Science.gov

Sample records for activities generate hazardous

  1. Hazardous Waste Generators

    EPA Pesticide Factsheets

    Many industries generate hazardous waste. EPA regulates hazardous waste under the Resource Conservation and Recovery Act to ensure these wastes are managed in ways that are protective of human health and the environment.

  2. G-EVER Activities and the Next-generation Volcanic Hazard Assessment System

    NASA Astrophysics Data System (ADS)

    Takarada, S.

    2013-12-01

    The Asia-Pacific Region Global Earthquake and Volcanic Eruption Risk Management (G-EVER) is a consortium of Asia-Pacific geohazard research institutes that was established in 2012. G-EVER aims to formulate strategies to reduce the risks of disasters worldwide caused by the occurrence of earthquakes, tsunamis and volcanic eruptions. G-EVER is working on enhancing collaboration, sharing of resources, and making information on the risks of earthquakes and volcanic eruptions freely available and understandable. The 1st G-EVER International Symposium was held in Tsukuba, Japan in March 11, 2013. The 2nd Symposium is scheduled in Sendai, Tohoku Japan, in Oct. 19-20, 2013. Currently, 4 working groups were proposed in the G-EVER Consortium. The next-generation volcano hazard assessment WG is developing a useful system for volcanic eruption prediction, risk assessment, and evacuation at various eruption stages. The assessment system is based on volcanic eruption history datasets, volcanic eruption database, and numerical simulations. Volcanic eruption histories including precursor phenomena leading to major eruptions of active volcanoes are very important for future prediction of volcanic eruptions. A high quality volcanic eruption database, which contains compilations of eruption dates, volumes, and types, is important for the next-generation volcano hazard assessment system. Proposing international standards on how to estimate the volume of volcanic products is important to make a high quality volcanic eruption database. Spatial distribution database of volcanic products (e.g. tephra and pyroclastic flow distributions), encoded into a GIS based database is necessary for more precise area and volume estimation and risk assessments. The volcanic eruption database is developed based on past eruption results, which only represents a subset of possible future scenarios. Therefore, numerical simulations with controlled parameters are needed for more precise volcanic eruption

  3. Hazardous Waste Generator Regulations: A User-Friendly Reference Document

    EPA Pesticide Factsheets

    User-friendly reference to assist EPA and state staff, industrial facilities generating and managing hazardous wastes as well as the general public, in locating and understanding RCRA hazardous waste generator regulations.

  4. Audits of hazardous waste TSDFs let generators sleep easy. [Hazardous waste treatment, storage and disposal facility

    SciTech Connect

    Carr, F.H.

    1990-02-01

    Because of the increasingly strict enforcement of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and the Resource Conservation and Recovery Act (RCRA), generators of hazardous waste are compelled to investigate the hazardous waste treatment, storage and disposal facility (TSDF) they use. This investigation must include an environmental and a financial audit. Simple audits may be performed by the hazardous waste generator, while more thorough ones such as those performed for groups of generators are more likely to be conducted by environmental consultants familiar with treatment, storage, and disposal techniques and the regulatory framework that guides them.

  5. Regulatory compliance by small-quantity generators of hazardous waste

    SciTech Connect

    Deyle, R.E.

    1987-01-01

    While small quantity and very small quantity generators of hazardous waste (SQCs and VSQGs) are responsible for less than one percent of the total hazardous waste produced, mismanagement of even small quantities of many types of hazardous waste can cause significant local impacts. Most SQGs and VSQGs are also small businesses. They are presumed to face significant time, expertise, and other resource constraints in complying with legally and technically complex regulations such as those that govern hazardous waste management. A sample of 400 SQGs and VSQGs in New Jersey was surveyed to assess policy options for two policy issues identified by the New Jersey Hazardous Waste Facilities Siting Commission: (1) enhancing regulatory compliance by SQGs, and (2) promoting voluntary adherence with hazardous waste regulations by VSQGs in the state. The analysis empirically tests hypotheses based on the rational utility maximization and bounded rationality models of individual and organizational decision making and compliance behavior.

  6. 1993 annual report of hazardous waste activities for the Oak Ridge K-25 site

    SciTech Connect

    Not Available

    1994-02-01

    This report is a detailed listing of all of the Hazardous Waste activities occurring at Martin Marietta`s K-25 site. Contained herein are hazardous waste notification forms, waste stream reports, generator fee forms and various TSDR reports.

  7. 75 FR 82005 - Agency Information Collection Activities; Proposed Collection; Comment Request; Hazardous Waste...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ...] Agency Information Collection Activities; Proposed Collection; Comment Request; Hazardous Waste Generator.... Title: Hazardous Waste Generator Standards (Renewal). ICR numbers: EPA ICR No. 0820.11, OMB Control No... RCRA requires EPA to develop standards for small quantity generators. Section 3002 of RCRA...

  8. Impact-generated Tsunamis: An Over-rated Hazard

    NASA Technical Reports Server (NTRS)

    Melosh, H. J.

    2003-01-01

    A number of authors have suggested that oceanic waves (tsunami) created by the impact of relatively small asteroids into the Earth's oceans might cause widespread devastation to coastal cities. If correct, this suggests that asteroids > 100 m in diameter may pose a serious hazard to humanity and could require a substantial expansion of the current efforts to identify earth-crossing asteroids > 1 km in diameter. The debate on this hazard was recently altered by the release of a document previously inaccessible to the scientific community. In 1968 the US Office of Naval Research commissioned a summary of several decades of research into the hazard proposed by waves generated by nuclear explosions in the ocean. Authored by tsunami expert William Van Dorn, this 173-page report entitled Handbook of Explosion-Generated Water Waves affords new insight into the process of impact wave formation, propagation, and run up onto the shoreline.

  9. Methodologies for estimating one-time hazardous waste generation for capacity generation for capacity assurance planning

    SciTech Connect

    Tonn, B.; Hwang, Ho-Ling; Elliot, S.; Peretz, J.; Bohm, R.; Hendrucko, B.

    1994-04-01

    This report contains descriptions of methodologies to be used to estimate the one-time generation of hazardous waste associated with five different types of remediation programs: Superfund sites, RCRA Corrective Actions, Federal Facilities, Underground Storage Tanks, and State and Private Programs. Estimates of the amount of hazardous wastes generated from these sources to be shipped off-site to commercial hazardous waste treatment and disposal facilities will be made on a state by state basis for the years 1993, 1999, and 2013. In most cases, estimates will be made for the intervening years, also.

  10. Guidelines for generators of hazardous chemical waste at LBL and guidelines for generators of radioactive and mixed waste at LBL. Revision 2

    SciTech Connect

    Not Available

    1993-10-01

    The purpose of this document is to provide the acceptance criteria for the transfer of hazardous chemical waste to LBL`s Hazardous Waste Handling Facility (HWHF). Hazardous chemical waste is a necessary byproduct of LBL`s research and technical support activities. This waste must be handled properly if LBL is to operate safely and provide adequate protection to staff and the environment. These guidelines describe how you, as a generator of hazardous chemical waste, can meet LBL`s acceptance criteria for hazardous chemical waste.

  11. A weather generator for hydro-meteorological hazard applications

    NASA Astrophysics Data System (ADS)

    Breinl, Korbinian; Turkington, Thea; Stowasser, Markus

    2014-05-01

    A new multi-site weather generator is proposed here. Multi-site weather generators are designed to simulate the space-time variation of precipitation and temperature at more than one location. A semi-parametric multi-site precipitation generator was recently proposed by Breinl et. al. (Breinl, K., Turkington, T. and Stowasser, M. 2013. Stochastic generation of multi-site daily precipitation for applications in risk management. Journal of Hydrology, 498: 23-35). A univariate Markov process was used to model precipitation occurrence at five sites in two study areas, with precipitation amounts simulated by resampling observations and then sampling and reshuffling from a parametric precipitation distribution (Breinl et. al., 2013). In this work, the precipitation model by Breinl et. al. (2013) is implemented in a weather generator for daily precipitation and temperature. The daily precipitation generator is extended for a considerably larger network of 19 sites in the Salzach catchment (Austria) and further improved to reduce the duplication of historical observations in the simulation output. Temperature is modelled using an autoregressive-moving average model (ARMA), simulating mean daily temperature at three of the 19 sites. Extreme values have also been considered, as they are often important for hydro-meteorological hazard applications. In the proposed weather generator, power transformations reduce the bias of generated extreme temperatures. The parametric models for precipitation are comprised of Weibull distributions for low precipitation amounts and Generalised Pareto distributions to more accurately capture moderate and extreme precipitation. With its abilities to reproduce the spatial variability of precipitation as well as unobserved extremes, the proposed weather generator is particularly recommended for flood hazard and risk assessment.

  12. Solar activities and Climate change hazards

    NASA Astrophysics Data System (ADS)

    Hady, A. A., II

    2014-12-01

    Throughout the geological history of Earth, climate change is one of the recurrent natural hazards. In recent history, the impact of man brought about additional climatic change. Solar activities have had notable effect on palaeoclimatic changes. Contemporary, both solar activities and building-up of green-house gases effect added to the climatic changes. This paper discusses if the global worming caused by the green-house gases effect will be equal or less than the global cooling resulting from the solar activities. In this respect, we refer to the Modern Dalton Minimum (MDM) which stated that starting from year 2005 for the next 40 years; the earth's surface temperature will become cooler than nowadays. However the degree of cooling, previously mentioned in old Dalton Minimum (c. 210 y ago), will be minimized by building-up of green-house gases effect during MDM period. Regarding to the periodicities of solar activities, it is clear that now we have a new solar cycle of around 210 years. Keywords: Solar activities; solar cycles; palaeoclimatic changes; Global cooling; Modern Dalton Minimum.

  13. Identifying hazard parameter to develop quantitative and dynamic hazard map of an active volcano in Indonesia

    NASA Astrophysics Data System (ADS)

    Suminar, Wulan; Saepuloh, Asep; Meilano, Irwan

    2016-05-01

    Analysis of hazard assessment to active volcanoes is crucial for risk management. The hazard map of volcano provides information to decision makers and communities before, during, and after volcanic crisis. The rapid and accurate hazard assessment, especially to an active volcano is necessary to be developed for better mitigation on the time of volcanic crises in Indonesia. In this paper, we identified the hazard parameters to develop quantitative and dynamic hazard map of an active volcano. The Guntur volcano in Garut Region, West Java, Indonesia was selected as study area due population are resided adjacent to active volcanoes. The development of infrastructures, especially related to tourism at the eastern flank from the Summit, are growing rapidly. The remote sensing and field investigation approaches were used to obtain hazard parameters spatially. We developed a quantitative and dynamic algorithm to map spatially hazard potential of volcano based on index overlay technique. There were identified five volcano hazard parameters based on Landsat 8 and ASTER imageries: volcanic products including pyroclastic fallout, pyroclastic flows, lava and lahar, slope topography, surface brightness temperature, and vegetation density. Following this proposed technique, the hazard parameters were extracted, indexed, and calculated to produce spatial hazard values at and around Guntur Volcano. Based on this method, the hazard potential of low vegetation density is higher than high vegetation density. Furthermore, the slope topography, surface brightness temperature, and fragmental volcanic product such as pyroclastics influenced to the spatial hazard value significantly. Further study to this proposed approach will be aimed for effective and efficient analyses of volcano risk assessment.

  14. A pilot outreach program for small quantity generators of hazardous waste.

    PubMed

    Brown, M S; Kelley, B G; Gutensohn, J

    1988-10-01

    The Massachusetts Department of Environmental Management initiated a pilot project to improve compliance with hazardous waste regulations and management of hazardous wastes with auto body shops around the state. The program consisted of mass mailings, a series of workshops throughout the state, a coordinated inspection program by the state regulatory agency, and technology transfer. At the start of the program in January 1986, approximately 650 of the estimated 2,350 auto body shops in the state had notified EPA of their waste generating activities; by January 1987, approximately 1,200 shops had done so. Suggestions for improving program efforts include tailoring the outreach effort to the industry, government-sponsored research and development directed at the needs of small firms, mandatory participation in hazardous waste transportation programs, and better coordination by EPA of its information collection and distribution program.

  15. Guidelines for generators of hazardous chemical waste at LBL and Guidelines for generators of radioactive and mixed waste at LBL

    SciTech Connect

    Not Available

    1991-07-01

    The purpose of this document is to provide the acceptance criteria for the transfer of hazardous chemical, radioactive, and mixed waste to Lawrence Berkeley Laboratory's (LBL) Hazardous Waste Handling Facility (HWHF). These guidelines describe how a generator of wastes can meet LBL's acceptance criteria for hazardous chemical, radioactive, and mixed waste. 9 figs.

  16. Active polarimeter optical system laser hazard analysis.

    SciTech Connect

    Augustoni, Arnold L.

    2005-07-01

    A laser hazard analysis was performed for the SNL Active Polarimeter Optical System based on the ANSI Standard Z136.1-2000, American National Standard for Safe Use of Lasers and the ANSI Standard Z136.6-2000, American National Standard for Safe Use of Lasers Outdoors. The Active Polarimeter Optical System (APOS) uses a pulsed, near-infrared, chromium doped lithium strontium aluminum fluoride (Cr:LiSAF) crystal laser in conjunction with a holographic diffuser and lens to illuminate a scene of interest. The APOS is intended for outdoor operations. The system is mounted on a height adjustable platform (6 feet to 40 feet) and sits atop a tripod that points the beam downward. The beam can be pointed from nadir to as much as 60 degrees off of nadir producing an illuminating spot geometry that can vary from circular (at nadir) to elliptical in shape (off of nadir). The JP Innovations crystal Cr:LiSAF laser parameters are presented in section II. The illuminating laser spot size is variable and can be adjusted by adjusting the separation distance between the lens and the holographic diffuser. The system is adjusted while platform is at the lowest level. The laser spot is adjusted for a particular spot size at a particular distance (elevation) from the laser by adjusting the separation distance (d{sub diffuser}) to predetermined values. The downward pointing angle is also adjusted before the platform is raised to the selected operation elevation.

  17. Generating Random Earthquake Events for Probabilistic Tsunami Hazard Assessment

    NASA Astrophysics Data System (ADS)

    LeVeque, Randall J.; Waagan, Knut; González, Frank I.; Rim, Donsub; Lin, Guang

    2016-12-01

    To perform probabilistic tsunami hazard assessment for subduction zone earthquakes, it is necessary to start with a catalog of possible future events along with the annual probability of occurrence, or a probability distribution of such events that can be easily sampled. For near-field events, the distribution of slip on the fault can have a significant effect on the resulting tsunami. We present an approach to defining a probability distribution based on subdividing the fault geometry into many subfaults and prescribing a desired covariance matrix relating slip on one subfault to slip on any other subfault. The eigenvalues and eigenvectors of this matrix are then used to define a Karhunen-Loève expansion for random slip patterns. This is similar to a spectral representation of random slip based on Fourier series but conforms to a general fault geometry. We show that only a few terms in this series are needed to represent the features of the slip distribution that are most important in tsunami generation, first with a simple one-dimensional example where slip varies only in the down-dip direction and then on a portion of the Cascadia Subduction Zone.

  18. Landslide-Generated Tsunami Model for Quick Hazard Assessment

    NASA Astrophysics Data System (ADS)

    Franz, M.; Rudaz, B.; Locat, J.; Jaboyedoff, M.; Podladchikov, Y.

    2015-12-01

    Alpine regions are likely to be areas at risk regarding to landslide-induced tsunamis, because of the proximity between lakes and potential instabilities and due to the concentration of the population in valleys and on the lakes shores. In particular, dam lakes are often surrounded by steep slopes and frequently affect the stability of the banks. In order to assess comprehensively this phenomenon together with the induced risks, we have developed a 2.5D numerical model which aims to simulate the propagation of the landslide, the generation and the propagation of the wave and eventually the spread on the shores or the associated downstream flow. To perform this task, the process is done in three steps. Firstly, the geometry of the sliding mass is constructed using the Sloping Local Base Level (SLBL) concept. Secondly, the propagation of this volume is performed using a model based on viscous flow equations. Finally, the wave generation and its propagation are simulated using the shallow water equations stabilized by the Lax-Friedrichs scheme. The transition between wet and dry bed is performed by the combination of the two latter sets of equations. The proper behavior of our model is demonstrated by; (1) numerical tests from Toro (2001), and (2) by comparison with a real event where the horizontal run-up distance is known (Nicolet landslide, Quebec, Canada). The model is of particular interest due to its ability to perform quickly the 2.5D geometric model of the landslide, the tsunami simulation and, consequently, the hazard assessment.

  19. 40 CFR 261.5 - Special requirements for hazardous waste generated by conditionally exempt small quantity...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... waste generated by conditionally exempt small quantity generators. 261.5 Section 261.5 Protection of... small quantity generators. (a) A generator is a conditionally exempt small quantity generator in a... small quantity generator's hazardous wastes are not subject to regulation under parts 262 through...

  20. 40 CFR 261.5 - Special requirements for hazardous waste generated by conditionally exempt small quantity...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... waste generated by conditionally exempt small quantity generators. 261.5 Section 261.5 Protection of... small quantity generators. (a) A generator is a conditionally exempt small quantity generator in a... small quantity generator's hazardous wastes are not subject to regulation under parts 262 through...

  1. 40 CFR 261.5 - Special requirements for hazardous waste generated by conditionally exempt small quantity...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... waste generated by conditionally exempt small quantity generators. 261.5 Section 261.5 Protection of... small quantity generators. (a) A generator is a conditionally exempt small quantity generator in a... small quantity generator's hazardous wastes are not subject to regulation under parts 262 through...

  2. Next-Generation GPS Station for Hazards Mitigation (Invited)

    NASA Astrophysics Data System (ADS)

    Bock, Y.

    2013-12-01

    Our objective is to better forecast, assess, and mitigate natural hazards, including earthquakes, tsunamis, and extreme storms and flooding through development and implementation of a modular technology for the next-generation in-situ geodetic station to support the flow of information from multiple stations to scientists, mission planners, decision makers, and first responders. The same technology developed under NASA funding can be applied to enhance monitoring of large engineering structures such as bridges, hospitals and other critical infrastructure. Meaningful warnings save lives when issued within 1-2 minutes for destructive earthquakes, several tens of minutes for tsunamis, and up to several hours for extreme storms and flooding, and can be provided by on-site fusion of multiple data types and generation of higher-order data products: GPS/GNSS and accelerometer measurements to estimate point displacements, and GPS/GNSS and meteorological measurements to estimate moisture variability in the free atmosphere. By operating semi-autonomously, each station can then provide low-latency, high-fidelity and compact data products within the constraints of narrow communications bandwidth that often accompanies natural disasters. We have developed a power-efficient, low-cost, plug-in Geodetic Module for fusion of data from in situ sensors including GPS, a strong-motion accelerometer module, and a meteorological sensor package, for deployment at existing continuous GPS stations in southern California; fifteen stations have already been upgraded. The low-cost modular design is scalable to the many existing continuous GPS stations worldwide. New on-the-fly data products are estimated with 1 mm precision and accuracy, including three-dimensional seismogeodetic displacements for earthquake, tsunami and structural monitoring and precipitable water for forecasting extreme weather events such as summer monsoons and atmospheric rivers experienced in California. Unlike more

  3. Characterization of hazardous constituents in HLW supernate and implications for solid LLW generation

    SciTech Connect

    Georgeton, G.K.

    1994-10-10

    High Level Waste (HLW) generated during Separations processing in the F- and H-Canyons is transferred to the Tank Farms for stage in 51 underground, million gallon storage tanks. The waste is an aqueous solution containing dissolved sodium salts and insoluble metal oxides/hydroxides. The waste solution is evaporated to reduce the volume, and the resulting saltcake and residual supernate are stored. Over the 40 year history of the Tank Farm, routine supernate sampling has been conducted in support of the primary goal of safe storage of HLW. As a result of routine and non-routine activities that are part of managing these highly radioactive wastes, secondary solid waste is generated. Radioactive contamination of over 90% of the solid waste generated is due to contact with BLW supernate or saltcake. In order to comply with the Waste Acceptance Criteria (WAC) for of solid waste in the E-Area Vaults (EAV), the quantity of certain radioisotopes must be manifested for each waste container and a declaration made of whether or not the waste is hazardous. However, solid waste is not amenable to routine analysis, this forces a reliance on analytical data from supernate samples to characterize the contamination. To provide the manifest information, process knowledge in combination with the limited amount of analytical data will be used. This report documents the characterization of hazardous components in the HLW supernate associated with the waste storage, evaporation and sludge processing facilities. The hazardous constituents of HLW are identified and the fate of the constituents is tracked based on knowledge of each phase of the process. The limited amount of sample data that includes analyses for hazardous species is then used to establish average and maximum characterization values. Finally, a screening based on an average supernate is compared to the criteria for the individual streams to evaluate the amount of conservatism introduced for the individual streams.

  4. Plasma Hazards and Acceptance for International Space Station Extravehicular Activities

    NASA Astrophysics Data System (ADS)

    Patton, Thomas

    2010-09-01

    Extravehicular activity(EVA) is accepted by NASA and other space faring agencies as a necessary risk in order to build and maintain a safe and efficient laboratory in space. EVAs are used for standard construction and as contingency operations to repair critical equipment for vehicle sustainability and safety of the entire crew in the habitable volume. There are many hazards that are assessed for even the most mundane EVA for astronauts, and the vast majority of these are adequately controlled per the rules of the International Space Station Program. The need for EVA repair and construction has driven acceptance of a possible catastrophic hazard to the EVA crewmember which cannot currently be controlled adequately. That hazard is electrical shock from the very environment in which they work. This paper describes the environment, causes and contributors to the shock of EVA crewmembers attributed to the ionospheric plasma environment in low Earth orbit. It will detail the hazard history, and acceptance process for the risk associated with these hazards that give assurance to a safe EVA. In addition to the hazard acceptance process this paper will explore other factors that go into the decision to accept a risk including criticality of task, hardware design and capability, and the probability of hazard occurrence. Also included will be the required interaction between organizations at NASA(EVA Office, Environments, Engineering, Mission Operations, Safety) in order to build and eventually gain adequate acceptance rationale for a hazard of this kind. During the course of the discussion, all current methods of mitigating the hazard will be identified. This paper will capture the history of the plasma hazard analysis and processes used by the International Space Station Program to formally assess and qualify the risk. The paper will discuss steps that have been taken to identify and perform required analysis of the floating potential shock hazard from the ISS environment

  5. 40 CFR 271.10 - Requirements for generators of hazardous wastes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Requirements for generators of... for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State program must cover all generators covered by 40 CFR part 262. States must require new generators...

  6. 40 CFR 271.10 - Requirements for generators of hazardous wastes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Requirements for generators of... for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State program must cover all generators covered by 40 CFR part 262. States must require new generators...

  7. 40 CFR 271.10 - Requirements for generators of hazardous wastes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Requirements for generators of... for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State program must cover all generators covered by 40 CFR part 262. States must require new generators...

  8. 40 CFR 271.10 - Requirements for generators of hazardous wastes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Requirements for generators of... for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State program must cover all generators covered by 40 CFR part 262. States must require new generators...

  9. 40 CFR 271.10 - Requirements for generators of hazardous wastes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Requirements for generators of... for Final Authorization § 271.10 Requirements for generators of hazardous wastes. (a) The State program must cover all generators covered by 40 CFR part 262. States must require new generators...

  10. 77 FR 31005 - Agency Information Collection Activities; Proposed Collection; Comment Request; 2013 Hazardous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... Information Collection Activities; Proposed Collection; Comment Request; 2013 Hazardous Waste Report, Notification of Regulated Waste Activity, and Part A Hazardous Waste Permit Application and Modification AGENCY... proposed changes to the Hazardous Waste Report form and instructions designed to clarify...

  11. Active Nitrogen Generation.

    DTIC Science & Technology

    1987-06-01

    Project Officer FOR THE COMMANDER GERALD A. HASEN HARROACKERMANN Major, USAF Lt Col, USAF Chief, Advanced Chemical Laser Br Chief, Laser Science...SUPPLEMENTARY NOTATION 17. COSATI CODES I. SUJIECT TERMS lCntilnale o nnreqre if neetmay and identiy by Nocb awnubr) FlO GROUP Sue. n. Chemical lasers ...evalua- tion of the H + NF2 flame as a potential N2(A) generator for a high energy chemical laser . llAccesii For NTIS CRA&I l V IC TAR_

  12. Hazardous Wastes and the Consumer Connection. A Guide for Educators and Citizens Concerned with the Role of Consumers in the Generation of Hazardous Wastes.

    ERIC Educational Resources Information Center

    Assaff, Edith

    Many consumers do not see a strong connection between our lifestyles and buying decisions, and the amount of hazardous wastes generated in the United States. This guide was developed to be used by educators and citizens concerned with the role of consumers in the generation of hazardous wastes. It examines several products in terms of their…

  13. Active droplet generation in microfluidics.

    PubMed

    Chong, Zhuang Zhi; Tan, Say Hwa; Gañán-Calvo, Alfonso M; Tor, Shu Beng; Loh, Ngiap Hiang; Nguyen, Nam-Trung

    2016-01-07

    The reliable generation of micron-sized droplets is an important process for various applications in droplet-based microfluidics. The generated droplets work as a self-contained reaction platform in droplet-based lab-on-a-chip systems. With the maturity of this platform technology, sophisticated and delicate control of the droplet generation process is needed to address increasingly complex applications. This review presents the state of the art of active droplet generation concepts, which are categorized according to the nature of the induced energy. At the liquid/liquid interface, an energy imbalance leads to instability and droplet breakup.

  14. Integrated management of hazardous waste generated from community sources in Thailand

    SciTech Connect

    Yodnane, P.; Spaeder, D.J.

    1999-07-01

    A system for the collection, transport, disposal and recycling of hazardous waste was developed as part of an overall master plan for the management of hazardous waste generated from community sources in Thailand. Results of a waste generation survey conducted as part of the study indicated that over 300 million kilograms per year of hazardous waste is generated from non-industrial, community sources such as automotive repair shops, gas stations, hospitals, farms, and households in Thailand. Hazardous waste from community sources consists primarily of used oils, lead-acid and dry cell batteries, cleaning chemicals, pesticides, medical wastes, solvents and fuels. Most of this waste was found to be mismanaged by codisposing with municipal waste in burning, unlined dumps, dumping directly to land or water courses, dumping into sewers, or recycling improperly, all of which pose serious threats to human health and the environment. The survey data on waste generation quantities and data from a reconnaissance survey of the conditions and operations of 86 existing waste disposal facilities was incorporated into a nationwide Geographic Information System (GIS) database. Based on this data, problems associated with hazardous waste were identified and needs for waste management systems were tabulated. A system was developed for ranking geographic regions according to hazardous waste management problems and needs, in order to prioritize implementation of waste management programs. The data were also used in developing solutions for hazardous waste management, which addressed methods for storing, collecting, transporting, disposing, and recycling the waste. It was recommended that centralized waste management facilities be utilized which included hazardous waste and medical waste incinerators, waste stabilization units, and secure landfills.

  15. Seismic hazard assessment of Syria using seismicity, DEM, slope, active tectonic and GIS

    NASA Astrophysics Data System (ADS)

    Ahmad, Raed; Adris, Ahmad; Singh, Ramesh

    2016-07-01

    In the present work, we discuss the use of an integrated remote sensing and Geographical Information System (GIS) techniques for evaluation of seismic hazard areas in Syria. The present study is the first time effort to create seismic hazard map with the help of GIS. In the proposed approach, we have used Aster satellite data, digital elevation data (30 m resolution), earthquake data, and active tectonic maps. Many important factors for evaluation of seismic hazard were identified and corresponding thematic data layers (past earthquake epicenters, active faults, digital elevation model, and slope) were generated. A numerical rating scheme has been developed for spatial data analysis using GIS to identify ranking of parameters to be included in the evaluation of seismic hazard. The resulting earthquake potential map delineates the area into different relative susceptibility classes: high, moderate, low and very low. The potential earthquake map was validated by correlating the obtained different classes with the local probability that produced using conventional analysis of observed earthquakes. Using earthquake data of Syria and the peak ground acceleration (PGA) data is introduced to the model to develop final seismic hazard map based on Gutenberg-Richter (a and b values) parameters and using the concepts of local probability and recurrence time. The application of the proposed technique in Syrian region indicates that this method provides good estimate of seismic hazard map compared to those developed from traditional techniques (Deterministic (DSHA) and probabilistic seismic hazard (PSHA). For the first time we have used numerous parameters using remote sensing and GIS in preparation of seismic hazard map which is found to be very realistic.

  16. Wildfire Research in an Environmental Hazards Course: An Active Learning Approach

    ERIC Educational Resources Information Center

    Wall, Tamara U.; Halvorson, Sarah J.

    2011-01-01

    Creating opportunities for students to actively apply hazards theory to real-life situations is often a challenge in hazards geography courses. This article presents a project, the Jocko Lakes Fire Project, that implemented learning strategies to encourage students to be active in wildfire hazards research. Wildfire hazards stand out as an…

  17. Estimating maquiladora hazardous waste generation on the U.S./Mexico border

    NASA Astrophysics Data System (ADS)

    Bowen, Mace M.; Kontuly, Thomas; Hepner, George F.

    1995-03-01

    Maquiladoras, manufacturing plants that primarily assemble foreign components for reexport, are located in concentrations along the northern frontier of the US/Mexico border. These plants process a wide variety of materials using modern industrial technologies within the context of developing world institutions and infrastructure. Hazardous waste generation by maquiladoras represents a critical environmental management issue because of the spatial concentration of these plants in border municipalities where the infrastructure for waste management is nonexistent or poor. These border municipalities contain rapidly increasing populations, which further stress their waste handling infrastructure capacities while exposing their populations to greater contaminant risks. Limited empirical knowledge exists concerning hazardous waste types and generation rates from maquiladorsas. There is no standard reporting method for waste generation or methodology for estimating generation rates at this time. This paper presents a method that can be used for the rapid assessment of hazardous waste generation. A first approximation of hazardous waste generation is produced for maquiladoras in the three municipalities of Nogales, Sonora, Mexicali, Baja California, and Cd. Juarez, Chihuahua, using the INVENT model developed by the World Bank. In addition, our intent is to evaluate the potential of the INVENT model for adaptation to the US/Mexico border industrial situation. The press of border industrial development, especially with the recent adoption of the NAFTA, make such assessments necessary as a basis for the environmental policy formulation and management needed in the immediate future.

  18. Guidelines for generators of hazardous chemical waste at LBL and guidelines for generators of radioactive and mixed waste at LBL

    SciTech Connect

    Not Available

    1991-09-01

    In part one of this document the Governing Documents and Definitions sections provide general guidelines and regulations applying to the handling of hazardous chemical wastes. The remaining sections provide details on how you can prepare your waste properly for transport and disposal. They are correlated with the steps you must take to properly prepare your waste for pickup. The purpose of the second part of this document is to provide the acceptance criteria for the transfer of radioactive and mixed waste to LBL's Hazardous Waste Handling Facility (HWHF). These guidelines describe how you, as a generator of radioactive or mixed waste, can meet LBL's acceptance criteria for radioactive and mixed waste.

  19. Crew activities, science, and hazards of manned missions to Mars

    NASA Technical Reports Server (NTRS)

    Clark, Benton C.

    1988-01-01

    The crew scientific and nonscientific activities that will occur at each stage of a mission to Mars are examined. Crew activities during the interplanetary flight phase will include simulations, maintenance and monitoring, communications, upgrading procedures and operations, solar activity monitoring, cross-training and sharpening of skills, physical conditioning, and free-time activities. Scientific activities will address human physiology, human psychology, sociology, astronomy, space environment effects, manufacturing, and space agriculture. Crew activities on the Martian surface will include exploration, construction, manufacturing, food production, maintenance and training, and free time. Studies of Martian geology and atmosphere, of the life forms that may exist there, and of the Martian moons will occur on the planet's surface. Crew activities and scientific studies that will occur in Mars orbit, and the hazards relevant to each stage of the mission, are also addressed.

  20. Small Generator, Large Problem: Identifying and Disposing of Hazardous Waste at Two-Year Colleges.

    ERIC Educational Resources Information Center

    Valicenti, John A.

    1993-01-01

    Despite limited generation of hazardous materials, two-year colleges are required to comply with federal criteria for their identification and removal. After a random facilities inspection, the College of DuPage (Illinois) established priorities for waste removal, information dissemination, staff training, inventory, storage, and organizational…

  1. Environmental justice implications of industrial hazardous waste generation in India: a national scale analysis

    NASA Astrophysics Data System (ADS)

    Basu, Pratyusha; Chakraborty, Jayajit

    2016-12-01

    While rising air and water pollution have become issues of widespread public concern in India, the relationship between spatial distribution of environmental pollution and social disadvantage has received less attention. This lack of attention becomes particularly relevant in the context of industrial pollution, as India continues to pursue industrial development policies without sufficient regard to its adverse social impacts. This letter examines industrial pollution in India from an environmental justice (EJ) perspective by presenting a national scale study of social inequities in the distribution of industrial hazardous waste generation. Our analysis connects district-level data from the 2009 National Inventory of Hazardous Waste Generating Industries with variables representing urbanization, social disadvantage, and socioeconomic status from the 2011 Census of India. Our results indicate that more urbanized and densely populated districts with a higher proportion of socially and economically disadvantaged residents are significantly more likely to generate hazardous waste. The quantity of hazardous waste generated is significantly higher in more urbanized but sparsely populated districts with a higher proportion of economically disadvantaged households, after accounting for other relevant explanatory factors such as literacy and social disadvantage. These findings underscore the growing need to incorporate EJ considerations in future industrial development and waste management in India.

  2. Health-hazard evaluation report HETA 89-270-2080, Harrisburg Steam Generation Facility, Harrisburg, Pennsylvania

    SciTech Connect

    Seitz, T.A.

    1990-11-01

    In response to a request from the City of Harrisburg, Pennsylvania, a health hazard evaluation was conducted at the Harrisburg Steam Generation Facility (HSGF)(SIC-4953) concerning possible exposure to fly ash, combustion products and asbestos (1332214). The facility was a waste to energy site where municipal refuse was incinerated at approximately 1400 degrees-F. The steam generated was either sold directly or converted to electricity via an on site turbine. Employees used hard hats, safety shoes and glasses, work clothes and single use disposable dust and mist respirators. There was a potential for exposure to fly ash for employees working in the boiler and basement areas. Total particulate exposures ranged from 5 to llmg/m3 for laborers. The concentration of lead (7439921) exceeded the standards set by OSHA permissible exposure level of 0.05mg/kg in three of the personal breathing zone air samples. Amosite (12172735) and chrysotile (12001295) asbestos were identified in bulk samples of insulation and asbestos taken from a settled dust sample in the boiler area. Surface wipe samples indicated the possibility of hand to mouth contact with fly ash, particularly in the break and locker rooms. The author concludes that there is a need for reducing worker exposure to fly ash particulate. The author recommends engineering and work practice controls to reduce particulate exposures, increased cleaning and maintenance activities; and further evaluation of asbestos contamination at the facility.

  3. Simulations of Active Vortex Generators

    NASA Technical Reports Server (NTRS)

    Mansour, N. N.; Koumoutsakos, P.; Merriam, Marshal (Technical Monitor)

    1996-01-01

    We are interested in the study, via numerical simulations, of active vortex generators. Vortex generators may be used to modify the inner part of the boundary layer or to control separation thus enhancing the performance and maneuverability of aerodynamic configurations. We consider generators that consist of a surface cavity elongated in the streamwise direction and partially covered with a moving lid that at rest lies flush with the boundary. Streamwise voracity is generated and ejected due to the oscillatory motion of the lid. The present simulations c Implement relevant experimental investigations of active vortex generators that have been conducted at NASA Ames Research Center and Stanford University. Jacobson and Reynolds used a piezoelectric device in water, allowing for small amplitude high frequency oscillations. They placed the lid asymmetrically on the cavity and observed a strong outward velocity at the small gap of the cavity. Saddoughi used a larger mechanically driven device in air to investigate this flow and observed a jet emerging from the wide gap of the configuration, contrary to the findings of Jacobson and Reynolds. More recently, Lachowiez and Wlezien are investigating the flow generated by an electro-mechanically driven lid to be used for assertion control in aerodynamic applications. We are simulating the flows generated by these devices and we are conducting a parametric study that would help us elucidate the physical mechanisms present in the flow. Conventional computational schemes encounter difficulties when simulating flows around complex configurations undergoing arbitrary motions. Here we present a formulation that achieves this task on a purely Lagrangian frame by extending the formulation presented by Koumoutsakos, Leonard and Pepin. The viscous effects are taken into account by modifying the strength of the particles, whereas fast multipole schemes employing hundreds of thousands ol'particle's allow for high resolution simulations

  4. Probabilistic Hazard of Tsunamis Generated by Submarine Landslides in the Cook Strait Canyon (New Zealand)

    NASA Astrophysics Data System (ADS)

    Lane, Emily M.; Mountjoy, Joshu J.; Power, William L.; Mueller, Christof

    2016-12-01

    Cook Strait Canyon is a submarine canyon that lies within ten kilometres of Wellington, the capital city of New Zealand. The canyon walls are covered with scars from previous landslides which could have caused local tsunamis. Palaeotsunami evidence also points to past tsunamis in the Wellington region. Furthermore, the canyon's location in Cook Strait means that there is inhabited land in the path of both forward- and backward-propagating waves. Tsunamis induced by these submarine landslides pose hazard to coastal communities and infrastructure but major events are very uncommon and the historical record is not extensive enough to quantify this hazard. The combination of infrequent but potentially very consequential events makes realistic assessment of the hazard challenging. However, information on both magnitude and frequency is very important for land use planning and civil defence purposes. We use a multidisciplinary approach bringing together geological information with modelling to construct a Probabilistic Tsunami Hazard Assessment of submarine landslide-generated tsunami. Although there are many simplifying assumptions used in this assessment, it suggests that the Cook Strait open coast is exposed to considerable hazard due to submarine landslide-generated tsunamis. We emphasise the uncertainties involved and present opportunities for future research.

  5. Simulations of Active Vortex Generators

    NASA Technical Reports Server (NTRS)

    Mansour, N. N.; Koumoutsakos, P.; Merriam, Marshal (Technical Monitor)

    1996-01-01

    We are interested in the study, via numerical simulations, of active vortex generators. Vortex generators may be used to modify the inner part of the boundary layer or to control separation thus enhancing the performance and maneuverability of aerodynamic configurations. we consider generators that consist of a surface cavity elongated in the streamwise direction and partially covered with a moving lid that at rest lies flush with the boundary. Streamwise vorticity is generated and ejected due to the oscillatory motion of the lid. The present simulations complement relevant experimental investigations of active vortex generators that have been conducted at NASA Ames Research Center and Stanford University used a piezoelectric device in water, allowing for small amplitude high frequency oscillations. They placed the lid asymmetrically on the cavity and observed a strong outward velocity at the small gap of the cavity. Saddoughi used a larger mechanically driven device in air to investigate this flow and observed a jet emerging from the wide gap of the configuration, contrary to the findings of Jacobson and Reynolds We are simulating the flows generated by these devices and we are conducting a parametric study that would help us elucidate the physical mechanisms present in the flow. Conventional computational schemes encounter difficulties when simulating flows around complex configurations undergoing arbitrary motions. Here we present a formulation that achieves this task on a purely Lagrangian frame by extending the formulation presented by Koumoutsakos, Leonard and Pepin (1994). The viscous effects are taken into account by modifying the strength Of the particles, whereas fast multipole schemes employing hundreds of thousands of particles allow for high resolution simulations. We shall present simulation results of an oscillating plate at various Reynolds numbers and Strouhal frequencies.

  6. Recent Progress in Understanding Natural-Hazards-Generated TEC Perturbations: Measurements and Modeling Results

    NASA Astrophysics Data System (ADS)

    Komjathy, A.; Yang, Y. M.; Meng, X.; Verkhoglyadova, O. P.; Mannucci, A. J.; Langley, R. B.

    2015-12-01

    Natural hazards, including earthquakes, volcanic eruptions, and tsunamis, have been significant threats to humans throughout recorded history. The Global Positioning System satellites have become primary sensors to measure signatures associated with such natural hazards. These signatures typically include GPS-derived seismic deformation measurements, co-seismic vertical displacements, and real-time GPS-derived ocean buoy positioning estimates. Another way to use GPS observables is to compute the ionospheric total electron content (TEC) to measure and monitor post-seismic ionospheric disturbances caused by earthquakes, volcanic eruptions, and tsunamis. Research at the University of New Brunswick (UNB) laid the foundations to model the three-dimensional ionosphere at NASA's Jet Propulsion Laboratory by ingesting ground- and space-based GPS measurements into the state-of-the-art Global Assimilative Ionosphere Modeling (GAIM) software. As an outcome of the UNB and NASA research, new and innovative GPS applications have been invented including the use of ionospheric measurements to detect tiny fluctuations in the GPS signals between the spacecraft and GPS receivers caused by natural hazards occurring on or near the Earth's surface.We will show examples for early detection of natural hazards generated ionospheric signatures using ground-based and space-borne GPS receivers. We will also discuss recent results from the U.S. Real-time Earthquake Analysis for Disaster Mitigation Network (READI) exercises utilizing our algorithms. By studying the propagation properties of ionospheric perturbations generated by natural hazards along with applying sophisticated first-principles physics-based modeling, we are on track to develop new technologies that can potentially save human lives and minimize property damage. It is also expected that ionospheric monitoring of TEC perturbations might become an integral part of existing natural hazards warning systems.

  7. Extending and automating a Systems-Theoretic hazard analysis for requirements generation and analysis.

    SciTech Connect

    Thomas, John

    2012-05-01

    Systems Theoretic Process Analysis (STPA) is a powerful new hazard analysis method designed to go beyond traditional safety techniques - such as Fault Tree Analysis (FTA) - that overlook important causes of accidents like flawed requirements, dysfunctional component interactions, and software errors. While proving to be very effective on real systems, no formal structure has been defined for STPA and its application has been ad-hoc with no rigorous procedures or model-based design tools. This report defines a formal mathematical structure underlying STPA and describes a procedure for systematically performing an STPA analysis based on that structure. A method for using the results of the hazard analysis to generate formal safety-critical, model-based system and software requirements is also presented. Techniques to automate both the analysis and the requirements generation are introduced, as well as a method to detect conflicts between the safety and other functional model-based requirements during early development of the system.

  8. Hazardous medical waste generation rates of different categories of health-care facilities.

    PubMed

    Komilis, Dimitrios; Fouki, Anastassia; Papadopoulos, Dimitrios

    2012-07-01

    Goal of this work was to calculate the hazardous medical waste unit generation rates (HMWUGR), in kg bed(-1)d(-1), using data from 132 health-care facilities in Greece. The calculations were based on the weights of the hazardous medical wastes that were regularly transferred to the sole medical waste incinerator in Athens over a 22-month period during years 2009 and 2010. The 132 health-care facilities were grouped into public and private ones, and, also, into seven sub-categories, namely: birth, cancer treatment, general, military, pediatric, psychiatric and university hospitals. Results showed that there is a large variability in the HMWUGR, even among hospitals of the same category. Average total HMWUGR varied from 0.012 kg bed(-1)d(-1), for the public psychiatric hospitals, to up to 0.72 kg bed(-1)d(-1), for the public university hospitals. Within the private hospitals, average HMWUGR ranged from 0.0012 kg bed(-1)d(-1), for the psychiatric clinics, to up to 0.49 kg bed(-1)d(-1), for the birth clinics. Based on non-parametric statistics, HMWUGR were statistically similar for the birth and general hospitals, in both the public and private sector. The private birth and general hospitals generated statistically more wastes compared to the corresponding public hospitals. The infectious/toxic and toxic medical wastes appear to be 10% and 50% of the total hazardous medical wastes generated by the public cancer treatment and university hospitals, respectively.

  9. Measurements in 80- by 120-foot wind tunnel of hazard posed by lift-generated wakes

    NASA Technical Reports Server (NTRS)

    Rossow, V. J.; Sacco, J. N.; Askins, P. A.; Bisbee, L. S.; Smith, S. M.

    1993-01-01

    The large, low speed wind tunnel at NASA-Ames has been used to study the characteristics of lift-generated vortices involved in the definition of aircraft-separation criteria, in order to enhance airport capacity without compromising safety. Attention is given to the potential hazard caused by the vortex wake of several configurations of a subsonic transport. Measured downwash distributions in the wake of three different wake-generator configurations are obtained by means of a vortex-lattice method, in order to predict the lift and rolling moment on several models of wake-following aircraft.

  10. The application of multiple instruction retry to VLIW architectures using compiler generated hazard-free code

    NASA Technical Reports Server (NTRS)

    Chen, Shyh-Kwei; Fuchs, W. K.; Hwu, Wen-Mei W.

    1993-01-01

    In this paper, we describe the development of compiler assisted multiple instruction word retry for VLIW architectures. Compiler generated hazard-free code with different degrees of rollback capability is compacted by a trace scheduling algorithm. Performances are compared under three parameters: N, the rollback distance for uni-processors; P, the number of functional units; and Np, the rollback distance for VLIW architectures. In the majority of benchmarks examined, for fixed P and Np, the larger N tends to generate compacted code with better performance.

  11. The National Shipbuilding Research Program. Environmental Training Modules. Module 8 - Generation/Treatment/Minimization of Hazardous Waste

    DTIC Science & Technology

    1999-05-01

    facility that generates 1,000 kilograms (2,200 lbs) or more per month. The federal hazardous waste regulations also recognize other smaller categories of...training is the first step to both ensuring compliance with the hazardous waste regulations , as well as facility and worker safety. Training for the...buildings, and waste container marking and labeling requirements. Subpart D - Recordkeeping and Reporting: The hazardous waste regulations require that a

  12. 76 FR 17414 - Agency Information Collection Activities; Proposed Collection; Comment Request; 2011 Hazardous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-29

    ... Waste Report, Notification of Regulated Waste Activity, and Part A Hazardous Waste Permit Application... collection. In addition, EPA is requesting comments on some proposed changes to the Hazardous Waste Report... Hazardous Waste Report From and Instructions booklet in the docket for this notice. What should I...

  13. Review and perspectives: Understanding natural-hazards-generated ionospheric perturbations using GPS measurements and coupled modeling

    NASA Astrophysics Data System (ADS)

    Komjathy, Attila; Yang, Yu-Ming; Meng, Xing; Verkhoglyadova, Olga; Mannucci, Anthony J.; Langley, Richard B.

    2016-07-01

    Natural hazards including earthquakes, volcanic eruptions, and tsunamis have been significant threats to humans throughout recorded history. Global navigation satellite systems (GNSS; including the Global Positioning System (GPS)) receivers have become primary sensors to measure signatures associated with natural hazards. These signatures typically include GPS-derived seismic deformation measurements, coseismic vertical displacements, and real-time GPS-derived ocean buoy positioning estimates. Another way to use GPS observables is to compute the ionospheric total electron content (TEC) to measure, model, and monitor postseismic ionospheric disturbances caused by, e.g., earthquakes, volcanic eruptions, and tsunamis. In this paper, we review research progress at the Jet Propulsion Laboratory and elsewhere using examples of ground-based and spaceborne observation of natural hazards that generated TEC perturbations. We present results for state-of-the-art imaging using ground-based and spaceborne ionospheric measurements and coupled atmosphere-ionosphere modeling of ionospheric TEC perturbations. We also report advancements and chart future directions in modeling and inversion techniques to estimate tsunami wave heights and ground surface displacements using TEC measurements and error estimates. Our initial retrievals strongly suggest that both ground-based and spaceborne GPS remote sensing techniques could play a critical role in detection and imaging of the upper atmosphere signatures of natural hazards including earthquakes and tsunamis. We found that combining ground-based and spaceborne measurements may be crucial in estimating critical geophysical parameters such as tsunami wave heights and ground surface displacements using TEC observations. The GNSS-based remote sensing of natural-hazard-induced ionospheric disturbances could be applied to and used in operational tsunami and earthquake early warning systems.

  14. GHRC: NASAs Hazardous Weather Distributed Active Archive Center

    NASA Technical Reports Server (NTRS)

    Ramachandran, Rahul; Bugbee, Kaylin

    2016-01-01

    The Global Hydrology Resource Center (GHRC; ghrc.nsstc.nasa.gov) is one of NASA's twelve Distributed Active Archive Centers responsible for providing access to NASA's Earth science data to users worldwide. Each of NASA's twelve DAACs focuses on a specific science discipline within Earth science, provides data stewardship services and supports its research community's needs. Established in 1991 as the Marshall Space Flight Center DAAC and renamed GHRC in 1997, the data center's original mission focused on the global hydrologic cycle. However, over the years, data holdings, tools and expertise of GHRC have gradually shifted. In 2014, a User Working Group (UWG) was established to review GHRC capabilities and provide recommendations to make GHRC more responsive to the research community's evolving needs. The UWG recommended an update to the GHRC mission, as well as a strategic plan to move in the new direction. After a careful and detailed analysis of GHRC's capabilities, research community needs and the existing data landscape, a new mission statement for GHRC has been crafted: to provide a comprehensive active archive of both data and knowledge augmentation services with a focus on hazardous weather, its governing dynamical and physical processes, and associated applications. Within this broad mandate, GHRC will focus on lightning, tropical cyclones and storm-induced hazards through integrated collections of satellite, airborne, and in-situ data sets. The new mission was adopted at the recent 2015 UWG meeting. GHRC will retain its current name until such time as it has built substantial data holdings aligned with the new mission.

  15. Landslide-Generated Tsunami Hazards in Fiordland, New Zealand and Norway

    NASA Astrophysics Data System (ADS)

    Dykstra, J. L.

    2009-05-01

    Sub-aerial or submarine landslides can generate large displacement waves, sometimes with devastating consequences. Catastrophic rockslides fall into the fiords of western Norway about every 100 years: during the last century, 174 people have been killed by landslide-generated tsunami, including the 1934 Tafjord rockslide which generated a 62 m high wave, killing 41 people. Hazard evaluation for the Norwegian fiords is based on high-resolution sonar imagery of landslide deposits, seismic reflection data, and event chronology developed from radiocarbon and surface exposure dating. The ongoing hazard is managed by identifying and monitoring potential failure areas, calculating slide paths and estimating slide properties at the points of impact. High-risk locations are monitored intensively, and include the Aknes slide area on Geirangerjord which could generate a tsunami of up to 30 m in height, and the Akernes landslide above Storfjorden. The current system of hazard evaluation and mitigation in western Norway is effective because large landslides are normally preceded by smaller rockfalls and by accelerating motion of the rock bodies. By contrast, large landslides in the very similar but highly seismic terrain of Fiordland, southwestern New Zealand are most likely earthquake-initiated, and therefore precursory minor rockfalls are unlikely. Coseismic landslides are common in New Zealand; seismic shaking serves as the primary trigger for failures that are preconditioned by progressive degradation of rock mass strength since deglaciation. The seismicity of Fiordland is dominated by the plate-boundary Alpine Fault, which runs immediately offshore of the popular tourist destination of Milford Sound; it has ruptured at least four times in the past 1000 years (the last time around 1717 A.D.) producing earthquakes of about magnitude 8. The probability of an earthquake of similar magnitude occurring along the Alpine Fault within the next 50 years is estimated at 65% plus

  16. Hazardous medical waste generation rates of different categories of health-care facilities

    SciTech Connect

    Komilis, Dimitrios; Fouki, Anastassia; Papadopoulos, Dimitrios

    2012-07-15

    Highlights: Black-Right-Pointing-Pointer We calculated hazardous medical waste generation rates (HMWGR) from 132 hospitals. Black-Right-Pointing-Pointer Based on a 22-month study period, HMWGR were highly skewed to the right. Black-Right-Pointing-Pointer The HMWGR varied from 0.00124 to 0.718 kg bed{sup -1} d{sup -1}. Black-Right-Pointing-Pointer A positive correlation existed between the HMWGR and the number of hospital beds. Black-Right-Pointing-Pointer We used non-parametric statistics to compare rates among hospital categories. - Abstract: Goal of this work was to calculate the hazardous medical waste unit generation rates (HMWUGR), in kg bed{sup -1} d{sup -1}, using data from 132 health-care facilities in Greece. The calculations were based on the weights of the hazardous medical wastes that were regularly transferred to the sole medical waste incinerator in Athens over a 22-month period during years 2009 and 2010. The 132 health-care facilities were grouped into public and private ones, and, also, into seven sub-categories, namely: birth, cancer treatment, general, military, pediatric, psychiatric and university hospitals. Results showed that there is a large variability in the HMWUGR, even among hospitals of the same category. Average total HMWUGR varied from 0.012 kg bed{sup -1} d{sup -1}, for the public psychiatric hospitals, to up to 0.72 kg bed{sup -1} d{sup -1}, for the public university hospitals. Within the private hospitals, average HMWUGR ranged from 0.0012 kg bed{sup -1} d{sup -1}, for the psychiatric clinics, to up to 0.49 kg bed{sup -1} d{sup -1}, for the birth clinics. Based on non-parametric statistics, HMWUGR were statistically similar for the birth and general hospitals, in both the public and private sector. The private birth and general hospitals generated statistically more wastes compared to the corresponding public hospitals. The infectious/toxic and toxic medical wastes appear to be 10% and 50% of the total hazardous medical wastes

  17. PyBetVH: A Python tool for probabilistic volcanic hazard assessment and for generation of Bayesian hazard curves and maps

    NASA Astrophysics Data System (ADS)

    Tonini, Roberto; Sandri, Laura; Anne Thompson, Mary

    2015-06-01

    PyBetVH is a completely new, free, open-source and cross-platform software implementation of the Bayesian Event Tree for Volcanic Hazard (BET_VH), a tool for estimating the probability of any magmatic hazardous phenomenon occurring in a selected time frame, accounting for all the uncertainties. New capabilities of this implementation include the ability to calculate hazard curves which describe the distribution of the exceedance probability as a function of intensity (e.g., tephra load) on a grid of points covering the target area. The computed hazard curves are (i) absolute (accounting for the probability of eruption in a given time frame, and for all the possible vent locations and eruptive sizes) and (ii) Bayesian (computed at different percentiles, in order to quantify the epistemic uncertainty). Such curves allow representation of the full information contained in the probabilistic volcanic hazard assessment (PVHA) and are well suited to become a main input to quantitative risk analyses. PyBetVH allows for interactive visualization of both the computed hazard curves, and the corresponding Bayesian hazard/probability maps. PyBetVH is designed to minimize the efforts of end users, making PVHA results accessible to people who may be less experienced in probabilistic methodologies, e.g. decision makers. The broad compatibility of Python language has also allowed PyBetVH to be installed on the VHub cyber-infrastructure, where it can be run online or downloaded at no cost. PyBetVH can be used to assess any type of magmatic hazard from any volcano. Here we illustrate how to perform a PVHA through PyBetVH using the example of analyzing tephra fallout from the Okataina Volcanic Centre (OVC), New Zealand, and highlight the range of outputs that the tool can generate.

  18. Payment Of the New Mexico Environment Department- Hazardous Waste Bureau Annual Business and Generation Fees Calendar Year 2011

    SciTech Connect

    Juarez, Catherine L.

    2012-08-31

    The purpose of this letter is to transmit to the New Mexico Environment Department-Hazardous Waste Bureau (NMED-HWB), the Los alamos National Laboratory (LANL) Annual Business and Generation Fees for calendar year 2011. These fees are required pursuant to the provisions of New Mexico Hazardous Waste Act, Chapter 74, Article 4, NMSA (as amended). The Laboratory's Fenton Hill Facility did not generate any hazardous waste during the entire year, and is not required to pay a fee for calendar year 2011. The enclosed fee represents the amount for a single facility owned by the Department of Energy and co-operated by the Los Alamos National Security, LLC (LANS).

  19. HAZ-ED Classroom Activities for Understanding Hazardous Waste.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    The Federal Superfund Program investigates and cleans up hazardous waste sites throughout the United States. Part of this program is devoted to informing the public and involving people in the process of cleaning up hazardous waste sites from beginning to end. The Haz-Ed program was developed to assist the Environmental Protection Agency's (EPA)…

  20. Site-specific Earthquake-generate Tsunami Hazard Assessment in U.S. Atlantic Coast

    NASA Astrophysics Data System (ADS)

    Wei, Y.; Titov, V. V.; Moore, C. W.; Gica, E.; Arcas, D.; Spillane, M. C.; Zhou, H.

    2009-12-01

    The Indian Ocean tsunami of 24 December 2004 has changed the perception of a tsunami as an infrequent low-risk hazard. The devoid of subduction or convergent zones in the Atlantic Ocean makes coastal communities less aware of the potential tsunami hazard in the East Coast of US. The existing continental shelf offshore has believed to act as additional buffer that may significantly attenuate the tsunami impact to the U.S. Atlantic coast. However, the uncertainties are still substantial and need to be timely addressed: 1. the largest tsunami ever recorded in Atlantic, 1755 Lisbon, was understudied; 2. the Hispaniola-Puerto Rico-Lesser Antilles subduction zone - a Sumatra-Andaman type of trench - in the northeast of Caribbean is capable of generating catastrophic tsunami; 3. the South Sandwich Trench was mostly overlooked; and 4. most of previous studies tackling these issues did not surpass the linear tsunami propagation in the deep ocean for nonlinear tsunami inundation modeling in the coastal area. Using the established NOAA high-resolution tsunami inundation model, the present study explores above uncertainties and provides comprehensive modeling assessment of the potential earthquake-generated tsunami hazard for selected coastal communities in U.S. Atlantic coasts, with highlight on over-shelf tsunami wave dynamics. This study is an extension of the USGS evaluation of earthquake-tsunami impact in Atlantic (ten Brink et al., 2007; Barkan et al., 2009) in the light of the Nuclear Regulation Commission (NRC) efforts on tsunami risk assessment for existing and potential nuclear power plants in U. S. East Coast.

  1. Towards a new approach for generating probabilistic hazard maps for pyroclastic flows during lava dome eruptions.

    NASA Astrophysics Data System (ADS)

    Calder, E. S.; Pitman, B.; Wolpert, R.; Bayarri, S.; Spiller, E.; Berger, J.

    2009-05-01

    It is increasingly being understood that development of mathematical models of a geophysical phenomena, while a fundamental step, is only part of the process of modeling and predicting inundation limits for natural hazards. In this work we combine data from hundreds of observed pyroclastic flows at the Soufriere Hills Volcano, Montserrat, a geophysical flow model, and statistical modeling to derive a new methodology for generating probabilistic hazard maps. The initial step consists of estimating probabilities of inundation at particular discrete points of interest (e.g. airport and Plymouth). The methodology starts with a computer model of the geophysical process, in this case the TITAN2D model that has been developed for modeling geophysical mass flows. A key input to the computer model is the probability distribution for the initial volume and direction of the flows based on observed data. An important limitation is that for modeling purposes, the observations represent relatively scarce datasets, while from a volcanological perspective datasets such as those from the prolonged and relatively well-monitored eruption of the Soufriere Hills Volcano, are as complete as can be realistically obtained. By combining flow event data, probability modeling and statistical methods, a probability distribution of severity and frequency of flow events is derived. Understanding and predicting the effects of volcanic hazards involves understanding the extreme event tail (the largest flow events) but this is notoriously difficult, especially with the limited data and prohibitively expensive to compute.. Instead a statistical emulator (or surrogate of the computer model) is used, a computationally cheap response surface approximating the output of the flow simulations, which is constructed based on carefully chosen computer model runs. The speed of the emulator then allows to 'solve the inverse problem': that is, to determine regions of inputs values (characteristics of the flow

  2. Plasma destruction of North Carolina`s hazardous waste based on hazardous waste generated between the years of 1989 and 1992

    SciTech Connect

    Williams, Dwight LeRoi

    1994-01-01

    The purpose of this research is to analyze the applicability of the plasma waste destruction technology to North Carolina hazardous waste streams. This study outlines the current regulations, existing technologies, and innovative technologies being considered as hazardous waste treatment alternatives. From this foundation, the study proceeds to identify the superiority of the plasma waste destruction technology. Specific areas of discussion include: temperature capabilities, waste residence time requirements, destruction removal efficiencies, operational efficiencies, economic issues, safety, and maintenance. This study finds the plasma destruction technology to be fully effective and superior to conventional facilities. The technology completely destroys hydrocarbons and can reduce the volume of many other hazardous wastes on the order of one part per million. The required residence time of waste in a plasma facility for effective destruction is a fraction of a second, while the rotary kiln incinerator maintains an average residence time of approximately 5 seconds. Also mass and heat balance calculations are performed to quantify the effectiveness and efficiency of this technology. It is found that one day`s average amount of hazardous waste generated in the state of North Carolina can be destroyed in approximately thirty seconds using a standard one megawatt power source. Yet, before this technology is adopted as North Carolina`s primary hazardous waste destruction technology, further study is needed so that all issues considered in this research can be conducted in great detail.

  3. Treatment Technologies for Hazardous Ashes Generated from Possible Incineration of Navy Waste

    DTIC Science & Technology

    1990-10-01

    Hazardous and Solid Waste Amendments of 1984 HW - Hazardous Waste HWM - Hazardous Waste Minimization IWTP - Industrial wastewater treatment piant...Resource Conservation and Recovery Act of 1976 (RCRA) and the Hazardous and Solid Waste Amendments of 1984 (HSWA) will eventually prohibit land disposal of...Conservation and Recovery Act of 1976, as amended, PL 94-580, 42 USC 6901. 3. Hazardous and Solid Waste Amendments

  4. Fractal analysis of experimentally generated pyroclasts: A tool for volcanic hazard assessment

    NASA Astrophysics Data System (ADS)

    Perugini, Diego; Kueppers, Ulrich

    2012-06-01

    Rapid decompression experiments on natural volcanic rocks mimick explosive eruptions. Fragment size distributions (FSD) of such experimentally generated pyroclasts are investigated using fractal geometry. The fractal dimension of fragmentation, D, of FSD is measured for samples from Unzen (Japan) and Popocatépetl (Mexico) volcanoes. Results show that: (i) FSD are fractal and can be quantified by measuring D values; (ii) D increases linearly with potential energy for fragmentation (PEF) and, thus, with increasing applied pressure; (iii) the rate of increase of D with PEF depends on open porosity: the higher the open porosity, the lower the increase of D with PEF; (iv) at comparable open porosity, samples display a similar behavior for any rock composition. The method proposed here has the potential to become a standard routine to estimate eruptive energy of past and recent eruptions using values of D and open porosity, providing an important step towards volcanic hazard assessment.

  5. Hazard Analysis Database Report

    SciTech Connect

    GRAMS, W.H.

    2000-12-28

    The Hazard Analysis Database was developed in conjunction with the hazard analysis activities conducted in accordance with DOE-STD-3009-94, Preparation Guide for U S . Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, for HNF-SD-WM-SAR-067, Tank Farms Final Safety Analysis Report (FSAR). The FSAR is part of the approved Authorization Basis (AB) for the River Protection Project (RPP). This document describes, identifies, and defines the contents and structure of the Tank Farms FSAR Hazard Analysis Database and documents the configuration control changes made to the database. The Hazard Analysis Database contains the collection of information generated during the initial hazard evaluations and the subsequent hazard and accident analysis activities. The Hazard Analysis Database supports the preparation of Chapters 3 ,4 , and 5 of the Tank Farms FSAR and the Unreviewed Safety Question (USQ) process and consists of two major, interrelated data sets: (1) Hazard Analysis Database: Data from the results of the hazard evaluations, and (2) Hazard Topography Database: Data from the system familiarization and hazard identification.

