 FR 25292 - Agency Information Collection Activities: Extension of a Currently Approved Collection: Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... at M.A.Berry@ojp.usdoj.gov . Written comments and suggestions from the public and affected agencies... of Justice Programs Agency Information Collection Activities: Extension of a Currently Approved Collection: Comments Requested ACTION: 30-Day Notice of information collection under review: Extension of...

  10. 75 FR 14185 - Agency Information Collection Activities: Extension of a Currently Approved Collection: Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...-mail at M.A.Berry@ojp.usdoj.gov . Written comments and suggestions from the public and affected... of Justice Programs Agency Information Collection Activities: Extension of a Currently Approved Collection: Comments Requested ACTION: 30 Day Notice of Information Collection Under Review: Extension of...

  11. 77 FR 31065 - Agency Information Collection Activities; Extension of a Currently-Approved Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ...: Applications for Motor Carrier Operating Authority. OMB Control Number: 2126-0016. Type of Request: Extension... Motor Carrier Safety Administration, 6th Floor, West Building, 1200 New Jersey Ave. SE., Washington, DC... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Extension of...

  12. Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo.

    PubMed

    Alam, Md Rowshon; Majumdar, Alokes; Thazhathveetil, Arun Kalliat; Liu, Su-Ting; Liu, Ji-Lan; Puri, Nitin; Cuenoud, Bernard; Sasaki, Shigeki; Miller, Paul S; Seidman, Michael M

    2007-09-01

    We are developing triple helix forming oligonucleotides (TFOs) for gene targeting. Previously, we synthesized bioactive TFOs containing 2'-O-methylribose (2'-OMe) and 2'-O-aminoethylribose (2'-AE) residues. Active TFOs contained four contiguous 2'-AE residues and formed triplexes with high thermal stability and rapid association kinetics. In an effort to further improve bioactivity, we synthesized three series of TFOs containing the 2'-AE patch and additional ribose modifications distributed throughout the remainder of the oligonucleotide. These were either additional 2'-AE residues, the conformationally locked BNA/LNA ribose with a 2'-O,4'-C-methylene bridge, or the 2'-O,4'-C-ethylene analogue (ENA). The additionally modified TFOs formed triplexes with greater thermal stability than the reference TFO, and some had improved association kinetics. However, the most active TFOs in the biochemical and biophysical assays were the least active in the bioassay. We measured the thermal stability of triplexes formed by the TFOs in each series on duplex targets containing a change in sequence at a single position. The Tm value of the variant sequence triplexes increased as the number of all additional modifications increased. A simple explanation for the failure of the improved TFOs in the bioassay was that the increased affinity for nonspecific targets lowered the effective nuclear concentration. Enhancement of TFO bioactivity will require chemical modifications that improve interaction with the specific targets while retaining selectivity against mismatched sequences. PMID:17691818

  13. WGEF activates Rho in the Wnt–PCP pathway and controls convergent extension in Xenopus gastrulation

    PubMed Central

    Tanegashima, Kosuke; Zhao, Hui; Dawid, Igor B

    2008-01-01

    The Wnt–PCP (planar cell polarity, PCP) pathway regulates cell polarity and convergent extension movements during axis formation in vertebrates by activation of Rho and Rac, leading to the re-organization of the actin cytoskeleton. Rho and Rac activation require guanine nucleotide-exchange factors (GEFs), but the identity of the GEF involved in Wnt–PCP-mediated convergent extension is unknown. Here we report the identification of the weak-similarity GEF (WGEF) gene by a microarray-based screen for notochord enriched genes, and show that WGEF is involved in Wnt-regulated convergent extension. Overexpression of WGEF activated RhoA and rescued the suppression of convergent extension by dominant-negative Wnt-11, whereas depletion of WGEF led to suppression of convergent extension that could be rescued by RhoA or Rho-associated kinase activation. WGEF protein preferentially localized at the plasma membrane, and Frizzled-7 induced colocalization of Dishevelled and WGEF. WGEF protein can bind to Dishevelled and Daam-1, and deletion of the Dishevelled-binding domain generates a hyperactive from of WGEF. These results indicate that WGEF is a component of the Wnt–PCP pathway that connects Dishevelled to Rho activation. PMID:18256687

  14. WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation.

    PubMed

    Tanegashima, Kosuke; Zhao, Hui; Dawid, Igor B

    2008-02-20

    The Wnt-PCP (planar cell polarity, PCP) pathway regulates cell polarity and convergent extension movements during axis formation in vertebrates by activation of Rho and Rac, leading to the re-organization of the actin cytoskeleton. Rho and Rac activation require guanine nucleotide-exchange factors (GEFs), but the identity of the GEF involved in Wnt-PCP-mediated convergent extension is unknown. Here we report the identification of the weak-similarity GEF (WGEF) gene by a microarray-based screen for notochord enriched genes, and show that WGEF is involved in Wnt-regulated convergent extension. Overexpression of WGEF activated RhoA and rescued the suppression of convergent extension by dominant-negative Wnt-11, whereas depletion of WGEF led to suppression of convergent extension that could be rescued by RhoA or Rho-associated kinase activation. WGEF protein preferentially localized at the plasma membrane, and Frizzled-7 induced colocalization of Dishevelled and WGEF. WGEF protein can bind to Dishevelled and Daam-1, and deletion of the Dishevelled-binding domain generates a hyperactive from of WGEF. These results indicate that WGEF is a component of the Wnt-PCP pathway that connects Dishevelled to Rho activation. PMID:18256687

  15. 77 FR 21104 - Agency Information Collection Activities: Form I-694, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... a brief abstract: Primary: Individuals and households. USCIS uses the information provided on Form I... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-694, Extension of a Currently Approved Information Collection; Comment Request ACTION: 60-Day Notice...

  16. 75 FR 52541 - Agency Information Collection Activities: Form I-243, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... published in the Federal Register on June 9, 2010, at 75 FR 32799, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-243, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice...

  17. 76 FR 20361 - Agency Information Collection Activities: Form I-694, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-694, Extension of a Currently Approved Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review: Form I- 694, Notice of Appeal of Decision Under Section 210 or 245A;...

  18. 76 FR 20362 - Agency Information Collection Activities: Form I-905, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-905, Extension of a Currently Approved Information Collection; Comment Request Action: 60-Day Notice of Information Collection Under Review: Form I- 905, Application for Authorization To Issue Certification...

  19. 76 FR 69275 - Agency Information Collection Activities: Form I-192, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... the Federal Register on August 12, 2011, at 76 FR 50239, allowing for a 60- day public comment period... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-192, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice...

  20. 76 FR 20361 - Agency Information Collection Activities: Form I-907, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-907, Extension of a Currently Approved Information Collection; Comment Request ACTION: 60-day notice of information collection under review: Form I- 907, Request for Premium Processing Service; OMB Control No....

  1. 77 FR 23734 - Agency Information Collection Activities: Form I-361, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ..., 2012, at 77 FR 9259, allowing for a 60-day public comment period. USCIS did not receive any comments... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-361, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice...

  2. 75 FR 52541 - Agency Information Collection Activities: Form I-865, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... was previously published in the Federal Register on June 9, 2010, at 75 FR 32801, allowing for a 60... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-865, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice...

  3. 75 FR 11898 - Agency Information Collection Activities: Form I-612, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-612, Extension of a Currently Approved Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review: Form I- 612, Application for Waiver of the Foreign Residence...

  4. 76 FR 43335 - Agency Information Collection Activities: Form I-765, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... collection was previously published in the Federal Register on April 19, 2011, at 76 FR 21912 allowing for a... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-765, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day Notice...

  5. 7 CFR 3400.22 - Merit review for education and extension activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Merit review for education and extension activities. 3400.22 Section 3400.22 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SPECIAL RESEARCH GRANTS PROGRAM Peer and Merit Review Arranged by...

  6. 7 CFR 3400.22 - Merit review for education and extension activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Merit review for education and extension activities. 3400.22 Section 3400.22 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SPECIAL RESEARCH GRANTS PROGRAM Peer and Merit Review Arranged by...

  7. 7 CFR 3400.22 - Merit review for education and extension activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Merit review for education and extension activities. 3400.22 Section 3400.22 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE SPECIAL RESEARCH GRANTS PROGRAM Peer and Merit Review Arranged by...

  8. 78 FR 36582 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension With Change of a Previously Approved Collection: National Drug Threat Survey ACTION: 30-Day Notice. The United States...

  9. 78 FR 12789 - Agency Information Collection Activities; Extension of a Currently Approved Collection: Office on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... Information Collection Activities; Extension of a Currently Approved Collection: Office on Violence Against Women Solicitation Template ACTION: 60-Day Notice. The Department of Justice, Office on Violence Against... Cathy Poston, Office on Violence Against Women, at 202-514-5430. Written comments and suggestions...

  10. 75 FR 28818 - Office on Violence Against Women; Agency Information Collection Activities: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-24

    ... on Violence Against Women; Agency Information Collection Activities: Extension of a Currently... Report for the Technical Assistance Program. ] The Department of Justice, Office on Violence Against...- 0017. U.S. Department of Justice, Office on Violence Against Women. (4) Affected public who will...

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  13. Pacific Northwest USDA-ARS Jointed Goatgrass Research and Extension Activities

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The USDA-ARS weed scientists have conducted research and extension activities on six research projects funded by the National Jointed Goatgrass Research Program (NJGGRP). This poster reviews the objectives and major research findings from these federally funded projects. Most of these projects wer...

  14. 75 FR 70030 - Agency Information Collection Activities: Extension of a Currently Approved Collection

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  18. 77 FR 13136 - Agency Information Collection Activities: Form I-134; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

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  19. 32 CFR 767.8 - Requests for amendments or extensions of active permits.

    Code of Federal Regulations, 2011 CFR

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    Code of Federal Regulations, 2013 CFR

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    Code of Federal Regulations, 2010 CFR

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    Code of Federal Regulations, 2012 CFR

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... December 29, 2010 (75 FR 82133). Public Participation: The Federal eRulemaking Portal is available 24 hours... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Extension of a... Reduction Act of 1995, FMCSA announces its plan to submit the Information Collection Request (ICR)...

  8. 76 FR 41282 - Agency Information Collection Activities: Form I-363, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

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  9. Mirror therapy in a patient with a fractured wrist and no active wrist extension.

    PubMed

    Altschuler, Eric L; Hu, Jeong

    2008-01-01

    We report a patient in whom mirror therapy, training moving both hands while watching the reflection of the present or good hand in a parasaggital mirror - a method used for phantom limb and stroke patients - was extremely useful after a fractured wrist with good passive, but no active, extension. PMID:18335358

  10. Non-extensivity and complexity in the earthquake activity at the West Corinth rift (Greece)

    NASA Astrophysics Data System (ADS)

    Michas, Georgios; Vallianatos, Filippos; Sammonds, Peter

    2013-04-01

    Earthquakes exhibit complex phenomenology that is revealed from the fractal structure in space, time and magnitude. For that reason other tools rather than the simple Poissonian statistics seem more appropriate to describe the statistical properties of the phenomenon. Here we use Non-Extensive Statistical Physics [NESP] to investigate the inter-event time distribution of the earthquake activity at the west Corinth rift (central Greece). This area is one of the most seismotectonically active areas in Europe, with an important continental N-S extension and high seismicity rates. NESP concept refers to the non-additive Tsallis entropy Sq that includes Boltzmann-Gibbs entropy as a particular case. This concept has been successfully used for the analysis of a variety of complex dynamic systems including earthquakes, where fractality and long-range interactions are important. The analysis indicates that the cumulative inter-event time distribution can be successfully described with NESP, implying the complexity that characterizes the temporal occurrences of earthquakes. Further on, we use the Tsallis entropy (Sq) and the Fischer Information Measure (FIM) to investigate the complexity that characterizes the inter-event time distribution through different time windows along the evolution of the seismic activity at the West Corinth rift. The results of this analysis reveal a different level of organization and clusterization of the seismic activity in time. Acknowledgments. GM wish to acknowledge the partial support of the Greek State Scholarships Foundation (IKY).

  11. Extensive training leads to temporal and spatial shifts of cortical activity underlying visual category selectivity.

    PubMed

    Kietzmann, Tim C; Ehinger, Benedikt V; Porada, Danja; Engel, Andreas K; König, Peter

    2016-07-01

    The human visual system is able to distinguish naturally occurring categories with exceptional speed and accuracy. At the same time, it exhibits substantial plasticity, permitting the seamless and fast learning of entirely novel categories. Here we investigate the interplay of these two processes by asking how category selectivity emerges and develops from initial to extended category learning. For this purpose, we combine a rapid event-related MEG adaptation paradigm, an extension of fMRI adaptation to high temporal resolution, a novel spatiotemporal analysis approach to separate adaptation effects from other effect origins, and source localization. The results demonstrate a spatiotemporal shift of cortical activity underlying category selectivity: after initial category acquisition, the onset of category selectivity was observed starting at 275ms together with stronger activity in prefrontal cortex. Following extensive training over 22 sessions, adding up to more than 16.600 trials, the earliest category effects occurred at a markedly shorter latency of 113ms and were accompanied by stronger occipitotemporal activity. Our results suggest that the brain balances plasticity and efficiency by relying on different mechanisms to recognize new and re-occurring categories. PMID:27063060

  12. The "Conflicted Dying": The Active Search for Life Extension in Advanced Cancer Through Biomedical Treatment.

    PubMed

    Mohammed, Shan; Peter, Elizabeth; Gastaldo, Denise; Howell, Doris

    2016-03-01

    Using a poststructural perspective, we examine the subjectivities that are produced when advanced cancer patients seek life extension through biomedical treatments. Seven case studies were developed that included 20 interviews with patients, family, nurses, and physicians recruited from a tertiary hospital in Canada, 30 documents, and 5 hours of participant observation. We identify seven types of subjectivity: (a) the Desperate Subject, (b) the Cancer Expert Subject, (c) the Proactive Subject, (d) the Productive Subject, (e) the Mistrusting Subject, (f) the Model Patient Subject, and (g) the Suffering Subject. We characterize the "conflicted dying," a contemporary figure who holds multiple perspectives about seeking curative treatment despite the acknowledgment of death. Using active strategies to gain access to treatment, this figure resists traditional arrangements of power/knowledge established by health care providers. We suggest that the search for life extension is a process of shaping the self to fit certain aesthetical traits associated with surviving cancer. PMID:25711844

  13. Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain

    PubMed Central

    1995-01-01

    Overexpression in insect cells of the full coding sequence of the human membrane cytoskeletal linker ezrin (1-586) was compared with that of a NH2-terminal domain (ezrin 1-233) and that of a COOH-terminal domain (ezrin 310-586). Ezrin (1-586), as well as ezrin (1-233) enhanced cell adhesion of infected Sf9 cells without inducing gross morphological changes in the cell structure. Ezrin (310-586) enhanced cell adhesion and elicited membrane spreading followed by microspike and lamellipodia extensions by mobilization of Sf9 cell actin. Moreover some microspikes elongated into thin processes, up to 200 microns in length, resembling neurite outgrowths by a mechanism requiring microtubule assembly. Kinetics of videomicroscopic and drug-interference studies demonstrated that mobilization of actin was required for tubulin assembly to proceed. A similar phenotype was observed in CHO cells when a comparable ezrin domain was transiently overexpressed. The shortest domain promoting cell extension was localized between residues 373-586. Removal of residues 566-586, involved in in vitro actin binding (Turunen, O., T. Wahlstrom, and A. Vaheri. 1994. J. Cell Biol. 126:1445- 1453), suppressed the extension activity. Coexpression of ezrin (1-233) with ezrin (310-586) in the same insect cells blocked the constitutive activity of ezrin COOH-terminal domain. The inhibitory activity was mapped within ezrin 115 first NH2-terminal residues. We conclude that ezrin has properties to promote cell adhesion, and that ezrin NH2- terminal domain negatively regulates membrane spreading and elongation properties of ezrin COOH-terminal domain. PMID:7896873

  14. Exploring the Gap for Effective Extension of Professional Active Life in Europe

    NASA Astrophysics Data System (ADS)

    Leonard, Will; Afsarmanesh, Hamideh; Msanjila, Simon S.; Playfoot, Jim

    Extending Professional Active Life (ePAL [2]) of elder people in Europe is affected by a number of factors in the market and society, which have the potential to either positively and negatively influence it. Current practices indicate that the European society, while started to act on this subject, is still slow to recognize the rationale behind and importance of fully supporting the extension of active professional life of seniors. Similarly, the capacity of the service sector to fully support the involvement of seniors in economical activities is at present limited, given the huge number of these seniors in different countries who need to be mobilized. This paper seeks to highlight the identified gaps related to effective mechanisms by which Europe can support its willing senior professionals to remain active. The study on gap identification addresses relevant technological, social, and organizational factors and external influences which have the potential to impact successful future life of elderly population. It also presents the methodology that is applied in our study to identify and analyze the gaps between the current practices in this area, the so-called baseline [2], and the desired future for this area as inspired in the ePAL vision [1] addressed in other research.

  15. 76 FR 43654 - Certain Activated Carbon From the People's Republic of China: Extension of Time Limit for Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-21

    ... Preliminary Rescission in Part: Certain Activated Carbon from the People's Republic of China, 75 FR 23978... International Trade Administration Certain Activated Carbon From the People's Republic of China: Extension of... the antidumping duty administrative review on certain activated carbon from the People's Republic...

  16. 75 FR 39916 - Certain Activated Carbon from the People's Republic of China: Extension of Time Limit for Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... International Trade Administration A-570-904 Certain Activated Carbon from the People's Republic of China... initiation of the antidumping duty administrative review on certain activated carbon from the People's... Activated Carbon from the People's Republic of China: Extension of Time Limits for Preliminary Results...

  17. 75 FR 61126 - Certain Activated Carbon From the People's Republic of China: Extension of Time Limit for Final...

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    ... International Trade Administration Certain Activated Carbon From the People's Republic of China: Extension of... the antidumping duty administrative review on certain activated carbon from the People's Republic of... results of this review. See Certain Activated Carbon From the People's Republic of China: Notice...

  18. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation

    PubMed Central

    Johmura, Yoshikazu; Yamashita, Emiri; Shimada, Midori; Nakanishi, Keiko; Nakanishi, Makoto

    2016-01-01

    Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1-dependent G2 checkpoint activation and sensitizes cells to senescence through enhancement of mitosis skipping. Extension of G2 checkpoint activation by introduction of the TopBP1 activation domain and the nondegradable mutant of Claspin sensitizes cells to senescence. In contrast, a shortening of G2 checkpoint activation by expression of SIRT6 or depletion of OTUB2 reduces susceptibility to senescence. Fibroblasts from progeroid syndromes tested shows a correlation between an extension of G2 checkpoint activation and an increase in the susceptibility to senescence. These results suggest that extension of G2 checkpoint activation caused by defective DNA repair is critical for senescence predisposition in progeroid syndrome patients. PMID:27507734

  19. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation.

    PubMed

    Johmura, Yoshikazu; Yamashita, Emiri; Shimada, Midori; Nakanishi, Keiko; Nakanishi, Makoto

    2016-01-01

    Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1-dependent G2 checkpoint activation and sensitizes cells to senescence through enhancement of mitosis skipping. Extension of G2 checkpoint activation by introduction of the TopBP1 activation domain and the nondegradable mutant of Claspin sensitizes cells to senescence. In contrast, a shortening of G2 checkpoint activation by expression of SIRT6 or depletion of OTUB2 reduces susceptibility to senescence. Fibroblasts from progeroid syndromes tested shows a correlation between an extension of G2 checkpoint activation and an increase in the susceptibility to senescence. These results suggest that extension of G2 checkpoint activation caused by defective DNA repair is critical for senescence predisposition in progeroid syndrome patients. PMID:27507734

  20. Extension of polyphenolics by CWPO-C peroxidase mutant containing radical-robust surface active site.

    PubMed

    Pham, L T Mai; Kim, S Jin; Ahn, U Suk; Choi, J Weon; Song, B Keun; Kim, Y Hwan

    2014-01-01

    Expressed as insoluble forms in Escherichia coli, native cationic cell wall peroxidase (CWPO-C) from the poplar tree and mutant variants were successfully reactivated via refolding experiments and used to elucidate the previously presumed existence of an electron transfer (ET) pathway in the CWPO-C structure. Their catalytic properties were fully characterized through various analyses including steady-state kinetic, direct oxidation of lignin macromolecules and their respective stabilities during the polymerization reactions. The analysis results proved that the 74th residue on the CWPO-C surface plays an important role in catalyzing the macromolecules via supposed ET mechanism. By comparing the residual activities of wild-type CWPO-C and mutant 74W CWPO-C after 3 min, mutation of tyrosine 74 residue to tryptophan increased the radical resistance of peroxidase up to ten times dramatically while maintaining its capability to oxidize lignin macromolecules. Furthermore, extension of poly(catechin) as well as lignin macromolecules with CWPO-C Y74W mutant clearly showed that this radical-resistant peroxidase mutant can increase the molecular weight of various kinds of polyphenolics by using surface-located active site. The anti-oxidation activity of the synthesized poly(catechin) was confirmed by xanthine oxidase assay. The elucidation of a uniquely catalytic mechanism in CWPO-C may improve the applicability of the peroxidase/H2O2 catalyst to green polymer chemistry. PMID:24122664

  1. Active shallow extension in central and eastern Betic Cordillera from CGPS data

    NASA Astrophysics Data System (ADS)

    Galindo-Zaldivar, J.; Gil, A. J.; Sanz de Galdeano, C.; Lacy, M. C.; García-Armenteros, J. A.; Ruano, P.; Ruiz, A. M.; Martínez-Martos, M.; Alfaro, P.

    2015-11-01

    The Betic Cordillera is an Alpine belt formed in the western Mediterranean by the westward displacement of the Alboran Domain in between the Eurasian and African convergent plates. New CGPS data from the central and eastern Betic Cordillera and its foreland-obtained mainly from the Topo-Iberia project-allowed us to precisely determine the rate of tectonic deformation. Most of the displacements of the central and eastern Betics are westward, with a variable southwestward component, in relation to the Eurasian stable plate. While in the Iberian foreland the displacements are extremely low, some deformation related to low compressional deformation occurs in the easternmost foreland basin and eastern Betic Cordillera. The displacement increases substantially southwards and westwards in relation to present-day extensional deformation. Major active discontinuities correspond to the NW-SE normal fault zones, which dip westwards; they are located in Almeria-Tabernas; Balanegra, and western Sierra de Gador; whereas the Padul fault zone located west of Sierra Nevada extends northwards to the Granada Basin. NW-SE extensional faults are also observed to the north, in the Baza Basin. Moreover, the activity of dextral faults along the Sorbas-Tabernas-Alpujarras-Guajares band, generally considered as a transfer fault zone, is evidenced by the displacement data. These results come to demonstrate the low activity or inactivity of the large northern E-W oriented folds of the central and eastern Internal Zone, such as the Sierra de Los Filabres antiform. They also point to the possible residual activity of the northern part of the NE-SW Sierra Nevada antiform, where the maximum relief of the Cordillera is found. Altogether, our data support a heterogeneous present-day westward extension that affects the upper crust of the Betic Cordillera and increases towards the thinned continental crust of the Alboran Sea and towards the west, which is compatible with roll-back subduction along

  2. Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.

    PubMed

    Sunden, Fanny; Peck, Ariana; Salzman, Julia; Ressl, Susanne; Herschlag, Daniel

    2015-01-01

    Enzymes enable life by accelerating reaction rates to biological timescales. Conventional studies have focused on identifying the residues that have a direct involvement in an enzymatic reaction, but these so-called 'catalytic residues' are embedded in extensive interaction networks. Although fundamental to our understanding of enzyme function, evolution, and engineering, the properties of these networks have yet to be quantitatively and systematically explored. We dissected an interaction network of five residues in the active site of Escherichia coli alkaline phosphatase. Analysis of the complex catalytic interdependence of specific residues identified three energetically independent but structurally interconnected functional units with distinct modes of cooperativity. From an evolutionary perspective, this network is orders of magnitude more probable to arise than a fully cooperative network. From a functional perspective, new catalytic insights emerge. Further, such comprehensive energetic characterization will be necessary to benchmark the algorithms required to rationally engineer highly efficient enzymes. PMID:25902402

  3. Nuclear Energy Gradients for Internally Contracted Complete Active Space Second-Order Perturbation Theory: Multistate Extensions.

    PubMed

    Vlaisavljevich, Bess; Shiozaki, Toru

    2016-08-01

    We report the development of the theory and computer program for analytical nuclear energy gradients for (extended) multistate complete active space perturbation theory (CASPT2) with full internal contraction. The vertical shifts are also considered in this work. This is an extension of the fully internally contracted CASPT2 nuclear gradient program recently developed for a state-specific variant by us [MacLeod and Shiozaki, J. Chem. Phys. 2015, 142, 051103]; in this extension, the so-called λ equation is solved to account for the variation of the multistate CASPT2 energies with respect to the change in the amplitudes obtained in the preceding state-specific CASPT2 calculations, and the Z vector equations are modified accordingly. The program is parallelized using the MPI3 remote memory access protocol that allows us to perform efficient one-sided communication. The optimized geometries of the ground and excited states of a copper corrole and benzophenone are presented as numerical examples. The code is publicly available under the GNU General Public License. PMID:27388038

  4. Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity

    NASA Astrophysics Data System (ADS)

    Markovitz, Craig D.; Hogan, Patrick S.; Wesen, Kyle A.; Lim, Hubert H.

    2015-04-01

    Objective. The corticofugal system can alter coding along the ascending sensory pathway. Within the auditory system, electrical stimulation of the auditory cortex (AC) paired with a pure tone can cause egocentric shifts in the tuning of auditory neurons, making them more sensitive to the pure tone frequency. Since tinnitus has been linked with hyperactivity across auditory neurons, we sought to develop a new neuromodulation approach that could suppress a wide range of neurons rather than enhance specific frequency-tuned neurons. Approach. We performed experiments in the guinea pig to assess the effects of cortical stimulation paired with broadband noise (PN-Stim) on ascending auditory activity within the central nucleus of the inferior colliculus (CNIC), a widely studied region for AC stimulation paradigms. Main results. All eight stimulated AC subregions induced extensive suppression of activity across the CNIC that was not possible with noise stimulation alone. This suppression built up over time and remained after the PN-Stim paradigm. Significance. We propose that the corticofugal system is designed to decrease the brain’s input gain to irrelevant stimuli and PN-Stim is able to artificially amplify this effect to suppress neural firing across the auditory system. The PN-Stim concept may have potential for treating tinnitus and other neurological disorders.

  5. Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity

    PubMed Central

    Markovitz, Craig D.; Hogan, Patrick S.; Wesen, Kyle A.; Lim, Hubert H.

    2015-01-01

    Objective The corticofugal system can alter coding along the ascending sensory pathway. Within the auditory system, electrical stimulation of the auditory cortex (AC) paired with a pure tone can cause egocentric shifts in the tuning of auditory neurons, making them more sensitive to the pure tone frequency. Since tinnitus has been linked with hyperactivity across auditory neurons, we sought to develop a new neuromodulation approach that could suppress a wide range of neurons rather than enhance specific frequency-tuned neurons. Approach We performed experiments in the guinea pig to assess the effects of cortical stimulation paired with broadband noise (PN-Stim) on ascending auditory activity within the central nucleus of the inferior colliculus (CNIC), a widely studied region for AC stimulation paradigms. Main results All eight stimulated AC regions induced extensive suppression of activity across the CNIC that was not possible with noise stimulation alone. This suppression built up over time and remained after the PN-Stim paradigm. Significance We propose that the corticofugal system is designed to decrease the brain’s input gain to irrelevant stimuli and PN-Stim is able to artificially amplify this effect to suppress neural firing across the auditory system. The PN-Stim concept may have potential for treating tinnitus and other neurological disorders. PMID:25686163

  6. C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism.

    PubMed

    Dutta, Sruti; Choudhury, Debi; Dattagupta, Jiban K; Biswas, Sampa

    2011-09-01

    The amino acid sequence of ervatamin-C, a thermostable cysteine protease from a tropical plant, revealed an additional 24-amino-acid extension at its C-terminus (CT). The role of this extension peptide in zymogen activation, catalytic activity, folding and stability of the protease is reported. For this study, we expressed two recombinant forms of the protease in Escherichia coli, one retaining the CT-extension and the other with it truncated. The enzyme with the extension shows autocatalytic zymogen activation at a higher pH of 8.0, whereas deletion of the extension results in a more active form of the enzyme. This CT-extension was not found to be cleaved during autocatalysis or by limited proteolysis by different external proteases. Molecular modeling and simulation studies revealed that the CT-extension blocks some of the substrate-binding unprimed subsites including the specificity-determining subsite (S2) of the enzyme and thereby partially occludes accessibility of the substrates to the active site, which also corroborates the experimental observations. The CT-extension in the model structure shows tight packing with the catalytic domain of the enzyme, mediated by strong hydrophobic and H-bond interactions, thus restricting accessibility of its cleavage sites to the protease itself or to the external proteases. Kinetic stability analyses (T(50) and t(1/2) ) and refolding experiments show similar thermal stability and refolding efficiency for both forms. These data suggest that the CT-extension has an inhibitory role in the proteolytic activity of ervatamin-C but does not have a major role either in stabilizing the enzyme or in its folding mechanism. PMID:21707922

  7. Extensive hydrothermal activity in the NE Lau basin revealed by ROV dives

    NASA Astrophysics Data System (ADS)

    Embley, R. W.; Resing, J. A.; Tebo, B.; Baker, E. T.; Butterfield, D. A.; Chadwick, B.; Davis, R.; de Ronde, C. E. J.; Lilley, M. D.; Lupton, J. E.; Merle, S. G.; Rubin, K. H.; Shank, T. M.; Walker, S. L.; Arculus, R. J.; Bobbitt, A. M.; Buck, N. J.; Caratori Tontini, F.; Crowhurst, P. V.; Mitchell, E.; Olson, E. J.; Ratmeyer, V.; Richards, S.; Roe, K. K.; Kenner-Chavis, P.; Martinez-Lyons, A.; Sheehan, C.; Brian, R.

    2014-12-01

    Dives with the QUEST 4000 ROV (Remotely Operated Vehicle) in September 2012 discovered nine hydrothermal sites in the arc and rear-arc region of the NE Lau Basin in 1150 m to 2630 m depth. These sites, originally detected by water column and seafloor surveys conducted in 2008-2011, include: (1) a paired sulfur-rich/black smoker field on the summit of a tectonically deformed magmatic arc volcano (Niua), (2) fracture-controlled black smoker venting on several small en echelon seamounts (north Matas) that lie between the magmatic arc and the backarc spreading center and (3) a magmatic degassing site on the summit of a dacite cone within a large (~12 km diameter) caldera volcano (Niuatahi). Dives at West Mata Seamount, which was undergoing strombolian volcanic activity and effusive rift-zone eruptions from 2008 to 2010, revealed a dormant volcanic phase in September 2012, with continued low-temperature diffuse venting. The high-temperature venting is likely driven by magmatic heat indicative of underlying partial melt zones and/or melt pockets distributed through the region. The occurrence of the youngest known boninite eruptions on the Mata volcanoes is consistent with subduction fluid flux melting extending into the rear-arc zone. Extension related to the transition from subduction to strike-slip motion of the northern Tonga Arc over the active Subduction-Transform Edge Propagator (STEP) fault probably contributes to the enhanced volcanism/hydrothermal activity in the NE Lau Basin. Chemosynthetic ecosystems at these sites range from mostly motile, lower diversity ecosystems at the eruptive/magmatically-degassing sites to higher diversity ecosystems with less mobile faunal components at the black-smoker systems. The wide range of fluid chemistry, water depth and geologic settings of the hydrothermal systems in this area provides an intriguing template to study the interaction of hydrothermal fluid chemistry, chemosynthetic habitats and their geologic underpinning

  8. Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

    PubMed

    Horita, Yasuhiro; Takii, Takemasa; Yagi, Tetsuya; Ogawa, Kenji; Fujiwara, Nagatoshi; Inagaki, Emi; Kremer, Laurent; Sato, Yasuo; Kuroishi, Ryuji; Lee, Yoosa; Makino, Toshiaki; Mizukami, Hajime; Hasegawa, Tomohiro; Yamamoto, Ryuji; Onozaki, Kikuo

    2012-08-01

    The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB. PMID:22615274

  9. Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates

    PubMed Central

    Horita, Yasuhiro; Yagi, Tetsuya; Ogawa, Kenji; Fujiwara, Nagatoshi; Inagaki, Emi; Kremer, Laurent; Sato, Yasuo; Kuroishi, Ryuji; Lee, YooSa; Makino, Toshiaki; Mizukami, Hajime; Hasegawa, Tomohiro; Yamamoto, Ryuji; Onozaki, Kikuo

    2012-01-01

    The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB. PMID:22615274

  10. 77 FR 28369 - Commission Information Collection Activities (FERC-576); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... facilities as a result of a hurricane, earthquake, or other natural disaster, or terrorist activity, (2... interested in receiving automatic notification of activity in this docket or in viewing/downloading comments... disaster or terrorist activity, that creates the potential for serious delivery problems on the...

  11. Southeast Papuan crustal tectonics: Imaging extension and buoyancy of an active rift

    NASA Astrophysics Data System (ADS)

    Abers, G. A.; Eilon, Z.; Gaherty, J. B.; Jin, G.; Kim, YH.; Obrebski, M.; Dieck, C.

    2016-02-01

    Southeast Papua hosts the world's youngest ultra-high-pressure (UHP) metamorphic rocks. These rocks are found in an extensional setting in metamorphic core complexes. Competing theories of extensional shear zones or diapiric upwelling have been suggested as driving their exhumation. To test these theories, we analyze the CDPAPUA temporary array of 31 land and 8 seafloor broadband seismographs. Seismicity shows that deformation is being actively accommodated on the core complex bounding faults, offset by transfer structures in a manner consistent with overall north-south extension rather than radial deformation. Rayleigh wave dispersion curves are jointly inverted with receiver functions for crustal velocity structure. They show crustal thinning beneath the core complexes of 30-50% and very low shear velocities at all depths beneath the core complexes. On the rift flanks velocities resemble those of normal continents and increase steadily with depth. There is no evidence for velocity inversions that would indicate that a major density inversion exists to drive crustal diapirs. Also, low-density melt seems minor within the crust. Together with the extension patterns apparent in seismicity, these data favor an extensional origin for the core complexes and limit the role of diapirism as a secondary exhumation mechanism, although deeper mantle diapirs may be undetected. A small number of intermediate-depth earthquakes, up to 120 km deep, are identified for the first time just northeast of the D'Entrecasteaux Islands. They occur at depths similar to those recorded by UHP rocks and similar temperatures, indicating that the modern seismicity occurs at the setting that generates UHP metamorphism.

  12. Extension joints: a tool to infer the active stress field orientation (case study from southern Italy)

    NASA Astrophysics Data System (ADS)

    De Guidi, Giorgio; Caputo, Riccardo; Scudero, Salvatore; Perdicaro, Vincenzo

    2013-04-01

    An intense tectonic activity in eastern Sicily and southern Calabria is well documented by the differential uplift of Late Quaternary coastlines and by the record of the strong historical earthquakes. The extensional belt that crosses this area is dominated by a well established WNW-ESE-oriented extensional direction. However, this area is largely lacking of any structural analysis able to define the tectonics at a more local scale. In the attempt to fill this gap of knowledge, we carried out a systematic analysis of extension joint sets. In fact, the systematic field collection of these extensional features, coupled with an appropriate inversion technique, allows to determine the characteristic of the causative tectonic stress field. Joints are defined as outcrop-scale mechanical discontinuities showing no evidence of shear motion and being originated as purely extensional fractures. Such tectonic features are one of the most common deformational structures in every tectonic environment and particularly abundant in the study area. A particular arrangement of joints, called "fracture grid-lock system", and defined as an orthogonal joint system where mutual abutting and crosscutting relationships characterize two geologically coeval joint sets, allow to infer the direction and the magnitude of the tectonic stress field. We performed the analyses of joints only on Pleistocene deposits of Eastern Sicily and Southern Calabria. Moreover we investigated only calcarenite sediments and cemented deposits, avoiding claysh and loose matrix-supported clastic sediments where the deformation is generally accomodated in a distributed way through the relative motion between the single particles. In the selection of the sites, we also took into account the possibility to clearly observe the geometric relationships among the joints. For this reason we chose curvilinear road cuts or cliffs, wide coastal erosional surfaces and quarries. The numerical inversions show a similar stress

  13. Towards Modeling a Collaborative Environment for Extension of Professional Active Life

    NASA Astrophysics Data System (ADS)

    Afsarmanesh, Hamideh; Camarinha-Matos, Luis

    Progress on computer networks is offering new conditions for individuals to remain active after their retirement. Furthermore, the scarcity of human resources and the increasing percentage of elder professionals in Europe have catalyzed the formation of a new type of collaborative community referred to as community of active senior professionals (CASP). These new networks aim to support retired professionals with their participation in socio-economic activities and thus remaining professionally active. As such, identification of their specificities as well as developing a descriptive model of CASPs is challenging. This paper characterizes the CASP environments and performs a first attempt towards identifying and modeling their constituent elements.

