Science.gov

Sample records for activities provide opportunities

  1. EDUCATIONAL OPPORTUNITIES PROVIDED BY COMMUNITY ACTION PROGRAMS.

    ERIC Educational Resources Information Center

    PINNOCK, THEODORE J.

    INFORMAL EDUCATION PRIMARILY INCLUDES EDUCATION FOR EVERYDAY EFFECTIVE LIVING AND DOES NOT NECESSARILY HAVE TO INCLUDE COURSES FOR CREDIT AT THE HIGH SCHOOL AND COLLEGE LEVELS. MILLIONS OF POVERTY STRICKEN PEOPLE CAN BENEFIT FROM THE TYPE OF INFORMAL EDUCATION PROVIDED THROUGH THE OFFICE OF ECONOMIC OPPORTUNITY (OEO) IN SUCH PROGRAMS AS--(1) THE…

  2. GEAR UP: Providing Opportunities or Conflict?

    ERIC Educational Resources Information Center

    Walsh, Rachael

    2008-01-01

    Since 1965 the federal government has attempted to provide low socioeconomic status students with equal access to postsecondary education through the Higher Education Act and its multiplicative programmatic efforts. Implemented as one such program in 1998, the Gaining Early Awareness and Readiness for Undergraduate Programs, or GEAR UP, has been…

  3. Physical activity opportunities in afterschool programs

    PubMed Central

    Weaver, R. Glenn; Beets, Michael W.; Huberty, Jennifer; Freedman, Darcy; Turner-Mcgrievy, Gabrielle; Ward, Diane

    2015-01-01

    Afterschool programs (ASPs) have potential to provide children moderate-to-vigorous physical activity (MVPA). The availability and types (e.g., free play or organized activities) of physical activity opportunities, their structure (e.g., presence of lines, elimination games), and staff behaviors (e.g., encouragement, engaged) can influence children’s MVPA. This study explored these factors in 20 ASPs serving over 1,700 elementary-age children. The occurrence, types and structure of physical activity opportunities, and staff behaviors were collected via the System for Observing Staff Promotion of Physical Activity and Nutrition (SOSPAN). A total of 4,660 SOSPAN scans were completed across 63 complete program days (1733 during physical activity opportunities). Physical activity opportunities were observed on 60 program days across all 20 sites, with 73% of those opportunities classified as free play. ASPs scheduled an average of 66.3 minutes (range 15-150min) of physical activity opportunities daily. Games played included basketball, tag, soccer and football. Staff rarely engaged in physical activity promotion behaviors, and the structure of organized games discouraged MVPA. For example, staff verbally promoted physical activity in just 6.1% of scans, while organized games were more likely to involve lines and elimination. Professional development training may enhance staffs’ physical activity promotion and the structure of activity opportunities. PMID:25586132

  4. Physical activity opportunities in afterschool programs.

    PubMed

    Weaver, R Glenn; Beets, Michael W; Huberty, Jennifer; Freedman, Darcy; Turner-Mcgrievy, Gabrielle; Ward, Diane

    2015-05-01

    Afterschool programs (ASPs) have potential to provide children moderate to vigorous physical activity (MVPA). The availability and types (e.g., free play or organized activities) of physical activity opportunities, their structure (e.g., presence of lines, elimination games), and staff behaviors (e.g., encouragement, engaged) can influence children's MVPA. This study explored these factors in 20 ASPs serving over 1,700 elementary-age children. The occurrence, types, and structure of physical activity opportunities, and staff behaviors were collected via the SOSPAN (System for Observing Staff Promotion of Physical Activity and Nutrition). A total of 4,660 SOSPAN scans were completed across 63 complete program days (1,733 during physical activity opportunities). Physical activity opportunities were observed on 60 program days across all 20 sites, with 73% of those opportunities classified as free play. ASPs scheduled an average of 66.3 minutes (range 15-150 minutes) of physical activity opportunities daily. Games played included basketball, tag, soccer, and football. Staff rarely engaged in physical activity promotion behaviors, and the structure of organized games discouraged MVPA. For example, staff verbally promoted physical activity in just 6.1% of scans, while organized games were more likely to involve lines and elimination. Professional development training may enhance staffs' physical activity promotion and the structure of activity opportunities. PMID:25586132

  5. Physical activity opportunities in afterschool programs.

    PubMed

    Weaver, R Glenn; Beets, Michael W; Huberty, Jennifer; Freedman, Darcy; Turner-Mcgrievy, Gabrielle; Ward, Diane

    2015-05-01

    Afterschool programs (ASPs) have potential to provide children moderate to vigorous physical activity (MVPA). The availability and types (e.g., free play or organized activities) of physical activity opportunities, their structure (e.g., presence of lines, elimination games), and staff behaviors (e.g., encouragement, engaged) can influence children's MVPA. This study explored these factors in 20 ASPs serving over 1,700 elementary-age children. The occurrence, types, and structure of physical activity opportunities, and staff behaviors were collected via the SOSPAN (System for Observing Staff Promotion of Physical Activity and Nutrition). A total of 4,660 SOSPAN scans were completed across 63 complete program days (1,733 during physical activity opportunities). Physical activity opportunities were observed on 60 program days across all 20 sites, with 73% of those opportunities classified as free play. ASPs scheduled an average of 66.3 minutes (range 15-150 minutes) of physical activity opportunities daily. Games played included basketball, tag, soccer, and football. Staff rarely engaged in physical activity promotion behaviors, and the structure of organized games discouraged MVPA. For example, staff verbally promoted physical activity in just 6.1% of scans, while organized games were more likely to involve lines and elimination. Professional development training may enhance staffs' physical activity promotion and the structure of activity opportunities.

  6. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Providing other economic opportunities. 135.40 Section 135.40 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN...

  7. Physical Activity Opportunities before and after School

    ERIC Educational Resources Information Center

    Hastie, Peter A.

    2007-01-01

    This article addresses the many ways in which schools can provide physical activity opportunities for students by taking advantage of hours that students might otherwise spend waiting for school to begin or playing computer games after school has ended. The article presents creative strategies for engaging students in activities that are…

  8. How an Intranet Provides Opportunities for Learning Organizational Culture

    ERIC Educational Resources Information Center

    Bennett, Elisabeth E.

    2007-01-01

    This paper discusses a qualitative case study that addresses how an intranet can provide opportunities for learning about an organization's culture. Four primary findings are discussed with the study concluding that cultural knowledge is conveyed and renewed through an intranet in a learning process that emphasizes informal learning and…

  9. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and use of procedures under 24 CFR part 963 regarding HA contracts to HA resident-owned businesses. A... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Providing other economic opportunities. 135.40 Section 135.40 Housing and Urban Development Regulations Relating to Housing and...

  10. Hydrogen PEM Fuel Cells: A Market Need Provides Research Opportunities

    SciTech Connect

    Payne, Terry L; Brown, Gilbert M; Bogomolny, David

    2010-01-01

    It has been said that necessity is the mother of invention. Another way this can be stated is that market demands create research opportunities. Because of the increasing demand for oil (especially for fueling vehicles utilizing internal combustion engines) and the fact that oil is a depleting (not renewable) energy source, a market need for a renewable source of energy has created significant opportunities for research. This paper addresses the research opportunities associated with producing a market competitive (i.e., high performance, low cost and durable) hydrogen proton exchange membrane (PEM) fuel cell. Of the many research opportunities, the primary ones to be addressed directly are: Alternative membrane materials, Alternative catalysts, Impurity effects, and Water transport. A status of Department of Energy-sponsored research in these areas will be summarized and the impact of each on the ability to develop a market-competitive hydrogen PEM fuel cell powered vehicle will be discussed. Also, activities of the International Partnership for the Hydrogen Economy in areas such as advanced membranes for fuel cells and materials for storage will be summarized.

  11. Enhancing Academic Engagement: Providing Opportunities for Responding and Influencing Students to Choose to Respond

    ERIC Educational Resources Information Center

    Skinner, Christopher H.; Pappas, Danielle N.; Davis, Kai A.

    2005-01-01

    Although educators often provide opportunities for students to engage in active academic responding, in many situations, students either cannot or will not respond. In the current article, we analyze the reasons students fail to respond. Practical procedures educators can use to prevent "can't do" problems are provided. "Won't do" problems are…

  12. Precision medicine: opportunities, possibilities, and challenges for patients and providers.

    PubMed

    Adams, Samantha A; Petersen, Carolyn

    2016-07-01

    Precision medicine approaches disease treatment and prevention by taking patients' individual variability in genes, environment, and lifestyle into account. Although the ideas underlying precision medicine are not new, opportunities for its more widespread use in practice have been enhanced by the development of large-scale databases, new methods for categorizing and representing patients, and computational tools for analyzing large datasets. New research methods may create uncertainty for both healthcare professionals and patients. In such situations, frameworks that address ethical, legal, and social challenges can be instrumental for facilitating trust between patients and providers, but must protect patients while not stifling progress or overburdening healthcare professionals. In this perspective, we outline several ethical, legal, and social issues related to the Precision Medicine Initiative's proposed changes to current institutions, values, and frameworks. This piece is not an exhaustive overview, but is intended to highlight areas meriting further study and action, so that precision medicine's goal of facilitating systematic learning and research at the point of care does not overshadow healthcare's goal of providing care to patients.

  13. Scientific advances provide opportunities to improve pediatric environmental health

    USGS Publications Warehouse

    Reddy, Michael M.; Reddy, Micaela B.; Reddy, Carol F.

    2004-01-01

    The health consequences of contaminants in the environment, with respect to the health of children and infants, recently have been dramatically brought to public attention by the motion pictures Erin Brockovich and A Civil Action. These productions focused public attention on the potential link between water contaminants and pediatric health, a continuing subject of public concern. As a consequence of the increasing production of new commercial chemicals, many chemicals have appeared in the scientific and public awareness as potential threats to health. These new or novel compounds eventually distribute in the environment and often are termed emerging contaminants. Gitterman and Bearer stated, "Children may serve as unwitting sentinels for society; they are often the youngest exposed to many environmental toxicants and may become the youngest in age to manifest adverse responses." The discipline of pediatric environmental health is still in its adolescence, but it will be increasingly important as new chemicals are generated and as more is learned about the health effects of chemicals already in commerce. Here, we provide an overview of recent advances in biomonitoring and environmental monitoring of environmental contaminants including emerging contaminants. Our purpose in writing this commentary is to make pediatricians aware of the current resources available for learning about pediatric environmental health and of ongoing research initiatives that provide opportunities to improve pediatric environmental health.

  14. Precision medicine: opportunities, possibilities, and challenges for patients and providers.

    PubMed

    Adams, Samantha A; Petersen, Carolyn

    2016-07-01

    Precision medicine approaches disease treatment and prevention by taking patients' individual variability in genes, environment, and lifestyle into account. Although the ideas underlying precision medicine are not new, opportunities for its more widespread use in practice have been enhanced by the development of large-scale databases, new methods for categorizing and representing patients, and computational tools for analyzing large datasets. New research methods may create uncertainty for both healthcare professionals and patients. In such situations, frameworks that address ethical, legal, and social challenges can be instrumental for facilitating trust between patients and providers, but must protect patients while not stifling progress or overburdening healthcare professionals. In this perspective, we outline several ethical, legal, and social issues related to the Precision Medicine Initiative's proposed changes to current institutions, values, and frameworks. This piece is not an exhaustive overview, but is intended to highlight areas meriting further study and action, so that precision medicine's goal of facilitating systematic learning and research at the point of care does not overshadow healthcare's goal of providing care to patients. PMID:26977101

  15. Mapping Pedagogical Opportunities Provided by Mathematics Analysis Software

    ERIC Educational Resources Information Center

    Pierce, Robyn; Stacey, Kaye

    2010-01-01

    This paper proposes a taxonomy of the pedagogical opportunities that are offered by mathematics analysis software such as computer algebra systems, graphics calculators, dynamic geometry or statistical packages. Mathematics analysis software is software for purposes such as calculating, drawing graphs and making accurate diagrams. However, its…

  16. Providing capital for physician group practices: new opportunities for hospitals.

    PubMed

    Coddington, D C; Moore, K D; Clarke, R L

    1999-12-01

    As physician group practices grow and consolidate, they have an increasing interest in developing close capital partnerships to ensure access to capital. Yet as many healthcare organizations have sought to divest poorly performing acquired physician practices, physicians have seen their pool of potential capital partners shrink. Under these conditions, hospitals have a new opportunity to present themselves to physician group practices as attractive capital partners. To understand the nature of this opportunity, one needs to know why group practices seek capital, how groups approach their investment strategies, and what criteria they use to compare prospective capital partners. To build stronger relationships with physicians, hospitals should focus on turning around their poorly performing acquired physician practices and pursue strategies such as collaborating with physician practice management companies and developing new models for partnering with physicians (e.g., special purchase agreements and more advanced management services organizations). PMID:11066695

  17. Launching Science: Science Opportunities Provided by NASA's Constellation System

    NASA Astrophysics Data System (ADS)

    Committee On Science Opportunities Enabled By NASA's Constellation System National Research Board

    In January 2004 NASA was given a new policy direction known as the Vision for Space Exploration. That plan, now renamed the United States Space Exploration Policy, called for sending human and robotic missions to the Moon, Mars, and beyond. In 2005 NASA outlined how to conduct the first steps in implementing this policy and began the development of a new human-carrying spacecraft known as Orion, the lunar lander known as Altair, and the launch vehicles Ares I and Ares V. Collectively, these are called the Constellation System. In November 2007 NASA asked the National Research Council (NRC) to evaluate the potential for new science opportunities enabled by the Constellation System of rockets and spacecraft. The NRC committee evaluated a total of 17 mission concepts for future space science missions. Of those, the committee determined that 12 would benefit from the Constellation System and five would not. This book presents the committee's findings and recommendations, including cost estimates, a review of the technical feasibility of each mission, and identification of the missions most deserving of future study.

  18. Launching Science: Science Opportunities Provided by NASA's Constellation System

    NASA Technical Reports Server (NTRS)

    2008-01-01

    In 2004 NASA began implementation of the first phases of a new space exploration policy. This implementation effort included the development of a new human-carrying spacecraft, known as Orion; the Altair lunar lander; and two new launch vehicles, the Ares I and Ares V rockets.collectively called the Constellation System (described in Chapter 5 of this report). The Altair lunar lander, which is in the very preliminary concept stage, is not discussed in detail in the report. In 2007 NASA asked the National Research Council (NRC) to evaluate the science opportunities enabled by the Constellation System. To do so, the NRC established the Committee on Science Opportunities Enabled by NASA's Constellation System. In general, the committee interpreted "Constellation-enabled" broadly, to include not only mission concepts that required Constellation, but also those that could be significantly enhanced by Constellation. The committee intends this report to be a general overview of the topic of science missions that might be enabled by Constellation, a sort of textbook introduction to the subject. The mission concepts that are reviewed in this report should serve as general examples of kinds of missions, and the committee s evaluation should not be construed as an endorsement of the specific teams that developed the mission concepts or of their proposals. Additionally, NASA has a well-developed process for establishing scientific priorities by asking the NRC to conduct a "decadal survey" for a particular discipline. Any scientific mission that eventually uses the Constellation System will have to be properly evaluated by means of this decadal survey process. The committee was impressed with the scientific potential of many of the proposals that it evaluated. However, the committee notes that the Constellation System has been justified by NASA and selected in order to enable human exploration beyond low Earth orbit.not to enable science missions. Virtually all of the science

  19. Biosimilars: Opportunities to Promote Optimization Through Payer and Provider Collaboration.

    PubMed

    Manolis, Chronis H; Rajasenan, Kiran; Harwin, William; McClelland, Scott; Lopes, Maria; Farnum, Carolyn

    2016-09-01

    A panel was convened that consisted of 1 medical director, 2 pharmacy directors, and 2 oncologists, who represented the University of Pittsburgh Medical Center Health Plan, an integrated delivery network, and Florida Blue, a progressive regional health plan. This panel met in order to share ideas, discuss challenges, and develop practical solutions to promote optimal utilization in order to encourage collaboration between payers and providers to help ensure the success of biosimilar entrants into the marketplace. Live meetings were conducted in Orlando, Florida, and Pittsburgh, Pennsylvania, and were followed by virtual meetings to solidify ideas and concepts for this supplement. It is important for biosimilar manufacturers to identify potential payer, provider, and patient obstacles in order to develop strategic and tactical plans to preemptively address these potential obstacles. Gathering payer and provider insights will shed light on various issues such as access and reimbursement. Biosimilar manufacturers must be proactive in the education of payers, providers, and patients to ensure access to biosimilars. A strong factor emphasized among this group was that the assumption surrounding biosimilar development and use is the potential for health care cost savings. According to the panel, payers and providers must carefully consider economic implications and potential cost-effectiveness in order to increase the acceptance or understanding of biosimilars in clinical practice. The group identified 3 major challenges surrounding biosimilar adoption: (1) provider confidence in biosimilar education and clinical value, (2) provider confidence in reimbursement for new biosimilars, and (3) creating shared payer and provider cost-savings. After identification of the 3 challenges, the group posed potential solutions to help with biosimilar adoption. PMID:27579939

  20. 75 FR 3939 - Merit Systems Protection Board (MSPB) Provides Notice of Opportunity To File Amicus Briefs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... BOARD Merit Systems Protection Board (MSPB) Provides Notice of Opportunity To File Amicus Briefs AGENCY..., the Merit Systems Protection Board (MSPB) is providing notice of the opportunity to file amicus briefs... eligibility for employment in a sensitive position. Interested parties may submit amicus briefs or...

  1. Active Play Opportunities at Child Care

    PubMed Central

    Saelens, Brian E.; Christakis, Dimitri A.

    2015-01-01

    BACKGROUND AND OBJECTIVES: Physical activity (PA) is important for children’s health and development, yet preschoolers are not meeting PA recommendations. The objective of this study was to examine different PA opportunities at child care and how variation in indoor versus outdoor and free versus teacher-led opportunities relate to children’s PA. METHODS: An observational study of 98 children (mean age 4.5 years, 49% girls) from 10 child care centers. Classrooms were observed for at least 4 full days per center (total 50 days) to categorize time into (1) not an active play opportunity (APO); (2) naptime; (3) APO, outdoor free play; (4) APO, outdoor teacher-led; (5) APO, indoor free play; and (6) APO, indoor teacher-led. Children wore accelerometers during observations. Linear regression models examined the influence of APO categories on moderate-vigorous physical activity (MVPA) and sedentary time. RESULTS: Children’s activity was 73% sedentary, 13% light, and 14% MVPA. For 88% of time children did not have APOs, including 26% time as naptime. On average, 48 minutes per day were APOs (41% sedentary, 18% light, and 41% MVPA), 33 minutes per day were outdoors. The most frequent APO was outdoor free play (8% of time); outdoor teacher-led time was <1%. Children were more active and less sedentary outdoors versus indoors and during the child-initiated APOs (indoors and outdoors) versus teacher-led APOs. CONCLUSIONS: Preschoolers were presented with significantly fewer than recommended opportunities for PA at child care. More APOs are needed for children to meet recommendations, particularly those that encourage more outdoor time, more teacher-led and child-initiated active play, and flexibility in naptime for preschoolers. PMID:25986016

  2. Primary 4T1 tumor resection provides critical "window of opportunity" for immunotherapy.

    PubMed

    Ghochikyan, Anahit; Davtyan, Arpine; Hovakimyan, Armine; Davtyan, Hayk; Poghosyan, Anna; Bagaev, Alexander; Ataullakhanov, Ravshan I; Nelson, Edward L; Agadjanyan, Michael G

    2014-02-01

    It is believed that primary tumor resection modulates host-tumor immune interaction, but this has not been characterized in a stringent breast cancer tumor model. This report, using the 4T1 murine mammary tumor model, characterizes for the first time the dynamic longitudinal changes in immunosuppressive and effector components of the immune system after resection of an established orthotopic primary tumor with a defined natural history of developing lung metastases. More specifically, we analyzed changes of absolute numbers and frequencies of MDSC, regulatory T cells (Treg), as well as activated CD4 and CD8 positive T cells in spleens and, in some studies, lungs of 4T1 tumor-bearing mice and mice after primary tumor resection. Importantly, using mathematical analyses we established that primary resection of an orthotopic tumor had created a "window of opportunity" with decreased tumor-associated immune suppression that existed for approximately 10 days. Although tumor resection did slightly prolong survival, it did not affect the ultimate development of metastatic disease since animals with resected tumors or intact primary tumors eventually died by day 47 and 43, respectively. This window of opportunity likely occurs in humans providing a rationale and parameters for integration and testing of immunotherapeutic strategies in this critical "window of opportunity" to combat the development of metastatic disease. PMID:24096737

  3. Primary 4T1 tumor resection provides critical "window of opportunity" for immunotherapy.

    PubMed

    Ghochikyan, Anahit; Davtyan, Arpine; Hovakimyan, Armine; Davtyan, Hayk; Poghosyan, Anna; Bagaev, Alexander; Ataullakhanov, Ravshan I; Nelson, Edward L; Agadjanyan, Michael G

    2014-02-01

    It is believed that primary tumor resection modulates host-tumor immune interaction, but this has not been characterized in a stringent breast cancer tumor model. This report, using the 4T1 murine mammary tumor model, characterizes for the first time the dynamic longitudinal changes in immunosuppressive and effector components of the immune system after resection of an established orthotopic primary tumor with a defined natural history of developing lung metastases. More specifically, we analyzed changes of absolute numbers and frequencies of MDSC, regulatory T cells (Treg), as well as activated CD4 and CD8 positive T cells in spleens and, in some studies, lungs of 4T1 tumor-bearing mice and mice after primary tumor resection. Importantly, using mathematical analyses we established that primary resection of an orthotopic tumor had created a "window of opportunity" with decreased tumor-associated immune suppression that existed for approximately 10 days. Although tumor resection did slightly prolong survival, it did not affect the ultimate development of metastatic disease since animals with resected tumors or intact primary tumors eventually died by day 47 and 43, respectively. This window of opportunity likely occurs in humans providing a rationale and parameters for integration and testing of immunotherapeutic strategies in this critical "window of opportunity" to combat the development of metastatic disease.

  4. Improving Science and IT Literacy by Providing Urban-Based Environmental Science Research Opportunities

    NASA Astrophysics Data System (ADS)

    Cuff, K. E.; Corazza, L.; Liang, J.

    2007-12-01

    A U.C. Berkeley-based outreach program known as Environmental Science Information Technology Activities has been in operation over the past four years. The primary aim of the program is to provide opportunities for grades 9 and 10 students in diverse East San Francisco Bay Area communities to develop deeper understandings of the nature and conduct of science, which will increase their capacity to enroll and perform successfully in science, technology, engineering, and mathematics (STEM) courses in the future. Design of the program has been informed by recent research that indicates a close relationship between educational activities that promote the perception of STEM as being relevant and the ability to foster development of deeper conceptual understandings among teens. Accordingly, ESITA includes an important student-led environmental science research project component, which provides participants with opportunities to engage in research investigations that are directly linked to relevant, real-world environmental problems and issues facing their communities. Analysis of evidence gleaned from questionnaires, interviews with participants and specific assessment/evaluation instruments indicates that ESITA program activities, including after-school meetings, summer and school year research projects, and conference preparations and presentations has provided students with high-quality inquiry science experiences that increased their knowledge of STEM and IT concepts, as well as their understanding of the nature of the scientific enterprise. In addition, the program has achieved a high degree of success in that it has: enhanced participants' intellectual self-confidence with regard to STEM; developed deeper appreciation of how scientific research can contribute to the maintenance of healthy local environments; developed a greater interest in participating in STEM-related courses of study and after school programs; and improved attitudes toward STEM. Overall

  5. Agricultural Education: Key to Providing Broader Opportunities for Third World Women in Production Agriculture.

    ERIC Educational Resources Information Center

    Lelle, Mark A.; Holt, Barbara A.

    1987-01-01

    The authors focus on providing opportunities for women in Third World countries in agriculture. A review of the body of knowledge in agricultural development and of the issues surrounding current world food crises is included. (CH)

  6. Using Activity Theory to Understand Entrepreneurial Opportunity

    ERIC Educational Resources Information Center

    Holt, Robin

    2008-01-01

    Entrepreneurship is often described as the ability to recognize and exploit opportunities. Identifying opportunities is intentional and idiosyncratic insofar as they are recognized as opportunities is a novel and conscious event (otherwise the entrepreneur would be doing nothing new). Yet opportunities also have to be recognized by others as ones…

  7. Cultural investment: providing opportunities to reduce risky behavior among gay American Indian males.

    PubMed

    Gilley, Brian Joseph; Co-Cké, John Hawk

    2005-09-01

    Many gay American Indian (GAI) men feel alienated from their tribal, ceremonial and social communities because of homophobia and heterosexism. As a result, they often turn to their local gay community for social participation and sex opportunities. It is no secret that a significant aspect of some gay communities is socializing in local bars and clubs. The gay bar scene makes healthy living difficult for Native American gay men. This is especially the case for those who are in alcohol or drug recovery. In response, gay Native men's support groups are attempting to make available a cultural alternative to the double bind of alienation from one's Native community and exposure to substance abuse by providing alcohol and substance free opportunities for ceremonial and social involvement. The hope is that the men will go to bars less frequently and instead turn to Native cultural activities in men's groups for social, spiritual and emotional support. The logic of this approach assumes that individuals who are culturally invested in a community will gain a level of self and social acceptance, making them less likely to abuse substances and put themselves at risk for HIV infection. The information presented in this article comes from over six years of ethnographic research among GAI men concerning self and social acceptance, HIV/AIDS and American Indian GLBT identity. PMID:16295012

  8. Proposed Pilot Program for P.R.O.W.L.--Providing Resource Opportunities with Learning.

    ERIC Educational Resources Information Center

    2000

    As schools guide students in acquiring the skills and knowledge necessary to become responsible citizens, the question arises as to how they can better go about providing them with a well-rounded education: academically, socially, and emotionally. Providing Resource Opportunities with Learning (P.R.O.W.L.) suggests the following solutions: (1)…

  9. Windows to the Future: Can the United Nations Sustainable Development Goals Provide Opportunities for Nursing?

    PubMed

    Benton, David C; Ferguson, Stephanie L

    2016-01-01

    Windows of opportunity are wide open for the nursing profession to actively participate and engage in the policy implementation, evaluation, and achievement of the United Nations Sustainable Development Goals. Nurses bring valuable perspectives as members of diverse governance structures and offer a range of solutions that can help governments pursue and achieve the Sustainable Development Goals and targets by 2030.

  10. On the Pathway to Exciting Careers in Research: NIH Is Providing Opportunities for Biomedical Native Students.

    ERIC Educational Resources Information Center

    Poodry, Clifton

    1994-01-01

    Introduces Minority Opportunities in Research programs of the National Institute of General Medical Sciences: Minority Access to Research Careers Program, Minority Biomedical Research Support Program, National Minority Predoctoral Fellowship Program, and Research Supplements for Underrepresented Minorities Program. These programs provide financial…

  11. Strengthening Family Capacity to Provide Young Children Everyday Natural Learning Opportunities

    ERIC Educational Resources Information Center

    Swanson, Jennifer; Raab, Melinda; Dunst, Carl J.

    2011-01-01

    A capacity-building approach to natural learning environment intervention practices was the focus of the study. Capacity-building early childhood intervention promotes parents' or other caregivers' skills, abilities, and confidence to provide children development-enhancing learning opportunities. Natural environment practices use everyday…

  12. What Educational Opportunities Should Professionals in Aging Provide?: A Pilot Community Assessment

    ERIC Educational Resources Information Center

    Van Dussen, Daniel J.; Leson, Suzanne M.

    2010-01-01

    With the aging workforce and the increase of older adults, educational needs of the workforce in aging services are broadening. The pilot study used a survey to examine the types of educational opportunities and needs of professionals providing services to older adults in eastern Ohio and western Pennsylvania. Respondents (25.9%) reported learning…

  13. Instructional Design Strategies Used to Provide Equal Learning Opportunity for Deaf and Hard of Hearing Learners

    ERIC Educational Resources Information Center

    Mercado Cruz, Daniel

    2013-01-01

    Traditional classrooms are not being designed with deaf and hard of hearing learners in mind. Providing equal learning opportunities with the use of appropriate instructional design strategies to deaf and hard of hearing learners requires that instructional designers, faculty, and educational institutions understand what accommodations and…

  14. Experiments, contingencies, and curriculum: Providing opportunities for learning through improvisation in science teaching

    NASA Astrophysics Data System (ADS)

    Kelly, Gregory J.; Brown, Candice; Crawford, Teresa

    2000-09-01

    In this article, we examine how, through discourse processes, a third grade teacher and her students come to situationally define science in their classroom. The teacher's use of particular discursive strategies promoted student talk, thus providing opportunities for students to learn about science through the exploration of a set of anomalous results in a life science experiment. Drawing from social studies of science, we used a discourse analytical approach to examine the classroom members' logic of experimentation, their explanations and scientific decisions, and their accounts of the events. These analyses allowed us to identify how particular teaching strategies afforded students opportunities to learn science concepts and about scientific processes.

  15. Better Together: Co-Location of Dental and Primary Care Provides Opportunities to Improve Oral Health.

    PubMed

    Pourat, Nadereh; Martinez, Ana E; Crall, James J

    2015-09-01

    Community Health Centers (CHCs) are one of the principal safety-net providers of health care for low-income and uninsured populations. Co-locating dental services in primary care settings provides an opportunity to improve access to dental care. Yet this study of California CHCs that provide primary care services shows that only about one-third of them co-located primary and dental care services on-site. An additional one-third were members of multisite organizations in which at least one other site provided dental care. The remaining one-third of CHC sites had no dental care capacity. Policy options to promote co-location include requiring on-site availability of dental services, providing infrastructure funding to build and equip dental facilities, and offering financial incentives to provide dental care and recruit dental providers.

  16. Providing Opportunities for Deeper Learning. Findings from the Study of Deeper Learning Opportunities and Outcomes: Report 2

    ERIC Educational Resources Information Center

    Bitter, Catherine; Taylor, James; Zeiser, Kristina L.; Rickles, Jordan

    2014-01-01

    The "Study of Deeper Learning: Opportunities and Outcomes"--funded by the William and Flora Hewlett Foundation--aimed to determine whether students attending high schools with a mature and at least moderately well implemented approach to promoting deeper learning actually experienced greater deeper learning opportunities and outcomes…

  17. Improving Attitudes Toward STEM By Providing Urban-Based Environmental Science Research Opportunities

    NASA Astrophysics Data System (ADS)

    Cuff, K. E.; Molinaro, M.

    2005-12-01

    Over the past decade, numerous calls have been made for the need to increase the participation of the nation's underrepresented population in science, technology, engineering, and technology (STEM) fields of endeavor. A key element in improving the less than impressive conditions that now exist with regard to this issue, is the development of effective approaches that result in positive changes in young people's attitudes toward education in general, and STEM subject matter in particular during the early stages of their intellectual development. The Environmental Science Information Technology Activities (ESITA) program provides opportunities for under-represented grades 9 - 10 students in the East San Francisco Bay Area to learn about and apply key STEM concepts and related skills. Consisting of two-year-long after school programs at community center and school-based sites, as well as a Summer Research Institute, the ESITA program engages participants in a combination of STEM content learning activities and environmental science research projects that address issues relevant to their communities. Design of the ESITA program has been informed by: 1) pilot-study data that indicated key elements necessary for ensuring high levels of participant enthusiasm and interest; 2) a conceptual framework for development of instructional materials grounded in recent research about student learning of STEM content; and 3) research about effective after school programs that present academic content. Throughout the program's two-year existence, ESITA students have participated in the following projects: investigations of the distribution of elevated lead levels in drinking water samples from Washington, D.C.; air and water quality studies in and around a popular lake situated within the nation's oldest wildlife refuge, located in downtown Oakland, California; and studies of the relationship between airborne particulate matter concentrations in Richmond, California, and activity at

  18. Opportunities for strengthening provider-initiated testing and counselling for HIV in Namibia.

    PubMed

    Davyduke, Tracy; Pietersen, Ismelda; Lowrance, David; Amwaama, Selma; Taegtmeyer, Miriam

    2015-01-01

    This short report identifies enablers and barriers to the uptake of provider-initiated testing and counselling for HIV (PITC) in Namibia and identifies key opportunities for strengthening this vital aspect of the national HIV response. We explored this through facility mapping, register reviews and qualitative methods including focus group discussions and in-depth interviews. Four health facilities (clinics and hospitals) in two regions were included in the study. We identified that PITC in Namibia was largely delivered by lay counsellors operating in designated rapid testing rooms located in health facilities and found a large number of missed opportunities for HIV testing through this model. Nurses did not see it as an integral part of their role, were not aware of HIV testing and counselling policy, felt inadequately trained and supported, and experienced staffing shortages. Institutional issues also acted as barriers to nurses performing or initiating discussions about PITC. Wider dissemination and implementation of policy, increasing privacy of consultation spaces and community sensitisation are simple measures that represent opportunities for strengthening this response and ensuring that symptomatic individuals who are unaware of their HIV status do not fall through the net.

  19. Providing Children and Adolescents Opportunities for Social Interaction as a Standard of Care in Pediatric Oncology.

    PubMed

    Christiansen, Heather L; Bingen, Kristin; Hoag, Jennifer A; Karst, Jeffrey S; Velázquez-Martin, Blanca; Barakat, Lamia P

    2015-12-01

    Experiences with peers constitute an important aspect of socialization, and children and adolescents with cancer may experience reduced social interaction due to treatment. A literature review was conducted to investigate the evidence to support a standard of care evaluating these experiences. Sixty-four articles were reviewed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Moderate quality of evidence suggest that social interaction can be beneficial to increase knowledge, decrease isolation, and improve adjustment and constitute an important, unmet need. The evidence supports a strong recommendation for youth with cancer to be provided opportunities for social interaction following a careful assessment of their unique characteristics and preferences.

  20. Partial liquidation rules provide stockholder tax saving opportunities in oil and gas divestitures

    SciTech Connect

    Blatz, R.E. Jr.

    1984-09-01

    Oil and gas companies are looking at divestiture as a result of the current oil glut. A summary of the current rules governing partial liquidations focuses on stockholder gain or loss calculations in qualified partial liquidations. These calculations are not routine, and can provide a tax-saving opportunity for the stockholders. Revenue Ruling 81-3 and 77-245 mandate a specific mechanical computation in determining the number of shares considered surrendered, but the stockholder has some latitude in planning his gain or loss by selecting the specific shares to be surrendered. 24 references, 3 tables.

  1. Opportunities and Challenges for Water and Wastewater Industries to Provide Exchangeable Services

    SciTech Connect

    Sparn, Bethany; Hunsberger, Randolph

    2015-11-13

    Water and wastewater treatment plants and distribution systems use significant amounts of energy, around 2 - 4% of the total electricity used in the US, and their energy use is projected to increase as populations increase and regulations become more stringent. Water and wastewater systems have largely been disconnected from the electric utilities' efforts to improve energy efficiency and provide energy efficiency and provide grid services, likely because their core mission is to provide clean water and treated wastewater. Energy efficiency has slowly crept into the water and wastewater industry as the economic benefit has become more apparent, but there is still potential for significant improvement. Some of the larger, more progressive water utilities are starting to consider providing grid services; however, it remains a foreign concept to many. This report explores intrinsic mechanisms by which the water and wastewater industries can provide exchangeable services, the benefit to the parties involved, and the barriers to implementation. It also highlights relevant case studies and next steps. Although opportunities for increasing process efficiencies are certainly available, this report focuses on the exchangeable services that water and wastewater loads can provide to help maintain grid reliability, keep overall costs down, and increase the penetration of distributed renewables on the electric grid. These services have potential to provide water utilities additional value streams, using existing equipment with modest or negligible upgrade cost.

  2. Policies and Opportunities for Physical Activity in Middle School Environments

    PubMed Central

    Young, Deborah R.; Felton, Gwen M.; Grieser, Mira; Elder, John P.; Johnson, Carolyn; Lee, Jung-Sun; Kubik, Martha Y.

    2008-01-01

    BACKGROUND This study examined physical activity opportunities and barriers at 36 geographically diverse middle schools participating in the Trial of Activity for Adolescent Girls. METHODS Principals, physical education and health education department heads, and program leaders were interviewed to assess policies and instructional practices that support physical activity. RESULTS Schools provided approximately 110 hours per year in physical education instruction. Approximately 20% of students walked or bicycled to school. Eighty-three percent of schools offered interscholastic sports and 69% offered intramural sports. Most schools offered programs for girls, but on average, only 24 girls (~5%) in the schools attended any programs. Only 25% of schools allowed after school free play. An overall score created to assess school environmental support for physical activity indicated that, on average, schools met 6.7 items of 10 items. Free/reduced lunch program participation versus not (p = .04), perceived priority of physical education instruction over coaching (p = .02), and safety for walking/bicycling to school (p = .02) predicted environmental support score. CONCLUSIONS Schools have policies and practices that support physical activity, although unfavorable practices exist. Schools must work with community partners and officials to provide environments that optimally support physical activity, especially schools that serve low-income students. PMID:17212759

  3. Positive Youth Development through Physical Activity: Opportunities for Physical Educators

    ERIC Educational Resources Information Center

    Hemphill, Michael A.

    2014-01-01

    As physical educators continue to advocate for school-based PE, they should also consider ways to extend their work into community settings in an effort to ensure that all kids have an opportunity to develop physical literacy. This article describes how positive youth development programs can provide an opportunity for physical educators to engage…

  4. 39 CFR 778.8 - How does the Postal Service provide states an opportunity to comment on proposed facility project...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false How does the Postal Service provide states an opportunity to comment on proposed facility project actions? 778.8 Section 778.8 Postal Service UNITED STATES... How does the Postal Service provide states an opportunity to comment on proposed facility...

  5. 39 CFR 778.8 - How does the Postal Service provide states an opportunity to comment on proposed facility project...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false How does the Postal Service provide states an opportunity to comment on proposed facility project actions? 778.8 Section 778.8 Postal Service UNITED STATES... How does the Postal Service provide states an opportunity to comment on proposed facility...

  6. 39 CFR 778.8 - How does the Postal Service provide states an opportunity to comment on proposed facility project...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false How does the Postal Service provide states an opportunity to comment on proposed facility project actions? 778.8 Section 778.8 Postal Service UNITED STATES... How does the Postal Service provide states an opportunity to comment on proposed facility...

  7. 39 CFR 778.8 - How does the Postal Service provide states an opportunity to comment on proposed facility project...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false How does the Postal Service provide states an opportunity to comment on proposed facility project actions? 778.8 Section 778.8 Postal Service UNITED STATES... How does the Postal Service provide states an opportunity to comment on proposed facility...

  8. Maine 4-H Afterschool Academy--A Professional Development Opportunity for Out-of-School-Time Providers

    ERIC Educational Resources Information Center

    Lobley, Jennifer; Ouellette, Kristy L.

    2013-01-01

    The Maine 4-H Afterschool Academy trained 369 after-school and out of school time providers in 2011. This easy-to-adapt professional development opportunity used blended learning, a combination of in-person and Web-based opportunities. Providers successfully learned concepts and practical knowledge regarding 4-H, specifically 4-H Science. In…

  9. 34 CFR 647.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... provide the following services and activities: (1) Opportunities for research or other scholarly... effective preparation for doctoral study. (2) Summer internships. (3) Seminars and other educational... planning for postsecondary education. (2) Mentoring programs involving faculty members at institutions...

  10. 34 CFR 647.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provide the following services and activities: (1) Opportunities for research or other scholarly... effective preparation for doctoral study. (2) Summer internships. (3) Seminars and other educational... planning for postsecondary education. (2) Mentoring programs involving faculty members at institutions...

  11. 34 CFR 647.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... provide the following services and activities: (1) Opportunities for research or other scholarly... effective preparation for doctoral study. (2) Summer internships. (3) Seminars and other educational... planning for postsecondary education. (2) Mentoring programs involving faculty members at institutions...

  12. 34 CFR 647.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... provide the following services and activities: (1) Opportunities for research or other scholarly... effective preparation for doctoral study. (2) Summer internships. (3) Seminars and other educational... planning for postsecondary education. (2) Mentoring programs involving faculty members at institutions...

  13. Providing Rich Art Activities for Young Children

    ERIC Educational Resources Information Center

    Mulcahey, Christine

    2009-01-01

    Using works of art with young children is a perfect way to bridge the gap between art activities that are too open or too closed. Teachers of young children sometimes try to find a middle ground by allowing free painting time at an easel in addition to recipe-oriented activities such as putting together precut shapes to create a spider or an apple…

  14. Health Care Provider Physical Activity Prescription Intervention

    ERIC Educational Resources Information Center

    Josyula, Lakshmi; Lyle, Roseann

    2013-01-01

    Purpose: To examine the feasibility and impact of a health care provider’s (HCP) physical activity (PA) prescription on the PA of patients on preventive care visits. Methods: Consenting adult patients completed health and PA questionnaires and were sequentially assigned to intervention groups. HCPs prescribed PA using a written prescription only…

  15. ELaNa - Educational Launch of Nanosatellite Providing Routine RideShare Opportunities

    NASA Technical Reports Server (NTRS)

    Skrobot, Garrett Lee; Coelho, Roland

    2012-01-01

    Since the creation of the NASA CubeSat Launch Initiative (NCSLI), the need for CubeSat rideshares has dramatically increased. After only three releases of the initiative, a total of 66 CubeSats now await launch opportunities. So, how is this challenge being resolved? NASA's Launch Services Program (LSP) has studied how to integrate PPODs on Athena, Atlas V, and Delta IV launch vehicles and has been instrumental in developing several carrier systems to support CubeSats as rideshares on NASA missions. In support of the first two ELaNa missions the Poly-Picosatellite Orbital Deployer (P-POD) was adapted for use on a Taurus XL (ELaNa I) and a Delta n (ELaNa III). Four P-PODs, which contained a total eight CubeSats, were used on these first ELaNa missions. Next up is ELaNa VI, which will launch on an Atlas V in August 2012. The four ELaNa VI CubeSats, in three P-PODs, are awaiting launch, having been integrated in the NPSCuLite. To increase rideshare capabilities, the Launch Services Program (LSP) is working to integrate P-PODs on Falcon 9 missions. The proposed Falcon 9 manifest will provide greater opportunities for the CubeSat community. For years, the standard CubeSat size was 1 U to 3U. As the desire to include more science in each cube grows, so does the standard CubeSat size. No longer is a 1 U, 1.5U, 2U or 3U CubeSat the only option available; the new CubeSat standard will include 6U and possibly even 12U. With each increase in CubeSat size, the CubeSat community is pushing the capability of the current P-POD design. Not only is the carrier system affected, but integration to the Launch Vehicle is also a concern. The development of a system to accommodate not only the 3U P-POD but also carriers for larger CubeSats is ongoing. LSP considers payloads in the lkg to 180 kg range rideshare or small/secondary payloads. As new and emerging small payloads are developed, rideshare opportunities and carrier systems need to be identified and secured. The development of a

  16. Opportunity-to-Learn Context-Based Tasks Provided by Mathematics Textbooks

    ERIC Educational Resources Information Center

    Wijaya, Ariyadi; van den Heuvel-Panhuizen, Marja; Doorman, Michiel

    2015-01-01

    Based on the findings of an error analysis revealing that Indonesian ninth- and tenth-graders had difficulties in solving context-based tasks, we investigated the opportunity-to-learn offered by Indonesian textbooks for solving context-based mathematics tasks and the relation of this opportunity-to-learn to students' difficulties in solving these…

  17. Factors Shaping Students' Opportunities to Engage in Argumentative Activity

    ERIC Educational Resources Information Center

    Ayalon, Michal; Even, Ruhama

    2016-01-01

    This study examines how students' opportunities to engage in argumentative activity are shaped by the teacher, the class, and the mathematical topic. It compares the argumentative activity between two classes taught by the same teacher using the same textbook and across two beginning algebra topics--investigating algebraic expressions and…

  18. Physical Activity Opportunity in United States Public Elementary Schools

    ERIC Educational Resources Information Center

    Beaulieu, Lisa; Butterfield, Stephen A.; Pratt, Phillip

    2009-01-01

    Recent evidence indicates that many elementary schools have curtailed recess and Physical Education (Morrow, Jackson & Payne 1999). These finding are at a variance with the goal of Healthy People 2010 to increase physical activity. The purpose of this study was to examine physical activity opportunities (PAO) in U. S. public elementary schools.…

  19. Win/win: creating collaborative training opportunities for behavioral health providers within family medicine residency programs.

    PubMed

    Ruddy, Nancy Breen; Borresen, Dorothy; Myerholtz, Linda

    2013-01-01

    Integrating behavioral health into primary healthcare offers multiple advantages for patients and health professionals. This model requires a new skill set for all healthcare professionals that is not emphasized in current educational models. The new skills include interprofessional team-based care competencies and expanded patient care competencies. Health professionals must learn new ways to efficiently and effectively address health behavior change, and manage behavioral health issues such as depression and anxiety. Learning environments that co-train mental health and primary care professionals facilitate acquisition of both teamwork and patient care competencies for mental health and primary care professional trainees. Family Medicine Residency programs provide an excellent opportunity for co-training. This article serves as a "how to" guide for residency programs interested in developing a co-training program. Necessary steps to establish and maintain a program are reviewed, as well as goals and objectives for a co-training curriculum and strategies to overcome barriers and challenges in co-training models.

  20. Win/win: creating collaborative training opportunities for behavioral health providers within family medicine residency programs.

    PubMed

    Ruddy, Nancy Breen; Borresen, Dorothy; Myerholtz, Linda

    2013-01-01

    Integrating behavioral health into primary healthcare offers multiple advantages for patients and health professionals. This model requires a new skill set for all healthcare professionals that is not emphasized in current educational models. The new skills include interprofessional team-based care competencies and expanded patient care competencies. Health professionals must learn new ways to efficiently and effectively address health behavior change, and manage behavioral health issues such as depression and anxiety. Learning environments that co-train mental health and primary care professionals facilitate acquisition of both teamwork and patient care competencies for mental health and primary care professional trainees. Family Medicine Residency programs provide an excellent opportunity for co-training. This article serves as a "how to" guide for residency programs interested in developing a co-training program. Necessary steps to establish and maintain a program are reviewed, as well as goals and objectives for a co-training curriculum and strategies to overcome barriers and challenges in co-training models. PMID:24261270

  1. Healthcare providers balancing norms and practice: challenges and opportunities in providing contraceptive counselling to young people in Uganda – a qualitative study

    PubMed Central

    Paul, Mandira; Näsström, Sara B.; Klingberg-Allvin, Marie; Kiggundu, Charles; Larsson, Elin C.

    2016-01-01

    Background Pregnancies among young women force girls to compromise education, resulting in low educational attainment with subsequent poverty and vulnerability. A pronounced focus is needed on contraceptive use, pregnancy, and unsafe abortion among young women. Objective This study aims to explore healthcare providers’ (HCPs) perceptions and practices regarding contraceptive counselling to young people. Design We conducted 27 in-depth interviews with doctors and midwives working in seven health facilities in central Uganda. Interviews were open-ended and allowed the participant to speak freely on certain topics. We used a topic guide to cover areas topics of interest focusing on post-abortion care (PAC) but also covering contraceptive counselling. Transcripts were transcribed verbatim and data were analysed using thematic analysis. Results The main theme, HCPs' ambivalence to providing contraceptive counselling to sexually active young people is based on two sub-themes describing the challenges of contraceptive counselling: A) HCPs echo the societal norms regarding sexual practice among young people, while at the same time our findings B) highlights the opportunities resulting from providers pragmatic approach to contraceptive counselling to young women. Providers expressed a self-identified lack of skill, limited resources, and inadequate support from the health system to successfully provide appropriate services to young people. They felt frustrated with the consultations, especially when meeting young women seeking PAC. Conclusions Despite existing policies for young people's sexual and reproductive health in Uganda, HCPs are not sufficiently equipped to provide adequate contraceptive counselling to young people. Instead, HCPs are left in between the negative influence of social norms and their pragmatic approach to address the needs of young people, especially those seeking PAC. We argue that a clear policy supported by a clear strategy with practical

  2. International Observe the Moon Night: Providing Opportunities for the Public to Engage in Lunar Observation

    NASA Astrophysics Data System (ADS)

    Hsu, B. C.; Bleacher, L.; Day, B. H.; Daou, D.; Jones, A. P.; Mitchell, B.; Shaner, A. J.; Shipp, S. S.

    2010-12-01

    International Observe the Moon Night (InOMN) is designed to engage lunar science and education communities, our partner networks, amateur astronomers, space enthusiasts, and the general public in annual lunar observation campaigns that share the excitement of lunar science and exploration. InOMN enables the public to maintain its curiosity about the Moon and gain a better understanding of the Moon's formation, its evolution, and its place in the sky. For 2010, members of the public were encouraged to host their own InOMN events. InOMN hosts such as astronomy clubs, museums, schools, or other groups could find helpful resources and share information about InOMN events they organized on the InOMN website (http://observethemoonnight.org). Images, feedback, and lessons learned from the 2010 InOMN event will be shared in order to encourage increased planning and hosting of InOMN events in 2011. From various interpretations of the lunar “face,” early pictograms of the Moon’s phases, or to the use of the lunar cycle for festivals or harvests, the Moon has an undeniable influence on human civilization. We have chosen the 2011 InOMN theme to provide an opportunity for individuals to share their personal or cultural connections to the Moon. For 2011, the InOMN website will include a ‘lunar bulletin board’ where InOMN participants can post pictures and share stories of what the Moon means to them. The 2011 InOMN contest will encourage people to submit their works of art, poems, short stories, or music about the Moon all centered around the theme “What does the Moon mean to you?” As with the winners of previous contests, winning entries will be incorporated into the following year’s InOMN advertisements and events.

  3. Municipal Government Efforts to Provide Career Employment Opportunities for the Disadvantaged.

    ERIC Educational Resources Information Center

    Decker, Floyd A.; And Others

    The study, conducted in Dayton, Detroit, El Paso, New York City, San Francisco, and Washington, D.C., investigated efforts to create municipal career employment and training opportunities for those who cannot meet traditional entrance requirements. It also examined the impact of programs on municipal services, and ways in which such programs can…

  4. Providing Opportunities for Deeper Learning: Findings from the Study of Deeper Learning

    ERIC Educational Resources Information Center

    Bitter, Catherine; O'Day, Jennifer

    2014-01-01

    The "Study of Deeper Learning: Opportunities and Outcomes," funded by the William and Flora Hewlett Foundation, is a "proof-of-concept" study to determine whether students attending high schools with a mature and at least moderately well-implemented approach to promoting "deeper learning" experience greater deeper…

  5. The Flipped Classroom: An Opportunity to Engage Millennial Students through Active Learning Strategies

    ERIC Educational Resources Information Center

    Roehl, Amy; Reddy, Shweta Linga; Shannon, Gayla Jett

    2013-01-01

    "Flipping" the classroom employs easy-to-use, readily accessible technology in order to free class time from lecture. This allows for an expanded range of learning activities during class time. Using class time for active learning versus lecture provides opportunities for greater teacher-to-student mentoring, peer-to-peer collaboration…

  6. Laboratory Technical Services provides business opportunities for Supervisory Control and Data Acquisition Systems

    SciTech Connect

    Ballard, W.

    1993-05-01

    At this time, I would like to present some additional information about what I consider are some really great opportunities for the business community to participate with us in developing the greatest scientific project in the history of mankind. Facility Engineering Services is part of Laboratory Technical Services. As part of this group, we have the responsibility to direct the construction of interim facilities, scientific labs, production process, cooling towers, cooling ponds and the operation and control of SSC Laboratory conventional support systems. These operations and controls will be accomplished through the employment of a Supervisory Control and Data Acquisition system (SCADA).

  7. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How will Reclamation provide notice of opportunities for assistance under the program? 404.14 Section 404.14 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER...

  8. 75 FR 33362 - Notice of Opportunity To Request a Hearing and Provide Written Comments on Order Approving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... general requirements in Subpart C of 10 CFR Part 2, as amended on January 14, 2004 (69 FR 2182), any... NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing process requires participants to submit... COMMISSION Notice of Opportunity To Request a Hearing and Provide Written Comments on Order...

  9. 24 CFR 52.8 - How does the Secretary provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false How does the Secretary provide states an opportunity to comment on proposed Federal financial assistance and direct Federal development? 52.8 Section 52.8 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development INTERGOVERNMENTAL REVIEW...

  10. 75 FR 20007 - The Merit Systems Protection Board (MSPB) Is Providing Notice of the Opportunity To File Amicus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... From the Federal Register Online via the Government Publishing Office MERIT SYSTEMS PROTECTION BOARD The Merit Systems Protection Board (MSPB) Is Providing Notice of the Opportunity To File Amicus... consider the appeal under 5 U.S.C. Chapter 75, given that the scope of a Chapter 75 appeal is broader...

  11. Mars Public Mapping Project: Public Participation in Science Research; Providing Opportunities for Kids of All Ages

    NASA Astrophysics Data System (ADS)

    Rogers, L. D.; Valderrama Graff, P.; Bandfield, J. L.; Christensen, P. R.; Klug, S. L.; Deva, B.; Capages, C.

    2007-12-01

    The Mars Public Mapping Project is a web-based education and public outreach tool developed by the Mars Space Flight Facility at Arizona State University. This tool allows the general public to identify and map geologic features on Mars, utilizing Thermal Emission Imaging System (THEMIS) visible images, allowing public participation in authentic scientific research. In addition, participants are able to rate each image (based on a 1 to 5 star scale) to help build a catalog of some of the more appealing and interesting martian surface features. Once participants have identified observable features in an image, they are able to view a map of the global distribution of the many geologic features they just identified. This automatic feedback, through a global distribution map, allows participants to see how their answers compare to the answers of other participants. Participants check boxes "yes, no, or not sure" for each feature that is listed on the Mars Public Mapping Project web page, including surface geologic features such as gullies, sand dunes, dust devil tracks, wind streaks, lava flows, several types of craters, and layers. Each type of feature has a quick and easily accessible description and example image. When a participant moves their mouse over each example thumbnail image, a window pops up with a picture and a description of the feature. This provides a form of "on the job training" for the participants that can vary with their background level. For users who are more comfortable with Mars geology, there is also an advanced feature identification section accessible by a drop down menu. This includes additional features that may be identified, such as streamlined islands, valley networks, chaotic terrain, yardangs, and dark slope streaks. The Mars Public Mapping Project achieves several goals: 1) It engages the public in a manner that encourages active participation in scientific research and learning about geologic features and processes. 2) It helps to

  12. Providing a setup and opportunities for better training of postdoctoral research fellows in an academic environment.

    PubMed

    Ghayur, Muhammad N

    2008-01-01

    Thousands of young researchers come from different parts of the world every year to take up postdoctoral (postdoc) research fellowship positions in the developed countries. In the US alone, there were 48,601 postdocs in the year 2005 working in different labs in the fields of science, health and engineering. Many pursue this option for lack of other alternatives. Expectedly, these individuals face a lot of difficulties in making this transition from being a student to becoming an employee of an institution. Many institutions are prepared to make this transition and period of stay easy for their fellows while others are not equipped at all. The presence of a postdoc office (established by an institution) or an association (formed by the fellows) can be of immense help to postdocs. Additionally, the availability of institutional professional development and leadership programs can also help to nurture and polish postdoc fellows into future faculty members and valuable members of the community at large. To name a few, these professional development programs can focus on communication and presentation skills, medical education, teaching and learning, bioethics and mentorship. There is an urgent need to address some or all of these issues so that better training environment and opportunities are available to this group of postdoc fellows.

