Science.gov

Sample records for activities provide opportunities

  1. PROVIDING ENRICHMENT OPPORTUNITIES THROUGH CAMPING AND OTHER SIMILAR ACTIVITIES (ELEMENTARY), SPRING 1966. PROGRAM EVALUATION.

    ERIC Educational Resources Information Center

    Milwaukee Public Schools, WI.

    OUTDOOR EDUCATION IN THE FORM OF DAY CAMPS, TEPEE CAMPS, THREE-DAY CAMPS, TEACHER-SELECTED FIELD TRIPS, AND A MOBILE NATURE MUSEUM WAS PROVIDED FOR CHILDREN FROM DEPRIVED AREAS. A TOTAL OF 11,680 CHILDREN FROM 44 ELEMENTARY, JUNIOR HIGH, AND HIGH SCHOOLS PARTICIPATED IN THE PROGRAM BETWEEN MAY 1, 1966 AND AUGUST 3, 1966. THE DAY AND OVER-NIGHT…

  2. Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities?

    PubMed

    Rovida, Elisabetta; Stecca, Barbara

    2015-12-01

    The Hedgehog-GLI (HH-GLI) signaling is of critical importance during embryonic development, where it regulates a number of cellular processes, including patterning, proliferation and differentiation. Its aberrant activation has been linked to several types of cancer. HH-GLI signaling is triggered by binding of ligands to the transmembrane receptor patched and is subsequently mediated by transcriptional effectors belonging to the GLI family, whose function is fine tuned by a series of molecular interactions and modifications. Several HH-GLI inhibitors have been developed and are in clinical trials. Similarly, the mitogen-activated protein kinases (MAPK) are involved in a number of biological processes and play an important role in many diseases including cancer. Inhibiting molecules targeting MAPK signaling, especially those elicited by the MEK1/2-ERK1/2 pathway, have been developed and are moving into clinical trials. ERK1/2 may be activated as a consequence of aberrant activation of upstream signaling molecules or during development of drug resistance following treatment with kinase inhibitors such as those for PI3K or BRAF. Evidence of a crosstalk between HH-GLI and other oncogenic signaling pathways has been reported in many tumor types, as shown by recent reviews. Here we will focus on the interaction between HH-GLI and the final MAPK effectors ERK1/2, p38 and JNK in cancer in view of its possible implications for cancer therapy. Several reports highlight the existence of a consistent crosstalk between HH signaling and MAPK, especially with the MEK1/2-ERK1/2 pathway, and this fact should be taken into consideration for designing optimal treatment and prevent tumor relapse.

  3. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Providing other economic... EMPLOYMENT AND BUSINESS OPPORTUNITY ECONOMIC OPPORTUNITIES FOR LOW- AND VERY LOW-INCOME PERSONS Economic Opportunities for Section 3 Residents and Section 3 Business Concerns § 135.40 Providing other...

  4. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Providing other economic... EMPLOYMENT AND BUSINESS OPPORTUNITY ECONOMIC OPPORTUNITIES FOR LOW- AND VERY LOW-INCOME PERSONS Economic Opportunities for Section 3 Residents and Section 3 Business Concerns § 135.40 Providing other...

  5. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Providing other economic... EMPLOYMENT AND BUSINESS OPPORTUNITY ECONOMIC OPPORTUNITIES FOR LOW- AND VERY LOW-INCOME PERSONS Economic Opportunities for Section 3 Residents and Section 3 Business Concerns § 135.40 Providing other...

  6. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Providing other economic... EMPLOYMENT AND BUSINESS OPPORTUNITY ECONOMIC OPPORTUNITIES FOR LOW- AND VERY LOW-INCOME PERSONS Economic Opportunities for Section 3 Residents and Section 3 Business Concerns § 135.40 Providing other...

  7. 24 CFR 135.40 - Providing other economic opportunities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Providing other economic... EMPLOYMENT AND BUSINESS OPPORTUNITY ECONOMIC OPPORTUNITIES FOR LOW- AND VERY LOW-INCOME PERSONS Economic Opportunities for Section 3 Residents and Section 3 Business Concerns § 135.40 Providing other...

  8. GEAR UP: Providing Opportunities or Conflict?

    ERIC Educational Resources Information Center

    Walsh, Rachael

    2008-01-01

    Since 1965 the federal government has attempted to provide low socioeconomic status students with equal access to postsecondary education through the Higher Education Act and its multiplicative programmatic efforts. Implemented as one such program in 1998, the Gaining Early Awareness and Readiness for Undergraduate Programs, or GEAR UP, has been…

  9. Physical activity opportunities in afterschool programs.

    PubMed

    Weaver, R Glenn; Beets, Michael W; Huberty, Jennifer; Freedman, Darcy; Turner-Mcgrievy, Gabrielle; Ward, Diane

    2015-05-01

    Afterschool programs (ASPs) have potential to provide children moderate to vigorous physical activity (MVPA). The availability and types (e.g., free play or organized activities) of physical activity opportunities, their structure (e.g., presence of lines, elimination games), and staff behaviors (e.g., encouragement, engaged) can influence children's MVPA. This study explored these factors in 20 ASPs serving over 1,700 elementary-age children. The occurrence, types, and structure of physical activity opportunities, and staff behaviors were collected via the SOSPAN (System for Observing Staff Promotion of Physical Activity and Nutrition). A total of 4,660 SOSPAN scans were completed across 63 complete program days (1,733 during physical activity opportunities). Physical activity opportunities were observed on 60 program days across all 20 sites, with 73% of those opportunities classified as free play. ASPs scheduled an average of 66.3 minutes (range 15-150 minutes) of physical activity opportunities daily. Games played included basketball, tag, soccer, and football. Staff rarely engaged in physical activity promotion behaviors, and the structure of organized games discouraged MVPA. For example, staff verbally promoted physical activity in just 6.1% of scans, while organized games were more likely to involve lines and elimination. Professional development training may enhance staffs' physical activity promotion and the structure of activity opportunities.

  10. Physical activity opportunities in afterschool programs

    PubMed Central

    Weaver, R. Glenn; Beets, Michael W.; Huberty, Jennifer; Freedman, Darcy; Turner-Mcgrievy, Gabrielle; Ward, Diane

    2015-01-01

    Afterschool programs (ASPs) have potential to provide children moderate-to-vigorous physical activity (MVPA). The availability and types (e.g., free play or organized activities) of physical activity opportunities, their structure (e.g., presence of lines, elimination games), and staff behaviors (e.g., encouragement, engaged) can influence children’s MVPA. This study explored these factors in 20 ASPs serving over 1,700 elementary-age children. The occurrence, types and structure of physical activity opportunities, and staff behaviors were collected via the System for Observing Staff Promotion of Physical Activity and Nutrition (SOSPAN). A total of 4,660 SOSPAN scans were completed across 63 complete program days (1733 during physical activity opportunities). Physical activity opportunities were observed on 60 program days across all 20 sites, with 73% of those opportunities classified as free play. ASPs scheduled an average of 66.3 minutes (range 15-150min) of physical activity opportunities daily. Games played included basketball, tag, soccer and football. Staff rarely engaged in physical activity promotion behaviors, and the structure of organized games discouraged MVPA. For example, staff verbally promoted physical activity in just 6.1% of scans, while organized games were more likely to involve lines and elimination. Professional development training may enhance staffs’ physical activity promotion and the structure of activity opportunities. PMID:25586132

  11. Physical Activity Opportunities before and after School

    ERIC Educational Resources Information Center

    Hastie, Peter A.

    2007-01-01

    This article addresses the many ways in which schools can provide physical activity opportunities for students by taking advantage of hours that students might otherwise spend waiting for school to begin or playing computer games after school has ended. The article presents creative strategies for engaging students in activities that are…

  12. Hydrogen PEM Fuel Cells: A Market Need Provides Research Opportunities

    SciTech Connect

    Payne, Terry L; Brown, Gilbert M; Bogomolny, David

    2010-01-01

    It has been said that necessity is the mother of invention. Another way this can be stated is that market demands create research opportunities. Because of the increasing demand for oil (especially for fueling vehicles utilizing internal combustion engines) and the fact that oil is a depleting (not renewable) energy source, a market need for a renewable source of energy has created significant opportunities for research. This paper addresses the research opportunities associated with producing a market competitive (i.e., high performance, low cost and durable) hydrogen proton exchange membrane (PEM) fuel cell. Of the many research opportunities, the primary ones to be addressed directly are: Alternative membrane materials, Alternative catalysts, Impurity effects, and Water transport. A status of Department of Energy-sponsored research in these areas will be summarized and the impact of each on the ability to develop a market-competitive hydrogen PEM fuel cell powered vehicle will be discussed. Also, activities of the International Partnership for the Hydrogen Economy in areas such as advanced membranes for fuel cells and materials for storage will be summarized.

  13. Precision medicine: opportunities, possibilities, and challenges for patients and providers.

    PubMed

    Adams, Samantha A; Petersen, Carolyn

    2016-07-01

    Precision medicine approaches disease treatment and prevention by taking patients' individual variability in genes, environment, and lifestyle into account. Although the ideas underlying precision medicine are not new, opportunities for its more widespread use in practice have been enhanced by the development of large-scale databases, new methods for categorizing and representing patients, and computational tools for analyzing large datasets. New research methods may create uncertainty for both healthcare professionals and patients. In such situations, frameworks that address ethical, legal, and social challenges can be instrumental for facilitating trust between patients and providers, but must protect patients while not stifling progress or overburdening healthcare professionals. In this perspective, we outline several ethical, legal, and social issues related to the Precision Medicine Initiative's proposed changes to current institutions, values, and frameworks. This piece is not an exhaustive overview, but is intended to highlight areas meriting further study and action, so that precision medicine's goal of facilitating systematic learning and research at the point of care does not overshadow healthcare's goal of providing care to patients.

  14. Scientific advances provide opportunities to improve pediatric environmental health

    USGS Publications Warehouse

    Reddy, Michael M.; Reddy, Micaela B.; Reddy, Carol F.

    2004-01-01

    The health consequences of contaminants in the environment, with respect to the health of children and infants, recently have been dramatically brought to public attention by the motion pictures Erin Brockovich and A Civil Action. These productions focused public attention on the potential link between water contaminants and pediatric health, a continuing subject of public concern. As a consequence of the increasing production of new commercial chemicals, many chemicals have appeared in the scientific and public awareness as potential threats to health. These new or novel compounds eventually distribute in the environment and often are termed emerging contaminants. Gitterman and Bearer stated, "Children may serve as unwitting sentinels for society; they are often the youngest exposed to many environmental toxicants and may become the youngest in age to manifest adverse responses." The discipline of pediatric environmental health is still in its adolescence, but it will be increasingly important as new chemicals are generated and as more is learned about the health effects of chemicals already in commerce. Here, we provide an overview of recent advances in biomonitoring and environmental monitoring of environmental contaminants including emerging contaminants. Our purpose in writing this commentary is to make pediatricians aware of the current resources available for learning about pediatric environmental health and of ongoing research initiatives that provide opportunities to improve pediatric environmental health.

  15. Enhancing Academic Engagement: Providing Opportunities for Responding and Influencing Students to Choose to Respond

    ERIC Educational Resources Information Center

    Skinner, Christopher H.; Pappas, Danielle N.; Davis, Kai A.

    2005-01-01

    Although educators often provide opportunities for students to engage in active academic responding, in many situations, students either cannot or will not respond. In the current article, we analyze the reasons students fail to respond. Practical procedures educators can use to prevent "can't do" problems are provided. "Won't do" problems are…

  16. Offshore energy boom providing opportunities outside Medicare's umbrella.

    PubMed

    Robb, N

    1998-09-08

    Physicians upset by limits imposed by the medicare system are getting a chance to spread their entrepreneurial wings on the East Coast. A boom in offshore exploration, led by Newfoundland's massive Hibernia project, has led to numerous business opportunities for physicians.

  17. Mapping Pedagogical Opportunities Provided by Mathematics Analysis Software

    ERIC Educational Resources Information Center

    Pierce, Robyn; Stacey, Kaye

    2010-01-01

    This paper proposes a taxonomy of the pedagogical opportunities that are offered by mathematics analysis software such as computer algebra systems, graphics calculators, dynamic geometry or statistical packages. Mathematics analysis software is software for purposes such as calculating, drawing graphs and making accurate diagrams. However, its…

  18. Increasing opportunities for physical activity.

    PubMed

    Buckley, Sue

    2007-07-01

    Being physically active can have a number of benefits - having fun, meeting with friends, keeping healthy and experiencing success. For children with Down syndrome the foundations need to be laid early if they are to keep active in school, teenage and adult years and parents ask for more help in this area from professionals.

  19. Launching Science: Science Opportunities Provided by NASA's Constellation System

    NASA Technical Reports Server (NTRS)

    2008-01-01

    In 2004 NASA began implementation of the first phases of a new space exploration policy. This implementation effort included the development of a new human-carrying spacecraft, known as Orion; the Altair lunar lander; and two new launch vehicles, the Ares I and Ares V rockets.collectively called the Constellation System (described in Chapter 5 of this report). The Altair lunar lander, which is in the very preliminary concept stage, is not discussed in detail in the report. In 2007 NASA asked the National Research Council (NRC) to evaluate the science opportunities enabled by the Constellation System. To do so, the NRC established the Committee on Science Opportunities Enabled by NASA's Constellation System. In general, the committee interpreted "Constellation-enabled" broadly, to include not only mission concepts that required Constellation, but also those that could be significantly enhanced by Constellation. The committee intends this report to be a general overview of the topic of science missions that might be enabled by Constellation, a sort of textbook introduction to the subject. The mission concepts that are reviewed in this report should serve as general examples of kinds of missions, and the committee s evaluation should not be construed as an endorsement of the specific teams that developed the mission concepts or of their proposals. Additionally, NASA has a well-developed process for establishing scientific priorities by asking the NRC to conduct a "decadal survey" for a particular discipline. Any scientific mission that eventually uses the Constellation System will have to be properly evaluated by means of this decadal survey process. The committee was impressed with the scientific potential of many of the proposals that it evaluated. However, the committee notes that the Constellation System has been justified by NASA and selected in order to enable human exploration beyond low Earth orbit.not to enable science missions. Virtually all of the science

  20. Biosimilars: Opportunities to Promote Optimization Through Payer and Provider Collaboration.

    PubMed

    Manolis, Chronis H; Rajasenan, Kiran; Harwin, William; McClelland, Scott; Lopes, Maria; Farnum, Carolyn

    2016-09-01

    A panel was convened that consisted of 1 medical director, 2 pharmacy directors, and 2 oncologists, who represented the University of Pittsburgh Medical Center Health Plan, an integrated delivery network, and Florida Blue, a progressive regional health plan. This panel met in order to share ideas, discuss challenges, and develop practical solutions to promote optimal utilization in order to encourage collaboration between payers and providers to help ensure the success of biosimilar entrants into the marketplace. Live meetings were conducted in Orlando, Florida, and Pittsburgh, Pennsylvania, and were followed by virtual meetings to solidify ideas and concepts for this supplement. It is important for biosimilar manufacturers to identify potential payer, provider, and patient obstacles in order to develop strategic and tactical plans to preemptively address these potential obstacles. Gathering payer and provider insights will shed light on various issues such as access and reimbursement. Biosimilar manufacturers must be proactive in the education of payers, providers, and patients to ensure access to biosimilars. A strong factor emphasized among this group was that the assumption surrounding biosimilar development and use is the potential for health care cost savings. According to the panel, payers and providers must carefully consider economic implications and potential cost-effectiveness in order to increase the acceptance or understanding of biosimilars in clinical practice. The group identified 3 major challenges surrounding biosimilar adoption: (1) provider confidence in biosimilar education and clinical value, (2) provider confidence in reimbursement for new biosimilars, and (3) creating shared payer and provider cost-savings. After identification of the 3 challenges, the group posed potential solutions to help with biosimilar adoption.

  1. Vocabulary Learning through Reading: Does an ELT Course Book Provide Good Opportunities?

    ERIC Educational Resources Information Center

    Matsuoka, Warren; Hirsh, David

    2010-01-01

    This study investigates the vocabulary learning opportunities in an ELT course book designed for upper-intermediate learners. All the words appearing in the 12 chapters of the text were analyzed. The results suggest that the text would provide opportunities to deepen knowledge of the second 1,000 most frequent words in English, and would provide a…

  2. Active Play Opportunities at Child Care

    PubMed Central

    Saelens, Brian E.; Christakis, Dimitri A.

    2015-01-01

    BACKGROUND AND OBJECTIVES: Physical activity (PA) is important for children’s health and development, yet preschoolers are not meeting PA recommendations. The objective of this study was to examine different PA opportunities at child care and how variation in indoor versus outdoor and free versus teacher-led opportunities relate to children’s PA. METHODS: An observational study of 98 children (mean age 4.5 years, 49% girls) from 10 child care centers. Classrooms were observed for at least 4 full days per center (total 50 days) to categorize time into (1) not an active play opportunity (APO); (2) naptime; (3) APO, outdoor free play; (4) APO, outdoor teacher-led; (5) APO, indoor free play; and (6) APO, indoor teacher-led. Children wore accelerometers during observations. Linear regression models examined the influence of APO categories on moderate-vigorous physical activity (MVPA) and sedentary time. RESULTS: Children’s activity was 73% sedentary, 13% light, and 14% MVPA. For 88% of time children did not have APOs, including 26% time as naptime. On average, 48 minutes per day were APOs (41% sedentary, 18% light, and 41% MVPA), 33 minutes per day were outdoors. The most frequent APO was outdoor free play (8% of time); outdoor teacher-led time was <1%. Children were more active and less sedentary outdoors versus indoors and during the child-initiated APOs (indoors and outdoors) versus teacher-led APOs. CONCLUSIONS: Preschoolers were presented with significantly fewer than recommended opportunities for PA at child care. More APOs are needed for children to meet recommendations, particularly those that encourage more outdoor time, more teacher-led and child-initiated active play, and flexibility in naptime for preschoolers. PMID:25986016

  3. Improving Science and IT Literacy by Providing Urban-Based Environmental Science Research Opportunities

    NASA Astrophysics Data System (ADS)

    Cuff, K. E.; Corazza, L.; Liang, J.

    2007-12-01

    A U.C. Berkeley-based outreach program known as Environmental Science Information Technology Activities has been in operation over the past four years. The primary aim of the program is to provide opportunities for grades 9 and 10 students in diverse East San Francisco Bay Area communities to develop deeper understandings of the nature and conduct of science, which will increase their capacity to enroll and perform successfully in science, technology, engineering, and mathematics (STEM) courses in the future. Design of the program has been informed by recent research that indicates a close relationship between educational activities that promote the perception of STEM as being relevant and the ability to foster development of deeper conceptual understandings among teens. Accordingly, ESITA includes an important student-led environmental science research project component, which provides participants with opportunities to engage in research investigations that are directly linked to relevant, real-world environmental problems and issues facing their communities. Analysis of evidence gleaned from questionnaires, interviews with participants and specific assessment/evaluation instruments indicates that ESITA program activities, including after-school meetings, summer and school year research projects, and conference preparations and presentations has provided students with high-quality inquiry science experiences that increased their knowledge of STEM and IT concepts, as well as their understanding of the nature of the scientific enterprise. In addition, the program has achieved a high degree of success in that it has: enhanced participants' intellectual self-confidence with regard to STEM; developed deeper appreciation of how scientific research can contribute to the maintenance of healthy local environments; developed a greater interest in participating in STEM-related courses of study and after school programs; and improved attitudes toward STEM. Overall

  4. Agricultural Education: Key to Providing Broader Opportunities for Third World Women in Production Agriculture.

    ERIC Educational Resources Information Center

    Lelle, Mark A.; Holt, Barbara A.

    1987-01-01

    The authors focus on providing opportunities for women in Third World countries in agriculture. A review of the body of knowledge in agricultural development and of the issues surrounding current world food crises is included. (CH)

  5. Using Activity Theory to Understand Entrepreneurial Opportunity

    ERIC Educational Resources Information Center

    Holt, Robin

    2008-01-01

    Entrepreneurship is often described as the ability to recognize and exploit opportunities. Identifying opportunities is intentional and idiosyncratic insofar as they are recognized as opportunities is a novel and conscious event (otherwise the entrepreneur would be doing nothing new). Yet opportunities also have to be recognized by others as ones…

  6. New Generation of Military Members Provides Opportunity to Reform Military Benefits

    DTIC Science & Technology

    2013-03-01

    military to remain competitive requires a comprehensive approach. The generational characteristics of the Millennial generation should be considered when...proposing benefit reform. The values of the Millennial generational provide an opportunity to sustain front-loaded, family focused programs in exchange...challenges and need to compete for the service of the Millennial generation creates the impetus and opportunity to reform the current 20- year defined

  7. Individual Variability in Brain Activity: A Nuisance or an Opportunity?

    PubMed

    Van Horn, John Darrell; Grafton, Scott T; Miller, Michael B

    2008-12-01

    Functional imaging research has been heavily influenced by results based on population-level inference. However, group average results may belie the unique patterns of activity present in the individual that ordinarily are considered random noise. Recent advances in the evolution of MRI hardware have led to significant improvements in the stability and reproducibility of blood oxygen level dependent (BOLD) measurements. These enhancements provide a unique opportunity for closer examination of individual patterns of brain activity. Three objectives can be accomplished by considering brain scans at the individual level; (1) Mapping functional anatomy at a fine grained analysis; (2) Determining if an individual scan is normative with respect to a reference population; and (3) Understanding the sources of intersubject variability in brain activity. In this review, we detail these objectives, briefly discuss their histories and present recent trends in the analyses of individual variability. Finally, we emphasize the unique opportunities and challenges for understanding individual differences through international collaboration among Pacific Rim investigators.

  8. Windows to the Future: Can the United Nations Sustainable Development Goals Provide Opportunities for Nursing?

    PubMed

    Benton, David C; Ferguson, Stephanie L

    2016-01-01

    Windows of opportunity are wide open for the nursing profession to actively participate and engage in the policy implementation, evaluation, and achievement of the United Nations Sustainable Development Goals. Nurses bring valuable perspectives as members of diverse governance structures and offer a range of solutions that can help governments pursue and achieve the Sustainable Development Goals and targets by 2030.

  9. Instructional Design Strategies Used to Provide Equal Learning Opportunity for Deaf and Hard of Hearing Learners

    ERIC Educational Resources Information Center

    Mercado Cruz, Daniel

    2013-01-01

    Traditional classrooms are not being designed with deaf and hard of hearing learners in mind. Providing equal learning opportunities with the use of appropriate instructional design strategies to deaf and hard of hearing learners requires that instructional designers, faculty, and educational institutions understand what accommodations and…

  10. What Educational Opportunities Should Professionals in Aging Provide?: A Pilot Community Assessment

    ERIC Educational Resources Information Center

    Van Dussen, Daniel J.; Leson, Suzanne M.

    2010-01-01

    With the aging workforce and the increase of older adults, educational needs of the workforce in aging services are broadening. The pilot study used a survey to examine the types of educational opportunities and needs of professionals providing services to older adults in eastern Ohio and western Pennsylvania. Respondents (25.9%) reported learning…

  11. Providing Student Opportunities to Respond in Reading and Mathematics: A Look across Grade Levels

    ERIC Educational Resources Information Center

    Whitney, Todd; Cooper, Justin T.; Lingo, Amy S.