  14. The Scholarly Activity Predictor Model among Counseling Psychology Doctoral Students: A Modification and Extension

    ERIC Educational Resources Information Center

    Huber, Daniel M.

    2010-01-01

    The purpose of the current study was to help understand scholarly activity better among counseling psychology doctoral students. Two new variables were added to the previously created predictor model of scholarly activity: advisory working alliance and research competence. Three path analytic models were designed in the current study: (1) a…

  15. 75 FR 18545 - MMS Information Collection Activity: 1010-0067, Oil and Gas Well-Completion Operations, Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... Minerals Management Service MMS Information Collection Activity: 1010-0067, Oil and Gas Well- Completion Operations, Extension of a Collection; Comment Request AGENCY: Minerals Management Service (MMS), Interior... submit to the Office of Management and Budget (OMB) for review and approval. The information...

  16. Read Alouds and Beyond: The Effects of Read Aloud Extension Activities on Vocabulary in Head Start Classrooms

    ERIC Educational Resources Information Center

    Silverman, Rebecca; Crandell, Jennifer DiBara; Carlis, Lydia

    2013-01-01

    A study was conducted in 26 Head Start classrooms with 264 children to compare the effect of a read aloud plus extension activities intervention over a control group to the effect of a read aloud only intervention over a control group on preschool children's vocabulary. Children were assessed before and after the intervention on target vocabulary…

  17. 76 FR 72210 - Agency Information Collection Activities: Extension of an Information Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... Immigration and Customs Enforcement (ICE), is submitting the following information collection request for... United States Immigration and Customs Enforcement, Department of Homeland Security, and sent...

  18. 77 FR 66862 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... Immigration and Customs Enforcement (ICE), will submit the following information collection request for review... Immigration and Customs Enforcement, Department of Homeland Security, and sent via electronic mail...

  19. 75 FR 53322 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities... Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), will submit the following... United States Immigration and Customs Enforcement, Department of Homeland Security, and sent...

  20. 75 FR 24721 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities... Homeland Security, U.S. Immigration and Customs Enforcement (USICE), has submitted the following...), Joseph M. Gerhart, Chief, Records Management Branch, U.S. Immigration and Customs Enforcement, 500...

  1. 77 FR 33478 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... 1653- 0019). The Department of Homeland Security, U.S. Immigration and Customs Enforcement (ICE), is... should be addressed to OMB Desk Officer, for United States Immigration and Customs...

  2. 77 FR 77069 - Commission Information Collection Activities (FERC-730); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    .../2006), published: 71 FR 43294. Actual transmission investment for the most recent calendar year, and... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Commission Information Collection Activities (FERC-730); Comment...

  3. 76 FR 57081 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments... directed to Mr. Gregory E. Scarbro, Unit Chief, Federal Bureau of Investigation, CJIS Division, Module E-3..., Federal Bureau of Investigation, Department of Justice. (4) Affected public who will......

  4. 77 FR 56863 - Agency Information Collection Activities: Proposed Collection, Comments Requested Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments.../collection: Federal Bureau of Investigation Bioterrorism Preparedness Act: Entity/Individual Information. (3... collection: Forms FD-961; Criminal Justice Information Services Division, Federal Bureau of......

  5. 77 FR 56861 - Agency Information Collection Activities: Proposed Collection, Comments Requested Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments.../collection: Federal Bureau of Investigation Bioterrorism Preparedness Act: Entity/Individual Information. (3... collection: Forms FD-961; Criminal Justice Information Services Division, Federal Bureau of......

  6. 77 FR 41801 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments..., Federal Bureau of Investigation, Criminal Justice Information Services Division, (CJIS), Module E-3, 1000.... (2) The title of the form/collection: Federal Bureau of Investigation Bioterrorism......

  7. 78 FR 63247 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments... October 31 ACTION: 30-day Notice. Department of Justice, Federal Bureau of Investigation, Criminal Justice...-711; Criminal Justice Information Services Division, Federal Bureau of Investigation,......

  8. 76 FR 72977 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments..., Federal Bureau of Investigation, Criminal Justice Information Services Division (CJIS), will be submitting... directed to Mr. Gregory E. Scarbro, Unit Chief, Federal Bureau of Investigation, CJIS......

  9. 78 FR 48720 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... Federal Bureau of Investigation Agency Information Collection Activities; Proposed Collection; Comments... October 31 ACTION: 60-Day notice. The Department of Justice, Federal Bureau of Investigation, Criminal..., Federal Bureau of Investigation, Criminal Justice Information Services (CJIS) Division,......

  10. 77 FR 4833 - Agency Information Collection Activities; Proposed Collection, Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Federal Bureau of Investigation Agency Information Collection Activities; Proposed Collection, Comments..., Federal Bureau of Investigation, Criminal Justice Information Services Division (CJIS) will be submitting... directed to Mr. Gregory E. Scarbro, Unit Chief, Federal Bureau of Investigation, CJIS......

  11. 77 FR 56862 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments.../collection: Federal Bureau of Investigation Bioterrorism Preparedness Act: Entity/Individual Information. (3... collection: Forms FD-961; Criminal Justice Information Services Division, Federal Bureau of......

  12. 78 FR 48719 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... Federal Bureau of Investigation Agency Information Collection Activities; Proposed Collection; Comments... Enforcement ACTION: 60-Day notice. The Department of Justice, Federal Bureau of Investigation, Criminal..., Federal Bureau of Investigation, Criminal Justice Information Services (CJIS) Division,......

  13. 78 FR 63247 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments... Enforcement ACTION: 30-day Notice. The Department of Justice, Federal Bureau of Investigation, Criminal... collection: Form 1-725; Criminal Justice Information Services Division, Federal Bureau of......

  14. 77 FR 76015 - Commission Information Collection Activities (FERC-607); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... (EPAct 2005) modified FERC's role in order to better coordinate the activities of the separate agencies with varying responsibilities over proposed natural gas projects. Section 313 of EPAct 2005 \\1\\...

  15. Active oblique extension in the central Apennines (Italy): evidence from the Fucino region

    NASA Astrophysics Data System (ADS)

    Piccardi, Luigi; Gaudemer, Yves; Tapponnier, Paul; Boccaletti, Mario

    1999-11-01

    The Fucino Basin is a flat Quaternary depression within the central Apennines. It is surrounded by active normal faults with small oblique-slip components. Surface faulting was observed along the east side of the basin during the Ms=7.0 Avezzano earthquake of 1915. In order to understand the kinematics of recent strain better and to assess the seismic hazard of this region, we carried out a detailed geomorphic and structural study of the faults around the basin. Fault scarp heights were accurately measured with total station profiles, and vertical slip rates were estimated assuming slope offsets to post-date the end of periglacial abrasion (14+/-4 kyr BP). To the north, the most prominent fault, the Magnola fault, appears to have an average postglacial throw rate of 0.7+/-0.3 mm yr-1 and, together with the Velino fault, to be capable of generating earthquakes of maximum magnitudes of 6.9-7.3 with recurrence intervals of 1000-3000 yr. East of the basin, the Serrone, Parasano and Ventrino faults form a right-stepping horsetail of the Giovenco fault. Current vertical slip rates on the three former faults appear to be between 0.5 and 1.4, 0.5 and 1.0, and 0.3 and 1.1 mm yr-1, respectively. Infrequent maximum-magnitude earthquakes on them may also exceed 7, particularly in the case of coupled rupture, with loosely constrained recurrence intervals (up to several thousand years). The right-lateral slip components implied by the most recent slickensides and by geomorphic offsets on the NW-SE-trending normal faults of the area suggest that the blocks they bound rotate counterclockwise, consistent with oblique left slip on the NNW-SSE-trending Giovenco and Ovindoli faults to the east. Sinistral shear parallel to the latter faults, the maximum relief across the Magnola fault, and the postglacial slope offsets measured suggest that the extension rate across the central Apennines might be of the order of 6+/-3 mm yr-1 in a N20 deg+/-10 degE direction, more northerly than

  16. Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis.

    PubMed

    Kohansal-Nodehi, Mahdokht; Chua, John Je; Urlaub, Henning; Jahn, Reinhard; Czernik, Dominika

    2016-01-01

    Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles. While many of the proteins governing these processes are known, their regulation is only beginning to be understood. Here we have applied quantitative phosphoproteomics to identify changes in phosphorylation status of presynaptic proteins in resting and stimulated nerve terminals isolated from the brains of Wistar rats. Using rigorous quantification, we identified 252 phosphosites that are either up- or downregulated upon triggering calcium-dependent exocytosis. Particularly pronounced were regulated changes of phosphosites within protein constituents of the presynaptic active zone, including bassoon, piccolo, and RIM1. Additionally, we have mapped kinases and phosphatases that are activated upon stimulation. Overall, our study provides a snapshot of phosphorylation changes associated with presynaptic activity and provides a foundation for further functional analysis of key phosphosites involved in presynaptic plasticity. PMID:27115346

  17. The Effect of Amorphization Conditions on the Measured Activation of Source Drain Extension Implants

    SciTech Connect

    England, Jonathan; Kontos, Alexander; Renau, Anthony; Gwilliam, Russell; Smith, Andrew; Knights, Andrew; Jain, Amitabh

    2008-11-03

    Un-patterned wafers were processed using low-dose Indium or medium-dose Germanium pre-amorphization implants (PAI) followed by p-type dopant implants of BF{sub 2} or carborane (CBH). The wafers were then annealed by RTA (spike), laser anneal (LSA) or combination of LSA and spike. Active dopant distributions calculated from SIMS and sheet resistance measurements compared favorably with those determined by differential Hall, which is a challenging technique for shallow profiles. The trends in B diffusion behavior and activation are discussed in relation to the different implant damage budgets, damage evolution during the anneals and presence of fluorine. In particular, for low thermal budget LSA only anneals, CBH implants appear to give higher activation than BF{sub 2} due to the absence of fluorine.

  18. 77 FR 31033 - Agency Information Collection Activities: Form I-589, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... published in the Federal Register on March 19, 2012, at 77 FR 16047, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-589... Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

  19. 75 FR 65022 - Agency Information Collection Activities: Form I-698, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    .... The information collection was previously published in the Federal Register on June 23, 2010, at 75 FR... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-698... Resident; OMB Control No. 1615-0035. The Department of Homeland Security, U.S. Citizenship and...

  20. 77 FR 34398 - Agency Information Collection Activities: Form N-565, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ..., 2012, at 77 FR 18255, allowing for a 60-day public comment period. USCIS did not receive any comments... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-565... Immigration Services (USCIS) will be submitting the following information collection request to the Office...

  1. 77 FR 3485 - Agency Information Collection Activities: Form I-129F, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Federal Register on October 28, 2011, at 76 FR 66944, allowing for a 60-day public comment period. USCIS... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-129F... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following...

  2. 77 FR 27474 - Agency Information Collection Activities: Form I-687; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-687...-687. The Department Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS) has...-687; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will be asked...

  3. 77 FR 3484 - Agency Information Collection Activities: Form I-914, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Federal Register on October 28, 2011, at 76 FR 66944, allowing for a 60-day public comment period. USCIS... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-914... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following...

  4. 77 FR 16047 - Agency Information Collection Activities: Form I-589; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-19

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-589.... 1615-0067. The Department Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be...: Form I-589; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will be asked...

  5. 76 FR 31971 - Agency Information Collection Activities: Form I-212; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... on March 16, 2011, at 76 FR 14419, allowing for a 60-day public comment period. USCIS received no... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-212.... Citizenship and Immigration Services (USCIS) will be submitting the following information collection...

  6. 75 FR 65022 - Agency Information Collection Activities: Form I-751, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... collection was previously published in the Federal Register on June 30, 2010, at 75 FR 37821, allowing for a... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-751.... 1615- 0038. The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS)...

  7. 77 FR 34053 - Agency Information Collection Activities: Form I-590, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... published in the Federal Register on March 12, 2012, at 77 FR 14535, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-590... of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

  8. 77 FR 27473 - Agency Information Collection Activities: Form I-924; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-924... Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS) will be submitted... sponsoring the collection: Form I-924; U.S. Citizenship and Immigration Services. (4) Affected public...

  9. 77 FR 3486 - Agency Information Collection Activities: Form I-539, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... previously published in the Federal Register on October 28, 2011, at 76 FR 66946, allowing for a 60-day... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-539... Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

  10. 75 FR 52539 - Agency Information Collection Activities: Form I-777, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... information collection was previously published in the Federal Register on June 9, 2010, at 75 FR 32799... asked or required to respond, as well as a brief abstract: Primary: Individuals or Households. Form I... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form...

  11. 76 FR 11805 - Agency Information Collection Activities: Form I-134, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... published in the Federal Register on December 14, 2010, at 75 FR 77891, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-134... Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

  12. 77 FR 42322 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities... Homeland Security, U.S. Immigration and Customs Enforcement (ICE), will submit the following information..., Chief, Records Management, U.S. Immigration and Customs Enforcement, 500 12th Street SW., Stop...

  13. 75 FR 71451 - Agency Information Collection Activities: Form N-470, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... information collection was previously published in the Federal Register on August 18, 2010, at 75 FR 51096... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-470... Control No. 1615-0056. The Department of Homeland Security, U.S. Citizenship and Immigration...

  14. 77 FR 11148 - Agency Information Collection Activities: Extension, Without Change, of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...-0026. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (ICE), will submit... Homeland Security (DHS), John Ramsay, Program (Forms) Manager, U.S. Immigration and Customs...

  15. 76 FR 79204 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-21

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... ] The Department of Homeland Security, U.S. Immigration and Customs Enforcement (ICE), will submit the... Security (DHS), John Ramsay, Program Manager, U.S. Immigration and Customs Enforcement, 500 12th Street...

  16. 75 FR 24720 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... Immigration and Customs Enforcement (USICE), has submitted the following information collection request for... Management Branch, U.S. Immigration and Customs Enforcement, 500 12th Street, SW., Room 3138, Washington,...

  17. 78 FR 23577 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities... Information Collection for Review; File No. I- 352, Immigration Bond; OMB Control No. 1653-0022. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (ICE), will submit the...

  18. 75 FR 24721 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... The Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), will be... Homeland Security (DHS), Joseph M. Gerhart, Chief, Records Management Branch, U.S. Immigration and...

  19. 77 FR 37063 - Agency Information Collection Activities: Extension, Without Change, of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...-0026). The Department of Homeland Security, U.S. Immigration and Customs Enforcement (ICE), will submit... Homeland Security (DHS), John Ramsay, Program (Forms) Manager, U.S. Immigration and Customs...

  20. 76 FR 66944 - Agency Information Collection Activities: Form I-129F; Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... SECURITY Citizenship and Immigration Services Agency Information Collection Activities: Form I-129F.... The Department of Homeland Security, U.S. Citizenship and Immigration Services will be submitting the... Department of Homeland Security sponsoring the collection: Form I-129F, U.S. Citizenship and...

  1. 75 FR 12249 - Agency Information Collection Activities: Form I-134, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... the Federal Register on November 12, 2009, at 74 FR 58302 allowing for a 60-day public comment period... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-134... Homeland Security, U.S. Citizenship and Immigration Services (USCIS) has submitted the...

  2. 75 FR 16158 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...-0026. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), has... should be addressed to OMB Desk Officer, for U. S. Immigration and Customs Enforcement, Department...

  3. 75 FR 65500 - Agency Information Collection Activities: Form I-360, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... information collection was previously published in the Federal Register on June 30, 2010, at 75 FR 37820... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-360... Control No. 1615-0020. The Department of Homeland Security, U.S. Citizenship and Immigration...

  4. 75 FR 2881 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...-0026. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), has... of Homeland Security (DHS), Joseph M. Gerhart, Chief, Records Management Branch, U.S. Immigration...

  5. 78 FR 44141 - Agency Information Collection Activities: Affidavit of Support, Form I-134; Extension, Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Affidavit of.... SUMMARY: The Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS... accuracy of the agency's estimate of the burden of the proposed collection of information, including...

  6. The Improvement of Thinking Skills in Young Children Using Computer Activities: A Replication and Extension.

    ERIC Educational Resources Information Center

    Riding, R. J.; Powell, S. D.

    1986-01-01

    Replicates and extends Riding and Powells' study of four-year-olds' problem-solving abilities using computer activities. Achieves similar results, namely significantly greater improvement between the pretest and posttest scores for the treatment group. Suggests that computers could aid worthwhile improvement in young children's thinking…

  7. 75 FR 51096 - Agency Information Collection Activities: Form N-400; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-400... Collection Under Review; Form N- 400, Application for Naturalization; OMB Control No. 1615-0052. The... 60 day period, USCIS will be evaluating whether to revise the Form N-400. Should USCIS decide...

  8. 75 FR 13776 - Agency Information Collection Activities: Form N-300; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-300... Collection Under Review; Form N- 300, Application to File Declaration of Intention; OMB Control No. 1615-0078... this 60-day period, USCIS will be evaluating whether to revise the Form N-300. Should USCIS decide...

  9. 75 FR 51094 - Agency Information Collection Activities: Form N-600; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-600... Collection under Review; Form N- 600, Application for Certificate of Citizenship; OMB Control No. 1615- 0057..., 2010. During this 60 day period, USCIS will be evaluating whether to revise the Form N-600....

  10. 75 FR 70278 - Agency Information Collection Activities: Form N-600, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-600... Information Collection Under Review: Form N- 600, Application for Certificate of Citizenship; OMB Control No..., and the applicable component of the Department of Homeland Security sponsoring the collection: Form...

  11. 76 FR 69275 - Agency Information Collection Activities: Form N-400, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-400... Information Collection Under Review: Form N- 400, Application for Naturalization; OMB Control No. 1615-0052... the Department of Homeland Security sponsoring the collection: Form N-400. U.S. Citizenship...

  12. 75 FR 70277 - Agency Information Collection Activities: Form N-400, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-400... Information Collection Under Review: Form N- 400, Application for Naturalization; OMB Control No. 1615-0052... applicable component of the Department of Homeland Security sponsoring the collection: Form N-400;...

  13. 75 FR 21013 - Agency Information Collection Activities: Form N-644; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Collection Under Review; Form N- 644, Application for Posthumous Citizenship; OMB Control No. 1615-0059. The..., USCIS will be evaluating whether to revise the Form N-644. Should USCIS decide to revise Form N-644...

  14. 76 FR 21913 - Agency Information Collection Activities: Form N-644; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Collection Under Review: Form N- 644, Application for Posthumous Citizenship; OMB Control No. 1615-0059. The..., USCIS will be evaluating whether to revise the Form N-644. Should USCIS decide to revise Form N-644...

  15. 76 FR 27078 - Agency Information Collection Activities: Form N-426, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-426... Information Collection Under Review: Form N- 426, Request for Certification of Military or Naval Service; OMB... until July 11, 2011. During this 60-day period, USCIS will be evaluating whether to revise the Form...

  16. 75 FR 41216 - Agency Information Collection Activities: Form N-644, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Information Collection Under Review: Form N- 644, Application for Posthumous Citizenship; OMB Control No. 1615... N-644; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will be asked...

  17. 77 FR 24507 - Agency Information Collection Activities: Form N-25, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-25... Information Collection Under Review: Form N- 25, Request for Verification of Naturalization. The Department of... component of the Department of Homeland Security sponsoring the collection: Form N-25. U.S. Citizenship...

  18. 75 FR 5098 - Agency Information Collection Activities: Form N-565, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-565... information collection under review: Form N- 565, Application for Replacement Naturalization/Citizenship... Homeland Security sponsoring the collection: Form N-565; U.S. Citizenship and Immigration Services...

  19. 75 FR 80835 - Agency Information Collection Activities: Form N-565; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-565... Collection Under Review; Form N- 565, Application for Replacement Naturalization/Citizenship Document; OMB... N-565. Should USCIS decide to revise Form N-565 we will advise the public when we publish the...

  20. 76 FR 39415 - Agency Information Collection Activities: Form N-644, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Information Collection Under Review: Form N- 644, Application for Posthumous Citizenship; OMB Control No. 1615... Homeland Security sponsoring the collection: Form N-644; U.S. Citizenship and Immigration Services...

  1. 75 FR 51095 - Agency Information Collection Activities: Form N-336; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-336... Collection under Review; Form N- 336, Request for Hearing on a Decision in Naturalization Proceedings Under... the Form N-336. Should USCIS decide to revise Form N-336 we will advise the public when we publish...

  2. 77 FR 18255 - Agency Information Collection Activities: Form N-565; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-565... collection under review; Form N- 565, Application for Replacement Naturalization/Citizenship Document; OMB... until May 29, 2012. During this 60 day period, USCIS will be evaluating whether to revise the Form...

  3. 75 FR 70277 - Agency Information Collection Activities: Form N-336, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-336... Information Collection Under Review: Form N- 336, Request for Hearing on a Decision in Naturalization... collection: Form N-336; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will...

  4. 75 FR 51096 - Agency Information Collection Activities: Form N-470; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-470... Collection Under Review; Form N- 470, Application To Preserve Residence for Naturalization; OMB Control No... until October 18, 2010. During this 60-day period, USCIS will be evaluating whether to revise the Form...

  5. 75 FR 32801 - Agency Information Collection Activities: Form I-865; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-865... Collection Under Review: Form I- 865, Sponsor's Notice of Change of Address; OMB Control Number 1615- 0076. The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) has...

  6. 78 FR 45919 - Commission Information Collection Activities (FERC Form 80); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... the Federal Register (78 FR 28820, 5/16/2013) requesting public comments. FERC received no comments on... Energy Regulatory Commission Commission Information Collection Activities (FERC Form 80); Comment Request... the requirements of the Paperwork Reduction Act of 1995, 44 U.S.C. 3507(a)(1)(D), the Federal...

  7. 76 FR 65740 - Extension of Agency Information Collection Activity Under OMB Review: Employment Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ... soliciting comments, of the following collection of information on August 10, 2011, 76 FR 49503. The... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND..., aircraft piracy, and terrorist activities. Number of Respondents: 1,337. Estimated Annual Burden Hours:...

  8. 76 FR 28444 - Agency Information Collection Activities: Form G-884, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-884... information collection under review: Form G- 884, Request for the Return of Original Documents; OMB Control No... July 18, 2011. During this 60-day period, USCIS will be evaluating whether to revise the Form...

  9. 75 FR 23785 - Agency Information Collection Activities: Form G-639; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-639... Collection Under Review; Form G- 639, Freedom of Information/Privacy Act Request; OMB Control No. 1615- 0102... this 60 day period, USCIS will be evaluating whether to revise the Form G-639. Should USCIS decide...

  10. 76 FR 11807 - Agency Information Collection Activities: Form G-646, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... December 15, 2010, at 75 FR 78263, allowing for a 60-day public comment period. USCIS did not receive any... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-646... Information Collection Under Review: Form G- 646, Sworn Statement of Refugee Applying for Admission to...

  11. 76 FR 11806 - Agency Information Collection Activities: Form G-1145, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... information collection was previously published in the Federal Register on December 14, 2010, at 75 FR 77890... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-1145... Information Collection Under Review: Form G- 1145, E-Notification of Application/Petition Acceptance;...

  12. 76 FR 48874 - Agency Information Collection Activities: Form G-884, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... the Federal Register on March 17, 2011, at 76 FR 28444, allowing for a 60- day public comment period... SECURITY Citizenship and Immigration Services Agency Information Collection Activities: Form G-884... Collection Under Review: Form G- 884, Request for the Return of Original Document(s). The Department...

  13. 75 FR 5097 - Agency Information Collection Activities: Form G-646, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... 74 FR 58037, allowing for a 60-day public comment period. USCIS did not receive any comments for this... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-646... Information Collection Under Review: Form G- 646, Sworn Statement of Refugee Applying for Admission to...

  14. 77 FR 33760 - Agency Information Collection Activities: Form G-646, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-07

    ... collection was previously published in the Federal Register on March 9, 2012, at 77 FR 14407, allowing for a... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-646... Information Collection Under Review: Form G- 646, Sworn Statement of Refugee Applying for Admission to...

  15. 75 FR 47822 - Agency Information Collection Activities: Form G-639, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ... collection was previously published in the Federal Register on May 4, 2010, at 75 FR 23785, allowing for a 60... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-639... Information Collection Under Review: Form G- 639, Freedom of Information/Privacy Act Request; OMB Control...

  16. 76 FR 24908 - Agency Information Collection Activities: Form G-639; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-639... Collection Under Review; Form G- 639, Freedom of Information/Privacy Act Request; OMB Control No. 1615- 0102.... During this 60 day period, USCIS will be evaluating whether to revise the Form G-639. Should USCIS...

  17. 77 FR 38307 - Agency Information Collection Activities: Refugee/Asylee Relative Petition, Extension, Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Refugee/Asylee... Information Collection Under Review: Form I- 730, Refugee/Asylee Relative Petition; OMB Control No. 1615-0037.... (2) Title of the Form/Collection: Refugee/Asylee Relative Petition. (3) Agency form number, if...

  18. Effect of Behavioral Activation Treatment on Chronic Fibromyalgia Pain: Replication and Extension

    ERIC Educational Resources Information Center

    Lundervold, Duane A.; Talley, Chris; Buermann, Michael

    2008-01-01

    A multiple-baseline-across two behavior sets and positions (reclined, upright) was used to experimentally examine the effect of Behavioral Activation Treatment for Pain (BAT-P) on pain-related behavior of a 44-year-old woman with a 22-year history of fibromyalgia (FM). BAT-P, based on the matching law, is comprised of Behavioral Relaxation…

  19. 76 FR 71607 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments.... Gregory E. Scarbro, Unit Chief, Federal Bureau of Investigation, CJIS Division, Module E-3, 1000 Custer... collection: Form Number 1-725; Sponsor: Criminal Justice Information Services Division, Federal Bureau......

  20. 77 FR 70746 - Commission Information Collection Activities (FERC-592); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-27

    ... Provider; and Marketing Affiliates of Interstate Pipelines. DATES: Comments on the collection of... Marketing Affiliates of Interstate Pipelines. OMB Control No.: 1 902-0157. Type of Request: Three-year... the pipeline's transportation, sales, and storage activities for its marketing affiliate to...

  1. 76 FR 11807 - Agency Information Collection Activities: Form N-565, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... 75 FR 80835, allowing for a 60-day public comment period. USCIS did not receive any comments for this... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-565... Document; OMB Control No. 1615-0091. * * * * * The Department of Homeland Security, U.S. Citizenship...

  2. 75 FR 51094 - Agency Information Collection Activities: Form I-363, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    .... The information collection was previously published in the Federal Register on June 23, 2010, at 75 FR... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-363... Amerasian; OMB Control No. 1615-0022. The Department of Homeland Security, U.S. Citizenship and...

  3. 76 FR 21912 - Agency Information Collection Activities: Form I-363; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-363... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following information... the Department of Homeland Security sponsoring the collection: Form I-363, U.S. Citizenship...

  4. 75 FR 35822 - Agency Information Collection Activities: Form I-363; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-363... Control No. 1615-0022. The Department of Homeland Security, U.S. Citizenship and Immigration Services... Homeland Security sponsoring the collection: Form I-363; U.S. Citizenship and Immigration Services...

  5. Extensive and Diverse Submarine Volcanism and Hydrothermal Activity in the NE Lau Basin

    NASA Astrophysics Data System (ADS)

    Embley, R. W.; Merle, S. G.; Lupton, J. E.; Resing, J.; Baker, E. T.; Lilley, M. D.; Arculus, R. J.; Crowhurst, P. V.

    2009-12-01

    The northeast Lau basin, the NE “corner” of the Tonga subduction zone, has an unusual concentration of young submarine volcanism and hydrothermal activity. The area is bounded on the west by overlapping spreading centers opening at rates up to 120 mm/yr, on the north by the E-W trending Tonga trench and on the east by the Tofua arc front. From the south, the Fonualei rift spreading center (FRSC) overlaps with the southern rift of The Mangatolo triple junction spreading center (MTJSC). The northern arm of the MTJSC overlaps with the northeast Lau spreading center (NELSC). Surveys of the area with an EM300 sonar system in November 2008 show high backscatter over the 10-20 km wide neovolcanic zones of the FRSC, MTJSC and NELSC. High backscatter is also associated with: (1) a 10-km diameter, hydrothermally active, volcanic caldera/cone (Volcano “O”) lying between the NELSC and the northern Tofua arc front; (2) a rift zone extending north from volcano “O” and intersecting the NELSC near the Tonga trench; and (3) a series of volcanoes constructed along SW-NE trending crustal tears in the northernmost backarc near the east-west portion of the Tonga Trench. Two eruptions were detected in November 2008 during hydrothermal plume surveys of the area. Subsequent dives with the remotely operated vehicle Jason 2 in May 2009 revealed that the southern NELSC eruption was a short-lived, primarily effusive eruption. The second eruption was detected on the summit of the largest SW-NE trending volcano (West Mata) and was ongoing when Jason 2 arrived on site more than 6 months later. It was producing both pillow lavas and abundant volcaniclastic debris streams that have a characteristic appearance on the sonar backscatter map. There is also an unusual series of lava flows emanating from ridges and scarps between Volcano “O” and West Mata. These flows contain drained-out lava ponds up to 2 km in diameter. The apparent high level of volcanic activity in the NE Lau basin

  6. Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    PubMed Central

    Kohansal-Nodehi, Mahdokht; Chua, John JE; Urlaub, Henning; Jahn, Reinhard; Czernik, Dominika

    2016-01-01

    Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles. While many of the proteins governing these processes are known, their regulation is only beginning to be understood. Here we have applied quantitative phosphoproteomics to identify changes in phosphorylation status of presynaptic proteins in resting and stimulated nerve terminals isolated from the brains of Wistar rats. Using rigorous quantification, we identified 252 phosphosites that are either up- or downregulated upon triggering calcium-dependent exocytosis. Particularly pronounced were regulated changes of phosphosites within protein constituents of the presynaptic active zone, including bassoon, piccolo, and RIM1. Additionally, we have mapped kinases and phosphatases that are activated upon stimulation. Overall, our study provides a snapshot of phosphorylation changes associated with presynaptic activity and provides a foundation for further functional analysis of key phosphosites involved in presynaptic plasticity. DOI: http://dx.doi.org/10.7554/eLife.14530.001 PMID:27115346

  7. Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

    PubMed

    Thomas, Anna C; Zeng, Zhiqiang; Rivière, Jean-Baptiste; O'Shaughnessy, Ryan; Al-Olabi, Lara; St-Onge, Judith; Atherton, David J; Aubert, Hélène; Bagazgoitia, Lorea; Barbarot, Sébastien; Bourrat, Emmanuelle; Chiaverini, Christine; Chong, W Kling; Duffourd, Yannis; Glover, Mary; Groesser, Leopold; Hadj-Rabia, Smail; Hamm, Henning; Happle, Rudolf; Mushtaq, Imran; Lacour, Jean-Philippe; Waelchli, Regula; Wobser, Marion; Vabres, Pierre; Patton, E Elizabeth; Kinsler, Veronica A

    2016-04-01

    Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were detected at very low levels in affected tissues but were undetectable in the blood, indicating that these conditions are postzygotic mosaic disorders. In vitro expression of mutant GNA11(R183C) and GNA11(Q209L) in human cell lines demonstrated activation of the downstream p38 MAPK signaling pathway and the p38, JNK, and ERK pathways, respectively. Transgenic mosaic zebrafish models expressing mutant GNA11(R183C) under promoter mitfa developed extensive dermal melanocytosis recapitulating the human phenotype. Phakomatosis pigmentovascularis and extensive dermal melanocytosis are therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albright and Sturge-Weber syndromes. These findings will allow accurate clinical and molecular diagnosis of this subset of common birthmarks, thereby identifying infants at risk for serious complications, and provide novel therapeutic opportunities. PMID:26778290

  8. Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis

    PubMed Central

    Thomas, Anna C.; Zeng, Zhiqiang; Rivière, Jean-Baptiste; O’Shaughnessy, Ryan; Al-Olabi, Lara; St.-Onge, Judith; Atherton, David J.; Aubert, Hélène; Bagazgoitia, Lorea; Barbarot, Sébastien; Bourrat, Emmanuelle; Chiaverini, Christine; Chong, W. Kling; Duffourd, Yannis; Glover, Mary; Groesser, Leopold; Hadj-Rabia, Smail; Hamm, Henning; Happle, Rudolf; Mushtaq, Imran; Lacour, Jean-Philippe; Waelchli, Regula; Wobser, Marion; Vabres, Pierre; Patton, E. Elizabeth; Kinsler, Veronica A.

    2016-01-01

    Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were detected at very low levels in affected tissues but were undetectable in the blood, indicating that these conditions are postzygotic mosaic disorders. In vitro expression of mutant GNA11R183C and GNA11Q209L in human cell lines demonstrated activation of the downstream p38 MAPK signaling pathway and the p38, JNK, and ERK pathways, respectively. Transgenic mosaic zebrafish models expressing mutant GNA11R183C under promoter mitfa developed extensive dermal melanocytosis recapitulating the human phenotype. Phakomatosis pigmentovascularis and extensive dermal melanocytosis are therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albright and Sturge-Weber syndromes. These findings will allow accurate clinical and molecular diagnosis of this subset of common birthmarks, thereby identifying infants at risk for serious complications, and provide novel therapeutic opportunities. PMID:26778290

  9. Extensive Reading in the EFL Classroom: Benefits of a Face-to-Face Collaboration Activity

    ERIC Educational Resources Information Center

    Kirchhoff, Cheryl

    2015-01-01

    Extensive reading is an approach to language education that has shown great promise for foreign language learners to acquire language; however, implementation reveals difficulty in maintaining student motivation to read over long periods of time. This study investigates students' experience of face-to-face talk about books in an extensive reading…

  10. 77 FR 6136 - Agency Information Collection Activities: Application for Extension of Bond for Temporary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Extension of Bond for Temporary Importation AGENCY: U.S. Customs and Border Protection (CBP), Department of... requirement concerning the Application for Extension of Bond for Temporary Importation (CBP Form 3173). This...: Direct all written comments to U.S. Customs and Border Protection, Attn: Tracey Denning, Regulations...

  11. 77 FR 21578 - Agency Information Collection Activities: Application for Extension of Bond for Temporary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... information collection was previously published in the Federal Register (77 FR 6136) on February 7, 2012... Extension of Bond for Temporary Importation AGENCY: U.S. Customs and Border Protection, Department of... review and approval in accordance with the Paperwork Reduction Act: Application for Extension of Bond...

  12. 76 FR 34217 - Commission Information Collection Activities, Proposed Collections; Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... OMB approve these information collections with a three-year extension of the expiration dates, with no... below to the Office of Management and Budget (OMB) for review and an extension of the expiration date... structure, FERC requires that the applicant submit a notice of change within 30 days from the date of...

  13. Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53*

    PubMed Central

    DeHart, Caroline J.; Chahal, Jasdave S.; Flint, S. J.; Perlman, David H.

    2014-01-01

    The p53 tumor suppressor protein accumulates to very high concentrations in normal human fibroblasts infected by adenovirus type 5 mutants that cannot direct assembly of the viral E1B 55-kDa protein-containing E3 ubiquitin ligase that targets p53 for degradation. Despite high concentrations of nuclear p53, the p53 transcriptional program is not induced in these infected cells. We exploited this system to examine select post-translational modifications (PTMs) present on a transcriptionally inert population of endogenous human p53, as well as on p53 activated in response to etoposide treatment of normal human fibroblasts. These forms of p53 were purified from whole cell lysates by means of immunoaffinity chromatography and SDS-PAGE, and peptides derived from them were subjected to nano-ultra-high-performance LC-MS and MS/MS analyses on a high-resolution accurate-mass MS platform (data available via ProteomeXchange, PXD000464). We identified an unexpectedly large number of PTMs, comprising phosphorylation of Ser and Thr residues, methylation of Arg residues, and acetylation, ubiquitinylation, and methylation of Lys residues—for example, some 150 previously undescribed modifications of p53 isolated from infected cells. These modifications were distributed across all functional domains of both forms of the endogenous human p53 protein, as well as those of an orthologous population of p53 isolated from COS-1 cells. Despite the differences in activity, including greater in vitro sequence-specific DNA binding activity exhibited by p53 isolated from etoposide-treated cells, few differences were observed in the location, nature, or relative frequencies of PTMs on the two populations of human p53. Indeed, the wealth of PTMs that we have identified is consistent with a far greater degree of complex, combinatorial regulation of p53 by PTM than previously anticipated. PMID:24056736

  14. Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling.