  13. Medicare+Choice plans. Medicare risk contracting opportunities for provider-sponsored organizations.

    PubMed

    Miller, D S

    1997-01-01

    New federal legislation approves provider sponsored networks as direct contractors with Medicare. To date, financial, licensure and requirements differ, but providers should prepare to enter the new market. Niche physician groups, physician-hospital organizations and physician-HMO alliances are all configurations that should meet federal requirements. PMID:10174974

  14. Opportunities to reduce cancer barriers: Community town halls and provider focus groups

    PubMed Central

    Rafie, Carlin; Cadet, Debbie L.; Ayers, Antoinette

    2012-01-01

    This paper presents the findings from town hall meetings held with community residents and focus groups with healthcare providers. A total of five town halls (N=139) were conducted. Four were conducted in English and a fifth was conducted in Spanish to obtain the input of the local Hispanic community. Surveys were provided to town hall participants to assess their perceptions of cancer and screening as well as their cancer screening behaviors. Participants were asked questions designed to determine local gaps and needs in health and cancer care, and their attitudes regarding breast cancer resources, education, treatment and clinical trials. Additionally, four focus groups (N=45) were held with a wide range of providers to obtain their perspectives on barriers to breast cancer screening, local cancer prevention and care, and clinical trials. Results indicate gaps in local resources and support services, particularly in terms of education and integrated care. PMID:23055135

  15. Tax-exempt private placements: a new opportunity for not-for-profit providers.

    PubMed

    Ambrose, Jim; Harris, Andrew

    2006-08-01

    Tax-exempt private placements offer an attractive financing alternative for not-for-profit healthcare providers for which the public debt market is no longer a viable option. They offer the following advantages: Greater flexibility Lower fees. Less paperwork. Fewer players. Shorter time to complete.

  16. 21st Century Community Learning Centers: Providing Quality Afterschool Learning Opportunities for America's Families.

    ERIC Educational Resources Information Center

    de Kanter, Adriana; Williams, Rebecca; Cohen, Gillian; Stonehill, Robert

    The 21st Century Community Learning Centers program, implemented through a public-private partnership between the U.S. Department of Education and the Charles Stewart Mott Foundation, provides grants to communities to fund public schools as community education centers. The community education centers are intended to allow students after-school…

  17. Science in Sync: Integrating Science with Literacy Provides Rewarding Learning Opportunities in Both Subjects

    ERIC Educational Resources Information Center

    Wallace, Carolyn S.; Coffey, Debra

    2016-01-01

    The "Next Generation Science Standards'" ("NGSS") eight scientific and engineering practices invite teachers to develop key investigative skills while addressing important disciplinary science ideas (NGSS Lead States 2013). The "NGSS" can also provide direct links to "Common Core English Language Arts…

  18. Providing Authentic Leadership Opportunities through Collaboratively Developed Internships: A University-School District Partnership Initiative

    ERIC Educational Resources Information Center

    Havard, Timothy S.; Morgan, Joyce; Patrick, Lynne

    2010-01-01

    Programs designed to develop future educational leaders must include practical learning experiences that connect the theoretical content of university coursework with the realities of the K-12 workplace. Internships, which offer a common method of providing these experiences, have been generally lacking in the degree to which aspiring leaders…

  19. Multiple Ways of Knowing: Fostering Resiliency through Providing Opportunities for Participating in Learning

    ERIC Educational Resources Information Center

    Shepard, Jerri Simms

    2004-01-01

    The model of multiple intelligences developed by Howard Gardner is proposed as a framework for developing strengths, which will provide protective factors against risk and contribute to resilient outcomes. Educators are continually challenged to find successful ways to meet the needs of their students. One means is to support students by…

  20. Providing Early Childhood Teachers with Opportunities to Understand Diversity and the Achievement Gap

    ERIC Educational Resources Information Center

    Meece, Darrell; Wingate, Kimberly O'Kelley

    2010-01-01

    High quality teaching--providing children with support, feedback, and positive communication--is associated with closing the achievement gap between minority and majority children. It is important for students in teacher preparation programs to understand changes in curricular approaches to diversity--from the color-blind approach, to…

  1. Getting Australia more active: challenges and opportunities for health promotion.

    PubMed

    Hills, A P; Street, S J; Harris, N

    2014-04-01

    A growing body of evidence demonstrates that regular physical activity promotes health and assists in the prevention of non-communicable diseases but this is presently curtailed by low and unhealthy participation rates in Australia and comparable industrialised countries. Compounding the problem is knowledge that physical inactivity is independently associated with poor health outcomes. Despite physical activity being described as public health's 'best bet' or 'best buy', motivating individuals and groups to adopt and maintain physical activity continues to be a major challenge for health professionals. Global advocacy for prevention efforts must be operationalised through national to local strategies to promote and support physical activity in multiple settings including the home, schools and workplace. The Australian health promotion community has and continues to play a leadership role in physical activity promotion. However, there is an urgent need to continue to promote the importance of physical activity, along with its pivotal role in the prevention of non-communicable diseases, alongside related agendas including healthy diets, tobacco control and environmental sustainability. This commentary overviews the contemporary status of physical activity promotion in Australia and identifies key challenges and opportunities moving forward.

  2. Provider experiences with RAC appeals point to opportunities for program improvement.

    PubMed

    Jacobs, Robert; Scott, Bonnie; Flood, Elizabeth; Scott, Ellen

    2011-03-01

    Review by an administrative law judge (ALJ) constitutes the third level of appeal for healthcare providers seeking to overturn reverse recovery audit contractor (RAC) findings of overpayment of Medicare claims. An analysis of the results of RAC appeals submitted by 30 New York hospitals during the demonstration project has disclosed two deficiencies in the ALJ review process: inconsistent ALJ decision making and a lack of an appropriate feedback mechanism to correct erroneous overpayment determinations. The Centers for Medicare & Medicaid Services should take advantage of feedback from such studies as an impetus to reevaluate and streamline the RAC appeals process. PMID:21449307

  3. Transgenic male mating advantage provides opportunity for Trojan gene effect in a fish

    PubMed Central

    Howard, Richard D.; DeWoody, J. Andrew; Muir, William M.

    2004-01-01

    Genetically modified (GM) strains now exist for many organisms, producing significant promise for agricultural production. However, if these organisms have some fitness advantage, they may also pose an environmental harm when released. High mating success of GM males relative to WT males provides such an important fitness advantage. Here, we provide documentation that GM male medaka fish modified with salmon growth hormone possess an overwhelming mating advantage. GM medaka offspring possess a survival disadvantage relative to WT, however. When both of these fitness components are included in our model, the transgene is predicted to spread if GM individuals enter wild populations (because of the mating advantage) and ultimately lead to population extinction (because of the viability disadvantage). Mating trials indicate that WT males use alternative mating tactics in an effort to counter the mating advantage of GM males, and we use genetic markers to ascertain the success of these alternative strategies. Finally, we model the impact of alternative mating tactics by WT males on transgene spread. Such tactics may reduce the rate of transgene spread, but not the outcome. PMID:14976259

  4. Technology transfer opportunities: new development: computerized field manual provides valuable resource for hydrologic investigations

    USGS Publications Warehouse

    Chapel, Paul

    1996-01-01

    The U.S. Geological Survey (USGS) is known throughout the world for conducting quality scientific investigation is hydrologic environments. Proper and consistent field techniques have been an integral part of this good research. Over the past few decades, the USGS has developed and published detailed, standard protocols for conducting studies in most aspects of the hydrologic environment. These protocols have been published in a number of diverse documents. The wealth of information contained in these diverse documents can benefit other scientists in industry, government, and academia that are involved in conducting hydrologic studies. Scientists at the USGS have brought together many of the most important of the field protocols in a user-friendly, graphical-interfaced field manual that will be useful in both the field and in the office. This electronic field manual can assist hydrologists and other scientists in conducting and documenting their field activities in a manner that is recognized standard throughout the hydrologic community.

  5. Wood density provides new opportunities for reconstructing past temperature variability from southeastern Australian trees

    NASA Astrophysics Data System (ADS)

    O'Donnell, Alison J.; Allen, Kathryn J.; Evans, Robert M.; Cook, Edward R.; Trouet, Valerie; Baker, Patrick J.

    2016-06-01

    Tree-ring based climate reconstructions have been critical for understanding past variability and recent trends in climate worldwide, but they are scarce in Australia. This is particularly the case for temperature: only one tree-ring width based temperature reconstruction - based on Huon Pine trees from Mt Read, Tasmania - exists for Australia. Here, we investigate whether additional tree-ring parameters derived from Athrotaxis cupressoides trees growing in the same region have potential to provide robust proxy records of past temperature variability. We measured wood properties, including tree-ring width (TRW), mean density, mean cell wall thickness (CWT), and tracheid radial diameter (TRD) of annual growth rings in Athrotaxis cupressoides, a long-lived, high-elevation conifer in central Tasmania, Australia. Mean density and CWT were strongly and negatively correlated with summer temperatures. In contrast, the summer temperature signal in TRW was weakly positive. The strongest climate signal in any of the tree-ring parameters was maximum temperature in January (mid-summer; JanTmax) and we chose this as the target climate variable for reconstruction. The model that explained most of the variance in JanTmax was based on TRW and mean density as predictors. TRW and mean density provided complementary proxies with mean density showing greater high-frequency (inter-annual to multi-year) variability and TRW showing more low-frequency (decadal to centennial-scale) variability. The final reconstruction model is robust, explaining 55% of the variance in JanTmax, and was used to reconstruct JanTmax for the last five centuries (1530-2010 C.E.). The reconstruction suggests that the most recent 60 years have been warmer than average in the context of the last ca. 500 years. This unusually warm period is likely linked to a coincident increase in the intensity of the subtropical ridge and dominance of the positive phase of the Southern Annular Mode in summer, which weaken the

  6. Vitamin Variation in Capsicum Spp. Provides Opportunities to Improve Nutritional Value of Human Diets

    PubMed Central

    Lucht, Sarah A.; Mercer, Kristin; Bernau, Vivian; Case, Kyle A.; Le, Nina C.; Frederiksen, Matthew K.; DeKeyser, Haley C.; Wong, Zen-Zi; Hastings, Jennifer C.

    2016-01-01

    Chile peppers, native to the Americas, have spread around the world and have been integrated into the diets of many cultures. Much like their heat content, nutritional content can vary dramatically between different pepper types. In this study, a diverse set of chile pepper types were examined for nutrient content. Some pepper types were found to have high levels of vitamin A, vitamin C, or folate. Correlations between nutrient content, species, cultivation status, or geographic region were limited. Varietal selection or plant breeding offer tools to augment nutrient content in peppers. Integration of nutrient rich pepper types into diets that already include peppers could help combat nutrient deficiencies by providing a significant portion of recommended daily nutrients. PMID:27532495

  7. Vitamin Variation in Capsicum Spp. Provides Opportunities to Improve Nutritional Value of Human Diets.

    PubMed

    Kantar, Michael B; Anderson, Justin E; Lucht, Sarah A; Mercer, Kristin; Bernau, Vivian; Case, Kyle A; Le, Nina C; Frederiksen, Matthew K; DeKeyser, Haley C; Wong, Zen-Zi; Hastings, Jennifer C; Baumler, David J

    2016-01-01

    Chile peppers, native to the Americas, have spread around the world and have been integrated into the diets of many cultures. Much like their heat content, nutritional content can vary dramatically between different pepper types. In this study, a diverse set of chile pepper types were examined for nutrient content. Some pepper types were found to have high levels of vitamin A, vitamin C, or folate. Correlations between nutrient content, species, cultivation status, or geographic region were limited. Varietal selection or plant breeding offer tools to augment nutrient content in peppers. Integration of nutrient rich pepper types into diets that already include peppers could help combat nutrient deficiencies by providing a significant portion of recommended daily nutrients. PMID:27532495

  8. Healthcare Hackathons Provide Educational and Innovation Opportunities: A Case Study and Best Practice Recommendations.

    PubMed

    Silver, Julie K; Binder, David S; Zubcevik, Nevena; Zafonte, Ross D

    2016-07-01

    Physicians and other healthcare professionals are often the end users of medical innovation; however, they are rarely involved in the beginning design stages. This often results in ineffective healthcare solutions with poor adoption rates. At the early design stage, innovation would benefit from input from healthcare professionals. This report describes the first-ever rehabilitation hackathon-an interdisciplinary and competitive team event aimed at accelerating and improving healthcare solutions and providing an educational experience for participants. Hackathons are gaining traction as a way to accelerate innovation by bringing together a diverse group of interdisciplinary professionals from different industries who work collaboratively in teams and learn from each other, focus on a specific problem ("pain point"), develop a solution using design thinking techniques, pitch the solution to participants, gather fast feedback and quickly alter the prototype design ("pivoting"). 102 hackers including 19 (18.6 %) physicians and other professionals participated, and over the course of 2 days worked in teams, pitched ideas and developed design prototypes. Three awards were given for prototypes that may improve function in persons with disabilities. 43 hackers were women (42.2 %) and 59 men (57.8 %); they ranged in age from 16 to 79 years old; and, of the 75 hackers who reported their age, 63 (84 %) were less than 40 years old and 12 (16 %) were 40 years or older. This report contributes to the emerging literature on healthcare hackathons as a means of providing interdisciplinary education and training and supporting innovation.

  9. Healthcare Hackathons Provide Educational and Innovation Opportunities: A Case Study and Best Practice Recommendations.

    PubMed

    Silver, Julie K; Binder, David S; Zubcevik, Nevena; Zafonte, Ross D

    2016-07-01

    Physicians and other healthcare professionals are often the end users of medical innovation; however, they are rarely involved in the beginning design stages. This often results in ineffective healthcare solutions with poor adoption rates. At the early design stage, innovation would benefit from input from healthcare professionals. This report describes the first-ever rehabilitation hackathon-an interdisciplinary and competitive team event aimed at accelerating and improving healthcare solutions and providing an educational experience for participants. Hackathons are gaining traction as a way to accelerate innovation by bringing together a diverse group of interdisciplinary professionals from different industries who work collaboratively in teams and learn from each other, focus on a specific problem ("pain point"), develop a solution using design thinking techniques, pitch the solution to participants, gather fast feedback and quickly alter the prototype design ("pivoting"). 102 hackers including 19 (18.6 %) physicians and other professionals participated, and over the course of 2 days worked in teams, pitched ideas and developed design prototypes. Three awards were given for prototypes that may improve function in persons with disabilities. 43 hackers were women (42.2 %) and 59 men (57.8 %); they ranged in age from 16 to 79 years old; and, of the 75 hackers who reported their age, 63 (84 %) were less than 40 years old and 12 (16 %) were 40 years or older. This report contributes to the emerging literature on healthcare hackathons as a means of providing interdisciplinary education and training and supporting innovation. PMID:27277278

  10. Antibodies Against Conserved Antigens Provide Opportunities for Reform in Influenza Vaccine Design

    PubMed Central

    Kaminski, Denise A.; Lee, F. Eun-Hyung

    2011-01-01

    High-performance neutralizing antibody against influenza virus typically recognizes the globular head region of its hemagglutinin (HA) envelope glycoprotein. To-date, approved human vaccination strategies have been designed to induce such antibodies as a sole means of preventing the consequences of this infection. However, frequent amino-acid changes in the HA globular head allow for efficient immune evasion. Consequently, vaccines inducing such neutralizing antibodies need to be annually re-designed and re-administered at a great expense. These vaccines furthermore provide little-to-no immunity against antigenic-shift strains, which arise from complete replacement of HA or of neuraminidase genes, and pose pandemic risks. To address these issues, laboratory research has focused on inducing immunity effective against all strains, regardless of changes in the HA globular head. Despite prior dogma that such cross-protection needs to be induced by cellular immunity alone, several advances in recent years demonstrate that antibodies of other specificities are capable of cross-strain protection in mice. This review discusses the reactivity, induction, efficacy, and mechanisms of antibodies that react with poorly accessible epitopes in the HA stalk, with the matrix 2 membrane ion channel, and even with the internal nucleoprotein. These advances warrant further investigation of the inducibility and efficacy of such revolutionary antibody strategies in humans. PMID:22566865

  11. Opportunities and challenges provided by cloud repositories for bioinformatics-enabled drug discovery.

    PubMed

    Dalpé, Gratien; Joly, Yann

    2014-09-01

    Healthcare-related bioinformatics databases are increasingly offering the possibility to maintain, organize, and distribute DNA sequencing data. Different national and international institutions are currently hosting such databases that offer researchers website platforms where they can obtain sequencing data on which they can perform different types of analysis. Until recently, this process remained mostly one-dimensional, with most analysis concentrated on a limited amount of data. However, newer genome sequencing technology is producing a huge amount of data that current computer facilities are unable to handle. An alternative approach has been to start adopting cloud computing services for combining the information embedded in genomic and model system biology data, patient healthcare records, and clinical trials' data. In this new technological paradigm, researchers use virtual space and computing power from existing commercial or not-for-profit cloud service providers to access, store, and analyze data via different application programming interfaces. Cloud services are an alternative to the need of larger data storage; however, they raise different ethical, legal, and social issues. The purpose of this Commentary is to summarize how cloud computing can contribute to bioinformatics-based drug discovery and to highlight some of the outstanding legal, ethical, and social issues that are inherent in the use of cloud services.

  12. Opportunities and challenges provided by cloud repositories for bioinformatics-enabled drug discovery.

    PubMed

    Dalpé, Gratien; Joly, Yann

    2014-09-01

    Healthcare-related bioinformatics databases are increasingly offering the possibility to maintain, organize, and distribute DNA sequencing data. Different national and international institutions are currently hosting such databases that offer researchers website platforms where they can obtain sequencing data on which they can perform different types of analysis. Until recently, this process remained mostly one-dimensional, with most analysis concentrated on a limited amount of data. However, newer genome sequencing technology is producing a huge amount of data that current computer facilities are unable to handle. An alternative approach has been to start adopting cloud computing services for combining the information embedded in genomic and model system biology data, patient healthcare records, and clinical trials' data. In this new technological paradigm, researchers use virtual space and computing power from existing commercial or not-for-profit cloud service providers to access, store, and analyze data via different application programming interfaces. Cloud services are an alternative to the need of larger data storage; however, they raise different ethical, legal, and social issues. The purpose of this Commentary is to summarize how cloud computing can contribute to bioinformatics-based drug discovery and to highlight some of the outstanding legal, ethical, and social issues that are inherent in the use of cloud services. PMID:25195583

  13. Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention

    PubMed Central

    Martinson, Holly A.; Lyons, Traci R.; Giles, Erin D.; Borges, Virginia F.; Schedin, Pepper

    2014-01-01

    The magnitude of the breast cancer problem implores researchers to aggressively investigate prevention strategies. However, several barriers currently reduce the feasibility of breast cancer prevention. These barriers include the inability to accurately predict future breast cancer diagnosis at the individual level, the need for improved understanding of when to implement interventions, uncertainty with respect to optimal duration of treatment, and negative side effects associated with currently approved chemoprevention therapies. None-the-less, the unique biology of the mammary gland, with its postnatal development and conditional terminal differentiation, may permit the resolution of many of these barriers. Specifically, lifecycle-specific windows of breast cancer risk have been identified that may be amenable to risk-reducing strategies. Here, we argue for prevention research focused on two of these lifecycle windows of risk: postpartum mammary gland involution and peri-menopause. We provide evidence that these windows are highly amenable to targeted, limited duration treatments. Such approaches could result in the prevention of postpartum and postmenopausal breast cancers, correspondingly. PMID:23664839

  14. Aortic dissection and sport: physiologic and clinical understanding provide an opportunity to save young lives.

    PubMed

    Mayerick, C; Carré, F; Elefteriades, J

    2010-10-01

    Understanding the relationship between acute type A aortic dissection and sport is crucial to prevent sudden cardiac death in seemingly healthy young individuals. Aerobic exercise produces only a modest rise in arterial blood pressure (140-160 mmHg) except at the highest levels of exertion, at which pressures between 180-220 mmHg are reached. Weight training, on the other hand, routinely produces acute rises in blood pressure to over 300 mmHg. This presents a danger for individuals with an unknown aortic aneurysm; the deteriorated mechanical properties of the aortic wall resulting from aneurysmal enlargement increase the susceptibility to aortic rupture when the high wall coincident with exertion exceeds the tensile strength of the aortic wall. Investigations by our group into the inciting events leading up to dissection have demonstrated a causal link between extreme exertion, severe emotional stress, and acute type A aortic dissection. Since aortic enlargement is often unknown to persons participating in weight training, especially in the youth population, a ìSnapShot Echocardiogramî screening program is been proposed; such a pilot program will raise awareness of the importance of pre-participation cardiac screening and allow for early detection of aneurysms as a means of preventing this ìsilent killerî from striking. As strong supporters of the numerous benefits of weight training, we encourage this activity in individuals without aneurysm; without aneurysm, wall tension does not reach dangerous levels, even at extremes of exertion. For individuals with known aortic dilatation, we recommend a program that limits their lifting to 50% of body weight in the bench press or equivalent level of perceived exertion for other specific strength exercises. PMID:20924328

  15. Post-copulatory opportunities for sperm competition and cryptic female choice provide no offspring fitness benefits in externally fertilizing salmon.

    PubMed

    Lumley, Alyson J; Diamond, Sian E; Einum, Sigurd; Yeates, Sarah E; Peruffo, Danielle; Emerson, Brent C; Gage, Matthew J G

    2016-03-01

    There is increasing evidence that females can somehow improve their offspring fitness by mating with multiple males, but we understand little about the exact stage(s) at which such benefits are gained. Here, we measure whether offspring fitness is influenced by mechanisms operating solely between sperm and egg. Using externally fertilizing and polyandrous Atlantic salmon (Salmo salar), we employed split-clutch and split-ejaculate in vitro fertilization experiments to generate offspring using designs that either denied or applied opportunities for sperm competition and cryptic female choice. Following fertilizations, we measured 140 days of offspring fitness after hatch, through growth and survival in hatchery and near-natural conditions. Despite an average composite mortality of 61%, offspring fitness at every life stage was near-identical between groups fertilized under the absence versus presence of opportunities for sperm competition and cryptic female choice. Of the 21 551 and 21 771 eggs from 24 females fertilized under monandrous versus polyandrous conditions, 68% versus 67.8% survived to the 100-day juvenile stage; sub-samples showed similar hatching success (73.1% versus 74.3%), had similar survival over 40 days in near-natural streams (57.3% versus 56.2%) and grew at similar rates throughout. We therefore found no evidence that gamete-specific interactions allow offspring fitness benefits when polyandrous fertilization conditions provide opportunities for sperm competition and cryptic female choice. PMID:27069665

  16. Post-copulatory opportunities for sperm competition and cryptic female choice provide no offspring fitness benefits in externally fertilizing salmon.

    PubMed

    Lumley, Alyson J; Diamond, Sian E; Einum, Sigurd; Yeates, Sarah E; Peruffo, Danielle; Emerson, Brent C; Gage, Matthew J G

    2016-03-01

    There is increasing evidence that females can somehow improve their offspring fitness by mating with multiple males, but we understand little about the exact stage(s) at which such benefits are gained. Here, we measure whether offspring fitness is influenced by mechanisms operating solely between sperm and egg. Using externally fertilizing and polyandrous Atlantic salmon (Salmo salar), we employed split-clutch and split-ejaculate in vitro fertilization experiments to generate offspring using designs that either denied or applied opportunities for sperm competition and cryptic female choice. Following fertilizations, we measured 140 days of offspring fitness after hatch, through growth and survival in hatchery and near-natural conditions. Despite an average composite mortality of 61%, offspring fitness at every life stage was near-identical between groups fertilized under the absence versus presence of opportunities for sperm competition and cryptic female choice. Of the 21 551 and 21 771 eggs from 24 females fertilized under monandrous versus polyandrous conditions, 68% versus 67.8% survived to the 100-day juvenile stage; sub-samples showed similar hatching success (73.1% versus 74.3%), had similar survival over 40 days in near-natural streams (57.3% versus 56.2%) and grew at similar rates throughout. We therefore found no evidence that gamete-specific interactions allow offspring fitness benefits when polyandrous fertilization conditions provide opportunities for sperm competition and cryptic female choice.

  17. Post-copulatory opportunities for sperm competition and cryptic female choice provide no offspring fitness benefits in externally fertilizing salmon

    PubMed Central

    Lumley, Alyson J.; Diamond, Sian E.; Einum, Sigurd; Yeates, Sarah E.; Peruffo, Danielle; Emerson, Brent C.; Gage, Matthew J. G.

    2016-01-01

    There is increasing evidence that females can somehow improve their offspring fitness by mating with multiple males, but we understand little about the exact stage(s) at which such benefits are gained. Here, we measure whether offspring fitness is influenced by mechanisms operating solely between sperm and egg. Using externally fertilizing and polyandrous Atlantic salmon (Salmo salar), we employed split-clutch and split-ejaculate in vitro fertilization experiments to generate offspring using designs that either denied or applied opportunities for sperm competition and cryptic female choice. Following fertilizations, we measured 140 days of offspring fitness after hatch, through growth and survival in hatchery and near-natural conditions. Despite an average composite mortality of 61%, offspring fitness at every life stage was near-identical between groups fertilized under the absence versus presence of opportunities for sperm competition and cryptic female choice. Of the 21 551 and 21 771 eggs from 24 females fertilized under monandrous versus polyandrous conditions, 68% versus 67.8% survived to the 100-day juvenile stage; sub-samples showed similar hatching success (73.1% versus 74.3%), had similar survival over 40 days in near-natural streams (57.3% versus 56.2%) and grew at similar rates throughout. We therefore found no evidence that gamete-specific interactions allow offspring fitness benefits when polyandrous fertilization conditions provide opportunities for sperm competition and cryptic female choice. PMID:27069665

  18. 34 CFR 647.4 - What activities and services may a project provide?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the following services and activities: (a) Opportunities for research or other scholarly activities at... effective preparation for doctoral study. (b) Summer internships. (c) Seminars and other...

  19. Private Training Providers: Their Characteristics and Training Activities. Support Document

    ERIC Educational Resources Information Center

    Harris, Roger; Simons, Michele; McCarthy, Carmel

    2006-01-01

    This document was produced by the authors based on their research for the report, "Private Training Providers: Their Characteristics and Training Activities," [ED495181] and is an added resource for further information. That study examined the nature of the training activity of private registered training organisations (RTOs) offered to Australian…

  20. Physical Activity at Daycare: Childcare Providers' Perspectives for Improvements

    ERIC Educational Resources Information Center

    Tucker, Patricia; van Zandvoort, Melissa M.; Burke, Shauna M.; Irwin, Jennifer D.

    2011-01-01

    In London, Ontario, approximately 45 percent of preschoolers are insufficiently active.With the large number of preschoolers who attend childcare (54%), and the low levels of physical activity among preschool-aged children, daycare centers may be an appropriate avenue to intervene. This study sought to collect childcare providers' suggestions for…

  1. Opportunities for public health to increase physical activity among youths.

    PubMed

    Piercy, Katrina L; Dorn, Joan M; Fulton, Janet E; Janz, Kathleen F; Lee, Sarah M; McKinnon, Robin A; Pate, Russell R; Pfeiffer, Karin A; Young, Deborah Rohm; Troiano, Richard P; Lavizzo-Mourey, Risa

    2015-03-01

    Despite the well-known benefits of youths engaging in 60 or more minutes of daily physical activity, physical inactivity remains a significant public health concern. The 2008 Physical Activity Guidelines for Americans (PAG) provides recommendations on the amount of physical activity needed for overall health; the PAG Midcourse Report (2013) describes effective strategies to help youths meet these recommendations. Public health professionals can be dynamic change agents where youths live, learn, and play by changing environments and policies to empower youths to develop regular physical activity habits to maintain throughout life. We have summarized key findings from the PAG Midcourse Report and outlined actions that public health professionals can take to ensure that all youths regularly engage in health-enhancing physical activity. PMID:25602864

  2. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY... Web site for announcement of Federal assistance opportunities. Opportunities for assistance will also... program? Notice of opportunities for assistance to conduct an appraisal investigation or a...

  3. Health Care Providers' Knowledge and Practice Gap towards Joint Zoonotic Disease Surveillance System: Challenges and Opportunities, Gomma District, Southwest Ethiopia

    PubMed Central

    Sime, Abiot Girma; Hajito, Kifle Woldemichael; Gelalacha, Benti Deresa

    2016-01-01

    Background. Health care providers play a crucial role for realization of joint zoonotic diseases surveillance by human and animal health sectors, yet there is limited evidence. Hence, this study aimed to determine knowledge and practice gap of health care providers towards the approach for Rabies and Anthrax in Southwest Ethiopia. Methods. A cross-sectional survey was conducted from December 16, 2014, to January 14, 2015. Eligible health care providers were considered for the study. Data were entered in to Epi-data version 3.1 and analyzed using SPSS version 20. Results. A total of 323 (92.02%) health care providers participated in the study. Three hundred sixteen (97.8%) of participants reported that both human and animal health sectors can work together for zoonotic diseases while 96.9% of them replied that both sectors can jointly conduct surveillance. One hundred seventeen (36.2%) of them reported that their respective sectors had conducted joint surveillance for zoonotic diseases. Their involvement was, however, limited to joint outbreak response. Conclusion. There is good opportunity in health care providers' knowledge even though the practice was unacceptably low and did not address all surveillance components. Therefore, formal joint surveillance structure should be in place for optimal implementation of surveillance. PMID:27579311

  4. Health Care Providers' Knowledge and Practice Gap towards Joint Zoonotic Disease Surveillance System: Challenges and Opportunities, Gomma District, Southwest Ethiopia.

    PubMed

    Gemeda, Desta Hiko; Sime, Abiot Girma; Hajito, Kifle Woldemichael; Gelalacha, Benti Deresa; Tafese, Wubit; Gebrehiwot, Tsegaye Tewelde

    2016-01-01

    Background. Health care providers play a crucial role for realization of joint zoonotic diseases surveillance by human and animal health sectors, yet there is limited evidence. Hence, this study aimed to determine knowledge and practice gap of health care providers towards the approach for Rabies and Anthrax in Southwest Ethiopia. Methods. A cross-sectional survey was conducted from December 16, 2014, to January 14, 2015. Eligible health care providers were considered for the study. Data were entered in to Epi-data version 3.1 and analyzed using SPSS version 20. Results. A total of 323 (92.02%) health care providers participated in the study. Three hundred sixteen (97.8%) of participants reported that both human and animal health sectors can work together for zoonotic diseases while 96.9% of them replied that both sectors can jointly conduct surveillance. One hundred seventeen (36.2%) of them reported that their respective sectors had conducted joint surveillance for zoonotic diseases. Their involvement was, however, limited to joint outbreak response. Conclusion. There is good opportunity in health care providers' knowledge even though the practice was unacceptably low and did not address all surveillance components. Therefore, formal joint surveillance structure should be in place for optimal implementation of surveillance. PMID:27579311

  5. Continuous quality improvement programs provide new opportunities to drive value innovation initiatives in hospital-based radiology practices.

    PubMed

    Steele, Joseph R; Schomer, Don F

    2009-07-01

    Imaging services constitute a huge portion of the of the total dollar investment within the health care enterprise. Accordingly, this generates competition among medical specialties organized along service lines for their pieces of the pie and increased scrutiny from third-party payers and government regulators. These market and political forces create challenge and opportunity for a hospital-based radiology practice. Clearly, change that creates or builds greater value for patients also creates sustainable competitive advantage for a radiology practice. The somewhat amorphous concept of quality constitutes a significant value driver for innovation in this scenario. Quality initiatives and programs seek to define and manage this amorphous concept and provide tools for a radiology practice to create or build more value. Leadership and the early adoption of these inevitable programs by a radiology practice strengthens relationships with hospital partners and slows the attrition of imaging service lines to competitors.

  6. Biological Model Development as an Opportunity to Provide Content Auditing for the Foundational Model of Anatomy Ontology

    PubMed Central

    Wang, Lucy L.; Grunblatt, Eli; Jung, Hyunggu; Kalet, Ira J.; Whipple, Mark E.

    2015-01-01

    Constructing a biological model using an established ontology provides a unique opportunity to perform content auditing on the ontology. We built a Markov chain model to study tumor metastasis in the regional lymphatics of patients with head and neck squamous cell carcinoma (HNSCC). The model attempts to determine regions with high likelihood for metastasis, which guides surgeons and radiation oncologists in selecting the boundaries of treatment. To achieve consistent anatomical relationships, the nodes in our model are populated using lymphatic objects extracted from the Foundational Model of Anatomy (FMA) ontology. During this process, we discovered several classes of inconsistencies in the lymphatic representations within the FMA. We were able to use this model building opportunity to audit the entities and connections in this region of interest (ROI). We found five subclasses of errors that are computationally detectable and resolvable, one subclass of errors that is computationally detectable but unresolvable, requiring the assistance of a content expert, and also errors of content, which cannot be detected through computational means. Mathematical descriptions of detectable errors along with expert review were used to discover inconsistencies and suggest concepts for addition and removal. Out of 106 organ and organ parts in the ROI, 8 unique entities were affected, leading to the suggestion of 30 concepts for addition and 4 for removal. Out of 27 lymphatic chain instances, 23 were found to have errors, with a total of 32 concepts suggested for addition and 15 concepts for removal. These content corrections are necessary for the accurate functioning of the FMA and provide benefits for future research and educational uses. PMID:26958311

  7. Legal considerations and cooperative opportunities for space commercial activities

    NASA Technical Reports Server (NTRS)

    Hosenball, S. N.

    1984-01-01

    It is a national policy to make the capabilities of the Space Transportation System available to a wide range of potential users. This includes its availability as a space manufacturing facility for commercial activities, which may be carried out on a reimbursable basis or as a joint endeavor with NASA, but with substantial private investment. In any high risk, long lead-time research and development activity directed towards commercialization, the protection afforded the results of the research and development under the laws relating to intellectual property rights may provide an important incentive for private investment. The policies and practices of NASA directed towards the protection of privately-established intellectual property rights involved in STS use are reviewed with particular emphasis on reimbursable launch agreements and joint endeavor agreements.

  8. Surface interactions with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportunities for safer design.

    PubMed

    Li, Ruibin; Ji, Zhaoxia; Chang, Chong Hyun; Dunphy, Darren R; Cai, Xiaoming; Meng, Huan; Zhang, Haiyuan; Sun, Bingbing; Wang, Xiang; Dong, Juyao; Lin, Sijie; Wang, Meiying; Liao, Yu-Pei; Brinker, C Jeffrey; Nel, Andre; Xia, Tian

    2014-02-25

    Growing international exploitation of rare earth oxides (REOs) for commercial and biological use has increased the possibility of human exposure and adverse health effects. Occupational exposure to rare earth materials in miners and polishers leads to a severe form of pneumoconiosis, while gadolinium-containing MRI contrast agents cause nephrogenic systemic fibrosis in patients with renal impairment. The mechanisms for inducing these adverse pro-fibrogenic effects are of considerable importance for the safety assessment of REO particles as well as presenting opportunities for safer design. In this study, using a well-prepared REO library, we obtained a mechanistic understanding of how REOs induce cellular and pulmonary damage by a compartmentalized intracellular biotransformation process in lysosomes that results in pro-fibrogenic growth factor production and lung fibrosis. We demonstrate that rare earth oxide ion shedding in acidifying macrophage lysosomes leads to biotic phosphate complexation that results in organelle damage due to stripping of phosphates from the surrounding lipid bilayer. This results in nanoparticle biotransformation into urchin shaped structures and setting in motion a series of events that trigger NLRP3 inflammasome activation, IL-1β release, TGF-β1 and PDGF-AA production. However, pretreatment of REO nanoparticles with phosphate in a neutral pH environment prevents biological transformation and pro-fibrogenic effects. This can be used as a safer design principle for producing rare earth nanoparticles for biological use.

  9. Increasing organ donor registration rates by providing an immediate and complete registration opportunity: an experimental assessment of the IIFF model.

    PubMed

    Alvaro, Eusebio M; Siegel, Jason T; Jones, Sara P

    2011-12-01

    The IIFF model of organ donation holds that the simultaneous presence of four factors directly influence donor registration: (1) immediate and complete registration opportunity (ICRO), (2) information, (3) focused engagement, and (4) favorable activation. Two field experiments examined the impact of an ICRO on organ donation registration. In Study 1, participants were at town halls where they knew organ donation was to be discussed. Registration cards were distributed and then collected at the end of the session in half of the town halls. For the other half, participants were asked to mail in completed cards. In three US cities, participants given an ICRO registered at a significantly greater rate (z = 4.865, p < 0.05). Study 2, targeting Hispanics at a swap meet, differed in that the registration impact of awareness of the availability of an ICRO was investigated. Participants made aware of an ICRO registered at a significantly greater rate (z = 4.1, p = 0.000).

  10. Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

    PubMed Central

    2014-01-01

    Growing international exploitation of rare earth oxides (REOs) for commercial and biological use has increased the possibility of human exposure and adverse health effects. Occupational exposure to rare earth materials in miners and polishers leads to a severe form of pneumoconiosis, while gadolinium-containing MRI contrast agents cause nephrogenic systemic fibrosis in patients with renal impairment. The mechanisms for inducing these adverse pro-fibrogenic effects are of considerable importance for the safety assessment of REO particles as well as presenting opportunities for safer design. In this study, using a well-prepared REO library, we obtained a mechanistic understanding of how REOs induce cellular and pulmonary damage by a compartmentalized intracellular biotransformation process in lysosomes that results in pro-fibrogenic growth factor production and lung fibrosis. We demonstrate that rare earth oxide ion shedding in acidifying macrophage lysosomes leads to biotic phosphate complexation that results in organelle damage due to stripping of phosphates from the surrounding lipid bilayer. This results in nanoparticle biotransformation into urchin shaped structures and setting in motion a series of events that trigger NLRP3 inflammasome activation, IL-1β release, TGF-β1 and PDGF-AA production. However, pretreatment of REO nanoparticles with phosphate in a neutral pH environment prevents biological transformation and pro-fibrogenic effects. This can be used as a safer design principle for producing rare earth nanoparticles for biological use. PMID:24417322

  11. Association between Social and Environmental Factors and Physical Activity Opportunities in Middle Schools

    ERIC Educational Resources Information Center

    Xu, Furong; Chepyator-Thomson, Jepkorir; Liu, Wenhao; Schmidlein, Robert

    2010-01-01

    School-based physical activity (PA) interventions impact children's PA involvement and thus opportunities and associated factors for the promotion of physical activity in children need to be examined. The purpose of this study was to examine physical education teachers' perceptions of PA opportunities available to students at the middle school…

  12. Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases

    PubMed Central

    Vegeto, Elisabetta; Benedusi, Valeria; Maggi, Adriana

    2008-01-01

    Recent studies highlight the prominent role played by estrogens in protecting the central nervous system (CNS) against the noxious consequences of a chronic inflammatory reaction. The neurodegenerative process of several CNS diseases, including Multiple Sclerosis, Alzheimer’s and Parkinson’s Diseases, is associated with the activation of microglia cells, which drive the resident inflammatory response. Chronically stimulated during neurodegeneration, microglia cells are thought to provide detrimental effects on surrounding neurons. The inhibitory activity of estrogens on neuroinflammation and specifically on microglia might thus be considered as a beneficial therapeutic opportunity for delaying the onset or progression of neurodegenerative diseases; in addition, understanding the peculiar activity of this female hormone on inflammatory signalling pathways will possibly lead to the development of selected anti-inflammatory molecules. This review summarises the evidence for the involvement of microglia in neuroinflammation and the anti-inflammatory activity played by estrogens specifically in microglia. PMID:18522863

  13. Duration of suicide process among suicide attempters and characteristics of those providing window of opportunity for intervention

    PubMed Central

    Kattimani, Shivanand; Sarkar, Siddharth; Menon, Vikas; Muthuramalingam, Avin; Nancy, Premkumar

    2016-01-01

    Background: There is limited cross-cultural literature on the duration of suicide process among attempters. Aims: The primary aim was to assess the duration of suicide process among suicide attempters attending the Crisis Intervention Clinic. We also aimed to identify the characteristics of those who reported a longer duration for this process. Methods: In this retrospective record-based study, we collected the duration of the suicidal process from the records of all the suicide attempters evaluated over a 3-year period (n = 319). Attempters were divided into four groups based on the quartile value of the duration of the suicidal process. For analysis, the characteristics of those in the last quartile with suicide process time of >120 min (n = 75) were compared with those in the first three (n = 244). Those in the last quartile were considered to provide a window of opportunity for intervention. Results: The median time for the suicidal process was 30 min (interquartile range of 5 min to 120 min). Seventy-five (23.5%) subjects belonged to the fourth quartile (duration of suicide process >120 min). A significant proportion of them came from urban areas (P = 0.011), had a diagnosis of mood disorder (P = 0.028), had visited a health professional in the recent past (P = 0.015), and had lower rates of attempt under intoxication (P = 0.005). A lesser proportion of them showed problem-focused disengagement style of coping strategy (P = 0.015). Conclusions: The suicide process time among Indian suicide attempters is short. However, a quarter of them has suicide process duration of 2 h which provides some scope for intervention. Individual and community level interventions need further evaluation for their potential efficacy in preventing the progress of the suicidal process. PMID:27695238

  14. Duration of suicide process among suicide attempters and characteristics of those providing window of opportunity for intervention

    PubMed Central

    Kattimani, Shivanand; Sarkar, Siddharth; Menon, Vikas; Muthuramalingam, Avin; Nancy, Premkumar

    2016-01-01

    Background: There is limited cross-cultural literature on the duration of suicide process among attempters. Aims: The primary aim was to assess the duration of suicide process among suicide attempters attending the Crisis Intervention Clinic. We also aimed to identify the characteristics of those who reported a longer duration for this process. Methods: In this retrospective record-based study, we collected the duration of the suicidal process from the records of all the suicide attempters evaluated over a 3-year period (n = 319). Attempters were divided into four groups based on the quartile value of the duration of the suicidal process. For analysis, the characteristics of those in the last quartile with suicide process time of >120 min (n = 75) were compared with those in the first three (n = 244). Those in the last quartile were considered to provide a window of opportunity for intervention. Results: The median time for the suicidal process was 30 min (interquartile range of 5 min to 120 min). Seventy-five (23.5%) subjects belonged to the fourth quartile (duration of suicide process >120 min). A significant proportion of them came from urban areas (P = 0.011), had a diagnosis of mood disorder (P = 0.028), had visited a health professional in the recent past (P = 0.015), and had lower rates of attempt under intoxication (P = 0.005). A lesser proportion of them showed problem-focused disengagement style of coping strategy (P = 0.015). Conclusions: The suicide process time among Indian suicide attempters is short. However, a quarter of them has suicide process duration of 2 h which provides some scope for intervention. Individual and community level interventions need further evaluation for their potential efficacy in preventing the progress of the suicidal process.

  15. The ATS Web Page Provides "Tool Boxes" for: Access Opportunities, Performance, Interfaces, Volume, Environments, "Wish List" Entry and Educational Outreach

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This viewgraph presentation gives an overview of the Access to Space website, including information on the 'tool boxes' available on the website for access opportunities, performance, interfaces, volume, environments, 'wish list' entry, and educational outreach.

  16. 75 FR 6728 - The Merit Systems Protection Board (MSPB) is Providing Notice of the Opportunity to File Amicus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    .... ACTION: Notice. SUMMARY: On January 25, 2010, the MSPB published in the Federal Register (see 75 FR 3939) a Notice of the opportunity to file amicus briefs in the matter of Crumpler v. Department of Defense... Briefs in the Matters of Conyers v. Department of Defense, Docket No. CH-0752-09-0925-I-1, and...

  17. Providing Opportunities for Student Self-Assessment: The Impact on the Acquisition of Psychomotor Skills in Occupational Therapy Students

    ERIC Educational Resources Information Center

    Jay, Julie; Owen, Antonette

    2016-01-01

    The Occupational Therapy department at the University of the Witwatersrand in South Africa is responsible for ensuring students achieve psychomotor skill proficiency, as it is an essential component of health care practice. The aim of this study was to determine whether the introduction of opportunities to afford self-evaluation better prepared…

  18. Reverse Inclusion: Providing Peer Social Interaction Opportunities to Students Placed in Self-Contained Special Education Classrooms

    ERIC Educational Resources Information Center

    Schoger, Kimberly D.

    2006-01-01

    The social and academic benefits of inclusion for students with disabilities have been well researched and well documented. Unfortunately, inclusion opportunities are limited by lack of qualified staff, logistics, scheduling and other difficulties encountered when attempting to meet students' unique needs in the general education setting. As a…

  19. An Act to Provide Employment and Training Opportunities for Youth, and to Provide for Other Improvements in Employment and Training Programs. Public Law 95-93. 95th Congress.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC.

    Enacted by Congress in August 1977 to provide employment and training opportunities for youth and to provide for other improvements in employment and training programs, this act is cited as the Youth Employment and Demonstration Projects Act of 1977. It has three titles. Title I--Young Adult Conservation Corps--amends the Comprehensive Employment…

  20. Using time-driven activity-based costing to identify value improvement opportunities in healthcare.

    PubMed

    Kaplan, Robert S; Witkowski, Mary; Abbott, Megan; Guzman, Alexis Barboza; Higgins, Laurence D; Meara, John G; Padden, Erin; Shah, Apurva S; Waters, Peter; Weidemeier, Marco; Wertheimer, Sam; Feeley, Thomas W

    2014-01-01

    As healthcare providers cope with pricing pressures and increased accountability for performance, they should be rededicating themselves to improving the value they deliver to their patients: better outcomes and lower costs. Time-driven activity-based costing offers the potential for clinicians to redesign their care processes toward that end. This costing approach, however, is new to healthcare and has not yet been systematically implemented and evaluated. This article describes early time-driven activity-based costing work at several leading healthcare organizations in the United States and Europe. It identifies the opportunities they found to improve value for patients and demonstrates how this costing method can serve as the foundation for new bundled payment reimbursement approaches. PMID:25647962

  1. Using time-driven activity-based costing to identify value improvement opportunities in healthcare.

    PubMed

    Kaplan, Robert S; Witkowski, Mary; Abbott, Megan; Guzman, Alexis Barboza; Higgins, Laurence D; Meara, John G; Padden, Erin; Shah, Apurva S; Waters, Peter; Weidemeier, Marco; Wertheimer, Sam; Feeley, Thomas W

    2014-01-01

    As healthcare providers cope with pricing pressures and increased accountability for performance, they should be rededicating themselves to improving the value they deliver to their patients: better outcomes and lower costs. Time-driven activity-based costing offers the potential for clinicians to redesign their care processes toward that end. This costing approach, however, is new to healthcare and has not yet been systematically implemented and evaluated. This article describes early time-driven activity-based costing work at several leading healthcare organizations in the United States and Europe. It identifies the opportunities they found to improve value for patients and demonstrates how this costing method can serve as the foundation for new bundled payment reimbursement approaches.

  2. 77 FR 69604 - Agency Information Collection Activities; Comment Request; Educational Opportunity Centers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Agency Information Collection Activities; Comment Request; Educational Opportunity Centers Program (EOC... respondents, including through the use of information technology. Please note that written comments received in response to this notice will be considered public records. Title of Collection:...

  3. Opportunities Abound for Moving Around: Get Active, Wherever You Are

    MedlinePlus

    ... get to grocery stores, shops, and even public transportation. “Our environments have become less friendly to being ... they walk.” Research also shows that taking public transportation—like buses and trains—can help boost activity. ...

  4. Proveer igualdad de oportunidades educativas para los estudiantes con conocimientos limitados del idioma ingles (Providing Equality of Educational Opportunity for Students with Limited Knowledge of the English Language).

    ERIC Educational Resources Information Center

    Office for Civil Rights (ED), Washington, DC.

    This brochure, entirely in Spanish, provides information on federal policy concerning equal educational opportunity for limited-English-proficient (LEP) individuals. It first summarizes the provisions of Title VI of the 1964 Civil Rights Act, and the subsequent major Civil Rights Office directives concerning that legislation. It then outlines…

  5. How Can I Clarify My Responsibility as a Headteacher as I Provide Opportunities to Enable All Children in the School to Create Talents?

    ERIC Educational Resources Information Center

    Cripps, Louise

    2013-01-01

    In this account I explore and clarify my responsibility as I explain how I have come to my current understanding of talent creation, and why I feel it is so important to develop an inclusive approach to talent creation which provides opportunities for all the children to develop talents through their time at school, and to have them recognised and…

  6. Right Back at 'Cha--Boomerang Activity Provides Educational Returns

    ERIC Educational Resources Information Center

    Campbell, Brian

    2012-01-01

    Motivating students to get actively involved in the curriculum and understand the application of academic content has been a challenge for many educators. Technology education instructors have traditionally had little difficulty showing their students the connection between their classroom and lab learning and a practical application of the skills…

  7. Challenges and opportunities for promoting physical activity in the workplace.

    PubMed

    Marshall, A L

    2004-04-01

    Although there would appear to be considerable potential for improving the health, productivity and quality of life of the Australian workforce through workplace physical activity (PA) promotion programs, the scientific evidence that such programs are effective is limited. This review appraises the quality of intervention studies conducted since 1997. Most studies included volunteer participants, who were either sufficiently motivated to change their behaviour or already active. Interventions that focused on corporate-fitness type programs and the provision of generic health education programs were not effective in terms of adequate participation rates and sustained behaviour change. The more successful individually-based programs were those which tailored materials to individual needs. The greatest potential for influencing the overall workforce appeared to be programs that included less 'organised' approaches and promoted incidental PA within and around the workplace. Future programs should; incorporate contemporary theories of behaviour and organisational change; emphasise linkages between the workplace and external settings; expand the profile of programs to address workplace culture; and encourage management support for behavioural adjustments to the organisation. There is a need for greater understanding and evaluation of desirable employer-related outcomes, such as reduced absenteeism, job stress and turnover and improved productivity and job satisfaction, coupled with the exploration of how these factors may relate to PA promotion and adoption. Finally, more in-depth evaluation strategies and complete descriptions of intervention programs are required, in order to identify the most effective strategies. PMID:15214603

  8. Weight Management-Related Assessment and Counseling by Primary Care Providers in an Area of High Childhood Obesity Prevalence: Current Practices and Areas of Opportunity

    PubMed Central

    Nelson, Jennifer M.; Vos, Miriam B.; Walsh, Stephanie M.; O'Brien, Lauren A.

    2015-01-01

    Abstract Background: Childhood obesity in Georgia exceeds the national rate. The state's pediatric primary care providers (PCPs) are well positioned to support behavior change, but little is known about provider perceptions and practices regarding this role. Purpose: The aim of this study was to assess and compare weight-management–related counseling perceptions and practices among Georgia's PCPs. Methods: In 2012–2013, 656 PCPs (265 pediatricians, 143 family practice physicians [FPs], and 248 nurse practitioners/physician assistants [NP/PAs]) completed a survey regarding weight-management–related practices at well-child visits before their voluntary participation in a free training on patient-centered counseling and child weight management. Data were analyzed in 2014. Likert scales were used to quantify responses from 1 (strongly disagree or never) to 5 (strongly agree or always). Responses of 4 and 5 responses were combined to denote agreement or usual practice. Chi-squared analyses tested for independent associations between pediatricians and others. Statistical significance was determined using two-sided tests and p value <0.05. Results: The majority of PCPs assessed fruit and vegetable intake (83%) and physical activity (78%), but pediatricians were more likely than FPs and NP/PAs to assess beverage intake (96% vs. 82–87%; p≤0.002) and screen time (86% vs. 74–75%; p≤0.003). Pediatricians were also more likely to counsel patients on lifestyle changes (88% vs. 71%; p<0.001) and to track progress (50% vs. 35–39%; p<0.05). Though all PCPs agreed that goal setting is an effective motivator (88%) and that behavior change increases with provider encouragement (85%), fewer were confident in their ability to counsel (72%). Conclusions: Our results show that many PCPS in Georgia, particularly pediatricians, have incorporated weight management counseling into their practice; however, important opportunities to strengthen these efforts by targeting known

  9. Providing accurate near real-time fire alerts for Protected Areas through NASA FIRMS: Opportunities and Challenges

    NASA Astrophysics Data System (ADS)

    Ilavajhala, S.; Davies, D.; Schmaltz, J. E.; Wong, M.; Murphy, K. J.

    2013-12-01

    The NASA Fire Information for Resource Management System (FIRMS) is at the forefront of providing global near real-time (NRT) MODIS thermal anomalies / hotspot location data to end-users . FIRMS serves the data via an interactive Web GIS named Web Fire Mapper, downloads of NRT active fire, archive data downloads for MODIS hotspots dating back to 1999 and a hotspot email alert system The FIRMS Email Alerts system has been successfully alerting users of fires in their area of interest in near real-time and/or via daily and weekly email summaries, with an option to receive MODIS hotspot data as a text file (CSV) attachment. Currently, there are more than 7000 email alert subscriptions from more than 100 countries. Specifically, the email alerts system is designed to generate and send an email alert for any region or area on the globe, with a special focus on providing alerts for protected areas worldwide. For many protected areas, email alerts are particularly useful for early fire detection, monitoring on going fires, as well as allocating resources to protect wildlife and natural resources of particular value. For protected areas, FIRMS uses the World Database on Protected Areas (WDPA) supplied by United Nations Environment Program - World Conservation Monitoring Centre (UNEP-WCMC). Maintaining the most up-to-date, accurate boundary geometry for the protected areas for the email alerts is a challenge as the WDPA is continuously updated due to changing boundaries, merging or delisting of certain protected areas. Because of this dynamic nature of the protected areas database, the FIRMS protected areas database is frequently out-of-date with the most current version of WDPA database. To maintain the most up-to-date boundary information for protected areas and to be in compliance with the WDPA terms and conditions, FIRMS needs to constantly update its database of protected areas. Currently, FIRMS strives to keep its database up to date by downloading the most recent

  10. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  11. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  12. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  13. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  14. 76 FR 32236 - Merit Systems Protection Board (MSPB or Board) Provides Notice of Opportunity To File Amicus...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... agency further asserts that in 1984 it provided notice in the Federal Register that it would be... called for the use of the ``tie-breaker'' principle that has been in effect from 1984 through the...

  15. The GILDA t-Infrastructure: grid training activities in Africa and future opportunities

    NASA Astrophysics Data System (ADS)

    Ardizzone, V.; Barbera, R.; Ciuffo, L.; Giorgio, E.