  6. Information on Disposal Practices of Generators of Small Quantities of Hazardous Wastes.

    DTIC Science & Technology

    1983-09-28

    reviewed the States’ solid and hazardous waste regulations , policies, and procedures. We contacted solid or hazardous waste officials in 46 other States...exempts from hazardous waste regulations mixtures of domestic sewage and other wastes that pass through a sewer system to a publicly owned sewage...such wastes under hazardous waste regulations is necessary. An assistant to the EPA Assistant Administrator for Water said that EPA recognizes that a

  7. Closure of a hazardous waste disposal facility in an active oil field

    SciTech Connect

    Knott, S.A.; White, A.E. )

    1991-02-01

    State and federal laws and regulations enacted during the past five years have led to closure activities at a large number of hazardous waste disposal facilities. These closures are often lengthy, difficult, and expensive. Closures must adhere to federal regulations promulgated by the U.S. Environmental Protection Agency (EPA) as well as State regulations administered by the Department of Health Services and the Regional Water Quality Control Boards. This exhibit depicts the regulatory framework for closure of a hazardous waste site. It also describes the closure alternatives for a site in the Central Valley which primarily accepted wastes generated from oil field activities. Generally, one of two closure alternatives is followed: (1) sites are closed-in-place with the wastes covered or monitored, or (2) wastes are treated and removed so that no waste or waste residue remains. Regulations issued by the EPA in 1987 made another option available. This option is risk-based clean closure and involves the identification of risk-based cleanup goals. A site-specific risk assessment adhering to federal and state guidelines is required to establish the cleanup goals. Waste constituents present in concentrations below these goals may be left in place without post closure care.

  8. Project of Near-Real-Time Generation of ShakeMaps and a New Hazard Map in Austria

    NASA Astrophysics Data System (ADS)

    Jia, Yan; Weginger, Stefan; Horn, Nikolaus; Hausmann, Helmut; Lenhardt, Wolfgang

    2016-04-01

    Target-orientated prevention and effective crisis management can reduce or avoid damage and save lives in case of a strong earthquake. To achieve this goal, a project for automatic generated ShakeMaps (maps of ground motion and shaking intensity) and updating the Austrian hazard map was started at ZAMG (Zentralanstalt für Meteorologie und Geodynamik) in 2015. The first goal of the project is set for a near-real-time generation of ShakeMaps following strong earthquakes in Austria to provide rapid, accurate and official information to support the governmental crisis management. Using newly developed methods and software by SHARE (Seismic Hazard Harmonization in Europe) and GEM (Global Earthquake Model), which allows a transnational analysis at European level, a new generation of Austrian hazard maps will be ultimately calculated. More information and a status of our project will be given by this presentation.

  9. Active Metamaterial Based Terahertz Polarimeter for Spectroscopic Detection of Chemical and Biological Hazards

    DTIC Science & Technology

    2014-04-01

    Active Metamaterial Based Terahertz Polarimeter for Spectroscopic Detection of Chemical and Biological Hazards by Grace D. Metcalfe ...for Spectroscopic Detection of Chemical and Biological Hazards Grace D. Metcalfe and Michael Wraback Sensors and Electron Devices Directorate, ARL...GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Grace D. Metcalfe , Michael Wraback, Richard D. Averitt, and Xin Zhang 5d. PROJECT NUMBER

  10. Hazardous Waste: EPA’s Generation and Management Data Need Further Improvement

    DTIC Science & Technology

    1990-02-01

    Hazardous and Solid Waste Amendments of 1984 form the foundation for this...Superfund) EPA Environmental Protection Agency GAO General Accounting Office HSWA Hazardous and Solid Waste Amendments , 1984 NGA National Governors...to final disposition. The Hazardous and Solid Waste Amendments of 1984 (HswA) strengthened RCRA by further encouraging waste

  11. Natural hazards activities of the National Geophysical Data Center

    USGS Publications Warehouse

    Lockridge, P.A.

    1985-01-01

    The National Geophysical Data Center (NGDC), a part of the National Oceanic and Atmospheric Administration, has been given the task of collecting, managing, and disseminating the great mass of inofmation produced by scientific observations of the geophysical environment. This article describes NGDC data bases that speifically relate to natural hazards

  12. Activities for Teaching about Hazardous Materials in the Home.

    ERIC Educational Resources Information Center

    Howe, Robert W.; And Others

    Materials containing hazardous substances present serious problems to human health and to the health of the environment. There are many potential problems related to the site of a house or apartment, the construction materials used in the house or the apartment, products and materials used in and around the home, and disposal of materials.…

  13. CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III.

    PubMed

    Zanoni, Thalita Boldrin; Lizier, Thiago M; Assis, Marilda das Dores; Zanoni, Maria Valnice B; de Oliveira, Danielle Palma

    2013-07-01

    This work describes the mutagenic response of Sudan III, an adulterant food dye, using Salmonella typhimurium assay and the generation of hazardous aromatic amines after different oxidation methods of this azo dye. For that, we used metabolic activation by S9, catalytic oxidation by ironporphyrin and electrochemistry oxidation in order to simulate endogenous oxidation conditions. The oxidation reactions promoted discoloration from 65% to 95% of Sudan III at 1 × 10(-4)molL(-1) and generation of 7.6 × 10(-7)molL(-1) to 0.31 × 10(-4)molL(-1) of aniline, o-anisidine, 2-methoxi-5-methylaniline, 4-aminobiphenyl, 4,4'-oxydianiline; 4,4'-diaminodiphenylmethane and 2,6-dimethylaniline. The results were confirmed by LC-MS-MS experiments. We also correlate the mutagenic effects of Sudan III using S. typhimurium with the strain TA1535 in the presence of exogenous metabolic activation (S9) with the metabolization products of this compound. Our findings clearly indicate that aromatic amines are formed due to oxidative reactions that can be promoted by hepatic cells, after the ingestion of Sudan III. Considering that, the use of azo compounds as food dyestuffs should be carefully controlled.

  14. Hazardous medical waste generation in Greece: case studies from medical facilities in Attica and from a small insular hospital.

    PubMed

    Komilis, Dimitrios; Katsafaros, Nikolaos; Vassilopoulos, Panagiotis

    2011-08-01

    The accurate calculation of the unit generation rates and composition of medical waste generated from medical facilities is necessary in order to design medical waste treatment systems. In this work, the unit medical waste generation rates of 95 public and private medical facilities in the Attica region were calculated based on daily weight records from a central medical waste incineration facility. The calculated medical waste generation rates (in kg bed(-1) day( -1)) varied widely with average values at 0.27 ± 113% and 0.24 ± 121%, for public and private medical facilities, respectively. The hazardous medical waste generation was measured, at the source, in the 40 bed hospital of the island of Ikaria for a period of 42 days during a 6 month period. The average hazardous medical waste generation rate was 1.204 kg occupied bed(-1) day(-1) or 0.33 kg (official) bed( -1) day(-1). From the above amounts, 54% resulted from the patients' room (solid and liquid wastes combined), 24% from the emergency department (solid waste), 17% from the clinical pathology lab and 6% from the X-ray lab. In average, 17% of the total hazardous medical waste was solely infectious. Conclusively, no correlation among the number of beds and the unit medical waste generation rate could be established. Each hospital should be studied separately, since medical waste generation and composition depends on the number and type of departments/laboratories at each hospital, number of external patients and number of occupied beds.

  15. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b)...

  16. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b)...

  17. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b)...

  18. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b)...

  19. 40 CFR 260.41 - Procedures for case-by-case regulation of hazardous waste recycling activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of hazardous waste recycling activities. 260.41 Section 260.41 Protection of Environment... Rulemaking Petitions § 260.41 Procedures for case-by-case regulation of hazardous waste recycling activities... hazardous waste recycling activities described in § 261.6(a)(2)(iii) under the provisions of § 261.6 (b)...

  20. Combining SLBL routine with landslide-generated tsunami model for a quick hazard assessment tool

    NASA Astrophysics Data System (ADS)

    Franz, Martin; Rudaz, Benjamin; Jaboyedoff, Michel; Podladchikov, Yury

    2016-04-01

    Regions with steep topography are potentially subject to landslide-induced tsunami, because of the proximity between lakes, rivers, sea shores and potential instabilities. The concentration of the population and infrastructures on the water body shores and downstream valleys could lead to catastrophic consequences. In order to assess comprehensively this phenomenon together with the induced risks, we have developed a tool which allows the construction of the landslide geometry, and which is able to simulate its propagation, the generation and the propagation of the wave and eventually the spread on the shores or the associated downstream flow. The tool is developed in the Matlab© environment, with a graphical user interface (GUI) to select the parameters in a user-friendly manner. The whole process is done in three steps implying different methods. Firstly, the geometry of the sliding mass is constructed using the Sloping Local Base Level (SLBL) concept. Secondly, the propagation of this volume is performed using a model based on viscous flow equations. Finally, the wave generation and its propagation are simulated using the shallow water equations stabilized by the Lax-Friedrichs scheme. The transition between wet and dry bed is performed by the combination of the two latter sets of equations. The intensity map is based on the criterion of flooding in Switzerland provided by the OFEG and results from the multiplication of the velocity and the depth obtained during the simulation. The tool can be used for hazard assessment in the case of well-known landslides, where the SLBL routine can be constrained and checked for realistic construction of the geometrical model. In less-known cases, various failure plane geometries can be automatically built between given range and thus a multi-scenario approach is used. In any case, less-known parameters such as the landslide velocity, its run-out distance, etc. can also be set to vary within given ranges, leading to multi

  1. Relative Hazard Calculation Methodology

    SciTech Connect

    DL Strenge; MK White; RD Stenner; WB Andrews

    1999-09-07

    The methodology presented in this document was developed to provide a means of calculating the RH ratios to use in developing useful graphic illustrations. The RH equation, as presented in this methodology, is primarily a collection of key factors relevant to understanding the hazards and risks associated with projected risk management activities. The RH equation has the potential for much broader application than generating risk profiles. For example, it can be used to compare one risk management activity with another, instead of just comparing it to a fixed baseline as was done for the risk profiles. If the appropriate source term data are available, it could be used in its non-ratio form to estimate absolute values of the associated hazards. These estimated values of hazard could then be examined to help understand which risk management activities are addressing the higher hazard conditions at a site. Graphics could be generated from these absolute hazard values to compare high-hazard conditions. If the RH equation is used in this manner, care must be taken to specifically define and qualify the estimated absolute hazard values (e.g., identify which factors were considered and which ones tended to drive the hazard estimation).

  2. Generating survival times to simulate Cox proportional hazards models with time-varying covariates.

    PubMed

    Austin, Peter C

    2012-12-20

    Simulations and Monte Carlo methods serve an important role in modern statistical research. They allow for an examination of the performance of statistical procedures in settings in which analytic and mathematical derivations may not be feasible. A key element in any statistical simulation is the existence of an appropriate data-generating process: one must be able to simulate data from a specified statistical model. We describe data-generating processes for the Cox proportional hazards model with time-varying covariates when event times follow an exponential, Weibull, or Gompertz distribution. We consider three types of time-varying covariates: first, a dichotomous time-varying covariate that can change at most once from untreated to treated (e.g., organ transplant); second, a continuous time-varying covariate such as cumulative exposure at a constant dose to radiation or to a pharmaceutical agent used for a chronic condition; third, a dichotomous time-varying covariate with a subject being able to move repeatedly between treatment states (e.g., current compliance or use of a medication). In each setting, we derive closed-form expressions that allow one to simulate survival times so that survival times are related to a vector of fixed or time-invariant covariates and to a single time-varying covariate. We illustrate the utility of our closed-form expressions for simulating event times by using Monte Carlo simulations to estimate the statistical power to detect as statistically significant the effect of different types of binary time-varying covariates. This is compared with the statistical power to detect as statistically significant a binary time-invariant covariate.

  3. Hazardous Waste Data (RCRAInfo)

    EPA Pesticide Factsheets

    Hazardous waste information is contained in the Resource Conservation and Recovery Act Information (RCRAInfo), a national program management and inventory system about hazardous waste handlers. In general, all generators, transporters, treaters, storers, and disposers of hazardous waste are required to provide information about their activities to state environmental agencies. These agencies, in turn pass on the information to regional and national EPA offices. This regulation is governed by the Resource Conservation and Recovery Act (RCRA), as amended by the Hazardous and Solid Waste Amendments of 1984. You may use the RCRAInfo Search to determine identification and location data for specific hazardous waste handlers, and to find a wide range of information on treatment, storage, and disposal facilities regarding permit/closure status, compliance with Federal and State regulations, and cleanup activities.

  4. Neutronics activities for next generation devices

    SciTech Connect

    Gohar, Y.

    1985-01-01

    Neutronic activities for the next generation devices are the subject of this paper. The main activities include TFCX and FPD blanket/shield studies, neutronic aspects of ETR/INTOR critical issues, and neutronics computational modules for the tokamak system code and tandem mirror reactor system code. Trade-off analyses, optimization studies, design problem investigations and computational models development for reactor parametric studies carried out for these activities are summarized.

  5. Digital data set of volcano hazards for active Cascade Volcanos, Washington

    USGS Publications Warehouse

    Schilling, Steve P.

    1996-01-01

    Scientists at the Cascade Volcano Observatory have completed hazard assessments for the five active volcanos in Washington. The five studies included Mount Adams (Scott and others, 1995), Mount Baker (Gardner and others, 1995), Glacier Peak (Waitt and others, 1995), Mount Rainier (Hoblitt and others, 1995) and Mount St. Helens (Wolfe and Pierson, 1995). Twenty Geographic Information System (GIS) data sets have been created that represent the hazard information from the assessments. The twenty data sets have individual Open File part numbers and titles

  6. Gasification characteristics of an activated carbon catalyst during the decomposition of hazardous waste material in supercritical water

    SciTech Connect

    Matsumura, Yukihiko; Nuessle, F.W.; Antal, M.J. Jr.

    1996-12-31

    Recently, carbonaceous materials including activated carbon were proven to be effective catalysts for hazardous waste gasification in supercritical water. Using coconut shell activated carbon catalyst, complete decomposition of industrial organic wastes including methanol and acetic acid was achieved. During this process, the total mass of the activated carbon catalyst changes by two competing processes: a decrease in weight via gasification of the carbon by supercritical water, or an increase in weight by deposition of carbonaceous materials generated by incomplete gasification of the biomass feedstocks. The deposition of carbonaceous materials does not occur when complete gasification is realized. Gasification of the activated carbon in supercritical water is often favored, resulting in changes in the quality and quantity of the catalyst. To thoroughly understand the hazardous waste decomposition process, a more complete understanding of the behavior of activated carbon in pure supercritical water is needed. The gasification rate of carbon by water vapor at subcritical pressures was studied in relation to coal gasification and generating activated carbon.

  7. Evaluation of seismic design spectrum based on UHS implementing fourth-generation seismic hazard maps of Canada

    NASA Astrophysics Data System (ADS)

    Ahmed, Ali; Hasan, Rafiq; Pekau, Oscar A.

    2016-12-01

    Two recent developments have come into the forefront with reference to updating the seismic design provisions for codes: (1) publication of new seismic hazard maps for Canada by the Geological Survey of Canada, and (2) emergence of the concept of new spectral format outdating the conventional standardized spectral format. The fourth -generation seismic hazard maps are based on enriched seismic data, enhanced knowledge of regional seismicity and improved seismic hazard modeling techniques. Therefore, the new maps are more accurate and need to incorporate into the Canadian Highway Bridge Design Code (CHBDC) for its next edition similar to its building counterpart National Building Code of Canada (NBCC). In fact, the code writers expressed similar intentions with comments in the commentary of CHBCD 2006. During the process of updating codes, NBCC, and AASHTO Guide Specifications for LRFD Seismic Bridge Design, American Association of State Highway and Transportation Officials, Washington (2009) lowered the probability level from 10 to 2% and 10 to 5%, respectively. This study has brought five sets of hazard maps corresponding to 2%, 5% and 10% probability of exceedance in 50 years developed by the GSC under investigation. To have a sound statistical inference, 389 Canadian cities are selected. This study shows the implications of the changes of new hazard maps on the design process (i.e., extent of magnification or reduction of the design forces).

  8. Ionospheric response to infrasonic-acoustic waves generated by natural hazard events

    NASA Astrophysics Data System (ADS)

    Zettergren, M. D.; Snively, J. B.

    2015-09-01

    Recent measurements of GPS-derived total electron content (TEC) reveal acoustic wave periods of ˜1-4 min in the F region ionosphere following natural hazard events, such as earthquakes, severe weather, and volcanoes. Here we simulate the ionospheric responses to infrasonic-acoustic waves, generated by vertical accelerations at the Earth's surface or within the lower atmosphere, using a compressible atmospheric dynamics model to perturb a multifluid ionospheric model. Response dependencies on wave source geometry and spectrum are investigated at middle, low, and equatorial latitudes. Results suggest constraints on wave amplitudes that are consistent with observations and that provide insight on the geographical variability of TEC signatures and their dependence on the geometry of wave velocity field perturbations relative to the ambient geomagnetic field. Asymmetries of responses poleward and equatorward from the wave sources indicate that electron perturbations are enhanced on the equatorward side while field aligned currents are driven principally on the poleward side, due to alignments of acoustic wave velocities parallel and perpendicular to field lines, respectively. Acoustic-wave-driven TEC perturbations are shown to have periods of ˜3-4 min, which are consistent with the fraction of the spectrum that remains following strong dissipation throughout the thermosphere. Furthermore, thermospheric acoustic waves couple with ion sound waves throughout the F region and topside ionosphere, driving plasma disturbances with similar periods and faster phase speeds. The associated magnetic perturbations of the simulated waves are calculated to be observable and may provide new observational insight in addition to that provided by GPS TEC measurements.

  9. Lahar hazard zones for eruption-generated lahars in the Lassen Volcanic Center, California

    USGS Publications Warehouse

    Robinson, Joel E.; Clynne, Michael A.

    2012-01-01

    lahar generation, we assume that the maximum historical water equivalent, 3.90 m, covers the entire basin area inside the H/L cone. The product of planimetric area of each basin inside the H/L and the maximum historical water equivalent yields the maximum water volume available to generate a lahar. We then double the water volumes to approximate maximum lahar volumes. The maximum lahar volumes and an understanding of the statistical uncertainties inherent to the LAHARZ calculations guided our selection of six hypothetical volumes, 1, 3, 10, 30, 60, and 90x106 m3, to delineate concentric lahar inundation zones. The lahar inundation zones extend, in general, tens of kilometers away from Lassen Peak. The small, more-frequent lahar inundation zones (1 and 3x106 m3) are, on average, 10 km long. The exceptions are the zones in Warner Creek and Mill Creek, which extend much further. All but one of the small, more-frequent lahar inundation zones reach outside of the Lassen Volcanic National Park boundary, and the zone in Mill Creek extends well past the park boundary. All of the medium, moderately frequent lahar inundation zones (10 and 30x106 m3) extend past the park boundary and could potentially impact the communities of Viola and Old Station and State Highways 36 and 44, both north and west of Lassen Peak. The approximately 27-km-long on average, large, less-frequent lahar inundation zones (60 and 90x106 m3) represent worst-case lahar scenarios that are unlikely to occur. Flood hazards continue downstream from the toes of the lahars, potentially affecting communities in the Sacramento River Valley.

  10. A Guidance Manual: Waste Analysis at Facilities that Generate, Treat, Store, and Dispose of Hazardous Wastes

    EPA Pesticide Factsheets

    Discusses how a person can perform waste analyses and develop waste analysis plans (WAPs) in accordance with the federal hazardous waste regulations of the Resource Conservation and Recovery Act (RCRA)

  11. Teamwork tools and activities within the hazard component of the Global Earthquake Model

    NASA Astrophysics Data System (ADS)

    Pagani, M.; Weatherill, G.; Monelli, D.; Danciu, L.

    2013-05-01

    The Global Earthquake Model (GEM) is a public-private partnership aimed at supporting and fostering a global community of scientists and engineers working in the fields of seismic hazard and risk assessment. In the hazard sector, in particular, GEM recognizes the importance of local ownership and leadership in the creation of seismic hazard models. For this reason, over the last few years, GEM has been promoting different activities in the context of seismic hazard analysis ranging, for example, from regional projects targeted at the creation of updated seismic hazard studies to the development of a new open-source seismic hazard and risk calculation software called OpenQuake-engine (http://globalquakemodel.org). In this communication we'll provide a tour of the various activities completed, such as the new ISC-GEM Global Instrumental Catalogue, and of currently on-going initiatives like the creation of a suite of tools for the creation of PSHA input models. Discussion, comments and criticism by the colleagues in the audience will be highly appreciated.

  12. Probabilistic seismic hazard study based on active fault and finite element geodynamic models

    NASA Astrophysics Data System (ADS)

    Kastelic, Vanja; Carafa, Michele M. C.; Visini, Francesco

    2016-04-01

    We present a probabilistic seismic hazard analysis (PSHA) that is exclusively based on active faults and geodynamic finite element input models whereas seismic catalogues were used only in a posterior comparison. We applied the developed model in the External Dinarides, a slow deforming thrust-and-fold belt at the contact between Adria and Eurasia.. is the Our method consists of establishing s two earthquake rupture forecast models: (i) a geological active fault input (GEO) model and, (ii) a finite element (FEM) model. The GEO model is based on active fault database that provides information on fault location and its geometric and kinematic parameters together with estimations on its slip rate. By default in this model all deformation is set to be released along the active faults. The FEM model is based on a numerical geodynamic model developed for the region of study. In this model the deformation is, besides along the active faults, released also in the volumetric continuum elements. From both models we calculated their corresponding activity rates, its earthquake rates and their final expected peak ground accelerations. We investigated both the source model and the earthquake model uncertainties by varying the main active fault and earthquake rate calculation parameters through constructing corresponding branches of the seismic hazard logic tree. Hazard maps and UHS curves have been produced for horizontal ground motion on bedrock conditions VS 30 ≥ 800 m/s), thereby not considering local site amplification effects. The hazard was computed over a 0.2° spaced grid considering 648 branches of the logic tree and the mean value of 10% probability of exceedance in 50 years hazard level, while the 5th and 95th percentiles were also computed to investigate the model limits. We conducted a sensitivity analysis to control which of the input parameters influence the final hazard results in which measure. The results of such comparison evidence the deformation model and

  13. Numerical Tsunami Hazard Assessment of the Only Active Lesser Antilles Arc Submarine Volcano: Kick 'em Jenny.

    NASA Astrophysics Data System (ADS)

    Dondin, F. J. Y.; Dorville, J. F. M.; Robertson, R. E. A.

    2015-12-01

    The Lesser Antilles Volcanic Arc has potentially been hit by prehistorical regional tsunamis generated by voluminous volcanic landslides (volume > 1 km3) among the 53 events recognized so far. No field evidence of these tsunamis are found in the vincity of the sources. Such a scenario taking place nowadays would trigger hazardous tsunami waves bearing potentially catastrophic consequences for the closest islands and regional offshore oil platforms.Here we applied a complete hazard assessment method on the only active submarine volcano of the arc Kick 'em Jenny (KeJ). KeJ is the southernmost edifice with recognized associated volcanic landslide deposits. From the three identified landslide episodes one is associated with a collapse volume ca. 4.4 km3. Numerical simulations considering a single pulse collapse revealed that this episode would have produced a regional tsunami. An edifice current volume estimate is ca. 1.5 km3.Previous study exists in relationship to assessment of regional tsunami hazard related to shoreline surface elevation (run-up) in the case of a potential flank collapse scenario at KeJ. However this assessment was based on inferred volume of collapse material. We aim to firstly quantify potential initial volumes of collapse material using relative slope instability analysis (RSIA); secondly to assess first order run-ups and maximum inland inundation distance for Barbados and Trinidad and Tobago, i.e. two important economic centers of the Lesser Antilles. In this framework we present for seven geomechanical models tested in the RSIA step maps of critical failure surface associated with factor of stability (Fs) for twelve sectors of 30° each; then we introduce maps of expected potential run-ups (run-up × the probability of failure at a sector) at the shoreline.The RSIA evaluates critical potential failure surface associated with Fs <1 as compared to areas of deficit/surplus of mass/volume identified on the volcanic edifice using (VolcanoFit 2

  14. Probabilistic seismic hazard at Mt. Etna (Italy): The contribution of local fault activity in mid-term assessment

    NASA Astrophysics Data System (ADS)

    Azzaro, R.; D'Amico, S.; Peruzza, L.; Tuvè, T.

    2013-02-01

    In this work, we tackle the problem of seismic hazard at Etna deriving from the recurrent seismogenic activity of local faults, by adopting two independent methods based on probabilistic approaches. We assess the hazard in terms of macroseismic intensity and represent the occurrence probability calculated for different exposure times both on maps and at fault scale. Seismic hazard maps obtained by applying the "site approach" through the SASHA code and a new probabilistic attenuation model, indicate the eastern flank of the volcano as the most hazardous, with expected intensity (Iexp) in 50 years (i.e. the standard exposure time adopted in the seismic regulations) ranging from degrees IX to X EMS. In shorter exposure periods (20, 10, 5 years), values of Iexp up to IX are also reached in the same area, but they are clearly determined by the earthquakes generated by the Timpe fault system. In order to quantify the contribution of local seismogenic sources to the hazard of the region, we reconstruct the seismic history of each fault and calculate with SASHA the probability that earthquakes of a given intensity may be generated in different exposure times. Results confirm the high level of hazard due to the S. Tecla, Moscarello and Fiandaca faults especially for earthquakes of moderate intensity, i.e. VI ≤ I0 ≤ VII, with probabilities respectively exceeding 50% and 20% in 10 years, and 30% and 10% in 5 years. Occurrence probability of major events (I0 ≥ VIII) at the fault scale has also been investigated by statistics on intertimes. Under stationary assumptions we obtain a probability of 6.8% in 5 years for each structure; by introducing the time-dependency (time elapsed since the last event occurred on each fault) through a BPT model, we identify the Moscarello and S. Tecla faults as the most probable sources to be activated in the next 5 years (2013-2017). This result may represent a useful indication to establish priority criteria for actions aimed at reducing

  15. Nanominerals, fullerene aggregates, and hazardous elements in coal and coal combustion-generated aerosols: An environmental and toxicological assessment.

    PubMed

    Saikia, Jyotilima; Narzary, Bardwi; Roy, Sonali; Bordoloi, Manobjyoti; Saikia, Prasenjit; Saikia, Binoy K

    2016-12-01

    Studies on coal-derived nanoparticles as well as nano-minerals are important in the context of the human health and the environment. The coal combustion-generated aerosols also affect human health and environmental quality aspects in any coal-fired station. In this study, the feed coals and their combustion-generated aerosols from coal-fired boilers of two tea industry facilities were investigated for the presence of nanoparticles/nano minerals, fullerene aggregates, and potentially hazardous elements (PHEs). The samples were characterized by using X-ray diffraction (XRD), Time-of-flight secondary ion mass spectroscopy (TOF-SIMS), High resolution-transmission electron microscopy/energy dispersive spectroscopy (HR-TEM/EDS) and Ultra Violet-visible spectroscopy (UV-Vis) to know their extent of environmental risks to the human health when present in coals and aerosols. The feed coals contain mainly clay minerals, whilst glass fragments, spinel, quartz, and other minerals occur in lesser quantities. The PM samples contain potentially hazardous elements (PHEs) like As, Pb, Cd and Hg. Enrichment factor of the trace elements in particulate matters (PMs) was calculated to determine their sources. The aerosol samples were also found to contain nanomaterials and ultrafine particles. The fullerene aggregates along with potentially hazardous elements were also detected in the aerosol samples. The cytotoxicity studies on the coal combustion-generated PM samples show their potential risk to the human health. This detailed investigation on the inter-relationship between the feed coals and their aerosol chemistry will be useful for understanding the extent of environmental hazards and related human health risk.

  16. Generativity as a Route to Active Ageing

    PubMed Central

    Kruse, Andreas; Schmitt, Eric

    2012-01-01

    We elucidate the significance of active ageing from an individual as well as from a societal perspective. Taking an individual perspective, maintaining activity in later years is linked to successful ageing because of empirical relationships to positive self-perception, satisfaction with life, and development of competences, whereas from a societal perspective, active ageing implies usage of older people's life competences as a human capital of society—a societal imperative, particularly in times of demographic change but also more basically substantiated in an ethics of responsibility, intergenerational solidarity, and generation equity. We focus on the psychological construct of generativity which is interpreted as an aspect of the philosophical-anthropological category of joint responsibility. Our own research in Mexico and the Baltic States supports the notion that maintaining access to the public sphere and active engagement for others is a more basic individual concern than a life-stages specific developmental task. We report background and results of a Dialogue Forum Project Funding, a research cooperation between our institute and the Foundation Remembrance, Responsibility, and Future aimed to improve generativity in Belarus, Russia, and Ukraine by implementing and supporting local initiatives offering opportunities for intergenerational dialogue. PMID:22919378

  17. Asia-Pacific Region Global Earthquake and Volcanic Eruption Risk Management (G-EVER) project and a next-generation real-time volcano hazard assessment system

    NASA Astrophysics Data System (ADS)

    Takarada, S.

    2012-12-01

    The first Workshop of Asia-Pacific Region Global Earthquake and Volcanic Eruption Risk Management (G-EVER1) was held in Tsukuba, Ibaraki Prefecture, Japan from February 23 to 24, 2012. The workshop focused on the formulation of strategies to reduce the risks of disasters worldwide caused by the occurrence of earthquakes, tsunamis, and volcanic eruptions. More than 150 participants attended the workshop. During the workshop, the G-EVER1 accord was approved by the participants. The Accord consists of 10 recommendations like enhancing collaboration, sharing of resources, and making information about the risks of earthquakes and volcanic eruptions freely available and understandable. The G-EVER Hub website (http://g-ever.org) was established to promote the exchange of information and knowledge among the Asia-Pacific countries. Several G-EVER Working Groups and Task Forces were proposed. One of the working groups was tasked to make the next-generation real-time volcano hazard assessment system. The next-generation volcano hazard assessment system is useful for volcanic eruption prediction, risk assessment, and evacuation at various eruption stages. The assessment system is planned to be developed based on volcanic eruption scenario datasets, volcanic eruption database, and numerical simulations. Defining volcanic eruption scenarios based on precursor phenomena leading up to major eruptions of active volcanoes is quite important for the future prediction of volcanic eruptions. Compiling volcanic eruption scenarios after a major eruption is also important. A high quality volcanic eruption database, which contains compilations of eruption dates, volumes, and styles, is important for the next-generation volcano hazard assessment system. The volcanic eruption database is developed based on past eruption results, which only represent a subset of possible future scenarios. Hence, different distributions from the previous deposits are mainly observed due to the differences in

  18. Towards identifying the next generation of superfund and hazardous waste site contaminants

    USGS Publications Warehouse

    Ela, Wendell P.; Sedlak, David L.; Barlaz, Morton A.; Henry, Heather F.; Muir, Derek C.G.; Swackhamer, Deborah L.; Weber, Eric J.; Arnold, Robert G.; Ferguson, P. Lee; Field, Jennifer A.; Furlong, Edward T.; Giesy, John P.; Halden, Rolf U.; Henry, Tala; Hites, Ronald A.; Hornbuckle, Keri C.; Howard, Philip H.; Luthy, Richard G.; Meyer, Anita K.; Saez, A. Eduardo; vom Saal, Frederick S.; Vulpe, Chris D.; Wiesner, Mark R.

    2011-01-01

    Conclusions A need exists for a carefully considered and orchestrated expansion of programmatic and research efforts to identify, evaluate, and manage CECs of hazardous waste site relevance, including developing an evolving list of priority CECs, intensifying the identification and monitoring of likely sites of present or future accumulation of CECs, and implementing efforts that focus on a holistic approach to prevention.

  19. Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances.

    PubMed

    Parrott, Joanne L; Bjerregaard, Poul; Brugger, Kristin E; Gray, L Earl; Iguchi, Taisen; Kadlec, Sarah M; Weltje, Lennart; Wheeler, James R

    2017-03-01

    Endocrine-disrupting substances (EDS) may have certain biological effects including delayed effects, multigenerational effects, and may display nonmonotonic dose-response (NMDR) relationships that require careful consideration when determining environmental hazards. Endocrine disrupting substances can have specific and profound effects when exposure occurs during sensitive windows of the life cycle (development, reproduction). This creates the potential for delayed effects that manifest when exposure has ceased, possibly in a different life stage. This potential underscores the need for testing in appropriate (sensitive) life stages and full life cycle designs. Such tests are available in the Organisation for Economic Co-operation and Development (OECD) tool box and should be used to derive endpoints that can be considered protective of all life stages. Similarly, the potential for effects to be manifest in subsequent generations (multigenerational effects) has also been raised as a potential issue in the derivation of appropriate endpoints for EDS. However, multigenerational studies showing increasing sensitivity of successive generations are uncommon. Indeed this is reflected in the design of new higher tier tests to assess endocrine active substances (EAS) that move to extended one-generation designs and away from multi-generational studies. The occurrence of NMDRs is also considered a limiting factor for reliable risk assessment of EDS. Evidence to date indicates NMDRs are more prevalent in in vitro and mechanistic data, not often translating to adverse apical endpoints that would be used in risk assessment. A series of steps to evaluate NMDRs in the context of endocrine hazard and risk assessment procedures is presented. If careful consideration of delayed, multigenerational effects and NMDRs is made, it is feasible to assess environmental endocrine hazards and derive robust apical endpoints for risk assessment procedures ensuring a high level of environmental

  20. Hazard of electrostatic generation in a pneumatic conveying system: electrostatic effects on the accuracy of electrical capacitance tomography measurements and generation of spark

    NASA Astrophysics Data System (ADS)

    Zhang, Yan; Chii Liang, Yung; Wang, Chi-Hwa

    2008-01-01

    The study of the hazard of electrostatic generation in pneumatic conveying systems was attempted by examining the sensitivity of electrical capacitance tomography (ECT) and the phenomena of spark generation due to strong electrostatics. The influence on ECT measurement accuracy of an electrostatic charge was analysed with reference to a switch capacitor configuration model. Consequently, it was found that the electrostatic charge introduced at the bend with sharp angles influenced the ECT results most significantly in pneumatic conveying systems, especially for the cases where a spark was generated. The investigation of spark generation indicated that a strong electrostatic charge can cause major discharges inside or outside the pipeline to damage the experimental instrument in severe cases.

  1. Modeling Lahar Hazard Zones for Eruption-Generated Lahars from Lassen Peak, California

    NASA Astrophysics Data System (ADS)

    Robinson, J. E.; Clynne, M. A.

    2010-12-01

    Lassen Peak, a high-elevation, seasonally snow-covered peak located within Lassen Volcanic National Park, has lahar deposits in several drainages that head on or near the lava dome. This suggests that these drainages are susceptible to future lahars. The majority of the recognized lahar deposits are related to the May 19 and 22, 1915 eruptions of Lassen Peak. These small-volume eruptions generated lahars and floods when an avalanche of snow and hot rock, and a pyroclastic flow moved across the snow-covered upper flanks of the lava dome. Lahars flowed to the north down Lost Creek and Hat Creek. In Lost Creek, the lahars flowed up to 16 km downstream and deposited approximately 8.3 x 106 m3 of sediment. This study uses geologic mapping of the 1915 lahar deposits as a guide for LAHARZ modeling to assist in the assessment of present-day susceptibility for lahars in drainages heading on Lassen Peak. The LAHARZ model requires a Height over Length (H/L) energy cone controlling the initiation point of a lahar. We chose a H/L cone with a slope of 0.3 that intersects the earth’s surface at the break in slope at the base of the volcanic dome. Typically, the snow pack reaches its annual maximum by May. Average and maximum May snow-water content, a depth of water equal to 2.1 m and 3.5 m respectively, were calculated from a local snow gauge. A potential volume for individual 1915 lahars was calculated using the deposit volume, the snow-water contents, and the areas stripped of snow by the avalanche and pyroclastic flow. The calculated individual lahars in Lost Creek ranged in size from 9 x 106 m3 to 18.4 x 106 m3. These volumes modeled in LAHARZ matched the 1915 lahars remarkably well, with the modeled flows ending within 4 km of the mapped deposits. We delineated six drainage basins that head on or near Lassen Peak with the highest potential for lahar hazards: Lost Creek, Hat Creek, Manzanita Creek, Mill Creek, Warner Creek, and Bailey Creek. We calculated the area of each

  2. Guidelines for generators of hazardous chemical waste at LBL and guidelines for generators of radioactive and mixed waste at LBL. Revision 1

    SciTech Connect

    Not Available

    1991-09-01

    In part one of this document the Governing Documents and Definitions sections provide general guidelines and regulations applying to the handling of hazardous chemical wastes. The remaining sections provide details on how you can prepare your waste properly for transport and disposal. They are correlated with the steps you must take to properly prepare your waste for pickup. The purpose of the second part of this document is to provide the acceptance criteria for the transfer of radioactive and mixed waste to LBL`s Hazardous Waste Handling Facility (HWHF). These guidelines describe how you, as a generator of radioactive or mixed waste, can meet LBL`s acceptance criteria for radioactive and mixed waste.

  3. Safe Active Play: A Guide to Avoiding Play Area Hazards. [Videotape.

    ERIC Educational Resources Information Center

    1997

    Active play provides healthy exercise and allows children to test their skills against challenges in their environment, but when play results in even minor injury, it may be taking place in a hazardous setting. This video is designed to teach caregivers, child care program staff and recreation officials how to create safe play environments. Based…

  4. Recommended approaches to the scientific evaluation of environmental hazards and risks of endocrine-active substances

    EPA Science Inventory

    A SETAC Pellston Workshop™ ?‘Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)’ was held from 31st January to 5th February 2016 in Pensacola, Florida, USA. The primary aim of the workshop was to provide objective advice, ...

  5. Potential exposure to hazardous work activities: tractor usage among farmwomen.

    PubMed

    Carruth, Ann K; Skarke, Lana; Gilmore, Karen; Brown, Elizabeth R

    2006-01-01

    Farmwomen are often an unacknowledged workforce, leading to a lack of targeted safety interventions. This study examined the involvement and work patterns of 665 women in Texas and 657 women in Louisiana who were 18 years old and older and whose family participated in farming operations. Surveys were used to gather specific data regarding tractor work patterns, tractor knowledge, sources of information about tractors, and demographic information in two southern states in which cattle and dairy were the major agricultural commodity. Among the sample of 1,322 women, 577 (43.6%) reported driving tractors at least one day a year. This subset was used to describe characteristics of tractors and tractor-related activities. Findings indicate that women learn to drive tractors in their 20s, use husbands as the primary source of their information about tractors, engage in a wide variety of farm activities including bush-hogging and plowing, and acknowledge knowing an average or less than an average amount about driving tractors. Women most often reported driving between 1 to 12 days/year (n = 321, 55.6%). When examining patterns of ROPS-equipped tractor use, women were 1.47 times more likely to drive a tractor without ROPS or enclosed when driving less than 12 days a year as opposed to 13-103 days/year or greater than 104 days/year. The results of this study support the need for health care professionals and safety specialists to design appropriate interventions that target women to become more knowledgeable regarding the injury risks associated with farm work while driving tractors.

  6. Stabilization/solidification of hazardous and radioactive wastes with alkali-activated cements.

    PubMed

    Shi, Caijun; Fernández-Jiménez, A

    2006-10-11

    This paper reviews progresses on the use of alkali-activated cements for stabilization/solidification of hazardous and radioactive wastes. Alkali-activated cements consist of an alkaline activator and cementing components, such as blast furnace slag, coal fly ash, phosphorus slag, steel slag, metakaolin, etc., or a combination of two or more of them. Properly designed alkali-activated cements can exhibit both higher early and later strengths than conventional portland cement. The main hydration product of alkali-activated cements is calcium silicate hydrate (CSH) with low Ca/Si ratios or aluminosilicate gel at room temperature; CSH, tobmorite, xonotlite and/or zeolites under hydrothermal condition, no metastable crystalline compounds such as Ca(OH)(2) and calcium sulphoaluminates exist. Alkali-activated cements also exhibit excellent resistance to corrosive environments. The leachability of contaminants from alkali-activated cement stabilized hazardous and radioactive wastes is lower than that from hardened portland cement stabilized wastes. From all these aspects, it is concluded that alkali-activated cements are better matrix for solidification/stabilization of hazardous and radioactive wastes than Portland cement.

  7. Preface: Special Session SpS7 The impact hazard: current activities and future plans

    NASA Astrophysics Data System (ADS)

    Montmerle, Thierry

    2015-03-01

    In 2012, at the time of the Beijing GA, two decades had passed since the publication of the Spaceguard Report. Time has not passed in vain for the subject of NEO-related hazards, and we are currently in a totally different situation than in the early nineties. The amount of work done, and the level of awareness of the underlying problems, have both risen to such a level that a re-assessment by the astronomical community of its rôle and involvement was in order, and the GA Special Session 7 ``The impact hazard: current activities and future plans'' was aimed exactly at that.

  8. Safety Design Requirements for Active Hazard Mitigation Device (AHMD) Employed to Address Fast and Slow Cook-off Thermal Threats

    DTIC Science & Technology

    2014-12-18

    Hazard Mitigation Device (AHMD) Employed to Address Fast and Slow Cook-off Thermal Threats 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...environments. 15. SUBJECT TERMS Active Hazard Mitigation Device insensitive munitions fast cook-off slow...DESIGN REQUIREMENTS FOR ACTIVE HAZARD MITIGATION DEVICE (AHMD) EMPLOYED TO ADDRESS FAST AND SLOW COOK-OFF THERMAL THREATS DOD Fuze Engineering

  9. Swim pressure: stress generation in active matter.

    PubMed

    Takatori, S C; Yan, W; Brady, J F

    2014-07-11

    We discover a new contribution to the pressure (or stress) exerted by a suspension of self-propelled bodies. Through their self-motion, all active matter systems generate a unique swim pressure that is entirely athermal in origin. The origin of the swim pressure is based upon the notion that an active body would swim away in space unless confined by boundaries-this confinement pressure is precisely the swim pressure. Here we give the micromechanical basis for the swim stress and use this new perspective to study self-assembly and phase separation in active soft matter. The swim pressure gives rise to a nonequilibrium equation of state for active matter with pressure-volume phase diagrams that resemble a van der Waals loop from equilibrium gas-liquid coexistence. Theoretical predictions are corroborated by Brownian dynamics simulations. Our new swim stress perspective can help analyze and exploit a wide class of active soft matter, from swimming bacteria to catalytic nanobots to molecular motors that activate the cellular cytoskeleton.

  10. Hazard assessment for a submarine landslide generated local-source tsunami from Kaikoura Canyon

    NASA Astrophysics Data System (ADS)

    DuBois, J.

    2012-04-01

    The Kaikoura Canyon, sediment sink for the Canterbury rivers north of Christchurch, comes to within 500 meters of shore at Goose Bay and accumulates approximately 1.5x106 m3 of sediment each year (Lewis and Barnes, 1999). This sediment, which has accumulated to about seventy meters in thickness (Walters et al., 2006), exhibits tensional fractures, is located in a tectonically active area and could result in catastrophic failure and potentially a local-source tsunami (Lewis and Banes, 1999; Lewis, 1998; Walters et al, 2006). Evidence suggests that this may have happened in the last two hundred years (Lewis, 1998; Lewis and Barnes 1999) and with a return period on the nearby Alpine and Hope faults also in the range of a one to two hundred years (Walters et al, 2006) could happen again relatively soon. A review of the historical record and oral traditions for Kaikoura shows that historically Kaikoura has been affected by 11 events of which 10 are from distant sources and one, though debatable, is possibly from a local source. There are some preserved traditions for the Kaikoura area. These taniwha stories from near Oaro and from the Lyell Creek have been repeated and changed though time though the general essence remains the same. These taniwha legends, though not conclusive, indicate a dangerous shoreline where people have been killed in the past, possibly by flooding or tsunami. Archaeological investigations at Kaikoura found evidence of a Maori occupational layers interrupted by water-worn stones, a "lens of clean gravel between occupation layers" and in other areas of the excavation, the gravels separate discontinuous periods of occupation (Fomison 1963; Foster, 2006). Additionally "pea-gravel" sized greywacke pebbles were found dispersed throughout sections of the South Bay shore platforms, though they were attributesd to slopewash (Duckmanton, 1974) this is less likely since the nearby hills are limestone. A geological investigation along the Kaikoura Coast, at

  11. Hazard analysis in active landslide areas in the State of Veracruz, Mexico

    NASA Astrophysics Data System (ADS)

    Wilde, Martina; Morales Barrera, Wendy V.; Rodriguez Elizarrarás, Sergio R.; Solleiro Rebolledo, Elizabeth; Sedov, Sergey; Terhorst, Birgit

    2016-04-01

    mass movements are analyzed in order to reconstruct complex interrelations of the causes and effects of landslide events. One of the major objectives of this research is to evaluate the potential hazard of active landslide areas. Detailed field analyzes were performed to investigate the situations and dynamics of the slope movements. Therefore, geomorphological mapping, sediment characterization as well as geophysical methods are applied. On the one hand, a detailed sediment characterization aims to identify the type of material (e.g. geotechnical attributes), on the other sediments can provide information on different activity phases, respectively movement processes in slide masses. Furthermore, the focus is placed on the determination of landslide relevant parameters and thresholds. Digital elevation models, which were generated before the onset of slope movements, are integrated in the geomorphological analysis. The poster presents the specific study sites in Veracruz and the situation of endangered slopes before and after the landslide events. It is planned to use this knowledge to model susceptibility maps for the region in the future. Moreover, field data will be used as basic information for further monitoring plans. Resulting susceptibility maps will be provided to the responsible authorities in order to support sustainable planning of settlements and infrastructure in hazardous regions.

  12. 40 CFR 265.201 - Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Special requirements for generators of... Systems § 265.201 Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous waste in tanks. (a) The requirements of this section apply to small quantity generators of...

  13. 40 CFR 265.201 - Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Special requirements for generators of... Systems § 265.201 Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous waste in tanks. (a) The requirements of this section apply to small quantity generators of...

  14. 40 CFR 265.201 - Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Special requirements for generators of... Systems § 265.201 Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous waste in tanks. (a) The requirements of this section apply to small quantity generators of...

  15. Active Ageing: Intergenerational Relationships and Social Generativity.

    PubMed

    Rossi, Giovanna; Boccacin, Lucia; Bramanti, Donatella; Meda, Stefania G

    2014-01-01

    This contribution is a reflection on the concept of active ageing from the perspective of relational sociology. At the same time, it offers practical implications and outlines possible future courses of action, in the face of demographic and relational scenarios rapidly changing, and the challenges that each day people of all generations are called to cope with. Active ageing is quite a recent concept and indicates an attitude towards ageing that enhances the quality of life as people become older. The goal of active ageing is to enable people to realise their potential for physical, social and mental well-being and to participate in social life also in the last stage of the life cycle. In this phase, the presence of a network of support, security and care adequate to the possible onset of problems and criticalities is crucial. Relational sociology frames the phenomenon of an ageing population in a dense network of social relations, primarily at the level of family and community. For this reason, as supported by the most recent sociological literature and evidence from studies conducted in Italy and abroad (cf. SHARE), it is extremely important to investigate the link between active ageing, intergenerational orientation (solidarity and exchanges) and practices of prosociality (i.e. engagement in third-sector activities and volunteering in later life).

  16. Cytoplasmic Drosha activity generated by alternative splicing

    PubMed Central

    Dai, Lisheng; Chen, Kevin; Youngren, Brenda; Kulina, Julia; Yang, Acong; Guo, Zhengyu; Li, Jin; Yu, Peng; Gu, Shuo

    2016-01-01

    RNase III enzyme Drosha interacts with DGCR8 to form the Microprocessor, initiating canonical microRNA (miRNA) maturation in the nucleus. Here, we re-evaluated where Drosha functions in cells using Drosha and/or DGCR8 knock out (KO) cells and cleavage reporters. Interestingly, a truncated Drosha mutant located exclusively in the cytoplasm cleaved pri-miRNA effectively in a DGCR8-dependent manner. In addition, we demonstrated that in vitro generated pri-miRNAs when transfected into cells could be processed to mature miRNAs in the cytoplasm. These results indicate the existence of cytoplasmic Drosha (c-Drosha) activity. Although a subset of endogenous pri-miRNAs become enriched in the cytoplasm of Drosha KO cells, it remains unclear whether pri-miRNA processing is the main function of c-Drosha. We identified two novel in-frame Drosha isoforms generated by alternative splicing in both HEK293T and HeLa cells. One isoform loses the putative nuclear localization signal, generating c-Drosha. Further analysis indicated that the c-Drosha isoform is abundant in multiple cell lines, dramatically variable among different human tissues and upregulated in multiple tumors, suggesting that c-Drosha plays a unique role in gene regulation. Our results reveal a new layer of regulation on the miRNA pathway and provide novel insights into the ever-evolving functions of Drosha. PMID:27471035

  17. Guidelines for generators to meet HWHF acceptance requirements for hazardous, radioactive, and mixed wastes at Berkeley Lab. Revision 3

    SciTech Connect

    Albert, R.

    1996-06-01

    This document provides performance standards that one, as a generator of hazardous chemical, radioactive, or mixed wastes at the Berkeley Lab, must meet to manage their waste to protect Berkeley Lab staff and the environment, comply with waste regulations and ensure the continued safe operation of the workplace, have the waste transferred to the correct Waste Handling Facility, and enable the Environment, Health and Safety (EH and S) Division to properly pick up, manage, and ultimately send the waste off site for recycling, treatment, or disposal. If one uses and generates any of these wastes, one must establish a Satellite Accumulation Area and follow the guidelines in the appropriate section of this document. Topics include minimization of wastes, characterization of the wastes, containers, segregation, labeling, empty containers, and spill cleanup and reporting.

  18. Gasification characteristics of an activated carbon catalyst during the decomposition of hazardous waste materials in supercritical water

    SciTech Connect

    Matsumura, Yukihiko; Nuessle, F.W.; Antal, M.J. Jr.

    1996-10-01

    Recently, carbonaceous materials were proved to be effective catalysts for hazardous waste decomposition in supercritical water. Gasification of the carbonaceous catalyst itself is also expected, however, under supercritical conditions. Thus, it is essential to determine the gasification rate of the carbonaceous materials during this process to determine the active lifetime of the catalysts. For this purpose, the gasification characteristics of granular coconut shell activated carbon in supercritical water alone (600-650{degrees}C, 25.5-34.5 MPa) were investigated. The gasification rate at subatmospheric pressure agreed well with the gasification rate at supercritical conditions, indicating the same reaction mechanism. Methane generation under these conditions is via pyrolysis, and thus is not affected by the water pressure. An iodine number increase of 25% was observed as a result of the supercritical water gasification.

  19. Next generation hazard detection via ultrafast coherent anti-Stokes Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    Brady, John J.; Pellegrino, Paul M.

    2013-05-01

    Multiplex coherent anti-Stokes Raman spectroscopy (MCARS) is used to detect an explosive precursor material and two chemical warfare simulants. The spectral bandwidth of the femtosecond laser pulse used in these studies is sufficient to coherently and simultaneously drive all the vibrational modes in the molecule of interest. The research performed here demonstrates that MCARS has the capability to detect an explosive precursor (e.g., acetone) and hazardous materials, such as dimethyl methylphosphonate and 2-chloroethyl methyl sulfide (a sarin and a mustard gas chemical warfare simulant, respectively), with high specificity. Evidence shows that MCARS is capable of overcoming common the sensitivity limitations of spontaneous Raman scattering, thus allowing for the detection of the target material in milliseconds with standard USB spectrometers as opposed to seconds with intensified spectrometers. The exponential increase in the number of scattered photons suggests that the MCARS technique may be capable of overcoming range detection challenges common to spontaneous Raman scattering.

  20. 20 CFR 627.225 - Employment generating activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... generating activities, economic development activities, investment in revolving loan funds, capitalization of... activities, economic development activities, or similar activities. (b) JTPA funds may be used for normal... chambers of commerce); JTPA staff participation on economic development boards and commissions, and...

  1. Colony Rheology: Active Arthropods Generate Flows

    NASA Astrophysics Data System (ADS)

    Daniels, Karen; Mann, Michael; Charbonneau, Patrick

    2015-03-01

    Hydrodynamic-like flows are observed in biological systems as varied as bacteria, insects, birds, fish, and mammals. Both the phenomenology (e.g. front instabilities, milling motions) and the interaction types (hydrodynamic, direct contact, psychological, excluded-volume) strongly vary between systems, but a question common to all of them is to understand the role of particle-scale fluctuations in controlling large-scale rheological behaviors. We will address these questions through experiments on a new system, Tyrolichus casei (cheese mites), which live in dense, self-mixing colonies composed of a mixture of living mites and inert flour/detritus. In experiments performed in a Hele-Shaw geometry, we observe that the rheology of a colony is strongly dependent on the relative concentration of active and inactive particles. In addition to spreading flows, we also observe that the system can generate convective circulation and auto-compaction.

  2. T cell activation requires force generation

    PubMed Central

    Hu, Kenneth H.

    2016-01-01

    Triggering of the T cell receptor (TCR) integrates both binding kinetics and mechanical forces. To understand the contribution of the T cell cytoskeleton to these forces, we triggered T cells using a novel application of atomic force microscopy (AFM). We presented antigenic stimulation using the AFM cantilever while simultaneously imaging with optical microscopy and measuring forces on the cantilever. T cells respond forcefully to antigen after calcium flux. All forces and calcium responses were abrogated upon treatment with an F-actin inhibitor. When we emulated the forces of the T cell using the AFM cantilever, even these actin-inhibited T cells became activated. Purely mechanical stimulation was not sufficient; the exogenous forces had to couple through the TCR. These studies suggest a mechanical–chemical feedback loop in which TCR-triggered T cells generate forceful contacts with antigen-presenting cells to improve access to antigen. PMID:27241914

  3. STRUCTURE-ACTIVITY APPROACHES AND DATA EXPLORATION TOOLS FOR PRIORITIZING AND ASSESSING THE TOXICITY OF HAZARDOUS AIR POLLUTANTS

    EPA Science Inventory


    STRUCTURE-ACTIVITY APPROACHES AND DATA EXPLORATION TOOLS FOR PRIORITIZING AND ASSESSING THE TOXICITY OF HAZARDOUS AIR POLLUTANTS

    Hazardous Air Pollutants (HAPs) refers to a set of structurally diverse environmental chemicals, many with limited toxicity data, that have...

  4. 49 CFR 388.7 - Joint administrative activities related to enforcement of safety and hazardous materials laws and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... enforcement of safety and hazardous materials laws and regulations. 388.7 Section 388.7 Transportation Other... administrative activities related to enforcement of safety and hazardous materials laws and regulations. To... nature and extent of the authority and capabilities of the respective agencies to enforce the safety...

  5. 40 CFR 260.40 - Additional regulation of certain hazardous waste recycling activities on a case-by-case basis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Additional regulation of certain hazardous waste recycling activities on a case-by-case basis. 260.40 Section 260.40 Protection of... SYSTEM: GENERAL Rulemaking Petitions § 260.40 Additional regulation of certain hazardous waste...

  6. 40 CFR 260.40 - Additional regulation of certain hazardous waste recycling activities on a case-by-case basis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Additional regulation of certain hazardous waste recycling activities on a case-by-case basis. 260.40 Section 260.40 Protection of... SYSTEM: GENERAL Rulemaking Petitions § 260.40 Additional regulation of certain hazardous waste...

  7. 40 CFR 260.40 - Additional regulation of certain hazardous waste recycling activities on a case-by-case basis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Additional regulation of certain hazardous waste recycling activities on a case-by-case basis. 260.40 Section 260.40 Protection of... SYSTEM: GENERAL Rulemaking Petitions § 260.40 Additional regulation of certain hazardous waste...

  8. 40 CFR 260.40 - Additional regulation of certain hazardous waste recycling activities on a case-by-case basis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Additional regulation of certain hazardous waste recycling activities on a case-by-case basis. 260.40 Section 260.40 Protection of... SYSTEM: GENERAL Rulemaking Petitions § 260.40 Additional regulation of certain hazardous waste...

  9. 40 CFR 260.40 - Additional regulation of certain hazardous waste recycling activities on a case-by-case basis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Additional regulation of certain hazardous waste recycling activities on a case-by-case basis. 260.40 Section 260.40 Protection of... SYSTEM: GENERAL Rulemaking Petitions § 260.40 Additional regulation of certain hazardous waste...

  10. Health hazard evaluation report No. HETA 81-278-1371, Warrick Generating Station, Yankeetown, Indiana

    SciTech Connect

    Zey, J.N.; Donohue, M.

    1983-09-01

    Environmental samples were collected to evaluate employee exposures to airborne concentrations of nitrogen dioxide, nitric oxide, sulfur dioxide, coal dust, fly ash, crystalline silica, and inorganic metals. In addition, gas leaks from the boilers were evaluated. While the majority of personal samples were below current criteria, a health hazard did exist for some employees exposed to sulfur dioxide, coal dust, and crystalline silica. Highest concentrations were obtained on samples worn by electrical and maintenance personnel and employees working on the positive pressure boiler (unit 4). In addition, the potential exists for employee exposure to boiler gases due to boiler leaks. Respiratory symptoms of cough, phlegm production, and wheezing were twice the expected rate for this group of workers. If preventive maintenance and engineering measures are employed, the occurrence of continued group health effects will likely be reduced. Recommendations are made in the body of the full report for an improved respiratory protection program, reducing leaks from boiler units, and for periodic environmental monitoring of the employees.

  11. Sea-ice hazards, associated risks and implications for human activities in the Arctic

    NASA Astrophysics Data System (ADS)

    Eicken, Hajo; Mahoney, Andrew; Jones, Joshua

    2014-05-01

    Polar sea ice serves important functions in the Earth system, including as climate regulator, habitat for diverse biological communities, or substrate and platform for a range of human activities. Subsumed under the concept of sea-ice services, polar ice covers are associated with benefits and risks of harm to ecosystems and people. Recent changes in Arctic ice extent, thickness and mobility have transformed services derived from sea ice. We summarize how these changes have diminished some benefits derived from the ice cover, while increasing others. More important, growing maritime activities in the North and a changing ice cover drive a need for better understanding of sea-ice hazards and the risk they represent in the context of human activities in the Arctic. Three major aspects of this problem are: (1) Broader risks associated with a rapid reduction in summer ice extent, such as geographic shifts in marine ecosystems and warming of submarine permafrost and adjacent land; (2) hazards resulting from changes in sea ice extent and dynamics such as increased coastal erosion and threats to infrastructure; and (3) risks derived from the combination of sea-ice hazards and human activities such as shipping or offshore resource development. Problem (1) is typically seen as a slow-onset hazard that requires a response in the form of mitigation and adaptation. At the same time, the importance of linkages between summer sea-ice reduction to processes outside of the Arctic has only recently emerged (such as atmospheric circulation patterns and extreme weather events) and remains difficult to quantify. Hazards and risks subsumed under (2) and (3) are more localized but with potentially major ecological and socio-economic consequences beyond the Arctic. Drawing on examples from our research in Alaska, we review and illustrate key aspects of sea-ice hazards in terms of risks to ecosystems, people and infrastructure in the coastal zone and Arctic shelf seas. In the Pacific

  12. 75 FR 79304 - Technical Corrections to the Standards Applicable to Generators of Hazardous Waste; Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    .... 262.34(j) and (k)) in order to indicate that eligible academic entities that were Performance Track... Laboratories Owned by Colleges and Universities and Other Eligible Academic Entities Formally Affiliated With... waste generator requirements known as the ``Academic Laboratories rule'' or ``Subpart K'' which...

  13. Industrial Processes to Reduce Generation of Hazardous Waste at DoD Facilities. Phase 2 Report. Evaluation of 18 Case Studies.

    DTIC Science & Technology

    1985-07-15

    AFB 3-34 3-10 Explosive Properties of Dry Organic Media 3-51 3-11 Alternative Painting Technologies 3-71 4-1 Hazardous Waste from Nonspecific Sources 4...which blasting is carried out with "organic" media. Concern was expressed that generation of dust may pose a possible explosion hazard. There are two...during storage, are . difficult to recycle, and rapidly degrade, producing large amounts of dust that can create an explosion hazard. The used media

  14. Management of hazardous wastes Lawrence Livermore National Laboratory

    SciTech Connect

    Jackson, C.S.

    1993-11-01

    Lawrence Livermore National Laboratory (LLNL), during the course of numerous research activities, generates hazardous, radioactive, and mixed (radioactive and hazardous) wastes. The management of these waste materials is highly regulated in the United States (US). This paper focuses on the hazardous waste regulations that limit and prescribe waste management at LLNL.

  15. Identifying the hazard characteristics of powder byproducts generated from semiconductor fabrication processes.

    PubMed

    Choi, Kwang-Min; An, Hee-Chul; Kim, Kwan-Sick

    2015-01-01

    Semiconductor manufacturing processes generate powder particles as byproducts which potentially could affect workers' health. The chemical composition, size, shape, and crystal structure of these powder particles were investigated by scanning electron microscopy equipped with an energy dispersive spectrometer, Fourier transform infrared spectrometry, and X-ray diffractometry. The powders generated in diffusion and chemical mechanical polishing processes were amorphous silica. The particles in the chemical vapor deposition (CVD) and etch processes were TiO(2) and Al(2)O(3), and Al(2)O(3) particles, respectively. As for metallization, WO(3), TiO(2), and Al(2)O(3) particles were generated from equipment used for tungsten and barrier metal (TiN) operations. In photolithography, the size and shape of the powder particles showed 1-10 μm and were of spherical shape. In addition, the powders generated from high-current and medium-current processes for ion implantation included arsenic (As), whereas the high-energy process did not include As. For all samples collected using a personal air sampler during preventive maintenance of process equipment, the mass concentrations of total airborne particles were < 1 μg, which is the detection limit of the microbalance. In addition, the mean mass concentrations of airborne PM10 (particles less than 10 μm in diameter) using direct-reading aerosol monitor by area sampling were between 0.00 and 0.02 μg/m(3). Although the exposure concentration of airborne particles during preventive maintenance is extremely low, it is necessary to make continuous improvements to the process and work environment, because the influence of chronic low-level exposure cannot be excluded.

  16. 78 FR 8699 - Pipeline Safety: Information Collection Activities, Revision to Annual Report for Hazardous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ..., Revision to Annual Report for Hazardous Liquid Pipeline Systems AGENCY: Pipeline and Hazardous Materials...) invites comments on its intention to revise form PHMSA F 7000-1.1--Annual Report for Hazardous Liquid... hazardous liquid operators' annual reports is an important tool for identifying safety trends in...

  17. Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances.