    PubMed

    Guo, Na; Liu, Zuojia; Zhao, Wenjing; Wang, Erkang; Wang, Jin

    2016-01-01

    Pancreatic cancer has been found with abnormal expression or mutation in Ras proteins. Oncogenic Ras activation exploits their extensive signaling reach to affect multiple cellular processes, in which the mitogen-activated protein kinase (MAPK) signaling exerts important roles in tumorigenesis. Therapies targeted Ras are thus of major benefit for pancreatic cancer. Although small molecule APY606 has been successfully picked out by virtual drug screening based on Ras target receptor, its in-depth mechanism remains to be elucidated. We herein assessed the antitumor activity of APY606 against human pancreatic cancer Capan-1 and SW1990 cell lines and explored the effect of Ras-MAPK and apoptosis-related signaling pathway on the activity of APY606. APY606 treatment resulted in a dose- and time-dependent inhibition of cancer cell viability. Additionally, APY606 exhibited strong antitumor activity, as evidenced not only by reduction in tumor cell invasion, migration and mitochondrial membrane potential but also by alteration in several apoptotic indexes. Furthermore, APY606 treatment directly inhibited Ras-GTP and the downstream activation of MAPK, which resulted in the down-regulation of anti-apoptotic protein Bcl-2, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (Bax, cytosolic Cytochrome c and Caspase 3) and of cyclin-dependent kinase 2 and Cyclin A, E. These data suggest that impairing Ras-MAPK signaling is a novel mechanism of action for APY606 during therapeutic intervention in pancreatic cancer. PMID:27223122

  15. Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling

    PubMed Central

    Guo, Na; Liu, Zuojia; Zhao, Wenjing; Wang, Erkang; Wang, Jin

    2016-01-01

    Pancreatic cancer has been found with abnormal expression or mutation in Ras proteins. Oncogenic Ras activation exploits their extensive signaling reach to affect multiple cellular processes, in which the mitogen-activated protein kinase (MAPK) signaling exerts important roles in tumorigenesis. Therapies targeted Ras are thus of major benefit for pancreatic cancer. Although small molecule APY606 has been successfully picked out by virtual drug screening based on Ras target receptor, its in-depth mechanism remains to be elucidated. We herein assessed the antitumor activity of APY606 against human pancreatic cancer Capan-1 and SW1990 cell lines and explored the effect of Ras-MAPK and apoptosis-related signaling pathway on the activity of APY606. APY606 treatment resulted in a dose- and time-dependent inhibition of cancer cell viability. Additionally, APY606 exhibited strong antitumor activity, as evidenced not only by reduction in tumor cell invasion, migration and mitochondrial membrane potential but also by alteration in several apoptotic indexes. Furthermore, APY606 treatment directly inhibited Ras-GTP and the downstream activation of MAPK, which resulted in the down-regulation of anti-apoptotic protein Bcl-2, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (Bax, cytosolic Cytochrome c and Caspase 3) and of cyclin-dependent kinase 2 and Cyclin A, E. These data suggest that impairing Ras-MAPK signaling is a novel mechanism of action for APY606 during therapeutic intervention in pancreatic cancer. PMID:27223122

  16. 75 FR 6392 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without... Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the Office...

  17. 75 FR 6391 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  18. 76 FR 4347 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  19. 75 FR 6391 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without... Equal Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the...

  20. 75 FR 63180 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  1. 75 FR 63179 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the Office...

  2. 75 FR 63179 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Equal Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the...

  3. 75 FR 63180 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency Extension Without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  4. 75 FR 18832 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  5. 75 FR 40829 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--emergency extension without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  6. 76 FR 3629 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Equal Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the...

  7. 75 FR 18833 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without... Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the Office...

  8. 75 FR 40829 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--emergency extension without... Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the Office...

  9. 75 FR 31787 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--emergency extension without change: ADEA waivers. SUMMARY: In accordance with the Paperwork Reduction Act, the Equal...

  10. 76 FR 3628 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  11. 75 FR 18833 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  12. 75 FR 40828 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--emergency extension without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  13. 75 FR 40830 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--emergency extension without... Equal Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the...

  14. 76 FR 3628 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without... Employment Opportunity Commission ] (EEOC or Commission) announces that it submitted to the Office...

  15. 75 FR 52540 - Agency Information Collection Activities: File Number OMB 25; Extension of an Existing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... Information Collection Under Review: OMB 25, Special Immigrant Visas for Fourth Preference Employment-Based...: Extension of a currently approved collection. (2) Title of the Form/Collection: Special Immigrant Visas...

  16. 75 FR 6392 - Ageny Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without... Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it...

  17. 75 FR 47311 - Extension of Agency Information Collection Activity Under OMB Review: Aviation Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... OMB Review: Aviation Security Infrastructure Fee Records Retention AGENCY: Transportation Security... retention of certain information necessary for TSA to help set the Aviation Security Infrastructure Fee... Title: Aviation Security Infrastructure Fee Records Retention. Type of Request: Extension of a...

  18. Comprehensive program and plan for federal energy education, extension, and information activities: Fiscal Year 1981. Fifth report to congress

    SciTech Connect

    Not Available

    1981-12-01

    The activities conducted solely in Fiscal Year (FY) 1981 in the areas of Federal energy education, extension service, and information dissemination are reported. The broad purpose of the FY 1981 activities addressed has been to inform governmental and private sectors about the methods and technologies to conserve energy and to utilize renewable energy sources. With the increase in awareness on the part of energy users and decisionmakers, as well as additional information sources available from the private sector, the emphasis of the various Federal energy information activities is being focused on reporting results of Federal programs. The course of activities related to conservation and renewable energy information has been one of consolidation, both in terms of programmatic substance and methods. The practical impetus has been the redirection of Federal progrms and related budgetary revisions for FY 1981 and FY 1982. Further, products conveying information on conservation and renewable energy technologies have been examined extensively, pursuant to the Administration's directive in April 1981 on elimination of wasteful spending on periodicals, audiovisuals and similar materials. Efforts in coordination of conservation and renewable energy information activities of the Department of Energy (DOE) as well as other Federal agencies have adjusted to timetables for review and redirection of programs initially planned for FY 1981. Mechanisms to coordinate existing Federal energy information activities employed in previous fiscal years were continued in FY 1981 to the extent applicable under current Administration policy and the above-noted circumstances of redirection. Coordinating actions requiring convening of groups were held in abeyance pending resolution of programmatic issues.

  19. NASA Common Research Model Test Envelope Extension With Active Sting Damping at NTF

    NASA Technical Reports Server (NTRS)

    Rivers, Melissa B.; Balakrishna, S.

    2014-01-01

    The NASA Common Research Model (CRM) high Reynolds number transonic wind tunnel testing program was established to generate an experimental database for applied Computational Fluid Dynamics (CFD) validation studies. During transonic wind tunnel tests, the CRM encounters large sting vibrations when the angle of attack approaches the second pitching moment break, which can sometimes become divergent. CRM transonic test data analysis suggests that sting divergent oscillations are related to negative net sting damping episodes associated with flow separation instability. The National Transonic Facility (NTF) has been addressing remedies to extend polar testing up to and beyond the second pitching moment break point of the test articles using an active piezoceramic damper system for both ambient and cryogenic temperatures. This paper reviews CRM test results to gain understanding of sting dynamics with a simple model describing the mechanics of a sting-model system and presents the performance of the damper under cryogenic conditions.

  20. 78 FR 26618 - Collection of Information; Proposed Extension of Approval; Comment Request-Follow-Up Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ...As required by the Paperwork Reduction Act of 1995 (PRA) (44 U.S.C. Chapter 35), the Consumer Product Safety Commission (CPSC or Commission) requests comments on a proposed extension of approval of a collection of information from persons who have been involved in or have witnessed incidents associated with consumer products. The Commission will consider all comments received in response to......

  1. 77 FR 22333 - Agency Information Collection Activities: USCIS Case Status Online, Extension of a Currently...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... Federal Register on January 30, 2012, at 77 FR 4574, allowing for a 60- day public comment period. USCIS... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND... Status Online, Extension of a Currently Approved Information Collection; Comment Request ACTION:...

  2. 77 FR 4574 - Agency Information Collection Activities: USCIS Case Status Online; Extension of an Existing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND... Status Online; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review: USCIS Case Status Online. The Department of Homeland Security (DHS),...

  3. 77 FR 71018 - Agency Information Collection Activities; Extension of a Currently Approved Collection; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... of a Currently Approved Collection; Comment Request: National Youth Gang Survey AGENCY: Office of... Collection: Extension of a currently approved collection. 2. Title of the Form/Collection: National Youth... agencies. Other: None. Abstract: This collection will gather information related to youth and...

  4. 76 FR 35023 - Agency Information Collection Activities: Proposed Collection; Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Requested; Extension of a Currently Approved Collection With Changes; State Criminal Alien Assistance.../collection: State Criminal Alien Assistance Program. (3) The agency form number, if any, and the applicable...(b) as amended in 1996, BJA administers the State Criminal Alien Assistance Program (SCAAP) with...

  5. 77 FR 31432 - Agency Information Collection; Activity Under OMB Review; Report of Extension of Credit to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Notice with a 60-day comment period was published on March 19, 2012 (77 FR 16116). The agency did not...; Report of Extension of Credit to Political Candidates AGENCY: Research & Innovative Technology... with the Paperwork Reduction Act of 1995, Public Law 104-13, (44 U.S.C. 3501 et seq.) this...

  6. 78 FR 42802 - Agency Information Collection Activities; Proposed Collection; Comments Requested Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... Extension of a Currently Approved Collection: Capital Punishment Report of Inmates Under Sentence of Death...: Capital Punishment Report of Inmates Under Sentence of Death. (3) Agency form number, if any, and the... Inmates Under Sentence of Death; NPS-8A Update Report of Inmates Under Sentence of Death; NPS-8B Status...

  7. 78 FR 58348 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ...; Extension of a Currently Approved Collection: Capital Punishment Report of Inmates Under Sentence of Death...: Capital Punishment Report of Inmates under Sentence of Death. (3) Agency form number, if any, and the... Inmates under Sentence of Death; NPS-8A Update Report of Inmate under Sentence of Death; NPS-8B Status...

  8. 75 FR 37815 - Agency Information Collection Activities: Two-Year Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ...: Two-Year Extension of an Existing Information Collection; Proposed Collection: Comment Request In... and training programs. The reporting system has two parts: Part I of the performance report is... multiple race combinations for two or more races. And second, a new measure will be added to...

  9. 76 FR 19791 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... additional information, see the related notice published in the Federal Register on November 10, 2010 (75 FR...; Extension of Employee Retirement Income Security Act Class Exemption 81-8 for Investment of Plan Assets in...) titled, ``Employee Retirement Income Security Act Class Exemption 81-8 for Investment of Plan Assets...

  10. 76 FR 19790 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... published in the Federal Register on November 10, 2010 (75 FR 69131). Interested parties are encouraged to...; Extension of Employee Retirement Income Security Act Class Exemption 77-4 for Certain Transactions Between...) titled, ``Employee Retirement Income Security Act Class Exemption 77-4 for Certain Transactions...

  11. 77 FR 4054 - Extension of Agency Information Collection Activity Under OMB Review: TSA Customer Comment Card

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-26

    ...This notice announces that the Transportation Security Administration (TSA) has forwarded the Information Collection Request (ICR), Office of Management and Budget (OMB) control number 1652-0030, abstracted below, to OMB for review and approval of an extension of the currently-approved collection under the Paperwork Reduction Act (PRA). The ICR describes the nature of the information......

  12. 77 FR 8278 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ...: Extension of a Currently Approved Collection; Victims of Crime Act, Crime Victim Assistance Grant Program... (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) will be submitting the... approved collection. (2) Title of the Form/Collection: Victims of Crime Act, Crime Victim Assistance...

  13. 76 FR 77258 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ...: Extension of a Currently Approved Collection; Victim of Crime Act, Crime Victim Assistance Grant Program... (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) will be submitting the... information, please contact DeLano Foster (202) 616-3612, Office for Victims of Crime, Office of...

  14. 77 FR 50718 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ...: Extension of a Currently Approved Collection; Victims of Crime Act, Crime Victim Assistance Grant Program... Justice (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) will be submitting the... collection. (2) Title of the Form/Collection: Victims of Crime Act, Crime Victim Assistance Grant...

  15. 77 FR 36009 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ...: Extension of a Currently Approved Collection; Victims of Crime Act, Crime Victim Assistance Grant Program... (OJP), Office for Victims of Crime (OVC) will be submitting the following information collection...Lano Foster 202-616-3612, Office for Victims of Crime, Office of Justice Programs, U.S. Department...

  16. 77 FR 11147 - Agency Information Collection Activities: Extension, Without Change, of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... information technology, e.g., permitting electronic submission of responses. Overview of this information collection: (1) Type of Information Collection: Extension, without change, of a previously approved collection. The type of information collection as previously reported in the 60-day Federal Register...

  17. 76 FR 67758 - Extension of Agency Information Collection Activity Under OMB Review: Imposition and Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... OMB Review: Imposition and Collection of Passenger Civil Aviation Security Service Fees AGENCY... an accounting system to account for the passenger civil aviation security service fees collected and... Passenger Civil Aviation Security Service Fees. Type of Request: Extension of a currently...

  18. The Cooperative Extension System's Use of USDA's Online Food and Physical Activity Tracker-Supertracker

    ERIC Educational Resources Information Center

    Hongu, Nobuko; Martinez, Cathy L.; Billias, Natalia N.; Wyatt, Melissa A.; Turner, Rachel J.; Manore, Melinda M.

    2014-01-01

    Nutrition professionals within the Cooperative Extension system use the USDA's interactive online tool SuperTracker, which is designed to help individuals track diet and physical activity (PA) to apply healthy eating patterns and improve PA. An investigation of all 50 states' Extension websites and interviews of Extension educators…

  19. Evidence of parasexual activity in "asexual amoebae" Cochliopodium spp. (Amoebozoa): extensive cellular and nuclear fusion.

    PubMed

    Tekle, Yonas I; Anderson, O Roger; Lecky, Ariel F

    2014-09-01

    The majority of microbial eukaryotes have long been considered asexual, though new evidence indicates sex, or sexual-like (parasexual) behaviors that deviate from the usual union of two gametes, among other variant aspects. Over a dozen amoebozoans are implicated to have sexual stages. However, the exact mechanism by which sex occurs in these lineages remains elusive. This is mainly due to the diverse quality and cryptic nature of their life cycle. In this study we present evidence of some previously unreported aspects of the life cycle of an amoeba, Cochliopodium, that undergoes unusual intraspecific interactions using light microscopy and immunocytochemistry. Similar to other amoebozoans, Cochliopodium, is considered asexual with no published reports of sex or parasexuality. We also investigated environmental conditions that govern the observed intraspecific interactions. Both light microscopic and immunocytochemistry evidence demonstrates Cochliopodium undergoes cellular fusion (plasmogamy) and nuclear fusion (karyogamy). Large plasmodia eventually undergo karyogamy and contain large fused, polyploid, nuclei. These are observed to fragment, subsequently, by karyotomy (nuclear fission) and cytoplasmic fission to yield uninucleated amoebae. This process could lead to a non-meiotic, parasexual exchange of chromosomes in Cochliopodium. These findings strongly suggest that Cochliopodium is involved in parasexual activity and should no longer be considered strictly asexual. PMID:25168314

  20. Within- and between-session reliability of the maximal voluntary knee extension torque and activation.

    PubMed

    Park, Jihong; Hopkins, J Ty

    2013-01-01

    A ratio between the torque generated by maximal voluntary isometric contraction (MVIC) and exogenous electrical stimulus, central activation ratio (CAR), has been widely used to assess quadriceps function. To date, no data exist regarding between-session reliability of this measurement. Thirteen neurologically sound volunteers underwent three testing sessions (three trials per session) with 48 hours between-session. Subjects performed MVICs of the quadriceps with the knee locked at 90° flexion and the hip at 85°. Once the MVIC reached a plateau, an electrical stimulation from superimposed burst technique (SIB: 125 V with peak output current 450 mA) was manually delivered and transmitted directly to the quadriceps via stimulating electrodes. CAR was calculated by using the following equation: CAR = MVIC torque/MVIC + SIB torque. Intraclass correlation coefficients (ICC) were calculated within- (ICC((2,1))) and between-session (ICC((2,k))) for MVIC torques and CAR values. Our data show that quadriceps MVIC and CAR are very reliable both within- (ICC((2,1)) = 0.99 for MVIC; 0.94 for CAR) and between-measurement sessions (ICC((2,k)) = 0.92 for MVIC; 0.86 for CAR) in healthy young adults. For clinical research, more data of the patients with pathological conditions are required to ensure reproducibility of calculation of CAR. PMID:23009562

  1. Non-extensivity and long-range correlations in the earthquake activity at the West Corinth rift (Greece)

    NASA Astrophysics Data System (ADS)

    Michas, G.; Vallianatos, F.; Sammonds, P.

    2013-09-01

    In the present work the statistical properties of the earthquake activity in a highly seismic region, the West Corinth rift (Central Greece), are being studied by means of generalized statistical physics. By using a dataset that covers the period 2001-2008, we investigate the earthquake energy distribution and the distribution of the time intervals (interevent times) between the successive events. As has been reported previously, these distributions exhibit complex statistical properties and fractality. By using detrended fluctuation analysis (DFA), a well-established method for detection of long-range correlations in non-stationary signals, it is shown that long-range correlations are also present in the earthquake activity. The existence of these properties motivates us to use non-extensive statistical physics (NESP) to investigate the statistical properties of the frequency-magnitude and the interevent time distributions, along with other well-known relations in seismology, such as the gamma distribution for interevent times. The results of the analysis indicate that the statistical properties of the earthquake activity can be successfully reproduced by means of NESP and that the earthquake activity at the West Corinth rift is correlated at all-time scales.

  2. Feature-specific imaging: Extensions to adaptive object recognition and active illumination based scene reconstruction

    NASA Astrophysics Data System (ADS)

    Baheti, Pawan K.

    Computational imaging (CI) systems are hybrid imagers in which the optical and post-processing sub-systems are jointly optimized to maximize the task-specific performance. In this dissertation we consider a form of CI system that measures the linear projections (i.e., features) of the scene optically, and it is commonly referred to as feature-specific imaging (FSI). Most of the previous work on FSI has been concerned with image reconstruction. Previous FSI techniques have also been non-adaptive and restricted to the use of ambient illumination. We consider two novel extensions of the FSI system in this work. We first present an adaptive feature-specific imaging (AFSI) system and consider its application to a face-recognition task. The proposed system makes use of previous measurements to adapt the projection basis at each step. We present both statistical and information-theoretic adaptation mechanisms for the AFSI system. The sequential hypothesis testing framework is used to determine the number of measurements required for achieving a specified misclassification probability. We demonstrate that AFSI system requires significantly fewer measurements than static-FSI (SFSI) and conventional imaging at low signal-to-noise ratio (SNR). We also show a trade-off, in terms of average detection time, between measurement SNR and adaptation advantage. Experimental results validating the AFSI system are presented. Next we present a FSI system based on the use of structured light. Feature measurements are obtained by projecting spatially structured illumination onto an object and collecting all of the reflected light onto a single photodetector. We refer to this system as feature-specific structured imaging (FSSI). Principal component features are used to define the illumination patterns. The optimal LMMSE operator is used to generate object estimates from the measurements. We demonstrate that this new imaging approach reduces imager complexity and provides improved image

  3. Long-Term Community Dynamics of Small Landbirds with and Without Exposure to Extensive Disturbance from Military Training Activities

    NASA Astrophysics Data System (ADS)

    Rivers, James W.; Gipson, Philip S.; Althoff, Donald P.; Pontius, Jeffrey S.

    2010-02-01

    Military training activities are known to impact individual species, yet our understanding of how such activities influence animal communities is limited. In this study, we used long-term data in a case study approach to examine the extent to which the local small landbird community differed between a site in northeast Kansas that experienced intensive disturbance from military training activities (Ft. Riley Military Installation) and a similar, nearby site that experienced minimal human disturbance (Konza Prairie Biological Station). In addition, we characterized how the regional pool of potential colonizers influenced local community dynamics using Breeding Bird Survey data. From 1991 to 2001, most species of small terrestrial landbirds (73%) recorded during breeding surveys were found at both sites and the mean annual richness at Ft. Riley (39.0 ± 2.86 [SD]) was very similar to that of Konza Prairie (39.4 ± 2.01). Richness was maintained at relatively constant levels despite compositional changes because colonizations compensated local extinctions at both sites. These dynamics were driven primarily by woodland species that exhibited stochastic losses and gains and were present at a low local and regional abundance. Our results suggest that military training activities may mimic natural disturbances for some species in this area because the small landbird community did not differ markedly between sites with and sites without extensive human disturbance. Although our results suggest that military training is not associated with large changes in the avian community, additional studies are needed to determine if this pattern is found in other ecological communities.

  4. Range of motion and leg rotation affect electromyography activation levels of the superficial quadriceps muscles during leg extension.

    PubMed

    Signorile, Joseph F; Lew, Karen M; Stoutenberg, Mark; Pluchino, Alessandra; Lewis, John E; Gao, Jinrun

    2014-09-01

    Leg extension (LE) is commonly used to strengthen the quadriceps muscles during training and rehabilitation. This study examined the effects of limb position (POS) and range of motion (ROM) on quadriceps electromyography (EMG) during 8 repetitions (REP) of LE. Twenty-four participants performed 8 LE REP at their 8 repetition maximum with lower limbs medially rotated (TI), laterally rotated (TO), and neutral (NEU). Each REP EMG was averaged over the first, middle, and final 0.524 rad ROM. For vastus medialis oblique (VMO), a REP × ROM interaction was detected (p < 0.02). The middle 0.524 rad produced significantly higher EMG than the initial 0.524 rad for REP 6-8 and the final 0.524 rad produced higher EMG than the initial 0.524 rad for REP 1, 2, 3, 4, 6, and 8 (p ≤ 0.05). For rectus femoris (RF), EMG activity increased across REP with TO generating the greatest activity (p < 0.001). For vastus lateralis (VL), EMG increased across REP (p < 0.001) with NEU and TO EMG increasing linearly throughout ROM and TI activity greatest during the middle 0.524 rad. We conclude that to target the VMO, the optimal ROM is the final 1.047 rad regardless of POS, while maximum EMG for the RF is generated using TO regardless of ROM. In contrast, the VL is maximally activated using TI over the first 1.047 rad ROM or in NEU over the final 0.524 rad ROM. PMID:25148303

  5. Range of motion and leg rotation affect EMG activation levels of the superficial quadriceps muscles during leg extension.

    PubMed

    Signorile, Joseph F; Lew, Karen; Stoutenberg, Mark; Pluchino, Alessandra; Lewis, John E; Gao, Jinrun

    2014-06-30

    The leg extension (LE) is commonly used to strengthen the quadriceps muscles during training and rehabilitation. This study examined the effects of limb position (POS) and range of motion (ROM) on quadriceps electromyography (EMG) during 8 repetitions (REP) of LE. Twenty-four participants performed eight LE REP at their 8-repetition maximum with lower limbs medially rotated (TI), laterally rotated (TO), and neutral (NEU). Each REP EMG was averaged over the first, middle, and final 0.524 rad ROM. For vastus medialis oblique (VMO), a REP x ROM interaction was detected (p<0.02). The middle 0.524 rad produced significantly higher EMG than the initial 0.524 rad for REP 6-8 and the final 0.524 rad produced higher EMG than the initial 0.524 rad for REP 1, 2, 3, 4, 6, 8 (p<0.05). For rectus femoris (RF), EMG activity increased across REP with TO generating the greatest activity (p<0.001). For vastus lateralis (VL), EMG increased across REP (p<0.001) with NEU and TO EMG increasing linearly throughout ROM, and TI activity greatest during the middle 0.524 rad. We conclude that to target the VMO the optimal ROM is the final 1.047 rad regardless of POS, while maximum EMG for the RF is generated using TO regardless of ROM. In contrast, the VL is maximally activated using TI over the first 1.047 rad ROM or in NEU over the final 0.524 rad ROM. PMID:24983846

  6. Understanding Along-strike Variations in Extension and Magmatism in Active Rifts: Discontinuous Structure Along the Main Ethiopian Rift

    NASA Astrophysics Data System (ADS)

    Keranen, K. M.; Klemperer, S. L.

    2006-12-01

    A compilation of recent geophysical and geological data reveals a discontinuity in the structure of the Main Ethiopian Rift (MER) at ~8.5°N. Recent wide-angle seismic data (from the 2003 EAGLE project) recorded along the axis of the MER show a rapid increase of crustal thickness from c. 26 km in the NE to c. 40 km in the SW at this latitude, and receiver functions recorded on the northwestern plateau show a change in crustal thickness from over 40 km in the NE to c. 33 km in the SW. The thin crust (c. 26 km) in the NE segment of the rift is markedly thinner than the adjacent rift shoulders (over 40 km), as expected for an active rift. In contrast, the thick rift crust to the SW (c. 40 km) is apparently *thicker* than the crust of the adjacent northern rift shoulder. We consider two hypotheses to explain these observations: 1. The crust within the rift valley in the SW has been thickened by magmatic processes, i.e. a high degree of magmatism (underplating) resulting from the modest extension of unusually hot mantle has led to rift-crust thickening rather than thinning; or 2. The thick crust along the active-source profile in the SW represents pre-rift crustal thickness, which the active MER has as yet barely modified. The former hypothesis is unlikely because crustal structure in the SW appears relatively unmodified by magmatic processes, e.g. there is no observed 7.x km/s layer at the base of the crust and only very slightly elevated velocities are present in the lower or upper crust. In the latter hypothesis, extension of the MER may have hardly affected the location of the wide-angle profile SW of 8.5°N; rather, this latitude represents a discontinuity between the northern MER and a distinct rift segment south of 8.5°N. Seismic tomography from EAGLE active-source and broadband data supports this hypothesis, showing crustal and mantle segmentation (between NE and SW) at this location. Along with surface geological data, these data indicate that the northern MER

  7. Initiation of Extension in South China Continental Margin during the Active-Passive Margin Transition: Thermochronological and Kinematic Constraints

    NASA Astrophysics Data System (ADS)

    Zuo, X.; Chan, L. S.

    2015-12-01

    The South China continental margin is characterized by a widespread magmatic belt, prominent NE-striking faults and numerous rifted basins filled by Cretaceous-Eocene sediments. The geology denotes a transition from active to passive margin, which led to rapid modifications of crustal stress configuration and reactivation of older faults in this area. Our zircon fission-track data in this region show two episodes of exhumation: The first episode, occurring during 170-120Ma, affected local parts of the Nanling Range. The second episode, a more regional exhumation event, occurred during 115-70Ma, including the Yunkai Terrane and the Nanling Range. Numerical geodynamic modeling was conducted to simulate the subduction between the paleo-Pacific plate and the South China Block. The modeling results could explain the fact that exhumation of the granite-dominant Nanling Range occurred earlier than that of the gneiss-dominant Yunkai Terrane. In addition to the difference in rock types, the heat from Jurassic-Early Cretaceous magmatism in Nanling may have softened the upper crust, causing the area to exhume more readily than Yunkai. Numerical modeling results also indicate that (1) high lithospheric geothermal gradient, high slab dip angle and low convergence velocity favor the reversal of crustal stress state from compression to extension in the upper continental plate; (2) late Mesozoic magmatism in South China was probably caused by a slab roll-back; and (3) crustal extension could have occurred prior to the cessation of plate subduction. The inversion of stress regime in the continental crust from compression to crustal extension imply that the Late Cretaceous-early Paleogene red-bed basins in South China could have formed during the late stage of the subduction, accounting for the occurrence of volcanic events in some sedimentary basins. We propose that the rifting started as early as Late Cretaceous, probably before the cessation of subduction process.

  8. PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation.

    PubMed

    Lee, Hyeyoon; Lee, Seung Joon; Kim, Gun-Hwa; Yeo, Inchul; Han, Jin-Kwan

    2016-03-01

    Phospholipase D (PLD) is involved in the regulation of receptor-associated signaling, cell movement, cell adhesion and endocytosis. However, its physiological role in vertebrate development remains poorly understood. In this study, we show that PLD1 is required for the convergent extension (CE) movements during Xenopus gastrulation by activating Wnt/PCP signaling. Xenopus PLD1 protein is specifically enriched in the dorsal region of Xenopus gastrula embryo and loss or gain-of-function of PLD1 induce defects in gastrulation and CE movements. These defective phenotypes are due to impaired regulation of Wnt/PCP signaling pathway. Biochemical and imaging analysis using Xenopus tissues reveal that PLD1 is required for Fz7 receptor endocytosis upon Wnt11 stimulation. Moreover, we show that Fz7 endocytosis depends on dynamin and regulation of GAP activity of dynamin by PLD1 via its PX domain is crucial for this process. Taken together, our results suggest that PLD1 acts as a new positive mediator of Wnt/PCP signaling by promoting Wnt11-induced Fz7 endocytosis for precise regulation of Xenopus CE movements. PMID:26806705

  9. Extension of in vivo half-life of biologically active peptides via chemical conjugation to XTEN protein polymer.

    PubMed

    Podust, Vladimir N; Sim, Bee-Cheng; Kothari, Dharti; Henthorn, Lana; Gu, Chen; Wang, Chia-wei; McLaughlin, Bryant; Schellenberger, Volker

    2013-11-01

    XTEN, unstructured biodegradable proteins, have been used to extend the in vivo half-life of genetically fused therapeutic proteins and peptides. To expand the applications of XTEN technology to half-life extension of other classes of molecules, XTEN protein polymers and methods for chemical XTENylation were developed. Two XTEN precursors were engineered to contain enzymatically removable purification tags. The proteins were readily expressed in bacteria and purified to homogeneity by chromatography techniques. As proof-of-principle, GLP2-2G peptide was chemically conjugated to each of the two XTEN protein polymers using maleimide-thiol chemistry. The monodisperse nature of XTEN protein polymer enabled reaction monitoring as well as the detection of peptide modifications in the conjugated state using reverse phase-high performance liquid chromatography (RP-HPLC) and electrospray ionization mass spectrometry. The resulting GLP2-2G-XTEN conjugates were purified by preparative RP-HPLC to homogeneity. In comparison with recombinantly fused GLP2-2G-XTEN, chemically conjugated GLP2-2G-XTEN molecules exhibited comparable in vitro activity, in vitro plasma stability and pharmacokinetics in rats. These data suggest that chemical XTENylation could effectively extend the half-life of a wide spectrum of biologically active molecules, therefore broadening its applicability. PMID:24133142

  10. Initiation of extension in South China continental margin during the active-passive margin transition: kinematic and thermochronological constraints

    NASA Astrophysics Data System (ADS)

    ZUO, Xuran; CHAN, Lung

    2015-04-01

    The southern South China Block is characterized by a widespread magmatic belt, prominent NE-striking fault zones and numerous rifted basins filled by Cretaceous-Eocene sediments. The geology denotes a transition from an active to a passive margin, which led to rapid modifications of crustal stress configuration and reactivation of older faults in this area. In this study, we used zircon fission-track dating (ZFT) and numerical modeling to examine the timing and kinematics of the active-passive margin transition. Our ZFT results on granitic plutons in the SW Cathaysia Block show two episodes of exhumation of the granitic plutons. The first episode, occurring during 170 Ma - 120 Ma, affected local parts of the Nanling Range. The second episode, a more regional exhumation event, occurred during 115 Ma - 70 Ma. Numerical geodynamic modeling was conducted to simulate the subduction between the paleo-Pacific plate and the South China Block. The modeling results could explain the observation based on ZFT data that exhumation of the granite-dominant Nanling Range occurred at an earlier time than the gneiss-dominant Yunkai Terrane. In addition to the difference in geology between Yunkai and Nanling, the heating from Jurassic-Early Cretaceous magmatism in the Nanling Range may have softened the upper crust, causing the area to exhume more readily. Numerical modeling results also indicate that (1) high slab dip angle, high geothermal gradient of lithosphere and low convergence velocity favor the subduction process and the reversal of crustal stress state from compression to extension in the upper plate; (2) the late Mesozoic magmatism in South China was probably caused by a slab roll-back; and (3) crustal extension could have occurred prior to the cessation of plate subduction. The inversion of stress regime in the continental crust from compression to crustal extension has shed light on the geological condition producing the red bed basins during Late Cretaceous

  11. Extension in the Colorado Plateau/Basin and Range Transition Zone, Central Utah: An Active or Passive Process?

    NASA Astrophysics Data System (ADS)

    Hasterok, D.; Wannamaker, P. E.; Chapman, D. S.; Doerner, W.

    2007-12-01

    The Colorado Plateau-Great Basin transition zone (TZ) in central Utah is a presently extending lithospheric block composed of previously stable Proterozoic lithosphere. TZ extension may be driven by high topography resulting from overthickening during the Laramide Orogeny and passive plate boundary forces similar to the Great Basin. However, high TZ topography coupled with a thinned lithosphere may indicate dynamic mantle upwelling and active processes acting within the TZ. To investigate the active vs. passive rifting hypotheses we have collected 56 new broadband and 9 long-period MT stations to merge two existing MT lines for a combined length of 400~km (124 sites) covering the eastern Great Basin into the Colorado Plateau at a latitude of ~38.5°N. We have also collected over 300 new heat production and thermal conductivity measurements across the southwest to develop a thermal model of the eastern Basin and Range and Colorado Plateau. MT data show a semi-contiguous highly conductive body in the lower crust of the eastern Great Basin that rises to a shallow depth of <20~km beneath the TZ. This conductive layer appears to be connected to the surface by a series of symmetric rift related normal faults mapped at the surface. These normal faults may be acting as pathways for large-scale fluid connection between the upper and lower crust. MT inversion results suggest an electrical anisotropy factor >3 in the upper mantle with an enhanced conductivity in a N-S orientation that is in agreement with observations of fast seismic SKS split direction. We propose that anisotropy observations may be due to small degrees of interconnected partial melt aligned with a N-S geologic strike beneath the Basin and Range. A thermal model, combining measured thermophysical properties with existing heat flow data, MT measurements, and estimates of seismogenic depth is used to predict lithospheric thickness and mantle temperature variations along the MT profile. Lithospheric thicknesses

  12. Prostate boundary segmentation from ultrasound images using 2D active shape models: optimisation and extension to 3D.

    PubMed

    Hodge, Adam C; Fenster, Aaron; Downey, Dónal B; Ladak, Hanif M

    2006-12-01

    Boundary outlining, or segmentation, of the prostate is an important task in diagnosis and treatment planning for prostate cancer. This paper describes an algorithm based on two-dimensional (2D) active shape models (ASM) for semi-automatic segmentation of the prostate boundary from ultrasound images. Optimisation of the 2D ASM for prostatic ultrasound was done first by examining ASM construction and image search parameters. Extension of the algorithm to three-dimensional (3D) segmentation was then done using rotational-based slicing. Evaluation of the 3D segmentation algorithm used distance- and volume-based error metrics to compare algorithm generated boundary outlines to gold standard (manually generated) boundary outlines. Minimum description length landmark placement for ASM construction, and specific values for constraints and image search were found to be optimal. Evaluation of the algorithm versus gold standard boundaries found an average mean absolute distance of 1.09+/-0.49 mm, an average percent absolute volume difference of 3.28+/-3.16%, and a 5x speed increase versus manual segmentation. PMID:16930764

  13. Anti-filarial Activity of Antibiotic Therapy Is Due to Extensive Apoptosis after Wolbachia Depletion from Filarial Nematodes

    PubMed Central

    Sullivan, William; Taylor, Mark J.

    2011-01-01

    Filarial nematodes maintain a mutualistic relationship with the endosymbiont Wolbachia. Depletion of Wolbachia produces profound defects in nematode development, fertility and viability and thus has great promise as a novel approach for treating filarial diseases. However, little is known concerning the basis for this mutualistic relationship. Here we demonstrate using whole mount confocal microscopy that an immediate response to Wolbachia depletion is extensive apoptosis in the adult germline, and in the somatic cells of the embryos, microfilariae and fourth-stage larvae (L4). Surprisingly, apoptosis occurs in the majority of embryonic cells that had not been infected prior to antibiotic treatment. In addition, no apoptosis occurs in the hypodermal chords, which are populated with large numbers of Wolbachia, although disruption of the hypodermal cytoskeleton occurs following their depletion. Thus, the induction of apoptosis upon Wolbachia depletion is non-cell autonomous and suggests the involvement of factors originating from Wolbachia in the hypodermal chords. The pattern of apoptosis correlates closely with the nematode tissues and processes initially perturbed following depletion of Wolbachia, embryogenesis and long-term sterilization, which are sustained for several months until the premature death of the adult worms. Our observations provide a cellular mechanism to account for the sustained reductions in microfilarial loads and interruption of transmission that occurs prior to macrofilaricidal activity following antibiotic therapy of filarial nematodes. PMID:22072969

  14. Separate effects of moisture content and water activity on the hyphal extension of Penicillium rubens on porous media.