    2015-01-01

    The evidence for providing sufficient opportunities for students to respond has been established in terms of student engagement and achievement in reading and mathematics. Although supported by research, the question remains whether teachers are incorporating this effective practice in their classroom instruction. This study examines the analysis…

  12. Strengthening Family Capacity to Provide Young Children Everyday Natural Learning Opportunities

    ERIC Educational Resources Information Center

    Swanson, Jennifer; Raab, Melinda; Dunst, Carl J.

    2011-01-01

    A capacity-building approach to natural learning environment intervention practices was the focus of the study. Capacity-building early childhood intervention promotes parents' or other caregivers' skills, abilities, and confidence to provide children development-enhancing learning opportunities. Natural environment practices use everyday…

  13. Career Pathways and Gender Equity: Providing Opportunities for All Students. Ohio Vocational Sex Equity.

    ERIC Educational Resources Information Center

    Equity Issues, 1998

    1998-01-01

    Career pathways align vocational and academic education within career clusters and provide students new options from grades 9-14. They must have the following elements: industry breadth and depth; opportunities for many populations; career options at entry, technical, and professional levels; and alternative delivery options and academic and…

  14. Experiments, contingencies, and curriculum: Providing opportunities for learning through improvisation in science teaching

    NASA Astrophysics Data System (ADS)

    Kelly, Gregory J.; Brown, Candice; Crawford, Teresa

    2000-09-01

    In this article, we examine how, through discourse processes, a third grade teacher and her students come to situationally define science in their classroom. The teacher's use of particular discursive strategies promoted student talk, thus providing opportunities for students to learn about science through the exploration of a set of anomalous results in a life science experiment. Drawing from social studies of science, we used a discourse analytical approach to examine the classroom members' logic of experimentation, their explanations and scientific decisions, and their accounts of the events. These analyses allowed us to identify how particular teaching strategies afforded students opportunities to learn science concepts and about scientific processes.

  15. The Oregon health insurance experiment: when limited policy resources provide research opportunities.

    PubMed

    Allen, Heidi; Baicker, Katherine; Taubman, Sarah; Wright, Bill; Finkelstein, Amy

    2013-12-01

    In 2008 Oregon allocated access to its Medicaid expansion program, Oregon Health Plan Standard, by drawing names from a waiting list by lottery. The lottery was chosen by policy makers and stakeholders as the preferred way to allocate limited resources. At the same time, it also gave rise to the Oregon Health Insurance Experiment: an unprecedented opportunity to do a randomized evaluation - the gold standard in medical and scientific research - of the impact of expanding Medicaid. In this article we provide historical context for Oregon's decision to conduct a lottery, discuss the importance of randomized controlled designs for policy evaluation, and describe some of the practical challenges in successfully capitalizing on the research opportunity presented by the Oregon lottery through public-academic partnerships. Since policy makers will always face tough choices about how to distribute scarce resources, we urge thoughtful consideration of the opportunities to incorporate randomization that can substantially improve the evidence available to inform policy decisions without compromising policy goals.

  16. Youth physical activity opportunities in lower and higher income neighborhoods.

    PubMed

    Suminski, Richard Robert; Ding, Ding; Lee, Rebecca; May, Linda; Tota, Tonya; Dinius, David

    2011-08-01

    The presence of youth physical activity opportunities is one of the strongest environmental correlates of youth physical activity. More detailed information about such opportunities is needed to maximize their contributions to physical activity promotion especially in under resourced, lower income areas. The objectives of this study were to construct a comprehensive profile of youth physical activity opportunities and contrast profile characteristics between lower and higher income neighborhoods. Youth physical activity opportunities in eight lower (median household income <$36,000) and eight higher (>$36,000) income neighborhoods were identified and described using interviews, neighborhood tours, site visits, and systematic searches of various sources (e.g., Internet). Lower income neighborhoods had a greater number of locations offering youth physical activity opportunities but similar quantities of amenities. Lower income neighborhoods had more faith-based locations and court, trail/path, event, and water-type amenities. Higher income neighborhoods had significantly more for-profit businesses offering youth physical activity opportunities. Funding for youth physical activity opportunities in lower income neighborhoods was more likely to come from donations and government revenue (e.g., taxes), whereas the majority of youth physical activity opportunities in the higher income neighborhoods were supported by for-profit business revenue. Differences between lower and higher income neighborhoods in the type and amenities of youth physical activity opportunities may be driven by funding sources. Attention to these differences could help create more effective and efficient strategies for promoting physical activity among youth.

  17. Providing Opportunities for Deeper Learning. Findings from the Study of Deeper Learning Opportunities and Outcomes: Report 2

    ERIC Educational Resources Information Center

    Bitter, Catherine; Taylor, James; Zeiser, Kristina L.; Rickles, Jordan

    2014-01-01

    The "Study of Deeper Learning: Opportunities and Outcomes"--funded by the William and Flora Hewlett Foundation--aimed to determine whether students attending high schools with a mature and at least moderately well implemented approach to promoting deeper learning actually experienced greater deeper learning opportunities and outcomes…

  18. Better Together: Co-Location of Dental and Primary Care Provides Opportunities to Improve Oral Health.

    PubMed

    Pourat, Nadereh; Martinez, Ana E; Crall, James J

    2015-09-01

    Community Health Centers (CHCs) are one of the principal safety-net providers of health care for low-income and uninsured populations. Co-locating dental services in primary care settings provides an opportunity to improve access to dental care. Yet this study of California CHCs that provide primary care services shows that only about one-third of them co-located primary and dental care services on-site. An additional one-third were members of multisite organizations in which at least one other site provided dental care. The remaining one-third of CHC sites had no dental care capacity. Policy options to promote co-location include requiring on-site availability of dental services, providing infrastructure funding to build and equip dental facilities, and offering financial incentives to provide dental care and recruit dental providers.

  19. Improving Attitudes Toward STEM By Providing Urban-Based Environmental Science Research Opportunities

    NASA Astrophysics Data System (ADS)

    Cuff, K. E.; Molinaro, M.

    2005-12-01

    Over the past decade, numerous calls have been made for the need to increase the participation of the nation's underrepresented population in science, technology, engineering, and technology (STEM) fields of endeavor. A key element in improving the less than impressive conditions that now exist with regard to this issue, is the development of effective approaches that result in positive changes in young people's attitudes toward education in general, and STEM subject matter in particular during the early stages of their intellectual development. The Environmental Science Information Technology Activities (ESITA) program provides opportunities for under-represented grades 9 - 10 students in the East San Francisco Bay Area to learn about and apply key STEM concepts and related skills. Consisting of two-year-long after school programs at community center and school-based sites, as well as a Summer Research Institute, the ESITA program engages participants in a combination of STEM content learning activities and environmental science research projects that address issues relevant to their communities. Design of the ESITA program has been informed by: 1) pilot-study data that indicated key elements necessary for ensuring high levels of participant enthusiasm and interest; 2) a conceptual framework for development of instructional materials grounded in recent research about student learning of STEM content; and 3) research about effective after school programs that present academic content. Throughout the program's two-year existence, ESITA students have participated in the following projects: investigations of the distribution of elevated lead levels in drinking water samples from Washington, D.C.; air and water quality studies in and around a popular lake situated within the nation's oldest wildlife refuge, located in downtown Oakland, California; and studies of the relationship between airborne particulate matter concentrations in Richmond, California, and activity at

  20. Opportunities

    ERIC Educational Resources Information Center

    Estkowski, Terri

    2008-01-01

    In life, each person is offered opportunities, one after the other, until life ceases. For the author, one of those opportunities was to attend the Kalamazoo Area Mathematics and Science Center (KAMSC), an NCSSSMST school. While attending KAMSC as a member of its inaugural class required a bit of imagination regarding the opportunity at hand, and…

  1. Providing Children and Adolescents Opportunities for Social Interaction as a Standard of Care in Pediatric Oncology.

    PubMed

    Christiansen, Heather L; Bingen, Kristin; Hoag, Jennifer A; Karst, Jeffrey S; Velázquez-Martin, Blanca; Barakat, Lamia P

    2015-12-01

    Experiences with peers constitute an important aspect of socialization, and children and adolescents with cancer may experience reduced social interaction due to treatment. A literature review was conducted to investigate the evidence to support a standard of care evaluating these experiences. Sixty-four articles were reviewed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Moderate quality of evidence suggest that social interaction can be beneficial to increase knowledge, decrease isolation, and improve adjustment and constitute an important, unmet need. The evidence supports a strong recommendation for youth with cancer to be provided opportunities for social interaction following a careful assessment of their unique characteristics and preferences.

  2. Opportunities and Challenges for Water and Wastewater Industries to Provide Exchangeable Services

    SciTech Connect

    Sparn, Bethany; Hunsberger, Randolph

    2015-11-13

    Water and wastewater treatment plants and distribution systems use significant amounts of energy, around 2 - 4% of the total electricity used in the US, and their energy use is projected to increase as populations increase and regulations become more stringent. Water and wastewater systems have largely been disconnected from the electric utilities' efforts to improve energy efficiency and provide energy efficiency and provide grid services, likely because their core mission is to provide clean water and treated wastewater. Energy efficiency has slowly crept into the water and wastewater industry as the economic benefit has become more apparent, but there is still potential for significant improvement. Some of the larger, more progressive water utilities are starting to consider providing grid services; however, it remains a foreign concept to many. This report explores intrinsic mechanisms by which the water and wastewater industries can provide exchangeable services, the benefit to the parties involved, and the barriers to implementation. It also highlights relevant case studies and next steps. Although opportunities for increasing process efficiencies are certainly available, this report focuses on the exchangeable services that water and wastewater loads can provide to help maintain grid reliability, keep overall costs down, and increase the penetration of distributed renewables on the electric grid. These services have potential to provide water utilities additional value streams, using existing equipment with modest or negligible upgrade cost.

  3. Positive Youth Development through Physical Activity: Opportunities for Physical Educators

    ERIC Educational Resources Information Center

    Hemphill, Michael A.

    2014-01-01

    As physical educators continue to advocate for school-based PE, they should also consider ways to extend their work into community settings in an effort to ensure that all kids have an opportunity to develop physical literacy. This article describes how positive youth development programs can provide an opportunity for physical educators to engage…

  4. The role of informal networks in providing effective work opportunities for people with an intellectual disability.

    PubMed

    Donelly, M; Hillman, A; Stancliffe, R J; Knox, M; Whitaker, L; Parmenter, T R

    2010-01-01

    Being in paid employment is socially valued, and is linked to health, financial security and time use. Issues arising from a lack of occupational choice and control, and from diminished role partnerships are particularly problematic in the lives of people with an intellectual disability. Informal support networks are shown to influence work opportunities for people without disabilities, but their impact on the work experiences of people with disability has not been thoroughly explored. The experience of 'work' and preparation for work was explored with a group of four people with an intellectual disability (the participants) and the key members of their informal support networks (network members) in New South Wales, Australia. Network members and participants were interviewed and participant observations of work and other activities were undertaken. Data analysis included open, conceptual and thematic coding. Data analysis software assisted in managing the large datasets across multiple team members. The insight and actions of network members created and sustained the employment and support opportunities that effectively matched the needs and interests of the participants. Recommendations for future research are outlined.

  5. 16 CFR 1101.26 - Circumstances when the Commission does not provide notice and opportunity to comment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Circumstances when the Commission does not provide notice and opportunity to comment. 1101.26 Section 1101.26 Commercial Practices CONSUMER PRODUCT... Section 6(b)(1) § 1101.26 Circumstances when the Commission does not provide notice and opportunity...

  6. Maine 4-H Afterschool Academy--A Professional Development Opportunity for Out-of-School-Time Providers

    ERIC Educational Resources Information Center

    Lobley, Jennifer; Ouellette, Kristy L.

    2013-01-01

    The Maine 4-H Afterschool Academy trained 369 after-school and out of school time providers in 2011. This easy-to-adapt professional development opportunity used blended learning, a combination of in-person and Web-based opportunities. Providers successfully learned concepts and practical knowledge regarding 4-H, specifically 4-H Science. In…

  7. Fragmentation of maternal, child and HIV services: A missed opportunity to provide comprehensive care

    PubMed Central

    Phakathi, Sifiso P.; Grant, Merridy; Mntambo, Ntokozo; Wilford, Aurene

    2016-01-01

    Background In South Africa, coverage of services for mothers and babies in the first year of life is suboptimal despite high immunisation coverage over the same time period. Integration of services could improve accessibility of services, uptake of interventions and retention in care. Aim This study describes provision of services for mothers and babies aged under 1 year. Setting Primary healthcare clinics in one rural district in KwaZulu-Natal, South Africa. Methods All healthcare workers on duty and mothers exiting the clinic after attending well-child services were interviewed. Clinics were mapped to show the route through the clinic taken by mother–baby pairs receiving well-child services, where these services were provided and by whom. Results Twelve clinics were visited; 116 health workers and 211 mothers were interviewed. Most clinics did not provide comprehensive services for mothers and children. Challenges of structural layout and deployment of equipment led to fragmented services provided by several different health workers in different rooms. Well-child services were frequently provided in public areas of the clinic or with other mothers present. In some clinics mothers and babies did not routinely see a professional nurse. In all clinics HIV-positive mothers followed a different route. Enrolled nurses led the provision of well-child services but did not have skills and training to provide comprehensive care. Conclusions Fragmentation of clinic services created barriers in accessing a comprehensive package of care resulting in missed opportunities to provide services. Greater integration of services alongside immunisation services is needed. PMID:28155320

  8. 43 CFR 3281.8 - Must a unit operator provide working interests within the designated unit area the opportunity to...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... interests within the designated unit area the opportunity to join the unit? 3281.8 Section 3281.8 Public... designated unit area the opportunity to join the unit? After BLM designates a unit area, the unit operator... operating rights) in the designated unit area to join the unit. The unit operator must provide the...

  9. 43 CFR 3281.8 - Must a unit operator provide working interests within the designated unit area the opportunity to...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... interests within the designated unit area the opportunity to join the unit? 3281.8 Section 3281.8 Public... designated unit area the opportunity to join the unit? After BLM designates a unit area, the unit operator... operating rights) in the designated unit area to join the unit. The unit operator must provide the...

  10. 43 CFR 3281.8 - Must a unit operator provide working interests within the designated unit area the opportunity to...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... interests within the designated unit area the opportunity to join the unit? 3281.8 Section 3281.8 Public... designated unit area the opportunity to join the unit? After BLM designates a unit area, the unit operator... operating rights) in the designated unit area to join the unit. The unit operator must provide the...

  11. 43 CFR 3281.8 - Must a unit operator provide working interests within the designated unit area the opportunity to...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... interests within the designated unit area the opportunity to join the unit? 3281.8 Section 3281.8 Public... designated unit area the opportunity to join the unit? After BLM designates a unit area, the unit operator... operating rights) in the designated unit area to join the unit. The unit operator must provide the...

  12. ELaNa - Educational Launch of Nanosatellite Providing Routine RideShare Opportunities

    NASA Technical Reports Server (NTRS)

    Skrobot, Garrett Lee; Coelho, Roland

    2012-01-01

    Since the creation of the NASA CubeSat Launch Initiative (NCSLI), the need for CubeSat rideshares has dramatically increased. After only three releases of the initiative, a total of 66 CubeSats now await launch opportunities. So, how is this challenge being resolved? NASA's Launch Services Program (LSP) has studied how to integrate PPODs on Athena, Atlas V, and Delta IV launch vehicles and has been instrumental in developing several carrier systems to support CubeSats as rideshares on NASA missions. In support of the first two ELaNa missions the Poly-Picosatellite Orbital Deployer (P-POD) was adapted for use on a Taurus XL (ELaNa I) and a Delta n (ELaNa III). Four P-PODs, which contained a total eight CubeSats, were used on these first ELaNa missions. Next up is ELaNa VI, which will launch on an Atlas V in August 2012. The four ELaNa VI CubeSats, in three P-PODs, are awaiting launch, having been integrated in the NPSCuLite. To increase rideshare capabilities, the Launch Services Program (LSP) is working to integrate P-PODs on Falcon 9 missions. The proposed Falcon 9 manifest will provide greater opportunities for the CubeSat community. For years, the standard CubeSat size was 1 U to 3U. As the desire to include more science in each cube grows, so does the standard CubeSat size. No longer is a 1 U, 1.5U, 2U or 3U CubeSat the only option available; the new CubeSat standard will include 6U and possibly even 12U. With each increase in CubeSat size, the CubeSat community is pushing the capability of the current P-POD design. Not only is the carrier system affected, but integration to the Launch Vehicle is also a concern. The development of a system to accommodate not only the 3U P-POD but also carriers for larger CubeSats is ongoing. LSP considers payloads in the lkg to 180 kg range rideshare or small/secondary payloads. As new and emerging small payloads are developed, rideshare opportunities and carrier systems need to be identified and secured. The development of a

  13. Opportunity-to-Learn Context-Based Tasks Provided by Mathematics Textbooks

    ERIC Educational Resources Information Center

    Wijaya, Ariyadi; van den Heuvel-Panhuizen, Marja; Doorman, Michiel

    2015-01-01

    Based on the findings of an error analysis revealing that Indonesian ninth- and tenth-graders had difficulties in solving context-based tasks, we investigated the opportunity-to-learn offered by Indonesian textbooks for solving context-based mathematics tasks and the relation of this opportunity-to-learn to students' difficulties in solving these…

  14. Factors Shaping Students' Opportunities to Engage in Argumentative Activity

    ERIC Educational Resources Information Center

    Ayalon, Michal; Even, Ruhama

    2016-01-01

    This study examines how students' opportunities to engage in argumentative activity are shaped by the teacher, the class, and the mathematical topic. It compares the argumentative activity between two classes taught by the same teacher using the same textbook and across two beginning algebra topics--investigating algebraic expressions and…

  15. Physical Activity Opportunity in United States Public Elementary Schools

    ERIC Educational Resources Information Center

    Beaulieu, Lisa; Butterfield, Stephen A.; Pratt, Phillip

    2009-01-01

    Recent evidence indicates that many elementary schools have curtailed recess and Physical Education (Morrow, Jackson & Payne 1999). These finding are at a variance with the goal of Healthy People 2010 to increase physical activity. The purpose of this study was to examine physical activity opportunities (PAO) in U. S. public elementary schools.…

  16. Providing Rich Art Activities for Young Children

    ERIC Educational Resources Information Center

    Mulcahey, Christine

    2009-01-01

    Using works of art with young children is a perfect way to bridge the gap between art activities that are too open or too closed. Teachers of young children sometimes try to find a middle ground by allowing free painting time at an easel in addition to recipe-oriented activities such as putting together precut shapes to create a spider or an apple…

  17. Data Integration: Airborne Data Collections Provide Opportunity for Creative Data Management at ASF

    NASA Astrophysics Data System (ADS)

    Sanches, R. R.; Wolf, V. G.

    2011-12-01

    The Alaska Satellite Facility (ASF) archives and distributes processed airborne data collections, including the Airborne Synthetic Aperture Radar (AIRSAR), Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR), the Alaska High Altitude Photography (AHAP) Collection, the USGS Glacier Collection, and various other photo collections over Alaska. Each dataset presents different management challenges that are being solved using a variety of technological methods. The mechanism for collecting Airborne Synthetic Aperture Radar (SAR) data differs greatly from the methods used to collect satellite-borne SAR data. As a result, metadata for airborne SAR are more complex and are have larger file size than other SAR datasets at ASF. Variations in data format require the need to manipulate the data products as they are ingested at ASF, creating zipped files to reduce the overall volume of individual products, to develop new data products, and tools to promote inter-operability. A goal of the facility is to offer all of the collections through web based interfaces, provide the opportunity for faster download speed, to download the data at several different resolutions, provide bulk download options, and allow for easy data discovery over the customer's selected area of interest. The UAVSAR and AirSAR data collections are digital and fully available online through the ASF data pool. The data are downloaded through a new web interface, designed to facilitate the discovery of online data resources. The aerial photo collections are dominantly hard copies of images, or in film format. Creating logical, systematic, minimum metadata standards for airborne data is a critical step for easy data discovery.

  18. Healthcare providers balancing norms and practice: challenges and opportunities in providing contraceptive counselling to young people in Uganda – a qualitative study

    PubMed Central

    Paul, Mandira; Näsström, Sara B.; Klingberg-Allvin, Marie; Kiggundu, Charles; Larsson, Elin C.

    2016-01-01

    Background Pregnancies among young women force girls to compromise education, resulting in low educational attainment with subsequent poverty and vulnerability. A pronounced focus is needed on contraceptive use, pregnancy, and unsafe abortion among young women. Objective This study aims to explore healthcare providers’ (HCPs) perceptions and practices regarding contraceptive counselling to young people. Design We conducted 27 in-depth interviews with doctors and midwives working in seven health facilities in central Uganda. Interviews were open-ended and allowed the participant to speak freely on certain topics. We used a topic guide to cover areas topics of interest focusing on post-abortion care (PAC) but also covering contraceptive counselling. Transcripts were transcribed verbatim and data were analysed using thematic analysis. Results The main theme, HCPs' ambivalence to providing contraceptive counselling to sexually active young people is based on two sub-themes describing the challenges of contraceptive counselling: A) HCPs echo the societal norms regarding sexual practice among young people, while at the same time our findings B) highlights the opportunities resulting from providers pragmatic approach to contraceptive counselling to young women. Providers expressed a self-identified lack of skill, limited resources, and inadequate support from the health system to successfully provide appropriate services to young people. They felt frustrated with the consultations, especially when meeting young women seeking PAC. Conclusions Despite existing policies for young people's sexual and reproductive health in Uganda, HCPs are not sufficiently equipped to provide adequate contraceptive counselling to young people. Instead, HCPs are left in between the negative influence of social norms and their pragmatic approach to address the needs of young people, especially those seeking PAC. We argue that a clear policy supported by a clear strategy with practical

  19. Licenced to transplant: UK overkill on EU Organ Directive provides golden opportunity for research.

    PubMed

    Cronin, Antonia J; Douglas, James; Sacks, Steven

    2012-10-01

    Progress in transplantation outcomes depends on continuing research into both donor and recipient factors that may enhance graft and patient survival. A system of licencing for transplantation research, introduced by the Human Tissue Act 2004, which separates it from the transplantation process (then exempt from licencing), has damaged this vital activity by a combination of inflexible interpretation of the 2004 Act and fear of criminal liability on the part of researchers. Now, following the European Union (EU) Directive (2010) on standards of quality and safety of human organs intended for transplantation, new UK Regulations have been drafted, which are intended to implement it. These Regulations impose a compulsory licencing system, similar to that for research, on the whole transplantation process. This goes beyond what is required by the Directive and may even have an inhibitory effect similar to that already seen in research. Initial draft Regulations went further, imposing criminal sanctions for breaches. However, following a public consultation process, the Department of Health (DH) has recently stated that, as a result of the overwhelming view of respondents that the proposed licencing system was unnecessary, all sanctions under the final Regulations are now decriminalised, with the sole exception of operating without a licence. While this does not eliminate the negative effect of licencing, it does suggest an awareness of the DH that excessive regulation unnecessarily harms the transplantation process. An opportunity thus arises for the Human Tissue Authority (the regulatory body for both the new licences and research licences under the 2004 Act) to end the current illogical and harmful separation of transplantation and transplantation research by ensuring that all centres licenced for organ donation, retrieval and transplantation are also fully licenced for related research.