    PubMed

    Matthiessen, Peter; Ankley, Gerald T; Biever, Ronald C; Bjerregaard, Poul; Borgert, Christopher; Brugger, Kristin; Blankinship, Amy; Chambers, Janice; Coady, Katherine K; Constantine, Lisa; Dang, Zhichao; Denslow, Nancy D; Dreier, David A; Dungey, Steve; Gray, L Earl; Gross, Melanie; Guiney, Patrick D; Hecker, Markus; Holbech, Henrik; Iguchi, Taisen; Kadlec, Sarah; Karouna-Renier, Natalie K; Katsiadaki, Ioanna; Kawashima, Yukio; Kloas, Werner; Krueger, Henry; Kumar, Anu; Lagadic, Laurent; Leopold, Annegaaike; Levine, Steven L; Maack, Gerd; Marty, Sue; Meador, James; Mihaich, Ellen; Odum, Jenny; Ortego, Lisa; Parrott, Joanne; Pickford, Daniel; Roberts, Mike; Schaefers, Christoph; Schwarz, Tamar; Solomon, Keith; Verslycke, Tim; Weltje, Lennart; Wheeler, James R; Williams, Mike; Wolf, Jeffrey C; Yamazaki, Kunihiko

    2017-03-01

    A SETAC Pellston Workshop(®) "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrine-disrupting substance (EDS) under review. The workshop additionally considered recent developments in the identification of EDS. Case studies were undertaken on 6 endocrine-active substances (EAS-not necessarily proven EDS, but substances known to interact directly with the endocrine system) that are representative of a range of perturbations of the endocrine system and considered to be data rich in relevant information at multiple biological levels of organization for 1 or more ecologically relevant taxa. The substances selected were 17α-ethinylestradiol, perchlorate, propiconazole, 17β-trenbolone, tributyltin, and vinclozolin. The 6 case studies were not comprehensive safety evaluations but provided foundations for clarifying key issues and procedures that should be considered when assessing the ecotoxicological hazards and risks of EAS and EDS. The workshop also highlighted areas of scientific uncertainty, and made specific recommendations for research and methods-development to resolve some of the identified issues. The present paper provides broad guidance for scientists in regulatory authorities, industry, and academia on issues likely to arise during the ecotoxicological hazard and risk assessment of EAS and EDS. The primary conclusion of this paper, and of the SETAC Pellston Workshop on which it is based, is that if data on environmental exposure, effects on sensitive species and life-stages, delayed effects, and effects at low concentrations are robust, initiating environmental risk

  18. An update on UNAVCO/COCONet High Frequency Real-Time Products: Towards a next generation multi-hazard network

    NASA Astrophysics Data System (ADS)

    Mencin, D.; Mattioli, G. S.; Feaux, K.; Looney, S.; Sievers, C.; Meertens, C. M.

    2013-05-01

    COCONet is designed to be a near real-time multi-hazard GPS-Met observatory operating across the Caribbean basin. This NSF funded initiative was funded in 2010 by NSF to design, build, and initially maintain a network of 50 new cGPS/Met sites and incorporate another 50 existing sites in the Caribbean region. Data from all COCONet sites flow into the UNAVCO archive and are processed by the PBO analysis centers. The current siting plan calls for 46 new stations, 21 refurbished stations, and 77 existing stations across 26 nations in the Caribbean region. The proposal also called for real-time operation of as many stations as practical. Recent advances in GPS technology and data processing are providing position estimates with centimeter-level precision at high-rate (1-5 Hz) and low latency (<1 s). This along with near real-time met data has generated broad community interest in these data. These data will have the potential to improve our understanding in diverse areas of geophysics including properties of seismic, volcanic, magmatic and tsunami deformation sources, and moreover profoundly transforming rapid event characterization, early warning, as well as hazard mitigation and response. Other scientific and operational applications include tropospheric modeling and better constraints on the dynamics of the Caribbean weather cycle. While design goals are constrained by realities of both the complex logistics of the region and funding, it is hoped the COCONet will serve the diverse and growing needs in the region for the foreseeable future.

  19. Hazardous Waste Permitting

    EPA Pesticide Factsheets

    To provide RCRA hazardous waste permitting regulatory information and resources permitted facilities, hazardous waste generators, and permit writers. To provide the public with information on how they can be involved in the permitting process.

  20. Quaternary Geology and Surface Faulting Hazard: Active and Capable Faults in Central Apennines, Italy

    NASA Astrophysics Data System (ADS)

    Falcucci, E.; Gori, S.

    2015-12-01

    The 2009 L'Aquila earthquake (Mw 6.1), in central Italy, raised the issue of surface faulting hazard in Italy, since large urban areas were affected by surface displacement along the causative structure, the Paganica fault. Since then, guidelines for microzonation were drew up that take into consideration the problem of surface faulting in Italy, and laying the bases for future regulations about related hazard, similarly to other countries (e.g. USA). More specific guidelines on the management of areas affected by active and capable faults (i.e. able to produce surface faulting) are going to be released by National Department of Civil Protection; these would define zonation of areas affected by active and capable faults, with prescriptions for land use planning. As such, the guidelines arise the problem of the time interval and general operational criteria to asses fault capability for the Italian territory. As for the chronology, the review of the international literature and regulatory allowed Galadini et al. (2012) to propose different time intervals depending on the ongoing tectonic regime - compressive or extensional - which encompass the Quaternary. As for the operational criteria, the detailed analysis of the large amount of works dealing with active faulting in Italy shows that investigations exclusively based on surface morphological features (e.g. fault planes exposition) or on indirect investigations (geophysical data), are not sufficient or even unreliable to define the presence of an active and capable fault; instead, more accurate geological information on the Quaternary space-time evolution of the areas affected by such tectonic structures is needed. A test area for which active and capable faults can be first mapped based on such a classical but still effective methodological approach can be the central Apennines. Reference Galadini F., Falcucci E., Galli P., Giaccio B., Gori S., Messina P., Moro M., Saroli M., Scardia G., Sposato A. (2012). Time

  1. The impact of low technology lead hazard reduction activities among children with mildly elevated blood lead levels

    SciTech Connect

    Aschengrau, A.; Hardy, S.; Mackey, P.; Pultinas, D.

    1998-10-01

    This prospective environmental intervention study was conducted to determine the impact of low-technology lead hazard reduction activities among children with mildly elevated blood lead levels. Children whose homes had severe lead hazards were automatically assigned to the intervention group. Children whose homes had lesser hazards were randomly assigned to the intervention group or comparison group. The one-time intervention focused mainly on cleaning and repainting window areas and educating caregivers to maintain effective housekeeping techniques. Changes in blood lead and dust lead loading levels were observed following the interventions. Analysis of covariance was used to adjust comparisons of postintervention levels for preintervention levels and other variables. The lead hazard reduction activities were associated with a modest decline in blood lead levels among children with severe hazards. The magnitude of the decline depended on the confounder that was controlled; the majority ranged from {minus}1.1 to {minus}1.6 {micro}g/dL. A moderate reduction in window well dust lead loading levels was also observed. While low-technology lead hazard reduction measures appeared to be an effective secondary prevention strategy among children with severe household lead hazards, larger studies are needed to confirm these results.

  2. Using ground-level cosmic ray observations for automatically generating predictions of hazardous energetic particle levels

    NASA Astrophysics Data System (ADS)

    Dorman, Lev; Pustil'Nik, Lev; Sternlieb, Abraham; Zukerman, Igor

    It is well known that in periods of great flare energetic particle (FEP) ground events, fluxes of energetic particles can be so big that memory of computers and other electronics in space may be damaged, and satellite and spacecraft operations can be seriously degraded. In these periods it is necessary to switch off some part of electronics for a few hours to protect computer memories. The problem is how to forecast exactly these dangerous phenomena. We show that exact forecasts can be made by using high-energy particles (few GeV/nucleon and higher) whose transportation from the Sun is characterized by much bigger diffusion coefficients than lower energy particles. High-energy particles arrive from the Sun much earlier (8-20 minutes after acceleration and escaping into solar wind) than the lower energy particles that damage electronics (about 30-60 minutes later). We describe here the principles and operation of automated programs ``FEP-Search-1 min'', ``FEP-Search-2 min'',and ``FEPSearch-5 min'', developed and checked in the Emilio Segre' Observatory (ESO) of the Israel Cosmic Ray Center (2025 m above sea level, Rc =10.8 GV). The determination of increasing flux is made by comparison with the intensity, averaged from 120 to 61 minutes, prior to the current one-minute data. For each minute of data the program ``FEP-Search-1 min'' is run. If the result is negative (no simultaneous increase in both channels of total intensity >= 2.5 σ1, where σ1 is the standard deviation for one minute of observation in one channel [for ESO σ1=1.4 %), start the program ``FEP-Search-2 min'', using two minute averages with σ2 = σ1 /√2, and so on. If any positive result is obtained, the ``FEP-Search'' programs check the next minute of data. If the result is again positive, automatically run the on-line the programs ``FEP-Collect'' and ``FEP-Research'' that determine the expected flux and spectrum and generate automatic alerts. These programs are described in Dorman and Zukerman

  3. Estimating evaporative vapor generation from automobiles based on parking activities.

    PubMed

    Dong, Xinyi; Tschantz, Michael; Fu, Joshua S

    2015-07-01

    A new approach is proposed to quantify the evaporative vapor generation based on real parking activity data. As compared to the existing methods, two improvements are applied in this new approach to reduce the uncertainties: First, evaporative vapor generation from diurnal parking events is usually calculated based on estimated average parking duration for the whole fleet, while in this study, vapor generation rate is calculated based on parking activities distribution. Second, rather than using the daily temperature gradient, this study uses hourly temperature observations to derive the hourly incremental vapor generation rates. The parking distribution and hourly incremental vapor generation rates are then adopted with Wade-Reddy's equation to estimate the weighted average evaporative generation. We find that hourly incremental rates can better describe the temporal variations of vapor generation, and the weighted vapor generation rate is 5-8% less than calculation without considering parking activity.

  4. 78 FR 41829 - Pipeline Safety: Information Collection Activities, Revision to Annual Report for Hazardous...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ..., Revision to Annual Report for Hazardous Liquid Pipeline Systems AGENCY: Pipeline and Hazardous Materials... from hazardous liquid operators' annual reports is an important tool for identifying safety trends in... provided for each information collection: (1) Abstract for the affected annual report form; (2) title...

  5. 77 FR 68130 - Agency Information Collection Activities; Proposed Collection; Comment Request; Voluntary Hazard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... Collection; Comment Request; Voluntary Hazard Analysis and Critical Control Point Manuals for Operators and... promote the application of Hazard Analysis and Critical Control Point (HACCP) principles to reduce the... of information technology. Voluntary Hazard Analysis and Critical Control Point Manuals for...

  6. 75 FR 40839 - Agency Information Collection Activities; Proposed Collection; Comment Request; Hazard Analysis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... Collection; Comment Request; Hazard Analysis and Critical Control Point Procedures for the Safe and Sanitary... requirements for applying hazard analysis and critical control point (HAACP) procedures for safe and sanitary... appropriate, and other forms of information technology. Hazard Analysis and Critical Control Point...

  7. Fluidic Active Transducer for Electricity Generation

    PubMed Central

    Yang, YoungJun; Park, Junwoo; Kwon, Soon-Hyung; Kim, Youn Sang

    2015-01-01

    Flows in small size channels have been studied for a long time over multidisciplinary field such as chemistry, biology and medical through the various topics. Recently, the attempts of electricity generation from the small flows as a new area for energy harvesting in microfluidics have been reported. Here, we propose for the first time a new fluidic electricity generator (FEG) by modulating the electric double layer (EDL) with two phase flows of water and air without external power sources. We find that an electric current flowed by the forming/deforming of the EDL with a simple separated phase flow of water and air at the surface of the FEG. Electric signals between two electrodes of the FEG are checked from various water/air passing conditions. Moreover, we verify the possibility of a self-powered air slug sensor by applying the FEG in the detection of an air slug. PMID:26511626

  8. Fluidic Active Transducer for Electricity Generation.

    PubMed

    Yang, YoungJun; Park, Junwoo; Kwon, Soon-Hyung; Kim, Youn Sang

    2015-10-29

    Flows in small size channels have been studied for a long time over multidisciplinary field such as chemistry, biology and medical through the various topics. Recently, the attempts of electricity generation from the small flows as a new area for energy harvesting in microfluidics have been reported. Here, we propose for the first time a new fluidic electricity generator (FEG) by modulating the electric double layer (EDL) with two phase flows of water and air without external power sources. We find that an electric current flowed by the forming/deforming of the EDL with a simple separated phase flow of water and air at the surface of the FEG. Electric signals between two electrodes of the FEG are checked from various water/air passing conditions. Moreover, we verify the possibility of a self-powered air slug sensor by applying the FEG in the detection of an air slug.

  9. Hazard analysis of active tectonics through geomorphometric parameters to cultural heritage conservation: the case of Paphos in Cyprus

    NASA Astrophysics Data System (ADS)

    Argyriou, A. V.; Sarris, A.; Alexakis, D.; Agapiou, A.; Themistocleous, K.; Lysandrou, V.; Hadjimitsis, D.

    2014-08-01

    Natural hazards, such as earthquakes, can have a large destructive effect on cultural heritage sites conservation. This study aims to assess from a geospatial perspective the risk from natural hazards for the archaeological sites and monuments and evaluate the potential tectonic activity impact on the cultural and historic heritage. Geomorphometric data derivatives that can be extracted from Digital Elevation Models (DEMs) provide information relevant with active tectonics. The specific extracted tectonic information when being used on the basis of analytical hierarchy process and weighted linear combination approach can offer an important robust approach. The ranking of the derived information relatively to specific criteria of weights can enhance the interrelationships and assemblages over neotectonics aspects. The outcomes of that methodological framework can propose an assessment approach for the spatial distribution of neotectonic activity and can become a useful tool to assessing seismic hazard for disaster risk reduction. The risk assessment aspects of such a hazard are being interlinked with the archaeological sites in order to highlight and examine those that are exposed on ongoing tectonic activity and seismic hazard. Paphos area in Cyprus has been used as the test bed for the particular analysis. The results show an important number of archaeological sites being located within zones of high degree of neotectonic activity.

  10. Analysis of The Xx Century Effusive Activity At Mount Etna To Assess The Potential Effusive Hazard.

    NASA Astrophysics Data System (ADS)

    Andronico, D.; Lodato, L.; Neri, M.

    We examined older documents and publications together with more recent and de- tailed reports related to the 20th century effusive activity (terminal and flank eruptions) at Mt. Etna, with the primary objective of creating a single data-base of volcanologi- cal data, at present lacking in the literature. The restitution in digital form of the maps of the lava fields allowed to measure, with great precision compared with previous estimations, the area and length of every lava flow, allowing improved estimates of volumes and effusive rates. The quantity and the quality of the collected bibliographic information of the studied eruptions improve progressively from the beginning of the century up to the present, and can be considered complete for the flank activity. The data of each single eruption have been inserted into a relational database, that pro- vides both ease of use and the potential of upgrading with information from new or more ancient eruptions. By examining the collected data (e.g. maximum length of lava flows, altitude reached, eruption duration) we obtained some useful relationships, that allowed us to characterise some eruption typologies at Etna. The improvement of the volcanic data related to the effusive activity of the last century represents an impor- tant contribution in terms of volcanic hazard, suggesting for example the areas most at risk by opening of eruptive fractures and lava covering. Statistical observations can be a useful contribution to the planning required by civil defense in a strongly urban- ized area, such as the etnean one; assessment hazard, in particular, should be focused particularly on the southeastern foot of the volcanic belt, in which the volcanic risk in- creases due to the presence of several populated centers that amount to approximately 500.000 people.

  11. 41 CFR 102-75.130 - If hazardous substance activity took place on the property, what specific information must an...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... activity took place on the property, what specific information must an agency include in the title report... the property, what specific information must an agency include in the title report? If hazardous substance activity took place on the property, the reporting agency must include information on the type...

  12. Computer Analysis of Electromagnetic Field Exposure Hazard for Space Station Astronauts during Extravehicular Activity

    NASA Technical Reports Server (NTRS)

    Hwu, Shian U.; Kelley, James S.; Panneton, Robert B.; Arndt, G. Dickey

    1995-01-01

    In order to estimate the RF radiation hazards to astronauts and electronics equipment due to various Space Station transmitters, the electric fields around the various Space Station antennas are computed using the rigorous Computational Electromagnetics (CEM) techniques. The Method of Moments (MoM) was applied to the UHF and S-band low gain antennas. The Aperture Integration (AI) method and the Geometrical Theory of Diffraction (GTD) method were used to compute the electric field intensities for the S- and Ku-band high gain antennas. As a result of this study, The regions in which the electric fields exceed the specified exposure levels for the Extravehicular Mobility Unit (EMU) electronics equipment and Extravehicular Activity (EVA) astronaut are identified for various Space Station transmitters.

  13. A Sinuous Tumulus over an Active Lava Tube at Klauea Volcano: Evolution, Analogs, and Hazard Forecasts

    NASA Technical Reports Server (NTRS)

    Orr, Tim R.; Bleacher, Jacob E.; Patrick, Matthew R.; Wooten, Kelly M.

    2015-01-01

    Inflation of narrow tube-fed basaltic lava flows (tens of meters across), such as those confined by topography, can be focused predominantly along the roof of a lava tube. This can lead to the development of an unusually long tumulus, its shape matching the sinuosity of the underlying lava tube. Such a situation occurred during Klauea Volcanos (Hawaii, USA) ongoing East Rift Zone eruption on a lava tube active from July through November 2010. Short-lived breakouts from the tube buried the flanks of the sinuous, ridge-like tumulus, while the tumulus crest, its surface composed of lava formed very early in the flows emplacement history, remained poised above the surrounding younger flows. At least several of these breakouts resulted in irrecoverable uplift of the tube roof. Confined sections of the prehistoric Carrizozo and McCartys flows (New Mexico, USA) display similar sinuous, ridge-like features with comparable surface age relationships. We contend that these distinct features formed in a fashion equivalent to that of the sinuous tumulus that formed at Kilauea in 2010. Moreover, these sinuous tumuli may be analogs for some sinuous ridges evident in orbital images of the Tharsis volcanic province on Mars. The short-lived breakouts from the sinuous tumulus at Kilauea were caused by surges in discharge through the lava tube, in response to cycles of deflation and inflation (DI events) at Kilauea's summit. The correlation between DI events and subsequent breakouts aided in lava flow forecasting. Breakouts from the sinuous tumulus advanced repeatedly toward the sparsely populated Kalapana Gardens subdivision, destroying two homes and threatening others. Hazard assessments, including flow occurrence and advance forecasts, were relayed regularly to the Hawai?i County Civil Defense to aid their lava flow hazard mitigation efforts while this lava tube was active.

  14. Next Generation Active Buffet Suppression System

    NASA Technical Reports Server (NTRS)

    Galea, Stephen C.; Ryall, Thomas G.; Henderson, Douglas A.; Moses, Robert W.; White, Edward V.; Zimcik, David G.

    2003-01-01

    Buffeting is an aeroelastic phenomenon that is common to high performance aircraft, especially those with twin vertical tails like the F/A-18, at high angles of attack. These loads result in significant random stresses, which may cause fatigue damage leading to restricted capabilities and availability of the aircraft. This paper describes an international collaborative research activity among Australia, Canada and the United States involving the use of active structural control to alleviate the damaging structural response to these loads. The research program is being co-ordinated by the Air Force Research Laboratory (AFRL) and is being conducted under the auspices of The Technical Cooperative Program (TTCP). This truly unique collaborative program has been developed to enable each participating country to contribute resources toward a program that coalesces a broad range of technical knowledge and expertise into a single investigation. This collaborative program is directed toward a full-scale test of an F/A-18 empennage, which is an extension of an earlier initial test. The current program aims at applying advanced directional piezoactuators, the aircraft rudder, switch mode amplifiers and advanced control strategies on a full-scale structure to demonstrate the enhanced performance and capability of the advanced active BLA control system in preparation for a flight test demonstration.

  15. Hazardous Waste Roundup

    ERIC Educational Resources Information Center

    Farenga, Stephen J.; Joyce, Beverly A.; Ness, Daniel

    2004-01-01

    According to the Environmental Protection Agency (EPA), Americans generate approximately 1.6 million tons of hazardous household waste every year. When most people think of hazardous waste, they generally think of materials used in construction, the defense industry, mining, manufacturing, and agriculture. Few people think of hazardous substances…

  16. Active tectonics of the Seattle fault and central Puget sound, Washington - Implications for earthquake hazards

    USGS Publications Warehouse

    Johnson, S.Y.; Dadisman, S.V.; Childs, J. R.; Stanley, W.D.

    1999-01-01

    We use an extensive network of marine high-resolution and conventional industry seismic-reflection data to constrain the location, shallow structure, and displacement rates of the Seattle fault zone and crosscutting high-angle faults in the Puget Lowland of western Washington. Analysis of seismic profiles extending 50 km across the Puget Lowland from Lake Washington to Hood Canal indicates that the west-trending Seattle fault comprises a broad (4-6 km) zone of three or more south-dipping reverse faults. Quaternary sediment has been folded and faulted along all faults in the zone but is clearly most pronounced along fault A, the northernmost fault, which forms the boundary between the Seattle uplift and Seattle basin. Analysis of growth strata deposited across fault A indicate minimum Quaternary slip rates of about 0.6 mm/yr. Slip rates across the entire zone are estimated to be 0.7-1.1 mm/yr. The Seattle fault is cut into two main segments by an active, north-trending, high-angle, strike-slip fault zone with cumulative dextral displacement of about 2.4 km. Faults in this zone truncate and warp reflections in Tertiary and Quaternary strata and locally coincide with bathymetric lineaments. Cumulative slip rates on these faults may exceed 0.2 mm/yr. Assuming no other crosscutting faults, this north-trending fault zone divides the Seattle fault into 30-40-km-long western and eastern segments. Although this geometry could limit the area ruptured in some Seattle fault earthquakes, a large event ca. A.D. 900 appears to have involved both segments. Regional seismic-hazard assessments must (1) incorporate new information on fault length, geometry, and displacement rates on the Seattle fault, and (2) consider the hazard presented by the previously unrecognized, north-trending fault zone.

  17. High-resolution 3D seismic reflection imaging across active faults and its impact on seismic hazard estimation in the Tokyo metropolitan area

    NASA Astrophysics Data System (ADS)

    Ishiyama, Tatsuya; Sato, Hiroshi; Abe, Susumu; Kawasaki, Shinji; Kato, Naoko

    2016-10-01

    We collected and interpreted high-resolution 3D seismic reflection data across a hypothesized fault scarp, along the largest active fault that could generate hazardous earthquakes in the Tokyo metropolitan area. The processed and interpreted 3D seismic cube, linked with nearby borehole stratigraphy, suggests that a monocline that deforms lower Pleistocene units is unconformably overlain by middle Pleistocene conglomerates. Judging from structural patterns and vertical separation on the lower-middle Pleistocene units and the ground surface, the hypothesized scarp was interpreted as a terrace riser rather than as a manifestation of late Pleistocene structural growth resulting from repeated fault activity. Devastating earthquake scenarios had been predicted along the fault in question based on its proximity to the metropolitan area, however our new results lead to a significant decrease in estimated fault length and consequently in the estimated magnitude of future earthquakes associated with reactivation. This suggests a greatly reduced seismic hazard in the Tokyo metropolitan area from earthquakes generated by active intraplate crustal faults.

  18. Specific activity and hazards of granite samples collected from the Eastern Desert of Egypt.

    PubMed

    Arafa, Wafaa

    2004-01-01

    Fifty granitic rock samples were collected from different plutons in the central part of the Eastern Desert of Egypt and were analyzed for specific concentrations of (238)U, (232)Th and (40)K radionuclei. The measurements were carried out using a high performance and stability Nomad Plus spectroscopy system attached to a 1.7 keV (FWHM) HPGe detector. The spectra were analyzed using the direct gamma counting comparison method as well as the traditional absolute efficiency curve method. The highest average value of (238)U concentration (1184 Bq kg(-1)) was observed at EI Misikat region whereas the highest average values of (40)K and (232)Th concentration (2301.8 and 162.5 Bq kg(-1) respectively), were detected at Gabal Homret Waggat area. The radium equivalent activity (Ra(eq)), the absorbed dose rate (D), the external hazard index (H(ex)) and the annual gonadal dose equivalent were also calculated and compared to the international recommended values. Radon exhalation rate from the rock samples were measured using the activated charcoal canister method. The average value of radon exhalation varies from 0.052 to 0.69 Bq m(-2) h(-1) and depends on the specific concentration of uranium.

  19. 78 FR 69689 - Agency Information Collection Activities; Proposed Collection; Comment Request; Hazard Analysis...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Collection; Comment Request; Hazard Analysis and Critical Control Point Procedures for the Safe and Sanitary... appropriate, and other forms of information technology. Hazard Analysis and Critical Control Point (HACCP... monitoring of the critical control points and other measurements as prescribed in the HACCP plan......

  20. Marine and land active-source seismic investigation of geothermal potential, tectonic structure, and earthquake hazards in Pyramid Lake, Nevada

    SciTech Connect

    Eisses, A.; Kell, A.; Kent, G.; Driscoll, N.; Karlin, R.; Baskin, R.; Louie, J.; Pullammanappallil, S.

    2016-08-01

    Amy Eisses, Annie M. Kell, Graham Kent, Neal W. Driscoll, Robert E. Karlin, Robert L. Baskin, John N. Louie, Kenneth D. Smith, Sathish Pullammanappallil, 2011, Marine and land active-source seismic investigation of geothermal potential, tectonic structure, and earthquake hazards in Pyramid Lake, Nevada: presented at American Geophysical Union Fall Meeting, San Francisco, Dec. 5-9, abstract NS14A-08.

  1. March 2016 Memo: Planning for Removal and Remedial Activities at Hardrock Mining and Mineral Processing Sites with Fluid Hazards

    EPA Pesticide Factsheets

    Memo from EPA Assistant Administrator Mathy Stanislaus, regarding planning for removal and remedial activities at hardrock mining and mineral processing sites with fluid hazards, and to share the Agency’s expectations for the work that is done at these sit

  2. Achromobactor denitrificans SP1 produces pharmaceutically active 25C prodigiosin upon utilizing hazardous di(2-ethylhexyl)phthalate

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Achromobacter denitrificans SP1 isolated from soil sludge heavily contaminated with plastic waste produced a novel pharmaceutically-active 25C prodigiosin analog during growth in a simple mineral salt medium supplemented with hazardous di(2-ethylhexyl)phthalate (DEHP) blended PVC plastics (in situ) ...

  3. NASA/NREN: Next Generation Internet (NGI) Activities

    NASA Technical Reports Server (NTRS)

    desJardins, Richard; Freeman, Ken

    1998-01-01

    Various issues associated with next generation internet (NGI) and the NREN (NASA Research and Education Network) activities are presented in viewgraph form. Specific topics include: 1) NREN architecture; 2) NREN applications; and 3) NREN applied research.

  4. Modelling Active Faults in Probabilistic Seismic Hazard Analysis (PSHA) with OpenQuake: Definition, Design and Experience

    NASA Astrophysics Data System (ADS)

    Weatherill, Graeme; Garcia, Julio; Poggi, Valerio; Chen, Yen-Shin; Pagani, Marco

    2016-04-01

    The Global Earthquake Model (GEM) has, since its inception in 2009, made many contributions to the practice of seismic hazard modeling in different regions of the globe. The OpenQuake-engine (hereafter referred to simply as OpenQuake), GEM's open-source software for calculation of earthquake hazard and risk, has found application in many countries, spanning a diversity of tectonic environments. GEM itself has produced a database of national and regional seismic hazard models, harmonizing into OpenQuake's own definition the varied seismogenic sources found therein. The characterization of active faults in probabilistic seismic hazard analysis (PSHA) is at the centre of this process, motivating many of the developments in OpenQuake and presenting hazard modellers with the challenge of reconciling seismological, geological and geodetic information for the different regions of the world. Faced with these challenges, and from the experience gained in the process of harmonizing existing models of seismic hazard, four critical issues are addressed. The challenge GEM has faced in the development of software is how to define a representation of an active fault (both in terms of geometry and earthquake behaviour) that is sufficiently flexible to adapt to different tectonic conditions and levels of data completeness. By exploring the different fault typologies supported by OpenQuake we illustrate how seismic hazard calculations can, and do, take into account complexities such as geometrical irregularity of faults in the prediction of ground motion, highlighting some of the potential pitfalls and inconsistencies that can arise. This exploration leads to the second main challenge in active fault modeling, what elements of the fault source model impact most upon the hazard at a site, and when does this matter? Through a series of sensitivity studies we show how different configurations of fault geometry, and the corresponding characterisation of near-fault phenomena (including

  5. Pulsed neutron generator for use with pulsed neutron activation techniques

    SciTech Connect

    Rochau, G.E.

    1980-01-01

    A high-output, transportable, pulsed neutron generator has been developed by Sandia National Laboratories for use with Pulsed Neutron Activation (PNA) techniques. The PNA neutron generator generates > 10/sup 10/ 14 MeV D-T neutrons in a 1.2 millisecond pulse. Each operation of the unit will produce a nominal total neutron output of 1.2 x 10/sup 10/ neutrons. The generator has been designed to be easily repaired and modified. The unit requires no additional equipment for operation or measurement of output.

  6. Identifying Activity Cliff Generators of PPAR Ligands Using SAS Maps.

    PubMed

    Méndez-Lucio, Oscar; Pérez-Villanueva, Jaime; Castillo, Rafael; Medina-Franco, José L

    2012-12-01

    Structure-activity relationships (SAR) of compound databases play a key role in hit identification and lead optimization. In particular, activity cliffs, defined as a pair of structurally similar molecules that present large changes in potency, provide valuable SAR information. Herein, we introduce the concept of activity cliff generator, defined as a molecular structure that has a high probability to form activity cliffs with molecules tested in the same biological assay. To illustrate this concept, we discuss a case study where Structure-Activity Similarity maps were used to systematically identify and analyze activity cliff generators present in a dataset of 168 compounds tested against three peroxisome-proliferator-activated receptor (PPAR) subtypes. Single-target and dual-target activity cliff generators for PPARα and δ were identified. In addition, docking calculations of compounds that were classified as cliff generators helped to suggest a hot spot in the target protein responsible of activity cliffs and to analyze its implication in ligand-enzyme interaction.

  7. Active Generations: An Intergenerational Approach to Preventing Childhood Obesity

    ERIC Educational Resources Information Center

    Werner, Danilea; Teufel, James; Holtgrave, Peter L.; Brown, Stephen L.

    2012-01-01

    Background: Over the last 3 decades, US obesity rates have increased dramatically as more children and more adults become obese. This study explores an innovative program, Active Generations, an intergenerational nutrition education and activity program implemented in out-of-school environments (after school and summer camps). It utilizes older…

  8. Disposal of hazardous materials from TxDOT activities. Final report, September 1992-August 1994

    SciTech Connect

    Stallard, M.; Corapcioglu, M.Y.; Beavers, T.; Beck, B.; Mehevec, A.

    1994-11-01

    The process of purchasing, storing, handling and disposal of hazardous waste is demanding. The Texas Department of Transportation deals with many such compounds every day in performing its duty of maintaining over 70,000 miles of Texas roadway. With the new demands being placed on all users of hazardous materials by the new EPA guidelines, procedures must be enacted to ensure TxDOT`s compliance with these ever-changing regulations. The placement of full-time safety and hazardous materials coordinators in each district office will help to ensure that employees follow reporting procedures and use disposal guidelines. The report will discuss these actions and others that might help TxDOT in this task.

  9. Mobile machine hazardous working zone warning system

    SciTech Connect

    Schiffbauer, W.H.; Ganoe, C.W.

    1996-12-31

    A warning system is provided for a mobile working machine to alert an individual of a potentially dangerous condition in the event the individual strays into a hazardous working zone of the machine. The warning system includes a transmitter mounted on the machine and operable to generate a uniform magnetic field projecting beyond an outer periphery of the machine in defining a hazardous working zone around the machine during operation thereof. A receiver, carried by the individual and activated by the magnetic field, provides an alarm signal to alert the individual when he enters the hazardous working zone of the machine.

  10. Mobile machine hazardous working zone warning system

    DOEpatents

    Schiffbauer, William H.; Ganoe, Carl W.

    1999-01-01

    A warning system is provided for a mobile working machine to alert an individual of a potentially dangerous condition in the event the individual strays into a hazardous working zone of the machine. The warning system includes a transmitter mounted on the machine and operable to generate a uniform magnetic field projecting beyond an outer periphery of the machine in defining a hazardous working zone around the machine during operation thereof. A receiver, carried by the individual and activated by the magnetic field, provides an alarm signal to alert the individual when he enters the hazardous working zone of the machine.

  11. Mobile machine hazardous working zone warning system

    DOEpatents

    Schiffbauer, W.H.; Ganoe, C.W.

    1999-08-17

    A warning system is provided for a mobile working machine to alert an individual of a potentially dangerous condition in the event the individual strays into a hazardous working zone of the machine. The warning system includes a transmitter mounted on the machine and operable to generate a uniform magnetic field projecting beyond an outer periphery of the machine in defining a hazardous working zone around the machine during operation. A receiver, carried by the individual and activated by the magnetic field, provides an alarm signal to alert the individual when he enters the hazardous working zone of the machine. 3 figs.

  12. Technology transfer in hazardous waste management

    SciTech Connect

    Drucker, H.

    1989-01-01

    Hazardous waste is a growing problem in all parts of the world. Industrialized countries have had to deal with the treatment and disposal of hazardous wastes for many years. The newly industrializing countries of the world are now faced with immediate problems of waste handling. The developing nations of the world are looking at increasing quantities of hazardous waste generation as they move toward higher levels of industrialization. Available data are included on hazardous waste generation in Asia and the Pacific as a function of Gross Domestic Product (GDP). Although there are many inconsistencies in the data (inconsistent hazardous waste definitions, inconsistent reporting of wastes, etc.) there is definite indication that a growing economy tends to lead toward larger quantities of hazardous waste generation. In developing countries the industrial sector is growing at a faster rate than in the industrialized countries. In 1965 industry accounted for 29% of GDP in the developing countries of the world. In 1987 this had grown to 37% of GDP. In contrast, industry accounted for 40% of GDP in 1965 in industrialized countries and dropped to 35% in 1987. This growth in industrial activity in the developing countries brings an increase in the need to handle hazardous wastes. Although hazardous wastes are ubiquitous, the control of hazardous wastes varies. The number of regulatory options used by various countries in Asia and the Pacific to control wastes are included. It is evident that the industrialized countries, with a longer history of having to deal with hazardous wastes, have found the need to use more mechanisms to control them. 2 refs., 2 figs.

  13. The exposure of Sydney (Australia) to earthquake-generated tsunamis, storms and sea level rise: a probabilistic multi-hazard approach

    PubMed Central

    Dall'Osso, F.; Dominey-Howes, D.; Moore, C.; Summerhayes, S.; Withycombe, G.

    2014-01-01

    Approximately 85% of Australia's population live along the coastal fringe, an area with high exposure to extreme inundations such as tsunamis. However, to date, no Probabilistic Tsunami Hazard Assessments (PTHA) that include inundation have been published for Australia. This limits the development of appropriate risk reduction measures by decision and policy makers. We describe our PTHA undertaken for the Sydney metropolitan area. Using the NOAA NCTR model MOST (Method for Splitting Tsunamis), we simulate 36 earthquake-generated tsunamis with annual probabilities of 1:100, 1:1,000 and 1:10,000, occurring under present and future predicted sea level conditions. For each tsunami scenario we generate a high-resolution inundation map of the maximum water level and flow velocity, and we calculate the exposure of buildings and critical infrastructure. Results indicate that exposure to earthquake-generated tsunamis is relatively low for present events, but increases significantly with higher sea level conditions. The probabilistic approach allowed us to undertake a comparison with an existing storm surge hazard assessment. Interestingly, the exposure to all the simulated tsunamis is significantly lower than that for the 1:100 storm surge scenarios, under the same initial sea level conditions. The results have significant implications for multi-risk and emergency management in Sydney. PMID:25492514

  14. The exposure of Sydney (Australia) to earthquake-generated tsunamis, storms and sea level rise: a probabilistic multi-hazard approach.

    PubMed

    Dall'Osso, F; Dominey-Howes, D; Moore, C; Summerhayes, S; Withycombe, G

    2014-12-10

    Approximately 85% of Australia's population live along the coastal fringe, an area with high exposure to extreme inundations such as tsunamis. However, to date, no Probabilistic Tsunami Hazard Assessments (PTHA) that include inundation have been published for Australia. This limits the development of appropriate risk reduction measures by decision and policy makers. We describe our PTHA undertaken for the Sydney metropolitan area. Using the NOAA NCTR model MOST (Method for Splitting Tsunamis), we simulate 36 earthquake-generated tsunamis with annual probabilities of 1:100, 1:1,000 and 1:10,000, occurring under present and future predicted sea level conditions. For each tsunami scenario we generate a high-resolution inundation map of the maximum water level and flow velocity, and we calculate the exposure of buildings and critical infrastructure. Results indicate that exposure to earthquake-generated tsunamis is relatively low for present events, but increases significantly with higher sea level conditions. The probabilistic approach allowed us to undertake a comparison with an existing storm surge hazard assessment. Interestingly, the exposure to all the simulated tsunamis is significantly lower than that for the 1:100 storm surge scenarios, under the same initial sea level conditions. The results have significant implications for multi-risk and emergency management in Sydney.

  15. Hazardous Waste

    MedlinePlus

    ... you throw these substances away, they become hazardous waste. Some hazardous wastes come from products in our homes. Our garbage can include such hazardous wastes as old batteries, bug spray cans and paint ...

  16. RCRA Part A Permit Application for Waste Management Activities at the Nevada Test Site, Part B Permit Application Hazardous Waste Storage Unit, Nevada Test Site, and Part B Permit Application - Explosives Ordnance Disposal Unit (EODU)

    SciTech Connect

    NSTec Environmental Programs

    2010-06-17

    The Area 5 Hazardous Waste Storage Unit (HWSU) was established to support testing, research, and remediation activities at the Nevada Test Site (NTS), a large-quantity generator of hazardous waste. The HWSU, located adjacent to the Area 5 Radioactive Waste Management Site (RWMS), is a prefabricated, rigid steel-framed, roofed shelter used to store hazardous nonradioactive waste generated on the NTS. No offsite generated wastes are managed at the HWSU. Waste managed at the HWSU includes the following categories: Flammables/Combustibles; Acid Corrosives; Alkali Corrosives; Oxidizers/Reactives; Toxics/Poisons; and Other Regulated Materials (ORMs). A list of the regulated waste codes accepted for storage at the HWSU is provided in Section B.2. Hazardous wastes stored at the HWSU are stored in U.S. Department of Transportation (DOT) compliant containers, compatible with the stored waste. Waste transfer (between containers) is not allowed at the HWSU and containers remain closed at all times. Containers are stored on secondary containment pallets and the unit is inspected monthly. Table 1 provides the metric conversion factors used in this application. Table 2 provides a list of existing permits. Table 3 lists operational Resource Conservation and Recovery Act (RCRA) units at the NTS and their respective regulatory status.

  17. Generator of chemically active low-temperature plasma

    NASA Astrophysics Data System (ADS)

    Tyuftyaev, A. S.; Gadzhiev, M. Kh; Sargsyan, M. A.; Demirov, N. A.; Spector, N. O.

    2016-11-01

    A new generator of high enthalpy (H 0 > 40 kJ/g), chemically active nitrogen and air plasmas was designed and constructed. Main feature of the generator is an expanding channel of an output electrode; the generator belongs to the class of DC plasma torches with thermionic cathode with an efficiency of 80%. The generator ensures the formation of a slightly divergent plasma jet (2α = 12°) with a diameter of D = 10-12 mm, an electric arc maximum power of 20-50 kW, plasma forming gas flow rate 1.0-2.0 g/s, and the average plasma temperature at an outlet of 8000-11000 K.

  18. Relationship between peptide membrane curvature generation and bactericidal activities

    NASA Astrophysics Data System (ADS)

    Schmidt, Nathan; Lee, Michelle; Kuo, David; Ouellette, Andre; Wong, Gerard

    2013-03-01

    Many amphipathic peptides and amphipathic domains in proteins can restructure biological membranes. Two examples are host defense antimicrobial peptides (AMPs) which disrupt and destabilize the cell membranes of microbes, and apolipoproteins which help stabilize nanoscale lipid aggregates. We use complementary x-ray and bacterial cell assays to elucidate the molecular length scale membrane deformations generated by amphipathic peptides with different structural motifs and relate these deformations to their activities on bacteria. Small angle x-ray scattering is used to study the interactions of model membranes with prototypical AMPs and consensus peptides from the amphipathic domains in apolipoproteins. By characterizing the nanoscale curvature deformations induced by these two distinct classes of membrane restructuring peptides we will discuss the role of amino acid composition on curvature generation. Bactericidal assays are used to access the in vivo activities of different amphipathic peptide motifs in order to understand the relationships between cell viability and membrane curvature generation.

  19. Income Generation Activities among Academic Staffs at Malaysian Public Universities

    ERIC Educational Resources Information Center

    Ahmad, Abd Rahman; Soon, Ng Kim; Ting, Ngeoh Pei

    2015-01-01

    Income generation activities have been acquainted among public higher education institutions (HEIs) in Malaysia. Various factors that brought to insufficient of funding caused Higher Education Institutions(HEIs) to seek for additional income as to support the operation expenses. Financial sustainability issues made up the significant impact…

  20. Density of Plutonium Turnings Generated from Machining Activities

    SciTech Connect

    Gonzales, John Robert; Vigil, Duane M.; Jachimowski, Thomas A.; Archuleta, Alonso; Arellano, Gerald Joseph; Melton, Vince Lee

    2016-10-20

    The purpose of this project was to determine the density of plutonium (Pu) turnings generated from the range of machining activities, using both surrogate material and machined Pu turnings. Verify that 500 grams (g) of plutonium will fit in a one quart container using a surrogate equivalent volume and that 100 grams of Pu will fit in a one quart Savy container.

  1. Hazardous Wastes. Two Games for Teaching about the Problem. Environmental Communications Activities. Bulletin 703.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Cooperative Extension Service.

    Two games are presented which demonstrate the complexity of the hazardous waste problem through an introduction to the: (1) economics of waste disposal; (2) legislation surrounding waste disposal; (3) necessity to handle wastes with care; (4) damages to the environmental and human health resulting from improper disposal; (5) correct ways to…

  2. 24 CFR 35.125 - Notice of evaluation and hazard reduction activities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES General Lead-Based Paint Requirements and Definitions for All Programs. § 35.125 Notice of... is undertaken and lead-based paint or lead-based paint hazards are found to be present, or if...

  3. 24 CFR 35.125 - Notice of evaluation and hazard reduction activities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES General Lead-Based Paint Requirements and Definitions for All Programs. § 35.125 Notice of... is undertaken and lead-based paint or lead-based paint hazards are found to be present, or if...

  4. 24 CFR 35.125 - Notice of evaluation and hazard reduction activities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES General Lead-Based Paint Requirements and Definitions for All Programs. § 35.125 Notice of... is undertaken and lead-based paint or lead-based paint hazards are found to be present, or if...

  5. 24 CFR 35.125 - Notice of evaluation and hazard reduction activities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES General Lead-Based Paint Requirements and Definitions for All Programs. § 35.125 Notice of... is undertaken and lead-based paint or lead-based paint hazards are found to be present, or if...

  6. 24 CFR 35.125 - Notice of evaluation and hazard reduction activities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES General Lead-Based Paint Requirements and Definitions for All Programs. § 35.125 Notice of... is undertaken and lead-based paint or lead-based paint hazards are found to be present, or if...

  7. Learn the Basics of Hazardous Waste

    EPA Pesticide Factsheets

    Overview that includes the definition of hazardous waste, EPA’s Cradle-to-Grave Hazardous Waste Management Program, and hazardous waste generation, identification, transportation, recycling, treatment, storage, disposal and regulations.

  8. Special astronomical configurations, solar activity and deep degassing as a trigger of natural hazards

    NASA Astrophysics Data System (ADS)

    Natyaganov, Vladimir; Syvorotkin, Vladimir; Fedorov, Valeriy; Shopin, Sergey

    2016-04-01

    Extraordinary cases of tectonic events (strong earthquakes, volcano eruptions), mine explosions, typhoons, hurricanes, tornado outbreak sequences, ball lightnings, transient luminous events are analyzed in relation with special astronomical configurations, which are specific relative positions of the Sun, Earth, Moon and the closest planets of the Solar System (Venus, Mars and Jupiter) [1]. Usage of special astronomical coordinate systems give evidence not only of correlations but also of hidden causes-and-effect relations between the analyzed phenomena. The geocentric ecliptic latitude system is an example of such astronomical coordinate systems. It gives clear evidence of coherence between strong earthquakes and the maximal Moon declination from the plane of the ecliptic. Extraordinary cases of planet activity from the beginning of XX century till the present time are shown in the years of special astronomical configurations and abrupt increasing of solar activity. According to the empirical scheme of short-term earthquake prediction [3], geomagnetic disturbances are the triggers of earthquakes. Geomagnetic disturbances perform electromagnetic pumping (electromagnetic excitation) of the Earth's interior in the regions of intersections of seismomagnetic meridians with the plate boundaries as a result of electrothermal breakdowns in the heterogeneous medium of tectonic faults. This results in the local intensification of deep degassing [4], decreasing of shear strength of the medium that triggers earthquakes usually after 2 or 3 weeks (±2 days) after the geomagnetic disturbance. Examples of officially registered predictions of Kamchatka earthquakes with M7+ without missing events, including deep-focus earthquakes in the Okhotsk Sea since the year of 2002, are shown. It is discussed correlations and possible cause-and-effect relations between a different phenomena such as - dangerous natural hazardous events such as the record tornado outbreak sequences in the USA

  9. Hazardous Waste Manifest System

    EPA Pesticide Factsheets

    EPA’s hazardous waste manifest system is designed to track hazardous waste from the time it leaves the generator facility where it was produced, until it reaches the off-site waste management facility that will store, treat, or dispose of the waste.

  10. Social studies of volcanology: knowledge generation and expert advice on active volcanoes

    NASA Astrophysics Data System (ADS)

    Donovan, Amy; Oppenheimer, Clive; Bravo, Michael

    2012-04-01

    This paper examines the philosophy and evolution of volcanological science in recent years, particularly in relation to the growth of volcanic hazard and risk science. It uses the lens of Science and Technology Studies to examine the ways in which knowledge generation is controlled and directed by social forces, particularly during eruptions, which constitute landmarks in the development of new technologies and models. It also presents data from a survey of volcanologists carried out during late 2008 and early 2009. These data concern the felt purpose of the science according to the volcanologists who participated and their impressions of the most important eruptions in historical time. It demonstrates that volcanologists are motivated both by the academic science environment and by a social concern for managing the impact of volcanic hazards on populations. Also discussed are the eruptions that have most influenced the discipline and the role of scientists in policymaking on active volcanoes. Expertise in volcanology can become the primary driver of public policy very suddenly when a volcano erupts, placing immense pressure on volcanologists. In response, the epistemological foundations of volcanology are on the move, with an increasing volume of research into risk assessment and management. This requires new, integrated methodologies for knowledge collection that transcend scientific disciplinary boundaries.

  11. Entanglement generation between unstable optically active qubits without photodetectors

    SciTech Connect

    Matsuzaki, Yuichiro; Solinas, Paolo

    2011-09-15

    We propose a robust deterministic scheme to generate entanglement at high fidelity without the need for photodetectors even for quantum bits (qubits) with extremely poor optically active states. Our protocol employs stimulated Raman adiabatic passage for population transfer without actually exciting the system. Furthermore, it is found to be effective even if the environmental decoherence rate is of the same order of magnitude as the atom-photon coupling frequency. Our scheme has the potential to solve entanglement generation problems, e.g., in distributed quantum computing.

  12. Relationship between short activated partial thromboplastin times, thrombin generation, procoagulant factors and procoagulant phospholipid activity.

    PubMed

    Mina, Ashraf; Favaloro, Emmanuel J; Koutts, Jerry

    2012-04-01

    Short activated partial thromboplastin times (APTTs) are associated with thrombosis. However, what short APTTs actually represent in terms of possible mechanistic pathways is not well characterized. We have assessed thrombin generation as compared with levels of procoagulant factor (fibrinogen, V, VIII, IX, XI and XII) activities, von Willebrand factor level and activity using collagen binding, as well as procoagulant phospholipid activity, in 113 consecutive samples exhibiting a short APTT compared with an equal number of age-matched and sex-matched samples yielding a normal APTT. We found a significant difference in peak thrombin generation, velocity index and area under the curve between the two groups, and that thrombin generation markers correlated with the APTT, procoagulant phospholipid activity and several procoagulant clotting factors. We conclude that short APTTs represent a procoagulant milieu, as represented by heightened thrombin generation and several other heightened procoagulant activities, which may help explain the association with thrombosis.

  13. Occupational Safety and Health Guidance Manual for Hazardous Waste Site Activities

    DTIC Science & Technology

    1985-10-01

    environment and the cleanup of inactive waste disposal sites." This manual is a guidance document for managers responsible for occupational safety and health...programs at inactive hazardous waste sites. It assumes a basic knowledge of science and experience in occupational safety and health. It is the...product of a four-agency committee (the National Institute for Occupational Safety and Health NIOSH, the Occupational Safety and Health Administration OSHA

  14. A mobile laboratory for surface and subsurface imaging in geo-hazard monitoring activity

    NASA Astrophysics Data System (ADS)

    Cornacchia, Carmela; Bavusi, Massimo; Loperte, Antonio; Pergola, Nicola; Pignatti, Stefano; Ponzo, Felice; Lapenna, Vincenzo

    2010-05-01

    A new research infrastructure for supporting ground-based remote sensing observations in the different phases of georisk management cycle is presented. This instrumental facility has been designed and realised by TeRN, a public-private consortium on Earth Observations and Natural Risks, in the frame of the project "ImpresAmbiente" funded by Italian Ministry of Research and University. The new infrastructure is equipped with ground-based sensors (hyperspectral cameras, thermal cameras, laser scanning and electromagnetic antennae) able to remotely map physical parameters and/or earth-surface properties (temperature, soil moisture, land cover, etc…) and to illuminate near-surface geological structures (fault, groundwater tables, landslide bodies etc...). Furthermore, the system can be used for non-invasive investigations of architectonic buildings and civil infrastructures (bridges, tunnel, road pavements, etc...) interested by natural and man-made hazards. The hyperspectral cameras can acquire high resolution images of earth-surface and cultural objects. They are operating in the Visible Near InfraRed (0.4÷1.0μm) with 1600 spatial pixel and 3.7nm of spectral sampling and in the Short Wave InfraRed (1.3÷2.5µm) spectral region with 320 spatial pixel and 5nm of spectral sampling. The IR cameras are operating in the Medium Wavelength InfraRed (3÷5µm; 640x512; NETD< 20 mK) and in the Very Long Wavelength InfraRed region (7.7÷11.5 µm; 320x256; NETD<25 mK) with a frame rate higher than 100Hz and are both equipped with a set of optical filters in order to operate in multi-spectral configuration. The technological innovation of ground-based laser scanning equipment has led to an increased resolution performances of surveys with applications in several field, as geology, architecture, environmental monitoring and cultural heritage. As a consequence, laser data can be useful integrated with traditional monitoring techniques. The Laser Scanner is characterized by very

  15. Income-generating activities for family planning acceptors.

    PubMed

    1989-07-01

    The Income Generating Activities program for Family Planning Acceptors was introduced in Indonesia in 1979. Capital input by the Indonesian National Family Planning Coordination Board and the UN Fund for Population Activities was used to set up small businesses by family planning acceptors. In 2 years, when the businesses become self-sufficient, the loans are repaid, and the money is used to set up new family planning acceptors in business. The program strengthens family planning acceptance, improves the status of women, and enhances community self-reliance. The increase in household income generated by the program raises the standards of child nutrition, encourages reliance on the survival of children, and decreases the value of large families. Approximately 18,000 Family Planning-Income Generating Activities groups are now functioning all over Indonesia, with financial assistance from the central and local governments, the World Bank, the US Agency for International Development, the UN Population Fund, the Government of the Netherlands, and the Government of Australia through the Association of South East Asian Nations.

  16. Enhanced ionospheric plasma bubble generation in more active ITCZ

    NASA Astrophysics Data System (ADS)

    Li, Guozhu; Otsuka, Yuichi; Ning, Baiqi; Abdu, M. A.; Yamamoto, M.; Wan, Weixing; Liu, Libo; Abadi, Prayitno

    2016-03-01

    A close link between the atmospheric Intertropical Convergence Zone (ITCZ) and ionospheric plasma bubble has been proposed since the last century. But this relationship has often appeared to be less than convincing due to the simultaneous roles played by several other factors in shaping the global distribution of ionospheric bubbles. From simultaneous collaborative radar multibeam steering measurements at Kototabang (0.2°S, 100.3°E) and Sanya (18.4°N, 109.6°E), conducted during September-October of 2012 and 2013, we find that the total numbers of nights with bubble (i.e., occurrence rates) at the two closely located longitudes (Kototabang and Sanya) are comparable. But interestingly, the total number of nights with locally generated bubble (i.e., generation rate) over Kototabang is clearly more than that over Sanya. Further analysis reveals that a more active ITCZ is situated around the longitude of Kototabang. We surmise that the enhanced ionospheric bubble generation at Kototabang longitude could be caused by a higher gravity wave activity associated with the more active ITCZ.

  17. Active tectonics in Eastern Lunana (NW Bhutan): Implications for the seismic and glacial hazard potential of the Bhutan Himalaya

    NASA Astrophysics Data System (ADS)

    Meyer, M. C.; Wiesmayr, G.; Brauner, M.; HäUsler, H.; Wangda, D.

    2006-06-01

    Paleoseismological investigations, brittle fault analysis, and paleostrain calculations combined with the interpretation of satellite imagery and flood wave modeling were used to investigate the seismic and associated glacial hazard potential in Eastern Lunana, a remote area in NW Bhutan. Seismically induced liquefaction features, cracked pebbles, and a surface rupture of about 6.8 km length constrain the occurrence of M ≥ 6 earthquakes within this high-altitude periglacial environment, which are the strongest earthquakes ever been reported for the Kingdom of Bhutan. Seismicity occurs along conjugate sets of faults trending NE-SW to NNW-SSE by strike-slip and normal faulting mechanism indicating E-W extension and N-S shortening. The strain field for these conjugate sets of active faults is consistent with widespread observations of young E-W expansion throughout southern Tibet and the north Himalaya. We expect, however, that N-S trending active strike-slip faults may even reach much farther to the south, at least into southern Bhutan. Numerous glacial lakes exist in the investigation area, and today more than 100 × 106 m3 of water are stored in moraine-dammed and supraglacial lakes which are crosscut by active faults. Strong earthquakes may trigger glacial lake outburst floods, and the impact of such flash floods may be worst 80 km downstream where the valley is broad and densely populated. Consequently, tectonic models of active deformation have to be closely linked with glacial hazard evaluation and require rethinking and modification.

  18. Sustainable System for Residual Hazards Management

    SciTech Connect

    Kevin M. Kostelnik; James H. Clarke; Jerry L. Harbour

    2004-06-01

    Hazardous, radioactive and other toxic substances have routinely been generated and subsequently disposed of in the shallow subsurface throughout the world. Many of today’s waste management techniques do not eliminate the problem, but rather only concentrate or contain the hazardous contaminants. Residual hazards result from the presence of hazardous and/or contaminated material that remains on-site following active operations or the completion of remedial actions. Residual hazards pose continued risk to humans and the environment and represent a significant and chronic problem that require continuous longterm management (i.e. >1000 years). To protect human health and safeguard the natural environment, a sustainable system is required for the proper management of residual hazards. A sustainable system for the management of residual hazards will require the integration of engineered, institutional and land-use controls to isolate residual contaminants and thus minimize the associated hazards. Engineered controls are physical modifications to the natural setting and ecosystem, including the site, facility, and/or the residual materials themselves, in order to reduce or eliminate the potential for exposure to contaminants of concern (COCs). Institutional controls are processes, instruments, and mechanisms designed to influence human behavior and activity. System failure can involve hazardous material escaping from the confinement because of system degradation (i.e., chronic or acute degradation) or by externalintrusion of the biosphere into the contaminated material because of the loss of institutional control. An ongoing analysis of contemporary and historic sites suggests that the significance of the loss of institutional controls is a critical pathway because decisions made during the operations/remedial action phase, as well as decisions made throughout the residual hazards management period, are key to the longterm success of the prescribed system. In fact

  19. A pilot GIS database of active faults of Mt. Etna (Sicily): A tool for integrated hazard evaluation

    NASA Astrophysics Data System (ADS)

    Barreca, Giovanni; Bonforte, Alessandro; Neri, Marco

    2013-02-01

    A pilot GIS-based system has been implemented for the assessment and analysis of hazard related to active faults affecting the eastern and southern flanks of Mt. Etna. The system structure was developed in ArcGis® environment and consists of different thematic datasets that include spatially-referenced arc-features and associated database. Arc-type features, georeferenced into WGS84 Ellipsoid UTM zone 33 Projection, represent the five main fault systems that develop in the analysed region. The backbone of the GIS-based system is constituted by the large amount of information which was collected from the literature and then stored and properly geocoded in a digital database. This consists of thirty five alpha-numeric fields which include all fault parameters available from literature such us location, kinematics, landform, slip rate, etc. Although the system has been implemented according to the most common procedures used by GIS developer, the architecture and content of the database represent a pilot backbone for digital storing of fault parameters, providing a powerful tool in modelling hazard related to the active tectonics of Mt. Etna. The database collects, organises and shares all scientific currently available information about the active faults of the volcano. Furthermore, thanks to the strong effort spent on defining the fields of the database, the structure proposed in this paper is open to the collection of further data coming from future improvements in the knowledge of the fault systems. By layering additional user-specific geographic information and managing the proposed database (topological querying) a great diversity of hazard and vulnerability maps can be produced by the user. This is a proposal of a backbone for a comprehensive geographical database of fault systems, universally applicable to other sites.

  20. Active Subduction on Both Coasts of Costa Rica Does not Represent an Important Tsunami Hazard

    NASA Astrophysics Data System (ADS)

    Protti, M.; Gonzalez, V.

    2007-05-01

    Costa Rica, on the southern terminus of the Middle American Trench is being affected by active subduction on both, along the Pacific coast as well as on its Caribbean coast. Three main subduction segments can be recognized along the Pacific coast: 1) under northwestern Costa Rica, off Papagayo Gulf and Nicoya peninsula, the Cocos plate is subducting under the Caribbean plate; 2) under southern Costa Rica (Osa and Burica peninsulas) the Cocos plate subducts under the Panama Block and 3) in the central Pacific coast (between Nicoya and Osa peninsulas) the Cocos plate subducts under a shear zone that marks the transition between the Caribbean and the Cocos plate. Along the Caribbean coast, south of Puerto Limon, the Caribbean plate subducts under the Panama block. Large subduction earthquakes occur under the Nicoya peninsula, Osa peninsula and south of Limon. Most of the rupture area of these large events lies below land so the deformation of the ocean floor is minimal and therefore the tsunamis they generate are small. No large subduction earthquakes occur under the central Pacific coast of Costa Rica due to the subduction of small sea mounts that act as small asperities without potential to accumulate large amounts of slip. For this reason the region between Nicoya and Osa peninsulas is not an important tsunamigenic zone.

  1. Aerospace clinical psychology and its role in serving practitioners of hazardous activities.

    PubMed

    King, R

    1999-04-01

    Aerospace clinical psychology is defined as a special application of psychology to the hazardous and stressful occupations associated with aviation and space flight. Aerospace clinical psychological services usually are offered on a unit or organizational level, though interventions can be designed for individuals and their families. The application of aerospace clinical psychology to the "failing aviator" is described and the current status of the field is provided. The roles of flight surgeons and mental health providers are explained. Associations between poor pilot coping skills and failure at crew resource management are explored. Areas for future research are detailed.

  2. Standards Applicable to Generators of Hazardous Waste; Alternative Requirements for Hazardous Waste Determination and Accumulation of Unwanted Material at Laboratories Owned by Colleges and Universities and Other Eligible Academic Entities Formally Affiliated With Colleges and Universities. Final Rule. Federal Register, Environmental Protection Agency. 40 CFR Parts 261 and 262. Part II

    ERIC Educational Resources Information Center

    National Archives and Records Administration, 2008

    2008-01-01

    The Environmental Protection Agency (EPA or the Agency) is finalizing an alternative set of generator requirements applicable to laboratories owned by eligible academic entities, as defined in this final rule. The rule provides a flexible and protective set of regulations that address the specific nature of hazardous waste generation and…

  3. A Broadly-Based Training Program in Volcano Hazards Monitoring at the Center for the Study of Active Volcanoes

    NASA Astrophysics Data System (ADS)

    Thomas, D. M.; Bevens, D.

    2015-12-01

    The Center for the Study of Active Volcanoes, in cooperation with the USGS Volcano Hazards Program at HVO and CVO, offers a broadly based volcano hazards training program targeted toward scientists and technicians from developing nations. The program has been offered for 25 years and provides a hands-on introduction to a broad suite of volcano monitoring techniques, rather than detailed training with just one. The course content has evolved over the life of the program as the needs of the trainees have changed: initially emphasizing very basic monitoring techniques (e.g. precise leveling, interpretation of seismic drum records, etc.) but, as the level of sophistication of the trainees has increased, training in more advanced technologies has been added. Currently, topics of primary emphasis have included volcano seismology and seismic networks; acquisition and modeling of geodetic data; methods of analysis and monitoring of gas geochemistry; interpretation of volcanic deposits and landforms; training in LAHARZ, GIS mapping of lahar risks; and response to and management of volcanic crises. The course also provides training on public outreach, based on CSAV's Hawaii-specific hazards outreach programs, and volcano preparedness and interactions with the media during volcanic crises. It is an intensive eight week course with instruction and field activities underway 6 days per week; it is now offered in two locations, Hawaii Island, for six weeks, and the Cascades volcanoes of the Pacific Northwest, for two weeks, to enable trainees to experience field conditions in both basaltic and continental volcanic environments. The survival of the program for more than two decades demonstrates that a need for such training exists and there has been interaction and contribution to the program by the research community, however broader engagement with the latter continues to present challenges. Some of the reasons for this will be discussed.

  4. Atmospheric wind field conditions generated by active grids

    NASA Astrophysics Data System (ADS)

    Knebel, Pascal; Kittel, Achim; Peinke, Joachim

    2011-08-01

    An active grid for turbulence generation of several rotatable axes with surmounted vanes that can be driven via stepper or servo motors is presented. We investigate the impact of different excitation protocols for the grid. Using such protocols that already have the intermittent structure of turbulence, higher intermittent flows can be achieved. This concept can also be used to generate turbulent flows of high turbulence intensities (>25%) exhibiting integral length scales beyond the typical size of the test section of the wind tunnel. Similar two-point correlations measured by the intermittent statistics of velocity increments that are characteristic for flows of high Reynolds number, i.e. in the atmospheric boundary layer, can be reproduced.

  5. Reproductive Hazards

    MedlinePlus

    ... such as lead and mercury Chemicals such as pesticides Cigarettes Some viruses Alcohol For men, a reproductive hazard can affect the sperm. For a woman, a reproductive hazard can cause different effects during pregnancy, depending on when she is exposed. ...

  6. Studies on antistreptolysin O activity generated in serum by microorganisms.

    PubMed Central

    Watson, K. C.; Kerr, E. J.

    1976-01-01

    An antistreptolysin factor (ASF) was generated in normal human serum by the growth of Staph, aureus and Pseud, aeruginosa. Alpha toxin producing strains of the former were usually positive but activity was not restricted to such strains. Positive strains produce cholesterol esterase which was obtained from DEAE-cellulose column fractions of 18 h broth cultures. Antistreptolysin factor develops slowly in serum, being maximal between the 5th and 10th days and is associated with alterations and disappearance of beta lipoproteins on gel electrophoresis. Activity also appeared in beta lipoproteins precipitated from normal serum with dextran sulphate and redissolved in nutrient broth before inoculation with Staph, aureus. The slow appearance of antistreptolysin activity in serum appears to be due to an esterase inhibitor which is present in high concentrations in some sera. Activity is also modified by the production of a staphylococcal fraction capable of binding to the antistreptolysin factor and reducing its activity. It is suggested that antistreptolysin factor which can be demonstrated in small amounts in normal human serum represents a readily available non-specific defence mechanism capable of binding to certain bacterial products and possible to other foreign protein molecules. Images Fig. 2 PMID:178333

  7. 40 CFR 265.201 - Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Tank... storage of hazardous waste in tanks must comply with § 265.17(b). (2) Hazardous wastes or treatment... this inflow (e.g., waste feed cutoff system or by-pass system to a stand-by tank). Note: These...