    2009-04-01

    Scientists, educators, and students from many parts of the worlds are not able to take advantage of ICT because the digital divide is growing and prevents less developed countries to exploit its benefits. Instead of becoming more empowered and involved in worldwide developments, they are becoming increasingly marginalised as the world of education and science becomes increasingly Internet-dependent. The Grid Infn Laboratory for Dissemination Activities (GILDA) spreads since almost five years the awareness of Grid technology to a large audience, training new communities and fostering new organisations to provide resources. The knowledge dissemination process guided by the training activities is a key factor to ensure that all users can fully understand the characteristics of the Grid services offered by large existing e-Infrastructure. GILDA is becoming a "de facto" standard in training infrastructures (t-Infrastructures) and it is adopted by many grid projects worldwide. In this contribution we will report on the latest status of GILDA services and on the training activities recently carried out in sub-Saharan Africa (Malawi and South Africa). Particular care will be devoted to show how GILDA can be "cloned" to satisfy both education and research demands of African Organisations. The opportunities to benefit from GILDA in the framework of the EPIKH project as well as the plans of the European Commission on grid training and education for the 2010-2011 calls of its 7th Framework Programme will be presented and discussed.

  16. 45 CFR 100.8 - How does the Secretary provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 100.8 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF HEALTH AND HUMAN SERVICES PROGRAMS AND ACTIVITIES § 100.8 How does the Secretary... the review, coordination, and communication with the Department have been delegated. (c)...

  17. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  18. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  19. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  20. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  1. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  2. 24 CFR 52.8 - How does the Secretary provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false How does the Secretary provide...? 52.8 Section 52.8 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT PROGRAMS...

  3. Design of brain imaging agents for positron emission tomography: do large bioconjugates provide an opportunity for in vivo brain imaging?

    PubMed

    Schirrmacher, Ralf; Bernard-Gauthier, Vadim; Reader, Andrew; Soucy, Jean-Paul; Schirrmacher, Esther; Wängler, Björn; Wängler, Carmen

    2013-09-01

    The development of brain imaging agents for positron emission tomography and other in vivo imaging modalities mostly relies on small compounds of low MW as a result of the restricted transport of larger molecules, such as peptides and proteins, across the blood-brain barrier. Besides passive transport, only a few active carrier mechanisms, such as glucose transporters and amino acid transporters, have so far been exploited to mediate the accumulation of imaging probes in the brain. An important question for the future is whether some of the abundant active carrier systems located at the blood-brain barrier can be used to shuttle potential, but non-crossing, imaging agents into the brain. What are the biological and chemical constrictions toward such bioconjugates and is it worthwhile to persue such a delivery strategy?

  4. Restricting opportunities to be active during school time: do children compensate by increasing physical activity levels after school?

    PubMed

    Dale, D; Corbin, C B; Dale, K S

    2000-09-01

    Opportunities for children to be physically active during school time are sparse and becoming increasingly so. The purpose of this investigation was to determine if children would compensate for school days (9 a.m.-3 p.m.) of restricted physical activity opportunities by increasing activity levels after school (3 p.m.-7:30 p.m.). Third and fourth grade children (N = 76) each wore a CSA accelerometer for 4 nonconsecutive days. Two days were categorized as active--during school, all children participated in outdoor recess and physical education class. Two days were categorized as restricted--all children spent their recess time indoors at a computer terminal, and no physical education class was scheduled. Dependent t tests revealed that children did not compensate for a sedentary school day by increasing their levels of physical activity after school. In fact, average movement counts per minute were higher in the 3 p.m.-7:30 p.m. period following the active day (525 counts.min-1) versus the restricted day (186 counts.min-1). These findings suggest cause for concern if children's opportunities to be active within school time are limited. Several reasons are given as to why children did not compensate or "make up" for the physical activity opportunities missed during the restricted school day.

  5. Efficiency of Energy Use in the United States: Transportation, space heating, and air conditioning provide opportunities for large energy savings.

    PubMed

    Hirst, E; Moyers, J C

    1973-03-30

    We described three uses of energy for which greater efficiency is feasible: transportation, space heating, and air conditioning. Shifts to less energy-intensive transportation modes could substantially reduce energy consumption; the magnitude of such savings would, of course, depend on the extent of such shifts and possible load factor changes. The hypothetical transportation scenario described here results in a 22 percent savings in energy for transportation in 1970, a savings of 2800 trillion Btu. To the homeowner, increasing the amount of building insulation and, in some cases, adding storm windows would reduce energy consumption and provide monetary savings. If all homes in 1970 had the "economic optimum" amount of insulation, energy consumption for residential heating would have been 42 percent less than if the homes were insulated to meet the pre-1971 FHA standards, a savings of 3100 trillion Btu. Increased utilization of energy-efficient air conditioners and of building insulation would provide significant energy savings and help to reduce peak power demands during the summer. A 67 percent increase in energy efficiency for room air conditioners would have saved 15.8 billion kilowatt-hours in 1970. In conclusion, it is possible-from an engineering point of view-to effect considerable energy savings in the United States. Increases in the efficiency of energy use would provide desired end results with smaller energy inputs. Such measures will not reduce the level of energy consumption, but they could slow energy growth rates.

  6. Healthy food choices and physical activity opportunities in two contrasting Alabama cities.

    PubMed

    Bovell-Benjamin, A C; Hathorn, C S; Ibrahim, S; Gichuhi, P N; Bromfield, E M

    2009-06-01

    Food and physical activity access and availability in two contrasting cities in Alabama were investigated. An in-outlet, observational, cross-sectional design was utilized to assess the opportunities for healthy food choices and physical activity. Thirty retail food outlets and 29 physical activity outlets were inventoried. None of the convenience stores carried frozen, low-sodium or dark-green, yellow vegetables, low-fat milk or yogurt, low-sodium and low-fat cheese, while none of the supermarkets in Tuskegee stocked low-sodium vegetables. In Tuskegee, the single public recreational area, which offered activities such as basketball, fees ranged from $25 to $35/month. Tuskegee has a shortage of "chain" supermarkets and a dominance of convenience stores which stocked few healthy foods. Overall, there are limited opportunities for healthy food and physical activity choices, which could be a barrier for chronic disease prevention efforts.

  7. The ICESat-2 Mission: Concept, Pre-Launch Activities, and Opportunities

    NASA Technical Reports Server (NTRS)

    Markus, Thorsten; Neumann, Tom; Csatho, Beata M.

    2011-01-01

    Ice sheet and sea level changes have been explicitly identified as a priority in the President's Climate Change Science Program, the Arctic Climate Impact Assessment, the 4th Assessment Report of the IPee and other national and international policy documents. Following recommendations from the National Research Council for an ICESat follow-on mission, the ICESat-2 mission is now under development for launch in early 2016. The primary aims of the ICESat-2 mission are to continue measurements of sea-ice thickness change, and ice sheet elevation changes at scales from outlet glaciers to the entire ice sheet as established by ICES at. In contrast to ICES at, ICESat-2 will employ a 6-beam micro-pulse laser photon-counting approach. The current concept uses a high repetition rate (10 kHz; equivalent to 70 cm on the ground) low-power laser in conjunction with single-photon sensitive detectors to measure range using approximately 532nm (green) light. The concept will enable the generation of seasonal maps of ice sheet elevation of Greenland and Antarctica, monthly maps of sea ice thickness of the polar ocean, a dense map of land elevation (2 km track spacing at the equator after two years) enabling the determination of canopy height, as well as ocean heights. While the mission has been optimized for cryospheric science and vast amount of high precision elevation measurements taken over land and over the ocean as well as of the atmosphere will provide scientists with a wealth of opportunities to explore the utility of ICESat-2. Those will range from the retrieval of cloud properties, to river stages, to snow cover, to land use changes and more. The presentation will review the measurement concept and physical principles of ICESat-2, current and planned activities to assess instrument performance and develop geophysical algorithms, as well as potential opportunities outside the main objectives of ICESat-2.

  8. [Environmental factors. Opportunities and barriers for physical activity and healthy eating among children and adolescents].

    PubMed

    Huybrechts, I; De Bourdeaudhuij, I; Buck, C; De Henauw, S

    2010-07-01

    While genetic factors play a role in the development of obesity, its dramatic increase in prevalence over the past few years strongly suggests an important environmental role. The results of a review on environmental opportunities and barriers for physical activity and dietary intake influencing the obesity epidemic among children and adolescents are presented. Although evidence clearly shows the impact of the environment on obesity-related lifestyle factors among children, evidence for effective strategies combating this obesogenic environment is scarce. Interventions aiming to change environmental factors to reduce childhood obesity may include providing extra sporting facilities and healthy foods/meals at school (e.g., provision of fruit), efforts to improve safety and accessibility of walking, cycling, and play areas, while at the same time attempting to influence social values attached to weight, food, or physical activity. Some level of institutionalization of systems that support the desired changes is required to sustain long-term environmental changes (e.g., ban of softdrinks at school). Better-designed and -conducted research on the true importance of environmental factors for obesogenic behavioral change is needed to achieve success of large-scale environmental change interventions.

  9. The Effect of Active Support Training on Engagement, Opportunities for Choice, Challenging Behaviour and Support Needs

    ERIC Educational Resources Information Center

    Koritsas, Stella; Iacono, Teresa; Hamilton, David; Leighton, Daniel

    2008-01-01

    Background: The aim of this study was to evaluate active support (AS) training and to investigate changes to perceived engagement in domestic tasks, opportunities for choice, frequency of challenging behaviour, and level of support needs. Method: Participants were 12 adults with ID aged 27-57 years (M = 37 years) residing in three group homes, and…

  10. Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

    PubMed

    Cole, Jennifer E; Astola, Nagore; Cribbs, Adam P; Goddard, Michael E; Park, Inhye; Green, Patricia; Davies, Alun H; Williams, Richard O; Feldmann, Marc; Monaco, Claudia

    2015-10-20

    Atherosclerosis is the major cause of cardiovascular disease (CVD), the leading cause of death worldwide. Despite much focus on lipid abnormalities in atherosclerosis, it is clear that the immune system also has important pro- and antiatherogenic functions. The enzyme indoleamine-2,3-dioxygenase (IDO) catalyses degradation of the essential amino acid tryptophan into immunomodulatory metabolites. How IDO deficiency affects immune responses during atherogenesis is unknown and we explored potential mechanisms in models of murine and human atherosclerosis. IDO deficiency in hypercholesterolemic ApoE(-/-) mice caused a significant increase in lesion size and surrogate markers of plaque vulnerability. No significant changes in cholesterol levels were observed but decreases in IL-10 production were found in the peripheral blood, spleen and lymph node B cells of IDO-deficient compared with IDO-competent ApoE(-/-) mice. 3,4,-Dimethoxycinnamoyl anthranilic acid (3,4-DAA), an orally active synthetic derivative of the tryptophan metabolite anthranilic acid, but not l-kynurenine, enhanced production of IL-10 in cultured splenic B cells. Finally, 3,4-DAA treatment reduced lesion formation and inflammation after collar-induced arterial injury in ApoE(-/-) mice, and reduced cytokine and chemokine production in ex vivo human atheroma cell cultures. Our data demonstrate that endogenous production of tryptophan metabolites via IDO is an essential feedback loop that controls atherogenesis and athero-inflammation. We show that the IDO pathway induces production of IL-10 in B cells in vivo and in vitro, suggesting that IDO may induce immunoregulatory functions of B cells in atherosclerosis. The favorable effects of anthranilic acid derivatives in atherosclerosis indicate a novel approach toward therapy of CVD.

  11. Does global gene expression analysis in type 2 diabetes provide an opportunity to identify highly promising drug targets?

    PubMed

    Buechler, C; Schäffler, A

    2007-12-01

    The recent technological advances in high-throughput gene expression analysis allow the simultaneous investigation of thousands of genes. These technologies represent promising tools for the identification of new drug targets and considerable progress has been achieved in cancer research where microarray data provide a basis to design new drugs and to predict adverse reactions and the efficacy of chemotherapy. The metabolic syndrome represents a cluster of disorders including high blood pressure, insulin resistance/type 2 diabetes mellitus, visceral obesity and dyslipidaemia with fatty liver disease being a common associated complication. High-throughput gene expression analyses using GeneChips, microarrays and serial analysis of gene expression (SAGE) have been applied to study global gene expression in insulin resistance/type 2 diabetes mellitus. Type 2 diabetes mellitus is a multifactorial and polygenic disease by which several organs are affected. Therefore, the identification of both, disease causing and therapeutically relevant target genes is an ambitious challenge. In the present review we focus on genomic approaches that used biopsies from human skeletal muscle, liver and adipose tissue, the main organs affected by insulin resistance. Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators are decreased in skeletal muscle in insulin resistance accounting for the reduced expression of genes involved in mitochondrial oxidative phosphorylation. Hepatic steatosis is also linked to alterations in mitochondrial phosphorylation and oxidative metabolism. An up regulation of pro-inflammatory genes can be detected in early stages of fatty liver disease without histological signs of inflammation. Impaired adipogenesis, intra-adipose accumulation of macrophages and a sustained release of inflammatory and acute phase proteins are characteristic features of adipose tissue in obesity and may aggravate systemic insulin resistance.

  12. The Ford Transfer Opportunities Project at LaGuardia: Report on Activities.

    ERIC Educational Resources Information Center

    La Guardia Community Coll., Long Island City, NY.

    In September 1983, LaGuardia Community College (LCC) received a grant from the Ford Foundation's Urban Community Colleges Transfer Opportunities Program. By May 31, 1984, the following achievements had been made: (1) a model for providing students with basic transfer information was developed and tested; (2) the corporate community was brought…

  13. Energy Problems Provide Job Opportunities.

    ERIC Educational Resources Information Center

    Moore, Allen B.

    In response to the problems created by a diminishing energy supply but an increasing energy demand, this second in a series of national reports studies the linkage of vocational education and energy. Through an examination of selected literature with reference to types of energy resources, the author identifies the emerging occupations related to…

  14. Analysis of near-term production and market opportunities for hydrogen and related activities

    SciTech Connect

    Mauro, R.; Leach, S.

    1995-09-01

    This paper summarizes current and planned activities in the areas of hydrogen production and use, near-term venture opportunities, and codes and standards. The rationale for these efforts is to assess industry interest and engage in activities that move hydrogen technologies down the path to commercialization. Some of the work presented in this document is a condensed, preliminary version of reports being prepared under the DOE/NREL contract. In addition, the NHA work funded by Westinghouse Savannah River Corporation (WSRC) to explore the opportunities and industry interest in a Hydrogen Research Center is briefly described. Finally, the planned support of and industry input to the Hydrogen Technical Advisory Panel (HTAP) on hydrogen demonstration projects is discussed.

  15. Expanding Voluntary Active-learning Opportunities for Pharmacy Students in a Respiratory Physiology Module

    PubMed Central

    Ernst, Hardy; Colthorpe, Kay

    2008-01-01

    Objectives To expand voluntary active-learning opportunities for bachelor of pharmacy students enrolled in a third-year human physiology and pharmacology course and determine whether the additional course components improved learning outcomes. Design Additional voluntary active-learning opportunities including a large-class tutorial, additional formative assessment, and an online discussion were added to the Respiratory Physiology Module of the course. Examination scores were compared with those from previous years. A questionnaire was administered to assess students' perception of the active-learning components. Assessment Mean examination scores increased from 69.3% ± 24.4% in 2003 to 88.9% ± 13.4% in 2004 and 86.9% ± 17.6% in 2005, after the addition of the active-learning components. Students' overall perception of the value of the active-learning activities was positive. Summary The addition of voluntary active-learning course components to a required pharmacy course resulted in improved student examination scores, and decreased failure rate, and were accomplished at low cost and with little additional staff time. PMID:18483596

  16. Synergistic Opportunities for the Geostationary Satellite Constellation: Status of the CEOS Activity

    NASA Astrophysics Data System (ADS)

    Al-Saadi, J. A.; Zehner, C.

    2012-12-01

    overlaps with each geostationary satellite over 30N - 60N, adding opportunities for intercalibration many times per day. The development of common data products, data distribution protocols, and calibration strategies will synergistically enable critically needed understanding of the interactions between regional and global atmospheric composition. Common air quality trace gas products will be tropospheric column O3, NO2, HCHO, and SO2 nominally at 8 km spatial resolution and 1 hour temporal frequency. Detection of aerosols in the UV will allow absorbing aerosols to be distinguished from total aerosol optical depth, providing information on aerosol speciation and particularly relevant to the air quality/climate interface associated with aerosol radiative forcing. Such activities directly address societal benefit areas of the Global Earth Observation System of Systems (GEOSS), including Health, Energy, Climate, Disasters, and Ecosystems, and are responsive to the requirements of each mission to provide advanced user services and societal benefits in their own regions.

  17. Lost Opportunities to Reduce Periconception HIV Transmission: Safer Conception Counseling By South African Providers Addresses Perinatal but not Sexual HIV Transmission

    PubMed Central

    Milford, Cecilia; Kaida, Angela; Ehrlich, Matthew J.; Ng, Courtney; Greener, Ross; Mosery, F. N.; Harrison, Abigail; Psaros, Christina; Safren, Steven A.; Bajunirwe, Francis; Wilson, Ira B.; Bangsberg, David R.; Smit, Jennifer A.

    2014-01-01

    Introduction: Safer conception strategies create opportunities for HIV-serodiscordant couples to realize fertility goals and minimize periconception HIV transmission. Patient–provider communication about fertility goals is the first step in safer conception counseling. Methods: We explored provider practices of assessing fertility intentions among HIV-infected men and women, attitudes toward people living with HIV (PLWH) having children, and knowledge and provision of safer conception advice. We conducted in-depth interviews (9 counselors, 15 nurses, 5 doctors) and focus group discussions (6 counselors, 7 professional nurses) in eThekwini District, South Africa. Data were translated, transcribed, and analyzed using content analysis with NVivo10 software. Results: Among 42 participants, median age was 41 (range, 28–60) years, 93% (39) were women, and median years worked in the clinic was 7 (range, 1–27). Some providers assessed women's, not men's, plans for having children at antiretroviral therapy initiation, to avoid fetal exposure to efavirenz. When conducted, reproductive counseling included CD4 cell count and HIV viral load assessment, advising mutual HIV status disclosure, and referral to another provider. Barriers to safer conception counseling included provider assumptions of HIV seroconcordance, low knowledge of safer conception strategies, personal feelings toward PLWH having children, and challenges to tailoring safer sex messages. Conclusions: Providers need information about HIV serodiscordance and safer conception strategies to move beyond discussing only perinatal transmission and maternal health for PLWH who choose to conceive. Safer conception counseling may be more feasible if the message is distilled to delaying conception attempts until the infected partner is on antiretroviral therapy. Designated and motivated nurse providers may be required to provide comprehensive safer conception counseling. PMID:25436820

  18. Care coordination between specialty care and primary care: a focus group study of provider perspectives on strong practices and improvement opportunities.

    PubMed

    Kim, Bo; Lucatorto, Michelle A; Hawthorne, Kara; Hersh, Janis; Myers, Raquel; Elwy, A Rani; Graham, Glenn D

    2015-01-01

    Care coordination between the specialty care provider (SCP) and the primary care provider (PCP) is a critical component of safe, efficient, and patient-centered care. Veterans Health Administration conducted a series of focus groups of providers, from specialty care and primary care clinics at VA Medical Centers nationally, to assess 1) what SCPs and PCPs perceive to be current practices that enable or hinder effective care coordination with one another and 2) how these perceptions differ between the two groups of providers. A qualitative thematic analysis of the gathered data validates previous studies that identify communication as being an important enabler of coordination, and uncovers relationship building between specialty care and primary care (particularly through both formal and informal relationship-building opportunities such as collaborative seminars and shared lunch space, respectively) to be the most notable facilitator of effective communication between the two sides. Results from this study suggest concrete next steps that medical facilities can take to improve care coordination, using as their basis the mutual understanding and respect developed between SCPs and PCPs through relationship-building efforts. PMID:25653538

  19. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320 Section 664.320 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR YOUTH... such funds spent on summer employment opportunities (or any other particular element of the...

  20. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320 Section 664.320 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR YOUTH... such funds spent on summer employment opportunities (or any other particular element of the...

  1. Social Support and Youth Physical Activity: The Role of Provider and Type

    ERIC Educational Resources Information Center

    Beets, Michael W.; Vogel, Randy; Forlaw, Loretta; Pitetti, Kenneth H.; Cardinal, Bradley J.

    2006-01-01

    Objective: To examine provider and type variation in social support (SS) for activity. Methods: Three hundred sixty-three fifth to eighth-grade students completed a questionnaire assessing self-reported activity and social support (SS) from 3 providers: mom, dad, and peers. Important covariates of activity were included in the analysis: age, BMI,…

  2. Provider-initiated HIV testing in rural Haiti: low rate of missed opportunities for diagnosis of HIV in a primary care clinic

    PubMed Central

    Ivers, Louise C; Freedberg, Kenneth A; Mukherjee, Joia S

    2007-01-01

    As HIV treatment is scaled-up in resource-poor settings, the timely identification of persons with HIV infection remains an important challenge. Most people with HIV are unaware of their status, and those who are often present late in the course of their illness. Free-standing voluntary counseling and testing sites often have poor uptake of testing. We aimed to evaluate a 'provider-initiated' HIV testing strategy in a primary care clinic in rural resource-poor Haiti by reviewing the number of visits made to clinic before an HIV test was performed in those who were ultimately found to have HIV infection. In collaboration with the Haitian Ministry of Health, a non-governmental organization (Partners In Health) scaled up HIV care in central Haiti by reinforcing primary care clinics, instituting provider-initiated HIV testing and by providing HIV treatment in the context of primary medical care, free of charge to patients. Among a cohort of people with HIV infection, we assessed retrospectively for delays in or 'missed opportunities' for diagnosis of HIV by the providers in one clinic. Of the first 117 patients diagnosed with HIV in one clinic, 100 (85%) were diagnosed at the first medical encounter. Median delay in diagnosis for the remaining 17 was only 62 days (IQR 19 – 122; range 1 – 272). There was no statistical difference in CD4 cell count between those with and without a delay. 3787 HIV tests were performed in the period reviewed. Provider-initiated testing was associated with high volume uptake of HIV testing and minimal delay between first medical encounter and diagnosis of HIV infection. In scale up of HIV care, provider-initiated HIV testing at primary care clinics can be a successful strategy to identify patients with HIV infection. PMID:18047639

  3. Tablet and Face-to-Face Hybrid Professional Development: Providing Earth Systems Science Educators Authentic Research Opportunities through The GLOBE Program at Purdue University

    NASA Astrophysics Data System (ADS)

    Wegner, K.; Branch, B. D.; Smith, S. C.

    2013-12-01

    The Global Learning and Observations to Benefit the Environment (GLOBE) program is a worldwide hands-on, primary and secondary school-based science and education program (www.globe.gov). GLOBE's vision promotes and supports students, teachers and scientists to collaborate on inquiry-based authentic science investigations of the environment and the Earth system working in close partnership with NASA, NOAA and NSF Earth System Science Projects (ESSP's) in study and research about the dynamics of Earth's environment. GLOBE Partners conduct face-to-face Professional Development in more than 110 countries, providing authentic scientific research experience in five investigation areas: atmosphere, earth as a system, hydrology, land cover, and soil. This presentation will provide a sample for a new framework of Professional Development that was implemented in July 2013 at Purdue University lead by Mr. Steven Smith who has tested GLOBE training materials for future training. The presentation will demonstrate how institutions can provide educators authentic scientific research opportunities through various components, including: - Carrying out authentic research investigations - Learning how to enter their authentic research data into the GLOBE database and visualize it on the GLOBE website - Learn how to access to NASA's Earth System Science resources via GLOBE's new online 'e-Training Program' - Exploring the connections of their soil protocol measurements and the history of the soil in their area through iPad soils app - LIDAR data exposure, Hydrology data exposure

  4. Lost opportunities to identify and treat HIV-positive patients: results from a baseline assessment of provider-initiated HIV testing and counseling (PITC) in Malawi

    PubMed Central

    Ahmed, Saeed; Schwarz, Monica; Flick, Robert; Rees, Chris A.; Harawa, Mwelura; Simon, Katie; Robison, Jeff; Kazembe, Peter N.; Kim, Maria H.

    2016-01-01

    Objective To assess implementation of provider-initiated testing and counseling (PITC) for HIV in Malawi. Methods A review of PITC practices within 118 departments in 12 Ministry of Health (MoH) facilities across Malawi was conducted. Information on PITC practices was collected via a health facility survey. Data describing patient visits and HIV tests were abstracted from routinely collected program data. Results Reported PITC practices were highly variable. Most providers practiced symptom-based PITC. Antenatal clinics and maternity wards reported widespread use of routine opt-out PITC. In 2014, there was approximately 1 HIV test for every 15 clinic visits. HIV status was ascertained in 94.3% (5,293/5,615) of patients at tuberculosis clinics, 92.6% (30,675/33,142) of patients at antenatal clinics, and 49.4% (6,871/13,914) of patients at sexually transmitted infection clinics. Reported challenges to delivering PITC included test kit shortages (71/71 providers), insufficient physical space (58/71), and inadequate number of HIV counselors (32/71) while providers from inpatient units cited the inability to test on weekends. Conclusions Various models of PITC currently exist at MoH facilities in Malawi. Only antenatal and maternity clinics demonstrated high rates of routine opt-out PITC. The low ratio of facility visits to HIV tests suggests missed opportunities for HIV testing. However, the high proportion of patients at TB and antenatal clinics with known HIV status suggests routine PITC is feasible. These results underscore the need to develop clear, standardized PITC policy and protocols, and to address obstacles of limited health commodities, infrastructure, and human resources. PMID:26806378

  5. Financial Opportunities

    SciTech Connect

    2012-01-19

    The Water Power Program focuses on technological development, and deployment of innovative technologies capable of generating electricity from water. The program funds research and development activities through competitive solicitations. Financial opportunities are avaliable here.

  6. A Work Sampling Study of Provider Activities in School-Based Health Centers

    ERIC Educational Resources Information Center

    Mavis, Brian; Pearson, Rachel; Stewart, Gail; Keefe, Carole

    2009-01-01

    Background: The purpose of this study was to describe provider activities in a convenience sample of School-Based Health Centers (SBHCs). The goal was to determine the relative proportion of time that clinic staff engaged in various patient care and non-patient care activities. Methods: All provider staff at 4 urban SBHCs participated in this…

  7. Windows of opportunity for physical activity in the prevention of obesity.

    PubMed

    Street, S J; Wells, J C K; Hills, A P

    2015-10-01

    Tackling increasing rates of obesity is likely to be a defining feature of health care over the next several decades. Adult obesity is a persistent and treatment-resistant problem. Consequently, an emerging theme in the literature is to commence prevention efforts earlier in the developmental time course. This view is based primarily on epidemiological data demonstrating a link between traits manifesting early during development and increased obesity risk in adulthood. Physical activity is a perennial factor in discussions of obesity prevention. However, the optimal timing and type of physical activity interventions to commence remains unclear. Critical developmental windows of plasticity may afford time-limited opportunities to shape body composition across the life course; however, physical activity has not been explicitly considered in these discussions. Although animal models suggest that physical activity commenced earlier in development has differential effects on obesity onset compared to physical activity commenced in adulthood, human research is lacking. In this conceptual review, we consider physical activity during critical developmental periods as a way to mitigate obesity risk later in life.

  8. Steps for Improving Physical Activity Orientation Among Health-care Providers of Older Cardiovascular Patients

    PubMed Central

    2014-01-01

    Attaining appropriate levels of physical activity can have many potential physiological and psychological benefits in older adults with cardiovascular disease. However, these individuals often report low levels of physical activity and high levels of sedentary behavior. Older adults encounter many potential “barriers” to physical activity, but numerous studies have demonstrated the ability to positively influence this important health behavior using well-established behavior change theories and models. The information provided in this review is directed at health-care providers who have the potential to impact physical activity behaviors during regular, often brief, clinical interactions. In addition to providing the latest physical activity recommendations, this update will provide a brief summary of some of the more widely used behavioral skills and strategies for promoting physical activity in older adults with cardiovascular disease. PMID:25396112

  9. 75 FR 67753 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... of 2006 (``Haiti HOPE Act''). This request for comment is being made pursuant to the Paperwork...: Title: Haitian Hemispheric Opportunity through Partnership Encouragement (``Haiti HOPE'') Act of 2006... additional trade benefits to Haiti. This trade program, the Haitian Hemispheric Opportunity...

  10. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

    PubMed

    Warner, Daniel J; Chen, Hongming; Cantin, Louis-David; Kenna, J Gerry; Stahl, Simone; Walker, Clare L; Noeske, Tobias

    2012-12-01

    The human bile salt export pump (BSEP) is a membrane protein expressed on the canalicular plasma membrane domain of hepatocytes, which mediates active transport of unconjugated and conjugated bile salts from liver cells into bile. BSEP activity therefore plays an important role in bile flow. In humans, genetically inherited defects in BSEP expression or activity cause cholestatic liver injury, and many drugs that cause cholestatic drug-induced liver injury (DILI) in humans have been shown to inhibit BSEP activity in vitro and in vivo. These findings suggest that inhibition of BSEP activity by drugs could be one of the mechanisms that initiate human DILI. To gain insight into the chemical features responsible for BSEP inhibition, we have used a recently described in vitro membrane vesicle BSEP inhibition assay to quantify transporter inhibition for a set of 624 compounds. The relationship between BSEP inhibition and molecular physicochemical properties was investigated, and our results show that lipophilicity and molecular size are significantly correlated with BSEP inhibition. This data set was further used to build predictive BSEP classification models through multiple quantitative structure-activity relationship modeling approaches. The highest level of predictive accuracy was provided by a support vector machine model (accuracy = 0.87, κ = 0.74). These analyses highlight the potential value that can be gained by combining computational methods with experimental efforts in early stages of drug discovery projects to minimize the propensity of drug candidates to inhibit BSEP.

  11. 75 FR 9423 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection (CBP), Department of Homeland... requirement concerning the African Growth and Opportunity Act Certificate of Origin (AGOA). This request for...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  12. STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?

    PubMed Central

    Nguyen, Paul M.; Putoczki, Tracy L.

    2015-01-01

    The gastrointestinal tract is lined by a single layer of epithelial cells that secrete mucus toward the lumen, which collectively separates the immune sentinels in the underlying lamina propria from the intestinal microflora to prevent aberrant immune responses. Inflammatory bowel disease (IBD) describes a group of autoimmune diseases that arise from defects in epithelial barrier function and, as a consequence, aberrant production of inflammatory cytokines. Among these, interleukin (IL)-6, IL-11, and IL-22 are elevated in human IBD patients and corresponding mouse models and, through activation of the JAK/STAT3 pathway, can both propagate and ameliorate disease. In particular, cytokine-mediated activation of STAT3 in the epithelial lining cells affords cellular protection, survival, and proliferation, thereby affording therapeutic opportunities for the prevention and treatment of colitis. In this review, we focus on recent insights gained from therapeutic modulation of the activities of IL-6, IL-11, and IL-22 in models of IBD and advocate a cautionary approach with these cytokines to minimize their tumor-promoting activities on neoplastic epithelium. PMID:25760898

  13. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., for eligible students. (b) Conducting outreach activities to recruit priority students (identified in... eligible students. (d) Supporting the development or implementation of rigorous academic curricula, which... providing participating students access to rigorous core academic courses that reflect challenging...

  14. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., for eligible students. (b) Conducting outreach activities to recruit priority students (identified in... eligible students. (d) Supporting the development or implementation of rigorous academic curricula, which... providing participating students access to rigorous core academic courses that reflect challenging...

  15. 30 CFR 550.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false If I conduct ancillary activities, what notices must I provide? 550.208 Section 550.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT... least 30 calendar days before you conduct any G&G exploration or development G&G activity (see §...

  16. 30 CFR 550.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false If I conduct ancillary activities, what notices must I provide? 550.208 Section 550.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT... least 30 calendar days before you conduct any G&G exploration or development G&G activity (see §...

  17. 30 CFR 550.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false If I conduct ancillary activities, what notices must I provide? 550.208 Section 550.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT... least 30 calendar days before you conduct any G&G exploration or development G&G activity (see §...

  18. Providing Education to Child Care Instructors: Matching Children's Learning Activities to Cognitive Development.

    ERIC Educational Resources Information Center

    Desjardins, Margaret M.

    Child care instructors and their aides at the Good Shepherd Day Care Center, Punta Gorda, Florida, were taught skills needed to develop classroom activities matching the cognitive development of 3- and 4-year-old children. Through a program of in-service activity in child growth and development, instruction was provided to enable teachers to more…

  19. 30 CFR 250.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false If I conduct ancillary activities, what notices must I provide? 250.208 Section 250.208 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... notices must I provide? At least 30 calendar days before you conduct any G&G exploration or development...

  20. Pupil's Opportunities to Influence Activities: A Study of Everyday Practice at a Swedish Leisure-Time Centre

    ERIC Educational Resources Information Center

    Haglund, Björn

    2015-01-01

    The focal point of this article is a discussion of pupils' opportunities to make their voices heard and influence the activity in a Swedish leisure-time centre. The study comprises six weeks of ethnographically inspired field work including data from participating observations and walk-and-talk conversations. Two voluntary activities, referred to…

  1. Equality or Equity, Player or Guardian? The Dutch Government and Its Role in Providing Access Opportunities for Government Sponsored International Secondary Education, 1979-2009

    ERIC Educational Resources Information Center

    Prickarts, Boris

    2010-01-01

    This article focuses on the Dutch government's International Baccalaureate (IB) Diploma Programme (DP) Pilot, allowing Dutch pre-university students to take part in the IB DP. Is it likely to create "equal", or rather "equitable", access opportunities for government-sponsored Dutch international secondary schools? The article advances the position…

  2. Situating Ontario's Colleges between the American and European Models for Providing Opportunity for the Attainment of Baccalaureate Degrees in Applied Fields of Study

    ERIC Educational Resources Information Center

    Skolnik, Michael L.

    2016-01-01

    During the last third of the twentieth century, college sectors in many countries took on the role of expanding opportunities for baccalaureate degree attainment in applied fields of study. In many European countries, colleges came to constitute a parallel higher education sector that offered degree programs of an applied nature in contrast to the…

  3. Environmental factors: opportunities and barriers for physical activity, and healthy eating among children and adolescents.

    PubMed

    Huybrechts, I; De Bourdeaudhuij, I; De Henauw, S

    2010-01-01

    While genetic factors play a role in the development of obesity, the dramatic increase of its prevalence in the past years strongly suggests that environmental factors are largely responsible. The wealth and variety of food supply available 24h/day and throughout the year, the change in dietary habits due to time constraints and the change in physical activity due to technological advances all create a 'toxic' environment responsible for obesity and eating habit disorders. This manuscript describes and discusses the results of a systematic review of environmental opportunities & obstacles for physical activity and dietary intake influencing the obesity epidemic among children and adolescents. Although evidence clearly shows the impact of the environment on obesity related lifestyle factors, evidence for effective strategies combating this obesogenic environment is very scarce. Interventions aiming to change environmental factors in order to reduce obesity may include taxes/subsidies encouraging healthy eating or physical activity, extra provision of sporting facilities, efforts to improve safety and accessibility of walking, cycling or play areas or attempting to influence social meanings/values attached to weight, food or physical activity. It is clear that some level of institutionalization of systems that support the desired changes is required to sustain environmental and social changes in the long-term. At last, it is important to note that better-designed and -conducted research on the true importance of the interaction between environmental factors and psychosocial factors, including the micro- and the macro-level, for obesogenic behavioral change is needed to reassure the success of large-scale environmental change interventions.

  4. Using existing programs as vehicles to disseminate knowledge, provide opportunities for scientists to assist educators, and to engage students in using real data

    NASA Astrophysics Data System (ADS)

    Smith, S. C.; Wegner, K.; Branch, B. D.; Miller, B.; Schulze, D. G.

    2013-12-01

    Many national and statewide programs throughout the K-12 science education environment teach students about science in a hands-on format, including programs such as Global Learning and Observations to Benefit the Environment (GLOBE), Project Learning Tree (PLT), Project Wild, Project Wet, and Hoosier River Watch. Partnering with one or more of these well-known programs can provide many benefits to both the scientists involved in disseminating research and the K-12 educators. Scientists potentially benefit by broader dissemination of their research by providing content enrichment for educators. Educators benefit by gaining understanding in content, becoming more confident in teaching the concept, and increasing their enthusiasm in teaching the concepts addressed. This presentation will discuss an innovative framework for professional development that was implemented at Purdue University, Indiana in July 2013. The professional development incorporated GLOBE protocols with iPad app modules and interactive content sessions from faculty and professionals. By collaborating with the GLOBE program and scientists from various content areas, the Department of Earth, Atmospheric, and Planetary Sciences at Purdue University successfully facilitated a content rich learning experience for educators. Such activity is promoted and supported by Purdue University Libraries where activities such as Purdue's GIS Day are efforts of making authentic learning sustainable in the State of Indiana and for national consideration. Using iPads to visualize soil transitions on a field trip. Testing Water quality in the field.

  5. "Because I am Muslim, I cannot wear a swimsuit": Muslim girls negotiate participation opportunities for physical activity.

    PubMed

    Hamzeh, Manal; Oliver, Kimberly L

    2012-06-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 muslim girls (ages 14- 17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self mapping questionnaires, digital photos, private journal entries, and recordings of informal conversations. We discuss (a) how three discursive challenges emerged in veiling-off opportunities for physical activity, and (b) how the girls uncovered alternative ways of being physically active. To promote active life practices with muslim girls, we need to (a) navigate the diversity of young muslims within the intersecting discourses in their lives that potentially challenge their participation in physical activities, and (b) honor young muslims' choices while negotiating their chances of maintaining physical activities.

  6. "Because I am Muslim, I cannot wear a swimsuit": Muslim girls negotiate participation opportunities for physical activity.

    PubMed

    Hamzeh, Manal; Oliver, Kimberly L

    2012-06-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 muslim girls (ages 14- 17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self mapping questionnaires, digital photos, private journal entries, and recordings of informal conversations. We discuss (a) how three discursive challenges emerged in veiling-off opportunities for physical activity, and (b) how the girls uncovered alternative ways of being physically active. To promote active life practices with muslim girls, we need to (a) navigate the diversity of young muslims within the intersecting discourses in their lives that potentially challenge their participation in physical activities, and (b) honor young muslims' choices while negotiating their chances of maintaining physical activities. PMID:22808719

  7. 78 FR 42103 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection, Department of Homeland... accordance with the Paperwork Reduction Act: African Growth and Opportunity Act Certificate of Origin (AGOA... previously published in the Federal Register (78 FR 26650) on May 7, 2013, allowing for a 60-day...

  8. 78 FR 26650 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... Opportunity Act Certificate of Origin AGENCY: U.S. Customs and Border Protection, Department of Homeland... Certificate of Origin (AGOA). This request for comments is being made pursuant to the Paperwork Reduction Act...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  9. School Sports Opportunities Influence Physical Activity in Secondary School and beyond

    ERIC Educational Resources Information Center

    Fuller, Daniel; Sabiston, Catherine; Karp, Igor; Barnett, Tracie; O'Loughlin, Jennifer

    2011-01-01

    Background: The purpose of the present study was to examine whether the availability of intramural or extramural sports in secondary schools is associated with physical activity levels in youth throughout secondary school and at age 20. Methods: Eight hundred and eight adolescents from 10 secondary schools in Montreal, Canada, provided physical…

  10. Hydrodynamic instabilities provide a generic route to spontaneous biomimetic oscillations in chemomechanically active filaments

    PubMed Central

    Laskar, Abhrajit; Singh, Rajeev; Ghose, Somdeb; Jayaraman, Gayathri; Kumar, P. B. Sunil; Adhikari, R.

    2013-01-01

    Non-equilibrium processes which convert chemical energy into mechanical motion enable the motility of organisms. Bundles of inextensible filaments driven by energy transduction of molecular motors form essential components of micron-scale motility engines like cilia and flagella. The mimicry of cilia-like motion in recent experiments on synthetic active filaments supports the idea that generic physical mechanisms may be sufficient to generate such motion. Here we show, theoretically, that the competition between the destabilising effect of hydrodynamic interactions induced by force-free and torque-free chemomechanically active flows, and the stabilising effect of nonlinear elasticity, provides a generic route to spontaneous oscillations in active filaments. These oscillations, reminiscent of prokaryotic and eukaryotic flagellar motion, are obtained without having to invoke structural complexity or biochemical regulation. This minimality implies that biomimetic oscillations, previously observed only in complex bundles of active filaments, can be replicated in simple chains of generic chemomechanically active beads. PMID:23752497

  11. Hydrodynamic instabilities provide a generic route to spontaneous biomimetic oscillations in chemomechanically active filaments

    NASA Astrophysics Data System (ADS)

    Laskar, Abhrajit; Singh, Rajeev; Ghose, Somdeb; Jayaraman, Gayathri; Kumar, P. B. Sunil; Adhikari, R.

    2013-06-01

    Non-equilibrium processes which convert chemical energy into mechanical motion enable the motility of organisms. Bundles of inextensible filaments driven by energy transduction of molecular motors form essential components of micron-scale motility engines like cilia and flagella. The mimicry of cilia-like motion in recent experiments on synthetic active filaments supports the idea that generic physical mechanisms may be sufficient to generate such motion. Here we show, theoretically, that the competition between the destabilising effect of hydrodynamic interactions induced by force-free and torque-free chemomechanically active flows, and the stabilising effect of nonlinear elasticity, provides a generic route to spontaneous oscillations in active filaments. These oscillations, reminiscent of prokaryotic and eukaryotic flagellar motion, are obtained without having to invoke structural complexity or biochemical regulation. This minimality implies that biomimetic oscillations, previously observed only in complex bundles of active filaments, can be replicated in simple chains of generic chemomechanically active beads.

  12. Nutrition and Physical Activity Environments of Home-Based Child Care: What Hispanic Providers Have to Say

    PubMed Central

    Mena, Noereem Z.; Risica, Patricia; Gorham, Gemma; Gans, Kim M.

    2015-01-01

    Abstract Background: It is important to understand the perceptions and beliefs of family child care providers (FCCPs) regarding which factors influence children's physical activity (PA), screen-time (ST), and dietary behaviors in order to develop and implement appropriate obesity prevention interventions. The aim of this qualitative study was to explore the aforementioned perceptions and beliefs of FCCPs in Rhode Island. Methods: Four focus groups (n = 30) were held with FCCPs. Providers were female, Hispanic, and Spanish speaking. Providers were asked about different aspects of feeding, PA, and ST behaviors. Themes were coded using NVivo10 (QSR International Pty Ltd, Doncaster, Victoria, Australia). Content analysis was used to analyze final themes. Results: Providers understood the importance of providing opportunities for healthy eating and PA for the children they cared for, but there was room for improvement, especially with regard to certain feeding and ST practices. Several barriers were evident, including the lack of physical infrastructure for PA, cultural beliefs and practices related to child feeding, and difficulties working with parents to provide consistent messages across environments. Conclusions: Given that FCCPs are aware of the importance of healthy eating and PA, there is a need to address the specific barriers they face, and operationalize some of their knowledge into practical everyday actions. This formative work will inform the development of a culturally relevant, multicomponent intervention for ethnically diverse FCCPs to improve the food and PA environments of their homes, which should, in turn, improve the dietary, PA, and ST behaviors of the 2- to 5-year-old children they care for. PMID:26332455

  13. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 4 2013-07-01 2013-07-01 false What other activities may all GEAR UP projects provide? 694.22 Section 694.22 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION (CONTINUED) GAINING EARLY AWARENESS...

  14. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What activities and services does a project provide? 646.4 Section 646.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT SUPPORT SERVICES PROGRAM General §...

  15. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What activities and services does a project provide? 646.4 Section 646.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION STUDENT SUPPORT SERVICES PROGRAM General §...

  16. Disposal R&D in the Used Fuel Disposition Campaign: A Discussion of Opportunities for Active International Collaboration

    SciTech Connect

    Birkholzer, J.T.

    2011-06-01

    For DOE's Used Fuel Disposition Campaign (UFDC), international collaboration is a beneficial and cost-effective strategy for advancing disposal science with regards to multiple disposal options and different geologic environments. While the United States disposal program focused solely on Yucca Mountain tuff as host rock over the past decades, several international programs have made significant progress in the characterization and performance evaluation of other geologic repository options, most of which are very different from the Yucca Mountain site in design and host rock characteristics. Because Yucca Mountain was so unique (e.g., no backfill, unsaturated densely fractured tuff), areas of direct collaboration with international disposal programs were quite limited during that time. The decision by the U.S. Department of Energy to no longer pursue the disposal of high-level radioactive waste and spent fuel at Yucca Mountain has shifted UFDC's interest to disposal options and geologic environments similar to those being investigated by disposal programs in other nations. Much can be gained by close collaboration with these programs, including access to valuable experience and data collected over recent decades. Such collaboration can help to efficiently achieve UFDC's long-term goals of conducting 'experiments to fill data needs and confirm advanced modeling approaches' (by 2015) and of having a 'robust modeling and experimental basis for evaluation of multiple disposal system options' (by 2020). This report discusses selected opportunities of active international collaboration, with focus on both Natural Barrier System (NBS) and Engineered Barrier System (EBS) aspects and those opportunities that provide access to field data (and respective interpretation/modeling) or allow participation in ongoing field experiments. This discussion serves as a basis for the DOE/NE-53 and UFDC planning process for FY12 and beyond.

  17. Estimation of immunization providers' activities cost, medication cost, and immunization dose errors cost in Iraq.

    PubMed

    Al-lela, Omer Qutaiba B; Bahari, Mohd Baidi; Al-abbassi, Mustafa G; Salih, Muhannad R M; Basher, Amena Y

    2012-06-01

    The immunization status of children is improved by interventions that increase community demand for compulsory and non-compulsory vaccines, one of the most important interventions related to immunization providers. The aim of this study is to evaluate the activities of immunization providers in terms of activities time and cost, to calculate the immunization doses cost, and to determine the immunization dose errors cost. Time-motion and cost analysis study design was used. Five public health clinics in Mosul-Iraq participated in the study. Fifty (50) vaccine doses were required to estimate activities time and cost. Micro-costing method was used; time and cost data were collected for each immunization-related activity performed by the clinic staff. A stopwatch was used to measure the duration of activity interactions between the parents and clinic staff. The immunization service cost was calculated by multiplying the average salary/min by activity time per minute. 528 immunization cards of Iraqi children were scanned to determine the number and the cost of immunization doses errors (extraimmunization doses and invalid doses). The average time for child registration was 6.7 min per each immunization dose, and the physician spent more than 10 min per dose. Nurses needed more than 5 min to complete child vaccination. The total cost of immunization activities was 1.67 US$ per each immunization dose. Measles vaccine (fifth dose) has a lower price (0.42 US$) than all other immunization doses. The cost of a total of 288 invalid doses was 744.55 US$ and the cost of a total of 195 extra immunization doses was 503.85 US$. The time spent on physicians' activities was longer than that spent on registrars' and nurses' activities. Physician total cost was higher than registrar cost and nurse cost. The total immunization cost will increase by about 13.3% owing to dose errors.

  18. "Because I Am Muslim, I Cannot Wear a Swimsuit:" Muslim Girls Negotiate Participation Opportunities for Physical Activity

    ERIC Educational Resources Information Center

    Hamzeh, Manal; Oliver, Kimberly L.

    2012-01-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 Muslim girls (ages 14-17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self-mapping questionnaires, digital photos, private journal entries, and recordings of…

  19. 78 FR 76305 - Opportunity for Co-Sponsorship of the President's Challenge Physical Activity and Fitness Awards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... conferences, speaking at events, and using social media. The co- sponsoring organization shall identify and... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Opportunity for Co-Sponsorship of the President's Challenge Physical Activity and...

  20. ARDUSAT, an Arduino-Based CubeSat Providing Students with the Opportunity to Create their own Satellite Experiment and Collect Real-World Space Data

    NASA Astrophysics Data System (ADS)

    Geeroms, D.; Bertho, S.; De Roeve, M.; Lempens, R.; Ordies, M.; Prooth, J.

    2015-09-01

    Short for “Arduino Satellite”, ArduSat is an open-source Nanosatellite, based on the CubeSat standard. The extensive Arduino sensor suite on board gives students the opportunity to create their own satellite experiments and collect real-world space data using the Arduino open-source prototyping platform. From March until May 2014, two undergraduate physics students from Hasselt University used the downloadable ArduSat Software Development Kit which allowed them to design the command sequences they used to conduct their experiments.

  1. 76 FR 623 - Proposed Information Collection (Equal Opportunity Compliance Review Report) Activity: Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Federal financial assistance comply with the applicable civil rights law and regulations. DATES: Written... approved collection. Abstract: Executive Order 12250, Leadership and Coordination of Nondiscrimination Laws... agencies of various equal opportunity laws prohibiting discriminatory practices in Federal programs...

  2. Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

    PubMed

    Yates, Luke A; Durrant, Benjamin P; Fleurdépine, Sophie; Harlos, Karl; Norbury, Chris J; Gilbert, Robert J C

    2015-03-11

    Terminal uridylyl transferases (TUTs) are responsible for the post-transcriptional addition of uridyl residues to RNA 3' ends, leading in some cases to altered stability. The Schizosaccharomyces pombe TUT Cid1 is a model enzyme that has been characterized structurally at moderate resolution and provides insights into the larger and more complex mammalian TUTs, ZCCHC6 and ZCCHC11. Here, we report a higher resolution (1.74 Å) crystal structure of Cid1 that provides detailed evidence for uracil selection via the dynamic flipping of a single histidine residue. We also describe a novel closed conformation of the enzyme that may represent an intermediate stage in a proposed product ejection mechanism. The structural insights gained, combined with normal mode analysis and biochemical studies, demonstrate that the plasticity of Cid1, particularly about a hinge region (N164-N165), is essential for catalytic activity, and provide an explanation for its distributive uridylyl transferase activity. We propose a model clarifying observed differences between the in vitro apparently processive activity and in vivo distributive monouridylylation activity of Cid1. We suggest that modulating the flexibility of such enzymes-for example by the binding of protein co-factors-may allow them alternatively to add single or multiple uridyl residues to the 3' termini of RNA molecules. PMID:25712096

  3. Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity

    PubMed Central

    Yates, Luke A.; Durrant, Benjamin P.; Fleurdépine, Sophie; Harlos, Karl; Norbury, Chris J.; Gilbert, Robert J.C.

    2015-01-01

    Terminal uridylyl transferases (TUTs) are responsible for the post-transcriptional addition of uridyl residues to RNA 3′ ends, leading in some cases to altered stability. The Schizosaccharomyces pombe TUT Cid1 is a model enzyme that has been characterized structurally at moderate resolution and provides insights into the larger and more complex mammalian TUTs, ZCCHC6 and ZCCHC11. Here, we report a higher resolution (1.74 Å) crystal structure of Cid1 that provides detailed evidence for uracil selection via the dynamic flipping of a single histidine residue. We also describe a novel closed conformation of the enzyme that may represent an intermediate stage in a proposed product ejection mechanism. The structural insights gained, combined with normal mode analysis and biochemical studies, demonstrate that the plasticity of Cid1, particularly about a hinge region (N164–N165), is essential for catalytic activity, and provide an explanation for its distributive uridylyl transferase activity. We propose a model clarifying observed differences between the in vitro apparently processive activity and in vivo distributive monouridylylation activity of Cid1. We suggest that modulating the flexibility of such enzymes—for example by the binding of protein co-factors—may allow them alternatively to add single or multiple uridyl residues to the 3′ termini of RNA molecules. PMID:25712096

  4. Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

    PubMed

    Yates, Luke A; Durrant, Benjamin P; Fleurdépine, Sophie; Harlos, Karl; Norbury, Chris J; Gilbert, Robert J C

    2015-03-11

    Terminal uridylyl transferases (TUTs) are responsible for the post-transcriptional addition of uridyl residues to RNA 3' ends, leading in some cases to altered stability. The Schizosaccharomyces pombe TUT Cid1 is a model enzyme that has been characterized structurally at moderate resolution and provides insights into the larger and more complex mammalian TUTs, ZCCHC6 and ZCCHC11. Here, we report a higher resolution (1.74 Å) crystal structure of Cid1 that provides detailed evidence for uracil selection via the dynamic flipping of a single histidine residue. We also describe a novel closed conformation of the enzyme that may represent an intermediate stage in a proposed product ejection mechanism. The structural insights gained, combined with normal mode analysis and biochemical studies, demonstrate that the plasticity of Cid1, particularly about a hinge region (N164-N165), is essential for catalytic activity, and provide an explanation for its distributive uridylyl transferase activity. We propose a model clarifying observed differences between the in vitro apparently processive activity and in vivo distributive monouridylylation activity of Cid1. We suggest that modulating the flexibility of such enzymes-for example by the binding of protein co-factors-may allow them alternatively to add single or multiple uridyl residues to the 3' termini of RNA molecules.

  5. ERP adaptation provides direct evidence for early mirror neuron activation in the inferior parietal lobule.

    PubMed

    Möhring, Nicole; Brandt, Emily S L; Mohr, Bettina; Pulvermüller, Friedemann; Neuhaus, Andres H

    2014-10-01

    Mirror neuron systems are frequently investigated by assessing overlapping brain activity during observation and execution of actions; however, distinct neuronal subpopulations may be activated that fall below the spatial resolution of magnetic resonance techniques. This shortfall can be resolved using repetition suppression paradigms that identify physiological adaptation processes caused by repeated activation of identical neuronal circuits. Here, event-related potentials were used to investigate the time course of mirror neuron circuit activation using repetition suppression within and across action observation and action execution modalities. In a lip-reading and speech production paradigm, the N170 component indexed stimulus repetition by adapting to both cross-modal and intra-modal repetitions in the left hemisphere. Neuronal source localization revealed activation of the left inferior parietal lobule during cross-modal relative to intra-modal trials. These results provide support for the position that the same neuronal circuits are activated in perceiving and performing articulatory actions. Moreover, our data strongly suggest that inferior parietal lobule mirror neurons are activated relatively early in time, which indicates partly automatic processes of linguistic perception and mirroring. Repetition suppression paradigms therefore help to elucidate neuronal correlates of different cognitive processes and may serve as a starting point for advanced electrophysiological research on mirror neurons.

