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Sample records for activities extension activities

  1. 75 FR 48921 - Administrative Guidance for Multistate Extension Activities and Integrated Research and Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ...: ``Cooperative State Research, Education, and Extension Service's Implementation of the Agricultural Research... amount of agricultural extension formula funds be expended on multistate extension activities. Section... agricultural research and extension formula funds be expended on integrated research and extension...

  2. Student Activities . . . an Extension of the Curriculum.

    ERIC Educational Resources Information Center

    Grady, Joan B.

    1981-01-01

    Extracurricular activities in secondary schools are an important part of student preparation for adult life. This document presents guidelines on the components, administration, and evaluation of student activities. It suggests that a comprehensive activity program should include student government, publications, cultural activities, service…

  3. Exploring Extension Involvement in Farm to School Program Activities

    ERIC Educational Resources Information Center

    Benson, Matthew C.

    2014-01-01

    The study reported here examined Extension professionals' involvement in farm-to-school program activities. Results of an online survey distributed to eight state Extension systems indicate that on average, Extension professionals are involved with one farm to school program activity, with most supporting school or community garden programs.…

  4. The relationships between active extensibility, and passive and active stiffness of the knee flexors.

    PubMed

    Blackburn, J Troy; Padua, Darin A; Riemann, Bryan L; Guskiewicz, Kevin M

    2004-12-01

    Insufficient active knee flexor stiffness may predispose the anterior cruciate ligament to injury. Insufficient passive stiffness may result in insufficient active stiffness. Similarly, higher levels of musculotendinous extensibility may inhibit active and passive muscle stiffness, potentially contributing to an increased risk of injury. The literature is both limited and inconsistent concerning relationships between extensibility, passive stiffness, and active stiffness. Extensibility was measured as the maximal active knee extension angle from a supine position with the hip flexed to 90 degrees . Passive stiffness was calculated as the slope of the moment-angle curve resulting from passive knee extension. Active stiffness was assessed via acceleration associated with damped oscillatory motion about the knee. Stepwise multiple regression indicated that passive stiffness accounted for 25% of active muscle stiffness variance. The linear combination of extensibility and passive stiffness explained only 2% more variance compared to passive stiffness alone. Musculotendinous extensibility was moderately related to passive muscle stiffness, and weakly related to active muscle stiffness. The moderate relationship observed between active and passive stiffness emphasizes the dependence of active muscle stiffness on cross-bridge formation, and the relatively smaller contribution from parallel elastic tissues. Additionally, heightened extensibility does not appear to be a predisposing factor for reduced muscle stiffness. PMID:15491843

  5. Enhanced muscle activity during lumbar extension exercise with pelvic stabilization.

    PubMed

    Lee, Ho-Seong

    2015-12-01

    The purpose of this study was to investigate whether pelvic stabilization affects multifidus (MF) and iliocostalis lumborum (IL) muscle activities during dynamic extension exercise. Nine males (age, 25.1±6.3 yr; height, 176.6±2.4 cm; body mass, 74.9±6.7 kg) performed an isometric lumbar extension strength test and dynamic exercise in an upright seated position with or without pelvic stabilization. The electromyography and muscle strength of the MF and IL muscles were measured when the subjects performed the isometric lumbar extension strength test at the trunk angle 110°, 146°, and 182°. In addition, the trunk extensor muscle activities were measured using 50% muscle strength of maximum isometric strength during a dynamic trunk extension exercise. The MF and IL muscle activities were significantly higher at 110°, 146°, and 182° with pelvic stabilization than that without pelvic stabilization during the isometric lumbar extension strength test (P<0.05) and the dynamic exercise (P<0.05). These results suggest that the lumbar extension exercise with pelvic stabilization may be more effective for MF and IL muscle activity compared to that without pelvic stabilization.

  6. Enhanced muscle activity during lumbar extension exercise with pelvic stabilization

    PubMed Central

    Lee, Ho-Seong

    2015-01-01

    The purpose of this study was to investigate whether pelvic stabilization affects multifidus (MF) and iliocostalis lumborum (IL) muscle activities during dynamic extension exercise. Nine males (age, 25.1±6.3 yr; height, 176.6±2.4 cm; body mass, 74.9±6.7 kg) performed an isometric lumbar extension strength test and dynamic exercise in an upright seated position with or without pelvic stabilization. The electromyography and muscle strength of the MF and IL muscles were measured when the subjects performed the isometric lumbar extension strength test at the trunk angle 110°, 146°, and 182°. In addition, the trunk extensor muscle activities were measured using 50% muscle strength of maximum isometric strength during a dynamic trunk extension exercise. The MF and IL muscle activities were significantly higher at 110°, 146°, and 182° with pelvic stabilization than that without pelvic stabilization during the isometric lumbar extension strength test (P<0.05) and the dynamic exercise (P<0.05). These results suggest that the lumbar extension exercise with pelvic stabilization may be more effective for MF and IL muscle activity compared to that without pelvic stabilization. PMID:26730390

  7. 75 FR 54363 - BOEMRE Information Collection Activity: 1010-0142, Decommissioning Activities, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... 22, 2010, we published a Federal Register notice (75 FR 13568) announcing that we would submit this...: 1010-0142, Decommissioning Activities, Extension of a Collection, Submitted for Office of Management... Enforcement (BOEMRE), Interior. ACTION: Notice of extension of an information collection (1010-0142)....

  8. 77 FR 37716 - Comment Request for Information Collection for Claims and Payment Activities, Extension Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    .... III. Current Actions Type of Review: Extension without changes. Title: Claims and Payment Activities... Activities, Extension Without Revisions. AGENCY: Employment and Training Administration (ETA), Labor....

  9. Using Non-Extension Volunteering as an Experiential Learning Activity for Extension Professionals

    ERIC Educational Resources Information Center

    Andrews, Kevin B.; Lockett, Landry L.

    2013-01-01

    Extension professionals can gain much-needed competencies in volunteer administration through experiential learning by participating in volunteer activities. Experiential learning is a means of behavior change that allows the individual learner to reflect on, abstract, and apply their experiences to new situations. This article expands on…

  10. 75 FR 13568 - MMS Information Collection Activity: 1010-0142, Decommissioning Activities, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... Minerals Management Service MMS Information Collection Activity: 1010-0142, Decommissioning Activities...: Notice of extension of an information collection (1010-0142). SUMMARY: To comply with the Paperwork... Elden Street, MS-4024; Herndon, Virginia 20170-4817. Please reference ICR 1010-0142 in your comment...

  11. A Fungal Endoglucanase with Plant Cell Wall Extension Activity1

    PubMed Central

    Yuan, Sheng; Wu, Yajun; Cosgrove, Daniel J.

    2001-01-01

    We have identified a wall hydrolytic enzyme from Trichoderma reesei with potent ability to induce extension of heat-inactivated type I cell walls. It is a small (23-kD) endo-1,4-β-glucanase (Cel12A) belonging to glycoside hydrolase family 12. Extension of heat-inactivated walls from cucumber (Cucumis sativus cv Burpee Pickler) hypocotyls was induced by Cel12A after a distinct lag time and was accompanied by a large increase in wall plasticity and elasticity. Cel12A also increased the rate of stress relaxation of isolated walls at very short times (<200 ms; equivalent to reducing t0, a parameter that estimates the minimum relaxation time). Similar changes in wall plasticity and elasticity were observed in wheat (Triticum aestivum cv Pennmore Winter) coleoptile (type II) walls, which showed only a negligible extension in response to Cel12A treatment. Thus, Cel12A modifies both type I and II walls, but substantial extension is found only in type I walls. Cel12A has strong endo-glucanase activity against xyloglucan and (1→3,1→4)-β-glucan, but did not exhibit endo-xylanase, endo-mannase, or endo-galactanase activities. In terms of kinetics of action and effects on wall rheology, wall loosening by Cel12A differs qualitatively from the action by expansins, which induce wall extension by a non-hydrolytic polymer creep mechanism. The action by Cel12A mimics some of the changes in wall rheology found after auxin-induced growth. The strategy used here to identify Cel12A could be used to identify analogous plant enzymes that cause auxin-induced changes in cell wall rheology. PMID:11553760

  12. Activities.

    ERIC Educational Resources Information Center

    Mathematics Teacher, 1982

    1982-01-01

    The material presented is designed to help students explore geometric patterns involving Fibonnaci numbers and the golden ratio, and to aid in review of basic geometry skills. Worksheet masters intended for duplication are provided. Suggestions are made of possible classroom extensions to the initial activities. (MP)

  13. Three determinants in ezrin are responsible for cell extension activity.

    PubMed Central

    Martin, M; Roy, C; Montcourrier, P; Sahuquet, A; Mangeat, P

    1997-01-01

    The ERM proteins--ezrin, radixin, and moesin--are key players in membrane-cytoskeleton interactions. In insect cells infected with recombinant baculoviruses, amino acids 1-115 of ezrin were shown to inhibit an actin- and tubulin-dependent cell-extension activity located in ezrin C-terminal domain (ezrin310-586), whereas full-length ezrin1-586 did not induce any morphological change. To refine the mapping of functional domains of ezrin, 30 additional constructs were overexpressed in Sf9 cells, and the resulting effect of each was qualitatively and semiquantitatively compared. The removal of amino acids 13-30 was sufficient to release a cell-extension phenotype. This effect was abrogated if the 21 distal-most C-terminal amino acids were subsequently deleted (ezrin31-565), confirming the existence of a head-to-tail regulation in the whole molecule. Surprisingly, the deletion in full-length ezrin of the same 21 amino acids provided strong cell-extension competence to ezrin1-565, and this property was recovered in N-terminal constructs as short as ezrin1-310. Within ezrin1-310, amino acid sequences 13-30 and 281-310 were important determinants and acted in cooperation to induce cytoskeleton mobilization. In addition, these same residues are part of a new actin-binding site characterized in vitro in ezrin N-terminal domain. Images PMID:9285824

  14. Passive resting state and history of antagonist muscle activity shape active extensions in an insect limb

    PubMed Central

    Ache, Jan M.

    2012-01-01

    Limb movements can be driven by muscle contractions, external forces, or intrinsic passive forces. For lightweight limbs like those of insects or small vertebrates, passive forces can be large enough to overcome the effects of gravity and may even generate limb movements in the absence of active muscle contractions. Understanding the sources and actions of such forces is therefore important in understanding motor control. We describe passive properties of the femur-tibia joint of the locust hind leg. The resting angle is determined primarily by passive properties of the relatively large extensor tibiae muscle and is influenced by the history of activation of the fast extensor tibiae motor neuron. The resting angle is therefore better described as a history-dependent resting state. We selectively stimulated different flexor tibiae motor neurons to generate a range of isometric contractions of the flexor tibiae muscle and then stimulated the fast extensor tibiae motor neuron to elicit active tibial extensions. Residual forces in the flexor muscle have only a small effect on subsequent active extensions, but the effect is larger for distal than for proximal flexor motor neurons and varies with the strength of flexor activation. We conclude that passive properties of a lightweight limb make substantial and complex contributions to the resting state of the limb that must be taken into account in the patterning of neuronal control signals driving its active movements. Low variability in the effects of the passive forces may permit the nervous system to accurately predict their contributions to behavior. PMID:22357791

  15. An Extensible, User- Modifiable Framework for Planning Activities

    NASA Technical Reports Server (NTRS)

    Joshing, Joseph C.; Abramyan, Lucy; Mickelson, Megan C.; Wallick, Michael N.; Kurien, James A.; Crockett, Thomasa M.; Powell, Mark W.; Pyrzak, Guy; Aghevli, Arash

    2013-01-01

    This software provides a development framework that allows planning activities for the Mars Science Laboratory rover to be altered at any time, based on changes of the Activity Dictionary. The Activity Dictionary contains the definition of all activities that can be carried out by a particular asset (robotic or human). These definitions (and combinations of these definitions) are used by mission planners to give a daily plan of what a mission should do. During the development and course of the mission, the Activity Dictionary and actions that are going to be carried out will often be changed. Previously, such changes would require a change to the software and redeployment. Now, the Activity Dictionary authors are able to customize activity definitions, parameters, and resource usage without requiring redeployment. This software provides developers and end users the ability to modify the behavior of automatically generated activities using a script. This allows changes to the software behavior without incurring the burden of redeployment. This software is currently being used for the Mars Science Laboratory, and is in the process of being integrated into the LADEE (Lunar Atmosphere and Dust Environment Explorer) mission, as well as the International Space Station.

  16. 32 CFR 767.8 - Requests for amendments or extensions of active permits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Requests for amendments or extensions of active permits. 767.8 Section 767.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... extensions of active permits. (a) Requests for amendments to active permits (e.g., a change in study...

  17. 32 CFR 767.8 - Requests for amendments or extensions of active permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Requests for amendments or extensions of active permits. 767.8 Section 767.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... extensions of active permits. (a) Requests for amendments to active permits (e.g., a change in study...

  18. 32 CFR 767.8 - Requests for amendments or extensions of active permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Requests for amendments or extensions of active permits. 767.8 Section 767.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... extensions of active permits. (a) Requests for amendments to active permits (e.g., a change in study...

  19. 32 CFR 767.8 - Requests for amendments or extensions of active permits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Requests for amendments or extensions of active permits. 767.8 Section 767.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... extensions of active permits. (a) Requests for amendments to active permits (e.g., a change in study...

  20. 32 CFR 767.8 - Requests for amendments or extensions of active permits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Requests for amendments or extensions of active permits. 767.8 Section 767.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY... extensions of active permits. (a) Requests for amendments to active permits (e.g., a change in study...

  1. A National Perspective on the Current Evaluation Activities in Extension

    ERIC Educational Resources Information Center

    Lamm, Alexa J.; Israel, Glenn D.; Diehl, David

    2013-01-01

    In order to enhance Extension evaluation efforts it is important to understand current practices. The study reported here researched the evaluation behaviors of county-based Extension professionals. Extension professionals from eight states (n = 1,173) responded to a survey regarding their evaluation data collection, analysis, and reporting…

  2. Comparison of trunk and hip muscle activity during different degrees of lumbar and hip extension.

    PubMed

    Kim, Sang-Min; Yoo, Won-Gyu

    2015-09-01

    [Purpose] This study compared the activity of trunk and hip muscles during different degrees of lumbar and hip extension. [Subjects] The study enrolled 18 participants. [Methods] Two exercises (hip and lumbar extension) and two ranges (180° and <180°) were studied. [Results] Differences in degree of extension affected the percentage maximal voluntary isometric contraction of the lumbar erector spinae and biceps femoris muscles, with significantly higher average values at >180° than at 180° lumbar extension. No significant differences were found in gluteus maximus activity according to exercise type or range. [Conclusion] Hip extension may be more effective and safer for lumbar rehabilitation than lumbar extension.

  3. The Extension-Reduction Strategy: Activating Prior Knowledge

    ERIC Educational Resources Information Center

    Sloyer, Cliff W.

    2004-01-01

    A mathematical problem is solved using the extension-reduction or build it up-tear it down tactic. This technique is implemented in reviving students' earlier knowledge to enable them to apply this knowledge to solving new problems.

  4. Cornell OEO Project: An Exploration in Urban Extension Activity.

    ERIC Educational Resources Information Center

    Ostrander, Edward; And Others

    To explore ways of adapting cooperative extension education to help urban poor families solve their home management and consumer problems, the Cornell-OEO project trained and then employed 38 South Brooklyn women as family assistants to work with over 500 local families. The dynamic program changed frequently during its 2 year term as its range…

  5. Life Extension Activities for the Hubble Space Telescope

    NASA Technical Reports Server (NTRS)

    Walyus, Keith D.; Pepe, Joyce A. K.; Prior, Michael

    2004-01-01

    With the cancellation of the Hubble Space Telescope (HST) Servicing Mission 4 (SM4), the HST Project will face numerous challenges to keep the Telescope operating during the remainder of the decade. As part of the SM4, the HST Project had planned to install various upgrades to the Telescope including the installation of new batteries and new rate integrating gyros. Without these upgrades, reliability analysis indicates that the spacecraft will lose the capability to conduct science operations later this decade. The HST team will be severely challenged to maximize the Telescope's remaining operational lifetime, while still trying to maximize - its science output and quality. Two of the biggest areas of concern are the age and condition of the batteries and gyros. Together they offer the largest potential extension in Telescope lifetime and present the biggest challenges to the HST team. The six Ni-H batteries on HST are the original batteries from launch. With fourteen years of operational life, these batteries have collectively lasted longer than any other comparable mission. Yet as with all batteries, their capacity has been declining. Engineers are examining various methods to prolong the life of these mission critical batteries, and retard the rate of degradation. This paper will focus on these and other efforts to prolong the life of the HST, thus enabling it to remain a world-class observatory for as long as possible.

  6. Activities.

    ERIC Educational Resources Information Center

    Kincaid, Charlene; And Others

    1993-01-01

    Presents an activity in which students collect and organize data from a real-world simulation of the scientific concept of half life. Students collect data using a marble sifter, analyze the data using a graphing calculator, and determine an appropriate mathematical model. Includes reproducible worksheets. (MDH)

  7. 75 FR 77940 - Agency Information Collection Activities; Extension of a Currently-Approved Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Extension of a... AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice and request for comments... identify designated/restricted routes and restrictions or limitations affecting how motor carriers...

  8. 75 FR 61816 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA), DOT..., Federal Highway Administration, Department of Transportation, 1200 New Jersey Avenue, SE., Washington,...

  9. 75 FR 61814 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA), DOT..., Federal Highway Administration, Department of Transportation, 1200 New Jersey Avenue, SE., Washington,...

  10. 75 FR 52542 - Extension of Agency Information Collection Activity Under OMB Review: Department of Homeland...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... SECURITY Transportation Security Administration Extension of Agency Information Collection Activity Under OMB Review: Department of Homeland Security Traveler Redress Inquiry Program (DHS TRIP) AGENCY... submission of identifying and travel experience information by individuals requesting redress through...

  11. 75 FR 42817 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... to enhance the quality, usefulness, and clarity of the collected information; and (4) ways that the... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA),...

  12. 76 FR 12213 - Agency Information Collection Activities; Extension of an Approved Information Collection Request...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Extension of an Approved Information Collection Request: Household Goods Consumer Information Program Assessment Study... Information Collection Request (ICR) described below to the Office of Management and Budget (OMB) for...

  13. 75 FR 42817 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... of the burden of the proposed information collection; (3) ways to enhance the quality, usefulness... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA),...

  14. 75 FR 42816 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... enhance the quality, usefulness, and clarity of the collected information; and (4) ways that the burden... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA),...

  15. 75 FR 20875 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... enhance the quality, usefulness, and clarity of the collected information; and (4) ways that the burden... Federal Highway Administration Agency Information Collection Activities: Notice of Request for Extension of Currently Approved Information Collection AGENCY: Federal Highway Administration (FHWA),...

  16. 75 FR 63499 - Extension of Agency Information Collection Activity Under OMB Review: Sensitive Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... SECURITY Transportation Security Administration Extension of Agency Information Collection Activity Under OMB Review: Sensitive Security Information Threat Assessments AGENCY: Transportation Security... period soliciting comments, of the following collection of information on July 30, 2010 75 FR 44974....

  17. 78 FR 26057 - Extension of Agency Information Collection Activity Under OMB Review: Pipeline Corporate Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... SECURITY Transportation Security Administration Extension of Agency Information Collection Activity Under OMB Review: Pipeline Corporate Security Review AGENCY: Transportation Security Administration, DHS. ACTION: 30-day Notice. SUMMARY: This notice announces that the Transportation Security...

  18. 75 FR 70030 - Agency Information Collection Activities: Extension of a Currently Approved Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities: Extension of a Currently Approved... Department of Justice (DOJ), Bureau of Justice Statistics, will be submitting the following...

  19. 78 FR 45971 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of Currently Approved Collection; Bureau of Justice Assistance Application Form: Law...

  20. 77 FR 1727 - Agency Information Collection Activities: Proposed Collection; Comments Requested; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities: Proposed Collection; Comments Requested; Extension of Currently Approved Collection; Bureau of Justice Assistance Application Form: National...

  1. 78 FR 61868 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of Currently Approved Collection: Bureau of Justice Assistance Application Form; Law...

  2. 75 FR 4846 - Agency Information Collection Activities: Extension of a Previously Approved Collection; Comments...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... of Community Oriented Policing Services Agency Information Collection Activities: Extension of a Previously Approved Collection; Comments Requested ACTION: 30-Day Notice of Information Collection Under Review: COPS Hiring Recovery Program (CHRP) Progress Report. The Department of Justice (DOJ) Office...

  3. 76 FR 62818 - Extension of Agency Information Collection Activity Under OMB Review: Critical Facility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... operators on facility security policies, procedures, and physical security measures. Information obtained on... SECURITY Transportation Security Administration Extension of Agency Information Collection Activity Under OMB Review: Critical Facility Information of the Top 100 Most Critical Pipelines...

  4. 77 FR 5868 - Agency Information Collection Activities; Extension of a Currently Approved Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Extension of a Currently Approved Information Collection: Motor Carrier Identification Report AGENCY: Federal Motor Carrier... the Paperwork Reduction Act of 1995, FMCSA announces its plan to submit the Information...

  5. 75 FR 49946 - National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... National Drug Intelligence Center: Agency Information Collection Activities: Proposed Extension With Change... Response System. The United States Department of Justice (DOJ), National Drug Intelligence Center (NDIC... Intelligence Center, Fifth Floor, 319 Washington Street, Johnstown, PA 15901. Written comments and...

  6. 78 FR 5504 - Agency Information Collection Activities: Extension of Information Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... NATIONAL INTELLIGENCE Agency Information Collection Activities: Extension of Information Collection; Comment Request AGENCY: Office of the Director of National Intelligence (ODNI). ACTION: Notice and comment... are directly related to responsibilities assigned to the Director of National Intelligence (DNI)...

  7. 77 FR 56636 - Commission Information Collection Activities (FERC-500 & FERC-505); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Commission Information Collection Activities (FERC-500 & FERC- 505); Comment Request; Extension AGENCY: Federal Energy Regulatory Commission. ACTION: Notice of information...

  8. 76 FR 2420 - Agency Information Collection Activities: Extension of Existing Information Collection; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ...' Employment and Training Service Agency Information Collection Activities: Extension of Existing Information Collection; Comment Request AGENCY: Veterans' Employment and Training Service. ACTION: 60-Day Notice of... respondents can be properly assessed. Currently, the Veterans' Employment and Training Service (VETS)...

  9. 77 FR 71018 - Agency Information Collection Activities; Extension of a Currently Approved Collection; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-28

    ... Office of Juvenile Justice and Delinquency Prevention Agency Information Collection Activities; Extension... Juvenile Justice and Delinquency Prevention, Office of Justice Programs, Department of Justice. ACTION: 30... the collection: The Office of Juvenile Justice and Delinquency Prevention, Office of Justice...

  10. Assessing Adult Leisure Activities: An Extension of a Self-Report Activity Questionnaire

    ERIC Educational Resources Information Center

    Jopp, Daniela S.; Hertzog, Christopher

    2010-01-01

    Everyday leisure activities in adulthood and old age have been investigated with respect to constructs such as successful aging, an engaged lifestyle, and prevention of age-related cognitive decline. They also relate to mental health and have clinical value, as they can inform diagnosis and interventions. In the present study, the authors enhanced…

  11. Posterior muscle chain activity during various extension exercises: an observational study

    PubMed Central

    2013-01-01

    Background Back extension exercises are often used in the rehabilitation of low back pain. However, at present it is not clear how the posterior muscles are recruited during different types of extension exercises. Therefore, the present study will evaluate the myoelectric activity of thoracic, lumbar and hip extensor muscles during different extension exercises in healthy persons. Based on these physiological observations we will make recommendations regarding the use of extensions exercises in clinical practice. Methods Fourteen healthy subjects performed four standardized extension exercises (dynamic trunk extension, dynamic-static trunk extension, dynamic leg extension, dynamic-static leg extension) in randomized order at an intensity of 60% of 1-RM (one repetition maximum). Surface EMG signals of Latissimus dorsi (LD), Longissimus thoracis pars thoracic (LTT) and lumborum (LTL), Iliocostalis lumborum pars thoracic (ILT) and lumborum (ILL), lumbar Multifidus (LM) and Gluteus Maximus (GM) were measured during the various exercises. Subsequently, EMG root mean square values were calculated and compared between trunk and leg extension exercises, as well as between a dynamic and dynamic-static performance using mixed model analysis. During the dynamic exercises a 2 second concentric contraction was followed by a 2 second eccentric contraction, whereas in the dynamic-static performance, a 5 second isometric interval was added in between the concentric and eccentric contraction phase. Results In general, the muscles of the posterior chain were recruited on a higher level during trunk extension (mean ± SD, 56.6 ± 30.8%MVC) compared to leg extension (47.4 ± 30.3%MVC) (p ≤ 0.001). No significant differences were found in mean muscle activity between dynamic and dynamic-static performances (p = 0.053). The thoracic muscles (LTT and ILT) were recruited more during trunk extension (64.9 ± 27.1%MVC) than during leg extension (54.2 ± 22.1%MVC) (p = 0.045) without

  12. Influence of Hip Joint Position on Muscle Activity during Prone Hip Extension with Knee Flexion

    PubMed Central

    Suehiro, Tadanobu; Mizutani, Masatoshi; Okamoto, Mitsuhisa; Ishida, Hiroshi; Kobara, Kenichi; Fujita, Daisuke; Osaka, Hiroshi; Takahashi, Hisashi; Watanabe, Susumu

    2014-01-01

    [Purpose] This study investigated the selective activation of the gluteus maximus during a prone hip extension with knee flexion exercise, with the hip joint in different positions. [Subjects] The subjects were 21 healthy, male volunteers. [Methods] Activities of the right gluteus maximus, right hamstrings, bilateral lumbar erector spinae, and bilateral lumbar multifidus were measured using surface electromyography during a prone hip extension with knee flexion exercise. Measurements were made with the hip joint in each of 3 positions: (1) a neutral hip joint position, (2) an abduction hip joint position, and (3) an abduction with external rotation hip joint position. [Results] Gluteus maximus activity was significantly higher when the hip was in the abduction with external rotation hip joint position than when it was in the neutral hip joint and abduction hip joint positions. Gluteus maximus activity was also significantly higher in the abduction hip joint position than in the neutral hip joint position. Hamstring activity was significantly lower when the hip was in the abduction with external rotation hip joint position than when it was in the neutral hip joint and abduction hip joint positions. [Conclusion] Abduction and external rotation of the hip during prone hip extension with knee flexion exercise selectively activates the gluteus maximus. PMID:25540492

  13. 7 CFR 3400.22 - Merit review for education and extension activities.

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  1. 76 FR 43335 - Agency Information Collection Activities: Form I-765, Extension of a Currently Approved...

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  7. 78 FR 12789 - Agency Information Collection Activities; Extension of a Currently Approved Collection: Office on...

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    Federal Register 2010, 2011, 2012, 2013, 2014

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  10. 75 FR 70016 - Agency Information Collection Activities: Form I-290B, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-290B, Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection under Review: Form I- 290B,...

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-612; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review; Form I-...

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  13. 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans.

    PubMed

    Chondrogianni, Niki; Georgila, Konstantina; Kourtis, Nikos; Tavernarakis, Nektarios; Gonos, Efstathios S

    2015-02-01

    Protein homeostasis (proteostasis) is one of the nodal points that need to be preserved to retain physiologic cellular/organismal balance. The ubiquitin-proteasome system (UPS) is responsible for the removal of both normal and damaged proteins, with the proteasome being the downstream effector. The proteasome is the major cellular protease with progressive impairment of function during aging and senescence. Despite the documented age-retarding properties of proteasome activation in various cellular models, simultaneous enhancement of the 20S core proteasome content, assembly, and function have never been reported in any multicellular organism. Consequently, the possible effects of the core proteasome modulation on organismal life span are elusive. In this study, we have achieved activation of the 20S proteasome at organismal level. We demonstrate enhancement of proteasome levels, assembly, and activity in the nematode Caenorhabditis elegans, resulting in life span extension and increased resistance to stress. We also provide evidence that the observed life span extension is dependent on the transcriptional activity of Dauer formation abnormal/Forkhead box class O (DAF-16/FOXO), skinhead-1 (SKN-1), and heat shock factor-1 (HSF-1) factors through regulation of downstream longevity genes. We further show that the reported beneficial effects are not ubiquitous but they are dependent on the genetic context. Finally, we provide evidence that proteasome core activation might be a potential strategy to minimize protein homeostasis deficiencies underlying aggregation-related diseases, such as Alzheimer's disease (AD) or Huntington's disease (HD). In summary, this is the first report demonstrating that 20S core proteasome up-regulation in terms of both content and activity is feasible in a multicellular eukaryotic organism and that in turn this modulation promotes extension of organismal health span and life span. PMID:25395451

  14. Non-extensivity and complexity in the earthquake activity at the West Corinth rift (Greece)

    NASA Astrophysics Data System (ADS)

    Michas, Georgios; Vallianatos, Filippos; Sammonds, Peter

    2013-04-01

    Earthquakes exhibit complex phenomenology that is revealed from the fractal structure in space, time and magnitude. For that reason other tools rather than the simple Poissonian statistics seem more appropriate to describe the statistical properties of the phenomenon. Here we use Non-Extensive Statistical Physics [NESP] to investigate the inter-event time distribution of the earthquake activity at the west Corinth rift (central Greece). This area is one of the most seismotectonically active areas in Europe, with an important continental N-S extension and high seismicity rates. NESP concept refers to the non-additive Tsallis entropy Sq that includes Boltzmann-Gibbs entropy as a particular case. This concept has been successfully used for the analysis of a variety of complex dynamic systems including earthquakes, where fractality and long-range interactions are important. The analysis indicates that the cumulative inter-event time distribution can be successfully described with NESP, implying the complexity that characterizes the temporal occurrences of earthquakes. Further on, we use the Tsallis entropy (Sq) and the Fischer Information Measure (FIM) to investigate the complexity that characterizes the inter-event time distribution through different time windows along the evolution of the seismic activity at the West Corinth rift. The results of this analysis reveal a different level of organization and clusterization of the seismic activity in time. Acknowledgments. GM wish to acknowledge the partial support of the Greek State Scholarships Foundation (IKY).

  15. Correlated activity of cortical neurons survives extensive removal of feedforward sensory input

    PubMed Central

    Shapcott, Katharine A.; Schmiedt, Joscha T.; Saunders, Richard C.; Maier, Alexander; Leopold, David A.; Schmid, Michael C.

    2016-01-01

    A fundamental property of brain function is that the spiking activity of cortical neurons is variable and that some of this variability is correlated between neurons. Correlated activity not due to the stimulus arises from shared input but the neuronal circuit mechanisms that result in these noise correlations are not fully understood. Here we tested in the visual system if correlated variability in mid-level area V4 of visual cortex is altered following extensive lesions of primary visual cortex (V1). To this end we recorded longitudinally the neuronal correlations in area V4 of two behaving macaque monkeys before and after a V1 lesion while the monkeys fixated a grey screen. We found that the correlations of neuronal activity survived the lesions in both monkeys. In one monkey, the correlation of multi-unit spiking signals was strongly increased in the first week post-lesion, while in the second monkey, correlated activity was slightly increased, but not greater than some week-by-week fluctuations observed. The typical drop-off of inter-neuronal correlations with cortical distance was preserved after the lesion. Therefore, as V4 noise correlations remain without feedforward input from V1, these results suggest instead that local and/or feedback input seem to be necessary for correlated activity. PMID:27721468

  16. Muscle activity patterns during quick increase of movement amplitude in rapid elbow extensions.

    PubMed

    Takatoku, Nozomi; Fujiwara, Motoko

    2010-04-01

    In this study, we investigated a motor strategy for increasing the amplitude of movement in rapid extensions at the elbow joint. This study focused on the changes in a triphasic electromyographic (EMG) pattern, i.e., the first agonist burst (AG1), the second agonist burst (AG2) and the antagonist burst (ANT), for increasing the amplitude of movement required after the initiation of movement. Subjects performed 40 degrees (Basic task) and 80 degrees of extension (Wide task). These tasks were performed under two conditions; performing a predetermined task (SF condition) and performing a task in response to a visual stimulus immediately after movement commencement (ST condition). Kinematic parameters and EMG activity from the agonist (triceps brachii) and the antagonist (biceps brachii) muscles were recorded. As a result, the onset latency of AG1 and AG2 and the duration of AG1 were longer under the ST condition than the SF condition. No difference was observed between the SF and ST condition with respect to ANT activity. It is concluded that the motor strategy for increasing the amplitude of movement after the initiation of movement was to control the movement velocity and the timing to stop movement by the coactivation duration of AG1 and ANT and to stop the desired position accurately by AG2 activity.

  17. Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain

    PubMed Central

    1995-01-01

    Overexpression in insect cells of the full coding sequence of the human membrane cytoskeletal linker ezrin (1-586) was compared with that of a NH2-terminal domain (ezrin 1-233) and that of a COOH-terminal domain (ezrin 310-586). Ezrin (1-586), as well as ezrin (1-233) enhanced cell adhesion of infected Sf9 cells without inducing gross morphological changes in the cell structure. Ezrin (310-586) enhanced cell adhesion and elicited membrane spreading followed by microspike and lamellipodia extensions by mobilization of Sf9 cell actin. Moreover some microspikes elongated into thin processes, up to 200 microns in length, resembling neurite outgrowths by a mechanism requiring microtubule assembly. Kinetics of videomicroscopic and drug-interference studies demonstrated that mobilization of actin was required for tubulin assembly to proceed. A similar phenotype was observed in CHO cells when a comparable ezrin domain was transiently overexpressed. The shortest domain promoting cell extension was localized between residues 373-586. Removal of residues 566-586, involved in in vitro actin binding (Turunen, O., T. Wahlstrom, and A. Vaheri. 1994. J. Cell Biol. 126:1445- 1453), suppressed the extension activity. Coexpression of ezrin (1-233) with ezrin (310-586) in the same insect cells blocked the constitutive activity of ezrin COOH-terminal domain. The inhibitory activity was mapped within ezrin 115 first NH2-terminal residues. We conclude that ezrin has properties to promote cell adhesion, and that ezrin NH2- terminal domain negatively regulates membrane spreading and elongation properties of ezrin COOH-terminal domain. PMID:7896873

  18. Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease).

    PubMed Central

    Jansen, J. H.; Høgåsen, K.; Mollnes, T. E.

    1993-01-01

    Massive glomerular deposits of C3 and the terminal C5b-9 complement complex (TCC), but no immune complex deposits were detected by immunofluorescence in porcine membranoproliferative glomerulonephritis type II. TCC deposits were always observed with concomitant deposits of vitronectin (S-protein) in membranoproliferative glomerulonephritis, in contrast to a piglet with mesangial glomerulopathy where TCC was present without vitronectin co-deposition. Enzyme immunoassays revealed extensive systemic complement activation in 1-week-old affected piglets, observed by low plasma C3 (about 5% of normal) and high plasma TCC (about 10 x normal). Affected piglets revealed some plasma complement activation already at birth, 3 to 4 weeks before recognizable clinical disease. It is concluded that porcine membranoproliferative glomerulonephritis represents a nonimmune complex-mediated glomerulonephritis caused by unrestricted systemic complement activation with C3 consumption, TCC formation, and glomerular trapping of complement activation products. A pathogenetic mechanism of a defective or missing complement regulation protein is suggested. Images Figure 1 Figure 2 Figure 3 PMID:8238252

  19. Exploring the Gap for Effective Extension of Professional Active Life in Europe

    NASA Astrophysics Data System (ADS)

    Leonard, Will; Afsarmanesh, Hamideh; Msanjila, Simon S.; Playfoot, Jim

    Extending Professional Active Life (ePAL [2]) of elder people in Europe is affected by a number of factors in the market and society, which have the potential to either positively and negatively influence it. Current practices indicate that the European society, while started to act on this subject, is still slow to recognize the rationale behind and importance of fully supporting the extension of active professional life of seniors. Similarly, the capacity of the service sector to fully support the involvement of seniors in economical activities is at present limited, given the huge number of these seniors in different countries who need to be mobilized. This paper seeks to highlight the identified gaps related to effective mechanisms by which Europe can support its willing senior professionals to remain active. The study on gap identification addresses relevant technological, social, and organizational factors and external influences which have the potential to impact successful future life of elderly population. It also presents the methodology that is applied in our study to identify and analyze the gaps between the current practices in this area, the so-called baseline [2], and the desired future for this area as inspired in the ePAL vision [1] addressed in other research.

  20. Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity

    PubMed Central

    Yamauchi, Ken; Varadarajan, Supraja G.; Li, Joseph E.; Butler, Samantha J.

    2013-01-01

    Bone morphogenetic proteins (BMPs) have unexpectedly diverse activities establishing different aspects of dorsal neural circuitry in the developing spinal cord. Our recent studies have shown that, in addition to spatially orienting dorsal commissural (dI1) axons, BMPs supply ‘temporal’ information to commissural axons to specify their rate of growth. This information ensures that commissural axons reach subsequent signals at particular times during development. However, it remains unresolved how commissural neurons specifically decode this activity of BMPs to result in their extending axons at a specific speed through the dorsal spinal cord. We have addressed this question by examining whether either of the type I BMP receptors (Bmpr), BmprIa and BmprIb, have a role controlling the rate of commissural axon growth. BmprIa and BmprIb exhibit a common function specifying the identity of dorsal cell fate in the spinal cord, whereas BmprIb alone mediates the ability of BMPs to orient axons. Here, we show that BmprIb, and not BmprIa, is additionally required to control the rate of commissural axon extension. We have also determined the intracellular effector by which BmprIb regulates commissural axon growth. We show that BmprIb has a novel role modulating the activity of the actin-severing protein cofilin. These studies reveal the mechanistic differences used by distinct components of the canonical Bmpr complex to mediate the diverse activities of the BMPs. PMID:23250207

  1. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation

    PubMed Central

    Johmura, Yoshikazu; Yamashita, Emiri; Shimada, Midori; Nakanishi, Keiko; Nakanishi, Makoto

    2016-01-01

    Susceptibility to senescence caused by defective DNA repair is a major hallmark of progeroid syndrome patients, but molecular mechanisms of how defective DNA repair predisposes to senescence are largely unknown. We demonstrate here that suppression of DNA repair pathways extends the duration of Chk1-dependent G2 checkpoint activation and sensitizes cells to senescence through enhancement of mitosis skipping. Extension of G2 checkpoint activation by introduction of the TopBP1 activation domain and the nondegradable mutant of Claspin sensitizes cells to senescence. In contrast, a shortening of G2 checkpoint activation by expression of SIRT6 or depletion of OTUB2 reduces susceptibility to senescence. Fibroblasts from progeroid syndromes tested shows a correlation between an extension of G2 checkpoint activation and an increase in the susceptibility to senescence. These results suggest that extension of G2 checkpoint activation caused by defective DNA repair is critical for senescence predisposition in progeroid syndrome patients. PMID:27507734

  2. The influence of ankle sprain injury on muscle activation during hip extension.

    PubMed

    Bullock-Saxton, J E; Janda, V; Bullock, M I

    1994-08-01

    The likely influence of a localised injury in a distal joint on the function of proximal muscles is an important consideration in assessment and treatment of musculoskeletal injuries. However, little experimental evidence in humans exists in this area. Accordingly, a controlled study was carried out, in which the function of muscles at the hip was compared between subjects who had suffered previous severe unilateral ankle sprain and matched control subjects. The pattern of activation of the gluteus maximus, the hamstring muscles and the ipsilateral and contralateral erector spinae muscles was monitored through the use of surface electromyography during hip extension from prone lying. Analyses revealed that the pattern of muscle activation in subjects with previous injury differed markedly from normal control subjects, and that changes appeared to occur on both the uninjured and the injured sides of the body. A significant difference between the two groups was the delay in onset of activation of the gluteus maximus in previously injured subjects. The existence of remote changes in muscle function following injury found in this study emphasise the importance of extending assessment beyond the side and site of injury.