  8. 40 CFR 265.201 - Special requirements for generators of between 100 and 1,000 kg/mo that accumulate hazardous...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Tank... storage of hazardous waste in tanks must comply with § 265.17(b). (2) Hazardous wastes or treatment... this inflow (e.g., waste feed cutoff system or by-pass system to a stand-by tank). Note: These...

  9. An exploratory propensity score matched comparison of second-generation and first-generation baroreflex activation therapy systems.

    PubMed

    Wachter, Rolf; Halbach, Marcel; Bakris, George L; Bisognano, John D; Haller, Hermann; Beige, Joachim; Kroon, Abraham A; Nadim, Mitra K; Lovett, Eric G; Schafer, Jill E; de Leeuw, Peter W

    2016-12-16

    Baroreflex activation therapy (BAT) is a device-based therapy for patients with treatment-resistant hypertension. In a randomized, controlled trial, the first-generation system significantly reduced blood pressure (BP) versus sham. Although an open-label validation study of the second-generation system demonstrated similar BP reductions, controlled data are not presently available. Therefore, this investigation compares results of first- and second-generation BAT systems. Two cohorts of first-generation BAT system patients were generated with propensity matching to compare against the validation group of 30 second-generation subjects. The first cohort was drawn from the first-generation randomized trial sham group and the second cohort from the active therapy group. Safety and efficacy were compared for the second-generation group relative to the first generation. At 6 months, second-generation BAT outperformed first-generation sham systolic BP reduction by 20 ± 28 mm Hg (mean ± standard deviation, P = .008), while BP reduction in first- and second-generation active groups was similar. At 12 months, efficacy was comparable between all three groups after the sham group had received 6 months of therapy; 47% of second-generation patients achieved goal systolic BP of 140 mm Hg or less after 12 months, comparable to 50% of patients at goal in the first-generation group (P > .999). Implant procedure time, system/procedural safety, and pulse generator longevity improved with the second-generation system. Propensity-matched cohort analysis of the first- and second-generation BAT systems suggests similar therapeutic benefit and superior BP reduction of the second-generation system relative to sham control. Implantation procedure duration and perioperative safety were improved with the second-generation device. These findings should be validated in a prospective randomized trial.

  10. A probabilistic tsunami hazard assessment for Indonesia

    NASA Astrophysics Data System (ADS)

    Horspool, N.; Pranantyo, I.; Griffin, J.; Latief, H.; Natawidjaja, D. H.; Kongko, W.; Cipta, A.; Bustaman, B.; Anugrah, S. D.; Thio, H. K.

    2014-11-01

    Probabilistic hazard assessments are a fundamental tool for assessing the threats posed by hazards to communities and are important for underpinning evidence-based decision-making regarding risk mitigation activities. Indonesia has been the focus of intense tsunami risk mitigation efforts following the 2004 Indian Ocean tsunami, but this has been largely concentrated on the Sunda Arc with little attention to other tsunami prone areas of the country such as eastern Indonesia. We present the first nationally consistent probabilistic tsunami hazard assessment (PTHA) for Indonesia. This assessment produces time-independent forecasts of tsunami hazards at the coast using data from tsunami generated by local, regional and distant earthquake sources. The methodology is based on the established monte carlo approach to probabilistic seismic hazard assessment (PSHA) and has been adapted to tsunami. We account for sources of epistemic and aleatory uncertainty in the analysis through the use of logic trees and sampling probability density functions. For short return periods (100 years) the highest tsunami hazard is the west coast of Sumatra, south coast of Java and the north coast of Papua. For longer return periods (500-2500 years), the tsunami hazard is highest along the Sunda Arc, reflecting the larger maximum magnitudes. The annual probability of experiencing a tsunami with a height of > 0.5 m at the coast is greater than 10% for Sumatra, Java, the Sunda islands (Bali, Lombok, Flores, Sumba) and north Papua. The annual probability of experiencing a tsunami with a height of > 3.0 m, which would cause significant inundation and fatalities, is 1-10% in Sumatra, Java, Bali, Lombok and north Papua, and 0.1-1% for north Sulawesi, Seram and Flores. The results of this national-scale hazard assessment provide evidence for disaster managers to prioritise regions for risk mitigation activities and/or more detailed hazard or risk assessment.

  11. A statistical method linking geological and historical eruption time series for volcanic hazard estimations: Applications to active polygenetic volcanoes

    NASA Astrophysics Data System (ADS)

    Mendoza-Rosas, Ana Teresa; De la Cruz-Reyna, Servando

    2008-09-01

    The probabilistic analysis of volcanic eruption time series is an essential step for the assessment of volcanic hazard and risk. Such series describe complex processes involving different types of eruptions over different time scales. A statistical method linking geological and historical eruption time series is proposed for calculating the probabilities of future eruptions. The first step of the analysis is to characterize the eruptions by their magnitudes. As is the case in most natural phenomena, lower magnitude events are more frequent, and the behavior of the eruption series may be biased by such events. On the other hand, eruptive series are commonly studied using conventional statistics and treated as homogeneous Poisson processes. However, time-dependent series, or sequences including rare or extreme events, represented by very few data of large eruptions require special methods of analysis, such as the extreme-value theory applied to non-homogeneous Poisson processes. Here we propose a general methodology for analyzing such processes attempting to obtain better estimates of the volcanic hazard. This is done in three steps: Firstly, the historical eruptive series is complemented with the available geological eruption data. The linking of these series is done assuming an inverse relationship between the eruption magnitudes and the occurrence rate of each magnitude class. Secondly, we perform a Weibull analysis of the distribution of repose time between successive eruptions. Thirdly, the linked eruption series are analyzed as a non-homogeneous Poisson process with a generalized Pareto distribution as intensity function. As an application, the method is tested on the eruption series of five active polygenetic Mexican volcanoes: Colima, Citlaltépetl, Nevado de Toluca, Popocatépetl and El Chichón, to obtain hazard estimates.

  12. Volcanology and volcanic activity with a primary focus on potential hazard impacts for the Hawaii geothermal project

    SciTech Connect

    Moore, R.B.; Delaney, P.T.; Kauahikaua, J.P.

    1993-10-01

    This annotated bibliography reviews published references about potential volcanic hazards on the Island of Hawaii that are pertinent to drilling and operating geothermal wells. The first two sections of this annotated bibliography list the most important publications that describe eruptions of Kilauea volcano, with special emphasis on activity in and near the designated geothermal subzones. References about historic eruptions from Mauna Loa`s northeast rift zone, as well as the most recent activity on the southern flank of dormant Mauna Kea, adjacent to the Humu`ula Saddle are described. The last section of this annotated bibliography lists the most important publications that describe and analyze deformations of the surface of Kilauea and Mauna Loa volcanoes.

  13. Active control of fan-generated plane wave noise

    NASA Astrophysics Data System (ADS)

    Gerhold, Carl H.; Nuckolls, William E.; Santamaria, Odillyn L.; Martinson, Scott D.

    1993-08-01

    Subsonic propulsion systems for future aircraft may incorporate ultra-high bypass ratio ducted fan engines whose dominant noise source is the fan with blade passage frequency less than 1000 Hz. This low frequency combines with the requirement of a short nacelle to diminish the effectiveness of passive duct liners. Active noise control is seen as a viable method to augment the conventional passive treatments. An experiment to control ducted fan noise using a time domain active adaptive system is reported. The control sound source consists of loudspeakers arrayed around the fan duct. The error sensor location is in the fan duct. The purpose of this experiment is to demonstrate that the in-duct error sensor reduces the mode spillover in the far field, thereby increasing the efficiency of the control system. In this first series of tests, the fan is configured so that predominantly zero order circumferential waves are generated. The control system is found to reduce the blade passage frequency tone significantly in the acoustic far field when the mode orders of the noise source and of the control source are the same. The noise reduction is not as great when the mode orders are not the same even though the noise source modes are evanescent, but the control system converges stably and global noise reduction is demonstrated in the far field. Further experimentation is planned in which the performance of the system will be evaluated when higher order radial and spinning modes are generated.

  14. Experimental generation of single photons via active multiplexing

    SciTech Connect

    Ma Xiaosong; Zotter, Stefan; Kofler, Johannes; Jennewein, Thomas; Zeilinger, Anton

    2011-04-15

    An on-demand single-photon source is a fundamental building block in quantum science and technology. We experimentally demonstrate the proof of concept for a scheme to generate on-demand single photons via actively multiplexing several heralded photons probabilistically produced from pulsed spontaneous parametric down-conversions (SPDCs). By utilizing a four-photon-pair source, an active feed-forward technique, and an ultrafast single-photon router, we show a fourfold enhancement of the output photon rate. Simultaneously, we maintain the quality of the output single-photon states, confirmed by correlation measurements. We also experimentally verify, via Hong-Ou-Mandel interference, that the router does not affect the indistinguishability of the single photons. Furthermore, we give numerical simulations, which indicate that photons based on multiplexing of four SPDC sources can outperform the heralding based on highly advanced photon-number-resolving detectors. Our results show a route for on-demand single-photon generation and the practical realization of scalable linear optical quantum-information processing.

  15. Active control of fan-generated plane wave noise

    NASA Technical Reports Server (NTRS)

    Gerhold, Carl H.; Nuckolls, William E.; Santamaria, Odillyn L.; Martinson, Scott D.

    1993-01-01

    Subsonic propulsion systems for future aircraft may incorporate ultra-high bypass ratio ducted fan engines whose dominant noise source is the fan with blade passage frequency less than 1000 Hz. This low frequency combines with the requirement of a short nacelle to diminish the effectiveness of passive duct liners. Active noise control is seen as a viable method to augment the conventional passive treatments. An experiment to control ducted fan noise using a time domain active adaptive system is reported. The control sound source consists of loudspeakers arrayed around the fan duct. The error sensor location is in the fan duct. The purpose of this experiment is to demonstrate that the in-duct error sensor reduces the mode spillover in the far field, thereby increasing the efficiency of the control system. In this first series of tests, the fan is configured so that predominantly zero order circumferential waves are generated. The control system is found to reduce the blade passage frequency tone significantly in the acoustic far field when the mode orders of the noise source and of the control source are the same. The noise reduction is not as great when the mode orders are not the same even though the noise source modes are evanescent, but the control system converges stably and global noise reduction is demonstrated in the far field. Further experimentation is planned in which the performance of the system will be evaluated when higher order radial and spinning modes are generated.

  16. Contact system activation and high thrombin generation in hyperthyroidism.

    PubMed

    Kim, Namhee; Gu, Ja-Yoon; Yoo, Hyun Ju; Han, Se Eun; Kim, Young Il; Nam-Goong, Il Seong; Kim, Eun Sook; Kim, Hyun Kyung

    2017-01-30

    Background Hyperthyroidism is associated with increased thrombotic risk. Since contact system activation through formation of neutrophil extracellular traps (NET) has emerged as an important trigger of thrombosis, we hypothesized that the contact system is activated along with active NET formation in hyperthyroidism and that their markers correlate with disease severity. Materials and Methods In 61 patients with hyperthyroidism and 40 normal controls, the levels of coagulation factors (fibrinogen, and factor VII, VIII, IX, XI, and XII), D-dimer, thrombin generation assay (TGA) markers, NET formation markers (histone-DNA complex, double-stranded DNA, neutrophil elastase), and contact system markers (activated factor XII [XIIa], high-molecular-weight kininogen [HMWK], prekallikrein, and bradykinin) were measured. Results Patients with hyperthyroidism showed higher levels of fibrinogen [median (interquartile range), 315 (280-344) versus 262 (223-300), P=0.001], D-dimer [103.8 (64.8-151.5) versus 50.7 (37.4-76.0), P<0.001], peak thrombin [131.9 (102.2-159.4) versus 31.6 (14.8-83.7), P<0.001] and endogenous thrombin potential [649 (538-736) versus 367 (197-1147), P=0.021] in TGA with 1 pM tissue factor, neutrophil elastase [1.10 (0.39-2.18) versus 0.23 (0.20-0.35), P<0.001], factor XIIa [66.9 (52.8-87.0) versus 73.0 (57.1-86.6), P<0.001], HMWK [6.11 (4.95-7.98) versus 3.83 (2.60-5.68), P<0.001], prekallikrein [2.15 (1.00-6.36) versus 1.41 (0.63-2.22), P=0.026], and bradykinin [152.4 (137.6-180.4) versus 118.3 (97.1-137.9), P<0.001] than did normal controls. In age- and sex-adjusted logistic regression analysis, fibrinogen, factor VIII, IX, and XIIa, D-dimer, peak thrombin, neutrophil elastase, HMWK, and bradykinin showed significant odds ratios representing hyperthyroidism's contribution to coagulation and contact system activation. Free T4 was significantly correlated with factors VIII and IX, D-dimer, double-stranded DNA, and bradykinin. Conclusion This study

  17. Connection between solar activity cycles and grand minima generation

    NASA Astrophysics Data System (ADS)

    Vecchio, A.; Lepreti, F.; Laurenza, M.; Alberti, T.; Carbone, V.

    2017-03-01

    Aims: The revised dataset of sunspot and group numbers (released by WDC-SILSO) and the sunspot number reconstruction based on dendrochronologically dated radiocarbon concentrations have been analyzed to provide a deeper characterization of the solar activity main periodicities and to investigate the role of the Gleissberg and Suess cycles in the grand minima occurrence. Methods: Empirical mode decomposition (EMD) has been used to isolate the time behavior of the different solar activity periodicities. A general consistency among the results from all the analyzed datasets verifies the reliability of the EMD approach. Results: The analysis on the revised sunspot data indicates that the highest energy content is associated with the Schwabe cycle. In correspondence with the grand minima (Maunder and Dalton), the frequency of this cycle changes to longer timescales of 14 yr. The Gleissberg and Suess cycles, with timescales of 60-120 yr and 200-300 yr, respectively, represent the most energetic contribution to sunspot number reconstruction records and are both found to be characterized by multiple scales of oscillation. The grand minima generation and the origin of the two expected distinct types of grand minima, Maunder and longer Spörer-like, are naturally explained through the EMD approach. We found that the grand minima sequence is produced by the coupling between Gleissberg and Suess cycles, the latter being responsible for the most intense and longest Spörer-like minima (with typical duration longer than 80 yr). Finally, we identified a non-solar component, characterized by a very long scale oscillation of 7000 yr, and the Hallstatt cycle ( 2000 yr), likely due to the solar activity. Conclusions: These results provide new observational constraints on the properties of the solar cycle periodicities, the grand minima generation, and thus the long-term behavior of the solar dynamo.

  18. Approach to using mechanism-based structure activity relationship (SAR) analysis to assess human health hazard potential of nanomaterials.

    PubMed

    Lai, David Y

    2015-11-01

    With the increasing use and development of engineered nanoparticles in electronics, consumer products, pesticides, food and pharmaceutical industries, there is a growing concern about potential human health hazards of these materials. A number of studies have demonstrated that nanoparticle toxicity is extremely complex, and that the biological activity of nanoparticles will depend on a variety of physicochemical properties such as particle size, shape, agglomeration state, crystal structure, chemical composition, surface area and surface properties. Nanoparticle toxicity can be attributed to nonspecific interaction with biological structures due to their physical properties (e.g., size and shape) and biopersistence, or to specific interaction with biomolecules through their surface properties (e.g., surface chemistry and reactivity) or release of toxic ions. The toxic effects of most nanomaterials have not been adequately characterized and currently, there are many issues and challenges in toxicity testing and risk assessment of nanoparticles. Based on the possible mechanisms of action and available in vitro and in vivo toxicity database, this paper proposes an approach to using mechanism-based SAR analysis to assess the relative human health hazard/risk potential of various types of nanomaterials.

  19. Active crustal deformation of the El Salvador Fault Zone (ESFZ) using GPS data: Implications in seismic hazard assessment

    NASA Astrophysics Data System (ADS)

    Staller, Alejandra; Benito, Belen; Jesús Martínez-Díaz, José; Hernández, Douglas; Hernández-Rey, Román; Alonso-Henar, Jorge

    2014-05-01

    El Salvador, Central America, is part of the Chortis block in the northwestern boundary of the Caribbean plate. This block is interacting with a diffuse triple junction point with the Cocos and North American plates. Among the structures that cut the Miocene to Pleistocene volcanic deposits stands out the El Salvador Fault Zone (ESFZ): It is oriented in N90º-100ºE direction, and it is composed of several structural segments that deform Quaternary deposits with right-lateral and oblique slip motions. The ESFZ is seismically active and capable of producing earthquakes such as the February 13, 2001 with Mw 6.6 (Martínez-Díaz et al., 2004), that seriously affected the population, leaving many casualties. This structure plays an important role in the tectonics of the Chortis block, since its motion is directly related to the drift of the Caribbean plate to the east and not with the partitioning of the deformation of the Cocos subduction (here not coupled) (Álvarez-Gómez et al., 2008). Together with the volcanic arc of El Salvador, this zone constitutes a weakness area that allows the motion of forearc block toward the NW. The geometry and the degree of activity of the ESFZ are not studied enough. However their knowledge is essential to understand the seismic hazard associated to this important seismogenic structure. For this reason, since 2007 a GPS dense network was established along the ESFZ (ZFESNet) in order to obtain GPS velocity measurements which are later used to explain the nature of strain accumulation on major faults along the ESFZ. The current work aims at understanding active crustal deformation of the ESFZ through kinematic model. The results provide significant information to be included in a new estimation of seismic hazard taking into account the major structures in ESFZ.

  20. Using the Global Navigation Satellite System (GNSS) data for Hazard Estimation in Some Active Regions in Egypt

    NASA Astrophysics Data System (ADS)

    Sayed Mohamed, Abdel-Monem

    2016-07-01

    Egypt rapidly growing development is accompanied by increasing levels of standard living particular in its urban areas. However, there is a limited experience in quantifying the sources of risk management in Egypt and in designing efficient strategies to keep away serious impacts of earthquakes. From the historical point of view and recent instrumental records, there are some seismo-active regions in Egypt, where some significant earthquakes had occurred in different places. The special tectonic features in Egypt: Aswan, Greater Cairo, Red Sea and Sinai Peninsula regions are the territories of a high seismic risk, which have to be monitored by up-to date technologies. The investigations of the seismic events and interpretations led to evaluate the seismic hazard for disaster prevention and for the safety of the dense populated regions and the vital national projects as the High Dam. In addition to the monitoring of the recent crustal movements, the most powerful technique of satellite geodesy GNSS are used where geodetic networks are covering such seismo-active regions. The results from the data sets are compared and combined in order to determine the main characteristics of the deformation and hazard estimation for specified regions. The final compiled output from the seismological and geodetic analysis threw lights upon the geodynamical regime of these seismo-active regions and put Aswan and Greater Cairo under the lowest class according to horizontal crustal strains classifications. This work will serve a basis for the development of so-called catastrophic models and can be further used for catastrophic risk management. Also, this work is trying to evaluate risk of large catastrophic losses within the important regions including the High Dam, strategic buildings and archeological sites. Studies on possible scenarios of earthquakes and losses are a critical issue for decision making in insurance as a part of mitigation measures.

  1. Enumerating Minimal Active Metabolic Pathways by Model Generation

    NASA Astrophysics Data System (ADS)

    Soh, Takehide; Inoue, Katsumi

    In systems biology, identifying vital functions like glycolysis from a given metabolic pathway is important to understand living organisms. In this paper, we particularly focus on the problem of enumerating minimal active pathways producing target metabolites from source metabolites. We represent the problem in propositional formulas and solve it through minimal model generation. An advantage of our method is that each solution satisfies qualitative laws of biochemical reactions. Moreover, we can calculate such solutions for a cellular scale metabolic pathway within a few seconds. In experiments, we have applied our method to a whole Escherichia coli metabolic pathway. As a result, we found a minimal set of reactions corresponding to the conventional glycolysis pathway described in a biological database EcoCyc.

  2. Microfluidic Platform Generates Oxygen Landscapes for Localized Hypoxic Activation

    PubMed Central

    Rexius, Megan L.; Mauleon, Gerardo; Malik, Asrar B.; Rehman, Jalees; Eddington, David T.

    2014-01-01

    An open-well microfluidic platform generates an oxygen landscape using gas-perfused networks which diffuse across a membrane. The device enables real-time analysis of cellular and tissue responses to oxygen tension to define how cells adapt to heterogeneous oxygen conditions found in the physiological setting. We demonstrate that localized hypoxic activation of cells elicited specific metabolic and gene responses in human microvascular endothelial cells and bone marrow-derived mesenchymal stem cells. A robust demonstration of the compatibility of the device with standard laboratory techniques demonstrates the wide utility of the method. This platform is ideally suited to study real-time cell responses and cell-cell interactions within physiologically relevant oxygen landscapes. PMID:25315003

  3. Microfluidic platform generates oxygen landscapes for localized hypoxic activation.

    PubMed

    Rexius-Hall, Megan L; Mauleon, Gerardo; Malik, Asrar B; Rehman, Jalees; Eddington, David T

    2014-12-21

    An open-well microfluidic platform generates an oxygen landscape using gas-perfused networks which diffuse across a membrane. The device enables real-time analysis of cellular and tissue responses to oxygen tension to define how cells adapt to heterogeneous oxygen conditions found in the physiological setting. We demonstrate that localized hypoxic activation of cells elicited specific metabolic and gene responses in human microvascular endothelial cells and bone marrow-derived mesenchymal stem cells. A robust demonstration of the compatibility of the device with standard laboratory techniques demonstrates the wide utility of the method. This platform is ideally suited to study real-time cell responses and cell-cell interactions within physiologically relevant oxygen landscapes.

  4. Anti-prion activity generated by a novel vaccine formulation.

    PubMed

    Pilon, John; Loiacono, Christina; Okeson, Danelle; Lund, Sharon; Vercauteren, Kurt; Rhyan, Jack; Miller, Lowell

    2007-12-18

    Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of domestic and wild cervids in North America. To address possible prevention regimens for CWD, we have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential vaccine candidates. Three peptides derived from the primary amino acid sequence of the prion protein were conjugated to blue carrier protein (BCP) and formulated in an adjuvant containing M. avium subsp. avium. CL57/BL6 mice were vaccinated and boosted with 50 microg of the carrier protein-peptide conjugate formulation; all vaccines produced a humoral immune response as measured by ELISA. Disease challenge with the RML scrapie prion strain revealed anti-prion activity was generated by the vaccine formulations as measured by a delay in clinical disease onset and prolonged survivorship.

  5. A sinuous tumulus over an active lava tube at Kīlauea Volcano: Evolution, analogs, and hazard forecasts

    NASA Astrophysics Data System (ADS)

    Orr, Tim R.; Bleacher, Jacob E.; Patrick, Matthew R.; Wooten, Kelly M.

    2015-01-01

    Inflation of narrow tube-fed basaltic lava flows (tens of meters across), such as those confined by topography, can be focused predominantly along the roof of a lava tube. This can lead to the development of an unusually long tumulus, its shape matching the sinuosity of the underlying lava tube. Such a situation occurred during Kīlauea Volcano's (Hawai'i, USA) ongoing East Rift Zone eruption on a lava tube active from July through November 2010. Short-lived breakouts from the tube buried the flanks of the sinuous, ridge-like tumulus, while the tumulus crest, its surface composed of lava formed very early in the flow's emplacement history, remained poised above the surrounding younger flows. At least several of these breakouts resulted in irrecoverable uplift of the tube roof. Confined sections of the prehistoric Carrizozo and McCartys flows (New Mexico, USA) display similar sinuous, ridge-like features with comparable surface age relationships. We contend that these distinct features formed in a fashion equivalent to that of the sinuous tumulus that formed at Kīlauea in 2010. Moreover, these sinuous tumuli may be analogs for some sinuous ridges evident in orbital images of the Tharsis volcanic province on Mars. The short-lived breakouts from the sinuous tumulus at Kīlauea were caused by surges in discharge through the lava tube, in response to cycles of deflation and inflation (DI events) at Kīlauea's summit. The correlation between DI events and subsequent breakouts aided in lava flow forecasting. Breakouts from the sinuous tumulus advanced repeatedly toward the sparsely populated Kalapana Gardens subdivision, destroying two homes and threatening others. Hazard assessments, including flow occurrence and advance forecasts, were relayed regularly to the Hawai'i County Civil Defense to aid their lava flow hazard mitigation efforts while this lava tube was active.

  6. A sinuous tumulus over an active lava tube at Kīlauea Volcano: evolution, analogs, and hazard forecasts

    USGS Publications Warehouse

    Orr, Tim R.; Bleacher, Jacob E.; Patrick, Matthew R.; Wooten, Kelly M.

    2015-01-01

    Inflation of narrow tube-fed basaltic lava flows (tens of meters across), such as those confined by topography, can be focused predominantly along the roof of a lava tube. This can lead to the development of an unusually long tumulus, its shape matching the sinuosity of the underlying lava tube. Such a situation occurred during Kīlauea Volcano's (Hawai'i, USA) ongoing East Rift Zone eruption on a lava tube active from July through November 2010. Short-lived breakouts from the tube buried the flanks of the sinuous, ridge-like tumulus, while the tumulus crest, its surface composed of lava formed very early in the flow's emplacement history, remained poised above the surrounding younger flows. At least several of these breakouts resulted in irrecoverable uplift of the tube roof. Confined sections of the prehistoric Carrizozo and McCartys flows (New Mexico, USA) display similar sinuous, ridge-like features with comparable surface age relationships. We contend that these distinct features formed in a fashion equivalent to that of the sinuous tumulus that formed at Kīlauea in 2010. Moreover, these sinuous tumuli may be analogs for some sinuous ridges evident in orbital images of the Tharsis volcanic province on Mars. The short-lived breakouts from the sinuous tumulus at Kīlauea were caused by surges in discharge through the lava tube, in response to cycles of deflation and inflation (DI events) at Kīlauea's summit. The correlation between DI events and subsequent breakouts aided in lava flow forecasting. Breakouts from the sinuous tumulus advanced repeatedly toward the sparsely populated Kalapana Gardens subdivision, destroying two homes and threatening others. Hazard assessments, including flow occurrence and advance forecasts, were relayed regularly to the Hawai'i County Civil Defense to aid their lava flow hazard mitigation efforts while this lava tube was active.

  7. Landslide Hazards

    USGS Publications Warehouse

    ,

    2000-01-01

    Landslide hazards occur in many places around What Can You Do If You Live Near Steep Hills? the world and include fast-moving debris flows, slow-moving landslides, and a variety of flows and slides initiating from volcanoes. Each year, these hazards cost billions of dollars and cause numerous fatalities and injuries. Awareness and education about these hazards is a first step toward reducing damaging effects. The U.S. Geological Survey conducts research and distributes information about geologic hazards. This Fact Sheet is published in English and Spanish and can be reproduced in any form for further distribution. 

  8. Active shortening of the Cascadia forearc and implications for seismic hazards of the Puget Lowland

    USGS Publications Warehouse

    Johnson, S.Y.; Blakely, R.J.; Stephenson, W.J.; Dadisman, S.V.; Fisher, M.A.

    2004-01-01

    Margin-parallel shortening of the Cascadia forearc is a consequence of oblique subduction of the Juan de Fuca plate beneath North America. Strike-slip, thrust, and oblique crustal faults beneath the densely populated Puget Lowland accommodate much of this north-south compression, resulting in large crustal earthquakes. To better understand this forearc deformation and improve earthquake hazard, assessment, we here use seismic reflection surveys, coastal exposures of Pleistocene strata, potential-field data, and airborne laser swath mapping to document and interpret a significant structural boundary near the City of Tacoma. This boundary is a complex structural zone characterized by two distinct segments. The northwest trending, eastern segment, extending from Tacoma to Carr Inlet, is formed by the broad (??? 11.5 km), southwest dipping (??? 11??-2??) Rosedale monocline. This monocline raises Crescent Formation basement about 2.5 km, resulting in a moderate gravity gradient. We interpret the Rosedale monocline as a fault-bend fold, forming above a deep thrust fault. Within the Rosedale monocline, inferred Quaternary strata thin northward and form a growth triangle that is 4.1 to 6.6 km wide at its base, suggesting ??? 2-3 mm/yr of slip on the underlying thrust. The western section of the >40-km-long, north dipping Tacoma fault, extending from Hood Canal to Carr Inlet, forms the western segment of the Tacoma basin margin. Structural relief on this portion of the basin margin may be several kilometers, resulting in steep gravity and aeromagnetic anomalies. Quaternary structural relief along the Tacoma fault is as much as 350-400 m, indicating a minimum slip rate of about 0.2 mm/yr. The inferred eastern section of the Tacoma fault (east of Carr Inlet) crosses the southern part of the Seattle uplift, has variable geometry along strike, and diminished structural relief. The Tacoma fault is regarded as a north dipping backthrust to the Seattle fault, so that slip on a

  9. ActivitySim: large-scale agent based activity generation for infrastructure simulation

    SciTech Connect

    Gali, Emmanuel; Eidenbenz, Stephan; Mniszewski, Sue; Cuellar, Leticia; Teuscher, Christof

    2008-01-01

    The United States' Department of Homeland Security aims to model, simulate, and analyze critical infrastructure and their interdependencies across multiple sectors such as electric power, telecommunications, water distribution, transportation, etc. We introduce ActivitySim, an activity simulator for a population of millions of individual agents each characterized by a set of demographic attributes that is based on US census data. ActivitySim generates daily schedules for each agent that consists of a sequence of activities, such as sleeping, shopping, working etc., each being scheduled at a geographic location, such as businesses or private residences that is appropriate for the activity type and for the personal situation of the agent. ActivitySim has been developed as part of a larger effort to understand the interdependencies among national infrastructure networks and their demand profiles that emerge from the different activities of individuals in baseline scenarios as well as emergency scenarios, such as hurricane evacuations. We present the scalable software engineering principles underlying ActivitySim, the socia-technical modeling paradigms that drive the activity generation, and proof-of-principle results for a scenario in the Twin Cities, MN area of 2.6 M agents.

  10. Immobilized-cell-augmented activated sludge process for treating wastewater containing hazardous compounds.

    PubMed

    Jittawattanarat, Rungrod; Kostarelos, Konstantinos; Khan, Eakalak

    2007-05-01

    A novel bioaugmentation scheme called immobilized-cell-augmented activated sludge (ICAAS) was developed. Offline enricher reactors were used to maintain immobilized acclimated cells applied to augment completely mixed activated sludge (CMAS) treating a pentachlorophenol (PCP) pulse loading. Cellulose triacetate (CA) and powder activated carbon (PAC) combined with CA (PAC + CA) were the two media types used for entrapping the PCP-degrading culture. With ICAAS at 5% by volume augmentation, PCP removal of 73.1 and 75.1% via biodegradation, volatilization, and adsorption onto suspended cells, entrapped cells, and media was achieved for the systems with CA and PAC + CA media, respectively, while PCP removal in a control CMAS, which had a comparable level of combined PCP adsorption onto suspended cells and volatilization as the ICAAS, was 48.7%. Results further showed that the immobilized cells retained their PCP-degrading ability when they were fed with the inducer (PCP) once every 20 days.

  11. An Analysis of Generational Differences Among Active Duty Members

    DTIC Science & Technology

    2004-03-01

    political , and racial lenses. Therefore, it may be difficult to point to an absolute generational group that is defined by a set of shared...group as those born between 1965 and 1978. Finally, the newest generation born after 1979, the Millennials , often given the label Generation Y or Echo...computer technology. Howe and Strauss (2000) define the Millennials as the generation born between 1982 and 2000. The Millennial Cohort, as defined by

  12. Hazardous Waste Environmental Education Resource Kit for Manitoba Teachers: Suggested Activities K-12.

    ERIC Educational Resources Information Center

    Downey-Franchuk, Andrea J.

    Society has become increasingly aware of the harmful effects that the disposal of chemical waste products have on the environment and human health. Public information is central to the development of a responsible waste management plan. The activities contained in this guide are organized in sequence from kindergarten to grade 12, and provide…

  13. Marine and land active-source seismic investigation of geothermal potential, tectonic structure, and earthquake hazards in Pyramid Lake, Nevada

    NASA Astrophysics Data System (ADS)

    Eisses, A.; Kell, A. M.; Kent, G.; Driscoll, N. W.; Karlin, R. E.; Baskin, R. L.; Louie, J. N.; Smith, K. D.; Pullammanappallil, S.

    2011-12-01

    Preliminary slip rates measured across the East Pyramid Lake fault, or the Lake Range fault, help provide new estimates of extension across the Pyramid Lake basin. Multiple stratigraphic horizons spanning 48 ka were tracked throughout the lake, with layer offsets measured across all significant faults in the basin. A chronstratigraphic framework acquired from four sediment cores allows slip rates of the Lake Range and other faults to be calculated accurately. This region of the northern Walker Lake, strategically placed between the right-lateral strike-slip faults of Honey and Eagle Lakes to the north, and the normal fault bounded basins to the southwest (e.g., Tahoe, Carson), is critical in understanding the underlying structural complexity that is not only necessary for geothermal exploration, but also earthquake hazard assessment due to the proximity of the Reno-Sparks metropolitan area. In addition, our seismic CHIRP imaging with submeter resolution allows the construction of the first fault map of Pyramid Lake. The Lake Range fault can be obviously traced west of Anahoe Island extending north along the east end of the lake in numerous CHIRP lines. Initial drafts of the fault map reveal active transtension through a series of numerous, small, northwest striking, oblique-slip faults in the north end of the lake. A previously field mapped northwest striking fault near Sutcliff can be extended into the west end of Pyramid Lake. This fault map, along with the calculated slip rate of the Lake Range, and potentially multiple other faults, gives a clearer picture into understanding the geothermal potential, tectonic regime and earthquake hazards in the Pyramid Lake basin and the northern Walker Lane. These new results have also been merged with seismicity maps, along with focal mechanisms for the larger events to begin to extend our fault map in depth.

  14. Variable phase sine wave generator for active phased arrays

    NASA Astrophysics Data System (ADS)

    Waters, W. M.

    1992-09-01

    A waveform generator is provided for generating a high frequency waveform. A pulse generator provides a pulse train at a low frequency. A pulse converter converts the pulse train into an alternatingly positive and negative groups of pulses. A bandpass filter passes the alternatingly positive and negative groups of pulses in a frequency band centered at the high frequency to output the generated waveform at the high frequency. When the groups of pulses are a pair of pulses, a sine wave is output from the bandpass filter. A pulse delay circuit can be used to variably delay the pulse train and thereby cause a phase change in the generated waveform.

  15. Automated Standard Hazard Tool

    NASA Technical Reports Server (NTRS)

    Stebler, Shane

    2014-01-01

    The current system used to generate standard hazard reports is considered cumbersome and iterative. This study defines a structure for this system's process in a clear, algorithmic way so that standard hazard reports and basic hazard analysis may be completed using a centralized, web-based computer application. To accomplish this task, a test server is used to host a prototype of the tool during development. The prototype is configured to easily integrate into NASA's current server systems with minimal alteration. Additionally, the tool is easily updated and provides NASA with a system that may grow to accommodate future requirements and possibly, different applications. Results of this project's success are outlined in positive, subjective reviews complete by payload providers and NASA Safety and Mission Assurance personnel. Ideally, this prototype will increase interest in the concept of standard hazard automation and lead to the full-scale production of a user-ready application.

  16. Active Control of Fan-Generated Tone Noise

    NASA Technical Reports Server (NTRS)

    Gerhold, Carl H.

    1995-01-01

    This paper reports on an experiment to control the noise radiated from the inlet of a ducted fan using a time domain active adaptive system. The control ,sound source consists of loudspeakers arranged in a ring around the fan duct. The error sensor location is in the fan duct. The purpose of this experiment is to demonstrate that the in-duct error sensor reduces the mode spillover in the far field, thereby increasing the efficiency of the control system. The control system is found to reduce the blade passage frequency tone significantly in the acoustic far field when the mode orders of the noise source and of the control source are the same, when the dominant wave in the duct is a plane wave. The presence of higher order modes in the duct reduces the noise reduction efficiency, particularly near the mode cut-on where the standing wave component is strong, but the control system converges stably. The control system is stable and converges when the first circumferential mode is generated in the duct. The control system is found to reduce the fan noise in the far field on an arc around the fan inlet by as much as 20 dB with none of the sound amplification associated with mode spillover.

  17. On the aerodynamics and performance of active vortex generators

    NASA Technical Reports Server (NTRS)

    Barrett, Ron; Farokhi, Saeed

    1993-01-01

    As a building block in the development of smart lift-enhancement devices, a new concept for flow control using active vortex generators (AVGs) is presented. Ramp, wedge, and doublet wedge (Wheeler) VG configurations are investigated. The AVGs are designed to conform to the surface of the wing section at low alpha. As the section approaches the stall, they are deployed and accordingly, alpha(stall) and C(lmax) are increased. A qualitative analysis of the flow around the various VG configurations was conducted in a low speed wind tunnel at 1.6 ft/s and a Reynolds number of approximately 3400. The results demonstrate that ramp VGs produce vortices that have the longest distance at breakdown. The VGs were also applied to a 25-in. span, 8-in. chord NACA 4415 wing section. Optimization studies were conducted on the spanwise spacing, chordwise position, and size of statically deployed VGs. The test results demonstrate a 14-percent increase in C(lmax) while increasing alpha (stall) by up to 3.

  18. The effects of aging on the dynamic adsorption of hazardous organic vapors on impregnated activated carbon.

    PubMed

    Amitay-Rosen, Tal; Leibman, Amir; Nir, Ido; Zaltsman, Amalia; Kaplan, Doron

    2015-01-01

    The effects of an eight-year natural aging of ASC impregnated activated carbon on the adsorption capacity and breakthrough times of model organic vapors and of the nerve agent sarin were investigated. Aging delayed methanol breakthrough from dry air on pre-dried carbon, but shortened the breakthrough time of both methanol and hexane under relative humidity (RH) of 30-85% on pre-humidified carbon. Aging also shortened the breakthrough time of the less volatile model compound 2-methoxyethanol, especially under RH of 60-85%. Aging significantly reduced the protection capacity against sarin at RH of 85%. The effects of aging on physisorption are attributed to enhanced hydrogen-bonding capability and strength of the interaction between water and adsorption sites on the carbon surface.

  19. Space Life Sciences Directorate's Position on the Physiological Effects of Exposing the Crewmemeber to Low-Voltage Electrical Hazards During Extravehicular Activity

    NASA Technical Reports Server (NTRS)

    Hamilton, Douglas; Kramer, Leonard; Mikatarian, Ron; Polk, James; Duncan, Michael; Koontz, Steven

    2010-01-01

    The models predict that, for low voltage exposures in the space suit, physiologically active current could be conducted across the crew member causing catastrophic hazards. Future work with Naval Health Research Center Detachment Directed Energy Bio-effects Laboratory is being proposed to analyze additional current paths across the human torso and upper limbs. These models may need to be verified with human studies.

  20. Hazardous'' terminology

    SciTech Connect

    Powers, J.

    1991-01-01

    A number of terms (e.g., hazardous chemicals,'' hazardous materials,'' hazardous waste,'' and similar nomenclature) refer to substances that are subject to regulation under one or more federal environmental laws. State laws and regulations also provide additional, similar, or identical terminology that may be confused with the federally defined terms. Many of these terms appear synonymous, and it easy to use them interchangeably. However, in a regulatory context, inappropriate use of narrowly defined terms can lead to confusion about the substances referred to, the statutory provisions that apply, and the regulatory requirements for compliance under the applicable federal statutes. This information Brief provides regulatory definitions, a brief discussion of compliance requirements, and references for the precise terminology that should be used when referring to hazardous'' substances regulated under federal environmental laws. A companion CERCLA Information Brief (EH-231-004/0191) addresses toxic'' nomenclature.

  1. Identifying Hazards

    EPA Pesticide Factsheets

    The federal government has established a system of labeling hazardous materials to help identify the type of material and threat posed. Summaries of information on over 300 chemicals are maintained in the Envirofacts Master Chemical Integrator.

  2. Coastal Hazards.

    ERIC Educational Resources Information Center

    Vandas, Steve

    1998-01-01

    Focuses on hurricanes and tsunamis and uses these topics to address other parts of the science curriculum. In addition to a discussion on beach erosion, a poster is provided that depicts these natural hazards that threaten coastlines. (DDR)

  3. Hazardous waste regulations: an interpretive guide

    SciTech Connect

    Mallow, A.

    1981-01-01

    Compliance with hazardous-waste laws has been made difficult by new, lengthy, and complicated Environmental Protection Agency regulations. This book analyzes and reorganizes the 150 pages of three-column regulations, clarifying all aspects of the requirements. Paralleling the related sections of the law (Subtitle C of the Resources Act), the book begins with an overview of the law and regulations and an identification and listing of hazardous wastes. There are guidelines for authorized state programs along with notification requirements for those in hazardous-waste activities. A checklist format, using five different scenarios offers a practical approach to analyzing the unique requirements for generators and transporters as well as owners and operators. 3 figures.

  4. Mental Arithmetic Activates Analogic Representations of Internally Generated Sums

    ERIC Educational Resources Information Center

    Kallai, Arava Y.; Schunn, Christian D.; Fiez, Julie A.

    2012-01-01

    The internal representation of numbers generated during calculation has received little attention. Much of the mathematics learning literature focuses on symbolic retrieval of math facts; in contrast, we critically test the hypothesis that internally generated numbers are represented analogically, using an approximate number system. In an fMRI…

  5. Activating Generative Learning in Organizations through Optimizing Relational Strategies

    ERIC Educational Resources Information Center

    Park, Mary Kay

    2010-01-01

    Using a grounded theory method, this dissertation seeks to discover how relationships impact organizational generative learning. An organization is a socially constructed reality and organizational learning is situated in the process of co-participation. To discover the link between relationships and generative learning this study considers the…

  6. Marine Hazards, a Result of Naval War Activities in the Pacific 1942-1945?

    NASA Astrophysics Data System (ADS)

    Bernaerts, A.

    2014-12-01

    The clash between the United States and Japan in the Pacific from December 1942 to August 1945 presumably caused marine geohazards exceeding significantly many submarine earthquakes, explosive volcanic eruptions and tsunamis. Most significantly the most pronounced shift in Pacific Decadal Oscillation (PDO) took place within the shortest period of time ever observed, and when the Allies navies approached Japan's coast line two years later, winter air temperatures (December to February 1944/45) fell to the lowest level ever observed. The Naval War in the Pacific from 1943 - 1945 was not only devastating to man and material, but also substantially altered the structure of the sea surface layer down to 100 meter and more, with a subsequent impact on air temperatures, and PDO balance across the Northern Pacific. Until now the question has received little attention although it is obvious that a global rising temperature trend prior the early 1940s turned into a decreasing mode during the time when huge naval war activities took place across the oceans in the Northern Hemisphere that eventually lasted for three decades until the mid-1970s While the impact of screw driven vessels since their invention in the 19th Century on the sea surface structure is difficult to assess, and no investigations have been made yet . The naval war in the Pacific from 1943 - 1945 could be regarded as a huge scale 'field experiment' on manmade marine geohazards due to the suddenness, the magnitude and the intensity, penetrating the ocean to considerable depths. Naval operations and available sea and climate data need to be identified, linked, evaluated and discussed. What kind of impact did the Pacific War have on climate? It seems due time to pay attention to this issue.

  7. Active faulting in Raghunandan Anticline, NE Bengal Basin, implications for future earthquake hazards

    NASA Astrophysics Data System (ADS)

    Ahsan, A.; Kali, E.; Coudurier Curveur, A.; van der Woerd, J.; Tapponnier, P.; Alam, A. K.; Ildefonso, S.; Banerjee, P.; Dorbath, C.

    2015-12-01

    The Bengal basin is situated in a complex tectonic zone where the Indian-Eurasian Plates and Indian-Burmese Plates are colliding. This region is known for some of the largest intra-continental seismic events of the last 500 years, the 1548 Bengal earthquake of magnitude M>8?, the 1762 Arakan earthquake of magnitude M>8?, the 1897 Shillong earthquakes of magnitude Ms 8.7, the 1918 Srimangal earthquake of magnitude Ms 7.6 and the 1950 Assam earthquake of magnitude Mw 8.6. The source faults of these events and whether these large earthquakes occurred on faults that reached the surface or reminded blind remain controversial. The Bengal basin still needs to be better understood in terms of active faulting and seismicity. The Eastern boundary of Bengal basin is marked by numerous NS trending folds of the Indo-Burma Ranges. We focused on the Raghunandan Anticline, NE Bengal basin, a broad, asymmetric, growing ramp anticline, steep west-facing front and bounded westwards by a steep tectonic scarp truncating gently east dipping Quaternary sandstone beds. The scarp morphology is suggestive of a still preserved co-seismic free face above a colluvial wedge. We carried out more than 20 topographic profiles to document the precise height and shape of this 12-15 m high scarp (above alluvial surface) and to survey a set of uplifted alluvial terraces located along the Shahapur River behind the scarp. The analysis of the topographic profiles around the Shajibazar area reveals the presence of 5 alluvial terraces hanging 3 m to 19 m above Shahapur River bed. T1 and T2 terraces are the best-preserved terraces on both sides of the Shahapur River. C14 and Be 10 ages allow to date the lowest abandonned terrace and to estimate the uplift rate of this area.

  8. Natural hazards science strategy

    USGS Publications Warehouse

    Holmes, Jr., Robert R.; Jones, Lucile M.; Eidenshink, Jeffery C.; Godt, Jonathan W.; Kirby, Stephen H.; Love, Jeffrey J.; Neal, Christina A.; Plant, Nathaniel G.; Plunkett, Michael L.; Weaver, Craig S.; Wein, Anne; Perry, Suzanne C.

    2012-01-01

    The mission of the U.S. Geological Survey (USGS) in natural hazards is to develop and apply hazard science to help protect the safety, security, and economic well-being of the Nation. The costs and consequences of natural hazards can be enormous, and each year more people and infrastructure are at risk. USGS scientific research - founded on detailed observations and improved understanding of the responsible physical processes - can help to understand and reduce natural hazard risks and to make and effectively communicate reliable statements about hazard characteristics, such as frequency, magnitude, extent, onset, consequences, and where possible, the time of future events. To accomplish its broad hazard mission, the USGS maintains an expert workforce of scientists and technicians in the earth sciences, hydrology, biology, geography, social and behavioral sciences, and other fields, and engages cooperatively with numerous agencies, research institutions, and organizations in the public and private sectors, across the Nation and around the world. The scientific expertise required to accomplish the USGS mission in natural hazards includes a wide range of disciplines that this report refers to, in aggregate, as hazard science. In October 2010, the Natural Hazards Science Strategy Planning Team (H-SSPT) was charged with developing a long-term (10-year) Science Strategy for the USGS mission in natural hazards. This report fulfills that charge, with a document hereinafter referred to as the Strategy, to provide scientific observations, analyses, and research that are critical for the Nation to become more resilient to natural hazards. Science provides the information that decisionmakers need to determine whether risk management activities are worthwhile. Moreover, as the agency with the perspective of geologic time, the USGS is uniquely positioned to extend the collective experience of society to prepare for events outside current memory. The USGS has critical statutory

  9. Natural hazards science strategy

    USGS Publications Warehouse

    Holmes, Jr., Robert R.; Jones, Lucile M.; Eidenshink, Jeffery C.; Godt, Jonathan W.; Kirby, Stephen H.; Love, Jeffrey J.; Neal, Christina A.; Plant, Nathaniel G.; Plunkett, Michael L.; Weaver, Craig S.; Wein, Anne; Perry, Suzanne C.

    2012-01-01

    The mission of the U.S. Geological Survey (USGS) in natural hazards is to develop and apply hazard science to help protect the safety, security, and economic well-being of the Nation. The costs and consequences of natural hazards can be enormous, and each year more people and infrastructure are at risk. USGS scientific research—founded on detailed observations and improved understanding of the responsible physical processes—can help to understand and reduce natural hazard risks and to make and effectively communicate reliable statements about hazard characteristics, such as frequency, magnitude, extent, onset, consequences, and where possible, the time of future events.To accomplish its broad hazard mission, the USGS maintains an expert workforce of scientists and technicians in the earth sciences, hydrology, biology, geography, social and behavioral sciences, and other fields, and engages cooperatively with numerous agencies, research institutions, and organizations in the public and private sectors, across the Nation and around the world. The scientific expertise required to accomplish the USGS mission in natural hazards includes a wide range of disciplines that this report refers to, in aggregate, as hazard science.In October 2010, the Natural Hazards Science Strategy Planning Team (H–SSPT) was charged with developing a long-term (10-year) Science Strategy for the USGS mission in natural hazards. This report fulfills that charge, with a document hereinafter referred to as the Strategy, to provide scientific observations, analyses, and research that are critical for the Nation to become more resilient to natural hazards. Science provides the information that decisionmakers need to determine whether risk management activities are worthwhile. Moreover, as the agency with the perspective of geologic time, the USGS is uniquely positioned to extend the collective experience of society to prepare for events outside current memory. The USGS has critical statutory

  10. Emotion at Work: A Contribution to Third-Generation Cultural-Historical Activity Theory

    ERIC Educational Resources Information Center

    Roth, Wolff-Michael

    2007-01-01

    Second-generation cultural-historical activity theory, which drew its inspiration from Leont'ev's work, constituted an advance over Vygotsky's first-generation theory by explicitly articulating the dialectical relation between individual and collective. As part of an effort to develop third-generation-historical activity theory, I propose in this…

  11. One-step green synthesis of non-hazardous dicarboxyl cellulose flocculant and its flocculation activity evaluation.

    PubMed

    Zhu, Hangcheng; Zhang, Yong; Yang, Xiaogang; Liu, Hongyi; Shao, Lan; Zhang, Xiumei; Yao, Juming

    2015-10-15

    The waste management of used flocculants is a thorny issue in the field of wastewater treatment. To natural cellulose based flocculants, utilization of hazardous cellulose solvent and simplification of synthetic procedure are the two urgent problems needing to be further improved. In this work, a series of natural dicarboxyl cellulose flocculants (DCCs) were one-step synthesized via Schiff-base route. The cellulose solvent (NaOH/Urea solution) was utilized during the synthesis process. The full-biodegradable flocculants avoid causing secondary pollution to environment. The chemical structure and solution property of the DCC products were characterized by FT-IR, (1)H NMR, (13)C NMR, TGA, FESEM, charge density and ζ-potential. Kaolin suspension and effluent from paper mill were selected to evaluate the flocculation activity of the DCCs. Their flocculation performance was compared with that of commercial cationic polyacrylamide and poly aluminium chloride flocculants. The positive results showed that the NaOH/Urea solvent effectively promoted the dialdehyde cellulose (DAC) conversion to DCC in the one-step synthesis reaction. The DCCs with the carboxylate content more than 1 mmol/g exhibited steady flocculation performance to kaolin suspension in the broad pH range from 4 to 10. Its flocculation capacity to the effluent from paper mill also showed excellent.

  12. A comparative investigation on adsorption performances of mesoporous activated carbon prepared from waste rubber tire and activated carbon for a hazardous azo dye--Acid Blue 113.

    PubMed

    Gupta, V K; Gupta, Bina; Rastogi, Arshi; Agarwal, Shilpi; Nayak, Arunima

    2011-02-15

    A mesoporous carbon developed from waste tire rubber, characterized by chemical analysis, FTIR, and SEM studies, was used as an adsorbent for the removal and recovery of a hazardous azo dye, Acid Blue 113. Surface area, porosity, and density were determined. The adsorption of the dye over the prepared adsorbent and a commercial activated carbon was achieved under different pH, adsorbate concentration, sieve size, adsorbent dosage, contact time and temperature conditions. Langmuir and Freundlich adsorption isotherm models were applied and thermodynamic parameters were calculated. Kinetic studies indicated that the adsorption process follow first order kinetics and particle diffusion mechanisms are operative. By percolating the dye solution through fixed-bed columns the bulk removal of the Acid Blue 113 was carried out and necessary parameters were determined to find out the percentage saturation of both the columns. Recovery of the dye was made by eluting 0.1 M NaOH through the column.

  13. California's potential volcanic hazards

    SciTech Connect

    Jorgenson, P. )

    1989-01-01

    Although volcanic eruptions have occurred infrequently in California during the last few thousand years, the potential danger to life and property from volcanoes in the state is great enough to be of concern, according to a recent U.S. Geological Survey (USGS) publication. The 17-page bulletin, Potential Hazards from Future Volcanic Eruptions in California, gives a brief history of volcanic activity in California during the past 100,000 years, descriptions of the types of volcanoes in the state, the types of potentially hazardous volcanic events that could occur, and hazard-zonation maps and tables depicting six areas of the state where volcanic eruptions might occur. The six areas and brief descriptions of their past volcanic history and potential for future volcanic hazards are briefly summarized here.

  14. Uncertainties in biological responses that influence hazard or risk approaches to the regulation of endocrine active substances

    EPA Science Inventory

    Endocrine Disrupting Chemicals (EDCs) may have delayed or transgenerational effects and display non-monotonic dose response relationships (NMDRs) that require careful consideration when determining environmental hazards. The case studies evaluated for the SETAC Pellston Workshop&...

  15. SETAC Pellston WorkshopTM: Environmental hazard and risk assessment approaches for endocrine-active chemicals (EHRA)

    EPA Science Inventory

    Suspected endocrine disrupting substances (EDS) are now being evaluated by several regulatory authorities. A debate is in progress about whether or not EDS can be adequately assessed by following the standard approach involving identification of intrinsic hazards, prediction of e...

  16. Flood- and Drought-Related Natural Hazards Activities of the U.S. Geological Survey in New England

    USGS Publications Warehouse

    Lombard, Pamela J.

    2016-03-23

    Tools for natural hazard assessment and mitigation • Light detection and ranging (lidar) remote sensing technology • StreamStats Web-based tool for streamflow statistics • Flood inundation mapper

  17. Can hazard risk be communicated through a virtual experience?

    PubMed

    Mitchell, J T

    1997-09-01

    Cyberspace, defined by William Gibson as a consensual hallucination, now refers to all computer-generated interactive environments. Virtual reality, one of a class of interactive cyberspaces, allows us to create and interact directly with objects not available in the everyday world. Despite successes in the entertainment and aviation industries, this technology has been called a 'solution in search of a problem'. The purpose of this commentary is to suggest such a problem: the inability to acquire experience with a hazard to motivate mitigation. Direct experience with a hazard has been demonstrated as a powerful incentive to adopt mitigation measures. While we lack the ability to summon hazard events at will in order to gain access to that experience, a virtual environment can provide an arena where potential victims are exposed to a hazard's effects. Immersion as an active participant within the hazard event through virtual reality may stimulate users to undertake mitigation steps that might otherwise remain undone. This paper details the possible direction in which virtual reality may be applied to hazards mitigation through a discussion of the technology, the role of hazard experience, the creation of a hazard stimulation and the issues constraining implementation.

  18. Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities

    PubMed Central

    Timofeev, Igor; Bazhenov, Maxim; Sejnowski, Terrence; Steriade, Mircea

    2002-01-01

    During paroxysmal neocortical oscillations, sudden depolarization leading to the next cycle occurs when the majority of cortical neurons are hyperpolarized. Both the Ca2+-dependent K+ currents (IK(Ca)) and disfacilitation play critical roles in the generation of hyperpolarizing potentials. In vivo experiments and computational models are used here to investigate whether the hyperpolarization-activated depolarizing current (Ih) in cortical neurons also contributes to the generation of paroxysmal onsets. Hyperpolarizing current pulses revealed a depolarizing sag in ≈20% of cortical neurons. Intracellular recordings from glial cells indirectly indicated an increase in extracellular potassium concentration ([K+]o) during paroxysmal activities, leading to a positive shift in the reversal potential of K+-mediated currents, including Ih. In the paroxysmal neocortex, ≈20% of neurons show repolarizing potentials originating from hyperpolarizations associated with depth-electroencephalogram positive waves of spike-wave complexes. The onset of these repolarizing potentials corresponds to maximal [K+]o as estimated from dual simultaneous impalements from neurons and glial cells. Computational models showed how, after the increased [K+]o, the interplay between Ih, IK(Ca), and a persistent Na+ current, INa(P), could organize paroxysmal oscillations at a frequency of 2–3 Hz. PMID:12089324

  19. Volcanic activity in the Acambay Graben: a < 25 Ka subplinian eruption from the Temascalcingo volcano and implications for volcanic hazard.

    NASA Astrophysics Data System (ADS)

    Pedrazzi, Dario; Aguirre Díaz, Gerardo; Sunyé Puchol, Ivan; Bartolini, Stefania; Geyer, Adelina

    2016-04-01

    The Trans-Mexican Volcanic Belt (TMVB) contains a large number of stratovolcanoes, some well-known, as Popocatepetl, Iztaccihuatl, Nevado de Toluca, or Colima and many others of more modest dimensions that are not well known but constitute the majority in the TMVB. Such volcanoes are, for example, Tequila, San Juan, Sangangüey, Cerro Culiacán, Cerro Grande, El Zamorano, La Joya, Palo Huerfano, Jocotitlán, Altamirano and Temascalcingo, among many others. The Temascalcingo volcano (TV) is an andesitic-dacitic stratovolcano located in the Trans-Mexican Volcanic Belt (TMVB) at the eastern part of the Acambay Graben (northwest portion of Estado de México). The TV is composed mainly by dacitic, porphyritic lavas, block and ash deposits and subordinate pumice fall deposits and ignimbrites (Roldán-Quintana et al., 2011). The volcanic structure includes a summit caldera that has a rectangular shape, 2.5×3.5 km, with the largest side oriented E-W, parallel to major normal faults affecting the edifice. The San Mateo Pumice eruption is one of the greatest paroxysmal episodes of this volcano with pumice deposits mainly exposed at the scarp of the Acambay-Tixmadeje fault and at the northern and northeastern flanks of TV. It overlies a paleosol dated at 25 Ka. A NE-trending dispersion was obtained from field data covering an area of at least 80 km2. These deposits overlie older lava flows and mud flows and are discontinuously covered and eroded by younger reworked deposits of Temascalcingo volcano. This event represents a highly explosive phase that generated a relatively thick and widespread pumice fallout deposit that may occur again in future eruptions. A similar eruption today would have a significantly impact in the region, overall due to the fact that there has been no systematic assessment of the volcanic hazard in any of the studies that have been conducted so far in the area. So, this is a pending and urgent subject that must be tackled without delay. Financed by

  20. NGNP SITE 2 HAZARDS ASSESSMENT

    SciTech Connect

    Wayne Moe

    2011-10-01

    The Next Generation Nuclear Plant (NGNP) Project initiated at Idaho National Laboratory (INL) by the U.S. Department of Energy pursuant to the 2005 Energy Policy Act, is based on research and development activities supported by the Generation IV Nuclear Energy Systems Initiative. The principal objective of the NGNP Project is to support commercialization of the high temperature gas-cooled reactor (HTGR) technology. The HTGR is a helium-cooled and graphite-moderated reactor that can operate at temperatures much higher than those of conventional light water reactor (LWR) technologies. Accordingly, it can be applied in many industrial applications as a substitute for burning fossil fuels, such as natural gas, to generate process heat in addition to producing electricity, which is the principal application of current LWRs. Nuclear energy in the form of LWRs has been used in the U.S. and internationally principally for the generation of electricity. However, because the HTGR operates at higher temperatures than LWRs, it can be used to displace the use of fossil fuels in many industrial applications. It also provides a carbon emission-free energy supply. For example, the energy needs for the recovery and refining of petroleum, for the petrochemical industry and for production of transportation fuels and feedstocks using coal conversion processes require process heat provided at temperatures approaching 800 C. This temperature range is readily achieved by the HTGR technology. This report summarizes a site assessment authorized by INL under the NGNP Project to determine hazards and potential challenges that site owners and HTGR designers need to be aware of when developing the HTGR design for co-location at industrial facilities, and to evaluate the site for suitability considering certain site characteristics. The objectives of the NGNP site hazard assessments are to do an initial screening of representative sites in order to identify potential challenges and restraints

  1. Does changing from a first generation antipsychotic (perphenazin) to a second generation antipsychotic (risperidone) alter brain activation and motor activity? A case report

    PubMed Central

    2013-01-01

    Background In patients with schizophrenia, altered brain activation and motor activity levels are central features, reflecting cognitive impairments and negative symptoms, respectively. Newer studies using nonlinear methods have addressed the severe disturbances in neurocognitive functioning that is regarded as one of the core features of schizophrenia. Our aim was to compare brain activation and motor activity in a patient during pharmacological treatment that was switched from a first- to a second-generation antipsychotic drug. We hypothesised that this change of medication would increase level of responding in both measures. Case presentation We present the case of a 53-year-old male with onset of severe mental illness in adolescence, ICD-10 diagnosed as schizophrenia of paranoid type, chronic form. We compared brain activation and motor activity in this patient during pharmacological treatment with a first-generation (perphenazin), and later switched to a second-generation (risperidone) antipsychotic drug. We used functional magnetic resonance imaging (fMRI) to measure brain activation and wrist worn actigraphy to measure motor activity. Conclusion Our study showed that brain activation decreased in areas critical for cognitive functioning in this patient, when changing from a first to a second generation antipsychotic drug. However the mean motor activity level was unchanged, although risperidone reduced variability, particularly short-term variability from minute to minute. Compared to the results from previous studies, the present findings indicate that changing to a second-generation antipsychotic alters variability measures towards that seen in a control group, but with reduced brain activation, which was an unexpected finding. PMID:23648137

  2. Biogeosystem technique as a method to overcome the Biological and Environmental Hazards of modern Agricultural, Irrigational and Technological Activities

    NASA Astrophysics Data System (ADS)

    Kalinitchenko, Valery; Batukaev, Abdulmalik; Zinchenko, Vladimir; Zarmaev, Ali; Magomadov, Ali; Chernenko, Vladimir; Startsev, Viktor; Bakoev, Serojdin; Dikaev, Zaurbek

    2014-05-01

    Modern challenge for humanity is to replace the paradigm of nature use and overcome environmental hazards of agronomy, irrigation, industry, and other human activities in biosphere. It is utterly reasonable to stop dividing biosphere on shares - the human habitat and the environment. In the 21st century it is an outdated anthropocentrism. Contradicting himself to biosphere Humankind has the problems. The new paradigm of biosphere control by methods of Biogeosystem technique is on agenda of Humankind. Key directions of Biogeosystem technique. Tillage. Single rotary milling 20…30-50…60 sm soil layer optimizes the evolution and environment of soil, creates a favorable conditions for the rhizosphere, increases the biological productivity of biosphere by 30-50% compared to the standard agricultural practices for the period up to 40 years. Recycle material. Recycling of mineral and organic substances in soil layer of 20…30-50…60 sm in rotary milling soil processing provides wastes clean return to biosphere. Direct intrasoil substances synthesis. Environmentally friendly robot wasteless nanotechnology provides direct substances synthesis, including fertilizers, inside the soil. It eliminates the prerequisites of the wastes formation under standard industrial technologies. Selective substance's extraction from soil. Electrochemical robotic nanotechnology provides selective substances extraction from soil. The technology provides recovery, collection and subsequent safe industrial use of extracted substances out of landscape. Saving fresh water. An important task is to save fresh water in biosphere. Irrigation spends water 4-5 times more of biological requirements of plants, leads to degradation of soil and landscape. The intrasoil pulse continuous-discrete paradigm of irrigation is proposed. It provides the soil and landscape conservation, increases the biological productivity, save the fresh water up to 10-20 times. The subsurface soil rotary processing and

  3. An assessment of hazards caused by electromagnetic interaction on humans present near short-wave physiotherapeutic devices of various types including hazards for users of electronic active implantable medical devices (AIMD).