  6. ERP adaptation provides direct evidence for early mirror neuron activation in the inferior parietal lobule.

    PubMed

    Möhring, Nicole; Brandt, Emily S L; Mohr, Bettina; Pulvermüller, Friedemann; Neuhaus, Andres H

    2014-10-01

    Mirror neuron systems are frequently investigated by assessing overlapping brain activity during observation and execution of actions; however, distinct neuronal subpopulations may be activated that fall below the spatial resolution of magnetic resonance techniques. This shortfall can be resolved using repetition suppression paradigms that identify physiological adaptation processes caused by repeated activation of identical neuronal circuits. Here, event-related potentials were used to investigate the time course of mirror neuron circuit activation using repetition suppression within and across action observation and action execution modalities. In a lip-reading and speech production paradigm, the N170 component indexed stimulus repetition by adapting to both cross-modal and intra-modal repetitions in the left hemisphere. Neuronal source localization revealed activation of the left inferior parietal lobule during cross-modal relative to intra-modal trials. These results provide support for the position that the same neuronal circuits are activated in perceiving and performing articulatory actions. Moreover, our data strongly suggest that inferior parietal lobule mirror neurons are activated relatively early in time, which indicates partly automatic processes of linguistic perception and mirroring. Repetition suppression paradigms therefore help to elucidate neuronal correlates of different cognitive processes and may serve as a starting point for advanced electrophysiological research on mirror neurons. PMID:25017963

  7. The Age of Enlightenment: Evolving Opportunities in Brain Research Through Optical Manipulation of Neuronal Activity

    PubMed Central

    Jerome, Jason; Heck, Detlef H.

    2011-01-01

    Optical manipulation of neuronal activity has rapidly developed into the most powerful and widely used approach to study mechanisms related to neuronal connectivity over a range of scales. Since the early use of single site uncaging to map network connectivity, rapid technological development of light modulation techniques has added important new options, such as fast scanning photostimulation, massively parallel control of light stimuli, holographic uncaging, and two-photon stimulation techniques. Exciting new developments in optogenetics complement neurotransmitter uncaging techniques by providing cell-type specificity and in vivo usability, providing optical access to the neural substrates of behavior. Here we review the rapid evolution of methods for the optical manipulation of neuronal activity, emphasizing crucial recent developments. PMID:22275886

  8. Providing Paid Employment Opportunities for TANF Participants Engaged in Vocational Education Programs: Examples from Denver, Colorado; Kentucky; and California. Strategies for Increasing TANF Work Participation Rates. Brief Number 1

    ERIC Educational Resources Information Center

    Person, Ann; Pavetti, LaDonna; Max, Jeffrey

    2008-01-01

    This practice brief profiles three programs, two statewide and one local, that provide work opportunities to Temporary Assistance for Needy Families (TANF) recipients who are participating in vocational education programs. The authors selected programs that combine vocational education and paid work because this strategy reinforces the emphasis of…

  9. Operational Issues for Further Study in the Implementation of the Policy of the State Board of Education for Providing Equitable Opportunities for an Essential Education for All Students in Nebraska Public School Districts

    ERIC Educational Resources Information Center

    Nebraska State Department of Education, 2004

    2004-01-01

    This "Operational Issues" document is intended to accompany the State Board of Education?s policy recommendations for providing equitable opportunities for all Nebraska students to receive an essential education. The Essential Education Policy will serve as the foundation document to guide immediate and long-range planning to achieve the equitable…

  10. The Active Site of Oligogalacturonate Lyase Provides Unique Insights into Cytoplasmic Oligogalacturonate β-Elimination*

    PubMed Central

    Abbott, D. Wade; Gilbert, Harry J.; Boraston, Alisdair B.

    2010-01-01

    Oligogalacturonate lyases (OGLs; now also classified as pectate lyase family 22) are cytoplasmic enzymes found in pectinolytic members of Enterobacteriaceae, such as the enteropathogen Yersinia enterocolitica. OGLs utilize a β-elimination mechanism to preferentially catalyze the conversion of saturated and unsaturated digalacturonate into monogalacturonate and the 4,5-unsaturated monogalacturonate-like molecule, 5-keto-4-deoxyuronate. To provide mechanistic insights into the specificity of this enzyme activity, we have characterized the OGL from Y. enterocolitica, YeOGL, on oligogalacturonides and determined its three-dimensional x-ray structure to 1.65 Å. The model contains a Mn2+ atom in the active site, which is coordinated by three histidines, one glutamine, and an acetate ion. The acetate mimics the binding of the uronate group of galactourono-configured substrates. These findings, in combination with enzyme kinetics and metal supplementation assays, provide a framework for modeling the active site architecture of OGL. This enzyme appears to contain a histidine for the abstraction of the α-proton in the −1 subsite, a residue that is highly conserved throughout the OGL family and represents a unique catalytic base among pectic active lyases. In addition, we present a hypothesis for an emerging relationship observed between the cellular distribution of pectate lyase folding and the distinct metal coordination chemistries of pectate lyases. PMID:20851883

  11. Use of measles supplemental immunization activities (SIAs) as a delivery platform for other maternal and child health interventions: opportunities and challenges.

    PubMed

    Johri, Mira; Sharma, Jitendar K; Jit, Mark; Verguet, Stéphane

    2013-02-18

    Measles supplementary immunization activities (SIAs) offer children in countries with weaker immunization delivery systems like India a second opportunity for measles vaccination. They could also provide a platform to deliver additional interventions, but the feasibility and acceptability of including add-ons is uncertain. We surveyed Indian programme officers involved in the current (2010-2012) measles SIAs concerning opportunities and challenges of using SIAs as a delivery platform for other maternal and child health interventions. Respondents felt that an expanded SIA strategy including add-ons could be of great value in improving access and efficiency. They viewed management challenges, logistics, and safety as the most important potential barriers. They proposed that additional interventions be selected using several criteria, of which importance of the health problem, safety, and contribution to health equity figured most prominently. For children, they recommended inclusion of basic interventions to address nutritional deficiencies, diarrhoea and parasites over vaccines. For mothers, micronutrient interventions were highest ranked.

  12. Application of activity-based costing (ABC) for a Peruvian NGO healthcare provider.

    PubMed

    Waters, H; Abdallah, H; Santillán, D

    2001-01-01

    This article describes the application of activity-based costing (ABC) to calculate the unit costs of the services for a health care provider in Peru. While traditional costing allocates overhead and indirect costs in proportion to production volume or to direct costs, ABC assigns costs through activities within an organization. ABC uses personnel interviews to determine principal activities and the distribution of individual's time among these activities. Indirect costs are linked to services through time allocation and other tracing methods, and the result is a more accurate estimate of unit costs. The study concludes that applying ABC in a developing country setting is feasible, yielding results that are directly applicable to pricing and management. ABC determines costs for individual clinics, departments and services according to the activities that originate these costs, showing where an organization spends its money. With this information, it is possible to identify services that are generating extra revenue and those operating at a loss, and to calculate cross subsidies across services. ABC also highlights areas in the health care process where efficiency improvements are possible. Conclusions about the ultimate impact of the methodology are not drawn here, since the study was not repeated and changes in utilization patterns and the addition of new clinics affected applicability of the results. A potential constraint to implementing ABC is the availability and organization of cost information. Applying ABC efficiently requires information to be readily available, by cost category and department, since the greatest benefits of ABC come from frequent, systematic application of the methodology in order to monitor efficiency and provide feedback for management. The article concludes with a discussion of the potential applications of ABC in the health sector in developing countries. PMID:11326572

  13. Application of activity-based costing (ABC) for a Peruvian NGO healthcare provider.

    PubMed

    Waters, H; Abdallah, H; Santillán, D

    2001-01-01

    This article describes the application of activity-based costing (ABC) to calculate the unit costs of the services for a health care provider in Peru. While traditional costing allocates overhead and indirect costs in proportion to production volume or to direct costs, ABC assigns costs through activities within an organization. ABC uses personnel interviews to determine principal activities and the distribution of individual's time among these activities. Indirect costs are linked to services through time allocation and other tracing methods, and the result is a more accurate estimate of unit costs. The study concludes that applying ABC in a developing country setting is feasible, yielding results that are directly applicable to pricing and management. ABC determines costs for individual clinics, departments and services according to the activities that originate these costs, showing where an organization spends its money. With this information, it is possible to identify services that are generating extra revenue and those operating at a loss, and to calculate cross subsidies across services. ABC also highlights areas in the health care process where efficiency improvements are possible. Conclusions about the ultimate impact of the methodology are not drawn here, since the study was not repeated and changes in utilization patterns and the addition of new clinics affected applicability of the results. A potential constraint to implementing ABC is the availability and organization of cost information. Applying ABC efficiently requires information to be readily available, by cost category and department, since the greatest benefits of ABC come from frequent, systematic application of the methodology in order to monitor efficiency and provide feedback for management. The article concludes with a discussion of the potential applications of ABC in the health sector in developing countries.

  14. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans.

    PubMed

    Evans, Erica K; Tester, Richland; Aslanian, Sharon; Karp, Russell; Sheets, Michael; Labenski, Matthew T; Witowski, Steven R; Lounsbury, Heather; Chaturvedi, Prasoon; Mazdiyasni, Hormoz; Zhu, Zhendong; Nacht, Mariana; Freed, Martin I; Petter, Russell C; Dubrovskiy, Alex; Singh, Juswinder; Westlin, William F

    2013-08-01

    Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as promising agents in autoimmune disease and B cell malignancies. Bruton's tyrosine kinase (Btk) plays a crucial role in B cell development and activation through the BCR signaling pathway and represents a new target for diseases characterized by inappropriate B cell activity. N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide (CC-292) is a highly selective, covalent Btk inhibitor and a sensitive and quantitative assay that measures CC-292-Btk engagement has been developed. This translational pharmacodynamic assay has accompanied CC-292 through each step of drug discovery and development. These studies demonstrate the quantity of Btk bound by CC-292 correlates with the efficacy of CC-292 in vitro and in the collagen-induced arthritis model of autoimmune disease. Recently, CC-292 has entered human clinical trials with a trial design that has provided rapid insight into safety, pharmacokinetics, and pharmacodynamics. This first-in-human healthy volunteer trial has demonstrated that a single oral dose of 2 mg/kg CC-292 consistently engaged all circulating Btk protein and provides the basis for rational dose selection in future clinical trials. This targeted covalent drug design approach has enabled the discovery and early clinical development of CC-292 and has provided support for Btk as a valuable drug target for B-cell mediated disorders.

  15. Assessing Challenges and Opportunities for Education and Communication Activities for International Polar Year 2007-2008

    NASA Astrophysics Data System (ADS)

    McCaffrey, M. S.

    2005-05-01

    Considerable planning has gone into identifying ways to maximize International Polar Year 2007-2008 (IPY) as a global event that will facilitate the integration of research and education inherent in IPY, and draw the interest and involvement of people around the world. Documents developed through the IPY planning process, including NRC Reports (2004), and drafts reports on education and outreach from the ICSU IPY Planning Group in the Fall of 2004, and the Bridging the Poles workshop of June, 2004, articulate the tremendous potential for IPY beyond the formal research agenda and goals. With less that two years before the start of IPY and fewer than fours years before the activities are completed, these and emerging opportunities face a number of challenges. In addition to the limited time frame remaining to prepare for these activities, participants involved with IPY education and outreach will also need to consider factors such as: uncertain funding for such activities; the lack of established international networks for geoscience education; the need for high level coordination of IPY education and communication; and the creative and intellectual challenge of making the polar regions relevant to people around the world. The planning process has identified six constituencies as key audiences of IPY communication efforts: i) the scientific/research community, ii) young and potentially new polar researchers, iii) the pre-university education community, iv) arctic communities, iv) the general public, and v) decision-makers. Understanding and meeting these audiences' expectations through on-going evaluation and engagement will be key to successful IPY education and outreach efforts. A number of distinct education and outreach projects have been proposed to the ICSU-WMO IPY planning process, such as courses and workshops on specific aspects of IPY, including efforts to address the social and cultural dimension of Arctic peoples. To help meet the challenges, achieve the

  16. The Fidelity Index provides a systematic quantitation of star activity of DNA restriction endonucleases

    PubMed Central

    Wei, Hua; Therrien, Caitlin; Blanchard, Aine; Guan, Shengxi; Zhu, Zhenyu

    2008-01-01

    Restriction endonucleases are the basic tools of molecular biology. Many restriction endonucleases show relaxed sequence recognition, called star activity, as an inherent property under various digestion conditions including the optimal ones. To quantify this property we propose the concept of the Fidelity Index (FI), which is defined as the ratio of the maximum enzyme amount showing no star activity to the minimum amount needed for complete digestion at the cognate recognition site for any particular restriction endonuclease. Fidelity indices for a large number of restriction endonucleases are reported here. The effects of reaction vessel, reaction volume, incubation mode, substrate differences, reaction time, reaction temperature and additional glycerol, DMSO, ethanol and Mn2+ on the FI are also investigated. The FI provides a practical guideline for the use of restriction endonucleases and defines a fundamental property by which restriction endonucleases can be characterized. PMID:18413342

  17. 78 FR 76851 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...As part of its continuing effort to reduce paperwork and respondent burden, CBP invites the general public and other Federal agencies to comment on an information collection requirement concerning the Haitian Hemispheric Opportunity through Partnership Encouragement Act of 2006 (``Haiti HOPE Act''). This request for comment is being made pursuant to the Paperwork Reduction Act of 1995 (Pub. L.......

  18. 76 FR 164 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... published in the Federal Register (75 FR 67753) on November 3, 2010, allowing for a 60-day comment period... Management and Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act: Haiti Haitian Hemispheric Opportunity through Partnership Encouragement (``Haiti HOPE'') Act of 2006. This is...

  19. Caution: business opportunity ahead.

    PubMed

    Costello, M M

    1986-01-01

    Increasing competition in the market for health care services has led many providers to contemplate activities that would not have received consideration a decade ago. Entrepreneurial in nature, these endeavors require a form of business analysis with which many health care administrators are unfamiliar. Evaluation of health care business opportunities should include consideration of market perspective, relative difficulty of implementation and execution, likely response of competition, and unique aspects of the entrepreneurial personality when found in traditional health care organizations.

  20. Technology solutions to support supervisory activities and also to provide information access to the society

    NASA Astrophysics Data System (ADS)

    Paladini, D.; Mello, A. B.

    2016-07-01

    Inmetro's data about the conformity of certificated products, process and services are, usually, displayed at fragmented databases of difficult access for several reasons, for instance, the lack of computational solutions which allow this kind of access to its users. A discussion about some of the technological solutions to support supervisory activities by the appropriate regulatory bodies and also to provide information access to society in general is herein presented, along with a theoretical explanation of the pros and cons of such technologies to the conclusion that a mobile platform seems to be the best tool for the requirements of Inmetro.

  1. Emergency department syndromic surveillance providing early warning of seasonal respiratory activity in England.

    PubMed

    Hughes, H E; Morbey, R; Hughes, T C; Locker, T E; Pebody, R; Green, H K; Ellis, J; Smith, G E; Elliot, A J

    2016-04-01

    Seasonal respiratory infections place an increased burden on health services annually. We used a sentinel emergency department syndromic surveillance system to understand the factors driving respiratory attendances at emergency departments (EDs) in England. Trends in different respiratory indicators were observed to peak at different points during winter, with further variation observed in the distribution of attendances by age. Multiple linear regression analysis revealed acute respiratory infection and bronchitis/bronchiolitis ED attendances in patients aged 1-4 years were particularly sensitive indicators for increasing respiratory syncytial virus activity. Using near real-time surveillance of respiratory ED attendances may provide early warning of increased winter pressures in EDs, particularly driven by seasonal pathogens. This surveillance may provide additional intelligence about different categories of attendance, highlighting pressures in particular age groups, thereby aiding planning and preparation to respond to acute changes in EDs, and thus the health service in general.

  2. Multitargeting of selected prostanoid receptors provides agents with enhanced anti-inflammatory activity in macrophages.

    PubMed

    Wang, Jenny W; Woodward, David F; Martos, Jose L; Cornell, Clive L; Carling, Robert W; Kingsley, Philip J; Marnett, Lawrence J

    2016-01-01

    A polypharmacologic approach to prostanoid based anti-inflammatory therapeutics was undertaken in order to exploit both the anti- and proinflammatory properties attributed to the various prostanoid receptors. Multitargeting of selected prostanoid receptors yielded a prototype compound, compound 1 (AGN 211377), that antagonizes prostaglandin D2 receptors (DPs) DP1 (49) and DP2 (558), prostaglandin E2 receptors (EPs) EP1 (266) and EP4 (117), prostaglandin F2α receptor (FP) (61), and thromboxane A2 receptor (TP) (11) while sparing EP2, EP3, and prostaglandin I2 receptors (IPs); Kb values (in nanomoles) are given in parentheses. Compound 1 evoked a pronounced inhibition of cytokine/chemokine secretion from lipopolysaccharide or TNF-α stimulated primary human macrophages. These cytokine/chemokines included cluster of designation 40 receptor (CD40), epithelial-derived neutrophil-activating protein 78 (ENA-78), granulocyte colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF), IL-8, IL-18, monocyte chemotactic protein-1 (CCL2) (MCP-1), tissue plasminogen activator inhibitor (PAI-1), and regulated on activation, normal T cell expressed and secreted (RANTES). In contrast, the inhibitory effects of most antagonists selective for a single receptor were modest or absent, and selective EP2 receptor blockade increased cytokine release in some instances. Compound 1 also showed clear superiority to the cyclooxygenase inhibitors diclofenac and rofecoxib. These findings reveal that blockade of multiple prostanoid receptors, with absent antagonism of EP2 and IP, may provide more effective anti-inflammatory activity than global suppression of prostanoid synthesis or highly selective prostanoid receptor blockade. These investigations demonstrate the first working example of prostanoid receptor polypharmacology for potentially safer and more effective anti-inflammatory therapeutics by blocking multiple proinflammatory receptors while sparing

  3. Hydrogen Infrastructure Market Readiness: Opportunities and Potential for Near-term Cost Reductions; Proceedings of the Hydrogen Infrastructure Market Readiness Workshop and Summary of Feedback Provided through the Hydrogen Station Cost Calculator

    SciTech Connect

    Melaina, M. W.; Steward, D.; Penev, M.; McQueen, S.; Jaffe, S.; Talon, C.

    2012-08-01

    Recent progress with fuel cell electric vehicles (FCEVs) has focused attention on hydrogen infrastructure as a critical commercialization barrier. With major automakers focused on 2015 as a target timeframe for global FCEV commercialization, the window of opportunity is short for establishing a sufficient network of hydrogen stations to support large-volume vehicle deployments. This report describes expert feedback on the market readiness of hydrogen infrastructure technology from two activities.

  4. Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations

    SciTech Connect

    Spraggon, Glen; Hornsby, Michael; Shipway, Aaron; Tully, David C.; Bursulaya, Badry; Danahay, Henry; Harris, Jennifer L.; Lesley, Scott A.

    2010-01-12

    Prostasin or human channel-activating protease 1 has been reported to play a critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel. Here, the structure of the extracellular portion of the membrane associated serine protease has been solved to high resolution in complex with a nonselective d-FFR chloromethyl ketone inhibitor, in an apo form, in a form where the apo crystal has been soaked with the covalent inhibitor camostat and in complex with the protein inhibitor aprotinin. It was also crystallized in the presence of the divalent cation Ca{sup +2}. Comparison of the structures with each other and with other members of the trypsin-like serine protease family reveals unique structural features of prostasin and a large degree of conformational variation within specificity determining loops. Of particular interest is the S1 subsite loop which opens and closes in response to basic residues or divalent ions, directly binding Ca{sup +2} cations. This induced fit active site provides a new possible mode of regulation of trypsin-like proteases adapted in particular to extracellular regions with variable ionic concentrations such as the outer membrane layer of the epithelial cell.

  5. Study provides data on active plate tectonics in southeast Asia region

    NASA Astrophysics Data System (ADS)

    Wilson, P.; Rais, J.; Reigber, Ch.; Reinhart, E.; Ambrosius, B. A. C.; Le Pichon, X.; Kasser, M.; Suharto, P.; Majid, Dato'Abdul; Yaakub, Dato'Paduka Awang Haji Othman Bin Haji; Almeda, R.; Boonphakdee, C.

    A major geodynamic study has provided significant new information about the location of active plate boundaries in and around Southeast Asia, as well as deformation processes in the Sulawesi region of Indonesia and tectonic activity in the Philippine archipelago. Results also have confirmed the existence of the so-called Sunda Block, which appears to be rotating with respect to adjacent plates.The study, known as the Geodynamics of South and South-East Asia (GEODYSSEA) project, has been a joint venture of the European Commission and the Association of South- East Asian Nations. It began in 1991 and involved a large team of European and Asian scientists and technicians studying the complex geodynamic processes and natural hazards of the region from the Southeast Asia mainland to the Philippines to northern Australia. Earthquakes, volcanic eruptions, tsunamis, and tectonically induced landslides endanger the lives of millions of people in the region, and the tectonic activity behind these natural hazards results from the convergence and collision of the Eurasian, Philippine, and Indo-Australian Plates at relative velocities of up to 10 cm per year.

  6. Engineered Nanostructures of Antigen Provide an Effective Means for Regulating Mast Cell Activation

    PubMed Central

    Deng, Zhao; Weng, I-Chun; Li, Jie-Ren; Chen, Huan-Yuan; Liu, Fu-Tong; Liu, Gang-yu

    2011-01-01

    Nanostructures containing 2,4-Dinitrophenyl (DNP) as antigen were designed and produced to investigate antibody-mediated activation of mast cells. The design consists of nanogrids of DNP termini inlaid in alkanethiol self-assembled monolayers (SAMs). Using scanning probe-based nanografting, nanometer precision was attained for designed geometry, size and periodicity. Rat basophilic leukemia (RBL) cells exhibited high sensitivity to the geometry and local environment of DNP presented on these nanostructures. The impact included cellular adherence, spreading, membrane morphology, cytoskeleton structure, and activation. The highest level of spreading and activation was induced by nanogrids of 17 nm line width and 40 nm periodicity, with DNP haptens 1.4 nm above the surroundings. The high efficacy is attributed to two main factors. First, DNP sites in the nanostructure are highly accessible by anti-DNP-IgE during recognition. Second, the arrangement or geometry of DNP termini in nanostructures promotes clustering of FcεRI receptors that are pre-linked to IgE. The clustering effectively initiates Lyn-mediated signaling cascades, ultimately leading to the degranulation of RBL cells. This work demonstrates an important concept, that nanostructures of ligands provide new and effective cues for directing cellular signaling processes. PMID:21999491

  7. Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach.

    PubMed

    Hashitani, Hikaru; Garcia-Londoño, A Pilar; Hirst, G David S; Edwards, Frank R

    2005-12-01

    When intracellular recordings were made from the circular layer of the intact muscular wall of the isolated guinea pig gastric corpus, an ongoing regular high frequency discharge of slow waves was detected even though this region lacked myenteric interstitial cells. When slow waves were recorded from preparations consisting of both the antrum and the corpus, slow waves of identical frequency, but with different shapes, were generated in the two regions. Corporal slow waves could be distinguished from antral slow waves by their time courses and amplitudes. Corporal slow waves, like antral slow waves, were abolished by buffering the internal concentration of calcium ions, [Ca2+]i, to low levels, or by caffeine, 2-aminoethoxydiphenyl borate or the chloride channel blocker DIDS. Corporal preparations demonstrated an ongoing discharge of unitary potentials, as has been found in all other tissues containing interstitial cells. The experiments show that the corpus provides the dominant pacemaker activity which entrains activity in other regions of the stomach and it is suggested that this activity is generated by corporal intramuscular interstitial cells.

  8. Motivational Interviewing among HIV Health Care Providers: Challenges and Opportunities to Enhance Engagement and Retention in Care in Buenos Aires, Argentina.

    PubMed

    Bofill, Lina; Weiss, Stephen M; Lucas, Mar; Bordato, Alejandra; Dorigo, Analia; Fernandez-Cabanillas, Graciela; Aristegui, Ines; Lopez, Maria; Waldrop-Valverde, Drenna; Jones, Deborah

    2015-01-01

    In Argentina, providers' response to motivational interviewing (MI) to improve engagement and retention in care among challenging patients with HIV was evaluated. Twelve HIV care physicians participated, and their video recordings pre- and post-MI training were also obtained. One week post-training, 11 of the 12 participants were committed to using MI strategies during consult session. Of the 12 participants, 9 demonstrated appropriate utilization of MI techniques and change in HIV education provided during consultation (Z = -2.375, P = .018). Motivational interviewing appears to be a viable strategy to enhance engagement and retention in challenging HIV-positive patients.

  9. Long-term care and health information technology: opportunities and responsibilities for long-term and post-acute care providers.

    PubMed

    MacTaggart, Patricia; Thorpe, Jane Hyatt

    2013-01-01

    Long-term and post-acute care providers (LTPAC) need to understand the multiple aspects of health information technology (HIT) in the context of health systems transformation in order to be a viable participant. The issues with moving to HIT are not just technical and funding, but include legal and policy, technical and business operations, and very significantly, governance. There are many unanswered questions. However, changes in payment methodologies, service delivery models, consumer expectations, and regulatory requirements necessitate that LTPAC providers begin their journey. PMID:24159273

  10. Monte Carlo modeling provides accurate calibration factors for radionuclide activity meters.

    PubMed

    Zagni, F; Cicoria, G; Lucconi, G; Infantino, A; Lodi, F; Marengo, M

    2014-12-01

    Accurate determination of calibration factors for radionuclide activity meters is crucial for quantitative studies and in the optimization step of radiation protection, as these detectors are widespread in radiopharmacy and nuclear medicine facilities. In this work we developed the Monte Carlo model of a widely used activity meter, using the Geant4 simulation toolkit. More precisely the "PENELOPE" EM physics models were employed. The model was validated by means of several certified sources, traceable to primary activity standards, and other sources locally standardized with spectrometry measurements, plus other experimental tests. Great care was taken in order to accurately reproduce the geometrical details of the gas chamber and the activity sources, each of which is different in shape and enclosed in a unique container. Both relative calibration factors and ionization current obtained with simulations were compared against experimental measurements; further tests were carried out, such as the comparison of the relative response of the chamber for a source placed at different positions. The results showed a satisfactory level of accuracy in the energy range of interest, with the discrepancies lower than 4% for all the tested parameters. This shows that an accurate Monte Carlo modeling of this type of detector is feasible using the low-energy physics models embedded in Geant4. The obtained Monte Carlo model establishes a powerful tool for first instance determination of new calibration factors for non-standard radionuclides, for custom containers, when a reference source is not available. Moreover, the model provides an experimental setup for further research and optimization with regards to materials and geometrical details of the measuring setup, such as the ionization chamber itself or the containers configuration.

  11. Improving Educational Opportunities for Low-Income Children. Hearing on Examining Proposals to Improve Educational Opportunities for Low-Income Children, Including Provisions of S. 847, to Provide Scholarship Assistance for District of Columbia Elementary and Secondary School Students, Hearing of the Committee on Labor and Human Resources. United States Senate, One Hundred Fifth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on Labor and Human Resources.

    The Senate Committee on Labor and Human Resources met to hear two panels of witnesses discuss improving educational opportunities for low-income children, including provisions of Senate 847, to provide scholarship assistance for District of Columbia elementary and secondary school students. Opening remarks by Senators Coats, Lieberman, Reed, and…

  12. Dynamic Response of the Environment at the Moon (DREAM): Providing Opportunities for Students and Teachers to Learn About the Solar-lunar Environmental Connection

    NASA Astrophysics Data System (ADS)

    Bleacher, L.; Weir, H. M.; Twu, Y.; Farrell, W. M.; Gross, N. A.

    2009-12-01

    The Dynamic Response of the Environment at the Moon (DREAM) team is one of seven teams comprising the NASA Lunar Science Institute. DREAM’s goal is to reveal, advance, and test the extremes of the solar-lunar environmental connection. DREAM’s education and outreach (E/PO) program is focused on student and teacher participation with scientists. The primary component of the DREAM E/PO program is two Lunar Extreme Workshops (LEWs) and the supporting materials developed for each LEW. The workshops will bring together scientists and modelers from the DREAM team with advanced high school and/or community college students and their teachers. The LEWs will allow student/teacher participants to interact directly with the scientists and to experience the process of science in action. Participation in LEWs and pre-LEW training will expose students to science, technology, engineering, and math (STEM) careers and engage them in learning new STEM content. During the two LEWs, the new, integrated lunar models developed by the DREAM team will be tested using extreme environmental drivers. These extreme events include: 1) solar storms and human excursion into Shackleton Crater and 2) human activity/lunar excavation and impact cratering. Although the LEWs will be complex in nature, the students and teachers will receive extensive pre-LEW training via access to online curricular resources already in development and Webinars with DREAM science team members, during which the students/teachers will get to know the team members and put their new knowledge into context. The curricular materials will include resources and activities pertaining to space weather, plasma, electricity, circuits, magnetism, magnetospheres, exospheres, impact cratering, and modeling. The activities are being mapped to the National Science Education Standards and the American Association for the Advancement of Science’s Benchmarks for Science Literacy. Students will be encouraged to read and review

  13. Biomedical health assessments of the Florida manatee in Crystal River - providing opportunities for training during the capture, handling, and processing of this endangered aquatic mammal

    USGS Publications Warehouse

    Bonde, Robert K.; Garrett, Andrew; Belanger, Michael; Askin, Nesime; Tan, Luke; Wittnich, Carin

    2012-01-01

    Federal and state researchers have been involved in manatee (Trichechus manatus) biomedical health assessment programs for a couple of decades. These benchmark studies have provided a foundation for the development of consistent capture, handling, and processing techniques and protocols. Biologists have implemented training and encouraged multi-agency participation whenever possible to ensure reliable data acquisition, recording, sample collection, publication integrity, and meeting rigorous archival standards. Under a U.S. Fish and Wildlife Service wildlife research permit granted to the U.S. Geological Survey (USGS) Sirenia Project, federal biologists and collaborators are allowed to conduct research studies on wild and captive manatees detailing various aspects of their biology. Therefore, researchers with the project have been collaborating on numerous studies over the last several years. One extensive study, initiated in 2006 has focused on health and fitness of the winter manatee population located in Crystal River, Florida. During those health assessments, capture, handling, and work-up training has been afforded to many of the participants. That study has successfully captured and handled 123 manatees. The data gathered have provided baseline information on manatee health, reproductive status, and nutritional condition. This research initiative addresses concerns and priorities outlined in the Florida Manatee Recovery Plan. The assessment teams strive to continue this collaborative effort to help advance our understanding of health-related issues confronting manatees throughout their range and interlacing these findings with surrogate species concepts.

  14. Opportunity fuels

    SciTech Connect

    Lutwen, R.C.

    1996-12-31

    The paper consists of viewgraphs from a conference presentation. A comparison is made of opportunity fuels, defined as fuels that can be converted to other forms of energy at lower cost than standard fossil fuels. Types of fuels for which some limited technical data is provided include petroleum coke, garbage, wood waste, and tires. Power plant economics and pollution concerns are listed for each fuel, and compared to coal and natural gas power plant costs. A detailed cost breakdown for different plant types is provided for use in base fuel pricing.

  15. Providing farmers, ranchers, and foresters in California with actionable climate information: opportunities and obstacles for California's USDA Regional Climate Sub Hub

    NASA Astrophysics Data System (ADS)

    Kerr, A. C.; Steenwerth, K. L.; Stine, P.; Chambers, J.; Fischer, C.; Kiger, L.; Hedt, T.; Gonzales, O.; Tse, R.; Tse, A.; Gunasekara, A.; Henly, R.; DeLaRosa, J.; Battany, M.; Pathak, T.; Parker, D.; Schwartz, M.; Tjeerdema, R.; Kalansky, J.; Kehmeier, E.; Xides, A.; Marshall, A.; Jagannathan, K.

    2015-12-01

    California is the #1 agricultural state in the US, with output worth $50 billion in 2014. California produces half the nation's specialty crops (fruits, vegetables, and nuts) and is a leader in beef and dairy production. California also has 10% of the forestland west of the Mississippi, including many economically and ecologically important forest types. The USDA Regional Climate Sub Hub for California was created in 2014 to help land users (farmers, ranchers, and forest land owners) cope with climate variability and change, via two-way linkages with producers of climate information. In its first year and a half, the Sub Hub has formed partnerships with California's many other climate-focused organizations, including state and federal government, universities, and NGOs. The Sub Hub coordinates climate-related work among several USDA agencies (ARS, FS, NRCS, and others), which formerly had no mechanism to do so. The Sub Hub also works with other federal climate programs (such as the DOI's CA Landscape Conservation Cooperative, with which the Sub Hub is engaged in a multi-year assessment to balance conservation and agriculture in the Central Valley). State government agencies, such as the Natural Resources Agency and the Department of Food and Agriculture, are key partners for priority-setting and data-sharing. One of the Sub Hub's crucial synergies is with UC Cooperative Extension, which provides insight into land users' needs and provides an outlet to deliver Sub Hub products on the ground. In response to stakeholder concerns, the Sub Hub's 2015-16 emphasis is the ongoing California drought. The Sub Hub's current stakeholder-focused projects include (1) a climate vulnerability assessment of California rangelands, including detailed maps of likely vegetation change and suggestions for location-specific adaptation options; (2) a comprehensive climate-related update of Cooperative Extension's widely used Forest Stewardship Series for private landowners; (3) a study on

  16. LM-research opportunities and activities at the Latvian Academy of Sciences

    SciTech Connect

    Lielausis, O.

    1996-06-01

    In this presentation selected examples will be considered characterizing the breadth of their interests in LM applications. So, InGaSn eutectic was used as a modeling liquid for investigation of MHD effects typical to some LM-blanket configurations. LM coatings proposed for the protection of divertor plates were considered too. Experiments were performed on a superconducting magnet providing a 5.6 T magnetic field in a 30 liters bore. In a large vacuum chamber (12 m{sup 3}; 6.65 10{sup {minus}4} Pa) lithium cooling system for high temperature reactors was examined. Electromagnetic pumps and flowmeters able to work at lithium temperatures up to 960{degrees}C were tested. A Na loop, where two mounted in line electromagnetic pumps are delivering a 25 atm. pressure. The main Na loop equipped with em. pumps is based on a d=10 cm tubing. LM devices were installed in the Latvian 500 MW nuclear research reactor IRT-5000 too. First, a equipped with conductive e.m. pumps loop, where InGaSn serves as a {gamma}-carrier from activity generator (placed close to the core) to two outer 20 Mrad/h irradiators. Second, a LM system for rector control, where contained in InGaSn indium is used for neutron absorption and reactivity control. A closed cylindrical LM container was installed in the core instead of a traditional control rod. The container is divided in two chambers by means of elastic membranes. The one chamber contains InGaSn, the second GaSn (without In). By means of e.m. pumps the proportion between InGaSn and GaSn in the active zone can be changed ensuring a possibility to control the amount of introduced in the core absorbing material. Long term tests of the system were performed on a zero-power assembly. But for a shorter time the system was inserted in the core of the acting main reactor too and the efficiency of the control was confirmed.

  17. Review of international geothermal activities and assessment of US industry opportunities: Summary report

    SciTech Connect

    Not Available

    1987-08-01

    This report summarizes a study initiated to review and assess international developments in the geothermal energy field and to define business opportunities for the US geothermal industry. The report establishes data bases on the status of worldwide geothermal development and the competitiveness of US industry. Other factors identified include existing legislation, tax incentives, and government institutions or agencies and private sector organizations that promote geothermal exports. Based on the initial search of 177 countries and geographic entities, 71 countries and areas were selected as the most likely targets for the expansion of the geothermal industry internationally. The study then determined to what extent their geothermal resource had been developed, what countries had aided or participated in this development, and what plans existed for future development. Data on the energy, economic, and financial situations were gathered.

  18. Review of international geothermal activities and assessment of US industry opportunities: Final report

    SciTech Connect

    Not Available

    1987-08-01

    This study was initiated to review and assess international developments in the geothermal energy field and to define business opportunities for the US geothermal industry. The report establishes data bases on the status of worldwide geothermal development and the competitiveness of US industry. Other factors identified include existing legislation, tax incentives, and government institutions or agencies and private sector organizations that promote geothermal exports. Based on the initial search of 177 countries and geographic entities, 71 countries and areas were selected as the most likely targets for the expansion of the geothermal industry internationally. The study then determined to what extent their geothermal resource had been developed, what countries had aided or participated in this development, and what plans existed for future development. Data on the energy, economic, and financial situations were gathered.

  19. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  20. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  1. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  2. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  3. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... SERVICES (CONTINUED) STANDARDS AND CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD...

  4. Providing Physical Activity for Students with Intellectual Disabilities: The Motivate, Adapt, and Play Program

    ERIC Educational Resources Information Center

    Davis, Kathy; Hodson, Patricia; Zhang, Guili; Boswell, Boni; Decker, Jim

    2010-01-01

    Research has shown that regular physical activity helps to prevent major health problems, such as heart disease, obesity, and diabetes. However, little research has been conducted on classroom-based physical activity programs for students with disabilities. In North Carolina, the Healthy Active Children Policy was implemented in 2006, requiring…

  5. GKTC ACTIVITIES TO PROVIDE NUCLEAR MATERIAL PHYSICAL PROTECTION, CONTROL AND ACCOUNTING TRAINING FOR 2011-2012

    SciTech Connect

    Romanova, Olena; Gavrilyuk, Victor I.; Kirischuk, Volodymyr; Gavrilyuk-Burakova, Anna; Diakov, Oleksii; Drapey, Sergiy; Proskurin, Dmitry; Dickman, Deborah A.; Ferguson, Ken

    2011-10-01

    The GKTC was created at the Kyiv Institute of Nuclear Research as a result of collaborative efforts between the United States and Ukraine. The GKTC has been designated by the Ukrainian Government to provide the MPC&A training and methodological assistance to nuclear facilities and nuclear specialists. In 2010 the GKTC has conducted the planned assessment of training needs of Ukrainian MPC&A specialists. The objective of this work is to acquire the detailed information about the number of MPC&A specialists and guard personnel, who in the coming years should receive the further advanced training. As a result of the performed training needs evaluation the GKTC has determined that in the coming years a number of new training courses need to be developed. Some training courses are already in the process of development. Also taking into account the specific of activity on the guarding of nuclear facilities, GKTC has begun to develop the specialized training courses for the guarding unit personnel. The evaluation of needs of training of Ukrainian specialists on the physical protection shows that without the technical base of learning is not possible to satisfy the needs of Ukrainian facilities, in particular, the need for further training of specialists who maintains physical protection technical means, provides vulnerability assessment and testing of technical means. To increase the training effectiveness and create the basis for specialized training courses holding the GKTC is now working on the construction of an Interior (non-classified) Physical Protection Training Site. The objective of this site is to simulate the actual conditions of the nuclear facility PP system including the complex of engineering and technical means that will help the GKTC training course participants to consolidate the knowledge and gain the practical skills in the work with PP system engineering and technical means for more effective performance of their official duties. This paper briefly

  6. Making friends for hydro: Providing recreational opportunities

    SciTech Connect

    Cosgrove, J.M. )

    1991-07-01

    One northeastern U.S. utility has been forming friendly ties with the public, offering recreation amenities at its hydro projects. As a result, the company has a strong base of public support as it enters relicensing.

  7. Telementoring: Providing Authentic Learning Opportunities for Students.

    ERIC Educational Resources Information Center

    Adams, Helen

    1999-01-01

    Describes the Hewlett Packard (HP) E-Mail Mentoring Program. Lists the program's four main components (teacher contacts, student participants, HP employee members, HP itself) and the application process. Relates how a library media specialist at Rosholt (Wisconsin) High School experienced the program. Concludes with the benefits of…

  8. Increasing Student Physical Activity during the School Day: Opportunities for the Physical Educator

    ERIC Educational Resources Information Center

    Brewer, Joan D.; Luebbers, Paul E.; Shane, Shawna D.

    2009-01-01

    America is facing an obesity epidemic--one that is difficult to ignore. In order to combat the nation's obesity crisis, it is imperative that schools find ways to increase the physical activity levels of students during the school day, as well as encourage additional activity outside of school. By teaching youth to incorporate physical activity…

  9. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the HHS Common Rule at 45 CFR part 76. (b) Reporting requirements Independent Diagnostic Testing... enrolling and maintaining active enrollment status in the Medicare program. 424.516 Section 424.516 Public... active enrollment status in the Medicare program. (a) Certifying compliance. CMS enrolls and maintains...

  10. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the HHS Common Rule at 45 CFR part 76. (b) Reporting requirements Independent Diagnostic Testing... enrolling and maintaining active enrollment status in the Medicare program. 424.516 Section 424.516 Public... active enrollment status in the Medicare program. (a) Certifying compliance. CMS enrolls and maintains...

  11. Service Providers' Perceptions of Active Ageing among Older Adults with Lifelong Intellectual Disabilities

    ERIC Educational Resources Information Center

    Buys, L.; Aird, R.; Miller, E.

    2012-01-01

    Background: Considerable attention is currently being directed towards both active ageing and the revising of standards for disability services within Australia and internationally. Yet, to date, no consideration appears to have been given to ways to promote active ageing among older adults with intellectual disabilities (IDs). Methods:…

  12. 36 CFR 218.24 - Notification of opportunity to comment on proposed projects and activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROJECT-LEVEL PREDECISIONAL ADMINISTRATIVE REVIEW PROCESS Provisions Specific to Project-Level Proposals Not Authorized Under Healthy Forests Restoration... on a proposed project or activity implementing a land management plan. (2) Determine the...

  13. 36 CFR 218.24 - Notification of opportunity to comment on proposed projects and activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PROJECT-LEVEL PREDECISIONAL ADMINISTRATIVE REVIEW PROCESS Provisions Specific to Project-Level Proposals Not Authorized Under Healthy Forests Restoration... on a proposed project or activity implementing a land management plan. (2) Determine the...

  14. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... career plans, including career awareness and planning assistance as they relate to a rigorous academic curriculum. (f) Providing special programs or tutoring in science, technology, engineering, or...

  15. Physical Activity Opportunities during the School Day: Classroom Teachers' Perceptions of Using Activity Breaks in the Classroom

    ERIC Educational Resources Information Center

    McMullen, Jaimie; Kulinna, Pamela; Cothran, Donetta

    2014-01-01

    The purpose of this study was to explore classroom teachers' perceptions of incorporating physical activity breaks into their classroom and to determine specific features of preferred activity breaks. These perceptions are considered within the conceptual framework of Comprehensive School Physical Activity Program (CSPAP). Twelve elementary…

  16. Physical activity when young provides lifelong benefits to cortical bone size and strength in men.

    PubMed

    Warden, Stuart J; Mantila Roosa, Sara M; Kersh, Mariana E; Hurd, Andrea L; Fleisig, Glenn S; Pandy, Marcus G; Fuchs, Robyn K

    2014-04-01

    The skeleton shows greatest plasticity to physical activity-related mechanical loads during youth but is more at risk for failure during aging. Do the skeletal benefits of physical activity during youth persist with aging? To address this question, we used a uniquely controlled cross-sectional study design in which we compared the throwing-to-nonthrowing arm differences in humeral diaphysis bone properties in professional baseball players at different stages of their careers (n = 103) with dominant-to-nondominant arm differences in controls (n = 94). Throwing-related physical activity introduced extreme loading to the humeral diaphysis and nearly doubled its strength. Once throwing activities ceased, the cortical bone mass, area, and thickness benefits of physical activity during youth were gradually lost because of greater medullary expansion and cortical trabecularization. However, half of the bone size (total cross-sectional area) and one-third of the bone strength (polar moment of inertia) benefits of throwing-related physical activity during youth were maintained lifelong. In players who continued throwing during aging, some cortical bone mass and more strength benefits of the physical activity during youth were maintained as a result of less medullary expansion and cortical trabecularization. These data indicate that the old adage of "use it or lose it" is not entirely applicable to the skeleton and that physical activity during youth should be encouraged for lifelong bone health, with the focus being optimization of bone size and strength rather than the current paradigm of increasing mass. The data also indicate that physical activity should be encouraged during aging to reduce skeletal structural decay.

  17. Selective ligand behaviors provide new insights into agonist activation of nicotinic acetylcholine receptors.

    PubMed

    Marotta, Christopher B; Rreza, Iva; Lester, Henry A; Dougherty, Dennis A

    2014-05-16

    Nicotinic acetylcholine receptors are a diverse set of ion channels that are essential to everyday brain function. Contemporary research studies selective activation of individual subtypes of receptors, with the hope of increasing our understanding of behavioral responses and neurodegenerative diseases. Here, we aim to expand current binding models to help explain the specificity seen among three activators of α4β2 receptors: sazetidine-A, cytisine, and NS9283. Through mutational analysis, we can interchange the activation profiles of the stoichiometry-selective compounds sazetidine-A and cytisine. In addition, mutations render NS9283--currently identified as a positive allosteric modulator--into an agonist. These results lead to two conclusions: (1) occupation at each primary face of an α subunit is needed to activate the channel and (2) the complementary face of the adjacent subunit dictates the binding ability of the agonist.

  18. LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages.

    PubMed

    Stephan, Alexander; Batinica, Marina; Steiger, Julia; Hartmann, Pia; Zaucke, Frank; Bloch, Wilhelm; Fabri, Mario

    2016-08-01

    As part of the innate host response neutrophils release neutrophil extracellular traps (NETs), protein:DNA complexes that contain a number of antimicrobial peptides (AMPs), such as cathelicidin. Human cathelicidin in its active form, LL37, has potent antimicrobial activity against bacteria. However, whether LL37 derived from NETs contributes to antimicrobial activity against intracellular pathogens remains unclear. Here, we report that NETs induced by mycobacteria contain cathelicidin. Human macrophages internalized NET-bound cathelicidin, which is transported to lysosomal compartments. Furthermore, using a model of in vitro-generated LL37:DNA complexes we found that LL37 derived from such complexes attacks mycobacteria in macrophage phagolysosomes resulting in antimicrobial activity. Taken together, our results suggest a mechanism by which LL37 in complex with DNA contributes to host defence against intracellular bacteria in human macrophages.

  19. Physical activity, sedentary behaviour and energy balance in the preschool child: opportunities for early obesity prevention.

    PubMed

    Reilly, John J

    2008-08-01

    Prevalence of obesity in preschool children has increased dramatically in recent years. The preschool years (age 3-6 years) have been regarded as critical for the programming of energy balance, via the concept of early 'adiposity rebound'. Children who undergo early adiposity rebound are at increased risk of later obesity. Recent evidence suggests that associations between timing of adiposity rebound and later obesity may not reflect programming, but might denote that 'obesogenic' growth trajectories are often established by the preschool period. Studies of objectively-measured physical activity and sedentary behaviour in preschool children show that levels of physical activity are typically low and sedentary behaviour high. The review of evidence presented here is supportive of the hypothesis that physical activity is protective against obesity in the preschool period, and that sedentary behaviour, particularly television viewing, is obesogenic. Definitive evidence on dose-response relationships between physical activity, sedentary behaviour and obesity remain unclear. Dose-response evidence could be obtained fairly readily by intervention and longitudinal observational studies that use accelerometry in preschool children. The generalisability of much of the evidence base is limited and there is a need for research on the influence of physical activity and sedentary behaviour in the preschool years in the aetiology of obesity in the developing world.

  20. Soil Microbial Activity Provides Insight to Carbon Cycling in Shrub Ecotones of Sub-Arctic Sweden

    NASA Astrophysics Data System (ADS)

    Marek, E.; Kashi, N. N.; Chen, J.; Hobbie, E. A.; Schwan, M. R.; Varner, R. K.

    2015-12-01

    Shrubs are expanding in Arctic and sub-Arctic regions due to rising atmospheric temperatures. Microbial activity increases as growing temperatures cause permafrost warming and subsequent thaw, leading to a greater resource of soil nutrients enabling shrub growth. Increased carbon inputs from shrubs is predicted to result in faster carbon turnover by microbial decomposition. Further understanding of microbial activity underneath shrubs could uncover how microbes and soil processes interact to promote shrub expansion and carbon cycling. To address how higher soil carbon input from shrubs influences decomposition, soil samples were taken across a heath, shrub, and forest ecotone gradient at two sites near Abikso, Sweden. Samples were analyzed for soluble carbon and nitrogen, microbial abundance, and microbial activity of chitinase, glucosidase, and phosphatase to reflect organic matter decomposition and availability of nitrogen, carbon, and phosphate respectively. Chitinase activity positively correlated with shrub cover, suggesting microbial demands for nitrogen increase with higher shrub cover. Glucosidase activity negatively correlated with shrub cover and soluble carbon, suggesting decreased microbial demand for carbon as shrub cover and carbon stores increase. Lower glucosidase activity in areas with high carbon input from shrubs implies that microbes are decomposing carbon less readily than carbon is being put into the soil. Increasing soil carbon stores in shrub covered areas can lead to shrubs becoming a net carbon sink and a negative feedback to changing climate.

  1. Opportunities for Increased Physical Activity in the Workplace: the Walking Meeting (WaM) Pilot Study, Miami, 2015

    PubMed Central

    Kling, Hannah E.; Yang, Xuan; Messiah, Sarah E.; Arheart, Kristopher L.; Brannan, Debi

    2016-01-01

    Introduction Despite the positive impact walking has on human health, few opportunities exist for workers with largely sedentary jobs to increase physical activity while at work. The objective of this pilot study was to examine the implementation, feasibility, and acceptability of using a Walking Meeting (WaM) protocol to increase the level of work-related physical activity among a group of sedentary white-collar workers. Methods White-collar workers at a large university were invited to participate in a newly developed WaM protocol. Workers who conducted weekly meetings in groups of 2 or 3 individuals were recruited for the pilot study (n = 18) that took place from January 2015 to August 2015. Seventeen participants wore an accelerometer to measure physical activity levels during 3 consecutive weeks (first week baseline, followed by 2 weeks of organized WaMs) and participated in focus groups conducted during week 3 to document experiences with the WaM protocol. Results The WaM protocol met study criteria on feasibility, implementation, and acceptability among study participants. The average number of minutes (standard deviation) participants engaged in combined work-related moderate/vigorous physical activity per week during the 3 weeks increased from an average of 107 (55) minutes during the baseline week to 114 (67) minutes at week 2 and to 117 (65) minutes at week 3. Conclusion White- collar workers were supportive of transforming regular seated meetings into walking meetings and increased their work-related physical activity levels. PMID:27337560

  2. State opportunities for action: Update of states' combined heat and power activities

    SciTech Connect

    Brown, Elizabeth; Elliott, R. Neal

    2003-10-01

    This report updates the review of state policies with regard to CHP that the American Council for and Energy Efficient Economy completed in 2002. It describes the current activities of states with programs during the initial survey and also reviews new programs offered by the states.

  3. NASA’s Soil Moisture Active Passive (SMAP) mission and opportunities for applications users

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil Moisture Active Passive (SMAP) mission is one of four first-tier missions recommended by the National Research Council's Committee on Earth Science and Applications from Space. Set to launch in 2014, SMAP soil moisture and freeze/thaw measurements will have an accuracy, resolution, and glob...

  4. FOSTERING APPLICATIONS OPPORTUNITIES FOR THE NASA SOIL MOISTURE ACTIVE PASSIVE (SMAP) MISSION

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil Moisture Active Passive (SMAP) Mission is one of the first Earth observation satellites being developed by NASA in response to the National Research Council’s (NRC’s) Decadal Survey, Earth Science and Applications from Space: National Imperatives for the Next Decade and Beyond. SMAP will ma...

  5. Institutional Review Boards at Very High Research Activity Universities: An Opportunity for Social Workers

    ERIC Educational Resources Information Center

    Cannon, Clare; Buttell, Frederick

    2015-01-01

    Objectives: This study investigated to what degree social work was represented in the position of chair of social-behavioral institutional review boards (IRBs) at very high research activity (VHRA) universities in the United States. Method: We collected data on IRB rosters for all 108 schools designated by the Carnegie Foundation as VHRAs in the…

  6. The Online GVP/USGS Weekly Volcanic Activity Report: Providing Timely Information About Worldwide Volcanism

    NASA Astrophysics Data System (ADS)

    Mayberry, G. C.; Guffanti, M. C.; Luhr, J. F.; Venzke, E. A.; Wunderman, R. L.

    2001-12-01

    The awesome power and intricate inner workings of volcanoes have made them a popular subject with scientists and the general public alike. About 1500 known volcanoes have been active on Earth during the Holocene, approximately 50 of which erupt per year. With so much activity occurring around the world, often in remote locations, it can be difficult to find up-to-date information about current volcanism from a reliable source. To satisfy the desire for timely volcano-related information the Smithsonian Institution and US Geological Survey combined their strengths to create the Weekly Volcanic Activity Report. The Smithsonian's Global Volcanism Program (GVP) has developed a network of correspondents while reporting worldwide volcanism for over 30 years in their monthly Bulletin of the Global Volcanism Network. The US Geological Survey's Volcano Hazards Program studies and monitors volcanoes in the United States and responds (upon invitation) to selected volcanic crises in other countries. The Weekly Volcanic Activity Report is one of the most popular sites on both organization's websites. The core of the Weekly Volcanic Activity Report is the brief summaries of current volcanic activity around the world. In addition to discussing various types of volcanism, the summaries also describe precursory activity (e.g. volcanic seismicity, deformation, and gas emissions), secondary activity (e.g. debris flows, mass wasting, and rockfalls), volcanic ash hazards to aviation, and preventative measures. The summaries are supplemented by links to definitions of technical terms found in the USGS photoglossary of volcano terms, links to information sources, and background information about reported volcanoes. The site also includes maps that highlight the location of reported volcanoes, an archive of weekly reports sorted by volcano and date, and links to commonly used acronyms. Since the Weekly Volcanic Activity Report's inception in November 2000, activity has been reported at

  7. Opportunities for Low Cost Processing of Erbium 8-Quinolinolates for Active Integrated Photonic Applications.

    PubMed

    Penna, Stefano; Mattiello, Leonardo; Di Bartolo, Silvia; Pizzoleo, Angelo; Attanasio, Vincenzo; Beleffi, Giorgio Maria Tosi; Otomo, Akira

    2016-04-01

    Erbium-doped organic emitters are promising active materials for Photonic Integrated Circuits (PICs) due to their emission shown at 1550 nm combined to the potential low cost processing. In particular, Erbium Quinoline (ErQ) gained a strong interest in the last decade for the good emission efficiency. This contribution reports the results derived from the application of ErQ as active core material within a buried optical waveguide, following the development of a purposed optical process to control the refractive index of ErQ and then to define a patterned structure from a single thin film deposition step. The reported results show the potential of Er-doped organic materials for low cost processing and application to planar PICs. PMID:27451632

  8. Opportunities for Low Cost Processing of Erbium 8-Quinolinolates for Active Integrated Photonic Applications.

    PubMed

    Penna, Stefano; Mattiello, Leonardo; Di Bartolo, Silvia; Pizzoleo, Angelo; Attanasio, Vincenzo; Beleffi, Giorgio Maria Tosi; Otomo, Akira

    2016-04-01

    Erbium-doped organic emitters are promising active materials for Photonic Integrated Circuits (PICs) due to their emission shown at 1550 nm combined to the potential low cost processing. In particular, Erbium Quinoline (ErQ) gained a strong interest in the last decade for the good emission efficiency. This contribution reports the results derived from the application of ErQ as active core material within a buried optical waveguide, following the development of a purposed optical process to control the refractive index of ErQ and then to define a patterned structure from a single thin film deposition step. The reported results show the potential of Er-doped organic materials for low cost processing and application to planar PICs.