  3. Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.

    PubMed

    Sunden, Fanny; Peck, Ariana; Salzman, Julia; Ressl, Susanne; Herschlag, Daniel

    2015-01-01

    Enzymes enable life by accelerating reaction rates to biological timescales. Conventional studies have focused on identifying the residues that have a direct involvement in an enzymatic reaction, but these so-called 'catalytic residues' are embedded in extensive interaction networks. Although fundamental to our understanding of enzyme function, evolution, and engineering, the properties of these networks have yet to be quantitatively and systematically explored. We dissected an interaction network of five residues in the active site of Escherichia coli alkaline phosphatase. Analysis of the complex catalytic interdependence of specific residues identified three energetically independent but structurally interconnected functional units with distinct modes of cooperativity. From an evolutionary perspective, this network is orders of magnitude more probable to arise than a fully cooperative network. From a functional perspective, new catalytic insights emerge. Further, such comprehensive energetic characterization will be necessary to benchmark the algorithms required to rationally engineer highly efficient enzymes. PMID:25902402

  4. Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.

    PubMed

    Sunden, Fanny; Peck, Ariana; Salzman, Julia; Ressl, Susanne; Herschlag, Daniel

    2015-01-01

    Enzymes enable life by accelerating reaction rates to biological timescales. Conventional studies have focused on identifying the residues that have a direct involvement in an enzymatic reaction, but these so-called 'catalytic residues' are embedded in extensive interaction networks. Although fundamental to our understanding of enzyme function, evolution, and engineering, the properties of these networks have yet to be quantitatively and systematically explored. We dissected an interaction network of five residues in the active site of Escherichia coli alkaline phosphatase. Analysis of the complex catalytic interdependence of specific residues identified three energetically independent but structurally interconnected functional units with distinct modes of cooperativity. From an evolutionary perspective, this network is orders of magnitude more probable to arise than a fully cooperative network. From a functional perspective, new catalytic insights emerge. Further, such comprehensive energetic characterization will be necessary to benchmark the algorithms required to rationally engineer highly efficient enzymes.

  5. Nuclear Energy Gradients for Internally Contracted Complete Active Space Second-Order Perturbation Theory: Multistate Extensions.

    PubMed

    Vlaisavljevich, Bess; Shiozaki, Toru

    2016-08-01

    We report the development of the theory and computer program for analytical nuclear energy gradients for (extended) multistate complete active space perturbation theory (CASPT2) with full internal contraction. The vertical shifts are also considered in this work. This is an extension of the fully internally contracted CASPT2 nuclear gradient program recently developed for a state-specific variant by us [MacLeod and Shiozaki, J. Chem. Phys. 2015, 142, 051103]; in this extension, the so-called λ equation is solved to account for the variation of the multistate CASPT2 energies with respect to the change in the amplitudes obtained in the preceding state-specific CASPT2 calculations, and the Z vector equations are modified accordingly. The program is parallelized using the MPI3 remote memory access protocol that allows us to perform efficient one-sided communication. The optimized geometries of the ground and excited states of a copper corrole and benzophenone are presented as numerical examples. The code is publicly available under the GNU General Public License.

  6. Nuclear Energy Gradients for Internally Contracted Complete Active Space Second-Order Perturbation Theory: Multistate Extensions.

    PubMed

    Vlaisavljevich, Bess; Shiozaki, Toru

    2016-08-01

    We report the development of the theory and computer program for analytical nuclear energy gradients for (extended) multistate complete active space perturbation theory (CASPT2) with full internal contraction. The vertical shifts are also considered in this work. This is an extension of the fully internally contracted CASPT2 nuclear gradient program recently developed for a state-specific variant by us [MacLeod and Shiozaki, J. Chem. Phys. 2015, 142, 051103]; in this extension, the so-called λ equation is solved to account for the variation of the multistate CASPT2 energies with respect to the change in the amplitudes obtained in the preceding state-specific CASPT2 calculations, and the Z vector equations are modified accordingly. The program is parallelized using the MPI3 remote memory access protocol that allows us to perform efficient one-sided communication. The optimized geometries of the ground and excited states of a copper corrole and benzophenone are presented as numerical examples. The code is publicly available under the GNU General Public License. PMID:27388038

  7. Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity

    PubMed Central

    Markovitz, Craig D.; Hogan, Patrick S.; Wesen, Kyle A.; Lim, Hubert H.

    2015-01-01

    Objective The corticofugal system can alter coding along the ascending sensory pathway. Within the auditory system, electrical stimulation of the auditory cortex (AC) paired with a pure tone can cause egocentric shifts in the tuning of auditory neurons, making them more sensitive to the pure tone frequency. Since tinnitus has been linked with hyperactivity across auditory neurons, we sought to develop a new neuromodulation approach that could suppress a wide range of neurons rather than enhance specific frequency-tuned neurons. Approach We performed experiments in the guinea pig to assess the effects of cortical stimulation paired with broadband noise (PN-Stim) on ascending auditory activity within the central nucleus of the inferior colliculus (CNIC), a widely studied region for AC stimulation paradigms. Main results All eight stimulated AC regions induced extensive suppression of activity across the CNIC that was not possible with noise stimulation alone. This suppression built up over time and remained after the PN-Stim paradigm. Significance We propose that the corticofugal system is designed to decrease the brain’s input gain to irrelevant stimuli and PN-Stim is able to artificially amplify this effect to suppress neural firing across the auditory system. The PN-Stim concept may have potential for treating tinnitus and other neurological disorders. PMID:25686163

  8. Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity

    NASA Astrophysics Data System (ADS)

    Markovitz, Craig D.; Hogan, Patrick S.; Wesen, Kyle A.; Lim, Hubert H.

    2015-04-01

    Objective. The corticofugal system can alter coding along the ascending sensory pathway. Within the auditory system, electrical stimulation of the auditory cortex (AC) paired with a pure tone can cause egocentric shifts in the tuning of auditory neurons, making them more sensitive to the pure tone frequency. Since tinnitus has been linked with hyperactivity across auditory neurons, we sought to develop a new neuromodulation approach that could suppress a wide range of neurons rather than enhance specific frequency-tuned neurons. Approach. We performed experiments in the guinea pig to assess the effects of cortical stimulation paired with broadband noise (PN-Stim) on ascending auditory activity within the central nucleus of the inferior colliculus (CNIC), a widely studied region for AC stimulation paradigms. Main results. All eight stimulated AC subregions induced extensive suppression of activity across the CNIC that was not possible with noise stimulation alone. This suppression built up over time and remained after the PN-Stim paradigm. Significance. We propose that the corticofugal system is designed to decrease the brain’s input gain to irrelevant stimuli and PN-Stim is able to artificially amplify this effect to suppress neural firing across the auditory system. The PN-Stim concept may have potential for treating tinnitus and other neurological disorders.

  9. Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

    PubMed

    Horita, Yasuhiro; Takii, Takemasa; Yagi, Tetsuya; Ogawa, Kenji; Fujiwara, Nagatoshi; Inagaki, Emi; Kremer, Laurent; Sato, Yasuo; Kuroishi, Ryuji; Lee, Yoosa; Makino, Toshiaki; Mizukami, Hajime; Hasegawa, Tomohiro; Yamamoto, Ryuji; Onozaki, Kikuo

    2012-08-01

    The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB. PMID:22615274

  10. Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates

    PubMed Central

    Horita, Yasuhiro; Yagi, Tetsuya; Ogawa, Kenji; Fujiwara, Nagatoshi; Inagaki, Emi; Kremer, Laurent; Sato, Yasuo; Kuroishi, Ryuji; Lee, YooSa; Makino, Toshiaki; Mizukami, Hajime; Hasegawa, Tomohiro; Yamamoto, Ryuji; Onozaki, Kikuo

    2012-01-01

    The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB. PMID:22615274

  11. 38 CFR 21.46 - Veteran ordered to active duty; extension of basic period of eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Veteran ordered to active... Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Periods of Eligibility § 21.46 Veteran ordered to active... active duty under 10 U.S.C. 688, 12301(a), 12301(d), 12301(g), 12302, or 12304, the veteran's...

  12. 38 CFR 21.46 - Veteran ordered to active duty; extension of basic period of eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Veteran ordered to active... Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Periods of Eligibility § 21.46 Veteran ordered to active... active duty under 10 U.S.C. 688, 12301(a), 12301(d), 12301(g), 12302, or 12304, the veteran's...

  13. 77 FR 77067 - Commission Information Collection Activities (FERC Form No. 556); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ...-8659 for TTY. Docket: Users interested in receiving automatic notification of activity in this docket... transmission services priced on a nondiscriminatory basis; Operate in ``parallel'' with other...

  14. Electrically-activated source extension graphene nanoribbon field effect transistor: Novel attributes and design considerations for suppressing short channel effects

    NASA Astrophysics Data System (ADS)

    Naderi, Ali; Keshavarzi, Parviz

    2014-08-01

    In this paper a double gate graphene nanoribbon field effect transistor with electrically-activated source extension is proposed. Source region of the proposed structure includes two sections, an electrically-activated extension and a doped section. The electrically extension, which is located between doped source section and gate region, is biased independent of the gate to form a virtual extension for source. The electrically-activated extension creates a step in potential profile which increases the horizontal distance between conduction and valance bands at channel to source junction. This step reduces the probability of band to band tunneling, lowers the leakage current and improves drain induced barrier lowering. The devices have been simulated based on self consistent solution of Poisson and Schrodinger equations within non-equilibrium Green's function formalism. In addition, the effects of the edge and third nearest neighbor are included for more accurate outcomes. Simulations show that the proposed structure is a more reliable device because of its higher ON/Off current ratio, shorter delay time, and smaller power delay product beside lower subthreshold swing than conventional graphene nanoribbon field effect transistor.

  15. Read Alouds and Beyond: The Effects of Read Aloud Extension Activities on Vocabulary in Head Start Classrooms

    ERIC Educational Resources Information Center

    Silverman, Rebecca; Crandell, Jennifer DiBara; Carlis, Lydia

    2013-01-01

    A study was conducted in 26 Head Start classrooms with 264 children to compare the effect of a read aloud plus extension activities intervention over a control group to the effect of a read aloud only intervention over a control group on preschool children's vocabulary. Children were assessed before and after the intervention on target vocabulary…

  16. 75 FR 18545 - MMS Information Collection Activity: 1010-0067, Oil and Gas Well-Completion Operations, Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... Minerals Management Service MMS Information Collection Activity: 1010-0067, Oil and Gas Well- Completion.... ACTION: Notice of extension of an information collection (1010-0067). SUMMARY: To comply with the...; 381 Elden Street, MS-4024; Herndon, Virginia 20170-4817. Please reference ICR 1010-0067 in...

  17. 75 FR 65499 - Agency Information Collection Activities: Form I-600/I-600A, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... published in the Federal Register on June 23, 2010, at 75 FR 35824, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-600/ I-600A, Extension of a Currently Approved Information Collection; Comment Request ACTION: 30-Day...

  18. 75 FR 35824 - Agency Information Collection Activities: Forms I-600/I-600A, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

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  19. 75 FR 28052 - MMS Information Collection Activity: 1010-0051, Oil and Gas Production Measurement, Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

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  20. 77 FR 76015 - Commission Information Collection Activities (FERC-607); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... (EPAct 2005) modified FERC's role in order to better coordinate the activities of the separate agencies with varying responsibilities over proposed natural gas projects. Section 313 of EPAct 2005 \\1\\...

  1. 75 FR 24721 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

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  2. 75 FR 53322 - Agency Information Collection Activities: Extension of an Existing Information Collection...

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  3. 75 FR 24720 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... Immigration and Customs Enforcement (USICE), has submitted the following information collection request for review and clearance in accordance with the Paperwork Reduction Act of 1995. The information...

  4. 75 FR 2881 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...-0026. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), has submitted the following information collection request for review and clearance in accordance with...

  5. 77 FR 37063 - Agency Information Collection Activities: Extension, Without Change, of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

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  6. 77 FR 66862 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

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  7. 76 FR 72210 - Agency Information Collection Activities: Extension of an Information Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... Immigration and Customs Enforcement (ICE), is submitting the following information collection request for... United States Immigration and Customs Enforcement, Department of Homeland Security, and sent...

  8. 78 FR 42802 - Agency Information Collection Activities; Proposed Collection; Comments Requested Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Agency Information Collection Activities; Proposed Collection; Comments Requested... ACTION: 60-Day notice. The Department of Justice (DOJ), Office of Justice Programs, Bureau of...

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    Federal Register 2010, 2011, 2012, 2013, 2014

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Federal Bureau of Investigation Agency Information Collection Activities: Proposed Collection, Comments... Enforcement ACTION: 30-day Notice. The Department of Justice, Federal Bureau of Investigation, Criminal... collection: Form 1-725; Criminal Justice Information Services Division, Federal Bureau of......

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

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    Federal Register 2010, 2011, 2012, 2013, 2014

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  15. The Effect of Amorphization Conditions on the Measured Activation of Source Drain Extension Implants

    SciTech Connect

    England, Jonathan; Kontos, Alexander; Renau, Anthony; Gwilliam, Russell; Smith, Andrew; Knights, Andrew; Jain, Amitabh

    2008-11-03

    Un-patterned wafers were processed using low-dose Indium or medium-dose Germanium pre-amorphization implants (PAI) followed by p-type dopant implants of BF{sub 2} or carborane (CBH). The wafers were then annealed by RTA (spike), laser anneal (LSA) or combination of LSA and spike. Active dopant distributions calculated from SIMS and sheet resistance measurements compared favorably with those determined by differential Hall, which is a challenging technique for shallow profiles. The trends in B diffusion behavior and activation are discussed in relation to the different implant damage budgets, damage evolution during the anneals and presence of fluorine. In particular, for low thermal budget LSA only anneals, CBH implants appear to give higher activation than BF{sub 2} due to the absence of fluorine.

  16. Acute effects of blood flow restriction on muscle activity and endurance during fatiguing dynamic knee extensions at low load.

    PubMed

    Wernbom, Mathias; Järrebring, Rickard; Andreasson, Mikael A; Augustsson, Jesper

    2009-11-01

    The purpose of this study was to investigate muscle activity and endurance during fatiguing low-intensity dynamic knee extension exercise with and without blood flow restriction. Eleven healthy subjects with strength training experience performed 3 sets of unilateral knee extensions with no relaxation between repetitions to concentric torque failure at 30% of the 1 repetition maximum. One leg was randomized to exercise with cuff occlusion and the other leg to exercise without occlusion. The muscle activity in the quadriceps was recorded with electromyography (EMG). Ratings of perceived exertion (RPE) and acute pain were collected immediately, and delayed onset muscle soreness (DOMS) was rated before and at 24, 48, and 72 hours after exercise. The results demonstrated high EMG levels in both experimental conditions, but there were no significant differences regarding maximal muscle activity, except for a higher EMG in the eccentric phase in set 3 for the nonoccluded condition (p = 0.005). Significantly more repetitions were performed with the nonoccluded leg in every set (p < 0.05). The RPE and acute pain ratings were similar, but DOMS was higher in the nonoccluded leg (p < 0.05). We conclude that blood flow restriction during low-intensity dynamic knee extension decreases the endurance but does not increase the maximum muscle activity compared with training without restriction when both regimes are performed to failure. The high levels of muscle activity suggest that performing low-load dynamic knee extensions in a no-relaxation manner may be a useful method in knee rehabilitation settings when large forces are contraindicated. However, similarly to fatiguing blood flow restricted exercise, this method is associated with ischemic muscle pain, and thus its applications may be limited to highly motivated individuals.

  17. 76 FR 38410 - BOEMRE Information Collection Activity: 1010-0057, Pollution Prevention and Control, Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

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  18. 77 FR 31432 - Agency Information Collection; Activity Under OMB Review; Report of Extension of Credit to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Notice with a 60-day comment period was published on March 19, 2012 (77 FR 16116). The agency did not...; Report of Extension of Credit to Political Candidates AGENCY: Research & Innovative Technology... Extension of Credit to Political Candidates. Form No.: 183. ] Type of Review: Extension of a...

  19. 77 FR 38307 - Agency Information Collection Activities: Refugee/Asylee Relative Petition, Extension, Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Refugee/Asylee... Information Collection Under Review: Form I- 730, Refugee/Asylee Relative Petition; OMB Control No. 1615-0037.... (2) Title of the Form/Collection: Refugee/Asylee Relative Petition. (3) Agency form number, if...

  20. 77 FR 11147 - Agency Information Collection Activities: Extension, Without Change, of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

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  1. 77 FR 28369 - Commission Information Collection Activities (FERC-576); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ...) serious interruptions to service, and (3) damage to jurisdictional natural gas facilities due to natural disaster or terrorist activity, that creates the potential for serious delivery problems on the pipeline's... damaged; (4) The time the service interruption or damage to the facilities occurred; (5) The...

  2. 76 FR 32388 - Agency Information Collection Activities; Request for Comment; Extension of an Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ... Docket Management System published in the Federal Register on January 17, 2008 (73 FR 3316), or you may... duty status in a specified format and verify the accuracy of the HOS of each driver (47 FR 53383). The... Federal Motor Carrier Safety Administration Agency Information Collection Activities; Request for...

  3. Effect of Behavioral Activation Treatment on Chronic Fibromyalgia Pain: Replication and Extension

    ERIC Educational Resources Information Center

    Lundervold, Duane A.; Talley, Chris; Buermann, Michael

    2008-01-01

    A multiple-baseline-across two behavior sets and positions (reclined, upright) was used to experimentally examine the effect of Behavioral Activation Treatment for Pain (BAT-P) on pain-related behavior of a 44-year-old woman with a 22-year history of fibromyalgia (FM). BAT-P, based on the matching law, is comprised of Behavioral Relaxation…

  4. 76 FR 67158 - Commission Information Collection Activities (FERC-725F); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ....asp , to establish a user name and password before eFiling. The Commission will send an automatic... NE., Washington, DC 20426. Users interested in receiving automatic notification of activity in this... Standard NUC-001-2 is to require ``coordination between nuclear plant generator operators and...

  5. 77 FR 53877 - Commission Information Collection Activities (FERC-715); Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... public comment on the currently approved information collection, Annual Transmission Planning and...-8659 for TTY. Docket: Users interested in receiving automatic notification of activity in this docket...: Title: FERC-715: Annual Transmission Planning and Evaluation Report. OMB Control No.: 1902-0171. Type...

  6. 77 FR 23271 - Agency Information Collection Activities: Form I-881; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

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  7. 77 FR 3484 - Agency Information Collection Activities: Form I-914, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Federal Register on October 28, 2011, at 76 FR 66944, allowing for a 60-day public comment period. USCIS... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-914... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following...

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... published in the Federal Register on March 12, 2012, at 77 FR 14535, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-590... of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

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    2010-08-09

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    2012-03-19

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    2010-08-18

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    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... collection was previously published in the Federal Register on November 30, 2010, at 75 FR 74070, allowing... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-829... No. 1615-0045. The Department of Homeland Security, U.S. Citizenship and Immigration Services...

  14. 75 FR 47824 - Agency Information Collection Activities: Form I-643, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ..., 2010, at 75 FR 23784, allowing for a 60-day public comment period. USCIS did not receive any comments... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-643.../Asylee Adjusting Status; OMB Control No. 1615-0070. The Department of Homeland Security, U.S....

  15. 75 FR 51095 - Agency Information Collection Activities: Form N-336; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-336... Section 336; OMB Control No. 1615-0050. The Department of Homeland Security, U.S. Citizenship and... sponsoring the collection: Form N-336; U.S. Citizenship and Immigration Services (USCIS). (4) Affected...

  16. 76 FR 55081 - Agency Information Collection Activities: Form I-129S; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-129S... Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following... collection: Form I-129S; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will...

  17. 77 FR 27474 - Agency Information Collection Activities: Form I-687; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-687...-687. The Department Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS) has...-687; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will be asked...

  18. 75 FR 54646 - Agency Information Collection Activities: Form I-914; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-914.... Citizenship and Immigration Services (USCIS) will be submitting the following information collection request... of the Department of Homeland Security sponsoring the collection: Form I-914; U.S. Citizenship...

  19. 76 FR 58029 - Agency Information Collection Activities: Form N-600K, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... collection was previously published in the Federal Register on June 29, 2011, at 76 FR 38197, allowing for a... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-600K... Information Collection Under Review: Form N- 600K; Application for Citizenship and Issuance of...

  20. 75 FR 51094 - Agency Information Collection Activities: Form I-363, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    .... The information collection was previously published in the Federal Register on June 23, 2010, at 75 FR... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-363... Amerasian; OMB Control No. 1615-0022. The Department of Homeland Security, U.S. Citizenship and...

  1. 76 FR 12751 - Agency Information Collection Activities: Form I-589, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... information collection was previously published in the Federal Register on November 30, 2010, at 75 FR 74069... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-589... Control No. 1615-0067. The Department of Homeland Security, U.S. Citizenship and Immigration...

  2. 76 FR 27078 - Agency Information Collection Activities: Form N-426, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-426... Control No. 1615-0053. The Department of Homeland Security, U.S. Citizenship and Immigration Services.... Citizenship and Immigration Services. (4) Affected public who will be asked or required to respond, as well...

  3. 75 FR 51096 - Agency Information Collection Activities: Form N-470; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-470.... 1615-0056. The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will...: Form N-470; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will be asked...

  4. 76 FR 17144 - Agency Information Collection Activities: Form N-300; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-300.... The Department Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting... collection: Form N-300; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will...

  5. 77 FR 27473 - Agency Information Collection Activities: Form I-924; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-924... Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS) will be submitted... sponsoring the collection: Form I-924; U.S. Citizenship and Immigration Services. (4) Affected public...

  6. 77 FR 34398 - Agency Information Collection Activities: Form N-565, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ..., 2012, at 77 FR 18255, allowing for a 60-day public comment period. USCIS did not receive any comments... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-565... Information Collection Under Review: Form N- 565, Application for Replacement...

  7. 77 FR 12072 - Agency Information Collection Activities: Form I-824; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-824... Homeland Security, U.S. Citizenship and Immigration Services (USCIS) has submitted the following... collection: Form I-824; U.S. Citizenship and Immigration Services (USCIS). (4) Affected public who will...

  8. 76 FR 36560 - Agency Information Collection Activities; Form N-300; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... was previously published in the Federal Register on March 28, 2011 at 76 FR 17144, allowing for a 60... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities; Form N-300.... The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will...

  9. 77 FR 31033 - Agency Information Collection Activities: Form I-589, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... published in the Federal Register on March 19, 2012, at 77 FR 16047, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-589... Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

  10. 77 FR 23270 - Agency Information Collection Activities: Form I-290B, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... Register on February 7, 2012, at 77 FR 6134, allowing for a 60-day public comment period. USCIS received... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-290B.... Citizenship and Immigration Services (USCIS) will be ] submitting the following information collection...

  11. 75 FR 10298 - Agency Information Collection Activities: Form I-929; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... collection was previously published in the Federal Register on November 24, 2009, at 74 FR 61360, allowing... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-929... No. 1615-0106. The Department of Homeland Security, U.S. Citizenship and Immigration Services...

  12. 75 FR 39271 - Agency Information Collection Activities: Form I-694, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... Federal Register on April 22, 2010, at 75 FR 21014, allowing for a 60-day public comment period. USCIS did... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-694....S. Citizenship and Immigration Services (USCIS) will be submitting the following...

  13. 78 FR 5477 - Agency Information Collection Activities: InfoPass System, No Form Number; Extension, Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... information collection notice was previously published in the Federal Register on October 31, 2012, at 77 FR... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: InfoPass... Collection. (2) Title of the Form/Collection: InfoPass System. (3) Agency form number, if any, and...

  14. 75 FR 29780 - Agency Information Collection Activities: Form I-612, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ... the Federal Register on March 12, 2010, at 74 FR 11898, allowing for a 60-day public comment period... abstract: Primary: Individuals or Households. Form I- 612 is used by USCIS to determine eligibility for a... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form...

  15. 76 FR 66944 - Agency Information Collection Activities: Form I-914; Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Information Collection Under Review: Form I- 914 and Supplements A and B, Application for T Nonimmigrant... required to respond, as well as a brief abstract: Primary: Individuals or households. Form I- 914 permits... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form...

  16. 76 FR 71056 - Agency Information Collection Activities: Form I-566, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... Information Collection Under Review: Form I- 566, Interagency Record of Request, A, G or NATO Dependent... Federal Register on August 18, 2011, at 76 FR 51382, allowing for a 60-day public comment period. USCIS... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form...

  17. 76 FR 45845 - Agency Information Collection Activities: Form I-777, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... published in the Federal Register on May 19, 2011, at 76 FR 28800, allowing for a 60-day public comment...: Primary: Individuals or Households. Form I- 777 is used by applicants applying for a Northern Marina... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form...

  18. 78 FR 23577 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities... Officer, for United States Immigration and Customs Enforcement, Department of Homeland Security, and sent... Information Collection for Review; File No. I- 352, Immigration Bond; OMB Control No. 1653-0022....

  19. 77 FR 37063 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...: Primary: State, Local, or Tribal Government. Section 404(b) of the Immigration and Nationality Act (8 U.S.C. 1101 note) provides for the reimbursement to States and localities for assistance provided...

  20. 77 FR 42322 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...: State, Local, or Tribal Government. Section 404(b) of the Immigration and Nationality Act (8 U.S.C. 1101 note) provides for the reimbursement to States and localities for assistance provided in meeting...

  1. 75 FR 24721 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities... or school; and at the time they leave the United States. (5) An estimate of the total number of.... The Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), will...

  2. 75 FR 65022 - Agency Information Collection Activities: Form I-751, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... collection was previously published in the Federal Register on June 30, 2010, at 75 FR 37821, allowing for a... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-751.... 1615- 0038. The Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS)...

  3. 76 FR 60852 - Agency Information Collection Activities; Form I-130; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities; Form I-130... of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the... Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS), Chief,...

  4. 78 FR 45550 - Agency Information Collection Activities: Extension, Without Change, of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities.... 1653-0048. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (ICE), will... addressed to the OMB Desk Officer for U.S. Immigration and Customs Enforcement, Department of...

  5. 76 FR 31971 - Agency Information Collection Activities: Form I-212; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... on March 16, 2011, at 76 FR 14419, allowing for a 60-day public comment period. USCIS received no... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-212.... Citizenship and Immigration Services (USCIS) will be submitting the following information collection...

  6. 77 FR 3486 - Agency Information Collection Activities: Form I-539, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... previously published in the Federal Register on October 28, 2011, at 76 FR 66946, allowing for a 60-day... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-539... Department of Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting...

  7. 77 FR 3485 - Agency Information Collection Activities: Form I-129F, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Federal Register on October 28, 2011, at 76 FR 66944, allowing for a 60-day public comment period. USCIS... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-129F... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following...

  8. 76 FR 70747 - Agency Information Collection Activities: Form I-526, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... published in the Federal Register on August 12, 2011, at 76 FR 50238, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-526... Homeland Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the...

  9. 75 FR 16158 - Agency Information Collection Activities: Extension of an Existing Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... SECURITY United States Immigration and Customs Enforcement Agency Information Collection Activities...-0026. The Department of Homeland Security, U.S. Immigration and Customs Enforcement (USICE), has... should be addressed to OMB Desk Officer, for U. S. Immigration and Customs Enforcement, Department...

  10. 75 FR 65022 - Agency Information Collection Activities: Form I-698, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    .... The information collection was previously published in the Federal Register on June 23, 2010, at 75 FR... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-698... Resident; OMB Control No. 1615-0035. The Department of Homeland Security, U.S. Citizenship and...

  11. 76 FR 24908 - Agency Information Collection Activities: Form G-639; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-639... Collection Under Review; Form G- 639, Freedom of Information/Privacy Act Request; OMB Control No. 1615- 0102.... During this 60 day period, USCIS will be evaluating whether to revise the Form G-639. Should USCIS...

  12. 76 FR 48874 - Agency Information Collection Activities: Form G-884, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... the Federal Register on March 17, 2011, at 76 FR 28444, allowing for a 60- day public comment period... SECURITY Citizenship and Immigration Services Agency Information Collection Activities: Form G-884... Collection Under Review: Form G- 884, Request for the Return of Original Document(s). The Department...

  13. 76 FR 28444 - Agency Information Collection Activities: Form G-884, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-884... information collection under review: Form G- 884, Request for the Return of Original Documents; OMB Control No... July 18, 2011. During this 60-day period, USCIS will be evaluating whether to revise the Form...

  14. 75 FR 23785 - Agency Information Collection Activities: Form G-639; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form G-639... Collection Under Review; Form G- 639, Freedom of Information/Privacy Act Request; OMB Control No. 1615- 0102... this 60 day period, USCIS will be evaluating whether to revise the Form G-639. Should USCIS decide...

  15. 78 FR 44141 - Agency Information Collection Activities: Affidavit of Support, Form I-134; Extension, Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Affidavit of.... SUMMARY: The Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services (USCIS.... the time, effort, and resources used by the respondents to respond), the estimated cost to...

  16. 77 FR 65898 - Agency Information Collection Activities: InfoPass System, No Form Number; Extension, Without...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: InfoPass... Notice. SUMMARY: The Department of Homeland Security (DHS), U.S. Citizenship and Immigration Services...), the estimated cost to the respondent, and the actual information collection instruments....

  17. 76 FR 39415 - Agency Information Collection Activities: Form N-644, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... was previously published in the Federal Register on April 19, 2011, at 76 FR 21913, allowing for a 60... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Information Collection Under Review: Form N- 644, Application for Posthumous Citizenship; OMB Control No....

  18. 75 FR 21013 - Agency Information Collection Activities: Form N-644; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Collection Under Review; Form N- 644, Application for Posthumous Citizenship; OMB Control No. 1615-0059. The..., USCIS will be evaluating whether to revise the Form N-644. Should USCIS decide to revise Form N-644...

  19. 75 FR 70278 - Agency Information Collection Activities: Form N-600, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... collection was previously published in the Federal Register on August 18, 2010, at 75 FR 51094, allowing for... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-600... Information Collection Under Review: Form N- 600, Application for Certificate of Citizenship; OMB Control...

  20. 76 FR 45844 - Agency Information Collection Activities: Form N-426, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... published in the Federal Register on May 10, 2011, at 76 FR 27078, allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-426... Information Collection Under Review: Form N- 426, Request for Certification of Military or Naval Service....

  1. 75 FR 13776 - Agency Information Collection Activities: Form N-300; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-300... Collection Under Review; Form N- 300, Application to File Declaration of Intention; OMB Control No. 1615-0078... this 60-day period, USCIS will be evaluating whether to revise the Form N-300. Should USCIS decide...

  2. 76 FR 21913 - Agency Information Collection Activities: Form N-644; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Collection Under Review: Form N- 644, Application for Posthumous Citizenship; OMB Control No. 1615-0059. The..., USCIS will be evaluating whether to revise the Form N-644. Should USCIS decide to revise Form N-644...

  3. 75 FR 41216 - Agency Information Collection Activities: Form N-644, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... was previously published in the Federal Register on April 22, 2010, at 75 FR 21013, allowing for a 60... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form N-644... Information Collection Under Review: Form N- 644, Application for Posthumous Citizenship; OMB Control No....

  4. 76 FR 16393 - Commission Information Collection Activities, Proposed Collection; Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... downstream hydropower project owners. Headwater benefits is the additional energy production possible at a... annual cost per employee. The reporting burden includes the total time, effort, or financial resources... apply to activities which benefit the whole organization rather than any one particular function...

  5. Meanings Ascribed to Four Craft Activities before and after Extensive Learning.

    ERIC Educational Resources Information Center

    Katz, Noomi; Cohen, Esther

    1991-01-01

    A study to compare the meanings ascribed by 35 occupational therapy students to puppetry, woodworking, weaving, and ceramics revealed significant differences before and after learning, especially for puppetry. Significant differences were found across activities, mainly between weaving and the other crafts. (JOW)

  6. 76 FR 43336 - Agency Information Collection Activities: Form AR-11, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... published in the Federal Register on May 10, 2011, at 76 FR 27077 allowing for a 60-day public comment... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form AR-11... Collection under Review: Form AR- 11, Alien's Change of Address Card; OMB Control No. 1615-0007....

  7. Extensive and Diverse Submarine Volcanism and Hydrothermal Activity in the NE Lau Basin

    NASA Astrophysics Data System (ADS)

    Embley, R. W.; Merle, S. G.; Lupton, J. E.; Resing, J.; Baker, E. T.; Lilley, M. D.; Arculus, R. J.; Crowhurst, P. V.

    2009-12-01

    The northeast Lau basin, the NE “corner” of the Tonga subduction zone, has an unusual concentration of young submarine volcanism and hydrothermal activity. The area is bounded on the west by overlapping spreading centers opening at rates up to 120 mm/yr, on the north by the E-W trending Tonga trench and on the east by the Tofua arc front. From the south, the Fonualei rift spreading center (FRSC) overlaps with the southern rift of The Mangatolo triple junction spreading center (MTJSC). The northern arm of the MTJSC overlaps with the northeast Lau spreading center (NELSC). Surveys of the area with an EM300 sonar system in November 2008 show high backscatter over the 10-20 km wide neovolcanic zones of the FRSC, MTJSC and NELSC. High backscatter is also associated with: (1) a 10-km diameter, hydrothermally active, volcanic caldera/cone (Volcano “O”) lying between the NELSC and the northern Tofua arc front; (2) a rift zone extending north from volcano “O” and intersecting the NELSC near the Tonga trench; and (3) a series of volcanoes constructed along SW-NE trending crustal tears in the northernmost backarc near the east-west portion of the Tonga Trench. Two eruptions were detected in November 2008 during hydrothermal plume surveys of the area. Subsequent dives with the remotely operated vehicle Jason 2 in May 2009 revealed that the southern NELSC eruption was a short-lived, primarily effusive eruption. The second eruption was detected on the summit of the largest SW-NE trending volcano (West Mata) and was ongoing when Jason 2 arrived on site more than 6 months later. It was producing both pillow lavas and abundant volcaniclastic debris streams that have a characteristic appearance on the sonar backscatter map. There is also an unusual series of lava flows emanating from ridges and scarps between Volcano “O” and West Mata. These flows contain drained-out lava ponds up to 2 km in diameter. The apparent high level of volcanic activity in the NE Lau basin

  8. [Activities of university extension in an infant mortality prevention committee and health statistics].

    PubMed

    Mathias, Thais Aidar de Freitas; Uchimura, Taqueco Teruya; Assunção, Amanda Nolasco de; Predebon, Kelen Marja

    2009-01-01

    Extra classes' activities with the Committee of Infant Mortality Prevention of the 15th Paraná Health Office (15th HO) and some approaches to health statistics, are described. Those activities articulate a partnership between the Nursing Department of the State University of Maringá and the 15th HO. A description of the Committee's attributions, the advances since the partnership start, the importance of the infant mortality investigations as well as understanding the information systems are presented. There are still challenges such as to improve the quality of the inquiry form. The partnership University -15th HO improves the quality of the Information Systems, provides the students a wider perspective of the intra-urban inequalities to access to health services, stimulating their commitment with public health.

  9. The classification of sri lankan medicinal herbs: an extensive comparison of the antioxidant activities.

    PubMed

    Waisundara, Viduranga Y; Watawana, Mindani I

    2014-07-01

    Sri Lanka has variety of herbs whose effectiveness has been proven across many generations. These herbs are classified into two groups - 'heating' and 'cooling', based on the physiological reactions upon consumption. Application-wise, the 'cooling' herbs are administered to patients contracted with diabetes, imbalances in the lipid profile, or even cancer. However, this classification has been misunderstood due to inconsistent interpretations and lack of scientific reasoning. This study systematically determines the rationale behind this classification, by specifically evaluating the antioxidant activity of 18 herbs - nine herbs from each category. The oxygen radical absorbance capacities, DPPH radical scavenging activities, and the total phenolic contents are analyzed here. The 'heating' herbs have a comparatively lower antioxidant potential than the 'cooling' herbs. The total phenolic contents correlate with the antioxidant values. It can be hypothesized that the high antioxidant potential of the 'cooling' herbs may have been responsible for the containment of the diseases mentioned previously.

  10. 77 FR 41801 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ... Requested; Extension of a Currently Approved Collection; Bioterrorism Preparedness Act: Entity/Individual.... (2) The title of the form/collection: Federal Bureau of Investigation Bioterrorism Preparedness...

  11. 77 FR 56861 - Agency Information Collection Activities: Proposed Collection, Comments Requested Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Requested Extension of a Currently Approved Collection Bioterrorism Preparedness Act: Entity/Individual.../collection: Federal Bureau of Investigation Bioterrorism Preparedness Act: Entity/Individual Information....

  12. 77 FR 56862 - Agency Information Collection Activities: Proposed Collection, Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Requested; Extension of a Currently Approved Collection; Bioterrorism Preparedness Act: Entity/Individual.../collection: Federal Bureau of Investigation Bioterrorism Preparedness Act: Entity/Individual Information....

  13. 77 FR 56863 - Agency Information Collection Activities: Proposed Collection, Comments Requested Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Requested Extension of a Currently Approved Collection Bioterrorism Preparedness Act: Entity/Individual.../collection: Federal Bureau of Investigation Bioterrorism Preparedness Act: Entity/Individual Information....

  14. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.