  20. Multidimensional physical activity: An opportunity not a problem

    PubMed Central

    Thompson, Dylan; Peacock, Oliver; Western, Max; Batterham, Alan M.

    2015-01-01

    Our research shows that no single metric will adequately reflect an individual’s physical activity because multiple biologically-important dimensions are independent and unrelated. We propose that there is an opportunity to exploit this multidimensional characteristic of physical activity in order to improve personalised feedback and offer physical activity options and choices that are tailored to an individual’s needs and preferences. PMID:25607280

  1. Practicing provider-initiated HIV testing in high prevalence settings: consent concerns and missed preventive opportunities

    PubMed Central

    2011-01-01

    measures. Informants expressed frustration related to their experienced inability to 'opt-out' or decline from the provider-initiated HIV testing services. Conclusion Counselling emerged as a highly valued process during HIV testing. However, counselling efforts were limited in the implementation of the provider-initiated opt-out HIV testing model. The approach was moreover not perceived as voluntary. This raises serious ethical concerns and implies missed preventive opportunities inherent in the counselling concept. Moreover, implementation of the new testing approach seem to add a burden to pregnant women as disproportionate numbers of women get to know their HIV status, reveal their HIV status to their spouse and recruit their spouses to go for a test. We argue that there is an urgent need to reconsider the manner in which the provider initiated HIV testing model is implemented in order to protect the client's autonomy and to maximise access to HIV prevention. PMID:21507273

  2. International Observe the Moon Night: Providing Opportunities for the Public to Engage in Lunar Observation

    NASA Astrophysics Data System (ADS)

    Hsu, B. C.; Bleacher, L.; Day, B. H.; Daou, D.; Jones, A. P.; Mitchell, B.; Shaner, A. J.; Shipp, S. S.

    2010-12-01

    International Observe the Moon Night (InOMN) is designed to engage lunar science and education communities, our partner networks, amateur astronomers, space enthusiasts, and the general public in annual lunar observation campaigns that share the excitement of lunar science and exploration. InOMN enables the public to maintain its curiosity about the Moon and gain a better understanding of the Moon's formation, its evolution, and its place in the sky. For 2010, members of the public were encouraged to host their own InOMN events. InOMN hosts such as astronomy clubs, museums, schools, or other groups could find helpful resources and share information about InOMN events they organized on the InOMN website (http://observethemoonnight.org). Images, feedback, and lessons learned from the 2010 InOMN event will be shared in order to encourage increased planning and hosting of InOMN events in 2011. From various interpretations of the lunar “face,” early pictograms of the Moon’s phases, or to the use of the lunar cycle for festivals or harvests, the Moon has an undeniable influence on human civilization. We have chosen the 2011 InOMN theme to provide an opportunity for individuals to share their personal or cultural connections to the Moon. For 2011, the InOMN website will include a ‘lunar bulletin board’ where InOMN participants can post pictures and share stories of what the Moon means to them. The 2011 InOMN contest will encourage people to submit their works of art, poems, short stories, or music about the Moon all centered around the theme “What does the Moon mean to you?” As with the winners of previous contests, winning entries will be incorporated into the following year’s InOMN advertisements and events.

  3. Health Care Provider Physical Activity Prescription Intervention

    ERIC Educational Resources Information Center

    Josyula, Lakshmi; Lyle, Roseann

    2013-01-01

    Purpose: To examine the feasibility and impact of a health care provider’s (HCP) physical activity (PA) prescription on the PA of patients on preventive care visits. Methods: Consenting adult patients completed health and PA questionnaires and were sequentially assigned to intervention groups. HCPs prescribed PA using a written prescription only…

  4. Providing High School Students with Opportunities to Reason like Evolutionary Biologists

    ERIC Educational Resources Information Center

    Passmore, Cynthia; Stewart, Jim; Zoellner, Brian

    2005-01-01

    When students are given opportunities to use their knowledge to explain interesting and appropriate evolutionary phenomena, their potential for understanding evolutionary concepts increases. In this article, the authors describe a nine-week high school evolutionary biology course designed to engage students in using Darwin's natural selection…

  5. Providing Opportunities for Deeper Learning: Findings from the Study of Deeper Learning

    ERIC Educational Resources Information Center

    Bitter, Catherine; O'Day, Jennifer

    2014-01-01

    The "Study of Deeper Learning: Opportunities and Outcomes," funded by the William and Flora Hewlett Foundation, is a "proof-of-concept" study to determine whether students attending high schools with a mature and at least moderately well-implemented approach to promoting "deeper learning" experience greater deeper…

  6. Providing Optimal Opportunities: Structuring Practicum Experiences in Early Intervention and Early Childhood Special Education Preservice Programs

    ERIC Educational Resources Information Center

    Macy, Marisa; Squires, Jane K.; Barton, Erin E.

    2009-01-01

    An approach to designing field-based practicum opportunities for preservice students is described. First, the importance of quality field experiences is presented, together with a conceptual framework. Second, foundational and philosophical perspectives in early childhood and early intervention (EI) and early childhood special education (ECSE)…

  7. Municipal Government Efforts to Provide Career Employment Opportunities for the Disadvantaged.

    ERIC Educational Resources Information Center

    Decker, Floyd A.; And Others

    The study, conducted in Dayton, Detroit, El Paso, New York City, San Francisco, and Washington, D.C., investigated efforts to create municipal career employment and training opportunities for those who cannot meet traditional entrance requirements. It also examined the impact of programs on municipal services, and ways in which such programs can…

  8. The Flipped Classroom: An Opportunity to Engage Millennial Students through Active Learning Strategies

    ERIC Educational Resources Information Center

    Roehl, Amy; Reddy, Shweta Linga; Shannon, Gayla Jett

    2013-01-01

    "Flipping" the classroom employs easy-to-use, readily accessible technology in order to free class time from lecture. This allows for an expanded range of learning activities during class time. Using class time for active learning versus lecture provides opportunities for greater teacher-to-student mentoring, peer-to-peer collaboration…

  9. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... opportunity to comment on proposed Federal financial assistance and direct Federal development? 660.8 Section 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  10. 2013 HIPAA Changes Provide Opportunities and Challenges for Researchers: Perspectives from a Cancer Center.

    PubMed

    Freedman, Ralph S; Cantor, Scott B; Merriman, Kelly W; Edgerton, Mary E

    2016-02-01

    In 2013, the U.S. Department of Health and Human Services modified the Health Insurance Portability and Accountability Act Privacy Rule to "strengthen privacy and security protections" while "improving workability and effectiveness to increase flexibility for and decrease burden on regulated entities." In this article, we attempt to translate these generalized goals into the real-world implications of these changes. Under the new rules, researchers can obtain participants' permission to use their protected health information for more research activities with a single, upfront authorization (thereby reducing paperwork for participants, researchers, and institutional review boards) while providing potential participants with more information upon which to base their decisions about participation. The combined authorizations can be used in clinical trials and their optional substudies and in stand-alone biospecimen-banking research that includes authorization to permit future research use. We also suggest best practices for taking advantage of the flexibility offered by the new rules while maintaining strong privacy protections for human subjects.

  11. 16 CFR 1101.26 - Circumstances when the Commission does not provide notice and opportunity to comment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Circumstances when the Commission does not provide notice and opportunity to comment. 1101.26 Section 1101.26 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT...

  12. Mars Public Mapping Project: Public Participation in Science Research; Providing Opportunities for Kids of All Ages

    NASA Astrophysics Data System (ADS)

    Rogers, L. D.; Valderrama Graff, P.; Bandfield, J. L.; Christensen, P. R.; Klug, S. L.; Deva, B.; Capages, C.

    2007-12-01

    The Mars Public Mapping Project is a web-based education and public outreach tool developed by the Mars Space Flight Facility at Arizona State University. This tool allows the general public to identify and map geologic features on Mars, utilizing Thermal Emission Imaging System (THEMIS) visible images, allowing public participation in authentic scientific research. In addition, participants are able to rate each image (based on a 1 to 5 star scale) to help build a catalog of some of the more appealing and interesting martian surface features. Once participants have identified observable features in an image, they are able to view a map of the global distribution of the many geologic features they just identified. This automatic feedback, through a global distribution map, allows participants to see how their answers compare to the answers of other participants. Participants check boxes "yes, no, or not sure" for each feature that is listed on the Mars Public Mapping Project web page, including surface geologic features such as gullies, sand dunes, dust devil tracks, wind streaks, lava flows, several types of craters, and layers. Each type of feature has a quick and easily accessible description and example image. When a participant moves their mouse over each example thumbnail image, a window pops up with a picture and a description of the feature. This provides a form of "on the job training" for the participants that can vary with their background level. For users who are more comfortable with Mars geology, there is also an advanced feature identification section accessible by a drop down menu. This includes additional features that may be identified, such as streamlined islands, valley networks, chaotic terrain, yardangs, and dark slope streaks. The Mars Public Mapping Project achieves several goals: 1) It engages the public in a manner that encourages active participation in scientific research and learning about geologic features and processes. 2) It helps to

  13. Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT.

    PubMed

    Topiol, Sid; Bang-Andersen, Benny; Sanchez, Connie; Bøgesø, Klaus P

    2016-10-15

    The recently reported X-ray structures of the human serotonin (5-HT) transporter SERT with bound inhibitors open new opportunities for drug discovery at SERT, selectivity design with respect to other neurotransmitter sodium transporters, and enhanced understanding of the molecular events involved in SERT action. Through computational and structural analyses, we explore the binding and migration of 5-HT at SERT. Consistent with earlier studies of leucine migration at the bacterial homolog of SERT, LeuT, we find multiple potential 'stopover' sites for 5-HT binding at SERT including the two (transmembrane S1 and extracellular vestibule S2) seen in the binding of the SSRI (S)-citalopram (S-Cit) to SERT, as well as other sites. Docking studies reveal the possibility of both hetero- (S-Cit+5-HT) and homo-dimeric (5-HT+5-HT) co-binding at both these sites which may explain earlier published allosteric activity observations and provide novel design strategies. Comparisons with substrate bound X-ray structures of the dopamine transporter reveal a number of potential sources of selectivity, some of which may be 'artificial' including target based, species related, experimental design related, and ligand dependent examples including substrate versus inhibitor related features.

  14. Providing a setup and opportunities for better training of postdoctoral research fellows in an academic environment.

    PubMed

    Ghayur, Muhammad N

    2008-01-01

    Thousands of young researchers come from different parts of the world every year to take up postdoctoral (postdoc) research fellowship positions in the developed countries. In the US alone, there were 48,601 postdocs in the year 2005 working in different labs in the fields of science, health and engineering. Many pursue this option for lack of other alternatives. Expectedly, these individuals face a lot of difficulties in making this transition from being a student to becoming an employee of an institution. Many institutions are prepared to make this transition and period of stay easy for their fellows while others are not equipped at all. The presence of a postdoc office (established by an institution) or an association (formed by the fellows) can be of immense help to postdocs. Additionally, the availability of institutional professional development and leadership programs can also help to nurture and polish postdoc fellows into future faculty members and valuable members of the community at large. To name a few, these professional development programs can focus on communication and presentation skills, medical education, teaching and learning, bioethics and mentorship. There is an urgent need to address some or all of these issues so that better training environment and opportunities are available to this group of postdoc fellows.

  15. Understanding Adults as Learners--Guidelines for Providing Effective Training Opportunities.

    ERIC Educational Resources Information Center

    Alexander, Nancy P.

    1999-01-01

    This article presents principles for effective adult learning applicable in child care settings. These principles include the need for motivation to learn, the view that learning is an active process, the benefits from guidance, the importance of appropriate materials and activities for sequential learning, the need for reinforcement and varied…

  16. Providing Undergraduate Research Opportunities Through the World Rivers Observatory Collaborative Network

    NASA Astrophysics Data System (ADS)

    Gillies, S. L.; Marsh, S. J.; Janmaat, A.; Peucker-Ehrenbrink, B.; Voss, B.; Holmes, R. M.

    2013-12-01

    Successful research collaboration exists between the University of the Fraser Valley (UFV), a primarily undergraduate-serving university located on the Fraser River in British Columbia, and the World Rivers Observatory that is coordinated through the Woods Hole Oceanographic Institution (WHOI) and the Woods Hole Research Center (WHRC). The World Rivers Observatory coordinates time-series sampling of 15 large rivers, with particular focus on the large Arctic rivers, the Ganges-Brahmaputra, Congo, Fraser, Yangtze (Changjiang), Amazon, and Mackenzie River systems. The success of this international observatory critically depends on the participation of local collaborators, such as UFV, that are necessary in order to collect temporally resolved data from these rivers. Several faculty members and undergraduate students from the Biology and Geography Departments of UFV received on-site training from the lead-PIs of the Global Rivers Observatory. To share information and ensure good quality control of sampling methods, WHOI and WHRC hosted two international workshops at Woods Hole for collaborators. For the past four years, faculty and students from UFV have been collecting a variety of bi-monthly water samples from the Fraser River for the World Rivers Observatory. UFV undergraduate students who become involved learn proper sampling techniques and are given the opportunity to design and conduct their own research. Students have collected, analyzed and presented data from this project at regional, national, and international scientific meetings. UFV undergraduate students have also been hosted by WHOI and WHRC as guest students to work on independent research projects. While at WHOI and WHRC, students are able to conduct research using state-of-the-art specialized research facilities not available at UFV.

  17. Making non-discrimination and equal opportunity a reality in Kenya's health provider education system: results of a gender analysis.

    PubMed

    Newman, Constance; Kimeu, Anastasiah; Shamblin, Leigh; Penders, Christopher; McQuide, Pamela A; Bwonya, Judith

    2011-01-01

    IntraHealth International's USAID-funded Capacity Kenya project conducted a performance needs assessment of the Kenya health provider education system in 2010. Various stakeholders shared their understandings of the role played by gender and identified opportunities to improve gender equality in health provider education. Findings suggest that occupational segregation, sexual harassment and discrimination based on pregnancy and family responsibilities present problems, especially for female students and faculty. To grow and sustain its workforce over the long term, Kenyan human resource leaders and managers must act to eliminate gender-based obstacles by implementing existing non-discrimination and equal opportunity policies and laws to increase the entry, retention and productivity of students and faculty. Families and communities must support girls' schooling and defer early marriage. All this will result in a fuller pool of students, faculty and matriculated health workers and, ultimately, a more robust health workforce to meet Kenya's health challenges.

  18. Using Poetry as Data Representation to Explore Music Opportunities Parents Provide for Their Children at Home

    ERIC Educational Resources Information Center

    de Vries, Peter

    2007-01-01

    This article presents poetry as data and reports on how this poetry was used to present themes that emerged in interviews with three parents of children under the age of 5 in a study of the music activities they chose to initiate in the home following a musical parenting workshop conducted by the researcher. Poetry written by the researcher was…

  19. Providing Authentic Leadership Opportunities through Collaboratively Developed Internships: A University-School District Partnership Initiative

    ERIC Educational Resources Information Center

    Havard, Timothy S.; Morgan, Joyce; Patrick, Lynne

    2010-01-01

    Programs designed to develop future educational leaders must include practical learning experiences that connect the theoretical content of university coursework with the realities of the K-12 workplace. Internships, which offer a common method of providing these experiences, have been generally lacking in the degree to which aspiring leaders…

  20. Science in Sync: Integrating Science with Literacy Provides Rewarding Learning Opportunities in Both Subjects

    ERIC Educational Resources Information Center

    Wallace, Carolyn S.; Coffey, Debra

    2016-01-01

    The "Next Generation Science Standards'" ("NGSS") eight scientific and engineering practices invite teachers to develop key investigative skills while addressing important disciplinary science ideas (NGSS Lead States 2013). The "NGSS" can also provide direct links to "Common Core English Language Arts…

  1. Signal transduction pathways provide opportunities to enhance HDL and apoAI-dependent reverse cholesterol transport.

    PubMed

    Mulay, Vishwaroop; Wood, Peta; Rentero, Carles; Enrich, Carlos; Grewal, Thomas

    2012-02-01

    Binding of High Density Lipoprotein (HDL) and its major apolipoprotein A-I (apoA-I) to cell surface receptors is believed to initiate a plethora of signaling cascades that promote atheroprotective cell behavior, including the removal of excess cholesterol from lipid-loaded macrophages. More specifically, HDL and apoA-I binding to scavenger receptor BI (SR-BI) and ATP-binding cassette (ABC) transporter A1 has been shown to activate protein kinase A and C (PKA, PKC), Rac/Rho GTPases, Janus Kinase 2 (JAK2), calmodulin as well as mitogen-activated protein kinases (MAPK). Some of these signaling events upregulate mobilization of cholesterol from cellular pools, while others promote efflux pathways through increased expression, stability, and cell surface localization of SR-BI and ABCA1. This review aims to summarize the current knowledge of HDL- and apoA-I -induced signal transduction pathways that are linked to cholesterol efflux and discusses the underlying mechanisms that could couple ligand binding to SR-BI and ABCA1 with signaling and cholesterol export. Additional focus is given on the potential of pharmacological intervention to modulate the activity of signaling cascades for the inhibition or regression of cholesterol accumulation in atherosclerotic lesions.

  2. Schedule Best Practices Provide Opportunity to Enhance Missile Defense Agency Accountability and Program Execution

    DTIC Science & Technology

    2012-07-19

    accountability of MDA programs, in the April 2012 review; instead, we are providing in this report (1) the results of how the MDA program schedules compare...developed for several months at a time instead of for the life of the program. As a result, our findings on the specific program schedules are limited...practices, and some had major deficiencies. These results are significant because a reliable schedule is one key factor that indicates a program is

  3. Provider experiences with RAC appeals point to opportunities for program improvement.

    PubMed

    Jacobs, Robert; Scott, Bonnie; Flood, Elizabeth; Scott, Ellen

    2011-03-01

    Review by an administrative law judge (ALJ) constitutes the third level of appeal for healthcare providers seeking to overturn reverse recovery audit contractor (RAC) findings of overpayment of Medicare claims. An analysis of the results of RAC appeals submitted by 30 New York hospitals during the demonstration project has disclosed two deficiencies in the ALJ review process: inconsistent ALJ decision making and a lack of an appropriate feedback mechanism to correct erroneous overpayment determinations. The Centers for Medicare & Medicaid Services should take advantage of feedback from such studies as an impetus to reevaluate and streamline the RAC appeals process.

  4. Technology transfer opportunities: new development: computerized field manual provides valuable resource for hydrologic investigations

    USGS Publications Warehouse

    Chapel, Paul

    1996-01-01

    The U.S. Geological Survey (USGS) is known throughout the world for conducting quality scientific investigation is hydrologic environments. Proper and consistent field techniques have been an integral part of this good research. Over the past few decades, the USGS has developed and published detailed, standard protocols for conducting studies in most aspects of the hydrologic environment. These protocols have been published in a number of diverse documents. The wealth of information contained in these diverse documents can benefit other scientists in industry, government, and academia that are involved in conducting hydrologic studies. Scientists at the USGS have brought together many of the most important of the field protocols in a user-friendly, graphical-interfaced field manual that will be useful in both the field and in the office. This electronic field manual can assist hydrologists and other scientists in conducting and documenting their field activities in a manner that is recognized standard throughout the hydrologic community.

  5. Wood density provides new opportunities for reconstructing past temperature variability from southeastern Australian trees

    NASA Astrophysics Data System (ADS)

    O'Donnell, Alison J.; Allen, Kathryn J.; Evans, Robert M.; Cook, Edward R.; Trouet, Valerie; Baker, Patrick J.

    2016-06-01

    Tree-ring based climate reconstructions have been critical for understanding past variability and recent trends in climate worldwide, but they are scarce in Australia. This is particularly the case for temperature: only one tree-ring width based temperature reconstruction - based on Huon Pine trees from Mt Read, Tasmania - exists for Australia. Here, we investigate whether additional tree-ring parameters derived from Athrotaxis cupressoides trees growing in the same region have potential to provide robust proxy records of past temperature variability. We measured wood properties, including tree-ring width (TRW), mean density, mean cell wall thickness (CWT), and tracheid radial diameter (TRD) of annual growth rings in Athrotaxis cupressoides, a long-lived, high-elevation conifer in central Tasmania, Australia. Mean density and CWT were strongly and negatively correlated with summer temperatures. In contrast, the summer temperature signal in TRW was weakly positive. The strongest climate signal in any of the tree-ring parameters was maximum temperature in January (mid-summer; JanTmax) and we chose this as the target climate variable for reconstruction. The model that explained most of the variance in JanTmax was based on TRW and mean density as predictors. TRW and mean density provided complementary proxies with mean density showing greater high-frequency (inter-annual to multi-year) variability and TRW showing more low-frequency (decadal to centennial-scale) variability. The final reconstruction model is robust, explaining 55% of the variance in JanTmax, and was used to reconstruct JanTmax for the last five centuries (1530-2010 C.E.). The reconstruction suggests that the most recent 60 years have been warmer than average in the context of the last ca. 500 years. This unusually warm period is likely linked to a coincident increase in the intensity of the subtropical ridge and dominance of the positive phase of the Southern Annular Mode in summer, which weaken the

  6. Intensity of commonly-reported classroom-based physical activity opportunities in public schools.

    PubMed

    Behrens, Timothy K; Holeva, Whitney M; Carpenter, Dick; Tucker, Elizabeth; Luna, Carmen; Donovan, John; Field, Julaine; Kelly, Cheryl

    2017-06-01

    The purpose of this study was to examine the intensity levels of PA opportunities offered in public school classrooms. Schools (N = 101) in school districts (N = 25) reported PA opportunities offered in classrooms using an online data collection tool over a two-year period (2014-2016). Using a randomized sampling technique, 20-30% of teachers in each school were selected each week to report PA in their classroom. These responses resulted in N = 18,210 usable responses. A researcher determined the intensity of PA opportunities using the 2011 Compendium of Physical Activities as a guideline; two additional researchers confirmed the coded categories. A descriptive analysis of PA opportunities was conducted to describe the proportion of opportunities whose intensity levels were light (LPA), moderate (MPA), vigorous (VPA), sedentary (SED), and those of unknown intensity. Chi-square analyses were utilized to examine differences between proportions of intensity levels offered by semester. Kruskal-Wallace tests were utilized to examine differences in proportion of physical activity opportunity intensity offered by grade level. Most PA opportunities were MPA (58.7%), followed by VPA (17.6%) and LPA (11.5%). Few responses were SED (0.5%), and 11.6% were of indeterminate intensity. A greater proportion of more physically intense activities reported during the fall versus spring semesters (p < 0.0001). Differences in the intensity levels of PA offered by grade also differed, with a trend of decreasing intensity as grade level increased (p < 0.0001). This study provides insight into the PA actually occurring in classrooms; a previously underexplored construct of school-based PA.