  9. Star Power: Providing for the Gifted & Talented. Module 5. Enrichment Activities for the Gifted/Talented.

    ERIC Educational Resources Information Center

    Mallis, Jackie; Gilman, Sharlene

    The document presents Module 5, enrichment activities for the gifted/talented, of the Star Power modules developed for school personnel who have an interest in or a need to explore the area of gifted and talented education. It is explained in an introductory section that the modules can be used for independent study, for small group interaction,…

  10. Effects of providing a nutrition education program for teenagers: dietary and physical activity patterns.

    PubMed

    Tse, Mimi M Y; Yuen, Dorothy T W

    2009-06-01

    This study enhanced nutritional knowledge in an education program and encouraged healthy dietary habits and regular physical activity among teenagers. A total of 203 adolescents from a secondary school in Hong Kong took part in the study. Their Body Mass Index, dietary habits, and physical exercise pattern were recorded and examined before and after the health education program. The prevalence of overweight and obesity, together with the fat composition, were high among the participants before the nutrition education program. There was a marked gain in knowledge upon its completion. A follow-up action conducted 3 months later revealed positive outcomes in relation to the diet and physical activity level. The teenagers were able to take control of their health and requested the tuck shop to sell more healthy food and reduce the supply of unhealthy items. The educational initiatives in dietary habits and physical activities proved to be effective in encouraging the teenagers to eat more healthily and to adopt an active lifestyle.

  11. NASA plans and opportunities. [space flight activities throughout the 1990s

    NASA Technical Reports Server (NTRS)

    Sulzman, Frank M.

    1991-01-01

    The NASA plans for the Life Science program of a series of space flight activities throughout the decade of the 1990s are discussed with particular attention given to the NASA life science goals and objectives and to the particular space missions which will carry out these objectives. These space missions and specially designed facilities for experiments in space include Space Station Freedom, Space Biology Initiative, Gravitational Biology Facility, Life Sciences Centrifuge Facility, Controlled Ecological Life Support Systems Test Facility, and Exobiology Facility.

  12. A new paradigm for quarantine and public health activities at land borders: opportunities and challenges.

    PubMed

    Waterman, Stephen H; Escobedo, Miguel; Wilson, Todd; Edelson, Paul J; Bethel, Jeffrey W; Fishbein, Daniel B

    2009-01-01

    The Institute of Medicine (IOM) report Quarantine Stations at Ports of Entry: Protecting the Public's Health focused almost exclusively on U.S. airports and seaports, which served 106 million entries in 2005. IOM concluded that the primary function of these quarantine stations (QSs) should shift from providing inspection to providing strategic national public health leadership. The large expanse of our national borders, large number of crossings, sparse federal resources, and decreased regulation regarding conveyances crossing these borders make land borders more permeable to a variety of threats. To address the health challenges related to land borders, the QSs serving such borders must assume unique roles and partnerships to achieve the strategic leadership and public health research roles envisioned by the IOM. In this article, we examine how the IOM recommendations apply to the QSs that serve the land borders through which more than 319 million travelers, immigrants, and refugees entered the U.S. in 2005.

  13. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., writing, study skills, mathematics, science, and other subjects. (2) Advice and assistance in... services: (1) Individualized counseling for personal, career, and academic matters provided by assigned... project with the range of career options available to the students. (3) Exposure to cultural events...

  14. Spontaneous symmetry breaking in active droplets provides a generic route to motility

    PubMed Central

    Tjhung, Elsen; Marenduzzo, Davide; Cates, Michael E.

    2012-01-01

    We explore a generic mechanism whereby a droplet of active matter acquires motility by the spontaneous breakdown of a discrete symmetry. The model we study offers a simple representation of a “cell extract” comprising, e.g., a droplet of actomyosin solution. (Such extracts are used experimentally to model the cytoskeleton). Actomyosin is an active gel whose polarity describes the mean sense of alignment of actin fibres. In the absence of polymerization and depolymerization processes (‘treadmilling’), the gel’s dynamics arises solely from the contractile motion of myosin motors; this should be unchanged when polarity is inverted. Our results suggest that motility can arise in the absence of treadmilling, by spontaneous symmetry breaking (SSB) of polarity inversion symmetry. Adapting our model to wall-bound cells in two dimensions, we find that as wall friction is reduced, treadmilling-induced motility falls but SSB-mediated motility rises. The latter might therefore be crucial in three dimensions where frictional forces are likely to be modest. At a supracellular level, the same generic mechanism can impart motility to aggregates of nonmotile but active bacteria; we show that SSB in this (extensile) case leads generically to rotational as well as translational motion. PMID:22797894

  15. Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities.

    PubMed

    Huang, Xinyan; Dale, Elena; Brodbeck, Robbin M; Doller, Dario

    2014-01-01

    Drug design necessitates a clear understanding of the phenotypic response to be elicited by a given ligandtarget interaction. This relationship is relatively well understood for classical biological targets of drug action, but for some novel targets, notably those amenable to allosteric modulation, developing such understanding may represent a more challenging task. In order to gain knowledge on the nature of the functional response derived from mGlu4 receptor activation, its molecular and cell biology are reviewed, including signalling pathways involved, receptor localization in central nervous system and beyond, and potential genetic links to disease. Broadly held views for both, orthosteric agonists as well as allosteric modulators, are compared with specific observations for the case of mGlu4 receptor activation via orthosteric and allosteric mechanisms. First, sub-type selectivity and brain penetration of amino acid mGlu4 receptor agonists are discussed, followed by the quantification of functional allosteric effects, the potential role of heterodimers in the functional response, and the observation of supra-physiological efficacy of mGlu4 receptor PAMs. We show that, in our analysis, these attributes differ from those that may be expected by extrapolating from broad knowledge. In addition, recent progress with mGlu4 receptor radioligands and PET ligands is summarized.

  16. Activity-based funding model provides foundation for province-wide best practices in renal care.

    PubMed

    Levin, Adeera; Lo, Clifford; Noel, Kevin; Djurdjev, Ogjnenka; Amano, Erlyn C

    2013-01-01

    British Columbia has a unique funding model for renal care in Canada. Patient care is delivered through six health authorities, while funding is administered by the Provincial Renal Agency using an activity-based funding model. The model allocates funding based on a schedule of costs for every element of renal care, excluding physician fees. Accountability, transparency of allocation and tracking of outcomes are key features that ensure successful implementation. The model supports province-wide best practices and equitable care and fosters innovation. Since its introduction, the outpatient renal services budget has grown less than the population, while maintaining or improving clinical outcomes. PMID:24485244

  17. Equal Opportunities for Women in Marine Sciences in Kiel: Activities and Measures

    NASA Astrophysics Data System (ADS)

    Kamm, Ruth

    2016-04-01

    Women are still largely underrepresented in geosciences in general. Particularly at the level of professorships and permanent research staff positions this also applies to marine science institutions in Kiel, i.e. the research focus Kiel Marine Sciences at Kiel University and the GEOMAR Helmholtz Centre for Ocean Research Kiel. Both institutions are closely collaborating, for instance in the frame of two major third-party funded collaborative projects: The Cluster of Excellence 'The Future Ocean', funded within the German Excellence Initiative, and the Collaborative Research Centre 'Climate - Biogeochemistry Interactions in the Tropical Ocean' (SFB 754) financed through the German Research Foundation (DFG). Both funding schemes request for measures to increase the participation of female scientists in leading positions. As an innovative approach, The Future Ocean and SFB 754 jointly finance the position of a coordinator for gender measures who is based at the university's Central Office for Gender Equality, Diversity & Family since 2012. This allows for the coordinated development and implementation of programmes to support female marine scientists, with a focus on the postdoctoral phase, and to offer a broader spectrum of activities to raise awareness of gender imbalance in the research community. The aim of this presentation is to give insight into activities and achievements, among them the mentoring programme via:mento_ocean for female postdocs in marine sciences. The programme via:mento_ocean has been acknowledged as a best practice instrument to support women scientists in a close disciplinary but international setting and was incorporated into the DFG's online toolbox of gender equality measures.

  18. The role of provider-patient communication and trust in online sources in Internet use for health-related activities.

    PubMed

    Hou, Jiran; Shim, Minsun

    2010-01-01

    Provider-patient communication is an important factor influencing patients' satisfaction and health outcomes. This study draws upon the uses and gratification theory to examine how individuals' perception of communication with healthcare providers is associated with their Internet use for health-related activities. Using the data from the 2007 Health Information National Trends Survey (HINTS), we found that as individuals perceived their communication with providers to be less patient-centered, they were more likely to engage in various types of online health activities, such as using websites for healthy lifestyles, searching for healthcare providers, and seeking health information. Trust in online health information was also found to be a significant predictor of online health activities. The results of this study emphasized the important role of provider-patient communication in motivating individuals to turn to the Internet for health purposes. PMID:21154093

  19. Hawai'i's Opportunity for Active Living Advancement (HO'ĀLA): addressing childhood obesity through safe routes to school.

    PubMed

    Heinrich, Katie M; Dierenfield, Laura; Alexander, Daniel A; Prose, Marcia; Peterson, Ann C

    2011-07-01

    Increasing active transportation to and from school may reduce childhood obesity rates in Hawai'i. A community partnership was formed to address this issue in Hawai'i's Opportunity for Active Living Advancement (HO'ĀLA), a quasi-experimental study of active transportation in Hawai'i County. The purpose of this study was to determine baseline rates for active transportation rates to and from school and to track changes related to macro-level (statewide) policy, locally-based Safe Routes to School (SRTS) programs and bicycle and pedestrian planning initiatives expected to improve the safety, comfort and ease of walking and bicycling to and from school. Measures included parent surveys, student travel tallies, traffic counts and safety observations. Assessments of the walking and biking environment around each school were made using the Pedestrian Environment Data Scan. Complete Streets and SRTS policy implementation was tracked through the activities of a state transportation-led Task Force and an advocacy-led coalition, respectively. Planning initiatives were tracked through citizen-based advisory committees. Thirteen volunteer schools participated as the intervention (n=8) or comparison (n=5) schools. The majority of students were Asian, Native Hawaiian, and Pacific Islander in schools located in under-resourced communities. Overall, few children walked or biked to school. The majority of children were driven to and from school by their parents. With the influence of HO'ĀLA staff members, two intervention schools were obligated SRTS project funding from the state, schools were identified as key areas in the pedestrian master plan, and one intervention school was slated for a bike plan priority project. As the SRTS programs are implemented in the next phase of the project, post-test data will be collected to ascertain if changes in active transportation rates occur.

  20. Mitochondrial function provides instructive signals for activation-induced B-cell fates.

    PubMed

    Jang, Kyoung-Jin; Mano, Hiroto; Aoki, Koji; Hayashi, Tatsunari; Muto, Akihiko; Nambu, Yukiko; Takahashi, Katsu; Itoh, Katsuhiko; Taketani, Shigeru; Nutt, Stephen L; Igarashi, Kazuhiko; Shimizu, Akira; Sugai, Manabu

    2015-04-10

    During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we show a strong association between individual B-cell fates and mitochondrial functions. CSR occurs specifically in activated B cells with increased mitochondrial mass and membrane potential, which augment mitochondrial reactive oxygen species (mROS), whereas PCD occurs in cells with decreased mitochondrial mass and potential. These events are consequences of initial slight changes in mROS in mitochondria(high) B-cell populations. In CSR-committed cells, mROS attenuates haeme synthesis by inhibiting ferrous ion addition to protoporphyrin IX, thereby maintaining Bach2 function. Reduced mROS then promotes PCD by increasing haeme synthesis. In PCD-committed cells, Blimp1 reduces mitochondrial mass, thereby reducing mROS levels. Identifying mROS as a haeme synthesis regulator increases the understanding of mechanisms regulating haeme homeostasis and cell fate determination after B-cell activation.

  1. 20 CFR 669.680 - What activities and services may be provided under the MSFW youth program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... services that conform to the use of funds for youth activities described in 20 CFR part 664. ... under the MSFW youth program? 669.680 Section 669.680 Employees' Benefits EMPLOYMENT AND TRAINING... INVESTMENT ACT The MSFW Youth Program § 669.680 What activities and services may be provided under the...

  2. 20 CFR 669.680 - What activities and services may be provided under the MSFW youth program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... services that conform to the use of funds for youth activities described in 20 CFR part 664. ... under the MSFW youth program? 669.680 Section 669.680 Employees' Benefits EMPLOYMENT AND TRAINING... INVESTMENT ACT The MSFW Youth Program § 669.680 What activities and services may be provided under the...

  3. 20 CFR 669.680 - What activities and services may be provided under the MSFW youth program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under the MSFW youth program? 669.680 Section 669.680 Employees' Benefits EMPLOYMENT AND TRAINING... the use of funds for youth activities described in 20 CFR part 664. ... ACT The MSFW Youth Program § 669.680 What activities and services may be provided under the MSFW...

  4. 20 CFR 669.680 - What activities and services may be provided under the MSFW youth program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under the MSFW youth program? 669.680 Section 669.680 Employees' Benefits EMPLOYMENT AND TRAINING... the use of funds for youth activities described in 20 CFR part 664. ... ACT The MSFW Youth Program § 669.680 What activities and services may be provided under the MSFW...

  5. Seizing Opportunity: "Opportunity as Transformation"

    ERIC Educational Resources Information Center

    Williams, Michael; Muller, Esther

    2012-01-01

    Opportunity creates conditions for achievement. We learn daily of the success of others that resulted from conditions they created through opportunity. Often these conditions of opportunity are the product of a compelling vision of a future steeped in possibility and rich in reward. These visions, however, must be operationalized in order to be…

  6. Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

    PubMed Central

    Chatterjee, Arunita; Roy, Debasish; Patnaik, Esha

    2016-01-01

    ABSTRACT Muscle contraction brings about movement and locomotion in animals. However, muscles have also been implicated in several atypical physiological processes including immune response. The role of muscles in immunity and the mechanism involved has not yet been deciphered. In this paper, using Drosophila indirect flight muscles (IFMs) as a model, we show that muscles are immune-responsive tissues. Flies with defective IFMs are incapable of mounting a potent humoral immune response. Upon immune challenge, the IFMs produce anti-microbial peptides (AMPs) through the activation of canonical signaling pathways, and these IFM-synthesized AMPs are essential for survival upon infection. The trunk muscles of zebrafish, a vertebrate model system, also possess the capacity to mount an immune response against bacterial infections, thus establishing that immune responsiveness of muscles is evolutionarily conserved. Our results suggest that physiologically fit muscles might boost the innate immune response of an individual. PMID:27101844

  7. Two Adaptation Processes in Auditory Hair Cells Together Can Provide an Active Amplifier

    PubMed Central

    Vilfan, Andrej; Duke, Thomas

    2003-01-01

    The hair cells of the vertebrate inner ear convert mechanical stimuli to electrical signals. Two adaptation mechanisms are known to modify the ionic current flowing through the transduction channels of the hair bundles: a rapid process involves Ca2+ ions binding to the channels; and a slower adaptation is associated with the movement of myosin motors. We present a mathematical model of the hair cell which demonstrates that the combination of these two mechanisms can produce “self-tuned critical oscillations”, i.e., maintain the hair bundle at the threshold of an oscillatory instability. The characteristic frequency depends on the geometry of the bundle and on the Ca2+ dynamics, but is independent of channel kinetics. Poised on the verge of vibrating, the hair bundle acts as an active amplifier. However, if the hair cell is sufficiently perturbed, other dynamical regimes can occur. These include slow relaxation oscillations which resemble the hair bundle motion observed in some experimental preparations. PMID:12829475

  8. The Cost of Dengue Vector Control Activities in Malaysia by Different Service Providers.

    PubMed

    Packierisamy, P Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Venugopalan, B; Halasa, Yara A; Shepard, Donald S

    2015-11-01

    We examined variations in dengue vector control costs and resource consumption between the District Health Departments (DHDs) and Local Authorities (LAs) to assist informed decision making as to the future roles of these agencies in the delivery of dengue vector control services in Malaysia. Data were collected from the vector control units of DHDs and LAs in 8 selected districts. We captured costs and resource consumption in 2010 for premise inspection for mosquito breeding sites, fogging to destroy adult mosquitoes and larviciding of potential breeding sites. Overall, DHDs spent US$5.62 million or US$679 per case and LAs spent US$2.61 million or US$499 per case. The highest expenditure for both agencies was for fogging, 51.0% and 45.8% of costs for DHDs and LAs, respectively. The DHDs had higher resource costs for human personnel, vehicles, pesticides, and equipment. The findings provide some evidence to rationalize delivery of dengue vector control services in Malaysia.

  9. Does the survivorship of activated resting stages in toxic environments provide cues for ballast water treatment?

    PubMed

    Alekseev, Victor; Makrushin, Andrey; Hwang, Jiang-Shiou

    2010-01-01

    The toxic effects of three inorganic metals (Cu, Cr, Hg), three organic (phenol, formalin, ammonium) chemicals, ozone-enriched water and peroxides (H2O2) on embryonic development were tested in 8 species from the Porifera, Bryozoa and Crustacea. Toxicants with lower molecular weight showed stronger negative impacts on post-diapause embryos than chemicals with higher molecular weight if related to the toxicity of the chemicals to active adult stages. Only few embryos of the cladoceran Moina macrocopa and none of the cladoceran Wlassicsia pannonica treated with peroxides at concentration 0.3% developed further. Ozone-enriched water had no significant effect on post-diapause embryonic development in cladocerans. Ammonium (the product of NH4OH dissociation) in concentration 100 mg/l and higher killed all embryos of M. macrocopa inside protective membranes. Peroxides and ammonium are suggested for the purification of ship ballast waters as effective, non-expensive and non-persistent toxic chemicals. Resting stages of invertebrates including at least Crustaceans, Porifera and Bryozoa seem to allow not only dispersal among toxic industrial environments such as ship ballast compartments, but may also endure serious pollution events common in seaports and estuaries. Artemia cysts due to their strong protection against different toxic substances are recommended as a model for studies of toxic effects in diapausing stages in polluted estuaries and marine environments. PMID:20356608

  10. Does the survivorship of activated resting stages in toxic environments provide cues for ballast water treatment?

    PubMed

    Alekseev, Victor; Makrushin, Andrey; Hwang, Jiang-Shiou

    2010-01-01

    The toxic effects of three inorganic metals (Cu, Cr, Hg), three organic (phenol, formalin, ammonium) chemicals, ozone-enriched water and peroxides (H2O2) on embryonic development were tested in 8 species from the Porifera, Bryozoa and Crustacea. Toxicants with lower molecular weight showed stronger negative impacts on post-diapause embryos than chemicals with higher molecular weight if related to the toxicity of the chemicals to active adult stages. Only few embryos of the cladoceran Moina macrocopa and none of the cladoceran Wlassicsia pannonica treated with peroxides at concentration 0.3% developed further. Ozone-enriched water had no significant effect on post-diapause embryonic development in cladocerans. Ammonium (the product of NH4OH dissociation) in concentration 100 mg/l and higher killed all embryos of M. macrocopa inside protective membranes. Peroxides and ammonium are suggested for the purification of ship ballast waters as effective, non-expensive and non-persistent toxic chemicals. Resting stages of invertebrates including at least Crustaceans, Porifera and Bryozoa seem to allow not only dispersal among toxic industrial environments such as ship ballast compartments, but may also endure serious pollution events common in seaports and estuaries. Artemia cysts due to their strong protection against different toxic substances are recommended as a model for studies of toxic effects in diapausing stages in polluted estuaries and marine environments.

  11. The Cost of Dengue Vector Control Activities in Malaysia by Different Service Providers.

    PubMed

    Packierisamy, P Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Venugopalan, B; Halasa, Yara A; Shepard, Donald S

    2015-11-01

    We examined variations in dengue vector control costs and resource consumption between the District Health Departments (DHDs) and Local Authorities (LAs) to assist informed decision making as to the future roles of these agencies in the delivery of dengue vector control services in Malaysia. Data were collected from the vector control units of DHDs and LAs in 8 selected districts. We captured costs and resource consumption in 2010 for premise inspection for mosquito breeding sites, fogging to destroy adult mosquitoes and larviciding of potential breeding sites. Overall, DHDs spent US$5.62 million or US$679 per case and LAs spent US$2.61 million or US$499 per case. The highest expenditure for both agencies was for fogging, 51.0% and 45.8% of costs for DHDs and LAs, respectively. The DHDs had higher resource costs for human personnel, vehicles, pesticides, and equipment. The findings provide some evidence to rationalize delivery of dengue vector control services in Malaysia. PMID:26047628

  12. RECREATIONAL AND CULTURAL OPPORTUNITIES.

    ERIC Educational Resources Information Center

    BELDON, RENA

    RECREATIONAL AND CULTURAL OPPORTUNITIES FOR MOST RURAL YOUTH ARE CENTERED AROUND SCHOOLS, BUT WITH INCREASING EMPHASIS ON ACADEMIC SUBJECTS THE STUDENTS ARE BEING DEPRIVED OF OPPORTUNITIES TO PARTICIPATE IN CERTAIN ACTIVITIES FOR ENJOYMENT ONLY. SUGGESTIONS INCLUDE TAKING THE PERFORMING ARTS TO THE RURAL AREAS, PLANNING ART FESTIVALS THAT WOULD…

  13. RECREATION AND CULTURAL OPPORTUNITIES.

    ERIC Educational Resources Information Center

    HARVEY, ELLEN E.

    RECREATIONAL ACTIVITIES AND OPPORTUNITIES SEEM TO BE CLOSELY INVOLVED WITH THE FEDERAL GOVERNMENT, BOTH IN FINANCIAL SUPPORT AND IN THE ACTUAL OPPORTUNITIES POSSIBLE. CONSEQUENTLY, THE TIME IS RIPE FOR THE ORIGIN AND/OR DEVELOPMENT OF ONE OR MORE NEW AGENCIES WITH THE INTERESTS AND NEEDS OF MODERN YOUTH AS THE LEVER FOR THEIR BEGINNING. TO…

  14. Time-driven activity-based costing of multivessel coronary artery bypass grafting across national boundaries to identify improvement opportunities: study protocol

    PubMed Central

    Erhun, F; Mistry, B; Platchek, T; Milstein, A; Narayanan, V G; Kaplan, R S

    2015-01-01

    Introduction Coronary artery bypass graft (CABG) surgery is a well-established, commonly performed treatment for coronary artery disease—a disease that affects over 10% of US adults and is a major cause of morbidity and mortality. In 2005, the mean cost for a CABG procedure among Medicare beneficiaries in the USA was $32 201±$23 059. The same operation reportedly costs less than $2000 to produce in India. The goals of the proposed study are to (1) identify the difference in the costs incurred to perform CABG surgery by three Joint Commission accredited hospitals with reputations for high quality and efficiency and (2) characterise the opportunity to reduce the cost of performing CABG surgery. Methods and analysis We use time-driven activity-based costing (TDABC) to quantify the hospitals’ costs of producing elective, multivessel CABG. TDABC estimates the costs of a given clinical service by combining information about the process of patient care delivery (specifically, the time and quantity of labour and non-labour resources utilised to perform each activity) with the unit cost of each resource used to provide the care. Resource utilisation was estimated by constructing CABG process maps for each site based on observation of care and staff interviews. Unit costs were calculated as a capacity cost rate, measured as a $/min, for each resource consumed in CABG production. Multiplying together the unit costs and resource quantities and summing across all resources used will produce the average cost of CABG production at each site. We will conclude by conducting a variance analysis of labour costs to reveal opportunities to bend the cost curve for CABG production in the USA. Ethics and dissemination All our methods were exempted from review by the Stanford Institutional Review Board. Results will be published in peer-reviewed journals and presented at scientific meetings. PMID:26307621

  15. Ambivalence about smoking and cue-elicited neural activity in quitting-motivated smokers faced with an opportunity to smoke.

    PubMed

    Wilson, Stephen J; Creswell, Kasey G; Sayette, Michael A; Fiez, Julie A

    2013-02-01

    Many cigarette smokers appear to experience ambivalence about smoking, defined as the simultaneous co-occurrence of a strong desire to smoke and a strong wish to quit smoking. Research suggests that this ambivalence about smoking affects how smokers respond to cigarette-related stimuli, but many important questions remain about precisely how smoking ambivalence influences cognitive and affective processing during cigarette cue exposure. We used functional magnetic resonance imaging (fMRI) to address this knowledge gap by examining the relation between self-reported ambivalence about smoking and cue-reactivity in quitting-motivated smokers presented with an opportunity to smoke. Eighty-two quitting-motivated cigarette smokers completed a measure assessing their ambivalence about smoking. Subsequently, participants initiated an attempt to quit smoking and underwent an fMRI session, during which they were asked to hold and view a cigarette. Consistent with hypotheses, results indicated that self-reported smoking ambivalence was negatively correlated with cigarette-related activation in brain areas linked to reward-related processing, motivation, and attention (i.e., rostral anterior cingulate and medial prefrontal cortex, caudate nucleus, visual cortex). Self-reported ambivalence was not, however, correlated with activation in brain regions related to conflict processing. This pattern of results is discussed with respect to the process of change for those attempting to quit smoking.

  16. Providing for Different Rates of Music Learning.

    ERIC Educational Resources Information Center

    Beer, Alice S.; And Others

    1982-01-01

    Discusses ways that elementary music teachers can design class activities which will meet individual needs of mainstreamed special students. Activities described encompass a wide range of difficulty and provide opportunities for individualized, small-group or out-of-class instruction and for creative response. (AM)

  17. Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

    PubMed Central

    Sun, Meiyan; Deng, Bin; Zhao, Xiaoyong; Gao, Changjun; Yang, Lu; Zhao, Hui; Yu, Daihua; Zhang, Feng; Xu, Lixian; Chen, Lei; Sun, Xude

    2015-01-01

    Excessive microglial activation often contributes to inflammation-mediated neurotoxicity in the ischemic penumbra during the acute stage of ischemic stroke. Toll-like receptor 4 (TLR4) has been reported to induce microglial activation via the NF-κB pathway. Isoflurane preconditioning (IP) can provide neuroprotection and inhibit microglial activation. In this study, we investigated the roles of the TLR4 signalling pathway in IP to exert neuroprotection following ischemic stroke in vivo and in vitro. The results showed that 2% IP alleviated neurological deficits, reduced the infarct volume, attenuated apoptosis and weakened microglial activation in the ischemic penumbra. Furthermore, IP down-regulated the expression of HSP 60, TLR4 and MyD88 and up-regulated inhibitor of IκB-α expression compared with I/R group in vivo. In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1β, TNF-α and Bax, and up-regulated IκB-α and Bcl-2 expression compared with OGD group. Moreover, IP and CLI-095 attenuated microglial activation-induced neuronal apoptosis, and overexpression of the TLR4 gene reversed the neuroprotective effects of IP. In conclusion, IP provided neuroprotection by regulating TLR4 expression directly, alleviating microglial activation and neuroinflammation. Thus, inhibiting the activation of microglial activation via TLR4 may be a new avenue for stroke treatment. PMID:26086415

  18. Space Educational Opportunities and Outreach Activities at the Dawn of the 21st Century. A European Students Perspective

    NASA Astrophysics Data System (ADS)

    Ferretti, S.; Robinson, D.; Manfletti, C.; Amadori, K.; Boccalatte, A.; Alessandrini, M.; Bedogna, P.; Corradi, P.; Marcuccio, M.

    2002-01-01

    Taking part in space activities and participating in the development and growth of space project has now become an undeniable reality. Thanks to academic institutions and outreach activities space enthusiasts can engage in numerous and diverse yet unique opportunities. The ESA Outreach Office sees students of every background taking part in its activities. This unique mixture of students of diverse nationalities enthusiastically co-operating ensures the program's interdisciplinarity. The added value of such an environment to the programs is significant and must not be forgotten. The friendship that blossom, and lose with which cultural and language barriers are overcome during the time spent working on the projects offered to university student and young professionals are invaluable. The purpose of this abstract is to give our perspective to the space community and to the general public on the importance of developing a space culture. The academic value of the space research projects mainly in which the authors have participated, the importance of such projects for the future of European relations and personal and social development through experience of international teams are topics that will be addressed. The activities discussed are : Attending sessions of congresses around the world, making contacts of major companies and players in the space sector, dealing of topics such as space engineering, policy and law, life sciences, business and finance, satellite applications, the exhilaration of floating in zero-g, the interdisciplinary, international and intercultural approach, the chance of quickly learning about many new concepts are just some of the marvellous experiences and opportunities that these programs offer. Reaching out to the general public is the second purpose of these unique activities.Images, photos and reports can seep into every house thanks to the great instrument that is the media, thus informing almost everyone about the activities and

  19. Weight management including dietary and physical activity advice provided by Australian physiotherapists: a pilot cross-sectional survey.

    PubMed

    Snodgrass, Suzanne J; Carter, Amy E; Guest, Maya; Collins, Clare E; James, Carole; Kable, Ashley K; Ashby, Samantha E; Plotnikoff, Ronald C

    2014-08-01

    Physiotherapists may have an impact on obesity prevention and treatment by providing nutrition and physical activity advice to overweight or obese clients; yet little is known about physiotherapists' beliefs and practices related to client weight management. The aim of this pilot study was to determine the practices, beliefs, attitudes and knowledge of physiotherapists regarding the provision of weight management advice to overweight or obese clients. Physiotherapists (n = 65) working in multiple practice settings completed a self-administered questionnaire. Logistic regression determined factors associated with the provision of dietary and physical activity advice for weight management. The majority of physiotherapists (n = 53 [81.5%]) believed providing weight management advice was within their scope of practice, yet only a minority had received training during their professional entry level education (n = 13 [20%]) or through professional development (n = 7 [11%]). Most physiotherapists (n = 55 [84.6%]) provided physical activity advice for weight management, but a minority (n = 27 [41.5%]) provided dietary advice. Having received training in weight management during their professional entry level education was associated with providing dietary advice (Odds ratio 8.8, 95% confidence interval 2.0-38.9, p = 0.004). Training in weight management may increase the likelihood of physiotherapists providing dietary advice, improving physiotherapists' management of obesity.

  20. A Bill to Provide for Affording Equal Educational Opportunities for Students in the Nation's Elementary and Secondary Schools; 94th Congress, 1st Session, H.R. 10146, in the House of Representatives, October 9, 1975.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House.

    This document contains the components of the National Educational Opportunities Act of 1975. Among the purposes of this Act are the provision for a viable mechanism for States and their local educational systems to implement the national policy on equal educational opportunity, the improvement of results achieved by elementary and secondary…

  1. Usability and acceptability of a website that provides tailored advice on falls prevention activities for older people.

    PubMed

    Nyman, Samuel R; Yardley, Lucy

    2009-03-01

    This article presents the usability and acceptability of a website that provides older people with tailored advice to help motivate them to undertake physical activities that prevent falls. Views on the website from interviews with 16 older people and 26 sheltered housing wardens were analysed thematically. The website was well received with only one usability difficulty with the action plan calendar. The older people selected balance training activities out of interest or enjoyment, and appeared to carefully add them into their current routine. The wardens were motivated to promote the website to their residents, particularly those who owned a computer, had balance problems, or were physically active. However, the participants noted that currently a minority of older people use the Internet. Also, some older people underestimated how much activity was enough to improve balance, and others perceived themselves as too old for the activities.

  2. Systematic Development of the YouRAction program, a computer-tailored Physical Activity promotion intervention for Dutch adolescents, targeting personal motivations and environmental opportunities

    PubMed Central

    2010-01-01

    Background Increasing physical activity (PA) among adolescents is an important health promotion goal. PA has numerous positive health effects, but the majority of Dutch adolescents do not meet PA requirements. The present paper describes the systematic development of a theory-based computer-tailored intervention, YouRAction, which targets individual and environmental factors determining PA among adolescents. Design The intervention development was guided by the Intervention Mapping protocol, in order to define clear program objectives, theoretical methods and practical strategies, ensure systematic program planning and pilot-testing, and anticipate on implementation and evaluation. Two versions of YouRAction were developed: one that targets individual determinants and an extended version that also provides feedback on opportunities to be active in the neighbourhood. Key determinants that were targeted included: knowledge and awareness, attitudes, self-efficacy and subjective norms. The extended version also addressed perceived availability of neighbourhood PA facilities. Both versions aimed to increase levels of moderate-to-vigorous PA among adolescents. The intervention structure was based on self-regulation theory, comprising of five steps in the process of successful goal pursuit. Monitoring of PA behaviour and behavioural and normative feedback were used to increase awareness of PA behaviour; motivation was enhanced by targeting self-efficacy and attitudes, by means of various interactive strategies, such as web movies; the perceived environment was targeted by visualizing opportunities to be active in an interactive geographical map of the home environment; in the goal setting phase, the adolescents were guided in setting a goal and developing an action plan to achieve this goal; in the phase of active goal pursuit adolescents try to achieve their goal and in the evaluation phase the achievements are evaluated. Based on the results of the evaluation

  3. Enhancing Recognition of High Quality, Functional IFSP Outcomes: A Training Activity for Infant and Toddler Service Providers

    ERIC Educational Resources Information Center

    Lucas, Anne; Gillaspy, Kathi; Peters, Mary Louise; Hurth, Joicey

    2014-01-01

    This training activity was created to support participants' understanding of the criteria needed to develop and write high quality, participation-based Individualized Family Service Plan (IFSP) outcomes. The term "functional" is often used to describe what outcomes ought to be, yet many providers struggle to define what makes an outcome…

  4. A Context-Aware Ubiquitous Learning Approach for Providing Instant Learning Support in Personal Computer Assembly Activities

    ERIC Educational Resources Information Center

    Hsu, Ching-Kun; Hwang, Gwo-Jen

    2014-01-01

    Personal computer assembly courses have been recognized as being essential in helping students understand computer structure as well as the functionality of each computer component. In this study, a context-aware ubiquitous learning approach is proposed for providing instant assistance to individual students in the learning activity of a…

  5. Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury.

    PubMed

    Sen, Tanusree; Sen, Nilkantha

    2016-08-01

    Traumatic brain injury (TBI) is one of the major cause of morbidity and mortality and it affects more than 1.7 million people in the USA. A couple of regenerative pathways including activation of hypoxia-inducible transcription factor 1 alpha (HIF-1α) are initiated to reduce cellular damage following TBI; however endogenous activation of these pathways is not enough to provide neuroprotection after TBI. Thus we aimed to see whether sustained activation of HIF-1α can provide neuroprotection and neurorepair following TBI. We found that chronic treatment with dimethyloxaloylglycine (DMOG) markedly increases the expression level of HIF-1α and mRNA levels of its downstream proteins such as Vascular endothelial growth factor (VEGF), Phosphoinositide-dependent kinase-1 and 4 (PDK1, PDK4) and Erythropoietin (EPO). Treatment of DMOG activates a major cell survival protein kinase Akt and reduces both cell death and lesion volume following TBI. Moreover, administration of DMOG augments cluster of differentiation 31 (CD31) staining in pericontusional cortex after TBI, which suggests that DMOG stimulates angiogenesis after TBI. Treatment with DMOG also improves both memory and motor functions after TBI. Taken together our results suggest that sustained activation of HIF-1α provides significant neuroprotection following TBI. PMID:26970014

  6. Promoting changes in diet and physical activity in breast and colorectal cancer screening settings: an unexplored opportunity for endorsing healthy behaviors.

    PubMed

    Anderson, Annie S; Mackison, Dionne; Boath, Callum; Steele, Robert

    2013-03-01

    The importance of diet, physical activity, and weight management in breast and colorectal cancer prevention is widely recognized. While there may be many "teachable moments" that could be used to assess and initiate changes in these behaviors by health professionals (to complement public health campaigns), there is little evidence that lifestyle is discussed within cancer screening settings. The lack of advocacy about lifestyle in these settings may endorse poor health behaviors, in particular the absence of guidance to visibly obese patients. To fully use the teachable moment, patients need to be aware of the relationship between diet and physical activity and the risk of cancer and to be able to relate guidance to personal behaviors. Results from cardiovascular and diabetes prevention programs provide evidence about the components of effective behavior change programs which could be used in the screening setting. Findings from interventions initiated in the colorectal cancer screening setting suggest that such programs can be delivered but it is not clear how acceptable these are in routine health services. Effective interventions delivered in this setting also offer an important opportunity to contribute to the reduction of the overall burden of chronic non-communicable diseases. PMID:23324132

  7. The Volunteering-in-Place (VIP) Program: Providing meaningful volunteer activity to residents in assisted living with mild cognitive impairment.

    PubMed

    Klinedinst, N Jennifer; Resnick, Barbara

    2016-01-01

    The Volunteering-in-Place (VIP) Program was developed to provide individualized meaningful volunteer activities matched to interests and capabilities for older adults with MCI in assisted living. The purposes of this single-site pre-test/post-test pilot study were to (1) establish feasibility of the VIP Program based on treatment fidelity (design, treatment, delivery, enactment); and (2) evaluate preliminary efficacy via improvement in psychological health (depressive symptoms, usefulness, purpose, resilience, and life satisfaction) and decreased sedentary activity (survey and Fitbit) at 3 and 6 months. Ten residents participated. The majority was white, female and educated, and on average 88 years old. The VIP Program was feasible and most participants continued to volunteer at 6 months. There were non-significant improvements in depressive symptoms, usefulness, purpose, resilience and recreational physical activity. The results of this study provide support for the feasibility of the VIP Program. Further study is necessary to examine efficacy.

  8. China takes an active role in combating an Ebola outbreak: On-site observations and reflections from a Chinese healthcare provider

    PubMed Central

    Lu, Hongzhou

    2015-01-01

    Summary As one of the active participants in the global fight against the 2014 outbreak of Ebola virus disease (EVD) in West Africa, China supplied many resources, including medical experts and scientists as well as medical supplies, to the affected countries. A member of the first contingent of Chinese public health experts who worked in Sierra Leone for 65 days, I am pleased to have this opportunity to review the major work done by our team to help deal with the Ebola epidemic in Sierra Leone. This is the first time that a Chinese public health training team has worked in West Africa. The team provides trainings for people from local communities in an effort to encourage local residents to get involved in the war against Ebola. However, the implementation of active measures against Ebola in West Africa was hampered somewhat by certain drawbacks in the area in terms of the health system, the shortage of medical resources, the high illiteracy rate, unhealthy lifestyles, and traditional funeral rites. All of these aspects need to be gradually improved in the aftermath of Ebola, and I believe that this is an area in which the Chinese public health system can play an important role. PMID:26668785

  9. China takes an active role in combating an Ebola outbreak: On-site observations and reflections from a Chinese healthcare provider.

    PubMed

    Lu, Hongzhou

    2015-11-01

    As one of the active participants in the global fight against the 2014 outbreak of Ebola virus disease (EVD) in West Africa, China supplied many resources, including medical experts and scientists as well as medical supplies, to the affected countries. A member of the first contingent of Chinese public health experts who worked in Sierra Leone for 65 days, I am pleased to have this opportunity to review the major work done by our team to help deal with the Ebola epidemic in Sierra Leone. This is the first time that a Chinese public health training team has worked in West Africa. The team provides trainings for people from local communities in an effort to encourage local residents to get involved in the war against Ebola. However, the implementation of active measures against Ebola in West Africa was hampered somewhat by certain drawbacks in the area in terms of the health system, the shortage of medical resources, the high illiteracy rate, unhealthy lifestyles, and traditional funeral rites. All of these aspects need to be gradually improved in the aftermath of Ebola, and I believe that this is an area in which the Chinese public health system can play an important role.

  10. Planning Human Resource Development through Equal Opportunities. A Handbook.

    ERIC Educational Resources Information Center

    Warwick, Jill

    This handbook is intended for managers who wish to develop human resources in their organizations, particularly where women are currently underrepresented. It provides a positive model for the successful equal opportunities manager and a checklist of activities that will lead to the successful implementation of equal opportunities. The handbook…

  11. New Suborbital Flight Opportunities and Funding

    NASA Astrophysics Data System (ADS)

    Saltman, Alexander

    2013-07-01

    New opportunities for suborbital research are on the horizon. Reusable suborbital vehicles will offer immediate and routine space access for scientific payloads, provide access to altitudes around 100 kilometers, create opportunities for low-cost monitoring of upper atmospheric phenomena, as well as small scale solar observation. Reduced operational cost and quick turn-around will enable equipment to be flown opportunistically, in response to specific solar activity, or in continuous test and improvement cycles. Suborbital test flights will also provide opportunities to test prospective satellite instruments in an extended microgravity environment before being launched to orbit, raising the technology readiness level (TRL) of flight hardware and reducing the risk of anomalies during missions. I discuss the capabilities of emerging suborbital vehicles, payload and integration requirements, and funding opportunities for suborbital flights at NASA.

  12. A qualitative study of women’s perceptions of provider advice about diet and physical activity during pregnancy

    PubMed Central

    Ferrari, Renée M.; Siega-Riz, Anna Maria; Evenson, Kelly R.; Moos, Merry-K.; Carrier, Kathryn S.

    2013-01-01

    OBJECTIVE The purpose of this qualitative study was to gather insights into pregnant women’s experiences with provider advice about diet and physical activity. METHODS We conducted a series of 13 focus groups with a total of 58 pregnant African American, Caucasian, and Hispanic women of varying body sizes. Statements were independently coded, reduced, and then reconstructed to identify overarching themes with the assistance of ATLAS/ti software. RESULTS Mean gestational age at the time of the focus groups was 30 weeks. Women commonly reported overwhelming and confusing diet advice and a paucity of physical activity advice that was largely limited to walking. Many reported following advice; when advice was not followed, it was because women disagreed with it or simply did not want to do it. CONCLUSION Women would benefit from more clear guidance from physicians and other providers regarding dietary choices and physical activity in pregnancy. PRACTICE IMPLICATIONS Providers should make dietary and physical activity advice in pregnancy more clear and individualized and offer such guidance multiple times throughout pregnancy. PMID:23399436

  13. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

    PubMed

    Filbin, Mariella Gruber; Dabral, Sukriti K; Pazyra-Murphy, Maria F; Ramkissoon, Shakti; Kung, Andrew L; Pak, Ekaterina; Chung, Jarom; Theisen, Matthew A; Sun, Yanping; Franchetti, Yoko; Sun, Yu; Shulman, David S; Redjal, Navid; Tabak, Barbara; Beroukhim, Rameen; Wang, Qi; Zhao, Jean; Dorsch, Marion; Buonamici, Silvia; Ligon, Keith L; Kelleher, Joseph F; Segal, Rosalind A

    2013-11-01

    In glioblastoma, phosphatidylinositol 3-kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor phosphatase and tensin homolog (PTEN). However, it is not known whether inhibiting PI3K represents a selective and effective approach for treatment. We interrogated large databases and found that sonic hedgehog (SHH) signaling is activated in PTEN-deficient glioblastoma. We demonstrate that the SHH and PI3K pathways synergize to promote tumor growth and viability in human PTEN-deficient glioblastomas. A combination of PI3K and SHH signaling inhibitors not only suppressed the activation of both pathways but also abrogated S6 kinase (S6K) signaling. Accordingly, targeting both pathways simultaneously resulted in mitotic catastrophe and tumor apoptosis and markedly reduced the growth of PTEN-deficient glioblastomas in vitro and in vivo. The drugs tested here appear to be safe in humans; therefore, this combination may provide a new targeted treatment for glioblastoma. PMID:24076665

  14. Young, Healthy Subjects Can Reduce the Activity of Calf Muscles When Provided with EMG Biofeedback in Upright Stance.

    PubMed

    Vieira, Taian M; Baudry, Stéphane; Botter, Alberto

    2016-01-01

    Recent evidence suggests the minimization of muscular effort rather than of the size of bodily sway may be the primary, nervous system goal when regulating the human, standing posture. Different programs have been proposed for balance training; none however has been focused on the activation of postural muscles during standing. In this study we investigated the possibility of minimizing the activation of the calf muscles during standing through biofeedback. By providing subjects with an audio signal that varied in amplitude and frequency with the amplitude of surface electromyograms (EMG) recorded from different regions of the gastrocnemius and soleus muscles, we expected them to be able to minimize the level of muscle activation during standing without increasing the excursion of the center of pressure (CoP). CoP data and surface EMG from gastrocnemii, soleus and tibialis anterior muscles were obtained from 10 healthy participants while standing at ease and while standing with EMG biofeedback. Four sensitivities were used to test subjects' responsiveness to the EMG biofeedback. Compared with standing at ease, the two most sensitive feedback conditions induced a decrease in plantar flexor activity (~15%; P < 0.05) and an increase in tibialis anterior EMG (~10%; P < 0.05). Furthermore, CoP mean position significantly shifted backward (~30 mm). In contrast, the use of less sensitive EMG biofeedback resulted in a significant decrease in EMG activity of ankle plantar flexors with a marginal increase in TA activity compared with standing at ease. These changes were not accompanied by greater CoP displacements or significant changes in mean CoP position. Key results revealed subjects were able to keep standing stability while reducing the activity of gastrocnemius and soleus without loading their tibialis anterior muscle when standing with EMG biofeedback. These results may therefore posit the basis for the development of training protocols aimed at assisting subjects in

  15. Young, Healthy Subjects Can Reduce the Activity of Calf Muscles When Provided with EMG Biofeedback in Upright Stance

    PubMed Central

    Vieira, Taian M.; Baudry, Stéphane; Botter, Alberto

    2016-01-01

    Recent evidence suggests the minimization of muscular effort rather than of the size of bodily sway may be the primary, nervous system goal when regulating the human, standing posture. Different programs have been proposed for balance training; none however has been focused on the activation of postural muscles during standing. In this study we investigated the possibility of minimizing the activation of the calf muscles during standing through biofeedback. By providing subjects with an audio signal that varied in amplitude and frequency with the amplitude of surface electromyograms (EMG) recorded from different regions of the gastrocnemius and soleus muscles, we expected them to be able to minimize the level of muscle activation during standing without increasing the excursion of the center of pressure (CoP). CoP data and surface EMG from gastrocnemii, soleus and tibialis anterior muscles were obtained from 10 healthy participants while standing at ease and while standing with EMG biofeedback. Four sensitivities were used to test subjects' responsiveness to the EMG biofeedback. Compared with standing at ease, the two most sensitive feedback conditions induced a decrease in plantar flexor activity (~15%; P < 0.05) and an increase in tibialis anterior EMG (~10%; P < 0.05). Furthermore, CoP mean position significantly shifted backward (~30 mm). In contrast, the use of less sensitive EMG biofeedback resulted in a significant decrease in EMG activity of ankle plantar flexors with a marginal increase in TA activity compared with standing at ease. These changes were not accompanied by greater CoP displacements or significant changes in mean CoP position. Key results revealed subjects were able to keep standing stability while reducing the activity of gastrocnemius and soleus without loading their tibialis anterior muscle when standing with EMG biofeedback. These results may therefore posit the basis for the development of training protocols aimed at assisting subjects in

  16. Public Schools and Equal Educational Opportunity

    ERIC Educational Resources Information Center

    Green, Robert L.

    1974-01-01

    Discusses several steps necessary to obtaining equal educational opportunities. These include placing better teaching staffs in urban schools, providing extensive field work for student teachers interested in teaching minority children, reevaluating the current curriculum for occurrences of racism and devising extracurricular activities for…

  17. Mutational activation of niche-specific genes provides insight into regulatory networks and bacterial function in a complex environment

    PubMed Central

    Giddens, Stephen R.; Jackson, Robert W.; Moon, Christina D.; Jacobs, Michael A.; Zhang, Xue-Xian; Gehrig, Stefanie M.; Rainey, Paul B.

    2007-01-01

    The genome of the plant-colonizing bacterium Pseudomonas fluorescens SBW25 harbors a subset of genes that are expressed specifically on plant surfaces. The function of these genes is central to the ecological success of SBW25, but their study poses significant challenges because no phenotype is discernable in vitro. Here, we describe a genetic strategy with general utility that combines suppressor analysis with IVET (SPyVET) and provides a means of identifying regulators of niche-specific genes. Central to this strategy are strains carrying operon fusions between plant environment-induced loci (EIL) and promoterless ′dapB. These strains are prototrophic in the plant environment but auxotrophic on laboratory minimal medium. Regulatory elements were identified by transposon mutagenesis and selection for prototrophs on minimal medium. Approximately 106 mutants were screened for each of 27 strains carrying ′dapB fusions to plant EIL and the insertion point for the transposon determined in approximately 2,000 putative regulator mutants. Regulators were functionally characterized and used to provide insight into EIL phenotypes. For one strain carrying a fusion to the cellulose-encoding wss operon, five different regulators were identified including a diguanylate cyclase, the flagella activator, FleQ, and alginate activator, AmrZ (AlgZ). Further rounds of suppressor analysis, possible by virtue of the SPyVET strategy, revealed an additional two regulators including the activator AlgR, and allowed the regulatory connections to be determined. PMID:17989226

  18. [Active surveillance of adverse drug reaction in the era of big data: challenge and opportunity for control selection].

    PubMed

    Wang, S F; Zhan, S Y

    2016-07-01

    Electronic healthcare databases have become an important source for active surveillance of drug safety in the era of big data. The traditional epidemiology research designs are needed to confirm the association between drug use and adverse events based on these datasets, and the selection of the comparative control is essential to each design. This article aims to explain the principle and application of each type of control selection, introduce the methods and parameters for method comparison, and describe the latest achievements in the batch processing of control selection, which would provide important methodological reference for the use of electronic healthcare databases to conduct post-marketing drug safety surveillance in China. PMID:27453095

  19. [Active surveillance of adverse drug reaction in the era of big data: challenge and opportunity for control selection].

    PubMed

    Wang, S F; Zhan, S Y

    2016-07-01

    Electronic healthcare databases have become an important source for active surveillance of drug safety in the era of big data. The traditional epidemiology research designs are needed to confirm the association between drug use and adverse events based on these datasets, and the selection of the comparative control is essential to each design. This article aims to explain the principle and application of each type of control selection, introduce the methods and parameters for method comparison, and describe the latest achievements in the batch processing of control selection, which would provide important methodological reference for the use of electronic healthcare databases to conduct post-marketing drug safety surveillance in China.

  20. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.

    PubMed

    Molitor, Christian; Mauracher, Stephan Gerhard; Rompel, Annette

    2016-03-29

    Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs). Tyrosinases catalyze theo-hydroxylation and oxidation of phenolic compounds, whereas catechol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation of o-diphenolic compounds. Aurone synthase from Coreopsis grandiflora (AUS1) is a specialized plant PPO involved in the anabolic pathway of aurones. We present, to our knowledge, the first crystal structures of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding histidine. Analysis of the latent proenzyme's interface between the shielding C-terminal domain and the main core provides insights into its activation mechanisms. As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzyme is classified as a catechol oxidase. However, AUS1 showed hydroxylase activity toward its natural substrate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptance of common tyrosinase substrates. Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs. Molecular dynamics simulations of docked substrate-enzyme complexes were performed, and a key residue was identified that influences the plant PPO's acceptance or rejection of tyramine. Based on the evidenced hydroxylase activity and the interactions of specific residues with the substrates during the molecular dynamics simulations, a novel catalytic reaction mechanism for plant PPOs is proposed. The presented results strongly suggest that the physiological role of plant catechol oxidases were previously underestimated, as they might hydroxylate their--so far unknown--natural substrates in vivo.

  1. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.

    PubMed

    Molitor, Christian; Mauracher, Stephan Gerhard; Rompel, Annette

    2016-03-29

    Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs). Tyrosinases catalyze theo-hydroxylation and oxidation of phenolic compounds, whereas catechol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation of o-diphenolic compounds. Aurone synthase from Coreopsis grandiflora (AUS1) is a specialized plant PPO involved in the anabolic pathway of aurones. We present, to our knowledge, the first crystal structures of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding histidine. Analysis of the latent proenzyme's interface between the shielding C-terminal domain and the main core provides insights into its activation mechanisms. As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzyme is classified as a catechol oxidase. However, AUS1 showed hydroxylase activity toward its natural substrate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptance of common tyrosinase substrates. Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs. Molecular dynamics simulations of docked substrate-enzyme complexes were performed, and a key residue was identified that influences the plant PPO's acceptance or rejection of tyramine. Based on the evidenced hydroxylase activity and the interactions of specific residues with the substrates during the molecular dynamics simulations, a novel catalytic reaction mechanism for plant PPOs is proposed. The presented results strongly suggest that the physiological role of plant catechol oxidases were previously underestimated, as they might hydroxylate their--so far unknown--natural substrates in vivo. PMID:26976571

  2. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases

    PubMed Central

    Molitor, Christian; Mauracher, Stephan Gerhard

    2016-01-01

    Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs). Tyrosinases catalyze the o-hydroxylation and oxidation of phenolic compounds, whereas catechol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation of o-diphenolic compounds. Aurone synthase from Coreopsis grandiflora (AUS1) is a specialized plant PPO involved in the anabolic pathway of aurones. We present, to our knowledge, the first crystal structures of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding histidine. Analysis of the latent proenzyme’s interface between the shielding C-terminal domain and the main core provides insights into its activation mechanisms. As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzyme is classified as a catechol oxidase. However, AUS1 showed hydroxylase activity toward its natural substrate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptance of common tyrosinase substrates. Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs. Molecular dynamics simulations of docked substrate–enzyme complexes were performed, and a key residue was identified that influences the plant PPO’s acceptance or rejection of tyramine. Based on the evidenced hydroxylase activity and the interactions of specific residues with the substrates during the molecular dynamics simulations, a novel catalytic reaction mechanism for plant PPOs is proposed. The presented results strongly suggest that the physiological role of plant catechol oxidases were previously underestimated, as they might hydroxylate their—so far unknown—natural substrates in vivo. PMID:26976571

  3. Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly.

    PubMed

    Spitzer, Dirk; Mitchell, Lynne M; Atkinson, John P; Hourcade, Dennis E

    2007-08-15

    Complement promotes the rapid recognition and elimination of pathogens, infected cells, and immune complexes. The biochemical basis for its target specificity is incompletely understood. In this report, we demonstrate that properdin can directly bind to microbial targets and provide a platform for the in situ assembly and function of the alternative pathway C3 convertases. This mechanism differs from the standard model wherein nascent C3b generated in the fluid phase attaches nonspecifically to its targets. Properdin-directed complement activation occurred on yeast cell walls (zymosan) and Neisseria gonorrhoeae. Properdin did not bind wild-type Escherichia coli, but it readily bound E. coli LPS mutants, and the properdin-binding capacity of each strain correlated with its respective serum-dependent AP activation rate. Moreover, properdin:single-chain Ab constructs were used to direct serum-dependent complement activation to novel targets. We conclude properdin participates in two distinct complement activation pathways: one that occurs by the standard model and one that proceeds by the properdin-directed model. The properdin-directed model is consistent with a proposal made by Pillemer and his colleagues >50 years ago. PMID:17675523

  4. 75 FR 5804 - Small and Medium-Sized Enterprises: U.S. and EU Export Activities, and Barriers and Opportunities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... published in the Federal Registers of October 28, 2009 (74 FR 55581); December 1, 2009 (74 FR 62812); and.... SMEs face in their efforts to export. The strategies that SMEs have adopted to address or overcome those constraints. The benefits to SMEs of increased export opportunities from free trade agreements...