    PubMed

    Karpowicz, Jolanta; Gryz, Krzysztof

    2013-01-01

    Leakage of electromagnetic fields (EMF) from short-wave radiofrequency physiotherapeutic diathermies (SWDs) may cause health and safety hazards affecting unintentionally exposed workers (W) or general public (GP) members (assisting patient exposed during treatment or presenting there for other reasons). Increasing use of electronic active implantable medical devices (AIMDs), by patients, attendants, and workers, needs attention because dysfunctions of these devices may be caused by electromagnetic interactions. EMF emitted by 12 SWDs (with capacitive or inductive applicators) were assessed following international guidelines on protection against EMF exposure (International Commission on Nonionizing Radiation Protection for GP and W, new European directive 2013/35/EU for W, European Recommendation for GP, and European Standard EN 50527-1 for AIMD users). Direct EMF hazards for humans near inductive applicators were identified at a distance not exceeding 45 cm for W or 62 cm for GP, but for AIMD users up to 90 cm (twice longer than that for W and 50% longer than that for GP because EMF is pulsed modulated). Near capacitive applicators emitting continuous wave, the corresponding distances were: 120 cm for W or 150 cm for both-GP or AIMD users. This assessment does not cover patients who undergo SWD treatment (but it is usually recommended for AIMD users to be careful with EMF treatment).

  4. Hazard maps of Colima volcano, Mexico

    NASA Astrophysics Data System (ADS)

    Suarez-Plascencia, C.; Nunez-Cornu, F. J.; Escudero Ayala, C. R.

    2011-12-01

    Colima volcano, also known as Volcan de Fuego (19° 30.696 N, 103° 37.026 W), is located on the border between the states of Jalisco and Colima and is the most active volcano in Mexico. Began its current eruptive process in February 1991, in February 10, 1999 the biggest explosion since 1913 occurred at the summit dome. The activity during the 2001-2005 period was the most intense, but did not exceed VEI 3. The activity resulted in the formation of domes and their destruction after explosive events. The explosions originated eruptive columns, reaching attitudes between 4,500 and 9,000 m.a.s.l., further pyroclastic flows reaching distances up to 3.5 km from the crater. During the explosive events ash emissions were generated in all directions reaching distances up to 100 km, slightly affected nearby villages as Tuxpan, Tonila, Zapotlán, Cuauhtemoc, Comala, Zapotitlan de Vadillo and Toliman. During the 2005 this volcano has had an intense effusive-explosive activity, similar to the one that took place during the period of 1890 through 1900. Intense pre-plinian eruption in January 20, 1913, generated little economic losses in the lower parts of the volcano due to low population density and low socio-economic activities at the time. Shows the updating of the volcanic hazard maps published in 2001, where we identify whit SPOT satellite imagery and Google Earth, change in the land use on the slope of volcano, the expansion of the agricultural frontier on the east and southeast sides of the Colima volcano, the population inhabiting the area is approximately 517,000 people, and growing at an annual rate of 4.77%, also the region that has shown an increased in the vulnerability for the development of economic activities, supported by the construction of highways, natural gas pipelines and electrical infrastructure that connect to the Port of Manzanillo to Guadalajara city. The update the hazard maps are: a) Exclusion areas and moderate hazard for explosive events

  5. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  6. Biological activity of photoproducts of merocyanine 540 generated by laser-light activation

    NASA Astrophysics Data System (ADS)

    Gulliya, Kirpal S.; Chanh, Tran C.; Pervaiz, Shazib; Harriman, Anthony; Matthews, James Lester

    1992-08-01

    Controlled exposure of photoactive compounds to light prior to their use in biological targets results in the formation of heretofore unknown photoproducts. This process of photoproduct generation, termed "preactivation," renders the photactive compound capable of systemic use without further dependence on light. Preactivation of mercyanin 540 (MC540) and several other photoactive compounds is achievable by exposure to CW and pulse laser radiation. The singlet oxygen generated at excited states attacks the dye molucule itself, resulting in the formation of biologically active photoproducts. For preactivated MC540 (photoproducts of MC540) generated by exposure to argon laser light (514 nm) and light from free-electron laser, we have demonstrated its effectiveness in selective killing of certain types of cultured tumor cells as well as human immunodeficiency virus type 1 (HIV-1) with very low, if any, damage to normal cells and tisues. For example, approximately 90% of the Burkitt's lymphoma Daudi cells and HL-60 leukemic cells are killed by preactivated MC540 at a concentration of 120 μg/ml. A two-hour treatment of cultured cells with buthionine sulfoxamine followed by the treatement with preactivated MC540 reults in 99.99% inhibition of clonogenic tumor stem cell growth. We also have demonstrated that preactivated MC540 is very effective in killing cell-free and cell-associated HIV-1. It also is very effective in killing HIV-1 and simian immunodeficiency virus (SIV) in virus-infected blood in vitro as determined by reverse transcriptase, P24, P17, core antigen expression and synctium formation. Treatment of HIV-1 with preactivated MC540 renders the treated HIV-1 incapable of binding to CD4 target molecules on T cells as determined by immunofluorescence and radioimmunoprecipitation assays. In vivo toxicology studies show that preactivated MC540 is very well tolerated and does not produce any signs of adverse reaction at the therapeutic doses, as determined by

  7. Sensing network for electromagnetic fields generated by seismic activities

    NASA Astrophysics Data System (ADS)

    Gershenzon, Naum I.; Bambakidis, Gust; Ternovskiy, Igor V.

    2014-06-01

    The sensors network is becoming prolific and play now increasingly more important role in acquiring and processing information. Cyber-Physical Systems are focusing on investigation of integrated systems that includes sensing, networking, and computations. The physics of the seismic measurement and electromagnetic field measurement requires special consideration how to design electromagnetic field measurement networks for both research and detection earthquakes and explosions along with the seismic measurement networks. In addition, the electromagnetic sensor network itself could be designed and deployed, as a research tool with great deal of flexibility, the placement of the measuring nodes must be design based on systematic analysis of the seismic-electromagnetic interaction. In this article, we review the observations of the co-seismic electromagnetic field generated by earthquakes and man-made sources such as vibrations and explosions. The theoretical investigation allows the distribution of sensor nodes to be optimized and could be used to support existing geological networks. The placement of sensor nodes have to be determined based on physics of electromagnetic field distribution above the ground level. The results of theoretical investigations of seismo-electromagnetic phenomena are considered in Section I. First, we compare the relative contribution of various types of mechano-electromagnetic mechanisms and then analyze in detail the calculation of electromagnetic fields generated by piezomagnetic and electrokinetic effects.

  8. Probabilistic Tsunami Hazard Assessment - Application to the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Sorensen, M. B.; Spada, M.; Babeyko, A.; Wiemer, S.; Grünthal, G.

    2009-12-01

    Following several large tsunami events around the world in the recent years, the tsunami hazard is becoming an increasing concern. The traditional way of assessing tsunami hazard has been through deterministic scenario calculations which provide the expected wave heights due to a given tsunami source, usually a worst-case scenario. For quantitative hazard and risk assessment, however, it is necessary to move towards a probabilistic framework. In this study we focus on earthquake generated tsunamis and present a scheme for probabilistic tsunami hazard assessment (PTHA). Our PTHA methodology is based on the use of Monte-Carlo simulations and follows probabilistic seismic hazard assessment methodologies closely. The PTHA is performed in four steps. First, earthquake and tsunami catalogues are analyzed in order to define a number of potential tsunami sources in the study area. For each of these sources, activity rates, maximum earthquake magnitude and uncertainties are assigned. Following, a synthetic earthquake catalogue is established, based on the information about the sources. The third step is to calculate multiple synthetic tsunami scenarios for all potentially tsunamigenic earthquakes in the synthetic catalogue. The tsunami scenarios are then combined at the fourth step to generate hazard curves and maps. We implement the PTHA methodology in the Mediterranean Sea, where numerous tsunami events have been reported in history. We derive a 100000 year-long catalog of potentially tsunamigenic earthquakes and calculate tsunami propagation scenarios for ca. 85000 M6.5+ earthquakes from the synthetic catalog. Results show that the highest tsunami hazard is attributed to the Eastern Mediterranean region, but that also the Western Mediterranean can experience significant tsunami waves for long return periods. Hazard maps will be presented for a range of probability levels together with hazard curves for selected critical locations.

  9. Tsunami Forecast Technology for Asteroid Impact Hazard Assessment

    NASA Astrophysics Data System (ADS)

    Titov, V. V.; Moore, C. W.

    2015-12-01

    Over 75% of all historically documented tsunamis have been generated by earthquakes. As the result, all existing Tsunami Warning and Forecast systems focus almost exclusively on detecting, warning and forecasting earthquake-generated tsunamis.The sequence of devastating tsunamis across the globe over the past 10 years has significantly heightened awareness and preparation activities associated with these high-impact events. Since the catastrophic 2004 Sumatra tsunami, NOAA has invested significant efforts in modernizing the U.S. tsunami warning system. Recent developments in tsunami modeling capability, inundation forecasting, sensing networks, dissemination capability and local preparation and mitigation activities have gone a long way toward enhancing tsunami resilience within the United States. The remaining quarter of the tsunami hazard problem is related to other mechanisms of tsunami generation, that may not have received adequate attention. Among those tsunami sources, the asteroid impact may be the most exotic, but possible one of the most devastating tsunami generation mechanisms. Tsunami forecast capabilities that have been developed for the tsunami warning system can be used to explore both, hazard assessment and the forecast of a tsunami generated by the asteroid impact. Existing tsunami flooding forecast technology allows for forecast for non-seismically generated tsunamis (asteroid impact, meteo-generated tsunamis, landslides, etc.), given an adequate data for the tsunami source parameters. Problems and opportunities for forecast of tsunamis from asteroid impact will be discussed. Preliminary results of impact-generated tsunami analysis for forecast and hazard assessment will be presented.

  10. Educating for Political Activity: A Younger Generational Response

    ERIC Educational Resources Information Center

    Mac an Ghaill, Mairtin

    2010-01-01

    This paper is a response to Professor Chitty's "Educational Review" Guest Lecture article, "Educating for political activity". I address the three sections of his paper: a global and national-based politics of war, corporate manipulation and parliamentary scandals. This provides a basis to draw upon empirical material from a…

  11. Morphological Transformation and Force Generation of Active Cytoskeletal Networks

    PubMed Central

    Maruri, Daniel; Kamm, Roger D.

    2017-01-01

    Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation. PMID:28114384

  12. Scientific and legal perspectives on science generated for regulatory activities.

    PubMed

    Henry, Carol J; Conrad, James W

    2008-01-01

    This article originated from a conference that asked "Should scientific work conducted for purposes of advocacy before regulatory agencies or courts be judged by the same standards as science conducted for other purposes?" In the article, which focuses on the regulatory advocacy context, we argue that it can be and should be. First, we describe a set of standards and practices currently being used to judge the quality of scientific research and testing and explain how these standards and practices assist in judging the quality of research and testing regardless of why the work was conducted. These standards and practices include the federal Information Quality Act, federal Good Laboratory Practice standards, peer review, disclosure of funding sources, and transparency in research policies. The more that scientific information meets these standards and practices, the more likely it is to be of high quality, reliable, reproducible, and credible. We then explore legal issues that may be implicated in any effort to create special rules for science conducted specifically for a regulatory proceeding. Federal administrative law does not provide a basis for treating information in a given proceeding differently depending on its source or the reason for which it was generated. To the contrary, this law positively assures that interested persons have the right to offer their technical expertise toward the solution of regulatory problems. Any proposal to subject scientific information generated for the purpose of a regulatory proceeding to more demanding standards than other scientific information considered in that proceeding would clash with this law and would face significant administrative complexities. In a closely related example, the U.S. Environmental Protection Agency considered but abandoned a program to implement standards aimed at "external" information.

  13. Hazard identification for contaminants.

    PubMed

    Iscan, Mümtaz

    2004-12-15

    In recent years, the recognition of generation of large quantities of toxicants and their by-products due to the industrial and/or cultural activities and transport and their persistence in the environment and biological activities brings out the necessity and importance of their assessment of risk they pose to the ecosystems (e.g. aquatic environment-coastal waters, rivers, lakes and ground water). Indeed, understanding the impacts of contaminants on the environment, including the organisms which live in it, is rather complicated. Nevertheless, the need for protection of the scarce natural resources in the environment and wiser use of them brings the necessity and importance of focusing more attention to the issue. Accordingly the process of ecological risk assessment (ERA) has evolved rapidly since the Environmental Protection Agency (EPA) issued a framework for ecological risk assessment in 1992. The ecological risk assessment involves three stages in a continuous process: (1) problem formulation (problem identification-hazard identification), (2) the analysis of exposure and effects and (3) risk characterisation. Risk management follows the risk characterisation. Of these stages, problem identification is the most critical one which establishes the direction and scope of the ecological risk assessment. The stage involves identifying the actual environmental value(s) to be protected (assessment endpoints) and selecting ways in which these can be measured and evaluated (measurement endpoints). The accuracy of the risk estimation is largely based on the availability of the key information about the contaminant characteristics, ecosystem at risk and ecological effects and the less uncertainty associated with them. The key information required during this phase of the risk assessment process are as follows: (a) potential/actual contaminant of concern, (b) source of contaminant; current and historic use, (c) mode of action of the contaminant, (d) contaminant

  14. 10 CFR 851.21 - Hazard identification and assessment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... using of accredited and certified laboratories; (3) Record observations, testing and monitoring results... hazards; (6) Perform routine job activity-level hazard analyses; (7) Review site safety and...

  15. Geothermal hazards - Mercury emission

    NASA Technical Reports Server (NTRS)

    Siegel, S. M.; Siegel, B. Z.

    1975-01-01

    Enthusiasm for intensified geothermal exploration may induce many participants to overlook a long-term potential toxicity hazard possibly associated with the tapping of magmatic steam. The association of high atmospheric Hg levels with geothermal activity has been established both in Hawaii and Iceland, and it has been shown that mercury can be introduced into the atmosphere from fumaroles, hot springs, and magmatic sources. These arguments, extended to thallium, selenium, and other hazardous elements, underscore the need for environmental monitoring in conjunction with the delivery of magmatic steam to the surface.

  16. Probabilistic Analysis of Activation Volumes Generated During Deep Brain Stimulation

    PubMed Central

    Butson, Christopher R.; Cooper, Scott E.; Henderson, Jaimie M.; Wolgamuth, Barbara; McIntyre, Cameron C.

    2010-01-01

    Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson’s disease (PD) and shows great promise for the treatment of several other disorders. However, while the clinical analysis of DBS has received great attention, a relative paucity of quantitative techniques exists to define the optimal surgical target and most effective stimulation protocol for a given disorder. In this study we describe a methodology that represents an evolutionary addition to the concept of a probabilistic brain atlas, which we call a probabilistic stimulation atlas (PSA). We outline steps to combine quantitative clinical outcome measures with advanced computational models of DBS to identify regions where stimulation-induced activation could provide the best therapeutic improvement on a per-symptom basis. While this methodology is relevant to any form of DBS, we present example results from subthalamic nucleus (STN) DBS for PD. We constructed patient-specific computer models of the volume of tissue activated (VTA) for 163 different stimulation parameter settings which were tested in six patients. We then assigned clinical outcome scores to each VTA and compiled all of the VTAs into a PSA to identify stimulation-induced activation targets that maximized therapeutic response with minimal side effects. The results suggest that selection of both electrode placement and clinical stimulation parameter settings could be tailored to the patient’s primary symptoms using patient-specific models and PSAs. PMID:20974269

  17. Probabilistic analysis of activation volumes generated during deep brain stimulation.

    PubMed

    Butson, Christopher R; Cooper, Scott E; Henderson, Jaimie M; Wolgamuth, Barbara; McIntyre, Cameron C

    2011-02-01

    Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson's disease (PD) and shows great promise for the treatment of several other disorders. However, while the clinical analysis of DBS has received great attention, a relative paucity of quantitative techniques exists to define the optimal surgical target and most effective stimulation protocol for a given disorder. In this study we describe a methodology that represents an evolutionary addition to the concept of a probabilistic brain atlas, which we call a probabilistic stimulation atlas (PSA). We outline steps to combine quantitative clinical outcome measures with advanced computational models of DBS to identify regions where stimulation-induced activation could provide the best therapeutic improvement on a per-symptom basis. While this methodology is relevant to any form of DBS, we present example results from subthalamic nucleus (STN) DBS for PD. We constructed patient-specific computer models of the volume of tissue activated (VTA) for 163 different stimulation parameter settings which were tested in six patients. We then assigned clinical outcome scores to each VTA and compiled all of the VTAs into a PSA to identify stimulation-induced activation targets that maximized therapeutic response with minimal side effects. The results suggest that selection of both electrode placement and clinical stimulation parameter settings could be tailored to the patient's primary symptoms using patient-specific models and PSAs.

  18. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.

    PubMed

    Thomas, Christopher P; Morgan, Lloyd T; Maskrey, Benjamin H; Murphy, Robert C; Kühn, Hartmut; Hazen, Stanley L; Goodall, Alison H; Hamali, Hassan A; Collins, Peter W; O'Donnell, Valerie B

    2010-03-05

    Here, a group of specific lipids, comprising phosphatidylethanolamine (PE)- or phosphatidylcholine (PC)-esterified 12S-hydroxyeicosatetraenoic acid (12S-HETE), generated by 12-lipoxygenase was identified and characterized. 12S-HETE-PE/PCs were formed within 5 min of activation by thrombin, ionophore, or collagen. Esterified HETE levels generated in response to thrombin were 5.85 +/- 1.42 (PE) or 18.35 +/- 4.61 (PC), whereas free was 65.5 +/- 17.6 ng/4 x 10(7) cells (n = 5 separate donors, mean +/- S.E.). Their generation was stimulated by triggering protease-activated receptors-1 and -4 and signaling via Ca(2+) mobilization secretory phospholipase A2, platelet-activating factor-acetylhydrolase, src tyrosine kinases, and protein kinase C. Stable isotope labeling showed that they form predominantly by esterification that occurs on the same time scale as free acid generation. Unlike free 12S-HETE that is secreted, esterified HETEs remain cell-associated, with HETE-PEs migrating to the outside of the plasma membrane. 12-Lipoxygenase inhibition attenuated externalization of native PE and phosphatidylserine and HETE-PEs. Platelets from a patient with the bleeding disorder, Scott syndrome, did not externalize HETE-PEs, and liposomes supplemented with HETE-PC dose-dependently enhanced tissue factor-dependent thrombin generation in vitro. This suggests a role for these novel lipids in promoting coagulation. Thus, oxidized phospholipids form by receptor/agonist mechanisms, not merely as an undesirable consequence of vascular and inflammatory disease.

  19. Impact-generated Hydrothermal Activity at the Chicxulub Crater

    NASA Astrophysics Data System (ADS)

    Kring, D. A.; Zurcher, L.; Abramov, O.

    2007-05-01

    Borehole samples recovered from PEMEX exploration boreholes and an ICDP scientific borehole indicate the Chicxulub impact event generated hydrothermal alteration throughout a large volume of the Maya Block beneath the crater floor and extending across the bulk of the ~180 km diameter crater. The first indications of hydrothermal alteration were observed in the crater discovery samples from the Yucatan-6 borehole and manifest itself in the form of anhydrite and quartz veins. Continuous core from the Yaxcopoil-1 borehole reveal a more complex and temporally extensive alteration sequence: following a brief period at high temperatures, impact- melt-bearing polymict breccias and a thin, underlying unit of impact melt were subjected to metasomatism, producing alkali feldspar, sphene, apatite, and magnetite. As the system continued to cool, smectite-series phyllosilicates appeared. A saline solution was involved. Stable isotopes suggest the fluid was dominated by a basinal brine created mostly from existing groundwater of the Yucatan Peninsula, although contributions from down-welling water also occurred in some parts of the system. Numerical modeling of the hydrothermal system suggests circulation occurred for 1.5 to 2.3 Myr, depending on the permeability of the system. Our understanding of the hydrothermal system, however, is still crude. Additional core recovery projects, particularly into the central melt sheet, are needed to better evaluate the extent and duration of hydrothermal alteration.

  20. Deterministic generation of remote entanglement with active quantum feedback

    SciTech Connect

    Martin, Leigh; Motzoi, Felix; Li, Hanhan; Sarovar, Mohan; Whaley, K. Birgitta

    2015-12-10

    We develop and study protocols for deterministic remote entanglement generation using quantum feedback, without relying on an entangling Hamiltonian. In order to formulate the most effective experimentally feasible protocol, we introduce the notion of average-sense locally optimal feedback protocols, which do not require real-time quantum state estimation, a difficult component of real-time quantum feedback control. We use this notion of optimality to construct two protocols that can deterministically create maximal entanglement: a semiclassical feedback protocol for low-efficiency measurements and a quantum feedback protocol for high-efficiency measurements. The latter reduces to direct feedback in the continuous-time limit, whose dynamics can be modeled by a Wiseman-Milburn feedback master equation, which yields an analytic solution in the limit of unit measurement efficiency. Our formalism can smoothly interpolate between continuous-time and discrete-time descriptions of feedback dynamics and we exploit this feature to derive a superior hybrid protocol for arbitrary nonunit measurement efficiency that switches between quantum and semiclassical protocols. Lastly, we show using simulations incorporating experimental imperfections that deterministic entanglement of remote superconducting qubits may be achieved with current technology using the continuous-time feedback protocol alone.

  1. Deterministic generation of remote entanglement with active quantum feedback

    DOE PAGES

    Martin, Leigh; Motzoi, Felix; Li, Hanhan; ...

    2015-12-10

    We develop and study protocols for deterministic remote entanglement generation using quantum feedback, without relying on an entangling Hamiltonian. In order to formulate the most effective experimentally feasible protocol, we introduce the notion of average-sense locally optimal feedback protocols, which do not require real-time quantum state estimation, a difficult component of real-time quantum feedback control. We use this notion of optimality to construct two protocols that can deterministically create maximal entanglement: a semiclassical feedback protocol for low-efficiency measurements and a quantum feedback protocol for high-efficiency measurements. The latter reduces to direct feedback in the continuous-time limit, whose dynamics can bemore » modeled by a Wiseman-Milburn feedback master equation, which yields an analytic solution in the limit of unit measurement efficiency. Our formalism can smoothly interpolate between continuous-time and discrete-time descriptions of feedback dynamics and we exploit this feature to derive a superior hybrid protocol for arbitrary nonunit measurement efficiency that switches between quantum and semiclassical protocols. Lastly, we show using simulations incorporating experimental imperfections that deterministic entanglement of remote superconducting qubits may be achieved with current technology using the continuous-time feedback protocol alone.« less

  2. Hazardous fluid leak detector

    DOEpatents

    Gray, Harold E.; McLaurin, Felder M.; Ortiz, Monico; Huth, William A.

    1996-01-01

    A device or system for monitoring for the presence of leaks from a hazardous fluid is disclosed which uses two electrodes immersed in deionized water. A gas is passed through an enclosed space in which a hazardous fluid is contained. Any fumes, vapors, etc. escaping from the containment of the hazardous fluid in the enclosed space are entrained in the gas passing through the enclosed space and transported to a closed vessel containing deionized water and two electrodes partially immersed in the deionized water. The electrodes are connected in series with a power source and a signal, whereby when a sufficient number of ions enter the water from the gas being bubbled through it (indicative of a leak), the water will begin to conduct, thereby allowing current to flow through the water from one electrode to the other electrode to complete the circuit and activate the signal.

  3. Integrating GIS with AHP and Fuzzy Logic to generate hand, foot and mouth disease hazard zonation (HFMD-HZ) model in Thailand

    NASA Astrophysics Data System (ADS)

    Samphutthanon, R.; Tripathi, N. K.; Ninsawat, S.; Duboz, R.

    2014-12-01

    The main objective of this research was the development of an HFMD hazard zonation (HFMD-HZ) model by applying AHP and Fuzzy Logic AHP methodologies for weighting each spatial factor such as disease incidence, socio-economic and physical factors. The outputs of AHP and FAHP were input into a Geographic Information Systems (GIS) process for spatial analysis. 14 criteria were selected for analysis as important factors: disease incidence over 10 years from 2003 to 2012, population density, road density, land use and physical features. The results showed a consistency ratio (CR) value for these main criteria of 0.075427 for AHP, the CR for FAHP results was 0.092436. As both remained below the threshold of 0.1, the CR value were acceptable. After linking to actual geospatial data (disease incidence 2013) through spatial analysis by GIS for validation, the results of the FAHP approach were found to match more accurately than those of the AHP approach. The zones with the highest hazard of HFMD outbreaks were located in two main areas in central Muang Chiang Mai district including suburbs and Muang Chiang Rai district including the vicinity. The produced hazardous maps may be useful for organizing HFMD protection plans.

  4. A~probabilistic tsunami hazard assessment for Indonesia

    NASA Astrophysics Data System (ADS)

    Horspool, N.; Pranantyo, I.; Griffin, J.; Latief, H.; Natawidjaja, D. H.; Kongko, W.; Cipta, A.; Bustaman, B.; Anugrah, S. D.; Thio, H. K.

    2014-05-01

    Probabilistic hazard assessments are a fundamental tool for assessing the threats posed by hazards to communities and are important for underpinning evidence based decision making on risk mitigation activities. Indonesia has been the focus of intense tsunami risk mitigation efforts following the 2004 Indian Ocean Tsunami, but this has been largely concentrated on the Sunda Arc, with little attention to other tsunami prone areas of the country such as eastern Indonesia. We present the first nationally consistent Probabilistic Tsunami Hazard Assessment (PTHA) for Indonesia. This assessment produces time independent forecasts of tsunami hazard at the coast from tsunami generated by local, regional and distant earthquake sources. The methodology is based on the established monte-carlo approach to probabilistic seismic hazard assessment (PSHA) and has been adapted to tsunami. We account for sources of epistemic and aleatory uncertainty in the analysis through the use of logic trees and through sampling probability density functions. For short return periods (100 years) the highest tsunami hazard is the west coast of Sumatra, south coast of Java and the north coast of Papua. For longer return periods (500-2500 years), the tsunami hazard is highest along the Sunda Arc, reflecting larger maximum magnitudes along the Sunda Arc. The annual probability of experiencing a tsunami with a height at the coast of > 0.5 m is greater than 10% for Sumatra, Java, the Sunda Islands (Bali, Lombok, Flores, Sumba) and north Papua. The annual probability of experiencing a tsunami with a height of >3.0 m, which would cause significant inundation and fatalities, is 1-10% in Sumatra, Java, Bali, Lombok and north Papua, and 0.1-1% for north Sulawesi, Seram and Flores. The results of this national scale hazard assessment provide evidence for disaster managers to prioritise regions for risk mitigation activities and/or more detailed hazard or risk assessment.

  5. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

    PubMed Central

    Horlbeck, Max A; Gilbert, Luke A; Villalta, Jacqueline E; Adamson, Britt; Pak, Ryan A; Chen, Yuwen; Fields, Alexander P; Park, Chong Yon; Corn, Jacob E; Kampmann, Martin; Weissman, Jonathan S

    2016-01-01

    We recently found that nucleosomes directly block access of CRISPR/Cas9 to DNA (Horlbeck et al., 2016). Here, we build on this observation with a comprehensive algorithm that incorporates chromatin, position, and sequence features to accurately predict highly effective single guide RNAs (sgRNAs) for targeting nuclease-dead Cas9-mediated transcriptional repression (CRISPRi) and activation (CRISPRa). We use this algorithm to design next-generation genome-scale CRISPRi and CRISPRa libraries targeting human and mouse genomes. A CRISPRi screen for essential genes in K562 cells demonstrates that the large majority of sgRNAs are highly active. We also find CRISPRi does not exhibit any detectable non-specific toxicity recently observed with CRISPR nuclease approaches. Precision-recall analysis shows that we detect over 90% of essential genes with minimal false positives using a compact 5 sgRNA/gene library. Our results establish CRISPRi and CRISPRa as premier tools for loss- or gain-of-function studies and provide a general strategy for identifying Cas9 target sites. DOI: http://dx.doi.org/10.7554/eLife.19760.001 PMID:27661255

  6. Generation and remote delivery of plasma activated species

    NASA Astrophysics Data System (ADS)

    Maguire, Paul; Mahony, Charles; Kelsey, Colin; Rutherford, David; Mariotti, Davide; Macias-Montero, Manuel; Perez-Martin, Fatima; Diver, Declan

    2016-09-01

    Plasma interactions with microdroplets offer new opportunities to deliver active chemical agents and nanoparticles to remote substrates downstream with many potential applications from cancer theranostics and wound healing in biomedicine, gentle food decontamination and seed germination in plasma agriculture to catalyst production and photonic structures fabrication, among others. We demonstrate plasma-liquid based pristine nanomaterials synthesis in flight and subsequent delivery up to 120mm from the atmospheric pressure plasma source. Monosized and non-aggregating metal nanoparticles are formed in the rf plasma in less than 100us, representing an increase in precursor reduction rate that is many (>4) orders of magnitude faster than that observed with standard colloidal chemistry or via high energy radiolytic techniques. Also the collection and purification limitations of the latter are avoided. Plasma activated liquid including OH radicals and H2O2 are transported over 120mm and have demonstrated high efficacy bacterial decontamination. These results will be compared with charge species and radical transport from the rf plasma without microdroplets. Reaction models based on high solvated surface electron concentrations will be presented. Funding from EPSRC acknowledged (Grants EP/K006088/1 and EP/K006142/1).

  7. The importance of earthquake-induced landslides to long-term slope erosion and slope-failure hazards in seismically active regions

    USGS Publications Warehouse

    Keefer, D.K.

    1994-01-01

    This paper describes a general method for determining the amount of earthquake-induced landsliding that occurs in a seismically active region over time; this determination can be used as a quantitative measure of the long-term hazard from seismically triggered landslides as well as a measure of the importance of this process to regional slope-erosion rates and landscape evolution. The method uses data from historical earthquakes to relate total volume of landslide material dislodged by an earthquake to the magnitude, M, and seismic moment, M0, of the earthquake. From worldwide data, a linear-regression relation between landslide volume, V, and M0 is determined as: V = M0/1018.9(?? 0.13), where V is measured in m3 and M0 is in dyn-cm. To determine the amount of earthquake-generated landsliding over time, this relation is combined with data on seismic-moment release for a particular region, which may be derived from either earthquake-history or fault-slip data. The form of the M0-V relation allows the rate of production of earthquake-induced landslides over time to be determined from total rate of seismic-moment release without regard to the distribution of individual events, thus simplifying and generalizing the determination. Application of the method to twelve seismically active regions, with areas ranging from 13,275 to 2,308,000 km2, shows that erosion rates from earthquake-induced landslides vary significantly from region to region. Of the regions studied, the highest rates were determined for the island of Hawaii, New Zealand, western New Guinea, and the San Francisco Bay region of California. Significantly lower rates were determined for Iran, Tibet, the Sierra Nevada-Great Basin region of California, and central Japan (for the time period from 715 AD to the present). Intermediate rates were determined for Peru, southern California, onshore California, Turkey, and central Japan (for the time period from 1586 AD to the present). To determine the relative, long

  8. Reversible activation of the neutrophil superoxide generating system by hexachlorocyclohexane: correlation with effects on a subcellular superoxide-generating fraction.

    PubMed

    English, D; Schell, M; Siakotos, A; Gabig, T G

    1986-07-01

    gamma-Hexachlorocyclohexane was found to exert profound effects on the phosphatidylinositol cycle, cytosolic calcium level, and the respiratory burst of human neutrophils. Exposure of neutrophils prelabelled with 32P to 4 X 10(-4) M gamma-hexachlorocyclohexane almost tripled radioactivity in phosphatidic acid and correspondingly decreased radioactivity in phosphatidylinositol 4,5 bisphosphate. Under similar conditions, gamma-hexachlorocyclohexane evoked the generation of superoxide at a rate of over 11 nmol/min/10(6) cells and more than doubled cytosolic-free calcium concentration as monitored by Quin-2 fluorescence. Because intermediates of the phosphatidylinositol cycle, via increases in available calcium levels or activated protein kinase C, are considered potential second messengers for activation of the NADPH-dependent O-2-generating system, we compared neutrophil responses to gamma-hexachlorocyclohexane with responses to phorbol myristate acetate, an activator of protein kinase C with well known effects on neutrophils. Like phorbol myristate acetate, gamma-hexachlorocyclohexane induced neutrophil degranulation but was not an effective chemotactic stimulus. The ability of gamma-hexachlorocyclohexane to induce a pattern of oxidative activation in neutrophil cytoplasts similar to that in intact cells indicated that concurrent degranulation was not required for sustained O-2 generation in response to this agent. When neutrophils or neutrophil cytoplasts exposed to gamma-hexachlorocyclohexane were centrifuged and resuspended in stimulus-free medium, O-2 generation ceased entirely but could be reinitiated by addition of the same stimulus. This finding was in contrast to the continued O-2 production by phorbol myristate acetate-stimulated neutrophils similarly washed and resuspended in stimulus-free medium. Unlike subcellular fractions of phorbol myristate acetate-stimulated neutrophils, corresponding fractions prepared from gamma

  9. Hazardous waste: cleanup and prevention

    USGS Publications Warehouse

    Vandas, Stephen; Cronin, Nancy L.; Farrar, Frank; Serrano, Guillermo Eliezer Ávila; Yajimovich, Oscar Efraín González; Muñoz, Aurora R.; Rivera, María del C.

    1996-01-01

    Our lifestyles are supported by complex Industrial activities that produce many different chemicals and chemical wastes. The Industries that produce our clothing, cars, medicines, paper, food, fuels, steel, plastics, and electric components use and discard thousands of chemicals every year. At home we may use lawn chemicals, solvents, disinfectants, cleaners, and auto products to Improve our quality of life. A chemical that presents a threat or unreasonable risk to people or the environment Is a hazardous material. When a hazardous material can no longer be used, It becomes a hazardous waste. Hazardous wastes come from a variety of sources, from both present and past activities. Impacts to human health and the environment can result from Improper handling and disposal of hazardous waste.

  10. Assessing hazard risk, cost of adaptation and traditional land use activities in the context of permafrost thaw in communities in Yukon and the Northwest Territories, Canada

    NASA Astrophysics Data System (ADS)

    Benkert, B.; Perrin, A.; Calmels, F.

    2015-12-01

    Together with its partners, the Northern Climate ExChange (NCE, part of the Yukon Research Centre at Yukon College) has been mapping permafrost-related hazard risk in northern communities since 2010. By integrating geoscience and climate project data, we have developed a series of community-scale hazard risk maps. The maps depict hazard risk in stoplight colours for easy interpretation, and support community-based, future-focused adaptation planning. Communities, First Nations, consultants and local regulatory agencies have used the hazard risk maps to site small-scale infrastructure projects, guide land planning processes, and assess suitability of land development applications. However, we know that assessing risk is only one step in integrating the implications of permafrost degradation in societal responses to environmental change. To build on our permafrost hazard risk maps, we are integrating economic principles and traditional land use elements. To assess economic implications of adaptation to permafrost change, we are working with geotechnical engineers to identify adaptation options (e.g., modified building techniques, permafrost thaw mitigation approaches) that suit the risks captured by our existing hazard risk maps. We layer this with an economic analysis of the costs associated with identified adaptation options, providing end-users with a more comprehensive basis upon which to make decisions related to infrastructure. NCE researchers have also integrated traditional land use activities in assessments of permafrost thaw risk, in a project led by Jean Marie River First Nation in the Northwest Territories. Here, the implications of permafrost degradation on food security and land use priorities were assessed by layering key game and gathering areas on permafrost thaw vulnerability maps. Results indicated that close to one quarter of big and small game habitats, and close to twenty percent of key furbearer and gathering areas within the First Nation

  11. Active fiber composites for the generation of Lamb waves.

    PubMed

    Birchmeier, M; Gsell, D; Juon, M; Brunner, A J; Paradies, R; Dual, J

    2009-01-01

    Active fiber composites (AFC) are thin and conformable transducer elements with orthotropic material properties, since they are made of one layer of piezoelectric ceramic fibers. They are suitable for applications in structural health monitoring systems (SHM) with acoustic non-destructive testing methods (NDT). In the presented work the transfer behavior of an AFC as an emitter of transient elastic waves in plate-like structures is investigated. The wave field emitted by an AFC surface bonded on an isotropic plate was simulated with the finite-difference method. The model includes the piezoelectric element and the plate and allows the simulation of the elastic wave propagation. For comparison with the model experiments using a laser interferometer for non-contact measurements of particle velocities at different points around the AFC on the surface of the plate were performed. Transfer functions defined as the ratio of the electric voltage excitation signal and the resulting surface velocity at a specific point are separately determined for the two fundamental Lamb wave modes. In order to take the orthotropic behavior of the AFC into account the transfer functions are determined for several points around the AFC. Results show that the AFC is capable to excite the fundamental symmetric and antisymmetric Lamb wave mode. The antisymmetric mode is mainly radiated in the direction of the piezoelectric fibers, while the symmetric mode is spread over a larger angle. The amplitudes of the emitted waves depend on the frequency of the excitation as well as on the geometric dimensions of the transducer.

  12. When the hazard you're monitoring is the least of your troubles… the early days of a ubiquitous computing citizen science initiative on active volcanoes

    NASA Astrophysics Data System (ADS)

    van Manen, S. M.; Richards, M.; Seaton, R.; Cameron, I.; Avard, G.; Martinez, M.

    2014-12-01

    Approximately 500 million people live in close proximity to one or more of the world's 1500 active volcanoes, and this number is set to increase through population growth. The corresponding human, social, environmental and economic costs of volcanic activity are likewise set to rise. Monitoring of active volcanoes is imperative to minimize the impact of volcanic activity. However, people's responses towards risk are not just determined by objective scientific information, but also by socio-cognitive factors such as hazard salience; risk perception; anxiety levels and sense of self efficacy. This project aims to take a citizen science approach to the monitoring of hazardous volcanic gases: a low-cost automated ubiquitous technology station will increase spatial and temporal data resolution while providing citizens access to relevant, accurate, timely and local information. This means a single data stream can be used to develop a better understanding of volcanic degassing and raise levels of hazard salience and increase feelings of self efficacy. A year and two prototypes into the project, this work presents the lessons learnt to date. Careful consideration was given to the station design in light of the harsh conditions it may encounter. Once the first prototypes were built, results from the initial lab tests were encouraging. Yet it wasn't until the stations were taken into the field that unexpected challenges were encountered: humans. During the very first field trial the prototype was vandalised, our second attempt was thwarted by customs and courier services. As a result, we've had to be flexible in our approach and adapt our strategy and station design in response to these events, which will eventually result in a better outcome. However, this case study serves as a reminder of the importance of considering factors beyond the equipment, data, interpretation and involvement of the public, when planning and implementing a citizen science initiative.

  13. Infrasound Monitoring of Natural Hazards

    NASA Astrophysics Data System (ADS)

    Arrowsmith, S.

    2015-12-01

    Infrasound is generated by a wide variety of energetic natural and anthropogenic phenomena that originate in the solid earth, ocean, and atmosphere. Because the absorption of infrasound is low, it can propagate long distances through atmospheric waveguides, making it a valuable tool for remote monitoring of hazards. Advances in using infrasound for monitoring energetic events in the solid earth, oceans, and atmosphere are being driven by the wealth of new datasets in addition to advances in modeling source and propagation physics. This presentation provides an overview of recent advances in infrasound monitoring of natural hazards, focusing on selected hazards in the earth (earthquakes and volcanoes), ocean (tsunamis), and atmosphere (meteoroids).

  14. A Bayesian Seismic Hazard Analysis for the city of Naples

    NASA Astrophysics Data System (ADS)

    Faenza, Licia; Pierdominici, Simona; Hainzl, Sebastian; Cinti, Francesca R.; Sandri, Laura; Selva, Jacopo; Tonini, Roberto; Perfetti, Paolo

    2016-04-01

    In the last years many studies have been focused on determination and definition of the seismic, volcanic and tsunamogenic hazard in the city of Naples. The reason is that the town of Naples with its neighboring area is one of the most densely populated places in Italy. In addition, the risk is increased also by the type and condition of buildings and monuments in the city. It is crucial therefore to assess which active faults in Naples and surrounding area could trigger an earthquake able to shake and damage the urban area. We collect data from the most reliable and complete databases of macroseismic intensity records (from 79 AD to present). For each seismic event an active tectonic structure has been associated. Furthermore a set of active faults, well-known from geological investigations, located around the study area that they could shake the city, not associated with any earthquake, has been taken into account for our studies. This geological framework is the starting point for our Bayesian seismic hazard analysis for the city of Naples. We show the feasibility of formulating the hazard assessment procedure to include the information of past earthquakes into the probabilistic seismic hazard analysis. This strategy allows on one hand to enlarge the information used in the evaluation of the hazard, from alternative models for the earthquake generation process to past shaking and on the other hand to explicitly account for all kinds of information and their uncertainties. The Bayesian scheme we propose is applied to evaluate the seismic hazard of Naples. We implement five different spatio-temporal models to parameterize the occurrence of earthquakes potentially dangerous for Naples. Subsequently we combine these hazard curves with ShakeMap of past earthquakes that have been felt in Naples. The results are posterior hazard assessment for three exposure times, e.g., 50, 10 and 5 years, in a dense grid that cover the municipality of Naples, considering bedrock soil

  15. Implementation of the hazardous debris rule

    SciTech Connect

    Sailer, J.E.

    1993-01-05

    Hazardous debris includes objects contaminated with hazardous waste. Examples of debris include tree stumps, timbers, boulders, tanks, piping, crushed drums, personal protective clothing, etc. Most of the hazardous debris encountered comes from Superfund sites and other facility remediation, although generators and treaters of hazardous waste also generate hazardous debris. Major problems associated with disposal of debris includes: Inappropriateness of many waste treatments to debris; Difficulties in obtaining representative samples; Costs associated with applying waste specific treatments to debris; Subtitle C landfill space was being used for many low hazard debris types. These factors brought about the need for debris treatment technologies and regulations that addressed these issues. The goal of such regulation was to provide treatment to destroy or remove the contamination if possible and, if this is achieved, to dispose of the cleaned debris as a nonhazardous waste. EPA has accomplished this goal through promulgation of the Hazardous Debris Rule, August 18, 1992.

  16. 75 FR 57686 - Hazardous Waste Management System; Identification and Listing of Hazardous Waste Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... AGENCY 40 CFR Part 261 Hazardous Waste Management System; Identification and Listing of Hazardous Waste... specific waste from a particular generating facility should not be regulated as a hazardous waste. Based on waste-specific information provided by the petitioner, EPA granted an exclusion for up to 3,000...

  17. 75 FR 60689 - Hazardous Waste Management System; Identification and Listing of Hazardous Waste; Proposed Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... AGENCY 40 CFR Part 261 Hazardous Waste Management System; Identification and Listing of Hazardous Waste... Refinery (Beaumont Refinery) to exclude (or delist) a certain solid waste generated by its Beaumont, Texas, facility from the lists of hazardous wastes. EPA used the Delisting Risk Assessment Software (DRAS)...

  18. 75 FR 58346 - Hazardous Waste Management System; Identification and Listing of Hazardous Waste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... AGENCY 40 CFR Part 261 Hazardous Waste Management System; Identification and Listing of Hazardous Waste...) certain solid wastes generated by its Longview, Texas, facility from the lists of hazardous wastes. EPA... petitioned waste on human health and the environment. DATES: Comments must be received on or before...

  19. Leveling the Playing Field: First Generation Korean American Males and School Based Extracurricular Activities

    ERIC Educational Resources Information Center

    Levy, Corey

    2010-01-01

    This study examined the manner in which extracurricular activities impacted the acculturation of first-generation adolescent males. Specifically, the project focused on the influence of organized high school soccer on the development of first-generation adolescent Korean American males. Eight adolescent participants, ranging in age from fourteen…

  20. 75 FR 12989 - Hazardous Waste Technical Corrections and Clarifications Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ...The Environmental Protection Agency (EPA or the Agency) is taking Direct Final action on a number of technical changes that correct or clarify several parts of the Resource Conservation and Recovery Act (RCRA) hazardous waste regulations that relate to hazardous waste identification, manifesting, the hazardous waste generator requirements, standards for owners and operators of hazardous waste......

  1. Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity.

    PubMed

    Sessolo, Michele; Marcon, Iacopo; Bovetti, Serena; Losi, Gabriele; Cammarota, Mario; Ratto, Gian Michele; Fellin, Tommaso; Carmignoto, Giorgio

    2015-07-01

    Parvalbumin (Pv)-positive inhibitory interneurons effectively control network excitability, and their optogenetic activation has been reported to block epileptic seizures. An intense activity in GABAergic interneurons, including Pv interneurons, before seizures has been described in different experimental models of epilepsy, raising the hypothesis that an increased GABAergic inhibitory signal may, under certain conditions, initiate seizures. It is therefore unclear whether the activity of Pv interneurons enhances or opposes epileptiform activities. Here we use a mouse cortical slice model of focal epilepsy in which the epileptogenic focus can be identified and the role of Pv interneurons in the generation and propagation of seizure-like ictal events is accurately analyzed by a combination of optogenetic, electrophysiological, and imaging techniques. We found that a selective activation of Pv interneurons at the focus failed to block ictal generation and induced postinhibitory rebound spiking in pyramidal neurons, enhancing neuronal synchrony and promoting ictal generation. In contrast, a selective activation of Pv interneurons distant from the focus blocked ictal propagation and shortened ictal duration at the focus. We revealed that the reduced ictal duration was a direct consequence of the ictal propagation block, probably by preventing newly generated afterdischarges to travel backwards to the original focus of ictal initiation. Similar results were obtained upon individual Pv interneuron activation by intracellular depolarizing current pulses. The functional dichotomy of Pv interneurons here described opens new perspectives to our understanding of how local inhibitory circuits govern generation and spread of focal epileptiform activities.

  2. Active Fault Mapping of Naga-Disang Thrust (Belt of Schuppen) for Assessing Future Earthquake Hazards in NE India

    NASA Astrophysics Data System (ADS)

    Kumar, A.

    2014-12-01

    We observe the geodynamic appraisal of Naga-Disang Thrust North East India. The Disang thrust extends NE-SW over a length of 480 km and it defines the eastern margin of Neogene basin. It branches out from Haflong-Naga thrust and in the NE at Bulbulia in the right bank of Noa Dihing River, it is terminated by Mishmi thrust, which extends into Myanmar as 'Sagaing fault,which dip generally towards SE. It extends between Dauki fault in the SW and Mishmi thrust in the NE. When the SW end of 'Belt of Schuppen' moved upwards and towards east along the Dauki fault, the NE end moved downwards and towards west along the Mishmi thrust, causing its 'S' shaped bending. The SRTM generated DEM is used to map the topographic expression of the schuppen belt, where these thrusts are significantly marked by topographic break. Satellite imagery map also shows presence lineaments supporting the post tectonic activities along Naga-Disang Thrusts. The southern part of 'Belt of Schuppen' extends along the sheared western limb of southerly plunging Kohima synform, a part of Indo Burma Ranges (IBR) and it is seismically active.The crustal velocity at SE of Schuppen is 39.90 mm/yr with a azimuth of 70.780 at Lumami, 38.84 mm/yr (Azimuth 54.09) at Senapati and 36.85 mm/yr (Azimuth 54.09) at Imphal. The crustal velocity at NW of Schuppen belt is 52.67 mm/yr (Azimuth 57.66) near Dhauki Fault in Meghalaya. It becomes 43.60 mm/yr (Azimuth76.50) - 44.25 (Azimuth 73.27) at Tiding and Kamlang Nagar around Mishmi thrust. The presence of Schuppen is marked by a change in high crustal velocity from Indian plate to low crustal velocity in Mishmi Suture as well as Indo Burma Ranges. The difference in crustal velocities results in building up of strain along the Schuppen which may trigger a large earthquake in the NE India in future. The belt of schuppean seems to be seismically active, however, the enough number of large earthquakes are not recorded. These observations are significant on Naga

  3. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.

    PubMed Central

    Rachmilewitz, D; Stamler, J S; Bachwich, D; Karmeli, F; Ackerman, Z; Podolsky, D K

    1995-01-01

    Recent studies have suggested that nitric oxide (NO.), the product of nitric oxide synthase in inflammatory cells, may play a part in tissue injury and inflammation through its oxidative metabolism. In this study the colonic generation of oxides of nitrogen (NOx) and nitric oxide synthase activity was determined in ulcerative colitis and Crohn's disease. Colonic biopsy specimens were obtained from inflammatory bowel disease patients and from normal controls. Mucosal explants were cultured in vitro for 24 hours and NOx generation was determined. Nitric oxide synthase activity was monitored by the conversion of [3H]-L-arginine to citrulline. Median NOx generation by inflamed colonic mucosa of patients with active ulcerative colitis and Crohn's colitis was 4.2- and 8.1-fold respectively higher than that by normal human colonic mucosa. In ulcerative colitis and Crohn's colitis nitric oxide synthase activity was 10.0- and 3.8-fold respectively higher than in normal subjects. Colonic NOx generation is significantly decreased by methylprednisolone and ketotifen. The decrease in NOx generation by cultured colonic mucosa induced by methylprednisolone suggests that NO synthase activity is induced during the culture and the steroid effect may contribute to its therapeutic effect. Enhanced colonic NOx generation by stimulated nitric oxide synthase activity in ulcerative colitis and Crohn's disease may contribute to tissue injury. PMID:7541008

  4. NASA Hazard Analysis Process

    NASA Technical Reports Server (NTRS)

    Deckert, George

    2010-01-01

    This viewgraph presentation reviews The NASA Hazard Analysis process. The contents include: 1) Significant Incidents and Close Calls in Human Spaceflight; 2) Subsystem Safety Engineering Through the Project Life Cycle; 3) The Risk Informed Design Process; 4) Types of NASA Hazard Analysis; 5) Preliminary Hazard Analysis (PHA); 6) Hazard Analysis Process; 7) Identify Hazardous Conditions; 8) Consider All Interfaces; 9) Work a Preliminary Hazard List; 10) NASA Generic Hazards List; and 11) Final Thoughts

  5. 2013 Los Alamos National Laboratory Hazardous Waste Minimization Report

    SciTech Connect

    Salzman, Sonja L.; English, Charles J.

    2015-08-24

    Waste minimization and pollution prevention are inherent goals within the operating procedures of Los Alamos National Security, LLC (LANS). The US Department of Energy (DOE) and LANS are required to submit an annual hazardous waste minimization report to the New Mexico Environment Department (NMED) in accordance with the Los Alamos National Laboratory (LANL or the Laboratory) Hazardous Waste Facility Permit. The report was prepared pursuant to the requirements of Section 2.9 of the LANL Hazardous Waste Facility Permit. This report describes the hazardous waste minimization program (a component of the overall Waste Minimization/Pollution Prevention [WMin/PP] Program) administered by the Environmental Stewardship Group (ENV-ES). This report also supports the waste minimization and pollution prevention goals of the Environmental Programs Directorate (EP) organizations that are responsible for implementing remediation activities and describes its programs to incorporate waste reduction practices into remediation activities and procedures. LANS was very successful in fiscal year (FY) 2013 (October 1-September 30) in WMin/PP efforts. Staff funded four projects specifically related to reduction of waste with hazardous constituents, and LANS won four national awards for pollution prevention efforts from the National Nuclear Security Administration (NNSA). In FY13, there was no hazardous, mixedtransuranic (MTRU), or mixed low-level (MLLW) remediation waste generated at the Laboratory. More hazardous waste, MTRU waste, and MLLW was generated in FY13 than in FY12, and the majority of the increase was related to MTRU processing or lab cleanouts. These accomplishments and analysis of the waste streams are discussed in much more detail within this report.

  6. Electrostatic power generation using carbon-activated cotton thread on textile

    NASA Astrophysics Data System (ADS)

    Kim, Baek Hyun; Barnhart, Benjamin S.; Kwon, Jae W.

    2015-12-01

    This paper describes a novel thread-shaped power generator which can be incorporated into cloth. A carbon-activated cotton thread is utilized for harvesting electrostatic energy from environment using contact and friction electrifications. A core of cotton thread was treated with carbon black nano particles to provide conductivity, and then encapsulated with a thin layer of polydimethylsiloxane for stability and protection. Electrostatic charges have been collected from carbon-activated threads stitched on pieces of textiles by repeated rubbing and tapping with a ploytetrafluoethylene sheet. An average open-circuit voltage of approximately -60.9 V has been generated from the thread-shaped generator with rubbing mode.

  7. Parametric studies with an atmospheric diffusion model that assesses toxic fuel hazards due to the ground clouds generated by rocket launches

    NASA Technical Reports Server (NTRS)

    Stewart, R. B.; Grose, W. L.

    1975-01-01

    Parametric studies were made with a multilayer atmospheric diffusion model to place quantitative limits on the uncertainty of predicting ground-level toxic rocket-fuel concentrations. Exhaust distributions in the ground cloud, cloud stabilized geometry, atmospheric coefficients, the effects of exhaust plume afterburning of carbon monoxide CO, assumed surface mixing-layer division in the model, and model sensitivity to different meteorological regimes were studied. Large-scale differences in ground-level predictions are quantitatively described. Cloud alongwind growth for several meteorological conditions is shown to be in error because of incorrect application of previous diffusion theory. In addition, rocket-plume calculations indicate that almost all of the rocket-motor carbon monoxide is afterburned to carbon dioxide CO2, thus reducing toxic hazards due to CO. The afterburning is also shown to have a significant effect on cloud stabilization height and on ground-level concentrations of exhaust products.

  8. A Curriculum Activities Guide to Electric Power Generation and the Environment.

    ERIC Educational Resources Information Center

    Tully, Randolph R., Jr., Ed.

    This guide was developed by teachers involved in a workshop on "Electric Power Generation and the Environment." Activity topics are: (1) Energy and the Consumer; (2) Energy and Water Pollution; and (3) Energy and Air Pollution. Within these topics, the activities are classified as awareness level, transitional level, or operational…

  9. Exploring Preferences of Mentoring Activities among Generational Groups of Registered Nurses in Florida

    ERIC Educational Resources Information Center

    Posey-Goodwin, Patricia Ann

    2013-01-01

    The purpose of this study was to explore differences in perceptions of mentoring activities from four generations of registered nurses in Florida, using the Alleman Mentoring Activities Questionnaire ® (AMAQ ®). Statistical procedures of analysis of variance (ANOVA) were employed to explore differences among 65 registered nurses in Florida from…

  10. Contradictions between the Virtual and Physical High School Classroom: A Third-Generation Activity Theory Perspective

    ERIC Educational Resources Information Center

    Murphy, Elizabeth; Manzanares, Maria A. Rodriguez

    2008-01-01

    This paper uses a third-generation Activity Theory perspective to gain insight into the contradictions between the activity systems of the physical and virtual high school classroom from the perspective of teachers who had transitioned from one system to the other. Data collection relied on semi-structured interviews conducted with e-teachers as…

  11. An Evaluation of a Wide Range of Job-Generating Activities for Rural Counties.

    ERIC Educational Resources Information Center

    Finsterbusch, Kurt; And Others

    1992-01-01

    Examines the job-generating activities in 15 rural counties in Maryland through 175 interviews and field work. Those ranking high included industrial park development, economic development activities, and tourism. Special financial arrangements for relocating and new businesses also received high marks. Includes 48 references. (JOW)

  12. Analysing Third Generation Activity Systems: Labour-Power, Subject Position and Personal Transformation

    ERIC Educational Resources Information Center

    Daniels, Harry; Warmington, Paul

    2007-01-01

    Purpose: The purpose of this paper is to describe how Engestrom's "third generation" activity theory, with its emphasis on developing conceptual tools to understand dialogues, multiple perspectives and networks of interacting activity systems, has informed research into professional learning in multiagency service settings in England.…

  13. Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid*

    PubMed Central

    Hinz, Christine; Aldrovandi, Maceler; Uhlson, Charis; Marnett, Lawrence J.; Longhurst, Hilary J.; Warner, Timothy D.; Alam, Saydul; Slatter, David A.; Lauder, Sarah N.; Allen-Redpath, Keith; Collins, Peter W.; Murphy, Robert C.; Thomas, Christopher P.; O'Donnell, Valerie B.

    2016-01-01

    Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombin-activated human platelets generate a new type of eicosanoid that both stimulates and primes human neutrophil integrin (Mac-1) expression, in response to formylmethionylleucylphenylalanine. Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3). The lipid is generated in nanogram amounts by platelets from endogenous arachidonate during physiological activation, with inhibition by aspirin in vitro or in vivo, implicating cyclooxygenase-1 (COX). Pharmacological and genetic studies on human/murine platelets revealed that DXA3 formation requires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases, p38 MAPK, phospholipase C, and intracellular calcium. From data generated by purified COX isoforms and chemical oxidation, we propose that DXA3 is generated by release of an intermediate from the active site followed by oxygenation at C8. In summary, a new neutrophil-activating platelet-derived lipid generated by COX-1 is presented that can activate or prime human neutrophils, suggesting a role in innate immunity and acute inflammation. PMID:27129261

  14. Beyond participation: the association between school extracurricular activities and involvement in violence across generations of immigration.

    PubMed

    Jiang, Xin; Peterson, Ruth D

    2012-03-01

    Participation in extracurricular activities is purported to protect the broad spectrum of youth from a host of behavioral risks. Yet, empirical research on the extent to which this assumption holds for involvement in violence by immigrant youth is limited. Thus, using data for 13,236 (51.8% female) adolescents from the National Longitudinal Study of Adolescent Health, this study explores how the relationship between extracurricular activities and youth violence varies by type of extracurricular activity profile (sports alone, non-sports alone, and a combination of sports and non-sports) and by generations of immigration (first, second, and third-plus). The sample is composed of 9.3% (n = 1,233) first-generation youth, 15.7% (n = 2,080) second generation, and 74.9% (n = 9,923) third-plus generation. The results reveal that adolescents from the third-plus generation (i.e., non-immigrant youth) who participate in non-sports alone or sports plus non-sports have lower odds of involvement in violence than adolescents from the same generation who do not participate in extracurricular activities. However, for first- and second-generation adolescents, participation in extracurricular activities is associated with higher rather than lower odds of violence compared to their non-participating counterparts. These findings challenge the viewpoint that participation in mainstream extracurricular activities as afforded by US schools is equally beneficial for all youth. They also call for additional research that explores why immigrant youth are less likely than non-immigrant youth to gain violence-reducing benefits when they participate in extracurricular activities.

  15. Estimation of the activity generated by neutron activation in control rods of a BWR.

    PubMed

    Ródenas, José; Gallardo, Sergio; Abarca, Agustín; Juan, Violeta

    2010-01-01

    Control rods are activated by neutron reactions into the reactor. The activation is produced mainly in stainless steel and its impurities. The dose produced by this activity is not important inside the reactor, but it has to be taken into account when the rod is withdrawn from the reactor. Activation reactions produced have been modelled by the MCNP5 code based on the Monte Carlo method. The code gives the number of reactions that can be converted into activity.

  16. Future of low specific activity molybdenum-99/technetium-99m generator.

    PubMed

    Mushtaq, A

    2012-10-01

    In last few years, the shortage of molybdenum-99 (99Mo) was felt in the developed and developing countries hospitals, where diagnostic nuclear medicine is practiced. To overcome the shortage of 99Mo various routes of its production by accelerators and reactors generating low and high specific activity products have been planned. High specific activity 99Mo obtained by fission of uranium-235 (235U) has completely dominated in the manufacturing of technetium-99m (99mTc) generators in last 3-4 decades, but due to proliferation and dirty bomb, issues non fission routes of 99Mo production are emphasized. Future of low specific activity 99Mo is discussed.

  17. Hazardous waste minimization report for CY 1986

    SciTech Connect

    Kendrick, C.M.

    1990-12-01

    Oak Ridge National Laboratory (ORNL) is a multipurpose research and development facility. Its primary role is the support of energy technology through applied research and engineering development and scientific research in basic and physical sciences. ORNL also is a valuable resource in the solution of problems of national importance, such as nuclear and chemical waste management. In addition, useful radioactive and stable isotopes which are unavailable from the private sector are produced at ORNL. As a result of these activities, hazardous, radioactive, and mixed wastes are generated at ORNL. A formal hazardous waste minimization program for ORNL was launched in mid 1985 in response to the requirements of Section 3002 of the Resource Conservation and Recovery Act (RCRA). During 1986, a task plan was developed. The six major tasks include: planning and implementation of a laboratory-wide chemical inventory and the subsequent distribution, treatment, storage, and/or disposal (TSD) of unneeded chemicals; establishment and implementation of a distribution system for surplus chemicals to other (internal and external) organizations; training and communication functions necessary to inform and motivate laboratory personnel; evaluation of current procurement and tracking systems for hazardous materials and recommendation and implementation of improvements; systematic review of applicable current and proposed ORNL procedures and ongoing and proposed activities for waste volume and/or toxicity reduction potential; and establishment of criteria by which to measure progress and reporting of significant achievements. 8 refs., 1 fig., 5 tabs.

  18. Latest Pleistocene-Holocene debris flow activity, Santa Catalina Mountains, Arizona; Implications for modern debris-flow hazards under a changing climate

    NASA Astrophysics Data System (ADS)

    Youberg, Ann M.; Webb, Robert H.; Fenton, Cassandra R.; Pearthree, Philip A.

    2014-08-01

    Hazard mitigation for extreme events such as debris flows requires geologic mapping and chronologic information, particularly for alluvial fans near mountain fronts in the southwestern United States. In July 2006, five consecutive days of monsoonal storms caused hundreds of debris flows in southeastern Arizona, particularly in the southern Santa Catalina Mountains north of Tucson. Before 2006, no historical debris flows from the Santa Catalina Mountains reached the populated mountain front, although abundant evidence of prehistoric debris flows is present on downslope alluvial fans. We used a combination of surficial geologic mapping and 10Be exposure dating to produce a debris-flow history for Pima and Finger Rock Canyons. The largest debris flows, of latest Pleistocene to early Holocene age, covered much of the apices of alluvial fans formed at the mouths of these canyons and extended up to 3 km downslope. These debris-flow deposits were inset against higher and older alluvial surfaces with few debris-flow deposits of late Pleistocene age. The 10Be ages in this study have considerable scatter for surfaces believed to be of uniform age, indicating the dual possibilities of inheritance from previous cosmic-ray exposure, as well as the potential for composite deposits derived from numerous debris flows. We then used an empirical inundation model, LAHARZ, to assess probable magnitudes of the older debris flows to evaluate possible initiation mechanisms. In-channel and terrace storage within the canyons is not sufficient to generate volumes likely needed to produce the larger late Pleistocene to early Holocene debris-flow deposits. The abundance of latest Pleistocene and early Holocene deposits suggests that large debris flows were generated during the instability associated with climate and vegetation changes at the Pleistocene-Holocene transition. Under present watershed conditions with limited sediment supplies, modern debris-flow hazards are generally limited to

  19. Entropy Generation and Human Aging: Lifespan Entropy and Effect of Physical Activity Level

    NASA Astrophysics Data System (ADS)

    Silva, Carlos; Annamalai, Kalyan

    2008-06-01

    The first and second laws of thermodynamics were applied to biochemical reactions typical of human metabolism. An open-system model was used for a human body. Energy conservation, availability and entropy balances were performed to obtain the entropy generated for the main food components. Quantitative results for entropy generation were obtained as a function of age using the databases from the U.S. Food and Nutrition Board (FNB) and Centers for Disease Control and Prevention (CDC), which provide energy requirements and food intake composition as a function of age, weight and stature. Numerical integration was performed through human lifespan for different levels of physical activity. Results were presented and analyzed. Entropy generated over the lifespan of average individuals (natural death) was found to be 11,404 kJ/ºK per kg of body mass with a rate of generation three times higher on infants than on the elderly. The entropy generated predicts a life span of 73.78 and 81.61 years for the average U.S. male and female individuals respectively, which are values that closely match the average lifespan from statistics (74.63 and 80.36 years). From the analysis of the effect of different activity levels, it is shown that entropy generated increases with physical activity, suggesting that exercise should be kept to a “healthy minimum” if entropy generation is to be minimized.