  7. Self-Organization Activities of College Students: Challenges and Opportunities

    ERIC Educational Resources Information Center

    Shmurygina, Natalia; Bazhenova, Natalia; Bazhenov, Ruslan; Nikolaeva, Natalia; Tcytcarev, Andrey

    2016-01-01

    The article provides the analysis of self-organization activities of college students related to their participation in youth associations activities. The purpose of research is to disclose a degree of students' activities demonstration based on self-organization processes, assessment of existing self-organization practices of the youth,…

  8. Vitamin Variation in Capsicum Spp. Provides Opportunities to Improve Nutritional Value of Human Diets

    PubMed Central

    Lucht, Sarah A.; Mercer, Kristin; Bernau, Vivian; Case, Kyle A.; Le, Nina C.; Frederiksen, Matthew K.; DeKeyser, Haley C.; Wong, Zen-Zi; Hastings, Jennifer C.

    2016-01-01

    Chile peppers, native to the Americas, have spread around the world and have been integrated into the diets of many cultures. Much like their heat content, nutritional content can vary dramatically between different pepper types. In this study, a diverse set of chile pepper types were examined for nutrient content. Some pepper types were found to have high levels of vitamin A, vitamin C, or folate. Correlations between nutrient content, species, cultivation status, or geographic region were limited. Varietal selection or plant breeding offer tools to augment nutrient content in peppers. Integration of nutrient rich pepper types into diets that already include peppers could help combat nutrient deficiencies by providing a significant portion of recommended daily nutrients. PMID:27532495

  9. Global positioning system: a new opportunity in physical activity measurement.

    PubMed

    Maddison, Ralph; Ni Mhurchu, Cliona

    2009-11-04

    Accurate measurement of physical activity is a pre-requisite to monitor population physical activity levels and design effective interventions. Global Positioning System (GPS) technology offers potential to improve the measurement of physical activity. This paper 1) reviews the extant literature on the application of GPS to monitor human movement, with a particular emphasis on free-living physical activity, 2) discusses issues associated with GPS use, and 3) provides recommendations for future research. Overall findings show that GPS is a useful tool to augment our understanding of physical activity by providing the context (location) of the activity and used together with Geographical Information Systems can provide some insight into how people interact with the environment. However, no studies have shown that GPS alone is a reliable and valid measure of physical activity.

  10. Global positioning system: a new opportunity in physical activity measurement

    PubMed Central

    Maddison, Ralph; Ni Mhurchu, Cliona

    2009-01-01

    Accurate measurement of physical activity is a pre-requisite to monitor population physical activity levels and design effective interventions. Global Positioning System (GPS) technology offers potential to improve the measurement of physical activity. This paper 1) reviews the extant literature on the application of GPS to monitor human movement, with a particular emphasis on free-living physical activity, 2) discusses issues associated with GPS use, and 3) provides recommendations for future research. Overall findings show that GPS is a useful tool to augment our understanding of physical activity by providing the context (location) of the activity and used together with Geographical Information Systems can provide some insight into how people interact with the environment. However, no studies have shown that GPS alone is a reliable and valid measure of physical activity. PMID:19887012

  11. Do nanoparticles provide a new opportunity for diagnosis of distal airspace disease?

    PubMed

    Löndahl, Jakob; Jakobsson, Jonas Kf; Broday, David M; Aaltonen, H Laura; Wollmer, Per

    There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 µm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature. Using nanoparticles for studying distal airspace dimensions is shown to have several advantages over other aerosol-based methods. 1) Nanoparticles deposit almost exclusively by diffusion, which allows a simpler breathing maneuver with minor artifacts from particle losses in the oropharyngeal and upper airways. 2) A higher breathing flow rate can be utilized, making it possible to rapidly inhale from residual volume to total lung capacity (TLC), thereby eliminating the need to determine the TLC before measurement. 3) Recent studies indicate better penetration of nanoparticles than micron-sized particles into poorly ventilated and diseased regions of the lungs; thus, a stronger signal from the abnormal parts is expected. 4) Changes in airspace dimensions have a larger impact on the recovery of nanoparticles. Compared to current diagnostic techniques with high specificity for morphometric changes of the lungs, computed tomography and magnetic resonance imaging with hyperpolarized gases, an aerosol-based method is likely to be less time consuming, considerably cheaper, simpler to use, and easier to interpret (providing a single value rather than an image that has to be analyzed). Compared to diagnosis by carbon monoxide (DL,CO), the uptake of nanoparticles in the lung is not affected by blood flow, hemoglobin concentration or alterations of the alveolar

  12. Healthcare Hackathons Provide Educational and Innovation Opportunities: A Case Study and Best Practice Recommendations.

    PubMed

    Silver, Julie K; Binder, David S; Zubcevik, Nevena; Zafonte, Ross D

    2016-07-01

    Physicians and other healthcare professionals are often the end users of medical innovation; however, they are rarely involved in the beginning design stages. This often results in ineffective healthcare solutions with poor adoption rates. At the early design stage, innovation would benefit from input from healthcare professionals. This report describes the first-ever rehabilitation hackathon-an interdisciplinary and competitive team event aimed at accelerating and improving healthcare solutions and providing an educational experience for participants. Hackathons are gaining traction as a way to accelerate innovation by bringing together a diverse group of interdisciplinary professionals from different industries who work collaboratively in teams and learn from each other, focus on a specific problem ("pain point"), develop a solution using design thinking techniques, pitch the solution to participants, gather fast feedback and quickly alter the prototype design ("pivoting"). 102 hackers including 19 (18.6 %) physicians and other professionals participated, and over the course of 2 days worked in teams, pitched ideas and developed design prototypes. Three awards were given for prototypes that may improve function in persons with disabilities. 43 hackers were women (42.2 %) and 59 men (57.8 %); they ranged in age from 16 to 79 years old; and, of the 75 hackers who reported their age, 63 (84 %) were less than 40 years old and 12 (16 %) were 40 years or older. This report contributes to the emerging literature on healthcare hackathons as a means of providing interdisciplinary education and training and supporting innovation.

  13. Do nanoparticles provide a new opportunity for diagnosis of distal airspace disease?

    PubMed Central

    Löndahl, Jakob; Jakobsson, Jonas KF; Broday, David M; Aaltonen, H Laura; Wollmer, Per

    2017-01-01

    There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4–1.5 µm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature. Using nanoparticles for studying distal airspace dimensions is shown to have several advantages over other aerosol-based methods. 1) Nanoparticles deposit almost exclusively by diffusion, which allows a simpler breathing maneuver with minor artifacts from particle losses in the oropharyngeal and upper airways. 2) A higher breathing flow rate can be utilized, making it possible to rapidly inhale from residual volume to total lung capacity (TLC), thereby eliminating the need to determine the TLC before measurement. 3) Recent studies indicate better penetration of nanoparticles than micron-sized particles into poorly ventilated and diseased regions of the lungs; thus, a stronger signal from the abnormal parts is expected. 4) Changes in airspace dimensions have a larger impact on the recovery of nanoparticles. Compared to current diagnostic techniques with high specificity for morphometric changes of the lungs, computed tomography and magnetic resonance imaging with hyperpolarized gases, an aerosol-based method is likely to be less time consuming, considerably cheaper, simpler to use, and easier to interpret (providing a single value rather than an image that has to be analyzed). Compared to diagnosis by carbon monoxide (DL,CO), the uptake of nanoparticles in the lung is not affected by blood flow, hemoglobin concentration or alterations of the

  14. Opportunities and challenges provided by cloud repositories for bioinformatics-enabled drug discovery.

    PubMed

    Dalpé, Gratien; Joly, Yann

    2014-09-01

    Healthcare-related bioinformatics databases are increasingly offering the possibility to maintain, organize, and distribute DNA sequencing data. Different national and international institutions are currently hosting such databases that offer researchers website platforms where they can obtain sequencing data on which they can perform different types of analysis. Until recently, this process remained mostly one-dimensional, with most analysis concentrated on a limited amount of data. However, newer genome sequencing technology is producing a huge amount of data that current computer facilities are unable to handle. An alternative approach has been to start adopting cloud computing services for combining the information embedded in genomic and model system biology data, patient healthcare records, and clinical trials' data. In this new technological paradigm, researchers use virtual space and computing power from existing commercial or not-for-profit cloud service providers to access, store, and analyze data via different application programming interfaces. Cloud services are an alternative to the need of larger data storage; however, they raise different ethical, legal, and social issues. The purpose of this Commentary is to summarize how cloud computing can contribute to bioinformatics-based drug discovery and to highlight some of the outstanding legal, ethical, and social issues that are inherent in the use of cloud services.

  15. Antibodies Against Conserved Antigens Provide Opportunities for Reform in Influenza Vaccine Design

    PubMed Central

    Kaminski, Denise A.; Lee, F. Eun-Hyung

    2011-01-01

    High-performance neutralizing antibody against influenza virus typically recognizes the globular head region of its hemagglutinin (HA) envelope glycoprotein. To-date, approved human vaccination strategies have been designed to induce such antibodies as a sole means of preventing the consequences of this infection. However, frequent amino-acid changes in the HA globular head allow for efficient immune evasion. Consequently, vaccines inducing such neutralizing antibodies need to be annually re-designed and re-administered at a great expense. These vaccines furthermore provide little-to-no immunity against antigenic-shift strains, which arise from complete replacement of HA or of neuraminidase genes, and pose pandemic risks. To address these issues, laboratory research has focused on inducing immunity effective against all strains, regardless of changes in the HA globular head. Despite prior dogma that such cross-protection needs to be induced by cellular immunity alone, several advances in recent years demonstrate that antibodies of other specificities are capable of cross-strain protection in mice. This review discusses the reactivity, induction, efficacy, and mechanisms of antibodies that react with poorly accessible epitopes in the HA stalk, with the matrix 2 membrane ion channel, and even with the internal nucleoprotein. These advances warrant further investigation of the inducibility and efficacy of such revolutionary antibody strategies in humans. PMID:22566865

  16. Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention

    PubMed Central

    Martinson, Holly A.; Lyons, Traci R.; Giles, Erin D.; Borges, Virginia F.; Schedin, Pepper

    2014-01-01

    The magnitude of the breast cancer problem implores researchers to aggressively investigate prevention strategies. However, several barriers currently reduce the feasibility of breast cancer prevention. These barriers include the inability to accurately predict future breast cancer diagnosis at the individual level, the need for improved understanding of when to implement interventions, uncertainty with respect to optimal duration of treatment, and negative side effects associated with currently approved chemoprevention therapies. None-the-less, the unique biology of the mammary gland, with its postnatal development and conditional terminal differentiation, may permit the resolution of many of these barriers. Specifically, lifecycle-specific windows of breast cancer risk have been identified that may be amenable to risk-reducing strategies. Here, we argue for prevention research focused on two of these lifecycle windows of risk: postpartum mammary gland involution and peri-menopause. We provide evidence that these windows are highly amenable to targeted, limited duration treatments. Such approaches could result in the prevention of postpartum and postmenopausal breast cancers, correspondingly. PMID:23664839

  17. Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention.

    PubMed

    Martinson, Holly A; Lyons, Traci R; Giles, Erin D; Borges, Virginia F; Schedin, Pepper

    2013-07-01

    The magnitude of the breast cancer problem implores researchers to aggressively investigate prevention strategies. However, several barriers currently reduce the feasibility of breast cancer prevention. These barriers include the inability to accurately predict future breast cancer diagnosis at the individual level, the need for improved understanding of when to implement interventions, uncertainty with respect to optimal duration of treatment, and negative side effects associated with currently approved chemoprevention therapies. None-the-less, the unique biology of the mammary gland, with its postnatal development and conditional terminal differentiation, may permit the resolution of many of these barriers. Specifically, lifecycle-specific windows of breast cancer risk have been identified that may be amenable to risk-reducing strategies. Here, we argue for prevention research focused on two of these lifecycle windows of risk: postpartum mammary gland involution and peri-menopause. We provide evidence that these windows are highly amenable to targeted, limited duration treatments. Such approaches could result in the prevention of postpartum and postmenopausal breast cancers, correspondingly.

  18. Post-copulatory opportunities for sperm competition and cryptic female choice provide no offspring fitness benefits in externally fertilizing salmon.

    PubMed

    Lumley, Alyson J; Diamond, Sian E; Einum, Sigurd; Yeates, Sarah E; Peruffo, Danielle; Emerson, Brent C; Gage, Matthew J G

    2016-03-01

    There is increasing evidence that females can somehow improve their offspring fitness by mating with multiple males, but we understand little about the exact stage(s) at which such benefits are gained. Here, we measure whether offspring fitness is influenced by mechanisms operating solely between sperm and egg. Using externally fertilizing and polyandrous Atlantic salmon (Salmo salar), we employed split-clutch and split-ejaculate in vitro fertilization experiments to generate offspring using designs that either denied or applied opportunities for sperm competition and cryptic female choice. Following fertilizations, we measured 140 days of offspring fitness after hatch, through growth and survival in hatchery and near-natural conditions. Despite an average composite mortality of 61%, offspring fitness at every life stage was near-identical between groups fertilized under the absence versus presence of opportunities for sperm competition and cryptic female choice. Of the 21 551 and 21 771 eggs from 24 females fertilized under monandrous versus polyandrous conditions, 68% versus 67.8% survived to the 100-day juvenile stage; sub-samples showed similar hatching success (73.1% versus 74.3%), had similar survival over 40 days in near-natural streams (57.3% versus 56.2%) and grew at similar rates throughout. We therefore found no evidence that gamete-specific interactions allow offspring fitness benefits when polyandrous fertilization conditions provide opportunities for sperm competition and cryptic female choice.

  19. Post-copulatory opportunities for sperm competition and cryptic female choice provide no offspring fitness benefits in externally fertilizing salmon

    PubMed Central

    Lumley, Alyson J.; Diamond, Sian E.; Einum, Sigurd; Yeates, Sarah E.; Peruffo, Danielle; Emerson, Brent C.; Gage, Matthew J. G.

    2016-01-01

    There is increasing evidence that females can somehow improve their offspring fitness by mating with multiple males, but we understand little about the exact stage(s) at which such benefits are gained. Here, we measure whether offspring fitness is influenced by mechanisms operating solely between sperm and egg. Using externally fertilizing and polyandrous Atlantic salmon (Salmo salar), we employed split-clutch and split-ejaculate in vitro fertilization experiments to generate offspring using designs that either denied or applied opportunities for sperm competition and cryptic female choice. Following fertilizations, we measured 140 days of offspring fitness after hatch, through growth and survival in hatchery and near-natural conditions. Despite an average composite mortality of 61%, offspring fitness at every life stage was near-identical between groups fertilized under the absence versus presence of opportunities for sperm competition and cryptic female choice. Of the 21 551 and 21 771 eggs from 24 females fertilized under monandrous versus polyandrous conditions, 68% versus 67.8% survived to the 100-day juvenile stage; sub-samples showed similar hatching success (73.1% versus 74.3%), had similar survival over 40 days in near-natural streams (57.3% versus 56.2%) and grew at similar rates throughout. We therefore found no evidence that gamete-specific interactions allow offspring fitness benefits when polyandrous fertilization conditions provide opportunities for sperm competition and cryptic female choice. PMID:27069665

  20. 77 FR 69604 - Agency Information Collection Activities; Comment Request; Educational Opportunity Centers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... Agency Information Collection Activities; Comment Request; Educational Opportunity Centers Program (EOC) Annual Performance Report AGENCY: Department of Education (ED), Office of Postsecondary Education (OPE... Opportunity Centers Program (EOC) Annual Performance Report. OMB Control Number: Pending. Type of Review:...

  1. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY... program? Notice of opportunities for assistance to conduct an appraisal investigation or a feasibility... Web site for announcement of Federal assistance opportunities. Opportunities for assistance will...

  2. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY... program? Notice of opportunities for assistance to conduct an appraisal investigation or a feasibility... Web site for announcement of Federal assistance opportunities. Opportunities for assistance will...

  3. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY... program? Notice of opportunities for assistance to conduct an appraisal investigation or a feasibility... Web site for announcement of Federal assistance opportunities. Opportunities for assistance will...

  4. 43 CFR 404.14 - How will Reclamation provide notice of opportunities for assistance under the program?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR RECLAMATION RURAL WATER SUPPLY... program? Notice of opportunities for assistance to conduct an appraisal investigation or a feasibility... Web site for announcement of Federal assistance opportunities. Opportunities for assistance will...

  5. Health Care Providers' Knowledge and Practice Gap towards Joint Zoonotic Disease Surveillance System: Challenges and Opportunities, Gomma District, Southwest Ethiopia

    PubMed Central

    Sime, Abiot Girma; Hajito, Kifle Woldemichael; Gelalacha, Benti Deresa

    2016-01-01

    Background. Health care providers play a crucial role for realization of joint zoonotic diseases surveillance by human and animal health sectors, yet there is limited evidence. Hence, this study aimed to determine knowledge and practice gap of health care providers towards the approach for Rabies and Anthrax in Southwest Ethiopia. Methods. A cross-sectional survey was conducted from December 16, 2014, to January 14, 2015. Eligible health care providers were considered for the study. Data were entered in to Epi-data version 3.1 and analyzed using SPSS version 20. Results. A total of 323 (92.02%) health care providers participated in the study. Three hundred sixteen (97.8%) of participants reported that both human and animal health sectors can work together for zoonotic diseases while 96.9% of them replied that both sectors can jointly conduct surveillance. One hundred seventeen (36.2%) of them reported that their respective sectors had conducted joint surveillance for zoonotic diseases. Their involvement was, however, limited to joint outbreak response. Conclusion. There is good opportunity in health care providers' knowledge even though the practice was unacceptably low and did not address all surveillance components. Therefore, formal joint surveillance structure should be in place for optimal implementation of surveillance. PMID:27579311

  6. Opportunities for Public Health to Increase Physical Activity Among Youths

    PubMed Central

    Dorn, Joan M.; Fulton, Janet E.; Janz, Kathleen F.; Lee, Sarah M.; McKinnon, Robin A.; Pate, Russell R.; Pfeiffer, Karin A.; Young, Deborah Rohm; Troiano, Richard P.; Lavizzo-Mourey, Risa

    2015-01-01

    Despite the well-known benefits of youths engaging in 60 or more minutes of daily physical activity, physical inactivity remains a significant public health concern. The 2008 Physical Activity Guidelines for Americans (PAG) provides recommendations on the amount of physical activity needed for overall health; the PAG Midcourse Report (2013) describes effective strategies to help youths meet these recommendations. Public health professionals can be dynamic change agents where youths live, learn, and play by changing environments and policies to empower youths to develop regular physical activity habits to maintain throughout life. We have summarized key findings from the PAG Midcourse Report and outlined actions that public health professionals can take to ensure that all youths regularly engage in health-enhancing physical activity. PMID:25602864

  7. Promoting physical activity and reducing climate change: opportunities to replace short car trips with active transportation.

    PubMed

    Maibach, Edward; Steg, Linda; Anable, Jillian

    2009-10-01

    Automobile use is a significant contributor to climate change, local air pollution, pedestrian injuries and deaths, declines in physical activity and obesity. A significant proportion of car use is for short trips that can relatively easily be taken with active transportation options--walking or cycling--or with public transportation. In this commentary, we review a number of immediate, practical opportunities to implement policies and programs that reduce short car trips and increase active transportation.

  8. 76 FR 15049 - Agency Information Collection (Equal Opportunity Compliance Review Report); Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... AFFAIRS Agency Information Collection (Equal Opportunity Compliance Review Report); Activity Under OMB... . (Please refer to ``OMB Control No. 2900-0455).'' SUPPLEMENTARY INFORMATION: Titles: a. Equal Opportunity Compliance Review Report, VA Form 20-8734. b. Supplement to Equal Opportunity Compliance Review Report,...

  9. Continuous quality improvement programs provide new opportunities to drive value innovation initiatives in hospital-based radiology practices.

    PubMed

    Steele, Joseph R; Schomer, Don F

    2009-07-01

    Imaging services constitute a huge portion of the of the total dollar investment within the health care enterprise. Accordingly, this generates competition among medical specialties organized along service lines for their pieces of the pie and increased scrutiny from third-party payers and government regulators. These market and political forces create challenge and opportunity for a hospital-based radiology practice. Clearly, change that creates or builds greater value for patients also creates sustainable competitive advantage for a radiology practice. The somewhat amorphous concept of quality constitutes a significant value driver for innovation in this scenario. Quality initiatives and programs seek to define and manage this amorphous concept and provide tools for a radiology practice to create or build more value. Leadership and the early adoption of these inevitable programs by a radiology practice strengthens relationships with hospital partners and slows the attrition of imaging service lines to competitors.

  10. Private Training Providers: Their Characteristics and Training Activities. Support Document

    ERIC Educational Resources Information Center

    Harris, Roger; Simons, Michele; McCarthy, Carmel

    2006-01-01

    This document was produced by the authors based on their research for the report, "Private Training Providers: Their Characteristics and Training Activities," [ED495181] and is an added resource for further information. That study examined the nature of the training activity of private registered training organisations (RTOs) offered to…

  11. Biological Model Development as an Opportunity to Provide Content Auditing for the Foundational Model of Anatomy Ontology

    PubMed Central

    Wang, Lucy L.; Grunblatt, Eli; Jung, Hyunggu; Kalet, Ira J.; Whipple, Mark E.

    2015-01-01

    Constructing a biological model using an established ontology provides a unique opportunity to perform content auditing on the ontology. We built a Markov chain model to study tumor metastasis in the regional lymphatics of patients with head and neck squamous cell carcinoma (HNSCC). The model attempts to determine regions with high likelihood for metastasis, which guides surgeons and radiation oncologists in selecting the boundaries of treatment. To achieve consistent anatomical relationships, the nodes in our model are populated using lymphatic objects extracted from the Foundational Model of Anatomy (FMA) ontology. During this process, we discovered several classes of inconsistencies in the lymphatic representations within the FMA. We were able to use this model building opportunity to audit the entities and connections in this region of interest (ROI). We found five subclasses of errors that are computationally detectable and resolvable, one subclass of errors that is computationally detectable but unresolvable, requiring the assistance of a content expert, and also errors of content, which cannot be detected through computational means. Mathematical descriptions of detectable errors along with expert review were used to discover inconsistencies and suggest concepts for addition and removal. Out of 106 organ and organ parts in the ROI, 8 unique entities were affected, leading to the suggestion of 30 concepts for addition and 4 for removal. Out of 27 lymphatic chain instances, 23 were found to have errors, with a total of 32 concepts suggested for addition and 15 concepts for removal. These content corrections are necessary for the accurate functioning of the FMA and provide benefits for future research and educational uses. PMID:26958311

  12. Legal considerations and cooperative opportunities for space commercial activities

    NASA Technical Reports Server (NTRS)

    Hosenball, S. N.

    1984-01-01

    It is a national policy to make the capabilities of the Space Transportation System available to a wide range of potential users. This includes its availability as a space manufacturing facility for commercial activities, which may be carried out on a reimbursable basis or as a joint endeavor with NASA, but with substantial private investment. In any high risk, long lead-time research and development activity directed towards commercialization, the protection afforded the results of the research and development under the laws relating to intellectual property rights may provide an important incentive for private investment. The policies and practices of NASA directed towards the protection of privately-established intellectual property rights involved in STS use are reviewed with particular emphasis on reimbursable launch agreements and joint endeavor agreements.