  5. Investigative Homework with Apples: An Opportunity for Primary-School Students to Learn Actively the Relationship between Density and Flotation

    ERIC Educational Resources Information Center

    Radovanovic, Jelena; Sliško, Josip

    2014-01-01

    This paper describes investigative homework with apples, aiming to contribute to the primary-school students' understanding of density and conditions leading to floating and sinking. The assignment represents an opportunity for individual autonomous learning of physics and adoption of established scientific concepts through practical activities…

  6. Opportunity fuels

    SciTech Connect

    Lutwen, R.C.

    1994-12-31

    Opportunity fuels - fuels that can be converted to other forms of energy at lower cost than standard fossil fuels - are discussed in outline form. The type and source of fuels, types of fuels, combustability, methods of combustion, refinery wastes, petroleum coke, garbage fuels, wood wastes, tires, and economics are discussed.

  7. Enhancing Opportunities.

    ERIC Educational Resources Information Center

    Meyers, Michelle J.

    1994-01-01

    Hispanics can enhance their professional career by finding jobs with corporations that offer to pay for graduate tuition. This opportunity has positively influenced the careers of many Hispanics and has proven advantageous for corporations as well by increasing the knowledge and skills of their employees. (LP)

  8. Unequal opportunities.

    PubMed

    Trueland, Jennifer

    There are concerns that the reorganisation of the NHS will reduce opportunities for BME nurses to reach senior positions. This article considers the varied experiences of front line nurses. Several have been passed over for promotion, others have experienced overt racism from patients, while some have never felt discriminated against.

  9. 20 CFR 645.225 - How do Welfare-to-Work activities relate to activities provided through TANF and other related...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS... coordinated effectively at the State and local levels with activities being provided through TANF (section 403... unsubsidized employment in place for each participant which takes into account participant...

  10. Let's Wiggle with 5-2-1-0: Curriculum Development for Training Childcare Providers to Promote Activity in Childcare Settings.

    PubMed

    Vinci, Debra M; Whitt-Glover, Melicia C; Wirth, Christopher K; Kraus, Caroline; Venezia, Alexandra P

    2016-01-01

    Overweight and obesity are increasing in preschool children in the US. Policy, systems, and environmental change interventions in childcare settings can improve obesity-related behaviors. The aim of this study was to develop and pilot an intervention to train childcare providers to promote physical activity (PA) in childcare classrooms. An evidence scan, key informant (n = 34) and focus group (n = 20) interviews with childcare directors and staff, and environmental self-assessment of childcare facilities (n = 22) informed the design of the training curriculum. Feedback from the interviews indicated that childcare providers believed in the importance of teaching children about PA and were supportive of training teachers to incorporate PA into classroom settings. The Promoting Physical Activity in Childcare Setting Curriculum was developed and training was implemented with 16 teachers. Participants reported a positive experience with the hands-on training and reported acquiring new knowledge that they intended to implement in their childcare settings. Our findings highlight the feasibility of working with childcare staff to develop PA training and curriculum. Next steps include evaluating the curriculum in additional childcare settings and childcare staff implementation of the curriculum to understand the effectiveness of the training on PA levels of children. PMID:27462468

  11. Let's Wiggle with 5-2-1-0: Curriculum Development for Training Childcare Providers to Promote Activity in Childcare Settings

    PubMed Central

    Venezia, Alexandra P.

    2016-01-01

    Overweight and obesity are increasing in preschool children in the US. Policy, systems, and environmental change interventions in childcare settings can improve obesity-related behaviors. The aim of this study was to develop and pilot an intervention to train childcare providers to promote physical activity (PA) in childcare classrooms. An evidence scan, key informant (n = 34) and focus group (n = 20) interviews with childcare directors and staff, and environmental self-assessment of childcare facilities (n = 22) informed the design of the training curriculum. Feedback from the interviews indicated that childcare providers believed in the importance of teaching children about PA and were supportive of training teachers to incorporate PA into classroom settings. The Promoting Physical Activity in Childcare Setting Curriculum was developed and training was implemented with 16 teachers. Participants reported a positive experience with the hands-on training and reported acquiring new knowledge that they intended to implement in their childcare settings. Our findings highlight the feasibility of working with childcare staff to develop PA training and curriculum. Next steps include evaluating the curriculum in additional childcare settings and childcare staff implementation of the curriculum to understand the effectiveness of the training on PA levels of children. PMID:27462468

  12. Flexible Learning Opportunities.

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    One way for colleges to meet the demand for a wider range of learning opportunities for adults in Great Britain is to provide more flexibility within the further education system. The concept of flexible learning involves the modification of delivery systems, specific providing agencies, target populations, specific determinants such as geographic…

  13. Fluorogen-activating proteins provide tunable labeling densities for tracking FcεRI independent of IgE.

    PubMed

    Schwartz, Samantha L; Yan, Qi; Telmer, Cheryl A; Lidke, Keith A; Bruchez, Marcel P; Lidke, Diane S

    2015-02-20

    Crosslinking of IgE bound FcεRI on mast cells and basophils by multivalent antigen leads to degranulation and the release of key inflammatory mediators that stimulate the allergic response. Here, we present and characterize the use of fluorogen-activating proteins (FAPs) for single particle tracking of FcεRI to investigate how receptor mobility is influenced after IgE-induced changes in mast cell behavior. FAPs are genetically encoded tags that bind a fluorogen dye and increase its brightness upon binding up to 20,000-fold. We demonstrate that, by titrating fluorogen concentration, labeling densities from ensemble to single particle can be achieved, independent of expression level and without the need for wash steps or photobleaching. The FcεRI γ-subunit fused to a FAP (FAP-γ) provides, for the first time, an IgE-independent probe for tracking this signaling subunit of FcεRI at the single molecule level. We show that the FcεRI γ-subunit dynamics are controlled by the IgE-binding α-subunit and that the cytokinergic IgE, SPE-7, induces mast cell activation without altering FcεRI mobility or promoting internalization. We take advantage of the far-red emission of the malachite green (MG) fluorogen to track FcεRI relative to dynamin-GFP and find that immobilized receptors readily correlate with locations of dynamin recruitment only under conditions that promote rapid endocytosis. These studies demonstrate the usefulness of the FAP system for single molecule studies and have provided new insights into the relationship among FcεRI structure, activity, and mobility. PMID:25343439

  14. Opportunity's Path

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This Long Term Planning graphic was created from a mosaic of navigation camera images overlain by a polar coordinate grid with the center point as Opportunity's original landing site. The blue dots represent the rover position at various locations.

    The red dots represent the center points of the target areas for the instruments on the rover mast (the panoramic camera and miniature thermal emission spectrometer). Opportunity visited Stone Mountain on Feb. 5. Stone Mountain was named after the southernmost point of the Appalachian Mountains outside of Atlanta, Ga. On Earth, Stone Mountain is the last big mountain before the Piedmont flatlands, and on Mars, Stone Mountain is at one end of Opportunity Ledge. El Capitan is a target of interest on Mars named after the second highest peak in Texas in Guadaloupe National Park, which is one of the most visited outcrops in the United States by geologists. It has been a training ground for students and professional geologists to understand what the layering means in relation to the formation of Earth, and scientists will study this prominent point of Opportunity Ledge to understand what the layering means on Mars.

    The yellow lines show the midpoint where the panoramic camera has swept and will sweep a 120-degree area from the three waypoints on the tour of the outcrop. Imagine a fan-shaped wedge from left to right of the yellow line.

    The white contour lines are one meter apart, and each drive has been roughly about 2-3 meters in length over the last few sols. The large white blocks are dropouts in the navigation camera data.

    Opportunity is driving along and taking a photographic panorama of the entire outcrop. Scientists will stitch together these images and use the new mosaic as a 'base map' to decide on geology targets of interest for a more detailed study of the outcrop using the instruments on the robotic arm. Once scientists choose their targets of interest, they plan to study the outcrop for roughly five to

  15. Polarised skylight and the landmark panorama provide night-active bull ants with compass information during route following.

    PubMed

    Reid, Samuel F; Narendra, Ajay; Hemmi, Jan M; Zeil, Jochen

    2011-02-01

    Navigating animals are known to use a number of celestial and terrestrial compass cues that allow them to determine and control their direction of travel. Which of the cues dominate appears to depend on their salience. Here we show that night-active bull ants attend to both the pattern of polarised skylight and the landmark panorama in their familiar habitat. When the two directional cues are in conflict, ants choose a compromise direction. However, landmark guidance appears to be the primary mechanism of navigation used by forager ants, with those cues in the direction of heading having the greatest influence on navigation. Different colonies respond to the removal of these cues to different degrees, depending on the directional information provided by the local landmark panorama. Interestingly, other parts of the surrounding panorama also influence foraging speed and accuracy, suggesting that they too play a role in navigation.

  16. Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health.

    PubMed

    Lv, Xinmiao; Zhao, Siyu; Ning, Zhangchi; Zeng, Honglian; Shu, Yisong; Tao, Ou; Xiao, Cheng; Lu, Cheng; Liu, Yuanyan

    2015-01-01

    Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these fruits have been used as traditional medicinal herbs to cure diseases in several Asian countries. Numerous studies have focused on Citrus secondary metabolites as well as bioactivities and have been intended to develop new chemotherapeutic or complementary medicine in recent decades. Citrus-derived secondary metabolites, including flavonoids, alkaloids, limonoids, coumarins, carotenoids, phenolic acids and essential oils, are of vital importance to human health due to their active properties. These characteristics include anti-oxidative, anti-inflammatory, anti-cancer, as well as cardiovascular protective effects, neuroprotective effects, etc. This review summarizes the global distribution and taxonomy, numerous secondary metabolites and bioactivities of Citrus fruits to provide a reference for further study. Flavonoids as characteristic bioactive metabolites in Citrus fruits are mainly introduced.

  17. Federal Funding Opportunities to Support the P-20W Data Pipeline. Federal Spotlight

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    This publication provides an overview of the current federal opportunities to help states advance their data-related activities. Although not exhaustive, this list provides a starting point for federal policymakers to support states' work in this area.

  18. Chlamydia screening for sexually active young women under the Affordable Care Act: new opportunities and lingering barriers.

    PubMed

    Loosier, Penny S; Malcarney, Mary-Beth; Slive, Lauren; Cramer, Ryan C; Burgess, Brittany; Hoover, Karen W; Romaguera, Raul

    2014-09-01

    The Affordable Care Act of 2010 (ACA) contains a provision requiring private insurers issuing or renewing plans on or after September 23, 2010, to provide, without cost sharing, preventive services recommended by US Preventive Services Task Force (grades A and B), among other recommending bodies. As a grade A recommendation, chlamydia screening for sexually active young women 24 years and younger and older women at risk for chlamydia falls under this requirement. This article examines the potential effect on chlamydia screening among this population across private and public health plans and identifies lingering barriers not addressed by this legislation. Examination of the impact on women with private insurance touches upon the distinction between coverage under grandfathered plans, where the requirement does not apply, and nongrandfathered plans, where the requirement does apply. Acquisition of private health insurance through health insurance Marketplaces is also discussed. For public health plans, coverage of preventive services without cost sharing differs for individuals enrolled in standard Medicaid, covered under the Medicaid expansion included in the ACA, or those enrolled under the Children's Health Insurance Program or who fall under Early, Periodic, Screening, Diagnosis and Treatment criteria. The discussion of lingering barriers not addressed by the ACA includes the uninsured, physician reimbursement, cost sharing, confidentiality, low rates of appropriate sexual history taking by providers, and disclosures of sensitive information. In addition, the role of safety net programs that provide health care to individuals regardless of ability to pay is examined in light of the expectation that they also remain a payer of last resort. PMID:25118966

  19. PV opportunities in India

    NASA Astrophysics Data System (ADS)

    Stone, Jack L.; Ullal, Harin S.

    1996-01-01

    The growing middle class in India, coupled with a need for electricity to provide basic services to the masses, provides an opportunity to deploy photovoltaic systems in cost-effective applications ranging from grid-connected to isolated location requirements. This need is being satisfied by aggressive government programs, the availability of funds from agencies such as the World Bank, and the desire of Indian industries to form joint ventures for in-country manufacturing. The relaxed restrictions on doing business in India makes today's opportunities timely indeed.

  20. Gamma-Irradiated Influenza A Virus Provides Adjuvant Activity to a Co-Administered Poorly Immunogenic SFV Vaccine in Mice

    PubMed Central

    Babb, Rachelle; Chan, Jennifer; Khairat, Jasmine E.; Furuya, Yoichi; Alsharifi, Mohammed

    2014-01-01

    Many currently available inactivated vaccines require “adjuvants” to maximize the protective immune responses generated against the antigens of interest. Recent studies in mice with gamma-irradiated influenza A virus (γ-FLU) have shown its superior efficacy compared to other forms of inactivated FLU vaccines and its ability to induce both potent interferon type-I (IFN-I) responses and the IFN-I-associated partial lymphocyte activation. Commonly, IFN-I responses induced by adjuvants, combined in vaccine preparations, have been shown to effectively enhance the immunogenicity of the antigens of interest. Therefore, we investigated the potential adjuvant activity of γ-FLU and the possible effect on antibody responses against co-administrated antigens, using gamma-irradiated Semliki Forest virus (γ-SFV) as the experimental vaccine in mice. Our data show that co-vaccination with γ-FLU and γ-SFV resulted in enhanced SFV-specific antibody responses in terms of increased titers by sixfold and greater neutralization efficacy, when compared to vaccination with γ-SFV alone. This study provides promising evidence related to the possible use of γ-FLU as an adjuvant to poorly immunogenic vaccines without compromising the vaccine efficacy of γ-FLU. PMID:24959166

  1. Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling

    PubMed Central

    Lin, Chuwen; Yao, Erica; Wang, Kevin; Nozawa, Yoko; Shimizu, Hirohito; Johnson, Jeffrey R.; Chen, Jau-Nian; Krogan, Nevan J.

    2014-01-01

    Control of Gli function by Suppressor of Fused (Sufu), a major negative regulator, is a key step in mammalian Hedgehog (Hh) signaling, but how this is achieved in the nucleus is unknown. We found that Hh signaling results in reduced Sufu protein levels and Sufu dissociation from Gli proteins in the nucleus, highlighting critical functions of Sufu in the nucleus. Through a proteomic approach, we identified several Sufu-interacting proteins, including p66β (a member of the NuRD [nucleosome remodeling and histone deacetylase] repressor complex) and Mycbp (a Myc-binding protein). p66β negatively and Mycbp positively regulate Hh signaling in cell-based assays and zebrafish. They function downstream from the membrane receptors, Patched and Smoothened, and the primary cilium. Sufu, p66β, Mycbp, and Gli are also detected on the promoters of Hh targets in a dynamic manner. Our results support a new model of Hh signaling in the nucleus. Sufu recruits p66β to block Gli-mediated Hh target gene expression. Meanwhile, Mycbp forms a complex with Gli and Sufu without Hh stimulation but remains inactive. Hh pathway activation leads to dissociation of Sufu/p66β from Gli, enabling Mycbp to promote Gli protein activity and Hh target gene expression. These studies provide novel insight into how Sufu controls Hh signaling in the nucleus. PMID:25403183

  2. Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues

    PubMed Central

    2015-01-01

    Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cluster from Streptomyces platensis NRRL 18993. The iso-MGS biosynthetic machinery featured an acyltransferase (AT)-less type I polyketide synthase (PKS) and three tailoring enzymes (MgsIJK). We now report cloning and characterization of the ltm biosynthetic gene cluster from Streptomyces amphibiosporus ATCC 53964, which consists of nine genes that encode an AT-less type I PKS (LtmBCDEFGHL) and one tailoring enzyme (LtmK). Inactivation of ltmE or ltmH afforded the mutant strain SB15001 or SB15002, respectively, that abolished the production of 1, as well as the three cometabolites 8,9-dihydro-LTM (14), 8,9-dihydro-8S-hydroxy-LTM (15), and 8,9-dihydro-9R-hydroxy-LTM (13). Inactivation of ltmK yielded the mutant strain SB15003 that abolished the production of 1, 13, and 15 but led to the accumulation of 14. Complementation of the ΔltmK mutation in SB15003 by expressing ltmK in trans restored the production of 1, as well as that of 13 and 15. These results support the model for 1 biosynthesis, featuring an AT-less type I PKS that synthesizes 14 as the nascent polyketide intermediate and a cytochrome P450 desaturase that converts 14 to 1, with 13 and 15 as minor cometabolites. Comparative analysis of the LTM and iso-MGS AT-less type I PKSs revealed several unusual features that deviate from those of the collinear type I PKS model. Exploitation of the tailoring enzymes for 1 and 2 biosynthesis afforded two analogues, 8,9-dihydro-8R-hydroxy-LTM (16) and 8,9-dihydro-8R-methoxy-LTM (17), that provided new insights into the structure–activity relationship of 1 and 2. While 12-membered macrolides, featuring a combination of a hydroxyl group at C-17 and a double bond at C-8 and C-9 as found in 1, exhibit the most potent activity, analogues with a single hydroxyl or methoxy group

  3. Derivatives of Z-bisdehydrodoisynolic acid provide a new description of the binding-activity paradox and selective estrogen receptor modulator activity.

    PubMed

    Adler, Molly; Hou, Yuqing; Sandrock, Paul; Meyers, Cal Y; Winters, Todd A; Banz, William J; Adler, Stuart

    2006-08-01

    Z-Bisdehydrodoisynolic acid [(+/-)-Z-BDDA], an estrogenic carboxylic acid, is highly active in vivo yet binds poorly to estrogen receptors (ERs). Studies of Z-BDDA and its enantiomers demonstrate therapeutic potential as selective ER modulators; however, the activity vs. binding paradox has remained. One possible explanation is that the carboxylic acid group of Z-BDDA may be modified in vivo to an ester or amide. Synthesis of these derivatives showed the relative binding affinity (RBA) of the methyl ester for ERalpha and ERbeta was increased approximately 14- and 20-fold, respectively, relative to the parent compound. Yet, this increased affinity did not result in increased reporter gene expression. In contrast, the amide showed an unexpected approximately 4-fold decrease in RBA to both ERs compared with the parent. The relationship among the RBAs of ester, acid, and amide is consistent with their predicted polarity, suggesting the carboxylic acid, and not the carboxylate of BDDA, binds to ERs. Studies at pH 6.5, 7.4, and 8.0 were consistent with a simple acid-base equilibrium model, with BDDA binding as the undissociated acid and with affinity equal to or exceeding that of estradiol, consistent with high in vivo potency. Furthermore, the alcohol BDD-OH also demonstrated high affinity and increased activity in gene expression assays. In addition to suggesting a resolution to the decades-old binding/activity paradox, these studies may provide a direction for definitive in vivo metabolic and pharmacokinetic studies and provide additional insight into the chemical and metabolic determinants of BBDA's unique tissue selectivity and selective ER modulator activities.

  4. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation.

    PubMed

    de Souza, Anjali J; Oriss, Timothy B; O'malley, Katherine J; Ray, Anuradha; Kane, Lawrence P

    2005-11-22

    Polymorphisms in TIM-1, a member of the T cell Ig and mucin (TIM) domain family, are associated with relative susceptibility to the development of T helper 2-dominated immune responses such as in allergic asthma. Recent data have also suggested that ligation of TIM-1 can augment T cell activation. We have found that the TIM-1 protein is expressed on CD4(+) T cells in vivo after intranasal immunization. Ectopic expression of TIM-1 during T cell differentiation results in a significant increase in the number of cells producing IL-4 but not IFN-gamma. Furthermore, TIM-1 expression provides a costimulatory signal that increases transcription from the IL-4 promoter and from isolated nuclear factor of activated T cells/activating protein-1 (NFAT/AP-1) elements. Finally, we provide evidence that TIM-1 can be phosphorylated on tyrosine and that TIM-1 costimulation requires its cytoplasmic tail and the conserved tyrosine within that domain. These results constitute evidence that TIM-1 directly couples to phosphotyrosine-dependent intracellular signaling pathways.

  5. Plutonium and Uranium Atom Ratios and Activity Levels in Cochiti Lake Bottom Sediments Provided by Pueblo de Cochiti

    SciTech Connect

    Gallaher, B.M.; Efurd, D.W.; Rokop, D.J.; Benjamin, T.M.

    1999-05-01

    Historical operations at the Los Alamos National Laboratory have contaminated stream sediments with plutonium and other radionuclides. A small portion of these contaminated sediments has been carried by floods into the Rio Grande drainage system, eventually to be trapped by Cochiti Lake located on Pueblo de Cochiti lands approximately 8 km downstream of the Laboratory. In this study, lake bottom sediment samples provided by the Pueblo de Cochiti were analyzed by thermal ionization mass spectrometry to determine plutonium and uranium activity levels and isotopic atom ratios. This specialized analytical method allows us to take isotopic fingerprints of radionuclides found in the sediment and to determine how much plutonium and uranium came from the Laboratory and how much was deposited by worldwide fallout or is natural. Two distinct types of samples were processed: segments of a continuous vertical core of the entire accumulated sediment sequence and other samples from across the lake bottom at the water/sediment interface. Based on measurement of the {sup 240}Pu/{sup 239}Pu atom ratio, Laboratory-derived plutonium is present in eight of nine samples at the core site. On a depth-weighted basis, approximately one-half of the {sup 239}Pu and {sup 240}Pu came from early operations at the Laboratory; the remaining plutonium came from fallout dispersed by above-ground nuclear tests. In contrast to the core site, the samples from the other locations showed little or no evidence of Laboratory-derived plutonium, with more than 90 percent of the plutonium attributable to fallout. The overall amount of plutonium in all the samples is of the same magnitude as other reservoirs in the region. The net increase in plutonium over upstream reservoirs unaffected by Laboratory activities is a maximum of 0.014 pCi/g or 3.5 times. All of the samples reflect natural uranium compositions. Laboratory-derived uranium is not identifiable, presumably because the sediment contains abundant

  6. Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo.

    PubMed Central

    Burz, D S; Rivera-Pomar, R; Jäckle, H; Hanes, S D

    1998-01-01

    The Bicoid morphogen directs pattern formation along the anterior-posterior (A-P) axis of the Drosophila embryo. Bicoid is distributed in a concentration gradient that decreases exponentially from the anterior pole, however, it transcribes target genes such as hunchback in a step-function-like pattern; the expression domain is uniform and has a sharply defined posterior boundary. A 'gradient-affinity' model proposed to explain Bicoid action states that (i) cooperative gene activation by Bicoid generates the sharp on/off switch for target gene transcription and (ii) target genes with different affinities for Bicoid are expressed at different positions along the A-P axis. Using an in vivo yeast assay and in vitro methods, we show that Bicoid binds DNA with pairwise cooperativity; Bicoid bound to a strong site helps Bicoid bind to a weak site. These results support the first aspect of the model, providing a mechanism by which Bicoid generates sharp boundaries of gene expression. However, contrary to the second aspect of the model, we find no significant difference between the affinity of Bicoid for the anterior gene hunchback and the posterior gene knirps. We propose, instead, that the arrangement of Bicoids bound to the target gene presents a unique signature to the transcription machinery that, in combination with overall affinity, regulates the extent of gene transcription along the A-P axis. PMID:9774343

  7. Active fiber-based retroreflector providing phase-retracing anti-parallel laser beams for precision spectroscopy.

    PubMed

    Beyer, A; Maisenbacher, L; Matveev, A; Pohl, R; Khabarova, K; Chang, Y; Grinin, A; Lamour, T; Shi, T; Yost, D C; Udem, Th; Hänsch, T W; Kolachevsky, N

    2016-07-25

    We present an active fiber-based retroreflector providing high quality phase-retracing anti-parallel Gaussian laser beams for precision spectroscopy of Doppler sensitive transitions. Our design is well-suited for a number of applications where implementing optical cavities is technically challenging and corner cubes fail to match the demanded requirements, most importantly retracing wavefronts and preservation of the laser polarization. To illustrate the performance of the system, we use it for spectroscopy of the 2S-4P transition in atomic hydrogen and demonstrate an average suppression of the first order Doppler shift to 4 parts in 106 of the full collinear shift. This high degree of cancellation combined with our cryogenic source of hydrogen atoms in the metastable 2S state is sufficient to enable determinations of the Rydberg constant and the proton charge radius with competitive uncertainties. Advantages over the usual Doppler cancellation based on corner cube type retroreflectors are discussed as well as an alternative method using a high finesse cavity. PMID:27464193

  8. One RNA plays three roles to provide catalytic activity to a group I intron lacking an endogenous internal guide sequence.

    PubMed

    Vaidya, Nilesh; Lehman, Niles

    2009-07-01

    Catalytic RNA molecules possess simultaneously a genotype and a phenotype. However, a single RNA genotype has the potential to adopt two or perhaps more distinct phenotypes as a result of differential folding and/or catalytic activity. Such multifunctionality would be particularly significant if the phenotypes were functionally inter-related in a common biochemical pathway. Here, this phenomenon is demonstrated by the ability of the Azoarcus group I ribozyme to function when its canonical internal guide sequence (GUG) has been removed from the 5' end of the molecule, and added back exogenously in trans. The presence of GUG triplets in non-covalent fragments of the ribozyme allow trans-splicing to occur in both a reverse splicing assay and a covalent self-assembly assay in which the internal guide sequence (IGS)-less ribozyme can put itself together from two of its component pieces. Analysis of these reactions indicates that a single RNA fragment can perform up to three distinct roles in a reaction: behaving as a portion of a catalyst, behaving as a substrate, and providing an exogenous IGS. This property of RNA to be multifunctional in a single reaction pathway bolsters the probability that a system of self-replicating molecules could have existed in an RNA world during the origins of life on the Earth. PMID:19406926

  9. Help-Seeking Behaviors Among Active-Duty Military Personnel: Utilization of Chaplains and Other Mental Health Service Providers

    PubMed Central

    Morgan, Jessica Kelley; Hourani, Laurel; Lane, Marian E.; Tueller, Stephen

    2016-01-01

    Military chaplains not only conduct religious services, but also provide counseling and spiritual support to military service members, operating as liaisons between soldiers and mental health professionals. In this study, active-duty soldiers (N = 889) reported help-seeking behaviors and mental health. Using logistic regressions, we describe the issues for which soldiers reported seeking help, then outline the characteristics of those who are most likely to seek help from a chaplain. Of the soldiers who sought help from a chaplain within the previous year, 29.9% reported high levels of combat exposure, 50.8% screened positive for depression, 39.1% had probable PTSD, and 26.6% screened positive for generalized anxiety disorder. The participant’s unit firing on the enemy, personally firing on the enemy, and seeing dead bodies or human remains predicted seeing a chaplain. Future research should examine ways to engage soldiers who have had more combat experiences with the chaplain community to address spiritual issues. PMID:27191375

  10. Essays on Character & Opportunity

    ERIC Educational Resources Information Center

    Center on Children and Families at Brookings, 2014

    2014-01-01

    These essays provide richer set of writings on the philosophical, empirical and practical issues raised by a focus on character, and in particular its relationship to questions of opportunity. Each one is an intellectual pemmican: sharp and to the point. Two scholars draw attention to the gendered nature of character formation (Segal and Lexmond);…

  11. Wisconsin Education Opportunity Program.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison. Div. for School Financial Resources and Management Services.

    This report describes the history and programs of the Wisconsin Education Opportunity Program (WEOP), a bureau within the State Department of Public Instruction that provides support services for Wisconsin youths and adults (particularly the disadvantaged) who intend to complete a postsecondary education program. Currently, it is said, WEOP…

  12. Strategic opportunities

    SciTech Connect

    Gottlieb, J.W.

    1994-09-01

    Despite statements of doom and gloom from numerous industry pundits, the potential for global hydropower development opportunities remains vast. Statistics demonstrating the potential for hydroelectric development in the United States alone are staggering. More than 80,000 dams exist in the United States, yet only 3 percent have been developed to tap their hydroelectric potential. There is currently about 70,800 MW of installed hydroelectric capacity, with more than 76,000 MW of undeveloped potential. It has been estimated that there are about 3,000 abandoned hydropower sites in the United States. Less than 200 of these sites have been redeveloped. The United States Department of Energy (DOE) has estimated redevelopment and rehabilitation of hydropower electric sites in the United States could add an additional 14,000 MW of potential.

  13. 36 CFR 218.23 - Proposed projects and activities not subject to legal notice and opportunity to comment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... process set out in 36 CFR part 219, subpart B; (c) Proposed plan amendments associated with a project or... projects and activities (see 36 CFR 219.59(b)); (d) Proposed projects and activities not subject to the provisions of the National Environmental Policy Act and the implementing regulations at 40 CFR parts...

  14. 36 CFR 218.23 - Proposed projects and activities not subject to legal notice and opportunity to comment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... process set out in 36 CFR part 219, subpart B; (c) Proposed plan amendments associated with a project or... projects and activities (see 36 CFR 219.59(b)); (d) Proposed projects and activities not subject to the provisions of the National Environmental Policy Act and the implementing regulations at 40 CFR parts...

  15. Opportunities for Youth: Culture Design for an Unknown Culture.

    ERIC Educational Resources Information Center

    Clement, W. R.

    In the summer of 1971, the Canadian federal government initiated a major youth program known as Opportunities for Youth (OFY). The program ostensibly provided summer jobs and activities for students. The contract designer reports on program design, activities, and implications for government and education. The designer's interest was an analysis…

  16. The influence of providing perches and string on activity levels, fearfulness and leg health in commercial broiler chickens.

    PubMed

    Bailie, C L; O'Connell, N E

    2015-04-01

    The aim of this study was to assess the effect of providing environmental enrichment in the form of perches and string on the behaviour and welfare of commercial broiler chickens. Houses containing ~23 000 broiler chickens were assigned to one of four treatments in a 2×2 factorial design. Treatments involved two levels of access to perches (P) (present (24/house) '+P' or absent '-P') and two levels of access to string (S) (present (24/house) '+S' or absent '-S'). All houses contained windows, and 30 straw bales were provided from day 10 of the rearing cycle. Treatments were applied in one of four houses on a single farm, and were replicated over four production cycles. Behaviour and leg health were observed in weeks 3 to 5 of the rearing cycle. Production performance and environmental parameters were also measured. There was an interaction between perches and age in the percentage of birds observed lying, with higher percentages of birds observed lying in the +P treatment than in the -P treatment during weeks 4 and 5. There was also a significant interaction between string and age in the percentage of birds observed in locomotion, with higher percentages observed in locomotion in the -S treatment than in the +S treatment during weeks 4 and 5. There was also an interaction between string and age in average gait scores, with lower gait scores in the +S treatment than in the -S treatment during weeks 3 and 5 but not within week 4. Daytime observations showed that perches and strings were used frequently, with one bout of perching occurring approximately every 80 s/perch, and one bout of pecking at string occurring every 78 s/string on average. There was a significant effect of age on use of perches (P<0.001) and string (P<0.001), with perching peaking during week 5 and string pecking peaking during week 3. We conclude that commercial broilers in windowed houses with access to straw bales display an interest in additional enrichment stimuli in the form of perches and

  17. The influence of providing perches and string on activity levels, fearfulness and leg health in commercial broiler chickens.

    PubMed

    Bailie, C L; O'Connell, N E

    2015-04-01

    The aim of this study was to assess the effect of providing environmental enrichment in the form of perches and string on the behaviour and welfare of commercial broiler chickens. Houses containing ~23 000 broiler chickens were assigned to one of four treatments in a 2×2 factorial design. Treatments involved two levels of access to perches (P) (present (24/house) '+P' or absent '-P') and two levels of access to string (S) (present (24/house) '+S' or absent '-S'). All houses contained windows, and 30 straw bales were provided from day 10 of the rearing cycle. Treatments were applied in one of four houses on a single farm, and were replicated over four production cycles. Behaviour and leg health were observed in weeks 3 to 5 of the rearing cycle. Production performance and environmental parameters were also measured. There was an interaction between perches and age in the percentage of birds observed lying, with higher percentages of birds observed lying in the +P treatment than in the -P treatment during weeks 4 and 5. There was also a significant interaction between string and age in the percentage of birds observed in locomotion, with higher percentages observed in locomotion in the -S treatment than in the +S treatment during weeks 4 and 5. There was also an interaction between string and age in average gait scores, with lower gait scores in the +S treatment than in the -S treatment during weeks 3 and 5 but not within week 4. Daytime observations showed that perches and strings were used frequently, with one bout of perching occurring approximately every 80 s/perch, and one bout of pecking at string occurring every 78 s/string on average. There was a significant effect of age on use of perches (P<0.001) and string (P<0.001), with perching peaking during week 5 and string pecking peaking during week 3. We conclude that commercial broilers in windowed houses with access to straw bales display an interest in additional enrichment stimuli in the form of perches and

  18. The Feasibility of Using Nature-Based Settings for Physical Activity Programming: Views from Urban Youth and Program Providers

    ERIC Educational Resources Information Center

    Blanton, Jedediah E.; Oregon, Evelyn M.; Flett, M. Ryan; Gould, Daniel R.; Pfeiffer, Karin A.

    2013-01-01

    Background and Purpose: Given the urgency to design programs to increase physical activity, especially to combat obesity in children, the primary purpose of this study was to investigate perceptions and opinions of a nature-based physical activity intervention designed for low-income urban adolescents. Methods: Four focus groups of adolescents,…

  19. Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential Activation.

    PubMed

    Shir-Shapira, Hila; Sharabany, Julia; Filderman, Matan; Ideses, Diana; Ovadia-Shochat, Avital; Mannervik, Mattias; Juven-Gershon, Tamar

    2015-07-10

    Regulation of RNA polymerase II transcription is critical for the proper development, differentiation, and growth of an organism. The RNA polymerase II core promoter is the ultimate target of a multitude of transcription factors that control transcription initiation. Core promoters encompass the RNA start site and consist of functional elements such as the TATA box, initiator, and downstream core promoter element (DPE), which confer specific properties to the core promoter. We have previously discovered that Drosophila Caudal, which is a master regulator of genes involved in development and differentiation, is a DPE-specific transcriptional activator. Here, we show that the mouse Caudal-related homeobox (Cdx) proteins (mCdx1, mCdx2, and mCdx4) are also preferential core promoter transcriptional activators. To elucidate the mechanism that enables Caudal to preferentially activate DPE transcription, we performed structure-function analysis. Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz) Caudal target gene. Furthermore, the region containing both the homeodomain and the C terminus of Caudal was sufficient to confer core promoter-preferential activation to the heterologous GAL4 DNA-binding domain. Importantly, we discovered that Drosophila CREB-binding protein (dCBP) is a co-activator for Caudal-regulated activation of ftz. Strikingly, dCBP conferred the ability to preferentially activate the DPE-dependent ftz reporter to mini-Caudal proteins that were unable to preferentially activate ftz transcription themselves. Taken together, it is the unique combination of dCBP and Caudal that enables the co-activation of ftz in a core promoter-preferential manner.

  20. Ecological opportunity and the adaptive diversification of lineages

    PubMed Central

    Wellborn, Gary A; Langerhans, R Brian

    2015-01-01

    The tenet that ecological opportunity drives adaptive diversification has been central to theories of speciation since Darwin, yet no widely accepted definition or mechanistic framework for the concept currently exists. We propose a definition for ecological opportunity that provides an explicit mechanism for its action. In our formulation, ecological opportunity refers to environmental conditions that both permit the persistence of a lineage within a community, as well as generate divergent natural selection within that lineage. Thus, ecological opportunity arises from two fundamental elements: (1) niche availability, the ability of a population with a phenotype previously absent from a community to persist within that community and (2) niche discordance, the diversifying selection generated by the adaptive mismatch between a population's niche-related traits and the newly encountered ecological conditions. Evolutionary response to ecological opportunity is primarily governed by (1) spatiotemporal structure of ecological opportunity, which influences dynamics of selection and development of reproductive isolation and (2) diversification potential, the biological properties of a lineage that determine its capacity to diversify. Diversification under ecological opportunity proceeds as an increase in niche breadth, development of intraspecific ecotypes, speciation, and additional cycles of diversification that may themselves be triggered by speciation. Extensive ecological opportunity may exist in depauperate communities, but it is unclear whether ecological opportunity abates in species-rich communities. Because ecological opportunity should generally increase during times of rapid and multifarious environmental change, human activities may currently be generating elevated ecological opportunity – but so far little work has directly addressed this topic. Our framework highlights the need for greater synthesis of community ecology and evolutionary biology, unifying

  1. Convergence Creates Opportunities Across Health Care System

    PubMed Central

    Fox, Brent I.; Felkey, Bill G.

    2014-01-01

    Industrial design students at Auburn do a creativity exercise where they are asked to combine a common household appliance with an animal. Have you seen a snake light? In health technology, we have a similar opportunity. In the connection between jewelry and vital sign monitoring technology or household security and health status monitoring, we are witnessing active convergence that will benefit patients, providers, and health systems. PMID:24958948

  2. Convergence creates opportunities across health care system.

    PubMed

    Fox, Brent I; Felkey, Bill G

    2014-04-01

    Industrial design students at Auburn do a creativity exercise where they are asked to combine a common household appliance with an animal. Have you seen a snake light? In health technology, we have a similar opportunity. In the connection between jewelry and vital sign monitoring technology or household security and health status monitoring, we are witnessing active convergence that will benefit patients, providers, and health systems.

  3. Convergence creates opportunities across health care system.

    PubMed

    Fox, Brent I; Felkey, Bill G

    2014-04-01

    Industrial design students at Auburn do a creativity exercise where they are asked to combine a common household appliance with an animal. Have you seen a snake light? In health technology, we have a similar opportunity. In the connection between jewelry and vital sign monitoring technology or household security and health status monitoring, we are witnessing active convergence that will benefit patients, providers, and health systems. PMID:24958948

  4. Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.

    PubMed

    Makarev, Evgeny; Cantor, Charles; Zhavoronkov, Alex; Buzdin, Anton; Aliper, Alexander; Csoka, Anotonei Benjamin

    2014-12-01

    Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, "AMD Medicine", and discovered differential pathway activation profiles in samples of human RPE/choroid from AMD patients and controls. We identified 29 pathways in RPE-choroid AMD phenotypes: 27 pathways were activated in AMD compared to controls, and 2 pathways were activated in controls compared to AMD. In AMD, we identified a graded activation of pathways related to wound response, complement cascade, and cell survival. Also, there was downregulation of two pathways responsible for apoptosis. Furthermore, significant activation of pro-mitotic pathways is consistent with dedifferentiation and cell proliferation events, which occur early in the pathogenesis of AMD. Significantly, we discovered new global pathway activation signatures of AMD involved in the cell-based inflammatory response: IL-2, STAT3, and ERK. The ultimate aim of our research is to achieve a better understanding of signaling pathways involved in AMD pathology, which will eventually lead to better treatments. PMID:25543336

  5. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

    PubMed Central

    Martínez-Barricarte, Rubén; Heurich, Meike; Valdes-Cañedo, Francisco; Vazquez-Martul, Eduardo; Torreira, Eva; Montes, Tamara; Tortajada, Agustín; Pinto, Sheila; Lopez-Trascasa, Margarita; Morgan, B. Paul; Llorca, Oscar; Harris, Claire L.; Rodríguez de Córdoba, Santiago

    2010-01-01

    Dense deposit disease (DDD) is a severe renal disease characterized by accumulation of electron-dense material in the mesangium and glomerular basement membrane. Previously, DDD has been associated with deficiency of factor H (fH), a plasma regulator of the alternative pathway (AP) of complement activation, and studies in animal models have linked pathogenesis to the massive complement factor 3 (C3) activation caused by this deficiency. Here, we identified a unique DDD pedigree that associates disease with a mutation in the C3 gene. Mutant C3923ΔDG, which lacks 2 amino acids, could not be cleaved to C3b by the AP C3-convertase and was therefore the predominant circulating C3 protein in the patients. However, upon activation to C3b by proteases, or to C3(H2O) by spontaneous thioester hydrolysis, C3923ΔDG generated an active AP C3-convertase that was regulated normally by decay accelerating factor (DAF) but was resistant to decay by fH. Moreover, activated C3b923ΔDG and C3(H2O)923ΔDG were resistant to proteolysis by factor I (fI) in the presence of fH, but were efficiently inactivated in the presence of membrane cofactor protein (MCP). These characteristics cause a fluid phase–restricted AP dysregulation in the patients that continuously activated and consumed C3 produced by the normal C3 allele. These findings expose structural requirements in C3 that are critical for recognition of the substrate C3 by the AP C3-convertase and for the regulatory activities of fH, DAF, and MCP, all of which have implications for therapeutic developments. PMID:20852386

  6. Overview of energy-conservation research opportunities

    SciTech Connect

    Hopp, W.J.; Hauser, S.G.; Hane, G.J.; Gurwell, W.E.; Bird, S.P.; Cliff, W.C.; Williford, R.E.; Williams, T.A.; Ashton, W.B.

    1981-12-01

    This document is a study of research opportunities that are important to developing advanced technologies for efficient energy use. The study's purpose is to describe a wide array of attractive technical areas from which specific research and development programs could be implemented. Research areas are presented for potential application in each of the major end-use sectors. The study develops and applies a systematic approach to identifying and screening applied energy conservation research opportunities. To broadly cover the energy end-use sectors, this study develops useful information relating to the areas where federally-funded applied research will most likely play an important role in promoting energy conservation. This study is not designed to produce a detailed agenda of specific recommended research activities. The general information presented allows uniform comparisons of disparate research areas and as such provides the basis for formulating a cost-effective, comprehensive federal-applied energy conservation research strategy. Chapter 2 discusses the various methodologies that have been used in the past to identify research opportunities and details the approach used here. In Chapters 3, 4, and 5 the methodology is applied to the buildings, transportation, and industrial end-use sectors and the opportunities for applied research in these sectors are discussed.Chapter 6 synthesizes the results of the previous three chapters to give a comprehensive picture of applied energy conservation research opportunities across all end-use sectors and presents the conclusions to the report.

  7. 20 CFR 665.300 - What are rapid response activities and who is responsible for providing them?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... natural or other disaster resulting in a mass job dislocation. (b) The State is responsible for providing... substantially increase the number of unemployed individuals. (c) States must establish a rapid...

  8. Young Children's Engagement and Learning Opportunities in a Cooking Activity with Parents and Older Siblings

    ERIC Educational Resources Information Center

    Finn, Lauren; Vandermaas-Peeler, Maureen

    2013-01-01

    Parents teach their children through informal social interactions in a process known as guided participation (Rogoff, 1990). Although most research focuses on parent-child dyads, young children also learn from older siblings and parents through shared participation in daily activities. Utilizing a structured observational design, the authors…

  9. Land of the Rising Pulse: A Social Ecological Perspective of Physical Activity Opportunities for Schoolchildren in Japan

    ERIC Educational Resources Information Center

    Webster, Collin Andrew; Suzuki, Naoki

    2014-01-01

    The uptake of policies and recommendations to promote physical activity (PA) in American schools has been slow. It can be useful to investigate international contexts where school-based PA promotion has had more success and consider whether facilitative factors have transferability to American schools. This study employed a social ecological…

  10. 75 FR 9431 - Small and Medium-Sized Enterprises: U.S. and EU Export Activities, and Barriers and Opportunities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... October 28, 2009 (74 FR 55581); December 1, 2009 (74 FR 62812); and December 11, 2009 (74 FR 65787). A... the Federal Register of February 4, 2010 (75 FR 5804). Washington Hearing: The rescheduled Washington... Government activity was cancelled due to a snow storm. Persons wishing to appear at the March 18...

  11. Idaho Robotics Opportunities for K-12 Students: A K-12 Pipeline of Activities Promoting Careers in Science, Engineering, and Technology

    ERIC Educational Resources Information Center

    Ewers, Timothy G.

    2010-01-01

    4-H youth development programs nationwide are responding to the 4-H National Science, Engineering, and Technology (4-H SET) Initiative to involve more youth in Science, Engineering, and Technology activities. The goal is to increase the numbers of youth choosing to pursue SET careers. This article describes a program that is having great success…

  12. Contractor report to the Department of Energy on opportunities for integration of environmental management activities across the complex (predecisional draft). Revision 1

    SciTech Connect

    1997-03-01

    The US Department of Energy (DOE) Environmental Management (EM) program faces significant technical and financial challenges in cleaning up the environmental legacy of nuclear weapons production and research and development, while facing an uncertain future in obtaining the needed funding to perform this work. Many of these requirements, including State and Federal regulations and negotiated agreements, continue to be a significant contributor to EM program costs and schedules. Historically, the sites have managed their programs focusing on their individual site`s needs. While this approach maximized successes at individual sites, it has resulted in a more costly program than if more integration across the DOE system occurred. In July 1996, the DOE Assistant Secretary for EM, Al Alm, chartered a contractor led effort to perform complex-wide integration in support of the ten-year plan process to develop a suite of technically defensible, integrated alternatives to meet the EM mission. This report documents opportunities for waste and nuclear materials management integration activities in six areas: transuranic (TRU) waste, mixed low-level waste (MLLW), low-level waste (LLW), environmental restoration (ER), high-level waste (HLW), and spent nuclear fuel (SNF). The opportunities represent technically defensible solutions which reduce cost, accelerate schedules, and result in no significant increase in risk.

  13. 20 CFR 669.680 - What activities and services may be provided under the MSFW youth program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under the MSFW youth program? 669.680 Section 669.680 Employees' Benefits EMPLOYMENT AND TRAINING... youth program? (a) Based on an evaluation and assessment of the needs of MSFW youth participants... training services, as described in §§ 669.400 and 669.410; (2) Life skills activities which may...

  14. Induction of lcc2 expression and activity by Agaricus bisporus provides defence against Trichoderma aggressivum toxic extracts

    PubMed Central

    Sjaarda, Calvin P; Abubaker, Kamal S; Castle, Alan J

    2015-01-01

    Laccases are used by fungi for several functions including defence responses to stresses associated with attack by other fungi. Laccase activity changes and the induction of two laccase genes, lcc1 and lcc2, in Agaricus bisporus were measured in response to toxic extracts of medium in which Trichoderma aggressivum, the cause of green mould disease, was grown. A strain of A. bisporus that shows resistance to the extracts showed higher basal levels and greater enzymatic activity after extract exposure than did a sensitive strain. Furthermore, pre-incubation of T. aggressivum extract with laccases reduced toxicity. Faster induction and greater numbers of lcc2 transcripts in response to the extract were noted in the resistant strain than in the sensitive strain. The timing and increase in lcc2 transcript abundance mirrored changes in total laccase activity. No correlation between resistance and lcc1 transcription was apparent. Transcript abundance in transformants with a siRNA construct homologous to both genes varied widely. A strong negative correlation between transcript abundance and sensitivity of the transformant to toxic extract was observed in plate assays. These results indicated that laccase activity and in particular that encoded by lcc2 contributes to toxin metabolism and by extension green mould disease resistance. PMID:25824278

  15. Induction of lcc2 expression and activity by Agaricus bisporus provides defence against Trichoderma aggressivum toxic extracts.

    PubMed

    Sjaarda, Calvin P; Abubaker, Kamal S; Castle, Alan J

    2015-11-01

    Laccases are used by fungi for several functions including defence responses to stresses associated with attack by other fungi. Laccase activity changes and the induction of two laccase genes, lcc1 and lcc2, in Agaricus bisporus were measured in response to toxic extracts of medium in which Trichoderma aggressivum, the cause of green mould disease, was grown. A strain of A. bisporus that shows resistance to the extracts showed higher basal levels and greater enzymatic activity after extract exposure than did a sensitive strain. Furthermore, pre-incubation of T. aggressivum extract with laccases reduced toxicity. Faster induction and greater numbers of lcc2 transcripts in response to the extract were noted in the resistant strain than in the sensitive strain. The timing and increase in lcc2 transcript abundance mirrored changes in total laccase activity. No correlation between resistance and lcc1 transcription was apparent. Transcript abundance in transformants with a siRNA construct homologous to both genes varied widely. A strong negative correlation between transcript abundance and sensitivity of the transformant to toxic extract was observed in plate assays. These results indicated that laccase activity and in particular that encoded by lcc2 contributes to toxin metabolism and by extension green mould disease resistance.

  16. The soil moisture active/passive (SMAP) mission: How we got here and what it will provide

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil Moisture Active Passive (SMAP) satellite will be launched by the National Aeronautics and Space Administration in October 2014. This satellite is the culmination of basic research and applications development over the past thirty years. During most of this period, research and development o...

  17. Domain organization of DNase from Thioalkalivibrio sp. provides insights into retention of activity in high salt environments.

    PubMed

    Alzbutas, Gediminas; Kaniusaite, Milda; Grybauskas, Algirdas; Lagunavicius, Arunas

    2015-01-01

    Our study indicates that DNA binding domains are common in many halophilic or halotolerant bacterial DNases and they are potential activators of enzymatic activity at high ionic strength. Usually, proteins adapt to high ionic strength by increasing the number of negatively charged residues on the surface. However, in DNases such adaptation would hinder the binding to negatively charged DNA, a step critical for catalysis. In our study we demonstrate how evolution has solved this dilemma by engaging the DNA binding domain. We propose a mechanism, which enables the enzyme activity at salt concentrations as high as 4 M of sodium chloride, based on collected experimental data and domain structure analysis of a secreted bacterial DNase from the extremely halotolerant bacterium Thioalkalivibrio sp. K90mix. The enzyme harbors two domains: an N-terminal domain, that exhibits DNase activity, and a C-terminal domain, comprising a duplicate DNA binding helix-hairpin-helix motif. Here we present experimental data demonstrating that the C-terminal domain is responsible for the enzyme's resistance to high ionic strength. PMID:26191053

  18. Physical Activity for Young Children: A Quantitative Study of Child Care Providers' Knowledge, Attitudes, and Health Promotion Practices

    ERIC Educational Resources Information Center

    Lanigan, Jane

    2014-01-01

    Many preschool children fail to achieve the National Association for Sport and Physical Education physical activity recommendations placing themselves at increased risk of overweight and its associated health consequences. The early learning and care system is well positioned to intervene. Yet few child obesity prevention efforts have focused on…

  19. Activities of Secreted Aryl Alcohol Quinone Oxidoreductases from Pycnoporus cinnabarinus Provide Insights into Fungal Degradation of Plant Biomass

    PubMed Central

    Piumi, Francois; Valli, Richard; Aramburu, Juan Carro; Ferreira, Patricia; Faulds, Craig B.; Record, Eric

    2016-01-01

    Auxiliary activities family 3 subfamily 2 (AA3_2) from the CAZy database comprises various functions related to ligninolytic enzymes, such as fungal aryl alcohol oxidases (AAO) and glucose oxidases, both of which are flavoenzymes. The recent study of the Pycnoporus cinnabarinus CIRM BRFM 137 genome combined with its secretome revealed that four AA3_2 enzymes are secreted during biomass degradation. One of these AA3_2 enzymes, scf184803.g17, has recently been produced heterologously in Aspergillus niger. Based on the enzyme's activity and specificity, it was assigned to the glucose dehydrogenases (P. cinnabarinus GDH [PcGDH]). Here, we analyze the distribution of the other three AA3_2 enzymes (scf185002.g8, scf184611.g7, and scf184746.g13) to assess their putative functions. These proteins showed the highest homology with aryl alcohol oxidase from Pleurotus eryngii. Biochemical characterization demonstrated that they were also flavoenzymes harboring flavin adenine dinucleotide (FAD) as a cofactor and able to oxidize a wide variety of phenolic and nonphenolic aryl alcohols and one aliphatic polyunsaturated primary alcohol. Though presenting homology with fungal AAOs, these enzymes exhibited greater efficiency in reducing electron acceptors (quinones and one artificial acceptor) than molecular oxygen and so were defined as aryl-alcohol:quinone oxidoreductases (AAQOs) with two enzymes possessing residual oxidase activity (PcAAQO2 and PcAAQO3). Structural comparison of PcAAQO homology models with P. eryngii AAO demonstrated a wider substrate access channel connecting the active-site cavity to the solvent, explaining the absence of activity with molecular oxygen. Finally, the ability of PcAAQOs to reduce radical intermediates generated by laccase from P. cinnabarinus was demonstrated, shedding light on the ligninolytic system of this fungus. PMID:26873317

  20. Very small "window of opportunity" for generating CO oxidation-active Au(n) on TiO2.

    PubMed

    Tang, X; Schneider, J; Dollinger, A; Luo, Y; Wörz, A S; Judai, K; Abbet, S; Kim, Y D; Ganteför, G F; Fairbrother, D H; Heiz, U; Bowen, K H; Proch, S

    2014-04-14

    Recent research in heterogeneous catalysis, especially on size-selected model systems under UHV conditions and also in realistic catalytic environments, has proved that it is necessary to think in terms of the exact number of atoms when it comes to catalyst design. This is of utmost importance if the amount of noble metal, gold in particular, is to be reduced for practical reactions like CO oxidation. Here it is shown that on TiO2 only Au6 and Au7 clusters are active for CO oxidation which holds for the single crystal, thin films, and titania clusters deposited on HOPG. Size-selected cluster deposition and TPD methods have been employed to investigate the CO oxidation activity of Aun/TiO2 systems which are compared to recent results reported by Lee et al. to form a consistent picture in which only two species can be regarded as "active". The efficiency of investigated Aun/(TiO2)93/HOPG composite materials is attributed to carbon-assisted oxygen spillover from gold to support particles and across grain boundaries.

  1. Revealing the Whiteboard to Blind Students: An Inclusive Approach to Provide Mediation in Synchronous E-Learning Activities

    ERIC Educational Resources Information Center

    Freire, Andre P.; Linhalis, Flavia; Bianchini, Sandro L.; Fortes, Renata P. M.; Pimentel, Maria de Graca C.

    2010-01-01

    Promoting the inclusion of students with disabilities in e-learning systems has brought many challenges for researchers and educators. The use of synchronous communication tools such as interactive whiteboards has been regarded as an obstacle for inclusive education. In this paper, we present the proposal of an inclusive approach to provide blind…

  2. The Role of Security Concerns in Determining Information Systems/Technology Activities Outsourced to Offshore Service Providers in India

    ERIC Educational Resources Information Center

    Ocholi, Smart

    2012-01-01

    Based on research studies, the Information System/Technology (IS/T) outsourcing industry in India is reasoned to maintain the status quo of providing IS/T services at the lower level of the IS/T value chain. The 2006 study conducted by Walsh supported the 2001 findings by Arora, Arunachalam, Asundi, and Fernandes that India-based IS /T service…

  3. 77 FR 5039 - Accommodation Service Provided on Vessels Engaged in U.S. Outer Continental Shelf Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Act notice regarding our public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). II. Background A. General The offshore mineral and energy exploration and production industry... offshore. Because of this, we believe that the use of vessels providing accommodation service on the...

  4. 78 FR 48543 - Veterans Health Administration Fund Availability Under the VA's Homeless Providers Grant and Per...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ..., and plans for social engagement within the program and in the community; (3) Provide opportunities for... participants to engage in ``tasks of dying,'' or activities of ``getting things in order'' or other...