    PubMed

    van Laarhoven, Karel A; Huinink, Hendrik P; Segers, Frank J J; Dijksterhuis, Jan; Adan, Olaf C G

    2015-12-01

    To prevent indoor fungal growth, understanding the moisture relations of fungi is a key element. Indoor moisture is quantified by the relative humidity (RH). RH controls the water activity of the indoor materials that fungi grow on, a well-studied parameter known to limit fungal growth. RH, however, also controls the amount of water present in these materials, the moisture content. The significance of the moisture content of these materials to indoor fungal growth is currently overlooked. In the work reported here, growth experiments with the indoor fungus Penicillium rubens on gypsum substrates were performed to test whether the moisture content influences growth on porous materials. Second, we report the development of a video microscopy method that for the first time quantified hyphal growth on a porous material. It is found that a higher moisture content leads to earlier colonization and higher hyphal extension rates. This is a fundamental step in unravelling the effect of RH on indoor fungal growth. The real-time monitoring of colonization of gypsum provides a new view of growth on indoor surfaces. PMID:26248303

  15. Effects of abdominal drawing-in during prone hip extension on the muscle activities of the hamstring, gluteus maximus, and lumbar erector spinae in subjects with lumbar hyperlordosis

    PubMed Central

    Kim, Tae-Woo; Kim, Yong-Wook

    2015-01-01

    [Purpose] The purpose of this study was to compare the effects of an abdominal drawing-in maneuver (ADIM), measured using a pressure bio-feedback unit, on the activities of the hamstring, gluteus maximus, and erector spinae muscles during prone hip extension. [Subjects and Methods] Thirty healthy adult subjects (14 male, 16 female), were recruited. Subjects’ lumbar lordosis and pelvic tilt angles were measured, and based on the results, the subjects were divided into two groups: a hyperlordotic lumbar angle (HLLA) group (n=15) and a normal lordotic lumbar angle (NLLA) group (n=15). The muscle activities of the hamstring and gluteus maximus, and of the erector spinae on the right side of the body, were recorded using surface electromyography. [Results] When performing ADIM with prone hip extension, the muscle activity of the gluteus maximus of the HLLA group significantly improved compared with that the NLLA group. [Conclusion] This study demonstrated that ADIM with prone hip extension was more effective at eliciting gluteus maximus activity in the HLLA group than in the NLLA group. Therefore, ADIM with prone hip extension may be useful for increasing the gluteus maximus activity of individuals with lumbar hyperlordosis. PMID:25729173

  16. The non-catalytic N-terminal extension of formylglycine-generating enzyme is required for its biological activity and retention in the endoplasmic reticulum.

    PubMed

    Mariappan, Malaiyalam; Gande, Santosh Lakshmi; Radhakrishnan, Karthikeyan; Schmidt, Bernhard; Dierks, Thomas; von Figura, Kurt

    2008-04-25

    Formylglycine-generating enzyme (FGE) catalyzes the oxidation of a specific cysteine residue in nascent sulfatase polypeptides to formylglycine (FGly). This FGly is part of the active site of all sulfatases and is required for their catalytic activity. Here we demonstrate that residues 34-68 constitute an N-terminal extension of the FGE catalytic core that is dispensable for in vitro enzymatic activity of FGE but is required for its in vivo activity in the endoplasmic reticulum (ER), i.e. for generation of FGly residues in nascent sulfatases. In addition, this extension is needed for the retention of FGE in the ER. Fusing a KDEL retention signal to the C terminus of FGE is sufficient to mediate retention of an N-terminally truncated FGE but not sufficient to restore its biological activity. Fusion of FGE residues 1-88 to secretory proteins resulted in ER retention of the fusion protein. Moreover, when fused to the paralog of FGE (pFGE), which itself lacks FGly-generating activity, the FGE extension (residues 34-88) of this hybrid construct led to partial restoration of the biological activity of co-expressed N-terminally truncated FGE. Within the FGE N-terminal extension cysteine 52 is critical for the biological activity. We postulate that this N-terminal region of FGE mediates the interaction with an ER component to be identified and that this interaction is required for both the generation of FGly residues in nascent sulfatase polypeptides and for retention of FGE in the ER. PMID:18305113

  17. 76 FR 24910 - Agency Information Collection Activities: Forms G-325, G-325A, G-325B, and G-325C; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... FR 6629, allowing for a 60-day public comment period. USCIS did not receive any comments for this... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-325, G-325A, G- 325B, and G-325C; Extension of a Currently Approved Information Collection; Comment...

  18. 76 FR 6629 - Agency Information Collection Activities: Forms G-325, G-325A, G-325B, and G-325C; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-325, G-325A, G- 325B, and G-325C; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review; Forms 325, G-325A, G-325B, and G-325C,...

  19. Is the Modified Tardieu Scale in Semi-Standing Position Better Associated with Knee Extension and Hamstring Activity in Terminal Swing than the Supine Tardieu?

    ERIC Educational Resources Information Center

    Faber, Irene R.; Nienhuis, Bart; Rijs, Nique P. A. M.; Geurts, Alexander C. H.; Duysens, Jacques

    2008-01-01

    The aim of this study was to investigate whether the modified Tardieu scale (MTS) in a semi-standing position, used for the assessment of hamstrings spasticity, was better associated with knee extension and hamstrings activity in terminal swing than the MTS in a supine position in children with cerebral palsy (CP). Seven children diagnosed with…

  20. 75 FR 65021 - Agency Information Collection Activities: Form I-485 and Supplements A and E, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... Federal Register on June 30, 2010, at 75 FR 37820, allowing for a 60-day public comment period. USCIS did... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-485 and... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following...

  1. 77 FR 3486 - Agency Information Collection Activities: No Agency Form Number, File Number OMB 25, Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Register on October 28, 2011, at 76 FR 66945, allowing for a 60-day public comment period. USCIS did not... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: No Agency Form.... Citizenship and Immigration Services (USCIS) will be submitting the following information collection...

  2. 77 FR 23735 - Agency Information Collection Activities: Forms G-1041 and G-1041A, Extension of a Currently...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ..., 2012, at 77 FR 9259, allowing for a 60-day public comment period. USCIS did not receive any comments... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-1041... Notice of Information Collection Under Review: Forms G- 1041 and G-1041A, Genealogy Index Search...

  3. 77 FR 9259 - Agency Information Collection Activities: Forms G-1041 and G-1041A, Extension of a Currently...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-1041... Notice of Information Collection Under Review: Forms G- 1041 and G-1041A, Genealogy Index Search Request... evaluating whether to revise forms G-1041 and G-1041A. Should USCIS decide to revise forms G- 1041 and...

  4. 77 FR 27241 - Agency Information Collection Activities: Form I-918, and Supplement A and B, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-918... Status; and Supplement A and B. The Department of Homeland Security, U.S. Citizenship and Immigration... sponsoring the collection: Form I-918 and Supplements A and B; U.S. Citizenship and Immigration Services....

  5. Magma-tectonic interactions in an area of active extension; a review of recent observations, models and interpretations from Iceland

    NASA Astrophysics Data System (ADS)

    Pedersen, Rikke; Sigmundsson, Freysteinn; Drouin, Vincent; Rafn Heimisson, Elías; Parks, Michelle; Dumont, Stéphanie; Árnadóttir, Þóra; Masterlark, Timothy; Ófeigsson, Benedíkt G.; Jónsdóttir, Kristín; Hooper, Andrew

    2016-04-01

    The geological setting of Iceland provides rich opportunities of studying magma-tectonic interactions, as it constitutes Earth's largest part of the mid-oceanic ridge system exposed above sea level. A series of volcanic and seismic zones accommodate the ~2 cm/year spreading between the North-American and Eurasian plates, and the Icelandic hot-spot conveniently provides the means of exposing this oceanic crust-forming setting above sea-level. Both extinct and active plumbing system structures can be studied in Iceland, as the deeply eroded tertiary areas provide views into the structures of extinct volcanic systems, and active processes can be inferred on in the many active volcanic systems. A variety of volcanic and tectonic processes cause the Icelandic crust to deform continuously, and the availability of contemporaneous measurements of crustal deformation and seismicity provide a powerful data set, when trying to obtain insight into the processes working at depth, such as magma migration through the uppermost lithosphere, magma induced host rock deformation and volcanic eruption locations and styles. The inferences geodetic and seismic datasets allow on the active plate spreading processes and subsurface magma movements in Iceland will be reviewed, in particular in relation to the Northern Volcanic Zone (NVZ). There the three phases of a rifting cycle (rifting, post-rifting, inter-rifting) have been observed. The NVZ is an extensional rift segment, bounded to the south by the Icelandic mantle plume, and to the north by the Tjörnes transform zone. The NVZ has typically been divided into five partly overlapping en-echelon fissure swarms, each with a central main volcanic production area. Most recently, additional insight into controlling factors during active rifting has been provided by the Bárðarbunga activity in 2014-2015 that included a major rifting event, the largest effusive eruption in Iceland since 1783, and a gradual caldera collapse. It is evident

  6. Active-R filter

    DOEpatents

    Soderstrand, Michael A.

    1976-01-01

    An operational amplifier-type active filter in which the only capacitor in the circuit is the compensating capacitance of the operational amplifiers, the various feedback and coupling elements being essentially solely resistive.

  7. Extension of the stability of motions in a combustion chamber by non- linear active control based on hysteresis

    SciTech Connect

    Knoop, P.; Culick, F.E.C.; Zukoski, E.E.

    1996-07-01

    This report presents the first quantitative data establishing the details of hysteresis whose existence in dynamical behavior was reported by Sterling and Zukoski. The new idea was demonstrated that the presence of dynamical hysteresis provides opportunity for a novel strategy of active nonlinear control of unsteady motions in combustors. A figure shows the hysteresis exhibited for the amplitude of pressure oscillations as a function of equivalence ratio in a combustor having a recirculation zone, in this case a dump combustor.

  8. Understanding physical activity intentions among French Canadians with type 2 diabetes: an extension of Ajzen's theory of planned behaviour

    PubMed Central

    Boudreau, François; Godin, Gaston

    2009-01-01

    Background Regular physical activity is considered a cornerstone for managing type 2 diabetes. However, in Canada, most individuals with type 2 diabetes do not meet national physical activity recommendations. When designing a theory-based intervention, one should first determine the key determinants of physical activity for this population. Unfortunately, there is a lack of information on this aspect among adults with type 2 diabetes. The purpose of this cross-sectional study is to fill this gap using an extended version of Ajzen's Theory of Planned Behavior (TPB) as reference. Methods A total of 501 individuals with type 2 diabetes residing in the Province of Quebec (Canada) completed the study. Questionnaires were sent and returned by mail. Results Multiple hierarchical regression analyses indicated that TPB variables explained 60% of the variance in intention. The addition of other psychosocial variables in the model added 7% of the explained variance. The final model included perceived behavioral control (β = .38, p < .0001), moral norm (β = .29, p < .0001), and attitude (β = .14, p < .01). Conclusion The findings suggest that interventions aimed at individuals with type 2 diabetes should ensure that people have the necessary resources to overcome potential obstacles to behavioral performance. Interventions should also favor the development of feelings of personal responsibility to exercise and promote the advantages of exercising for individuals with type 2 diabetes. PMID:19531261

  9. Multiple episodes of hydrothermal activity and epithermal mineralization in the southwestern Nevada volcanic field and their relations to magmatic activity, volcanism and regional extension

    SciTech Connect

    Weiss, S.I.; Noble, D.C.; Jackson, M.C.

    1994-12-31

    Volcanic rocks of middle Miocene age and underlying pre-Mesozoic sedimentary rocks host widely distributed zones of hydrothermal alteration and epithermal precious metal, fluorite and mercury deposits within and peripheral to major volcanic and intrusive centers of the southwestern Nevada volcanic field (SWNVF) in southern Nevada, near the southwestern margin of the Great Basin of the western United States. Radiometric ages indicate that episodes of hydrothermal activity mainly coincided with and closely followed major magmatic pulses during the development of the field and together spanned more than 4.5 m.y. Rocks of the SWNVF consist largely of rhyolitic ash-flow sheets and intercalated silicic lava domes, flows and near-vent pyroclastic deposits erupted between 15.2 and 10 Ma from vent areas in the vicinity of the Timber Mountain calderas, and between about 9.5 and 7 Ma from the outlying Black Mountain and Stonewall Mountain centers. Three magmatic stages can be recognized: the main magmatic stage, Mountain magmatic stage (11.7 to 10.0 Ma), and the late magmatic stage (9.4 to 7.5 Ma).

  10. Quaternary migration of active extension revealed by a syn-tectonic alluvial fan shift. A case study in the Northern Apennines of Italy

    NASA Astrophysics Data System (ADS)

    Mirabella, Francesco; Bucci, Francesco; Cardinali, Mauro; Santangelo, Michele; Guzzetti, Fausto

    2016-04-01

    In areas characterized by the progressive migration of active extension through time, shifts in the position of the active depocenter occur. Such shifts through time produces peculiar geomorphological settings that are often characterized by wind gaps, abandoned valleys, streams captures and drainage inversions. These features provide the opportunity to investigate active areas by studying the recent-most geological history of the related nearby basins. We investigate this topic in a tectonically active area in the Northern Apennines of Italy, as indicated by both instrumental and historical seismicity (maximum epicentral intensity I0=VIII) and extension rates in the order of 2.5-2.7 mm/yr. In particular, we study the Montefalco ridge drainage inversion. Here, fluvial sands and imbricated conglomerates deposited in a lower Pleistocene depocenter constituted by an extensional subsiding basin, are presently uplifted more than 200 m above the present day alluvial plain. The Montefalco ridge drainage inversion, at about 400 m a.s.l., separates two valleys, the Gualdo Cattaneo - Bastardo valley to the West (300 m a.s.l.) and the Foligno present-day alluvial plain to the East (200 m a.s.l.). Seismic reflection data show that the maximum thickness of the continental sequence in the Foligno valley is in the order of 500 m. This valley is presently occupied by a 37 km2 alluvial fan produced by the Topino river flowing from NE to SW. To unravel the Quaternary tectonic evolution of the area, we integrate different data sets collected by field mapping, detailed photo-geological data, sediments provenance information, and subsurface data. We interpret the Montefalco ridge as a paleo-Foligno-like alluvial fan representing the evidence of the recent migration of the active extension to the East of around 7 km. Considering an age of deformation of 2.5 My, an extension rate of about 2.8 mm/yr is derived, which corresponds to the present-day geodetic rates. We stress the importance

  11. A study of tectonic activity in the Basin-Range Province and on the San Andreas Fault. No. 1: Kinematics of Basin-Range intraplate extension

    NASA Technical Reports Server (NTRS)

    Eddington, P. K.; Smith, R. B.; Renggli, C.

    1986-01-01

    Strain rates assessed from brittle fracture and total brittle-ductile deformation measured from geodetic data were compared to estimates of paleo-strain from Quaternary geology for the intraplate Great Basin part of the Basin-Range, western United States. These data provide an assessment of the kinematics and mode of lithospheric extension that the western U.S. Cordillera has experienced from the past few million years to the present. Strain and deformation rates were determined by the seismic moment tensor method using historic seismicity and fault plane solutions for sub-regions of homogeneous strain. Contemporary deformation in the Great Basin occurs principally along the active seismic zones. The integrated opening rate across the entire Great Basin is accommodated by E-E extension at 8 to 10 mm/a in the north that diminishes to NW-SE extension of 3.5 mm/a in the south. Zones of maximum lithospheric extension correspond to belts of thin crust, high heat flow, and Quaternary basaltic volcanism, suggesting that these parameters are related through mechanism of extension such as a stress relaxation, allowing bouyant uplift and ascension of magmas.

  12. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

    PubMed Central

    2012-01-01

    Background This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer’s disease (AD). Methods In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus. Results Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%). In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets), with gene responses primarily restricted to the SFG and HC. Second, relatively few significant changes in immune/inflammation genes were detected in the EC either in aging or AD, although many genes in the EC showed similar trends in responses as in the other brain regions. Third, immune/inflammation genes undergo gender-specific patterns of response in aging and AD, with the most pronounced differences emerging in aging. Finally, there was widespread upregulation of genes reflecting activation of microglia and perivascular macrophages in the aging brain, coupled with a downregulation of select factors (TOLLIP, fractalkine) that when present curtail microglial/macrophage activation. Notably, essentially all pathways of the innate immune system were upregulated in aging, including numerous complement components, genes involved in toll-like receptor signaling and inflammasome signaling, as well as genes coding for immunoglobulin (Fc) receptors and human leukocyte antigens I

  13. 75 FR 28052 - MMS Information Collection Activity: 1010-0051, Oil and Gas Production Measurement, Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... (74 FR 56858) announcing that we would submit this ICR to OMB for approval. The notice provided the... Measurement, Extension of a Collection; Submitted for Office of Management and Budget (OMB) Review; Comment... Measurement,'' and related documents. This notice also provides the public a second opportunity to comment...

  14. Sugar beet activities of the USDA-ARS East Lansing conducted in cooperation with Saginaw Research & Extension Center during 2014

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evaluation and rating plots were planted at the Saginaw Valley Research & Extension Center (SVREC) in Frankenmuth, MI in 2014 that focused on Cercospora leaf spot (CLS) and Rhizoctonia crown and root rot (CRR) disease performance of a wide range of Beta vulgaris materials. CLS and CRR trials were co...

  15. 76 FR 23833 - Agency Information Collection Activities: Supplement A to Form I-539: Extension of an Existing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... Notice of Information Collection Under Review: Supplement A to Form I-539 (Filing Instructions for V... comments concerning the extension of Supplement A to Form I- 539 (Filing Instructions for V Nonimmigrant... V Nonimmigrant Status Applicants). (3) Agency form number, if any, and the applicable component...

  16. Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway.

    PubMed

    Formstone, Caroline J; Mason, Ivor

    2005-06-15

    The seven-transmembrane protocadherin, Flamingo, functions in a number of processes during Drosophila development, including planar cell polarity (PCP). To assess the role(s) of Flamingo1/Celsr1 (Fmi1) during vertebrate embryogenesis we have exploited the zebrafish system, identifying two Fmi1 orthologues (zFmi1a and zFmi1b) and employing morpholinos to induce mis-splicing of zebrafish fmi1 mRNAs, to both imitate mutations identified in Drosophila flamingo and generate novel aberrant Flamingo proteins. We demonstrate that in the zebrafish gastrula, Fmi1 proteins function in concert with each other and with the vertebrate PCP proteins, Wnt11 and Strabismus, to mediate convergence and extension during gastrulation, without altering early dorso-ventral patterning. We show that zebrafish Fmi1a promotes extension of the entire antero-posterior axis of the zebrafish gastrula including prechordal plate and ventral diencephalic precursors. However, while we show that control over axial extension is autonomous, we find that Fmi1a is not required within lateral cells undergoing dorsal convergence. PMID:15882862

  17. Investigation of hydrothermal activity at Campi Flegrei caldera using 3D simulations: extension to high temperature processes

    NASA Astrophysics Data System (ADS)

    Afanasyev, Andrey; Costa, Antonio; Chiodini, Giovanni

    2015-04-01

    Hydrothermal activity at Campi Flegrei caldera is simulated by using the multiphase code MUFITS (www.mufits.imec.msu.ru). We provide a brief description of the simulator covering the mathematical formulation and its applicability at elevated supercritical temperatures. Then we apply, for the first time, the code to hydrothermal systems investigating the Campi Flegrei caldera case. We consider both shallow subcritical regions and deep supercritical regions of the hydrothermal system. We impose sophisticated boundary conditions at the surface to provide a better description of the reservoir interactions with the atmosphere and the sea. Finally we carry out a parametric study and compare the simulation results with gas temperature and composition, gas and heat fluxes, and temperature measurements in the wells of that area. Results of the parametric study show that flow rate, composition, and temperature of the hot gas mixture injected at depth, and the initial geothermal gradient strongly control parameters monitored at Solfatara. Comparisons with observations show a very good match and suggest that the best guesses for the injected hot (~700 C) fluid mass flow rate is about 50-100 kg/s and the initial geothermal gradient is 120 C/km. Of particular interest resulted the comparison between the simulated thermal profiles and those measured in geothermal wells. Keeping in mind the uncertainties due to the heterogeneities of the system, the good match obtained for the wells in the eastern and north sectors of the caldera (located some km far from Solfatara) suggest that the model can reproduce the gross features of the Campi Flegrei hydrothermal system and implicitly support the hypothesis of a single (or major) deep source of magmatic fluid located close to the centre of the caldera. Surprising results were also obtained by comparing simulated and observed (Agnano well) temperature profiles in a zone close to the gas plume: in this case the simulations clearly suggested

  18. Phenotypic debrisoquine 4-hydroxylase activity among extensive metabolizers is unrelated to genotype as determined by the Xba-I restriction fragment length polymorphism.

    PubMed Central

    Turgeon, J; Evans, W E; Relling, M V; Wilkinson, G R; Roden, D M

    1991-01-01

    1. The major pathway for 4-hydroxylation of debrisoquine in man is polymorphic and under genetic control. More than 90% of subjects (extensive metabolizers, EMs) have active debrisoquine 4-hydroxylase (cytochrome P450IID6) while in the remainder (poor metabolizers, PMs), cytochrome P450IID6 activity is greatly impaired. 2. Within the EM group, cytochrome P450IID6-mediated metabolism of a range of substrates varies widely. Some of this intra-phenotype non-uniformity may be explained by the presence of two subsets of subjects with different genotypes (heterozygotes and homozygotes). 3. Cytochrome P450IID6 substrates have not differentiated between these two genotypes. However, a restriction fragment length polymorphism (RFLP) which identifies mutant alleles of cytochrome P450IID6 locus has been described and can definitively assign genotype in some heterozygous EM subjects. 4. In this study, we used RFLP analysis and encainide as a model substrate to determine if non-uniformity in cytochrome P450IID6 activity among EMs is related to genotype. We tested the hypothesis that heterozygotes exhibit intermediate metabolic activity and that homozygous dominants exhibit the highest activity. We proposed encainide as a useful substrate for this purpose since cytochrome P450IID6 catalyzes not only its biotransformation to O-desmethyl encainide (ODE) but also the subsequent metabolism of ODE to 3-methoxy-O-desmethyl encainide (MODE). 5. A single 50 mg oral dose of encainide was administered to 139 normal volunteers and 14 PMs were identified. Urinary ratios among encainide, ODE and MODE in the remaining 125 EM subjects revealed a wide range of cytochrome P450IID6 activity. However, Southern blotting of genomic DNA digested with XbaI identified obligate heterozygotes in both extremes of all ratio distributions.(ABSTRACT TRUNCATED AT 250 WORDS) Images Figure 2 PMID:1685663

  19. Physical activity

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/001941.htm Physical activity To use the sharing features on this page, please enable JavaScript. Physical activity -- which includes an active lifestyle and routine exercise -- ...

  20. Activation detector

    DOEpatents

    Bell, Zane William [Oak Ridge, TN; Boatner, Lynn Allen [Oak Ridge, TN

    2009-12-08

    A method of detecting an activator, the method including impinging with an activator a receptor material lacking a photoluminescent material and generating a by-product of a radioactive decay due to the activator impinging the reeptor material. The method further including, generating light from the by-product via the Cherenkov effect and identifying a characteristic of the activator based on the light.

  1. Extension of excitation functions up to 50 MeV for activation products in deuteron irradiations of Pr and Tm targets

    NASA Astrophysics Data System (ADS)

    Hermanne, A.; Tárkányi, F.; Takács, S.; Ditrói, F.

    2016-09-01

    Extension up to 50 MeV incident deuteron energy is presented for excitation functions of activation products formed in monoisotopic Tm (169Tm) and Pr (141Pr). By stacked foil irradiations direct and/or cumulative production of 140,139m,138Nd, 138mPr, 141,139,137m,135Ce on Pr and 166,169Yb, 166,167,168Tm on Tm targets were measured. Confirmation of earlier experimental results for all investigated radionuclides is found and the influence of the higher energy on thick target yields and batch production of medically relevant radionuclides (140Nd, 139Pr (as decay product of 139mNd), 166,169Yb, 167Tm) is discussed. A comparison of experimental values with TALYS1.6 code results (predicted values from TENDL-2015 on-line library) shows a better description of the (d,pxn) reactions than older ones.

  2. Growth maintenance of the maize primary root at low water potentials involves increases in cell-wall extension properties, expansin activity, and wall susceptibility to expansins.

    PubMed Central

    Wu, Y; Sharp, R E; Durachko, D M; Cosgrove, D J

    1996-01-01

    Previous work on the growth biophysics of maize (Zea mays L.) primary roots suggested that cell walls in the apical 5 mm of the elongation zone increased their yielding ability as an adaptive response to low turgor and water potential (psi w). To test this hypothesis more directly, we measured the acid-induced extension of isolated walls from roots grown at high (-0.03 MPa) or low (-1.6 MPa) psi w using an extensometer. Acid-induced extension was greatly increased in the apical 5 mm and was largely eliminated in the 5- to 10-mm region of roots grown at low psi w. This pattern is consistent with the maintenance of elongation toward the apex and the shortening of the elongation zone in these roots. Wall proteins extracted from the elongation zone possessed expansin activity, which increased substantially in roots grown at low psi w. Western blots likewise indicated higher expansin abundance in the roots at low psi w. Additionally, the susceptibility of walls to expansin action was higher in the apical 5 mm of roots at low psi w than in roots at high psi w. The basal region of the elongation zone (5-10 mm) did not extend in response to expansins, indicating that loss of susceptibility to expansins was associated with growth cessation in this region. Our results indicate that both the increase in expansin activity and the increase in cell-wall susceptibility to expansins play a role in enhancing cell-wall yielding and, therefore, in maintaining elongation in the apical region of maize primary roots at low psi w. PMID:11536740

  3. Active turbulence in active nematics

    NASA Astrophysics Data System (ADS)

    Thampi, S. P.; Yeomans, J. M.

    2016-07-01

    Dense, active systems show active turbulence, a state characterised by flow fields that are chaotic, with continually changing velocity jets and swirls. Here we review our current understanding of active turbulence. The development is primarily based on the theory and simulations of active liquid crystals, but with accompanying summaries of related literature.

  4. Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals

    PubMed Central

    Pickering, Suzanne; Hué, Stephane; Kim, Eun-Young; Reddy, Susheel; Wolinsky, Steven M.; Neil, Stuart J. D.

    2014-01-01

    The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires throughout infection in 14 individuals infected with HIV-1 clade B revealed extensive amino acid diversity of the Vpu protein. For the most part, this variation in Vpu increases over the course of infection and is associated with predicted epitopes of the individual's MHC class I haplotype, suggesting CD8+ T cell pressure is the major driver of Vpu sequence diversity within the host. Despite this variability, the Vpu functions of targeting CD4 and counteracting both physical virus restriction and NF-κB activation by tetherin are rigorously maintained throughout HIV-1 infection. Only a minority of circulating alleles bear lesions in either of these activities at any given time, suggesting functional Vpu mutants are heavily selected against even at later stages of infection. Comparison of Vpu proteins defective for one or several functions reveals novel determinants of CD4 downregulation, counteraction of tetherin restriction, and inhibition of NF-κB signalling. These data affirm the importance of Vpu functions for in vivo persistence of HIV-1 within infected individuals, not simply for transmission, and highlight its potential as a target for antiviral therapy. PMID:24465210

  5. Activity of Colistin in Combination with Meropenem, Tigecycline, Fosfomycin, Fusidic Acid, Rifampin or Sulbactam against Extensively Drug-Resistant Acinetobacter baumannii in a Murine Thigh-Infection Model

    PubMed Central

    Wang, Xiumei; Cong, Yulong

    2016-01-01

    Few effective therapeutic options are available for treating severe infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). Using a murine thigh-infection model, we examined the in vivo efficacy of colistin in combination with meropenem, tigecycline, fosfomycin, fusidic acid, rifampin, or sulbactam against 12 XDR-AB strains. Colistin, tigecycline, rifampin, and sulbactam monotherapy significantly decreased bacterial counts in murine thigh infections compared with those observed in control mice receiving no treatment. Colistin was the most effective agent tested, displaying bactericidal activity against 91.7% of strains at 48 h post-treatment. With strains showing a relatively low minimum inhibitory concentration (MIC) for meropenem (MIC ≤ 32 mg/L), combination therapy with colistin plus meropenem caused synergistic inhibition at both 24 h and 48 h post-treatment. However, when the meropenem MIC was ≥64 mg/L, meropenem did not significantly alter the efficacy of colistin. The addition of rifampin and fusidic acid significantly improved the efficacy of colistin, showing a synergistic effect in 100% and 58.3% of strains after 24 h of treatment, respectively, while the addition of tigecycline, fosfomycin, or sulbactam did not show obvious synergistic activity. No clear differences in activities were observed between colistin-rifampin and colistin-fusidic acid combination therapy with most strains. Overall, our in vivo study showed that administering colistin in combination with rifampin or fusidic acid is more efficacious in treating XDR-AB infections than other combinations. The colistin-meropenem combination may be another appropriate option if the MIC is ≤32 mg/L. Further clinical studies are urgently needed to confirm the relevance of these findings. PMID:27315107

  6. In vitro activities of sitafloxacin tested alone and in combination with rifampin, colistin, sulbactam, and tigecycline against extensively drug-resistant Acinetobacter baumannii

    PubMed Central

    Dong, Xiaomeng; Chen, Fengzhe; Zhang, Yajun; Liu, Haihong; Liu, Yongjuan; Ma, Lixian

    2015-01-01

    Objectives: To detect the in vitro activities of sitafloxacin alone and in combination with rifampin, colistin, sulbactam, and tigecycline against extensively drug-resistant Acinetobacter baumannii (XDR-A. baumannii). Materials and methods: 24 XDR-A. baumannii strains were isolated from patients’ specimens. Broth microdilution assay was used to determine the minimum inhibitory concentration (MIC) for sitafloxacin, rifampin, colistin, sulbactam, and tigecycline against XDR-A. baumannii strains. The checkerboard microdilution method was used to determine the in vitro activities of sitafloxacin combined with the other four antimicrobial agents. Accordingly, the fractional inhibitory concentration (FIC) and FIC index (FICI) were calculated for each of the combinations. Results: According to our results, when tested alone, the rate of susceptibility for sitafloxacin was 91.67% against XDR-A. baumannii, followed by colistin 62.5%, and then tigecycline 54.17%, rifampin 41.67%. Sulbactam, with a 16.67% rate of susceptibility was the least effective one. On the other hand, when tested in combination, all those three combinations except tigecycline/sitafloxacin revealed remarkable synergistic effects. Colistin/sitafloxacin showed the highest indifference rate. These combination regimens could exert addictive or partially-synergistic effects at the sub-MIC levels against XDR-A. baumannii strains. Conclusion: Sitafloxacin has acceptable in vitro activity against XDR-A. baumannii strains as well as tigecycline, rifampin and colistin. Compared with single drugs, most of the combinations of these antimicrobial agents could exert synergistic and/or partially synergistic and/or addictive effects, which might provide a better alternative when treating XDR-A. baumannii infections. PMID:26221381

  7. Physical activity

    MedlinePlus

    ... time they spend watching TV and using a computer and other electronic devices. All of these activities ... U.S. Department of Health and Human Services. Physical Activity Guidelines for Americans: Recommendation ... Page last updated: ...

  8. Activity Scale.

    ERIC Educational Resources Information Center

    Kerpelman, Larry C.; Weiner, Michael J.

    This twenty-four item scale assesses students' actual and desired political-social activism in terms of physical participation, communication activities, and information-gathering activities. About ten minutes are required to complete the instrument. The scale is divided into two subscales. The first twelve items (ACT-A) question respondents on…

  9. Genome differentiation in a species pair of coregonine fishes: an extremely rapid speciation driven by stress-activated retrotransposons mediating extensive ribosomal DNA multiplications

    PubMed Central

    2013-01-01

    in both genomes, thus, leading to a rapid genome divergence. We attribute these extensive genome re-arrangements associated with speciation event to stress-induced retrotransposons (re)activation. Such causal interplay between genome differentiation, retrotransposons (re)activation and environmental conditions may become a topic to be explored in a broader genomic context in future evolutionary studies. PMID:23410024

  10. In Vitro Activity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B.

    PubMed

    Cai, Yiying; Lim, Tze-Peng; Teo, Jocelyn; Sasikala, Suranthran; Lee, Winnie; Hong, Yanjun; Chan, Eric Chun Yong; Tan, Thean Yen; Tan, Thuan-Tong; Koh, Tse Hsien; Hsu, Li Yang; Kwa, Andrea L

    2016-09-01

    Against extensively drug-resistant (XDR) Enterobacter cloacae, combination antibiotic therapy may be the only option. We investigated the activity of various antibiotics in combination with polymyxin B using time-kill studies (TKS). TKS were conducted with four nonclonal XDR E. cloacae isolates with 5 log10 CFU/ml bacteria against maximum, clinically achievable concentrations of polymyxin B alone and in two-drug combinations with 10 different antibiotics. A hollow-fiber infection model (HFIM) simulating clinically relevant polymyxin B and tigecycline dosing regimens was conducted for two isolates over 240 h. Emergence of resistance was quantified using antibiotic-containing (3× MIC) media. Biofitness and stability of resistant phenotypes were determined. All XDR E. cloacae isolates were resistant to all antibiotics except for polymyxin B (polymyxin B MIC, 1 to 4 mg/liter). All isolates harbored metallo-β-lactamases (two with NDM-1, two with IMP-1). In single TKS, all antibiotics alone demonstrated regrowth at 24 h, except amikacin against two strains and polymyxin B and meropenem against one strain each. In combination TKS, only polymyxin B plus tigecycline was bactericidal against all four XDR E. cloacae isolates at 24 h. In HFIM, tigecycline and polymyxin B alone did not exhibit any killing activity. Bactericidal kill was observed at 24 h for both isolates for polymyxin B plus tigecycline; killing was sustained for one isolate but regrowth was observed for the second. Phenotypically stable resistant mutants with reduced in vitro growth rates were observed. Polymyxin B plus tigecycline is a promising combination against XDR E. cloacae However, prolonged and indiscriminate use can result in resistance emergence. PMID:27324776

  11. Role of the C-terminal Extension of Formin 2 in Its Activation by Spire Protein and Processive Assembly of Actin Filaments.

    PubMed

    Montaville, Pierre; Kühn, Sonja; Compper, Christel; Carlier, Marie-France

    2016-02-12

    Formin 2 (Fmn2), a member of the FMN family of formins, plays an important role in early development. This formin cooperates with profilin and Spire, a WASP homology domain 2 (WH2) repeat protein, to stimulate assembly of a dynamic cytoplasmic actin meshwork that facilitates translocation of the meiotic spindle in asymmetric division of mouse oocytes. The kinase-like non-catalytic domain (KIND) of Spire directly interacts with the C-terminal extension of the formin homology domain 2 (FH2) domain of Fmn2, called FSI. This direct interaction is required for the synergy between the two proteins in actin assembly. We have recently demonstrated how Spire, which caps barbed ends via its WH2 domains, activates Fmn2. Fmn2 by itself associates very poorly to filament barbed ends but is rapidly recruited to Spire-capped barbed ends via the KIND domain, and it subsequently displaces Spire from the barbed end to elicit rapid processive assembly from profilin·actin. Here, we address the mechanism by which Spire and Fmn2 compete at barbed ends and the role of FSI in orchestrating this competition as well as in the processivity of Fmn2. We have combined microcalorimetric, fluorescence, and hydrodynamic binding assays, as well as bulk solution and single filament measurements of actin assembly, to show that removal of FSI converts Fmn2 into a Capping Protein. This activity is mimicked by association of KIND to Fmn2. In addition, FSI binds actin at filament barbed ends as a weak capper and plays a role in displacing the WH2 domains of Spire from actin, thus allowing the association of actin-binding regions of FH2 to the barbed end. PMID:26668326

  12. Active ratchets

    NASA Astrophysics Data System (ADS)

    Angelani, L.; Costanzo, A.; Di Leonardo, R.

    2011-12-01

    We analyze self-propelling organisms, or active particles, in a periodic asymmetric potential. Unlike standard ratchet effect for Brownian particles requiring external forcing, in the case of active particles asymmetric potential alone produces a net drift speed (active ratchet effect). By using theoretical models and numerical simulations we demonstrate the emergence of the rectification process in the presence of an asymmetric piecewise periodic potential. The broken spatial symmetry (external potential) and time symmetry (active particles) are sufficient ingredients to sustain unidirectional transport. Our findings open the way to new mechanisms to move in directional manner motile organisms by using external periodic static fields.