  13. Aerobic Activity--Do Physical Education Programs Provide Enough?

    ERIC Educational Resources Information Center

    McGing, Eileen

    1989-01-01

    High school physical education curricula should concentrate less on sport skill development and competition, and more on health-related fitness and aerobic activity. Results are reported from a study of the type and amount of aerobic exercise provided in 29 high school physical education programs in a large metropolitan area. (IAH)

  14. Surface interactions with compartmentalized cellular phosphates explain rare earth oxide nanoparticle hazard and provide opportunities for safer design.

    PubMed

    Li, Ruibin; Ji, Zhaoxia; Chang, Chong Hyun; Dunphy, Darren R; Cai, Xiaoming; Meng, Huan; Zhang, Haiyuan; Sun, Bingbing; Wang, Xiang; Dong, Juyao; Lin, Sijie; Wang, Meiying; Liao, Yu-Pei; Brinker, C Jeffrey; Nel, Andre; Xia, Tian

    2014-02-25

    Growing international exploitation of rare earth oxides (REOs) for commercial and biological use has increased the possibility of human exposure and adverse health effects. Occupational exposure to rare earth materials in miners and polishers leads to a severe form of pneumoconiosis, while gadolinium-containing MRI contrast agents cause nephrogenic systemic fibrosis in patients with renal impairment. The mechanisms for inducing these adverse pro-fibrogenic effects are of considerable importance for the safety assessment of REO particles as well as presenting opportunities for safer design. In this study, using a well-prepared REO library, we obtained a mechanistic understanding of how REOs induce cellular and pulmonary damage by a compartmentalized intracellular biotransformation process in lysosomes that results in pro-fibrogenic growth factor production and lung fibrosis. We demonstrate that rare earth oxide ion shedding in acidifying macrophage lysosomes leads to biotic phosphate complexation that results in organelle damage due to stripping of phosphates from the surrounding lipid bilayer. This results in nanoparticle biotransformation into urchin shaped structures and setting in motion a series of events that trigger NLRP3 inflammasome activation, IL-1β release, TGF-β1 and PDGF-AA production. However, pretreatment of REO nanoparticles with phosphate in a neutral pH environment prevents biological transformation and pro-fibrogenic effects. This can be used as a safer design principle for producing rare earth nanoparticles for biological use.

  15. Association between Social and Environmental Factors and Physical Activity Opportunities in Middle Schools

    ERIC Educational Resources Information Center

    Xu, Furong; Chepyator-Thomson, Jepkorir; Liu, Wenhao; Schmidlein, Robert

    2010-01-01

    School-based physical activity (PA) interventions impact children's PA involvement and thus opportunities and associated factors for the promotion of physical activity in children need to be examined. The purpose of this study was to examine physical education teachers' perceptions of PA opportunities available to students at the middle school…

  16. Duration of suicide process among suicide attempters and characteristics of those providing window of opportunity for intervention

    PubMed Central

    Kattimani, Shivanand; Sarkar, Siddharth; Menon, Vikas; Muthuramalingam, Avin; Nancy, Premkumar

    2016-01-01

    Background: There is limited cross-cultural literature on the duration of suicide process among attempters. Aims: The primary aim was to assess the duration of suicide process among suicide attempters attending the Crisis Intervention Clinic. We also aimed to identify the characteristics of those who reported a longer duration for this process. Methods: In this retrospective record-based study, we collected the duration of the suicidal process from the records of all the suicide attempters evaluated over a 3-year period (n = 319). Attempters were divided into four groups based on the quartile value of the duration of the suicidal process. For analysis, the characteristics of those in the last quartile with suicide process time of >120 min (n = 75) were compared with those in the first three (n = 244). Those in the last quartile were considered to provide a window of opportunity for intervention. Results: The median time for the suicidal process was 30 min (interquartile range of 5 min to 120 min). Seventy-five (23.5%) subjects belonged to the fourth quartile (duration of suicide process >120 min). A significant proportion of them came from urban areas (P = 0.011), had a diagnosis of mood disorder (P = 0.028), had visited a health professional in the recent past (P = 0.015), and had lower rates of attempt under intoxication (P = 0.005). A lesser proportion of them showed problem-focused disengagement style of coping strategy (P = 0.015). Conclusions: The suicide process time among Indian suicide attempters is short. However, a quarter of them has suicide process duration of 2 h which provides some scope for intervention. Individual and community level interventions need further evaluation for their potential efficacy in preventing the progress of the suicidal process. PMID:27695238

  17. The ATS Web Page Provides "Tool Boxes" for: Access Opportunities, Performance, Interfaces, Volume, Environments, "Wish List" Entry and Educational Outreach

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This viewgraph presentation gives an overview of the Access to Space website, including information on the 'tool boxes' available on the website for access opportunities, performance, interfaces, volume, environments, 'wish list' entry, and educational outreach.

  18. Sun protection provided by regulation school uniforms in Australian schools: an opportunity to improve personal sun protection during childhood.

    PubMed

    Turner, Denise; Harrison, Simone L

    2014-01-01

    Childhood sun exposure is linked to excessive pigmented mole development and melanoma risk. Clothing provides a physical barrier, protecting skin from ultraviolet radiation (UVR). Extending sleeves to elbow length and shorts to knee length has been shown to significantly reduce mole acquisition in preschoolers from tropical Queensland. We used publicly available uniform images and guidelines from primary schools in Townsville (latitude 19.25°S, n = 43 schools), Cairns (16.87°S, n = 46) and the Atherton Tablelands (17.26°S, n = 23) in tropical Australia to objectively determine the body surface proportion covered by regulation school uniforms. Uniforms of nongovernment, large (≥800 students), urban, educationally advantaged schools with comprehensive sun protection policies covered more skin than those of government schools (63.2% vs 62.0%; P < 0.001), smaller schools (63.4% vs 62.3%; P = 0.009), rural (62.7% vs 61.9%; P = 0.002) and educationally disadvantaged schools (62.8% vs 62.3%; P < 0.001) with underdeveloped sun protection policies (62.8% vs 62.2%; P = 0.002). Overall, SunSmart and non-SunSmart school uniforms covered identical body surface proportions (62.4%, P = 0.084). Although wearing regulation school uniforms is mandatory at most Australian primary schools, this opportunity to improve children's sun protection is largely overlooked. Recent evidence suggests that even encouraging minor alterations to school uniforms (e.g. slightly longer sleeves/dresses/skirts/shorts) to increase skin coverage may reduce mole acquisition and melanoma risk, especially in high-risk populations.

  19. The copper intrauterine device for emergency contraception: an opportunity to provide the optimal emergency contraception method and transition to highly effective contraception.

    PubMed

    Dermish, Amna I; Turok, David K

    2013-07-01

    Worldwide, 40% of all pregnancies are unintended. Widespread, over-the-counter availability of oral emergency contraception (EC) has not reduced unintended pregnancy rates. The EC visit presents an opportunity to initiate a highly effective method of contraception in a population at high risk of unintended pregnancy who are actively seeking to avoid pregnancy. The copper intrauterine device (IUD), the most effective method of EC, continues to provide contraception as effective as sterilization for up to 12 years, and it should be offered as the first-line method of EC wherever possible. Increased demand for and supply of the copper IUD for EC may have an important role in reducing rates of unintended pregnancy. The EC visit should include access to the copper IUD as optimal care but should ideally include access to all highly effective methods of contraception.

  20. 78 FR 26650 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: African Growth and... comment on an information collection requirement concerning the African Growth and Opportunity Act...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  1. 78 FR 42103 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: African Growth and... accordance with the Paperwork Reduction Act: African Growth and Opportunity Act Certificate of Origin (AGOA...: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form Number:...

  2. 75 FR 9423 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: African Growth and... requirement concerning the African Growth and Opportunity Act Certificate of Origin (AGOA). This request for...: Title: African Growth and Opportunity Act Certificate of Origin. OMB Number: 1651-0082. Form...

  3. 75 FR 26974 - Agency Information Collection Activities: African Growth and Opportunity Act Certificate of Origin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... SECURITY Customs and Border Protection Agency Information Collection Activities: African Growth and... review and approval in accordance with the Paperwork Reduction Act: African Growth and Opportunity Act... forms of information. Title: African Growth and Opportunity Act Certificate of Origin. OMB Number:...

  4. Helping Dysfunctional Recovering Drug-Addicted Mothers To Build Healthy Families by Enhancing Parenting Skills and Providing Opportunities for Bonding.

    ERIC Educational Resources Information Center

    Wilson, Nan Kelly

    This practicum was designed to enhance the parenting skills of drug-addicted recovering women (N=8) and to give opportunities for successful family experiences in a half-way house setting. A curriculum was developed, weekly group meetings were held, guest speakers were presented, mothers were assisted with individual problems, and the program was…

  5. Providing Opportunities for Student Self-Assessment: The Impact on the Acquisition of Psychomotor Skills in Occupational Therapy Students

    ERIC Educational Resources Information Center

    Jay, Julie; Owen, Antonette

    2016-01-01

    The Occupational Therapy department at the University of the Witwatersrand in South Africa is responsible for ensuring students achieve psychomotor skill proficiency, as it is an essential component of health care practice. The aim of this study was to determine whether the introduction of opportunities to afford self-evaluation better prepared…

  6. Reverse Inclusion: Providing Peer Social Interaction Opportunities to Students Placed in Self-Contained Special Education Classrooms

    ERIC Educational Resources Information Center

    Schoger, Kimberly D.

    2006-01-01

    The social and academic benefits of inclusion for students with disabilities have been well researched and well documented. Unfortunately, inclusion opportunities are limited by lack of qualified staff, logistics, scheduling and other difficulties encountered when attempting to meet students' unique needs in the general education setting. As a…

  7. 76 FR 164 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... Haitian Hemispheric Opportunity through Partnership Encouragement (``Haiti HOPE'') Act of 2006. This is a.... Title: Haitian Hemispheric Opportunity through Partnership Encouragement (``Haiti HOPE'') Act of 2006... Partnership Encouragement Act of 2006 (``Haiti HOPE Act''), provides for duty-free treatment for...

  8. Metaproteomics Provides Functional Insight into Activated Sludge Wastewater Treatment

    PubMed Central

    Wilmes, Paul; Wexler, Margaret; Bond, Philip L.

    2008-01-01

    Background Through identification of highly expressed proteins from a mixed culture activated sludge system this study provides functional evidence of microbial transformations important for enhanced biological phosphorus removal (EBPR). Methodology/Principal Findings A laboratory-scale sequencing batch reactor was successfully operated for different levels of EBPR, removing around 25, 40 and 55 mg/l P. The microbial communities were dominated by the uncultured polyphosphate-accumulating organism “Candidatus Accumulibacter phosphatis”. When EBPR failed, the sludge was dominated by tetrad-forming α-Proteobacteria. Representative and reproducible 2D gel protein separations were obtained for all sludge samples. 638 protein spots were matched across gels generated from the phosphate removing sludges. 111 of these were excised and 46 proteins were identified using recently available sludge metagenomic sequences. Many of these closely match proteins from “Candidatus Accumulibacter phosphatis” and could be directly linked to the EBPR process. They included enzymes involved in energy generation, polyhydroxyalkanoate synthesis, glycolysis, gluconeogenesis, glycogen synthesis, glyoxylate/TCA cycle, fatty acid β oxidation, fatty acid synthesis and phosphate transport. Several proteins involved in cellular stress response were detected. Conclusions/Significance Importantly, this study provides direct evidence linking the metabolic activities of “Accumulibacter” to the chemical transformations observed in EBPR. Finally, the results are discussed in relation to current EBPR metabolic models. PMID:18392150

  9. Using time-driven activity-based costing to identify value improvement opportunities in healthcare.

    PubMed

    Kaplan, Robert S; Witkowski, Mary; Abbott, Megan; Guzman, Alexis Barboza; Higgins, Laurence D; Meara, John G; Padden, Erin; Shah, Apurva S; Waters, Peter; Weidemeier, Marco; Wertheimer, Sam; Feeley, Thomas W

    2014-01-01

    As healthcare providers cope with pricing pressures and increased accountability for performance, they should be rededicating themselves to improving the value they deliver to their patients: better outcomes and lower costs. Time-driven activity-based costing offers the potential for clinicians to redesign their care processes toward that end. This costing approach, however, is new to healthcare and has not yet been systematically implemented and evaluated. This article describes early time-driven activity-based costing work at several leading healthcare organizations in the United States and Europe. It identifies the opportunities they found to improve value for patients and demonstrates how this costing method can serve as the foundation for new bundled payment reimbursement approaches.

  10. Department of Energy should provide leadership to assure near-term gasoline-conservation opportunities are realized

    SciTech Connect

    Not Available

    1981-04-13

    The Department of Energy's programs that promote gasoline savings by educating drivers about these conservation opportunities were examined. The methodology employed to review the program is described. Chapter 2 discusses the decline in gasoline consumption and Chapter 3 discusses directions needed to guide development of DOE's near-term gasoline conservation programs. It is recommended that the Secretary of Energy develop a comprehensive strategy to guide DOE's gasoline conservation efforts. (MCW)

  11. 2009 Workplace and Equal Opportunity Survey of Active Duty Members - Tabulation of Responses

    DTIC Science & Technology

    2010-03-30

    Opportunity Survey of Active Duty Members DMDC 469 Percentages 60f . Continued Percent Responding 1 2 3 Max ME Percentage Reporting Yes Officers 51...LIDYDLODEOH0XVWFLWHDWOHDVWWKH\\HDU DQGEH<HDUFRPSOLDQWHJ [[[[[[ 5(32577ɛ(6WDWHWKHW\\ SH RI

  12. 2005 Workplace and Equal Opportunity Survey of Active-Duty Members: Tabulation of Responses

    DTIC Science & Technology

    2007-06-01

    Not reportable 2005 Workplace and Equal Opportunity Survey of Active-Duty Members DMDC 505 Percentages 60f . Continued Percent Responding 1...5(32577ɛ(6WDWHWKHW\\ SH RIUHSRUWVXFKDV ILQDOWHFKQLFDOLQWHULPPHPRUDQGXPPDVWHU V WKHVLVSURJUHVV

  13. Opportunities to Create Active Learning Techniques in the Classroom

    ERIC Educational Resources Information Center

    Camacho, Danielle J.; Legare, Jill M.

    2015-01-01

    The purpose of this article is to contribute to the growing body of research that focuses on active learning techniques. Active learning techniques require students to consider a given set of information, analyze, process, and prepare to restate what has been learned--all strategies are confirmed to improve higher order thinking skills. Active…

  14. Medical Provider Ballistic Protection at Active Shooter Events.

    PubMed

    Stopyra, Jason P; Bozeman, William P; Callaway, David W; Winslow, James; McGinnis, Henderson D; Sempsrott, Justin; Evans-Taylor, Lisa; Alson, Roy L

    2016-01-01

    There is some controversy about whether ballistic protective equipment (body armor) is required for medical responders who may be called to respond to active shooter mass casualty incidents. In this article, we describe the ongoing evolution of recommendations to optimize medical care to injured victims at such an incident. We propose that body armor is not mandatory for medical responders participating in a rapid-response capacity, in keeping with the Hartford Consensus and Arlington Rescue Task Force models. However, we acknowledge that the development and implementation of these programs may benefit from the availability of such equipment as one component of risk mitigation. Many police agencies regularly retire body armor on a defined time schedule before the end of its effective service life. Coordination with law enforcement may allow such retired body armor to be available to other public safety agencies, such as fire and emergency medical services, providing some degree of ballistic protection to medical responders at little or no cost during the rare mass casualty incident. To provide visual demonstration of this concept, we tested three "retired" ballistic vests with ages ranging from 6 to 27 years. The vests were shot at close range using police-issue 9mm, .40 caliber, .45 caliber, and 12-gauge shotgun rounds. Photographs demonstrate that the vests maintained their ballistic protection and defeated all of these rounds.

  15. Practical Opportunities for Healthy Diet and Physical Activity: Relationship to Intentions, Behaviors, and Body Mass Index

    PubMed Central

    Ferrer, Robert L.; Burge, Sandra K.; Palmer, Raymond F.; Cruz, Inez

    2016-01-01

    PURPOSE Current strategies for improving diet and activity patterns focus on encouraging patients to make better choices, but they meet with limited success. Because the choices people make depend on the choices they have, we examined how practical opportunities for diet and physical activity shape behavioral intentions and achieved behaviors. METHODS Participants included 746 adults who visited 8 large primary care practices in the Residency Research Network of Texas in 2012. We used structural equation models to confirm factor structures for a previously validated measure of practical opportunities, and then modeled achieved diet (Starting the Conversation – Diet questionnaire), physical activity (International Physical Activity Questionnaire), and BMI as a function of opportunities (classified as either resources or conversion factors that influence use of resources), behavioral intentions, and demographic covariates. RESULTS In path models, resources (P <.001) and conversion factors (P = .005) predicted behavioral intentions for activity. Conversion factors (P <.001), but not resources, predicted diet intentions. Both activity resources (P = .01) and conversion factors (P <.001) were positively associated with weekly activity minutes. Diet conversion factors (P <.001), but not diet resources (P = .08), were positively associated with diet quality. The same patterns were observed for body mass index (BMI). Socioeconomic gradients in resources and conversion factors were evident. CONCLUSIONS Individuals’ feasible opportunities for healthy diet and activity have clinically meaningful associations with intentions, achieved behaviors, and BMI. Assessing opportunities as part of health behavior management could lead to more effective, efficient, and compassionate interventions. PMID:26951585

  16. How Can I Clarify My Responsibility as a Headteacher as I Provide Opportunities to Enable All Children in the School to Create Talents?

    ERIC Educational Resources Information Center

    Cripps, Louise

    2013-01-01

    In this account I explore and clarify my responsibility as I explain how I have come to my current understanding of talent creation, and why I feel it is so important to develop an inclusive approach to talent creation which provides opportunities for all the children to develop talents through their time at school, and to have them recognised and…

  17. Proveer igualdad de oportunidades educativas para los estudiantes con conocimientos limitados del idioma ingles (Providing Equality of Educational Opportunity for Students with Limited Knowledge of the English Language).

    ERIC Educational Resources Information Center

    Office for Civil Rights (ED), Washington, DC.

    This brochure, entirely in Spanish, provides information on federal policy concerning equal educational opportunity for limited-English-proficient (LEP) individuals. It first summarizes the provisions of Title VI of the 1964 Civil Rights Act, and the subsequent major Civil Rights Office directives concerning that legislation. It then outlines…

  18. 3D design activities at Fermilab: Opportunities for physics

    SciTech Connect

    Yarema, Raymond; Deptuch, Grezgorz; Hoff, Jim; Shenai, Alpana; Trimpl, Marcel; Zimmerman, Tom; Demarteau, Marcel; Liptona, Ron; Christian, Dave; /Fermilab

    2009-01-01

    Fermilab began exploring the technologies for vertically integrated circuits (also commonly known as 3D circuits) in 2006. These technologies include through silicon vias (TSV), circuit thinning, and bonding techniques to replace conventional bump bonds. Since then, the interest within the High Energy Physics community has grown considerably. This paper will present an overview of the activities at Fermilab over the last 3 years which have helped spark this interest.

  19. Play equipment, physical activity opportunities, and children's activity levels at childcare.

    PubMed

    Gubbels, Jessica S; Van Kann, Dave H H; Jansen, Maria W J

    2012-01-01

    This study investigated the association between physical activity facilities at childcare (e.g., play equipment) and physical activity of 2- and 3-year olds. Observations of physical activity intensity were performed among 175 children at 9 childcare centers in The Netherlands, using the OSRAC-P. The physical activity facilities were assessed for indoors and outdoors separately, using the EPAO instrument. Regular (single-level) multivariate and multilevel linear regression analyses examined the association of the facilities and child characteristics (age and sex) with children's activity levels. Various physical activity facilities were available in all childcare centers (e.g., balls). Riding toys and a small playing area were associated with lower indoor physical activity levels. Outdoor physical activity levels were positively associated with the availability of portable jumping equipment and the presence of a structured track on the playground. Portable slides, fixed swinging equipment, and sandboxes were negatively associated with outdoor activity levels. In addition, the 3-year old children were more active outdoors than the 2-year olds. In conclusion, not all physical activity facilities at childcare were indeed positively associated with children's activity levels. The current findings provide concrete leads for childcare providers regarding which factors they can improve in the physical environment to facilitate children's physical activity.

  20. Providing accurate near real-time fire alerts for Protected Areas through NASA FIRMS: Opportunities and Challenges

    NASA Astrophysics Data System (ADS)

    Ilavajhala, S.; Davies, D.; Schmaltz, J. E.; Wong, M.; Murphy, K. J.

    2013-12-01

    The NASA Fire Information for Resource Management System (FIRMS) is at the forefront of providing global near real-time (NRT) MODIS thermal anomalies / hotspot location data to end-users . FIRMS serves the data via an interactive Web GIS named Web Fire Mapper, downloads of NRT active fire, archive data downloads for MODIS hotspots dating back to 1999 and a hotspot email alert system The FIRMS Email Alerts system has been successfully alerting users of fires in their area of interest in near real-time and/or via daily and weekly email summaries, with an option to receive MODIS hotspot data as a text file (CSV) attachment. Currently, there are more than 7000 email alert subscriptions from more than 100 countries. Specifically, the email alerts system is designed to generate and send an email alert for any region or area on the globe, with a special focus on providing alerts for protected areas worldwide. For many protected areas, email alerts are particularly useful for early fire detection, monitoring on going fires, as well as allocating resources to protect wildlife and natural resources of particular value. For protected areas, FIRMS uses the World Database on Protected Areas (WDPA) supplied by United Nations Environment Program - World Conservation Monitoring Centre (UNEP-WCMC). Maintaining the most up-to-date, accurate boundary geometry for the protected areas for the email alerts is a challenge as the WDPA is continuously updated due to changing boundaries, merging or delisting of certain protected areas. Because of this dynamic nature of the protected areas database, the FIRMS protected areas database is frequently out-of-date with the most current version of WDPA database. To maintain the most up-to-date boundary information for protected areas and to be in compliance with the WDPA terms and conditions, FIRMS needs to constantly update its database of protected areas. Currently, FIRMS strives to keep its database up to date by downloading the most recent

  1. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  2. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  3. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  4. 45 CFR 660.8 - How does the Director provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 660.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.8 How does the...

  5. The GILDA t-Infrastructure: grid training activities in Africa and future opportunities

    NASA Astrophysics Data System (ADS)

    Ardizzone, V.; Barbera, R.; Ciuffo, L.; Giorgio, E.