  5. Heat switches providing low-activation power and quick-switching time for use in cryogenic multi-stage refrigerators

    NASA Astrophysics Data System (ADS)

    Kimball, Mark Oliver; Shirron, P.

    2012-06-01

    An adiabatic demagnetization refrigerator (ADR) is a solid-state cooler capable of achieving sub-Kelvin temperatures. It neither requires moving parts nor a density gradient in a working fluid making it ideal for use in space-based instruments. The flow of energy through the cooler is controlled by heat switches that allow heat transfer when on and isolate portions of the cooler when off. One type of switch uses helium gas as the switching medium. In the off state the gas is adsorbed in a getter thus breaking the thermal path through the switch. To activate the switch, the getter is heated to release helium into the switch body allowing it to complete the thermal path. A getter that has a small heat capacity and low thermal conductance to the body of the switch requires low-activation power. The cooler benefits from this in two ways: shorter recycle times and higher efficiency.We describe such a design here.

  6. Activity-Dependent and Experience-Driven Myelination Provide New Directions for the Management of Multiple Sclerosis.

    PubMed

    Jensen, Samuel K; Yong, V Wee

    2016-06-01

    Despite an appreciation of the importance of myelination and the consequences of pathological demyelination, the fundamental mechanisms regulating myelination are only now being resolved. Neuronal activity has long been considered a plausible regulatory signal for myelination. However, controversy surrounding its dispensability in certain contexts and the difficulty in determining to what degree it influences myelination has limited its widespread acceptance. Recent studies have shed new light on the role of neuronal activity in regulating oligodendrogenesis and myelination. Further, the dynamics of myelin in adulthood and the association between skilled learning and myelination have become increasingly well characterized. These advances present new considerations for the management of multiple sclerosis and open up new approaches to facilitate remyelination following pathological demyelination.

  7. Structures of almond hydroxynitrile lyase isoenzyme 5 provide a rationale for the lack of oxidoreductase activity in flavin dependent HNLs.

    PubMed

    Pavkov-Keller, Tea; Bakhuis, Janny; Steinkellner, Georg; Jolink, Fenneke; Keijmel, Esther; Birner-Gruenberger, Ruth; Gruber, Karl

    2016-10-10

    Hydroxynitrile lyases (HNLs) catalyze the asymmetric addition of HCN to aldehydes producing enantiomerically pure cyanohydrins. These enzymes can be heterologously expressed in large quantities making them interesting candidates for industrial applications. The HNLs from Rosaceae evolved from flavin dependent dehydrogenase/oxidase structures. Here we report the high resolution X-ray structure of the highly glycosylated Prunus amygdalus HNL isoenzyme5 (PaHNL5 V317A) expressed in Aspergillus niger and its complex with benzyl alcohol. A comparison with the structure of isoenzyme PaHNL1 indicates a higher accessibility to the active site and a larger cavity for PaHNL5. Additionally, the PaHNL5 complex structure with benzyl alcohol was compared with the structurally related aryl-alcohol oxidase (AAO). Even though both enzymes contain an FAD-cofactor and histidine residues at crucial positions in the active site, PaHNL5 lacks the oxidoreductase activity. The structures indicate that in PaHNLs benzyl alcohol is bound too far away from the FAD cofactor in order to be oxidized. PMID:27067080

  8. Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma.

    PubMed

    Hobbie, Sven N; Kaiser, Marcel; Schmidt, Sebastian; Shcherbakov, Dmitri; Janusic, Tanja; Brun, Reto; Böttger, Erik C

    2011-05-01

    Aminoglycoside antibiotics target the ribosomal decoding A-site and are active against a broad spectrum of bacteria. These compounds bind to a highly conserved stem-loop-stem structure in helix 44 of bacterial 16S rRNA. One particular aminoglycoside, paromomycin, also shows potent antiprotozoal activity and is used for the treatment of parasitic infections, e.g. by Leishmania spp. The precise drug target is, however, unclear; in particular whether aminoglycoside antibiotics target the cytosolic and/or the mitochondrial protozoan ribosome. To establish an experimental model for the study of protozoan decoding-site function, we constructed bacterial chimeric ribosomes where the central part of bacterial 16S rRNA helix 44 has been replaced by the corresponding Leishmania and Trypanosoma rRNA sequences. Relating the results from in-vitro ribosomal assays to that of in-vivo aminoglycoside activity against Trypanosoma brucei, as assessed in cell cultures and in a mouse model of infection, we conclude that aminoglycosides affect cytosolic translation while the mitochondrial ribosome of trypanosomes is not a target for aminoglycoside antibiotics.

  9. Opportunities for Funding at DOE

    NASA Astrophysics Data System (ADS)

    Kung, Harriet

    2009-03-01

    Dr. Harriet Kung will give an overview of the fundamental materials research activities at DOE Office of Basic Energy Sciences (BES). BES supports basic research in materials sciences, chemistry, geosciences, and biosciences, as well as the construction and operation of major scientific user facilities, including the nation's large synchrotron radiation-light sources, neutron-scattering facilities, electron beam microscopy centers, and nanoscale science research centers. The objective of the materials research program at BES is to support fundamental experimental and theoretical research that provides the knowledge base for the discovery and design of new materials with novel structure, functions, and properties. The main research elements of the program are: Condensed Matter and Materials Physics, Scattering and Instrumentation Sciences, and Materials Design, Discovery, and Synthesis. Each of the three program areas has a set of central program scope and goals, while there is close coupling and connection between the three elements. For example, in the condensed matter and materials physics—including activities in experimental condensed matter physics, theoretical condensed matter physics, materials behavior and radiation effects, and physical behavior of materials—research is supported to understand, design, and control materials properties and function. The activity emphasizes correlation effects, which can lead to the formation of new particles, new phases of matter, and unexpected phenomena. The theoretical efforts focus on the development of advanced theories and computational tools to treat large or complex systems. Information about the funding opportunities will be discussed in the presentation.After the presentation, there will be an informational session for BES program managers to meet with researchers interested in research opportunities in BES. Specific information about proposal submission and proposal evaluation will be provided. For additional

  10. Symposium on Career Opportunities in Biomedical and Public Health Sciences

    NASA Technical Reports Server (NTRS)

    Sullivan, Walter W.

    1997-01-01

    The goal of the Symposium on Career Opportunities in Biomedical and Public Health Sciences is to encourage minority collegiate and junior and senior high school students to pursue careers in biomedical and public health sciences. The objectives of the Symposium are to: (1) Provide information to participants concerning biomedical and public health science careers in government, academe and industry; (2) Provide information to minority students about training activities necessary to pursue a biomedical or public health science career and the fiscal support that one can obtain for such training; and (3) Provide opportunities for participating minority biomedical and public health role models to interact with participants.

  11. The active site of hydroxynitrile lyase from Prunus amygdalus: modeling studies provide new insights into the mechanism of cyanogenesis.

    PubMed

    Dreveny, Ingrid; Kratky, Christoph; Gruber, Karl

    2002-02-01

    The FAD-dependent hydroxynitrile lyase from almond (Prunus amygdalus, PaHNL) catalyzes the cleavage of R-mandelonitrile into benzaldehyde and hydrocyanic acid. Catalysis of the reverse reaction-the enantiospecific formation of alpha-hydroxynitriles--is now widely utilized in organic syntheses as one of the few industrially relevant examples of enzyme-mediated C-C bond formation. Starting from the recently determined X-ray crystal structure, systematic docking calculations with the natural substrate were used to locate the active site of the enzyme and to identify amino acid residues involved in substrate binding and catalysis. Analysis of the modeled substrate complexes supports an enzymatic mechanism that includes the flavin cofactor as a mere "spectator" of the reaction and relies on general acid/base catalysis by the conserved His-497. Stabilization of the negative charge of the cyanide ion is accomplished by a pronounced positive electrostatic potential at the binding site. PaHNL activity requires the FAD cofactor to be bound in its oxidized form, and calculations of the pKa of enzyme-bound HCN showed that the observed inactivation upon cofactor reduction is largely caused by the reversal of the electrostatic potential within the active site. The suggested mechanism closely resembles the one proposed for the FAD-independent, and structurally unrelated HNL from Hevea brasiliensis. Although the actual amino acid residues involved in the catalytic cycle are completely different in the two enzymes, a common motif for the mechanism of cyanogenesis (general acid/base catalysis plus electrostatic stabilization of the cyanide ion) becomes evident. PMID:11790839

  12. Dynamic QTLs for sugars and enzyme activities provide an overview of genetic control of sugar metabolism during peach fruit development

    PubMed Central

    Desnoues, Elsa; Baldazzi, Valentina; Génard, Michel; Mauroux, Jehan-Baptiste; Lambert, Patrick; Confolent, Carole; Quilot-Turion, Bénédicte

    2016-01-01

    Knowledge of the genetic control of sugar metabolism is essential to enhance fruit quality and promote fruit consumption. The sugar content and composition of fruits varies with species, cultivar and stage of development, and is controlled by multiple enzymes. A QTL (quantitative trait locus) study was performed on peach fruit [Prunus persica (L.) Batsch], the model species for Prunus. Progeny derived from an interspecific cross between P. persica cultivars and P. davidiana was used. Dynamic QTLs for fresh weight, sugars, acids, and enzyme activities related to sugar metabolism were detected at different stages during fruit development. Changing effects of alleles during fruit growth were observed, including inversions close to maturity. This QTL analysis was supplemented by the identification of genes annotated on the peach genome as enzymes linked to sugar metabolism or sugar transporters. Several cases of co-locations between annotated genes, QTLs for enzyme activities and QTLs controlling metabolite concentrations were observed and discussed. These co-locations raise hypotheses regarding the functional regulation of sugar metabolism and pave the way for further analyses to enable the identification of the underlying genes. In conclusion, we identified the potential impact on fruit breeding of the modification of QTL effect close to maturity. PMID:27117339

  13. A forced damped oscillation framework for undulatory swimming provides new insights into how propulsion arises in active and passive swimming.

    PubMed

    Bhalla, Amneet Pal Singh; Griffith, Boyce E; Patankar, Neelesh A

    2013-01-01

    A fundamental issue in locomotion is to understand how muscle forcing produces apparently complex deformation kinematics leading to movement of animals like undulatory swimmers. The question of whether complicated muscle forcing is required to create the observed deformation kinematics is central to the understanding of how animals control movement. In this work, a forced damped oscillation framework is applied to a chain-link model for undulatory swimming to understand how forcing leads to deformation and movement. A unified understanding of swimming, caused by muscle contractions ("active" swimming) or by forces imparted by the surrounding fluid ("passive" swimming), is obtained. We show that the forcing triggers the first few deformation modes of the body, which in turn cause the translational motion. We show that relatively simple forcing patterns can trigger seemingly complex deformation kinematics that lead to movement. For given muscle activation, the forcing frequency relative to the natural frequency of the damped oscillator is important for the emergent deformation characteristics of the body. The proposed approach also leads to a qualitative understanding of optimal deformation kinematics for fast swimming. These results, based on a chain-link model of swimming, are confirmed by fully resolved computational fluid dynamics (CFD) simulations. Prior results from the literature on the optimal value of stiffness for maximum speed are explained. PMID:23785272

  14. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... administrative purposes under 20 CFR 667.210(a)(2). (b) Although it is not necessary to ensure that 30 percent of... of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Out-of-School Youth § 664.320 Does...

  15. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Does the requirement that at least 30 percent of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320 Section 664.320 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) YOUTH ACTIVITIES UNDER TITLE I OF...

  16. 20 CFR 664.320 - Does the requirement that at least 30 percent of youth funds be used to provide activities to out...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... administrative purposes under 20 CFR 667.210(a)(2). (b) Although it is not necessary to ensure that 30 percent of... of youth funds be used to provide activities to out-of-school youth apply to all youth funds? 664.320...) YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Out-of-School Youth § 664.320 Does...

  17. A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity.

    PubMed

    Wahba, Alexander S; Esmaeili, Abbasali; Damha, Masad J; Hudson, Robert H E

    2010-01-01

    6-Phenylpyrrolocytidine (PhpC), a structurally conservative and highly fluorescent cytidine analog, was incorporated into oligoribonucleotides. The PhpC-containing RNA formed native-like duplex structures with complementary DNA or RNA. The PhpC-modification was found to act as a sensitive reporter group being non-disruptive to structure and the enzymatic activity of RNase H. A RNA/DNA hybrid possessing a single PhpC insert was an excellent substrate for HIV-1 RT Ribonuclease H and rapidly reported cleavage of the RNA strand with a 14-fold increase in fluorescence intensity. The PhpC-based assay for RNase H was superior to the traditional molecular beacon approach in terms of responsiveness, rapidity and ease (single label versus dual). Furthermore, the PhpC-based assay is amenable to high-throughput microplate assay format and may form the basis for a new screen for inhibitors of HIV-RT RNase H.

  18. Activation of the Albino Sterlet Acipenser ruthenus Eggs by UV-Irradiated Bester Hybrid Spermatozoa to Provide Gynogenetic Progeny.

    PubMed

    Fopp-Bayat, D; Ocalewicz, K

    2015-08-01

    Meiotic gynogenesis was induced in the albino form of sterlet Acipenser ruthenus by activation of eggs with UV-irradiated bester (Huso huso x Acipenser ruthenus) spermatozoa followed by inhibition of the second meiotic division performed by a heat shock. Obtained putative gynogenetic progeny were all albinos. The genetic verification based on three microsatellite DNA markers confirmed the only maternal inheritance of the progeny from the gynogenetic experimental groups. Cytogenetic analysis proved the gynogenetic sterlets were diploids. Application of the albino phenotype together with the molecular and the cytogenetic diagnostic approaches enabled to evaluate the efficiency of the spermatozoa irradiation and application of the heat shock to restore diploid state in the gynogenetic zygotes. PMID:25858073

  19. Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

    PubMed Central

    Richardson, Andrew P.; Halestrap, Andrew P.

    2016-01-01

    Inhibition of the mitochondrial permeability transition pore (MPTP) by the novel inhibitor GNX-4975 was characterized. Titration of MPTP activity in de-energized rat liver mitochondria allowed determination of the number of GNX-4975-binding sites and their dissociation constant (Ki). Binding sites increased in number when MPTP opening was activated by increasing [Ca2+], phenylarsine oxide (PAO) or KSCN, and decreased when MPTP opening was inhibited with bongkrekic acid (BKA) or ADP. Values ranged between 9 and 50 pmol/mg of mitochondrial protein, but the Ki remained unchanged at ∼1.8 nM when the inhibitor was added before Ca2+. However, when GNX-4975 was added after Ca2+ it was much less potent with a Ki of ∼140 nM. These data imply that a protein conformational change is required to form the MPTP complex and generate the GNX-4975-binding site. Occupation of the latter with GNX-4975 prevents the Ca2+ binding that triggers pore opening. We also demonstrated that GNX-4975 stabilizes an interaction between the adenine nucleotide translocase (ANT), held in its ‘c’ conformation with carboxyatractyloside (CAT), and the phosphate carrier (PiC) bound to immobilized PAO. No components of the F1Fo-ATP synthase bound significantly to immobilized PAO. Our data are consistent with our previous proposal that the MPTP may form at an interface between the PiC and ANT (or other similar mitochondrial carrier proteins) when they adopt novel conformations induced by factors that sensitize the MPTP to [Ca2+]. We propose that GNX-4975 binds to this interface preventing a calcium-triggered event that opens the interface into a pore. PMID:26920024

  20. Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity.

    PubMed

    Richardson, Andrew P; Halestrap, Andrew P

    2016-05-01

    Inhibition of the mitochondrial permeability transition pore (MPTP) by the novel inhibitor GNX-4975 was characterized. Titration of MPTP activity in de-energized rat liver mitochondria allowed determination of the number of GNX-4975-binding sites and their dissociation constant (Ki). Binding sites increased in number when MPTP opening was activated by increasing [Ca(2+)], phenylarsine oxide (PAO) or KSCN, and decreased when MPTP opening was inhibited with bongkrekic acid (BKA) or ADP. Values ranged between 9 and 50 pmol/mg of mitochondrial protein, but the Ki remained unchanged at ∼1.8 nM when the inhibitor was added before Ca(2+) However, when GNX-4975 was added after Ca(2+) it was much less potent with a Ki of ∼140 nM. These data imply that a protein conformational change is required to form the MPTP complex and generate the GNX-4975-binding site. Occupation of the latter with GNX-4975 prevents the Ca(2+) binding that triggers pore opening. We also demonstrated that GNX-4975 stabilizes an interaction between the adenine nucleotide translocase (ANT), held in its 'c' conformation with carboxyatractyloside (CAT), and the phosphate carrier (PiC) bound to immobilized PAO. No components of the F1Fo-ATP synthase bound significantly to immobilized PAO. Our data are consistent with our previous proposal that the MPTP may form at an interface between the PiC and ANT (or other similar mitochondrial carrier proteins) when they adopt novel conformations induced by factors that sensitize the MPTP to [Ca(2+)]. We propose that GNX-4975 binds to this interface preventing a calcium-triggered event that opens the interface into a pore.

  1. [Opportunities and risks of 5α reductase inhibitors in the medical management of Active surveillance for localized prostate cancer].

    PubMed

    Linares Espinos, Estefania; Carballido Rodriguez, Joaquin

    2014-06-01

    Active surveillance (AS) as a therapeutic option is already integrated as a primary treatment strategy in low risk localized prostate cancer (PCa). There is a recent interest for the search of therapeutic interventions that result in a delay in the progression of such indolent cancers. The evaluation of the possible implication of 5 ARI drugs in the reduction of the risk of progression of PCa was enacted by the results of the clinical trials PCPT (Prostate Cancer Prevention Trial) and REDUCE (Reduction by Dutasteride of Prostate Cancer Events study). The results of the REDEEM clinical trial (Reduction by Dutasteride of clinical progression events in expectant management trial) revealed a delay in PCa progression favoring Dutasteride in comparison with placebo, being advanced age and PSA Density independent predictive factors for pathologic progression. Evidences regarding the influence of 5 ARIs in the evolution of AS patients come from few studies with limited follow up. Thus, the conclusions probably are far from being consiidered as definitive. PMID:24914845

  2. The promiscuous and synergic molecular interaction of polyphenols in bactericidal activity: an opportunity to improve the performance of antibiotics?

    PubMed

    Tomás-Menor, Laura; Barrajón-Catalán, Enrique; Segura-Carretero, Antonio; Martí, Nuria; Saura, Domingo; Menéndez, Javier A; Joven, Jorge; Micol, Vicente

    2015-03-01

    Plant polyphenols are a potential source of new antimicrobial molecules against bacteria because most newly developed antimicrobial agents do not improve the clinical management of infectious diseases. The potential synergism between the major polyphenolic compounds present in a Cistus salviifolius extract, which was characterized by HPLC-ESI-MS/MS, was investigated by the isobole method and the fractional inhibitory concentration index determination. Pairwise combinations of selected flavonoids and ellagitannins present in C. salviifolius extract were assayed against the in vitro growth of Staphylococcus aureus. Some combinations revealed synergic effects, resulting in a reduction of the minimum inhibitory concentration required to inhibit 50% growth (MIC50 ) up to 20 times lower as compared with the individual compounds. Some of the combinations exhibited MIC50 values close to drug potency level (0.5-1 µg/mL). Punicalagin and myricetin were the major contributors in the combinations. The proportion between the compounds in the synergic mixtures is crucial and may explain the superior antimicrobial activity displayed by this extract when compared with other botanical extracts. The rational optimization of these combinations could lead to the design of potent antimicrobial phytopharmaceuticals, which may improve the performance of current antibiotics, taking advantage of the multi-targeted and synergic molecular interactions of selected polyphenols.

  3. Providers issue brief: alternative providers.

    PubMed

    Rothouse, M

    1999-06-29

    Access by managed care plan enrollees, scope of practice issues and fee reimbursement by Medicaid and third parties such as insurance carriers is the engine that drives legislation recognizing alternative health care providers--chiropractors, acupuncturists, physical therapists, naturopaths, massage therapists, homeopaths, and dietitians and nutritionists. PMID:11073386

  4. Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

    PubMed Central

    Jehle, Stefan; Rajagopal, Ponni; Bardiaux, Benjamin; Markovic, Stefan; Kühne, Ronald; Stout, Joseph R; Higman, Victoria A; Klevit, Rachel E; van Rossum, Barth-Jan; Oschkinat, Hartmut

    2010-01-01

    The small heat shock protein αB-crystallin (αB) contributes to cellular protection against stress. For decades, high-resolution structural studies on oligomeric αB have been confounded by its polydisperse nature. Here, we present a structural basis of oligomer assembly and activation of the chaperone using solid-state NMR and small-angle X-ray scattering (SAXS). The basic building block is a curved dimer, with an angle of ~121° between the planes of the β-sandwich formed by α-crystallin domains. The highly conserved IXI motif covers a substrate binding site at pH 7.5. We observe a pH-dependent modulation of the interaction of the IXI motif with β4 and β8, consistent with a pH-dependent regulation of the chaperone function. N-terminal region residues Ser59-Trp60-Phe61 are involved in intermolecular interaction with β3. Intermolecular restraints from NMR and volumetric restraints from SAXS were combined to calculate a model of a 24-subunit αB oligomer with tetrahedral symmetry. PMID:20802487

  5. MRI active guidewire with an embedded temperature probe and providing a distinct tip signal to enhance clinical safety

    PubMed Central

    2012-01-01

    Background The field of interventional cardiovascular MRI is hampered by the unavailability of active guidewires that are both safe and conspicuous. Heating of conductive guidewires is difficult to predict in vivo and disruptive to measure using external probes. We describe a clinical-grade 0.035” (0.89 mm) guidewire for MRI right and left heart catheterization at 1.5 T that has an internal probe to monitor temperature in real-time, and that has both tip and shaft visibility as well as suitable flexibility. Methods The design has an internal fiberoptic temperature probe, as well as a distal solenoid to enhance tip visibility on a loopless antenna. We tested different tip-solenoid configurations to balance heating and signal profiles. We tested mechanical performance in vitro and in vivo in comparison with a popular clinical nitinol guidewire. Results The solenoid displaced the point of maximal heating (“hot spot”) from the tip to a more proximal location where it can be measured without impairing guidewire flexion. Probe pullback allowed creation of lengthwise guidewire temperature maps that allowed rapid evaluation of design prototypes. Distal-only solenoid attachment offered the best compromise between tip visibility and heating among design candidates. When fixed at the hot spot, the internal probe consistently reflected the maximum temperature compared external probes. Real-time temperature monitoring was performed during porcine left heart catheterization. Heating was negligible using normal operating parameters (flip angle, 45°; SAR, 1.01 W/kg); the temperature increased by 4.2°C only during high RF power mode (flip angle, 90°; SAR, 3.96 W/kg) and only when the guidewire was isolated from blood cooling effects by an introducer sheath. The tip flexibility and in vivo performance of the final guidewire design were similar to a popular commercial guidewire. Conclusions We integrated a fiberoptic temperature probe inside a 0.035” MRI guidewire

  6. Opportunities for international collaboration in industrial pollution prevention

    SciTech Connect

    Young, J.K.; Fowler, K.M.

    1993-08-01

    The goal of this paper is to describe international research opportunities for in-process reduction of wastes from industrial processes. Written responses from 52 researchers were obtained from 15 different countries in mid-1992. Each researcher provided information about products to reduce waste in industrial processes and recommended joint activities and mechanisms for working collaboratively with the United States.

  7. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity.

    PubMed

    Liu, Zhenyi; Brunskill, Eric; Boyle, Scott; Chen, Shuang; Turkoz, Mustafa; Guo, Yuxuan; Grant, Rachel; Kopan, Raphael

    2015-03-15

    We have previously described the creation and analysis of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::Cre(LO), that marked cells experiencing relatively high levels of Notch1 activation. Here, we report and characterize a second line with improved sensitivity (N1IP::Cre(HI)) to mark cells experiencing lower levels of Notch1 activation. This improvement was achieved by increasing transcript stability and by restoring the native carboxy terminus of Cre, resulting in a five- to tenfold increase in Cre activity. The magnitude of this effect probably impacts Cre activity in strains with carboxy-terminal Ert2 fusion. These two trap lines and the related line N1IP::Cre(ERT2) form a complementary mapping tool kit to identify changes in Notch1 activation patterns in vivo as the consequence of genetic or pharmaceutical intervention, and illustrate the variation in Notch1 signal strength from one tissue to the next and across developmental time. PMID:25725069

  8. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity

    PubMed Central

    Liu, Zhenyi; Brunskill, Eric; Boyle, Scott; Chen, Shuang; Turkoz, Mustafa; Guo, Yuxuan; Grant, Rachel; Kopan, Raphael

    2015-01-01

    We have previously described the creation and analysis of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::CreLO, that marked cells experiencing relatively high levels of Notch1 activation. Here, we report and characterize a second line with improved sensitivity (N1IP::CreHI) to mark cells experiencing lower levels of Notch1 activation. This improvement was achieved by increasing transcript stability and by restoring the native carboxy terminus of Cre, resulting in a five- to tenfold increase in Cre activity. The magnitude of this effect probably impacts Cre activity in strains with carboxy-terminal Ert2 fusion. These two trap lines and the related line N1IP::CreERT2 form a complementary mapping tool kit to identify changes in Notch1 activation patterns in vivo as the consequence of genetic or pharmaceutical intervention, and illustrate the variation in Notch1 signal strength from one tissue to the next and across developmental time. PMID:25725069

  9. Part II, Provider perspectives: should patients be activated to request evidence-based medicine? a qualitative study of the VA project to implement diuretics (VAPID)

    PubMed Central

    2010-01-01

    Background Hypertension guidelines recommend the use of thiazide diuretics as first-line therapy for uncomplicated hypertension, yet diuretics are under-prescribed, and hypertension is frequently inadequately treated. This qualitative evaluation of provider attitudes follows a randomized controlled trial of a patient activation strategy in which hypertensive patients received letters and incentives to discuss thiazides with their provider. The strategy prompted high discussion rates and enhanced thiazide-prescribing rates. Our objective was to interview providers to understand the effectiveness and acceptability of the intervention from their perspective, as well as the suitability of patient activation for more widespread guideline implementation. Methods Semi-structured phone interviews were conducted with 21 primary care providers. Interviews were transcribed verbatim and reviewed by the interviewer before being analyzed for content. Interviews were coded, and relevant themes and specific responses were identified, grouped, and compared. Results Of the 21 providers interviewed, 20 (95%) had a positive opinion of the intervention, and 18 of 20 (90%) thought the strategy was suitable for wider use. In explaining their opinions of the intervention, many providers discussed a positive effect on treatment, but they more often focused on the process of patient activation itself, describing how the intervention facilitated discussions by informing patients and making them more pro-active. Regarding effectiveness, providers suggested the intervention worked like a reminder, highlighted oversights, or changed their approach to hypertension management. Many providers also explained that the intervention 'aligned' patients' objectives with theirs, or made patients more likely to accept a change in medications. Negative aspects were mentioned infrequently, but concerns about the use of financial incentives were most common. Relevant barriers to initiating thiazide treatment

  10. Negotiating among Opportunity and Constraint: The Participation of Young People in Out-of-School-Time Activities. Chapin Hall Working Paper

    ERIC Educational Resources Information Center

    Chaskin, Robert J.; Baker, Stephen

    2006-01-01

    In recent years, there has been increased policy interest in the way young people spend their time out of school, and in promoting the availability of opportunities for them to spend this time in productive and developmentally supportive ways. Out-of-school opportunities (such as arts and music programs, sports teams, community service, youth …

  11. Nanotechnology: Opportunities and Challenges

    NASA Technical Reports Server (NTRS)

    Meyyappan, Meyya

    2003-01-01

    Nanotechnology seeks to exploit novel physical, chemical, biological, mechanical, electrical, and other properties, which arise primarily due to the nanoscale nature of certain materials. A key example is carbon nanotubes (CNTs) which exhibit unique electrical and extraordinary mechanical properties and offer remarkable potential for revolutionary applications in electronics devices, computing, and data storage technology, sensors, composites, nanoelectromechanical systems (NEMS), and as tip in scanning probe microscopy (SPM) for imaging and nanolithography. Thus the CNT synthesis, characterization, and applications touch upon all disciplines of science and engineering. This presentation will provide an overview and progress report on this and other major research candidates in Nanotechnology and address opportunities and challenges ahead.

  12. Youth Violence Prevention and Safety: Opportunities for Health Care Providers.

    PubMed

    Duke, Naomi Nichele; Borowsky, Iris Wagman

    2015-10-01

    Violence involvement remains a leading cause of morbidity and mortality for youth and young adults in the United States. The impact of adverse childhood experiences on violence involvement can be translated to the cellular level, including alterations in brain structure and function responsible for stress reactivity and coping. This knowledge is counterbalanced by a growing understanding of what works in the realm of youth violence prevention. Incorporating a resilience framework, with its focus on building developmental assets and resources at individual, family, and community levels, offers a renewed approach to fostering healthy behaviors and coping strategies.

  13. Do We Provide Opportunities or Only Value Productivity?

    ERIC Educational Resources Information Center

    de la Iglesia Mayol, Begona

    2006-01-01

    With a view to improving the quality of life of persons living with disabilities without direct intervention but in the context of action at the level of their personal development, and with the institutional support of the University of the Balearic Islands and funding from "SA Nostra" Caixa de Balears, we decided to develop, implement and…

  14. Isothermal Titration Calorimetry Can Provide Critical Thinking Opportunities

    ERIC Educational Resources Information Center

    Moore, Dale E.; Goode, David R.; Seney, Caryn S.; Boatwright, Jennifer M.

    2016-01-01

    College chemistry faculties might not have considered including isothermal titration calorimetry (ITC) in their majors' curriculum because experimental data from this instrumental method are often analyzed via automation (software). However, the software-based data analysis can be replaced with a spreadsheet-based analysis that is readily…

  15. Athletics for All: Providing Opportunities for Students of All Abilities

    ERIC Educational Resources Information Center

    Whitmer, Regina

    2013-01-01

    The glory days of high school sports are no longer reserved for dream team athletes, as athletic directors are increasingly opening up sports to all students, regardless of ability, and seeing winning results on the field and off. This push is reflected in the most recent National Federation of State High School Associations (NFHS) survey, which…

  16. Gifted Children & the Arts: Providing Opportunities for All

    ERIC Educational Resources Information Center

    Schroth, Stephen T.; Helfer, Jason A.

    2011-01-01

    Knowledge of English/language arts, mathematics, and the sciences are considered important in the development of gifted children. Familiarity with the arts--music, the visual arts, dance, creative writing, and theatre--is, for many, a more difficult proposition. Budget cutbacks have marginalized the art offerings in numerous school districts…

  17. Building a Strong Foundation: Apprenticeships Provide Earning, Learning Opportunities

    ERIC Educational Resources Information Center

    Finkel, Ed

    2016-01-01

    Partnerships between community colleges and employers to create apprenticeships have been around for decades. These traditionally have covered fields like the building trades--electrical, construction and others--as well as heavy manufacturing like the automobile industry. Inspired partly by a new federal apprenticeship consortium--and $175…

  18. Soot and short-lived pollutants provide political opportunity

    NASA Astrophysics Data System (ADS)

    Victor, David G.; Zaelke, Durwood; Ramanathan, Veerabhadran

    2015-09-01

    Cutting levels of soot and other short-lived pollutants delivers tangible benefits and helps governments to build confidence that collective action on climate change is feasible. After the Paris climate meeting this December, actually reducing these pollutants will be essential to the credibility of the diplomatic process.

  19. Private Training Providers in Australia: Their Characteristics and Training Activities. A National Vocational Education and Training Research and Evaluation Program Report

    ERIC Educational Resources Information Center

    Harris, Roger; Simons, Michele; McCarthy, Carmel

    2006-01-01

    This study examines the nature of the training activity of private registered training organisations (RTOs) offered to Australian students in 2003, based on data from a national sample of 330 RTOs. The study also provides estimates of the private sector's overall contribution to the total vocational education and training (VET) effort in Australia…

  20. The Turn the Tables Technique (T[cube]): A Program Activity to Provide Group Facilitators Insight into Teen Sexual Behaviors and Beliefs

    ERIC Educational Resources Information Center

    Sclafane, Jamie Heather; Merves, Marni Loiacono; Rivera, Angelic; Long, Laura; Wilson, Ken; Bauman, Laurie J.

    2012-01-01

    The Turn the Tables Technique (T[cube]) is an activity designed to provide group facilitators who lead HIV/STI prevention and sexual health promotion programs with detailed and current information on teenagers' sexual behaviors and beliefs. This information can be used throughout a program to tailor content. Included is a detailed lesson plan of…

  1. Children with Special Needs in Family Day Care Homes: A Handbook of Approaches and Activities for Family Day Care Home Providers.

    ERIC Educational Resources Information Center

    de la Brosse, Beatrice

    Practical information and sample teaching activities for child caregivers who work with young developmentally disabled children in family day care settings are provided in this manual. Each chapter shares a typical experience a caregiver may have with a particular child. Chapter 1 focuses on getting to know a new child, initial expectations, and…

  2. Heat pump technology: Responding to new opportunities

    SciTech Connect

    Baxter, V.D.; Creswick, F.A. ); Snelson, W.K. . Institute for Mechnical Engineering)

    1993-01-01

    This paper provides an update on advanced heat pump research and development activities in the United States and Canada. Under the general area of vapor compression technology a major need toward which these research programs are directed is the development of viable alternatives to HCFC-22 for heat pump and air-conditioning applications. The HCFC phaseout provides an opportunity to develop advanced refrigeration equipment for the new refrigerants which has higher energy efficiency than current heat pump systems. Programs are underway in both industry and government laboratories and are characterized by close collaboration between major manufacturers and government agencies to plan and execute the research. Under the general area of thermally activated heat pump technology, there are several cooperative early-commercialization activities being conducted on gas-fired heat pumps and chillers by government, HVAC industry, and gas utility organizations.

  3. Family Day Care Provider Handbook

    ERIC Educational Resources Information Center

    New York State Office of Children and Family Services, 2006

    2006-01-01

    Family day care providers are responsible for creating a high-quality program where children have opportunities to grow, learn and thrive. Part of providing high-quality child care includes complying with the family day care regulations from the New York State Office of Children and Family Services (OCFS). This Handbook will help day care…

  4. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

    PubMed Central

    Reiser, H; Freeman, G J; Razi-Wolf, Z; Gimmi, C D; Benacerraf, B; Nadler, L M

    1992-01-01

    We demonstrate that the murine B7 (mB7) protein is a potent costimulatory molecule for the activation of resting murine CD4+ T cells through the T-cell receptor (TCR)/CD3 complex. Stable mB7-transfected Chinese hamster ovary cells, but not vector-transfected controls, synergize with anti-CD3 monoclonal antibody and Con A-induced T-cell activation, resulting ultimately in proliferation. mB7 exerted its effect by inducing production of interleukin 2 and expression of the interleukin 2 receptor. Thus, mB7 costimulates T-cell activation through the TCR/CD3 complex by positively modulating the normal pathway of T-cell expansion. In contrast to the pronounced effect of mB7 on the activation of T cells through the TCR/CD3 complex, the mB7-transfected CHO cell line costimulated T-cell activation via the glycosylphosphatidylinositol-anchored proteins Thy-1 and Ly-6A.2 only inefficiently. Finally, the combination of a calcium ionophore and mB7 is not sufficient to cause T-cell proliferation, while the combination of a calcium ionophore and phorbol 12-myristate 13-acetate (PMA) stimulates T cells efficiently. The signals that mB7 and PMA provide for murine T lymphocyte activation are therefore not interchangeable, although both costimulate activation through the TCR/CD3 complex. Images PMID:1370349

  5. 75 FR 52956 - Funding Opportunity

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... HUMAN SERVICES Administration on Aging Funding Opportunity Purpose of Notice: Availability of funding opportunity announcement. Funding Opportunity Title/Program Name: Older Americans Act (OAA), Title VI, Part A... funding opportunity. Funding Opportunity Number: Program Announcement No. is HHS-2011-...

  6. 20 CFR 664.610 - How is the summer employment opportunities element administered?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF LABOR YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment... and Local Boards are responsible for ensuring that the local youth program provides summer employment... used to provide summer youth employment opportunities, these providers must be selected by awarding...

  7. 20 CFR 664.610 - How is the summer employment opportunities element administered?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF LABOR YOUTH ACTIVITIES UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Summer Employment... and Local Boards are responsible for ensuring that the local youth program provides summer employment... used to provide summer youth employment opportunities, these providers must be selected by awarding...

  8. Opportunity Cost: A Reexamination

    ERIC Educational Resources Information Center

    Parkin, Michael

    2016-01-01

    Is opportunity cost an ambiguous and arbitrary concept or a simple, straightforward, and fruitful one? This reexamination of opportunity cost addresses this question, and shows that opportunity cost is an ambiguous concept because "two" definitions are in widespread use. One of the definitions is indeed simple, fruitful, and one that…

  9. High-energy photon activation tandem mass spectrometry provides unprecedented insights into the structure of highly sulfated oligosaccharides extracted from macroalgal cell walls.

    PubMed

    Ropartz, David; Giuliani, Alexandre; Hervé, Cécile; Geairon, Audrey; Jam, Murielle; Czjzek, Mirjam; Rogniaux, Hélène

    2015-01-20

    Extreme ultraviolet photon activation tandem mass spectrometry (MS) at 69 nm (18 eV) was used to characterize mixtures of oligo-porphyrans, a class of highly sulfated oligosaccharides. Porphyrans, hybrid polymers whose structures are far from known, continue to provide a challenge for analytical method development. Activation by 18 eV photons led to a rich fragmentation of the oligo-porphyrans, with many cross-ring and glycosidic cleavages. In contrast to multistage MSn strategies such as activated electron photodetachment dissociation, a single step of irradiation by energetic UV of multiply charged anions led to a complete fragmentation of the oligo-porphyrans. In both ionization modes, the sulfate groups were retained on the backbone, which allowed the pattern of these modifications along the porphyran backbone to be described in unprecedented detail. Many structures released by the enzymatic degradation of the porphyran were completely resolved, including isomers. This work extends the existing knowledge of the structure of porphyrans. In addition, it provides a new demonstration of the potential of activation by high-energy photons for the structural analysis of oligosaccharides, even in unseparated mixtures, with a particular focus on sulfated compounds.

  10. Relative Preservation of Advanced Activities in Daily Living among Patients with Mild-to-Moderate Dementia in the Community and Overview of Support Provided by Family Caregivers

    PubMed Central

    Takechi, Hajime; Kokuryu, Atsuko; Kubota, Tomoko; Yamada, Hiroko

    2012-01-01

    Little is known about the extent to which advanced activities of daily living among patients with dementia are preserved and how family caregivers of these patients support them in the community. In this cross-sectional assessment of pairs of patients with dementia and their family caregivers, we evaluated basic, instrumental, and advanced activities of daily living by comparing past and present status observed by caregivers with subjective estimations by patients with dementia. We also asked about ways in which support was provided by family caregivers. Thirty-nine pairs of patients with dementia and caregivers who presented to our memory clinic were interviewed. The mean age of patients with dementia was 75.3 ± 7.0 years, and Mini-Mental State Examination scores were 22.3 ± 3.4. We found relative preservation of advanced activities of daily living compared with instrumental activities of daily living. Caregivers provided instrumental, informational, and reminding support to patients with dementia. These findings may reinforce the concept of person-centered support of patients with dementia in the community. PMID:22811947

  11. Links and opportunities

    NASA Astrophysics Data System (ADS)

    1999-09-01

    At the end of June a new website was launched to enable young people to get involved with the UK's national Foresight programme and to help shape the future. `School of the Future - Young people with Foresight' will provide young people with the means to contribute to the national programme which develops scenarios of the future, looking at possible needs, opportunities or threats and deciding what should be done now to make sure these challenges can be met. The site can be found at www.asset.org.uk and it will be run by the Association for Schools' Science, Engineering and Technology (ASSET). The latest round of Foresight began in April and panels are taking a look at the aging population, crime prevention, built environment and transport, aerospace and systems, energy and the natural environment, information, communications and media, materials and sustainable development, amongst other topics. Information about Foresight activities and events can be obtained from the Office of Science and Technology or the Foresight Knowledge pool at www.foresight.gov.uk. The pool will act as a unique and freely accessible electronic library of views and information about the future that young people will be able to draw on for assistance and reference material. Futher assistance for students will also be on offer from museums and art galleries from now on, thanks to additional funding which has been made available over the next three years. Forty museums and galleries will share up to #2.5m for projects intended to improve students' literacy, numeracy and science skills as well as their understanding of history and art. Examples of the imaginative projects which have been put forward include use of the large collection of steam engines at the Museum of Science and Industry in Manchester to assist boys' science and literacy skills. The Museum of London will be working with over 2000 schools in the South East to provide materials for the schools' own mini-museums on the Romans

  12. Space weather: Challenges and Opportunities (Invited)

    NASA Astrophysics Data System (ADS)

    Bogdan, T. J.

    2009-12-01

    The Space Weather Prediction Center (SWPC) has the following legal mandates to: a) Continuously monitor, measure, and specify the space environment, b) Provide timely and accurate space weather data, operational forecasts, alerts, and warnings of hazardous space weather phenomena, c) Provide scientific stewardship of, and public access to, space weather data and products, d) Understand the processes that influence space weather and develop applications for the user community and e) Develop new and improved products and transition them into operations to meet evolving space weather user needs. This presentation will discuss the challenges and opportunities that NOAA and the SWPC face in addressing these mandates. This includes coordination of space environment activities across federal agencies and the strategic planning for NOAA's space weather services, integration of space weather activities as well as critical dependencies of space weather services on current and future operational environmental satellites.

  13. Metabolic activation of clopidogrel: in vitro data provide conflicting evidence for the contributions of CYP2C19 and PON1.

    PubMed

    Polasek, Thomas M; Doogue, Matthew P; Miners, John O

    2011-12-01

    The recent report that clopidogrel efficacy may be more dependent on paraoxonase-1 (PON1) than on cytochrome P450 2C19 (CYP2C19) activity raises questions about the roles of these and other enzymes in clopidogrel activation. To provide insight into the emerging PON1 versus CYP2C19 debate, this commentary summarizes the clinical evidence on the pharmacokinetic determinants of clopidogrel efficacy. We then review the in vitro studies investigating the enzymes involved in clopidogrel activation, and comment on their strengths and limitations. There is agreement amongst in vitro studies regarding the involvement of CYP1A2 and CYP2B6 in the metabolism of clopidogrel to 2-oxo-clopidogrel. However, the evidence for other CYP enzymes in the first activation step (e.g. CYP2C19 and CYP3A4) is inconsistent and dependent on the in vitro test system and laboratory. All major drug metabolizing CYP enzymes are capable of converting 2-oxo-clopidogrel to sulfenic acid intermediates that subsequently form the active thiol metabolite. However, the extent of CYP involvement in this second step has been challenged, and new evidence suggests that CYP-independent hydrolytic cleavage of the thioester bond may be more important than oxidative metabolism.

  14. trans-dominant mutants of E1A provide genetic evidence that the zinc finger of the trans-activating domain binds a transcription factor.

    PubMed Central

    Webster, L C; Ricciardi, R P

    1991-01-01

    The 289R E1A protein of adenovirus stimulates transcription of early viral and certain cellular genes. trans-Activation requires residues 140 to 188, which encompass a zinc finger. Several studies have indicated that trans-activation by E1A is mediated through cellular transcription factors. In particular, the ability of the trans-dominant E1A point mutant hr5 (Ser-185 to Asn) to inhibit wild-type E1A trans-activation was proposed to result from the sequestration of a cellular factor. Using site-directed mutagenesis, we individually replaced every residue within and flanking the trans-activating domain with a conservative amino acid, revealing 16 critical residues. Six of the individual substitutions lying in a contiguous stretch C terminal to the zinc finger (carboxyl region183-188) imparted a trans-dominant phenotype. trans-Dominance was even produced by deletion of the entire carboxyl region183-188. Conversely, an intact finger region147-177 was absolutely required for trans-dominance, since second-site substitution of every critical residue in this region abrogated the trans-dominant phenotype of the hr5 protein. These data indicate that the finger region147-177 bind a limiting cellular transcription factor and that the carboxyl region183-188 provides a separate and essential function. In addition, we show that four negatively charged residues within the trans-activating domain do not comprise a distinct acidic activating region. We present a model in which the trans-activating domain of E1A binds to two different cellular protein targets through the finger and carboxyl regions. Images PMID:1831535

  15. Opportunities in Community College Education.

    ERIC Educational Resources Information Center

    Lumsden, D. Barry; And Others

    1981-01-01

    Presents the results of a 1980 national survey of graduate training opportunities in community college education. Offers a table listing the 94 universities providing graduate-level instruction about community colleges and the 304 courses they offer. Discusses the value of the study for curriculum and research planning. (DMM)

  16. Learning Opportunities for Older People.

    ERIC Educational Resources Information Center

    MacKeracher, Dorothy

    1980-01-01

    The author summarizes a conference on learning opportunities for older people by discussing six issues: (1) perspectives of older people and service providers; (2) categorization of older learners; (3) learning needs of older people; (4) participation rates; (5) government policies; and (6) curriculum concerns. (SK)

  17. The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs.

    PubMed

    Pitcher, Lisa A; Mathis, Meredith A; Young, Jennifer A; DeFord, Laura M; Purtic, Bozidar; Wulfing, Christoph; van Oers, Nicolai S C

    2005-12-01

    T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine-based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR zetazeta and CD3 gammaepsilon/deltaepsilon. To delineate the specific role of the zeta ITAM in T cell development and TCR signal transmission, we compared the properties of T cells from different TCR zeta-transgenic lines wherein tyrosine-to-phenylalanine substitutions had been introduced in the zeta subunit. These lines lack selected phosphorylated forms of TCR zeta including just p23, both p21 and p23, or all phospho-zeta derivatives. We report herein that the efficiency of positive selection in HY TCR-transgenic female mice was directly related to the number of zeta ITAM in the TCR. In contrast, TCR-mediated signal transmission and T cell proliferative responses following agonist peptide stimulation were similar and independent of the zeta ITAM. Only the duration of MAPK activation was affected by multiple zeta ITAM substitutions. These results strongly suggest that the ITAM in the CD3 gammaepsilon/deltaepsilon module can provide normal TCR signal transmission, with zeta ITAM providing a secondary function facilitating MAPK activation and positive selection.

  18. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

    PubMed Central

    Van Kanegan, Michael J.; Dunn, Denise E.; Kaltenbach, Linda S.; Shah, Bijal; He, Dong Ning; McCoy, Daniel D.; Yang, Peiying; Peng, Jiangnan; Shen, Li; Du, Lin; Cichewicz, Robert H.; Newman, Robert A.; Lo, Donald C.

    2016-01-01

    We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its principal cardiac glycoside constituent, oleandrin, via induction of the potent neurotrophic factor brain-derived neurotrophic factor (BDNF). However, we also noted that the concentration-relation for PBI-05204 in the brain slice oxygen-glucose deprivation (OGD) model is considerably broader than that for oleandrin as a single agent. We thus surmised that PBI-05204 contains an additional neuroprotective component(s), distinct from oleandrin. We report here that neuroprotective activity is also provided by the triterpenoid constituents of PBI-05204, notably oleanolic acid. We demonstrate that a sub-fraction of PBI-05204 (Fraction 0–4) containing oleanolic and other triterpenoids, but without cardiac glycosides, induces the expression of cellular antioxidant gene transcription programs regulated through antioxidant transcriptional response elements (AREs). Finally, we show that Fraction 0–4 provides broad neuroprotection in organotypic brain slice models for neurodegeneration driven by amyloid precursor protein (APP) and tau implicated in Alzheimer’s disease and frontotemporal dementias, respectively, in addition to ischemic injury modeled by OGD. PMID:27172999

  19. Critical technologies research: Opportunities for DOE

    SciTech Connect

    Not Available

    1992-12-01

    Recent studies have identified a number of critical technologies that are essential to the nation's defense, economic competitiveness, energy independence, and betterment of public health. The National Critical Technologies Panel (NCTP) has identified the following critical technology areas: Aeronautics and Surface Transportation; Biotechnology and Life Sciences; Energy and Environment; Information and Communications; Manufacturing; and Materials. Sponsored by the Department of Energy's Office of Energy Research (OER), the Critical Technologies Research Workshop was held in May 1992. Approximately 100 scientists, engineers, and managers from the national laboratories, industry, academia, and govemment participated. The objective of the Berkeley Workshop was to advance the role of the DOE multiprogram energy laboratories in critical technologies research by describing, defining, and illustrating research areas, opportunities, resources, and key decisions necessary to achieve national research goals. An agenda was developed that looked at DOE's capabilities and options for research in critical technologies and provided a forum for industry, academia, govemment, and the national laboratories to address: Critical technology research needs; existing research activities and resources; capabilities of the national laboratories; and opportunities for national laboratories, industries, and universities. The Workshop included plenary sessions in which presentations by technology and policy leaders set the context for further inquiry into critical technology issues and research opportunities. Separate sessions then focused on each of the following major areas of technology: Advanced materials; biotechnology and life sciences; energy and environment; information and communication; and manufacturing and transportation.

  20. Critical technologies research: Opportunities for DOE

    SciTech Connect

    Not Available

    1992-12-01

    Recent studies have identified a number of critical technologies that are essential to the nation`s defense, economic competitiveness, energy independence, and betterment of public health. The National Critical Technologies Panel (NCTP) has identified the following critical technology areas: Aeronautics and Surface Transportation; Biotechnology and Life Sciences; Energy and Environment; Information and Communications; Manufacturing; and Materials. Sponsored by the Department of Energy`s Office of Energy Research (OER), the Critical Technologies Research Workshop was held in May 1992. Approximately 100 scientists, engineers, and managers from the national laboratories, industry, academia, and govemment participated. The objective of the Berkeley Workshop was to advance the role of the DOE multiprogram energy laboratories in critical technologies research by describing, defining, and illustrating research areas, opportunities, resources, and key decisions necessary to achieve national research goals. An agenda was developed that looked at DOE`s capabilities and options for research in critical technologies and provided a forum for industry, academia, govemment, and the national laboratories to address: Critical technology research needs; existing research activities and resources; capabilities of the national laboratories; and opportunities for national laboratories, industries, and universities. The Workshop included plenary sessions in which presentations by technology and policy leaders set the context for further inquiry into critical technology issues and research opportunities. Separate sessions then focused on each of the following major areas of technology: Advanced materials; biotechnology and life sciences; energy and environment; information and communication; and manufacturing and transportation.

  1. Career opportunities in clinical engineering.

    PubMed

    Morse, W A

    1992-01-01

    The varied career opportunities open to clinical engineers are described in this paper. Many of these opportunities are within the medical device industry in research, development, manufacturing design, regulatory activities, production, operations, sales, marketing, service, and management. Additional opportunities are available in hospitals, with the Veterans Administration, or working as an entrepreneur or a consultant. Each of these careers requires specific training and skills, and they all require a fundamental scientific knowledge of physical principles and mathematics. Research and management, however, require different educational preparation. The research emphasis should be on theoretical principles and creativity; the management emphasis should be on financial and labor problems. In all clinical engineering careers, the individual is a problem solver. PMID:10120058

  2. Opportunities with Polarized Hadron Beams

    NASA Astrophysics Data System (ADS)

    Lorenzon, Wolfgang

    2016-02-01

    Spin physics at future hadron facilities provide unique opportunities for the study of QCD well beyond those available at existing facilities. Opportunities with polarized protons in the Fermilab Main Injector are discussed that encompass polarized Drell-Yan scattering of unprecedented precision and also enable measurements of transversity, helicty and other transverse momentum dependent distributions. Forthcoming measurements at COMPASS-II that aim to test fundamental predictions of non-perturbative QCD, and complementary studies at RHIC-Spin that address, among others, open puzzles such as the sharing of the nucleon spin among its constituents are also discussed.

  3. [Standardization of measurement of catalytic activity concentration of enzymes--current situation regarding the external quality assessment program provided by the Japan Medical Association].

    PubMed

    Maekawa, Masato

    2010-01-01

    Measurement of the catalytic activity concentration of enzymes has been standardized using a traceability chain, consisting a reference measurement system for enzyme catalytic activity and reference standard-JSCC enzyme. The Japan Medical Association (JMA) has provided an external quality assessment (EQA) survey program for clinical laboratory testing. More than 3,100 clinical laboratories participated in 2008. The EQA program indicated that standardization of the measurement of the catalytic activity concentration of enzymes has been completed for AST, ALT, LD, ALP, gammaGT, and CK in more than 90% laboratories, and for Amy and ChE in nearly 80% of laboratories. Because such a large survey program must use artificial specimens, a matrix effect cannot be avoided, especially in dry chemistry. However, the bias produced by a matrix effect usually has a predictable tendency: it can be corrected. Next, after standardization of the measurement of the catalytic activity concentration of enzymes, we should develop and use common reference intervals. On completing the standardization, we can make standard medical decisions using reference measurement systems and rules.

  4. Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.

    PubMed

    Borsato, Débora M; Prudente, Arthur S; Döll-Boscardin, Patrícia M; Borsato, Aurélio V; Luz, Cynthia F P; Maia, Beatriz H L N S; Cabrini, Daniela A; Otuki, Michel F; Miguel, Marilis D; Farago, Paulo V; Miguel, Obdulio G

    2014-07-01

    Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ± 5%. This extract decreased the myeloperoxidase activity in 75 ± 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ± 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.

  5. Evolutionary constraints or opportunities?

    PubMed Central

    Sharov, Alexei A.

    2014-01-01

    Natural selection is traditionally viewed as a leading factor of evolution, whereas variation is assumed to be random and non-directional. Any order in variation is attributed to epigenetic or developmental constraints that can hinder the action of natural selection. In contrast I consider the positive role of epigenetic mechanisms in evolution because they provide organisms with opportunities for rapid adaptive change. Because the term “constraint” has negative connotations, I use the term “regulated variation” to emphasize the adaptive nature of phenotypic variation, which helps populations and species to survive and evolve in changing environments. The capacity to produce regulated variation is a phenotypic property, which is not described in the genome. Instead, the genome acts as a switchboard, where mostly random mutations switch “on” or “off” preexisting functional capacities of organism components. Thus, there are two channels of heredity: informational (genomic) and structure-functional (phenotypic). Functional capacities of organisms most likely emerged in a chain of modifications and combinations of more simple ancestral functions. The role of DNA has been to keep records of these changes (without describing the result) so that they can be reproduced in the following generations. Evolutionary opportunities include adjustments of individual functions, multitasking, connection between various components of an organism, and interaction between organisms. The adaptive nature of regulated variation can be explained by the differential success of lineages in macro-evolution. Lineages with more advantageous patterns of regulated variation are likely to produce more species and secure more resources (i.e., long-term lineage selection). PMID:24769155

  6. Evolutionary constraints or opportunities?

    PubMed

    Sharov, Alexei A

    2014-04-22

    Natural selection is traditionally viewed as a leading factor of evolution, whereas variation is assumed to be random and non-directional. Any order in variation is attributed to epigenetic or developmental constraints that can hinder the action of natural selection. In contrast I consider the positive role of epigenetic mechanisms in evolution because they provide organisms with opportunities for rapid adaptive change. Because the term "constraint" has negative connotations, I use the term "regulated variation" to emphasize the adaptive nature of phenotypic variation, which helps populations and species to survive and evolve in changing environments. The capacity to produce regulated variation is a phenotypic property, which is not described in the genome. Instead, the genome acts as a switchboard, where mostly random mutations switch "on" or "off" preexisting functional capacities of organism components. Thus, there are two channels of heredity: informational (genomic) and structure-functional (phenotypic). Functional capacities of organisms most likely emerged in a chain of modifications and combinations of more simple ancestral functions. The role of DNA has been to keep records of these changes (without describing the result) so that they can be reproduced in the following generations. Evolutionary opportunities include adjustments of individual functions, multitasking, connection between various components of an organism, and interaction between organisms. The adaptive nature of regulated variation can be explained by the differential success of lineages in macro-evolution. Lineages with more advantageous patterns of regulated variation are likely to produce more species and secure more resources (i.e., long-term lineage selection).