  13. Faculty Activism

    ERIC Educational Resources Information Center

    Academe, 2005

    2005-01-01

    Blending scholarship and activism, whether domestic or international, takes some real work. Two scholar-activists reflect on why and how activism can be more than academic labor in this feature of the "Academe" journal. This feature includes the following brief reflections on political work, both local and global that demonstrates how on campus…

  14. Indoor Activities

    MedlinePlus

    ... so you can do some lifting while you watch TV. Walk around the house when you talk on the phone. Make an extra trip up and down the stairs when you do the laundry. Download the Tip Sheet Indoor Activities (PDF, 739.53 KB) You Might Also Like Sun Safety Have Fun. Be Active with Your Dog! ...

  15. Catalyst activator

    DOEpatents

    McAdon, Mark H.; Nickias, Peter N.; Marks, Tobin J.; Schwartz, David J.

    2001-01-01

    A catalyst activator particularly adapted for use in the activation of metal complexes of metals of Group 3-10 for polymerization of ethylenically unsaturated polymerizable monomers, especially olefins, comprising two Group 13 metal or metalloid atoms and a ligand structure including at least one bridging group connecting ligands on the two Group 13 metal or metalloid atoms.

  16. Outdoor Activities.

    ERIC Educational Resources Information Center

    Minneapolis Independent School District 275, Minn.

    Twenty-four activities suitable for outdoor use by elementary school children are outlined. Activities designed to make children aware of their environment include soil painting, burr collecting, insect and pond water collecting, studies of insect galls and field mice, succession studies, and a model of natural selection using dyed toothpicks. A…

  17. Astronomy Activities.

    ERIC Educational Resources Information Center

    Greenstone, Sid

    This document consists of activities and references for teaching astronomy. The activities (which include objectives, list of materials needed, and procedures) focus on: observing the Big Dipper and locating the North Star; examining the Big Dipper's stars; making and using an astrolabe; examining retograde motion of Mars; measuring the Sun's…

  18. Activated Charcoal

    MedlinePlus

    ... ACTIVATED CHARCOAL are as follows:Trapping chemicals to stop some types of poisoning when used as a ... Charbon Végétal, Charbon Végétal Activé, Charcoal, Gas Black, Lamp Black, Medicinal Charcoal, Noir de Gaz, Noir de ...

  19. On the Use of the Passive and Active Voice in Astrophysics Journal Papers: With Extensions to Other Languages and Other Fields.

    ERIC Educational Resources Information Center

    Tarone, Elaine; Dwyer, Sharon; Gillette, Susan; Icke, Vincent.

    1998-01-01

    A study examined frequency of active, passive verb forms in two astrophysics journal articles, finding "we" plus an active voice occurs at least as frequently as the passive. This pattern typifies a previously unidentified type of research article, the logical argument scientific paper, whose characteristics are detailed. Similar pattern is seen…

  20. Early Jurassic Volcanism in the South Lhasa Terrane, Southern Tibet: Record of Back-arc Extension in the Active Continental Margin

    NASA Astrophysics Data System (ADS)

    Wei, Y.; Zhao, Z.; Zhu, D. C.; Wang, Z.; Liu, D.; Mo, X.

    2015-12-01

    Indus-Yarlung Zangbo Suture Zone (IYZSZ) represents the Mesozoic remnants of the Neo-Tethyan Ocean lithosphere after its northward subduction beneath the Lhasa Terrane. The evolution of the Neo-Tethyan Ocean prior to India-Asia collision remains unclear. To explore this period of history, we investigate zircon U-Pb geochronology, geochemistry and Nd-Hf isotopes of the Early Jurassic bimodal-like volcanic sequence around Dagze area, south Tibet. The volcanic sequence comprises calc-alkaline basalts to rhyolites whereas intermediate components are volumetrically restricted. Zircons from a basaltic andesite yielded crystallization age of 178Ma whereas those from 5 silicic rocks were dated at 183-174Ma, which suggest that both the basaltic and the silicic rocks are coeval. The basaltic rocks are enriched in LREE and LILE, and depleted in HFSE, with Epsilon Nd(t) of 1.6-4.0 and zircon Epsilon Hf(t) of 0.7-11.8, which implies that they were derived from a heterogenetic mantle source metasomatized by subduction components. Trace element geochemistry shows that the basaltic rocks are compositionally transitional from normal mid-ocean ridge basalts (N-MORB) to island arc basalts (IAB, e.g. Zedong arc basalts of ~160-155Ma in the south margin of Lhasa Terrane), with the signature of immature back-arc basin basalts. The silicic rocks display similar Nd-Hf isotopic features of the Gangdese batholith with Epsilon Nd(t) of 0.9-3.4 and zircon Epsilon Hf(t) of 2.4-17.7, indicating that they were possibly generated by anatexis of basaltic juvenile lower crust, instead of derived from the basaltic magma. These results support an Early to Middle Jurassic (183-155Ma) model that the back-arc extension tectonic setting were existing in the active continental margin in the south Lhasa Terrane.

  1. Activated Charcoal

    MedlinePlus

    ... is used to treat poisonings, reduce intestinal gas (flatulence), lower cholesterol levels, prevent hangover, and treat bile ... lower cholesterol levels in the blood. Decreasing gas (flatulence). Some studies show that activated charcoal is effective ...

  2. Activation analysis

    SciTech Connect

    Alfassi, Z.B. . Dept. of Nuclear Engineering)

    1990-01-01

    This volume contains 16 chapters on the application of activation analysis in the fields of life sciences, biological materials, coal and its effluents, environmental samples, archaeology, material science, and forensics. Each chapter is processed separately for the data base.

  3. Get Active

    MedlinePlus

    ... section Health Conditions 4 of 10 sections Take Action! Take Action: How Active Are You? First, think about your ... section Learn More 5 of 10 sections Take Action: Get Started I’m just getting started. Start ...

  4. Maintenance of Efficacy and Continuing Safety of Golimumab for Active Ulcerative Colitis: PURSUIT-SC Maintenance Study Extension Through 1 Year

    PubMed Central

    Gibson, Peter R; Feagan, Brian G; Sandborn, William J; Marano, Colleen; Strauss, Richard; Johanns, Jewel; Padgett, Lakshmi; Collins, Judith; Tarabar, Dino; Hebzda, Zbigniew; Rutgeerts, Paul; Reinisch, Walter

    2016-01-01

    Objectives: The safety and efficacy of subcutaneous golimumab through 2 years of maintenance therapy was evaluated in patients with moderate-to-severe ulcerative colitis (UC). Methods: Patients completing treatment through week 52 (placebo, golimumab 50, 100, every-4-weeks (q4w)) and evaluations at week 54 were eligible for this long-term extension (LTE) trial. Patients receiving placebo or golimumab 50 mg with worsening disease during the LTE could receive golimumab 100 mg. Efficacy assessments included the Mayo physician's global assessment (PGA) subscore, inflammatory bowel disease questionnaire (IBDQ), and corticosteroid use. Patients who were randomized to golimumab at PURSUIT-Maintenance baseline and continued receiving golimumab during the LTE were analyzed for efficacy (using intention-to-treat and “as observed” analyses; N=195) and safety (N=200). Patients treated with golimumab at any time from induction baseline through week 104 (N=1240) constituted the overall safety population. Results: Baseline demographics and disease characteristics of patients entering the LTE receiving golimumab were similar to those of all patients randomized to golimumab maintenance at baseline. At week 104, 80.5% (157/195) of patients had a PGA=0/1 (range weeks 56–104: 80.5–91.8%) and 56.4% (110/195) had a PGA=0 (weeks 56–104: range: 53.8–58.5%). Through week 104, 86% of patients maintained inactive or mild disease activity. Among 174 corticosteroid-free patients at week 54, 88.5% remained corticosteroid-free at week 104. At week 104, 62.2% (120/193) had an IBDQ score ≥170. Tuberculosis, opportunistic infection, and malignancy rates were low, and the overall safety profile was similar to that reported through week 54. Two non-melanoma skin cancers, one metastatic colon cancer, and two deaths (biventricular heart dysfunction, sepsis) occurred between weeks 54 and 104. Conclusion: Subcutaneous golimumab q4w through 2 years maintained clinical benefit and reduced

  5. Integrin activation

    PubMed Central

    Ginsberg, Mark H.

    2014-01-01

    Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate. Conversely, cells can modulate the affinity of integrins for their ligands a process operationally defined as integrin activation. Analysis of activation of integrins has now provided a detailed molecular understanding of this unique form of “inside-out” signal transduction and revealed new paradigms of how transmembrane domains (TMD) can transmit long range allosteric changes in transmembrane proteins. Here, we will review how talin and mediates integrin activation and how the integrin TMD can transmit these inside out signals. [BMB Reports 2014; 47(12): 655-659] PMID:25388208

  6. Active Cytokinins

    PubMed Central

    Mornet, René; Theiler, Jane B.; Leonard, Nelson J.; Schmitz, Ruth Y.; Moore, F. Hardy; Skoog, Folke

    1979-01-01

    Four series of azidopurines have been synthesized and tested for cytokinin activity in the tobacco callus bioassay: 2- and 8-azido-N6-benzyladenines, -N6-(Δ2-isopentenyl)adenines, and -zeatins, and N6-(2- and 4-azidobenzyl)adenines. The compounds having 2-azido substitution on the adenine ring are as active as the corresponding parent compounds, while those with 8-azido substitution are about 10 or more times as active. The 8-azidozeatin, which is the most active cytokinin observed, exhibited higher than minimal detectable activity at 1.2 × 10−5 micromolar, the lowest concentration tested. The shape of the growth curve indicates that even a concentration as low as 5 × 10−6 micromolar would probably be effective. By comparison, the lowest active concentration ever reported for zeatin has been 5 × 10−5 micromolar, representing a sensitivity rarely attained. All of the azido compounds have been submitted to photolysis in aqueous ethanol, and the photoproducts have been detected and identified by low and high resolution mass spectrometry. They are rationalized as products of abstraction and insertion reactions of the intermediate nitrenes. The potential of the major released products as cytokinins was also assessed by bioassay. 2-Azido-N6-(Δ2-isopentenyl)adenine competed with [14C]kinetin for the cytokinin-binding protein isolated from wheat germ. When the azido compound was photolysed in the presence of this protein, its attachment effectively blocked the binding of [14C]kinetin. PMID:16661017

  7. Photocatalytic activity of PANI loaded coordination polymer composite materials: Photoresponse region extension and quantum yields enhancement via the loading of PANI nanofibers on surface of coordination polymer

    SciTech Connect

    Cui, Zhongping; Qi, Ji; Xu, Xinxin Liu, Lu; Wang, Yi

    2013-09-15

    To enhance photocatalytic property of coordination polymer in visible light region, polyaniline (PANI) loaded coordination polymer photocatalyst was synthesized through in-situ chemical oxidation of aniline on the surface of coordination polymer. The photocatalytic activity of PANI loaded coordination polymer composite material for degradation of Rhodamine B (RhB) was investigated. Compared with pure coordination polymer photocatalyst, which can decompose RhB merely under UV light irradiation, PANI loaded coordination polymer photocatalyst displays more excellent photocatalytic activity in visible light region. Furthermore, PANI loaded coordination polymer photocatalyst exhibits outstanding stability during the degradation of RhB. - Graphical abstract: PANI loaded coordination polymer composite material, which displays excellent photocatalytic activity under visible light was firstly synthesized through in-situ chemical oxidation of aniline on surface of coordination polymer. Display Omitted - Highlights: • This PANI loaded coordination polymer composite material represents the first conductive polymer loaded coordination polymer composite material. • PANI/coordination polymer composite material displays more excellent photocatalytic activity for the degradation of MO in visible light region. • The “combination” of coordination polymer and PANI will enable us to design high-activity, high-stability and visible light driven photocatalyst in the future.

  8. Get Active

    MedlinePlus

    ... Lifting small weights – you can even use bottled water or cans of food as weights Watch these videos for muscle strengthening exercises to do at home or at the gym. If you do muscle-strengthening activities with weights, check out the do’s and don’ ...

  9. Learning Activities.

    ERIC Educational Resources Information Center

    Tipton, Tom, Ed.

    1983-01-01

    Presents a flow chart for naming inorganic compounds. Although it is not necessary for students to memorize rules, preliminary skills needed before using the chart are outlined. Also presents an activity in which the mass of an imaginary atom is determined using lead shot, Petri dishes, and a platform balance. (JN)

  10. Activated Sludge.

    ERIC Educational Resources Information Center

    Saunders, F. Michael

    1978-01-01

    Presents the 1978 literature review of wastewater treatment. This review covers: (1) activated sludge process; (2) process control; (3) oxygen uptake and transfer; (4) phosphorus removal; (5) nitrification; (6) industrial wastewater; and (7) aerobic digestion. A list of 136 references is also presented. (HM)

  11. Activity report

    SciTech Connect

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  12. NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx.

    PubMed

    Katsnelson, Michael A; Lozada-Soto, Kristen M; Russo, Hana M; Miller, Barbara A; Dubyak, George R

    2016-07-01

    Nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3 (NLRP3) is a cytosolic protein that nucleates assembly of inflammasome signaling platforms, which facilitate caspase-1-mediated IL-1β release and other inflammatory responses in myeloid leukocytes. NLRP3 inflammasomes are assembled in response to multiple pathogen- or environmental stress-induced changes in basic cell physiology, including the destabilization of lysosome integrity and activation of K(+)-permeable channels/transporters in the plasma membrane (PM). However, the quantitative relationships between lysosome membrane permeabilization (LMP), induction of increased PM K(+) permeability, and activation of NLRP3 signaling are incompletely characterized. We used Leu-Leu-O-methyl ester (LLME), a soluble lysosomotropic agent, to quantitatively track the kinetics and extent of LMP in relation to NLRP3 inflammasome signaling responses (ASC oligomerization, caspase-1 activation, IL-1β release) and PM cation fluxes in murine bone marrow-derived dendritic cells (BMDCs). Treatment of BMDCs with submillimolar (≤1 mM) LLME induced slower and partial increases in LMP that correlated with robust NLRP3 inflammasome activation and K(+) efflux. In contrast, supramillimolar (≥2 mM) LLME elicited extremely rapid and complete collapse of lysosome integrity that was correlated with suppression of inflammasome signaling. Supramillimolar LLME also induced dominant negative effects on inflammasome activation by the canonical NLRP3 agonist nigericin; this inhibition correlated with an increase in NLRP3 ubiquitination. LMP elicited rapid BMDC death by both inflammasome-dependent pyroptosis and inflammasome-independent necrosis. LMP also triggered Ca(2+) influx, which attenuated LLME-stimulated NLRP3 inflammasome signaling but potentiated LLME-induced necrosis. Taken together, these studies reveal a previously unappreciated signaling network that defines the coupling between LMP, changes

  13. Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine

    PubMed Central

    Aiyelaagbe, Olapeju O.; Hamid, Amao A.; Fattorusso, Ernesto; Taglialatela-Scafati, Orazio; Schröder, Heinz C.; Müller, Werner E. G.

    2011-01-01

    Extracts from Jatropha curcas, a plant used in African traditional medicine for various diseases, were tested for cytotoxic activity. The root extracts strongly reduced cell growth of tumor cells in vitro, a result consistent with the knowledge of the application of these plant extracts in traditional medicine, especially to cure/ameliorate cancer. A selection of pure diterpenoids existing in extracts from Jatropha species and isolated from J. curcas, for example, curcusone C, curcusone D, multidione, 15-epi-4Z-jatrogrossidentadion, 4Z-jatrogrossidentadion, 4E-jatrogrossidentadion, 2-hydroxyisojatrogrossidion, and 2-epi-hydroxyisojatrogrossidion, were likewise tested, and they also showed strong cytotoxic activity. It turned out that these extracts are highly active against L5178y mouse lymphoma cells and HeLa human cervix carcinoma cells, while they cause none or only very low activity against neuronal cell, for example, PC12. These data underscore that extracts from J. curcas or pure secondary metabolites from the plant are promising candidates to be anticancer drug, combined with low neuroactive effects. PMID:21754941

  14. Laboratory Activities

    SciTech Connect

    Brown, Christopher F.; Serne, R. Jeffrey

    2008-01-17

    This chapter summarizes the laboratory activities performed by PNNL’s Vadose Zone Characterization Project in support of the Tank Farm Vadose Zone Program, led by CH2M HILL Hanford Group, Inc. The results of these studies are contained in numerous reports (Lindenmeier et al. 2002; Serne et al. 2002a, 2002b, 2002c, 2002d, 2002e; Lindenmeier et al. 2003; Serne et al. 2004a, 2004b; Brown et al. 2005, 2006a, 2007; Serne et al. 2007) and have generated much of the data reported in Chapter 22 (Geochemistry-Contaminant Movement), Appendix G (Geochemistry-Contaminant Movement), and Cantrell et al. (2007, SST WMA Geochemistry Data Package – in preparation). Sediment samples and characterization results from PNNL’s Vadose Zone Characterization Project are also shared with other science and technology (S&T) research projects, such as those summarized in Chapter 12 (Associated Science Activities).

  15. Hepatoprotective Activity.

    PubMed

    2016-01-01

    The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. In this chapter, high-dose paracetamol-induced hepatotoxicity in rat model is discussed with explanations of biochemical and histopathological studies. PMID:26939279

  16. Analgesic Activity.

    PubMed

    2016-01-01

    Analgesics are agents which selectively relieve pain by acting in the CNS and peripheral pain mediators without changing consciousness. Analgesics may be narcotic or non-narcotic. The study of pain in animals raises ethical, philosophical, and technical problems. Both peripheral and central pain models are included to make the test more evident for the analgesic property of the plant. This chapter highlights methods such as hot plate and formalin and acetic acid-induced pain models to check the analgesic activity of medicinal plants. PMID:26939272

  17. Active Sonar

    NASA Astrophysics Data System (ADS)

    Sullivan, Edmund J.

    An active sonar system is one in which pulses of acoustic energy are launched into the water for the purpose of producing echoes. By examining the echoes of transmitted pulses, it affords the capability of both detecting the presence of and estimating the range, and in certain cases, the bearing, of an underwater target. In its most common arrangement, the transmitter (or projector) and the receiver are colocated. This is known as the monostatic configuration and is depicted in Figure 1. When this is not so, it is known as a bistatic or multistatic configuration.

  18. Active packaging with antifungal activities.

    PubMed

    Nguyen Van Long, N; Joly, Catherine; Dantigny, Philippe

    2016-03-01

    There have been many reviews concerned with antimicrobial food packaging, and with the use of antifungal compounds, but none provided an exhaustive picture of the applications of active packaging to control fungal spoilage. Very recently, many studies have been done in these fields, therefore it is timely to review this topic. This article examines the effects of essential oils, preservatives, natural products, chemical fungicides, nanoparticles coated to different films, and chitosan in vitro on the growth of moulds, but also in vivo on the mould free shelf-life of bread, cheese, and fresh fruits and vegetables. A short section is also dedicated to yeasts. All the applications are described from a microbiological point of view, and these were sorted depending on the name of the species. Methods and results obtained are discussed. Essential oils and preservatives were ranked by increased efficacy on mould growth. For all the tested molecules, Penicillium species were shown more sensitive than Aspergillus species. However, comparison between the results was difficult because it appeared that the efficiency of active packaging depended greatly on the environmental factors of food such as water activity, pH, temperature, NaCl concentration, the nature, the size, and the mode of application of the films, in addition to the fact that the amount of released antifungal compounds was not constant with time. PMID:26803804

  19. Active tectonics

    SciTech Connect

    Not Available

    1986-01-01

    This study is part of a series of Studies in Geophysics that have been undertaken for the Geophysics Research Forum by the Geophysics Study Committee. One purpose of each study is to provide assessments from the scientific community to aid policymakers in decisions on societal problems that involve geophysics. An important part of such assessments is an evaluation of the adequacy of current geophysical knowledge and the appropriateness of current research programs as a source of information required for those decisions. The study addresses our current scientific understanding of active tectonics --- particularly the patterns and rates of ongoing tectonic processes. Many of these processes cannot be described reasonably using the limited instrumental or historical records; however, most can be described adequately for practical purposes using the geologic record of the past 500,000 years. A program of fundamental research focusing especially on Quaternary tectonic geology and geomorphology, paleoseismology, neotectonics, and geodesy is recommended to better understand ongoing, active tectonic processes. This volume contains 16 papers. Individual papers are indexed separately on the Energy Database.

  20. Recommendations on the Nature and Level of U.S. Participation in the International Thermonuclear Experimental Reactor Extension of the Experimental Reactor Extension of the Engineering Design Activities. Panel Report To Fusion Energy Sciences Advisory Committee (FESAC)

    SciTech Connect

    none,

    1998-01-31

    The DOE Office of Energy Research chartered through the Fusion Energy Sciences Advisory Committee (FESAC) a panel to "address the topic of U. S. participation in an ITER construction phase, assuming the ITER Parties decide to proceed with construction." (Attachment 1: DOE Charge, September 1996). Given that there is expected to be a transition period of three to five years between the conclusion of the Engineering Design Activities (EDA) and the possible construction start, the DOE Office of Energy Research expanded the charge to "include the U.S. role in an interim period between the EDA and construction." (Attachment 2: DOE Expanded Charge, May 1997). This panel has heard presentations and received input from a wide cross-section of parties with an interest in the fusion program. The panel concluded it could best fulfill its responsibility under this charge by considering the fusion energy science and technology portion of the U.S. program in its entirety. Accordingly, the panel is making some recommendations for optimum use of the transition period considering the goals of the fusion program and budget pressures.

  1. Combined DTI Tractography and Functional MRI Study of the Language Connectome in Healthy Volunteers: Extensive Mapping of White Matter Fascicles and Cortical Activations.

    PubMed

    Vassal, François; Schneider, Fabien; Boutet, Claire; Jean, Betty; Sontheimer, Anna; Lemaire, Jean-Jacques

    2016-01-01

    Despite a better understanding of brain language organization into large-scale cortical networks, the underlying white matter (WM) connectivity is still not mastered. Here we combined diffusion tensor imaging (DTI) fiber tracking (FT) and language functional magnetic resonance imaging (fMRI) in twenty healthy subjects to gain new insights into the macroscopic structural connectivity of language. Eight putative WM fascicles for language were probed using a deterministic DTI-FT technique: the arcuate fascicle (AF), superior longitudinal fascicle (SLF), uncinate fascicle (UF), temporo-occipital fascicle, inferior fronto-occipital fascicle (IFOF), middle longitudinal fascicle (MdLF), frontal aslant fascicle and operculopremotor fascicle. Specific measurements (i.e. volume, length, fractional anisotropy) and precise cortical terminations were derived for each WM fascicle within both hemispheres. Connections between these WM fascicles and fMRI activations were studied to determine which WM fascicles are related to language. WM fascicle volumes showed asymmetries: leftward for the AF, temporoparietal segment of SLF and UF, and rightward for the frontoparietal segment of the SLF. The lateralization of the AF, IFOF and MdLF extended to differences in patterns of anatomical connections, which may relate to specific hemispheric abilities. The leftward asymmetry of the AF was correlated to the leftward asymmetry of fMRI activations, suggesting that the lateralization of the AF is a structural substrate of hemispheric language dominance. We found consistent connections between fMRI activations and terminations of the eight WM fascicles, providing a detailed description of the language connectome. WM fascicle terminations were also observed beyond fMRI-confirmed language areas and reached numerous cortical areas involved in different functional brain networks. These findings suggest that the reported WM fascicles are not exclusively involved in language and might be related to

  2. Combined DTI Tractography and Functional MRI Study of the Language Connectome in Healthy Volunteers: Extensive Mapping of White Matter Fascicles and Cortical Activations

    PubMed Central

    Schneider, Fabien; Boutet, Claire; Jean, Betty

    2016-01-01

    Despite a better understanding of brain language organization into large-scale cortical networks, the underlying white matter (WM) connectivity is still not mastered. Here we combined diffusion tensor imaging (DTI) fiber tracking (FT) and language functional magnetic resonance imaging (fMRI) in twenty healthy subjects to gain new insights into the macroscopic structural connectivity of language. Eight putative WM fascicles for language were probed using a deterministic DTI-FT technique: the arcuate fascicle (AF), superior longitudinal fascicle (SLF), uncinate fascicle (UF), temporo-occipital fascicle, inferior fronto-occipital fascicle (IFOF), middle longitudinal fascicle (MdLF), frontal aslant fascicle and operculopremotor fascicle. Specific measurements (i.e. volume, length, fractional anisotropy) and precise cortical terminations were derived for each WM fascicle within both hemispheres. Connections between these WM fascicles and fMRI activations were studied to determine which WM fascicles are related to language. WM fascicle volumes showed asymmetries: leftward for the AF, temporoparietal segment of SLF and UF, and rightward for the frontoparietal segment of the SLF. The lateralization of the AF, IFOF and MdLF extended to differences in patterns of anatomical connections, which may relate to specific hemispheric abilities. The leftward asymmetry of the AF was correlated to the leftward asymmetry of fMRI activations, suggesting that the lateralization of the AF is a structural substrate of hemispheric language dominance. We found consistent connections between fMRI activations and terminations of the eight WM fascicles, providing a detailed description of the language connectome. WM fascicle terminations were also observed beyond fMRI-confirmed language areas and reached numerous cortical areas involved in different functional brain networks. These findings suggest that the reported WM fascicles are not exclusively involved in language and might be related to

  3. Contusive spinal cord injury evokes localized changes in NADPH-d activity but extensive changes in Fos-like immunoreactivity in the rat.

    PubMed

    Allbutt, Haydn N; Siddall, Phillip J; Keay, Kevin A

    2007-09-01

    The histological detection of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), a marker for nitric oxide-producing cells, was used to evaluate ongoing changes in the neural biochemistry of the rat spinal cord 1 week following contusive spinal cord injury (SCI). In addition, the immunohistochemical detection of the immediate-early gene c-fos was used to identify basal patterns of neural activity at this time. The numbers and laminar locations of NADPH-d- and c-fos-positive cells were examined in spinal segments adjacent to the site of injury (T12-S3) as well as those distant from the injury (C3-C5) in both SCI and un-injured rats. Our data show that contusive SCI results in a significant reduction in NADPH-d labelling in the superficial dorsal horn, and a significant increase in NADPH-d expression in small bipolar neurons and large motoneurons in the ventral horn at the site of the injury. In spinal segments distant to the injury site (C3-C5), NADPH-d activity did not differ from that of uninjured controls. Furthermore, significant reductions in the levels of c-fos expression were observed in SCI rats, in spinal segments both at and distant to the site of injury for all spinal laminae. The only exception was a dramatic increase observed in the sacral parasympathetic nucleus. These data suggest that increased NADPH-d expression is related to conditions specific to the site of injury, whereas the changes in c-fos expression probably indicate more global changes in neuronal activity following SCI. PMID:17584182

  4. Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity.

    PubMed

    Dreifuss, Arturo Alejandro; Bastos-Pereira, Amanda Leite; Fabossi, Isabella Aviles; Lívero, Francislaine Aparecida Dos Reis; Stolf, Aline Maria; Alves de Souza, Carlos Eduardo; Gomes, Liana de Oliveira; Constantin, Rodrigo Polimeni; Furman, Aline Emmer Ferreira; Strapasson, Regiane Lauriano Batista; Teixeira, Simone; Zampronio, Aleksander Roberto; Muscará, Marcelo Nicolás; Stefanello, Maria Elida Alves; Acco, Alexandra

    2013-01-01

    This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively. The cancer model was the subcutaneous inoculation of Walker-256 tumour cells in the pelvic limb of male Wistar rat. Subsequently to the inoculation, gavage with BHE extract (50 mg.kg(-1)) or its fractions (as per the yield of the fractioning process) or vehicle (Control) was performed during 14 days. Baseline values, corresponding to individuals without tumour or treatment with UT, were also included. After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF-α level in liver and tumour homogenates, and survival rates were analysed. Both the BHE extract and its BuOH fraction successfully reduced tumour weight and volume, and modulated anti-oxidant systems. The hepatic TNF-α level indicated a greater effect from the BHE extract as compared to its BuOH fraction. Importantly, both the BHE extract and its BuOH fraction increased the survival time of the tumour-bearing animals. Inversely, the CHCl3 fraction was ineffective. These data represent an in vivo demonstration of the importance of the modulation of oxidative stress as part of the anti-neoplastic activity of UT, as well as constitute evidence of the lack of activity of isolated POAs in the primary tumour of this tumour lineage. These effects are possibly resulting from a synergic combination of substances, most of them with antioxidant properties. PMID:23408945

  5. Uncaria tomentosa Exerts Extensive Anti-Neoplastic Effects against the Walker-256 Tumour by Modulating Oxidative Stress and Not by Alkaloid Activity

    PubMed Central

    Dreifuss, Arturo Alejandro; Bastos-Pereira, Amanda Leite; Fabossi, Isabella Aviles; Lívero, Francislaine Aparecida dos Reis; Stolf, Aline Maria; Alves de Souza, Carlos Eduardo; Gomes, Liana de Oliveira; Constantin, Rodrigo Polimeni; Furman, Aline Emmer Ferreira; Strapasson, Regiane Lauriano Batista; Teixeira, Simone; Zampronio, Aleksander Roberto; Muscará, Marcelo Nicolás; Stefanello, Maria Elida Alves; Acco, Alexandra

    2013-01-01

    This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively. The cancer model was the subcutaneous inoculation of Walker-256 tumour cells in the pelvic limb of male Wistar rat. Subsequently to the inoculation, gavage with BHE extract (50 mg.kg−1) or its fractions (as per the yield of the fractioning process) or vehicle (Control) was performed during 14 days. Baseline values, corresponding to individuals without tumour or treatment with UT, were also included. After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF-α level in liver and tumour homogenates, and survival rates were analysed. Both the BHE extract and its BuOH fraction successfully reduced tumour weight and volume, and modulated anti-oxidant systems. The hepatic TNF-α level indicated a greater effect from the BHE extract as compared to its BuOH fraction. Importantly, both the BHE extract and its BuOH fraction increased the survival time of the tumour-bearing animals. Inversely, the CHCl3 fraction was ineffective. These data represent an in vivo demonstration of the importance of the modulation of oxidative stress as part of the anti-neoplastic activity of UT, as well as constitute evidence of the lack of activity of isolated POAs in the primary tumour of this tumour lineage. These effects are possibly resulting from a synergic combination of substances, most of them with antioxidant properties. PMID:23408945

  6. Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis.

    PubMed

    Deutsch, Gail; Muralidhar, Akshay; Le, Ellen; Borbon, Ivan A; Erickson, Robert P

    2016-03-10

    We have studied the pathophysiology of lung disease which occurs in two mouse models of Niemann-Pick C1 disease. We utilized Npc1(-/-) mice transgenic for normal gene expression in glia or neurons and glia at ages several fold the usual and a mouse model of the juvenile form of NPC1, a point mutation, at one age to confirm some findings. Lung weights, as per cent of body weight, increase much more than liver and spleen weights. Although pulmonary function parameters only vary for hysteresis between young and older Npc1(-/-) mice, they are markedly different than those found in normal control mice. Cholesterol accumulation continued in the older mice but sphingosine-1-phosphate was not increased. Bronchoalveolar lavage (BAL) showed a massive increase (26×) in the number of macrophages. Histologic examination from the older, transgenic Npc1(-/-) mice showed small foci of alveolar proteinosis and evidence of hemorrhage, as well as dense macrophage accumulation. A large subset of macrophages was immunopositive for Fizz1 or arginase-1, markers of the alternative activation pathway, while no Fizz1 or arginase-1 positive macrophages were found in wild-type mice. The percentage of marker positive macrophages was relatively stable at 5-10% at various ages and within the 2 transgenic models. Phosphohistone H3 and Ki67 showed low levels of proliferation of these macrophages. Apoptosis was prominent within lung capillary endothelial cells, but limited within macrophages. Thus, activation of the alternative pathway is involved in Niemann-Pick C1 associated pulmonary macrophage accumulation, with low proliferation of these cells balanced by low levels of apoptosis. PMID:26707209

  7. DAVIC activities

    NASA Astrophysics Data System (ADS)

    Fujiwara, Hiroshi

    1995-12-01

    DAVIC (Digital Audio Visual Council) is the defacto standardization organization established in Mar. 1994, based on international consensus for digital audio visual services. After completion of MPEG2 standardization, the broadcasting industry, the communication industry, the computer industry, and consumer electronics industry have started development of concrete services and products. Especially the interactive digital audio visual services, such as Video On Demand (VOD) or Near Video On Demand (NVOD), have become hot topics all over the world. Such interactive digital audio visual services are combined technologies of multi-media coding, digital transmission and computer networking. Therefore more than 150 organizations from all industry sectors have participated in DAVIC and are contributing from their own industrial contexts. DAVIC's basic policy is to use the available technologies specified by the other standards bodies as much as possible. So DAVIC's standardization activities have close relationship with ISO IEC/JTC1/SC29, ITU-T SG 9, ATM-Forum, IETF, IMA, DVB, etc. DAVIC is trying to specify Applications, Reference Models, Security, Usage Information Control, and the interfaces and protocols among the Content Provider, the Server, the core network, the access network, and the Set Top Unit. DAVIC's first goal is to specify DAVIC1.0 based on CFP1 (Call for Proposal) and CFP2 by Dec. 1995, and the next direction is under preparation for further progress based on CFP3 and CFP4.

  8. Activities update

    NASA Astrophysics Data System (ADS)

    Smith, Gerald A.

    1994-07-01

    The present report is an update on activities for the second year of funding. Research leading to a detailed characterization of antiproton annihilation in nuclei has resulted in a published analysis of fast deuteron production from carbon and uranium targets. This follows previously reported work and publications by our group on gamma-ray, neutral and charged pion, proton, and neutron production. The deuteron measurements are important to our SHIVA Star antiproton- catalyzed microfission experiment at the Phillips Laboratory, Kirtland AFB, in that they help constrain theoretical models of light nuclei production and subsequent energy deposition in the target. Work continues at SHIVA Star on working fluid formation and target compression for the microfission experiment. Excellent progress has been made, both theoretically and experimentally, on these important aspects of the experiment. The Penn State group, working in collaboration with Los Alamos National Laboratory physicists, trapped and held up to 721,000 antiprotons per beam injection pulse from the LEAR accelerator during July, 1993. This was a crucial step to the ultimate goal of transferring large numbers of antiprotons to the Phillips Laboratory for the antiproton-catalyzed microfission experiment.

  9. Active Segmentation

    PubMed Central

    Mishra, Ajay; Aloimonos, Yiannis

    2009-01-01

    The human visual system observes and understands a scene/image by making a series of fixations. Every fixation point lies inside a particular region of arbitrary shape and size in the scene which can either be an object or just a part of it. We define as a basic segmentation problem the task of segmenting that region containing the fixation point. Segmenting the region containing the fixation is equivalent to finding the enclosing contour- a connected set of boundary edge fragments in the edge map of the scene - around the fixation. This enclosing contour should be a depth boundary. We present here a novel algorithm that finds this bounding contour and achieves the segmentation of one object, given the fixation. The proposed segmentation framework combines monocular cues (color/intensity/texture) with stereo and/or motion, in a cue independent manner. The semantic robots of the immediate future will be able to use this algorithm to automatically find objects in any environment. The capability of automatically segmenting objects in their visual field can bring the visual processing to the next level. Our approach is different from current approaches. While existing work attempts to segment the whole scene at once into many areas, we segment only one image region, specifically the one containing the fixation point. Experiments with real imagery collected by our active robot and from the known databases 1 demonstrate the promise of the approach. PMID:20686671

  10. Sugar beet activities of the USDA-ARS East Lansing conducted in cooperation with Saginaw Research & Extension Center during 2013 (including Project 905)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evaluation and rating plots were planted at the Saginaw Valley Research & Extension Center (SVREC) in Frankenmuth, MI in 2013 that focused on Cercospora leaf spot and Rhizoctonia seedling disease performance of a wide range of Beta vulgaris materials. Leaf spot trials were conducted in conjunction w...

  11. IASS Activity

    NASA Astrophysics Data System (ADS)

    Hojaev, Alisher S.; Ibragimova, Elvira M.

    2015-08-01

    It’s well known, astronomy in Uzbekistan has ancient roots and traditions (e.g., Mirzo Ulugh Beg, Abū al-Rayhān al-Bīrūnī, Abū ‘Abdallāh al-Khwārizmī) and astronomical heritage carefully preserved. Nowadays uzbek astronomers play a key role in scientific research but also in OAD and Decadal Plan activity in the Central Asia region. International Aerospace School (IASS) is an amazing and wonderful event held annually about 30 years. IASS is unique project in the region, and at the beginning we spent the Summer and Winter Schools. At present in the summer camp we gather about 50 teenage and undergraduate students over the country and abroad (France, Malaysia, Turkey, Azerbaijan, Pakistan, Russia, etc.). They are selected on the basis of tests of astronomy and space issues. During two weeks of IASS camp the invited scientists, cosmonauts and astronauts as well as other specialists give lectures and engage in practical exercises with IASS students in astronomy, including daily observations of the Sun and night sky observations with meniscus telescope, space research and exploration, aerospace modelling, preparation and presentation of original projects. This is important that IASS gives not theoretical grounds only but also practically train the students and the hands-on training is the major aims of IASS. Lectures and practice in the field of astronomy carried out with the direct involvement and generous assistance of Uranoscope Association (Paris, France). The current 26-th IASS is planned to held in July 2015.