    PubMed

    Lazarevic, Vesna; Schöne, Cornelia; Heine, Martin; Gundelfinger, Eckart D; Fejtova, Anna

    2011-07-13

    Global changes of activity in neuronal networks induce homeostatic adaptations of synaptic strengths, which involve functional remodeling of both presynaptic and postsynaptic apparatuses. Despite considerable advances in understanding cellular properties of homeostatic synaptic plasticity, the underlying molecular mechanisms are not fully understood. Here, we explored the hypothesis that adaptive homeostatic adjustment of presynaptic efficacy involves molecular remodeling of the release apparatus including the presynaptic cytomatrix, which spatially and functionally coordinates neurotransmitter release. We found significant downregulation of cellular expression levels of presynaptic scaffolding proteins Bassoon, Piccolo, ELKS/CAST, Munc13, RIM, liprin-α, and synapsin upon prolonged (48 h) activity depletion in rat neuronal cultures. This was accompanied by a general reduction of Bassoon, Piccolo, ELKS/CAST, Munc13, and synapsin levels at synaptic sites. Interestingly, RIM was upregulated in a subpopulation of synapses. At the level of individual synapses, RIM quantities correlated well with synaptic activity, and a constant relationship between RIM levels and synaptic activity was preserved upon silencing. Silencing also induced synaptic enrichment of other previously identified regulators of presynaptic release probability, i.e., synaptotagmin1, SV2B, and P/Q-type calcium channels. Seeking responsible cellular mechanisms, we revealed a complex role of the ubiquitin-proteasome system in the functional presynaptic remodeling and enhanced degradation rates of Bassoon and liprin-α upon silencing. Together, our data indicate a significant molecular reorganization of the presynaptic release apparatus during homeostatic adaptation to network inactivity and identify RIM, synaptotagmin1, Ca(v)2.1, and SV2B as molecular candidates underlying the main silencing-induced functional hallmark at presynapse, i.e., increase of neurotransmitter release probability.

  15. Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    PubMed Central

    Kohansal-Nodehi, Mahdokht; Chua, John JE; Urlaub, Henning; Jahn, Reinhard; Czernik, Dominika

    2016-01-01

    Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles. While many of the proteins governing these processes are known, their regulation is only beginning to be understood. Here we have applied quantitative phosphoproteomics to identify changes in phosphorylation status of presynaptic proteins in resting and stimulated nerve terminals isolated from the brains of Wistar rats. Using rigorous quantification, we identified 252 phosphosites that are either up- or downregulated upon triggering calcium-dependent exocytosis. Particularly pronounced were regulated changes of phosphosites within protein constituents of the presynaptic active zone, including bassoon, piccolo, and RIM1. Additionally, we have mapped kinases and phosphatases that are activated upon stimulation. Overall, our study provides a snapshot of phosphorylation changes associated with presynaptic activity and provides a foundation for further functional analysis of key phosphosites involved in presynaptic plasticity. DOI: http://dx.doi.org/10.7554/eLife.14530.001 PMID:27115346

  16. Extensive ice stream activity on the North-East Greenland Continental Shelf

    NASA Astrophysics Data System (ADS)

    Arndt, Jan Erik; Jokat, Wilfried; Dorschel, Boris

    2015-04-01

    Even though approximately 20% of the modern day Greenland ice sheet is drained via the North-East Greenland Continental Shelf (NEGCS), its submarine geomorphology is only poorly resolved. Acting as the main export region for Arctic sea-ice transported southward by the cold East Greenland Current, the NEGCS shows year-round harsh ice conditions that limit the accessibility for research vessels to conduct swath bathymetric surveys. While studies based on radiocarbon dating were arguing if the ice sheet reached on the shelf during full-glacial periods, two studies using high-resolution swath bathymetric data from single cruise tracks showed submarine glacial seafloor features, including mega-scale glacial lineations and retreat moraines that gave direct marine evidence of past ice stream activity at least to the middle shelf in Westwind Trough. We have newly processed swath bathymetry and sub-bottom profiler data of 18 cruises of RV Polarstern from 1985 until 2014. This data was investigated for submarine glacial seafloor features to better constrain the past ice sheet configuration, including its maximum extent and retreat history. Amongst others, we have now first marine evidence for ice stream activity in Norske Trough and in general a more intense ice streaming activity on the shelf. In addition, our data indicates that possibly a small separate ice sheet was present offshore the modern day Greenland coast.

  17. Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis

    PubMed Central

    Thomas, Anna C.; Zeng, Zhiqiang; Rivière, Jean-Baptiste; O’Shaughnessy, Ryan; Al-Olabi, Lara; St.-Onge, Judith; Atherton, David J.; Aubert, Hélène; Bagazgoitia, Lorea; Barbarot, Sébastien; Bourrat, Emmanuelle; Chiaverini, Christine; Chong, W. Kling; Duffourd, Yannis; Glover, Mary; Groesser, Leopold; Hadj-Rabia, Smail; Hamm, Henning; Happle, Rudolf; Mushtaq, Imran; Lacour, Jean-Philippe; Waelchli, Regula; Wobser, Marion; Vabres, Pierre; Patton, E. Elizabeth; Kinsler, Veronica A.

    2016-01-01

    Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were detected at very low levels in affected tissues but were undetectable in the blood, indicating that these conditions are postzygotic mosaic disorders. In vitro expression of mutant GNA11R183C and GNA11Q209L in human cell lines demonstrated activation of the downstream p38 MAPK signaling pathway and the p38, JNK, and ERK pathways, respectively. Transgenic mosaic zebrafish models expressing mutant GNA11R183C under promoter mitfa developed extensive dermal melanocytosis recapitulating the human phenotype. Phakomatosis pigmentovascularis and extensive dermal melanocytosis are therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albright and Sturge-Weber syndromes. These findings will allow accurate clinical and molecular diagnosis of this subset of common birthmarks, thereby identifying infants at risk for serious complications, and provide novel therapeutic opportunities. PMID:26778290

  18. Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

    PubMed

    Thomas, Anna C; Zeng, Zhiqiang; Rivière, Jean-Baptiste; O'Shaughnessy, Ryan; Al-Olabi, Lara; St-Onge, Judith; Atherton, David J; Aubert, Hélène; Bagazgoitia, Lorea; Barbarot, Sébastien; Bourrat, Emmanuelle; Chiaverini, Christine; Chong, W Kling; Duffourd, Yannis; Glover, Mary; Groesser, Leopold; Hadj-Rabia, Smail; Hamm, Henning; Happle, Rudolf; Mushtaq, Imran; Lacour, Jean-Philippe; Waelchli, Regula; Wobser, Marion; Vabres, Pierre; Patton, E Elizabeth; Kinsler, Veronica A

    2016-04-01

    Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were detected at very low levels in affected tissues but were undetectable in the blood, indicating that these conditions are postzygotic mosaic disorders. In vitro expression of mutant GNA11(R183C) and GNA11(Q209L) in human cell lines demonstrated activation of the downstream p38 MAPK signaling pathway and the p38, JNK, and ERK pathways, respectively. Transgenic mosaic zebrafish models expressing mutant GNA11(R183C) under promoter mitfa developed extensive dermal melanocytosis recapitulating the human phenotype. Phakomatosis pigmentovascularis and extensive dermal melanocytosis are therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albright and Sturge-Weber syndromes. These findings will allow accurate clinical and molecular diagnosis of this subset of common birthmarks, thereby identifying infants at risk for serious complications, and provide novel therapeutic opportunities. PMID:26778290

  19. Extensive Reading in the EFL Classroom: Benefits of a Face-to-Face Collaboration Activity

    ERIC Educational Resources Information Center

    Kirchhoff, Cheryl

    2015-01-01

    Extensive reading is an approach to language education that has shown great promise for foreign language learners to acquire language; however, implementation reveals difficulty in maintaining student motivation to read over long periods of time. This study investigates students' experience of face-to-face talk about books in an extensive reading…

  20. 75 FR 21014 - Agency Information Collection Activities: Form I-694; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ...; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information..., Chief, Regulatory Products Division, Clearance Officer, 111 Massachusetts Avenue, NW., Washington, DC...: Extension of an existing information collection. (2) Title of the Form/Collection: Notice of Appeal...

  1. 77 FR 25722 - Agency Information Collection Activities: Form I-212; Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ...; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information... Collection (1) Type of Information Collection: Extension of an existing information collection. (2) Title of... filed by aliens requesting consent to reapply for admission to the United States after...

  2. 76 FR 34217 - Commission Information Collection Activities, Proposed Collections; Comment Request; Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... OMB approve these information collections with a three-year extension of the expiration dates, with no... below to the Office of Management and Budget (OMB) for review and an extension of the expiration date... structure, FERC requires that the applicant submit a notice of change within 30 days from the date of...

  3. Early active extension after anterior cruciate ligament reconstruction does not result in increased laxity of the knee.

    PubMed

    Isberg, Jonas; Faxén, Eva; Brandsson, Sveinbjörn; Eriksson, Bengt I; Kärrholm, Johan; Karlsson, Jon

    2006-11-01

    If permission of full active and passive extension immediately after an anterior cruciate ligament (ACL) reconstruction will increase the post-operative laxity of the knee has been a subject of discussion. We investigated whether a post-operative rehabilitation protocol including active and passive extension without any restrictions in extension immediately after an ACL reconstruction would increase the post-operative anterior-posterior knee laxity (A-P laxity). Our hypothesis was that full active and passive extension immediately after an ACL reconstruction would have no effect on the A-P laxity and clinical results up to 2 years after the operation. Twenty-two consecutive patients (14 men, 8 women, median age 21 years, range 17-41) were included. All the patients had a unilateral ACL rupture and no other ligament injuries or any other history of previous knee injuries. The surgical procedure was identical in all patients and one experienced surgeon operated on all the patients, using the bone-patellar tendon-bone autograft. The post-operative rehabilitation programme was identical in both groups, except for extension training during the first 4 weeks post-operatively. The patients were randomly allocated to post-operative rehabilitation programmes either allowing (Group A, n=11) or not allowing [Group B (30 to -10 degrees ), n=11] full active and passive extension immediately after the operation. They were evaluated pre-operatively and at 6 months and 2 years after the reconstruction. To evaluate the A-P knee laxity, radiostereometric analysis (RSA) and KT-1000 arthrometer (KT-1000) measurements were used, range of motion, Lysholm score, Tegner activity level, the International Knee Documentation Committee (IKDC) evaluation system and one-leg-hop test quotient were used. Pre-operatively, the RSA measurements revealed side-to-side differences in Group A of 8.6 mm (2.3-15.4), median (range) and in Group B of 7.2 mm (2.2-17.4) (n.s.). The corresponding KT-1000

  4. Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53*

    PubMed Central

    DeHart, Caroline J.; Chahal, Jasdave S.; Flint, S. J.; Perlman, David H.

    2014-01-01

    The p53 tumor suppressor protein accumulates to very high concentrations in normal human fibroblasts infected by adenovirus type 5 mutants that cannot direct assembly of the viral E1B 55-kDa protein-containing E3 ubiquitin ligase that targets p53 for degradation. Despite high concentrations of nuclear p53, the p53 transcriptional program is not induced in these infected cells. We exploited this system to examine select post-translational modifications (PTMs) present on a transcriptionally inert population of endogenous human p53, as well as on p53 activated in response to etoposide treatment of normal human fibroblasts. These forms of p53 were purified from whole cell lysates by means of immunoaffinity chromatography and SDS-PAGE, and peptides derived from them were subjected to nano-ultra-high-performance LC-MS and MS/MS analyses on a high-resolution accurate-mass MS platform (data available via ProteomeXchange, PXD000464). We identified an unexpectedly large number of PTMs, comprising phosphorylation of Ser and Thr residues, methylation of Arg residues, and acetylation, ubiquitinylation, and methylation of Lys residues—for example, some 150 previously undescribed modifications of p53 isolated from infected cells. These modifications were distributed across all functional domains of both forms of the endogenous human p53 protein, as well as those of an orthologous population of p53 isolated from COS-1 cells. Despite the differences in activity, including greater in vitro sequence-specific DNA binding activity exhibited by p53 isolated from etoposide-treated cells, few differences were observed in the location, nature, or relative frequencies of PTMs on the two populations of human p53. Indeed, the wealth of PTMs that we have identified is consistent with a far greater degree of complex, combinatorial regulation of p53 by PTM than previously anticipated. PMID:24056736

  5. 75 FR 47311 - Extension of Agency Information Collection Activity Under OMB Review: Aviation Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... OMB Review: Aviation Security Infrastructure Fee Records Retention AGENCY: Transportation Security... retention of certain information necessary for TSA to help set the Aviation Security Infrastructure Fee... Title: Aviation Security Infrastructure Fee Records Retention. Type of Request: Extension of a...

  6. Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling

    PubMed Central

    Guo, Na; Liu, Zuojia; Zhao, Wenjing; Wang, Erkang; Wang, Jin

    2016-01-01

    Pancreatic cancer has been found with abnormal expression or mutation in Ras proteins. Oncogenic Ras activation exploits their extensive signaling reach to affect multiple cellular processes, in which the mitogen-activated protein kinase (MAPK) signaling exerts important roles in tumorigenesis. Therapies targeted Ras are thus of major benefit for pancreatic cancer. Although small molecule APY606 has been successfully picked out by virtual drug screening based on Ras target receptor, its in-depth mechanism remains to be elucidated. We herein assessed the antitumor activity of APY606 against human pancreatic cancer Capan-1 and SW1990 cell lines and explored the effect of Ras-MAPK and apoptosis-related signaling pathway on the activity of APY606. APY606 treatment resulted in a dose- and time-dependent inhibition of cancer cell viability. Additionally, APY606 exhibited strong antitumor activity, as evidenced not only by reduction in tumor cell invasion, migration and mitochondrial membrane potential but also by alteration in several apoptotic indexes. Furthermore, APY606 treatment directly inhibited Ras-GTP and the downstream activation of MAPK, which resulted in the down-regulation of anti-apoptotic protein Bcl-2, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (Bax, cytosolic Cytochrome c and Caspase 3) and of cyclin-dependent kinase 2 and Cyclin A, E. These data suggest that impairing Ras-MAPK signaling is a novel mechanism of action for APY606 during therapeutic intervention in pancreatic cancer. PMID:27223122

  7. Comprehensive program and plan for federal energy education, extension, and information activities: Fiscal Year 1981. Fifth report to congress

    SciTech Connect

    Not Available

    1981-12-01

    The activities conducted solely in Fiscal Year (FY) 1981 in the areas of Federal energy education, extension service, and information dissemination are reported. The broad purpose of the FY 1981 activities addressed has been to inform governmental and private sectors about the methods and technologies to conserve energy and to utilize renewable energy sources. With the increase in awareness on the part of energy users and decisionmakers, as well as additional information sources available from the private sector, the emphasis of the various Federal energy information activities is being focused on reporting results of Federal programs. The course of activities related to conservation and renewable energy information has been one of consolidation, both in terms of programmatic substance and methods. The practical impetus has been the redirection of Federal progrms and related budgetary revisions for FY 1981 and FY 1982. Further, products conveying information on conservation and renewable energy technologies have been examined extensively, pursuant to the Administration's directive in April 1981 on elimination of wasteful spending on periodicals, audiovisuals and similar materials. Efforts in coordination of conservation and renewable energy information activities of the Department of Energy (DOE) as well as other Federal agencies have adjusted to timetables for review and redirection of programs initially planned for FY 1981. Mechanisms to coordinate existing Federal energy information activities employed in previous fiscal years were continued in FY 1981 to the extent applicable under current Administration policy and the above-noted circumstances of redirection. Coordinating actions requiring convening of groups were held in abeyance pending resolution of programmatic issues.

  8. NASA Common Research Model Test Envelope Extension With Active Sting Damping at NTF

    NASA Technical Reports Server (NTRS)

    Rivers, Melissa B.; Balakrishna, S.

    2014-01-01

    The NASA Common Research Model (CRM) high Reynolds number transonic wind tunnel testing program was established to generate an experimental database for applied Computational Fluid Dynamics (CFD) validation studies. During transonic wind tunnel tests, the CRM encounters large sting vibrations when the angle of attack approaches the second pitching moment break, which can sometimes become divergent. CRM transonic test data analysis suggests that sting divergent oscillations are related to negative net sting damping episodes associated with flow separation instability. The National Transonic Facility (NTF) has been addressing remedies to extend polar testing up to and beyond the second pitching moment break point of the test articles using an active piezoceramic damper system for both ambient and cryogenic temperatures. This paper reviews CRM test results to gain understanding of sting dynamics with a simple model describing the mechanics of a sting-model system and presents the performance of the damper under cryogenic conditions.

  9. Active site-directed plasmin inhibitors: Extension on the P2 residue.

    PubMed

    Hidaka, Koushi; Gohda, Keigo; Teno, Naoki; Wanaka, Keiko; Tsuda, Yuko

    2016-02-15

    Based on the structure of YO-2 [N-(trans-4-aminomethylcyclohexanecarbonyl)-l-Tyr(O-picolyl)-NH-octyl], active site-directed plasmin (Plm) inhibitors were explored. The picolyl moiety in the Tyr(O-picolyl) residue (namely, the P2 residue) was replaced with smaller or larger groups, such as hydrogen, tert-butyl, benzyl, (2-naphthyl)methyl, and (quinolin-2-yl)methyl. Those efforts produced compound 17 {N-(trans-4-aminomethylcyclohexanecarbonyl)-l-Tyr[O-(quinolin-2-yl)methyl]-NH-octyl} [IC50=0.22 and 77μM for Plm and urokinase (UK), respectively], which showed not only 2.4-fold greater Plm inhibition than YO-2, but also an improvement in selectivity (Plm/UK) by 35-fold. The docking experiments of the Plm-17 complexes disclosed that the amino group of the tranexamyl moiety interacted with the side-chain of Asp753 which formed S1 site.

  10. 76 FR 28058 - BOEMRE Information Collection Activity: 1010-0068, Unitization, Extension of a Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ...: 1010-0068, Unitization, Extension of a Collection; Comment Request AGENCY: Bureau of Ocean Energy... collection (1010-0068). SUMMARY: To comply with the Paperwork Reduction Act of 1995 (PRA), BOEMRE is inviting... Blundon, 381 Elden Street, MS-4024, Herndon, Virginia 20170-4817. Please reference ICR 1010-0068 in...

  11. 75 FR 42448 - Agency Information Collection Activities; Proposed Collection; Comment Request; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ...; Comment Request; Extension of Supplemental Form to the Financial Status Report for all AoA Title III... to the Supplemental Form to the Financial Status Report for all AoA Title III Grantees. DATES: Submit....gov/AoARoot/Grants/Reporting_Requirements/Formula_269.aspx . The Supplemental form to the...

  12. 75 FR 6391 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires employers to make and keep... with several other Federal agencies. Pursuant to section 709(d) of Title VII of the Civil Rights Act of... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension......

  13. 75 FR 6392 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... VII of the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires labor organizations to... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without change: Local Union Report (EEO-3). SUMMARY: In accordance with the Paperwork Reduction Act, the...

  14. 76 FR 3628 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires labor organizations to make... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without Change: Local Union Report (EEO-3). SUMMARY: In accordance with the Paperwork Reduction Act, the...

  15. 75 FR 18833 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... VII of the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires labor organizations to... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension without change: Local Union Report (EEO-3). SUMMARY: In accordance with the Paperwork Reduction Act, the...

  16. 75 FR 18833 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires employers to make and keep... with several other Federal agencies. Pursuant to section 709(d) of Title VII of the Civil Rights Act of... Employment Opportunity Commission. ACTION: Notice of information collection--Emergency extension......

  17. 75 FR 63179 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... VII of the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires labor organizations to... Employment Opportunity Commission. ACTION: Notice of Information Collection--Emergency Extension Without Change: Local Union Report (EEO-3). SUMMARY: In accordance with the Paperwork Reduction Act, the...

  18. 75 FR 40829 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... VII of the Civil Rights Act of 1964, as amended, 42 U.S.C. 2000e-8(c), requires labor organizations to... Employment Opportunity Commission. ACTION: Notice of information collection--emergency extension without change: Local Union Report (EEO-3). SUMMARY: In accordance with the Paperwork Reduction Act, the...

  19. 78 FR 58348 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ...; Extension of a Currently Approved Collection: Capital Punishment Report of Inmates Under Sentence of Death...: Capital Punishment Report of Inmates under Sentence of Death. (3) Agency form number, if any, and the... Inmates under Sentence of Death; NPS-8A Update Report of Inmate under Sentence of Death; NPS-8B Status...

  20. 76 FR 40386 - Agency Information Collection Activities: Form I-905, Extension of an Existing Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... FR 20362, allowing for a 60-day public comment period. USCIS received one comment after publishing..., Extension of an Existing Information Collection; Comment Request ACTION: 30-Day Notice of Information Collection Under Review: Form I- 905, Application for Authorization to Issue Certification for Health...

  1. 76 FR 20362 - Agency Information Collection Activities: Form I-905, Extension of a Currently Approved...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ..., Extension of a Currently Approved Information Collection; Comment Request Action: 60-Day Notice of... Health Care Workers; OMB Control No. 1615-0086. The Department of Homeland Security, U.S. Citizenship and... sixty days until June 13, 2011. During this 60 day period, USCIS will be evaluating whether to...

  2. 75 FR 57049 - Extension of Agency Information Collection Activity Under OMB Review: Office of Law Enforcement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... June 16, 2010, 75 FR 34148. The collection involves a certification form that applicants for the... Certification. Type of Request: Extension of a currently approved collection. OMB Control Number: 1652-0043..., neurosis, or any other personality or mental disorder that clearly demonstrates a potential hazard to...

  3. 77 FR 65701 - Extension of Agency Information Collection Activity Under OMB Review: Office of Law Enforcement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... July 20, 2012, 77 FR 42751. The collection involves a certification form that applicants for the... Certification. Type of Request: Extension of a currently approved collection. OMB Control Number: 1652-0043..., neurosis, or any other personality or mental disorder that clearly demonstrates a potential hazard to...

  4. 76 FR 70470 - Extension of Agency Information Collection Activity Under OMB Review: Law Enforcement Officer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ...) control number 1652-0034, abstracted below to OMB for review and approval of an extension of the currently... period soliciting comments, of the following collection of information on August 10, 2011, 76 FR 49504... required to respond to, a collection of information unless it displays a valid OMB control number. The...

  5. 75 FR 41214 - Agency Information Collection Activities: Extension of a Currently Approved Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... be requested via email to: forms.ice@dhs.gov with ``ICE Form G-146'' in the subject line. Dated: July... Information Collection for Review; Form G-146, Nonimmigrant Checkout Letter; OMB Control No. 1653-0020. The...: Extension of a currently approved Information Collection. (2) Title of the Form/Collection:...

  6. 77 FR 8278 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ...: Extension of a Currently Approved Collection; Victims of Crime Act, Crime Victim Assistance Grant Program... (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) will be submitting the... approved collection. (2) Title of the Form/Collection: Victims of Crime Act, Crime Victim Assistance...

  7. 77 FR 36009 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ...: Extension of a Currently Approved Collection; Victims of Crime Act, Crime Victim Assistance Grant Program... (OJP), Office for Victims of Crime (OVC) will be submitting the following information collection...Lano Foster 202-616-3612, Office for Victims of Crime, Office of Justice Programs, U.S. Department...

  8. 76 FR 77258 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ...: Extension of a Currently Approved Collection; Victim of Crime Act, Crime Victim Assistance Grant Program... (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) will be submitting the... information, please contact DeLano Foster (202) 616-3612, Office for Victims of Crime, Office of...

  9. 77 FR 50718 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ...: Extension of a Currently Approved Collection; Victims of Crime Act, Crime Victim Assistance Grant Program... Justice (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) will be submitting the... collection. (2) Title of the Form/Collection: Victims of Crime Act, Crime Victim Assistance Grant...

  10. 75 FR 18832 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ...In accordance with the Paperwork Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the Office of Management and Budget (OMB) a request for a 90-day emergency extension of the Elementary-Secondary Staff Information Report (EEO-5) to be effective after the current April 30, 2010 expiration...

  11. 75 FR 40828 - Agency Information Collection Activities: Existing Collection; Emergency Extension

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ...In accordance with the Paperwork Reduction Act, the Equal Employment Opportunity Commission (EEOC or Commission) announces that it submitted to the Office of Management and Budget (OMB) a request for a 90-day emergency extension of the Elementary-Secondary Staff Information Report (EEO-5) to be effective after the current July 31, 2010 expiration...

  12. 76 FR 35023 - Agency Information Collection Activities: Proposed Collection; Comments Requested; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Requested; Extension of a Currently Approved Collection With Changes; State Criminal Alien Assistance.../collection: State Criminal Alien Assistance Program. (3) The agency form number, if any, and the applicable...(b) as amended in 1996, BJA administers the State Criminal Alien Assistance Program (SCAAP) with...

  13. 76 FR 19791 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... demonstration to the DOL that the transaction: (1) Is substantially similar in all material respects to at least... additional information, see the related notice published in the Federal Register on November 10, 2010 (75 FR...; Extension of Employee Retirement Income Security Act Prohibited Transaction Class Exemption 96-62,...

  14. The Cooperative Extension System's Use of USDA's Online Food and Physical Activity Tracker-Supertracker

    ERIC Educational Resources Information Center

    Hongu, Nobuko; Martinez, Cathy L.; Billias, Natalia N.; Wyatt, Melissa A.; Turner, Rachel J.; Manore, Melinda M.

    2014-01-01

    Nutrition professionals within the Cooperative Extension system use the USDA's interactive online tool SuperTracker, which is designed to help individuals track diet and physical activity (PA) to apply healthy eating patterns and improve PA. An investigation of all 50 states' Extension websites and interviews of Extension educators…

  15. Extensive hydrothermal activity revealed by multi-tracer survey in the Wallis and Futuna region (SW Pacific)

    NASA Astrophysics Data System (ADS)

    Konn, C.; Fourré, E.; Jean-Baptiste, P.; Donval, J. P.; Guyader, V.; Birot, D.; Alix, A. S.; Gaillot, A.; Perez, F.; Dapoigny, A.; Pelleter, E.; Resing, J. A.; Charlou, J. L.; Fouquet, Y.

    2016-10-01

    The study area is close to the Wallis and Futuna Islands in the French EEZ. It exists on the western boundary of the fastest tectonic area in the world at the junction of the Lau and North-Fiji basins. At this place, the unstable back-arc accommodates the plate motion in three ways: (i) the north Fiji transform fault, (ii) numerous unstable spreading ridges, and (iii) large areas of recent volcanic activity. This instability creates bountiful opportunity for hydrothermal discharge to occur. Based on geochemical (CH4, TDM, 3He) and geophysical (nephelometry) tracer surveys: (1) no hydrothermal activity could be found on the Futuna Spreading Centre (FSC) which sets the western limit of hydrothermal activity; (2) four distinct hydrothermal active areas were identified: Kulo Lasi Caldera, Amanaki Volcano, Fatu Kapa and Tasi Tulo areas; (3) extensive and diverse hydrothermal manifestations were observed and especially a 2D distribution of the sources. At Kulo Lasi, our data and especially tracer ratios (CH4/3He 50×106 and CH4/TDM 4.5) reveal a transient CH4 input, with elevated levels of CH4 measured in 2010, that had vanished in 2011, most likely caused by an eruptive magmatic event. By contrast at Amanaki, vertical tracer profiles and tracer ratios point to typical seawater/basalt interactions. Fatu Kapa is characterised by a substantial spatial variability of the hydrothermal water column anomalies, most likely due to widespread focused and diffuse hydrothermal discharge in the area. In the Tasi Tulo zone, the hydrothermal signal is characterised by a total lack of turbidity, although other tracer anomalies are in the same range as in nearby Fatu Kapa. The background data set revealed the presence of a Mn and 3He chronic plume due to the extensive and cumulative venting over the entire area. To that respect, we believe that the joined domain composed of our active area and the nearby active area discovered in the East by Lupton et al. (2012) highly contribute to the

  16. Within- and between-session reliability of the maximal voluntary knee extension torque and activation.

    PubMed

    Park, Jihong; Hopkins, J Ty

    2013-01-01

    A ratio between the torque generated by maximal voluntary isometric contraction (MVIC) and exogenous electrical stimulus, central activation ratio (CAR), has been widely used to assess quadriceps function. To date, no data exist regarding between-session reliability of this measurement. Thirteen neurologically sound volunteers underwent three testing sessions (three trials per session) with 48 hours between-session. Subjects performed MVICs of the quadriceps with the knee locked at 90° flexion and the hip at 85°. Once the MVIC reached a plateau, an electrical stimulation from superimposed burst technique (SIB: 125 V with peak output current 450 mA) was manually delivered and transmitted directly to the quadriceps via stimulating electrodes. CAR was calculated by using the following equation: CAR = MVIC torque/MVIC + SIB torque. Intraclass correlation coefficients (ICC) were calculated within- (ICC((2,1))) and between-session (ICC((2,k))) for MVIC torques and CAR values. Our data show that quadriceps MVIC and CAR are very reliable both within- (ICC((2,1)) = 0.99 for MVIC; 0.94 for CAR) and between-measurement sessions (ICC((2,k)) = 0.92 for MVIC; 0.86 for CAR) in healthy young adults. For clinical research, more data of the patients with pathological conditions are required to ensure reproducibility of calculation of CAR.

  17. Evidence of parasexual activity in "asexual amoebae" Cochliopodium spp. (Amoebozoa): extensive cellular and nuclear fusion.

    PubMed

    Tekle, Yonas I; Anderson, O Roger; Lecky, Ariel F

    2014-09-01

    The majority of microbial eukaryotes have long been considered asexual, though new evidence indicates sex, or sexual-like (parasexual) behaviors that deviate from the usual union of two gametes, among other variant aspects. Over a dozen amoebozoans are implicated to have sexual stages. However, the exact mechanism by which sex occurs in these lineages remains elusive. This is mainly due to the diverse quality and cryptic nature of their life cycle. In this study we present evidence of some previously unreported aspects of the life cycle of an amoeba, Cochliopodium, that undergoes unusual intraspecific interactions using light microscopy and immunocytochemistry. Similar to other amoebozoans, Cochliopodium, is considered asexual with no published reports of sex or parasexuality. We also investigated environmental conditions that govern the observed intraspecific interactions. Both light microscopic and immunocytochemistry evidence demonstrates Cochliopodium undergoes cellular fusion (plasmogamy) and nuclear fusion (karyogamy). Large plasmodia eventually undergo karyogamy and contain large fused, polyploid, nuclei. These are observed to fragment, subsequently, by karyotomy (nuclear fission) and cytoplasmic fission to yield uninucleated amoebae. This process could lead to a non-meiotic, parasexual exchange of chromosomes in Cochliopodium. These findings strongly suggest that Cochliopodium is involved in parasexual activity and should no longer be considered strictly asexual.

  18. The C-terminal extension of PrhG impairs its activation of hrp expression and virulence in Ralstonia solanacearum.

    PubMed

    Zhang, Yong; Luo, Feng; Hikichi, Yasufumi; Kiba, Akinori; Yasuo, Igarashi; Ohnishi, Kouhei

    2015-04-01

    Ralstonia solanacearum is the second most destructive bacterial plant pathogens worldwide and HrpG is the master regulator of its pathogenicity. PrhG is a close paralogue of HrpG and both belong to OmpR/PhoB family of two-component response regulators. Despite a high similarity (72% global identity and 96% similarity in helix-loop-helix domain), they display distinct roles in pathogenicity. HrpG is necessary for the bacterial growth in planta and pathogenicity, while PrhG is dispensable for bacterial growth in planta and contributes little to pathogenicity. The main difference between HrpG and PrhG is the 50-amino-acid-long C-terminal extension in PrhG (amino-acid residues 230-283), which is absent in HrpG. When this extension is deleted, truncated PrhGs (under the control of its native promoter) allowed complete recovery of bacterial growth in planta and wild-type virulence of hrpG mutant. This novel finding demonstrates that the extension region in PrhG is responsible for the functional difference between HrpG and PrhG, which may block the binding of PrhG to target promoters and result in impaired activation of hrp expression by PrhG and reduced virulence of R. solanacearum.

  19. Active knee joint flexibility and sports activity.

    PubMed

    Hahn, T; Foldspang, A; Vestergaard, E; Ingemann-Hansen, T

    1999-04-01

    The aim of the study was to estimate active knee flexion and active knee extension in athletes and to investigate the potential association of each to different types of sports activity. Active knee extension and active knee flexion was measured in 339 athletes. Active knee extension was significantly higher in women than in men and significantly positively associated with weekly hours of swimming and weekly hours of competitive gymnastics. Active knee flexion was significantly positively associated with participation in basketball, and significantly negatively associated with age and weekly hours of soccer, European team handball and swimming. The results point to sport-specific adaptation of active knee flexion and active knee extension.

  20. Incipient extension along the active convergent margin of Nubia in Sicily, Italy: Cefalù-Etna seismic zone

    NASA Astrophysics Data System (ADS)

    Billi, Andrea; Presti, Debora; Orecchio, Barbara; Faccenna, Claudio; Neri, Giancarlo

    2010-08-01

    Recent geodetic data are compatible with NNE-SSW tectonic extension at a rate of ˜5 mm/yr in Sicily, southern Italy, within a broader region of net active compression along the Nubian plate margin (northern Africa). The structures that accommodate such extensional regime and its cause are still unknown. From field structural surveys and seismological analyses, the geometry, kinematics, structural architecture, and seismic potential of an extensional seismic zone linking Cefalù and Mount Etna in central eastern Sicily are defined. The zone includes high-angle WNW striking normal and right-lateral strike-slip faults and subordinate north and NNE striking strike-slip faults either right or left lateral. The occurrence of small discontinuous faults and the absence of related depressions and sedimentary basins suggest that the extensional regime is still in an incipient stage. The ongoing seismic activity possibly reactivates preexisting faults. Instrumentally and historically recorded earthquakes are lower than about 6 in magnitude, and destructive events are historically unknown since at least 1300 A.D. This apparent upper bound of earthquake magnitudes is consistent with the maximum magnitude values estimated from the length of the longest mapped faults and sources of seismic swarms, which all together suggest a value between 6 and 6.5 as the maximum expected magnitude that can be proposed at the present stage of investigation for earthquakes in the study area. Lateral extension on preexisting faults and upwelling of melt mantle material beneath Mount Etna are considered viable processes to explain, at least in part, the active extensional tectonics along the Cefalù-Etna seismic zone. Strike-slip seismic faulting beneath Mount Etna may be part of a previously proposed diffuse transfer zone affecting northeastern Sicily and including the Tindari Fault.

  1. Quantifying thigh muscle co-activation during isometric knee extension contractions: within- and between-session reliability.

    PubMed

    Katsavelis, Dimitrios; Threlkeld, A Joseph

    2014-08-01

    Muscle co-activation around the knee is important during ambulation and balance. The wide range of methodological approaches for the quantification of co-activation index (CI) makes comparisons across studies and populations difficult. The present study determined within- and between-session reliability of different methodological approaches for the quantification of the CI of the knee extensor and flexor muscles during maximum voluntary isometric contractions (MVICs). Eight healthy volunteers participated in two repeated testing sessions. A series of knee extension MVICs of the dominant leg with concomitant torque and electromyographic (EMG) recordings were captured. CI was calculated utilizing different analytical approaches. Intraclass correlation coefficient (ICC) showed that within-session measures displayed higher reliability (ICC>0.861) and lower variability (Coefficient of variation; CV<21.8%) than between-session measures (ICC<0.645; CV>24.2%). A selection of a 500ms or larger window of RMS EMG activity around the PT delivered more reliable and less variable results than other approaches. Our findings suggest that the CI can provide a reliable measure for comparisons among conditions and is best utilized for within-session experimental designs.

  2. Range of motion and leg rotation affect electromyography activation levels of the superficial quadriceps muscles during leg extension.

    PubMed

    Signorile, Joseph F; Lew, Karen M; Stoutenberg, Mark; Pluchino, Alessandra; Lewis, John E; Gao, Jinrun

    2014-09-01

    Leg extension (LE) is commonly used to strengthen the quadriceps muscles during training and rehabilitation. This study examined the effects of limb position (POS) and range of motion (ROM) on quadriceps electromyography (EMG) during 8 repetitions (REP) of LE. Twenty-four participants performed 8 LE REP at their 8 repetition maximum with lower limbs medially rotated (TI), laterally rotated (TO), and neutral (NEU). Each REP EMG was averaged over the first, middle, and final 0.524 rad ROM. For vastus medialis oblique (VMO), a REP × ROM interaction was detected (p < 0.02). The middle 0.524 rad produced significantly higher EMG than the initial 0.524 rad for REP 6-8 and the final 0.524 rad produced higher EMG than the initial 0.524 rad for REP 1, 2, 3, 4, 6, and 8 (p ≤ 0.05). For rectus femoris (RF), EMG activity increased across REP with TO generating the greatest activity (p < 0.001). For vastus lateralis (VL), EMG increased across REP (p < 0.001) with NEU and TO EMG increasing linearly throughout ROM and TI activity greatest during the middle 0.524 rad. We conclude that to target the VMO, the optimal ROM is the final 1.047 rad regardless of POS, while maximum EMG for the RF is generated using TO regardless of ROM. In contrast, the VL is maximally activated using TI over the first 1.047 rad ROM or in NEU over the final 0.524 rad ROM.

  3. Long-term community dynamics of small landbirds with and without exposure to extensive disturbance from military training activities.

    PubMed

    Rivers, James W; Gipson, Philip S; Althoff, Donald P; Pontius, Jeffrey S

    2010-02-01

    Military training activities are known to impact individual species, yet our understanding of how such activities influence animal communities is limited. In this study, we used long-term data in a case study approach to examine the extent to which the local small landbird community differed between a site in northeast Kansas that experienced intensive disturbance from military training activities (Ft. Riley Military Installation) and a similar, nearby site that experienced minimal human disturbance (Konza Prairie Biological Station). In addition, we characterized how the regional pool of potential colonizers influenced local community dynamics using Breeding Bird Survey data. From 1991 to 2001, most species of small terrestrial landbirds (73%) recorded during breeding surveys were found at both sites and the mean annual richness at Ft. Riley (39.0 +/- 2.86 [SD]) was very similar to that of Konza Prairie (39.4 +/- 2.01). Richness was maintained at relatively constant levels despite compositional changes because colonizations compensated local extinctions at both sites. These dynamics were driven primarily by woodland species that exhibited stochastic losses and gains and were present at a low local and regional abundance. Our results suggest that military training activities may mimic natural disturbances for some species in this area because the small landbird community did not differ markedly between sites with and sites without extensive human disturbance. Although our results suggest that military training is not associated with large changes in the avian community, additional studies are needed to determine if this pattern is found in other ecological communities.

  4. Long-Term Community Dynamics of Small Landbirds with and Without Exposure to Extensive Disturbance from Military Training Activities

    NASA Astrophysics Data System (ADS)

    Rivers, James W.; Gipson, Philip S.; Althoff, Donald P.; Pontius, Jeffrey S.

    2010-02-01

    Military training activities are known to impact individual species, yet our understanding of how such activities influence animal communities is limited. In this study, we used long-term data in a case study approach to examine the extent to which the local small landbird community differed between a site in northeast Kansas that experienced intensive disturbance from military training activities (Ft. Riley Military Installation) and a similar, nearby site that experienced minimal human disturbance (Konza Prairie Biological Station). In addition, we characterized how the regional pool of potential colonizers influenced local community dynamics using Breeding Bird Survey data. From 1991 to 2001, most species of small terrestrial landbirds (73%) recorded during breeding surveys were found at both sites and the mean annual richness at Ft. Riley (39.0 ± 2.86 [SD]) was very similar to that of Konza Prairie (39.4 ± 2.01). Richness was maintained at relatively constant levels despite compositional changes because colonizations compensated local extinctions at both sites. These dynamics were driven primarily by woodland species that exhibited stochastic losses and gains and were present at a low local and regional abundance. Our results suggest that military training activities may mimic natural disturbances for some species in this area because the small landbird community did not differ markedly between sites with and sites without extensive human disturbance. Although our results suggest that military training is not associated with large changes in the avian community, additional studies are needed to determine if this pattern is found in other ecological communities.