  7. Evolutionary constraints or opportunities?

    PubMed

    Sharov, Alexei A

    2014-09-01

    Natural selection is traditionally viewed as a leading factor of evolution, whereas variation is assumed to be random and non-directional. Any order in variation is attributed to epigenetic or developmental constraints that can hinder the action of natural selection. In contrast I consider the positive role of epigenetic mechanisms in evolution because they provide organisms with opportunities for rapid adaptive change. Because the term "constraint" has negative connotations, I use the term "regulated variation" to emphasize the adaptive nature of phenotypic variation, which helps populations and species to survive and evolve in changing environments. The capacity to produce regulated variation is a phenotypic property, which is not described in the genome. Instead, the genome acts as a switchboard, where mostly random mutations switch "on" or "off" preexisting functional capacities of organism components. Thus, there are two channels of heredity: informational (genomic) and structure-functional (phenotypic). Functional capacities of organisms most likely emerged in a chain of modifications and combinations of more simple ancestral functions. The role of DNA has been to keep records of these changes (without describing the result) so that they can be reproduced in the following generations. Evolutionary opportunities include adjustments of individual functions, multitasking, connection between various components of an organism, and interaction between organisms. The adaptive nature of regulated variation can be explained by the differential success of lineages in macro-evolution. Lineages with more advantageous patterns of regulated variation are likely to produce more species and secure more resources (i.e., long-term lineage selection).

  8. Provider panel presentations.

    PubMed

    Buckelew, Larry C; Harvey, Deborah; Mello, Joe

    2003-08-01

    To wrap up the three big items--attracting talent, the professional nurse role, and our structural disadvantages--I would offer the following take-away thoughts: We ought to do what we can to get our disproportionate share of RNs out of the health care system to work in dialysis. If we work together, we have a shot at making that happen. As an industry, we must exploit our strengths. We have to exploit the pride that comes in the services and the care that we provide. We need to create in a very visual way that difference for nurses who are considering which area of specialty to go into and where to create their careers. We, as providers, have a huge opportunity to create the right environment for our nurses. That's something we own. We have to fix it. We have to create a better place to work for nurses than any place else. We must create a more enriching place for nurses than anywhere else. That's up to us. I know a lot of us on the provider side are doing tons of things to make that happen and we need to keep driving that. We need a level playing field. We've proven the fact that we can deliver clinical outcomes with the best. Now we need help from our biggest customer to make sure we can compete for the resources that are necessary to sustain and improve those clinical outcomes on an ongoing basis. PMID:14533522

  9. NASA's Flight Opportunities Program

    NASA Video Gallery

    NASA's Flight Opportunities Program is facilitating low-cost access to suborbital space, where researchers can test technologies using commercially developed vehicles. Suborbital flights can quickl...

  10. The crystal structure of Escherichia coli maltodextrin phosphorylase provides an explanation for the activity without control in this basic archetype of a phosphorylase.

    PubMed Central

    Watson, K A; Schinzel, R; Palm, D; Johnson, L N

    1997-01-01

    In animals, glycogen phosphorylase (GP) exists in an inactive (T state) and an active (R state) equilibrium that can be altered by allosteric effectors or covalent modification. In Escherichia coli, the activity of maltodextrin phosphorylase (MalP) is controlled by induction at the level of gene expression, and the enzyme exhibits no regulatory properties. We report the crystal structure of E. coli maltodextrin phosphorylase refined to 2.4 A resolution. The molecule consists of a dimer with 796 amino acids per monomer, with 46% sequence identity to the mammalian enzyme. The overall structure of MalP shows a similar fold to GP and the catalytic sites are highly conserved. However, the relative orientation of the two subunits in E. coli MalP is different from both the T and R state GP structures, and there are significant changes at the subunit-subunit interfaces. The sequence changes result in loss of each of the control sites present in rabbit muscle GP. As a result of the changes at the subunit interface, the 280s loop, which in T state GP acts as a gate to control access to the catalytic site, is held in an open conformation in MalP. The open access to the conserved catalytic site provides an explanation for the activity without control in this basic archetype of a phosphorylase. PMID:9009262

  11. Cutaneous activation of the inhibitory L30 interneurons provides a mechanism for regulating adaptive gain control in the siphon withdrawal reflex of Aplysia.

    PubMed

    Fischer, T M; Carew, T J

    1995-01-01

    The functional role of inhibition in the neural network underlying the siphon withdrawal response (SWR) of Aplysia was assessed by examining a recurrent circuit comprised of identified inhibitory interneurons (L30s), and excitatory interneurons (L29s). We previously showed that activity-dependent potentiation of the L30 inhibitory synapse onto L29 can regulate the net excitatory input elicited by tactile siphon stimulation onto siphon motor neurons (LFS cells) (Fischer and Carew, 1993a). To explore the functional significance of L30 potentiated inhibition, we have examined how a behaviorally relevant stimulus that activates the L30 interneurons modulates the SWR circuit. Utilizing a reduced preparation, we show that weak tactile stimulation of the tail strongly activates the L30s, and leads to significant potentiation of the L30 synapse. Next, we demonstrate that similar weak tail stimulation produces significant inhibition of siphon tap-evoked responses in both L29 interneurons and LFS motor neurons. We further show that this form of inhibition is transient, having a time course of approximately 60 sec. Finally, we directly tested the role of the L30s in mediating this form of inhibition by hyperpolarizing two (of three) L30 interneurons during tail stimulation. L30 inactivation significantly attenuated tail stimulation-induced inhibition of siphon-evoked input to both L29 interneurons and LFS motor neurons. Based on these results, we suggest that L30-potentiated inhibition may have an important adaptive role in optimizing the signal-to-noise ratio for activation of the SWR circuit by providing stabilization of SWR responsiveness under a wide range of environmental conditions.

  12. Technology transfer opportunities: partnership opportunities available at the USGS

    USGS Publications Warehouse

    ,

    1996-01-01

    The following are USGS research projects offering an opportunity for Cooperative Research and Development Agreement (CRADA) partnerships. A CRADA is an agreement between one or more Federal agencies and one or more non-Federal agencies to work together in research or developmental activities. CRADAs permit both partners to share information in a protected environment and offer incentives to the non-Federal partner(s) to commercialize the resulting product of the effort.

  13. A new UK Greenhouse Gas measurement network providing ultra high-frequency measurements of key radiatively active trace gases taken from a network of tall towers

    NASA Astrophysics Data System (ADS)

    Grant, A.; O'Doherty, S.; Manning, A. J.; Simmonds, P. G.; Derwent, R. G.; Moncrieff, J. B.; Sturges, W. T.

    2012-04-01

    Monitoring of atmospheric concentrations of gases is important in assessing the impact of international policies related to the atmospheric environment. The effects of control measures on greenhouse gases introduced under the Montreal and Kyoto Protocols are now being observed. Continued monitoring is required to assess the overall success of the Protocols. For over 15 years the UK Government have funded high-frequency measurements of greenhouse gases and ozone depleting gases at Mace Head, a global background measurement station on the west coast of Ireland. These continuous, high-frequency, high-precision measurements are used to estimate regional (country-scale) emissions of greenhouse gases across the UK using an inversion methodology (NAME-Inversion) that links the Met Office atmospheric dispersion model (Numerical Atmospheric dispersion Modelling Environment - NAME) with the Mace Head observations. This unique inversion method acts to independently verify bottom up emission estimates of radiatively active and ozone-depleting trace gases. In 2011 the UK government (DECC) funded the establishment and integration of three new tall tower measurements stations in the UK, to provide enhanced resolution emission maps and decrease uncertainty of regional emission estimates produced using the NAME-Inversion. One station included in this new UK network was already established in Scotland and was used in collaboration with Edinburgh University. The two other new stations are in England and were set-up early in 2012, they contain brand new instrumentation for measurements of greenhouse gases. All three additional stations provide ultra high-frequency (1 sec) data of CO2 and CH4 using the Picarro© Cavity Ring Down Spectrometer and high frequency (20 min) measurements of N2O and SF6 from custom built sample modules with GC-ECD. We will present the new tall tower UK measurement network in detail. Using high-frequency measurements at new operational sites, including Mace

  14. American Indial Educational Opportunities Program at Hampton University

    NASA Technical Reports Server (NTRS)

    Molin, Paulette F.

    1999-01-01

    The American Indian Educational Opportunities Program (AIEOP) at Hampton University was formed to provide scholarship and other support to eligible students from state and federally recognized tribal groups on campus. During the reporting period, AIEOP worked to enhance American Indian participation at Hampton through a variety of means, including recruitment and retention of students, outreach activities, curatorial efforts, course instruction, and sponsorship of educational programs. Dr. Paulette F. Molin, a member of the Minnesota Chippewa Tribe, served as the program's director.

  15. An Opportunity to Rise

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image shows the Mars Exploration Rover Opportunity's wheels in their stowed configuration. As of 9:00 a.m. January 28, 2004, the rover had deployed its wheels and completed the first half of the stand-up process. This image was taken at Opportunity's landing site, Meridiani Planum, by the hazard-identification camera.

  16. Lunar Exploration and Science Opportunities in ESA

    NASA Astrophysics Data System (ADS)

    Carpenter, J.; Houdou, B.; Fisackerly, R.; De Rosa, D.; Schiemann, J.; Patti, B.; Foing, B.

    2014-04-01

    ESA seeks to provide Europe with access to the lunar surface, and allow Europeans to benefit from the opening up of this new frontier, as part of a global endeavour. This will be best achieved through an exploration programme which combines the strengths and capabilities of both robotic and human explorers. ESA is preparing for future participation in lunar exploration through a combination of human and robotic activities, in cooperation with international partners. Future planned activities include the contribution of key technological capabilities to the Russian led robotic missions, Luna-Glob, Luna-Resurs orbiter and Luna-Resurs lander. For the Luna-Resurs lander ESA will provide analytical capabilities to compliment the already selected Russian led payload, focusing on the composition and isotopic abundances of lunar volatiles in polar regions. This should be followed by the contributions at the level of mission elements to a Lunar Polar Sample Return mission. This partnership will provide access for European investigators to the opportunities offered by the Russian led instruments on the missions, as well as providing Europe with a unique opportunity to characterize and utilize polar volatile populations. Ultimately samples of high scientific value, from as of yet unexplored and unsampled locations shall be made available to the scientific community. These robotic activities are being performed with a view to enabling a future more comprehensive programme in which robotic and human activities are integrated to provide the maximum benefits from lunar surface access. Activities on the ISS and ESA participation to the US led Multi-Purpose Crew Vehicle, which is planned for a first unmanned lunar flight in 2017, are also important steps towards achieving this. All of these activities are performed with a view to generating the technologies, capabilities, knowledge and heritage that will make Europe an indispensible partner in the exploration missions of the future

  17. Structure and Activity Analyses of Escherichia coli K-12 NagD Provide Insight into the Evolution of Biochemical Function in the Haloakanoic Acid Dehlogenase Superfamily

    SciTech Connect

    Tremblay,L.; Dunaway-Mariano, D.; Allen, K.

    2006-01-01

    The HAD superfamily is a large superfamily of proteins which share a conserved core domain that provides those active site residues responsible for the chemistry common to all family members. The superfamily is further divided into the four subfamilies I, IIA, IIB, and III, based on the topology and insertion site of a cap domain that provides substrate specificity. This structural and functional division implies that members of a given HAD structural subclass may target substrates that have similar structural characteristics. To understand the structure/function relationships in all of the subfamilies, a type IIA subfamily member, NagD from Escherichia coli K-12, was selected (type I, IIB, and III members have been more extensively studied). The structure of the NagD protein was solved to 1.80 Angstroms with R{sub work} = 19.8% and R{sub free} = 21.8%. Substrate screening and kinetic analysis showed NagD to have high specificity for nucleotide monophosphates with kcat/Km = 3.12 x 10{sup 4} and 1.28 x 10{sup 4} {micro}M{sup -1} s{sup -1} for UMP and GMP, respectively. This specificity is consistent with the presence of analogues of NagD that exist as fusion proteins with a nucleotide pyrophosphatase from the Nudix family. Docking of the nucleoside substrate in the active site brings it in contact with conserved residues from the cap domain that can act as a substrate specificity loop (NagD residues 144-149) in the type IIA subfamily. NagD and other subfamily IIA and IIB members show the common trait that substrate specificity and catalytic efficiencies (k{sub cat}/K{sub m}) are low (1 x 10{sup 4} M{sup -1} s{sup -1}) and the boundaries defining physiological substrates are somewhat overlapping. The ability to catabolize other related secondary metabolites indicates that there is regulation at the genetic level.

  18. Office of Equal Opportunity Programs

    NASA Technical Reports Server (NTRS)

    Chin, Jennifer L.

    2004-01-01

    The NASA Glenn Office of Equal Opportunity Programs works to provide quality service for all programs and/or to assist the Center in becoming a model workplace. During the summer of 2004, I worked with Deborah Cotleur along with other staff members to create and modify customer satisfaction surveys. This office aims to assist in developing a model workplace by providing functions as a change agent to the center by serving as an advisor to management to ensure equity throughout the Center. In addition, the office serves as a mediator for the Center in addressing issues and concerns. Lastly, the office provides assistance to employees to enable attainment of personal and organizational goals. The Office of Equal Opportunities is a staff office which reports and provides advice to the Center Director and Executive Leadership, implements laws, regulations, and presidential executive orders, and provides center wide leadership and assistance to NASA GRC employees. Some of the major responsibilities of the office include working with the discrimination complaints program, special emphasis programs (advisory groups), management support, monitoring and evaluation, contract compliance, and community outreach. During my internship in this office, my main objective was to create four customer satisfaction surveys based on EO retreats, EO observances, EO advisory boards, and EO mediation/counseling. I created these surveys after conducting research on past events and surveys as well as similar survey research created and conducted by other NASA centers, program for EO Advisory group members, leadership training sessions for supervisors, preventing sexual harassment training sessions, and observance events. I also conducted research on the style and format from feedback surveys from the Marshall Equal Opportunity website, the Goddard website, and the main NASA website. Using the material from the Office of Equal Opportunity Programs at Glenn Research Center along with my

  19. Low-dose ionizing radiation induces direct activation of natural killer cells and provides a novel approach for adoptive cellular immunotherapy.

    PubMed

    Yang, Guozi; Kong, Qingyu; Wang, Guanjun; Jin, Haofan; Zhou, Lei; Yu, Dehai; Niu, Chao; Han, Wei; Li, Wei; Cui, Jiuwei

    2014-12-01

    Recent evidence indicates that limited availability and cytotoxicity have restricted the development of natural killer (NK) cells in adoptive cellular immunotherapy (ACI). While it has been reported that low-dose ionizing radiation (LDIR) could enhance the immune response in animal studies, the influence of LDIR at the cellular level has been less well defined. In this study, the authors aim to investigate the direct effects of LDIR on NK cells and the potential mechanism, and explore the application of activation and expansion of NK cells by LDIR in ACI. The authors found that expansion and cytotoxicity of NK cells were markedly augmented by LDIR. The levels of IFN-γ and TNF-α in the supernatants of cultured NK cells were significantly increased after LDIR. Additionally, the effect of the P38 inhibitor (SB203580) significantly decreased the expanded NK cell cytotoxicity, cytokine levels, and expression levels of FasL and perforin. These findings indicate that LDIR induces a direct expansion and activation of NK cells through possibly the P38-MAPK pathway, which provides a potential mechanism for stimulation of NK cells by LDIR and a novel but simplified approach for ACI.

  20. Promotion of health-enhancing physical activity in rheumatoid arthritis: a comparative study on healthcare providers in Italy, The Netherlands and Sweden.

    PubMed

    Brodin, Nina; Hurkmans, Emalie; DiMatteo, Luigi; Nava, Tiziana; Vliet Vlieland, Thea; Opava, Christina H

    2015-10-01

    The objectives of this study were to compare attitudes, practice of advice, perceived competencies and educational needs related to health-enhancing physical activity (HEPA) in rheumatoid arthritis (RA) among Dutch, Italian and Swedish healthcare providers (HCP) and to explore associations between these factors and age, gender and HEPA levels of HCP. Questionnaires were sent to 2939 HCP, members of their national rheumatology organizations. HEPA was assessed with the Short Questionnaire to Assess Health-Enhancing Physical Activity or the International Physical Activity Questionnaire; attitudes, practice of advice, perceived competencies and educational needs with a 23-item questionnaire. Overall response rate was 33 %. Ninety-five percent of HCP agreed that HEPA is an important health goal in RA. More Swedish HCP had positive attitudes to the attainability and safety of HEPA in RA. There were no differences between countries in practice of advice on HEPA to patients with RA in general or to those with recent onset disease, but more Italian HCP were reluctant to advise HEPA to patients with established disease. Of the total HCP, 36 to 60 % used public health guidelines to advise on HEPA, with Dutch HCP taking less advantage. Still they estimated a higher proportion of patients with RA to follow such advice. Italian HCP perceived their competencies the highest, but were also more interested in education to promote HEPA. Gender, age and HEPA performance had no association with attitudes toward HEPA, while a number of associations were found between these factors and practice of advice and perceived competencies. The differences found between HCP in the three countries might indicate the need for educational initiatives to improve HEPA promotion.

  1. The structure of Clostridium difficile toxin A glucosyltransferase domain bound to Mn2+ and UDP provides insights into glucosyltransferase activity and product release.

    PubMed

    D'Urzo, Nunzia; Malito, Enrico; Biancucci, Marco; Bottomley, Matthew J; Maione, Domenico; Scarselli, Maria; Martinelli, Manuele

    2012-09-01

    Clostridiumdifficile toxin A (TcdA) is a member of the large clostridial toxin family, and is responsible, together with C. difficile toxin B (TcdB), for many clinical symptoms d ring human infections. Like other large clostridial toxins, TcdA catalyzes the glucosylation of GTPases, and is able to inactivate small GTPases within the host cell. Here, we report the crystal structures of the TcdA glucosyltransferase domain (TcdA-GT) in the apo form and in the presence of Mn(2+) and hydrolyzed UDP-glucose. These structures, together with the recently reported crystal structure of TcdA-GT bound to UDP-glucose, provide a detailed understanding of the conformational changes of TcdA that occur during the catalytic cycle. Indeed, we present a new intermediate conformation of a so-called 'lid' loop (residues 510-522 in TcdA), concomitant with the absence of glucose in the catalytic domain. The recombinant TcdA was expressed in Brevibacillus in the inactive apo form. High thermal stability of wild-type TcdA was observed only after the addition of both Mn(2+) and UDP-glucose. The glucosylhydrolase activity, which is readily restored after reconstitution with both these cofactors, was similar to that reported for TcdB. Interestingly, we found that ammonium, like K(+) , is able to activate the UDP-glucose hydrolase activities of TcdA. Consequently, the presence of ammonium in the crystallization buffer enabled us to obtain the first crystal structure of TcdA-GT bound to the hydrolysis product UDP.

  2. An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction.

    PubMed

    E, Guangqi; Drujon, Thierry; Correia, Isabelle; Ploux, Olivier; Guianvarc'h, Dominique

    2013-12-01

    We have produced and purified an active site mutant of the Escherichia coli cyclopropane fatty acid synthase (CFAS) by replacing the strictly conserved G236 within cyclopropane synthases, by a glutamate residue, which corresponds to E146 of the homologous mycolic acid methyltransferase, Hma, producing hydroxymethyl mycolic acids. The G236E CFAS mutant had less than 1% of the in vitro activity of the wild type enzyme. We expressed the G236E CFAS mutant in an E. coli (DE3) strain in which the chromosomal cfa gene had been deleted. After extraction of phospholipids and conversion into the corresponding fatty acid methyl esters (FAMEs), we observed the formation of cyclopropanated FAMEs suggesting that the mutant retained some of the normal activity in vivo. However, we also observed the formation of new C17 methyl-branched unsaturated FAMEs whose structures were determined using GC/MS and NMR analyses. The double bond was located at different positions 8, 9 or 10, and the methyl group at position 10 or 9. Thus, this new FAMEs are likely arising from a 16:1 acyl chain of a phospholipid that had been transformed by the G236E CFAS mutant in vivo. The reaction catalyzed by this G236E CFAS mutant thus starts by the methylation of the unsaturated acyl chain at position 10 or 9 yielding a carbocation at position 9 or 10 respectively. It follows then two competing steps, a normal cyclopropanation or hydride shift/elimination events giving different combinations of alkenes. This study not only provides further evidence that cyclopropane synthases (CSs) form a carbocationic intermediate but also opens the way to CSs engineering for the synthesis of non-natural fatty acids.

  3. A unique horizontal gene transfer event has provided the octocoral mitochondrial genome with an active mismatch repair gene that has potential for an unusual self-contained function

    PubMed Central

    2011-01-01

    Background The mitochondrial genome of the Octocorallia has several characteristics atypical for metazoans, including a novel gene suggested to function in DNA repair. This mtMutS gene is favored for octocoral molecular systematics, due to its high information content. Several hypotheses concerning the origins of mtMutS have been proposed, and remain equivocal, although current weight of support is for a horizontal gene transfer from either an epsilonproteobacterium or a large DNA virus. Here we present new and compelling evidence on the evolutionary origin of mtMutS, and provide the very first data on its activity, functional capacity and stability within the octocoral mitochondrial genome. Results The mtMutS gene has the expected conserved amino acids, protein domains and predicted tertiary protein structure. Phylogenetic analysis indicates that mtMutS is not a member of the MSH family and therefore not of eukaryotic origin. MtMutS clusters closely with representatives of the MutS7 lineage; further support for this relationship derives from the sharing of a C-terminal endonuclease domain that confers a self-contained mismatch repair function. Gene expression analyses confirm that mtMutS is actively transcribed in octocorals. Rates of mitochondrial gene evolution in mtMutS-containing octocorals are lower than in their hexacoral sister-group, which lacks the gene, although paradoxically the mtMutS gene itself has higher rates of mutation than other octocoral mitochondrial genes. Conclusions The octocoral mtMutS gene is active and codes for a protein with all the necessary components for DNA mismatch repair. A lower rate of mitochondrial evolution, and the presence of a nicking endonuclease domain, both indirectly support a theory of self-sufficient DNA mismatch repair within the octocoral mitochondrion. The ancestral affinity of mtMutS to non-eukaryotic MutS7 provides compelling support for an origin by horizontal gene transfer. The immediate vector of transmission

  4. Cyberlearning for Climate Literacy: Challenges and Opportunities

    NASA Astrophysics Data System (ADS)

    McCaffrey, M. S.; Buhr, S. M.; Gold, A. U.; Ledley, T. S.; Mooney, M. E.; Niepold, F.

    2010-12-01

    Cyberlearning tools provide cost and carbon-efficient avenues for fostering a climate literate society through online engagement with learners. With climate change education becoming a Presidential Priority in 2009, funding for grants from NSF, NASA and NOAA is leading to a new generation of cyberlearning resources that supplement existing online resources. This paper provides an overview of challenges and opportunities relating to the online delivery of high quality, often complex climate science by examining several existing and emerging efforts, including the Climate Literacy and Energy Awareness Network (CLEAN,) a National Science Digital Library Pathway, the development by CIRES Education and Outreach of the Inspiring Climate Education Excellence (ICEE) online course, TERC’s Earth Exploration Toolbook (EET,) DataTools, and EarthLab modules, the NOAA Climate Stewards Education Program (CSEP) that utilizes the NSTA E-Learning Center, online efforts by members of the Federation of Earth Science Information Partners (ESIP), UCAR’s Climate Discovery program, and the Climate Adaptation, Mitigation e-Learning (CAMeL) project. In addition, we will summarize outcomes of the Cyberlearning for Climate Literacy workshop held in Washington DC in the Fall of 2009 and examine opportunities for teachers to develop and share their own lesson plans based on climate-related web resources that currently lack built-in learning activities, assessments or teaching tips.

  5. NEW OPPORTUNITIES IN GRAVITATIONAL MICROLENSING AND MESOLENSING

    NASA Astrophysics Data System (ADS)

    Di Stefano, Rosanne

    2014-06-01

    It took more than fifty years and the development of computer technology to transform Einstein's theoretical work on what we now call "gravitational microlensing" into an active and successful field of observational research. The first microlensing events were announced in 1993, and today's monitoring teams discover roughly 2000 candidate events each year. Binaries and planets have been discovered, and the masses of nearby stars and brown dwarfs have been measured. The total numbers of planets discovered through lensing is still small, but the field is young, and new methods and techniques are being developed. I will summarize the successes to date, and will then focus on some intriguing new opportunities. One of these opportunities is suggested by theoretical work that will allow observers to search for planets in a wider range of orbits, thereby increasing the discovery rate. Another opportunity is provided by counterpart searches and parallax signatures in the lensing light curves, which are helping us to identify those events caused by nearby lenses (mesolenses), located within about a kiloparsec. We can learn a great deal more about mesolenses, and therefore expect to systematically discover and measure masses of nearby brown dwarfs, neutron stars and black holes, and also to find nearby planets that can be be studied with other techniques as well. Finally, mesolensing events can be predicted in advance, providing a new avenue to measure the masses and multiplicity of nearby stars. Gravitational lensing events have a rich potential to contribute to astronomy, and we are presently exploring new possibilities and establishing the framework that will allow more of this potential to be realized.

  6. 21. Providence & Worchester RR: Freight house. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Providence & Worchester RR: Freight house. Providence, Providence Co., RI. Sec. 4119, mp 185.66 (See HAER no. RI-3 for further documentation on this site.) - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  7. UTBB FDSOI: Evolution and opportunities

    NASA Astrophysics Data System (ADS)

    Monfray, Stephane; Skotnicki, Thomas

    2016-11-01

    As today's 28 nm FDSOI (Fully Depleted Silicon On Insulator) technology is at the industrialization level, this paper aims to summarize the key advantages allowed by the thin BOX (Buried Oxide) of the FDSOI, through the technology evolution but also new opportunities, among logic applications and extending the possibilities offered by the platform. We will summarize how the advantages provided by the thin BOX have been first explored and developed, and how the back biasing techniques are the key to the outstanding performances provided by the FDSOI at low voltage. Then, as the FDSOI technology is also a solution to develop innovative platforms and applications, we will detail some opportunities. In particular, we will present monolithic 3D integration, ultra-low power devices for IoT (Internet of Things) and ultra-sensitive sensors.

  8. Genome-scale metabolic modeling to provide insight into the production of storage compounds during feast-famine cycles of activated sludge.

    PubMed

    Tajparast, Mohammad; Frigon, Dominic

    2013-01-01

    Studying storage metabolism during feast-famine cycles of activated sludge treatment systems provides profound insight in terms of both operational issues (e.g., foaming and bulking) and process optimization for the production of value added by-products (e.g., bioplastics). We examined the storage metabolism (including poly-β-hydroxybutyrate [PHB], glycogen, and triacylglycerols [TAGs]) during feast-famine cycles using two genome-scale metabolic models: Rhodococcus jostii RHA1 (iMT1174) and Escherichia coli K-12 (iAF1260) for growth on glucose, acetate, and succinate. The goal was to develop the proper objective function (OF) for the prediction of the main storage compound produced in activated sludge for given feast-famine cycle conditions. For the flux balance analysis, combinations of three OFs were tested. For all of them, the main OF was to maximize growth rates. Two additional sub-OFs were used: (1) minimization of biochemical fluxes, and (2) minimization of metabolic adjustments (MoMA) between the feast and famine periods. All (sub-)OFs predicted identical substrate-storage associations for the feast-famine growth of the above-mentioned metabolic models on a given substrate when glucose and acetate were set as sole carbon sources (i.e., glucose-glycogen and acetate-PHB), in agreement with experimental observations. However, in the case of succinate as substrate, the predictions depended on the network structure of the metabolic models such that the E. coli model predicted glycogen accumulation and the R. jostii model predicted PHB accumulation. While the accumulation of both PHB and glycogen was observed experimentally, PHB showed higher dynamics during an activated sludge feast-famine growth cycle with succinate as substrate. These results suggest that new modeling insights between metabolic predictions and population ecology will be necessary to properly predict metabolisms likely to emerge within the niches of activated sludge communities. Nonetheless

  9. GNAT Educational Opportunities

    NASA Astrophysics Data System (ADS)

    Culver, Roger B.; Craine, E. R.

    2006-12-01

    The GNAT MG1 Catalogue of Variable Stars contains some 26,000 new variable star entries, many of which are short period variable stars with periods of one day or less. This reservoir of GNAT data provides virtually limitless opportunities for a variety of publishable follow-up observational projects for student involvement at every educational level from middle school through upper division undergraduate college, In addition, analyses of the source images can be employed in a variety of student projects addressing issues such as photometric properties of the night sky and monitoring of sky brightness. To this end, we have developed protocols and software tools to help non-science majors to understand how science is done, and to assist science majors in gaining experience and publications that will help secure their professional futures. We have been fortunate to work with a number of students, representing several colleges and universities, who have helped establish and test pilot programs for these student projects. We describe a number of sample projects as well as several preliminary pilot projects which are currently in progress. Procedures for working with GNAT on these and other projects are also discussed.

  10. 7 CFR 622.6 - Equal opportunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of Agriculture (7 CFR Part 15), which provide that no person in the United States shall, on the... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.6 Equal opportunity. The Pub. L. 83-566 and...

  11. 7 CFR 622.6 - Equal opportunity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of Agriculture (7 CFR Part 15), which provide that no person in the United States shall, on the... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.6 Equal opportunity. The Pub. L. 83-566 and...

  12. 7 CFR 622.6 - Equal opportunity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of Agriculture (7 CFR Part 15), which provide that no person in the United States shall, on the... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.6 Equal opportunity. The Pub. L. 83-566 and...

  13. 7 CFR 622.6 - Equal opportunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of Agriculture (7 CFR Part 15), which provide that no person in the United States shall, on the... AGRICULTURE WATER RESOURCES WATERSHED PROJECTS General § 622.6 Equal opportunity. The Pub. L. 83-566 and...

  14. Wind Technologies and Evolving Opportunities (Presentation)

    SciTech Connect

    Robi Robichaud

    2014-03-01

    This presentation provides an overview of wind energy research being conducted at the National Wind Technology Center, market and technology trends in wind energy, and opportunities for wind technology.

  15. School-to-Work Opportunities for All Youth: Intermediary Organizations and Expanding Options. School-to-Work Intermediary Project. Issue Brief.

    ERIC Educational Resources Information Center

    Spera, Vincent; Williams, Andra

    The School to Work Opportunities Act of 1994 requires that all young people, including young people with disabilities and out-of-school youth, have equal opportunities to participate in the activities funded by it. Local intermediary organizations that provide a critical convening role and offer services to core education and business partners can…

  16. A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.

    PubMed

    Ernest, Sylvain; Rosa, Frédéric M

    2015-09-01

    MYO7A is an unconventional myosin involved in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and balance. Mutations of MYO7A are responsible for abnormal shaping of hair bundles, resulting in human deafness and murine deafness/circling behavior. Myo7aa, expressed in SHCs of the inner ear and lateral line of zebrafish, causes circling behavior and abnormal hair cell function when deficient in mariner mutant. This work identifies a new hair cell-specific enhancer, highly conserved between species, located within Intron 2-3 of zebrafish myosin 7a (myo7aa) gene. This enhancer is contained within a 761-bp DNA fragment that encompasses a newly identified Exon of myo7aa and whose activity does not depend on orientation. Compensation of mariner mutation by expression of mCherry-Myo7aa fusion protein under the control of this 761-bp DNA fragment results in recovery of balance, normal hair bundle shape and restored hair cell function. Two smaller adjacent fragments (344-bp and 431-bp), extracted from the 761-bp fragment, both show hair cell-specific enhancing activity, with apparently reduced intensity and coverage. These data should help understand the role of Myo7aa in sensory hair cell differentiation and function. They provide tools to decipher how myo7aa gene is expressed and regulated in SHCs by allowing the identification of potential transcription factors involved in this process. The discovered enhancer could represent a new target for the identification of deafness-causing mutations affecting human MYO7A.

  17. A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.

    PubMed

    Ernest, Sylvain; Rosa, Frédéric M

    2015-09-01

    MYO7A is an unconventional myosin involved in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and balance. Mutations of MYO7A are responsible for abnormal shaping of hair bundles, resulting in human deafness and murine deafness/circling behavior. Myo7aa, expressed in SHCs of the inner ear and lateral line of zebrafish, causes circling behavior and abnormal hair cell function when deficient in mariner mutant. This work identifies a new hair cell-specific enhancer, highly conserved between species, located within Intron 2-3 of zebrafish myosin 7a (myo7aa) gene. This enhancer is contained within a 761-bp DNA fragment that encompasses a newly identified Exon of myo7aa and whose activity does not depend on orientation. Compensation of mariner mutation by expression of mCherry-Myo7aa fusion protein under the control of this 761-bp DNA fragment results in recovery of balance, normal hair bundle shape and restored hair cell function. Two smaller adjacent fragments (344-bp and 431-bp), extracted from the 761-bp fragment, both show hair cell-specific enhancing activity, with apparently reduced intensity and coverage. These data should help understand the role of Myo7aa in sensory hair cell differentiation and function. They provide tools to decipher how myo7aa gene is expressed and regulated in SHCs by allowing the identification of potential transcription factors involved in this process. The discovered enhancer could represent a new target for the identification of deafness-causing mutations affecting human MYO7A. PMID:25556989

  18. Cotransformation of Trichoderma harzianum with β-Glucuronidase and Green Fluorescent Protein Genes Provides a Useful Tool for Monitoring Fungal Growth and Activity in Natural Soils†

    PubMed Central

    Bae, Yeoung-Seuk; Knudsen, Guy R.

    2000-01-01

    Trichoderma harzianum was cotransformed with genes encoding green fluorescent protein (GFP), β-glucuronidase (GUS), and hygromycin B (hygB) resistance, using polyethylene glycol-mediated transformation. One cotransformant (ThzID1-M3) was mitotically stable for 6 months despite successive subculturing without selection pressure. ThzID1-M3 morphology was similar to that of the wild type; however, the mycelial growth rate on agar was reduced. ThzID1-M3 was formed into calcium alginate pellets and placed onto buried glass slides in a nonsterile soil, and its ability to grow, sporulate, and colonize sclerotia of Sclerotinia sclerotiorum was compared with that of the wild-type strain. Wild-type and transformant strains both colonized sclerotia at levels above those of indigenous Trichoderma spp. in untreated controls. There were no significant differences in colonization levels between wild-type and cotransformant strains; however, the presence of the GFP and GUS marker genes permitted differentiation of introduced Trichoderma from indigenous strains. GFP activity was a useful tool for nondestructive monitoring of the hyphal growth of the transformant in a natural soil. The green color of cotransformant hyphae was clearly visible with a UV epifluorescence microscope, while indigenous fungi in the same samples were barely visible. Green-fluorescing conidiophores and conidia were observed within the first 3 days of incubation in soil, and this was followed by the formation of terminal and intercalary chlamydospores and subsequent disintegration of older hyphal segments. Addition of 5-bromo-4-chloro-3-indolyl-β-d-glucuronic acid (X-Gluc) substrate to recovered glass slides confirmed the activity of GUS as well as GFP in soil. Our results suggest that cotransformation with GFP and GUS can provide a valuable tool for the detection and monitoring of specific strains of T. harzianum released into the soil. PMID:10653755

  19. IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly.

    PubMed

    Pagnier, Adrien; Nicolet, Yvain; Fontecilla-Camps, Juan C

    2015-06-01

    Iron sulfur ([Fe-S]) clusters are essential prosthetic groups involved in fundamental cell processes such as gene expression regulation, electron transfer and Lewis acid base chemistry. Central components of their biogenesis are pyridoxal-5'-phosphate (PLP) dependent l-cysteine desulfurases, which provide the necessary S atoms for [Fe-S] cluster assembly. The archaeon Archaeoglobus fulgidus (Af) has two ORFs, which although annotated as l-cysteine desulfurases of the ISC type (IscS), lack the essential Lys residue (K199 in Af) that forms a Schiff base with PLP. We have previously determined the structure of an Af(IscU-D35A-IscS)2 complex heterologously expressed in Escherichia coli and found it to contain a [Fe2S2] cluster. In order to understand the origin of sulfide in that structure we have performed a series of functional tests using wild type and mutated forms of AfIscS. In addition, we have determined the crystal structure of an AfIscS-D199K mutant. From these studies we conclude that: i) AfIscS has no desulfurase activity; ii) in our in vitro [Fe2S2] cluster assembly experiments, sulfide ions are non-enzymatically generated by a mixture of iron, l-cysteine and PLP and iii) the physiological role of AfIscS may be to provide a cysteine ligand to the nascent cluster as observed in the [Fe2S2]-Af(IscU-D35A-IscS)2 complex. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases.

  20. Linking the SASSCAL WeatherNet and data management/rescue activities to provide consistent information for climate change assessments in Southern Africa

    NASA Astrophysics Data System (ADS)

    Helmschrot, J.; Kaspar, F.; Muche, G.; Hillmann, T.; Kanyanga, J.; Butale, M.; Nascimento, D.; Josenhans, K.; Falanga, E.; Neto, F. O. S.; Kruger, S.; Juergens, N.

    2014-12-01

    Many countries of Southern Africa face inadequate weather monitoring networks to provide reliable and consistent information for the development of efficient management strategies for sustainable water and land resources management, drought and flood risk analysis and forecasts as well as climate change impacts assessments. In addition, some existing networks are characterized by station data showing notable gaps in long-term observations. On the other hand, useful climate information is saved in historical documents and archives, but only barely explored up to now. Such documents are also available in archives of European meteorological services, partly also not yet in digital format. A main aim of the SASSCAL Initiative (Southern African Science Service Centre for Climate Change and Adaptive Land Management; www.sasscal.org) is to improve the availability of reliable meteorological baseline data along with a set of analytical methods to strengthen the research capacities in the SASSCAL region including Angola, Botswana, Namibia, South Africa and Zambia, and therewith to support and integrate information of existing national monitoring networks of the Southern African region. In close cooperation with the national weather authorities and various research institutions of the SASSCAL region, the above mentioned deficits are specifically addressed by i) extending the existing national monitoring networks through additional automatic weather stations and their integration in the SASSCAL WeatherNet which in near future hosts about 130 stations, ii) contributing to the development of Climate Data Management Systems (CDMS) at the national weather authorities in Angola, Botswana and Zambia and iii) the provision of additional time series of climate data based on the historic documents from various archives in all countries. The paper presents first results and shows how these efforts are linked to provide consistent climate information for Southern Africa in order to

  1. Expression analysis of genes encoding mitogen-activated protein kinases in maize provides a key link between abiotic stress signaling and plant reproduction.

    PubMed

    Sun, Wei; Chen, Hao; Wang, Juan; Sun, Hong Wei; Yang, Shu Ke; Sang, Ya Lin; Lu, Xing Bo; Xu, Xiao Hui

    2015-01-01

    Mitogen-activated protein kinases (MAPKs) play important roles in stress responses and development in plants. Maize (Zea mays), an important cereal crop, is a model plant species for molecular studies. In the last decade, several MAPKs have been identified in maize; however, their functions have not been studied extensively. Genome-wide identification and expression analysis of maize MAPK genes could provide valuable information for understanding their functions. In this study, 20 non-redundant maize MAPK genes (ZmMPKs) were identified via a genome-wide survey. Phylogenetic analysis of MAPKs from maize, rice (Oryza sativa), Arabidopsis (Arabidopsis thaliana), poplar (Populus trichocarpa), and tomato (Solanum lycopersicum) classified them into four major classes. ZmMPKs in the same class had similar domains, motifs, and genomic structures. Gene duplication investigations suggested that segmental duplications made a large contribution to the expansion of ZmMPKs. A number of cis-acting elements related to plant development and response to stress and hormones were identified in the promoter regions of ZmMPKs. Furthermore, transcript profile analysis in eight tissues and organs at various developmental stages demonstrated that most ZmMPKs were preferentially expressed in reproductive tissues and organs. The transcript abundance of most ZmMPKs changed significantly under salt, drought, cold, or abscisic acid (ABA) treatments, implying that they might participate in abiotic stress and ABA signaling. These expression analyses indicated that ZmMPKs might serve as linkers between abiotic stress signaling and plant reproduction. Our data will deepen our understanding of the complexity of the maize MAPK gene family and provide new clues to investigate their functions.

  2. HIV testing among sexually active Hispanic/Latino MSM in Miami-Dade County and New York City: opportunities for increasing acceptance and frequency of testing.

    PubMed

    Joseph, Heather A; Belcher, Lisa; O'Donnell, Lydia; Fernandez, M Isabel; Spikes, Pilgrim S; Flores, Stephen A

    2014-11-01

    HIV testing behavior is important in understanding the high rates of undiagnosed infection among Hispanic/Latino men who have sex with men (MSM). Correlates of repeat/recent testing (within the past year and ≥5 tests during lifetime) and test avoidance (never or >5 years earlier) were examined among 608 sexually active Hispanic/Latino MSM (Miami-Dade County and New York City). Those who reported repeat/recent testing were more likely to have incomes over $30,000, speak English predominately, and have visited and disclosed same-sex behavior to a health care provider (HCP) in the past year. Those who were classified as test avoiders were less likely to have incomes over $10,000 and to have seen an HCP in the past year. The main reason for not testing (in both groups) was fear of HIV positivity; however, twice as many test avoiders considered this their main reason, and more test avoiders had confidentiality concerns. Results suggest that messages to encourage testing among Hispanic/Latino MSM may be most effective if past testing patterns and reasons for not testing are considered. HCPs can play an important role by consistently offering HIV tests to MSM and tailoring messages based on prior testing histories.

  3. HIV testing among sexually active Hispanic/Latino MSM in Miami-Dade County and New York City: opportunities for increasing acceptance and frequency of testing.

    PubMed

    Joseph, Heather A; Belcher, Lisa; O'Donnell, Lydia; Fernandez, M Isabel; Spikes, Pilgrim S; Flores, Stephen A

    2014-11-01

    HIV testing behavior is important in understanding the high rates of undiagnosed infection among Hispanic/Latino men who have sex with men (MSM). Correlates of repeat/recent testing (within the past year and ≥5 tests during lifetime) and test avoidance (never or >5 years earlier) were examined among 608 sexually active Hispanic/Latino MSM (Miami-Dade County and New York City). Those who reported repeat/recent testing were more likely to have incomes over $30,000, speak English predominately, and have visited and disclosed same-sex behavior to a health care provider (HCP) in the past year. Those who were classified as test avoiders were less likely to have incomes over $10,000 and to have seen an HCP in the past year. The main reason for not testing (in both groups) was fear of HIV positivity; however, twice as many test avoiders considered this their main reason, and more test avoiders had confidentiality concerns. Results suggest that messages to encourage testing among Hispanic/Latino MSM may be most effective if past testing patterns and reasons for not testing are considered. HCPs can play an important role by consistently offering HIV tests to MSM and tailoring messages based on prior testing histories. PMID:24920606

  4. Career Opportunities in Physiology.

    ERIC Educational Resources Information Center

    Physiologist, 1984

    1984-01-01

    Physiologists offer their viewpoints on career opportunities in the pharmaceutical industries. A director's and an employee's views of what a director of pharmacology looks for in a physiologist are included. (JN)

  5. Opportunities with thermoplastics.

    PubMed

    Vaahs, Tilo

    2003-04-01

    Whether as substitutes for glass and metal, or completely novel injection moulded applications, engineering polymers offer a range of opportunities for developing cost-effective, safe and smart medical devices.

  6. Opportunity Spies Its Backshell

    NASA Technical Reports Server (NTRS)

    2004-01-01

    From its new location at the inner edge of the small crater surrounding it, the Mars Exploration Rover Opportunity was able to look out to the plains where its backshell (left) and parachute (right) landed. Opportunity is currently investigating a rock outcropping with its suite of robotic geologic tools. This approximate true-color image was created by combining data from the panoramic camera's red, green and blue filters.

  7. Aerobic Production and Utilization of Lactate Satisfy Increased Energy Demands Upon Neuronal Activation in Hippocampal Slices and Provide Neuroprotection Against Oxidative Stress

    PubMed Central

    Schurr, Avital; Gozal, Evelyne

    2012-01-01

    Ever since it was shown for the first time that lactate can support neuronal function in vitro as a sole oxidative energy substrate, investigators in the field of neuroenergetics have been debating the role, if any, of this glycolytic product in cerebral energy metabolism. Our experiments employed the rat hippocampal slice preparation with electrophysiological and biochemical methodologies. The data generated by these experiments (a) support the hypothesis that lactate, not pyruvate, is the end-product of cerebral aerobic glycolysis; (b) indicate that lactate plays a major and crucial role in affording neural tissue to respond adequately to glutamate excitation and to recover unscathed post-excitation; (c) suggest that neural tissue activation is accompanied by aerobic lactate and NADH production, the latter being produced when the former is converted to pyruvate by mitochondrial lactate dehydrogenase (mLDH); (d) imply that NADH can be utilized as an endogenous scavenger of reactive oxygen species (ROS) to provide neuroprotection against ROS-induced neuronal damage. PMID:22275901

  8. El Niño-Southern Oscillation influence on the dust storm activity in Australia: Can the past provide a key to the future?

    NASA Astrophysics Data System (ADS)

    Pudmenzky, C.; Stone, R.; Allan, R.; Butler, H.

    2011-12-01

    impacts on rural communities. All major continental scale dust storm events have occurred after periods of prolonged drought. The reconstruction of the ENSO history using longer-term meteorological data, historical records, and other proxy data that may otherwise have been available provides a far more lengthy and detailed global picture of past ENSO and other climate variability thereby allowing recent climate variability to be assessed from a long-term "multi-proxy" perspective. The resulting dataset can be used to better understand the range of past, present and future climate variability and the influence these have on the dust storm activity in Australia. In addition the information gained can provide an independent means of verifying climate model simulations. The scientific community is well aware that climate change is happening to some degree and Australia is already starting to experience the effects. In order to employ adaptation and mitigating measures it is necessary to understand the underlying mechanisms responsible for climate change.

  9. Pollution prevention opportunity assessments at Hanford

    SciTech Connect

    Betsch, M.D., Westinghouse Hanford

    1996-06-26

    The Pollution Prevention Opportunity Assessment (PPOA) is a pro- active way to look at a waste generating activity and identify opportunities to minimize wastes through a cost benefit analysis. Hanford`s PPOA process is based upon the graded approach developed by the Kansas City Plant. Hanford further streamlined the process while building in more flexibility for the individual users. One of the most challenging aspects for implementing the PPOA process at Hanford is one overall mission which is environmental restoration, Now that the facilities are no longer in production, each has a different non- routine activity making it difficult to quantify the inputs and outputs of the activity under consideration.

  10. 48 CFR 52.222-26 - Equal Opportunity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Equal Opportunity. 52.222... Equal Opportunity. As prescribed in 22.810(e), insert the following clause: Equal Opportunity (MAR 2007... particular religion to perform work connected with the carrying on of the Contractor's activities (41 CFR...

  11. 10 CFR 1040.8 - Effect of employment opportunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Effect of employment opportunity. 1040.8 Section 1040.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR ACTIVITIES General Provisions § 1040.8 Effect of employment opportunity. Due to limited opportunities in...

  12. EUFAR training opportunities to advance European airborne research

    NASA Astrophysics Data System (ADS)

    Reusen, I.; Brenguier, J.-L.; Brown, P.; Wendish, M.

    2009-04-01

    EUFAR, EUropean Facilities for Airborne Research, is an FP7 project (http://www.eufar.net) funded by the European Commission with 33 partners that aims at providing and improving the access to European airborne facilities (i.e. aircraft, airborne instruments, data processing centres) for researchers in environmental and geo-sciences through Networking Activities, Transnational Access and Joint Research Activities. This paper reports on the training opportunities within EUFAR for European researchers. In EUFAR three types of training opportunities are offered: 1) Participate in training courses (ET-TC) 2) Join an existing field campaign (ET-EC) 3) Participate in the design of a new field campaign (ET-TA), in the frame of EUFAR Transnational Access and tutored by more experienced researchers. During the 4-year EUFAR project (2008-2012), 4 training courses covering the complete chain from acquisition to interpretation of airborne data and images will be organised during spring/summer for early-stage researchers as well as university lecturers (new in FP7 EUFAR) in airborne research. The training courses will have an equal focus on theory and practical training/demonstration and each training course will be accompanied by a "student" airborne field campaign. Participants will be trained by top-class scientists, aircraft and/or instrument operators and each participant will get the opportunity to design his/her own experiment and to participate to that flight experiment. Furthermore, researchers have the opportunity to join an existing field campaign and work with more experienced researchers, aircraft and/or instrument operators. The list of airborne field campaigns open to join and the eligibility criteria, can be consulted at the EUFAR website. Finally, researchers have the opportunity to participate in the design of a new field campaign in the frame of EUFAR Transnational Access (TA). TA provides access to either aircraft or instrumentation that are not otherwise

  13. Disaster research: a nursing opportunity.

    PubMed

    Giarratano, Gloria; Savage, Jane; Barcelona-deMendoza, Veronica; Harville, Emily W

    2014-09-01

    Nurses working or living near a community disaster have the opportunity to study health-related consequences to disaster or disaster recovery. In such a situation, the researchers need to deal with the conceptual and methodological issues unique to postdisaster research and know what resources are available to guide them, even if they have no specialized training or previous experience in disaster research. The purpose of this article is to review issues and challenges associated with conducting postdisaster research and encourage nurses to seek resources and seize opportunities to conduct research should the situation arise. Current disaster studies and the authors' personal experiences conducting maternal-child research in post-Katrina New Orleans (2005-2013) provide real-life examples of how health professionals and nurses faced the challenges of doing postdisaster research. After catastrophic events, nurses need to step forward to conduct disaster research that informs and improves future disaster planning and healthcare responses.

  14. Opportunities for NASA Aerospace Related Funding and Collaboration

    NASA Technical Reports Server (NTRS)

    Miranda, Felix A.

    2005-01-01

    This presentation describes the different opportunities that NASA offers for effective collaboration with Academia and Industry. In particular, the presentation includes a general overview of opportunities such as SBIRs, STTRs, Educational Programs and NASA Research Announcements. A general description of forthcoming competitive opportunities under the Exploration Systems Mission Directorate (ESMD) as well as the Science Mission Directorate (SMD) are also provided.

  15. 42 CFR 405.809 - Opportunity to submit evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Opportunity to submit evidence. 405.809 Section 405... Program § 405.809 Opportunity to submit evidence. The parties to the review (as provided for in § 405.807(a)) shall have a reasonable opportunity to submit written evidence and contentions as to fact or...

  16. 42 CFR 405.809 - Opportunity to submit evidence.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Opportunity to submit evidence. 405.809 Section 405... Program § 405.809 Opportunity to submit evidence. The parties to the review (as provided for in § 405.807(a)) shall have a reasonable opportunity to submit written evidence and contentions as to fact or...

  17. Overview of Space Science and Information Research Opportunities at NASA

    NASA Technical Reports Server (NTRS)

    Green, James L.

    2000-01-01

    It is not possible to review all the opportunities that NASA provides to support the Space Science Enterprise, in the short amount of time allotted for this presentation. Therefore, only a few key programs will be discussed. The programs that I will discuss will concentrate on research opportunities for faculty, graduate and postdoctoral candidates in Space Science research and information technologies at NASA. One of the most important programs for research opportunities is the NASA Research Announcement or NRA. NASA Headquarters issues NRA's on a regular basis and these cover space science and computer science activities relating to NASA missions and programs. In the Space Sciences, the most important NRA is called the "Research Opportunities in Space Science or the ROSS NRA. The ROSS NRA is composed of multiple announcements in the areas of structure and evolution of the Universe, Solar System exploration, Sun-Earth connections, and applied information systems. Another important opportunity is the Graduate Student Research Program (GSRP). The GSRP is designed to cultivate research ties between a NASA Center and the academic community through the award of fellowships to promising students in science and engineering. This program is unique since it matches the student's area of research interest with existing work being carried out at NASA. This program is for U.S. citizens who are full-time graduate students. Students who are successful have made the match between their research and the NASA employee who will act as their NASA Advisor/ Mentor. In this program, the student's research is primarily accomplished under the supervision of his faculty advisor with periodic or frequent interactions with the NASA Mentor. These interactions typically involve travel to the sponsoring NASA Center on a regular basis. The one-year fellowships are renewable for up to three years and over $20,000 per year. These and other important opportunities will be discussed.

  18. Group Family Day Care Provider Handbook

    ERIC Educational Resources Information Center

    New York State Office of Children and Family Services, 2006

    2006-01-01

    Group family day care providers need to create high-quality programs where children have opportunities to grow, learn and thrive. Part of providing high-quality child care includes complying with the group family day care regulations from the New York State Office of Children and Family Services (OCFS). This Handbook will help day care providers:…

  19. New drug discovery: extraordinary opportunities in an uncertain time.

    PubMed

    Kinch, Michael S; Flath, Richard

    2015-11-01

    The way in which new medicines are discovered has irreversibly changed and the future sustainability of the enterprise is characterized by an unprecedented period of uncertainty. Herein, we convey that these changes provide unprecedented opportunities for many different players within the private and public sectors to work together and develop new models that ensure the sustainability of activities that have had an extraordinary impact; in terms of promoting public health and driving economic value. Specific examples of experiments are provided to demonstrate some of the new thinking that will be needed to ensure continuation of new drug discovery. PMID:25528676

  20. Using the Concept of Zone of Proximal Development to Explore the Challenges of and Opportunities in Designing Discourse Activities Based on Practical Work

    ERIC Educational Resources Information Center

    Mestad, Idar; Kolstø, Stein Dankert

    2014-01-01

    This article reports a study in which two researchers collaborated with five teachers to facilitate discourse activities aimed to enhance students' learning from practical activities. The paper explores how certain teacher practices support or hinder students' learning. Four cases from the study were analyzed in depth using…