  12. Extension of the energy range of experimental activation cross-sections data of deuteron induced nuclear reactions on indium up to 50MeV.

    PubMed

    Tárkányi, F; Ditrói, F; Takács, S; Hermanne, A; Ignatyuk, A V

    2015-11-01

    The energy range of our earlier measured activation cross-sections data of longer-lived products of deuteron induced nuclear reactions on indium were extended from 40MeV up to 50MeV. The traditional stacked foil irradiation technique and non-destructive gamma spectrometry were used. No experimental data were found in literature for this higher energy range. Experimental cross-sections for the formation of the radionuclides (113,110)Sn, (116m,115m,114m,113m,111,110g,109)In and (115)Cd are reported in the 37-50MeV energy range, for production of (110)Sn and (110g,109)In these are the first measurements ever. The experimental data were compared with the results of cross section calculations of the ALICE and EMPIRE nuclear model codes and of the TALYS 1.6 nuclear model code as listed in the on-line library TENDL-2014. PMID:26226220

  13. Progressive activation of degradation processes in solid oxide fuel cells stacks: Part I: Lifetime extension by optimisation of the operating conditions

    NASA Astrophysics Data System (ADS)

    Nakajo, Arata; Mueller, Fabian; Brouwer, Jacob; Van herle, Jan; Favrat, Daniel

    2012-10-01

    The degradation of solid oxide fuel cells (SOFC) depends on stack and system design and operation. A methodology to evaluate synergistically these aspects to achieve the lowest production cost of electricity has not yet been developed. A repeating unit model, with as degradation processes the decrease in ionic conductivity of the electrolyte, metallic interconnect corrosion, anode nickel particles coarsening and cathode chromium contamination, is used to investigate the impact of the operating conditions on the lifetime of an SOFC system. It predicts acceleration of the degradation due to the sequential activation of multiple processes. The requirements for the highest system efficiency at start and at long-term differ. Among the selected degradation processes, those on the cathode side here dominate. Simulations suggest that operation at lower system specific power and higher stack temperature can extend the lifetime by a factor up to 10, because the beneficial decrease in cathode overpotential prevails over the higher release of volatile chromium species, faster metallic interconnect corrosion and higher thermodynamic risks of zirconate formation, for maximum SRU temperature below 1150 K. The counter-flow configuration, combined with the beneficial effect of internal reforming on lowering the parasitic air blower consumption, similarly yields longer lifetime than co-flow.

  14. Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009).

    PubMed

    Beaton, Alan A; Kaack, Imogen H; Corr, Philip J

    2015-01-01

    The Annett Hand Preference Questionnaire (AHPQ) as modified by Briggs and Nebes was administered along with Carver and White's behavioural inhibition system (BIS) and behavioural activation system (BAS) scale and a shortened form of the Big Five personality questionnaire to 92 university students. After eliminating the data from five respondents who reported having changed handedness and one outlier, there was a significant sex difference in mean BIS scores, with females (n = 43) scoring higher than males (n = 43). Replicating the results of Wright, Hardie and Wilson, non-right-handers (n = 36) had significantly higher mean BIS score than right-handers (n = 50). Controlling for sex of participant, neuroticism and BAS sub-scale scores in hierarchical regression analyses left this BIS effect substantially unaffected. There was no handedness or sex difference on any of the three BAS sub-scales. Further analyses revealed no association between strength, as distinct from direction, of handedness and BIS (or BAS) scores. The findings are discussed with reference to recent developments in reinforcement sensitivity theory on which BIS/BAS variables are based. PMID:25697855

  15. Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.

    PubMed

    Pérez-Núñez, Ramón; Barraza, Natalia; Gonzalez-Jamett, Arlek; Cárdenas, Ana Maria; Barnier, Jean-Vianney; Caviedes, Pablo

    2016-07-01

    In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as altered neuronal function in DS. Lately, the disruption of cellular signaling and regulatory pathways has been implicated in DS pathophysiology, and many of such pathways may represent common targets for diverse DS-related genes, which could in turn represent attractive therapeutical targets. In this regard, one DS-related gene Down Syndrome Cell Adhesion Molecule (DSCAM), has important functions in neuronal proliferation, maturation, and synaptogenesis. p21-associated kinases (PAKs) appear as a most interesting possibility for study, as DSCAM is known to regulate the PAKs pathway. Hence, in DS, overexpressed DSCAM could deregulate PAKs activity and affect signaling pathways that regulate synaptic plasticity such as dendritic spine dynamics and axon guidance and growth. In the present work, we used an immortalized cell line derived from the cerebral cortex of an animal model of DS such as the trisomy 16 (Ts16) fetal mouse (named CTb), and a similar cell line established from a normal littermate (named CNh), to study the effect of DSCAM in the PAKs pathway. The present study shows that DSCAM is overexpressed in CTb cells by approximately twofold, compared to CNh cells. Congruently, PAK1, as well as its downstream effectors LIMK and cofilin, stay phosphorylated for longer periods after DSCAM activation in the CTb cells, leading to an altered actin dynamics, expressed as an increased basal F/G ratio and reduced neurite growth, in the trisomic condition. The present work presents the correlation between DSCAM gene overexpression and a dysregulation of the PAK pathway, resulting in altered morphological parameters of neuronal plasticity in the trisomic cell

  16. Activation Energy

    NASA Technical Reports Server (NTRS)

    Gadeken, Owen

    2002-01-01

    Teaming is so common in today's project management environment that most of us assume it comes naturally. We further assume that when presented with meaningful and challenging work, project teams will naturally engage in productive activity to complete their tasks. This assumption is expressed in the simple (but false) equation: Team + Work = Teamwork. Although this equation appears simple and straightforward, it is far from true for most project organizations whose reality is a complex web of institutional norms based on individual achievement and rewards. This is illustrated by the very first successful team experience from my early Air Force career. As a young lieutenant, I was sent to Squadron Officer School, which was the first in the series of Air Force professional military education courses I was required to complete during my career. We were immediately formed into teams of twelve officers. Much of the course featured competition between these teams. As the most junior member of my team, I quickly observed the tremendous pressure to show individual leadership capability. At one point early in the course, almost everyone in our group was vying to become the team leader. This conflict was so intense that it caused us to fail miserably in our first outdoor team building exercise. We spent so much time fighting over leadership that we were unable to complete any of the events on the outdoor obstacle course. This complete lack of success was so disheartening to me that I gave our team little hope for future success. What followed was a very intense period of bickering, conflict, and even shouting matches as our dysfunctional team tried to cope with our early failures and find some way to succeed. British physician and researcher Wilfred Bion (Experiences in Groups, 1961) discovered that there are powerful psychological forces inherent in all groups that divert from accomplishing their primary tasks. To overcome these restraining forces and use the potential

  17. Rheology of Active Gels

    NASA Astrophysics Data System (ADS)

    Chen, Daniel

    2015-03-01

    Active networks drive a diverse range of critical processes ranging from motility to division in living cells, yet a full picture of their rheological capabilities in non-cellular contexts is still emerging, e.g., How does the rheological response of a network capable of remodeling under internally-generated stresses differ from that of a passive biopolymer network? In order to address this and other basic questions, we have engineered an active gel composed of microtubules, bidirectional kinesin motors, and molecular depletant that self-organizes into a highly dynamic network of active bundles. The network continually remodels itself under ATP-tunable cycles of extension, buckling, fracturing, and self-healing. Using confocal rheometry we have simultaneously characterized the network's linear and non-linear rheological responses to shear deformation along with its dynamic morphology. We find several surprising and unique material properties for these active gels; most notably, rheological cloaking, the ability of the active gel to drive large-scale fluid mixing over several orders of flow magnitude while maintaining an invariant, solid-like rheological profile and spontaneous flow under confinement, the ability to exert micro-Newton forces to drive persistent directed motion of the rheometer tool. Taken together, these results and others to be discussed highlight the rich stress-structure-dynamics relationships in this class of biologically-derived active gels.

  18. Classroom Activity Connections: Lessons from Fluorescence

    ERIC Educational Resources Information Center

    MacCormac, Aoife; O'Brien, Emma; O'Kennedy, Richard

    2010-01-01

    This Classroom Activity Connections paper describes an extension to the "JCE" Classroom Activity #68 "Turning on the Light". A number of additional common items that display fluorescence under UV light are described, including fruits, vegetables, and seashells. Two classroom extensions on fluorescence are also described. From these activities,…

  19. Venus Express Measurement of ULF and ELF Signals in the Venus Ionosphere: Evidence for Extensive Electrical Activity in the Venus Atmosphere

    NASA Astrophysics Data System (ADS)

    Hart, R.; Russell, C. T.; Leinweber, H.; Zhang, T.

    2013-05-01

    Even though the surface of Venus is currently very dry, the atmosphere has extensive cloud cover. These clouds contain sulfuric acid particles that have properties sufficiently similar to water-ice that they would be expected to become charged, as in terrestrial clouds. Also the nitric oxide content of the Venus atmosphere, which is formed by lightning on Earth is similar to the terrestrial values. Thus it is not surprising that numerous manifestations of lightning on Venus have been reported. In this paper we use the Venus Express magnetic measurements to extend our understanding of Venus lightning. The gradiometer magnetometer configuration installed on Venus Express allows the cleaning of the data up to 6 KHz. We exploit these data in the second year of operation to add statistics to our existing data base. We show how ULF and ELF signals appear to reach the spacecraft via different paths but could have the same physical cause: electrical discharges in the Venus ionosphere.

  20. Control of Polarized Growth by the Rho Family GTPase Rho4 in Budding Yeast: Requirement of the N-Terminal Extension of Rho4 and Regulation by the Rho GTPase-Activating Protein Bem2

    PubMed Central

    Gong, Ting; Liao, Yuan; He, Fei; Yang, Yang; Yang, Dan-Dan; Chen, Xiang-Dong

    2013-01-01

    In the budding yeast Saccharomyces cerevisiae, Rho4 GTPase partially plays a redundant role with Rho3 in the control of polarized growth, as deletion of RHO4 and RHO3 together, but not RHO4 alone, caused lethality and a loss of cell polarity at 30°C. Here, we show that overexpression of the constitutively active rho4Q131L mutant in an rdi1Δ strain caused a severe growth defect and generated large, round, unbudded cells, suggesting that an excess of Rho4 activity could block bud emergence. We also generated four temperature-sensitive rho4-Ts alleles in a rho3Δ rho4Δ strain. These mutants showed growth and morphological defects at 37°C. Interestingly, two rho4-Ts alleles contain mutations that cause amino acid substitutions in the N-terminal region of Rho4. Rho4 possesses a long N-terminal extension that is unique among the six Rho GTPases in the budding yeast but is common in Rho4 homologs in other yeasts and filamentous fungi. We show that the N-terminal extension plays an important role in Rho4 function since rho3Δ rho4Δ61 cells expressing truncated Rho4 lacking amino acids (aa) 1 to 61 exhibited morphological defects at 24°C and a growth defect at 37°C. Furthermore, we show that Rho4 interacts with Bem2, a Rho GTPase-activating protein (RhoGAP) for Cdc42 and Rho1, by yeast two-hybrid, bimolecular fluorescence complementation (BiFC), and glutathione S-transferase (GST) pulldown assays. Bem2 specifically interacts with the GTP-bound form of Rho4, and the interaction is mediated by its RhoGAP domain. Overexpression of BEM2 aggravates the defects of rho3Δ rho4 mutants. These results suggest that Bem2 might be a novel GAP for Rho4. PMID:23264647

  1. Physical Activity (Exercise)

    MedlinePlus

    ... fitness. Your fitness routine should include aerobic and strength-training activities, and may also include stretching activities. Aerobic ... Examples include walking, jogging, bicycling, swimming, and tennis. Strength-training activities These activities increase the strength and endurance ...

  2. Numerical Modeling of an Active Salt System in Canyonlands, Utah: The Role of Topography in Driving Plastic Flow and Brittle Extension

    NASA Astrophysics Data System (ADS)

    Kravitz, K.; Upton, P.; Mueller, K. J.

    2014-12-01

    The Needles District of Canyonlands, Utah contains a coupled array of extensional faults, salt diapirs and an elongate anticline produced by gravitational stresses associated with erosion and canyon cutting along the Colorado River and its tributaries. Three-dimensional numerical models using high-resolution topography have been produced using FLAC3D to test how plastic flow of evaporites and brittle extension of overburden are coupled during deformation and how they combine to form salt structures in the region. High resolution (50 m DEM) topographic models were built of the Needles District and of the region to the southwest of the Needles containing the Imperial Valley fault. The overburden in these models was described by a strain-softening Mohr-Coulomb rheology and is 400 m thick from the surface to the base of the Colorado River canyon. It overlays a flat, 340 m thick, viscous layer representing the salt, which outcrops in the Colorado river downstream of the grabens. The Needles District is dominated by horst and graben structures which extend updip from the Colorado River to the southeast. In models of the Needles, lateral displacement is dominantly to the northwest, toward the river canyon with the most displacement occurring in regions containing side canyons. In the canyon, salt flows upward to form an anticline that follows the sinuosity of the river, and diapirs appear adjacent to side canyons or where the canyon widens, which is observed in the field and the models. Without a salt layer, models show much smaller displacement rates that vary from northwest to southeast demonstrating the importance of a flat lying salt layer in propagating deformation toward the river. The region to the southwest is an area of broader subsidence bounded by a major fault (Imperial Valley fault) with fewer developed extensional faults near the river canyon. The Imperial Valley fault model shows similar patterns in which deformation is driven perpendicular to the river

  3. Forecasting geomagnetic activity indices

    NASA Astrophysics Data System (ADS)

    Schofield, J.; Wing, S.; Johnson, J. R.

    2007-12-01

    Magnetically active times, e.g., Kp > 5, are notoriously difficult to predict, precisely the times when such predictions are crucial to the space weather users. Taking advantage of the routinely available solar wind measurements at Langrangian point (L1) and nowcast Kps, Kp and Dst forecast models based on neural networks were developed with the focus on improving the forecast for active times. To satisfy different needs and operational constraints, three models were developed: (1) a model that inputs nowcast Kp and solar wind parameters and predicts Kp 1 hr ahead; (2) a model with the same input as model 1 and predicts Kp 4 hr ahead; and (3) a model that inputs only solar wind parameters and predicts Kp 1 hr ahead (the exact prediction lead time depends on the solar wind speed and the location of the solar wind monitor.) Extensive evaluations of these models and other major operational Kp forecast models show that, while the new models can predict Kps more accurately for all activities, the most dramatic improvements occur for moderate and active times. Similar Dst models were developed. Information dynamics analysis of Kp, suggests that geospace is more dominated by internal dynamics near solar minimum than near solar maximum, when it is more directly driven by external inputs, namely solar wind and interplanetary magnetic field (IMF).

  4. [Adapting physical activities for an active retirement].

    PubMed

    Renaudie, François

    2016-01-01

    The benefits of doing adapted physical exercise for elderly people have been proven. For more than thirty years, the French Federation for an Active Retirement has been striving to help people age well by proposing multiple activities to remain in good health after the age of 50. Doctors, activity leaders and federal instructors are attentive to each individual's capacities. PMID:27449307

  5. 200 Outdoor Science Activities, A Classroom Extension.

    ERIC Educational Resources Information Center

    Ontario Teachers' Federation, Toronto.

    To encourage teachers to use the out-of-doors in their teaching, this booklet has been prepared by the Ontario Teachers' Federation. It reviews basic approaches to out-of-doors instruction, types of field trips, teacher training and sources of instructional assistance, pre-planning and follow-up for a field trip, and points to consider in…

  6. Learning as Activity.

    ERIC Educational Resources Information Center

    Jonassen, David H.

    2002-01-01

    Integrates contemporary theories of learning into a theory of learning as activity. Explains ecological psychology, changes in understanding of learning, activity systems and activity theory (including the integration of consciousness and activity), and activity structure; and discusses learning as a cognitive and social process. (LRW)

  7. Coagulant Activity of Leukocytes. TISSUE FACTOR ACTIVITY

    PubMed Central

    Niemetz, J.

    1972-01-01

    Peritoneal leukocytes harvested from rabbits which have received two spaced doses of endotoxin have significantly greater (10-fold) coagulant activity than leukocytes from control rabbits. The coagulant activity accelerates the clotting of normal plasma and activates factor X in the presence of factor VII and calcium and is therefore regarded as tissue factor. A total of 40-80 mg tissue factor activity was obtained from the peritoneal cavity of single endotoxin-treated rabbits. In leukocyte subcellular fractions, separated by centrifugation, the specific tissue factor activity sedimented mainly at 14,500 g and above. The procoagulant activity was destroyed after heating for 10 min at 65°C but was preserved at lower temperatures. Polymyxin B, when given with the first dose of endotoxin, reduced both the number of peritoneal leukocytes and their tissue factor activity by two-thirds. When given immediately before the second dose of endotoxin, polymyxin B had no inhibitory effect. PMID:4333021

  8. Facts about Physical Activity

    MedlinePlus

    ... Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Facts about Physical Activity ... Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs File Formats Help: How ...

  9. Physical Activity Assessment

    Cancer.gov

    Current evidence convincingly indicates that physical activity reduces the risk of colon and breast cancer. Physical activity may also reduce risk of prostate cancer. Scientists are also evaluating potential relationships between physical activity and other cancers.

  10. Active oxide nanophotonics

    NASA Astrophysics Data System (ADS)

    Dicken, Matthew J.

    Materials that can be manipulated electrically or mechanically to induce a change in their intrinsic properties are highly relevant when suitably integrated with current technologies. These "active" materials, such as oxide-based ferroelectrics or materials with easily accessible changes of phase, find extensive use as mechanical resonators, solid-state memories, and optical modulators. Barium titanate, a tetragonal ferroelectric at room temperature, is a prime example of a material both mechanically and optically active. This thesis deals primarily with the deposition of active, oxide-based materials and their integration into device structures where either the mechanical or optical properties are exploited. The technologically interesting paradigms within which these active oxide materials have been investigated are microelectromechanical systems, plasmonics, and metamaterials. Microelectromechanical systems are devices that have been micromachined and rely on an applied voltage to induce a mechanical response. Mechanically active materials, such as piezoelectrics or ferroelectrics, can increase the response of these devices. Plasmonics deals with electromagnetic waves resonantly coupled into free electron oscillations at a metal-dielectric interface or metal nanoparticle. Coupling to these resonant modes allows surface plasmon polaritons to propagate along the metal with a nonlinear dispersion. Metamaterials are ordered, subwavelength, metal inclusions in a dielectric, which respond collectively to electromagnetic radiation. This response can yield a material permittivity or permeability not found in nature. The optical properties of metamaterials lead to effects such as negative index response and super lensing, and can be used to design optical cloaking structures. Here, devices utilizing these effects are investigated with an eye toward tuning or switching their resonant response using optically active oxide thin films. This manuscript follows the evolution

  11. Adapting Active Learning in Ethiopia

    ERIC Educational Resources Information Center

    Casale, Carolyn Frances

    2010-01-01

    Ethiopia is a developing country that has invested extensively in expanding its educational opportunities. In this expansion, there has been a drastic restructuring of its system of preparing teachers and teacher educators. Often, improving teacher quality is dependent on professional development that diversifies pedagogy (active learning). This…

  12. Lightning activity on Jupiter

    NASA Technical Reports Server (NTRS)

    Borucki, W. J.; Bar-Nun, A.; Scarf, F. L.; Look, A. F.; Hunt, G. E.

    1982-01-01

    Photographic observations of the nightside of Jupiter by the Voyager 1 spacecraft show the presence of extensive lightning activity. Detection of whistlers by the plasma wave analyzer confirms the optical observations and implies that many flashes were not recorded by the Voyager camera because the intensity of the flashes was below the threshold sensitivity of the camera. Measurements of the optical energy radiated per flash indicate that the observed flashes had energies similar to that for terrestrial superbolts. The best estimate of the lightning energy dissipation rate of 0.0004 W/sq m was derived from a consideration of the optical and radiofrequency measurements. The ratio of the energy dissipated by lightning compared to the convective energy flux is estimated to be between 0.000027 and 0.00005. The terrestrial value is 0.0001.

  13. Active commuting to school

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Declines in physical activity levels have coincided with increasing rates of obesity in children. This is problematic because physical activity has been shown to attenuate weight gain in children. Active commuting to school is one way of increasing children's physical activity. However, given the hi...

  14. Civil Law: 12 Activities.

    ERIC Educational Resources Information Center

    Dresbach, Debra

    These learning activities on civil law are intended to supplement the secondary level Scholastic materials "Living Law." Case studies, simulations, and role-play activities are included. Information provided for each activity includes a brief overview, background information, teacher instructions and a description of each activity. Activities…

  15. Increasing Youth Physical Activity with Activity Calendars

    ERIC Educational Resources Information Center

    Eckler, Seth

    2016-01-01

    Physical educators often struggle with ways to get their students to be active beyond the school day. One strategy to accomplish this is the use of physical activity calendars (PACs). The purpose of this article is to support the use of PACs and give practical advice for creating effective PACs.

  16. Persistent active longitudes in sunspot activity

    NASA Astrophysics Data System (ADS)

    Berdyugina, S.; Usoskin, I.

    It has been recently shown that spot activity of cool stars including solar analogues, is grouped in two clearly distinguished active longitudes which are persistent within at least one starspot cycle. Solar data including positional information of individual sunspots / groups extends back for about 130 years covering 12 solar cycles. Here we present the results of our research of longitudinal distribution of sunspot activity using an analysis similar to that applied to the stars. First, we synthesized, from the actual sunspot data, the sun's light curve as if it was defined only by spots. Then solar images were calculated from this light curve, giving a natural smoothing of the spot pattern. For each Carrington rotation, longitudinal position of these smoothed spot regions was calculated. The analysis reveals the following main features: - Sunspot activity is grouped in two active longitudes (with the differential rotation taken into account) 180o apart from each other which are persistent through the entire studied period of 12 cycles, similarly to stars. - The longitude migration is determined by changing the mean latitude of sunspot activity (the Maunder butterfly) and differential rotation. - The two longitudes periodically alternate the dominant activity with about 3.7 year period implying for the existence of the Sflip-flopT phenomenon known in - starspot activity.

  17. Acid Rain: Activities for Science Teachers.

    ERIC Educational Resources Information Center

    Johnson, Eric; And Others

    1983-01-01

    Seven complete secondary/college level acid rain activities are provided. Activities include overview; background information and societal implications; major concepts; student objectives; vocabulary/material lists; procedures; instructional strategies; and questions/discussion and extension suggestions. Activities consider effects of acid rain on…

  18. The Active Solid Earth

    NASA Astrophysics Data System (ADS)

    Ebinger, Cynthia

    2016-04-01

    Dynamic processes in Earth's crust, mantle and core shape Earth's surface and magnetic field over time scales of seconds to millennia, and even longer time scales as recorded in the ca. 4 Ga rock record. Our focus is the earthquake-volcano deformation cycles that occur over human time scales, and their comparison with time-averaged deformation studies, with emphasis on mantle plume provinces where magma and volatile release and vertical tectonics are readily detectable. Active deformation processes at continental and oceanic rift and back arc zones provide critical constraints on mantle dynamics, the role of fluids (volatiles, magma, water), and plate rheology. For example, recent studies of the East African rift zone, which formed above one of Earth's largest mantle upwellings reveal that magma production and volatile release rates are comparable to those of magmatic arcs, the archetypal zones of continental crustal creation. Finite-length faults achieve some plate deformation, but magma intrusion in the form of dikes accommodates extension in continental, back-arc, and oceanic rifts, and intrusion as sills causes permanent uplift that modulates the local time-space scales of earthquakes and volcanoes. Volatile release from magma intrusion may reduce fault friction and permeability, facilitating aseismic slip and creating magma pathways. We explore the implications of active deformation studies to models of the time-averaged structure of plume and extensional provinces in continental and oceanic plate settings.

  19. Activity Cycles in Stars with Highly Active Chromospheres

    NASA Astrophysics Data System (ADS)

    Guinan, Edward F.

    The extended lifetime of the IUE satellite has provided an unique and unanticipated opportunity to examine the long-term evolution of magnetic activity on active chromospheric stars. We propose to obtain further IUE observations of the highly active RS CVn stars V711 Tauri, lambda Andromedae, II Pegasi, and UX Arietis in conjunction with groundbased optical and radio observations, and possibly ROSAT X-ray observations. In addition we would continue IUE observations of the unusual rapidly rotating early G giant, FK Comae, which, although not in the RS CVn category, shares a similarly high level of magnetic activity. These five stars have the most extensive IUE archival coverage for stars of their type and have almost continuous ground-based photometric coverage from about 1975 onward. We aim to trace the long-term development of magnetic activity on these stars: a detailed study of the UV emission-like fluxes will enable us to follow the variations in chromospheric and transition-region activity over an interval of 12-16 years. Optical observations reveal variations in photospheric (starspot) activity: the starspot regions are large (up to 30% of the stellar surface) and vary significantly with time. The main aim of the proposed research is to examine the relationship between chromospheric, transition-region, and photospheric active regions. Elucidation of the role of white-light faculae vis-a-vis spots in effecting stellar irradiance changes is also desirable.

  20. Antifeedant activity of quassinoids.

    PubMed

    Leskinen, V; Polonsky, J; Bhatnagar, S

    1984-10-01

    The antifeedant activity of 13 quassinoids of different structural types has been studied against the Mexican bean beetle (Epilachna varivestis Mulsant) 4th instar larvae and the southern armyworm (Spodoptera eridania Crawer) 5th instar larvae. All quassinoids tested displayed significant activity against the Mexican bean beetle and, thus, do not reveal a simple structure-activity relationship. Five quassinoids were active against the southern armyworm. Interestingly, four of these-bruceantin (I), glaucarubinone (VI), isobruceine A (VIII), and simalikalactone D (XI)-possess the required structural features for antineoplastic activity. The noncytotoxic quassin (X) is an exception; it is active against both pests. PMID:24318349

  1. CATALASE ACTIVITY IN LEPTOSPIRA

    PubMed Central

    Rao, P. J.; Larson, A. D.; Cox, C. D.

    1964-01-01

    Rao, P. J. (University of Illinois, Urbana), A. D. Larson, and C. D. Cox. Catalase activity in Leptospira. J. Bacteriol. 88:1045–1048. 1964.—A number of serotypes of Leptospira were found to possess catalase activity, although considerable variation in activity existed among various serotypes. Catalase activity of L. pomona was reduced by inhibitors commonly employed for arresting catalase activity in other biological systems. Catalase activity was increased three to five times by growing cultures under conditions of oxygen availability; however, aeration had no beneficial effect on total viable cell crop. The relationship of oxygen to metabolism and future studies on virulence of the leptospirae is discussed. PMID:14219017

  2. Active Fire Mapping Program

    MedlinePlus

    ... Incidents (Home) New Large Incidents Fire Detection Maps MODIS Satellite Imagery VIIRS Satellite Imagery Fire Detection GIS ... Data Web Services Latest Detected Fire Activity Other MODIS Products Frequently Asked Questions About Active Fire Maps ...

  3. Preschoolers’ Physical Activity Behaviours

    PubMed Central

    Irwin, Jennifer D.; He, Meizi; Bouck, L. Michelle Sangster; Tucker, Patricia; Pollett, Graham L.

    2016-01-01

    Objectives To understand parents’ perspectives of their preschoolers’ physical activity behaviours. Methods A maximum variation sample of 71 parents explored their preschoolers’ physical activity behaviours through 10 semi-structured focus group discussions. Results Parents perceived Canada’s Physical Activity Guidelines for Children as inadequate; that their preschoolers get and need more than 30–90 minutes of activity daily; and that physical activity habits must be established during the preschool years. Nine barriers against and facilitators toward adequate physical activity were proposed: child’s age, weather, daycare, siblings, finances, time, society and safety, parents’ impact, and child’s activity preferences. Discussion The need for education and interventions that address current barriers are essential for establishing physical activity as a lifestyle behaviour during early childhood and, consequently, helping to prevent both childhood and adulthood obesity. PMID:16625802

  4. Balance Food and Activity

    MedlinePlus

    ... For Health Professionals Tools and Resources Promotional Materials Programming Materials Weight Management Nutrition Physical Activity Reduce Screen ... Training For Health Professionals Tools & Resources Promotional ... Programming Materials Weight Management Nutrition Physical Activity Reduce Screen ...

  5. Active magnetic regenerator

    DOEpatents

    Barclay, John A.; Steyert, William A.

    1982-01-01

    The disclosure is directed to an active magnetic regenerator apparatus and method. Brayton, Stirling, Ericsson, and Carnot cycles and the like may be utilized in an active magnetic regenerator to provide efficient refrigeration over relatively large temperature ranges.

  6. Exercise and Physical Activity

    MedlinePlus

    Alzheimer ’s Caregiving Tips Exercise and Physical Activity Being active and getting exercise helps people with Alzheimer’s disease feel better. Exercise helps keep their muscles, joints, and heart in ...

  7. Antimicrobial activity of isopteropodine.

    PubMed

    García, Rubén; Cayunao, Cesia; Bocic, Ronny; Backhouse, Nadine; Delporte, Carle; Zaldivar, Mercedes; Erazo, Silvia

    2005-01-01

    Bioassay-directed fractionation for the determination of antimicrobial activity of Uncaria tomentosa, has led to the isolation of isopteropodine (0.3%), a known Uncaria pentacyclic oxindol alkaloid that exhibited antibacterial activity against Gram positive bacteria. PMID:16042336

  8. Population Education. Awareness Activities.

    ERIC Educational Resources Information Center

    Brouse, Deborah E.

    1990-01-01

    Described are awareness activities that deal with human population growth, resources, and the environment. Activities include simulations, mathematical exercises, and discussions of the topic. Specific examples of what individuals can do to help are listed. (KR)

  9. Major operations and activities

    SciTech Connect

    Black, D.G.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the major operations and activities on the site. These operations and activities include site management, waste management, environmental restoration and corrective actions, and research and technology development.

  10. Family Activities for Fitness

    ERIC Educational Resources Information Center

    Grosse, Susan J.

    2009-01-01

    This article discusses how families can increase family togetherness and improve physical fitness. The author provides easy ways to implement family friendly activities for improving and maintaining physical health. These activities include: walking, backyard games, and fitness challenges.

  11. Active at Any Size

    MedlinePlus

    ... beginners. Daily life activities Lifestyle activities, such as gardening or washing the car, are great ways to ... bags. Doing chores like lawn mowing, raking leaves, gardening, and housework also count. What questions should I ...

  12. WASTE ACTIVATED SLUDGE PROCESSING

    EPA Science Inventory

    A study was made at pilot scale of a variety of processes for dewatering and stabilization of waste activated sludge from a pure oxygen activated sludge system. Processes evaluated included gravity thickening, dissolved air flotation thickening, basket centrifugation, scroll cent...

  13. Green Schools Activity Booklet.

    ERIC Educational Resources Information Center

    Sacramento Tree Foundation, CA.

    This collection of interdisciplinary hands-on activities covers a variety of topics related to trees and conservation. Twenty-four activities integrate the subjects of social studies, fine arts, science, language arts, math, geography, and music. Although activity instructions are not consistent they usually contain details on objectives and…

  14. Technology Systems. Laboratory Activities.

    ERIC Educational Resources Information Center

    Brame, Ray; And Others

    This guide contains 43 modules of laboratory activities for technology education courses. Each module includes an instructor's resource sheet and the student laboratory activity. Instructor's resource sheets include some or all of the following elements: module number, course title, activity topic, estimated time, essential elements, objectives,…

  15. Climate Change: An Activity.

    ERIC Educational Resources Information Center

    Lewis, Garry

    1995-01-01

    Presents a segment of the Geoscience Education booklet, Climate Change, that contains information and activities that enable students to gain a better appreciation of the possible effects human activity has on the Earth's climate. Describes the Terrace Temperatures activity that leads students through an investigation using foraminifera data to…

  16. Bonus Activity Book.

    ERIC Educational Resources Information Center

    Learning, 1992

    1992-01-01

    Provides on-task activities to fill in unexpected extra moments in elementary classes. The activities require little preparation and take 5-15 minutes to complete. There are activities for math, language arts, social science, science, critical thinking, and computer. An outer space board game is also included. (SM)

  17. Activity Sheets. Draft Copy.

    ERIC Educational Resources Information Center

    Duke Power Company, Educational Services Dept., Charlotte, NC.

    This document consists of energy vocabulary activities, three games, worksheets, laboratory activities/exercises, and an introductory classroom exercise designed to introduce energy concepts to students. Vocabulary activities focus on coal and energy consumption. The three games (with instructions) focus on various aspects of energy and energy…

  18. Hepatitis and activity

    PubMed Central

    Krikler, Dennis M.

    1971-01-01

    The effects of physical activity during an attack of infectious hepatitis are discussed. There is no evidence that activity during convalescence produces any ill-effects. On the other hand, strenuous physical activity in the acute stage may be dangerous, possibly because hepatic blood-flow is reduced. PMID:5560143

  19. Measurement of Physical Activity.

    ERIC Educational Resources Information Center

    Dishman, Rod K.; Washburn, Richard A.; Schoeller, Dale A.

    2001-01-01

    Valid assessment of physical activity must be unobtrusive, practical to administer, and specific about physical activity type, frequency, duration, and intensity. Assessment methods can be categorized according to whether they provide direct or indirect (e.g., self-report) observation of physical activity, body motion, physiological response…

  20. Activity Theory and Ontology

    ERIC Educational Resources Information Center

    Peim, Nick

    2009-01-01

    This paper seeks to re-examine Yrio Engestrom's activity theory as a technology of knowledge designed to enable positive transformations of specific practices. The paper focuses on a key paper where Engestrom defines the nature and present state of activity theory. Beginning with a brief account of the relations between activity theory and…

  1. Technology Learning Activities I.

    ERIC Educational Resources Information Center

    International Technology Education Association, Reston, VA.

    This guide contains 30 technology learning activities. Activities may contain all or some of the following: an introduction, objectives, materials and equipment, challenges, limitations, notes and investigations, resources and references used, and evaluation ideas. Activity titles are: (1) Occupations in Construction Technology; (2) Designing a…

  2. Woodsy Owl Activity Guide.

    ERIC Educational Resources Information Center

    Forest Service (USDA), Washington, DC.

    This guide offers teachers and after-school group leaders 12 fun and engaging activities. Activities feature lessons on trees, water, wind, the earth, food, and waste. The activities are designed to help children aged 5-8 become more aware of the natural environment and fundamental conservation principles. Titles of children's books are embedded…

  3. FLES Games and Activities.

    ERIC Educational Resources Information Center

    Irujo, Suzanne, Ed.

    A number of activities for teaching foreign language in the elementary school (FLES) are presented. The activities were developed by participants in a FLES teacher training workshop, Project INTERACT, in the Boston area. The first section contains games, thematic units, and other activities specifically related to French language instruction,…

  4. FL Activities & Festivals.

    ERIC Educational Resources Information Center

    American Council on the Teaching of Foreign Languages, Hastings-on-Hudson, NY.

    A collection of student, class, and school foreign language activities suggests a variety of projects and describes three specific school efforts. The suggested activities include: (1) individual student efforts such as writing to pen-pals; (2) group activities such as a foreign language auction or sing-along; (3) group projects for the school…

  5. Highlights of 1981 activities

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The highlights of NASA's 1981 activities are presented, including the results of the two flights of the space shuttle Columbia and the Voyager 2 encounter with Saturn. Accomplishments in the areas of space transportation operations; space science; aeronautical, energy, and space research and development; as well as space tracking, international activities, and 1981 launch activities are discussed.