  5. A Pilot Study of the Head Extension Swallowing Exercise: New Method for Strengthening Swallowing-Related Muscle Activity.

    PubMed

    Oh, Jong-Chi

    2016-10-01

    This pilot study examined the effect of a new head extension swallowing exercise (HESE) on submental muscle activity and tongue strength in healthy volunteers. Fifteen young adults (10 females and 5 males) were instructed to extend their head backwards as much as possible, and while watching the ceiling, swallowed their saliva every 10 s for a duration of 20 min. Twenty-four treatments were performed over 8 weeks. The outcome variables evaluated at baseline, 4 and 8 weeks of training, and 12-week follow-up included mean and peak submental muscle activation amplitudes during normal and effortful swallowing measured via surface electromyography, and anterior and posterior isometric tongue pressures were measured with the Iowa Oral Performance Instrument. Results indicated that the muscle activation amplitudes during effortful swallowing increased significantly at 4 and 8 weeks compared to baseline (p < 0.025). However, the increases in amplitudes during normal swallowing were minor (nonsignificant) after 8 weeks compared to baseline. The isometric pressures of the tongue tip and the posterior part of the oral tongue were significantly higher at 8 weeks compared to baseline (p < 0.025). Thus, the 8-week HESE protocol significantly improved suprahyoid muscle activity during effortful swallowing as well as the isometric tongue pressures. The HESE appears effective in exercising and strengthening the suprahyoid muscles and tongue muscles in healthy participants. Although encouraging, these results need to be replicated in clinical trials for testing the therapeutic effects of the HESE in older adults and patients with dysphagia who present with decreased hyolaryngeal elevation.

  6. Range of motion and leg rotation affect EMG activation levels of the superficial quadriceps muscles during leg extension.

    PubMed

    Signorile, Joseph F; Lew, Karen; Stoutenberg, Mark; Pluchino, Alessandra; Lewis, John E; Gao, Jinrun

    2014-06-30

    The leg extension (LE) is commonly used to strengthen the quadriceps muscles during training and rehabilitation. This study examined the effects of limb position (POS) and range of motion (ROM) on quadriceps electromyography (EMG) during 8 repetitions (REP) of LE. Twenty-four participants performed eight LE REP at their 8-repetition maximum with lower limbs medially rotated (TI), laterally rotated (TO), and neutral (NEU). Each REP EMG was averaged over the first, middle, and final 0.524 rad ROM. For vastus medialis oblique (VMO), a REP x ROM interaction was detected (p<0.02). The middle 0.524 rad produced significantly higher EMG than the initial 0.524 rad for REP 6-8 and the final 0.524 rad produced higher EMG than the initial 0.524 rad for REP 1, 2, 3, 4, 6, 8 (p<0.05). For rectus femoris (RF), EMG activity increased across REP with TO generating the greatest activity (p<0.001). For vastus lateralis (VL), EMG increased across REP (p<0.001) with NEU and TO EMG increasing linearly throughout ROM, and TI activity greatest during the middle 0.524 rad. We conclude that to target the VMO the optimal ROM is the final 1.047 rad regardless of POS, while maximum EMG for the RF is generated using TO regardless of ROM. In contrast, the VL is maximally activated using TI over the first 1.047 rad ROM or in NEU over the final 0.524 rad ROM.

  7. Initiation of Extension in South China Continental Margin during the Active-Passive Margin Transition: Thermochronological and Kinematic Constraints

    NASA Astrophysics Data System (ADS)

    Zuo, X.; Chan, L. S.

    2015-12-01

    The South China continental margin is characterized by a widespread magmatic belt, prominent NE-striking faults and numerous rifted basins filled by Cretaceous-Eocene sediments. The geology denotes a transition from active to passive margin, which led to rapid modifications of crustal stress configuration and reactivation of older faults in this area. Our zircon fission-track data in this region show two episodes of exhumation: The first episode, occurring during 170-120Ma, affected local parts of the Nanling Range. The second episode, a more regional exhumation event, occurred during 115-70Ma, including the Yunkai Terrane and the Nanling Range. Numerical geodynamic modeling was conducted to simulate the subduction between the paleo-Pacific plate and the South China Block. The modeling results could explain the fact that exhumation of the granite-dominant Nanling Range occurred earlier than that of the gneiss-dominant Yunkai Terrane. In addition to the difference in rock types, the heat from Jurassic-Early Cretaceous magmatism in Nanling may have softened the upper crust, causing the area to exhume more readily than Yunkai. Numerical modeling results also indicate that (1) high lithospheric geothermal gradient, high slab dip angle and low convergence velocity favor the reversal of crustal stress state from compression to extension in the upper continental plate; (2) late Mesozoic magmatism in South China was probably caused by a slab roll-back; and (3) crustal extension could have occurred prior to the cessation of plate subduction. The inversion of stress regime in the continental crust from compression to crustal extension imply that the Late Cretaceous-early Paleogene red-bed basins in South China could have formed during the late stage of the subduction, accounting for the occurrence of volcanic events in some sedimentary basins. We propose that the rifting started as early as Late Cretaceous, probably before the cessation of subduction process.

  8. Extension of in vivo half-life of biologically active peptides via chemical conjugation to XTEN protein polymer.

    PubMed

    Podust, Vladimir N; Sim, Bee-Cheng; Kothari, Dharti; Henthorn, Lana; Gu, Chen; Wang, Chia-wei; McLaughlin, Bryant; Schellenberger, Volker

    2013-11-01

    XTEN, unstructured biodegradable proteins, have been used to extend the in vivo half-life of genetically fused therapeutic proteins and peptides. To expand the applications of XTEN technology to half-life extension of other classes of molecules, XTEN protein polymers and methods for chemical XTENylation were developed. Two XTEN precursors were engineered to contain enzymatically removable purification tags. The proteins were readily expressed in bacteria and purified to homogeneity by chromatography techniques. As proof-of-principle, GLP2-2G peptide was chemically conjugated to each of the two XTEN protein polymers using maleimide-thiol chemistry. The monodisperse nature of XTEN protein polymer enabled reaction monitoring as well as the detection of peptide modifications in the conjugated state using reverse phase-high performance liquid chromatography (RP-HPLC) and electrospray ionization mass spectrometry. The resulting GLP2-2G-XTEN conjugates were purified by preparative RP-HPLC to homogeneity. In comparison with recombinantly fused GLP2-2G-XTEN, chemically conjugated GLP2-2G-XTEN molecules exhibited comparable in vitro activity, in vitro plasma stability and pharmacokinetics in rats. These data suggest that chemical XTENylation could effectively extend the half-life of a wide spectrum of biologically active molecules, therefore broadening its applicability.

  9. Individuals with chronic low back pain demonstrate delayed onset of the back muscle activity during prone hip extension.

    PubMed

    Suehiro, Tadanobu; Mizutani, Masatoshi; Ishida, Hiroshi; Kobara, Kenichi; Osaka, Hiroshi; Watanabe, Susumu

    2015-08-01

    Prone hip extension (PHE) is commonly used in the evaluation of the stability of the lumbopelvic region. There is little evidence of difference in muscle activity onset timing between healthy individuals and individuals with chronic low back pain (CLBP) during PHE. The purpose of this study was to determine if individuals with and without CLBP differ in the onset time of the trunk and hip extensor muscles activity during PHE. The participants were 20 patients with CLBP and 20 healthy individuals. Electromyography data of the erector spinae, multifidus, gluteus maximus, and semitendinosus were collected during PHE using a surface electromyograph. Relative differences in the onset times between each muscle and the prime mover (i.e., the semitendinosus) were calculated. The onsets of the bilateral multifidus and contralateral erector spinae were significantly delayed in the CLBP group compared with the healthy group (p<0.001), despite the onset timings of leg movement not being significantly different between the groups. The onset times of the gluteus maximus and ipsilateral erector spinae showed no significant differences between the groups. These results suggest that individuals with CLBP use an altered, and possibly inadequate, trunk muscle recruitment pattern. PMID:25983204

  10. PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation.

    PubMed

    Lee, Hyeyoon; Lee, Seung Joon; Kim, Gun-Hwa; Yeo, Inchul; Han, Jin-Kwan

    2016-03-01

    Phospholipase D (PLD) is involved in the regulation of receptor-associated signaling, cell movement, cell adhesion and endocytosis. However, its physiological role in vertebrate development remains poorly understood. In this study, we show that PLD1 is required for the convergent extension (CE) movements during Xenopus gastrulation by activating Wnt/PCP signaling. Xenopus PLD1 protein is specifically enriched in the dorsal region of Xenopus gastrula embryo and loss or gain-of-function of PLD1 induce defects in gastrulation and CE movements. These defective phenotypes are due to impaired regulation of Wnt/PCP signaling pathway. Biochemical and imaging analysis using Xenopus tissues reveal that PLD1 is required for Fz7 receptor endocytosis upon Wnt11 stimulation. Moreover, we show that Fz7 endocytosis depends on dynamin and regulation of GAP activity of dynamin by PLD1 via its PX domain is crucial for this process. Taken together, our results suggest that PLD1 acts as a new positive mediator of Wnt/PCP signaling by promoting Wnt11-induced Fz7 endocytosis for precise regulation of Xenopus CE movements.

  11. Active-charging based powertrain control in series hybrid electric vehicles for efficiency improvement and battery lifetime extension

    NASA Astrophysics Data System (ADS)

    Zhang, Xi; Mi, Chris Chunting; Yin, Chengliang

    2014-01-01

    This paper presents a powertrain control strategy for a series hybrid electric vehicle (SHEV) based on the integrated design of an active charging scenario and fixed-boundary-layer sliding mode controllers (FBLSMCs). An optimized charging curve for the battery is predetermined rather than subject to engine output and vehicle power demand, which is a total inverse of normal SHEV powertrain control process. This is aimed to remove surge and high-frequency charge current, keep the battery staying in a high state-of-charge (SOC) region and avoid persistently-high charge power, which are positive factors to battery lifetime extension. Then two robust chattering-free FBLSMCs are designed to locate the engine operation in the optimal efficiency area. One is in charge of engine speed control, and the other is for engine/generator torque control. Consequently, not only fuel economy is improved but also battery life expectancy could be extended. Finally, simulation and experimental results confirm the validity and application feasibility of the proposed strategy.

  12. Acute changes in muscle activation and leg extension performance after different running exercises in elite long distance runners.

    PubMed

    Vuorimaa, Timo; Virlander, Rami; Kurkilahti, Pasi; Vasankari, Tommi; Häkkinen, Keijo

    2006-02-01

    This study investigated acute changes in muscle activation and muscular power performance after three different running exercises in elite long-distance runners. Twenty-two nationally and internationally ranked long-distance runners performed first an incremental treadmill running test until exhaustion (MR) and then 40 min continuous (TR) and intermittent (2 min run/2 min rest) (IR) running exercises at an intensity of 80 and 100% of the velocity associated with VO(2max), respectively. Muscle activation and muscular power performance tests (counter-movement jumps, CMJ, and a set of ten maximal half squats from the static starting position with an extra load of 35% of the subjects, one repetition maximum) were performed before and immediately after the runs. The average mechanical power (P) of the half squats was calculated and the root mean square electromyogram (EMGrms) from the vastus lateralis, vastus medialis, gastrocnemius and biceps femoris muscles was recorded simultaneously during the half squat performances. The results showed an acute exercise-induced increase in P (ANOVA time effect, P = 0.000) together with a reduction in EMGrms of the knee extensor muscles (ANOVA time effect, P = 0.000). However, mechanical P expressed as a relative change within the set decreased after MR. In TR the improvement in P correlated positively with the maximal running performance of the runners (P < 0.05), while in IR it correlated negatively (P < 0.05). Jumping performance was significantly enhanced after each run (P < 0.001, for all) and the improvement correlated negatively with the maximal sprinting speed and maximal jumping height of the runners (P < 0.01, for all). It is concluded that in elite long distance runners an intensive prolonged running exercise reduces the surface EMG of the knee extensor muscles, and may lead to a different coordination strategy in leg extension exercises performed into the vertical direction. After continuous type of running the power

  13. Is the Modified Tardieu Scale in Semi-Standing Position Better Associated with Knee Extension and Hamstring Activity in Terminal Swing than the Supine Tardieu?

    ERIC Educational Resources Information Center

    Faber, Irene R.; Nienhuis, Bart; Rijs, Nique P. A. M.; Geurts, Alexander C. H.; Duysens, Jacques

    2008-01-01

    The aim of this study was to investigate whether the modified Tardieu scale (MTS) in a semi-standing position, used for the assessment of hamstrings spasticity, was better associated with knee extension and hamstrings activity in terminal swing than the MTS in a supine position in children with cerebral palsy (CP). Seven children diagnosed with…

  14. 76 FR 24910 - Agency Information Collection Activities: Forms G-325, G-325A, G-325B, and G-325C; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... FR 6629, allowing for a 60-day public comment period. USCIS did not receive any comments for this... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-325, G-325A, G- 325B, and G-325C; Extension of a Currently Approved Information Collection; Comment...

  15. 76 FR 6629 - Agency Information Collection Activities: Forms G-325, G-325A, G-325B, and G-325C; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-325, G-325A, G- 325B, and G-325C; Extension of an Existing Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review; Forms 325, G-325A, G-325B, and G-325C,...

  16. Extension of the Optical Absorption Range in Zn-Doped MgO Powders and Its Effect on Antibacterial Activity

    NASA Astrophysics Data System (ADS)

    Ohira, Toshiaki; Kawamura, Mari; Fukuda, Masayuki; Alvarez, Kelly; Özkal, Burak; Yamamoto, Osamu

    2010-04-01

    In order to produce powder samples of Zn-doped MgO, the precursors, MgO and ZnO, were mixed in a molar ratio higher than 1.86 and subsequently treated at 1200 °C for 5 h in air atmosphere. With increasing Zn content in MgO, the lattice constant increased linearly, and the optical absorption intensity increased in the wavelength ranging from 200 to 400 nm. Antibacterial activity of the obtained powder samples was examined by colony count method using Escherichia coli and Staphylococcus aureus. In the antibacterial tests, it was found that the antibacterial activity enhanced with increasing Zn content in MgO. Antibacterial action toward S. aureus was greater than that toward E. coli, irrespective of the Zn content in MgO. From these results, the enhancement of the antibacterial activity could be related with the optical absorption of Zn-doped MgO.

  17. Muscle activation pattern and onset times during a semi-orthostatic, unilateral closed-kinetic hip extension exercise in adolescent males.

    PubMed

    Cochrane, Darryl J; Harnett, Michael C

    2015-07-01

    The hip extensors are an important muscle group for sporting and functional movements, but assessing this muscle group for musculoskeletal dysfunction and strength testing has been performed in adult males and females as a prone, open-chain exercise, which provides little posture specificity for locomotive activities. Given the importance of closed-kinetic chain exercises for strength and rehabilitation requirements, there is an obvious need to assess hip extension but little is known about executing a closed-kinetic chain hip extension exercise for adolescents. Therefore, the aim of this study was to ascertain hip extensor muscle activation pattern and force production using a semi-orthostatic position while performing a unilateral closed-kinetic hip extension exercise. Fourteen young healthy adolescent male participants performed three maximal repetitions of closed-kinetic chain left and right hip extension on a glute machine. Electromyography (EMG) from left and right rectus femoris (RF), gluteus maximus (GM), and biceps femoris (BF) was recorded and RF, GM, and BF EMG mean amplitude, EMG area and onset times were analysed. There was no significant difference in EMG mean amplitude and EMG area between RF, GM, and BF but the right hip showed a significantly higher EMG (p < 0.05) than the left hip. The relative onset difference between GM and BF was similar in both hips, suggesting that there was no dominant muscle firing order. The closed-kinetic chain hip extension could be advantageous when assessing neuromuscular function and training muscle strength because the semi-orthostatic position of hip extension exercise provides a posture similar to functional activities. PMID:25613523

  18. Muscle activation pattern and onset times during a semi-orthostatic, unilateral closed-kinetic hip extension exercise in adolescent males.

    PubMed

    Cochrane, Darryl J; Harnett, Michael C

    2015-07-01

    The hip extensors are an important muscle group for sporting and functional movements, but assessing this muscle group for musculoskeletal dysfunction and strength testing has been performed in adult males and females as a prone, open-chain exercise, which provides little posture specificity for locomotive activities. Given the importance of closed-kinetic chain exercises for strength and rehabilitation requirements, there is an obvious need to assess hip extension but little is known about executing a closed-kinetic chain hip extension exercise for adolescents. Therefore, the aim of this study was to ascertain hip extensor muscle activation pattern and force production using a semi-orthostatic position while performing a unilateral closed-kinetic hip extension exercise. Fourteen young healthy adolescent male participants performed three maximal repetitions of closed-kinetic chain left and right hip extension on a glute machine. Electromyography (EMG) from left and right rectus femoris (RF), gluteus maximus (GM), and biceps femoris (BF) was recorded and RF, GM, and BF EMG mean amplitude, EMG area and onset times were analysed. There was no significant difference in EMG mean amplitude and EMG area between RF, GM, and BF but the right hip showed a significantly higher EMG (p < 0.05) than the left hip. The relative onset difference between GM and BF was similar in both hips, suggesting that there was no dominant muscle firing order. The closed-kinetic chain hip extension could be advantageous when assessing neuromuscular function and training muscle strength because the semi-orthostatic position of hip extension exercise provides a posture similar to functional activities.

  19. Inter-rater agreement, sensitivity, and specificity of the prone hip extension test and active straight leg raise test

    PubMed Central

    2014-01-01

    Background Two clinical tests used to assess for neuromuscular control deficits in low back pain (LBP) patients are the prone hip extension (PHE) test and active straight leg raise (ASLR) test. For these tests, it has been suggested examiners classify patients as “positive” or “negative” based on the presence or absence (respectively) of specific “abnormal” lumbopelvic motion patterns. The inter-rater agreement of such a classification scheme has been reported for the PHE test, but not for the ASLR test. In addition, the sensitivity and specificity of such classification schemes have not been reported for either test. The primary objectives of the current study were to investigate: 1) the inter-rater agreement of the examiner-reported classification schemes for these two tests, and 2) the sensitivity and specificity of the classification schemes. Methods Thirty participants with LBP and 40 asymptomatic controls took part in this cross-sectional observational study. Participants performed 3–4 repetitions of each test whilst two examiners classified them as “positive” or “negative” based on the presence or absence (respectively) of specific “abnormal” lumbopelvic motion patterns. The inter-rater agreement (Kappa statistic), sensitivity (LBP patients), and specificity (controls) were calculated for each test. Results Both tests demonstrated substantial inter-rater agreement (PHE test: Kappa = 0.76, 95% CI = 0.57-0.95, p < 0.001; ASLR test: Kappa = 0.76, 95% CI = 0.57-0.96, p < 0.001). For the PHE test, the sensitivity was 0.18-0.27 and the specificity was 0.63-0.78; the odds ratio (OR) of “positive” classifications in the LBP group was 1.25 (95% CI = 0.58-2.72; Examiner 1) and 1.27 (95% CI = 0.52-3.12; Examiner 2). For the ASLR test, the sensitivity was 0.20-0.25 and the specificity was 0.84-0.86; the OR of “positive” classifications in the LBP group was 1.72 (95% CI = 0.75-3.95; Examiner 1) and 1

  20. 76 FR 27077 - Agency Information Collection Activities: Form AR-11 and Form AR-11SR, Extension of an Existing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form AR-11 and...; OMB Control No. 1615-0007. The Department of Homeland Security, U.S. Citizenship and Immigration... collection: Form AR-11 and Form AR-11SR. U.S. Citizenship and Immigration Services. (4) Affected public...

  1. 77 FR 50521 - Agency Information Collection Activities: Under Section 245A of the INA, Form I-687; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... 77 FR 27471, allowing for a 60-day public comment period. USCIS did not receive any comments in... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Under Section...-Day Notice. SUMMARY: The Department of Homeland Security (DHS), U.S. Citizenship and...

  2. 77 FR 3486 - Agency Information Collection Activities: No Agency Form Number, File Number OMB 25, Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

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  3. 76 FR 31972 - Agency Information Collection Activities: Form I-508 and Form I-508F, Extension of a Currently...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-508 and... and Immigration Services (USCIS), will be submitting the following information collection request for... Immigration Services. (4) Affected public who will be asked or required to respond, as well as a...

  4. 75 FR 65021 - Agency Information Collection Activities: Form I-485 and Supplements A and E, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... Federal Register on June 30, 2010, at 75 FR 37820, allowing for a 60-day public comment period. USCIS did... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Form I-485 and... Security, U.S. Citizenship and Immigration Services (USCIS) will be submitting the following...

  5. Social Guardianship and Social Isolation: An Application and Extension of Lifestyle/Routine Activities Theory to Rural Adolescents

    ERIC Educational Resources Information Center

    Spano, Richard; Nagy, Steve

    2005-01-01

    Although the overall crime rate dropped between 1993 and 2000, both adolescent violence and violent crime in rural areas has been on the rise. However, little research has been conducted on the determinants of rural violence using targeted regional samples of rural youth. This study examines the applicability of lifestyle/routine activities (RA)…

  6. Magma-tectonic interactions in an area of active extension; a review of recent observations, models and interpretations from Iceland

    NASA Astrophysics Data System (ADS)

    Pedersen, Rikke; Sigmundsson, Freysteinn; Drouin, Vincent; Rafn Heimisson, Elías; Parks, Michelle; Dumont, Stéphanie; Árnadóttir, Þóra; Masterlark, Timothy; Ófeigsson, Benedíkt G.; Jónsdóttir, Kristín; Hooper, Andrew

    2016-04-01

    The geological setting of Iceland provides rich opportunities of studying magma-tectonic interactions, as it constitutes Earth's largest part of the mid-oceanic ridge system exposed above sea level. A series of volcanic and seismic zones accommodate the ~2 cm/year spreading between the North-American and Eurasian plates, and the Icelandic hot-spot conveniently provides the means of exposing this oceanic crust-forming setting above sea-level. Both extinct and active plumbing system structures can be studied in Iceland, as the deeply eroded tertiary areas provide views into the structures of extinct volcanic systems, and active processes can be inferred on in the many active volcanic systems. A variety of volcanic and tectonic processes cause the Icelandic crust to deform continuously, and the availability of contemporaneous measurements of crustal deformation and seismicity provide a powerful data set, when trying to obtain insight into the processes working at depth, such as magma migration through the uppermost lithosphere, magma induced host rock deformation and volcanic eruption locations and styles. The inferences geodetic and seismic datasets allow on the active plate spreading processes and subsurface magma movements in Iceland will be reviewed, in particular in relation to the Northern Volcanic Zone (NVZ). There the three phases of a rifting cycle (rifting, post-rifting, inter-rifting) have been observed. The NVZ is an extensional rift segment, bounded to the south by the Icelandic mantle plume, and to the north by the Tjörnes transform zone. The NVZ has typically been divided into five partly overlapping en-echelon fissure swarms, each with a central main volcanic production area. Most recently, additional insight into controlling factors during active rifting has been provided by the Bárðarbunga activity in 2014-2015 that included a major rifting event, the largest effusive eruption in Iceland since 1783, and a gradual caldera collapse. It is evident

  7. Extension of the stability of motions in a combustion chamber by non- linear active control based on hysteresis

    SciTech Connect

    Knoop, P.; Culick, F.E.C.; Zukoski, E.E.

    1996-07-01

    This report presents the first quantitative data establishing the details of hysteresis whose existence in dynamical behavior was reported by Sterling and Zukoski. The new idea was demonstrated that the presence of dynamical hysteresis provides opportunity for a novel strategy of active nonlinear control of unsteady motions in combustors. A figure shows the hysteresis exhibited for the amplitude of pressure oscillations as a function of equivalence ratio in a combustor having a recirculation zone, in this case a dump combustor.

  8. Active-R filter

    DOEpatents

    Soderstrand, Michael A.

    1976-01-01

    An operational amplifier-type active filter in which the only capacitor in the circuit is the compensating capacitance of the operational amplifiers, the various feedback and coupling elements being essentially solely resistive.

  9. Understanding physical activity intentions among French Canadians with type 2 diabetes: an extension of Ajzen's theory of planned behaviour

    PubMed Central

    Boudreau, François; Godin, Gaston

    2009-01-01

    Background Regular physical activity is considered a cornerstone for managing type 2 diabetes. However, in Canada, most individuals with type 2 diabetes do not meet national physical activity recommendations. When designing a theory-based intervention, one should first determine the key determinants of physical activity for this population. Unfortunately, there is a lack of information on this aspect among adults with type 2 diabetes. The purpose of this cross-sectional study is to fill this gap using an extended version of Ajzen's Theory of Planned Behavior (TPB) as reference. Methods A total of 501 individuals with type 2 diabetes residing in the Province of Quebec (Canada) completed the study. Questionnaires were sent and returned by mail. Results Multiple hierarchical regression analyses indicated that TPB variables explained 60% of the variance in intention. The addition of other psychosocial variables in the model added 7% of the explained variance. The final model included perceived behavioral control (β = .38, p < .0001), moral norm (β = .29, p < .0001), and attitude (β = .14, p < .01). Conclusion The findings suggest that interventions aimed at individuals with type 2 diabetes should ensure that people have the necessary resources to overcome potential obstacles to behavioral performance. Interventions should also favor the development of feelings of personal responsibility to exercise and promote the advantages of exercising for individuals with type 2 diabetes. PMID:19531261

  10. Thrombin Enhances NGF-Mediated Neurite Extension via Increased and Sustained Activation of p44/42 MAPK and p38 MAPK

    PubMed Central

    Mufti, Rania E.; Sarker, Krishna; Jin, Yan; Fu, Songbin; Rosales, Jesusa L.; Lee, Ki-Young

    2014-01-01

    Rapid neurite remodeling is fundamental to nervous system development and plasticity. It involves neurite extension that is regulated by NGF through PI3K/AKT, p44/42 MAPK and p38 MAPK. It also involves neurite retraction that is regulated by the serine protease, thrombin. However, the intracellular signaling pathway by which thrombin causes neurite retraction is unknown. Using the PC12 neuronal cell model, we demonstrate that thrombin utilizes the PI3K/AKT pathway for neurite retraction in NGF-differentiated cells. Interestingly, however, we found that thrombin enhances NGF-induced neurite extension in differentiating cells. This is achieved through increased and sustained activation of p44/42 MAPK and p38 MAPK. Thus, thrombin elicits opposing effects in differentiated and differentiating cells through activation of distinct signaling pathways: neurite retraction in differentiated cells via PI3K/AKT, and neurite extension in differentiating cells via p44/42 MAPK and p38 MAPK. These findings, which also point to a novel cooperative role between thrombin and NGF, have significant implications in the development of the nervous system and the disease processes that afflicts it as well as in the potential of combined thrombin and NGF therapy for impaired learning and memory, and spinal cord injury which all require neurite extension and remodeling. PMID:25061982

  11. Multiple episodes of hydrothermal activity and epithermal mineralization in the southwestern Nevada volcanic field and their relations to magmatic activity, volcanism and regional extension

    SciTech Connect

    Weiss, S.I.; Noble, D.C.; Jackson, M.C.

    1994-12-31

    Volcanic rocks of middle Miocene age and underlying pre-Mesozoic sedimentary rocks host widely distributed zones of hydrothermal alteration and epithermal precious metal, fluorite and mercury deposits within and peripheral to major volcanic and intrusive centers of the southwestern Nevada volcanic field (SWNVF) in southern Nevada, near the southwestern margin of the Great Basin of the western United States. Radiometric ages indicate that episodes of hydrothermal activity mainly coincided with and closely followed major magmatic pulses during the development of the field and together spanned more than 4.5 m.y. Rocks of the SWNVF consist largely of rhyolitic ash-flow sheets and intercalated silicic lava domes, flows and near-vent pyroclastic deposits erupted between 15.2 and 10 Ma from vent areas in the vicinity of the Timber Mountain calderas, and between about 9.5 and 7 Ma from the outlying Black Mountain and Stonewall Mountain centers. Three magmatic stages can be recognized: the main magmatic stage, Mountain magmatic stage (11.7 to 10.0 Ma), and the late magmatic stage (9.4 to 7.5 Ma).

  12. Quaternary migration of active extension revealed by a syn-tectonic alluvial fan shift. A case study in the Northern Apennines of Italy

    NASA Astrophysics Data System (ADS)

    Mirabella, Francesco; Bucci, Francesco; Cardinali, Mauro; Santangelo, Michele; Guzzetti, Fausto

    2016-04-01

    In areas characterized by the progressive migration of active extension through time, shifts in the position of the active depocenter occur. Such shifts through time produces peculiar geomorphological settings that are often characterized by wind gaps, abandoned valleys, streams captures and drainage inversions. These features provide the opportunity to investigate active areas by studying the recent-most geological history of the related nearby basins. We investigate this topic in a tectonically active area in the Northern Apennines of Italy, as indicated by both instrumental and historical seismicity (maximum epicentral intensity I0=VIII) and extension rates in the order of 2.5-2.7 mm/yr. In particular, we study the Montefalco ridge drainage inversion. Here, fluvial sands and imbricated conglomerates deposited in a lower Pleistocene depocenter constituted by an extensional subsiding basin, are presently uplifted more than 200 m above the present day alluvial plain. The Montefalco ridge drainage inversion, at about 400 m a.s.l., separates two valleys, the Gualdo Cattaneo - Bastardo valley to the West (300 m a.s.l.) and the Foligno present-day alluvial plain to the East (200 m a.s.l.). Seismic reflection data show that the maximum thickness of the continental sequence in the Foligno valley is in the order of 500 m. This valley is presently occupied by a 37 km2 alluvial fan produced by the Topino river flowing from NE to SW. To unravel the Quaternary tectonic evolution of the area, we integrate different data sets collected by field mapping, detailed photo-geological data, sediments provenance information, and subsurface data. We interpret the Montefalco ridge as a paleo-Foligno-like alluvial fan representing the evidence of the recent migration of the active extension to the East of around 7 km. Considering an age of deformation of 2.5 My, an extension rate of about 2.8 mm/yr is derived, which corresponds to the present-day geodetic rates. We stress the importance

  13. A study of tectonic activity in the Basin-Range Province and on the San Andreas Fault. No. 1: Kinematics of Basin-Range intraplate extension

    NASA Technical Reports Server (NTRS)

    Eddington, P. K.; Smith, R. B.; Renggli, C.

    1986-01-01

    Strain rates assessed from brittle fracture and total brittle-ductile deformation measured from geodetic data were compared to estimates of paleo-strain from Quaternary geology for the intraplate Great Basin part of the Basin-Range, western United States. These data provide an assessment of the kinematics and mode of lithospheric extension that the western U.S. Cordillera has experienced from the past few million years to the present. Strain and deformation rates were determined by the seismic moment tensor method using historic seismicity and fault plane solutions for sub-regions of homogeneous strain. Contemporary deformation in the Great Basin occurs principally along the active seismic zones. The integrated opening rate across the entire Great Basin is accommodated by E-E extension at 8 to 10 mm/a in the north that diminishes to NW-SE extension of 3.5 mm/a in the south. Zones of maximum lithospheric extension correspond to belts of thin crust, high heat flow, and Quaternary basaltic volcanism, suggesting that these parameters are related through mechanism of extension such as a stress relaxation, allowing bouyant uplift and ascension of magmas.

  14. Mapping lifecycle management activities for blockbuster drugs in Japan based on drug approvals and patent term extensions.

    PubMed

    Yamanaka, Takayuki; Kano, Shingo

    2016-02-01

    Drug lifecycle management (LCM), which entails acquiring drug approvals and patent protections, contributes to maximizing drug discovery investment returns. In a previous survey, a comparative analysis between Japan and the USA indicated that a unique patent term extension system has an important role in Japanese drug LCM. Therefore, in this survey, we focused on drug approvals and patent term extensions, and found that the LCM for blockbuster drugs in Japan can be categorized into three types (drug approval-oriented LCM, patent term extension-oriented LCM, and inactive-type LCM), of which the first two have been implemented recently. Here, we suggest a strategy for selecting a suitable LCM approach among these three types based on the prospects for drug improvements.

  15. 76 FR 23833 - Agency Information Collection Activities: Supplement A to Form I-539: Extension of an Existing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... Notice of Information Collection Under Review: Supplement A to Form I-539 (Filing Instructions for V... comments concerning the extension of Supplement A to Form I- 539 (Filing Instructions for V Nonimmigrant... V Nonimmigrant Status Applicants). (3) Agency form number, if any, and the applicable component...

  16. 75 FR 37820 - Agency Information Collection Activities: Form I-485 and Supplements A and E, Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... comments by e- mail please add the OMB Control Number 1615-0023 in the subject box. Written comments and... Supplements A and E, Extension of a Currently Approved Information Collection; Comment Request ACTION: 60-Day Notice of Information Collection Under Review: Form I- 485 and Supplements A and E, Application...

  17. 77 FR 9259 - Agency Information Collection Activities: Forms G-1041 and G-1041A, Extension of a Currently...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-16

    ... Notice of Information Collection Under Review: Forms G- 1041 and G-1041A, Genealogy Index Search Request...: Extension of an existing information collection. (2) Title of the Forms/Collections: Genealogy Index Search... and timely response to genealogy index search and records requests. (5) An estimate of the...

  18. Sugar beet activities of the USDA-ARS East Lansing conducted in cooperation with Saginaw Research & Extension Center during 2014

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evaluation and rating plots were planted at the Saginaw Valley Research & Extension Center (SVREC) in Frankenmuth, MI in 2014 that focused on Cercospora leaf spot (CLS) and Rhizoctonia crown and root rot (CRR) disease performance of a wide range of Beta vulgaris materials. CLS and CRR trials were co...

  19. Morphostructural evidence for Recent/active extension in Central Tanzania beyond the southern termination of the Kenya Rift.

    NASA Astrophysics Data System (ADS)

    Le Gall, B.; Rolet, J.; Gernigon, L.; Ebinger, C.; Gloaguen, R.

    2003-04-01

    The southern tip zone of the Kenya Rift on the eastern branch of the East African System is usually thought to occur in the so-called North Tanzanian Divergence. In this region, the narrow (50 km-wide) axial graben of southern Kenya splays southwards, via a major EW-trending volcanic lineament, into a 200 km-wide broad rifted zone with three separate arms of normal faulting and tilted fault blocks (Eyasi, Manyara and Pangani arms from W to E). Remote sensing analysis from Central Tanzania demonstrates that rift morphology exists over an area lying 400 km beyond the southern termination of the Kenya Rift. The most prominent rift structures are observed in the Kilombero region and consist of a 100 km-wide range of uplifted basement blocks fringed to the west by an E-facing half-graben inferred to reach depths of 6-8 km from aeromagnetic dataset. Physiographic features (fault scarps), and river drainage anomalies suggest that the present-day rift pattern in the Kilombero extensional province principally results from Recent/Neogene deformation. That assumption is also supported by the seismogenic character of a number of faults. The Kilombero half-graben is superimposed upon an earlier rift system, Karoo in age, which is totally overprinted and is only evidenced from its sedimentary infill. On the other hand, the nature and thickness of the inferred Neogene synrift section is still unknown. The Kilombero rifted zone is assumed to connect northwards into the central rift arm (Manyara) of the South Kenya Rift via a seismically active transverse fault zone that follows ductile fabrics within the Mozambican crystalline basement. The proposed rift model implies that incipient rifting propagates hroughout the cold and strong crust/lithosphere of Central Tanzania along Proterozoic (N140=B0E) basement weakness zones and earlier Karoo (NS)rift structures. A second belt of Recent-active linked fault/basins also extends further East from the Pangani rift arm to the offshore

  20. Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast.

    PubMed

    Kang, Woo Kyu; Kim, Yeong Hyeock; Kang, Hyun Ah; Kwon, Ki-Sun; Kim, Jeong-Yoon

    2015-09-02

    Silent information regulator 2 (Sir2), an NAD(+)-dependent protein deacetylase, has been proposed to be a longevity factor that plays important roles in dietary restriction (DR)-mediated lifespan extension. In this study, we show that the Sir2's role for DR-mediated lifespan extension depends on cAMP-PKA and casein kinase 2 (CK2) signaling in yeast. Sir2 partially represses the transcription of lifespan-associated genes, such as PMA1 (encoding an H(+)-ATPase) and many ribosomal protein genes, through deacetylation of Lys 16 of histone H4 in the promoter regions of these genes. This repression is relieved by Sir2 S473 phosphorylation, which is mediated by active cAMP-PKA and CK2 signaling. Moderate DR increases the replicative lifespan of wild-type yeast but has no effect on that of yeast expressing the Sir2-S473E or S473A allele, suggesting that the effect of Sir2 on DR-mediated lifespan extension is negatively regulated by S473 phosphorylation. Our results demonstrate a mechanism by which Sir2 contributes to lifespan extension.

  1. Comparison of different operational modes of a two-stage activated sludge pilot plant for the extension of the Vienna STP.

    PubMed

    Müller-Rechberger, H; Wandl, G; Winkler, S; Svardal, K; Matsché, N

    2001-01-01

    A pilot plant has been operated over a period of two years in order to investigate the performance and the operating characteristics of the plant concept developed for the extension of the main Vienna STP and to develop a simulation model which will be applied for operation support of the full stage plant. The pilot plant is a two stage activated sludge plant, each stage comprising of four aeration tanks and a clarifier tank. The pilot plant layout allows three different operational modes, each of which has been operated for several periods. The performance of the pilot plant during these periods is described and the different operational modes are compared to each other.

  2. Modeling external carbon addition in biological nutrient removal processes with an extension of the international water association activated sludge model.

    PubMed

    Swinarski, M; Makinia, J; Stensel, H D; Czerwionka, K; Drewnowski, J

    2012-08-01

    The aim of this study was to expand the International Water Association Activated Sludge Model No. 2d (ASM2d) to account for a newly defined readily biodegradable substrate that can be consumed by polyphosphate-accumulating organisms (PAOs) under anoxic and aerobic conditions, but not under anaerobic conditions. The model change was to add a new substrate component and process terms for its use by PAOs and other heterotrophic bacteria under anoxic and aerobic conditions. The Gdansk (Poland) wastewater treatment plant (WWTP), which has a modified University of Cape Town (MUCT) process for nutrient removal, provided field data and mixed liquor for batch tests for model evaluation. The original ASM2d was first calibrated under dynamic conditions with the results of batch tests with settled wastewater and mixed liquor, in which nitrate-uptake rates, phosphorus-release rates, and anoxic phosphorus uptake rates were followed. Model validation was conducted with data from a 96-hour measurement campaign in the full-scale WWTP. The results of similar batch tests with ethanol and fusel oil as the external carbon sources were used to adjust kinetic and stoichiometric coefficients in the expanded ASM2d. Both models were compared based on their predictions of the effect of adding supplemental carbon to the anoxic zone of an MUCT process. In comparison with the ASM2d, the new model better predicted the anoxic behaviors of carbonaceous oxygen demand, nitrate-nitrogen (NO3-N), and phosphorous (PO4-P) in batch experiments with ethanol and fusel oil. However, when simulating ethanol addition to the anoxic zone of a full-scale biological nutrient removal facility, both models predicted similar effluent NO3-N concentrations (6.6 to 6.9 g N/m3). For the particular application, effective enhanced biological phosphorus removal was predicted by both models with external carbon addition but, for the new model, the effluent PO4-P concentration was approximately one-half of that found from

  3. Extension of excitation functions up to 50 MeV for activation products in deuteron irradiations of Pr and Tm targets

    NASA Astrophysics Data System (ADS)

    Hermanne, A.; Tárkányi, F.; Takács, S.; Ditrói, F.