  20. Generation, Language, Body Mass Index, and Activity Patterns in Hispanic Children

    PubMed Central

    Taverno, Sharon E.; Rollins, Brandi Y.; Francis, Lori A.

    2010-01-01

    Background The acculturation hypothesis proposes an overall disadvantage in health outcomes for Hispanic immigrants with more time spent living in the U.S., but little is known about how generational status and language may influence Hispanic children’s relative weight and activity patterns. Purpose The association between generation and language was investigated with relative weight (BMI z-scores), physical activity, screen time, and participation in extracurricular activities (e.g., sports, clubs) in a U.S.-based, nationally representative sample of Hispanic children. Methods Participants included 2,012 Hispanic children aged 6–11 years from the cross-sectional, 2003 National Survey of Children’s Health. Children were grouped according to generational status (1st, 2nd or 3rd), and the primary language spoken in the home (English vs non-English). Primary analyses included adjusted logistic and multinomial logistic regression to examine the relationships among variables; all analyses were conducted between 2008 and 2009. Results Compared to 3rd generation, English speakers, 1st and 2nd generation, non-English speakers were over two times more likely to be obese. Moreover, 1st generation, non-English speakers were half as likely to engage in regular physical activity and sports. Both 1st and 2nd generation, non-English speakers were less likely to participate in clubs compared to 2nd and 3rd generation, English speakers. Overall, all non–English speaking groups reported less screen time compared to 3rd generation, English speakers. Conclusions The hypothesis that Hispanics lose their health protection with more time spent in the U.S. was not supported in this sample of Hispanic children. PMID:20117570

  1. Measurement of activity concentrations of 40K, 226Ra and 232Th for assessment of radiation hazards from soils of the southwestern region of Nigeria.

    PubMed

    Ajayi, Oladele Samuel

    2009-08-01

    Activity concentrations of the selected radionuclides (40)K, (226)Ra and (232)Th were measured in surface soil samples collected from 38 cities in the southwest region of Nigeria by means of gamma spectroscopy with a high-purity germanium detector. Measured activity concentration values of (40)K varied from 34.9 +/- 4.4 to 1,358.6 +/- 28.5 Bq kg(-1) (given on a dry mass (DM) basis) with a mean value of 286.5 +/- 308.5 Bq kg(-1); that of (226)Ra varied from 9.3 +/- 3.7 to 198.1 +/- 13.8 Bq kg(-1) with a mean value of 54.5 Bq kg(-1) and a standard deviation of 38.7 Bq kg(-1), while that of (232)Th varied from 5.4 +/- 1.1 to 502.0 +/- 16.5 Bq kg(-1) with a mean value of 91.1 Bq kg(-1) and standard deviation of 100.9 Bq kg(-1). The mean activity concentration values obtained for (226)Ra and (232)Th are greater than the world average values reported by the United Nations Scientific Committee on Effects of Atomic Radiation for areas of normal background radiation. Radiological indices were estimated for the radiation/health hazards of the natural radioactivity of all soil samples. Estimated absorbed dose rates in air varied from 12.42 +/- 2.25 to 451.33 +/- 19.06 nGy h(-1), annual outdoor effective dose rates from 0.015 +/- 0.003 to 0.554 +/- 0.023 mSv year(-1), internal hazard index from 0.10 +/- 0.03 to 3.02 +/- 0.16, external hazard index from 0.07 +/- 0.01 to 2.60 +/- 0.11, representative level index from 0.19 +/- 0.03 to 6.84 +/- 0.29, activity index from 0.09 +/- 0.02 to 3.42 +/- 0.15, and radium equivalent activity from 26.95 +/- 5.04 to 963.15 +/- 41.87 Bq kg(-1). Only the mean value of the representative level index exceeds the limit for areas of normal background radiation. All other indices show mean values that are lower than the recommended limits.

  2. Active Oxygen Species Generator by Low Pressure Silent Discharge and its Application to Water Treatment

    NASA Astrophysics Data System (ADS)

    Tanaka, Masaaki; Ikeda, Akira; Tanimura, Yasuhiro; Ohta, Koji; Yoshiyasu, Hajimu

    We have proposed the new water treatment using the active oxygen species such as an atomic oxygen with the oxidation power that is stronger than ozone. Based on the results of simulations we designed the silent discharge type active oxygen generator with a water ejector, which is operated on the discharge conditions of low pressure of 6.6kPa. and high temperature of about 200°C. The experimental results are as follows. (1) The yield of the active oxygen increases with the increase of the discharge tube temperature and the decrease of the gas pressure. (2) The life time of active oxygen is tens msec. (3) The active oxygen oxidizes efficiently the formic acid compared with ozone. It is assumed from these results that the active oxygen species having a strong oxidation power is generated.

  3. Hazardous Environment Robotics

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Jet Propulsion Laboratory (JPL) developed video overlay calibration and demonstration techniques for ground-based telerobotics. Through a technology sharing agreement with JPL, Deneb Robotics added this as an option to its robotics software, TELEGRIP. The software is used for remotely operating robots in nuclear and hazardous environments in industries including automotive and medical. The option allows the operator to utilize video to calibrate 3-D computer models with the actual environment, and thus plan and optimize robot trajectories before the program is automatically generated.

  4. Counterfactual Volcano Hazard Analysis

    NASA Astrophysics Data System (ADS)

    Woo, Gordon

    2013-04-01

    , if a major storm surge happens to arrive at a high astronomical tide, sea walls may be overtopped and flooding may ensue. In the domain of geological hazards, periods of volcanic unrest may generate precursory signals suggestive of imminent volcanic danger, but without leading to an actual eruption. Near-miss unrest periods provide vital evidence for assessing the dynamics of volcanoes close to eruption. Where the volcano catalogue has been diligently revised to include the maximum amount of information on the phenomenology of unrest periods, dynamic modelling and hazard assessment may be significantly refined. This is illustrated with some topical volcano hazard examples, including Montserrat and Santorini.

  5. Volcanic hazards to airports

    USGS Publications Warehouse

    Guffanti, M.; Mayberry, G.C.; Casadevall, T.J.; Wunderman, R.

    2009-01-01

    Volcanic activity has caused significant hazards to numerous airports worldwide, with local to far-ranging effects on travelers and commerce. Analysis of a new compilation of incidents of airports impacted by volcanic activity from 1944 through 2006 reveals that, at a minimum, 101 airports in 28 countries were affected on 171 occasions by eruptions at 46 volcanoes. Since 1980, five airports per year on average have been affected by volcanic activity, which indicates that volcanic hazards to airports are not rare on a worldwide basis. The main hazard to airports is ashfall, with accumulations of only a few millimeters sufficient to force temporary closures of some airports. A substantial portion of incidents has been caused by ash in airspace in the vicinity of airports, without accumulation of ash on the ground. On a few occasions, airports have been impacted by hazards other than ash (pyroclastic flow, lava flow, gas emission, and phreatic explosion). Several airports have been affected repeatedly by volcanic hazards. Four airports have been affected the most often and likely will continue to be among the most vulnerable owing to continued nearby volcanic activity: Fontanarossa International Airport in Catania, Italy; Ted Stevens Anchorage International Airport in Alaska, USA; Mariscal Sucre International Airport in Quito, Ecuador; and Tokua Airport in Kokopo, Papua New Guinea. The USA has the most airports affected by volcanic activity (17) on the most occasions (33) and hosts the second highest number of volcanoes that have caused the disruptions (5, after Indonesia with 7). One-fifth of the affected airports are within 30 km of the source volcanoes, approximately half are located within 150 km of the source volcanoes, and about three-quarters are within 300 km; nearly one-fifth are located more than 500 km away from the source volcanoes. The volcanoes that have caused the most impacts are Soufriere Hills on the island of Montserrat in the British West Indies

  6. Comparison of the hazards posed to amphibians by the glyphosate spray control program versus the chemical and physical activities of coca production in Colombia.

    PubMed

    Brain, Richard A; Solomon, Keith R

    2009-01-01

    This study evaluates the cumulative multifactorial physical and chemical impacts resulting from coca production on amphibian populations in comparison with the potential impacts produced by the herbicide glyphosate (Glyphos), which, mixed with the surfactant Cosmo-Flux, is used in the spray control program for illicit crops in Colombia. Using similar worst-case assumptions for exposure, several other pesticides used for coca production, including mancozeb, lambda cyhalothrin, endosulfan, diazinon, malathion, and chlorpyrifos, were up to 10- to 100-fold more toxic to frogs than the Glyphos-Cosmo-Flux mixture. Comparing hazard quotients based on application rates, several of these compounds demonstrated hazards 3-383 times that of formulated glyphosate. Secondary effects, particularly of insecticides, are also a concern, as these agents selectively target the primary food source of amphibians, which may indirectly impact growth and development. Although the potential chemical impacts by other pesticides are considerable, physical activities associated with coca production, particularly deforestation of primary forests for new coca plots, portend the greatest hazard to amphibian populations. The entire production cycle of cocaine has been linked to ecosystem degradation. The clearing of pristine forests for coca propagation in Colombia is well documented, and some of these regions coincide with those that contain exceptional amphibian biodiversity. This is particularly problematic as coca production encroaches more deeply into more remote areas of tropical rain forest. Transportation of disease, including the chitrid fungus, to these remote regions via human intrusion may also adversely affect amphibian populations. Therefore, the cumulative impacts of coca production, through habitat destruction, application of agrochemicals, and potential transmission of disease, are judged to pose greater risks to amphibian populations in coca-growing regions than the glyphosate

  7. Removal of PCDD/Fs from flue gas by a fixed-bed activated carbon filter in a hazardous waste incinerator.

    PubMed

    Karademir, Aykan; Bakoglu, Mithat; Taspinar, Fatih; Ayberk, Savas

    2004-02-15

    The adsorption of polychlorinated dibenzodioxins and dibenzofurans (PCDD/Fs) by activated carbon (AC) was examined in a fixed-bed AC unit in a hazardous waste incinerator (IZAYDAS) in Turkey. Results showed that the removal efficiencies of PCDD/Fs decrease as the chlorination level increases, which was explained by the difference in gas/particle partitioning of the compounds. Since dioxins are tightly adsorbed by activated carbon, other flue gas constituents showed no clear effect on the dioxin removal. Adsorption kinetics indicated that the adsorption of volatile congeners and homologues fits well with Henry's law, possibly due to the higher gaseous fractions, while the correlation was lower for lowly volatile ones. PCDD/F congeners and homologues had a concentration value up to which no adsorption occurred, which could be attributed to the insufficient contact times at the low concentrations.

  8. The influence of zinc hydroxystannate on reducing toxic gases (CO, NOx and HCN) generation and fire hazards of thermoplastic polyurethane composites.

    PubMed

    Wang, Bibo; Sheng, Haibo; Shi, Yongqian; Song, Lei; Zhang, Yan; Hu, Yuan; Hu, Weizhao

    2016-08-15

    A uniform zinc hydroxystannate (ZnHS) microcube was synthesized to reduce toxicity and fire hazards of thermoplastic polyurethane (TPU) composites using ammonium polyphosphate as a flame retardant agent. The structure, morphology and thermal properties of ZnHS were characterized by X-ray diffraction, transmission electron microscopy and thermogravimetric analysis, respectively. Smoke suppression properties and synergistic flame retardant effect of ZnHS on flame retardant TPU composites were intensively investigated by smoke density test, cone calorimeter test, and thermalgravimetric analysis. Thermogravimetric analysis/infrared spectrometry and tube furnace were employed to evaluate the toxic gases (CO, NOx and HCN) of TPU composites. The incorporation of ZnHS into TPU matrix effectively improved the fire safety and restrained the smoke density, which is attributed to that the char residue catalyzed by ZnHS enhanced barrier effect that reduced peak heat release rate, total heat release, smoke particles and organic volatiles during combustion. Furthermore, the ZnHS synergist demonstrated high efficiency in catalytic degradation of the toxic gases, which obviously decreased total volatiled product and toxic volatiles evolved, such as the CO, HCN and NOx, indicating suppressed toxicity of the TPU composites.

  9. Delisting a Hazardous Waste

    EPA Pesticide Factsheets

    This page discussed the hazardous waste delisting process. A hazardous waste delisting is a rulemaking procedure to amend the list of hazardous wastes to exclude a waste produced at a particular facility.

  10. PUREX facility hazards assessment

    SciTech Connect

    Sutton, L.N.

    1994-09-23

    This report documents the hazards assessment for the Plutonium Uranium Extraction Plant (PUREX) located on the US Department of Energy (DOE) Hanford Site. Operation of PUREX is the responsibility of Westinghouse Hanford Company (WHC). This hazards assessment was conducted to provide the emergency planning technical basis for PUREX. DOE Order 5500.3A requires an emergency planning hazards assessment for each facility that has the potential to reach or exceed the lowest level emergency classification. In October of 1990, WHC was directed to place PUREX in standby. In December of 1992 the DOE Assistant Secretary for Environmental Restoration and Waste Management authorized the termination of PUREX and directed DOE-RL to proceed with shutdown planning and terminal clean out activities. Prior to this action, its mission was to reprocess irradiated fuels for the recovery of uranium and plutonium. The present mission is to establish a passively safe and environmentally secure configuration at the PUREX facility and to preserve that condition for 10 years. The ten year time frame represents the typical duration expended to define, authorize and initiate follow-on decommissioning and decontamination activities.

  11. Sustainable development and next generation's health: a long-term perspective about the consequences of today's activities for food safety.

    PubMed

    Frazzoli, Chiara; Petrini, Carlo; Mantovani, Alberto

    2009-01-01

    Development is defined sustainable when it meets the needs of the present without compromising the ability of future generations to meet their own needs. Pivoting on social, environmental and economic aspects of food chain sustainability, this paper presents the concept of sustainable food safety based on the prevention of risks and burden of poor health for generations to come. Under this respect, the assessment of long-term, transgenerational risks is still hampered by serious scientific uncertainties. Critical issues to the development of a sustainable food safety framework may include: endocrine disrupters as emerging contaminants that specifically target developing organisms; toxicological risks assessment in Countries at the turning point of development; translating knowledge into toxicity indexes to support risk management approaches, such as hazard analysis and critical control points (HACCP); the interplay between chemical hazards and social determinants. Efforts towards the comprehensive knowledge and management of key factors of sustainable food safety appear critical to the effectiveness of the overall sustainability policies.

  12. Volcanic hazards in Central America

    USGS Publications Warehouse

    Rose, William I.; Bluth, Gregg J.S.; Carr, Michael J.; Ewert, John W.; Patino, Lina C.; Vallance, James W.

    2006-01-01

    This volume is a sampling of current scientific work about volcanoes in Central America with specific application to hazards. The papers reflect a variety of international and interdisciplinary collaborations and employ new methods. The book will be of interest to a broad cross section of scientists, especially volcanologists. The volume also will interest students who aspire to work in the field of volcano hazards mitigation or who may want to work in one of Earth’s most volcanically active areas.

  13. Fiscal Year 2014 Annual Report on BNLs Next Generation Safeguards Initiative Human Capital Development Activities

    SciTech Connect

    Pepper, Susan E.

    2014-10-10

    Brookhaven National Laboratory’s (BNL’s) Nonproliferation and National Security Department contributes to the National Nuclear Security Administration Office of Nonproliferation and International Security Next Generation Safeguards Initiative (NGSI) through university engagement, safeguards internships, safeguards courses, professional development, recruitment, and other activities aimed at ensuring the next generation of international safeguards professionals is adequately prepared to support the U.S. safeguards mission. This report is a summary of BNL s work under the NGSI program in Fiscal Year 2014.

  14. Graduation Hazards and Surviving College: A Descriptive Study of the Longitudinal Nature of Low-Income, First Generation, and Minority Student Enrollment and Graduation

    ERIC Educational Resources Information Center

    Novak, Heather

    2012-01-01

    There are ambitious institutional and national goals that aspire to improve the six year graduation rate for undergraduate students. An important element of increasing the overall rate lies in decreasing the educational attainment gaps for low-income, first generation, and other historically underserved students. Comprehensive theoretical…

  15. Inference generation during text comprehension by adults with right hemisphere brain damage: activation failure versus multiple activation.

    PubMed

    Tompkins, Connie A; Fassbinder, Wiltrud; Lehman Blake, Margaret; Baumgaertner, Annette; Jayaram, Nandini

    2004-12-01

    Evidence conflicts as to whether adults with right hemisphere brain damage (RHD) generate inferences during text comprehension. M. Beeman (1993) reported that adults with RHD fail to activate the lexical-semantic bases of routine bridging inferences, which are necessary for comprehension. But other evidence indicates that adults with RHD activate multiple interpretations in various comprehension domains. In addition, the activation of contextually inappropriate interpretations is prolonged for many adults with RHD and predicts poor discourse comprehension. This study contrasted Beeman's activation failure hypothesis with the prediction that adults with RHD would generate multiple interpretations in text comprehension. The relation between activation of textually incompatible inferences and discourse comprehension was also investigated for this group. Thirty-seven adults with RHD and 34 without brain damage listened to brief narratives that required a bridging inference (BI) to integrate the text-final sentence. This final sentence, when isolated from its text, was strongly biased toward a contextually incompatible alternate interpretation (AI). Auditory phoneme strings were presented for lexical decision immediately after each text's initial and final sentence. Adults with RHD were both faster and more accurate in making lexical decisions to BI-related target words in final-sentence position than in initial-sentence position. Thus, contrary to the activation failure hypothesis, adults with RHD generated the lexical-semantic foundations of BIs where they were required by the text. AI generation was evident in accuracy data as well, but not in response time data. This result is partially consistent with the multiple activation view. Finally, greater activation for contextually incompatible interpretations was associated with poorer discourse comprehension performance by adults with RHD.

  16. Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex123

    PubMed Central

    Marcuccilli, Charles J.; Ben-Mabrouk, Faiza; Lew, Sean M.; Goodman, Robert R.; McKhann, Guy M.; Frim, David M.; Kohrman, Michael H.; Schevon, Catherine A.; van Drongelen, Wim

    2016-01-01

    High-gamma (HG; 80-150 Hz) activity in macroscopic clinical records is considered a marker for critical brain regions involved in seizure initiation; it is correlated with pathological multiunit firing during neocortical seizures in the seizure core, an area identified by correlated multiunit spiking and low frequency seizure activity. However, the effects of the spatiotemporal dynamics of seizure on HG power generation are not well understood. Here, we studied HG generation and propagation, using a three-step, multiscale signal analysis and modeling approach. First, we analyzed concurrent neuronal and microscopic network HG activity in neocortical slices from seven intractable epilepsy patients. We found HG activity in these networks, especially when neurons displayed paroxysmal depolarization shifts and network activity was highly synchronized. Second, we examined HG activity acquired with microelectrode arrays recorded during human seizures (n = 8). We confirmed the presence of synchronized HG power across microelectrode records and the macroscale, both specifically associated with the core region of the seizure. Third, we used volume conduction-based modeling to relate HG activity and network synchrony at different network scales. We showed that local HG oscillations require high levels of synchrony to cross scales, and that this requirement is met at the microscopic scale, but not within macroscopic networks. Instead, we present evidence that HG power at the macroscale may result from harmonics of ongoing seizure activity. Ictal HG power marks the seizure core, but the generating mechanism can differ across spatial scales. PMID:27257623

  17. The generation of rhythmic activity in dissociated cultures of rat spinal cord.

    PubMed

    Streit, J; Tscherter, A; Heuschkel, M O; Renaud, P

    2001-07-01

    Locomotion in vertebrates is controlled by central pattern generators in the spinal cord. The roles of specific network architecture and neuronal properties in rhythm generation by such spinal networks are not fully understood. We have used multisite recording from dissociated cultures of embryonic rat spinal cord grown on multielectrode arrays to investigate the patterns of spontaneous activity in randomised spinal networks. We were able to induce similar patterns of rhythmic activity in dissociated cultures as in slice cultures, although not with the same reliability and not always with the same protocols. The most reliable rhythmic activity was induced when a partial disinhibition of the network was combined with an increase in neuronal excitability, suggesting that both recurrent synaptic excitation and neuronal excitability contribute to rhythmogenesis. During rhythmic activity, bursts started at several sites and propagated in variable ways. However, the predominant propagation patterns were independent of the protocol used to induce rhythmic activity. When synaptic transmission was blocked by CNQX, APV, strychnine and bicuculline, asynchronous low-rate activity persisted at approximately 50% of the electrodes and approximately 70% of the sites of burst initiation. Following the bursts, the activity in the interval was transiently suppressed below the level of intrinsic activity. The degree of suppression was proportional to the amount of activity in the preceding burst. From these findings we conclude that rhythmic activity in spinal cultures is controlled by the interplay of intrinsic neuronal activity and recurrent excitation in neuronal networks without the need for a specific architecture.

  18. Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90

    PubMed Central

    Hartl, Brad A.; Hirschberg, Henry; Marcu, Laura; Cherry, Simon R.

    2017-01-01

    The translation of photodynamic therapy (PDT) to the clinical setting has primarily been limited to easily accessible and/or superficial diseases, for which traditional light delivery can be performed noninvasively. Cerenkov radiation, as generated from medically relevant radionuclides, has been suggested as a means to deliver light to deeper tissues noninvasively to overcome this depth limitation. This article investigates the utility of Cerenkov radiation, as generated from the radionuclide yttrium-90, for activating the PDT process using clinically approved aminolevulinic acid at 1.0 mm and also the more efficient porphyrin-based photosensitizer mesotetraphenylporphine with two sulfonate groups on adjacent phenyl rings (TPPS2a) at 1.2 μM. Experiments were conducted with monolayer cultured glioma and breast tumor cell lines. Although aminolevulinic acid proved to be ineffective for generating a therapeutic effect at all but the highest activity levels, TPPS2a produced at least a 20% therapeutic effect at activities ranging from 6 to 60 μCi/well for the C6 glioma cell line. Importantly, these results demonstrate for the first time, to our knowledge, that Cerenkov radiation generated from a radionuclide can be used to activate PDT using clinically relevant photosensitizers. These results therefore provide evidence that it may be possible to generate a phototherapeutic effect in vivo using Cerenkov radiation and clinically relevant photosensitizers. PMID:27481495

  19. Hazardous waste management in the Pacific basin

    SciTech Connect

    Cirillo, R.R.; Chiu, S.; Chun, K.C.; Conzelmann, G.; Carpenter, R.A.; Indriyanto, S.H.

    1994-11-01

    Hazardous waste control activities in Asia and the Pacific have been reviewed. The review includes China (mainland, Hong Kong, and Taiwan), Indonesia, Korea, Malaysia, Papua New Guinea, the Philippines, Singapore, and Thailand. It covers the sources of hazardous waste, the government structure for dealing with hazardous waste, and current hazardous waste control activities in each country. In addition, the hazardous waste program activities of US government agencies, US private-sector organizations, and international organizations are reviewed. The objective of these reviews is to provide a comprehensive picture of the current hazardous waste problems and the waste management approaches being used to address them so that new program activities can be designed more efficiently.

  20. Prothrombin-activator (thromboplastin) generation in the blood of water snake (Natrix piscator).

    PubMed

    Srivastava, V M; Dube, B; Dube, R K; Agarwal, G P

    1981-12-23

    The generation of prothrombin-activator (thromboplastin) in water snake (Natrix piscator) is clearly delayed, compared to a mammalian system, but the final activity is well comparable to that in man, when homologous sources of "phospholipid" (erythrocyte-lysate) and of substrate plasma are employed in one stage "thromboplastin generation test". The use of heterologous source of either of the above reagents resulted in significantly longer clotting times; hence the need for homologous source of above reagents in the test is emphasized for comparative studies on animal haemostasis.

  1. On-Orbit Checkout and Activation of the ISS Oxygen Generation System

    NASA Technical Reports Server (NTRS)

    Bagdigian, Robert M.; Prokhorov, Kimberlee S.

    2007-01-01

    NASA has developed and; deployed an Oxygen Generation System (OGS) into the Destiny Module of the International Space Station (ISS). The major. assembly; included in this system is the Oxygen Generator Assembly. (OGA) which was developed under NASA contract by Hamilton Sundstrand Space Systems International (HSSSI), Inc. This paper summarizes the installation of the system into the Destiny Module, its initial checkout and periodic preventative maintenance activities, and its operational activation. Trade studies and analyses that were conducted with the goal of mitigating on-orbit operational risks are also discussed.

  2. Energy deposition in the earth's atmosphere due to impact of solar activity-generated disturbances

    NASA Technical Reports Server (NTRS)

    Wu, S. T.; Kan, L. C.; Tandberg-Hanssen, E.; Dryer, M.

    1979-01-01

    Energy deposition in and dynamic responses of the terrestrial atmosphere to solar flare-generated shocks and other physical processes - such as particle precipitation and local heating - are investigated self-consistently in the context of hydrodynamics, the problem being treated as an initial boundary-value problem. It is extremely difficult to construct a general model for the line solar activity-magnetosphere-atmosphere; however, a limited model for this link is possible. The paper describes such a model, and presents some results on energy deposition into the earth's atmosphere due to solar activity-generated disturbances. Results from the present calculations are presented and discussed.

  3. Hazardous Waste Certification Plan: Hazardous Waste Handling Facility, Lawrence Berkeley Laboratory

    SciTech Connect

    Not Available

    1992-02-01

    The purpose of this plan is to describe the organization and methodology for the certification of hazardous waste (HW) handled in the Lawrence Berkeley Laboratory (LBL) Hazardous Waste Handling Facility (HWHF). The plan also incorporates the applicable elements of waste reduction, which include both up-front minimization and end- product treatment to reduce the volume and toxicity of the waste; segregation of the waste as it applies to certification; and executive summary of the Quality Assurance Program Plan (QAPP) for the HWHF and a list of the current and planned implementing procedures used in waste certification. The plan provides guidance from the HWHF to waste generators, waste handlers, and the Systems Group Manager to enable them to conduct their activities and carry out their responsibilities in a manner that complies with several requirements of the Federal Resource Conservation and Resource Recovery Act (RCRA), the Federal Department of Transportation (DOT), and the State of California, Code of Regulations (CCR), Title 22.

  4. Lunar Landing Trajectory Design for Onboard Hazard Detection and Avoidance

    NASA Technical Reports Server (NTRS)

    Paschall, Steve; Brady, Tye; Sostaric, Ron

    2009-01-01

    The Autonomous Landing and Hazard Avoidance Technology (ALHAT) Project is developing the software and hardware technology needed to support a safe and precise landing for the next generation of lunar missions. ALHAT provides this capability through terrain-relative navigation measurements to enhance global-scale precision, an onboard hazard detection system to select safe landing locations, and an Autonomous Guidance, Navigation, and Control (AGNC) capability to process these measurements and safely direct the vehicle to a landing location. This paper focuses on the key trajectory design issues relevant to providing an onboard Hazard Detection and Avoidance (HDA) capability for the lander. Hazard detection can be accomplished by the crew visually scanning the terrain through a window, a sensor system imaging the terrain, or some combination of both. For ALHAT, this hazard detection activity is provided by a sensor system, which either augments the crew s perception or entirely replaces the crew in the case of a robotic landing. Detecting hazards influences the trajectory design by requiring the proper perspective, range to the landing site, and sufficient time to view the terrain. Following this, the trajectory design must provide additional time to process this information and make a decision about where to safely land. During the final part of the HDA process, the trajectory design must provide sufficient margin to enable a hazard avoidance maneuver. In order to demonstrate the effects of these constraints on the landing trajectory, a tradespace of trajectory designs was created for the initial ALHAT Design Analysis Cycle (ALDAC-1) and each case evaluated with these HDA constraints active. The ALHAT analysis process, described in this paper, narrows down this tradespace and subsequently better defines the trajectory design needed to support onboard HDA. Future ALDACs will enhance this trajectory design by balancing these issues and others in an overall system

  5. Activation of photodynamic therapy in vitro with Cerenkov luminescence generated from Yttrium-90 (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Hartl, Brad A.; Hirschberg, Henry; Marcu, Laura; Cherry, Simon R.

    2016-03-01

    Translation of photodynamic therapy to the clinical setting has primarily been limited to easily accessible and/or superficial diseases where traditional light delivery can be performed noninvasively. Cerenkov luminescence, as generated from medically relevant radionuclides, has been suggested as a means to deliver light to deeper tissues noninvasively in order to overcome this depth limitation. We report on the use of Cerenkov luminescence generated from Yttrium-90 as a means to active the photodynamic therapy process in monolayer tumor cell cultures. The current study investigates the utility of Cerenkov luminescence for activating both the clinically relevant aminolevulinic acid at 1.0 mM and also the more efficient photosensitizer TPPS2a at 1.2 µM. Cells were incubated with aminolevulinic acid for 6 hours prior to radionuclide addition, as well as additional daily treatments for three days. TPPS2a was delivered as a single treatment with an 18 hour incubation time before radionuclide addition. Experiments were completed for both C6 glioma cells and MDA-MB-231 breast tumor cells. Although aminolevulinic acid proved ineffective for generating a therapeutic effect at any activity for either cell line, TPPS2a produced at least a 20% therapeutic effect at activities ranging from 6 to 60 µCi/well for the C6 cell line. Current results demonstrate that it may be possible to generate a therapeutic effect in vivo using Cerenkov luminescence to activate the photodynamic therapy process with clinically relevant photosensitizers.

  6. 76 FR 55846 - Hazardous Waste Management System: Identification and Listing of Hazardous Waste: Carbon Dioxide...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... Listing of Hazardous Waste: Carbon Dioxide (CO2) Streams in Geologic Sequestration Activities AGENCY...) to conditionally exclude carbon dioxide (CO 2 ) streams that are hazardous from the definition of... Recovery Act (RCRA) to conditionally exclude carbon dioxide (CO 2 ) streams that are hazardous from...

  7. 76 FR 48073 - Hazardous Waste Management System: Identification and Listing of Hazardous Waste: Carbon Dioxide...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... AGENCY 40 CFR Parts 260 and 261 RIN 2050-AG60 Hazardous Waste Management System: Identification and Listing of Hazardous Waste: Carbon Dioxide (CO2) Streams in Geologic Sequestration Activities AGENCY... the Agency) is proposing to revise the regulations for hazardous waste management under the...

  8. Drawing as a Generative Activity and Drawing as a Prognostic Activity

    ERIC Educational Resources Information Center

    Schwamborn, Annett; Mayer, Richard E.; Thillmann, Hubertina; Leopold, Claudia; Leutner, Detlev

    2010-01-01

    In this study, 9th-grade students (N = 196) with a mean age of 14.7 years read a scientific text explaining the chemical process of doing laundry with soap and water and then took 3 tests. Students who were instructed to generate drawings during learning scored higher than students who only read on subsequent tests of transfer (d = 0.91),…

  9. Energy and solid/hazardous waste

    SciTech Connect

    1981-12-01

    This report addresses the past and potential future solid and hazardous waste impacts from energy development, and summarizes the major environmental, legislation applicable to solid and hazardous waste generation and disposal. A glossary of terms and acronyms used to describe and measure solid waste impacts of energy development is included. (PSB)

  10. Instructions and Form for Hazardous Waste Generators, Transporters, and Treatment, Storage and Disposal Facilities to Obtain an EPA Identification Number (EPA Form 8700-12)

    EPA Pesticide Factsheets

    This booklet is designed to help you determine if you are subject to requirements under the Resource Conservation and Recovery Act (RCRA) for notifying the U.S. Environmental Protection Agency (EPA) of your regulated waste activities.

  11. Sensory-induced activation of pattern generators in the absence of supraspinal control.

    PubMed

    Lev-Tov, A; Etlin, A; Blivis, D

    2010-06-01

    Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory-activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back-labeled funicular pathways suggest that the CPGs are activated during SCA stimulation by crossed and uncrossed multifunicular projections of sacral neurons and that activation of short projecting proprioneurons is sufficient for the generation of the rhythm by SCA stimulation. The versatile organization of the pathways involved in the SCA-induced rhythm makes it a potent and durable activator of the CPGs in the absence of descending control from the brain. The significance of our findings and their potential clinical use are discussed.

  12. USGS National Seismic Hazard Maps

    USGS Publications Warehouse

    Frankel, A.D.; Mueller, C.S.; Barnhard, T.P.; Leyendecker, E.V.; Wesson, R.L.; Harmsen, S.C.; Klein, F.W.; Perkins, D.M.; Dickman, N.C.; Hanson, S.L.; Hopper, M.G.

    2000-01-01

    The U.S. Geological Survey (USGS) recently completed new probabilistic seismic hazard maps for the United States, including Alaska and Hawaii. These hazard maps form the basis of the probabilistic component of the design maps used in the 1997 edition of the NEHRP Recommended Provisions for Seismic Regulations for New Buildings and Other Structures, prepared by the Building Seismic Safety Council arid published by FEMA. The hazard maps depict peak horizontal ground acceleration and spectral response at 0.2, 0.3, and 1.0 sec periods, with 10%, 5%, and 2% probabilities of exceedance in 50 years, corresponding to return times of about 500, 1000, and 2500 years, respectively. In this paper we outline the methodology used to construct the hazard maps. There are three basic components to the maps. First, we use spatially smoothed historic seismicity as one portion of the hazard calculation. In this model, we apply the general observation that moderate and large earthquakes tend to occur near areas of previous small or moderate events, with some notable exceptions. Second, we consider large background source zones based on broad geologic criteria to quantify hazard in areas with little or no historic seismicity, but with the potential for generating large events. Third, we include the hazard from specific fault sources. We use about 450 faults in the western United States (WUS) and derive recurrence times from either geologic slip rates or the dating of pre-historic earthquakes from trenching of faults or other paleoseismic methods. Recurrence estimates for large earthquakes in New Madrid and Charleston, South Carolina, were taken from recent paleoliquefaction studies. We used logic trees to incorporate different seismicity models, fault recurrence models, Cascadia great earthquake scenarios, and ground-motion attenuation relations. We present disaggregation plots showing the contribution to hazard at four cities from potential earthquakes with various magnitudes and

  13. Hazard categorization of 105-KE basin debris removal project

    SciTech Connect

    Meichle, R.H.

    1996-01-25

    This supporting document provides the hazard categorization for 105-KE Basin Debris Removal Project activities planned in the K east Basin. All activities are categorized as less than Hazard Category 3.

  14. Toxic hazards of underground excavation

    SciTech Connect

    Smith, R.; Chitnis, V.; Damasian, M.; Lemm, M.; Popplesdorf, N.; Ryan, T.; Saban, C.; Cohen, J.; Smith, C.; Ciminesi, F.

    1982-09-01

    Inadvertent intrusion into natural or man-made toxic or hazardous material deposits as a consequence of activities such as mining, excavation or tunnelling has resulted in numerous deaths and injuries in this country. This study is a preliminary investigation to identify and document instances of such fatal or injurious intrusion. An objective is to provide useful insights and information related to potential hazards due to future intrusion into underground radioactive-waste-disposal facilities. The methodology used in this study includes literature review and correspondence with appropriate government agencies and organizations. Key categories of intrusion hazards are asphyxiation, methane, hydrogen sulfide, silica and asbestos, naturally occurring radionuclides, and various mine or waste dump related hazards.

  15. Earthquake Hazards.

    ERIC Educational Resources Information Center

    Donovan, Neville

    1979-01-01

    Provides a survey and a review of earthquake activity and global tectonics from the advancement of the theory of continental drift to the present. Topics include: an identification of the major seismic regions of the earth, seismic measurement techniques, seismic design criteria for buildings, and the prediction of earthquakes. (BT)

  16. Self-generation of dissipative solitons in magnonic quasicrystal active ring resonator

    NASA Astrophysics Data System (ADS)

    Grishin, S. V.; Beginin, E. N.; Morozova, M. A.; Sharaevskii, Yu. P.; Nikitov, S. A.

    2014-02-01

    Self-generation of dissipative solitons in the magnonic quasicrystal (MQC) active ring resonator is studied theoretically and experimentally. The developed magnonic crystal has quasiperiodic Fibonacci type structure. Frequency selectivity of the MQC together with the parametric three-wave decay of magnetostatic surface spin wave (MSSW) leads to the dissipative soliton self-generation. The transfer matrix method is used to describe MQC transmission responses. Besides, the model of MQC active ring resonator is suggested. The model includes three coupled differential equations describing the parametric decay of MSSW and two differential equations of linear oscillators describing the frequency selectivity of MQC. Numerical simulation results of dissipative soliton self-generation are in a fair agreement with experimental data.

  17. Self-generation of dissipative solitons in magnonic quasicrystal active ring resonator

    SciTech Connect

    Grishin, S. V. Beginin, E. N.; Morozova, M. A.; Sharaevskii, Yu. P.; Nikitov, S. A.

    2014-02-07

    Self-generation of dissipative solitons in the magnonic quasicrystal (MQC) active ring resonator is studied theoretically and experimentally. The developed magnonic crystal has quasiperiodic Fibonacci type structure. Frequency selectivity of the MQC together with the parametric three-wave decay of magnetostatic surface spin wave (MSSW) leads to the dissipative soliton self-generation. The transfer matrix method is used to describe MQC transmission responses. Besides, the model of MQC active ring resonator is suggested. The model includes three coupled differential equations describing the parametric decay of MSSW and two differential equations of linear oscillators describing the frequency selectivity of MQC. Numerical simulation results of dissipative soliton self-generation are in a fair agreement with experimental data.

  18. Recent activities on CCMHD power generation studies with Fuji-1 blow-down facility

    SciTech Connect

    Okuno, Y.; Okamura, T.; Yoshikawa, K.

    1995-12-31

    Recent activities on experimental studies with closed cycle MBD {open_quotes}Fuji-1{open_quotes} blow-down facility at Tokyo Institute of Technology are presented. A new disk generator ( Disk-F4 ) has been installed and a new seed injection system has been introduced from IVTAN (Institute of High Temperature in Russia) in 1994.The design concept of the new generator channel is focused mainly on the reliability of high power generation. The Mach number at the generator inlet and the thermal input are increased up to {approximately}2.8 and {approximately}3.0 MW, respectively. In the new seeding system, a melted seed material is pushed by a piston dozator, instead of gas-pressure-driven in the previous system. The controllability of seed fraction is markedly improved, and the large fluctuation as has been observed previously is diminished, although the spatial non-uniformity of seed fraction which could occur in the all previous experiments is observed. In the power generation experiments with the new components, the maximum power output of 502 kW and the enthalpy extraction ratio of 16.7% have been obtained. These values at the present stage are lower than the maximum values previously achieved in the facility. However, the reliable high power generation can be expected for the new generator.

  19. Developing Students' Listening Metacognitive Strategies Using Online Videotext Self-Dictation-Generation Learning Activity

    ERIC Educational Resources Information Center

    Chang, Ching; Chang, Chih-Kai

    2014-01-01

    The study is based on the use of a flexible learning framework to help students improve information processes underlying strategy instruction in EFL listening. By exploiting the online videotext self-dictation-generation (video-SDG) learning activity implemented on the YouTube caption manager platform, the learning cycle was emphasized to promote…

  20. 7 CFR 1484.38 - Can a Cooperator keep proceeds generated from an activity?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Can a Cooperator keep proceeds generated from an activity? 1484.38 Section 1484.38 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS PROGRAMS TO HELP DEVELOP...

  1. 7 CFR 1484.38 - Can a Cooperator keep proceeds generated from an activity?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Can a Cooperator keep proceeds generated from an activity? 1484.38 Section 1484.38 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS PROGRAMS TO HELP DEVELOP...

  2. 7 CFR 1484.38 - Can a Cooperator keep proceeds generated from an activity?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Can a Cooperator keep proceeds generated from an activity? 1484.38 Section 1484.38 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS PROGRAMS TO HELP DEVELOP...

  3. Identification of intrinsic catalytic activity for electrochemical reduction of water molecules to generate hydrogen.

    PubMed

    Shinagawa, Tatsuya; Takanabe, Kazuhiro

    2015-06-21

    Insufficient hydronium ion activities at near-neutral pH and under unbuffered conditions induce diffusion-limited currents for hydrogen evolution, followed by a reaction with water molecules to generate hydrogen at elevated potentials. The observed constant current behaviors at near neutral pH reflect the intrinsic electrocatalytic reactivity of the metal electrodes for water reduction.

  4. Fast neutron activation analysis by means of low voltage neutron generator

    NASA Astrophysics Data System (ADS)

    Medhat, M. E.

    A description of D-T neutron generator (NG) is presented. This machine can be used for fast neutron activation analysis applied to determine some selected elements, especially light elements, in different materials. Procedure of neutron flux determination and efficiency calculation is described. Examples of testing some Egyptian natural cosmetics are given.

  5. Stability evaluation and correction of a pulsed neutron generator prompt gamma activation analysis system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Source output stability is important for accurate measurement in prompt gamma neutron activation. This is especially true when measuring low-concentration elements such as in vivo nitrogen (~2.5% of body weight). We evaluated the stability of the compact DT neutron generator within an in vivo nitrog...

  6. From convenience to hazard: a short history of the emergence of the menstrual activism movement, 1971-1992.

    PubMed

    Bobel, Chris

    2008-08-01

    In this article, I explore the early history of contemporary menstrual activism in the United States by looking through the lens of the first seven editions of the feminist women's health classic, Our Bodies, Ourselves (OBOS). This analysis illustrates the development of a critical menstrual consciousness as three key phases of the emerging movement, offers a representation of the dynamic nature of feminist health consciousness, and highlights the importance of linking current activism to its past.

  7. Children with autistic spectrum disorders and speech-generating devices: communication in different activities at home.

    PubMed

    Thunberg, Gunilla; Ahlsén, Elisabeth; Sandberg, Annika Dahlgren

    2007-06-01

    The communication of four children with autistic spectrum disorder was investigated when they were supplied with a speech-generating device (SGD) in three different activities in their home environment: mealtime, story reading and "sharing experiences of the preschool day". An activity based communication analysis, in which collective and individual background factors for the activities were outlined, was used as a basis for the discussion of linguistic coding data derived from video-recordings made before and during SGD intervention. The coded communicative behaviours were engagement in activity, role in turn-taking, communicative form, function and effectiveness. An increase in communicative effectiveness was more noticeable when the SGDs could be used to fulfil goals and roles within the activity. The instruction to the parents to use the SGDs in their communication with the child had an important influence on the activities.

  8. Investigating antimicrobial activity in Rheinheimera sp. due to hydrogen peroxide generated by l-lysine oxidase activity.

    PubMed

    Chen, Wen Ming; Lin, Chang Yi; Sheu, Shih Yi

    2010-05-05

    A greenish yellow pigmented bacterial strain, designated GR5, was recently isolated from a freshwater culture pond for a soft-shell turtle. Phylogenetic analyses based on 16S rRNA gene sequences indicate that strain GR5 belongs to the genus Rheinheimera and its only closest neighbor is the type strain of Rheinheimera texasensis (98.2%). Based on the antibiogram assay, strain GR5 possesses a broad spectrum of antimicrobial activity including Gram-positive and Gram-negative bacteria, yeast, algae, and strain GR5 itself. Strain GR5 can synthesize a macromolecule with antimicrobial activity due to the generation of hydrogen peroxide and this antimicrobial effect can be inhibited by catalase. This antimicrobial activity is active only in complex culture media or chemically defined culture media containing l-lysine. This antimicrobial macromolecule in strain GR5 is shown to be a monomeric protein with a molecular mass of 71kDa and isoelectric point of approximately 3.68. Liquid chromatography-tandem mass spectrometry analyses reveal close similarity of a 19-amino acid fragment derived from this protein to the antibacterial protein, AlpP from the marine bacterium Pseudoalteromonas tunicata D2, and to the antibacterial protein, marinocine, from the marine bacterium Marinomonas mediterranea. This study explores the nature of antimicrobial macromolecule such as l-lysine oxidase. This is the first report on a freshwater bacterium producing antimicrobial activity by generating hydrogen peroxide through its enzymatic activity of l-lysine oxidase.

  9. Toxic Hazards Research Unit

    NASA Technical Reports Server (NTRS)

    Macewen, J. D.; Vernot, E. H.

    1971-01-01

    The activities of the Toxic Hazards Research Unit (THRU) for the period of June 1970 through May 1971 reviewed. Modification of the animal exposure facilities primarily for improved human safety but also for experimental integrity and continuity are discussed. Acute toxicity experiments were conducted on hydrogen fluoride (HF), hydrogen chloride (HCl), nitrogen dioxide (NO2), and hydrogen cyanide (HCN) both singly and in combination with carbon dioxide (CO). Additional acute toxicity experiments were conducted on oxygen difluoride (OF2) and chlorine pentafluoride (ClF5). Subacute toxicity studies were conducted on methylisobutylketone and dichloromethane (methylene dichloride). The interim results of further chronic toxicity experiments on monomethylhydrazine (MMH) are also described.

  10. EPA Sets Rules on Hazardous Wastes.

    ERIC Educational Resources Information Center

    Smith, R. Jeffrey

    1980-01-01

    Announces the final rules published by the Environmental Protection Agency requiring that generators, transporters, and disposers of hazardous wastes report exactly where the wastes will be taken. (Author/SA)

  11. A bibliometric analysis of the development of next generation active nanotechnologies

    NASA Astrophysics Data System (ADS)

    Suominen, Arho; Li, Yin; Youtie, Jan; Shapira, Philip

    2016-09-01

    Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990-2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

  12. Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate.

    PubMed

    Stock, Roberto P; Brewer, Jonathan; Wagner, Kerstin; Ramos-Cerrillo, Blanca; Duelund, Lars; Jernshøj, Kit Drescher; Olsen, Lars Folke; Bagatolli, Luis A

    2012-01-01

    The toxicity of Loxosceles spider venom has been attributed to a rare enzyme, sphingomyelinase D, which transforms sphingomyelin to ceramide-1-phosphate. The bases of its inflammatory and dermonecrotic activity, however, remain unclear. In this work the effects of ceramide-1-phosphate on model membranes were studied both by in situ generation of this lipid using a recombinant sphingomyelinase D from the spider Loxosceles laeta and by pre-mixing it with sphingomyelin and cholesterol. The systems of choice were large unilamellar vesicles for bulk studies (enzyme kinetics, fluorescence spectroscopy and dynamic light scattering) and giant unilamellar vesicles for fluorescence microscopy examination using a variety of fluorescent probes. The influence of membrane lateral structure on the kinetics of enzyme activity and the consequences of enzyme activity on the structure of target membranes containing sphingomyelin were examined. The findings indicate that: 1) ceramide-1-phosphate (particularly lauroyl ceramide-1-phosphate) can be incorporated into sphingomyelin bilayers in a concentration-dependent manner and generates coexistence of liquid disordered/solid ordered domains, 2) the activity of sphingomyelinase D is clearly influenced by the supramolecular organization of its substrate in membranes and, 3) in situ ceramide-1-phosphate generation by enzymatic activity profoundly alters the lateral structure and morphology of the target membranes.

  13. Promoting Active Species Generation by Electrochemical Activation in Alkaline Media for Efficient Electrocatalytic Oxygen Evolution in Neutral Media.

    PubMed

    Xu, Kun; Cheng, Han; Liu, Linqi; Lv, Haifeng; Wu, Xiaojun; Wu, Changzheng; Xie, Yi

    2017-01-11

    In this study, by using dicobalt phosphide nanoparticles as precatalysts, we demonstrated that electrochemical activation of metallic precatalysts in alkaline media (comparing with directly electrochemical activation in neutral media) could significantly promote the OER catalysis in neutral media, specifically realizing a 2-fold enhanced activity and meanwhile showing a greatly decreased overpotential of about 100 mV at 10 mA cm(-2). Compared directly with electrochemical activation in neutral media, the electrochemical activation in harsh alkaline media could easily break the strong Co-Co bond and promote active species generation on the surface of metallic Co2P, thus accounting for the enhancement of neutral OER activity, which is also evidenced by HRTEM and the electrochemical double-layer capacitance measurement. The activation of electrochemical oxidation of metallic precatalysts in alkaline media enhanced neutral OER catalysis could also be observed on CoP nanoparticles and Ni2P nanoparticles, suggesting this is a generic strategy. Our work highlights that the activation of electrochemical oxidation of metallic precatalysts in alkaline media would pave new avenues for the design of advanced neutral OER electrocatalysts.

  14. Recognition of human-vehicle interactions in group activities via multi-attributed semantic message generation

    NASA Astrophysics Data System (ADS)

    Elangovan, Vinayak; Shirkhodaie, Amir

    2015-05-01

    Improved Situational awareness is a vital ongoing research effort for the U.S. Homeland Security for the past recent years. Many outdoor anomalous activities involve vehicles as their primary source of transportation to and from the scene where a plot is executed. Analysis of dynamics of Human-Vehicle Interaction (HVI) helps to identify correlated patterns of activities representing potential threats. The objective of this paper is bi-folded. Primarily, we discuss a method for temporal HVI events detection and verification for generation of HVI hypotheses. To effectively recognize HVI events, a Multi-attribute Vehicle Detection and Identification technique (MVDI) for detection and classification of stationary vehicles is presented. Secondly, we describe a method for identification of pertinent anomalous behaviors through analysis of state transitions between two successively detected events. Finally, we present a technique for generation of HVI semantic messages and present our experimental results to demonstrate the effectiveness of semantic messages for discovery of HVI in group activities.

  15. Locomotor-like activity generated by the neonatal mouse spinal cord.

    PubMed

    Bonnot, Agnès; Whelan, Patrick J; Mentis, George Z; O'Donovan, Michael J

    2002-10-01

    This report describes locomotor-like activity generated by the neonatal mouse spinal cord in vitro. We demonstrate that locomotor-like activity can be produced either spontaneously or by a train of stimuli applied to the dorsal roots or in the presence of bath-applied drugs. Calcium imaging of the motoneuron activity generated by a train of dorsal root stimuli revealed a rostrocaudally propagating component of the optical signal in the anterior lumbar (L1-L3) and in the caudal segments (S1-S4). We hypothesize that this spatio-temporal pattern arises from a rostrocaudal gradient of excitability in the relevant segments. Our experiments suggest that left/right reciprocal inhibition and NMDA-mediated oscillations are not essential mechanisms underlying rhythmogenesis in the neonatal mouse cord. Finally, our data are discussed in the context of other models of locomotion in lower and higher vertebrates.

  16. Inhibition of Cholesterol Biosynthesis Reduces γ-Secretase Activity and Amyloid-β Generation.

    PubMed

    Kim, Yoonhee; Kim, Chaeyoung; Jang, Hye Young; Mook-Jung, Inhee

    2016-01-01

    Amyloid-β (Aβ) is one of major molecules contributing to the pathogenesis of Alzheimer's disease (AD). Aβ is derived from amyloid-β protein precursor (AβPP) through sequential cleavages by β- and γ-secretases. Regulation of these components is thought to be an important factor in Aβ generation during the pathogenesis of AD. AβPP, β-secretase, and γ-secretase reside in lipid rafts, where cholesterol regulates the integrity and flexibility of membrane proteins and Aβ is generated. However, the relationship between cholesterol and Aβ generation is controversial. In this study, we aimed to elucidate the direct effects of cholesterol depletion on AβPP processing using AY9944, which blocks the last step of cholesterol biosynthesis and thus minimizes the unknown side effects of upstream inhibitors, such as HMG-CoA reductase inhibitors. Treatment with AY9944 decreased γ-secretase activity and Aβ generation. These results suggested that changes in membrane composition by lowering cholesterol with AY9944 affected γ-secretase activity and Aβ generation, which is associated with AD pathogenesis.

  17. (222)Rn activity in groundwater of the St. Lawrence Lowlands, Quebec, eastern Canada: relation with local geology and health hazard.

    PubMed

    Pinti, Daniele L; Retailleau, Sophie; Barnetche, Diogo; Moreira, Floriane; Moritz, Anja M; Larocque, Marie; Gélinas, Yves; Lefebvre, René; Hélie, Jean-François; Valadez, Arisai

    2014-10-01

    One hundred ninety-eight groundwater wells were sampled to measure the (222)Rn activity in the region between Montreal and Quebec City, eastern Canada. The aim of this study was to relate the spatial distribution of (222)Rn activity to the geology and the hydrogeology of the study area and to estimate the potential health risks associated with (222)Rn in the most populated area of the Province of Quebec. Most of the groundwater samples show low (222)Rn activities with a median value of 8.6 Bq/L. Ninety percent of samples show (222)Rn activity lower than 100 Bq/L, the exposure limit in groundwater recommended by the World Health Organization. A few higher (222)Rn activities (up to 310 Bq/L) have been measured in wells from the Appalachian Mountains and from the magmatic intrusion of Mont-Saint-Hilaire, known for its high level of indoor radon. The spatial distribution of (222)Rn activity seems to be related mainly to lithology differences between U-richer metasediments of the Appalachian Mountains and magmatic intrusions and the carbonaceous silty shales of the St. Lawrence Platform. Radon is slightly enriched in sodium-chlorine waters that evolved at contact with clay-rich formations. (226)Ra, the parent element of (222)Rn could be easily adsorbed on clays, creating a favorable environment for the production and release of (222)Rn into groundwater. The contribution of groundwater radon to indoor radon or by ingestion is minimal except for specific areas near Mont-Saint-Hilaire or in the Appalachian Mountains where this contribution could reach 45% of the total radioactive annual dose.

  18. Pattern-dependent Role of NMDA receptors in Action Potential Generation: Consequences on ERK Activation

    PubMed Central

    Zhao, Meilan; Adams, J. Paige

    2005-01-01

    Synaptic long-term potentiation is maintained through gene transcription, but how the nucleus is recruited remains controversial. Activation of extracellular-signal regulated kinases 1 and 2 (ERKs) with synaptic stimulation has been shown to require NMDA receptors (NMDARs), yet stimulation intensities sufficient to recruit action potentials (APs) also appear to be required. This has led us to ask the question whether NMDARs are necessary for AP generation as they relate to ERK activation. To test this, we examined the effects of NMDAR blockade on APs induced with synaptic stimulation using whole-cell current clamp recordings from CA1 pyramidal cells in hippocampal slices. NMDAR antagonists were found to potently inhibit APs generated with 5 and 100 Hz synaptic stimulation. Blockade of APs, and ERK activation, could be overcome with the addition of the GABA-A antagonist bicuculline, indicating that APs are sufficient to activate signals such as ERK in the nucleus and throughout the neuron in the continued presence of NMDAR antagonists. Interestingly, no effects of the NMDAR antagonists were observed when theta-burst stimulation (TBS) was used. This resistance to the antagonists is conferred by temporal summation during the bursts. These results clarify findings from a previous study showing that ERK activation induced with TBS is resistant to APV, in contrast to that induced with 5 Hz or 100 Hz stimulation, which is sensitive. By showing that NMDAR blockade inhibits AP generation, we demonstrate that a major role NMDARs play in cell-wide and nuclear ERK activation is through their contribution to action potential generation. PMID:16049179

  19. Hazard function theory for nonstationary natural hazards

    NASA Astrophysics Data System (ADS)

    Read, L.; Vogel, R. M.

    2015-12-01

    Studies from the natural hazards literature indicate that many natural processes, including wind speeds, landslides, wildfires, precipitation, streamflow and earthquakes, show evidence of nonstationary behavior such as trends in magnitudes through time. Traditional probabilistic analysis of natural hazards based on partial duration series (PDS) generally assumes stationarity in the magnitudes and arrivals of events, i.e. that the probability of exceedance is constant through time. Given evidence of trends and the consequent expected growth in devastating impacts from natural hazards across the world, new methods are needed to characterize their probabilistic behavior. The field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (x) with its failure time series (t), enabling computation of corresponding average return periods and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose PDS magnitudes are assumed to follow the widely applied Poisson-GP model. We derive a 2-parameter Generalized Pareto hazard model and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. Our theoretical analysis linking hazard event series x, with corresponding failure time series t, should have application to a wide class of natural hazards.

  20. Generation of field potentials and modulation of their dynamics through volume integration of cortical activity.

    PubMed

    Kajikawa, Yoshinao; Schroeder, Charles E

    2015-01-01

    Field potentials (FPs) recorded within the brain, often called "local field potentials" (LFPs), are useful measures of net synaptic activity in a neuronal ensemble. However, due to volume conduction, FPs spread beyond regions of underlying synaptic activity, and thus an "LFP" signal may not accurately reflect the temporal patterns of synaptic activity in the immediately surrounding neuron population. To better understand the physiological processes reflected in FPs, we explored the relationship between the FP and its membrane current generators using current source density (CSD) analysis in conjunction with a volume conductor model. The model provides a quantitative description of the spatiotemporal summation of immediate local and more distant membrane currents to produce the FP. By applying the model to FPs in the macaque auditory cortex, we have investigated a critical issue that has broad implications for FP research. We have shown that FP responses in particular cortical layers are differentially susceptible to activity in other layers. Activity in the supragranular layers has the strongest contribution to FPs in other cortical layers, and infragranular FPs are most susceptible to contributions from other layers. To define the physiological processes generating FPs recorded in loci of relatively weak synaptic activity, strong effects produced by synaptic events in the vicinity have to be taken into account. While outlining limitations and caveats inherent to FP measurements, our results also suggest specific peak and frequency band components of FPs can be related to activity in specific cortical layers. These results may help improving the interpretability of FPs.

  1. Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation

    PubMed Central

    Stopa, Jack D.; Neuberg, Donna; Puligandla, Maneka; Furie, Bruce; Zwicker, Jeffrey I.

    2017-01-01

    BACKGROUND: Protein disulfide isomerase (PDI) is required for thrombus formation. We previously demonstrated that glycosylated quercetin flavonoids such as isoquercetin inhibit PDI activity and thrombus formation in animal models, but whether extracellular PDI represents a viable anticoagulant target in humans and how its inhibition affects blood coagulation remain unknown. METHODS: We evaluated effects of oral administration of isoquercetin on platelet-dependent thrombin generation in healthy subjects and patients with persistently elevated anti-phospholipid antibodies. RESULTS: Following oral administration of 1,000 mg isoquercetin to healthy adults, the measured peak plasma quercetin concentration (9.2 μM) exceeded its IC50 for inhibition of PDI by isoquercetin in vitro (2.5 ± 0.4 μM). Platelet-dependent thrombin generation decreased by 51% in the healthy volunteers compared with baseline (P = 0.0004) and by 64% in the anti-phospholipid antibody cohort (P = 0.015) following isoquercetin ingestion. To understand how PDI affects thrombin generation, we evaluated substrates of PDI identified using an unbiased mechanistic-based substrate trapping approach. These studies identified platelet factor V as a PDI substrate. Isoquercetin blocked both platelet factor Va and thrombin generation with an IC50 of ~5 μM. Inhibition of PDI by isoquercetin ingestion resulted in a 53% decrease in the generation of platelet factor Va (P = 0.001). Isoquercetin-mediated inhibition was reversed with addition of exogenous factor Va. CONCLUSION: These studies show that oral administration of isoquercetin inhibits PDI activity in plasma and diminishes platelet-dependent thrombin generation predominantly by blocking the generation of platelet factor Va. These pharmacodynamic and mechanistic observations represent an important step in the development of a novel class of antithrombotic agents targeting PDI. TRIAL REGISTRATION: Clinicaltrials.gov (NCT01722669) FUNDING: National Heart

  2. Immigrant generation and physical activity among Mexican, Chinese & Filipino adults in the U.S.

    PubMed

    Afable-Munsuz, Aimee; Ponce, Ninez A; Rodriguez, Michael; Perez-Stable, Eliseo J

    2010-06-01

    Migrant studies of physical activity (PA) can provide insight into the prevention of chronic disease. It is unclear, however, whether PA increases or decreases the longer migrants live in their host country. In the US, studies on immigrants' length of residence in the US and PA are inconclusive and many studies do not adequately consider the role of socioeconomic status (SES). Using California data, we examine relationships between immigrant generation and physical activity (PA) among Mexican, Chinese and Filipino adults, who represent the three largest immigrant groups in the US, and the extent to which the relationships are confounded by SES. Data from the 2000 US Census was linked with data on adults 18 years and older from the 2005 California Health Interview Survey. PA was measured in three different domains: leisure time (LTPA), non-leisure time (NLTPA) and any PA. Logistic regression was used to examine whether a wide range of SES factors, measured at the respondent and neighborhood levels, influenced the relationship between immigrant generation and PA in all domains and in different ethnic origin groups. Generation was significantly associated with LTPA among Mexican and Chinese adults and with NLTPA among all 3 ethnic origin groups; however the nature of the relationships varied. After adjusting for individual and neighborhood SES factors, a positive association between generation and LTPA remained among Mexican adults, and negative association between generation and NLTPA remained among Chinese and Filipino adults. These results underscore the importance of comparative studies of immigrant generation and PA and consideration of SES factors to identify pathways linking generation to PA. In the context of increasing rates of chronic disease, the study of transitions in PA among immigrants will continue to be critical to promoting the public health of diverse populations in countries such as the US.

  3. Schoolyard Volcanoes: A Unit in Volcanology and Hazards

    NASA Astrophysics Data System (ADS)

    Lechner, H. N.; Gochis, E. E.; Brill, K. A.

    2014-12-01

    How do you teach volcanology and volcanic hazards to students when there is no volcano nearby? You bring the volcano to them! At Michigan Technological University we have developed a four-lesson-unit for middle and high school students which incorporates virtual, analogue and numerical models to increase students' interests in geosciences while simultaneously expanding the community of earth-science-literate individuals necessary for a disaster resilient society. The unit aims to build on students' prior geoscience knowledge by examining the physical properties that influence volcanic eruptions and introduces them to challenges and methods of communicating hazards and risk. Lesson one engages students in a series of hands-on investigations that explore the "3-Vs" of volcanology: Viscosity, Volatiles and Volume. The students learn about the relationship between magma composition and viscosity and the influence on eruption style, behavior and morphology of different volcanoes. Lesson two uses an analogue model of a volcano to demonstrate the forces involved in an explosive eruption and associated hazards. Students think critically about the factors that affect hazards and risk as well as the variables (such as topography) that affect the eruption and the hazard. During lesson three students use Google Earth for a virtual field trip to Pacaya volcano, Guatemala to examine changes in the landscape over time and other evidence of volcanic activity to make interpretations about the volcano. The final lesson has the students use numerical models and GIS to create hazard maps based on probabilistic lahar scenarios. Throughout the unit students are engaged in an inquiry-based exploration that covers several Next Generation Science Standards (NGSS) content and practices. This four lesson unit has been field tested in two school districts and during a summer engineering program. Results from student work and post-surveys show that this strategy raises interests in and

  4. Rostral anterior cingulate activity generates posterior versus anterior theta activity linked to agentic extraversion.