    2009-04-01

    Scientists, educators, and students from many parts of the worlds are not able to take advantage of ICT because the digital divide is growing and prevents less developed countries to exploit its benefits. Instead of becoming more empowered and involved in worldwide developments, they are becoming increasingly marginalised as the world of education and science becomes increasingly Internet-dependent. The Grid Infn Laboratory for Dissemination Activities (GILDA) spreads since almost five years the awareness of Grid technology to a large audience, training new communities and fostering new organisations to provide resources. The knowledge dissemination process guided by the training activities is a key factor to ensure that all users can fully understand the characteristics of the Grid services offered by large existing e-Infrastructure. GILDA is becoming a "de facto" standard in training infrastructures (t-Infrastructures) and it is adopted by many grid projects worldwide. In this contribution we will report on the latest status of GILDA services and on the training activities recently carried out in sub-Saharan Africa (Malawi and South Africa). Particular care will be devoted to show how GILDA can be "cloned" to satisfy both education and research demands of African Organisations. The opportunities to benefit from GILDA in the framework of the EPIKH project as well as the plans of the European Commission on grid training and education for the 2010-2011 calls of its 7th Framework Programme will be presented and discussed.

  6. Isothermal drop calorimeter provides measurements for alpha active, pyrophoric materials

    NASA Technical Reports Server (NTRS)

    Savage, H.

    1969-01-01

    Isothermal drop calorimeter measures the heat content of intensely alpha active and pyrophoric materials in inert atmospheres. It consists of a furnace, calorimeter, and aluminum isothermal jacket contained within an inert-atmosphere glove box, which permits the use of unencapsulated materials without exposing personnel to alpha contamination.

  7. Right Back at 'Cha--Boomerang Activity Provides Educational Returns

    ERIC Educational Resources Information Center

    Campbell, Brian

    2012-01-01

    Motivating students to get actively involved in the curriculum and understand the application of academic content has been a challenge for many educators. Technology education instructors have traditionally had little difficulty showing their students the connection between their classroom and lab learning and a practical application of the skills…

  8. 45 CFR 100.8 - How does the Secretary provide states an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 100.8 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF HEALTH AND HUMAN SERVICES PROGRAMS AND ACTIVITIES § 100.8 How does the Secretary... the review, coordination, and communication with the Department have been delegated. (c)...

  9. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  10. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  11. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  12. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  13. 40 CFR 29.8 - How does the Administrator provide States an opportunity to comment on proposed Federal financial...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...? 29.8 Section 29.8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.8 How does the Administrator... communication with the Environmental Protection Agency have been delegated. (c) Applicants for programs...

  14. Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.

    PubMed

    Rodova, Mariana; Fu, Junsheng; Watkins, Dara Nall; Srivastava, Rakesh K; Shankar, Sharmila

    2012-01-01

    Dysregulation of the sonic hedgehog (Shh) signaling pathway has been associated with cancer stem cells (CSC) and implicated in the initiation of pancreatic cancer. Pancreatic CSCs are rare tumor cells characterized by their ability to self-renew, and are responsible for tumor recurrence accompanied by resistance to current therapies. The lethality of these incurable, aggressive and invasive pancreatic tumors remains a daunting clinical challenge. Thus, the objective of this study was to investigate the role of Shh pathway in pancreatic cancer and to examine the molecular mechanisms by which sulforaphane (SFN), an active compound in cruciferous vegetables, inhibits self-renewal capacity of human pancreatic CSCs. Interestingly, we demonstrate here that Shh pathway is highly activated in pancreatic CSCs and plays important role in maintaining stemness by regulating the expression of stemness genes. Given the requirement for Hedgehog in pancreatic cancer, we investigated whether hedgehog blockade by SFN could target the stem cell population in pancreatic cancer. In an in vitro model, human pancreatic CSCs derived spheres were significantly inhibited on treatment with SFN, suggesting the clonogenic depletion of the CSCs. Interestingly, SFN inhibited the components of Shh pathway and Gli transcriptional activity. Interference of Shh-Gli signaling significantly blocked SFN-induced inhibitory effects demonstrating the requirement of an active pathway for the growth of pancreatic CSCs. SFN also inhibited downstream targets of Gli transcription by suppressing the expression of pluripotency maintaining factors (Nanog and Oct-4) as well as PDGFRα and Cyclin D1. Furthermore, SFN induced apoptosis by inhibition of BCL-2 and activation of caspases. Our data reveal the essential role of Shh-Gli signaling in controlling the characteristics of pancreatic CSCs. We propose that pancreatic cancer preventative effects of SFN may result from inhibition of the Shh pathway. Thus

  15. Efficiency of Energy Use in the United States: Transportation, space heating, and air conditioning provide opportunities for large energy savings.

    PubMed

    Hirst, E; Moyers, J C

    1973-03-30

    We described three uses of energy for which greater efficiency is feasible: transportation, space heating, and air conditioning. Shifts to less energy-intensive transportation modes could substantially reduce energy consumption; the magnitude of such savings would, of course, depend on the extent of such shifts and possible load factor changes. The hypothetical transportation scenario described here results in a 22 percent savings in energy for transportation in 1970, a savings of 2800 trillion Btu. To the homeowner, increasing the amount of building insulation and, in some cases, adding storm windows would reduce energy consumption and provide monetary savings. If all homes in 1970 had the "economic optimum" amount of insulation, energy consumption for residential heating would have been 42 percent less than if the homes were insulated to meet the pre-1971 FHA standards, a savings of 3100 trillion Btu. Increased utilization of energy-efficient air conditioners and of building insulation would provide significant energy savings and help to reduce peak power demands during the summer. A 67 percent increase in energy efficiency for room air conditioners would have saved 15.8 billion kilowatt-hours in 1970. In conclusion, it is possible-from an engineering point of view-to effect considerable energy savings in the United States. Increases in the efficiency of energy use would provide desired end results with smaller energy inputs. Such measures will not reduce the level of energy consumption, but they could slow energy growth rates.

  16. The ICESat-2 Mission: Concept, Pre-Launch Activities, and Opportunities

    NASA Technical Reports Server (NTRS)

    Markus, Thorsten; Neumann, Tom; Csatho, Beata M.

    2011-01-01

    Ice sheet and sea level changes have been explicitly identified as a priority in the President's Climate Change Science Program, the Arctic Climate Impact Assessment, the 4th Assessment Report of the IPee and other national and international policy documents. Following recommendations from the National Research Council for an ICESat follow-on mission, the ICESat-2 mission is now under development for launch in early 2016. The primary aims of the ICESat-2 mission are to continue measurements of sea-ice thickness change, and ice sheet elevation changes at scales from outlet glaciers to the entire ice sheet as established by ICES at. In contrast to ICES at, ICESat-2 will employ a 6-beam micro-pulse laser photon-counting approach. The current concept uses a high repetition rate (10 kHz; equivalent to 70 cm on the ground) low-power laser in conjunction with single-photon sensitive detectors to measure range using approximately 532nm (green) light. The concept will enable the generation of seasonal maps of ice sheet elevation of Greenland and Antarctica, monthly maps of sea ice thickness of the polar ocean, a dense map of land elevation (2 km track spacing at the equator after two years) enabling the determination of canopy height, as well as ocean heights. While the mission has been optimized for cryospheric science and vast amount of high precision elevation measurements taken over land and over the ocean as well as of the atmosphere will provide scientists with a wealth of opportunities to explore the utility of ICESat-2. Those will range from the retrieval of cloud properties, to river stages, to snow cover, to land use changes and more. The presentation will review the measurement concept and physical principles of ICESat-2, current and planned activities to assess instrument performance and develop geophysical algorithms, as well as potential opportunities outside the main objectives of ICESat-2.

  17. The ICESat-2 Mission: Concept, pre-launch activities, and opportunities

    NASA Astrophysics Data System (ADS)

    Markus, T.; Neumann, T.; Csatho, B. M.

    2011-12-01

    Ice sheet and sea level changes have been explicitly identified as a priority in the President's Climate Change Science Program, the Arctic Climate Impact Assessment, the 4th Assessment Report of the IPCC and other national and international policy documents. Following recommendations from the National Research Council for an ICESat follow-on mission, the ICESat-2 mission is now under development for launch in early 2016. The primary aims of the ICESat-2 mission are to continue measurements of sea-ice thickness change, and ice sheet elevation changes at scales from outlet glaciers to the entire ice sheet as established by ICESat. In contrast to ICESat, ICESat-2 will employ a 6-beam micro-pulse laser photon-counting approach. The current concept uses a high repetition rate (10 kHz; equivalent to 70 cm on the ground) low-power laser in conjunction with single-photon sensitive detectors to measure range using ~532nm (green) light. The concept will enable the generation of seasonal maps of ice sheet elevation of Greenland and Antarctica, monthly maps of sea ice thickness of the polar ocean, a dense map of land elevation (2 km track spacing at the equator after two years) enabling the determination of canopy height, as well as ocean heights. While the mission has been optimized for cryospheric science and vast amount of high precision elevation measurements taken over land and over the ocean as well as of the atmosphere will provide scientists with a wealth of opportunities to explore the utility of ICESat-2. Those will range from the retrieval of cloud properties, to river stages, to snow cover, to land use changes and more. The presentation will review the measurement concept and physical principles of ICESat-2, current and planned activities to assess instrument performance and develop geophysical algorithms, as well as potential opportunities outside the main objectives of ICESat-2.

  18. The Effect of Active Support Training on Engagement, Opportunities for Choice, Challenging Behaviour and Support Needs

    ERIC Educational Resources Information Center

    Koritsas, Stella; Iacono, Teresa; Hamilton, David; Leighton, Daniel

    2008-01-01

    Background: The aim of this study was to evaluate active support (AS) training and to investigate changes to perceived engagement in domestic tasks, opportunities for choice, frequency of challenging behaviour, and level of support needs. Method: Participants were 12 adults with ID aged 27-57 years (M = 37 years) residing in three group homes, and…

  19. 75 FR 67753 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... of 2006 (``Haiti HOPE Act''). This request for comment is being made pursuant to the Paperwork...: Title: Haitian Hemispheric Opportunity through Partnership Encouragement (``Haiti HOPE'') Act of 2006... Partnership Encouragement Act of 2006 (``Haiti HOPE Act''), provides for duty-free treatment for...

  20. Whole Blood Metabolomics by (1)H NMR Spectroscopy Provides a New Opportunity To Evaluate Coenzymes and Antioxidants.

    PubMed

    Nagana Gowda, G A; Raftery, Daniel

    2017-03-30

    Conventional human blood metabolomics employs serum or plasma and provides a wealth of metabolic information therein. However, this approach lacks the ability to measure and evaluate important metabolites such as coenzymes and antioxidants that are present at high concentrations in red blood cells. As an important alternative to serum/plasma metabolomics, we show here that a simple (1)H NMR experiment can simultaneously measure coenzymes and antioxidants in extracts of whole human blood, in addition to the nearly 70 metabolites that were shown to be quantitated in serum/plasma recently [ Anal. Chem. 2015 , 87 , 706 - 715 ]. Coenzymes of redox reactions: oxidized/reduced nicotinamide adenine dinucleotide (NAD(+) and NADH) and nicotinamide adenine dinucleotide phosphate (NADP(+) and NADPH); coenzymes of energy including adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP); and antioxidants, the sum of oxidized and reduced glutathione (GSSG and GSH) can be measured with essentially no additional effort. A new method was developed for detecting many of these unstable species without affecting other blood/blood plasma metabolites. The identities of coenzymes and antioxidants in blood NMR spectra were established combining 1D/2D NMR techniques, chemical shift databases, pH measurements and, finally, spiking with authentic compounds. This is the first study to report identification of major coenzymes and antioxidants and quantify them, simultaneously, with the large pool of other metabolites in human blood using NMR spectroscopy. Considering that the levels of coenzymes and antioxidants represent a sensitive measure of cellular functions in health and numerous diseases, the NMR method presented here potentially opens a new chapter in the metabolomics of blood.

  1. Factors associated with time provided to children for physical activity in family child care: a cross-sectional study.

    PubMed

    Figueroa, Roger; Wiley, Angela

    2016-01-01

    Childhood obesity has increased in the past 30 years, and physical inactivity is a major contributor. Factors related to physical activity promotion in the family child care context are understudied. A convenience sample of participants in a mid-sized city in the Midwestern U.S. was recruited through the local child care resource and referral agency and were invited through flyers and emails to take part in an online or paper survey. Survey results in a sample of 107 family child care providers indicate that many did not meet physical activity recommendations and are missing the opportunity to enable children's physical activity via important practices and resources. Provider self-efficacy about being physically active, and indoor physical activity space positively associated with time provided for child physical activity. Health training is negatively associated with time provided for child physical activity. Practice implications include: (1) develop activities that promote physical activity in the tight confines of family child care homes and yard; (2) develop trainings that can influence the integration of suitable portable play equipment in the space constraints of family child care homes (3) Propose creative ideas for active free play even when in a shared space; (4) prioritize providing separate play areas by age group and strategize ways to do this in family child care contexts (for example, alternate access to spaces by age); (5) engage providers and children in joint activities that increase provider physical activity efficacy and physical activity time as well as that of children; (6) promote health and physical activity among family child care providers themselves.

  2. Energy Problems Provide Job Opportunities.

    ERIC Educational Resources Information Center

    Moore, Allen B.

    In response to the problems created by a diminishing energy supply but an increasing energy demand, this second in a series of national reports studies the linkage of vocational education and energy. Through an examination of selected literature with reference to types of energy resources, the author identifies the emerging occupations related to…

  3. Kazakhstan's potential provides Western opportunities

    SciTech Connect

    Darnell, R. )

    1993-01-01

    While crude oil production continues to drop in the Russian Federation at a rate of 15% to 20% per year, Kazakhstan's output rose from 440,000 bopd in 1991 to 446,000 bopd, as of November 1992. Much of this increase was exported to the Russian Federation to supplement the latter's declining production. while Kazakhstan received needed Russian goods in exchange for this oil, it isn't getting the hard currency that will be required to upgrade its petroleum industry. This is a serious problem for Kazakh officials, since they are counting on revenues from petroleum exports to invigorate their overall plan for economic growth in this newly independent country. In order to convert Kazakhstan's hydrocarbon potential into economic reality, two critical issues must be addressed immediately. First, Kazakhstan must develop a tax and minerals law that gives multinational petroleum companies an incentive to invest in opening a dedicated crude oil export route through Russia, and at least one alternate export route to the Caspian Sea or Persian Gulf. At present, even the most successful petroleum venture inside Kazakhstan would have to weave its way through the Russian bureaucracy to utilize that existing and inadequate export pipeline system. This quandary, of course, has recently become the undoing of several Western petroleum operations that have managed to actually produce exportable oil inside the Russian Federation itself, but they can't get it out. In addition, three other variables should be considered by any party that is evaluating Kazakhstan as a future area (see map for current fields) of interest for petroleum operations. These are political stability, field operating conditions, and the country's natural gas crisis. Each of these factors, though not as critical as the legal regime and export access, can radically affect how an operator might approach negotiating the terms of its particular project.

  4. Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design.

    PubMed

    Miglianico, Marie; Nicolaes, Gerry A F; Neumann, Dietbert

    2016-04-14

    As a central regulator of metabolism, the AMP-activated protein kinase (AMPK) is an established therapeutic target for metabolic diseases. Beyond the metabolic area, the number of medical fields that involve AMPK grows continuously, expanding the potential applications for AMPK modulators. Even though indirect AMPK activators are used in the clinics for their beneficial metabolic outcome, the few described direct agonists all failed to reach the market to date, which leaves options open for novel targeting methods. As AMPK is not actually a single molecule and has different roles depending on its isoform composition, the opportunity for isoform-specific targeting has notably come forward, but the currently available modulators fall short of expectations. In this review, we argue that with the amount of available structural and ligand data, computer-based drug design offers a number of opportunities to undertake novel and isoform-specific targeting of AMPK.

  5. Analysis of near-term production and market opportunities for hydrogen and related activities

    SciTech Connect

    Mauro, R.; Leach, S.

    1995-09-01

    This paper summarizes current and planned activities in the areas of hydrogen production and use, near-term venture opportunities, and codes and standards. The rationale for these efforts is to assess industry interest and engage in activities that move hydrogen technologies down the path to commercialization. Some of the work presented in this document is a condensed, preliminary version of reports being prepared under the DOE/NREL contract. In addition, the NHA work funded by Westinghouse Savannah River Corporation (WSRC) to explore the opportunities and industry interest in a Hydrogen Research Center is briefly described. Finally, the planned support of and industry input to the Hydrogen Technical Advisory Panel (HTAP) on hydrogen demonstration projects is discussed.

  6. Expanding Voluntary Active-learning Opportunities for Pharmacy Students in a Respiratory Physiology Module

    PubMed Central

    Ernst, Hardy; Colthorpe, Kay

    2008-01-01

    Objectives To expand voluntary active-learning opportunities for bachelor of pharmacy students enrolled in a third-year human physiology and pharmacology course and determine whether the additional course components improved learning outcomes. Design Additional voluntary active-learning opportunities including a large-class tutorial, additional formative assessment, and an online discussion were added to the Respiratory Physiology Module of the course. Examination scores were compared with those from previous years. A questionnaire was administered to assess students' perception of the active-learning components. Assessment Mean examination scores increased from 69.3% ± 24.4% in 2003 to 88.9% ± 13.4% in 2004 and 86.9% ± 17.6% in 2005, after the addition of the active-learning components. Students' overall perception of the value of the active-learning activities was positive. Summary The addition of voluntary active-learning course components to a required pharmacy course resulted in improved student examination scores, and decreased failure rate, and were accomplished at low cost and with little additional staff time. PMID:18483596

  7. Lost Opportunities to Reduce Periconception HIV Transmission: Safer Conception Counseling By South African Providers Addresses Perinatal but not Sexual HIV Transmission

    PubMed Central

    Milford, Cecilia; Kaida, Angela; Ehrlich, Matthew J.; Ng, Courtney; Greener, Ross; Mosery, F. N.; Harrison, Abigail; Psaros, Christina; Safren, Steven A.; Bajunirwe, Francis; Wilson, Ira B.; Bangsberg, David R.; Smit, Jennifer A.

    2014-01-01

    Introduction: Safer conception strategies create opportunities for HIV-serodiscordant couples to realize fertility goals and minimize periconception HIV transmission. Patient–provider communication about fertility goals is the first step in safer conception counseling. Methods: We explored provider practices of assessing fertility intentions among HIV-infected men and women, attitudes toward people living with HIV (PLWH) having children, and knowledge and provision of safer conception advice. We conducted in-depth interviews (9 counselors, 15 nurses, 5 doctors) and focus group discussions (6 counselors, 7 professional nurses) in eThekwini District, South Africa. Data were translated, transcribed, and analyzed using content analysis with NVivo10 software. Results: Among 42 participants, median age was 41 (range, 28–60) years, 93% (39) were women, and median years worked in the clinic was 7 (range, 1–27). Some providers assessed women's, not men's, plans for having children at antiretroviral therapy initiation, to avoid fetal exposure to efavirenz. When conducted, reproductive counseling included CD4 cell count and HIV viral load assessment, advising mutual HIV status disclosure, and referral to another provider. Barriers to safer conception counseling included provider assumptions of HIV seroconcordance, low knowledge of safer conception strategies, personal feelings toward PLWH having children, and challenges to tailoring safer sex messages. Conclusions: Providers need information about HIV serodiscordance and safer conception strategies to move beyond discussing only perinatal transmission and maternal health for PLWH who choose to conceive. Safer conception counseling may be more feasible if the message is distilled to delaying conception attempts until the infected partner is on antiretroviral therapy. Designated and motivated nurse providers may be required to provide comprehensive safer conception counseling. PMID:25436820

  8. Reframing Perceptions of the Lecture from Challenges to Opportunities: Embedding Active Learning and Formative Assessment into the Teaching of Large Classes

    ERIC Educational Resources Information Center

    Winstone, Naomi; Millward, Lynne

    2012-01-01

    Teaching and assessing large classes can be reframed from focusing on overcoming difficulties with large classes, to seeking the unique educational opportunities provided by such learning environments. We discuss data and examples illustrating how active learning and formative assessment can be successfully embedded into the teaching of large…

  9. Care coordination between specialty care and primary care: a focus group study of provider perspectives on strong practices and improvement opportunities.

    PubMed

    Kim, Bo; Lucatorto, Michelle A; Hawthorne, Kara; Hersh, Janis; Myers, Raquel; Elwy, A Rani; Graham, Glenn D

    2015-01-01

    Care coordination between the specialty care provider (SCP) and the primary care provider (PCP) is a critical component of safe, efficient, and patient-centered care. Veterans Health Administration conducted a series of focus groups of providers, from specialty care and primary care clinics at VA Medical Centers nationally, to assess 1) what SCPs and PCPs perceive to be current practices that enable or hinder effective care coordination with one another and 2) how these perceptions differ between the two groups of providers. A qualitative thematic analysis of the gathered data validates previous studies that identify communication as being an important enabler of coordination, and uncovers relationship building between specialty care and primary care (particularly through both formal and informal relationship-building opportunities such as collaborative seminars and shared lunch space, respectively) to be the most notable facilitator of effective communication between the two sides. Results from this study suggest concrete next steps that medical facilities can take to improve care coordination, using as their basis the mutual understanding and respect developed between SCPs and PCPs through relationship-building efforts.

  10. Tablet and Face-to-Face Hybrid Professional Development: Providing Earth Systems Science Educators Authentic Research Opportunities through The GLOBE Program at Purdue University

    NASA Astrophysics Data System (ADS)

    Wegner, K.; Branch, B. D.; Smith, S. C.

    2013-12-01

    The Global Learning and Observations to Benefit the Environment (GLOBE) program is a worldwide hands-on, primary and secondary school-based science and education program (www.globe.gov). GLOBE's vision promotes and supports students, teachers and scientists to collaborate on inquiry-based authentic science investigations of the environment and the Earth system working in close partnership with NASA, NOAA and NSF Earth System Science Projects (ESSP's) in study and research about the dynamics of Earth's environment. GLOBE Partners conduct face-to-face Professional Development in more than 110 countries, providing authentic scientific research experience in five investigation areas: atmosphere, earth as a system, hydrology, land cover, and soil. This presentation will provide a sample for a new framework of Professional Development that was implemented in July 2013 at Purdue University lead by Mr. Steven Smith who has tested GLOBE training materials for future training. The presentation will demonstrate how institutions can provide educators authentic scientific research opportunities through various components, including: - Carrying out authentic research investigations - Learning how to enter their authentic research data into the GLOBE database and visualize it on the GLOBE website - Learn how to access to NASA's Earth System Science resources via GLOBE's new online 'e-Training Program' - Exploring the connections of their soil protocol measurements and the history of the soil in their area through iPad soils app - LIDAR data exposure, Hydrology data exposure

  11. Financial Opportunities

    SciTech Connect

    2012-01-19

    The Water Power Program focuses on technological development, and deployment of innovative technologies capable of generating electricity from water. The program funds research and development activities through competitive solicitations. Financial opportunities are avaliable here.