    2016-09-01

    Extension up to 50 MeV incident deuteron energy is presented for excitation functions of activation products formed in monoisotopic Tm (169Tm) and Pr (141Pr). By stacked foil irradiations direct and/or cumulative production of 140,139m,138Nd, 138mPr, 141,139,137m,135Ce on Pr and 166,169Yb, 166,167,168Tm on Tm targets were measured. Confirmation of earlier experimental results for all investigated radionuclides is found and the influence of the higher energy on thick target yields and batch production of medically relevant radionuclides (140Nd, 139Pr (as decay product of 139mNd), 166,169Yb, 167Tm) is discussed. A comparison of experimental values with TALYS1.6 code results (predicted values from TENDL-2015 on-line library) shows a better description of the (d,pxn) reactions than older ones.

  4. Growth maintenance of the maize primary root at low water potentials involves increases in cell-wall extension properties, expansin activity, and wall susceptibility to expansins.

    PubMed Central

    Wu, Y; Sharp, R E; Durachko, D M; Cosgrove, D J

    1996-01-01

    Previous work on the growth biophysics of maize (Zea mays L.) primary roots suggested that cell walls in the apical 5 mm of the elongation zone increased their yielding ability as an adaptive response to low turgor and water potential (psi w). To test this hypothesis more directly, we measured the acid-induced extension of isolated walls from roots grown at high (-0.03 MPa) or low (-1.6 MPa) psi w using an extensometer. Acid-induced extension was greatly increased in the apical 5 mm and was largely eliminated in the 5- to 10-mm region of roots grown at low psi w. This pattern is consistent with the maintenance of elongation toward the apex and the shortening of the elongation zone in these roots. Wall proteins extracted from the elongation zone possessed expansin activity, which increased substantially in roots grown at low psi w. Western blots likewise indicated higher expansin abundance in the roots at low psi w. Additionally, the susceptibility of walls to expansin action was higher in the apical 5 mm of roots at low psi w than in roots at high psi w. The basal region of the elongation zone (5-10 mm) did not extend in response to expansins, indicating that loss of susceptibility to expansins was associated with growth cessation in this region. Our results indicate that both the increase in expansin activity and the increase in cell-wall susceptibility to expansins play a role in enhancing cell-wall yielding and, therefore, in maintaining elongation in the apical region of maize primary roots at low psi w. PMID:11536740

  5. Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals

    PubMed Central

    Pickering, Suzanne; Hué, Stephane; Kim, Eun-Young; Reddy, Susheel; Wolinsky, Steven M.; Neil, Stuart J. D.

    2014-01-01

    The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires throughout infection in 14 individuals infected with HIV-1 clade B revealed extensive amino acid diversity of the Vpu protein. For the most part, this variation in Vpu increases over the course of infection and is associated with predicted epitopes of the individual's MHC class I haplotype, suggesting CD8+ T cell pressure is the major driver of Vpu sequence diversity within the host. Despite this variability, the Vpu functions of targeting CD4 and counteracting both physical virus restriction and NF-κB activation by tetherin are rigorously maintained throughout HIV-1 infection. Only a minority of circulating alleles bear lesions in either of these activities at any given time, suggesting functional Vpu mutants are heavily selected against even at later stages of infection. Comparison of Vpu proteins defective for one or several functions reveals novel determinants of CD4 downregulation, counteraction of tetherin restriction, and inhibition of NF-κB signalling. These data affirm the importance of Vpu functions for in vivo persistence of HIV-1 within infected individuals, not simply for transmission, and highlight its potential as a target for antiviral therapy. PMID:24465210

  6. Active turbulence in active nematics

    NASA Astrophysics Data System (ADS)

    Thampi, S. P.; Yeomans, J. M.

    2016-07-01

    Dense, active systems show active turbulence, a state characterised by flow fields that are chaotic, with continually changing velocity jets and swirls. Here we review our current understanding of active turbulence. The development is primarily based on the theory and simulations of active liquid crystals, but with accompanying summaries of related literature.

  7. Active tectonic extension across the Alto Tiberina normal fault system from GPS data modeling and InSAR velocity maps: new perspectives within TABOO Near Fault Observatory

    NASA Astrophysics Data System (ADS)

    Vadacca, Luigi; Anderlini, Letizia; Casarotti, Emanuele; Serpelloni, Enrico; Chiaraluce, Lauro; Polcari, Marco; Albano, Matteo; Stramondo, Salvatore

    2014-05-01

    The Alto Tiberina fault (ATF) is a low-angle (east-dipping at 15°) normal fault (LANF) 70 km long placed in the Umbria-Marche Apennines (central Italy), characterized by SW-NE oriented extension occurring at rates of 2-3 mm/yr. These rates were measured by continuous GPS stations belonging to several networks, which are denser in the study area thanks to additional sites recently installed in the framework of the INGV national RING network and of the ATF observatory. In this area historical and instrumental earthquakes mainly occur on west-dipping high-angle normal faults. Within this context the ATF has accumulated 2 km of displacement over the past 2 Ma, but at the same time the deformation processes active along this misoriented fault, as well as its mechanical behavior, are still unknown. We tackle this issue by solving for interseismic deformation models obtained by two different methods. At first, through the 2D and 3D finite element modeling, we define the effects of locking depth, synthetic and antithetic fault activity and lithology on the velocity gradient measured along the ATF system. Subsequently through a block modeling approach, we model the GPS velocities by considering the major fault systems as bounds of rotating blocks, while estimating the corresponding geodetic fault slip-rates and maps of heterogeneous fault coupling. Thanks to the latest imaging of the ATF deep structure obtained from seismic profiles, we improve the proposed models by modeling the fault as a complex rough surface to understand where the stress accumulations are located and the interseismic coupling changes. The preliminary results obtained show firstly that the observed extension is mainly accommodated by interseismic deformation on both the ATF and antithetic faults, highlighting the important role of this LANF inside an active tectonic contest. Secondarily, using the ATF surface "topography", we find an interesting correlation between microseismicty and creeping portions

  8. Activity of Colistin in Combination with Meropenem, Tigecycline, Fosfomycin, Fusidic Acid, Rifampin or Sulbactam against Extensively Drug-Resistant Acinetobacter baumannii in a Murine Thigh-Infection Model

    PubMed Central

    Wang, Xiumei; Cong, Yulong

    2016-01-01

    Few effective therapeutic options are available for treating severe infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). Using a murine thigh-infection model, we examined the in vivo efficacy of colistin in combination with meropenem, tigecycline, fosfomycin, fusidic acid, rifampin, or sulbactam against 12 XDR-AB strains. Colistin, tigecycline, rifampin, and sulbactam monotherapy significantly decreased bacterial counts in murine thigh infections compared with those observed in control mice receiving no treatment. Colistin was the most effective agent tested, displaying bactericidal activity against 91.7% of strains at 48 h post-treatment. With strains showing a relatively low minimum inhibitory concentration (MIC) for meropenem (MIC ≤ 32 mg/L), combination therapy with colistin plus meropenem caused synergistic inhibition at both 24 h and 48 h post-treatment. However, when the meropenem MIC was ≥64 mg/L, meropenem did not significantly alter the efficacy of colistin. The addition of rifampin and fusidic acid significantly improved the efficacy of colistin, showing a synergistic effect in 100% and 58.3% of strains after 24 h of treatment, respectively, while the addition of tigecycline, fosfomycin, or sulbactam did not show obvious synergistic activity. No clear differences in activities were observed between colistin-rifampin and colistin-fusidic acid combination therapy with most strains. Overall, our in vivo study showed that administering colistin in combination with rifampin or fusidic acid is more efficacious in treating XDR-AB infections than other combinations. The colistin-meropenem combination may be another appropriate option if the MIC is ≤32 mg/L. Further clinical studies are urgently needed to confirm the relevance of these findings. PMID:27315107

  9. Active Tectonics of the Umbria Region (Central Italy) in the Framework of the Neogene-Quaternary Extension of the Northern Apennines

    NASA Astrophysics Data System (ADS)

    Barchi, M. R.; Collettini, C.; Federico, C.; Minelli, G.; Mirabella, F.; Pauselli, C.

    2001-12-01

    geometry of this east-dipping, low angle (about 20° ) detachment has been reconstructed in great detail across an area of about 1500 km2, using a network of seismic reflection profiles, calibrated on deep wells and surface geology data. The fault displacement is of about 8 km. A surveying of the microseismicity, operated by a local network, shows that the earthquakes cluster along the fault trace, and are limited in the hangingwall of the fault. The major recent earthquakes, as well as most of the historical seismicity, are associated to a set of high angle, SW dipping normal faults, antithetic to the Altotiberina fault. The active faults of the Umbria region can be regarded as the present-day expression of the process of crustal extension of the western domain of the Northern Apennines, a process begun about 20 Ma in the Northern Tyrrhenian area, and regularly migrating since that time towards North-east, possibly driven by the roll back of the Adriatic crust, subducting westward into the upper mantle.

  10. Activity Scale.

    ERIC Educational Resources Information Center

    Kerpelman, Larry C.; Weiner, Michael J.

    This twenty-four item scale assesses students' actual and desired political-social activism in terms of physical participation, communication activities, and information-gathering activities. About ten minutes are required to complete the instrument. The scale is divided into two subscales. The first twelve items (ACT-A) question respondents on…

  11. Genome differentiation in a species pair of coregonine fishes: an extremely rapid speciation driven by stress-activated retrotransposons mediating extensive ribosomal DNA multiplications

    PubMed Central

    2013-01-01

    in both genomes, thus, leading to a rapid genome divergence. We attribute these extensive genome re-arrangements associated with speciation event to stress-induced retrotransposons (re)activation. Such causal interplay between genome differentiation, retrotransposons (re)activation and environmental conditions may become a topic to be explored in a broader genomic context in future evolutionary studies. PMID:23410024

  12. Proteasome Activators

    PubMed Central

    Stadtmueller, Beth M.; Hill, Christopher P.

    2011-01-01

    Summary Proteasomes degrade a multitude of protein substrates in the cytosol and nucleus, and thereby are essential for many aspects of cellular function. Because the proteolytic sites are sequestered in a closed barrel-shaped structure, activators are required to facilitate substrate access. Structural and biochemical studies of two activator families, 11S and Blm10, have provided insights to proteasome activation mechanisms, although the biological functions of these factors remain obscure. Recent advances have improved our understanding of the third activator family, including the 19S activator, which targets polyubiquitylated proteins for degradation. PMID:21211719

  13. Metamorphic Tectonites and Differential Exhumation Reveal 3D Nature of Extension and Lower Crustal Flow in the Active Woodlark Rift, Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Little, T. A.; Baldwin, S. L.; Fitzgerald, P. G.; Monteleone, B. D.; Peters, K. J.

    2004-12-01

    . Shear fabrics in MCCs closest to the Woodlark spreading ridges, including Normanby and Misima Islands are parallel to the NNE direction of 0.5-3.6 Ma Solomon Sea-Australia spreading. Farther west, lineations in the lower plates of the D'Entrecasteaux MCCs locally deflect ˜40-50° clockwise from this direction. This obliquity is interpreted to reflect inhomogeneous lower crustal extension to the west of the Woodlark spreading ridges. A rift corridor extending ˜100 km to the north of Goodenough and Fergusson Islands is defined by active normal faulting and subsidence of the Trobriand margin. We infer that a previously subducted, locally eclogite-bearing, slab of thinned Australian lower crust to the north of the islands is being pulled out from beneath this zone as it is being sinistrally sheared along its eastern edge. Today the rift zone steps ˜70 km south towards the Papuan Peninsula to define a right-step, an asymmetry that is enhanced by seafloor spreading east of ˜151.4° E. Published focal mechanisms suggest that N-S sinistral shear along the northern Woodlark rift is continuing. In central Normanby Island, ˜2 Ma andesites may have erupted along a transverse fault bounding the deeply exhumed D'Entrecasteaux corridor. Its offshore extension trends N along a major embayment in the Woodlark Rise.

  14. Active ratchets

    NASA Astrophysics Data System (ADS)

    Angelani, L.; Costanzo, A.; Di Leonardo, R.

    2011-12-01

    We analyze self-propelling organisms, or active particles, in a periodic asymmetric potential. Unlike standard ratchet effect for Brownian particles requiring external forcing, in the case of active particles asymmetric potential alone produces a net drift speed (active ratchet effect). By using theoretical models and numerical simulations we demonstrate the emergence of the rectification process in the presence of an asymmetric piecewise periodic potential. The broken spatial symmetry (external potential) and time symmetry (active particles) are sufficient ingredients to sustain unidirectional transport. Our findings open the way to new mechanisms to move in directional manner motile organisms by using external periodic static fields.

  15. Astronomy Activities.

    ERIC Educational Resources Information Center

    Greenstone, Sid

    This document consists of activities and references for teaching astronomy. The activities (which include objectives, list of materials needed, and procedures) focus on: observing the Big Dipper and locating the North Star; examining the Big Dipper's stars; making and using an astrolabe; examining retograde motion of Mars; measuring the Sun's…

  16. Faculty Activism

    ERIC Educational Resources Information Center

    Academe, 2005

    2005-01-01

    Blending scholarship and activism, whether domestic or international, takes some real work. Two scholar-activists reflect on why and how activism can be more than academic labor in this feature of the "Academe" journal. This feature includes the following brief reflections on political work, both local and global that demonstrates how on campus…

  17. Catalyst activator

    DOEpatents

    McAdon, Mark H.; Nickias, Peter N.; Marks, Tobin J.; Schwartz, David J.

    2001-01-01

    A catalyst activator particularly adapted for use in the activation of metal complexes of metals of Group 3-10 for polymerization of ethylenically unsaturated polymerizable monomers, especially olefins, comprising two Group 13 metal or metalloid atoms and a ligand structure including at least one bridging group connecting ligands on the two Group 13 metal or metalloid atoms.

  18. Outdoor Activities.

    ERIC Educational Resources Information Center

    Minneapolis Independent School District 275, Minn.

    Twenty-four activities suitable for outdoor use by elementary school children are outlined. Activities designed to make children aware of their environment include soil painting, burr collecting, insect and pond water collecting, studies of insect galls and field mice, succession studies, and a model of natural selection using dyed toothpicks. A…

  19. Early Jurassic Volcanism in the South Lhasa Terrane, Southern Tibet: Record of Back-arc Extension in the Active Continental Margin

    NASA Astrophysics Data System (ADS)

    Wei, Y.; Zhao, Z.; Zhu, D. C.; Wang, Z.; Liu, D.; Mo, X.

    2015-12-01

    Indus-Yarlung Zangbo Suture Zone (IYZSZ) represents the Mesozoic remnants of the Neo-Tethyan Ocean lithosphere after its northward subduction beneath the Lhasa Terrane. The evolution of the Neo-Tethyan Ocean prior to India-Asia collision remains unclear. To explore this period of history, we investigate zircon U-Pb geochronology, geochemistry and Nd-Hf isotopes of the Early Jurassic bimodal-like volcanic sequence around Dagze area, south Tibet. The volcanic sequence comprises calc-alkaline basalts to rhyolites whereas intermediate components are volumetrically restricted. Zircons from a basaltic andesite yielded crystallization age of 178Ma whereas those from 5 silicic rocks were dated at 183-174Ma, which suggest that both the basaltic and the silicic rocks are coeval. The basaltic rocks are enriched in LREE and LILE, and depleted in HFSE, with Epsilon Nd(t) of 1.6-4.0 and zircon Epsilon Hf(t) of 0.7-11.8, which implies that they were derived from a heterogenetic mantle source metasomatized by subduction components. Trace element geochemistry shows that the basaltic rocks are compositionally transitional from normal mid-ocean ridge basalts (N-MORB) to island arc basalts (IAB, e.g. Zedong arc basalts of ~160-155Ma in the south margin of Lhasa Terrane), with the signature of immature back-arc basin basalts. The silicic rocks display similar Nd-Hf isotopic features of the Gangdese batholith with Epsilon Nd(t) of 0.9-3.4 and zircon Epsilon Hf(t) of 2.4-17.7, indicating that they were possibly generated by anatexis of basaltic juvenile lower crust, instead of derived from the basaltic magma. These results support an Early to Middle Jurassic (183-155Ma) model that the back-arc extension tectonic setting were existing in the active continental margin in the south Lhasa Terrane.

  20. On the Use of the Passive and Active Voice in Astrophysics Journal Papers: With Extensions to Other Languages and Other Fields.

    ERIC Educational Resources Information Center

    Tarone, Elaine; Dwyer, Sharon; Gillette, Susan; Icke, Vincent.

    1998-01-01

    A study examined frequency of active, passive verb forms in two astrophysics journal articles, finding "we" plus an active voice occurs at least as frequently as the passive. This pattern typifies a previously unidentified type of research article, the logical argument scientific paper, whose characteristics are detailed. Similar pattern is seen…

  1. Activation analysis

    SciTech Connect

    Alfassi, Z.B. . Dept. of Nuclear Engineering)

    1990-01-01

    This volume contains 16 chapters on the application of activation analysis in the fields of life sciences, biological materials, coal and its effluents, environmental samples, archaeology, material science, and forensics. Each chapter is processed separately for the data base.

  2. Maintenance of Efficacy and Continuing Safety of Golimumab for Active Ulcerative Colitis: PURSUIT-SC Maintenance Study Extension Through 1 Year

    PubMed Central

    Gibson, Peter R; Feagan, Brian G; Sandborn, William J; Marano, Colleen; Strauss, Richard; Johanns, Jewel; Padgett, Lakshmi; Collins, Judith; Tarabar, Dino; Hebzda, Zbigniew; Rutgeerts, Paul; Reinisch, Walter

    2016-01-01

    Objectives: The safety and efficacy of subcutaneous golimumab through 2 years of maintenance therapy was evaluated in patients with moderate-to-severe ulcerative colitis (UC). Methods: Patients completing treatment through week 52 (placebo, golimumab 50, 100, every-4-weeks (q4w)) and evaluations at week 54 were eligible for this long-term extension (LTE) trial. Patients receiving placebo or golimumab 50 mg with worsening disease during the LTE could receive golimumab 100 mg. Efficacy assessments included the Mayo physician's global assessment (PGA) subscore, inflammatory bowel disease questionnaire (IBDQ), and corticosteroid use. Patients who were randomized to golimumab at PURSUIT-Maintenance baseline and continued receiving golimumab during the LTE were analyzed for efficacy (using intention-to-treat and “as observed” analyses; N=195) and safety (N=200). Patients treated with golimumab at any time from induction baseline through week 104 (N=1240) constituted the overall safety population. Results: Baseline demographics and disease characteristics of patients entering the LTE receiving golimumab were similar to those of all patients randomized to golimumab maintenance at baseline. At week 104, 80.5% (157/195) of patients had a PGA=0/1 (range weeks 56–104: 80.5–91.8%) and 56.4% (110/195) had a PGA=0 (weeks 56–104: range: 53.8–58.5%). Through week 104, 86% of patients maintained inactive or mild disease activity. Among 174 corticosteroid-free patients at week 54, 88.5% remained corticosteroid-free at week 104. At week 104, 62.2% (120/193) had an IBDQ score ≥170. Tuberculosis, opportunistic infection, and malignancy rates were low, and the overall safety profile was similar to that reported through week 54. Two non-melanoma skin cancers, one metastatic colon cancer, and two deaths (biventricular heart dysfunction, sepsis) occurred between weeks 54 and 104. Conclusion: Subcutaneous golimumab q4w through 2 years maintained clinical benefit and reduced

  3. Photocatalytic activity of PANI loaded coordination polymer composite materials: Photoresponse region extension and quantum yields enhancement via the loading of PANI nanofibers on surface of coordination polymer

    SciTech Connect

    Cui, Zhongping; Qi, Ji; Xu, Xinxin Liu, Lu; Wang, Yi

    2013-09-15

    To enhance photocatalytic property of coordination polymer in visible light region, polyaniline (PANI) loaded coordination polymer photocatalyst was synthesized through in-situ chemical oxidation of aniline on the surface of coordination polymer. The photocatalytic activity of PANI loaded coordination polymer composite material for degradation of Rhodamine B (RhB) was investigated. Compared with pure coordination polymer photocatalyst, which can decompose RhB merely under UV light irradiation, PANI loaded coordination polymer photocatalyst displays more excellent photocatalytic activity in visible light region. Furthermore, PANI loaded coordination polymer photocatalyst exhibits outstanding stability during the degradation of RhB. - Graphical abstract: PANI loaded coordination polymer composite material, which displays excellent photocatalytic activity under visible light was firstly synthesized through in-situ chemical oxidation of aniline on surface of coordination polymer. Display Omitted - Highlights: • This PANI loaded coordination polymer composite material represents the first conductive polymer loaded coordination polymer composite material. • PANI/coordination polymer composite material displays more excellent photocatalytic activity for the degradation of MO in visible light region. • The “combination” of coordination polymer and PANI will enable us to design high-activity, high-stability and visible light driven photocatalyst in the future.

  4. Integrin activation

    PubMed Central

    Ginsberg, Mark H.

    2014-01-01

    Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate. Conversely, cells can modulate the affinity of integrins for their ligands a process operationally defined as integrin activation. Analysis of activation of integrins has now provided a detailed molecular understanding of this unique form of “inside-out” signal transduction and revealed new paradigms of how transmembrane domains (TMD) can transmit long range allosteric changes in transmembrane proteins. Here, we will review how talin and mediates integrin activation and how the integrin TMD can transmit these inside out signals. [BMB Reports 2014; 47(12): 655-659] PMID:25388208

  5. Active Cytokinins

    PubMed Central

    Mornet, René; Theiler, Jane B.; Leonard, Nelson J.; Schmitz, Ruth Y.; Moore, F. Hardy; Skoog, Folke

    1979-01-01

    Four series of azidopurines have been synthesized and tested for cytokinin activity in the tobacco callus bioassay: 2- and 8-azido-N6-benzyladenines, -N6-(Δ2-isopentenyl)adenines, and -zeatins, and N6-(2- and 4-azidobenzyl)adenines. The compounds having 2-azido substitution on the adenine ring are as active as the corresponding parent compounds, while those with 8-azido substitution are about 10 or more times as active. The 8-azidozeatin, which is the most active cytokinin observed, exhibited higher than minimal detectable activity at 1.2 × 10−5 micromolar, the lowest concentration tested. The shape of the growth curve indicates that even a concentration as low as 5 × 10−6 micromolar would probably be effective. By comparison, the lowest active concentration ever reported for zeatin has been 5 × 10−5 micromolar, representing a sensitivity rarely attained. All of the azido compounds have been submitted to photolysis in aqueous ethanol, and the photoproducts have been detected and identified by low and high resolution mass spectrometry. They are rationalized as products of abstraction and insertion reactions of the intermediate nitrenes. The potential of the major released products as cytokinins was also assessed by bioassay. 2-Azido-N6-(Δ2-isopentenyl)adenine competed with [14C]kinetin for the cytokinin-binding protein isolated from wheat germ. When the azido compound was photolysed in the presence of this protein, its attachment effectively blocked the binding of [14C]kinetin. PMID:16661017

  6. Active microwaves

    NASA Technical Reports Server (NTRS)

    Evans, D.; Vidal-Madjar, D.

    1994-01-01

    Research on the use of active microwaves in remote sensing, presented during plenary and poster sessions, is summarized. The main highlights are: calibration techniques are well understood; innovative modeling approaches have been developed which increase active microwave applications (segmentation prior to model inversion, use of ERS-1 scatterometer, simulations); polarization angle and frequency diversity improves characterization of ice sheets, vegetation, and determination of soil moisture (X band sensor study); SAR (Synthetic Aperture Radar) interferometry potential is emerging; use of multiple sensors/extended spectral signatures is important (increase emphasis).

  7. Activity report

    SciTech Connect

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  8. Classroom Activities.

    ERIC Educational Resources Information Center

    Stuart, Frances R.

    This pamphlet suggests activities that may be used in the elementary school classroom. Chapter I lists various short plays that children can easily perform which encourage their imagination. Chapter II details a few quiet classroom games such as "I Saw,""Corral the Wild Horse,""Who Has Gone from the Room," and "Six-Man-Football Checkers." A number…

  9. Learning Activities.

    ERIC Educational Resources Information Center

    Tipton, Tom, Ed.

    1983-01-01

    Presents a flow chart for naming inorganic compounds. Although it is not necessary for students to memorize rules, preliminary skills needed before using the chart are outlined. Also presents an activity in which the mass of an imaginary atom is determined using lead shot, Petri dishes, and a platform balance. (JN)

  10. Leaf Activities.

    ERIC Educational Resources Information Center

    Mingie, Walter

    Leaf activities can provide a means of using basic concepts of outdoor education to learn in elementary level subject areas. Equipment needed includes leaves, a clipboard with paper, and a pencil. A bag of leaves may be brought into the classroom if weather conditions or time do not permit going outdoors. Each student should pick a leaf, examine…

  11. Get Active

    MedlinePlus

    ... Lifting small weights – you can even use bottled water or cans of food as weights Watch these videos for muscle strengthening exercises to do at home or at the gym. If you do muscle-strengthening activities with weights, check out the do’s and don’ ...

  12. Activated Sludge.

    ERIC Educational Resources Information Center

    Saunders, F. Michael

    1978-01-01

    Presents the 1978 literature review of wastewater treatment. This review covers: (1) activated sludge process; (2) process control; (3) oxygen uptake and transfer; (4) phosphorus removal; (5) nitrification; (6) industrial wastewater; and (7) aerobic digestion. A list of 136 references is also presented. (HM)

  13. 77 FR 50519 - Agency Information Collection Activities: Forms G-325, G-325A, G-325B, and G-325C; Extension of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ..., at 77 FR 35418, allowing for a 60-day public comment period. USCIS received a comment in connection... SECURITY U.S. Citizenship and Immigration Services Agency Information Collection Activities: Forms G-325, G..., Biographic Information. SUMMARY: The Department of Homeland Security (DHS), U.S. Citizenship and...

  14. Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine

    PubMed Central

    Aiyelaagbe, Olapeju O.; Hamid, Amao A.; Fattorusso, Ernesto; Taglialatela-Scafati, Orazio; Schröder, Heinz C.; Müller, Werner E. G.

    2011-01-01

    Extracts from Jatropha curcas, a plant used in African traditional medicine for various diseases, were tested for cytotoxic activity. The root extracts strongly reduced cell growth of tumor cells in vitro, a result consistent with the knowledge of the application of these plant extracts in traditional medicine, especially to cure/ameliorate cancer. A selection of pure diterpenoids existing in extracts from Jatropha species and isolated from J. curcas, for example, curcusone C, curcusone D, multidione, 15-epi-4Z-jatrogrossidentadion, 4Z-jatrogrossidentadion, 4E-jatrogrossidentadion, 2-hydroxyisojatrogrossidion, and 2-epi-hydroxyisojatrogrossidion, were likewise tested, and they also showed strong cytotoxic activity. It turned out that these extracts are highly active against L5178y mouse lymphoma cells and HeLa human cervix carcinoma cells, while they cause none or only very low activity against neuronal cell, for example, PC12. These data underscore that extracts from J. curcas or pure secondary metabolites from the plant are promising candidates to be anticancer drug, combined with low neuroactive effects. PMID:21754941

  15. Amino-terminal extension of 146 residues of L-type GATA-6 is required for transcriptional activation but not for self-association.

    PubMed

    Takada, Kayoko; Obayashi, Kanako; Ohashi, Kazuaki; Ohashi-Kobayashi, Ayako; Nakanishi-Matsui, Mayumi; Maeda, Masatomo

    2014-10-01

    Transcription factor GATA-6 plays essential roles in developmental processes and tissue specific functions through regulation of gene expression. GATA-6 mRNA utilizes two Met-codons in frame as translational initiation codons. Deletion of the nucleotide sequence encoding the PEST sequence (Glu(31)-Cys(46)) between the two initiation codons unusually reduced the protein molecular size on SDS-polyacrylamide gel-electrophoresis, and re-introduction of this sequence reversed this change. The long-type (L-type) GATA-6 containing this PEST sequence self-associated similarly to the short-type (S-type) GATA-6, as determined on co-immunoprecipitation of Myc-tagged GATA-6 with HA-tagged GATA-6. The L-type and S-type GATA-6 also interacted mutually. The L-type GATA-6 without the PEST sequence also self-associated and interacted with the S-type GATA-6. The transcriptional activation potential of L-type GATA-6 is higher than that of S-type GATA-6. When the PEST sequence (Glu(31)-Cys(46)) was inserted into the L-type GATA-6 without Arg(13)-Gly(101), the resultant recombinant protein showed significantly higher transcriptional activity, while the construct with an unrelated sequence exhibited lower activity. These results suggest that the Glu(31)-Cys(46) segment plays an important role in the transcriptional activation, although it does not participate in the self-association.

  16. Glucokinase activators.

    PubMed

    Filipski, Kevin J; Futatsugi, Kentaro; Pfefferkorn, Jeffrey A; Stevens, Benjamin D

    2012-07-01

    In this review we highlight recently disclosed progress in the field of small-molecule activators of the human glucokinase enzyme. Several of the reported chemotypes possess structural features that diverge from known leads; some of these modifications appear to be specifically designed to modulate tissue selectivity or discrete parameters of enzyme function (e.g., S0.5 v Vmax). This review will inform the reader of the extent of continued effort being directed toward discovery of a first-in-class drug for Type II diabetes mellitus that functions through this target. Patents were selected from those published in December 2009 up to November 2011; foreign filings were translated where possible to understand the claims and biological techniques utilized to characterize the reported glucokinase activators. Overall, there appears to be a recent trend leading to reduced patent filings for small-molecule glucokinase activators. There are many possible explanations for this trend; however, it is likely that the field has reached maturity and that the downturn of new disclosures represents the transition of many of these programs to the clinic.

  17. Active packaging with antifungal activities.

    PubMed

    Nguyen Van Long, N; Joly, Catherine; Dantigny, Philippe

    2016-03-01

    There have been many reviews concerned with antimicrobial food packaging, and with the use of antifungal compounds, but none provided an exhaustive picture of the applications of active packaging to control fungal spoilage. Very recently, many studies have been done in these fields, therefore it is timely to review this topic. This article examines the effects of essential oils, preservatives, natural products, chemical fungicides, nanoparticles coated to different films, and chitosan in vitro on the growth of moulds, but also in vivo on the mould free shelf-life of bread, cheese, and fresh fruits and vegetables. A short section is also dedicated to yeasts. All the applications are described from a microbiological point of view, and these were sorted depending on the name of the species. Methods and results obtained are discussed. Essential oils and preservatives were ranked by increased efficacy on mould growth. For all the tested molecules, Penicillium species were shown more sensitive than Aspergillus species. However, comparison between the results was difficult because it appeared that the efficiency of active packaging depended greatly on the environmental factors of food such as water activity, pH, temperature, NaCl concentration, the nature, the size, and the mode of application of the films, in addition to the fact that the amount of released antifungal compounds was not constant with time.

  18. Active packaging with antifungal activities.

    PubMed

    Nguyen Van Long, N; Joly, Catherine; Dantigny, Philippe

    2016-03-01

    There have been many reviews concerned with antimicrobial food packaging, and with the use of antifungal compounds, but none provided an exhaustive picture of the applications of active packaging to control fungal spoilage. Very recently, many studies have been done in these fields, therefore it is timely to review this topic. This article examines the effects of essential oils, preservatives, natural products, chemical fungicides, nanoparticles coated to different films, and chitosan in vitro on the growth of moulds, but also in vivo on the mould free shelf-life of bread, cheese, and fresh fruits and vegetables. A short section is also dedicated to yeasts. All the applications are described from a microbiological point of view, and these were sorted depending on the name of the species. Methods and results obtained are discussed. Essential oils and preservatives were ranked by increased efficacy on mould growth. For all the tested molecules, Penicillium species were shown more sensitive than Aspergillus species. However, comparison between the results was difficult because it appeared that the efficiency of active packaging depended greatly on the environmental factors of food such as water activity, pH, temperature, NaCl concentration, the nature, the size, and the mode of application of the films, in addition to the fact that the amount of released antifungal compounds was not constant with time. PMID:26803804

  19. Recommendations on the Nature and Level of U.S. Participation in the International Thermonuclear Experimental Reactor Extension of the Experimental Reactor Extension of the Engineering Design Activities. Panel Report To Fusion Energy Sciences Advisory Committee (FESAC)

    SciTech Connect

    none,

    1998-01-31

    The DOE Office of Energy Research chartered through the Fusion Energy Sciences Advisory Committee (FESAC) a panel to "address the topic of U. S. participation in an ITER construction phase, assuming the ITER Parties decide to proceed with construction." (Attachment 1: DOE Charge, September 1996). Given that there is expected to be a transition period of three to five years between the conclusion of the Engineering Design Activities (EDA) and the possible construction start, the DOE Office of Energy Research expanded the charge to "include the U.S. role in an interim period between the EDA and construction." (Attachment 2: DOE Expanded Charge, May 1997). This panel has heard presentations and received input from a wide cross-section of parties with an interest in the fusion program. The panel concluded it could best fulfill its responsibility under this charge by considering the fusion energy science and technology portion of the U.S. program in its entirety. Accordingly, the panel is making some recommendations for optimum use of the transition period considering the goals of the fusion program and budget pressures.

  20. Combined DTI Tractography and Functional MRI Study of the Language Connectome in Healthy Volunteers: Extensive Mapping of White Matter Fascicles and Cortical Activations.

    PubMed

    Vassal, François; Schneider, Fabien; Boutet, Claire; Jean, Betty; Sontheimer, Anna; Lemaire, Jean-Jacques

    2016-01-01

    Despite a better understanding of brain language organization into large-scale cortical networks, the underlying white matter (WM) connectivity is still not mastered. Here we combined diffusion tensor imaging (DTI) fiber tracking (FT) and language functional magnetic resonance imaging (fMRI) in twenty healthy subjects to gain new insights into the macroscopic structural connectivity of language. Eight putative WM fascicles for language were probed using a deterministic DTI-FT technique: the arcuate fascicle (AF), superior longitudinal fascicle (SLF), uncinate fascicle (UF), temporo-occipital fascicle, inferior fronto-occipital fascicle (IFOF), middle longitudinal fascicle (MdLF), frontal aslant fascicle and operculopremotor fascicle. Specific measurements (i.e. volume, length, fractional anisotropy) and precise cortical terminations were derived for each WM fascicle within both hemispheres. Connections between these WM fascicles and fMRI activations were studied to determine which WM fascicles are related to language. WM fascicle volumes showed asymmetries: leftward for the AF, temporoparietal segment of SLF and UF, and rightward for the frontoparietal segment of the SLF. The lateralization of the AF, IFOF and MdLF extended to differences in patterns of anatomical connections, which may relate to specific hemispheric abilities. The leftward asymmetry of the AF was correlated to the leftward asymmetry of fMRI activations, suggesting that the lateralization of the AF is a structural substrate of hemispheric language dominance. We found consistent connections between fMRI activations and terminations of the eight WM fascicles, providing a detailed description of the language connectome. WM fascicle terminations were also observed beyond fMRI-confirmed language areas and reached numerous cortical areas involved in different functional brain networks. These findings suggest that the reported WM fascicles are not exclusively involved in language and might be related to

  1. Combined DTI Tractography and Functional MRI Study of the Language Connectome in Healthy Volunteers: Extensive Mapping of White Matter Fascicles and Cortical Activations

    PubMed Central

    Schneider, Fabien; Boutet, Claire; Jean, Betty

    2016-01-01

    Despite a better understanding of brain language organization into large-scale cortical networks, the underlying white matter (WM) connectivity is still not mastered. Here we combined diffusion tensor imaging (DTI) fiber tracking (FT) and language functional magnetic resonance imaging (fMRI) in twenty healthy subjects to gain new insights into the macroscopic structural connectivity of language. Eight putative WM fascicles for language were probed using a deterministic DTI-FT technique: the arcuate fascicle (AF), superior longitudinal fascicle (SLF), uncinate fascicle (UF), temporo-occipital fascicle, inferior fronto-occipital fascicle (IFOF), middle longitudinal fascicle (MdLF), frontal aslant fascicle and operculopremotor fascicle. Specific measurements (i.e. volume, length, fractional anisotropy) and precise cortical terminations were derived for each WM fascicle within both hemispheres. Connections between these WM fascicles and fMRI activations were studied to determine which WM fascicles are related to language. WM fascicle volumes showed asymmetries: leftward for the AF, temporoparietal segment of SLF and UF, and rightward for the frontoparietal segment of the SLF. The lateralization of the AF, IFOF and MdLF extended to differences in patterns of anatomical connections, which may relate to specific hemispheric abilities. The leftward asymmetry of the AF was correlated to the leftward asymmetry of fMRI activations, suggesting that the lateralization of the AF is a structural substrate of hemispheric language dominance. We found consistent connections between fMRI activations and terminations of the eight WM fascicles, providing a detailed description of the language connectome. WM fascicle terminations were also observed beyond fMRI-confirmed language areas and reached numerous cortical areas involved in different functional brain networks. These findings suggest that the reported WM fascicles are not exclusively involved in language and might be related to

  2. Combined DTI Tractography and Functional MRI Study of the Language Connectome in Healthy Volunteers: Extensive Mapping of White Matter Fascicles and Cortical Activations.