    PubMed

    Chavanon, Mira-Lynn; Wacker, Jan; Stemmler, Gerhard

    2011-06-01

    Recent research using the resting electroencephalogram (EEG) showed that posterior versus anterior theta activity (around 4-8 Hz) is consistently associated with agency, reflecting the dopaminergic core of extraversion (i.e., incentive motivation, positive emotion). Neuroimaging studies using various methodologies and experimental paradigms have converged on the anterior cingulate cortex (ACC) as a neurophysiological correlate of extraversion. The aim of the present study is integrate these lines of research by testing the hypothesis that posterior versus anterior EEG theta is at least partly based on ACC theta activity. Resting EEG data were analyzed in N = 78 healthy, male participants extremely high or low in agentic extraversion (aE). Using the low-resolution electromagnetic tomography algorithm, we localized the sources of aE-dependent intracerebral theta activity within rostral subdivisions of the ACC. The posterior versus anterior index and theta current density within the rostral ACC were significantly correlated (r = -.52), and both displayed high retest stability across 5 hr and were associated with traits from the aE spectrum. These neurophysiological correlates of aE and their possible functional significance are discussed.

  5. Active power control of solar PV generation for large interconnection frequency regulation and oscillation damping

    DOE PAGES

    Liu, Yong; Zhu, Lin; Zhan, Lingwei; ...

    2015-06-23

    Because of zero greenhouse gas emission and decreased manufacture cost, solar photovoltaic (PV) generation is expected to account for a significant portion of future power grid generation portfolio. Because it is indirectly connected to the power grid via power electronic devices, solar PV generation system is fully decoupled from the power grid, which will influence the interconnected power grid dynamic characteristics as a result. In this study, the impact of solar PV penetration on large interconnected power system frequency response and inter-area oscillation is evaluated, taking the United States Eastern Interconnection (EI) as an example. Furthermore, based on the constructedmore » solar PV electrical control model with additional active power control loops, the potential contributions of solar PV generation to power system frequency regulation and oscillation damping are examined. The advantages of solar PV frequency support over that of wind generator are also discussed. Finally, simulation results demonstrate that solar PV generations can effectively work as ‘actuators’ in alleviating the negative impacts they bring about.« less

  6. Active power control of solar PV generation for large interconnection frequency regulation and oscillation damping

    SciTech Connect

    Liu, Yong; Zhu, Lin; Zhan, Lingwei; Gracia, Jose R.; King, Thomas Jr.; Liu, Yilu

    2015-06-23

    Because of zero greenhouse gas emission and decreased manufacture cost, solar photovoltaic (PV) generation is expected to account for a significant portion of future power grid generation portfolio. Because it is indirectly connected to the power grid via power electronic devices, solar PV generation system is fully decoupled from the power grid, which will influence the interconnected power grid dynamic characteristics as a result. In this study, the impact of solar PV penetration on large interconnected power system frequency response and inter-area oscillation is evaluated, taking the United States Eastern Interconnection (EI) as an example. Furthermore, based on the constructed solar PV electrical control model with additional active power control loops, the potential contributions of solar PV generation to power system frequency regulation and oscillation damping are examined. The advantages of solar PV frequency support over that of wind generator are also discussed. Finally, simulation results demonstrate that solar PV generations can effectively work as ‘actuators’ in alleviating the negative impacts they bring about.

  7. Hydro-meteorological hazards associated with extreme precipitation events in a geomorphological-active area of Europe: Vrancea-Buzau Seismic Region

    NASA Astrophysics Data System (ADS)

    Dragota, C.; Micu, D.; Zarea, R.; Micu, M.

    2012-04-01

    When a high incidence of hydro-meteorological hazards characterizes a region where its coping capacity is poorly developed, the elements at risk vulnerability may notable increase. This is the case of Vrancea-Buzau Seismic Region, located in the Curvature Carpathians and Subcarpathians of Romania. This region is one of Europe's most landslide-prone areas, which also experiences propitious conditions for flash-floods, and is at the same time, the most active cub-crustal province of Europe. This paper aims at presenting the meteorological framework of heavy rain events occurrence, highlighting their role in the region's hydrology and geomorphology. The paper outlines some typical synoptic conditions favourable for triggering severe flash-flood and multiple-landslides events (e.g. Mediterranean fronts, retrograde Cyclones or trans-Carpathian air mass advections). By selecting several case studies (i.e. 1975 and 2005, considered the wettest years from the observational data in the region), characterizing both the Carpathian mountains and the Subcarpathian hills and depressions, a preliminary inventory of damages caused by such processes was undertaken, as a basis for a future vulnerability assessment in the region. The presence of numerous elements at risk (e.g. a dense and sometimes continuous network of villages or scattered households) overlaps one of Europe's most reduced income/family areas. Consequently, an increase of the potential losses value was observed in the last decades due to heavy rain episodes. The paper offers important results for the assessment of the flash-flood and landslide hazard at regional level (FP7 MC-ITN CHANGES Project), as a necessary input for the local strategies of risk reduction, by determining the potential recurrence intervals for certain thresholds of one of the most important triggering factors such as precipitation.

  8. Design and Activation of a LOX/GH Chemical Steam Generator

    NASA Technical Reports Server (NTRS)

    Saunders, G. P.; Mulkey, C. A.; Taylor, S. A.

    2009-01-01

    The purpose of this paper is to give a detailed description of the design and activation of the LOX/GH fueled chemical steam generator installed in Cell 2 of the E3 test facility at Stennis Space Center, MS (SSC). The steam generator uses a liquid oxygen oxidizer with gaseous hydrogen fuel. The combustion products are then quenched with water to create steam at pressures from 150 to 450 psig at temperatures from 350 to 750 deg F (from saturation to piping temperature limits).

  9. Hazardous waste management in Chilean main industry: an overview.

    PubMed

    Navia, Rodrigo; Bezama, Alberto

    2008-10-01

    The new "Hazardous Waste Management Regulation" was published in the Official Newspaper of the Chilean Republic on 12 June 2003, being in force 365 days after its publication (i.e., 12 June 2004). During the next 180 days after its publication (i.e., until 12 December 2004), each industrial facility was obligated to present a "Hazardous Waste Management Plan" if the facility generates more than 12 ton/year hazardous wastes or more than 12 kg/year acute toxic wastes. Based on the Chilean industrial figures and this new regulation, hazardous waste management plans were carried out in three facilities of the most important sectors of Chilean industrial activity: a paper production plant, a Zn and Pb mine and a sawmill and wood remanufacturing facility. Hazardous wastes were identified, classified and quantified in all facilities. Used oil and oil-contaminated materials were determined to be the most important hazardous wastes generated. Minimization measures were implemented and re-use and recycling options were analyzed. The use of used oil as alternative fuel in high energy demanding facilities (i.e., cement facilities) and the re-refining of the used oil were found to be the most suitable options. In the Zn and Pb mine facility, the most important measure was the beginning of the study for using spent oils as raw material for the production of the explosives used for metals recovery from the rock. In Chile, there are three facilities producing alternative fuels from used oil, while two plants are nowadays re-refining oil to recycle it as hydraulic fluid in industry. In this sense, a proper and sustainable management of the used oil appears to be promissory.

  10. Active Oxygen Generator by Silent Discharge and Oxidation Power in Formation of Oxide Thin Films

    NASA Astrophysics Data System (ADS)

    Tanaka, Masaaki; Kawagoe, Yasuyuki; Tsukazaki, Hisashi; Yamanishi, Kenichiro

    We have studied the low pressure silent discharge type active oxygen generator in terms of the application to the formation of oxide thin films. In this paper the oxidation power of active oxygen in the oxide thin film formation is compared with that of oxygen and ozone by forming silicon oxide thin films. It was confirmed that the oxidation power is in turn of active oxygen > ozone > oxygen from the experimental result of the number of x in SiOx thin film. Furthermore we applied active oxygen to the formation of the thin film high temperature super conductor and active oxygen was found to be effective to the formation of the thin film with high performance.

  11. Auditory evoked fields to vocalization during passive listening and active generation in adults who stutter.

    PubMed

    Beal, Deryk S; Cheyne, Douglas O; Gracco, Vincent L; Quraan, Maher A; Taylor, Margot J; De Nil, Luc F

    2010-10-01

    We used magnetoencephalography to investigate auditory evoked responses to speech vocalizations and non-speech tones in adults who do and do not stutter. Neuromagnetic field patterns were recorded as participants listened to a 1 kHz tone, playback of their own productions of the vowel /i/ and vowel-initial words, and actively generated the vowel /i/ and vowel-initial words. Activation of the auditory cortex at approximately 50 and 100 ms was observed during all tasks. A reduction in the peak amplitudes of the M50 and M100 components was observed during the active generation versus passive listening tasks dependent on the stimuli. Adults who stutter did not differ in the amount of speech-induced auditory suppression relative to fluent speakers. Adults who stutter had shorter M100 latencies for the actively generated speaking tasks in the right hemisphere relative to the left hemisphere but the fluent speakers showed similar latencies across hemispheres. During passive listening tasks, adults who stutter had longer M50 and M100 latencies than fluent speakers. The results suggest that there are timing, rather than amplitude, differences in auditory processing during speech in adults who stutter and are discussed in relation to hypotheses of auditory-motor integration breakdown in stuttering.

  12. Indomethacin augments lymphokine-activated killer cell generation by patients with malignant mesothelioma

    SciTech Connect

    Manning, L.S.; Bowman, R.V.; Davis, M.R.; Musk, A.W.; Robinson, B.W. )

    1989-10-01

    Human malignant mesothelioma (MM) cells are resistant to natural killer (NK) cell lysis but susceptible to lysis by lymphokine-activated killer (LAK) cells from control individuals. The present study was performed to determine the capacity of patients with MM (n = 22) and individuals occupationally exposed to asbestos (the major population at risk of developing this disease, n = 52) to generate LAK cells capable of effectively lysing human mesothelioma cells. Compared to controls (n = 20), both patient groups demonstrated significantly depressed LAK cell activity against mesothelioma tumor cell targets (55 +/- 3% lysis by controls vs 34 +/- 3% lysis by patients with MM, P less than 0.005; and 45 +/- 3% lysis by asbestos-exposed individuals, P less than 0.025). Addition of 10 micrograms/ml indomethacin during LAK cell generation restored normal LAK cell activity for patients with MM (52 +/- 6% lysis of cultured human MM cells, P = NS compared to controls), suggesting that the defective cytolytic cell function observed in some patients with MM is a result of prostaglandin-induced immunosuppression. The ability of indomethacin to restore suppressed LAK cell activity in patients with MM suggests that the concomitant use of this agent in ex vivo LAK cell generation and in patients undergoing interleukin/LAK cell therapy may be beneficial.

  13. Hazardous waste operational plan for site 300

    SciTech Connect

    Roberts, R.S.

    1982-02-12

    This plan outlines the procedures and operations used at LLNL's Site 300 for the management of the hazardous waste generated. This waste consists primarily of depleted uranium (a by-product of U-235 enrichment), beryllium, small quantities of analytical chemicals, industrial type waste such as solvents, cleaning acids, photographic chemicals, etc., and explosives. This plan details the operations generating this waste, the proper handling of this material and the procedures used to treat or dispose of the hazardous waste. A considerable amount of information found in this plan was extracted from the Site 300 Safety and Operational Manual written by Site 300 Facility personnel and the Hazards Control Department.

  14. Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood

    PubMed Central

    Chatterjee, Manash S.; Denney, William S.; Jing, Huiyan; Diamond, Scott L.

    2010-01-01

    Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time (Ti) of 1 to 2 hours (depending on donor), while activation of platelets with the GPVI-activator convulxin reduces Ti to ∼20 minutes. Since current kinetic models fail to generate thrombin in the absence of added TF, we implemented a Platelet-Plasma ODE model accounting for: the Hockin-Mann protease reaction network, thrombin-dependent display of platelet phosphatidylserine, VIIa function on activated platelets, XIIa and XIa generation and function, competitive thrombin substrates (fluorogenic detector and fibrinogen), and thrombin consumption during fibrin polymerization. The kinetic model consisting of 76 ordinary differential equations (76 species, 57 reactions, 105 kinetic parameters) predicted the clotting of resting and convulxin-activated human blood as well as predicted Ti of human blood under 50 different initial conditions that titrated increasing levels of TF, Xa, Va, XIa, IXa, and VIIa. Experiments with combined anti-XI and anti-XII antibodies prevented thrombin production, demonstrating that a leak of XIIa past saturating amounts of CTI (and not “blood-borne TF” alone) was responsible for in vitro initiation without added TF. Clotting was not blocked by antibodies used individually against TF, VII/VIIa, P-selectin, GPIb, protein disulfide isomerase, cathepsin G, nor blocked by the ribosome inhibitor puromycin, the Clk1 kinase inhibitor Tg003, or inhibited VIIa (VIIai). This is the first model to predict the observed behavior of CTI-treated human blood, either resting or stimulated with platelet activators. CTI-treated human blood will clot in vitro due to the combined activity of XIIa and XIa, a process enhanced by platelet activators and which proceeds in the

  15. 40 CFR 262.11 - Hazardous waste determination.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.11 Hazardous waste... waste in subpart D of 40 CFR part 261. Note: Even if the waste is listed, the generator still has an... the waste is not listed in subpart D of 40 CFR part 261, the generator must then determine whether...

  16. 40 CFR 262.11 - Hazardous waste determination.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.11 Hazardous waste... waste in subpart D of 40 CFR part 261. Note: Even if the waste is listed, the generator still has an... the waste is not listed in subpart D of 40 CFR part 261, the generator must then determine whether...

  17. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60 Imports... except that: (1) In place of the generator's name, address and EPA identification number, the name and address of the foreign generator and the importer's name, address and EPA identification number must...

  18. 40 CFR 262.11 - Hazardous waste determination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.11 Hazardous waste... waste in subpart D of 40 CFR part 261. Note: Even if the waste is listed, the generator still has an... the waste is not listed in subpart D of 40 CFR part 261, the generator must then determine whether...

  19. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60 Imports... except that: (1) In place of the generator's name, address and EPA identification number, the name and address of the foreign generator and the importer's name, address and EPA identification number must...

  20. 40 CFR 262.11 - Hazardous waste determination.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.11 Hazardous waste... waste in subpart D of 40 CFR part 261. Note: Even if the waste is listed, the generator still has an... the waste is not listed in subpart D of 40 CFR part 261, the generator must then determine whether...

  1. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60 Imports... except that: (1) In place of the generator's name, address and EPA identification number, the name and address of the foreign generator and the importer's name, address and EPA identification number must...

  2. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60 Imports... except that: (1) In place of the generator's name, address and EPA identification number, the name and address of the foreign generator and the importer's name, address and EPA identification number must...

  3. 40 CFR 262.11 - Hazardous waste determination.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE General § 262.11 Hazardous waste... waste in subpart D of 40 CFR part 261. Note: Even if the waste is listed, the generator still has an... the waste is not listed in subpart D of 40 CFR part 261, the generator must then determine whether...

  4. Volcanic-ash hazard to aviation during the 2003-2004 eruptive activity of Anatahan volcano, Commonwealth of the Northern Mariana Islands

    USGS Publications Warehouse

    Guffanti, M.; Ewert, J.W.; Gallina, G.M.; Bluth, G.J.S.; Swanson, G.L.

    2005-01-01

    Within the Commonwealth of the Northern Mariana Islands (CNMI), Anatahan is one of nine active subaerial volcanoes that pose hazards to major air-traffic routes from airborne volcanic ash. The 2003-2004 eruptive activity of Anatahan volcano affected the region's aviation operations for 3 days in May 2003. On the first day of the eruption (10 May 2003), two international flights from Saipan to Japan were cancelled, and several flights implemented ash-avoidance procedures. On 13 May 2003, a high-altitude flight through volcanic gas was reported, with no perceptible damage to the aircraft. TOMS and MODIS analysis of satellite data strongly suggests that no significant ash and only minor amounts of SO2 were involved in the incident, consistent with crew observations. On 23 May 2003, airport operations were disrupted when tropical-cyclone winds dispersed ash to the south, dusting Saipan with light ashfall and causing flight cancellations there and at Guam 320 km south of the volcano. Operational (near-real-time) monitoring of ash clouds produced by Anatahan has been conducted since the first day of the eruption on 10 May 2003 by the Washington Volcanic Ash Advisory Center (VAAC). The VAAC was among the first groups outside of the immediate area of the volcano to detect and report on the unexpected eruption of Anatahan. After being contacted about an unusual cloud by National Weather Service forecasters in Guam at 1235 UTC on 10 May 2003, the VAAC analyzed GOES 9 images, confirming Anatahan as the likely source of an ash cloud and estimating that the eruption began at about 0730 UTC. The VAAC issued its first Volcanic Ash Advisory for Anatahan at 1300 UTC on 10 May 2003 more than 5 h after the start of the eruption, the delay reflecting the difficulty of detecting and confirming a surprise eruption at a remote volcano with no in situ real-time geophysical monitoring. The initial eruption plume reached 10.7-13.4 km (35,000-44,000 ft), well into jet cruise altitudes

  5. Volcanic-ash hazard to aviation during the 2003 2004 eruptive activity of Anatahan volcano, Commonwealth of the Northern Mariana Islands

    NASA Astrophysics Data System (ADS)

    Guffanti, Marianne; Ewert, John W.; Gallina, Gregory M.; Bluth, Gregg J. S.; Swanson, Grace L.

    2005-08-01

    Within the Commonwealth of the Northern Mariana Islands (CNMI), Anatahan is one of nine active subaerial volcanoes that pose hazards to major air-traffic routes from airborne volcanic ash. The 2003-2004 eruptive activity of Anatahan volcano affected the region's aviation operations for 3 days in May 2003. On the first day of the eruption (10 May 2003), two international flights from Saipan to Japan were cancelled, and several flights implemented ash-avoidance procedures. On 13 May 2003, a high-altitude flight through volcanic gas was reported, with no perceptible damage to the aircraft. TOMS and MODIS analysis of satellite data strongly suggests that no significant ash and only minor amounts of SO 2 were involved in the incident, consistent with crew observations. On 23 May 2003, airport operations were disrupted when tropical-cyclone winds dispersed ash to the south, dusting Saipan with light ashfall and causing flight cancellations there and at Guam 320 km south of the volcano. Operational (near-real-time) monitoring of ash clouds produced by Anatahan has been conducted since the first day of the eruption on 10 May 2003 by the Washington Volcanic Ash Advisory Center (VAAC). The VAAC was among the first groups outside of the immediate area of the volcano to detect and report on the unexpected eruption of Anatahan. After being contacted about an unusual cloud by National Weather Service forecasters in Guam at 1235 UTC on 10 May 2003, the VAAC analyzed GOES 9 images, confirming Anatahan as the likely source of an ash cloud and estimating that the eruption began at about 0730 UTC. The VAAC issued its first Volcanic Ash Advisory for Anatahan at 1300 UTC on 10 May 2003 more than 5 h after the start of the eruption, the delay reflecting the difficulty of detecting and confirming a surprise eruption at a remote volcano with no in situ real-time geophysical monitoring. The initial eruption plume reached 10.7-13.4 km (35,000-44,000 ft), well into jet cruise altitudes

  6. Hazard evaluation for 244-AR vault facility

    SciTech Connect

    BRAUN, D.J.

    1999-08-25

    This document presents the results of a hazard identification and evaluation performed on the 244-AR Vault Facility to close a USQ (USQ No.TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed In HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities. A hazard evaluation for the Hanford Site 244-AR Vault Facility was performed. The process and results of the hazard evaluation are provided in this document. A previous hazard evaluation was performed for the 244-AR Vault Facility in 1996 in support of the Basis for Interim Operation (BIO) (HNF-SD-WM-BIO-001, 1998, Revision 1) of the Tank Waste Remediation System (TWRS). The results of that evaluation are provided in the BIO. Upon review of those results it was determined that hazardous conditions that could lead to the release of radiological and toxicological material from the 244-AR vaults due to flooding was not addressed in the original hazards evaluation. This supplemental hazard evaluation addresses this oversight of the original hazard evaluation. The results of the hazard evaluation were compared to the current TWRS BIO to identify any hazardous conditions where Authorization Basis (AB) controls may not be sufficient or may not exist. This document is not part of the AB and is not a vehicle for requesting changes to the AB. It is only intended to provide information about hazardous conditions associated with the condition and configuration of the 244-AR vault facility. The AB Control Decision process could be used to determine the applicability and adequacy of existing AB controls as well as any new controls that may be needed for the identified hazardous conditions associated with 244-AR vault flooding. This hazard evaluation does not constitute an accident analysis.

  7. Recovery of rhythmic activity in a central pattern generator: analysis of the role of neuromodulator and activity-dependent mechanisms

    PubMed Central

    Zhang, Yili; Golowasch, Jorge

    2015-01-01

    The pyloric network of decapods crustaceans can undergo dramatic rhythmic activity changes. Under normal conditions the network generates low frequency rhythmic activity that depends obligatorily on the presence of neuromodulatory input from the central nervous system. When this input is removed (decentralization) the rhythmic activity ceases. In the continued absence of this input, periodic activity resumes after a few hours in the form of episodic bursting across the entire network that later turns into stable rhythmic activity that is nearly indistinguishable from control (recovery). It has been proposed that an activity-dependent modification of ionic conductance levels in the pyloric pacemaker neuron drives the process of recovery of activity. Previous modeling attempts have captured some aspects of the temporal changes observed experimentally, but key features could not be reproduced. Here we examined a model in which slow activity-dependent regulation of ionic conductances and slower neuromodulator-dependent regulation of intracellular Ca2+ concentration reproduce all the temporal features of this recovery. Key aspects of these two regulatory mechanisms are their independence and their different kinetics. We also examined the role of variability (noise) in the activity-dependent regulation pathway and observe that it can help to reduce unrealistic constraints that were otherwise required on the neuromodulator-dependent pathway. We conclude that small variations in intracellular Ca2+ concentration, a Ca2+ uptake regulation mechanism that is directly targeted by neuromodulator-activated signaling pathways, and variability in the Ca2+ concentration sensing signaling pathway can account for the observed changes in neuronal activity. Our conclusions are all amenable to experimental analysis. PMID:21573963

  8. A flexible active and reactive power control strategy for a variable speed constant frequency generating system

    SciTech Connect

    Tang, Y.; Xu, L.

    1995-07-01

    Variable-speed constant-frequency generating systems are used in wind power, hydro power, aerospace, and naval power generations to enhance efficiency and reduce friction. In these applications, an attractive candidate is the slip power recovery system comprising of doubly excited induction machine or doubly excited brushless reluctance machine and PWM converters with a dc link. In this paper, a flexible active and reactive power control strategy is developed, such that the optimal torque-speed profile of the turbine can be followed and overall reactive power can be controlled, while the machine copper losses have been minimized. At the same time, harmonics injected into the power network has also been minimized. In this manner, the system can function as both a high-efficient power generator and a flexible reactive power compensator.

  9. The Hazard Notification System (HANS)

    NASA Astrophysics Data System (ADS)

    Snedigar, S. F.; Venezky, D. Y.

    2009-12-01

    The Volcano Hazards Program (VHP) has developed a Hazard Notification System (HANS) for distributing volcanic activity information collected by scientists to airlines, emergency services, and the general public. In the past year, data from HANS have been used by airlines to make decisions about diverting or canceling flights during the eruption of Mount Redoubt. HANS was developed to provide a single system that each of the five U.S. volcano observatories could use for communicating and storing volcanic information about the 160+ potentially active U.S. volcanoes. The data that cover ten tables and nearly 100 fields are now stored in similar formats, and the information can be released in styles requested by our agency partners, such as the International Civil Aviation Organization (ICAO). Currently, HANS has about 4500 reports stored; on average, two - three reports are added daily. HANS (at its most basic form) consists of a user interface for entering data into one of many release types (Daily Status Reports, Weekly Updates, Volcano Activity Notifications, etc.); a database holding previous releases as well as observatory information such as email address lists and volcano boilerplates; and a transmission system for formatting releases and sending them out by email or other web related system. The user interface to HANS is completely web based, providing access to our observatory scientists from any online PC. The underlying database stores the observatory information and drives the observatory and program websites' dynamic updates and archived information releases. HANS also runs scripts for generating several different feeds including the program home page Volcano Status Map. Each observatory has the capability of running an instance of HANS. There are currently three instances of HANS and each instance is synchronized to all other instances using a master-slave environment. Information can be entered on any node; slave nodes transmit data to the master node

  10. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo.

    PubMed

    Slungaard, Arne; Fernandez, Jose A; Griffin, John H; Key, Nigel S; Long, Janel R; Piegors, Donald J; Lentz, Steven R

    2003-07-01

    Platelet factor 4 (PF4), an abundant platelet alpha-granule protein, accelerates in vitro generation of activated protein C (APC) by soluble thrombin/thrombomodulin (TM) complexes up to 25-fold. To test the hypothesis that PF4 similarly stimulates endothelium-associated TM, we assessed the influence of human PF4 on thrombin-dependent APC generation by cultured endothelial monolayers. APC generated in the presence of 1 to 100 microg PF4 was up to 5-fold higher than baseline for human umbilical vein endothelial cells, 10-fold higher for microvascular endothelial cells, and unaltered for blood outgrowth endothelial cells. In an in vivo model, cynomolgus monkeys (n = 6, each serving as its own control) were infused with either PF4 (7.5 mg/kg) or vehicle buffer, then with human thrombin (1.0 microg/kg/min) for 10 minutes. Circulating APC levels (baseline 3 ng/mL) peaked at 10 minutes, when PF4-treated and vehicle-treated animals had APC levels of 67 +/- 5 ng/mL and 39 +/- 2 ng/mL, respectively (P <.001). The activated partial thromboplastin time (APTT; baseline, 28 seconds) increased maximally by 27 +/- 6 seconds in PF4-treated animals and by 9 +/- 1 seconds in control animals at 30 minutes (P <.001). PF4-dependent increases in circulating APC and APTT persisted more than 2-fold greater than that of controls from 10 through 120 minutes (P < or =.04). All APTT prolongations were essentially reversed by monoclonal antibody C3, which blocks APC activity. Thus, physiologically relevant concentrations of PF4 stimulate thrombin-dependent APC generation both in vitro by cultured endothelial cells and in vivo in a primate thrombin infusion model. These findings suggest that PF4 may play a previously unsuspected physiologic role in enhancing APC generation.

  11. 40 CFR 262.60 - Imports of hazardous waste.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Imports of hazardous waste. 262.60 Section 262.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60...

  12. Effects of Globally Waste Disturbing Activities on Gas Generation, Retention, and Release in Hanford Waste Tanks

    SciTech Connect

    Stewart, Charles W.; Fountain, Matthew S.; Huckaby, James L.; Mahoney, Lenna A.; Meyer, Perry A.; Wells, Beric E.

    2005-08-02

    Various operations are authorized in Hanford single- and double-shell tanks that disturb all or a large fraction of the waste. These globally waste-disturbing activities have the potential to release a large fraction of the retained flammable gas and to affect future gas generation, retention, and release behavior. This report presents analyses of the expected flammable gas release mechanisms and the potential release rates and volumes resulting from these activities. The background of the flammable gas safety issue at Hanford is summarized, as is the current understanding of gas generation, retention, and release phenomena. Considerations for gas monitoring and assessment of the potential for changes in tank classification and steady-state flammability are given.

  13. Integrating Community Volcanic Hazard Mapping, Geographic Information Systems, and Modeling to Reduce Volcanic Hazard Vulnerability

    NASA Astrophysics Data System (ADS)

    Bajo Sanchez, Jorge V.

    This dissertation is composed of an introductory chapter and three papers about vulnerability and volcanic hazard maps with emphasis on lahars. The introductory chapter reviews definitions of the term vulnerability by the social and natural hazard community and it provides a new definition of hazard vulnerability that includes social and natural hazard factors. The first paper explains how the Community Volcanic Hazard Map (CVHM) is used for vulnerability analysis and explains in detail a new methodology to obtain valuable information about ethnophysiographic differences, hazards, and landscape knowledge of communities in the area of interest: the Canton Buenos Aires situated on the northern flank of the Santa Ana (Ilamatepec) Volcano, El Salvador. The second paper is about creating a lahar hazard map in data poor environments by generating a landslide inventory and obtaining potential volumes of dry material that can potentially be carried by lahars. The third paper introduces an innovative lahar hazard map integrating information generated by the previous two papers. It shows the differences in hazard maps created by the communities and experts both visually as well as quantitatively. This new, integrated hazard map was presented to the community with positive feedback and acceptance. The dissertation concludes with a summary chapter on the results and recommendations.

  14. Seismic hazard assessment in Central Asia using smoothed seismicity approaches

    NASA Astrophysics Data System (ADS)

    Ullah, Shahid; Bindi, Dino; Zuccolo, Elisa; Mikhailova, Natalia; Danciu, Laurentiu; Parolai, Stefano

    2014-05-01

    Central Asia has a long history of large to moderate frequent seismicity and is therefore considered one of the most seismically active regions with a high hazard level in the world. In the hazard map produced at global scale by GSHAP project in 1999( Giardini, 1999), Central Asia is characterized by peak ground accelerations with return period of 475 years as high as 4.8 m/s2. Therefore Central Asia was selected as a target area for EMCA project (Earthquake Model Central Asia), a regional project of GEM (Global Earthquake Model) for this area. In the framework of EMCA, a new generation of seismic hazard maps are foreseen in terms of macro-seismic intensity, in turn to be used to obtain seismic risk maps for the region. Therefore Intensity Prediction Equation (IPE) had been developed for the region based on the distribution of intensity data for different earthquakes occurred in Central Asia since the end of 19th century (Bindi et al. 2011). The same observed intensity distribution had been used to assess the seismic hazard following the site approach (Bindi et al. 2012). In this study, we present the probabilistic seismic hazard assessment of Central Asia in terms of MSK-64 based on two kernel estimation methods. We consider the smoothed seismicity approaches of Frankel (1995), modified for considering the adaptive kernel proposed by Stock and Smith (2002), and of Woo (1996), modified for considering a grid of sites and estimating a separate bandwidth for each site. The activity rate maps are shown from Frankel approach showing the effects of fixed and adaptive kernel. The hazard is estimated for rock site condition based on 10% probability of exceedance in 50 years. Maximum intensity of about 9 is observed in the Hindukush region.

  15. Volcanism and associated hazards: the Andean perspective

    NASA Astrophysics Data System (ADS)

    Tilling, R. I.

    2009-12-01

    Andean volcanism occurs within the Andean Volcanic Arc (AVA), which is the product of subduction of the Nazca Plate and Antarctica Plates beneath the South America Plate. The AVA is Earth's longest but discontinuous continental-margin volcanic arc, which consists of four distinct segments: Northern Volcanic Zone, Central Volcanic Zone, Southern Volcanic Zone, and Austral Volcanic Zone. These segments are separated by volcanically inactive gaps that are inferred to indicate regions where the dips of the subducting plates are too shallow to favor the magma generation needed to sustain volcanism. The Andes host more volcanoes that have been active during the Holocene (past 10 000 years) than any other volcanic region in the world, as well as giant caldera systems that have produced 6 of the 47 largest explosive eruptions (so-called "super eruptions") recognized worldwide that have occurred from the Ordovician to the Pleistocene. The Andean region's most powerful historical explosive eruption occurred in 1600 at Huaynaputina Volcano (Peru). The impacts of this event, whose eruptive volume exceeded 11 km3, were widespread, with distal ashfall reported at distances >1000 km away. Despite the huge size of the Huaynaputina eruption, human fatalities from hazardous processes (pyroclastic flows, ashfalls, volcanogenic earthquakes, and lahars) were comparatively small owing to the low population density at the time. In contrast, lahars generated by a much smaller eruption (<0.05 km3) in 1985 of Nevado del Ruiz (Colombia) killed about 25 000 people - the worst volcanic disaster in the Andean region as well as the second worst in the world in the 20th century. The Ruiz tragedy has been attributed largely to ineffective communications of hazards information and indecisiveness by government officials, rather than any major deficiencies in scientific data. Ruiz's disastrous outcome, however, together with responses to subsequent hazardous eruptions in Chile, Colombia, Ecuador, and

  16. Volcanism and associated hazards: The Andean perspective

    USGS Publications Warehouse

    Tilling, R.I.

    2009-01-01

    Andean volcanism occurs within the Andean Volcanic Arc (AVA), which is the product of subduction of the Nazca Plate and Antarctica Plates beneath the South America Plate. The AVA is Earth's longest but discontinuous continental-margin volcanic arc, which consists of four distinct segments: Northern Volcanic Zone, Central Volcanic Zone, Southern Volcanic Zone, and Austral Volcanic Zone. These segments are separated by volcanically inactive gaps that are inferred to indicate regions where the dips of the subducting plates are too shallow to favor the magma generation needed to sustain volcanism. The Andes host more volcanoes that have been active during the Holocene (past 10 000 years) than any other volcanic region in the world, as well as giant caldera systems that have produced 6 of the 47 largest explosive eruptions (so-called "super eruptions") recognized worldwide that have occurred from the Ordovician to the Pleistocene.

    The Andean region's most powerful historical explosive eruption occurred in 1600 at Huaynaputina Volcano (Peru). The impacts of this event, whose eruptive volume exceeded 11 km3, were widespread, with distal ashfall reported at distances >1000 km away. Despite the huge size of the Huaynaputina eruption, human fatalities from hazardous processes (pyroclastic flows, ashfalls, volcanogenic earthquakes, and lahars) were comparatively small owing to the low population density at the time. In contrast, lahars generated by a much smaller eruption (<0.05 km 3) in 1985 of Nevado del Ruiz (Colombia) killed about 25 000 people - the worst volcanic disaster in the Andean region as well as the second worst in the world in the 20th century. The Ruiz tragedy has been attributed largely to ineffective communications of hazards information and indecisiveness by government officials, rather than any major deficiencies in scientific data. Ruiz's disastrous outcome, however, together with responses to subsequent hazardous eruptions in Chile, Colombia

  17. Generation of unipolar optical pulses in a Raman-active medium

    NASA Astrophysics Data System (ADS)

    Arkhipov, R. M.; Arkhipov, M. V.; Belov, P. A.; Tolmachev, Yu A.; Babushkin, I.

    2016-04-01

    Response of a Raman-active media (RAM) to the excitation by a series of ultrashort (few-cycle) optical pulses propagating at a superluminal velocity is studied theoretically. It is shown that under certain conditions rectangular unipolar pulses (video-pulses) can be generated as the RAM response. The duration, shape and amplitude of these video-pulses can be widely tuned by modifying the pump pulse parameters.

  18. Isolation and Analysis of Novel Electrochemically Active Bacteria for Enhanced Power Generation in Microbial Fuel Cells

    DTIC Science & Technology

    2009-03-07

    ISOLATION AND ANALYSIS OF NOVEL ELECTROCHEMICALLY ACTIVE BACTERIA FOR ENHANCED POWER GENERATION IN MICROBIAL FUEL CELLS B.E. Logan, J.M. Regan...new exoelectrogenic bacteria during this project. We isolated Rhodopseudomonas palustris DX-1, and demonstrated for the first time that a pure culture... isolated Ochrobactrum anthropi YZ-1, which had the remarkable characteristic that it was unable to respire using hydrous Fe(lll) oxide but produced

  19. Time-Elastic Generative Model for Acceleration Time Series in Human Activity Recognition

    PubMed Central

    Munoz-Organero, Mario; Ruiz-Blazquez, Ramona

    2017-01-01

    Body-worn sensors in general and accelerometers in particular have been widely used in order to detect human movements and activities. The execution of each type of movement by each particular individual generates sequences of time series of sensed data from which specific movement related patterns can be assessed. Several machine learning algorithms have been used over windowed segments of sensed data in order to detect such patterns in activity recognition based on intermediate features (either hand-crafted or automatically learned from data). The underlying assumption is that the computed features will capture statistical differences that can properly classify different movements and activities after a training phase based on sensed data. In order to achieve high accuracy and recall rates (and guarantee the generalization of the system to new users), the training data have to contain enough information to characterize all possible ways of executing the activity or movement to be detected. This could imply large amounts of data and a complex and time-consuming training phase, which has been shown to be even more relevant when automatically learning the optimal features to be used. In this paper, we present a novel generative model that is able to generate sequences of time series for characterizing a particular movement based on the time elasticity properties of the sensed data. The model is used to train a stack of auto-encoders in order to learn the particular features able to detect human movements. The results of movement detection using a newly generated database with information on five users performing six different movements are presented. The generalization of results using an existing database is also presented in the paper. The results show that the proposed mechanism is able to obtain acceptable recognition rates (F = 0.77) even in the case of using different people executing a different sequence of movements and using different hardware. PMID

  20. Dissipative soliton generation in an active ring resonator based on magnonic quasicrystal with Fibonacci type structure

    NASA Astrophysics Data System (ADS)

    Grishin, S. V.; Beginin, E. N.; Sharaevskii, Yu. P.; Nikitov, S. A.

    2013-07-01

    This study reports on the experimental investigations of a magnetostatic surface wave (MSSW) propagation in a magnonic quasicrystal (MQC) with Fibonacci type structure. It is shown that such structure has a greater number of band gaps and narrower pass bands located between them than a periodic structure. These features of the MQC and three-wave decay of the MSSW are used in a MQC active ring resonator for the eigenmode selection and dissipative soliton self-generation.

  1. Annual report of waste generation and pollution prevention progress 1995

    SciTech Connect

    1997-02-01

    This fourth Annual Report presents and analyzes 1995 DOE complex-wide waste generation and pollution prevention activities at 40 reporting sites in 25 States, and trends DOE waste generation from 1991 through 1995. DOE has established a 50% reduction goal (relative to the 1993 baseline) for routine operations radioactive and hazardous waste generation, due by December 31, 1999. Routine operations waste generation decreased 37% from 1994 to 1995, and 43% overall from 1993--1995.

  2. Generation of structurally novel short carotenoids and study of their biological activity.

    PubMed

    Kim, Se H; Kim, Moon S; Lee, Bun Y; Lee, Pyung C

    2016-02-23

    Recent research interest in phytochemicals has consistently driven the efforts in the metabolic engineering field toward microbial production of various carotenoids. In spite of systematic studies, the possibility of using C30 carotenoids as biologically functional compounds has not been explored thus far. Here, we generated 13 novel structures of C30 carotenoids and one C35 carotenoid, including acyclic, monocyclic, and bicyclic structures, through directed evolution and combinatorial biosynthesis, in Escherichia coli. Measurement of radical scavenging activity of various C30 carotenoid structures revealed that acyclic C30 carotenoids showed higher radical scavenging activity than did DL-α-tocopherol. We could assume high potential biological activity of the novel structures of C30 carotenoids as well, based on the neuronal differentiation activity observed for the monocyclic C30 carotenoid 4,4'-diapotorulene on rat bone marrow mesenchymal stem cells. Our results demonstrate that a series of structurally novel carotenoids possessing biologically beneficial properties can be synthesized in E. coli.

  3. Planning activity for internally generated reward goals in monkey amygdala neurons.

    PubMed

    Hernádi, István; Grabenhorst, Fabian; Schultz, Wolfram

    2015-03-01

    The best rewards are often distant and can only be achieved by planning and decision-making over several steps. We designed a multi-step choice task in which monkeys followed internal plans to save rewards toward self-defined goals. During this self-controlled behavior, amygdala neurons showed future-oriented activity that reflected the animal's plan to obtain specific rewards several trials ahead. This prospective activity encoded crucial components of the animal's plan, including value and length of the planned choice sequence. It began on initial trials when a plan would be formed, reappeared step by step until reward receipt, and readily updated with a new sequence. It predicted performance, including errors, and typically disappeared during instructed behavior. Such prospective activity could underlie the formation and pursuit of internal plans characteristic of goal-directed behavior. The existence of neuronal planning activity in the amygdala suggests that this structure is important in guiding behavior toward internally generated, distant goals.

  4. Coarse-grained simulations of an active filament propelled by a self-generated solute gradient

    NASA Astrophysics Data System (ADS)

    Sarkar, Debarati; Thakur, Snigdha

    2016-03-01

    A self-propelling semiflexible filament exhibits a variety of dynamical states depending on the flexibility and activity of the filament. Here we investigate the dynamics of such an active filament using a bead-spring model with the explicit hydrodynamic interactions. The activity in the filament is incorporated by inserting chemically active dimers at regular intervals along the chain. The chemical reactions at the catalytic bead of the dimer produces a self-generated concentration gradient and gives sufficient fuel to exhibit self-propulsion for the filament. Depending upon the rigidity and the configuration, the polymeric filament exhibits three distinct types of spontaneous motion, namely, rotational, snaking, and translational motion. The self-propulsion velocity of the filament for various rigidity and sizes has been calculated, and the factors affecting the propulsion are identified.

  5. Active fiber polymer cladding temperature measurement under conditions of laser generation and amplification

    NASA Astrophysics Data System (ADS)

    Sypin, V. E.; Prusakov, K. Y.; Ryabushkin, O. A.

    2016-04-01

    Polymer cladding temperature of active fiber in lasing regime is important parameter as it allows determination of fiber core temperature that in turn effects laser generation and amplification efficiency. Besides polymer cladding has much lower temperature damage threshold comparing to fused silica. For example, 200 degrees Kelvin overheating of the polymer cladding can result in fiber degradation. In present paper we introduce novel and simple method for precise temperature measurement of active fibers cladding under conditions of laser generation and amplification. Dependence of longitudinal temperature distribution along active fibers on optical pump power can be determined. This method employs measurement of temperature dependent electrical resistance of the metal wire being in thermal contact with fiber polymer cladding. The wire is reeled on the active fiber segment. Under lasing or amplification conditions the polymer cladding of the active fiber is heated together with coiled metal wire resulting in its electrical resistance change. By measuring resistance variation one can determine the temperature of the given fiber section.

  6. NO signalling decodes frequency of neuronal activity and generates synapse-specific plasticity in mouse cerebellum

    PubMed Central

    Namiki, Shigeyuki; Kakizawa, Sho; Hirose, Kenzo; Iino, Masamitsu

    2005-01-01

    Nitric oxide (NO) is an intercellular messenger regulating neuronal functions. To visualize NO signalling in the brain, we generated a novel fluorescent NO indicator, which consists of the heme-binding region (HBR) of soluble guanylyl cyclase and the green fluorescent protein. The indicator (HBR–GFP) was expressed in the Purkinje cells of the mouse cerebellum and we imaged NO signals in acute cerebellar slices upon parallel fibre (PF) activation with a train of burst stimulations (BS, each BS consisting of five pulses at 50 Hz). Our results showed that the intensity of synaptic NO signal decays steeply with the distance from the synaptic input near PF–Purkinje cell synapses and generates synapse-specific long-term potentiation (LTP). Furthermore, the NO release level has a bell-shaped dependence on the frequency of PF activity. At an optimal frequency (1 Hz), but not at a low frequency (0.25 Hz) of a train of 60 BS, NO release as well as LTP was induced. However, both NO release and LTP were significantly reduced at higher frequencies (2–4 Hz) of BS train due to cannabinoid receptor-mediated retrograde inhibition of NO generation at the PF terminals. These results suggest that synaptic NO signalling decodes the frequency of neuronal activity to mediate synaptic plasticity at the PF–Purkinje cell synapse. PMID:15919714

  7. [Central Pattern Generators: Mechanisms of the Activity and Their Role in the Control of "Automatic" Movements].

    PubMed

    Arshavsky, I; Deliagina, T G; Orlovsky, G N

    2015-01-01

    Central pattern generators (CPGs) are a set of interconnected neurons capable of generating a basic pattern of motor output underlying "automatic" movements (breathing, locomotion, chewing, swallowing, and so on) in the absence of afferent signals from the executive motor apparatus. They can be divided into the constitutive CPGs active throughout the entire lifetime (respiratory CPGs) and conditional CPGs controlling episodic movements (locomotion, chewing, swallowing, and others). Since a motor output of CPGs is determined by their internal organization, the activities of the conditional CPGs are initiated by simple commands coming from higher centers. We describe the structural and functional organization of the locomotor CPGs in the marine mollusk Clione limacina, lamprey, frog embryo, and laboratory mammals (cat, mouse, and rat), CPGs controlling the respiratory and swallowing movements in mammals, and CPGs controlling discharges of the electric organ in the gymnotiform fish. It is shown that in all these cases, the generation of rhythmic motor output is based both on the endogenous (pacemaker) activity of specific groups of interneurons and on interneural interactions. These two interrelated mechanisms complement each other, ensuring the high reliability of CPG functionality. We discuss how the experience obtained in studying CPGs can be used to understand mechanisms of more complex functions of the brain, including its cognitive functions.

  8. Health Care Wide Hazards

    MedlinePlus

    ... Electrical Ergonomics Fire Hazards Glutaraldehyde Hazardous Chemicals Infection Seasonal Flu MDRO - Multidrug-Resistant Organisms MRSA - Methicillin-resistant Staphylococcus aureus Latex Allergy Legionnaires' Disease Needlesticks Noise Mercury Inappropriate PPE Slips/ ...

  9. Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

    PubMed Central

    Altman, Raul; Scazziota, Alejandra Silvia; Herrera, Maria de Lourdes; Gonzalez, Claudio

    2006-01-01

    Background Platelet activation is crucial in normal hemostasis. Using a clotting system free of external tissue factor, we investigated whether activated Factor VII in combination with platelet agonists increased thrombin generation (TG) in vitro. Methods and results TG was quantified by time parameters: lag time (LT) and time to peak (TTP), and by amount of TG: peak of TG (PTG) and area under thrombin formation curve after 35 minutes (AUC→35min) in plasma from 29 healthy volunteers using the calibrated automated thrombography (CAT) technique. TG parameters were measured at basal conditions and after platelet stimulation by sodium arachidonate (AA), ADP, and collagen (Col). In addition, the effects of recombinant activated FVII (rFVIIa) alone or combined with the other platelet agonists on TG parameters were investigated. We found that LT and TTP were significantly decreased (p < 0.05) and PTG and AUC→35min were significantly increased (p < 0.05) in platelet rich plasma activated with AA, ADP, Col, and rFVIIa compared to non-activated platelet rich plasma from normal subjects (p = 0.01). Furthermore platelet rich plasma activated by the combined effects of rFVIIa plus AA, ADP or Col had significantly reduced LT and TTP and increased AUC→35min (but not PTG) when compared to platelet rich plasma activated with agonists in the absence of rFVIIa. Conclusion Platelets activated by AA, ADP, Col or rFVIIa triggered TG. This effect was increased by combining rFVIIa with other agonists. Our intrinsic coagulation system produced a burst in TG independent of external tissue factor activity an apparent hemostatic effect with little thrombotic capacity. Thus we suggest a modification in the cell-based model of hemostasis. PMID:16630353

  10. Hazard interactions and interaction networks (cascades) within multi-hazard methodologies

    NASA Astrophysics Data System (ADS)

    Gill, Joel C.; Malamud, Bruce D.

    2016-08-01

    This paper combines research and commentary to reinforce the importance of integrating hazard interactions and interaction networks (cascades) into multi-hazard methodologies. We present a synthesis of the differences between multi-layer single-hazard approaches and multi-hazard approaches that integrate such interactions. This synthesis suggests that ignoring interactions between important environmental and anthropogenic processes could distort management priorities, increase vulnerability to other spatially relevant hazards or underestimate disaster risk. In this paper we proceed to present an enhanced multi-hazard framework through the following steps: (i) description and definition of three groups (natural hazards, anthropogenic processes and technological hazards/disasters) as relevant components of a multi-hazard environment, (ii) outlining of three types of interaction relationship (triggering, increased probability, and catalysis/impedance), and (iii) assessment of the importance of networks of interactions (cascades) through case study examples (based on the literature, field observations and semi-structured interviews). We further propose two visualisation frameworks to represent these networks of interactions: hazard interaction matrices and hazard/process flow diagrams. Our approach reinforces the importance of integrating interactions between different aspects of the Earth system, together with human activity, into enhanced multi-hazard methodologies. Multi-hazard approaches support the holistic assessment of hazard potential and consequently disaster risk. We conclude by describing three ways by which understanding networks of interactions contributes to the theoretical and practical understanding of hazards, disaster risk reduction and Earth system management. Understanding interactions and interaction networks helps us to better (i) model the observed reality of disaster events, (ii) constrain potential changes in physical and social vulnerability

  11. Physical methods for generating and decoding neural activity in Hirudo verbana

    NASA Astrophysics Data System (ADS)

    Migliori, Benjamin John

    The interface between living nervous systems and hardware is an excellent proving ground for precision experimental methods and information classification systems. Nervous systems are complex (104 -- 10 15(!) connections), fragile, and highly active in intricate, constantly evolving patterns. However, despite the conveniently electrical nature of neural transmission, the interface between nervous systems and hardware poses significant experimental difficulties. As the desire for direct interfaces with neural signals continues to expand, the need for methods of generating and measuring neural activity with high spatiotemporal precision has become increasingly critical. In this thesis, I describe advances I have made in the ability to modify, generate, measure, and understand neural signals both in- and ex-vivo. I focus on methods developed for transmitting and extracting signals in the intact nervous system of Hirudo verbana (the medicinal leech), an animal with a minimally complex nervous system (10000 neurons distributed in packets along a nerve cord) that exhibits a diverse array of behaviors. To introduce artificial activity patterns, I developed a photothermal activation system in which a highly focused laser is used to irradiate carbon microparticles in contact with target neurons. The resulting local temperature increase generates an electrical current that forces the target neuron to fire neural signals, thereby providing a unique neural input mechanism. These neural signals can potentially be used to alter behavioral choice or generate specific behavioral output, and can be used endogenously in many animal models. I also describe new tools developed to expand the application of this method. In complement to this input system, I describe a new method of analyzing neural output signals involved in long-range coordination of behaviors. Leech behavioral signals are propagated between neural packets as electrical pulses in the nerve connective, a bundle of

  12. Helium generated cold plasma finely regulates activation of human fibroblast-like primary cells.

    PubMed

    Brun, Paola; Pathak, Surajit; Castagliuolo, Ignazio; Palù, Giorgio; Brun, Paola; Zuin, Matteo; Cavazzana, Roberto; Martines, Emilio

    2014-01-01

    Non-thermal atmospheric pressure plasmas are being developed for a wide range of health care applications, including wound healing. However in order to exploit the potential of plasma for clinical applications, the understanding of the mechanisms involved in plasma-induced activation of fibroblasts, the cells active in the healing process, is mandatory. In this study, the role of helium generated plasma in the tissue repairing process was investigated in cultured human fibroblast-like primary cells, and specifically in hepatic stellate cells and intestinal subepithelial myofibroblasts. Five minutes after treatment, plasma induced formation of reactive oxygen species (ROS) in cultured cells, as assessed by flow cytometric analysis of fluorescence-activated 2',7'-dichlorofluorescein diacetate probe. Plasma-induced intracellular ROS were characterized by lower concentrations and shorter half-lives with respect to hydrogen peroxide-induced ROS. Moreover ROS generated by plasma treatment increased the expression of peroxisome proliferator activated receptor (PPAR)-γ, nuclear receptor that modulates the inflammatory responses. Plasma exposure promoted wound healing in an in vitro model and induced fibroblast migration and proliferation, as demonstrated, respectively, by trans-well assay and partitioning between daughter cells of carboxyfluorescein diacetate succinimidyl ester fluorescent dye. Plasma-induced fibroblast migration and proliferation were found to be ROS-dependent as cellular incubation with antioxidant agents (e.g. N-acetyl L-cysteine) cancelled the biological effects. This study provides evidence that helium generated plasma promotes proliferation and migration in liver and intestinal fibroblast-like primary cells mainly by increasing intracellular ROS levels. Since plasma-evoked ROS are time-restricted and elicit the PPAR-γ anti-inflammatory molecular pathway, this strategy ensures precise regulation of human fibroblast activation and can be considered a

  13. Helium Generated Cold Plasma Finely Regulates Activation of Human Fibroblast-Like Primary Cells

    PubMed Central

    Brun, Paola; Pathak, Surajit; Castagliuolo, Ignazio; Palù, Giorgio; Brun, Paola; Zuin, Matteo; Cavazzana, Roberto; Martines, Emilio

    2014-01-01

    Non-thermal atmospheric pressure plasmas are being developed for a wide range of health care applications, including wound healing. However in order to exploit the potential of plasma for clinical applications, the understanding of the mechanisms involved in plasma-induced activation of fibroblasts, the cells active in the healing process, is mandatory. In this study, the role of helium generated plasma in the tissue repairing process was investigated in cultured human fibroblast-like primary cells, and specifically in hepatic stellate cells and intestinal subepithelial myofibroblasts. Five minutes after treatment, plasma induced formation of reactive oxygen species (ROS) in cultured cells, as assessed by flow cytometric analysis of fluorescence-activated 2′,7′-dichlorofluorescein diacetate probe. Plasma-induced intracellular ROS were characterized by lower concentrations and shorter half-lives with respect to hydrogen peroxide-induced ROS. Moreover ROS generated by plasma treatment increased the expression of peroxisome proliferator activated receptor (PPAR)-γ, nuclear receptor that modulates the inflammatory responses. Plasma exposure promoted wound healing in an in vitro model and induced fibroblast migration and proliferation, as demonstrated, respectively, by trans-well assay and partitioning between daughter cells of carboxyfluorescein diacetate succinimidyl ester fluorescent dye. Plasma-induced fibroblast migration and proliferation were found to be ROS-dependent as cellular incubation with antioxidant agents (e.g. N-acetyl L-cysteine) cancelled the biological effects. This study provides evidence that helium generated plasma promotes proliferation and migration in liver and intestinal fibroblast-like primary cells mainly by increasing intracellular ROS levels. Since plasma-evoked ROS are time-restricted and elicit the PPAR-γ anti-inflammatory molecular pathway, this strategy ensures precise regulation of human fibroblast activation and can be

  14. 76 FR 36879 - Minnesota: Final Authorization of State Hazardous Waste Management Program Revision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-23

    ... 142A; Specific Provisions for Batteries, Checklist 142B; Specific Provisions for Pesticides, Checklist..., Storage and Disposal Facilities and Hazardous Waste Generators; Organic Air Emissions Standards for Tanks... Facilities and Hazardous Waste Generators; Organic Air Emissions Standards for Tanks, Surface...

  15. Hazardous Waste Minimization Assessment: Fort Sam Houston, Texas

    DTIC Science & Technology

    1991-01-01

    Houston has a number of power production and heating/cooling plants ( HCP ) that use hazardous materials and generate potentially hazardous wastes. The DEH...Training and Support Center - Photo, Print Section; Buildings 2010, 2016 2. DPTMSEC - Training and Support Center - Graphics Section; Building 1450 3...Hazardous Waste Minimization HCL Hospitals, Clinics, and Laboratories HCP Heating/Cooling Plants HMTC Hazardous Materials Technical Center HSC Health

  16. Success in transmitting hazard science

    NASA Astrophysics Data System (ADS)

    Price, J. G.; Garside, T.

    2010-12-01

    Money motivates mitigation. An example of success in communicating scientific information about hazards, coupled with information about available money, is the follow-up action by local governments to actually mitigate. The Nevada Hazard Mitigation Planning Committee helps local governments prepare competitive proposals for federal funds to reduce risks from natural hazards. Composed of volunteers with expertise in emergency management, building standards, and earthquake, flood, and wildfire hazards, the committee advises the Nevada Division of Emergency Management on (1) the content of the State’s hazard mitigation plan and (2) projects that have been proposed by local governments and state agencies for funding from various post- and pre-disaster hazard mitigation programs of the Federal Emergency Management Agency. Local governments must have FEMA-approved hazard mitigation plans in place before they can receive this funding. The committee has been meeting quarterly with elected and appointed county officials, at their offices, to encourage them to update their mitigation plans and apply for this funding. We have settled on a format that includes the county’s giving the committee an overview of its infrastructure, hazards, and preparedness. The committee explains the process for applying for mitigation grants and presents the latest information that we have about earthquake hazards, including locations of nearby active faults, historical seismicity, geodetic strain, loss-estimation modeling, scenarios, and documents about what to do before, during, and after an earthquake. Much of the county-specific information is available on the web. The presentations have been well received, in part because the committee makes the effort to go to their communities, and in part because the committee is helping them attract federal funds for local mitigation of not only earthquake hazards but also floods (including canal breaches) and wildfires, the other major concerns in

  17. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells.

    PubMed

    Paruchuri, Sailaja; Jiang, Yongfeng; Feng, Chunli; Francis, Sanjeev A; Plutzky, Jorge; Boyce, Joshua A

    2008-06-13

    Cysteinyl leukotrienes (cys-LTs) are potent inflammatory lipid mediators, of which leukotriene (LT) E(4) is the most stable and abundant in vivo. Although only a weak agonist of established G protein-coupled receptors (GPCRs) for cys-LTs, LTE(4) potentiates airway hyper-responsiveness (AHR) by a cyclooxygenase (COX)-dependent mechanism and induces bronchial eosinophilia. We now report that LTE(4) activates human mast cells (MCs) by a pathway involving cooperation between an MK571-sensitive GPCR and peroxisome proliferator-activated receptor (PPAR)gamma, a nuclear receptor for dietary lipids. Although LTD(4) is more potent than LTE(4) for inducing calcium flux by the human MC sarcoma line LAD2, LTE(4) is more potent for inducing proliferation and chemokine generation, and is at least as potent for upregulating COX-2 expression and causing prostaglandin D(2) (PGD(2)) generation. LTE(4) caused phosphorylation of extracellular signal-regulated kinase (ERK), p90RSK, and cyclic AMP-regulated-binding protein (CREB). ERK activation in response to LTE(4), but not to LTD(4), was resistant to inhibitors of phosphoinositol 3-kinase. LTE(4)-mediated COX-2 induction, PGD(2) generation, and ERK phosphorylation were all sensitive to interference by the PPARgamma antagonist GW9662 and to targeted knockdown of PPARgamma. Although LTE(4)-mediated PGD(2) production was also sensitive to MK571, an antagonist for the type 1 receptor for cys-LTs (CysLT(1)R), it was resistant to knockdown of this receptor. This LTE(4)-selective receptor-mediated pathway may explain the unique physiologic responses of human airways to LTE(4) in vivo.

  18. Hazard function theory for nonstationary natural hazards

    NASA Astrophysics Data System (ADS)

    Read, Laura K.; Vogel, Richard M.

    2016-04-01

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e., that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk, and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied generalized Pareto model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. Our theoretical analysis linking hazard random variable X with corresponding failure time series T should have application to a wide class of natural hazards with opportunities for future extensions.

  19. Hazard function theory for nonstationary natural hazards

    NASA Astrophysics Data System (ADS)

    Read, L. K.; Vogel, R. M.

    2015-11-01

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e. that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied Generalized Pareto (GP) model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. Our theoretical analysis linking hazard event series X, with corresponding failure time series T, should have application to a wide class of natural hazards with rich opportunities for future extensions.

  20. Hazard function theory for nonstationary natural hazards

    DOE PAGES

    Read, Laura K.; Vogel, Richard M.

    2016-04-11

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e., that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field ofmore » hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk, and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied generalized Pareto model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. As a result, our theoretical analysis linking hazard random variable X with corresponding failure time series T should have application to a wide class of natural hazards with opportunities for future extensions.« less

  1. Hazard function theory for nonstationary natural hazards

    SciTech Connect

    Read, Laura K.; Vogel, Richard M.

    2016-04-11

    Impact from natural hazards is a shared global problem that causes tremendous loss of life and property, economic cost, and damage to the environment. Increasingly, many natural processes show evidence of nonstationary behavior including wind speeds, landslides, wildfires, precipitation, streamflow, sea levels, and earthquakes. Traditional probabilistic analysis of natural hazards based on peaks over threshold (POT) generally assumes stationarity in the magnitudes and arrivals of events, i.e., that the probability of exceedance of some critical event is constant through time. Given increasing evidence of trends in natural hazards, new methods are needed to characterize their probabilistic behavior. The well-developed field of hazard function analysis (HFA) is ideally suited to this problem because its primary goal is to describe changes in the exceedance probability of an event over time. HFA is widely used in medicine, manufacturing, actuarial statistics, reliability engineering, economics, and elsewhere. HFA provides a rich theory to relate the natural hazard event series (X) with its failure time series (T), enabling computation of corresponding average return periods, risk, and reliabilities associated with nonstationary event series. This work investigates the suitability of HFA to characterize nonstationary natural hazards whose POT magnitudes are assumed to follow the widely applied generalized Pareto model. We derive the hazard function for this case and demonstrate how metrics such as reliability and average return period are impacted by nonstationarity and discuss the implications for planning and design. As a result, our theoretical analysis linking hazard random variable X with corresponding failure time series T should have application to a wide class of natural hazards with opportunities for future extensions.

  2. Iso standardization of theoretical activity evaluation method for low and intermediate level activated waste generated at nuclear power plants

    SciTech Connect

    Makoto Kashiwagi; Garamszeghy, Mike; Lantes, Bertrand; Bonne, Sebastien; Pillette-Cousin, Lucien; Leganes, Jose Luis; Volmert, Ben; James, David W.

    2013-07-01

    Disposal of low-and intermediate-level activated waste generated at nuclear power plants is being planned or carried out in many countries. The radioactivity concentrations and/or total quantities of long-lived, difficult-to-measure nuclides (DTM nuclides), such as C-14, Ni-63, Nb-94, α emitting nuclides etc., are often restricted by the safety case for a final repository as determined by each country's safety regulations, and these concentrations or amounts are required to be known and declared. With respect to waste contaminated by contact with process water, the Scaling Factor method (SF method), which is empirically based on sampling and analysis data, has been applied as an important method for determining concentrations of DTM nuclides. This method was standardized by the International Organization for Standardization (ISO) and published in 2007 as ISO21238 'Scaling factor method to determine the radioactivity of low and intermediate-level radioactive waste packages generated at nuclear power plants' [1]. However, for activated metal waste with comparatively high concentrations of radioactivity, such as may be found in reactor control rods and internal structures, direct sampling and radiochemical analysis methods to evaluate the DTM nuclides are limited by access to the material and potentially high personnel radiation exposure. In this case, theoretical calculation methods in combination with empirical methods based on remote radiation surveys need to be used to best advantage for determining the disposal inventory of DTM nuclides while minimizing exposure to radiation workers. Pursuant to this objective a standard for the theoretical evaluation of the radioactivity concentration of DTM nuclides in activated waste, is in process through ISO TC85/SC5 (ISO Technical Committee 85: Nuclear energy, nuclear technologies, and radiological protection; Subcommittee 5: Nuclear fuel cycle). The project team for this ISO standard was formed in 2011 and is composed of

  3. Motor cortex activation in Parkinson's disease: dissociation of electrocortical and peripheral measures of response generation.

    PubMed

    Praamstra, P; Plat, E M; Meyer, A S; Horstink, M W

    1999-09-01

    This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise-compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal-related and movement-related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement-related neural activity.

  4. Fish Swimming: Patternsin the Mechanical Energy Generation, Transmission and Dissipation from Muscle Activation to Body Movement

    NASA Astrophysics Data System (ADS)

    Zhang, W.; Yu, Y. L.; Tong, B. G.

    2011-09-01

    The power consumption of the undulatory fish swimming is produced by active muscles. The mechanical energy generated by stimulated muscles is dissipated partly by the passive tissues of fish while it is being transmitted to the fluid medium. Furthermore, the effective energy, propelling fish movement, is a part of that delivered by the fish body. The process depends on the interactions of the active muscles, the passive tissues, and the water surrounding the fish body. In the previous works, the body-fluid interactions have been investigated widely, but it is rarely considered how the mechanical energy generates, transmits and dissipates in fish swimming. This paper addresses the regular patterns of energy transfer process from muscle activation to body movement for a cruising lamprey (LAMPREY), a kind of anguilliform swimmer. It is necessary to propose a global modelling of the kinematic chain, which is composed of active muscle force-moment model, fish-body dynamic model and hydrodynamic model in order. The present results show that there are traveling energy waves along the fish body from anterior to posterior, accompanied with energy storing and dissipating due to the viscoelastic property of internal tissues. This study is a preliminary research on the framework of kinematic chain coordination performance in fish swimming.