  12. Future Opportunities and Challenges with Using Demand Response as a Resource in Distribution System Operation and Planning Activities

    SciTech Connect

    Cappers, Peter; MacDonald, Jason; Page, Janie; Potter, Jennifer; Stewart, Emma

    2016-01-01

    This scoping study focuses on identifying the ability for current and future demand response opportunities to contribute to distribution system management. To do so, this scoping study will identify the needs of a distribution system to operate efficiently, safely and reliably; summarize both benefits and challenges for the operation of the distribution system with high penetration levels of distributed energy resources; define a suite of services based on those changing operational needs that could be provided by resources; identify existing demand response opportunities sponsored by distribution utilities and/or aggregators of retail customers; assess the extent to which distribution system services can be provided via DR opportunities both in their current form and with alterations to their design; and provide a qualitative assessment of coordination issues that bulk power and distribution system providers of DR opportunities will need to address.

  13. Social Support and Youth Physical Activity: The Role of Provider and Type

    ERIC Educational Resources Information Center

    Beets, Michael W.; Vogel, Randy; Forlaw, Loretta; Pitetti, Kenneth H.; Cardinal, Bradley J.

    2006-01-01

    Objective: To examine provider and type variation in social support (SS) for activity. Methods: Three hundred sixty-three fifth to eighth-grade students completed a questionnaire assessing self-reported activity and social support (SS) from 3 providers: mom, dad, and peers. Important covariates of activity were included in the analysis: age, BMI,…

  14. Windows of opportunity for physical activity in the prevention of obesity.

    PubMed

    Street, S J; Wells, J C K; Hills, A P

    2015-10-01

    Tackling increasing rates of obesity is likely to be a defining feature of health care over the next several decades. Adult obesity is a persistent and treatment-resistant problem. Consequently, an emerging theme in the literature is to commence prevention efforts earlier in the developmental time course. This view is based primarily on epidemiological data demonstrating a link between traits manifesting early during development and increased obesity risk in adulthood. Physical activity is a perennial factor in discussions of obesity prevention. However, the optimal timing and type of physical activity interventions to commence remains unclear. Critical developmental windows of plasticity may afford time-limited opportunities to shape body composition across the life course; however, physical activity has not been explicitly considered in these discussions. Although animal models suggest that physical activity commenced earlier in development has differential effects on obesity onset compared to physical activity commenced in adulthood, human research is lacking. In this conceptual review, we consider physical activity during critical developmental periods as a way to mitigate obesity risk later in life.

  15. Challenging Opportunities for Special Populations in Aquatic, Outdoor and Winter Activities.

    ERIC Educational Resources Information Center

    American Alliance for Health, Physical Education, and Recreation, Washington, DC. Information and Research Utilization Center.

    The resource guide provides information on challenging and adventurous physical activities for handicapped persons. References for printed materials, audiovisual materials, and special equipment or assistive devices are listed for aquatics, winter activities, and outdoor activities (bicycling, fishing, hiking and nature trails, horseback riding,…

  16. Social media: opportunities for quality improvement and lessons for providers-a networked model for patient-centered care through digital engagement.

    PubMed

    Bornkessel, Alexandra; Furberg, Robert; Lefebvre, R Craig

    2014-07-01

    Social media brings a new dimension to health care for patients, providers, and their support networks. Increasing evidence demonstrates that patients who are more actively involved in their healthcare experience have better health outcomes and incur lower costs. In the field of cardiology, social media are proposed as innovative tools for the education and update of clinicians, physicians, nurses, and medical students. This article reviews the use of social media by healthcare providers and patients and proposes a model of "networked care" that integrates the use of digital social networks and platforms by both patients and providers and offers recommendations for providers to optimize their use and understanding of social media for quality improvement.

  17. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... curriculum. (f) Providing special programs or tutoring in science, technology, engineering, or mathematics... counseling, and home visits. (10) Staff development. (11) Programs and activities that are specially...

  18. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... curriculum. (f) Providing special programs or tutoring in science, technology, engineering, or mathematics... counseling, and home visits. (10) Staff development. (11) Programs and activities that are specially...

  19. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Additional provider and supplier requirements for... Billing Privileges § 424.516 Additional provider and supplier requirements for enrolling and maintaining... active enrollment status for a provider or supplier when that provider or supplier certifies that...

  20. The relative effect of health literacy and patient activation on provider choice in the Netherlands.

    PubMed

    Rademakers, Jany; Nijman, Jessica; Brabers, Anne E M; de Jong, Judith D; Hendriks, Michelle

    2014-02-01

    Active provider choice by patients has become an important policy theme in western, countries over the last decades. However, not many patients and consumers exercise their right to, choose. Both health literacy and patient activation are likely to have an impact on the choice process. In, this article the relative effect of health literacy and patient activation on provider choice in the, Netherlands is studied. A questionnaire was sent to a representative sample of 2000 Dutch citizens. The questionnaire, included a measure of functional health literacy, the Dutch version of the Patient Activation Measure, and questions assessing active provider choice, reasons not to engage in it and other ways of provider, selection. The majority of respondents (59.6%) would not search for information on the basis of which they, could select the best provider or hospital. Most people rely on their general practitioner's advice. Both, low literacy and lower patient activation levels were negatively associated with active provider choice. In a regression analysis gender, education and patient activation proved the most important, predictors. The policy focus on active provider choice might result in inequity, with men, less educated, and less activated people being at a disadvantage.

  1. Steps for Improving Physical Activity Orientation Among Health-care Providers of Older Cardiovascular Patients

    PubMed Central

    2014-01-01

    Attaining appropriate levels of physical activity can have many potential physiological and psychological benefits in older adults with cardiovascular disease. However, these individuals often report low levels of physical activity and high levels of sedentary behavior. Older adults encounter many potential “barriers” to physical activity, but numerous studies have demonstrated the ability to positively influence this important health behavior using well-established behavior change theories and models. The information provided in this review is directed at health-care providers who have the potential to impact physical activity behaviors during regular, often brief, clinical interactions. In addition to providing the latest physical activity recommendations, this update will provide a brief summary of some of the more widely used behavioral skills and strategies for promoting physical activity in older adults with cardiovascular disease. PMID:25396112

  2. 75 FR 9431 - Small and Medium-Sized Enterprises: U.S. and EU Export Activities, and Barriers and Opportunities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Small and Medium-Sized Enterprises: U.S. and EU Export Activities, and Barriers and Opportunities... investigations, investigation No. 332-509, Small and Medium-Sized Enterprises: U.S. and EU Export Activities,...

  3. Pupil's Opportunities to Influence Activities: A Study of Everyday Practice at a Swedish Leisure-Time Centre

    ERIC Educational Resources Information Center

    Haglund, Björn

    2015-01-01

    The focal point of this article is a discussion of pupils' opportunities to make their voices heard and influence the activity in a Swedish leisure-time centre. The study comprises six weeks of ethnographically inspired field work including data from participating observations and walk-and-talk conversations. Two voluntary activities, referred to…

  4. Situating Ontario's Colleges between the American and European Models for Providing Opportunity for the Attainment of Baccalaureate Degrees in Applied Fields of Study

    ERIC Educational Resources Information Center

    Skolnik, Michael L.

    2016-01-01

    During the last third of the twentieth century, college sectors in many countries took on the role of expanding opportunities for baccalaureate degree attainment in applied fields of study. In many European countries, colleges came to constitute a parallel higher education sector that offered degree programs of an applied nature in contrast to the…

  5. Equality or Equity, Player or Guardian? The Dutch Government and Its Role in Providing Access Opportunities for Government Sponsored International Secondary Education, 1979-2009

    ERIC Educational Resources Information Center

    Prickarts, Boris

    2010-01-01

    This article focuses on the Dutch government's International Baccalaureate (IB) Diploma Programme (DP) Pilot, allowing Dutch pre-university students to take part in the IB DP. Is it likely to create "equal", or rather "equitable", access opportunities for government-sponsored Dutch international secondary schools? The article…

  6. Activities.

    ERIC Educational Resources Information Center

    Bippert, Judy

    1993-01-01

    Presents activities designed to give students an opportunity to solve concrete problems involving spatial relationships and logical thinking utilizing hands-on manipulatives. Provides teacher instructions and four reproducible worksheets. (MDH)

  7. Medical Care Provided Under California's Workers' Compensation Program: Effects of the Reforms and Additional Opportunities to Improve the Quality and Efficiency of Care.

    PubMed

    Wynn, Barbara O; Timbie, Justin W; Sorbero, Melony E

    2011-01-01

    Since 2004, significant changes have been made to the California workers' compensation (WC) system. The Commission on Health and Safety and Workers' Compensation (CHSWC) asked the RAND Corporation to examine the impact that these changes have on the medical care provided to injured workers. This study synthesizes findings from interviews and available information regarding the implementation of the changes affecting WC medical care and identifies areas in which additional changes might increase the quality and efficiency of care delivered under the WC system. To improve incentives for efficiently providing medically appropriate care, California should revise its fee schedule allowances for services provided by hospitals to inpatients, freestanding ambulatory surgery centers, and physicians, create nonmonetary incentives for providing medically appropriate care in the medical provider network (MPN) context through more-selective contracting with providers and reducing medical review requirements for high-performing physicians; reduce incentives for inappropriate prescribing practices by curtailing in-office physician dispensing; and implement pharmacy benefit network regulations. To increase accountability for performance, California should revise the MPN certification process to place accountability for meeting MPN standards on the entity contracting with the physician network; strengthen Division of Workers' Compensation (DWC) authorities to provide intermediate sanctions for failure to comply with MPN requirements; and modify the Labor Code to remove payers and MPNs from the definition of individually identifiable data so that performance on key measures can be publicly available. To facilitate monitoring and oversight, California should provide DWC with more flexibility to add needed data elements to medical data reporting and provide penalties for a claim administrator failing to comply with the data-reporting requirements; require that medical cost

  8. Environmental factors: opportunities and barriers for physical activity, and healthy eating among children and adolescents.

    PubMed

    Huybrechts, I; De Bourdeaudhuij, I; De Henauw, S

    2010-01-01

    While genetic factors play a role in the development of obesity, the dramatic increase of its prevalence in the past years strongly suggests that environmental factors are largely responsible. The wealth and variety of food supply available 24h/day and throughout the year, the change in dietary habits due to time constraints and the change in physical activity due to technological advances all create a 'toxic' environment responsible for obesity and eating habit disorders. This manuscript describes and discusses the results of a systematic review of environmental opportunities & obstacles for physical activity and dietary intake influencing the obesity epidemic among children and adolescents. Although evidence clearly shows the impact of the environment on obesity related lifestyle factors, evidence for effective strategies combating this obesogenic environment is very scarce. Interventions aiming to change environmental factors in order to reduce obesity may include taxes/subsidies encouraging healthy eating or physical activity, extra provision of sporting facilities, efforts to improve safety and accessibility of walking, cycling or play areas or attempting to influence social meanings/values attached to weight, food or physical activity. It is clear that some level of institutionalization of systems that support the desired changes is required to sustain environmental and social changes in the long-term. At last, it is important to note that better-designed and -conducted research on the true importance of the interaction between environmental factors and psychosocial factors, including the micro- and the macro-level, for obesogenic behavioral change is needed to reassure the success of large-scale environmental change interventions.

  9. Using existing programs as vehicles to disseminate knowledge, provide opportunities for scientists to assist educators, and to engage students in using real data

    NASA Astrophysics Data System (ADS)

    Smith, S. C.; Wegner, K.; Branch, B. D.; Miller, B.; Schulze, D. G.

    2013-12-01

    Many national and statewide programs throughout the K-12 science education environment teach students about science in a hands-on format, including programs such as Global Learning and Observations to Benefit the Environment (GLOBE), Project Learning Tree (PLT), Project Wild, Project Wet, and Hoosier River Watch. Partnering with one or more of these well-known programs can provide many benefits to both the scientists involved in disseminating research and the K-12 educators. Scientists potentially benefit by broader dissemination of their research by providing content enrichment for educators. Educators benefit by gaining understanding in content, becoming more confident in teaching the concept, and increasing their enthusiasm in teaching the concepts addressed. This presentation will discuss an innovative framework for professional development that was implemented at Purdue University, Indiana in July 2013. The professional development incorporated GLOBE protocols with iPad app modules and interactive content sessions from faculty and professionals. By collaborating with the GLOBE program and scientists from various content areas, the Department of Earth, Atmospheric, and Planetary Sciences at Purdue University successfully facilitated a content rich learning experience for educators. Such activity is promoted and supported by Purdue University Libraries where activities such as Purdue's GIS Day are efforts of making authentic learning sustainable in the State of Indiana and for national consideration. Using iPads to visualize soil transitions on a field trip. Testing Water quality in the field.

  10. "Because I am Muslim, I cannot wear a swimsuit": Muslim girls negotiate participation opportunities for physical activity.

    PubMed

    Hamzeh, Manal; Oliver, Kimberly L

    2012-06-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 muslim girls (ages 14- 17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self mapping questionnaires, digital photos, private journal entries, and recordings of informal conversations. We discuss (a) how three discursive challenges emerged in veiling-off opportunities for physical activity, and (b) how the girls uncovered alternative ways of being physically active. To promote active life practices with muslim girls, we need to (a) navigate the diversity of young muslims within the intersecting discourses in their lives that potentially challenge their participation in physical activities, and (b) honor young muslims' choices while negotiating their chances of maintaining physical activities.

  11. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... curriculum. (f) Providing special programs or tutoring in science, technology, engineering, or mathematics...-risk children in obtaining summer jobs. (4) Academic counseling. (5) Financial and economic literacy... engagement and leadership activities. (n) Disseminating information that promotes the importance of...

  12. 34 CFR 694.22 - What other activities may all GEAR UP projects provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... curriculum. (f) Providing special programs or tutoring in science, technology, engineering, or mathematics...-risk children in obtaining summer jobs. (4) Academic counseling. (5) Financial and economic literacy... engagement and leadership activities. (n) Disseminating information that promotes the importance of...

  13. Providing Education to Child Care Instructors: Matching Children's Learning Activities to Cognitive Development.

    ERIC Educational Resources Information Center

    Desjardins, Margaret M.

    Child care instructors and their aides at the Good Shepherd Day Care Center, Punta Gorda, Florida, were taught skills needed to develop classroom activities matching the cognitive development of 3- and 4-year-old children. Through a program of in-service activity in child growth and development, instruction was provided to enable teachers to more…

  14. School Sports Opportunities Influence Physical Activity in Secondary School and beyond

    ERIC Educational Resources Information Center

    Fuller, Daniel; Sabiston, Catherine; Karp, Igor; Barnett, Tracie; O'Loughlin, Jennifer

    2011-01-01

    Background: The purpose of the present study was to examine whether the availability of intramural or extramural sports in secondary schools is associated with physical activity levels in youth throughout secondary school and at age 20. Methods: Eight hundred and eight adolescents from 10 secondary schools in Montreal, Canada, provided physical…

  15. Disposal R&D in the Used Fuel Disposition Campaign: A Discussion of Opportunities for Active International Collaboration

    SciTech Connect

    Birkholzer, J.T.

    2011-06-01

    For DOE's Used Fuel Disposition Campaign (UFDC), international collaboration is a beneficial and cost-effective strategy for advancing disposal science with regards to multiple disposal options and different geologic environments. While the United States disposal program focused solely on Yucca Mountain tuff as host rock over the past decades, several international programs have made significant progress in the characterization and performance evaluation of other geologic repository options, most of which are very different from the Yucca Mountain site in design and host rock characteristics. Because Yucca Mountain was so unique (e.g., no backfill, unsaturated densely fractured tuff), areas of direct collaboration with international disposal programs were quite limited during that time. The decision by the U.S. Department of Energy to no longer pursue the disposal of high-level radioactive waste and spent fuel at Yucca Mountain has shifted UFDC's interest to disposal options and geologic environments similar to those being investigated by disposal programs in other nations. Much can be gained by close collaboration with these programs, including access to valuable experience and data collected over recent decades. Such collaboration can help to efficiently achieve UFDC's long-term goals of conducting 'experiments to fill data needs and confirm advanced modeling approaches' (by 2015) and of having a 'robust modeling and experimental basis for evaluation of multiple disposal system options' (by 2020). This report discusses selected opportunities of active international collaboration, with focus on both Natural Barrier System (NBS) and Engineered Barrier System (EBS) aspects and those opportunities that provide access to field data (and respective interpretation/modeling) or allow participation in ongoing field experiments. This discussion serves as a basis for the DOE/NE-53 and UFDC planning process for FY12 and beyond.

  16. Promoting physical activity among children and youth in disadvantaged South Australian CALD communities through alternative community sport opportunities.

    PubMed

    Rosso, Edoardo; McGrath, Richard

    2016-02-29

    Issue addressed: Recently arrived migrants and refugees from a culturally and linguistically diverse background (CALD) may be particularly vulnerable to social exclusion. Participation in sport is endorsed as a vehicle to ease the resettlement process; however, in Australia, this is often thought as a simple matter of integration into existing sport structures (e.g. clubs). This approach fails to place actual community needs at the centre of sport engagement efforts.Methods: A consultation framework was established with South Australian CALD community leaders and organisations to scope needs for community-based alternatives to participation in traditional sport (e.g. clubs), co-design a suitable community sport program and pilot it in five communities. Interviews and questionnaire surveys were conducted with participants, community representatives, stakeholders and volunteers.Results: Regular, free soccer activities engaged 263 young people from a great variety of nationalities, including over 50% refugees, in secondary state school and community-based sites.Conclusion: Alternative community sport programs can provide a basic but valuable forum to promote physical activity and associated well being in CALD and refugee communities.So what?: Alternative approaches can extend the health benefits of sport participation to disadvantaged children and youth who are excluded from traditional sport participation opportunities.

  17. "Because I Am Muslim, I Cannot Wear a Swimsuit:" Muslim Girls Negotiate Participation Opportunities for Physical Activity

    ERIC Educational Resources Information Center

    Hamzeh, Manal; Oliver, Kimberly L.

    2012-01-01

    Drawing on the works of postcolonial critical feminist and Arab Muslim feminist scholars, we discuss in this paper how 4 Muslim girls (ages 14-17 years) negotiated their participation in opportunities for physical activity. Data collection methods included self-mapping questionnaires, digital photos, private journal entries, and recordings of…

  18. 75 FR 2546 - Opportunity for Co-Sponsorship of the President's Challenge Physical Activity and Fitness Awards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... HUMAN SERVICES Opportunity for Co-Sponsorship of the President's Challenge Physical Activity and Fitness Awards Program; Correction AGENCY: President's Council on Physical Fitness and Sports. ACTION: Notice; correction. SUMMARY: The President's Council on Physical Fitness and Sports published a document in...

  19. ARDUSAT, an Arduino-Based CubeSat Providing Students with the Opportunity to Create their own Satellite Experiment and Collect Real-World Space Data

    NASA Astrophysics Data System (ADS)

    Geeroms, D.; Bertho, S.; De Roeve, M.; Lempens, R.; Ordies, M.; Prooth, J.

    2015-09-01

    Short for “Arduino Satellite”, ArduSat is an open-source Nanosatellite, based on the CubeSat standard. The extensive Arduino sensor suite on board gives students the opportunity to create their own satellite experiments and collect real-world space data using the Arduino open-source prototyping platform. From March until May 2014, two undergraduate physics students from Hasselt University used the downloadable ArduSat Software Development Kit which allowed them to design the command sequences they used to conduct their experiments.

  20. The Age of Enlightenment: Evolving Opportunities in Brain Research Through Optical Manipulation of Neuronal Activity

    PubMed Central

    Jerome, Jason; Heck, Detlef H.

    2011-01-01

    Optical manipulation of neuronal activity has rapidly developed into the most powerful and widely used approach to study mechanisms related to neuronal connectivity over a range of scales. Since the early use of single site uncaging to map network connectivity, rapid technological development of light modulation techniques has added important new options, such as fast scanning photostimulation, massively parallel control of light stimuli, holographic uncaging, and two-photon stimulation techniques. Exciting new developments in optogenetics complement neurotransmitter uncaging techniques by providing cell-type specificity and in vivo usability, providing optical access to the neural substrates of behavior. Here we review the rapid evolution of methods for the optical manipulation of neuronal activity, emphasizing crucial recent developments. PMID:22275886

  1. The age of enlightenment: evolving opportunities in brain research through optical manipulation of neuronal activity.

    PubMed

    Jerome, Jason; Heck, Detlef H

    2011-01-01

    Optical manipulation of neuronal activity has rapidly developed into the most powerful and widely used approach to study mechanisms related to neuronal connectivity over a range of scales. Since the early use of single site uncaging to map network connectivity, rapid technological development of light modulation techniques has added important new options, such as fast scanning photostimulation, massively parallel control of light stimuli, holographic uncaging, and two-photon stimulation techniques. Exciting new developments in optogenetics complement neurotransmitter uncaging techniques by providing cell-type specificity and in vivo usability, providing optical access to the neural substrates of behavior. Here we review the rapid evolution of methods for the optical manipulation of neuronal activity, emphasizing crucial recent developments.

  2. 34 CFR 647.4 - What activities and services may a project provide?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... programs. (g) Mentoring programs involving faculty members or students at institutions of higher education... 34 Education 3 2010-07-01 2010-07-01 false What activities and services may a project provide? 647.4 Section 647.4 Education Regulations of the Offices of the Department of Education...

  3. Insurance Receipt and Readiness for Opportunities under the Affordable Care Act: A National Survey of Treatment Providers for Substance Use Disorders.

    PubMed

    Aletraris, Lydia; Edmond, Mary Bond; Roman, Paul M

    2017-04-13

    This study measures the readiness of substance use disorder (SUD) treatment to use opportunities under the Affordable Care Act by examining Medicaid and private insurance acceptance between 2011 and 2013, as well as center characteristics associated with acceptance. Data for this study were from a random sample of SUD treatment centers in the United States. Interviews were conducted on site and face to face, with administrative and clinical directors. We employed logistic regression analyses to examine Medicaid acceptance and private insurance acceptance. We found that 59% of centers accepted Medicaid and 55% accepted private insurance. Accredited centers were more likely to accept Medicaid. A 12-step orientation and greater reliance on female clients were negatively associated with Medicaid acceptance. Larger centers and centers with a greater percentage of counselors with advanced degrees had greater odds of accepting private insurance. Centers that offered residential treatment had lower odds of accepting either Medicaid or private insurance. For private insurance acceptance, having a specific track for homeless patients lowered the odds of acceptance, as did having a greater percentage of Hispanic clients. Newly insured individuals under the ACA may have difficulty finding a program that accepts insurance. Future research should examine effects of Medicaid expansion on SUD treatment delivery.

  4. Feasibility of providing computer activities for nursing home residents with dementia

    PubMed Central

    Beck, Cornelia; Hong, Song Hee

    2014-01-01

    Introduction Nursing home residents with dementia need cognitively stimulating and enjoyable activities, and computer technology offers them a means of engaging in such activities. This study therefore examined the feasibility of providing a 12-week computer activity program (CAP) for nursing homes residents with dementia. Methods Fourteen participants completed the CAP, and 462 observational logs of CAP sessions were analyzed. Results On average, participants completed 33 sessions amounting to 936.5 minutes over 12 weeks. Participants with mild and moderate dementia preferred playing a cognitively challenging game such as solitaire, while those with severe dementia enjoyed watching slideshows with music. Conclusion The findings suggest that it is important to match computer activities to interests and cognitive ability in order to increase participation and satisfaction of NH residents with dementia. PMID:25343006

  5. Assessing Challenges and Opportunities for Education and Communication Activities for International Polar Year 2007-2008

    NASA Astrophysics Data System (ADS)

    McCaffrey, M. S.