    PubMed

    Vassal, François; Schneider, Fabien; Boutet, Claire; Jean, Betty; Sontheimer, Anna; Lemaire, Jean-Jacques

    2016-01-01

    Despite a better understanding of brain language organization into large-scale cortical networks, the underlying white matter (WM) connectivity is still not mastered. Here we combined diffusion tensor imaging (DTI) fiber tracking (FT) and language functional magnetic resonance imaging (fMRI) in twenty healthy subjects to gain new insights into the macroscopic structural connectivity of language. Eight putative WM fascicles for language were probed using a deterministic DTI-FT technique: the arcuate fascicle (AF), superior longitudinal fascicle (SLF), uncinate fascicle (UF), temporo-occipital fascicle, inferior fronto-occipital fascicle (IFOF), middle longitudinal fascicle (MdLF), frontal aslant fascicle and operculopremotor fascicle. Specific measurements (i.e. volume, length, fractional anisotropy) and precise cortical terminations were derived for each WM fascicle within both hemispheres. Connections between these WM fascicles and fMRI activations were studied to determine which WM fascicles are related to language. WM fascicle volumes showed asymmetries: leftward for the AF, temporoparietal segment of SLF and UF, and rightward for the frontoparietal segment of the SLF. The lateralization of the AF, IFOF and MdLF extended to differences in patterns of anatomical connections, which may relate to specific hemispheric abilities. The leftward asymmetry of the AF was correlated to the leftward asymmetry of fMRI activations, suggesting that the lateralization of the AF is a structural substrate of hemispheric language dominance. We found consistent connections between fMRI activations and terminations of the eight WM fascicles, providing a detailed description of the language connectome. WM fascicle terminations were also observed beyond fMRI-confirmed language areas and reached numerous cortical areas involved in different functional brain networks. These findings suggest that the reported WM fascicles are not exclusively involved in language and might be related to

  3. Active tectonics

    SciTech Connect

    Not Available

    1986-01-01

    This study is part of a series of Studies in Geophysics that have been undertaken for the Geophysics Research Forum by the Geophysics Study Committee. One purpose of each study is to provide assessments from the scientific community to aid policymakers in decisions on societal problems that involve geophysics. An important part of such assessments is an evaluation of the adequacy of current geophysical knowledge and the appropriateness of current research programs as a source of information required for those decisions. The study addresses our current scientific understanding of active tectonics --- particularly the patterns and rates of ongoing tectonic processes. Many of these processes cannot be described reasonably using the limited instrumental or historical records; however, most can be described adequately for practical purposes using the geologic record of the past 500,000 years. A program of fundamental research focusing especially on Quaternary tectonic geology and geomorphology, paleoseismology, neotectonics, and geodesy is recommended to better understand ongoing, active tectonic processes. This volume contains 16 papers. Individual papers are indexed separately on the Energy Database.

  4. Label-free electrochemiluminescence biosensor for ultrasensitive detection of telomerase activity in HeLa cells based on extension reaction and intercalation of Ru(phen)3 (2.).

    PubMed

    Lin, Yue; Yang, Linlin; Yue, Guiyin; Chen, Lifen; Qiu, Bin; Guo, Longhua; Lin, Zhenyu; Chen, Guonan

    2016-10-01

    Telomerase is one of the most common markers of human malignant tumors, such as uterine, stomach, esophageal, breast, colorectal, laryngeal squamous cell, thyroid, bladder, and so on. It is necessary to develop some sensitive but convenient detection methods for telomerase activity determination. In this study, a label-free and ultrasensitive electrochemiluminescence (ECL) biosensor has been fabricated to detect the activity of telomerase extracted from HeLa cells. Thiolated telomerase substrate (TS) primer was immobilized on the gold electrode surface through gold-sulfur (Au-S) interaction and then elongated by telomerase specifically. Then, it was hybridized with complementary DNA to form double-stranded DNA (dsDNA) fragments on the electrode surface, and Ru(phen)3 (2+) has been intercalated into the dsDNA grooves to act as the ECL probe. The enhanced ECL intensity has a linear relationship with the number of HeLa cells in the range of 5∼5000 and with a detection limit of 2 HeLa cells. The proposed ECL biosensor has high specificity to telomerase in the presence of common interferents. The relative standard deviations (RSDs) were <5 % at 100 HeLa cells. The proposed method provides a convenient approach for telomerase-related cancer screening or diagnosis.

  5. Extension of the energy range of experimental activation cross-sections data of deuteron induced nuclear reactions on indium up to 50MeV.

    PubMed

    Tárkányi, F; Ditrói, F; Takács, S; Hermanne, A; Ignatyuk, A V

    2015-11-01

    The energy range of our earlier measured activation cross-sections data of longer-lived products of deuteron induced nuclear reactions on indium were extended from 40MeV up to 50MeV. The traditional stacked foil irradiation technique and non-destructive gamma spectrometry were used. No experimental data were found in literature for this higher energy range. Experimental cross-sections for the formation of the radionuclides (113,110)Sn, (116m,115m,114m,113m,111,110g,109)In and (115)Cd are reported in the 37-50MeV energy range, for production of (110)Sn and (110g,109)In these are the first measurements ever. The experimental data were compared with the results of cross section calculations of the ALICE and EMPIRE nuclear model codes and of the TALYS 1.6 nuclear model code as listed in the on-line library TENDL-2014.

  6. Uncaria tomentosa Exerts Extensive Anti-Neoplastic Effects against the Walker-256 Tumour by Modulating Oxidative Stress and Not by Alkaloid Activity

    PubMed Central

    Dreifuss, Arturo Alejandro; Bastos-Pereira, Amanda Leite; Fabossi, Isabella Aviles; Lívero, Francislaine Aparecida dos Reis; Stolf, Aline Maria; Alves de Souza, Carlos Eduardo; Gomes, Liana de Oliveira; Constantin, Rodrigo Polimeni; Furman, Aline Emmer Ferreira; Strapasson, Regiane Lauriano Batista; Teixeira, Simone; Zampronio, Aleksander Roberto; Muscará, Marcelo Nicolás; Stefanello, Maria Elida Alves; Acco, Alexandra

    2013-01-01

    This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively. The cancer model was the subcutaneous inoculation of Walker-256 tumour cells in the pelvic limb of male Wistar rat. Subsequently to the inoculation, gavage with BHE extract (50 mg.kg−1) or its fractions (as per the yield of the fractioning process) or vehicle (Control) was performed during 14 days. Baseline values, corresponding to individuals without tumour or treatment with UT, were also included. After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF-α level in liver and tumour homogenates, and survival rates were analysed. Both the BHE extract and its BuOH fraction successfully reduced tumour weight and volume, and modulated anti-oxidant systems. The hepatic TNF-α level indicated a greater effect from the BHE extract as compared to its BuOH fraction. Importantly, both the BHE extract and its BuOH fraction increased the survival time of the tumour-bearing animals. Inversely, the CHCl3 fraction was ineffective. These data represent an in vivo demonstration of the importance of the modulation of oxidative stress as part of the anti-neoplastic activity of UT, as well as constitute evidence of the lack of activity of isolated POAs in the primary tumour of this tumour lineage. These effects are possibly resulting from a synergic combination of substances, most of them with antioxidant properties. PMID:23408945

  7. Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity.

    PubMed

    Dreifuss, Arturo Alejandro; Bastos-Pereira, Amanda Leite; Fabossi, Isabella Aviles; Lívero, Francislaine Aparecida Dos Reis; Stolf, Aline Maria; Alves de Souza, Carlos Eduardo; Gomes, Liana de Oliveira; Constantin, Rodrigo Polimeni; Furman, Aline Emmer Ferreira; Strapasson, Regiane Lauriano Batista; Teixeira, Simone; Zampronio, Aleksander Roberto; Muscará, Marcelo Nicolás; Stefanello, Maria Elida Alves; Acco, Alexandra

    2013-01-01

    This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively. The cancer model was the subcutaneous inoculation of Walker-256 tumour cells in the pelvic limb of male Wistar rat. Subsequently to the inoculation, gavage with BHE extract (50 mg.kg(-1)) or its fractions (as per the yield of the fractioning process) or vehicle (Control) was performed during 14 days. Baseline values, corresponding to individuals without tumour or treatment with UT, were also included. After treatment, tumour volume and mass, plasma biochemistry, oxidative stress in liver and tumour, TNF-α level in liver and tumour homogenates, and survival rates were analysed. Both the BHE extract and its BuOH fraction successfully reduced tumour weight and volume, and modulated anti-oxidant systems. The hepatic TNF-α level indicated a greater effect from the BHE extract as compared to its BuOH fraction. Importantly, both the BHE extract and its BuOH fraction increased the survival time of the tumour-bearing animals. Inversely, the CHCl3 fraction was ineffective. These data represent an in vivo demonstration of the importance of the modulation of oxidative stress as part of the anti-neoplastic activity of UT, as well as constitute evidence of the lack of activity of isolated POAs in the primary tumour of this tumour lineage. These effects are possibly resulting from a synergic combination of substances, most of them with antioxidant properties.

  8. Sugar beet activities of the USDA-ARS East Lansing conducted in cooperation with Saginaw Research & Extension Center during 2013 (including Project 905)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Evaluation and rating plots were planted at the Saginaw Valley Research & Extension Center (SVREC) in Frankenmuth, MI in 2013 that focused on Cercospora leaf spot and Rhizoctonia seedling disease performance of a wide range of Beta vulgaris materials. Leaf spot trials were conducted in conjunction w...

  9. DAVIC activities

    NASA Astrophysics Data System (ADS)

    Fujiwara, Hiroshi

    1995-12-01

    DAVIC (Digital Audio Visual Council) is the defacto standardization organization established in Mar. 1994, based on international consensus for digital audio visual services. After completion of MPEG2 standardization, the broadcasting industry, the communication industry, the computer industry, and consumer electronics industry have started development of concrete services and products. Especially the interactive digital audio visual services, such as Video On Demand (VOD) or Near Video On Demand (NVOD), have become hot topics all over the world. Such interactive digital audio visual services are combined technologies of multi-media coding, digital transmission and computer networking. Therefore more than 150 organizations from all industry sectors have participated in DAVIC and are contributing from their own industrial contexts. DAVIC's basic policy is to use the available technologies specified by the other standards bodies as much as possible. So DAVIC's standardization activities have close relationship with ISO IEC/JTC1/SC29, ITU-T SG 9, ATM-Forum, IETF, IMA, DVB, etc. DAVIC is trying to specify Applications, Reference Models, Security, Usage Information Control, and the interfaces and protocols among the Content Provider, the Server, the core network, the access network, and the Set Top Unit. DAVIC's first goal is to specify DAVIC1.0 based on CFP1 (Call for Proposal) and CFP2 by Dec. 1995, and the next direction is under preparation for further progress based on CFP3 and CFP4.

  10. Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009).

    PubMed

    Beaton, Alan A; Kaack, Imogen H; Corr, Philip J

    2015-01-01

    The Annett Hand Preference Questionnaire (AHPQ) as modified by Briggs and Nebes was administered along with Carver and White's behavioural inhibition system (BIS) and behavioural activation system (BAS) scale and a shortened form of the Big Five personality questionnaire to 92 university students. After eliminating the data from five respondents who reported having changed handedness and one outlier, there was a significant sex difference in mean BIS scores, with females (n = 43) scoring higher than males (n = 43). Replicating the results of Wright, Hardie and Wilson, non-right-handers (n = 36) had significantly higher mean BIS score than right-handers (n = 50). Controlling for sex of participant, neuroticism and BAS sub-scale scores in hierarchical regression analyses left this BIS effect substantially unaffected. There was no handedness or sex difference on any of the three BAS sub-scales. Further analyses revealed no association between strength, as distinct from direction, of handedness and BIS (or BAS) scores. The findings are discussed with reference to recent developments in reinforcement sensitivity theory on which BIS/BAS variables are based.

  11. Novel Driving Method for Two-Dimensional and Three-Dimensional Switchable Active Matrix Organic Light-Emitting Diode Displays for Emission and Programming Time Extension

    NASA Astrophysics Data System (ADS)

    In, Hai-Jung; Kwon, Oh-Kyong

    2012-03-01

    A novel driving method for two-dimensional (2D) and three-dimensional (3D) switchable active matrix organic light-emitting diode (AMOLED) displays is proposed to extend emission time and data programming time during 3D display operation. The proposed pixel consists of six thin-film transistors (TFTs) and two capacitors, and the aperture ratio of the pixel is 45.8% under 40-in. full-high-definition television condition. By increasing emission time and programming time, the flicker problem can be reduced and the lifetime of AMOLED displays can be extended owing to the decrease in emission current density. Simulation results show that the emission current error range from -0.4 to 1.6% is achieved when the threshold voltage variation of driving TFTs is in the range from -1.0 to 1.0 V, and the emission current error is 1.0% when the power line IR-drop is 2.0 V.

  12. Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009).

    PubMed

    Beaton, Alan A; Kaack, Imogen H; Corr, Philip J

    2015-01-01

    The Annett Hand Preference Questionnaire (AHPQ) as modified by Briggs and Nebes was administered along with Carver and White's behavioural inhibition system (BIS) and behavioural activation system (BAS) scale and a shortened form of the Big Five personality questionnaire to 92 university students. After eliminating the data from five respondents who reported having changed handedness and one outlier, there was a significant sex difference in mean BIS scores, with females (n = 43) scoring higher than males (n = 43). Replicating the results of Wright, Hardie and Wilson, non-right-handers (n = 36) had significantly higher mean BIS score than right-handers (n = 50). Controlling for sex of participant, neuroticism and BAS sub-scale scores in hierarchical regression analyses left this BIS effect substantially unaffected. There was no handedness or sex difference on any of the three BAS sub-scales. Further analyses revealed no association between strength, as distinct from direction, of handedness and BIS (or BAS) scores. The findings are discussed with reference to recent developments in reinforcement sensitivity theory on which BIS/BAS variables are based. PMID:25697855

  13. Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.

    PubMed

    Pérez-Núñez, Ramón; Barraza, Natalia; Gonzalez-Jamett, Arlek; Cárdenas, Ana Maria; Barnier, Jean-Vianney; Caviedes, Pablo

    2016-07-01

    In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as altered neuronal function in DS. Lately, the disruption of cellular signaling and regulatory pathways has been implicated in DS pathophysiology, and many of such pathways may represent common targets for diverse DS-related genes, which could in turn represent attractive therapeutical targets. In this regard, one DS-related gene Down Syndrome Cell Adhesion Molecule (DSCAM), has important functions in neuronal proliferation, maturation, and synaptogenesis. p21-associated kinases (PAKs) appear as a most interesting possibility for study, as DSCAM is known to regulate the PAKs pathway. Hence, in DS, overexpressed DSCAM could deregulate PAKs activity and affect signaling pathways that regulate synaptic plasticity such as dendritic spine dynamics and axon guidance and growth. In the present work, we used an immortalized cell line derived from the cerebral cortex of an animal model of DS such as the trisomy 16 (Ts16) fetal mouse (named CTb), and a similar cell line established from a normal littermate (named CNh), to study the effect of DSCAM in the PAKs pathway. The present study shows that DSCAM is overexpressed in CTb cells by approximately twofold, compared to CNh cells. Congruently, PAK1, as well as its downstream effectors LIMK and cofilin, stay phosphorylated for longer periods after DSCAM activation in the CTb cells, leading to an altered actin dynamics, expressed as an increased basal F/G ratio and reduced neurite growth, in the trisomic condition. The present work presents the correlation between DSCAM gene overexpression and a dysregulation of the PAK pathway, resulting in altered morphological parameters of neuronal plasticity in the trisomic cell

  14. IASS Activity

    NASA Astrophysics Data System (ADS)

    Hojaev, Alisher S.; Ibragimova, Elvira M.

    2015-08-01

    It’s well known, astronomy in Uzbekistan has ancient roots and traditions (e.g., Mirzo Ulugh Beg, Abū al-Rayhān al-Bīrūnī, Abū ‘Abdallāh al-Khwārizmī) and astronomical heritage carefully preserved. Nowadays uzbek astronomers play a key role in scientific research but also in OAD and Decadal Plan activity in the Central Asia region. International Aerospace School (IASS) is an amazing and wonderful event held annually about 30 years. IASS is unique project in the region, and at the beginning we spent the Summer and Winter Schools. At present in the summer camp we gather about 50 teenage and undergraduate students over the country and abroad (France, Malaysia, Turkey, Azerbaijan, Pakistan, Russia, etc.). They are selected on the basis of tests of astronomy and space issues. During two weeks of IASS camp the invited scientists, cosmonauts and astronauts as well as other specialists give lectures and engage in practical exercises with IASS students in astronomy, including daily observations of the Sun and night sky observations with meniscus telescope, space research and exploration, aerospace modelling, preparation and presentation of original projects. This is important that IASS gives not theoretical grounds only but also practically train the students and the hands-on training is the major aims of IASS. Lectures and practice in the field of astronomy carried out with the direct involvement and generous assistance of Uranoscope Association (Paris, France). The current 26-th IASS is planned to held in July 2015.

  15. Activation Energy

    NASA Technical Reports Server (NTRS)

    Gadeken, Owen

    2002-01-01

    Teaming is so common in today's project management environment that most of us assume it comes naturally. We further assume that when presented with meaningful and challenging work, project teams will naturally engage in productive activity to complete their tasks. This assumption is expressed in the simple (but false) equation: Team + Work = Teamwork. Although this equation appears simple and straightforward, it is far from true for most project organizations whose reality is a complex web of institutional norms based on individual achievement and rewards. This is illustrated by the very first successful team experience from my early Air Force career. As a young lieutenant, I was sent to Squadron Officer School, which was the first in the series of Air Force professional military education courses I was required to complete during my career. We were immediately formed into teams of twelve officers. Much of the course featured competition between these teams. As the most junior member of my team, I quickly observed the tremendous pressure to show individual leadership capability. At one point early in the course, almost everyone in our group was vying to become the team leader. This conflict was so intense that it caused us to fail miserably in our first outdoor team building exercise. We spent so much time fighting over leadership that we were unable to complete any of the events on the outdoor obstacle course. This complete lack of success was so disheartening to me that I gave our team little hope for future success. What followed was a very intense period of bickering, conflict, and even shouting matches as our dysfunctional team tried to cope with our early failures and find some way to succeed. British physician and researcher Wilfred Bion (Experiences in Groups, 1961) discovered that there are powerful psychological forces inherent in all groups that divert from accomplishing their primary tasks. To overcome these restraining forces and use the potential

  16. Classroom Activity Connections: Lessons from Fluorescence

    ERIC Educational Resources Information Center

    MacCormac, Aoife; O'Brien, Emma; O'Kennedy, Richard

    2010-01-01

    This Classroom Activity Connections paper describes an extension to the "JCE" Classroom Activity #68 "Turning on the Light". A number of additional common items that display fluorescence under UV light are described, including fruits, vegetables, and seashells. Two classroom extensions on fluorescence are also described. From these activities,…

  17. An Active Introduction To Evolution.

    ERIC Educational Resources Information Center

    Lach, Michael; Loverude, Michael

    1998-01-01

    Presents a series of simple and inexpensive hands-on activities with a host of extension lesson ideas that can be used to actively introduce students to the scientific theory of evolution. Lessons are designed to thwart common student difficulties. Classes are structured around a predator-prey simulation game that creates a springboard for…

  18. Indices of electromyographic activity and the "slow" component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans.

    PubMed

    Garland, Stephen W; Wang, Wen; Ward, Susan A

    2006-07-01

    The control of pulmonary oxygen uptake (VO2) kinetics above the lactate threshold (LT) is complex and controversial. Above LT, VO2 for square-wave exercise is greater than predicted from the sub-LT VO2-WR relationship, reflecting the contribution of an additional "slow" component (VO2(sc)). Investigators have argued for a contribution to this slow component from the recruitment of fast-twitch muscle fibres, which are less aerobically efficient than slow-twitch fibres. Six healthy subjects performed a rapid-incremental bilateral knee-extension exercise test to the limit of tolerance for the estimation of VO2(peak), ventilatory threshold (VT), and the difference between VO2(peak) and VO2 at VT (Delta). Subjects then completed three repetitions of square-wave exercise at 30% of VT for 10 min (moderate intensity), and at VT + 25%Delta (heavy intensity) for 20 min. Pulmonary gas exchange was measured breath-by-breath. Surface EMG was recorded from m. rectus femoris; integrated EMG (IEMG) and mean power frequency (MPF) were derived for successive contractions. In comparison to moderate-intensity exercise, the phase 2 VO2 kinetics in heavy exercise were marginally slower than for moderate-intensity exercise (time constant (+/- SD) 25 +/- 9 and 22 +/- 10 s, respectively; NS), with a discernible VO2(sc) (VO2 difference between minutes 6 and 3 of exercise: 74 +/- 21 and 0 +/- 20 ml min(-1), respectively). However, there was no significant change in IEMG or MPF, either in the moderate domain or in the heavy domain over the period when the slow component was manifest. These observations argue against an appreciable preferential recruitment of fast-twitch units with high force-generating characteristics and fast sarcolemmal conduction velocities in concert with the development of the VO2 slow component during heavy-intensity knee-extensor exercise. The underlying mechanism(s) remains to be resolved.

  19. Control of Polarized Growth by the Rho Family GTPase Rho4 in Budding Yeast: Requirement of the N-Terminal Extension of Rho4 and Regulation by the Rho GTPase-Activating Protein Bem2

    PubMed Central

    Gong, Ting; Liao, Yuan; He, Fei; Yang, Yang; Yang, Dan-Dan; Chen, Xiang-Dong

    2013-01-01

    In the budding yeast Saccharomyces cerevisiae, Rho4 GTPase partially plays a redundant role with Rho3 in the control of polarized growth, as deletion of RHO4 and RHO3 together, but not RHO4 alone, caused lethality and a loss of cell polarity at 30°C. Here, we show that overexpression of the constitutively active rho4Q131L mutant in an rdi1Δ strain caused a severe growth defect and generated large, round, unbudded cells, suggesting that an excess of Rho4 activity could block bud emergence. We also generated four temperature-sensitive rho4-Ts alleles in a rho3Δ rho4Δ strain. These mutants showed growth and morphological defects at 37°C. Interestingly, two rho4-Ts alleles contain mutations that cause amino acid substitutions in the N-terminal region of Rho4. Rho4 possesses a long N-terminal extension that is unique among the six Rho GTPases in the budding yeast but is common in Rho4 homologs in other yeasts and filamentous fungi. We show that the N-terminal extension plays an important role in Rho4 function since rho3Δ rho4Δ61 cells expressing truncated Rho4 lacking amino acids (aa) 1 to 61 exhibited morphological defects at 24°C and a growth defect at 37°C. Furthermore, we show that Rho4 interacts with Bem2, a Rho GTPase-activating protein (RhoGAP) for Cdc42 and Rho1, by yeast two-hybrid, bimolecular fluorescence complementation (BiFC), and glutathione S-transferase (GST) pulldown assays. Bem2 specifically interacts with the GTP-bound form of Rho4, and the interaction is mediated by its RhoGAP domain. Overexpression of BEM2 aggravates the defects of rho3Δ rho4 mutants. These results suggest that Bem2 might be a novel GAP for Rho4. PMID:23264647

  20. Physical Activity (Exercise)

    MedlinePlus

    ... fitness. Your fitness routine should include aerobic and strength-training activities, and may also include stretching activities. Aerobic ... Examples include walking, jogging, bicycling, swimming, and tennis. Strength-training activities These activities increase the strength and endurance ...

  1. 200 Outdoor Science Activities, A Classroom Extension.

    ERIC Educational Resources Information Center

    Ontario Teachers' Federation, Toronto.

    To encourage teachers to use the out-of-doors in their teaching, this booklet has been prepared by the Ontario Teachers' Federation. It reviews basic approaches to out-of-doors instruction, types of field trips, teacher training and sources of instructional assistance, pre-planning and follow-up for a field trip, and points to consider in…

  2. [Adapting physical activities for an active retirement].

    PubMed

    Renaudie, François

    2016-01-01

    The benefits of doing adapted physical exercise for elderly people have been proven. For more than thirty years, the French Federation for an Active Retirement has been striving to help people age well by proposing multiple activities to remain in good health after the age of 50. Doctors, activity leaders and federal instructors are attentive to each individual's capacities. PMID:27449307

  3. Learning as Activity.

    ERIC Educational Resources Information Center

    Jonassen, David H.

    2002-01-01

    Integrates contemporary theories of learning into a theory of learning as activity. Explains ecological psychology, changes in understanding of learning, activity systems and activity theory (including the integration of consciousness and activity), and activity structure; and discusses learning as a cognitive and social process. (LRW)

  4. RNA-mediated gene activation

    PubMed Central

    Jiao, Alan L; Slack, Frank J

    2014-01-01

    The regulation of gene expression by non-coding RNAs (ncRNAs) has become a new paradigm in biology. RNA-mediated gene silencing pathways have been studied extensively, revealing diverse epigenetic and posttranscriptional mechanisms. In contrast, the roles of ncRNAs in activating gene expression remains poorly understood. In this review, we summarize the current knowledge of gene activation by small RNAs, long non-coding RNAs, and enhancer-derived RNAs, with an emphasis on epigenetic mechanisms. PMID:24185374

  5. Physical Activity Assessment

    Cancer.gov

    Current evidence convincingly indicates that physical activity reduces the risk of colon and breast cancer. Physical activity may also reduce risk of prostate cancer. Scientists are also evaluating potential relationships between physical activity and other cancers.

  6. Facts about Physical Activity

    MedlinePlus

    ... Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs Facts about Physical Activity ... Physical Activity Overweight & Obesity Healthy Weight Breastfeeding Micronutrient Malnutrition State and Local Programs File Formats Help: How ...

  7. Enzyme activities in activated sludge flocs.

    PubMed

    Yu, Guang-Hui; He, Pin-Jing; Shao, Li-Ming; Lee, Duu-Jong

    2007-12-01

    This study quantified the activities of enzymes in extracellular polymeric substances (EPS) and in pellets. Seven commonly adopted extraction schemes were utilized to extract from aerobic flocs the contained EPS, which were further categorized into loosely bound (LB) and tightly bound (TB) fractions. Ultrasonication effectively extracted the EPS from sludge flocs. Enzyme assay tests showed that the protease activity was localized mainly on the pellets, alpha-amylase and alpha-glucosidase activities were largely bound with LB-EPS, and few protease, alpha-amylase, or alpha-glucosidase activities were associated with the TB-EPS fraction. There exists no correlation between the biochemical compositions of EPS and the distribution of enzyme activities in the sludge matrix. The 44-65% of alpha-amylase and 59-100% of alpha-glucosidase activities noted with the LB-EPS indicate heterogeneous hydrolysis patterns in the sludge flocs with proteins and carbohydrates.

  8. Adapting Active Learning in Ethiopia

    ERIC Educational Resources Information Center

    Casale, Carolyn Frances

    2010-01-01

    Ethiopia is a developing country that has invested extensively in expanding its educational opportunities. In this expansion, there has been a drastic restructuring of its system of preparing teachers and teacher educators. Often, improving teacher quality is dependent on professional development that diversifies pedagogy (active learning). This…

  9. Active commuting to school

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Declines in physical activity levels have coincided with increasing rates of obesity in children. This is problematic because physical activity has been shown to attenuate weight gain in children. Active commuting to school is one way of increasing children's physical activity. However, given the hi...

  10. Home Activities for Fours.

    ERIC Educational Resources Information Center

    Ferguson-Florissant School District, Ferguson, MO.

    These home learning activity guides have been developed for parents to use with their 4-year-old children. Most of the activities require only household items that are often thrown away and can be recycled for learning activities. Some require no materials at all. The guides frequently begin with a discussion of home activities; progress through…

  11. [Positive Activities Campaign.

    ERIC Educational Resources Information Center

    Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Substance Abuse Prevention.

    This packet contains four pamphlets that are part of a campaign to encourage adults to provide and promote positive activities for youth and to serve as role models for young people. "Positive Activities: A Campaign for Youth" includes information on what positive activities are, how to get involved in helping to provide positive activities for…

  12. Increasing Youth Physical Activity with Activity Calendars

    ERIC Educational Resources Information Center

    Eckler, Seth

    2016-01-01

    Physical educators often struggle with ways to get their students to be active beyond the school day. One strategy to accomplish this is the use of physical activity calendars (PACs). The purpose of this article is to support the use of PACs and give practical advice for creating effective PACs.

  13. Acid Rain: Activities for Science Teachers.

    ERIC Educational Resources Information Center

    Johnson, Eric; And Others

    1983-01-01

    Seven complete secondary/college level acid rain activities are provided. Activities include overview; background information and societal implications; major concepts; student objectives; vocabulary/material lists; procedures; instructional strategies; and questions/discussion and extension suggestions. Activities consider effects of acid rain on…

  14. A heat-activated and thermoresistant telomerase activity in Leishmania major Friedlin.

    PubMed

    Galindo, Maria Mercedes; Rodriguez, Evelyn; Rojas, Maria Gabriela; Figarella, Katherine; Campelo, Riward; Ramírez, Jose Luis

    2009-07-01

    Here we studied the telomerase activity of the human parasite Leishmania major. In this organism we have detected a high activity of this enzyme once several parameters such as heat activation, sequence of extension primer, and protein concentration are adjusted. The activity was not only heat activated, but also very resistant to heat denaturation. We believe L. major telomerase is an important activity and it may provide an adequate drug therapy target. PMID:19426669

  15. The Active Solid Earth

    NASA Astrophysics Data System (ADS)

    Ebinger, Cynthia

    2016-04-01

    Dynamic processes in Earth's crust, mantle and core shape Earth's surface and magnetic field over time scales of seconds to millennia, and even longer time scales as recorded in the ca. 4 Ga rock record. Our focus is the earthquake-volcano deformation cycles that occur over human time scales, and their comparison with time-averaged deformation studies, with emphasis on mantle plume provinces where magma and volatile release and vertical tectonics are readily detectable. Active deformation processes at continental and oceanic rift and back arc zones provide critical constraints on mantle dynamics, the role of fluids (volatiles, magma, water), and plate rheology. For example, recent studies of the East African rift zone, which formed above one of Earth's largest mantle upwellings reveal that magma production and volatile release rates are comparable to those of magmatic arcs, the archetypal zones of continental crustal creation. Finite-length faults achieve some plate deformation, but magma intrusion in the form of dikes accommodates extension in continental, back-arc, and oceanic rifts, and intrusion as sills causes permanent uplift that modulates the local time-space scales of earthquakes and volcanoes. Volatile release from magma intrusion may reduce fault friction and permeability, facilitating aseismic slip and creating magma pathways. We explore the implications of active deformation studies to models of the time-averaged structure of plume and extensional provinces in continental and oceanic plate settings.

  16. Brain activation associated with active and passive lower limb stepping

    PubMed Central

    Jaeger, Lukas; Marchal-Crespo, Laura; Wolf, Peter; Riener, Robert; Michels, Lars; Kollias, Spyros

    2014-01-01

    Reports about standardized and repeatable experimental procedures investigating supraspinal activation in patients with gait disorders are scarce in current neuro-imaging literature. Well-designed and executed tasks are important to gain insight into the effects of gait-rehabilitation on sensorimotor centers of the brain. The present study aims to demonstrate the feasibility of a novel imaging paradigm, combining the magnetic resonance (MR)-compatible stepping robot (MARCOS) with sparse sampling functional magnetic resonance imaging (fMRI) to measure task-related BOLD signal changes and to delineate the supraspinal contribution specific to active and passive stepping. Twenty-four healthy participants underwent fMRI during active and passive, periodic, bilateral, multi-joint, lower limb flexion and extension akin to human gait. Active and passive stepping engaged several cortical and subcortical areas of the sensorimotor network, with higher relative activation of those areas during active movement. Our results indicate that the combination of MARCOS and sparse sampling fMRI is feasible for the detection of lower limb motor related supraspinal activation. Activation of the anterior cingulate and medial frontal areas suggests motor response inhibition during passive movement in healthy participants. Our results are of relevance for understanding the neural mechanisms underlying gait in the healthy. PMID:25389396

  17. Virucidal activity of an activated sludge supernatant.

    PubMed

    Rehn, Y; Schwartzbrod, L

    1993-09-01

    The virucidal activity of the activated sludge aqueous phase was studied from the time of initial inoculation with a poliovirus type 1 suspension and for durations of three and nine days. The mixtures were incubated in presence of a nutritive medium at 26 degrees C and samples were drawn at regular intervals of time for viral titration. The activated sludge supernatant (ASS) caused an important decrease of the titer of the poliovirus type 1 suspension especially after nine days of incubation. There was an average reduction of the viral titer of 79% after three days and 97% after nine days. When incubating the ASS with a nutritive medium before inoculating it, the viral decrease was much greater than when incubating without nutritive medium. When sterilizing the ASS before incubation and then inoculating it, no significant virucidal activity was observed (0% to 6%). Furthermore, when the ASS was subjected to a sterilization by filtration after incubation and was then inoculated, there existed a lower but not negligible viral inactivation (53% to 64%). The virucidal activity potentiality of the ASS is therefore due to microorganisms acting both directly as a support for viral particles adsorption and indirectly via the synthesis of substances with virucidal activity. When freezing and thawing the incubated ASS, and then sterilizing it by filtration before inoculation, the viral decrease reached 87% to 94%. This proves that the virucidal substances are only partly excreted by the microorganisms.

  18. Active magnetic regenerator

    DOEpatents

    Barclay, John A.; Steyert, William A.

    1982-01-01

    The disclosure is directed to an active magnetic regenerator apparatus and method. Brayton, Stirling, Ericsson, and Carnot cycles and the like may be utilized in an active magnetic regenerator to provide efficient refrigeration over relatively large temperature ranges.

  19. Preschoolers’ Physical Activity Behaviours

    PubMed Central

    Irwin, Jennifer D.; He, Meizi; Bouck, L. Michelle Sangster; Tucker, Patricia; Pollett, Graham L.

    2016-01-01

    Objectives To understand parents’ perspectives of their preschoolers’ physical activity behaviours. Methods A maximum variation sample of 71 parents explored their preschoolers’ physical activity behaviours through 10 semi-structured focus group discussions. Results Parents perceived Canada’s Physical Activity Guidelines for Children as inadequate; that their preschoolers get and need more than 30–90 minutes of activity daily; and that physical activity habits must be established during the preschool years. Nine barriers against and facilitators toward adequate physical activity were proposed: child’s age, weather, daycare, siblings, finances, time, society and safety, parents’ impact, and child’s activity preferences. Discussion The need for education and interventions that address current barriers are essential for establishing physical activity as a lifestyle behaviour during early childhood and, consequently, helping to prevent both childhood and adulthood obesity. PMID:16625802

  20. Balance Food and Activity

    MedlinePlus

    ... For Health Professionals Tools and Resources Promotional Materials Programming Materials Weight Management Nutrition Physical Activity Reduce Screen ... Training For Health Professionals Tools & Resources Promotional ... Programming Materials Weight Management Nutrition Physical Activity Reduce Screen ...

  1. Population Education. Awareness Activities.

    ERIC Educational Resources Information Center

    Brouse, Deborah E.

    1990-01-01

    Described are awareness activities that deal with human population growth, resources, and the environment. Activities include simulations, mathematical exercises, and discussions of the topic. Specific examples of what individuals can do to help are listed. (KR)

  2. Major operations and activities

    SciTech Connect

    Black, D.G.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the major operations and activities on the site. These operations and activities include site management, waste management, environmental restoration and corrective actions, and research and technology development.

  3. Active Fire Mapping Program

    MedlinePlus

    ... Incidents (Home) New Large Incidents Fire Detection Maps MODIS Satellite Imagery VIIRS Satellite Imagery Fire Detection GIS ... Data Web Services Latest Detected Fire Activity Other MODIS Products Frequently Asked Questions About Active Fire Maps ...

  4. Family Activities for Fitness

    ERIC Educational Resources Information Center

    Grosse, Susan J.

    2009-01-01

    This article discusses how families can increase family togetherness and improve physical fitness. The author provides easy ways to implement family friendly activities for improving and maintaining physical health. These activities include: walking, backyard games, and fitness challenges.

  5. Green Schools Activity Booklet.

    ERIC Educational Resources Information Center

    Sacramento Tree Foundation, CA.

    This collection of interdisciplinary hands-on activities covers a variety of topics related to trees and conservation. Twenty-four activities integrate the subjects of social studies, fine arts, science, language arts, math, geography, and music. Although activity instructions are not consistent they usually contain details on objectives and…

  6. Activity Sheets. Draft Copy.

    ERIC Educational Resources Information Center

    Duke Power Company, Educational Services Dept., Charlotte, NC.

    This document consists of energy vocabulary activities, three games, worksheets, laboratory activities/exercises, and an introductory classroom exercise designed to introduce energy concepts to students. Vocabulary activities focus on coal and energy consumption. The three games (with instructions) focus on various aspects of energy and energy…

  7. Bonus Activity Book.

    ERIC Educational Resources Information Center

    Learning, 1992

    1992-01-01

    Provides on-task activities to fill in unexpected extra moments in elementary classes. The activities require little preparation and take 5-15 minutes to complete. There are activities for math, language arts, social science, science, critical thinking, and computer. An outer space board game is also included. (SM)

  8. Climate Change: An Activity.

    ERIC Educational Resources Information Center

    Lewis, Garry

    1995-01-01

    Presents a segment of the Geoscience Education booklet, Climate Change, that contains information and activities that enable students to gain a better appreciation of the possible effects human activity has on the Earth's climate. Describes the Terrace Temperatures activity that leads students through an investigation using foraminifera data to…

  9. Active Learning Crosses Generations.

    ERIC Educational Resources Information Center

    Woodard, Diane K.

    2002-01-01

    Describes the benefits of intergenerational programs, highlighting a child care program that offers age-appropriate and mutually beneficial activities for children and elders within a nearby retirement community. The program has adopted High/Scope's active learning approach to planning and implementing activities that involve both generations. The…

  10. Activity Theory and Ontology

    ERIC Educational Resources Information Center

    Peim, Nick

    2009-01-01

    This paper seeks to re-examine Yrio Engestrom's activity theory as a technology of knowledge designed to enable positive transformations of specific practices. The paper focuses on a key paper where Engestrom defines the nature and present state of activity theory. Beginning with a brief account of the relations between activity theory and…

  11. Highlights of 1981 activities

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The highlights of NASA's 1981 activities are presented, including the results of the two flights of the space shuttle Columbia and the Voyager 2 encounter with Saturn. Accomplishments in the areas of space transportation operations; space science; aeronautical, energy, and space research and development; as well as space tracking, international activities, and 1981 launch activities are discussed.

  12. Measurement of Physical Activity.

    ERIC Educational Resources Information Center

    Dishman, Rod K.; Washburn, Richard A.; Schoeller, Dale A.

    2001-01-01

    Valid assessment of physical activity must be unobtrusive, practical to administer, and specific about physical activity type, frequency, duration, and intensity. Assessment methods can be categorized according to whether they provide direct or indirect (e.g., self-report) observation of physical activity, body motion, physiological response…

  13. FL Activities & Festivals.

    ERIC Educational Resources Information Center

    American Council on the Teaching of Foreign Languages, Hastings-on-Hudson, NY.

    A collection of student, class, and school foreign language activities suggests a variety of projects and describes three specific school efforts. The suggested activities include: (1) individual student efforts such as writing to pen-pals; (2) group activities such as a foreign language auction or sing-along; (3) group projects for the school…

  14. Technology Learning Activities I.

    ERIC Educational Resources Information Center

    International Technology Education Association, Reston, VA.

    This guide contains 30 technology learning activities. Activities may contain all or some of the following: an introduction, objectives, materials and equipment, challenges, limitations, notes and investigations, resources and references used, and evaluation ideas. Activity titles are: (1) Occupations in Construction Technology; (2) Designing a…

  15. Woodsy Owl Activity Guide.

    ERIC Educational Resources Information Center

    Forest Service (USDA), Washington, DC.