  6. Anticancer activity of ferrocenylthiosemicarbazones.

    PubMed

    Sandra, Cortez-Maya; Elena, Klimova; Marcos, Flores-Alamo; Elena, Martínez-Klimova; Arturo, Ramírez-Ramírez; Teresa, Ramírez Apan; Marcos, Martínez-García

    2014-03-01

    Aliphatic and aromatic ferrocenylthiosemicarbazones were synthesized. The characterization of the new ferrocenylthiosemicarbazones was done by IR, (1)H-NMR and (13)C-NMR spectroscopy, elemental analysis and X-ray diffraction studies. The biological activity of the obtained compounds was assessed in terms of anticancer activity. Their activity against U251 (human glyoblastoma), PC-3 (human prostatic adenocarcinoma), K562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma) and SKLU-1 (human lung adenocarcinoma) cell lines was studied and compared with cisplatin. All tested compounds showed good activity and the aryl-chloro substituted ferrocenylthiosemicarbazones showed the best anticancer activity. PMID:24144199

  7. Transcriptional activators in yeast

    PubMed Central

    2006-01-01

    Eukaryotic transcription activation domains (ADs) are not well defined on the proteome scale. We systematicallly tested ∼6000 yeast proteins for transcriptional activity using a yeast one-hybrid system and identified 451 transcriptional activators. We then determined their transcription activation strength using fusions to the Gal4 DNA-binding domain and a His3 reporter gene which contained a promoter with a Gal4-binding site. Among the 132 strongest activators 32 are known transcription factors while another 35 have no known function. Although zinc fingers, helix–loop–helix domains and several other domains are highly overrepresented among the activators, only few contain characterized ADs. We also found some striking correlations: the stronger the activation activity, the more acidic, glutamine-rich, proline-rich or asparagine-rich the activators were. About 29% of the activators have been found previously to specifically interact with the transcription machinery, while 10% are known to be components of transcription regulatory complexes. Based on their transcriptional activity, localization and interaction patterns, at least six previously uncharacterized proteins are suggested to be bona fide transcriptional regulators (namely YFL049W, YJR070C, YDR520C, YGL066W/Sgf73, YKR064W and YCR082W/Ahc2). PMID:16464826

  8. Vestibular activation of sympathetic nerve activity

    NASA Technical Reports Server (NTRS)

    Ray, C. A.; Carter, J. R.

    2003-01-01

    AIM: The vestibulosympathetic reflex refers to sympathetic nerve activation by the vestibular system. Animal studies indicate that the vestibular system assists in blood pressure regulation during orthostasis. Although human studies clearly demonstrate activation of muscle sympathetic nerve activity (MSNA) during engagement of the otolith organs, the role of the vestibulosympathetic reflex in maintaining blood pressure during orthostasis is not well-established. Examination of the vestibulosympathetic reflex with other cardiovascular reflexes indicates that it is a powerful and independent reflex. Ageing, which is associated with an increased risk for orthostatic hypotension, attenuates the vestibulosympathetic reflex. The attenuated reflex is associated with a reduction in arterial pressure. CONCLUSION: These findings suggest that the vestibulosympathetic reflex assists in blood pressure regulation in humans, but future studies examining this reflex in other orthostatically intolerant populations are necessary to address this hypothesis.

  9. Activated carbon from biomass

    NASA Astrophysics Data System (ADS)

    Manocha, S.; Manocha, L. M.; Joshi, Parth; Patel, Bhavesh; Dangi, Gaurav; Verma, Narendra

    2013-06-01

    Activated carbon are unique and versatile adsorbents having extended surface area, micro porous structure, universal adsorption effect, high adsorption capacity and high degree of surface reactivity. Activated carbons are synthesized from variety of materials. Most commonly used on a commercial scale are cellulosic based precursors such as peat, coal, lignite wood and coconut shell. Variation occurs in precursors in terms of structure and carbon content. Coir having very low bulk density and porous structure is found to be one of the valuable raw materials for the production of highly porous activated carbon and other important factor is its high carbon content. Exploration of good low cost and non conventional adsorbent may contribute to the sustainability of the environment and offer promising benefits for the commercial purpose in future. Carbonization of biomass was carried out in a horizontal muffle furnace. Both carbonization and activation were performed in inert nitrogen atmosphere in one step to enhance the surface area and to develop interconnecting porosity. The types of biomass as well as the activation conditions determine the properties and the yield of activated carbon. Activated carbon produced from biomass is cost effective as it is easily available as a waste biomass. Activated carbon produced by combination of chemical and physical activation has higher surface area of 2442 m2/gm compared to that produced by physical activation (1365 m2/gm).

  10. Marine Biology Activities. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Pauls, John

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  11. 75 FR 53982 - Proposed Information Collection Request of the ETA 207, Nonmonetary Determination Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... Determination Activities Report; Comment Request on Extension Without Change (OMB 1205-0150) AGENCY: Employment... . SUPPLEMENTARY INFORMATION: I. Background: The ETA 207 Report, Nonmonetary Determination Activities, contains... proposed extension collection of the ETA 207, Nonmonetary Determinations Activities Report. Comments...

  12. Patterns in Active Nematics

    NASA Astrophysics Data System (ADS)

    Yeomans, Julia M.

    Active systems, from bacterial suspensions to cellular monolayers, are continuously driven out of equilibrium by local injection of energy from their constituent elements and exhibit turbulent-like, chaotic patterns. We describe how active systems can be stabilised by tuning a physical feature of the system, friction. We demonstrate how the crossover between wet active systems, whose behaviour is dominated by hydrodynamics, and dry active matter where any flow is screened, can be achieved by using friction as a control parameter and demonstrate vortex ordering at the wet-dry crossover. We show that the self organisation of vortices into lattices is accompanied by the spatial ordering of topological defects leading to active crystal-like structures. The emergence of vortex lattices which leads to the positional ordering of topological defects may be a useful step towards the design and control of active materials.

  13. Stochastic thermodynamics for active matter

    NASA Astrophysics Data System (ADS)

    Speck, Thomas

    2016-05-01

    The theoretical understanding of active matter, which is driven out of equilibrium by directed motion, is still fragmental and model oriented. Stochastic thermodynamics, on the other hand, is a comprehensive theoretical framework for driven systems that allows to define fluctuating work and heat. We apply these definitions to active matter, assuming that dissipation can be modelled by effective non-conservative forces. We show that, through the work, conjugate extensive and intensive observables can be defined even in non-equilibrium steady states lacking a free energy. As an illustration, we derive the expressions for the pressure and interfacial tension of active Brownian particles. The latter becomes negative despite the observed stable phase separation. We discuss this apparent contradiction, highlighting the role of fluctuations, and we offer a tentative explanation.

  14. Synopsis of Cathode #4 Activation

    SciTech Connect

    Kwan, Joe; Ekdahl, C.; Harrison, J.; Kwan, J.; Leitner, M.; McCruistian, T.; Mitchell, R.; Prichard, B.; Roy, P.

    2006-05-26

    The purpose of this report is to describe the activation of the fourth cathode installed in the DARHT-II Injector. Appendices have been used so that an extensive amount of data could be included without danger of obscuring important information contained in the body of the report. The cathode was a 612 M type cathode purchased from Spectra-Mat. Section II describes the handling and installation of the cathode. Section III is a narrative of the activation based on information located in the Control Room Log Book supplemented with time plots of pertinent operating parameters. Activation of the cathode was performed in accordance with the procedure listed in Appendix A. The following sections provide more details on the total pressure and constituent partial pressures in the vacuum vessel, cathode heater power/filament current, and cathode temperature.

  15. Thermally Activated Driver

    NASA Technical Reports Server (NTRS)

    Kinard, William H.; Murray, Robert C.; Walsh, Robert F.

    1987-01-01

    Space-qualified, precise, large-force, thermally activated driver (TAD) developed for use in space on astro-physics experiment to measure abundance of rare actinide-group elements in cosmic rays. Actinide cosmic rays detected using thermally activated driver as heart of event-thermometer (ET) system. Thermal expansion and contraction of silicone oil activates driver. Potential applications in fluid-control systems where precise valve controls are needed.

  16. Activity in distant comets

    NASA Technical Reports Server (NTRS)

    Luu, Jane X.

    1992-01-01

    Activity in distant comets remains a mystery in the sense that we still have no complete theory to explain the various types of activity exhibited by different comets at large distances. This paper explores the factors that should play a role in determining activity in a distant comet, especially in the cases of comet P/Tempel 2, comet Schwassmann-Wachmann 1, and 2060 Chiron.

  17. Activated recombinant adenovirus proteinases

    DOEpatents

    Anderson, C.W.; Mangel, W.F.

    1999-08-10

    This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described. 29 figs.

  18. Activated recombinant adenovirus proteinases

    DOEpatents

    Anderson, Carl W.; Mangel, Walter F.

    1999-08-10

    This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

  19. Physical Activity and Cancer

    MedlinePlus

    ... of scientists, ranging from experts in basic biological science to those with expertise in community behavioral interventions to increase physical activity. This combination of scientists and expertise will ...

  20. NASA metrication activities

    NASA Technical Reports Server (NTRS)

    Vlannes, P. N.

    1978-01-01

    NASA's organization and policy for metrification, history from 1964, NASA participation in Federal agency activities, interaction with nongovernmental metrication organizations, and the proposed metrication assessment study are reviewed.

  1. Active material based active sealing technology: Part 1. Active seal requirements vs. active material actuator properties

    NASA Astrophysics Data System (ADS)

    Henry, Christopher P.; Carter, William; Herrera, Guillermo A.; McKnight, Geoffrey P.; Browne, Alan L.; Johnson, Nancy L.; Bazzi, Imad F.

    2010-04-01

    Current seals used for vehicle closures/swing panels are essentially flexible, frequently hollow structures whose designs are constrained by numerous requirements, many of them competing, including door closing effort (both air bind and seal compression), sound isolation, prevention of water leaks, and accommodation of variations in vehicle build. This paper documents the first portion of a collaborative research study/exploration of the feasibility of and approaches for using active materials with shape and stiffness changing attributes to produce active seal technologies, seals with improved performance. An important design advantage of an active material approach compared to previous active seal technologies is the distribution of active material regions throughout the seal length, which would enable continued active function even with localized failure. Included as a major focus of this study was the assessment of polymeric active materials because of their potential ease of integration into the current seal manufacturing process. In Part 1 of this study, which is documented in this paper, potential materials were evaluated in terms of their cost, activation mechanisms, and mechanical and actuation properties. Based on these properties, simple designs were proposed and utilized to help determine which materials are best suited for active seals. Shape memory alloys (SMA) and electroactive polymers (EAP) were judged to be the most promising.

  2. Environmental Education Activity Sheets 1-11.

    ERIC Educational Resources Information Center

    Halsey, Clifton F.; And Others

    These activity sheets, developed by personnel of the Agricultural Extension Service of the University of Minnesota, were designed for youth group campers but may be used by other populations and individuals. Each activity sheet focuses on a separate topic: (1) Selecting Suitable Uses for Land, (2) Measuring the Steepness of Land, (3) Determining…

  3. An Active Tutorial on Distance Sampling

    ERIC Educational Resources Information Center

    Richardson, Alice

    2007-01-01

    The technique of distance sampling is widely used to monitor biological populations. This paper documents an in-class activity to introduce students to the concepts and the mechanics of distance sampling in a simple situation that is relevant to their own experiences. Preparation details are described. Variations and extensions to the activity are…

  4. Oriented active shape models.

    PubMed

    Liu, Jiamin; Udupa, Jayaram K

    2009-04-01

    Active shape models (ASM) are widely employed for recognizing anatomic structures and for delineating them in medical images. In this paper, a novel strategy called oriented active shape models (OASM) is presented in an attempt to overcome the following five limitations of ASM: 1) lower delineation accuracy, 2) the requirement of a large number of landmarks, 3) sensitivity to search range, 4) sensitivity to initialization, and 5) inability to fully exploit the specific information present in the given image to be segmented. OASM effectively combines the rich statistical shape information embodied in ASM with the boundary orientedness property and the globally optimal delineation capability of the live wire methodology of boundary segmentation. The latter characteristics allow live wire to effectively separate an object boundary from other nonobject boundaries with similar properties especially when they come very close in the image domain. The approach leads to a two-level dynamic programming method, wherein the first level corresponds to boundary recognition and the second level corresponds to boundary delineation, and to an effective automatic initialization method. The method outputs a globally optimal boundary that agrees with the shape model if the recognition step is successful in bringing the model close to the boundary in the image. Extensive evaluation experiments have been conducted by utilizing 40 image (magnetic resonance and computed tomography) data sets in each of five different application areas for segmenting breast, liver, bones of the foot, and cervical vertebrae of the spine. Comparisons are made between OASM and ASM based on precision, accuracy, and efficiency of segmentation. Accuracy is assessed using both region-based false positive and false negative measures and boundary-based distance measures. The results indicate the following: 1) The accuracy of segmentation via OASM is considerably better than that of ASM; 2) The number of landmarks

  5. Active Flow Control Activities at NASA Langley

    NASA Technical Reports Server (NTRS)

    Anders, Scott G.; Sellers, William L., III; Washburn, Anthony E.

    2004-01-01

    NASA Langley continues to aggressively investigate the potential advantages of active flow control over more traditional aerodynamic techniques. This paper provides an update to a previous paper and describes both the progress in the various research areas and the significant changes in the NASA research programs. The goals of the topics presented are focused on advancing the state of knowledge and understanding of controllable fundamental mechanisms in fluids as well as to address engineering challenges. An organizational view of current research activities at NASA Langley in active flow control as supported by several projects is presented. On-center research as well as NASA Langley funded contracts and grants are discussed at a relatively high level. The products of this research are to be demonstrated either in bench-top experiments, wind-tunnel investigations, or in flight as part of the fundamental NASA R&D program and then transferred to more applied research programs within NASA, DOD, and U.S. industry.

  6. Activating Event Knowledge

    ERIC Educational Resources Information Center

    Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken

    2009-01-01

    An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or…

  7. Endonuclease activity in lipocalins.

    PubMed Central

    Yusifov, T N; Abduragimov, A R; Gasymov, O K; Glasgow, B J

    2000-01-01

    Several lipocalins contain conserved amino acid sequences similar to the phosphodiester bond cleavage domain of sugar non-specific magnesium-dependent nucleases of the Serratia marcescens type. His-89 and Glu-127 of the S. marcescens endonuclease are believed to have a role in the active catalytic site by the attack of a water molecule at the phosphorus atom of the bridging phosphate. Tear lipocalin contains both amino acids in analogous regions, and is active as a nuclease. Two forms of beta-lactoglobulin contain only Glu-134 (analogous to Glu-127 of the Serratia nuclease) yet retain nuclease activity equal to or greater than that of tear lipocalin. However, retinol-binding protein lacks both of these motifs and shows no detectable activity. DNA-nicking activity is decreased by 80% in the mutant of tear lipocalin that replaces Glu-128 but is unchanged by mutations of His-84. The endonuclease activity of tear lipocalin is dependent on the bivalent cations Mg(2+) or Mn(2+) but is decreased at high concentrations of NaCl. These findings indicate that some lipocalins have non-specific endonuclease activity similar in characteristics to the Mg(2+)-dependent nucleases and related to the conserved sequence LEDFXR (where 'X' denotes 'any other residue'), in which the glutamic residue seems to be important for activity. PMID:10769187

  8. Endonuclease activity in lipocalins.

    PubMed

    Yusifov, T N; Abduragimov, A R; Gasymov, O K; Glasgow, B J

    2000-05-01

    Several lipocalins contain conserved amino acid sequences similar to the phosphodiester bond cleavage domain of sugar non-specific magnesium-dependent nucleases of the Serratia marcescens type. His-89 and Glu-127 of the S. marcescens endonuclease are believed to have a role in the active catalytic site by the attack of a water molecule at the phosphorus atom of the bridging phosphate. Tear lipocalin contains both amino acids in analogous regions, and is active as a nuclease. Two forms of beta-lactoglobulin contain only Glu-134 (analogous to Glu-127 of the Serratia nuclease) yet retain nuclease activity equal to or greater than that of tear lipocalin. However, retinol-binding protein lacks both of these motifs and shows no detectable activity. DNA-nicking activity is decreased by 80% in the mutant of tear lipocalin that replaces Glu-128 but is unchanged by mutations of His-84. The endonuclease activity of tear lipocalin is dependent on the bivalent cations Mg(2+) or Mn(2+) but is decreased at high concentrations of NaCl. These findings indicate that some lipocalins have non-specific endonuclease activity similar in characteristics to the Mg(2+)-dependent nucleases and related to the conserved sequence LEDFXR (where 'X' denotes 'any other residue'), in which the glutamic residue seems to be important for activity. PMID:10769187

  9. Activity Book: Ocean Ecology.

    ERIC Educational Resources Information Center

    Learning, 1992

    1992-01-01

    Presents a collection of activities to help elementary students study ocean ecology. The activities have students investigate ocean inhabitants, analyze animal adaptations, examine how temperature and saltiness affect ocean creatures, and learn about safeguarding the sea. Student pages offer reproducible learning sheets. (SM)

  10. Activity Book. Celebrating Diversity.

    ERIC Educational Resources Information Center

    Angell, Pat; And Others

    1993-01-01

    This activity book presents elementary level multicultural books designed to foster self-esteem, understanding, and critical reading skills. It includes a resource list and general discussion boosters for analyzing characters and setting, class activities related to the books, and a student page on character study. (SM)

  11. Active Students in Webinars

    ERIC Educational Resources Information Center

    Kolås, Line; Nordseth, Hugo; Yri, Jørgen Sørlie

    2015-01-01

    To ensure student activity in webinars we have defined 10 learning tasks focusing on production and communication e.g. collaborative writing, discussion and polling, and investigated how the technology supports the learning activities. The three project partners in the VisPed-project use different video-conferencing systems, and we analyzed how it…

  12. PM ACTIVITY PATTERN RESEARCH

    EPA Science Inventory

    Human activity/uptake rate data are necessary to estimate potential human exposure and intake dose to environmental pollutants and to refine human exposure models. Personal exposure monitoring studies have demonstrated the critical role that activities play in explaining and pre...

  13. Activation of fly ash

    DOEpatents

    Corbin, David R.; Velenyi, Louis J.; Pepera, Marc A.; Dolhyj, Serge R.

    1986-01-01

    Fly ash is activated by heating a screened magnetic fraction of the ash in a steam atmosphere and then reducing, oxidizing and again reducing the hydrothermally treated fraction. The activated fly ash can be used as a carbon monoxide disproportionating catalyst useful in the production of hydrogen and methane.

  14. Laboratory Activities in Israel

    ERIC Educational Resources Information Center

    Mamlok-Naaman, Rachel; Barnea, Nitza

    2012-01-01

    Laboratory activities have long had a distinctive and central role in the science curriculum, and science educators have suggested that many benefits accrue from engaging students in science laboratory activities. Many research studies have been conducted to investigate the educational effectiveness of laboratory work in science education in…

  15. Active Healthy Summer

    ERIC Educational Resources Information Center

    Elliott, Eloise

    2005-01-01

    Summer break is almost here for most elementary teachers and students. Warmer weather and additional free time to make choices create more opportunities to be physically active, whether home alone or out with friends and family. This article describes ways by which physical education specialists can encourage students' physical activity by…

  16. Ecological Structure Activity Relationships

    EPA Science Inventory

    Ecological Structure Activity Relationships, v1.00a, February 2009
    ECOSAR (Ecological Structure Activity Relationships) is a personal computer software program that is used to estimate the toxicity of chemicals used in industry and discharged into water. The program predicts...

  17. The Activity of Trypsin

    ERIC Educational Resources Information Center

    Russo, Salvatore F.; Holzman, Tom

    1977-01-01

    Describes an experiment that illustrates the following points concerning the experimental determination of trypsin activity: (1) there is a difference in basing enzyme concentration on weight, absorbance, or active sites; and (2) the method of expressing enzyme concentration determines the value of specific, molecular, and catalytic center…

  18. Obesity, Physical Activity - Children.

    ERIC Educational Resources Information Center

    Gilliam, Thomas B.

    Childhood obesity starts at a very early age, and preventive measures taken early enough may retard the development of fat cells. It appears that physical activity plays an important role in reducing obesity. The activity program must start early, in preschool days. It is felt that screening children for obesity when they first enter school and…

  19. Warm-Up Activities.

    ERIC Educational Resources Information Center

    Mingguang, Yang

    1999-01-01

    Discusses how warm-up activities can help to make the English-as-a-foreign-language classroom a lively and interesting place. Warm-up activities are games carried out at the beginning of each class to motivate students to make good use of class time. (Author/VWL)

  20. Directory of Development Activities.

    ERIC Educational Resources Information Center

    Control Data Corp., Minneapolis, Minn.

    Assembled in a loose leaf notebook, this collection of independent on-the-job activities is designed to facilitate employee development and intended to help improve an organization's performance appraisal system. The on-the-job development activities described derive from job descriptions, performance appraisal forms, and discussions with job…

  1. Active and Healthy Schools

    ERIC Educational Resources Information Center

    Ball, Stephen; Kovarik, Jessica; Leidy, Heather

    2015-01-01

    The Active and Healthy School Program (AHS) can be used to alter the culture and environment of a school to help children make healthier choices. The purpose of this study was to determine the effectiveness of AHS to increase physical activity while decreasing total screen time, increase healthy food choices, and improve knowledge about physical…

  2. Chemical Activities. Teacher Edition.

    ERIC Educational Resources Information Center

    Borgford, Christie L.; Summerlin, Lee R.

    This sourcebook for chemical activities is designed to be used as a student laboratory book for both junior and senior high school students. The student's role as a knowledgeable consumer and informed citizen is stressed. Each activity includes a list of needed materials, procedures, reactions, questions, and notes for the teacher which include…

  3. Rainy Day Activities.

    ERIC Educational Resources Information Center

    Texas Child Care, 1997

    1997-01-01

    Experienced caregivers plan ahead for rainy days. This article describes specific rainy day activities for young children, such as books and crafts to learn about rain (rain in a jar, making a rainbow), simple cooking activities (taffy pull, cinnamon candy tea), and games (mummy wrap, hunt the thimble, rain lotto). (EV)

  4. Reflections on Activity Theory

    ERIC Educational Resources Information Center

    Bakhurst, David

    2009-01-01

    It is sometimes suggested that activity theory represents the most important legacy of Soviet philosophy and psychology. But what exactly "is" activity theory? The canonical account in the West is given by Engestrom, who identifies three stages in the theory's development: from Vygotsky's insights, through Leontiev's articulation of the…

  5. Emotionally Intense Science Activities

    ERIC Educational Resources Information Center

    King, Donna; Ritchie, Stephen; Sandhu, Maryam; Henderson, Senka

    2015-01-01

    Science activities that evoke positive emotional responses make a difference to students' emotional experience of science. In this study, we explored 8th Grade students' discrete emotions expressed during science activities in a unit on Energy. Multiple data sources including classroom videos, interviews and emotion diaries completed at the end of…

  6. Activities: More Calculator Capers.

    ERIC Educational Resources Information Center

    Schmalz, Rosemary

    1983-01-01

    Provided is an activity designed to give grades 7-12 students opportunities to discover numerical patterns and to derive general conclusions from observing data. The activity focuses attention on patterns in products such as 33x34, 333x334, and 3333x3334. Three worksheets and answers are included. (JN)

  7. Vegetable Soup Activities.

    ERIC Educational Resources Information Center

    Shepard, Mary; Shepard, Ray

    Vegetable Soup is a new children's television series whose purpose is to counter the negative and destructive effects of racial isolation. This manual gives detailed instructions for discussion of activities that are presented during the television series such as: crafts, games, recipes, language activities, and children's questions. A list of…

  8. ZOOMsci Activity Guide.

    ERIC Educational Resources Information Center

    Wade, Meredith

    This activity guide is based on the Public Broadcasting System's (PBS) program "ZOOM." It is designed for educators with activities that are categorized into three themes: (1) Things That Go, which includes "Air" which explores air pressure, "Rubber Bands" which discovers the potential energy of rubber bands, "Baking Soda and Vinegar" which…

  9. Science World Activities Book.

    ERIC Educational Resources Information Center

    Wisconsin Academy of Sciences, Arts and Letters, Madison.

    This document consists of three sections. Section I contains 19 activities developed by master teachers for the Science World '84 summer science program. These activities focus on studies involving airplane controls, trash bag kites, computers, meteorology, compass orienteering, soils, aquatic ecosystems, bogs, and others. Objectives, materials…

  10. HUMAN EXPOSURE ACTIVITY PATTERNS

    EPA Science Inventory

    Human activity/uptake rate data are necessary to estimate potential human exposure and intake dose to environmental pollutants and to refine human exposure models. Personal exposure monitoring studies have demonstrated the critical role that activities play in explaining and pre...

  11. Coordinating Shared Activities

    NASA Technical Reports Server (NTRS)

    Clement, Bradley

    2004-01-01

    Shared Activity Coordination (ShAC) is a computer program for planning and scheduling the activities of an autonomous team of interacting spacecraft and exploratory robots. ShAC could also be adapted to such terrestrial uses as helping multiple factory managers work toward competing goals while sharing such common resources as floor space, raw materials, and transports. ShAC iteratively invokes the Continuous Activity Scheduling Planning Execution and Replanning (CASPER) program to replan and propagate changes to other planning programs in an effort to resolve conflicts. A domain-expert specifies which activities and parameters thereof are shared and reports the expected conditions and effects of these activities on the environment. By specifying these conditions and effects differently for each planning program, the domain-expert subprogram defines roles that each spacecraft plays in a coordinated activity. The domain-expert subprogram also specifies which planning program has scheduling control over each shared activity. ShAC enables sharing of information, consensus over the scheduling of collaborative activities, and distributed conflict resolution. As the other planning programs incorporate new goals and alter their schedules in the changing environment, ShAC continually coordinates to respond to unexpected events.

  12. Elementary Environmental Activities.

    ERIC Educational Resources Information Center

    Larson, Robert J.

    This guide presents suggestions for field trips, out-of-doors activities, material for centers, and individualized activities in the teaching of elementary school science and particularly environmental education at the elementary level. The guide includes a section on preparation and procedures for conducting field trips, including sample…

  13. Ten Minute Writing Activities.

    ERIC Educational Resources Information Center

    Markus, Sharyn

    Designed with junior high school students in mind, the activities in this booklet are offered as ways to stimulate interest in writing using as little as ten minutes of class time. The activities are arranged in six sections: (1) developing observation skills and paying attention to details; (2) word play, descriptive words, and word collections…

  14. Activation of fly ash

    DOEpatents

    Corbin, D.R.; Velenyi, L.J.; Pepera, M.A.; Dolhyj, S.R.

    1986-08-19

    Fly ash is activated by heating a screened magnetic fraction of the ash in a steam atmosphere and then reducing, oxidizing and again reducing the hydrothermally treated fraction. The activated fly ash can be used as a carbon monoxide disproportionating catalyst useful in the production of hydrogen and methane.

  15. Peak Longevity Physical Activity

    Cancer.gov

    People who engage in three to five times the recommended minimum level of leisure-time physical activity derive the greatest benefit in terms of mortality reduction when compared with people who do not engage in leisure-time physical activity.

  16. Student Activities. Managing Liability.

    ERIC Educational Resources Information Center

    Bennett, Barbara; And Others

    This monograph suggests ways that college or university administrations can undertake a systematic and careful review of the risks posed by students' activities. Its purpose is to provide guidance in integrating the risk management process into a school's existing approaches to managing student organizations and activities. It is noted that no…

  17. Curriculum Activities on Aging.

    ERIC Educational Resources Information Center

    Schmall, Vicki L.; Benge, Nancy

    This paper contains learning activities on aging for use with elementary, high school, and university students in health, family relationships, social studies, and art courses. The activities are intended to help youth develop a more realistic understanding of the aging process and to become aware of both the problems and benefits associated with…

  18. Aging and Semantic Activation.

    ERIC Educational Resources Information Center

    Howard, Darlene V.

    Three studies tested the theory that long term memory consists of a semantically organized network of concept nodes interconnected by leveled associations or relations, and that when a stimulus is processed, the corresponding concept node is assumed to be temporarily activated and this activation spreads to nearby semantically related nodes. In…

  19. [Field Learning Activities].

    ERIC Educational Resources Information Center

    Nolde Forest Environmental Education Center, Reading, PA.

    Seventy field activities, pertinent to outdoor, environmental studies, are described in this compilation. Designed for elementary and junior high school students, the activities cover many discipline areas--science, social studies, language arts, health, history, mathematics, and art--and many are multidisciplinary in use. Topics range from soil…

  20. Active galactic nuclei

    PubMed Central

    Fabian, Andrew C.

    1999-01-01

    Active galactic nuclei are the most powerful, long-lived objects in the Universe. Recent data confirm the theoretical idea that the power source is accretion into a massive black hole. The common occurrence of obscuration and outflows probably means that the contribution of active galactic nuclei to the power density of the Universe has been generally underestimated. PMID:10220363

  1. Activity in F stars

    NASA Technical Reports Server (NTRS)

    Wolff, Sidney C.; Boesgaard, Ann Merchant; Simon, Theodore

    1986-01-01

    Measurements of He I 5876 A and IUE measurements of chromospheric and transition region lines in a large sample of F-type stars are presented. The data show that activity is detectable in nearly all early F-type stars and differs in several of its characteristics from that typically seen in cooler stars with slow rotation and fully developed convective zones. The onset of activity occurs near B-V = 0.28, which corresponds approximately to spectral type F0 and T(eff) = 7300 K. There is no correlation between the level of activity and the abundances of lithium and beryllium in F stars hotter than T(eff) = 6600 K. All but one of the stars in the 6600-7300 K temperature interval are active. The levels of activity in these stars are independent of Rossby number.

  2. Determinants of Physical Activity in Active and Low-Active, Sixth Grade African-American Youth.

    ERIC Educational Resources Information Center

    Trost, Stewart G.; Pate, Russell R.; Ward, Dianne S.; Saunders, Ruth; Riner, William

    1999-01-01

    Compared determinants of physical activity in active and low-active African-American sixth graders, surveying students and making objective assessments of physical activity over seven days. Results indicated that physical activity self-efficacy, beliefs about physical activity outcomes, involvement in community-based physical activity, perception…

  3. Active optical zoom system

    DOEpatents

    Wick, David V.

    2005-12-20

    An active optical zoom system changes the magnification (or effective focal length) of an optical imaging system by utilizing two or more active optics in a conventional optical system. The system can create relatively large changes in system magnification with very small changes in the focal lengths of individual active elements by leveraging the optical power of the conventional optical elements (e.g., passive lenses and mirrors) surrounding the active optics. The active optics serve primarily as variable focal-length lenses or mirrors, although adding other aberrations enables increased utility. The active optics can either be LC SLMs, used in a transmissive optical zoom system, or DMs, used in a reflective optical zoom system. By appropriately designing the optical system, the variable focal-length lenses or mirrors can provide the flexibility necessary to change the overall system focal length (i.e., effective focal length), and therefore magnification, that is normally accomplished with mechanical motion in conventional zoom lenses. The active optics can provide additional flexibility by allowing magnification to occur anywhere within the FOV of the system, not just on-axis as in a conventional system.

  4. Physical activity and cancer.

    PubMed

    Shephard, R J

    1990-12-01

    Evidence that physical activity may protect against various forms of cancer is examined in relation to occupational demands, leisure activities and participation in sport while at university. The variety of forms of neoplasm and equally varied physical activity histories militate against finding any simple relationship between the risk of malignancy and the individual's physical activity history. Nevertheless, five of seven major occupational studies suggest that a physically active occupation offers some protection against colon cancer, and an application of Bradford Hill's criteria generally supports the causal nature of the relationship between physical inactivity and an increased risk of intestinal neoplasia. However, existing reports are by no means conclusive; there thus remains a need for well-designed epidemiological studies of this issue. Data from one laboratory also suggest that in women a history of active leisure is associated with a reduced prevalence of breast and reproductive system cancers. Physical activity potentially encourages a healthy lifestyle, and it could have more direct effects on certain forms of carcinogenesis (for instance, by a speeding of gastro-intestinal transit, or a moderation of sex hormone levels). However, there are also potential negative effects from some types of exercise, particularly an excessive exposure to ultra-violet light in certain water sports. Since moderate exercise elevates mood and helps to conserve lean tissue, it may finally be a helpful component of treatment after a neoplasm has been diagnosed. PMID:2286478

  5. Active touch sensing

    PubMed Central

    Prescott, Tony J.; Diamond, Mathew E.; Wing, Alan M.

    2011-01-01

    Active sensing systems are purposive and information-seeking sensory systems. Active sensing usually entails sensor movement, but more fundamentally, it involves control of the sensor apparatus, in whatever manner best suits the task, so as to maximize information gain. In animals, active sensing is perhaps most evident in the modality of touch. In this theme issue, we look at active touch across a broad range of species from insects, terrestrial and marine mammals, through to humans. In addition to analysing natural touch, we also consider how engineering is beginning to exploit physical analogues of these biological systems so as to endow robots with rich tactile sensing capabilities. The different contributions show not only the varieties of active touch—antennae, whiskers and fingertips—but also their commonalities. They explore how active touch sensing has evolved in different animal lineages, how it serves to provide rapid and reliable cues for controlling ongoing behaviour, and even how it can disintegrate when our brains begin to fail. They demonstrate that research on active touch offers a means both to understand this essential and primary sensory modality, and to investigate how animals, including man, combine movement with sensing so as to make sense of, and act effectively in, the world. PMID:21969680

  6. Measuring Physical Activity Environments

    PubMed Central

    Sallis, James F.

    2010-01-01

    Physical activity is usually done in specific types of places, referred to as physical activity environments. These often include parks, trails, fitness centers, schools, and streets. In recent years, scientific interest has increased notably in measuring physical activity environments. The present paper provides an historical overview of the contributions of the health, planning, and leisure studies fields to the development of contemporary measures. The emphasis is on attributes of the built environment that can be affected by policies to contribute to the promotion of physical activity. Researchers from health fields assessed a wide variety of built environment variables expected to be related to recreational physical activity. Settings of interest were schools, workplaces, and recreation facilities, and most early measures used direct observation methods with demonstrated inter-observer reliability. Investigators from the city planning field evaluated aspects of community design expected to be related to people’s ability to walk from homes to destinations. GIS was used to assess walkability defined by the 3Ds of residential density, land-use diversity, and pedestrian-oriented designs. Evaluating measures for reliability or validity was rarely done in the planning-related fields. Researchers in the leisure studies and recreation fields studied mainly people’s use of leisure time rather than physical characteristics of parks and other recreation facilities. Although few measures of physical activity environments were developed, measures of aesthetic qualities are available. Each of these fields made unique contributions to the contemporary methods used to assess physical activity environments. PMID:19285214

  7. Emotionally Intense Science Activities

    NASA Astrophysics Data System (ADS)

    King, Donna; Ritchie, Stephen; Sandhu, Maryam; Henderson, Senka

    2015-08-01

    Science activities that evoke positive emotional responses make a difference to students' emotional experience of science. In this study, we explored 8th Grade students' discrete emotions expressed during science activities in a unit on Energy. Multiple data sources including classroom videos, interviews and emotion diaries completed at the end of each lesson were analysed to identify individual student's emotions. Results from two representative students are presented as case studies. Using a theoretical perspective drawn from theories of emotions founded in sociology, two assertions emerged. First, during the demonstration activity, students experienced the emotions of wonder and surprise; second, during a laboratory activity, students experienced the intense positive emotions of happiness/joy. Characteristics of these activities that contributed to students' positive experiences are highlighted. The study found that choosing activities that evoked strong positive emotional experiences, focused students' attention on the phenomenon they were learning, and the activities were recalled positively. Furthermore, such positive experiences may contribute to students' interest and engagement in science and longer term memorability. Finally, implications for science teachers and pre-service teacher education are suggested.

  8. Photocatalytic activity of transition-metal-ion-doped coordination polymer (CP): photoresponse region extension and quantum yields enhancement via doping of transition metal ions into the framework of CPs.

    PubMed

    Xu, Xin-Xin; Cui, Zhong-Ping; Gao, Xin; Liu, Xiao-Xia

    2014-06-21

    To improve photocatalytic activity of a coordination polymer (CP) in the visible light region, five different transition metal ions (Fe(3+), Cr(3+), Ru(3+), Co(2+) and Ni(2+)) were introduced into its framework through an ion-exchange process. Among all the resulting transition metal ion doped coordination polymers (TMI/CPs), the one doped with Fe(3+) took on the most excellent photocatalytic activity and the highest quantum yields in the visible light region, decomposing 94% Rhodamine B (RhB) in 8 hours. It can be attributed to the doping of Fe(3+), which reduced the band gap (Eg) of the original CP, facilitating photocatalysis of the obtained polymer. Compared with the coordination polymer with Fe(3+) as a dopant, products doped with other metal ions presented weaker photocatalytic activities in the visible light region, while under the irradiation of ultraviolet light, they showed favorable photocatalytic properties. The results suggest that to dope transition metal ions into the framework of CPs would be an ideal option for enhancing the photocatalytic activity of coordination polymers. PMID:24781645

  9. THE ACTIVE CENTAURS

    SciTech Connect

    Jewitt, David

    2009-05-15

    The Centaurs are recent escapees from the Kuiper Belt that are destined either to meet fiery oblivion in the hot inner regions of the solar system or to be ejected to the interstellar medium by gravitational scattering from the giant planets. Dynamically evolved Centaurs, when captured by Jupiter and close enough to the Sun for near-surface water ice to sublimate, are conventionally labeled as 'short-period' (specifically, Jupiter-family) comets. Remarkably, some Centaurs show comet-like activity even when far beyond the orbit of Jupiter, suggesting mass loss driven by a process other than the sublimation of water ice. We observed a sample of 23 Centaurs and found nine to be active, with mass-loss rates measured from several kg s{sup -1} to several tonnes s{sup -1}. Considered as a group, we find that the 'active Centaurs' in our sample have perihelia smaller than the inactive Centaurs (median 5.9 AU versus 8.7 AU), and smaller than the median perihelion distance computed for all known Centaurs (12.4 AU). This suggests that their activity is thermally driven. We consider several possibilities for the origin of the mass loss from the active Centaurs. Most are too cold for activity at the observed levels to originate via the sublimation of crystalline water ice. Solid carbon monoxide and carbon dioxide have the opposite problem: they are so volatile that they should drive activity in Centaurs at much larger distances than observed. We consider the possibility that activity in the Centaurs is triggered by the conversion of amorphous ice into the crystalline form accompanied by the release of trapped gases, including carbon monoxide. By imposing the condition that crystallization should occur when the crystallization time is shorter than the orbital period we find a qualitative match to the perihelion distribution of the active Centaurs and conclude that the data are consistent with the hypothesis that the Centaurs contain amorphous ice.