  5. Chemical Safety Alert: Fire Hazard from Carbon Adsorption Deodorizing Systems

    EPA Pesticide Factsheets

    Activated carbon systems used to adsorb vapors for odor control may pose a fire hazard when used for certain types of substances, such as crude sulfate turpentine. Facilities should take precautions and proper procedures to avoid or mitigate these hazards.

  6. 32 CFR 935.161 - Fire hazards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Fire hazards. 935.161 Section 935.161 National... WAKE ISLAND CODE Public Safety § 935.161 Fire hazards. (a) Each person engaged in a business or other activity on Wake Island shall, at his expense, provide and maintain (in an accessible location)...

  7. 32 CFR 935.161 - Fire hazards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Fire hazards. 935.161 Section 935.161 National... WAKE ISLAND CODE Public Safety § 935.161 Fire hazards. (a) Each person engaged in a business or other activity on Wake Island shall, at his expense, provide and maintain (in an accessible location)...

  8. 32 CFR 935.161 - Fire hazards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Fire hazards. 935.161 Section 935.161 National... WAKE ISLAND CODE Public Safety § 935.161 Fire hazards. (a) Each person engaged in a business or other activity on Wake Island shall, at his expense, provide and maintain (in an accessible location)...

  9. 32 CFR 935.161 - Fire hazards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Fire hazards. 935.161 Section 935.161 National... WAKE ISLAND CODE Public Safety § 935.161 Fire hazards. (a) Each person engaged in a business or other activity on Wake Island shall, at his expense, provide and maintain (in an accessible location)...

  10. 32 CFR 935.161 - Fire hazards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Fire hazards. 935.161 Section 935.161 National... WAKE ISLAND CODE Public Safety § 935.161 Fire hazards. (a) Each person engaged in a business or other activity on Wake Island shall, at his expense, provide and maintain (in an accessible location)...

  11. Military hazardous wastes: an overview and analysis

    SciTech Connect

    Kawaoka, K.E.; Malloy, M.C.; Dever, G.L.; Weinberger, L.P.

    1981-12-01

    The report describes and analyzes the management activities and motivating factors of the military in dealing with its hazardous waste streams. Findings and conclusions in areas of concern are given to provide information that may be of value to the future management of military hazardous wastes.

  12. Laser Hazards Bibliography - November 1980.

    DTIC Science & Technology

    1980-11-01

    W., and Schmidt, I., Protection against photic damage in retinitis pigmentosa , Adv Exp Med Biol, 77: 233-247 (1977). 2. Agarwal, L. P., and Malik, S...Laser Exposure imits ...................... 180 C. Optical Radiation Hazards - General Reviews...... 181 D. Retinal Burns from Lasers...radiation, Soy J Quantum Electron, 8: 552 (1978). 3. Anonymous, Use of various types of quantium generators in retinal diseases, Oftalmol Zh, 33(5): 323-324

  13. Reticular activating system of a central pattern generator: premovement electrical potentials.

    PubMed

    Tapia, Jesus A; Trejo, Argelia; Linares, Pablo; Alva, J Manuel; Kristeva, Rumyana; Manjarrez, Elias

    2013-10-01

    For the first time, here we characterize a bulbar reticular activating system (RAS) of neurons in decerebrate, deafferented and decerebellated cats producing a premovement electrical potential that we named obex slow potential (OSP). The OSP occurs about 0.8 ± 0.4 sec prior to the onset of a fictive-scratching-episode. Here, we describe two classes of bulbar neurons, off-on, which are silent but exhibit a 80 ± 56 Hz firing discharge at the beginning of (and during) the OSP, and on-off interneurons, with a 27 ± 14 Hz firing activity that stops at the beginning of (and during) the OSP. We suggest that these OSP-associated neurons belong to a descending RAS, which contributes to the activation of the spinal central pattern generators.

  14. Tailored motivational message generation: A model and practical framework for real-time physical activity coaching.

    PubMed

    Op den Akker, Harm; Cabrita, Miriam; Op den Akker, Rieks; Jones, Valerie M; Hermens, Hermie J

    2015-06-01

    This paper presents a comprehensive and practical framework for automatic generation of real-time tailored messages in behavior change applications. Basic aspects of motivational messages are time, intention, content and presentation. Tailoring of messages to the individual user may involve all aspects of communication. A linear modular system is presented for generating such messages. It is explained how properties of user and context are taken into account in each of the modules of the system and how they affect the linguistic presentation of the generated messages. The model of motivational messages presented is based on an analysis of existing literature as well as the analysis of a corpus of motivational messages used in previous studies. The model extends existing 'ontology-based' approaches to message generation for real-time coaching systems found in the literature. Practical examples are given on how simple tailoring rules can be implemented throughout the various stages of the framework. Such examples can guide further research by clarifying what it means to use e.g. user targeting to tailor a message. As primary example we look at the issue of promoting daily physical activity. Future work is pointed out in applying the present model and framework, defining efficient ways of evaluating individual tailoring components, and improving effectiveness through the creation of accurate and complete user- and context models.

  15. Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability

    PubMed Central

    Montgomery, Jenna R.; Meredith, Andrea L.

    2012-01-01

    Large-conductance calcium-activated potassium channels (BK) are potent negative regulators of excitability in neurons and muscle, and increasing BK current is a novel therapeutic strategy for neuro- and cardioprotection, disorders of smooth muscle hyperactivity, and several psychiatric diseases. However, in some neurons, enhanced BK current is linked with seizures and paradoxical increases in excitability, potentially complicating the clinical use of agonists. The mechanisms that switch BK influence from inhibitory to excitatory are not well defined. Here we investigate this dichotomy using a gain-of-function subunit (BKR207Q) to enhance BK currents. Heterologous expression of BKR207Q generated currents that activated at physiologically relevant voltages in lower intracellular Ca2+, activated faster, and deactivated slower than wild-type currents. We then used BKR207Q expression to broadly augment endogenous BK currents in vivo, generating a transgenic mouse from a circadian clock-controlled Period1 gene fragment (Tg-BKR207Q). The specific impact on excitability was assessed in neurons of the suprachiasmatic nucleus (SCN) in the hypothalamus, a cell type where BK currents regulate spontaneous firing under distinct day and night conditions that are defined by different complements of ionic currents. In the SCN, Tg-BKR207Q expression converted the endogenous BK current to fast-activating, while maintaining similar current-voltage properties between day and night. Alteration of BK currents in Tg-BKR207Q SCN neurons increased firing at night but decreased firing during the day, demonstrating that BK currents generate bidirectional effects on neuronal firing under distinct conditions. PMID:23112153

  16. p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation

    PubMed Central

    Jin, Huan; Yin, Shutao; Song, Xinhua; Zhang, Enxiang; Fan, Lihong; Hu, Hongbo

    2016-01-01

    Patulin is a major mycotoxin found in fungal contaminated fruits and their derivative products. Previous studies showed that patulin was able to induce increase of reactive oxygen species (ROS) generation and oxidative stress was suggested to play a pivotal role in patulin-induced multiple toxic signaling. The objective of the present study was to investigate the functional role of p53 in patulin-induced oxidative stress. Our study demonstrated that higher levels of ROS generation and DNA damage were induced in wild-type p53 cell lines than that found in either knockdown or knockout p53 cell lines in response to patulin exposure, suggesting p53 activation contributed to patulin-induced ROS generation. Mechanistically, we revealed that the pro-oxidant role of p53 in response to patulin was attributed to its ability to suppress catalase activity through up-regulation of PIG3. Moreover, these in vitro findings were further validated in the p53 wild-type/knockout mouse model. To the best of our knowledge, this is the first report addressing the functional role of p53 in patulin-induced oxidative stress. The findings of the present study provided novel insights into understanding mechanisms behind oxidative stress in response to patulin exposure. PMID:27071452

  17. Volcanic hazard management in dispersed volcanism areas

    NASA Astrophysics Data System (ADS)

    Marrero, Jose Manuel; Garcia, Alicia; Ortiz, Ramon

    2014-05-01

    Traditional volcanic hazard methodologies were developed mainly to deal with the big stratovolcanoes. In such type of volcanoes, the hazard map is an important tool for decision-makers not only during a volcanic crisis but also for territorial planning. According to the past and recent eruptions of a volcano, all possible volcanic hazards are modelled and included in the hazard map. Combining the hazard map with the Event Tree the impact area can be zoned and defining the likely eruptive scenarios that will be used during a real volcanic crisis. But in areas of disperse volcanism is very complex to apply the same volcanic hazard methodologies. The event tree do not take into account unknown vents, because the spatial concepts included in it are only related with the distance reached by volcanic hazards. The volcanic hazard simulation is also difficult because the vent scatter modifies the results. The volcanic susceptibility try to solve this problem, calculating the most likely areas to have an eruption, but the differences between low and large values obtained are often very small. In these conditions the traditional hazard map effectiveness could be questioned, making necessary a change in the concept of hazard map. Instead to delimit the potential impact areas, the hazard map should show the expected behaviour of the volcanic activity and how the differences in the landscape and internal geo-structures could condition such behaviour. This approach has been carried out in La Palma (Canary Islands), combining the concept of long-term hazard map with the short-term volcanic scenario to show the expected volcanic activity behaviour. The objective is the decision-makers understand how a volcanic crisis could be and what kind of mitigation measurement and strategy could be used.

  18. Washington Tsunami Hazard Mitigation Program

    NASA Astrophysics Data System (ADS)

    Walsh, T. J.; Schelling, J.

    2012-12-01

    Washington State has participated in the National Tsunami Hazard Mitigation Program (NTHMP) since its inception in 1995. We have participated in the tsunami inundation hazard mapping, evacuation planning, education, and outreach efforts that generally characterize the NTHMP efforts. We have also investigated hazards of significant interest to the Pacific Northwest. The hazard from locally generated earthquakes on the Cascadia subduction zone, which threatens tsunami inundation in less than hour following a magnitude 9 earthquake, creates special problems for low-lying accretionary shoreforms in Washington, such as the spits of Long Beach and Ocean Shores, where high ground is not accessible within the limited time available for evacuation. To ameliorate this problem, we convened a panel of the Applied Technology Council to develop guidelines for construction of facilities for vertical evacuation from tsunamis, published as FEMA 646, now incorporated in the International Building Code as Appendix M. We followed this with a program called Project Safe Haven (http://www.facebook.com/ProjectSafeHaven) to site such facilities along the Washington coast in appropriate locations and appropriate designs to blend with the local communities, as chosen by the citizens. This has now been completed for the entire outer coast of Washington. In conjunction with this effort, we have evaluated the potential for earthquake-induced ground failures in and near tsunami hazard zones to help develop cost estimates for these structures and to establish appropriate tsunami evacuation routes and evacuation assembly areas that are likely to to be available after a major subduction zone earthquake. We intend to continue these geotechnical evaluations for all tsunami hazard zones in Washington.

  19. Volcano hazards in the Mount Hood region, Oregon

    USGS Publications Warehouse

    Scott, W.E.; Pierson, T.C.; Schilling, S.P.; Costa, J.E.; Gardner, C.A.; Vallance, J.W.; Major, J.J.

    1997-01-01

    Mount Hood is a potentially active volcano close to rapidly growing communities and recreation areas. The most likely widespread and hazardous consequence of a future eruption will be for lahars (rapidly moving mudflows) to sweep down the entire length of the Sandy (including the Zigzag) and White River valleys. Lahars can be generated by hot volcanic flows that melt snow and ice or by landslides from the steep upper flanks of the volcano. Structures close to river channels are at greatest risk of being destroyed. The degree of hazard decreases as height above a channel increases, but large lahars can affect areas more than 30 vertical meters (100 vertical feet) above river beds. The probability of eruption-generated lahars affecting the Sandy and White River valleys is 1-in-15 to l-in-30 during the next 30 years, whereas the probability of extensive areas in the Hood River Valley being affected by lahars is about ten times less. The accompanying volcano-hazard-zonation map outlines areas potentially at risk and shows that some areas may be too close for a reasonable chance of escape or survival during an eruption. Future eruptions of Mount Hood could seriously disrupt transportation (air, river, and highway), some municipal water supplies, and hydroelectric power generation and transmission in northwest Oregon and southwest Washington.

  20. Feijoa sellowiana Berg fruit juice: anti-inflammatory effect and activity on superoxide anion generation.

    PubMed

    Monforte, Maria T; Fimiani, Vincenzo; Lanuzza, Francesco; Naccari, Clara; Restuccia, Salvatore; Galati, Enza M

    2014-04-01

    Feijoa sellowiana Berg var. coolidge fruit juice was studied in vivo for the anti-inflammatory activity by carrageenin-induced paw edema test and in vitro for the effects on superoxide anion release from neutrophils in human whole blood. The fruit juice was analyzed by the high-performance liquid chromatography method, and quercetin, ellagic acid, catechin, rutin, eriodictyol, gallic acid, pyrocatechol, syringic acid, and eriocitrin were identified. The results showed a significant anti-inflammatory activity of F. sellowiana fruit juice, sustained also by an effective antioxidant activity observed in preliminary studies on 1,1-diphenyl-2-picrylhydrazyl (DPPH) test. In particular, the anti-inflammatory activity edema inhibition is significant since the first hour (44.11%) and persists until the fifth hour (44.12%) of the treatment. The effect on superoxide anion release was studied in human whole blood, in the presence of activators affecting neutrophils by different mechanisms. The juice showed an inhibiting response on neutrophils basal activity in all experimental conditions. In stimulated neutrophils, the higher inhibition of superoxide anion generation was observed at concentration of 10(-4) and 10(-2) mg/mL in whole blood stimulate with phorbol-myristate-13-acetate (PMA; 20% and 40%) and with N-formyl-methionyl-leucyl-phenylalanine (FMLP; 15% and 48%). The significant reduction of edema and the inhibition of O2(-) production, occurring mainly through interaction with protein-kinase C pathway, confirm the anti-inflammatory effect of F. sellowiana fruit juice.

  1. Analysis of crystal structure of Arabidopsis MPK6 and generation of its mutants with higher activity.

    PubMed

    Wang, Bo; Qin, Xinghua; Wu, Juan; Deng, Hongying; Li, Yuan; Yang, Hailian; Chen, Zhongzhou; Liu, Guoqin; Ren, Dongtao

    2016-05-10

    Mitogen-activated protein kinase (MAPK) cascades, which are the highly conserved signalling modules in eukaryotic organisms, have been shown to play important roles in regulating growth, development, and stress responses. The structures of various MAPKs from yeast and animal have been solved, and structure-based mutants were generated for their function analyses, however, the structures of plant MAPKs remain unsolved. Here, we report the crystal structure of Arabidopsis MPK6 at a 3.0 Å resolution. Although MPK6 is topologically similar to ERK2 and p38, the structures of the glycine-rich loop, MAPK insert, substrate binding sites, and L16 loop in MPK6 show notable differences from those of ERK2 and p38. Based on the structural comparison, we constructed MPK6 mutants and analyzed their kinase activity both in vitro and in planta. MPK6(F364L) and MPK6(F368L) mutants, in which Phe364 and Phe368 in the L16 loop were changed to Leu, respectively, acquired higher intrinsic kinase activity and retained the normal MAPKK activation property. The expression of MPK6 mutants with basal activity is sufficient to induce camalexin biosynthesis; however, to induce ethylene and leaf senescence, the expression of MPK6 mutants with higher activity is required. The results suggest that these mutants can be used to analyze the specific biological functions of MPK6.

  2. Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials

    PubMed Central

    Garden, Derek L. F.; Rinaldi, Arianna

    2016-01-01

    Key points We establish experimental preparations for optogenetic investigation of glutamatergic input to the inferior olive.Neurones in the principal olivary nucleus receive monosynaptic extra‐somatic glutamatergic input from the neocortex.Glutamatergic inputs to neurones in the inferior olive generate bidirectional postsynaptic potentials (PSPs), with a fast excitatory component followed by a slower inhibitory component.Small conductance calcium‐activated potassium (SK) channels are required for the slow inhibitory component of glutamatergic PSPs and oppose temporal summation of inputs at intervals ≤ 20 ms.Active integration of synaptic input within the inferior olive may play a central role in control of olivo‐cerebellar climbing fibre signals. Abstract The inferior olive plays a critical role in motor coordination and learning by integrating diverse afferent signals to generate climbing fibre inputs to the cerebellar cortex. While it is well established that climbing fibre signals are important for motor coordination, the mechanisms by which neurones in the inferior olive integrate synaptic inputs and the roles of particular ion channels are unclear. Here, we test the hypothesis that neurones in the inferior olive actively integrate glutamatergic synaptic inputs. We demonstrate that optogenetically activated long‐range synaptic inputs to the inferior olive, including projections from the motor cortex, generate rapid excitatory potentials followed by slower inhibitory potentials. Synaptic projections from the motor cortex preferentially target the principal olivary nucleus. We show that inhibitory and excitatory components of the bidirectional synaptic potentials are dependent upon AMPA (GluA) receptors, are GABAA independent, and originate from the same presynaptic axons. Consistent with models that predict active integration of synaptic inputs by inferior olive neurones, we find that the inhibitory component is reduced by blocking large conductance

  3. Active control of highly efficient third-harmonic generation in ultrathin nonlinear metasurfaces

    NASA Astrophysics Data System (ADS)

    Gong, Zibo; Li, Chong; Hu, Xiaoyong; Yang, Hong; Gong, Qihuang

    2016-10-01

    Active electric control of highly efficient third harmonic generation was realized in an ultrathin nonlinear metasurface by using a nanocomposite consisting of gold nanoparticles dispersed in polycrystalline strontium titanate as the electro-optic material. Owing to the nonlinearity enhancement associated with the slow light effect, quantum confinement effect, and field-reinforcement, a high conversion efficiency of 3 × 10-5 was obtained, which is two orders of magnitude larger than previously reported efficiencies at comparable pump intensities. A modulation of 12% in the intensity of the third harmonic generation and a 30-nm shift in the transparency window center were achieved by varying the applied voltage from -30 V to zero. Our results pave the way toward the realization of multi-functional integrated photonic devices and chips based on metasurfaces.

  4. Three-dimensional analysis of optical forces generated by an active tractor beam using radial polarization.

    PubMed

    Carretero, Luis; Acebal, Pablo; Blaya, Salvador

    2014-02-10

    We theoretically study the three-dimensional behavior of nanoparticles in an active optical conveyor. To do this, we solved the Langevin equation when the forces are generated by a focusing system at the near field. Analytical expressions for the optical forces generated by the optical conveyor were obtained by solving the Richards and Wolf vectorial diffraction integrals in an approximated form when a mask of two annular pupils is illuminated by a radially polarized Hermite-Gauss beam. Trajectories, in both the transverse plane and the longitudinal direction, are analyzed showing that the behavior of the optical conveyor can be optimized by conveniently choosing the configuration of the mask of the two annular pupils (inner and outer radius of the two rings) in order to trap and transport all particles at the focal plane.

  5. Development of Visualisations for Multi-Hazard Environments in Guatemala

    NASA Astrophysics Data System (ADS)

    Gill, Joel; Malamud, Bruce D.

    2015-04-01

    Here we present an adaptation of global interacting hazard matrices for the purpose of improving disaster risk reduction in multi-hazard environments of Guatemala. Guatemala is associated with multiple natural hazards, including volcanic eruptions, earthquakes, mass movements and floods. These processes are often not independent and it is therefore important to consider and understand the ways by which they interact to generate cascades or networks of natural hazard events. We first present a review of such hazard interactions and hazard chains in Guatemala, focusing on the volcanic environments around Pacaya, Fuego and Santiaguito. Interactions discussed are those where a primary hazard triggers or increases the probability of secondary hazards. Consideration is also given to interactions where two hazards combine to trigger a third hazard, or two concurring hazards result in impacts greater than the sum of components. Second, we utilise and adapt global interacting hazard matrices designed to understand and communicate information about interactions. We explore the use of this hazard visualisation framework within the more regional Guatemalan context. Twenty-one semi-structured interviews, and a workshop with 16 participants, were held with hazard and civil protection professionals in Guatemala to solicit feedback on: (i) how visualisations with a global focus can be modified for use in Guatemala, (ii) possible end users for such visualisations, and (iii) participants' understanding of hazard interactions and their opinion of community understanding of these themes. Core ideas that emerged from these interviews were (i) the importance of such tools in rapid response, preparedness and community education, (ii) the appropriate scales for visualisation development, in order to have maximum impact, and (iii) the need to integrate anthropic factors to fully understand hazard cascades. It is hoped that the development of improved tools to understand natural hazard

  6. Runoff inundation hazard cartography

    NASA Astrophysics Data System (ADS)

    Pineux, N.; Degré, A.

    2012-04-01

    Between 1998 and 2004, Europe suffered from more than hundred major inundations, responsible for some 700 deaths, for the moving of about half a million of people and the economic losses of at least 25 billions Euros covered by the insurance policies. Within this context, EU launched the 2007/60/CE directive. The inundations are natural phenomenon. They cannot be avoided. Nevertheless this directive permits to better evaluate the risks and to coordinate the management measures taken at member states level. In most countries, inundation maps only include rivers' overflowing. In Wallonia, overland flows and mudflows also cause huge damages, and must be included in the flood hazard map. Indeed, the cleaning operations for a village can lead to an estimated cost of 11 000 €. Average construction cost of retention dams to control off-site damage caused by floods and muddy flows was valued at 380 000€, and yearly dredging costs associated with these retention ponds at 15 000€. For a small city for which a study was done in a more specific way (Gembloux), the mean annual cost for the damages that can generate the runoff is about 20 000€. This cost consists of the physical damages caused to the real estate and movable properties of the residents as well as the emergency operations of the firemen and the city. On top of damages to public infrastructure (clogging of trenches, silting up of retention ponds) and to private property by muddy flows, runoff generates a significant loss of arable land. Yet, the soil resource is not an unlimited commodity. Moreover, sediments' transfer to watercourses alters their physical and chemical quality. And that is not to mention the increased psychological stress for people. But to map overland flood and mud flow hazard is a real challenge. This poster will present the methodology used to in Wallonia. The methodology is based on 3 project rainfalls: 25, 50 and 100 years return period (consistency with the cartography of the

  7. USGS Training in Afghanistan: Modern Earthquake Hazards Assessments

    NASA Astrophysics Data System (ADS)

    Medlin, J. D.; Garthwaite, M.; Holzer, T.; McGarr, A.; Bohannon, R.; Bergen, K.; Vincent, T.

    2007-05-01

    Afghanistan is located in a tectonically active region where ongoing deformation has generated rugged mountainous terrain, and where large earthquakes occur frequently. These earthquakes can present a significant hazard, not only from strong ground shaking, but also from liquefaction and extensive land sliding. The magnitude 6.1 earthquake of March 25, 2002 highlighted the vulnerability of Afghanistan to such hazards, and resulted in over 1000 fatalities. The USGS has provided the first of a series of Earth Science training courses to the Afghan Geological Survey (AGS). This course was concerned with modern earthquake hazard assessments, and is an integral part of a larger USGS effort to provide a comprehensive seismic-hazard assessment for Afghanistan. Funding for these courses is provided by the US Agency for International Development Afghanistan Reconstruction Program. The particular focus of this training course, held December 2-6, 2006 in Kabul, was on providing a background in the seismological and geological methods relevant to preparing for future earthquakes. Topics included identifying active faults, modern tectonic theory, geotechnical measurements of near-surface materials, and strong-motion seismology. With this background, participants may now be expected to educate other members of the community and be actively involved in earthquake hazard assessments themselves. The December, 2006, training course was taught by four lecturers, with all lectures and slides being presented in English and translated into Dari. Copies of the lectures were provided to the students in both hardcopy and digital formats. Class participants included many of the section leaders from within the AGS who have backgrounds in geology, geophysics, and engineering. Two additional training sessions are planned for 2007, the first entitled "Modern Concepts in Geology and Mineral Resource Assessments," and the second entitled "Applied Geophysics for Mineral Resource Assessments."

  8. Toward Building a New Seismic Hazard Model for Mainland China

    NASA Astrophysics Data System (ADS)

    Rong, Y.; Xu, X.; Chen, G.; Cheng, J.; Magistrale, H.; Shen, Z.

    2015-12-01

    At present, the only publicly available seismic hazard model for mainland China was generated by Global Seismic Hazard Assessment Program in 1999. We are building a new seismic hazard model by integrating historical earthquake catalogs, geological faults, geodetic GPS data, and geology maps. To build the model, we construct an Mw-based homogeneous historical earthquake catalog spanning from 780 B.C. to present, create fault models from active fault data using the methodology recommended by Global Earthquake Model (GEM), and derive a strain rate map based on the most complete GPS measurements and a new strain derivation algorithm. We divide China and the surrounding regions into about 20 large seismic source zones based on seismotectonics. For each zone, we use the tapered Gutenberg-Richter (TGR) relationship to model the seismicity rates. We estimate the TGR a- and b-values from the historical earthquake data, and constrain corner magnitude using the seismic moment rate derived from the strain rate. From the TGR distributions, 10,000 to 100,000 years of synthetic earthquakes are simulated. Then, we distribute small and medium earthquakes according to locations and magnitudes of historical earthquakes. Some large earthquakes are distributed on active faults based on characteristics of the faults, including slip rate, fault length and width, and paleoseismic data, and the rest to the background based on the distributions of historical earthquakes and strain rate. We evaluate available ground motion prediction equations (GMPE) by comparison to observed ground motions. To apply appropriate GMPEs, we divide the region into active and stable tectonics. The seismic hazard will be calculated using the OpenQuake software developed by GEM. To account for site amplifications, we construct a site condition map based on geology maps. The resulting new seismic hazard map can be used for seismic risk analysis and management, and business and land-use planning.

  9. [Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria].

    PubMed

    Demin, O V; Gorianin, I I; Kholodenko, B N; Westerhoff, H V

    2001-01-01

    Direct nonenzymatic oxidation of semiquinone by oxygen is one of the main sources of superoxide radicals (O2.-) in mitochondria. By using all the known data on hepatocyte mitochondria, we have revealed the correlation between the rate of superoxide generation by the bc1 complex and the transmembrane potential (delta psi). If the main electrogenic stage of the Q cycle is suggested to be the electron transfer between the cytochrome b hemes, then the rate of superoxide generation sharply increases when delta psi grows from 150 mV to 180 mV. However, this interrelation is ambiguous. Indeed, the increase of the generation rate with the growth of the potential can occur faster when succinate dehydrogenase is inhibited by malonate than when external ADP is exhausted. When the potential is changed by adding phosphate or potassium (K+), the rate of O2.- production remains constant, although the comparison of the rate values at the same delta psi reveals the effect of phosphate or potassium. It turned out that the rate of O2.- generation is a function of delta mu H rather than any of its components. Phosphate and K+ have practically no influence on delta mu H, since the change in delta psi is compensated by delta pH. The rate of superoxide generation by the bc1 complex is a multiple function of the electron-transfer activity of enzymes, the processes determining the membrane potential (e.g., loading), and of the oxygen concentration. The kinetic model proposed in this work may serve a tool to understand how the superoxide production is regulated.

  10. Detection device for hazardous materials

    DOEpatents

    Partin, Judy K.; Grey, Alan E.

    1994-04-05

    A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  11. Detection device for hazardous material

    SciTech Connect

    Partin, J.K.; Grey, A.E.

    1990-12-31

    This invention is comprised of a detection device that is activated by the interaction of a hazardous chemical with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  12. Detection device for hazardous materials

    DOEpatents

    Partin, Judy K.; Grey, Alan E.

    1994-01-01

    A detection device that is activated by the interaction of a hazardous chcal with a coating interactive with said chemical on an optical fiber thereby reducing the amount of light passing through the fiber to a light detector. A combination of optical filters separates the light into a signal beam and a reference beam which after detection, appropriate amplification, and comparison with preset internal signals, activates an alarm means if a predetermined level of contaminant is observed.

  13. The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

    PubMed

    Vercruysse, Thomas; De Bie, Jolien; Neggers, Jasper E; Jacquemyn, Maarten; Vanstreels, Els; Schmid-Burgk, Jonathan L; Hornung, Veit; Baloglu, Erkan; Landesman, Yosef; Senapedis, William; Shacham, Sharon; Dagklis, Antonis; Cools, Jan; Daelemans, Dirk

    2016-10-25

    Purpose: Human exportin-1 (XPO1) is the key nuclear-cytoplasmic transport protein that exports different cargo proteins out of the nucleus. Inducing nuclear accumulation of these proteins by inhibiting XPO1 causes cancer cell death. First clinical validation of pharmacological inhibition of XPO1 was obtained with the Selective Inhibitor of Nuclear Export (SINE) compound selinexor (KPT-330) demonstrating activity in phase-II/IIb clinical trials when dosed 1 to 3 times weekly. The second-generation SINE compound KPT-8602 shows improved tolerability and can be dosed daily. Here, we investigate and validate the drug-target interaction of KPT-8602 and explore its activity against acute lymphoblastic leukemia (ALL).Experimental Design: We examined the effect of KPT-8602 on XPO1 function and XPO1-cargo as well as on a panel of leukemia cell lines. Mutant XPO1 leukemia cells were designed to validate KPT-8602's drug-target interaction. In vivo, anti-ALL activity was measured in a mouse ALL model and patient-derived ALL xenograft models.Results: KPT-8602 induced caspase-dependent apoptosis in a panel of leukemic cell lines in vitro Using CRISPR/Cas9 genome editing, we demonstrated the specificity of KPT-8602 for cysteine 528 in the cargo-binding groove of XPO1 and validated the drug target interaction. In vivo, KPT-8602 showed potent anti-leukemia activity in a mouse ALL model as well as in patient-derived T- and B-ALL xenograft models without affecting normal hematopoiesis.Conclusions: KPT-8602 is highly specific for XPO1 inhibition and demonstrates potent anti-leukemic activity supporting clinical application of the second-generation SINE compound for the treatment of ALL. Clin Cancer Res; 1-14. ©2016 AACR.

  14. Development of high flux thermal neutron generator for neutron activation analysis

    NASA Astrophysics Data System (ADS)

    Vainionpaa, Jaakko H.; Chen, Allan X.; Piestrup, Melvin A.; Gary, Charles K.; Jones, Glenn; Pantell, Richard H.

    2015-05-01

    The new model DD110MB neutron generator from Adelphi Technology produces thermal (<0.5 eV) neutron flux that is normally achieved in a nuclear reactor or larger accelerator based systems. Thermal neutron fluxes of 3-5 · 107 n/cm2/s are measured. This flux is achieved using four ion beams arranged concentrically around a target chamber containing a compact moderator with a central sample cylinder. Fast neutron yield of ∼2 · 1010 n/s is created at the titanium surface of the target chamber. The thickness and material of the moderator is selected to maximize the thermal neutron flux at the center. The 2.5 MeV neutrons are quickly thermalized to energies below 0.5 eV and concentrated at the sample cylinder. The maximum flux of thermal neutrons at the target is achieved when approximately half of the neutrons at the sample area are thermalized. In this paper we present simulation results used to characterize performance of the neutron generator. The neutron flux can be used for neutron activation analysis (NAA) prompt gamma neutron activation analysis (PGNAA) for determining the concentrations of elements in many materials. Another envisioned use of the generator is production of radioactive isotopes. DD110MB is small enough for modest-sized laboratories and universities. Compared to nuclear reactors the DD110MB produces comparable thermal flux but provides reduced administrative and safety requirements and it can be run in pulsed mode, which is beneficial in many neutron activation techniques.

  15. Sports: The Infectious Hazards.

    PubMed

    Minooee, Arezou; Wang, Jeff; Gupta, Geeta K

    2015-10-01

    Although the medical complications of sports are usually traumatic in nature, infectious hazards also arise. While blood-borne pathogens such as HIV, hepatitis B, and hepatitis C, cause significant illness, the risk of acquiring these agents during sporting activities is minimal. Skin infections are more commonplace, arising from a variety of microbial agents including bacterial, fungal, and viral pathogens. Sports involving water contact can lead to enteric infections, eye infections, or disseminated infections such as leptospirosis. Mumps, measles, and influenza are vaccine-preventable diseases that have been transmitted during sporting events, both in players and in spectators. Prevention is the key to many of these infections. Players should be vaccinated and should not participate in sports if their infection can be spread by contact, airborne, or droplet transmission.

  16. Motor Neurons Tune Premotor Activity in a Vertebrate Central Pattern Generator.

    PubMed

    Lawton, Kristy J; Perry, Wick M; Yamaguchi, Ayako; Zornik, Erik

    2017-03-22

    Central patterns generators (CPGs) are neural circuits that drive rhythmic motor output without sensory feedback. Vertebrate CPGs are generally believed to operate in a top-down manner in which premotor interneurons activate motor neurons that in turn drive muscles. In contrast, the frog (Xenopus laevis) vocal CPG contains a functionally unexplored neuronal projection from the motor nucleus to the premotor nucleus, indicating a recurrent pathway that may contribute to rhythm generation. In this study, we characterized the function of this bottom-up connection. The X. laevis vocal CPG produces a 50-60 Hz "fast trill" song used by males during courtship. We recorded "fictive vocalizations" in the in vitro CPG from the laryngeal nerve while simultaneously recording premotor activity at the population and single-cell level. We show that transecting the motor-to-premotor projection eliminated the characteristic firing rate of premotor neurons. Silencing motor neurons with the intracellular sodium channel blocker QX-314 also disrupted premotor rhythms, as did blockade of nicotinic synapses in the motor nucleus (the putative location of motor neuron-to-interneuron connections). Electrically stimulating the laryngeal nerve elicited primarily IPSPs in premotor neurons that could be blocked by a nicotinic receptor antagonist. Our results indicate that an inhibitory signal, activated by motor neurons, is required for proper CPG function. To our knowledge, these findings represent the first example of a CPG in which precise premotor rhythms are tuned by motor neuron activity.SIGNIFICANCE STATEMENT Central pattern generators (CPGs) are neural circuits that produce rhythmic behaviors. In vertebrates, motor neurons are not commonly known to contribute to CPG function, with the exception of a few spinal circuits where the functional significance of motor neuron feedback is still poorly understood. The frog hindbrain vocal circuit contains a previously unexplored connection from

  17. Characterization of sacral interneurons that mediate activation of locomotor pattern generators by sacrocaudal afferent input.

    PubMed

    Etlin, Alex; Finkel, Eran; Mor, Yoav; O'Donovan, Michael J; Anglister, Lili; Lev-Tov, Aharon

    2013-01-09

    Identification of the neural pathways involved in retraining the spinal central pattern generators (CPGs) by afferent input in the absence of descending supraspinal control is feasible in isolated rodent spinal cords where the locomotor CPGs are potently activated by sacrocaudal afferent (SCA) input. Here we study the involvement of sacral neurons projecting rostrally through the ventral funiculi (VF) in activation of the CPGs by sensory stimulation. Fluorescent labeling and immunostaining showed that VF neurons are innervated by primary afferents immunoreactive for vesicular glutamate transporters 1 and 2 and by intraspinal neurons. Calcium imaging revealed that 55% of the VF neurons were activated by SCA stimulation. The activity of VF neurons and the sacral and lumbar CPGs was abolished when non-NMDA receptors in the sacral segments were blocked by the antagonist CNQX. When sacral NMDA receptors were blocked by APV, the sacral CPGs were suppressed, VF neurons with nonrhythmic activity were recruited and a moderate-drive locomotor rhythm developed during SCA stimulation. In contrast, when the sacral CPGs were activated by SCA stimulation, rhythmic and nonrhythmic VF neurons were recruited and the locomotor rhythm was most powerful. The activity of 73 and 27% of the rhythmic VF neurons was in-phase with the ipsilateral and contralateral motor output, respectively. Collectively, our studies indicate that sacral VF neurons serve as a major link between SCA and the hindlimb CPGs and that the ability of SCA to induce stepping can be enhanced by the sacral CPGs. The nature of the ascending drive to lumbar CPGs, the identity of subpopulations of VF neurons, and their potential role in activating the locomotor rhythm are discussed.

  18. Transform-limited pulses generated by an actively Q-switched distributed fiber laser.

    PubMed

    Cuadrado-Laborde, C; Pérez-Millán, P; Andrés, M V; Díez, A; Cruz, J L; Barmenkov, Yu O

    2008-11-15

    A single-mode, transform-limited, actively Q-switched distributed-feedback fiber laser is presented, based on a new in-line acoustic pulse generator. Our technique permits a continuous adjustment of the repetition rate that modulates the Q factor of the cavity. Optical pulses of 800 mW peak power, 32 ns temporal width, and up to 20 kHz repetition rates were obtained. The measured linewidth demonstrates that these pulses are transform limited: 6 MHz for a train of pulses of 10 kHz repetition rate, 80 ns temporal width, and 60 mW peak power. Efficient excitation of spontaneous Brillouin scattering is demonstrated.

  19. Testing and Oxygen Assessment Results for a Next Generation Extravehicular Activity Portable Life Support System Fan

    NASA Technical Reports Server (NTRS)

    Paul, Heather L.; Jennings, Mallory A.; Rivera, Fatonia L.; Martin, Devin

    2011-01-01

    NASA is designing a next generation Extravehicular Activity (EVA) Portable Life Support System (PLSS) for use in future surface exploration endeavors. To meet the new requirements for ventilation flow at nominal and buddy modes, a fan has been developed and tested. This paper summarizes the results of the performance and life cycle testing efforts conducted at the NASA Johnson Space Center. Additionally, oxygen compatibility assessment results from an evaluation conducted at White Sands Test Facility (WSTF) are provided, and lessons learned and future recommendations are outlined.

  20. Automation of labelling of Lipiodol with high-activity generator-produced 188Re.

    PubMed

    Lepareur, Nicolas; Ardisson, Valérie; Noiret, Nicolas; Boucher, Eveline; Raoul, Jean-Luc; Clément, Bruno; Garin, Etienne

    2011-02-01

    This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol ((188)Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).

  1. Active force generation in cross-linked filament bundles without motor proteins.

    PubMed

    Walcott, Sam; Sun, Sean X

    2010-11-01

    Cytoskeletal filaments often interact laterally through cross-linking proteins, contributing to passive cellular viscoelasticity and, perhaps surprisingly, active force generation. We present a theory, based on the formation and rupture of cross-linker bonds, that relates molecular properties of those interactions to the macroscale mechanics of filament bundles. Computing the force-velocity relation for such a bundle, we demonstrate significant contractile forces in the absence of molecular motors. This theory provides insight into cytokinesis, cytoskeletal mechanics, and stress-fiber contraction.

  2. Alliinase from Ensifer adhaerens and Its Use for Generation of Fungicidal Activity

    PubMed Central

    2011-01-01

    A bacterium Ensifer adhaerens FERM P-19486 with the ability of alliinase production was isolated from a soil sample. The enzyme was purified for characterization of its general properties and evaluation of its application in on-site production of allicin-dependent fungicidal activity. The bacterial alliinase was purified 300-fold from a cell-free extract, giving rise to a homogenous protein band on polyacrylamide gel electrophoresis. The bacterial alliinase (96 kDa) consisted of two identical subunits (48 kDa), and was most active at 60°C and at pH 8.0. The enzyme stoichiometrically converted (-)-alliin ((-)-S-allyl-L-cysteine sulfoxide) to form allicin, pyruvic acid, and ammonia more selectively than (+)-alliin, a naturally occurring substrate for plant alliinase ever known. The C-S lyase activity was also detected with this bacterial enzyme when S-alkyl-L-cysteine was used as a substrate, though such a lyase activity is absolutely absent in alliinase of plant origin. The enzyme generated a fungicidal activity against Saccharomyces cerevisiae in a time- and a dose-dependent fashion using alliin as a stable precursor. Alliinase of Ensifer adhaerens FERM P-19486 is the enzyme with a novel type of substrate specificity, and thus considered to be beneficial when used in combination with garlic enzyme with respect to absolute conversion of (±)-alliin to allicin. PMID:21906328

  3. Efficient peroxydisulfate activation process not relying on sulfate radical generation for water pollutant degradation.

    PubMed

    Zhang, Tao; Chen, Yin; Wang, Yuru; Le Roux, Julien; Yang, Yang; Croué, Jean-Philippe

    2014-05-20

    Peroxydisulfate (PDS) is an appealing oxidant for contaminated groundwater and toxic industrial wastewaters. Activation of PDS is necessary for application because of its low reactivity. Present activation processes always generate sulfate radicals as actual oxidants which unselectively oxidize organics and halide anions reducing oxidation capacity of PDS and producing toxic halogenated products. Here we report that copper oxide (CuO) can efficiently activate PDS under mild conditions without producing sulfate radicals. The PDS/CuO coupled process is most efficient at neutral pH for decomposing a model compound, 2,4-dichlorophenol (2,4-DCP). In a continuous-flow reaction with an empty-bed contact time of 0.55 min, over 90% of 2,4-DCP (initially 20 μM) and 90% of adsorbable organic chlorine (AOCl) can be removed at the PDS/2,4-DCP molar ratio of 1 and 4, respectively. Based on kinetic study and surface characterization, PDS is proposed to be first activated by CuO through outer-sphere interaction, the rate-limiting step, followed by a rapid reaction with 2,4-DCP present in the solution. In the presence of ubiquitous chloride ions in groundwater/industrial wastewater, the PDS/CuO oxidation shows significant advantages over sulfate radical oxidation by achieving much higher 2,4-DCP degradation capacity and avoiding the formation of highly chlorinated degradation products. This work provides a new way of PDS activation for contaminant removal.

  4. Optimizing for generalization in the decoding of internally generated activity in the hippocampus.

    PubMed

    van der Meer, Matthijs A A; Carey, Alyssa A; Tanaka, Youki

    2017-02-08

    The decoding of a sensory or motor variable from neural activity benefits from a known ground truth against which decoding performance can be compared. In contrast, the decoding of covert, cognitive neural activity, such as occurs in memory recall or planning, typically cannot be compared to a known ground truth. As a result, it is unclear how decoders of such internally generated activity should be configured in practice. We suggest that if the true code for covert activity is unknown, decoders should be optimized for generalization performance using cross-validation. Using ensemble recording data from hippocampal place cells, we show that this cross-validation approach results in different decoding error, different optimal decoding parameters, and different distributions of error across the decoded variable space. In addition, we show that a minor modification to the commonly used Bayesian decoding procedure, which enables the use of spike density functions, results in substantially lower decoding errors. These results have implications for the interpretation of covert neural activity, and suggest easy-to-implement changes to commonly used procedures across domains, with applications to hippocampal place cells in particular. © 2017 Wiley Periodicals, Inc.

  5. Determination of specific activity of (226)Ra, (232)Th and (40)K for assessment of radiation hazards from Turkish pumice samples.

    PubMed

    Turhan, Seref; Gündüz, Lüfullah

    2008-02-01

    The specific activity of (226)Ra, (232)Th and (40)K in 52 Turkish pumice samples collected from 11 geographical areas located in Central Anatolia, Eastern Anatolia, Mediterranean and Aegean regions was determined by gamma-ray spectrometry with a high-purity germanium (HPGe) detector. The specific activity of (226)Ra, (232)Th and (40)K ranged from 12.7+/-0.5 to 256.2+/-9.1Bqkg(-1) with a mean of 89.1+/-65.2Bqkg(-1), 12.3+/-1.0 to 237.9+/-12.2Bqkg(-1) with a mean of 87.0+/-61.4Bqkg(-1) and 300.1+/-5.5 to 1899.0+/-30.8Bqkg(-1) with a mean of 1211.9+/-419.8Bqkg(-1), respectively. Elemental concentrations were determined for U (from 1.0 to 20.7ppm with a mean of 7.2+/-5.3ppm), Th (from 3.0 to 58.6ppm with a mean of 21.4+/-15.1ppm) and K (from 1.0 to 6.1% with a mean of 3.9+/-1.3%). The radium equivalent activity (Ra(eq)), the activity index, the emanation coefficient, the (222)Rn mass exhalation rate, the indoor absorbed dose rate and the effective dose rate were estimated for the radiation hazard of the natural radioactivity in all samples. The calculated mean Ra(eq) value was 306.6+/-177.7Bqkg(-1) (54.6+/-5.5 to 737.6+/-49.0Bqkg(-1)) for all pumice samples. This value is lower than the recommended limit value of 370Bqkg(-1) for building raws and products. The emanation coefficient and the (222)Rn mass exhalation rate of all samples ranged from 29.4 to 42.9% with a mean of 36.2% and from 11.0 to 196.4microBqkg(-1)s(-1) with a mean of 73.5microBqkg(-1)s(-1), respectively. The mean indoor absorbed dose rate and the corresponding mean effective dose rate were 274.6+/-153.6nGyh(-1) (50.4-644.6nGyh(-1)) and 1.35+/-0.75mSvy(-1) (0.24-3.16mSvy(-1)), respectively. For all pumice samples the mean indoor absorbed dose rate is about three times higher than the population-weighted average of 84nGyh(-1), while the mean effective dose rate values except for PUM 05, PUM 06, PUM 10 and PUM 15 exceed the dose criterion of 1mSvy(-1).

  6. Generation of knockout rabbits using transcription activator-like effector nucleases.

    PubMed

    Wang, Yu; Fan, Nana; Song, Jun; Zhong, Juan; Guo, Xiaogang; Tian, Weihua; Zhang, Quanjun; Cui, Fenggong; Li, Li; Newsome, Philip N; Frampton, Jon; Esteban, Miguel A; Lai, Liangxue

    2014-01-01

    Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platforms contributing to redefine the boundaries of modern biological research. They are composed of a non-specific cleavage domain and a tailor made DNA-binding module, which enables a broad range of genetic modifications by inducing efficient DNA double-strand breaks at desired loci. Among other remarkable uses, these nucleases have been employed to produce gene knockouts in mid-size and large animals, such as rabbits and pigs, respectively. This approach is cost effective, relatively quick, and can produce invaluable models for human disease studies, biotechnology or agricultural purposes. Here we describe a protocol for the efficient generation of knockout rabbits using transcription activator-like effector nucleases, and a perspective of the field.

  7. Experiments and modelling of active quasi-single helicity regime generation in a reversed field pinch

    NASA Astrophysics Data System (ADS)

    Frassinetti, L.; Brunsell, P. R.; Drake, J. R.

    2009-07-01

    The interaction of a static resonant magnetic perturbation (RMP) with a tearing mode (TM) is becoming a relevant topic in fusion plasma physics. RMPs can be generated by active coils and then used to affect the properties of TMs and of the corresponding magnetic islands. This paper shows how the feedback system of the EXTRAP T2R reversed field pinch (RFP) can produce a RMP that affects a rotating TM and stimulate the transition to the so-called quasi-single helicity (QSH) regime, a RFP plasma state characterized by a magnetic island surrounded by low magnetic chaos. The application of the RMP can increase the QSH probability up to 10% and enlarge the size of the corresponding island. Part of the experimental results are supported by a theoretical study that models the effect of the active coils on the magnetic island.

  8. Multicomponent, Mannich-type assembly process for generating novel, biologically-active 2-arylpiperidines and derivatives

    PubMed Central

    Hardy, Simon; Martin, Stephen F.

    2014-01-01

    A multicomponent, Mannich-type assembly process commencing with commercially available bromobenzaldehydes was sequenced with [3+2] dipolar cycloaddition reactions involving nitrones and azomethine ylides to generate collections of fused, bicyclic scaffolds based on the 2-arylpiperidine subunit. Use of the 4-pentenoyl group, which served both as an activator in the Mannich-type reaction and a readily-cleaved amine protecting group, allowed sub-libraries to be prepared through piperidine N-functionalization and cross-coupling of the aryl bromide. A number of these derivatives displayed biological activities that had not previously been associated with this substructure. Methods were also developed that allowed rapid conversion of these scaffolds to novel, polycyclic dihydroquinazolin-2-ones, 2-imino-1,3-benzothiazinanes, dihydroisoquinolin-3-ones and bridged tetrahydroquinolines. PMID:25267860

  9. Thermal design and development of actively cooled brushes for compact homopolar generators

    NASA Astrophysics Data System (ADS)

    Makel, D. B.

    1986-11-01

    The thermal and hydraulic design of actively cooled current transfer brushes for compact homopolar generators (HPG) is described. The development of high-energy-density HPG's at the Center for Electromechanics at the University of Texas at Austin requires brushgear capable of handling high current densities and large thermal loads. Platelet technology has been applied in the design of actively cooled brushes with coolant injection directly from the brush contact face into the brush-rotor interface. Coolant channels a few thousandths of an inch in diameter have been designed in brushes constructed of photoetched platelets of copper (0.020 to 0.005 in. thick) and then bonded to form the cooled brush. Platelet construction of brushes also permits the incorporation of internal instrumentation for temperature measurement. The brushes have been designed to provide data on the effects of rotor speed, current level, coolant flow rate, and coolant injection pattern.

  10. Wake-Vortex Hazards During Cruise

    NASA Technical Reports Server (NTRS)

    Rossow, Vernon J.; James, Kevin D.; Nixon, David (Technical Monitor)

    1998-01-01

    Even though the hazard posed by lift-generated wakes of subsonic transport aircraft has been studied extensively for approach and departure at airports, only a small amount of effort has gone into the potential hazard at cruise altitude. This paper reports on a studio of the wake-vortex hazard during cruise because encounters may become more prevalent when free-flight becomes available and each aircraft, is free to choose its own route between destinations. In order to address the problem, the various fluid-dynamic stages that vortex wakes usually go through as they age will be described along with estimates of the potential hazard that each stage poses. It appears that a rolling-moment hazard can be just as severe at cruise as for approach at airports, but it only persists for several minutes. However, the hazard posed by the downwash in the wake due to the lift on the generator aircraft persists for tens of minutes in a long narrow region behind the generating aircraft. The hazard consists of severe vertical loads when an encountering aircraft crosses the wake. A technique for avoiding vortex wakes at cruise altitude will be described. To date the hazard posed by lift-generated vortex wakes and their persistence at cruise altitudes has been identified and subdivided into several tasks. Analyses of the loads to be encounter and are underway and should be completed shortly. A review of published literature on the subject has been nearly completed (see text) and photographs of vortex wakes at cruise altitudes have been taken and the various stages of decay have been identified. It remains to study and sort the photographs for those that best illustrate the various stages of decay after they are shed by subsonic transport aircraft at cruise altitudes. The present status of the analysis and the paper are described.

  11. Using Electronic Neutron Generators in Active Interrogation to Detect Shielded Fissionable Material

    SciTech Connect

    D. L. Chichester; E. H. Seabury

    2008-10-01

    Experiments have been performed at Idaho National Laboratory to study methodology and instrumentation for performing neutron active interrogation die-away analyses for the purpose of detecting shielded fissionable material. Here we report initial work using a portable DT electronic neutron generator with a He-3 fast neutron detector to detect shielded fissionable material including >2 kg quantities of enriched uranium and plutonium. Measurements have been taken of bare material as well as of material hidden within a large plywood cube. Results from this work have demonstrated the efficacy of the die-away neutron measurement technique for quickly detecting the presence of special nuclear material hidden within plywood shields by analyzing the time dependent neutron signals in-between neutron generator pulses. Using a DT electronic neutron generator operating at 300 Hz with a yield of approximately 0.36 x 10**8 neutrons per second, 2.2 kg of enriched uranium hidden within a 0.60 m x 0.60 m x 0.70 m volume of plywood was positively detected with a measurement signal 2-sigma above the passive background within 1 second. Similarly, for a 500 second measurement period a lower detection limit of approaching the gram level could be expected with the same simple set-up.

  12. Putative role of border cells in generating spontaneous morphological activity within Kölliker's organ.

    PubMed

    Dayaratne, M W Nishani; Vlajkovic, Srdjan M; Lipski, Janusz; Thorne, Peter R

    2015-12-01

    Kölliker's organ is a transient epithelial structure, comprising a major part of the organ of Corti during pre-hearing stages of development. The auditory system is spontaneously active during development, which serves to retain and refine neural connections. Kölliker's organ is considered a key candidate for generating such spontaneous activity, most likely through purinergic (P2 receptor) signalling and inner hair cell (IHC) activation. Associated with the spontaneous neural activity, ATP released locally by epithelial cells induces rhythmic morphological changes within Kölliker's organ, the purpose of which is not understood. These changes are accompanied by a shift in cellular refractive index, allowing optical detection of this activity in real-time. Using this principle, we investigated the origin of spontaneous morphological activity within Kölliker's organ. Apical turns of Wistar rat cochleae (P9-11) were dissected, and the purinergic involvement was studied following acute tissue exposure to a P2 receptor agonist (ATPγS) and antagonist (suramin). ATPγS induced a sustained darkening throughout Kölliker's organ, reversed by suramin. This effect was most pronounced in the region closest to the inner hair cells, which also displayed the highest frequency of intrinsic morphological events. Additionally, suramin alone induced swelling of this region, suggesting a tight regulation of cell volume by ATP-mediated mechanisms. Histological analysis of cochlear tissues demonstrates the most profound volume changes in the border cell region immediately adjacent to the IHCs. Together, these results underline the role of purinergic signalling in initiating morphological events within Kölliker's organ, and suggest a key involvement of border cells surrounding IHCs in regulating this spontaneous activity.

  13. A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight.

    PubMed

    Buhl, Edgar; Schildberger, Klaus; Stevenson, Paul A

    2008-07-01

    A central question in behavioural control is how central pattern generators (CPGs) for locomotion are activated. This paper disputes the key role generally accredited to octopamine in activating the CPG for insect flight. In deafferented locusts, fictive flight was initiated by bath application of the muscarinic agonist pilocarpine, the acetylcholine analogue carbachol, and the acetylcholinesterase blocker eserine, but not by nicotine. Furthermore, in addition to octopamine, various other amines including dopamine, tyramine and histamine all induced fictive flight, but not serotonin or the amine-precursor amino acid tyrosine. However, flight initiation was not reversibly blocked by aminergic antagonists, and was still readily elicited by both natural stimulation (wind) and pilocarpine in reserpinized, amine-depleted locusts. By contrast, the muscarinic antagonists atropine and scopolamine reversibly blocked flight initiated by wind, cholinergic agonists, octopamine, and by selective stimulation of a flight-initiating interneurone (TCG). The short delay from TCG stimulation to flight onset suggests that TCG acts directly on the flight CPG, and accordingly that TCG, or its follower cell within the flight generating circuit, is cholinergic. We conclude that acetylcholine acting via muscarinic receptors is the key neurotransmitter in the mechanism underlying the natural activation of the locust flight CPG. Amines are not essential for this, but must be considered as potential neuromodulators for facilitating flight release and tuning the motor pattern. We speculate that muscarinic activation coupled to aminergic facilitation may be a general feature of behavioural control in insects for ensuring conditional recruitment of individual motor programs in accordance with momentary adaptive requirements.

  14. Diosgenin inhibits superoxide generation in FMLP-activated mouse neutrophils via multiple pathways.

    PubMed

    Lin, Y; Jia, R; Liu, Y; Gao, Y; Zeng, X; Kou, J; Yu, B

    2014-12-01

    Diosgenin possesses anti-inflammatory and anticancer properties. Activated neutrophils produce high concentrations of the superoxide anion which is involved in the pathophysiology of inflammation-related diseases and cancer. In the present study, the inhibitory effect and possible mechanisms of diosgenin on superoxide generation were investigated in mouse bone marrow neutrophils. Diosgenin potently and concentration-dependently inhibited the extracellular and intracellular superoxide anion generation in Formyl-Met-Leu-Phe (FMLP)- activated neutrophils, with IC50 values of 0.50 ± 0.08 μM and 0.66 ± 0.13 μM, respectively. Such inhibition was not mediated by scavenging the superoxide anion or by a cytotoxic effect. Diosgenin inhibited the phosphorylation of p47phox and membrane translocation of p47phox and p67phox, and thus blocking the assembly of nicotinamide adenine dinucleotide phosphate oxidase. Moreover, cellular cyclic adenosine monophosphate (cAMP) levels and protein kinase A (PKA) expression were also effectively increased by diosgenin. It attenuated FMLP-induced increase of phosphorylation of cytosolic phospholipase A (cPLA2), p21-activated kinase (PAK), Akt, p38 mitogen-activated protein kinase (p38MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK). Our data indicate that diosgenin exhibits inhibitory effects on superoxide anion production through the blockade of cAMP, PKA, cPLA2, PAK, Akt and MAPKs signaling pathways. The results may explain the clinical implications of diosgenin in the treatment of inflammation-related disorders.

  15. Ground-based acoustic parametric generator impact on the atmosphere and ionosphere in an active experiment

    NASA Astrophysics Data System (ADS)

    Rapoport, Yuriy G.; Cheremnykh, Oleg K.; Koshovy, Volodymyr V.; Melnik, Mykola O.; Ivantyshyn, Oleh L.; Nogach, Roman T.; Selivanov, Yuriy A.; Grimalsky, Vladimir V.; Mezentsev, Valentyn P.; Karataeva, Larysa M.; Ivchenko, Vasyl. M.; Milinevsky, Gennadi P.; Fedun, Viktor N.; Tkachenko, Eugen N.

    2017-01-01

    We develop theoretical basics of active experiments with two beams of acoustic waves, radiated by a ground-based sound generator. These beams are transformed into atmospheric acoustic gravity waves (AGWs), which have parameters that enable them to penetrate to the altitudes of the ionospheric E and F regions where they influence the electron concentration of the ionosphere. Acoustic waves are generated by the ground-based parametric sound generator (PSG) at the two close frequencies. The main idea of the experiment is to design the output parameters of the PSG to build a cascade scheme of nonlinear wave frequency downshift transformations to provide the necessary conditions for their vertical propagation and to enable penetration to ionospheric altitudes. The PSG generates sound waves (SWs) with frequencies f1 = 600 and f2 = 625 Hz and large amplitudes (100-420 m s-1). Each of these waves is modulated with the frequency of 0.016 Hz. The novelty of the proposed analytical-numerical model is due to simultaneous accounting for nonlinearity, diffraction, losses, and dispersion and inclusion of the two-stage transformation (1) of the initial acoustic waves to the acoustic wave with the difference frequency Δf = f2 - f1 in the altitude ranges 0-0.1 km, in the strongly nonlinear regime, and (2) of the acoustic wave with the difference frequency to atmospheric acoustic gravity waves with the modulational frequency in the altitude ranges 0.1-20 km, which then reach the altitudes of the ionospheric E and F regions, in a practically linear regime. AGWs, nonlinearly transformed from the sound waves, launched by the two-frequency ground-based sound generator can increase the transparency of the ionosphere for the electromagnetic waves in HF (MHz) and VLF (kHz) ranges. The developed theoretical model can be used for interpreting an active experiment that includes the PSG impact on the atmosphere-ionosphere system, measurements of electromagnetic and acoustic fields, study of

  16. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing... rebuttable presumption for used oil of § 279.10(b)(1)(ii) applies to used oil managed by generators....

  17. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing... rebuttable presumption for used oil of § 279.10(b)(1)(ii) applies to used oil managed by generators....

  18. Human cervical spinal cord circuitry activated by tonic input can generate rhythmic arm movements.

    PubMed

    Solopova, I A; Selionov, V A; Zhvansky, D S; Gurfinkel, V S; Ivanenko, Y

    2016-02-01

    The coordination between arms and legs during human locomotion shares many features with that in quadrupeds, yet there is limited evidence for the central pattern generator for the upper limbs in humans. Here we investigated whether different types of tonic stimulation, previously used for eliciting stepping-like leg movements, may evoke nonvoluntary rhythmic arm movements. Twenty healthy subjects participated in this study. The subject was lying on the side, the trunk was fixed, and all four limbs were suspended in a gravity neutral position, allowing unrestricted low-friction limb movements in the horizontal plane. The results showed that peripheral sensory stimulation (continuous muscle vibration) and central tonic activation (postcontraction state of neuronal networks following a long-lasting isometric voluntary effort, Kohnstamm phenomenon) could evoke nonvoluntary rhythmic arm movements in most subjects. In ∼40% of subjects, tonic stimulation elicited nonvoluntary rhythmic arm movements together with rhythmic movements of suspended legs. The fact that not all participants exhibited nonvoluntary limb oscillations may reflect interindividual differences in responsiveness of spinal pattern generation circuitry to its activation. The occurrence and the characteristics of induced movements highlight the rhythmogenesis capacity of cervical neuronal circuitries, complementing the growing body of work on the quadrupedal nature of human gait.

  19. Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase.

    PubMed

    Morgan, Lloyd T; Thomas, Christopher P; Kühn, Hartmut; O'Donnell, Valerie B

    2010-10-01

    Arachidonate-containing oxidized phospholipids are acutely generated by 12-LOX (12-lipoxygenase) in agonist-activated platelets. In the present study, formation of structurally related lipids by oxidation of DHA (docosahexaenoic acid)-containing phospholipids is demonstrated using lipidomic approaches. Precursor scanning reverse-phase LC (liquid chromatography)-MS/MS (tandem MS) identified a new family of lipids that comprise phospholipid-esterified HDOHE (hydroxydocosahexaenoic acid). Two diacyl and two plasmalogen PEs (phosphatidylethanolamines) containing predominantly the 14-HDOHE positional isomer (18:0p/14-HDOHE-PE, 18:0a/14-HDOHE-PE, 16:0a/14-HDOHE-PE and 16:0p/14-HDOHE-PE) were structurally characterized using MS/MS and by comparison with biogenic standards. An involvement of 12-LOX was indicated as purified recombinant human 12-LOX also generated the 14-HDOHE isomer from DHA. Pharmacological studies using inhibitors and recombinant platelet 12-LOX indicate that they form via esterification of newly formed non-esterified HDOHE. HDOHE-PEs formed at significant rates (2-4 ng/4×10(7) cells) within 2-180 min of thrombin stimulation, and their formation was blocked by calcium chelation. In summary, a new family of oxidized phospholipid was identified in thrombin-activated human platelets.

  20. Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation.

    PubMed

    van Weelden, Susanne W H; Fast, Beate; Vogt, Achim; van der Meer, Pieter; Saas, Joachim; van Hellemond, Jaap J; Tielens, Aloysius G M; Boshart, Michael

    2003-04-11

    The importance of a functional Krebs cycle for energy generation in the procyclic stage of Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth of a pleomorphic parasite strain. Wild type procyclic cells and mutants with targeted deletion of the gene coding for aconitase were derived by synchronous in vitro differentiation from wild type and mutant (Delta aco::NEO/Delta aco::HYG) bloodstream stage parasites, respectively, where aconitase is not expressed and is dispensable. No differences in intracellular levels of glycolytic and Krebs cycle intermediates were found in procyclic wild type and mutant cells, except for citrate that accumulated up to 90-fold in the mutants, confirming the absence of aconitase activity. Surprisingly, deletion of aconitase did not change differentiation nor the growth rate or the intracellular ATP/ADP ratio in those cells. Metabolic studies using radioactively labeled substrates and NMR analysis demonstrated that glucose and proline were not degraded via the Krebs cycle to CO(2). Instead, glucose was degraded to acetate, succinate, and alanine, whereas proline was degraded to succinate. Importantly, there was absolutely no difference in the metabolic products released by wild type and aconitase knockout parasites, and both were for survival strictly dependent on respiration via the mitochondrial electron transport chain. Hence, although the Krebs cycle enzymes are present, procyclic T. brucei do not use Krebs cycle activity for energy generation, but the mitochondrial respiratory chain is essential for survival and growth. We therefore propose a revised model of the energy metabolism of procyclic T. brucei.