    This guide offers teachers and after-school group leaders 12 fun and engaging activities. Activities feature lessons on trees, water, wind, the earth, food, and waste. The activities are designed to help children aged 5-8 become more aware of the natural environment and fundamental conservation principles. Titles of children's books are embedded…

  16. Tea enhances insulin activity.

    PubMed

    Anderson, Richard A; Polansky, Marilyn M

    2002-11-20

    The most widely known health benefits of tea relate to the polyphenols as the principal active ingredients in protection against oxidative damage and in antibacterial, antiviral, anticarcinogenic, and antimutagenic activities, but polyphenols in tea may also increase insulin activity. The objective of this study was to determine the insulin-enhancing properties of tea and its components. Tea, as normally consumed, was shown to increase insulin activity >15-fold in vitro in an epididymal fat cell assay. Black, green, and oolong teas but not herbal teas, which are not teas in the traditional sense because they do not contain leaves of Camellia senensis, were all shown to increase insulin activity. High-performance liquid chromatography fractionation of tea extracts utilizing a Waters SymmetryPrep C18 column showed that the majority of the insulin-potentiating activity for green and oolong teas was due to epigallocatechin gallate. For black tea, the activity was present in several regions of the chromatogram corresponding to, in addition to epigallocatechin gallate, tannins, theaflavins, and other undefined compounds. Several known compounds found in tea were shown to enhance insulin with the greatest activity due to epigallocatechin gallate followed by epicatechin gallate, tannins, and theaflavins. Caffeine, catechin, and epicatechin displayed insignificant insulin-enhancing activities. Addition of lemon to the tea did not affect the insulin-potentiating activity. Addition of 5 g of 2% milk per cup decreased the insulin-potentiating activity one-third, and addition of 50 g of milk per cup decreased the insulin-potentiating activity approximately 90%. Nondairy creamers and soy milk also decreased the insulin-enhancing activity. These data demonstrate that tea contains in vitro insulin-enhancing activity and the predominant active ingredient is epigallocatechin gallate. PMID:12428980

  17. 76 FR 6471 - Agency Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... COMMISSION Agency Information Collection Activities AGENCY: Equal Employment Opportunity Commission. ACTION: Notice of Information Collection --Extension Without Change: Local Union Report (EEO-3). SUMMARY: In... will be posted without change, including any personal information you provide. Copies of...

  18. 77 FR 65548 - Agency Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... revision to the previously approved EEO-5 under the PRA's emergency processing procedures. 77 FR 39238... COMMISSION Agency Information Collection Activities AGENCY: Equal Employment Opportunity Commission. ACTION: Notice of Information Collection--Extension Without Change: Elementary-Secondary Staff Information...

  19. 76 FR 6470 - Agency Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... COMMISSION Agency Information Collection Activities AGENCY: Equal Employment Opportunity Commission. ACTION: Notice of Information Collection--Request For An Extension Without Change: State and Local Government Information Report (EEO-4). SUMMARY: In accordance with the Paperwork Reduction Act, the Equal...

  20. 76 FR 6470 - Agency Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... OPPORTUNITY COMMISSION Agency Information Collection Activities AGENCY: Equal Employment Opportunity Commission. ACTION: Notice of Information Collection--Extension Without Change: Elementary-Secondary Staff Information Report (EEO-5). SUMMARY: In accordance with the Paperwork Reduction Act, the Equal...

  1. Vestibular activation of sympathetic nerve activity

    NASA Technical Reports Server (NTRS)

    Ray, C. A.; Carter, J. R.

    2003-01-01

    AIM: The vestibulosympathetic reflex refers to sympathetic nerve activation by the vestibular system. Animal studies indicate that the vestibular system assists in blood pressure regulation during orthostasis. Although human studies clearly demonstrate activation of muscle sympathetic nerve activity (MSNA) during engagement of the otolith organs, the role of the vestibulosympathetic reflex in maintaining blood pressure during orthostasis is not well-established. Examination of the vestibulosympathetic reflex with other cardiovascular reflexes indicates that it is a powerful and independent reflex. Ageing, which is associated with an increased risk for orthostatic hypotension, attenuates the vestibulosympathetic reflex. The attenuated reflex is associated with a reduction in arterial pressure. CONCLUSION: These findings suggest that the vestibulosympathetic reflex assists in blood pressure regulation in humans, but future studies examining this reflex in other orthostatically intolerant populations are necessary to address this hypothesis.

  2. 76 FR 6469 - Agency Information Collection Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... COMMISSION Agency Information Collection Activities AGENCY: Equal Employment Opportunity Commission. ACTION: Notice of Information Collection--Extension Without Change: Employer Information Report (EEO-1). SUMMARY... three-year extension of the Employer Information Report (EEO-1). DATES: Written comments on this...

  3. Physical Activity and Albuminuria

    PubMed Central

    Robinson, Emily S.; Fisher, Naomi D.; Forman, John P.; Curhan, Gary C.

    2010-01-01

    Higher urinary albumin excretion predicts future cardiovascular disease, hypertension, and chronic kidney disease. Physical activity improves endothelial function so activity may reduce albuminuria. Among diabetics, physical activity decreases albuminuria. In nondiabetics, prior studies have shown no association. The authors explored the cross-sectional association between physical activity and albuminuria in 3,587 nondiabetic women in 2 US cohorts, the Nurses’ Health Study I in 2000 and the Nurses’ Health Study II in 1997. Physical activity was expressed as metabolic equivalents per week. The outcome was the top albumin/creatinine ratio (ACR) decile. Multivariate logistic regression was used. Secondary analyses explored the ACR association with strenuous activity and walking. The mean age was 58.6 years. Compared with women in the lowest physical activity quintile, those in the highest quintile had a multivariate-adjusted odds ratio for the top ACR decile of 0.65 (95% confidence interval (CI): 0.46, 0.93). The multivariate-adjusted odds ratio for the top ACR decile for those with greater than 210 minutes per week of strenuous activity compared with no strenuous activity was 0.61 (95% CI: 0.37, 0.99), and for those in the highest quintile of walking compared with the lowest quintile, it was 0.69 (95% CI: 0.47, 1.02). Greater physical activity is associated with a lower ACR in nondiabetic women. PMID:20133515

  4. Activated carbon from biomass

    NASA Astrophysics Data System (ADS)

    Manocha, S.; Manocha, L. M.; Joshi, Parth; Patel, Bhavesh; Dangi, Gaurav; Verma, Narendra

    2013-06-01

    Activated carbon are unique and versatile adsorbents having extended surface area, micro porous structure, universal adsorption effect, high adsorption capacity and high degree of surface reactivity. Activated carbons are synthesized from variety of materials. Most commonly used on a commercial scale are cellulosic based precursors such as peat, coal, lignite wood and coconut shell. Variation occurs in precursors in terms of structure and carbon content. Coir having very low bulk density and porous structure is found to be one of the valuable raw materials for the production of highly porous activated carbon and other important factor is its high carbon content. Exploration of good low cost and non conventional adsorbent may contribute to the sustainability of the environment and offer promising benefits for the commercial purpose in future. Carbonization of biomass was carried out in a horizontal muffle furnace. Both carbonization and activation were performed in inert nitrogen atmosphere in one step to enhance the surface area and to develop interconnecting porosity. The types of biomass as well as the activation conditions determine the properties and the yield of activated carbon. Activated carbon produced from biomass is cost effective as it is easily available as a waste biomass. Activated carbon produced by combination of chemical and physical activation has higher surface area of 2442 m2/gm compared to that produced by physical activation (1365 m2/gm).

  5. Physiologic activities of the contact activation system.

    PubMed

    Schmaier, Alvin H

    2014-05-01

    The plasma contact activation (CAS) and kallikrein/kinin (KKS) systems consist of 4 proteins: factor XII, prekallikrein, high molecular weight kininogen, and the bradykinin B2 receptor. Murine genetic deletion of factor XII (F12(-/-)), prekallikrein (Klkb1(-/-)), high molecular weight kininogen (Kgn1(-/-)) and the bradykinin B2 receptor (Bdkrb2(-/-)) yield animals protected from thrombosis. With possible exception of F12(-/-) and Kgn1(-/-) mice, the mechanism(s) for thrombosis protection is not reduced contact activation. Bdkrb2(-/-) mice are best characterized and they are protected from thrombosis through over expression of components of the renin angiotensin system (RAS) leading to elevated prostacyclin with vascular and platelet inhibition. Alternatively, prolylcarboxypeptidase, a PK activator and degrader of angiotensin II, when deficient in the mouse leads to a prothrombotic state. Its mechanism for increased thrombosis also is mediated in part by components of the RAS. These observations suggest that thrombosis in mice of the CAS and KKS are mediated in part through the RAS and independent of reduced contact activation. PMID:24759141

  6. Marine Biology Activities. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Pauls, John

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  7. Lightning Activities and Earthquakes

    NASA Astrophysics Data System (ADS)

    Liu, Jann-Yenq

    2016-04-01

    The lightning activity is one of the key parameters to understand the atmospheric electric fields and/or currents near the Earth's surface as well as the lithosphere-atmosphere coupling during the earthquake preparation period. In this study, to see whether or not lightning activities are related to earthquakes, we statistically examine lightning activities 30 days before and after 78 land and 230 sea M>5.0 earthquakes in Taiwan during the 12-year period of 1993-2004. Lightning activities versus the location, depth, and magnitude of earthquakes are investigated. Results show that lightning activities tend to appear around the forthcoming epicenter and are significantly enhanced a few, especially 17-19, days before the M>6.0 shallow (depth D< 20 km) land earthquakes. Moreover, the size of the area around the epicenter with the statistical significance of lightning activity enhancement is proportional to the earthquake magnitude.

  8. Stochastic thermodynamics for active matter

    NASA Astrophysics Data System (ADS)

    Speck, Thomas

    2016-05-01

    The theoretical understanding of active matter, which is driven out of equilibrium by directed motion, is still fragmental and model oriented. Stochastic thermodynamics, on the other hand, is a comprehensive theoretical framework for driven systems that allows to define fluctuating work and heat. We apply these definitions to active matter, assuming that dissipation can be modelled by effective non-conservative forces. We show that, through the work, conjugate extensive and intensive observables can be defined even in non-equilibrium steady states lacking a free energy. As an illustration, we derive the expressions for the pressure and interfacial tension of active Brownian particles. The latter becomes negative despite the observed stable phase separation. We discuss this apparent contradiction, highlighting the role of fluctuations, and we offer a tentative explanation.

  9. Synopsis of Cathode #4 Activation

    SciTech Connect

    Kwan, Joe; Ekdahl, C.; Harrison, J.; Kwan, J.; Leitner, M.; McCruistian, T.; Mitchell, R.; Prichard, B.; Roy, P.

    2006-05-26

    The purpose of this report is to describe the activation of the fourth cathode installed in the DARHT-II Injector. Appendices have been used so that an extensive amount of data could be included without danger of obscuring important information contained in the body of the report. The cathode was a 612 M type cathode purchased from Spectra-Mat. Section II describes the handling and installation of the cathode. Section III is a narrative of the activation based on information located in the Control Room Log Book supplemented with time plots of pertinent operating parameters. Activation of the cathode was performed in accordance with the procedure listed in Appendix A. The following sections provide more details on the total pressure and constituent partial pressures in the vacuum vessel, cathode heater power/filament current, and cathode temperature.

  10. Thermally Activated Driver

    NASA Technical Reports Server (NTRS)

    Kinard, William H.; Murray, Robert C.; Walsh, Robert F.

    1987-01-01

    Space-qualified, precise, large-force, thermally activated driver (TAD) developed for use in space on astro-physics experiment to measure abundance of rare actinide-group elements in cosmic rays. Actinide cosmic rays detected using thermally activated driver as heart of event-thermometer (ET) system. Thermal expansion and contraction of silicone oil activates driver. Potential applications in fluid-control systems where precise valve controls are needed.

  11. Activated recombinant adenovirus proteinases

    SciTech Connect

    Anderson, C.W.; Mangel, W.F.

    1999-08-10

    This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described. 29 figs.

  12. Activated recombinant adenovirus proteinases

    DOEpatents

    Anderson, Carl W.; Mangel, Walter F.

    1999-08-10

    This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

  13. Active unilateral condylar hyperplasia.

    PubMed

    Luz, J G; de Rezende, J R; de Araújo, V C; Chilvarquer, I

    1994-01-01

    Two cases of active unilateral condylar hyperplasia which were treated with condylectomy alone are presented. The first case was an adult form and the other a juvenile form. Both were classified as active by using 99Tc bone scintigraphy. Clinical and radiographic features of both cases conformed to the hemimandibular hypertrophy type. Satisfactory facial symmetry and dental occlusion were achieved. Histopathological data confirmed the activity of the articular cartilage layers. PMID:8181091

  14. Activity in distant comets

    NASA Technical Reports Server (NTRS)

    Luu, Jane X.

    1992-01-01

    Activity in distant comets remains a mystery in the sense that we still have no complete theory to explain the various types of activity exhibited by different comets at large distances. This paper explores the factors that should play a role in determining activity in a distant comet, especially in the cases of comet P/Tempel 2, comet Schwassmann-Wachmann 1, and 2060 Chiron.

  15. Crew activities in space

    NASA Technical Reports Server (NTRS)

    Bluford, G. S., Jr.

    1981-01-01

    One of the mission requirements of the Space Shuttle is to serve as a working platform for experiments in space. Many of these experiments will be performed by crewmembers (mission specialists and payload specialists) in a general purpose laboratory called Spacelab. All nonexperiment-related activities or housekeeping activities will be done in the Orbiter, while most of the mission-related activities (experiments) will be done in Spacelab. In order for experimenters to design their experiments to best utilize the capabilities of the Orbiter, the Spacelab, and the crew, the working environment in the Orbiter and in Spacelab is described. In addition, the housekeeping activities required of the crew are summarized.

  16. Physical Activity and Cancer

    MedlinePlus

    ... of scientists, ranging from experts in basic biological science to those with expertise in community behavioral interventions to increase physical activity. This combination of scientists and expertise will ...

  17. NASA metrication activities

    NASA Technical Reports Server (NTRS)

    Vlannes, P. N.

    1978-01-01

    NASA's organization and policy for metrification, history from 1964, NASA participation in Federal agency activities, interaction with nongovernmental metrication organizations, and the proposed metrication assessment study are reviewed.

  18. Environmental Education Activity Sheets 1-11.

    ERIC Educational Resources Information Center

    Halsey, Clifton F.; And Others

    These activity sheets, developed by personnel of the Agricultural Extension Service of the University of Minnesota, were designed for youth group campers but may be used by other populations and individuals. Each activity sheet focuses on a separate topic: (1) Selecting Suitable Uses for Land, (2) Measuring the Steepness of Land, (3) Determining…

  19. Oriented active shape models.

    PubMed

    Liu, Jiamin; Udupa, Jayaram K

    2009-04-01

    Active shape models (ASM) are widely employed for recognizing anatomic structures and for delineating them in medical images. In this paper, a novel strategy called oriented active shape models (OASM) is presented in an attempt to overcome the following five limitations of ASM: 1) lower delineation accuracy, 2) the requirement of a large number of landmarks, 3) sensitivity to search range, 4) sensitivity to initialization, and 5) inability to fully exploit the specific information present in the given image to be segmented. OASM effectively combines the rich statistical shape information embodied in ASM with the boundary orientedness property and the globally optimal delineation capability of the live wire methodology of boundary segmentation. The latter characteristics allow live wire to effectively separate an object boundary from other nonobject boundaries with similar properties especially when they come very close in the image domain. The approach leads to a two-level dynamic programming method, wherein the first level corresponds to boundary recognition and the second level corresponds to boundary delineation, and to an effective automatic initialization method. The method outputs a globally optimal boundary that agrees with the shape model if the recognition step is successful in bringing the model close to the boundary in the image. Extensive evaluation experiments have been conducted by utilizing 40 image (magnetic resonance and computed tomography) data sets in each of five different application areas for segmenting breast, liver, bones of the foot, and cervical vertebrae of the spine. Comparisons are made between OASM and ASM based on precision, accuracy, and efficiency of segmentation. Accuracy is assessed using both region-based false positive and false negative measures and boundary-based distance measures. The results indicate the following: 1) The accuracy of segmentation via OASM is considerably better than that of ASM; 2) The number of landmarks

  20. Active Flow Control Activities at NASA Langley

    NASA Technical Reports Server (NTRS)

    Anders, Scott G.; Sellers, William L., III; Washburn, Anthony E.

    2004-01-01

    NASA Langley continues to aggressively investigate the potential advantages of active flow control over more traditional aerodynamic techniques. This paper provides an update to a previous paper and describes both the progress in the various research areas and the significant changes in the NASA research programs. The goals of the topics presented are focused on advancing the state of knowledge and understanding of controllable fundamental mechanisms in fluids as well as to address engineering challenges. An organizational view of current research activities at NASA Langley in active flow control as supported by several projects is presented. On-center research as well as NASA Langley funded contracts and grants are discussed at a relatively high level. The products of this research are to be demonstrated either in bench-top experiments, wind-tunnel investigations, or in flight as part of the fundamental NASA R&D program and then transferred to more applied research programs within NASA, DOD, and U.S. industry.

  1. Clinical efficacy, radiographic and safety findings through 2 years of golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of the randomised, placebo-controlled GO-REVEAL study

    PubMed Central

    Kavanaugh, Arthur; McInnes, Iain B; Mease, Philip J; Krueger, Gerald G; Gladman, Dafna D; van der Heijde, Désirée; Mudivarthy, Surekha; Xu, Weichun; Mack, Michael; Xu, Zhenhua; Beutler, Anna

    2013-01-01

    Objectives To assess long-term golimumab efficacy/safety in patients with active psoriatic arthritis (PsA). Methods Adult PsA patients (≥3 swollen, ≥3 tender joints, active psoriasis) were randomly assigned to subcutaneous injections of placebo, golimumab 50 mg or 100 mg every 4 weeks (q4wks) through week 20. All patients received golimumab 50 or 100 mg beginning week 24. Findings through 2 years are reported. Efficacy evaluations included ≥20% improvement in American College of Rheumatology (ACR20) response, good/moderate response in Disease Activity Scores incorporating 28 joints and C-reactive protein (DAS28-CRP), ≥75% improvement in Psoriasis Area and Severity Index (PASI75) and changes in PsA-modified Sharp/van der Heijde scores (SHS). Results Golimumab treatment through 2 years was effective in maintaining clinical response (response rates: ACR20 63%–70%, DAS28-CRP 77%–86%, PASI75 56%–72%) and inhibiting radiographic progression (mean change in PsA-modified SHS in golimumab-treated patients: −0.36), with no clear difference between doses. No new safety signals were identified through 2 years. With the study's tuberculosis screening and prophylactic measures, no patient developed active tuberculosis through 2 years. Conclusions Golimumab 50 and 100 mg for up to 2 years yielded sustained clinical and radiographic efficacy when administered to patients with active PsA. Increasing the golimumab dose from 50 to 100 mg q4wks added limited benefit. Golimumab safety through up to 2 years was consistent with other antitumour necrosis factor α agents used to treat PsA. Treatment of patients with latent tuberculosis identified at baseline appeared to be effective in inhibiting the development of active tuberculosis. PMID:23161902

  2. A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism.

    PubMed

    Egelund, R; Petersen, T E; Andreasen, P A

    2001-02-01

    The formation of stable complexes between serpins and their target serine proteinases indicates formation of an ester bond between the proteinase active-site serine and the serpin P1 residue [Egelund, R., Rodenburg, K.W., Andreasen, P.A., Rasmussen, M.S., Guldberg, R.E. & Petersen, T.E. (1998) Biochemistry 37, 6375-6379]. An important question concerning serpin inhibition is the contrast between the stability of the ester bond in the complex and the rapid hydrolysis of the acyl-enzyme intermediate in general serine proteinase-catalysed peptide bond hydrolysis. To answer this question, we used limited proteolysis to detect conformational differences between free urokinase-type plasminogen activator (uPA) and uPA in complex with plasminogen activator inhibitor-1 (PAI-1). Whereas the catalytic domain of free uPA, pro-uPA, uPA in complex with non-serpin inhibitors and anhydro-uPA in a non-covalent complex with PAI-1 was resistant to proteolysis, the catalytic domain of PAI-1-complexed uPA was susceptible to proteolysis. The cleavage sites for four different proteinases were localized in specific areas of the C-terminal beta-barrel of the catalytic domain of uPA, providing evidence that the serpin inhibitory mechanism involves a serpin-induced massive rearrangement of the proteinase active site, including the specificity pocket, the oxyanion hole, and main-chain binding area, rendering the proteinase unable to complete the normal hydrolysis of the acyl-enzyme intermediate. The distorted region includes the so-called activation domain, also known to change conformation on zymogen activation.

  3. Activity Book: Ocean Ecology.

    ERIC Educational Resources Information Center

    Learning, 1992

    1992-01-01

    Presents a collection of activities to help elementary students study ocean ecology. The activities have students investigate ocean inhabitants, analyze animal adaptations, examine how temperature and saltiness affect ocean creatures, and learn about safeguarding the sea. Student pages offer reproducible learning sheets. (SM)

  4. [Field Learning Activities].

    ERIC Educational Resources Information Center

    Nolde Forest Environmental Education Center, Reading, PA.

    Seventy field activities, pertinent to outdoor, environmental studies, are described in this compilation. Designed for elementary and junior high school students, the activities cover many discipline areas--science, social studies, language arts, health, history, mathematics, and art--and many are multidisciplinary in use. Topics range from soil…

  5. Rainy Day Activities.

    ERIC Educational Resources Information Center

    Texas Child Care, 1997

    1997-01-01

    Experienced caregivers plan ahead for rainy days. This article describes specific rainy day activities for young children, such as books and crafts to learn about rain (rain in a jar, making a rainbow), simple cooking activities (taffy pull, cinnamon candy tea), and games (mummy wrap, hunt the thimble, rain lotto). (EV)

  6. Activities of the ILO.

    ERIC Educational Resources Information Center

    Labour Education, 1984

    1984-01-01

    Seven articles on International Labour Organization (ILO) activities cover study groups at ILO headquarters, a Philippine rural workers seminar, women's participation in Central American union activities, worksite courses in India, and seminars and symposia in Cape Verde, Mauritius, and Sierra Leone. (SK)

  7. Active Students in Webinars

    ERIC Educational Resources Information Center

    Kolås, Line; Nordseth, Hugo; Yri, Jørgen Sørlie

    2015-01-01

    To ensure student activity in webinars we have defined 10 learning tasks focusing on production and communication e.g. collaborative writing, discussion and polling, and investigated how the technology supports the learning activities. The three project partners in the VisPed-project use different video-conferencing systems, and we analyzed how it…

  8. The Activity of Trypsin

    ERIC Educational Resources Information Center

    Russo, Salvatore F.; Holzman, Tom

    1977-01-01

    Describes an experiment that illustrates the following points concerning the experimental determination of trypsin activity: (1) there is a difference in basing enzyme concentration on weight, absorbance, or active sites; and (2) the method of expressing enzyme concentration determines the value of specific, molecular, and catalytic center…

  9. Emotionally Intense Science Activities

    ERIC Educational Resources Information Center

    King, Donna; Ritchie, Stephen; Sandhu, Maryam; Henderson, Senka

    2015-01-01

    Science activities that evoke positive emotional responses make a difference to students' emotional experience of science. In this study, we explored 8th Grade students' discrete emotions expressed during science activities in a unit on Energy. Multiple data sources including classroom videos, interviews and emotion diaries completed at the end of…

  10. Games and Word Activities.

    ERIC Educational Resources Information Center

    Northwest Regional Educational Lab., Portland, OR.

    Games and word activities give children another way to integrate their learning and reinforce their literacy skills. They provide different and enjoyable contexts in which children can apply what they are learning. This booklet offers activities which provide a sampling of "fun" ways for tutors to support and supplement their tutees' classroom…

  11. Active Healthy Summer

    ERIC Educational Resources Information Center

    Elliott, Eloise

    2005-01-01

    Summer break is almost here for most elementary teachers and students. Warmer weather and additional free time to make choices create more opportunities to be physically active, whether home alone or out with friends and family. This article describes ways by which physical education specialists can encourage students' physical activity by…

  12. Coordinating Shared Activities

    NASA Technical Reports Server (NTRS)

    Clement, Bradley

    2004-01-01

    Shared Activity Coordination (ShAC) is a computer program for planning and scheduling the activities of an autonomous team of interacting spacecraft and exploratory robots. ShAC could also be adapted to such terrestrial uses as helping multiple factory managers work toward competing goals while sharing such common resources as floor space, raw materials, and transports. ShAC iteratively invokes the Continuous Activity Scheduling Planning Execution and Replanning (CASPER) program to replan and propagate changes to other planning programs in an effort to resolve conflicts. A domain-expert specifies which activities and parameters thereof are shared and reports the expected conditions and effects of these activities on the environment. By specifying these conditions and effects differently for each planning program, the domain-expert subprogram defines roles that each spacecraft plays in a coordinated activity. The domain-expert subprogram also specifies which planning program has scheduling control over each shared activity. ShAC enables sharing of information, consensus over the scheduling of collaborative activities, and distributed conflict resolution. As the other planning programs incorporate new goals and alter their schedules in the changing environment, ShAC continually coordinates to respond to unexpected events.

  13. Reflections on Activity Theory

    ERIC Educational Resources Information Center

    Bakhurst, David

    2009-01-01

    It is sometimes suggested that activity theory represents the most important legacy of Soviet philosophy and psychology. But what exactly "is" activity theory? The canonical account in the West is given by Engestrom, who identifies three stages in the theory's development: from Vygotsky's insights, through Leontiev's articulation of the…

  14. Obesity, Physical Activity - Children.

    ERIC Educational Resources Information Center

    Gilliam, Thomas B.

    Childhood obesity starts at a very early age, and preventive measures taken early enough may retard the development of fat cells. It appears that physical activity plays an important role in reducing obesity. The activity program must start early, in preschool days. It is felt that screening children for obesity when they first enter school and…

  15. Science World Activities Book.

    ERIC Educational Resources Information Center

    Wisconsin Academy of Sciences, Arts and Letters, Madison.

    This document consists of three sections. Section I contains 19 activities developed by master teachers for the Science World '84 summer science program. These activities focus on studies involving airplane controls, trash bag kites, computers, meteorology, compass orienteering, soils, aquatic ecosystems, bogs, and others. Objectives, materials…

  16. Peak Longevity Physical Activity

    Cancer.gov

    People who engage in three to five times the recommended minimum level of leisure-time physical activity derive the greatest benefit in terms of mortality reduction when compared with people who do not engage in leisure-time physical activity.

  17. ZOOMsci Activity Guide.

    ERIC Educational Resources Information Center

    Wade, Meredith

    This activity guide is based on the Public Broadcasting System's (PBS) program "ZOOM." It is designed for educators with activities that are categorized into three themes: (1) Things That Go, which includes "Air" which explores air pressure, "Rubber Bands" which discovers the potential energy of rubber bands, "Baking Soda and Vinegar" which…

  18. Active galactic nuclei

    PubMed Central

    Fabian, Andrew C.

    1999-01-01

    Active galactic nuclei are the most powerful, long-lived objects in the Universe. Recent data confirm the theoretical idea that the power source is accretion into a massive black hole. The common occurrence of obscuration and outflows probably means that the contribution of active galactic nuclei to the power density of the Universe has been generally underestimated. PMID:10220363

  19. Activation of fly ash

    DOEpatents

    Corbin, D.R.; Velenyi, L.J.; Pepera, M.A.; Dolhyj, S.R.

    1986-08-19

    Fly ash is activated by heating a screened magnetic fraction of the ash in a steam atmosphere and then reducing, oxidizing and again reducing the hydrothermally treated fraction. The activated fly ash can be used as a carbon monoxide disproportionating catalyst useful in the production of hydrogen and methane.

  20. Laboratory Activities in Israel

    ERIC Educational Resources Information Center

    Mamlok-Naaman, Rachel; Barnea, Nitza

    2012-01-01

    Laboratory activities have long had a distinctive and central role in the science curriculum, and science educators have suggested that many benefits accrue from engaging students in science laboratory activities. Many research studies have been conducted to investigate the educational effectiveness of laboratory work in science education in…

  1. Curriculum Activities on Aging.

    ERIC Educational Resources Information Center

    Schmall, Vicki L.; Benge, Nancy

    This paper contains learning activities on aging for use with elementary, high school, and university students in health, family relationships, social studies, and art courses. The activities are intended to help youth develop a more realistic understanding of the aging process and to become aware of both the problems and benefits associated with…

  2. Nutrition Activities Resource Guide.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Special Education.

    The resource guide suggests activities to help special education students make appropriate choices about their nutritional habits. It is explained that the activities can be infused into other curriculum areas. The guide consists of five themes and includes performance objectives for each: foods eaten at school (planning a school lunch, keeping a…

  3. Activation of fly ash

    DOEpatents

    Corbin, David R.; Velenyi, Louis J.; Pepera, Marc A.; Dolhyj, Serge R.

    1986-01-01

    Fly ash is activated by heating a screened magnetic fraction of the ash in a steam atmosphere and then reducing, oxidizing and again reducing the hydrothermally treated fraction. The activated fly ash can be used as a carbon monoxide disproportionating catalyst useful in the production of hydrogen and methane.

  4. Learning Activities for Toddlers.

    ERIC Educational Resources Information Center

    Texas Child Care, 1996

    1996-01-01

    Suggests activities to help toddlers develop skills in the four important areas of self-help, creativity, world mastery, and coordination. Activities include hand washing, button practice, painting, movement and music, bubble making, creation of a nature mural, and a shoe print trail. (TJQ)

  5. Active and Healthy Schools

    ERIC Educational Resources Information Center

    Ball, Stephen; Kovarik, Jessica; Leidy, Heather

    2015-01-01

    The Active and Healthy School Program (AHS) can be used to alter the culture and environment of a school to help children make healthier choices. The purpose of this study was to determine the effectiveness of AHS to increase physical activity while decreasing total screen time, increase healthy food choices, and improve knowledge about physical…

  6. Calculator-Active Materials.

    ERIC Educational Resources Information Center

    Crow, Tracy, Ed.; Harris, Julia, Ed.

    1997-01-01

    This journal contains brief descriptions of calculator-active materials that were found using Resource Finder, the searchable online catalog of curriculum resources from the Eisenhower National Clearinghouse (ENC). It features both the calculators themselves and the activity books that are used with them. Among the calculators included are those…

  7. Activating Event Knowledge

    ERIC Educational Resources Information Center

    Hare, Mary; Jones, Michael; Thomson, Caroline; Kelly, Sarah; McRae, Ken

    2009-01-01

    An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or…

  8. Bonus Activity Book. Peacemakers.

    ERIC Educational Resources Information Center

    Whitman, Betsy Blizard

    1992-01-01

    Activity book helps elementary students learn about peace and see themselves as peacemakers and peacekeepers. Students are introduced to literary and historical figures who have worked for peace and won the Nobel Peace Prize. Activities teach students that peace means more than calm situations or absence of war. (SM)

  9. Vegetable Soup Activities.

    ERIC Educational Resources Information Center

    Shepard, Mary; Shepard, Ray

    Vegetable Soup is a new children's television series whose purpose is to counter the negative and destructive effects of racial isolation. This manual gives detailed instructions for discussion of activities that are presented during the television series such as: crafts, games, recipes, language activities, and children's questions. A list of…

  10. Student Activities. Managing Liability.

    ERIC Educational Resources Information Center

    Bennett, Barbara; And Others

    This monograph suggests ways that college or university administrations can undertake a systematic and careful review of the risks posed by students' activities. Its purpose is to provide guidance in integrating the risk management process into a school's existing approaches to managing student organizations and activities. It is noted that no…

  11. Untangling occupation and activity.

    PubMed

    Pierce, D

    2001-01-01

    Activity and occupation are two core concepts of occupational therapy that are in need of differentiation. Occupation is defined here as a person's personally constructed, one-time experience within a unique context. Activity is defined as a more general, culturally shared idea about a category of action. The ways in which subjectivity and context are handled within the concepts of occupation and activity are keys to disentangling them. The proposed untangling of the two concepts into distinct definitions is congruent with their historical origins as well as with current definitional trends. Once occupation and activity are recognized as two separate and equally valuable concepts, they offer a rich set of theoretical relations for exploration. The clarity that will result from differentiating occupation and activity will enhance disciplinary discourse and research as well as enhance the intervention efficacy, moral surety, and political strength of the profession.

  12. Active element pattern

    NASA Astrophysics Data System (ADS)

    Pozar, D. M.

    1994-08-01

    This review article will discuss the use of the active element pattern for prediction of the scan performance of large phased array antennas. The introduction and application of the concept of the active element pattern goes back at least 30 years (1) -(6) , but the subject is generally not covered in modern antenna engineering textbooks or handbooks, and many contemporary workers are unfamiliar with this simple but powerful idea. In addition, early references on this subject do not provide a rigorous discussion or derivation of the active element pattern, relying instead on a more qualitative interpretation. The purpose of this communication is to make the technique of active element patterns more accessible to antenna engineers, and to provide a new derivation of the basic active element pattern relations in terms of scattering parameters.

  13. Photocatalytic activity of transition-metal-ion-doped coordination polymer (CP): photoresponse region extension and quantum yields enhancement via doping of transition metal ions into the framework of CPs.

    PubMed

    Xu, Xin-Xin; Cui, Zhong-Ping; Gao, Xin; Liu, Xiao-Xia

    2014-06-21

    To improve photocatalytic activity of a coordination polymer (CP) in the visible light region, five different transition metal ions (Fe(3+), Cr(3+), Ru(3+), Co(2+) and Ni(2+)) were introduced into its framework through an ion-exchange process. Among all the resulting transition metal ion doped coordination polymers (TMI/CPs), the one doped with Fe(3+) took on the most excellent photocatalytic activity and the highest quantum yields in the visible light region, decomposing 94% Rhodamine B (RhB) in 8 hours. It can be attributed to the doping of Fe(3+), which reduced the band gap (Eg) of the original CP, facilitating photocatalysis of the obtained polymer. Compared with the coordination polymer with Fe(3+) as a dopant, products doped with other metal ions presented weaker photocatalytic activities in the visible light region, while under the irradiation of ultraviolet light, they showed favorable photocatalytic properties. The results suggest that to dope transition metal ions into the framework of CPs would be an ideal option for enhancing the photocatalytic activity of coordination polymers.

  14. Gastrocnemius and soleus are selectively activated when adding knee extensor activity to plantar flexion.

    PubMed

    Suzuki, Takahito; Chino, Kentaro; Fukashiro, Senshi

    2014-08-01

    The gastrocnemius is a biarticular muscle that acts not only as a plantar flexor, but also as a knee flexor, meaning that it is an antagonist during knee extension. In contrast, the soleus is a monoarticular plantar flexor. Based on this anatomical difference, these muscles' activities should be selectively activated during simultaneous plantar flexion and knee extension, which occur during many activities of daily living. This study examined the selective activation of gastrocnemius and soleus activities when voluntary isometric activation of knee extensors was added to voluntary isometric plantar flexion. Ten male volunteers performed isometric plantar flexion at 10%, 20%, and 30% of maximum effort. During each plantar flexion task, isometric knee extension was added at 0%, 50%, and 100% of maximum effort. When knee extension was added, the average rectified value of the electromyographic activity of the medial gastrocnemius was significantly depressed (P=.002), whereas that of the soleus was significantly increased (P<.001) regardless of the plantar flexion level. These results suggest that plantar flexion with concurrent knee extensor activity leads to selective activation of the soleus and depression of the synergistic activity of the gastrocnemius.

  15. Active optical zoom system

    DOEpatents

    Wick, David V.

    2005-12-20

    An active optical zoom system changes the magnification (or effective focal length) of an optical imaging system by utilizing two or more active optics in a conventional optical system. The system can create relatively large changes in system magnification with very small changes in the focal lengths of individual active elements by leveraging the optical power of the conventional optical elements (e.g., passive lenses and mirrors) surrounding the active optics. The active optics serve primarily as variable focal-length lenses or mirrors, although adding other aberrations enables increased utility. The active optics can either be LC SLMs, used in a transmissive optical zoom system, or DMs, used in a reflective optical zoom system. By appropriately designing the optical system, the variable focal-length lenses or mirrors can provide the flexibility necessary to change the overall system focal length (i.e., effective focal length), and therefore magnification, that is normally accomplished with mechanical motion in conventional zoom lenses. The active optics can provide additional flexibility by allowing magnification to occur anywhere within the FOV of the system, not just on-axis as in a conventional system.

  16. Emotionally Intense Science Activities

    NASA Astrophysics Data System (ADS)

    King, Donna; Ritchie, Stephen; Sandhu, Maryam; Henderson, Senka

    2015-08-01

    Science activities that evoke positive emotional responses make a difference to students' emotional experience of science. In this study, we explored 8th Grade students' discrete emotions expressed during science activities in a unit on Energy. Multiple data sources including classroom videos, interviews and emotion diaries completed at the end of each lesson were analysed to identify individual student's emotions. Results from two representative students are presented as case studies. Using a theoretical perspective drawn from theories of emotions founded in sociology, two assertions emerged. First, during the demonstration activity, students experienced the emotions of wonder and surprise; second, during a laboratory activity, students experienced the intense positive emotions of happiness/joy. Characteristics of these activities that contributed to students' positive experiences are highlighted. The study found that choosing activities that evoked strong positive emotional experiences, focused students' attention on the phenomenon they were learning, and the activities were recalled positively. Furthermore, such positive experiences may contribute to students' interest and engagement in science and longer term memorability. Finally, implications for science teachers and pre-service teacher education are suggested.

  17. Active touch sensing

    PubMed Central

    Prescott, Tony J.; Diamond, Mathew E.; Wing, Alan M.

    2011-01-01

    Active sensing systems are purposive and information-seeking sensory systems. Active sensing usually entails sensor movement, but more fundamentally, it involves control of the sensor apparatus, in whatever manner best suits the task, so as to maximize information gain. In animals, active sensing is perhaps most evident in the modality of touch. In this theme issue, we look at active touch across a broad range of species from insects, terrestrial and marine mammals, through to humans. In addition to analysing natural touch, we also consider how engineering is beginning to exploit physical analogues of these biological systems so as to endow robots with rich tactile sensing capabilities. The different contributions show not only the varieties of active touch—antennae, whiskers and fingertips—but also their commonalities. They explore how active touch sensing has evolved in different animal lineages, how it serves to provide rapid and reliable cues for controlling ongoing behaviour, and even how it can disintegrate when our brains begin to fail. They demonstrate that research on active touch offers a means both to understand this essential and primary sensory modality, and to investigate how animals, including man, combine movement with sensing so as to make sense of, and act effectively in, the world. PMID:21969680

  18. Biological activity of purpurogallin.

    PubMed

    Inamori, Y; Muro, C; Sajima, E; Katagiri, M; Okamoto, Y; Tanaka, H; Sakagami, Y; Tsujibo, H

    1997-05-01

    Purpurogallin showed antibacterial activity toward gram-positive bacteria. Strong activity against methicillin-resistant Staphylococcus aureus [minimal inhibitory concentration (MIC) against methicillin of 1600 micrograms/ml] was found, with MIC of 11.0 micrograms/ml. Purpurogallin inhibited the growth of all tested plants and decreased the chlorophyll content in the cotyledons of Brassica campestris subsp. rapa. It showed potent inhibitory activity against prolyl endopeptidase (the 50% inhibitory concentration was 1.6 x 10(-5) M), unlike its analogues, hinokitiol and tropolone.