  10. Physics of solar activity

    NASA Technical Reports Server (NTRS)

    Sturrock, Peter A.

    1993-01-01

    The aim of the research activity was to increase our understanding of solar activity through data analysis, theoretical analysis, and computer modeling. Because the research subjects were diverse and many researchers were supported by this grant, a select few key areas of research are described in detail. Areas of research include: (1) energy storage and force-free magnetic field; (2) energy release and particle acceleration; (3) radiation by nonthermal electrons; (4) coronal loops; (5) flare classification; (6) longitude distributions of flares; (7) periodicities detected in the solar activity; (8) coronal heating and related problems; and (9) plasma processes.

  11. Standardizing Activation Analysis: New Software for Photon Activation Analysis

    SciTech Connect

    Sun, Z. J.; Wells, D.; Green, J.; Segebade, C.

    2011-06-01

    Photon Activation Analysis (PAA) of environmental, archaeological and industrial samples requires extensive data analysis that is susceptible to error. For the purpose of saving time, manpower and minimizing error, a computer program was designed, built and implemented using SQL, Access 2007 and asp.net technology to automate this process. Based on the peak information of the spectrum and assisted by its PAA library, the program automatically identifies elements in the samples and calculates their concentrations and respective uncertainties. The software also could be operated in browser/server mode, which gives the possibility to use it anywhere the internet is accessible. By switching the nuclide library and the related formula behind, the new software can be easily expanded to neutron activation analysis (NAA), charged particle activation analysis (CPAA) or proton-induced X-ray emission (PIXE). Implementation of this would standardize the analysis of nuclear activation data. Results from this software were compared to standard PAA analysis with excellent agreement. With minimum input from the user, the software has proven to be fast, user-friendly and reliable.

  12. Extravehicular activity technology discipline

    NASA Technical Reports Server (NTRS)

    Webbon, Bruce W.

    1990-01-01

    Viewgraphs on extravehicular activity technology discipline for Space Station Freedom are presented. Topics covered include: extravehicular mobility unit; airlock and EMU support equipment; tools, mobility aids, and workstations; and telerobotic work aids interfaces.

  13. Microglial Activation & Chronic Neurodegeneration

    PubMed Central

    Lull, Melinda E.; Block, Michelle L.

    2010-01-01

    Microglia, the resident innate immune cells in the brain, have long been implicated in the pathology of neurodegenerative diseases. Accumulating evidence points to activated microglia as a chronic source of multiple neurotoxic factors, including TNFα, NO, IL1-β, and reactive oxygen species (ROS), driving progressive neuron damage. Microglia can become chronically activated by either a single stimulus (ex. LPS or neuron damage) or multiple stimuli exposures to result in cumulative neuronal loss over time. While the mechanisms driving these phenomena are just beginning to be understood, reactive microgliosis (the microglial response to neuron damage) and ROS have been implicated as key mechanisms of chronic and neurotoxic microglial activation, particularly in the case of Parkinson’s Disease. Here, we review the mechanisms of neurotoxicity associated with chronic microglial activation and discuss the role of neuronal death and microglial ROS driving the chronic and toxic microglial phenotype. PMID:20880500

  14. Activities: Pick's Rule

    ERIC Educational Resources Information Center

    Hirsch, Christian R.

    1974-01-01

    A series of activities are presented on worksheets marked off with lattice points (like a geoboard). Students are led to discover and apply Pick's Theorem for finding the area of a polygon whose vertices are lattice points. (JP)

  15. Finding Activities You Enjoy

    MedlinePlus

    ... choose physical activities that match your interests! Love music? Take dancing lessons. Sign up for an aerobics ... a Safe Environment Feel Down? Get Up—Emotional Benefits of Exercise STAY INFORMED Follow us on Twitter ...

  16. Exercise and activity - children

    MedlinePlus

    ... other organized sports (such as soccer, swimming, and dancing) Younger children cannot stick with the same activity ... in a water sprinkler, or splashing in puddles. Dance to music. Skate, ice-skate, skate-board, or ...

  17. French space activities

    NASA Technical Reports Server (NTRS)

    Blanc, R.

    1982-01-01

    The four main points of research and development of space programs by France are explained. The National Center of Space Studies is discussed, listing the missions of the Center and describing the activities of the staff.

  18. Island Watershed Activity.

    ERIC Educational Resources Information Center

    Benson, Rod

    2003-01-01

    Describes a 90-minute "Island Watershed" activity to help earth science students understand the concept of the water cycle. Introduces a surface waters unit appropriate for students in grades 7-10. Includes watershed project guidelines. (Author/KHR)

  19. Algorithm-development activities

    NASA Technical Reports Server (NTRS)

    Carder, Kendall L.

    1994-01-01

    The task of algorithm-development activities at USF continues. The algorithm for determining chlorophyll alpha concentration, (Chl alpha) and gelbstoff absorption coefficient for SeaWiFS and MODIS-N radiance data is our current priority.

  20. A Big Gulp Activity.

    ERIC Educational Resources Information Center

    Kelly, Bruce

    1997-01-01

    Explains how to implement an activity in which students measure the volume of their oral cavities. Enables students to develop skills in estimation, measurement, connections, statistics, applying concepts and procedures, and communication. (DDR)

  1. Active terahertz metamaterials

    SciTech Connect

    Chen, Hou-tong

    2009-01-01

    We demonstrate planar terahertz metamaterial devices enabling actively controllable transmission amplitude, phase, or frequency at room temperature via carrier depletion or photoexcitation in the semiconductor substrate or in semiconductor materials incorporated into the metamaterial structure.

  2. PRESSURE ACTIVATED SEALANT TECHNOLOGY

    SciTech Connect

    Michael A. Romano

    2004-04-01

    The objective of this project is to develop new, efficient, cost effective methods of internally sealing natural gas pipeline leaks through the application of differential pressure activated sealants. In researching the current state of the art for gas pipeline sealing technologies we concluded that if the project was successful, it appeared that pressure activated sealant technology would provide a cost effective alternative to existing pipeline repair technology. From our analysis of current field data for a 13 year period from 1985 to 1997 we were able to identify 205 leaks that were candidates for pressure activated sealant technology, affirming that pressure activated sealant technology is a viable option to traditional external leak repairs. The data collected included types of defects, areas of defects, pipe sizes and materials, incident and operating pressures, ability of pipeline to be pigged and corrosion states. This data, and subsequent analysis, was utilized as a basis for constructing applicable sealant test modeling.

  3. Intercreativity: Mapping Online Activism

    NASA Astrophysics Data System (ADS)

    Meikle, Graham

    How do activists use the Internet? This article maps a wide range of activist practice and research by applying and developing Tim Berners-Lee's concept of ‘intercreativity' (1999). It identifies four dimensions of Net activism: intercreative texts, tactics, strategies and networks. It develops these through examples of manifestations of Net activism around one cluster of issues: support campaigns for refugees and asylum seekers.

  4. Tinnitus activities treatment.

    PubMed

    Tyler, Richard S; Gogel, Stephanie A; Gehringer, Anne K

    2007-01-01

    Tinnitus Activities Treatment includes counseling of the whole person, and considers individual differences and needs. We consider four areas: thoughts and emotions, hearing and communication, sleep, and concentration. We typically use Partial Masking Sound Therapy, with a noise or music set to the lowest level that provides relief. A picture-based approach facilitates engagement of the patient, and provides thorough and structured counseling. We engage the patient by including homework and activities to demonstrate understanding and facilitate progress. PMID:17956807

  5. Low activation ferritic alloys

    DOEpatents

    Gelles, David S.; Ghoniem, Nasr M.; Powell, Roger W.

    1986-01-01

    Low activation ferritic alloys, specifically bainitic and martensitic stainless steels, are described for use in the production of structural components for nuclear fusion reactors. They are designed specifically to achieve low activation characteristics suitable for efficient waste disposal. The alloys essentially exclude molybdenum, nickel, nitrogen and niobium. Strength is achieved by substituting vanadium, tungsten, and/or tantalum in place of the usual molybdenum content in such alloys.

  6. RMS active damping augmentation

    NASA Technical Reports Server (NTRS)

    Gilbert, Michael G.; Scott, Michael A.; Demeo, Martha E.

    1992-01-01

    The topics are presented in viewgraph form and include: RMS active damping augmentation; potential space station assembly benefits to CSI; LaRC/JSC bridge program; control law design process; draper RMS simulator; MIMO acceleration control laws improve damping; potential load reduction benefit; DRS modified to model distributed accelerations; accelerometer location; Space Shuttle aft cockpit simulator; simulated shuttle video displays; SES test goals and objectives; and SES modifications to support RMS active damping augmentation.

  7. RAVEN Quality Assurance Activities

    SciTech Connect

    Cogliati, Joshua Joseph

    2015-09-01

    This report discusses the quality assurance activities needed to raise the Quality Level of Risk Analysis in a Virtual Environment (RAVEN) from Quality Level 3 to Quality Level 2. This report also describes the general RAVEN quality assurance activities. For improving the quality, reviews of code changes have been instituted, more parts of testing have been automated, and improved packaging has been created. For upgrading the quality level, requirements have been created and the workflow has been improved.

  8. Low activation ferritic alloys

    DOEpatents

    Gelles, D.S.; Ghoniem, N.M.; Powell, R.W.

    1985-02-07

    Low activation ferritic alloys, specifically bainitic and martensitic stainless steels, are described for use in the production of structural components for nuclear fusion reactors. They are designed specifically to achieve low activation characteristics suitable for efficient waste disposal. The alloys essentially exclude molybdenum, nickel, nitrogen and niobium. Strength is achieved by substituting vanadium, tungsten, and/or tantalum in place of the usual molybdenum content in such alloys.

  9. ABB: active bandwidth broker

    NASA Astrophysics Data System (ADS)

    Wong, Kason; Law, Eddie

    2001-07-01

    In this paper, we shall discuss a novel design on the policy-based management for the Internet. This design deploys the concept of active networking. As opposed to the traditional network design, active network empowers network node with the ability to manipulate data and program code in packets, and configure the network properties according to the needs of different applications. The policy-based management can control network routers in order to realize end-to-end Quality of Service (QoS), such as differentiated and integrated services, across the Internet. For the moment, the Internet Engineering Task Force (IETF) has defined the framework of the policy-based management. It employs a simple client/server model that uses Common Open Policy Service (COPS) protocol to facilitate policy management and control. Our design of Active Bandwidth Broker (ABB) belongs to an active application. Our goals are to distribute centralized workload of the policy-based management over multiple active nodes in the active networks, introduce mobility of the bandwidth brokers, and allows load sharing to the policy-based management. This results a network-wide intelligent, highly available, and consistent QoS control that allows performance protection for voice, video and Internet business application while reducing costs for growing networks.

  10. Phytase activity in lichens.

    PubMed

    Higgins, Niall F; Crittenden, Peter D

    2015-10-01

    Phytase activity was investigated in 13 lichen species using a novel assay method. The work tested the hypothesis that phytase is a component of the suite of surface-bound lichen enzymes that hydrolyse simple organic forms of phosphorus (P) and nitrogen (N) deposited onto the thallus surface. Hydrolysis of inositol hexaphosphate (InsP6 , the substrate for phytase) and appearance of lower-order inositol phosphates (InsP5 -InsP1 ), the hydrolysis products, were measured by ion chromatography. Phytase activity in Evernia prunastri was compared among locations with contrasting rates of N deposition. Phytase activity was readily measurable in epiphytic lichens (e.g. 11.3 μmol InsP6 hydrolysed g(-1)  h(-1) in Bryoria fuscescens) but low in two terricolous species tested (Cladonia portentosa and Peltigera membranacea). Phytase and phosphomonoesterase activities were positively correlated amongst species. In E. prunastri both enzyme activities were promoted by N enrichment and phytase activity was readily released into thallus washings. InsP6 was not detected in tree canopy throughfall but was present in pollen leachate. Capacity to hydrolyse InsP6 appears widespread amongst lichens potentially promoting P capture from atmospheric deposits and plant leachates, and P cycling in forest canopies. The enzyme assay used here might find wider application in studies on plant root-fungal-soil systems. PMID:25963718

  11. Anticancer Activity of Amauroderma rude

    PubMed Central

    Yang, Xiangling; Li, Haoran; Li, Xiang-Min; Pan, Hong-Hui; Cai, Mian-Hua; Zhong, Hua-Mei; Yang, Burton B.

    2013-01-01

    More and more medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients. Here we report screening thirteen mushrooms for anti-cancer cell activities in eleven different cell lines. Of the herbal products tested, we found that the extract of Amauroderma rude exerted the highest activity in killing most of these cancer cell lines. Amauroderma rude is a fungus belonging to the Ganodermataceae family. The Amauroderma genus contains approximately 30 species widespread throughout the tropical areas. Since the biological function of Amauroderma rude is unknown, we examined its anti-cancer effect on breast carcinoma cell lines. We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucidum. We then examined the effect of Amauroderma rude on breast cancer cells and found that at low concentrations, Amauroderma rude could inhibit cancer cell survival and induce apoptosis. Treated cancer cells also formed fewer and smaller colonies than the untreated cells. When nude mice bearing tumors were injected with Amauroderma rude extract, the tumors grew at a slower rate than the control. Examination of these tumors revealed extensive cell death, decreased proliferation rate as stained by Ki67, and increased apoptosis as stained by TUNEL. Suppression of c-myc expression appeared to be associated with these effects. Taken together, Amauroderma rude represented a powerful medicinal mushroom with anti-cancer activities. PMID:23840494

  12. Youth Physical Activity Resources Use and Activity Measured by Accelerometry

    PubMed Central

    Maslow, Andréa L.; Colabianchi, Natalie

    2014-01-01

    Objectives To examine whether utilization of physical activity resources (eg, parks) was associated with daily physical activity measured by accelerometry. Methods 111 adolescents completed a travel diary with concurrent accelerometry. The main exposure was self-reported utilization of a physical activity resource (none/1+ resources). The main outcomes were total minutes spent in daily 1) moderate-vigorous physical activity and 2) vigorous physical activity. Results Utilizing a physical activity resource was significantly associated with total minutes in moderate-vigorous physical activity. African-Americans and males had significantly greater moderate-vigorous physical activity. Conclusions Results from this study support the development and use of physical activity resources. PMID:21204684

  13. Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth.

    PubMed

    Cheng, Jonathan D; Valianou, Matthildi; Canutescu, Adrian A; Jaffe, Eileen K; Lee, Hyung-Ok; Wang, Hao; Lai, Jack H; Bachovchin, William W; Weiner, Louis M

    2005-03-01

    Tumor-associated fibroblasts are functionally and phenotypically distinct from normal fibroblasts that are not in the tumor microenvironment. Fibroblast activation protein is a 95 kDa cell surface glycoprotein expressed by tumor stromal fibroblasts, and has been shown to have dipeptidyl peptidase and collagenase activity. Site-directed mutagenesis at the catalytic site of fibroblast activation protein, Ser624 --> Ala624, resulted in an approximately 100,000-fold loss of fibroblast activation protein dipeptidyl peptidase (DPP) activity. HEK293 cells transfected with wild-type fibroblast activation protein, enzymatic mutant (S624A) fibroblast activation protein, or vector alone, were inoculated subcutaneously into immunodeficient mouse to assess the contribution of fibroblast activation protein enzymatic activity to tumor growth. Overexpression of wild-type fibroblast activation protein showed growth potentiation and enhanced tumorigenicity compared with both fibroblast activation protein S624A and vector-transfected HEK293 xenografts. HEK293 cells transfected with fibroblast activation protein S624A showed tumor growth rates and tumorigenicity potential similar only to vector-transfected HEK293. In vivo assessment of fibroblast activation protein DPP activity of these tumors showed enhanced enzymatic activity of wild-type fibroblast activation protein, with only baseline levels of fibroblast activation protein DPP activity in either fibroblast activation protein S624A or vector-only xenografts. These results indicate that the enzymatic activity of fibroblast activation protein is necessary for fibroblast activation protein-driven tumor growth in the HEK293 xenograft model system. This establishes the proof-of-principle that the enzymatic activity of fibroblast activation protein plays an important role in the promotion of tumor growth, and provides an attractive target for therapeutics designed to alter fibroblast activation protein-induced tumor growth by targeting

  14. Photon-activation therapy

    SciTech Connect

    Fairchild, R.G.; Bond, V.P.

    1982-01-01

    Photon Activation Therapy (PAT) is a technique in which radiation dose to tumor is enhanced via introduction of stable /sup 127/I in the form of iodinated deoxyuridine (IdUrd). Stimulation of cytotoxic effects from IdUrd is accomplished by activation with external (or implanted) radiation sources. Thus, accumulations of this nucleoside in actively competing cellpools do not preclude therapy in so far as such tissues can be excluded from the radiation field. Calculations show that 5% replacement of thymidine (Tyd) in tumor DNA should enhance the biological effectiveness of a given photon radiotherapy dose by a factor of approx. 3. Proportionally higher gains would result from higher replacements of Tyd and IdUrd. In addition, biological response is enhanced by chemical sensitization with IdUrd. The data indicate that damage from photon activation as well as chemical sensitization does not repair. Thus, at low dose rates, a further increase in therapeutic gain should accrue as normal tissues are allowed to repair and regenerate. A samarium-145 source has been developed for PAT, with activating x-ray energies of from 38 to 45 keV. Favorable clinical results can be expected through the use of IdUrd and protracted irradiations with low energy x-rays. In particular, PAT may provide unique advantages at selected sites such as brain, or head and neck tumors. (ERB)

  15. [Inflammasome: activation mechanisms].

    PubMed

    Suárez, Raibel; Buelvas, Neudo

    2015-03-01

    Inflammation is a rapid biologic response of the immune system in vascular tissues, directed to eliminate stimuli capable of causing damage and begin the process of repair. The macromolecular complexes known as "inflammasomes" are formed by a receptor, either NOD (NLR) or ALR, the receptor absent in melanoma 2 (AIM2). In addition, the inflammasome is formed by the speck-like protein associated to apoptosis (ASC) and procaspase-1, that may be activated by variations in the ionic and intracellular and extracellular ATP concentrations; and the loss of stabilization of the fagolisosomme by internalization of insoluble crystals and redox mechanisms. As a result, there is activation of the molecular platform and the processing of inflammatory prointerleukins to their active forms. There are two modalities of activation of the inflammasome: canonical and non-canonical, both capable of generating effector responses. Recent data associate NLRP 3, IL-1β and IL-18 in the pathogenesis of a variety of diseases, including atherosclerosis, type II diabetes, hyperhomocysteinemia, gout, malaria and hypertension. The inflammasome cascade is emerging as a new chemotherapeutic target in these diseases. In this review we shall discuss the mechanisms of activation and regulation of the inflammasome that stimulate, modulate and resolve inflammation. PMID:25920188

  16. Mechanochemically Active Soft Robots.

    PubMed

    Gossweiler, Gregory R; Brown, Cameron L; Hewage, Gihan B; Sapiro-Gheiler, Eitan; Trautman, William J; Welshofer, Garrett W; Craig, Stephen L

    2015-10-14

    The functions of soft robotics are intimately tied to their form-channels and voids defined by an elastomeric superstructure that reversibly stores and releases mechanical energy to change shape, grip objects, and achieve complex motions. Here, we demonstrate that covalent polymer mechanochemistry provides a viable mechanism to convert the same mechanical potential energy used for actuation in soft robots into a mechanochromic, covalent chemical response. A bis-alkene functionalized spiropyran (SP) mechanophore is cured into a molded poly(dimethylsiloxane) (PDMS) soft robot walker and gripper. The stresses and strains necessary for SP activation are compatible with soft robot function. The color change associated with actuation suggests opportunities for not only new color changing or camouflaging strategies, but also the possibility for simultaneous activation of latent chemistry (e.g., release of small molecules, change in mechanical properties, activation of catalysts, etc.) in soft robots. In addition, mechanochromic stress mapping in a functional robotic device might provide a useful design and optimization tool, revealing spatial and temporal force evolution within the robot in a way that might be coupled to autonomous feedback loops that allow the robot to regulate its own activity. The demonstration motivates the simultaneous development of new combinations of mechanophores, materials, and soft, active devices for enhanced functionality. PMID:26390078

  17. Active imaging at DARPA

    NASA Astrophysics Data System (ADS)

    Ricklin, J. C.; Tomlinson, P. G.

    2005-08-01

    Active systems, because they provide their own illumination, are capable of operating 24 hours a day and are not dependent upon the angle of the sun. Unlike passive systems, they can provide three-dimensional imaging. DARPA is currently developing systems, technologies, and signal processing to pioneer new or improve existing capabilities that employ active imaging capabilities. These involve both radar and ladar, ranging from a few MHz for foliage penetration to near-visible IR to achieve ultra-high resolution at long range. These capabilities would improve Battlefield Awareness (BA) and provide persistent Intelligence, Surveillance, and Reconnaissance (ISR) to perform target detection, recognition, and identification. This paper discusses two different approaches to active optical imaging. One is a coherent approach that uses synthetic aperture techniques with infrared laser radar, and another approach uses only the intensity of the speckle pattern in the aperture plane. Both are capable of producing ultra-high resolution at long range.

  18. Prenucleosomes and Active Chromatin

    PubMed Central

    Khuong, Mai T.; Fei, Jia; Ishii, Haruhiko; Kadonaga, James T.

    2016-01-01

    Chromatin consists of nucleosomes as well as nonnucleosomal histone-containing particles. Here we describe the prenucleosome, which is a stable conformational isomer of the nucleosome that associates with ~80 bp DNA. Prenucleosomes are formed rapidly upon the deposition of histones onto DNA and can be converted into canonical nucleosomes by an ATP-driven chromatin assembly factor such as ACF. Different lines of evidence reveal that there are prenucleosome-sized DNA-containing particles with histones in the upstream region of active promoters. Moreover, p300 acetylates histone H3K56 in prenucleosomes but not in nucleosomes, and H3K56 acetylation is found at active promoters and enhancers. These findings therefore suggest that there may be prenucleosomes or prenucleosome-like particles in the upstream region of active promoters. More generally, we postulate that prenucleosomes or prenucleosome-like particles are present at dynamic chromatin, whereas canonical nucleosomes are at static chromatin. PMID:26767995

  19. Flare Activity on Stars

    NASA Astrophysics Data System (ADS)

    Oskanian, V. S.

    A review of the existing flare data analyses indicates that most probably the flare phenomenon should be considered as one of the manifestation forms of solar-type chromospheric activity on stars and therefore has to be investigated in common with other phenomena specifying this activity. In order to estimate the reliability of such an approach different types of observational data are discussed. It could be shown that most of the phenomena specifying the solar chromospheric activity (BY Dra syndrome, indicating the spottedness of the stellar surface, long-term cyclic variations of emission line intensities, variable local magnetic fields, flares, coronal phenomena, etc.) are observable on a constantly growing number of stars of almost all spectral types and luminosity classes. This fact indicates that the proposed approach could be the right way to solve the problem of the flare phenomenon.

  20. Activity Cycles in Stars

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.

    2009-01-01

    Starspots and stellar activity can be detected in other stars using high precision photometric and spectrometric measurements. These observations have provided some surprises (starspots at the poles - sunspots are rarely seen poleward of 40 degrees) but more importantly they reveal behaviors that constrain our models of solar-stellar magnetic dynamos. The observations reveal variations in cycle characteristics that depend upon the stellar structure, convection zone dynamics, and rotation rate. In general, the more rapidly rotating stars are more active. However, for stars like the Sun, some are found to be inactive while nearly identical stars are found to be very active indicating that periods like the Sun's Maunder Minimum (an inactive period from 1645 to 1715) are characteristic of Sun-like stars.

  1. Clinical efficacy, radiographic and safety findings through 5 years of subcutaneous golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of a randomised, placebo-controlled trial (the GO-REVEAL study)

    PubMed Central

    Kavanaugh, Arthur; McInnes, Iain B; Mease, Philip; Krueger, Gerald G; Gladman, Dafna; van der Heijde, Désirée; Zhou, Yiying; Lu, Jiandong; Leu, Jocelyn H; Goldstein, Neil; Beutler, Anna

    2014-01-01

    Objectives Assess golimumab's long-term efficacy/safety in psoriatic arthritis (PsA). Methods Adults with active PsA (≥3 swollen and tender joints, active psoriasis) were randomly assigned to subcutaneous placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks (q4wks) through wk20. All patients received golimumab 50 mg or 100 mg q4wks from wk24 forward. Methotrexate was allowed and taken by approximately half the patients. Findings through 5 years are reported herein. Efficacy assessments included ≥20% improvement in American College of Rheumatology (ACR20) response, C-reactive-protein-based, 28-joint-count Disease Activity Score (DAS28-CRP) response, ≥75% improvement in Psoriasis Area and Severity Index (PASI75) scores, and PsA-modified Sharp/van der Heijde scores (SHSs). Results 126/405 (31%) randomised patients discontinued treatment through wk252. Golimumab was effective in maintaining clinical improvement through year-5 (ACR20: 62.8–69.9%, DAS28-CRP: 75.2-84.9% for randomised patients; PASI75: 60.8–72.2% among randomised patients with ≥3% body surface area involvement) and inhibiting radiographic progression (mean changes in PsA-modified SHS: 0.1–0.3) among patients with radiographic data. While concomitant methotrexate did not affect ACR20/PASI75, it appeared to reduce radiographic progression. No new safety signals were identified. Antibodies-to-golimumab occurred in 1.8%/10.0% of patients with/without methotrexate). Conclusions Long-term golimumab safety/efficacy in PsA was demonstrated through 5 years. Trial registration number NCT00265096. PMID:24748630

  2. 77 FR 36010 - Agency Information Collection Activities; Agency Information Collection Activities; Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities; Agency Information Collection Activities; Proposed Collection; Extension of a Currently Approved Collection; Comment Requested Deaths in Custody--Series of Collections From...

  3. Space construction activities

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Center for Space Construction at the University of Colorado at Boulder was established in 1988 as a University Space Engineering Research Center. The mission of the Center is to conduct interdisciplinary engineering research which is critical to the construction of future space structures and systems and to educate students who will have the vision and technical skills to successfully lead future space construction activities. The research activities are currently organized around two central projects: Orbital Construction and Lunar Construction. Summaries of the research projects are included.

  4. MCO Monitoring activity description

    SciTech Connect

    SEXTON, R.A.

    1998-11-09

    Spent Nuclear Fuel remaining from Hanford's N-Reactor operations in the 1970s has been stored under water in the K-Reactor Basins. This fuel will be repackaged, dried and stored in a new facility in the 200E Area. The safety basis for this process of retrieval, drying, and interim storage of the spent fuel has been established. The monitoring of MCOS in dry storage is a currently identified issue in the SNF Project. This plan outlines the key elements of the proposed monitoring activity. Other fuel stored in the K-Reactor Basins, including SPR fuel, will have other monitoring considerations and is not addressed by this activity description.

  5. Inflammasomes and Their Activation

    PubMed Central

    Khare, Sonal; Luc, Nancy; Dorfleutner, Andrea; Stehlik, Christian

    2011-01-01

    The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition receptors that activate inflammasomes in macrophages. Inflammasomes are protein platforms essential for the activation of inflammatory caspases and subsequent maturation of their pro-inflammatory cytokine substrates and induction of pyroptosis. This paper summarizes recent developments regarding the function of Nod-like receptors in immunity and disease. PMID:21083527

  6. Active cleaning technique device

    NASA Technical Reports Server (NTRS)

    Shannon, R. L.; Gillette, R. B.

    1973-01-01

    The objective of this program was to develop a laboratory demonstration model of an active cleaning technique (ACT) device. The principle of this device is based primarily on the technique for removing contaminants from optical surfaces. This active cleaning technique involves exposing contaminated surfaces to a plasma containing atomic oxygen or combinations of other reactive gases. The ACT device laboratory demonstration model incorporates, in addition to plasma cleaning, the means to operate the device as an ion source for sputtering experiments. The overall ACT device includes a plasma generation tube, an ion accelerator, a gas supply system, a RF power supply and a high voltage dc power supply.

  7. Activated carbon material

    DOEpatents

    Evans, A. Gary

    1978-01-01

    Activated carbon particles for use as iodine trapping material are impregnated with a mixture of selected iodine and potassium compounds to improve the iodine retention properties of the carbon. The I/K ratio is maintained at less than about 1 and the pH is maintained at above about 8.0. The iodine retention of activated carbon previously treated with or coimpregnated with triethylenediamine can also be improved by this technique. Suitable flame retardants can be added to raise the ignition temperature of the carbon to acceptable standards.

  8. Cryogenic activities at ESTEC

    NASA Astrophysics Data System (ADS)

    Jewell, C. I.

    1989-05-01

    Although the main present cryogenic activity in ESTEC revolves around the preparation of ISO for launch in 1993, many other activities such as Meteosat second generation, FIRST, GRASP, QUASAT, and X-ray detection using bolometers all require some form of cooling to 80 K or less. ESTEC, in an effort to overcome the major constraint of lifetime when using the solution of cryogens is currently involved in the study and development of two mechanical coolers for work in the temperature ranges of 80 and 4 K are based on a Stirling cycle. This paper gives an overview of ESTEC cryogenic interests with an emphasis on the above mechanical coolers.

  9. Solar cell activation system

    SciTech Connect

    Apelian, L.

    1983-07-05

    A system for activating solar cells involves the use of phosphorescent paint, the light from which is amplified by a thin magnifying lens and used to activate solar cells. In a typical system, a member painted with phosphorescent paint is mounted adjacent a thin magnifying lens which focuses the light on a predetermined array of sensitive cells such as selenium, cadmium or silicon, mounted on a plastic board. A one-sided mirror is mounted adjacent the cells to reflect the light back onto said cells for purposes of further intensification. The cells may be coupled to rechargeable batteries or used to directly power a small radio or watch.

  10. Active seismic experiment

    NASA Technical Reports Server (NTRS)

    Kovach, R. L.; Watkins, J. S.; Talwani, P.

    1972-01-01

    The Apollo 16 active seismic experiment (ASE) was designed to generate and monitor seismic waves for the study of the lunar near-surface structure. Several seismic energy sources are used: an astronaut-activated thumper device, a mortar package that contains rocket-launched grenades, and the impulse produced by the lunar module ascent. Analysis of some seismic signals recorded by the ASE has provided data concerning the near-surface structure at the Descartes landing site. Two compressional seismic velocities have so far been recognized in the seismic data. The deployment of the ASE is described, and the significant results obtained are discussed.

  11. Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma

    PubMed Central

    Park, Tae Woo; Lee, Kyungmin; Lee, Dong Gwang; Cho, Young-Lai; Lee, Tae Sup; Na, Hee-Jun; Park, Young-Jun; Lee, Hee Gu; Jeong, Mun Sik; Bae, Kwang-Hee; Lee, Sang Chul; Lee, Hyo Jin; Kwon, Young-Guen; Hong, Hyo Jeong; Kim, Jang-Seong; Min, Jeong-Ki

    2015-01-01

    Endostatin is an endogenous angiogenesis inhibitor that exhibits potential anti-tumor efficacy in various preclinical animal models. However, its relatively short in vivo half-life and the long-term, frequent administration of high doses limit its widespread clinical use. In this study, we evaluated whether a fusion protein of murine endostatin (mEndo) to a humanized antibody against tumor-associated glycoprotein 72 (TAG-72), which is highly expressed in several human tumor tissues including colon cancer, can extend the serum half-life and improve the anti-tumor efficacy of endostatin by targeted delivery to the tumor mass. The fusion protein (3E8-mEndo) and mEndo showed improved anti-angiogenic activity in vitro and in vivo, predominantly by interfering with pro-angiogenic signaling triggered by vascular endothelial growth factor (VEGF). Moreover, in mice treated with 3E8-mEndo, we observed a markedly prolonged serum half-life and significantly inhibited tumor growth. The improved anti-tumor activity of 3E8-mEndo can be partially explained by increased local concentration in the tumor mass due to targeted delivery of 3E8-mEndo to implanted colon tumors. Collectively, our data clearly indicate that tumor-targeting antibody fusions to endostatin are a powerful strategy that improves the poor pharmacokinetic profile and anti-tumor efficacy of endostatin. PMID:25762629

  12. Physical Activities for Preschool.

    ERIC Educational Resources Information Center

    Adkins, Dorothy C.; And Others

    The underlying premise of the University of Hawaii Physical Activities for Preschool curriculum is that important contributions to a positive self-concept are made by motor independence and a realistic body image. Program objectives include: (1) the development of strength, endurance, and flexibility in skills that involve the muscles,…

  13. The Puzzle Design Activity.

    ERIC Educational Resources Information Center

    Meyer, Marc E.

    1983-01-01

    A sampling of puzzles and games produced by students at North Rockland High School (New York) are presented as an example of a way student-designed activities can be used to cover a specific unit within the health education curriculum. Produced by 9th and 10th graders, the unit on alcohol consists of puzzles and word games using related vocabulary…

  14. [Problem Solving Activities.

    ERIC Educational Resources Information Center

    Wisconsin Univ. - Stout, Menomonie. Center for Vocational, Technical and Adult Education.

    The teacher directed problem solving activities package contains 17 units: Future Community Design, Let's Build an Elevator, Let's Construct a Catapult, Let's Design a Recreational Game, Let's Make a Hand Fishing Reel, Let's Make a Wall Hanging, Let's Make a Yo-Yo, Marooned in the Past, Metrication, Mousetrap Vehicles, The Multi System…

  15. Production Systems. Laboratory Activities.

    ERIC Educational Resources Information Center

    Gallaway, Ann, Ed.

    This production systems guide provides teachers with learning activities for secondary students. Introductory materials include an instructional planning outline and worksheet, an outline of essential elements, domains and objectives, a course description, and a content outline. The guide contains 30 modules on the following topics: production…

  16. Elastolytic activity among staphylococci.

    PubMed Central

    Janda, J M

    1986-01-01

    A total of 161 isolates of the genus Staphylococcus were evaluated for the ability to produce elastase. Elastase activity was detected only in S. epidermidis strains (sensu stricto), being absent in S. aureus isolates and other coagulase-negative staphylococci tested. The elastase elaborated by S. epidermidis isolates appeared to be an inducible enzyme whose synthesis was medium dependent. PMID:3640774

  17. Activities: Preparing for Pythagoras.

    ERIC Educational Resources Information Center

    Laing, Robert A.

    1989-01-01

    Three worksheets are provided to help secondary students explore relationships among the areas of a variety of similar figures constructed on the sides of right triangles. The activity is extended to include the relationship among the lengths of the sides of the right triangle. Included are several student worksheets. (DC)

  18. Active-bridge oscillator

    DOEpatents

    Wessendorf, Kurt O.

    2001-01-01

    An active bridge oscillator is formed from a differential amplifier where positive feedback is a function of the impedance of one of the gain elements and a relatively low value common emitter resistance. This use of the nonlinear transistor parameter h stabilizes the output and eliminates the need for ALC circuits common to other bridge oscillators.

  19. Regional Activities Division. Papers.

    ERIC Educational Resources Information Center

    International Federation of Library Associations, The Hague (Netherlands).

    Papers on library network activities in Canada, the Third World, Japan, Malaysia, Brazil, and Sweden which were presented at the 1982 International Federation of Library Associations (IFLA) conference include: (1) "Canada: A Voluntary and Flexible Network," a review by Guy Sylvestre of the political, social, and economic structures affecting…

  20. Facilitating Active Learner Participation.

    ERIC Educational Resources Information Center

    Rosenberg, Steven; And Others

    1992-01-01

    Project Participate has developed and implemented a model for making decisions about interventions that enhance the ability of a preschool child with severe motor disabilities to actively participate in educational programs. The effectiveness of the process in increasing child participation in play, communication, social interaction, and mobility…