  19. Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.

    PubMed

    Hou, De-Xing; Kai, Keiko; Li, Jian-Jian; Lin, Shigang; Terahara, Norihiko; Wakamatsu, Mika; Fujii, Makoto; Young, Mattew R; Colburn, Nancy

    2004-01-01

    Anthocyanins are the chemical components that give the intense color to many fruits and vegetables, such as blueberries, red cabbages and purple sweet potatoes. Extensive studies have indicated that anthocyanins have strong antioxidant activities. To investigate the mechanism of anthocyanidins as an anticancer food source, six kinds of anthocyanidins representing the aglycons of most anthocyanins, were used to examine their effects on tumor promotion in mouse JB6 cells, a validated model for screening cancer chemopreventive agents and elucidating the molecular mechanisms. Of the six anthocyanins tested, only those with an ortho-dihydroxyphenyl structure on the B-ring suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation and activator protein-1 transactivation, suggesting that the ortho-dihydroxyphenyl may contribute to the inhibitory action. Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times. p38 kinase was not inhibited by delphinidin. Furthermore, two mitogen-activated protein kinase (MAPK) specific inhibitors (SP600125 for JNK and UO126 for ERK) could specifically block the activation of JNK and ERK and cell transformation. Those results demonstrate that anthocyanidins contribute to the inhibition of tumorigenesis by blocking activation of the MAPK pathway. These findings provide the first molecular basis for the anticarcinogenic action of anthocyanidins. PMID:14514663

  20. Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.

    PubMed

    Hou, De-Xing; Kai, Keiko; Li, Jian-Jian; Lin, Shigang; Terahara, Norihiko; Wakamatsu, Mika; Fujii, Makoto; Young, Mattew R; Colburn, Nancy

    2004-01-01

    Anthocyanins are the chemical components that give the intense color to many fruits and vegetables, such as blueberries, red cabbages and purple sweet potatoes. Extensive studies have indicated that anthocyanins have strong antioxidant activities. To investigate the mechanism of anthocyanidins as an anticancer food source, six kinds of anthocyanidins representing the aglycons of most anthocyanins, were used to examine their effects on tumor promotion in mouse JB6 cells, a validated model for screening cancer chemopreventive agents and elucidating the molecular mechanisms. Of the six anthocyanins tested, only those with an ortho-dihydroxyphenyl structure on the B-ring suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation and activator protein-1 transactivation, suggesting that the ortho-dihydroxyphenyl may contribute to the inhibitory action. Delphinidin, but not peonidin, blocked the phosphorylation of protein kinases in the extracellular signal-regulated protein kinase (ERK) pathway at early times and the c-Jun N-terminal kinase (JNK) signaling pathway at later times. p38 kinase was not inhibited by delphinidin. Furthermore, two mitogen-activated protein kinase (MAPK) specific inhibitors (SP600125 for JNK and UO126 for ERK) could specifically block the activation of JNK and ERK and cell transformation. Those results demonstrate that anthocyanidins contribute to the inhibition of tumorigenesis by blocking activation of the MAPK pathway. These findings provide the first molecular basis for the anticarcinogenic action of anthocyanidins.

  1. Standardizing Activation Analysis: New Software for Photon Activation Analysis

    SciTech Connect

    Sun, Z. J.; Wells, D.; Green, J.; Segebade, C.

    2011-06-01

    Photon Activation Analysis (PAA) of environmental, archaeological and industrial samples requires extensive data analysis that is susceptible to error. For the purpose of saving time, manpower and minimizing error, a computer program was designed, built and implemented using SQL, Access 2007 and asp.net technology to automate this process. Based on the peak information of the spectrum and assisted by its PAA library, the program automatically identifies elements in the samples and calculates their concentrations and respective uncertainties. The software also could be operated in browser/server mode, which gives the possibility to use it anywhere the internet is accessible. By switching the nuclide library and the related formula behind, the new software can be easily expanded to neutron activation analysis (NAA), charged particle activation analysis (CPAA) or proton-induced X-ray emission (PIXE). Implementation of this would standardize the analysis of nuclear activation data. Results from this software were compared to standard PAA analysis with excellent agreement. With minimum input from the user, the software has proven to be fast, user-friendly and reliable.

  2. Algorithm-development activities

    NASA Technical Reports Server (NTRS)

    Carder, Kendall L.

    1994-01-01

    The task of algorithm-development activities at USF continues. The algorithm for determining chlorophyll alpha concentration, (Chl alpha) and gelbstoff absorption coefficient for SeaWiFS and MODIS-N radiance data is our current priority.

  3. Microglial Activation & Chronic Neurodegeneration

    PubMed Central

    Lull, Melinda E.; Block, Michelle L.

    2010-01-01

    Microglia, the resident innate immune cells in the brain, have long been implicated in the pathology of neurodegenerative diseases. Accumulating evidence points to activated microglia as a chronic source of multiple neurotoxic factors, including TNFα, NO, IL1-β, and reactive oxygen species (ROS), driving progressive neuron damage. Microglia can become chronically activated by either a single stimulus (ex. LPS or neuron damage) or multiple stimuli exposures to result in cumulative neuronal loss over time. While the mechanisms driving these phenomena are just beginning to be understood, reactive microgliosis (the microglial response to neuron damage) and ROS have been implicated as key mechanisms of chronic and neurotoxic microglial activation, particularly in the case of Parkinson’s Disease. Here, we review the mechanisms of neurotoxicity associated with chronic microglial activation and discuss the role of neuronal death and microglial ROS driving the chronic and toxic microglial phenotype. PMID:20880500

  4. Active noise reduction

    NASA Astrophysics Data System (ADS)

    Carter, J.

    1984-01-01

    Active Noise Reduction (ANR) techniques, singly and in combination with passive hearing protectors, offer the potential for increased sound protection, enhanced voice communications and improved wearability features for personnel exposed to unacceptable noise conditions. An enhanced closed loop active noise reduction system was miniaturized and incorporated into a standard Air Force flight helmet (HGU-26/P). This report describes the theory of design and operation, prototype configuration and operation, and electroacoustic performance and specifications for the ANR system. This system is theoretically capable of producing in excess of 30 decibels of active noise reduction. Electroacoustic measurements on a flat plate coupler demonstrated approximately 20 decibels of active noise reduction with the prototype unit. A performance evaluation of the integrated ANR unit will be conducted under laboratory and field conditions by government personnel to determine the feasibility of the system for use in military applications.

  5. Activities in Teaching Weather

    ERIC Educational Resources Information Center

    Tonn, Martin

    1977-01-01

    Presented is a unit composed of activities for teaching weather. Topics include cloud types and formation, simple weather instruments, and the weather station. Illustrations include a weather chart and instruments. A bibliography is given. (MA)

  6. Island Watershed Activity.

    ERIC Educational Resources Information Center

    Benson, Rod

    2003-01-01

    Describes a 90-minute "Island Watershed" activity to help earth science students understand the concept of the water cycle. Introduces a surface waters unit appropriate for students in grades 7-10. Includes watershed project guidelines. (Author/KHR)

  7. Authentic Listening Activities.

    ERIC Educational Resources Information Center

    Porter, Don; Roberts, Jon

    1981-01-01

    Discusses use of authentic listening experiences in second language classroom so that students will become involved in listening process demanded in authentic listening situations. Gives examples of sample classroom activities. (BK)

  8. French space activities

    NASA Technical Reports Server (NTRS)

    Blanc, R.

    1982-01-01

    The four main points of research and development of space programs by France are explained. The National Center of Space Studies is discussed, listing the missions of the Center and describing the activities of the staff.

  9. Creating Art Appreciation Activities.

    ERIC Educational Resources Information Center

    Heidt, Ann H.

    1986-01-01

    The experiences of college students enrolled as majors in elementary education in designing art appreciation activities for use in elementary classrooms are described. The college students had no art background. (RM)

  10. Active terahertz metamaterials

    SciTech Connect

    Chen, Hou-tong

    2009-01-01

    We demonstrate planar terahertz metamaterial devices enabling actively controllable transmission amplitude, phase, or frequency at room temperature via carrier depletion or photoexcitation in the semiconductor substrate or in semiconductor materials incorporated into the metamaterial structure.

  11. Planning activities in space

    NASA Technical Reports Server (NTRS)

    Chang, Kai-Hsiung

    1987-01-01

    Three aspects of planning activities in space are presented. These include generating plans efficiently, coordinating actions among multiple agents, and recovering from plan execution errors. Each aspect is discussed separately.

  12. A Big Gulp Activity.

    ERIC Educational Resources Information Center

    Kelly, Bruce

    1997-01-01

    Explains how to implement an activity in which students measure the volume of their oral cavities. Enables students to develop skills in estimation, measurement, connections, statistics, applying concepts and procedures, and communication. (DDR)

  13. PRESSURE ACTIVATED SEALANT TECHNOLOGY

    SciTech Connect

    Michael A. Romano

    2004-04-01

    The objective of this project is to develop new, efficient, cost effective methods of internally sealing natural gas pipeline leaks through the application of differential pressure activated sealants. In researching the current state of the art for gas pipeline sealing technologies we concluded that if the project was successful, it appeared that pressure activated sealant technology would provide a cost effective alternative to existing pipeline repair technology. From our analysis of current field data for a 13 year period from 1985 to 1997 we were able to identify 205 leaks that were candidates for pressure activated sealant technology, affirming that pressure activated sealant technology is a viable option to traditional external leak repairs. The data collected included types of defects, areas of defects, pipe sizes and materials, incident and operating pressures, ability of pipeline to be pigged and corrosion states. This data, and subsequent analysis, was utilized as a basis for constructing applicable sealant test modeling.

  14. Intercreativity: Mapping Online Activism

    NASA Astrophysics Data System (ADS)

    Meikle, Graham

    How do activists use the Internet? This article maps a wide range of activist practice and research by applying and developing Tim Berners-Lee's concept of ‘intercreativity' (1999). It identifies four dimensions of Net activism: intercreative texts, tactics, strategies and networks. It develops these through examples of manifestations of Net activism around one cluster of issues: support campaigns for refugees and asylum seekers.

  15. RMS active damping augmentation

    NASA Technical Reports Server (NTRS)

    Gilbert, Michael G.; Scott, Michael A.; Demeo, Martha E.

    1992-01-01

    The topics are presented in viewgraph form and include: RMS active damping augmentation; potential space station assembly benefits to CSI; LaRC/JSC bridge program; control law design process; draper RMS simulator; MIMO acceleration control laws improve damping; potential load reduction benefit; DRS modified to model distributed accelerations; accelerometer location; Space Shuttle aft cockpit simulator; simulated shuttle video displays; SES test goals and objectives; and SES modifications to support RMS active damping augmentation.

  16. Information Activities in Australia

    NASA Astrophysics Data System (ADS)

    Hanada, Takeyoshi

    The last few years have seen an explosive growth in database and computer networking activities in Australia. At present there are six major information networks in Australia, which carry more than 400 locally produced databases and many others from overseas. AUSINET databases are exemplified. MIDAS (Multi-mode International Data Aquisition System) provides lower cost access to overseas databases than before. The paper also gives brief outline of various bodies which relate to information and library policy in Australia and regional cooperative activities.

  17. RAVEN Quality Assurance Activities

    SciTech Connect

    Cogliati, Joshua Joseph

    2015-09-01

    This report discusses the quality assurance activities needed to raise the Quality Level of Risk Analysis in a Virtual Environment (RAVEN) from Quality Level 3 to Quality Level 2. This report also describes the general RAVEN quality assurance activities. For improving the quality, reviews of code changes have been instituted, more parts of testing have been automated, and improved packaging has been created. For upgrading the quality level, requirements have been created and the workflow has been improved.

  18. Low activation ferritic alloys

    DOEpatents

    Gelles, David S.; Ghoniem, Nasr M.; Powell, Roger W.

    1986-01-01

    Low activation ferritic alloys, specifically bainitic and martensitic stainless steels, are described for use in the production of structural components for nuclear fusion reactors. They are designed specifically to achieve low activation characteristics suitable for efficient waste disposal. The alloys essentially exclude molybdenum, nickel, nitrogen and niobium. Strength is achieved by substituting vanadium, tungsten, and/or tantalum in place of the usual molybdenum content in such alloys.

  19. Low activation ferritic alloys

    DOEpatents

    Gelles, D.S.; Ghoniem, N.M.; Powell, R.W.

    1985-02-07

    Low activation ferritic alloys, specifically bainitic and martensitic stainless steels, are described for use in the production of structural components for nuclear fusion reactors. They are designed specifically to achieve low activation characteristics suitable for efficient waste disposal. The alloys essentially exclude molybdenum, nickel, nitrogen and niobium. Strength is achieved by substituting vanadium, tungsten, and/or tantalum in place of the usual molybdenum content in such alloys.

  20. Tinnitus activities treatment.

    PubMed

    Tyler, Richard S; Gogel, Stephanie A; Gehringer, Anne K

    2007-01-01

    Tinnitus Activities Treatment includes counseling of the whole person, and considers individual differences and needs. We consider four areas: thoughts and emotions, hearing and communication, sleep, and concentration. We typically use Partial Masking Sound Therapy, with a noise or music set to the lowest level that provides relief. A picture-based approach facilitates engagement of the patient, and provides thorough and structured counseling. We engage the patient by including homework and activities to demonstrate understanding and facilitate progress. PMID:17956807

  1. Phytase activity in lichens.

    PubMed

    Higgins, Niall F; Crittenden, Peter D

    2015-10-01

    Phytase activity was investigated in 13 lichen species using a novel assay method. The work tested the hypothesis that phytase is a component of the suite of surface-bound lichen enzymes that hydrolyse simple organic forms of phosphorus (P) and nitrogen (N) deposited onto the thallus surface. Hydrolysis of inositol hexaphosphate (InsP6 , the substrate for phytase) and appearance of lower-order inositol phosphates (InsP5 -InsP1 ), the hydrolysis products, were measured by ion chromatography. Phytase activity in Evernia prunastri was compared among locations with contrasting rates of N deposition. Phytase activity was readily measurable in epiphytic lichens (e.g. 11.3 μmol InsP6 hydrolysed g(-1)  h(-1) in Bryoria fuscescens) but low in two terricolous species tested (Cladonia portentosa and Peltigera membranacea). Phytase and phosphomonoesterase activities were positively correlated amongst species. In E. prunastri both enzyme activities were promoted by N enrichment and phytase activity was readily released into thallus washings. InsP6 was not detected in tree canopy throughfall but was present in pollen leachate. Capacity to hydrolyse InsP6 appears widespread amongst lichens potentially promoting P capture from atmospheric deposits and plant leachates, and P cycling in forest canopies. The enzyme assay used here might find wider application in studies on plant root-fungal-soil systems.

  2. Physical activity and obesity.

    PubMed

    Tremblay, A

    1999-04-01

    The regular practice of physical activity promotes metabolic adaptations that facilitate the regulation of energy and fat balance. These effects are important for a better control of body weight in the obese individual and should enable him or her to involve adipose tissue to a lesser extent in this regulation. Physical activity favours a negative energy and fat balance, particularly if activities are prolonged and vigorous. The achievement of a negative energy and fat balance with physical activity also strongly depends on the nutritional context in which it is performed. In the long term, an active lifestyle and low-fat food habits are expected to induce a substantial body weight loss in the obese. This weight loss is progressively attenuated over time, presumably because of the decreased impact of a reduced adipose tissue mass on the regulation of energy and fat balance. For the obese individual complying with an activity programme and healthy food habits, a body weight loss of 10% is a realistic goal before the occurrence of resistance to further loss of body fat.

  3. ABB: active bandwidth broker

    NASA Astrophysics Data System (ADS)

    Wong, Kason; Law, Eddie

    2001-07-01

    In this paper, we shall discuss a novel design on the policy-based management for the Internet. This design deploys the concept of active networking. As opposed to the traditional network design, active network empowers network node with the ability to manipulate data and program code in packets, and configure the network properties according to the needs of different applications. The policy-based management can control network routers in order to realize end-to-end Quality of Service (QoS), such as differentiated and integrated services, across the Internet. For the moment, the Internet Engineering Task Force (IETF) has defined the framework of the policy-based management. It employs a simple client/server model that uses Common Open Policy Service (COPS) protocol to facilitate policy management and control. Our design of Active Bandwidth Broker (ABB) belongs to an active application. Our goals are to distribute centralized workload of the policy-based management over multiple active nodes in the active networks, introduce mobility of the bandwidth brokers, and allows load sharing to the policy-based management. This results a network-wide intelligent, highly available, and consistent QoS control that allows performance protection for voice, video and Internet business application while reducing costs for growing networks.

  4. Anticancer activity of Amauroderma rude.

    PubMed

    Jiao, Chunwei; Xie, Yi-Zhen; Yang, Xiangling; Li, Haoran; Li, Xiang-Min; Pan, Hong-Hui; Cai, Mian-Hua; Zhong, Hua-Mei; Yang, Burton B

    2013-01-01

    More and more medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients. Here we report screening thirteen mushrooms for anti-cancer cell activities in eleven different cell lines. Of the herbal products tested, we found that the extract of Amauroderma rude exerted the highest activity in killing most of these cancer cell lines. Amauroderma rude is a fungus belonging to the Ganodermataceae family. The Amauroderma genus contains approximately 30 species widespread throughout the tropical areas. Since the biological function of Amauroderma rude is unknown, we examined its anti-cancer effect on breast carcinoma cell lines. We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucidum. We then examined the effect of Amauroderma rude on breast cancer cells and found that at low concentrations, Amauroderma rude could inhibit cancer cell survival and induce apoptosis. Treated cancer cells also formed fewer and smaller colonies than the untreated cells. When nude mice bearing tumors were injected with Amauroderma rude extract, the tumors grew at a slower rate than the control. Examination of these tumors revealed extensive cell death, decreased proliferation rate as stained by Ki67, and increased apoptosis as stained by TUNEL. Suppression of c-myc expression appeared to be associated with these effects. Taken together, Amauroderma rude represented a powerful medicinal mushroom with anti-cancer activities. PMID:23840494

  5. Anticancer Activity of Amauroderma rude

    PubMed Central

    Yang, Xiangling; Li, Haoran; Li, Xiang-Min; Pan, Hong-Hui; Cai, Mian-Hua; Zhong, Hua-Mei; Yang, Burton B.

    2013-01-01

    More and more medicinal mushrooms have been widely used as a miraculous herb for health promotion, especially by cancer patients. Here we report screening thirteen mushrooms for anti-cancer cell activities in eleven different cell lines. Of the herbal products tested, we found that the extract of Amauroderma rude exerted the highest activity in killing most of these cancer cell lines. Amauroderma rude is a fungus belonging to the Ganodermataceae family. The Amauroderma genus contains approximately 30 species widespread throughout the tropical areas. Since the biological function of Amauroderma rude is unknown, we examined its anti-cancer effect on breast carcinoma cell lines. We compared the anti-cancer activity of Amauroderma rude and Ganoderma lucidum, the most well-known medicinal mushrooms with anti-cancer activity and found that Amauroderma rude had significantly higher activity in killing cancer cells than Ganoderma lucidum. We then examined the effect of Amauroderma rude on breast cancer cells and found that at low concentrations, Amauroderma rude could inhibit cancer cell survival and induce apoptosis. Treated cancer cells also formed fewer and smaller colonies than the untreated cells. When nude mice bearing tumors were injected with Amauroderma rude extract, the tumors grew at a slower rate than the control. Examination of these tumors revealed extensive cell death, decreased proliferation rate as stained by Ki67, and increased apoptosis as stained by TUNEL. Suppression of c-myc expression appeared to be associated with these effects. Taken together, Amauroderma rude represented a powerful medicinal mushroom with anti-cancer activities. PMID:23840494

  6. Antimutagenic activity of spearmint.

    PubMed

    Yu, Tian-Wei; Xu, Meirong; Dashwood, Roderick H

    2004-01-01

    The antimutagenic activity of spearmint (Mentha spicata), a popular food flavoring agent, was studied in the Salmonella assay. Spearmint leaves were brewed in hot water for 5 min at concentrations up to 5% (w/v), and the water extracts were tested against the direct-acting mutagens 4-nitro-1,2-phenylenediamine (NPD) and 2-hydroxyamino-3-methyl-3H-imidazo[4,5-f]quinoline (N-OH-IQ) using Salmonella typhimurium strain TA98. Nontoxic concentrations of spearmint extract inhibited the mutagenic activity of N-OH-IQ in a concentration-dependent fashion, but had no effect against NPD. These experiments by design focused on the water extract consumed commonly as an herbal tea, but chloroform and methanol extracts of spearmint also possessed antimutagenic activity against N-OH-IQ. Water extract of spearmint inhibited the mutagenic activity of the parent compound, 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ), in the presence of rat liver S9; however, the concentration for 50% inhibition (IC50) against IQ was approximately 10-fold higher than in assays with N-OH-IQ minus S9. At concentrations similar to those used in the Salmonella assays, spearmint extract inhibited two of the major enzymes that play a role in the metabolic activation of IQ, namely, cytochromes P4501A1 and 1A2, based on ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase assays in vitro. In vivo, rats were given spearmint water extract (2%; w/v) as the sole source of drinking fluid before, during, and after 2-week treatment with IQ; colonic aberrant crypt foci were inhibited significantly at 8 weeks (P < 0.05, compared with rats given IQ alone). Collectively, these findings suggest that spearmint tea protects against IQ and possibly other heterocyclic amines through inhibition of carcinogen activation and via direct effects on the activated metabolite(s).

  7. Clinical efficacy, radiographic and safety findings through 5 years of subcutaneous golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of a randomised, placebo-controlled trial (the GO-REVEAL study)

    PubMed Central

    Kavanaugh, Arthur; McInnes, Iain B; Mease, Philip; Krueger, Gerald G; Gladman, Dafna; van der Heijde, Désirée; Zhou, Yiying; Lu, Jiandong; Leu, Jocelyn H; Goldstein, Neil; Beutler, Anna

    2014-01-01

    Objectives Assess golimumab's long-term efficacy/safety in psoriatic arthritis (PsA). Methods Adults with active PsA (≥3 swollen and tender joints, active psoriasis) were randomly assigned to subcutaneous placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks (q4wks) through wk20. All patients received golimumab 50 mg or 100 mg q4wks from wk24 forward. Methotrexate was allowed and taken by approximately half the patients. Findings through 5 years are reported herein. Efficacy assessments included ≥20% improvement in American College of Rheumatology (ACR20) response, C-reactive-protein-based, 28-joint-count Disease Activity Score (DAS28-CRP) response, ≥75% improvement in Psoriasis Area and Severity Index (PASI75) scores, and PsA-modified Sharp/van der Heijde scores (SHSs). Results 126/405 (31%) randomised patients discontinued treatment through wk252. Golimumab was effective in maintaining clinical improvement through year-5 (ACR20: 62.8–69.9%, DAS28-CRP: 75.2-84.9% for randomised patients; PASI75: 60.8–72.2% among randomised patients with ≥3% body surface area involvement) and inhibiting radiographic progression (mean changes in PsA-modified SHS: 0.1–0.3) among patients with radiographic data. While concomitant methotrexate did not affect ACR20/PASI75, it appeared to reduce radiographic progression. No new safety signals were identified. Antibodies-to-golimumab occurred in 1.8%/10.0% of patients with/without methotrexate). Conclusions Long-term golimumab safety/efficacy in PsA was demonstrated through 5 years. Trial registration number NCT00265096. PMID:24748630

  8. Both Sm-domain and C-terminal extension of Lsm1 are important for the RNA-binding activity of the Lsm1-7-Pat1 complex.

    PubMed

    Chowdhury, Ashis; Raju, Kalidindi K; Kalurupalle, Swathi; Tharun, Sundaresan

    2012-05-01

    Lsm proteins are a ubiquitous family of proteins characterized by the Sm-domain. They exist as hexa- or heptameric RNA-binding complexes and carry out RNA-related functions. The Sm-domain is thought to be sufficient for the RNA-binding activity of these proteins. The highly conserved eukaryotic Lsm1 through Lsm7 proteins are part of the cytoplasmic Lsm1-7-Pat1 complex, which is an activator of decapping in the conserved 5'-3' mRNA decay pathway. This complex also protects mRNA 3'-ends from trimming in vivo. Purified Lsm1-7-Pat1 complex is able to bind RNA in vitro and exhibits a unique binding preference for oligoadenylated RNA (over polyadenylated and unadenylated RNA). Lsm1 is a key subunit that determines the RNA-binding properties of this complex. The normal RNA-binding activity of this complex is crucial for mRNA decay and 3'-end protection in vivo and requires the intact Sm-domain of Lsm1. Here, we show that though necessary, the Sm-domain of Lsm1 is not sufficient for the normal RNA-binding ability of the Lsm1-7-Pat1 complex. Deletion of the C-terminal domain (CTD) of Lsm1 (while keeping the Sm-domain intact) impairs mRNA decay in vivo and results in Lsm1-7-Pat1 complexes that are severely impaired in RNA binding in vitro. Interestingly, the mRNA decay and 3'-end protection defects of such CTD-truncated lsm1 mutants could be suppressed in trans by overexpression of the CTD polypeptide. Thus, unlike most Sm-like proteins, Lsm1 uniquely requires both its Sm-domain and CTD for its normal RNA-binding function.

  9. Walkability and Physical Activity

    PubMed Central

    Reis, Rodrigo Siqueira; Hino, Adriano Akira Ferreira; Rech, Cassiano Ricardo; Kerr, Jacqueline; Hallal, Pedro Curi

    2013-01-01

    Background Evidence from developing countries is limited on how income level for a given neighborhood is related to physical activity among its residents. Purpose The goal of the study was to examine the association between walkability and physical activity outcomes, and the effect of income on the relationship between walkability and physical activity in adults. Methods The Spaces for Physical Activity in Adults Study (ESPACOS Project) took place in Curitiba, Brazil. Data were collected in 2010 in 32 census tracts selected to vary in income and walkability, as measured by GIS. Participants were 697 individuals aged 18–65 years (52.0% were women) randomly sampled from the selected neighborhoods. The International Physical Activity Questionnaire was used to measure physical activity. All analyses were conducted in 2012. Results The proportion of those who walked for transportation for ≥150 minutes/week was 21.1% in low-walkability areas, and ranged from 33.5% to 35.0% in high-walkability areas. A total of 12.6% of residents were found to walk for leisure for ≥150 minutes/week; this result did not vary across quadrants of walkability and income level. The prevalence of leisure-time moderate-to-vigorous physical activity (MVPA) was 7.1–10.5 percentage points higher in high-compared to low-walkability areas. After adjusting for all individual confounders, walkability showed an independent association with walking for transport (OR=2.10, 95% CI=1.31, 3.37, p=0.002) and leisure-time MVPA (OR=1.57; 95% CI=1.06, 2.32; p=0.024). Neighborhood income level was independently associated with leisure-time MVPA (OR=1.70; 95% CI=1.06, 2.74, p=0.029). No association was found between walkability and walking for leisure. No interaction was found between walkability and neighborhood income level. Conclusions This study, among adults living in Curitiba, Brazil, confirms findings from studies of high-income countries showing that walkability is positively associated with

  10. Mechanochemically Active Soft Robots.

    PubMed

    Gossweiler, Gregory R; Brown, Cameron L; Hewage, Gihan B; Sapiro-Gheiler, Eitan; Trautman, William J; Welshofer, Garrett W; Craig, Stephen L

    2015-10-14

    The functions of soft robotics are intimately tied to their form-channels and voids defined by an elastomeric superstructure that reversibly stores and releases mechanical energy to change shape, grip objects, and achieve complex motions. Here, we demonstrate that covalent polymer mechanochemistry provides a viable mechanism to convert the same mechanical potential energy used for actuation in soft robots into a mechanochromic, covalent chemical response. A bis-alkene functionalized spiropyran (SP) mechanophore is cured into a molded poly(dimethylsiloxane) (PDMS) soft robot walker and gripper. The stresses and strains necessary for SP activation are compatible with soft robot function. The color change associated with actuation suggests opportunities for not only new color changing or camouflaging strategies, but also the possibility for simultaneous activation of latent chemistry (e.g., release of small molecules, change in mechanical properties, activation of catalysts, etc.) in soft robots. In addition, mechanochromic stress mapping in a functional robotic device might provide a useful design and optimization tool, revealing spatial and temporal force evolution within the robot in a way that might be coupled to autonomous feedback loops that allow the robot to regulate its own activity. The demonstration motivates the simultaneous development of new combinations of mechanophores, materials, and soft, active devices for enhanced functionality.

  11. Photon-activation therapy

    SciTech Connect

    Fairchild, R.G.; Bond, V.P.

    1982-01-01

    Photon Activation Therapy (PAT) is a technique in which radiation dose to tumor is enhanced via introduction of stable /sup 127/I in the form of iodinated deoxyuridine (IdUrd). Stimulation of cytotoxic effects from IdUrd is accomplished by activation with external (or implanted) radiation sources. Thus, accumulations of this nucleoside in actively competing cellpools do not preclude therapy in so far as such tissues can be excluded from the radiation field. Calculations show that 5% replacement of thymidine (Tyd) in tumor DNA should enhance the biological effectiveness of a given photon radiotherapy dose by a factor of approx. 3. Proportionally higher gains would result from higher replacements of Tyd and IdUrd. In addition, biological response is enhanced by chemical sensitization with IdUrd. The data indicate that damage from photon activation as well as chemical sensitization does not repair. Thus, at low dose rates, a further increase in therapeutic gain should accrue as normal tissues are allowed to repair and regenerate. A samarium-145 source has been developed for PAT, with activating x-ray energies of from 38 to 45 keV. Favorable clinical results can be expected through the use of IdUrd and protracted irradiations with low energy x-rays. In particular, PAT may provide unique advantages at selected sites such as brain, or head and neck tumors. (ERB)

  12. Mechanochemically Active Soft Robots.

    PubMed

    Gossweiler, Gregory R; Brown, Cameron L; Hewage, Gihan B; Sapiro-Gheiler, Eitan; Trautman, William J; Welshofer, Garrett W; Craig, Stephen L

    2015-10-14

    The functions of soft robotics are intimately tied to their form-channels and voids defined by an elastomeric superstructure that reversibly stores and releases mechanical energy to change shape, grip objects, and achieve complex motions. Here, we demonstrate that covalent polymer mechanochemistry provides a viable mechanism to convert the same mechanical potential energy used for actuation in soft robots into a mechanochromic, covalent chemical response. A bis-alkene functionalized spiropyran (SP) mechanophore is cured into a molded poly(dimethylsiloxane) (PDMS) soft robot walker and gripper. The stresses and strains necessary for SP activation are compatible with soft robot function. The color change associated with actuation suggests opportunities for not only new color changing or camouflaging strategies, but also the possibility for simultaneous activation of latent chemistry (e.g., release of small molecules, change in mechanical properties, activation of catalysts, etc.) in soft robots. In addition, mechanochromic stress mapping in a functional robotic device might provide a useful design and optimization tool, revealing spatial and temporal force evolution within the robot in a way that might be coupled to autonomous feedback loops that allow the robot to regulate its own activity. The demonstration motivates the simultaneous development of new combinations of mechanophores, materials, and soft, active devices for enhanced functionality. PMID:26390078

  13. Prenucleosomes and Active Chromatin

    PubMed Central

    Khuong, Mai T.; Fei, Jia; Ishii, Haruhiko; Kadonaga, James T.

    2016-01-01

    Chromatin consists of nucleosomes as well as nonnucleosomal histone-containing particles. Here we describe the prenucleosome, which is a stable conformational isomer of the nucleosome that associates with ~80 bp DNA. Prenucleosomes are formed rapidly upon the deposition of histones onto DNA and can be converted into canonical nucleosomes by an ATP-driven chromatin assembly factor such as ACF. Different lines of evidence reveal that there are prenucleosome-sized DNA-containing particles with histones in the upstream region of active promoters. Moreover, p300 acetylates histone H3K56 in prenucleosomes but not in nucleosomes, and H3K56 acetylation is found at active promoters and enhancers. These findings therefore suggest that there may be prenucleosomes or prenucleosome-like particles in the upstream region of active promoters. More generally, we postulate that prenucleosomes or prenucleosome-like particles are present at dynamic chromatin, whereas canonical nucleosomes are at static chromatin. PMID:26767995

  14. [Physical activity and obesity].

    PubMed

    Winkler, S; Hebestreit, A; Ahrens, W

    2012-01-01

    One reason for the high prevalence of overweight and obesity might be the differences in lifestyle compared to earlier decades, called the "obesogenic environment." With this, the decline in physical activity (PA) in favor of a sedentary lifestyle is assumed to play an important role. Physical activity or inactivity has a major impact on the development of overweight and obesity as well as on certain metabolic disorders. This review summarizes current scientific knowledge regarding the association between PA and overweight/obesity. The term "physical activity" is defined and different methods of its assessment are introduced. In addition, certain methods for the evaluation/operationalization of collected PA data are described. Finally, some epidemiological studies dealing with the associations between PA and overweight/obesity in children/adolescents as well as in adults are presented.

  15. Shared Activity Coordination

    NASA Technical Reports Server (NTRS)

    Clement, Bradley J.; Barrett, Anthony C.

    2003-01-01

    Interacting agents that interleave planning and execution must reach consensus on their commitments to each other. In domains where agents have varying degrees of interaction and different constraints on communication and computation, agents will require different coordination protocols in order to efficiently reach consensus in real time. We briefly describe a largely unexplored class of real-time, distributed planning problems (inspired by interacting spacecraft missions), new challenges they pose, and a general approach to solving the problems. These problems involve self-interested agents that have infrequent communication but collaborate on joint activities. We describe a Shared Activity Coordination (SHAC) framework that provides a decentralized algorithm for negotiating the scheduling of shared activities in a dynamic environment, a soft, real-time approach to reaching consensus during execution with limited communication, and a foundation for customizing protocols for negotiating planner interactions. We apply SHAC to a realistic simulation of interacting Mars missions and illustrate the simplicity of protocol development.

  16. Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma.

    PubMed

    Lee, Sang-Hyun; Jeung, In Cheul; Park, Tae Woo; Lee, Kyungmin; Lee, Dong Gwang; Cho, Young-Lai; Lee, Tae Sup; Na, Hee-Jun; Park, Young-Jun; Lee, Hee Gu; Jeong, Mun Sik; Bae, Kwang-Hee; Lee, Sang Chul; Lee, Hyo Jin; Kwon, Young-Guen; Hong, Hyo Jeong; Kim, Jang-Seong; Min, Jeong-Ki

    2015-03-30

    Endostatin is an endogenous angiogenesis inhibitor that exhibits potential anti-tumor efficacy in various preclinical animal models. However, its relatively short in vivo half-life and the long-term, frequent administration of high doses limit its widespread clinical use. In this study, we evaluated whether a fusion protein of murine endostatin (mEndo) to a humanized antibody against tumor-associated glycoprotein 72 (TAG-72), which is highly expressed in several human tumor tissues including colon cancer, can extend the serum half-life and improve the anti-tumor efficacy of endostatin by targeted delivery to the tumor mass. The fusion protein (3E8-mEndo) and mEndo showed improved anti-angiogenic activity in vitro and in vivo, predominantly by interfering with pro-angiogenic signaling triggered by vascular endothelial growth factor (VEGF). Moreover, in mice treated with 3E8-mEndo, we observed a markedly prolonged serum half-life and significantly inhibited tumor growth. The improved anti-tumor activity of 3E8-mEndo can be partially explained by increased local concentration in the tumor mass due to targeted delivery of 3E8-mEndo to implanted colon tumors. Collectively, our data clearly indicate that tumor-targeting antibody fusions to endostatin are a powerful strategy that improves the poor pharmacokinetic profile and anti-tumor efficacy of endostatin.

  17. Stochastic optical active rheology

    NASA Astrophysics Data System (ADS)

    Lee, Hyungsuk; Shin, Yongdae; Kim, Sun Taek; Reinherz, Ellis L.; Lang, Matthew J.

    2012-07-01

    We demonstrate a stochastic based method for performing active rheology using optical tweezers. By monitoring the displacement of an embedded particle in response to stochastic optical forces, a rapid estimate of the frequency dependent shear moduli of a sample is achieved in the range of 10-1-103 Hz. We utilize the method to probe linear viscoelastic properties of hydrogels at varied cross-linker concentrations. Combined with fluorescence imaging, our method demonstrates non-linear changes of bond strength between T cell receptors and an antigenic peptide due to force-induced cell activation.

  18. SCOR announces new activities

    NASA Astrophysics Data System (ADS)

    Urban, Edward R., Jr.

    Roger Revelle had many good ideas during his long and productive career. One of them came to fruition in 1957 in the form of the Scientific Committee on Oceanic Research (SCOR), which the International Council for Science created as its first interdisciplinary body, to promote international activities in oceanography. Revelle served as SCOR's first president from 1957 to 1960. SCOR offers opportunities for scientists from different countries to cooperate in planning and executing international programs in ocean sciences. Over its 44 years in existence, SCOR has sponsored 120 working groups and has actively participated in many of the major international oceanographic projects. Thirty-six nations presently participate as SCOR members.

  19. Active cleaning technique device

    NASA Technical Reports Server (NTRS)

    Shannon, R. L.; Gillette, R. B.

    1973-01-01

    The objective of this program was to develop a laboratory demonstration model of an active cleaning technique (ACT) device. The principle of this device is based primarily on the technique for removing contaminants from optical surfaces. This active cleaning technique involves exposing contaminated surfaces to a plasma containing atomic oxygen or combinations of other reactive gases. The ACT device laboratory demonstration model incorporates, in addition to plasma cleaning, the means to operate the device as an ion source for sputtering experiments. The overall ACT device includes a plasma generation tube, an ion accelerator, a gas supply system, a RF power supply and a high voltage dc power supply.

  20. Cosmogenic activation of materials

    SciTech Connect

    Amare, J.; Beltran, B.; Carmona, J.M.; Cebrian, S.; Garcia, E.; Irastorza, I.G.; Gomez, H.; Luzon, G.; Martinez, M.; Morales, J.; Ortiz de Solorzano, A.; Pobes, C.; Puimedon, J.; Rodriguez, A.; Ruz, J.; Sarsa, M. L.; Torres, L.; Villar, J.A.; Capelli, S.; Capozzi, F.

    2005-09-08

    The problem of cosmogenic activation produced at sea level in materials typically used in underground experiments looking for rare events is being studied. Several nuclear data libraries have been screened looking for relevant isotope production cross-sections and different codes which can be applied to activation studies have been reviewed. The excitation functions for some problems of interest like production of 60Co and 68Ge in germanium and production of 60Co in tellurium have been obtained taking into account both measurements and calculations and a preliminary estimate of the corresponding rates of production at sea level has been performed.