    2005-05-01

    Considerable planning has gone into identifying ways to maximize International Polar Year 2007-2008 (IPY) as a global event that will facilitate the integration of research and education inherent in IPY, and draw the interest and involvement of people around the world. Documents developed through the IPY planning process, including NRC Reports (2004), and drafts reports on education and outreach from the ICSU IPY Planning Group in the Fall of 2004, and the Bridging the Poles workshop of June, 2004, articulate the tremendous potential for IPY beyond the formal research agenda and goals. With less that two years before the start of IPY and fewer than fours years before the activities are completed, these and emerging opportunities face a number of challenges. In addition to the limited time frame remaining to prepare for these activities, participants involved with IPY education and outreach will also need to consider factors such as: uncertain funding for such activities; the lack of established international networks for geoscience education; the need for high level coordination of IPY education and communication; and the creative and intellectual challenge of making the polar regions relevant to people around the world. The planning process has identified six constituencies as key audiences of IPY communication efforts: i) the scientific/research community, ii) young and potentially new polar researchers, iii) the pre-university education community, iv) arctic communities, iv) the general public, and v) decision-makers. Understanding and meeting these audiences' expectations through on-going evaluation and engagement will be key to successful IPY education and outreach efforts. A number of distinct education and outreach projects have been proposed to the ICSU-WMO IPY planning process, such as courses and workshops on specific aspects of IPY, including efforts to address the social and cultural dimension of Arctic peoples. To help meet the challenges, achieve the

  6. 78 FR 76851 - Agency Information Collection Activities: Haitian Hemispheric Opportunity Through Partnership...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...As part of its continuing effort to reduce paperwork and respondent burden, CBP invites the general public and other Federal agencies to comment on an information collection requirement concerning the Haitian Hemispheric Opportunity through Partnership Encouragement Act of 2006 (``Haiti HOPE Act''). This request for comment is being made pursuant to the Paperwork Reduction Act of 1995 (Pub. L.......

  7. European School of Internal Medicine: a window of opportunity for RCP activities in Europe.

    PubMed

    Davidson, Chris; Higgens, Clare

    2009-04-01

    The Royal College of Physicians (RCP) is to host the European School of Internal Medicine for two years from 2009-10. This affords a unique opportunity for specialist registrars to exchange ideas about professional development and training and to make contacts with young internists from across Europe. Such links should prove useful for future RCP initiatives in European medicine.

  8. A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation

    PubMed Central

    Singla, Nikhil; Erdjument-Bromage, Hediye; Himanen, Juha P.; Muir, Tom W.; Nikolov, Dimitar B.

    2011-01-01

    SUMMARY We have developed a methodology for generating milligram amounts of functional Eph tyrosine kinase receptor using the protein engineering approach of expressed protein ligation. Stimulation with ligand induces efficient autophosphorylation of the semisynthetic Eph construct. The in vitro phosphorylation of key Eph tyrosine residues upon ligand-induced activation was monitored via time-resolved, quantitative phosphoproteomics, suggesting a precise and unique order of phosphorylation of the Eph tyrosines in the kinase activation process. To our knowledge, this work represents the first reported semisynthesis of a receptor tyrosine kinase and provides a potentially general method for producing single-pass membrane proteins for structural and biochemical characterization. PMID:21439481

  9. Peer Coaching: Principals Learning from Principals. Pairing Novice and Experienced Principals Provides Both with Opportunities To Promote Reflective Thinking In Their Decision-Making

    ERIC Educational Resources Information Center

    Rich, Robert A.; Jackson, Sherion H.

    2005-01-01

    Unlike mentoring relationships, peer coaching is a voluntary partnership that uses reflections of past experiences to influence decision-making. The authors provide a step-by-step guide for establishing and maintaining peer-coaching partnerships.

  10. Hydrogen Infrastructure Market Readiness: Opportunities and Potential for Near-term Cost Reductions; Proceedings of the Hydrogen Infrastructure Market Readiness Workshop and Summary of Feedback Provided through the Hydrogen Station Cost Calculator

    SciTech Connect

    Melaina, M. W.; Steward, D.; Penev, M.; McQueen, S.; Jaffe, S.; Talon, C.

    2012-08-01

    Recent progress with fuel cell electric vehicles (FCEVs) has focused attention on hydrogen infrastructure as a critical commercialization barrier. With major automakers focused on 2015 as a target timeframe for global FCEV commercialization, the window of opportunity is short for establishing a sufficient network of hydrogen stations to support large-volume vehicle deployments. This report describes expert feedback on the market readiness of hydrogen infrastructure technology from two activities.

  11. Opportunities to exploit non-neutralizing HIV-specific antibody activity

    PubMed Central

    Ackerman, Margaret E.; Alter, Galit

    2016-01-01

    Antibodies act as a nexus between innate and adaptive immunity: they provide a means to engage a spectrum of innate immune effector cells in order to clear viral particles and infected cells, and prime antigen presentation. This functional landscape is remarkably complex, and depends on antibody isotype, subclass, and glycosylation; the expression levels and patterns of a suite of Fc receptors with both complementary and opposing activities; and a host of innate immune cells capable of differential responses to opsonized particles and present at different sites. In vivo, even neutralizing antibodies rely on their ability to act as molecular beacons and recruit innate immune effector cells in order to provide protection, and results from both human and macaque studies have implicated these effector functions in vaccine-mediated protection. Thus, while enhancing effector function is a tractable handle for potentiating antibody-mediated protection from HIV infection, success will depend critically on leveraging understanding of the means by which antibodies with specific functional profiles could be elicited, which effector functions could provide optimal protection, and perhaps most critically, how to efficiently recruit the innate effector cells present at sites of infection. PMID:24191934

  12. Kinetics of nucleotide entry into RNA polymerase active site provides mechanism for efficiency and fidelity.

    PubMed

    Wang, Beibei; Sexton, Rachel E; Feig, Michael

    2017-04-01

    During transcription, RNA polymerase II elongates RNA by adding nucleotide triphosphates (NTPs) complementary to a DNA template. Structural studies have suggested that NTPs enter and exit the active site via the narrow secondary pore but details have remained unclear. A kinetic model is presented that integrates molecular dynamics simulations with experimental data. Previous simulations of trigger loop dynamics and the dynamics of matched and mismatched NTPs in and near the active site were combined with new simulations describing NTP exit from the active site via the secondary pore. Markov state analysis was applied to identify major states and estimate kinetic rates for transitions between those states. The kinetic model predicts elongation and misincorporation rates in close agreement with experiment and provides mechanistic hypotheses for how NTP entry and exit via the secondary pore is feasible and a key feature for achieving high elongation and low misincorporation rates during RNA elongation.

  13. The Active Site of Oligogalacturonate Lyase Provides Unique Insights into Cytoplasmic Oligogalacturonate β-Elimination*

    PubMed Central

    Abbott, D. Wade; Gilbert, Harry J.; Boraston, Alisdair B.

    2010-01-01

    Oligogalacturonate lyases (OGLs; now also classified as pectate lyase family 22) are cytoplasmic enzymes found in pectinolytic members of Enterobacteriaceae, such as the enteropathogen Yersinia enterocolitica. OGLs utilize a β-elimination mechanism to preferentially catalyze the conversion of saturated and unsaturated digalacturonate into monogalacturonate and the 4,5-unsaturated monogalacturonate-like molecule, 5-keto-4-deoxyuronate. To provide mechanistic insights into the specificity of this enzyme activity, we have characterized the OGL from Y. enterocolitica, YeOGL, on oligogalacturonides and determined its three-dimensional x-ray structure to 1.65 Å. The model contains a Mn2+ atom in the active site, which is coordinated by three histidines, one glutamine, and an acetate ion. The acetate mimics the binding of the uronate group of galactourono-configured substrates. These findings, in combination with enzyme kinetics and metal supplementation assays, provide a framework for modeling the active site architecture of OGL. This enzyme appears to contain a histidine for the abstraction of the α-proton in the −1 subsite, a residue that is highly conserved throughout the OGL family and represents a unique catalytic base among pectic active lyases. In addition, we present a hypothesis for an emerging relationship observed between the cellular distribution of pectate lyase folding and the distinct metal coordination chemistries of pectate lyases. PMID:20851883

  14. Long-term care and health information technology: opportunities and responsibilities for long-term and post-acute care providers.

    PubMed

    MacTaggart, Patricia; Thorpe, Jane Hyatt

    2013-01-01

    Long-term and post-acute care providers (LTPAC) need to understand the multiple aspects of health information technology (HIT) in the context of health systems transformation in order to be a viable participant. The issues with moving to HIT are not just technical and funding, but include legal and policy, technical and business operations, and very significantly, governance. There are many unanswered questions. However, changes in payment methodologies, service delivery models, consumer expectations, and regulatory requirements necessitate that LTPAC providers begin their journey.

  15. A wide range of activity duration cutoffs provided unbiased estimates of exposure to computer use.

    PubMed

    Chang, Che-Hsu; Johnson, Peter W; Dennerlein, Jack T

    2008-12-01

    Integrative computer usage monitors have become widely used in epidemiologic studies to investigate the exposure-response relationship of computer-related musculoskeletal disorders. These software programs typically estimate the exposure duration of computer use by summing precisely recorded durations of input device activities and durations of inactivity periods shorter than a predetermined activity duration cutoff value, usually 30 or 60 sec. The goal of this study was to systematically compare the validity of a wide range of cutoff values. Computer use activity of 20 office workers was observed for 4 consecutive hours using both a video camera and a usage monitor. Video recordings from the camera were analyzed using specific observational criteria to determine computer use duration. This observed duration then served as the reference and was compared with 238 estimates of computer use duration calculated from the usage monitor data using activity duration cutoffs ranging from 3 to 240 sec in 1-sec increments. Estimates calculated with cutoffs ranging from 28 to 60 sec were highly correlated with the observed duration (Spearman's correlation 0.87 to 0.92) and had nearly ideal linear relationships with the observed duration (slopes and r-squares close to one, and intercepts close to zero). For the same range of cutoff values, when the observed and estimated durations were compared for dichotomous exposure classification across participants, minimal exposure misclassification was observed. It is concluded that activity duration cutoffs ranging from 28 to 60 sec provided unbiased estimates of computer use duration.

  16. Antibody therapies for melanoma: New and emerging opportunities to activate immunity (Review)

    PubMed Central

    MALAS, SADEK; HARRASSER, MICAELA; LACY, KATIE E.; KARAGIANNIS, SOPHIA N.

    2014-01-01

    The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we discuss different antibody immunotherapy approaches evaluated in the context of melanoma, each designed to act on distinct targets and to employ different mechanisms to restrict tumour growth and spread. Monoclonal antibodies recognising melanoma-associated antigens such as CSPG4/MCSP and targeting elements of tumour-associated vasculature (VEGF) have constituted long-standing translational approaches aimed at reducing melanoma growth and metastasis. Recent insights into mechanisms of immune regulation and tumour-immune cell interactions have helped to identify checkpoint molecules on immune (CTLA4, PD-1) and tumour (PD-L1) cells as promising therapeutic targets. Checkpoint blockade with antibodies to activate immune responses and perhaps to counteract melanoma-associated immunomodulatory mechanisms led to the first clinical breakthrough in the form of an anti-CTLA4 monoclonal antibody. Novel modalities to target key mechanisms of immune suppression and to redirect potent effector cell subsets against tumours are expected to improve clinical outcomes and to provide previously unexplored avenues for therapeutic interventions. PMID:24969320

  17. Antibody therapies for melanoma: new and emerging opportunities to activate immunity (Review).

    PubMed

    Malas, Sadek; Harrasser, Micaela; Lacy, Katie E; Karagiannis, Sophia N

    2014-09-01

    The interface between malignant melanoma and patient immunity has long been recognised and efforts to treat this most lethal form of skin cancer by activating immune responses with cytokine, vaccine and also antibody immunotherapies have demonstrated promise in limited subsets of patients. In the present study, we discuss different antibody immunotherapy approaches evaluated in the context of melanoma, each designed to act on distinct targets and to employ different mechanisms to restrict tumour growth and spread. Monoclonal antibodies recognising melanoma-associated antigens such as CSPG4/MCSP and targeting elements of tumour-associated vasculature (VEGF) have constituted long-standing translational approaches aimed at reducing melanoma growth and metastasis. Recent insights into mechanisms of immune regulation and tumour-immune cell interactions have helped to identify checkpoint molecules on immune (CTLA4, PD-1) and tumour (PD-L1) cells as promising therapeutic targets. Checkpoint blockade with antibodies to activate immune responses and perhaps to counteract melanoma-associated immunomodulatory mechanisms led to the first clinical breakthrough in the form of an anti-CTLA4 monoclonal antibody. Novel modalities to target key mechanisms of immune suppression and to redirect potent effector cell subsets against tumours are expected to improve clinical outcomes and to provide previously unexplored avenues for therapeutic interventions.

  18. Equal-opportunity burden. Legal order for Florida hospital could mean new hiring rules on top of health reform hurdles for thousands of healthcare providers.

    PubMed

    Carlson, Joe

    2010-12-06

    A judge's decision that a Florida hospital is a federal subcontractor because it provides care through the military's Tricare program has put the industry on alert. Hospitals fear they'll be forced to to jump through lots of hoops to comply with federal rules regarding hiring. "Many of the substantive obligations that are sought to be imposed ... are already fully applicable to hospitals through state and other federal laws," says Curt Kirschner, left, a lawyer with Jones Day.

  19. Patient–Provider Communication: Understanding the Role of Patient Activation for Latinos in Mental Health Treatment

    PubMed Central

    Cortes, Dharma E.; Mulvaney-Day, Norah; Fortuna, Lisa; Reinfeld, Sarah; Alegría, Margarita

    2012-01-01

    This article highlights results from the Right Question Project–Mental Health (RQP-MH), an intervention designed to teach skills in question formulation and to increase patients’ participation in decisions about mental health treatment. Of participants in the RQP-MH intervention, 83% were from a Latino background, and 75% of the interviews were conducted in Spanish. The authors present the steps participants undertook in the process of becoming “activated” to formulate effective questions and develop decision-making skills in relation to their care. Findings suggest that patient activation and empowerment are interdependent because many of the skills (i.e., question formulation, direct patient–provider communication) required to become an “activated patient” are essential to achieve empowerment. Also, findings suggest that cultural and contextual factors can influence the experience of Latinos regarding participation in health care interactions. The authors provide recommendations for continued research on the patient activation process and further application of this strategy in the mental health field, especially with Latinos. PMID:18413668

  20. The photochemical reflectance index provides an optical indicator of spring photosynthetic activation in evergreen conifers.

    PubMed

    Wong, Christopher Y S; Gamon, John A

    2015-04-01

    In evergreens, the seasonal down-regulation and reactivation of photosynthesis is largely invisible and difficult to assess with remote sensing. This invisible phenology may be changing as a result of climate change. To better understand the mechanism and timing of these hidden physiological transitions, we explored several assays and optical indicators of spring photosynthetic activation in conifers exposed to a boreal climate. The photochemical reflectance index (PRI), chlorophyll fluorescence, and leaf pigments for evergreen conifer seedlings were monitored over 1 yr of a boreal climate with the addition of gas exchange during the spring. PRI, electron transport rate, pigment levels, light-use efficiency and photosynthesis all exhibited striking seasonal changes, with varying kinetics and strengths of correlation, which were used to evaluate the mechanisms and timing of spring activation. PRI and pigment pools were closely timed with photosynthetic reactivation measured by gas exchange. The PRI provided a clear optical indicator of spring photosynthetic activation that was detectable at leaf and stand scales in conifers. We propose that PRI might provide a useful metric of effective growing season length amenable to remote sensing and could improve remote-sensing-driven models of carbon uptake in evergreen ecosystems.

  1. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans.

    PubMed

    Evans, Erica K; Tester, Richland; Aslanian, Sharon; Karp, Russell; Sheets, Michael; Labenski, Matthew T; Witowski, Steven R; Lounsbury, Heather; Chaturvedi, Prasoon; Mazdiyasni, Hormoz; Zhu, Zhendong; Nacht, Mariana; Freed, Martin I; Petter, Russell C; Dubrovskiy, Alex; Singh, Juswinder; Westlin, William F

    2013-08-01

    Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as promising agents in autoimmune disease and B cell malignancies. Bruton's tyrosine kinase (Btk) plays a crucial role in B cell development and activation through the BCR signaling pathway and represents a new target for diseases characterized by inappropriate B cell activity. N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide (CC-292) is a highly selective, covalent Btk inhibitor and a sensitive and quantitative assay that measures CC-292-Btk engagement has been developed. This translational pharmacodynamic assay has accompanied CC-292 through each step of drug discovery and development. These studies demonstrate the quantity of Btk bound by CC-292 correlates with the efficacy of CC-292 in vitro and in the collagen-induced arthritis model of autoimmune disease. Recently, CC-292 has entered human clinical trials with a trial design that has provided rapid insight into safety, pharmacokinetics, and pharmacodynamics. This first-in-human healthy volunteer trial has demonstrated that a single oral dose of 2 mg/kg CC-292 consistently engaged all circulating Btk protein and provides the basis for rational dose selection in future clinical trials. This targeted covalent drug design approach has enabled the discovery and early clinical development of CC-292 and has provided support for Btk as a valuable drug target for B-cell mediated disorders.

  2. Dynamic Response of the Environment at the Moon (DREAM): Providing Opportunities for Students and Teachers to Learn About the Solar-lunar Environmental Connection

    NASA Astrophysics Data System (ADS)

    Bleacher, L.; Weir, H. M.; Twu, Y.; Farrell, W. M.; Gross, N. A.

    2009-12-01

    The Dynamic Response of the Environment at the Moon (DREAM) team is one of seven teams comprising the NASA Lunar Science Institute. DREAM’s goal is to reveal, advance, and test the extremes of the solar-lunar environmental connection. DREAM’s education and outreach (E/PO) program is focused on student and teacher participation with scientists. The primary component of the DREAM E/PO program is two Lunar Extreme Workshops (LEWs) and the supporting materials developed for each LEW. The workshops will bring together scientists and modelers from the DREAM team with advanced high school and/or community college students and their teachers. The LEWs will allow student/teacher participants to interact directly with the scientists and to experience the process of science in action. Participation in LEWs and pre-LEW training will expose students to science, technology, engineering, and math (STEM) careers and engage them in learning new STEM content. During the two LEWs, the new, integrated lunar models developed by the DREAM team will be tested using extreme environmental drivers. These extreme events include: 1) solar storms and human excursion into Shackleton Crater and 2) human activity/lunar excavation and impact cratering. Although the LEWs will be complex in nature, the students and teachers will receive extensive pre-LEW training via access to online curricular resources already in development and Webinars with DREAM science team members, during which the students/teachers will get to know the team members and put their new knowledge into context. The curricular materials will include resources and activities pertaining to space weather, plasma, electricity, circuits, magnetism, magnetospheres, exospheres, impact cratering, and modeling. The activities are being mapped to the National Science Education Standards and the American Association for the Advancement of Science’s Benchmarks for Science Literacy. Students will be encouraged to read and review

  3. Activities and perceptions of pharmacists providing tobacco control services in community pharmacy in Thailand.

    PubMed

    Thananithisak, Chuanchom; Nimpitakpong, Piyarat; Chaiyakunapruk, Nathorn

    2008-05-01

    Community pharmacists' involvement in tobacco control and their perceived role and barriers were assessed. In part I, a self-administered questionnaire was mailed to 164 community pharmacists who applied for community pharmacy accreditation from the Thai Pharmacy Council in 2003. In part II, an in-depth interview was conducted among 13 community pharmacists who participated in the 1-day smoking cessation services training. Main outcome measures were tobacco control-related activities, perceived tobacco control role, and perceived barriers. The questionnaire response rate was 51% (83/164 pharmacists), with half of the respondents (42/83, 51%) reporting active tobacco control activities. Of these pharmacists, seven (7/42, 17%) reported participating in public or policy advocacy by campaigning against smoking in the community. Thirty-four (34/42, 81%) and thirty-six (36/42, 86%) reported engaging in activities in their own pharmacies by providing educational materials and smoking cessation services, respectively. Even though the perceived roles in tobacco control of these pharmacists were high, they also reported several barriers, especially in five categories: lack of client demand, lack of educational materials, lack of smoking cessation products, lack of knowledge and skill, and lack of follow-up visits. On the other hand, lack of time and lack of reimbursement were not indicated as important barriers. Data from in-depth interviews confirmed these findings. This study revealed that Thai community pharmacists were engaged in various levels of tobacco control-related activities. Most of them perceived the significance of tobacco control activities. However, several barriers were also reported and need to be addressed further.

  4. Biomedical health assessments of the Florida manatee in Crystal River - providing opportunities for training during the capture, handling, and processing of this endangered aquatic mammal

    USGS Publications Warehouse

    Bonde, Robert K.; Garrett, Andrew; Belanger, Michael; Askin, Nesime; Tan, Luke; Wittnich, Carin

    2012-01-01

    Federal and state researchers have been involved in manatee (Trichechus manatus) biomedical health assessment programs for a couple of decades. These benchmark studies have provided a foundation for the development of consistent capture, handling, and processing techniques and protocols. Biologists have implemented training and encouraged multi-agency participation whenever possible to ensure reliable data acquisition, recording, sample collection, publication integrity, and meeting rigorous archival standards. Under a U.S. Fish and Wildlife Service wildlife research permit granted to the U.S. Geological Survey (USGS) Sirenia Project, federal biologists and collaborators are allowed to conduct research studies on wild and captive manatees detailing various aspects of their biology. Therefore, researchers with the project have been collaborating on numerous studies over the last several years. One extensive study, initiated in 2006 has focused on health and fitness of the winter manatee population located in Crystal River, Florida. During those health assessments, capture, handling, and work-up training has been afforded to many of the participants. That study has successfully captured and handled 123 manatees. The data gathered have provided baseline information on manatee health, reproductive status, and nutritional condition. This research initiative addresses concerns and priorities outlined in the Florida Manatee Recovery Plan. The assessment teams strive to continue this collaborative effort to help advance our understanding of health-related issues confronting manatees throughout their range and interlacing these findings with surrogate species concepts.

  5. Technology solutions to support supervisory activities and also to provide information access to the society

    NASA Astrophysics Data System (ADS)

    Paladini, D.; Mello, A. B.

    2016-07-01

    Inmetro's data about the conformity of certificated products, process and services are, usually, displayed at fragmented databases of difficult access for several reasons, for instance, the lack of computational solutions which allow this kind of access to its users. A discussion about some of the technological solutions to support supervisory activities by the appropriate regulatory bodies and also to provide information access to society in general is herein presented, along with a theoretical explanation of the pros and cons of such technologies to the conclusion that a mobile platform seems to be the best tool for the requirements of Inmetro.

  6. Emergency department syndromic surveillance providing early warning of seasonal respiratory activity in England.

    PubMed

    Hughes, H E; Morbey, R; Hughes, T C; Locker, T E; Pebody, R; Green, H K; Ellis, J; Smith, G E; Elliot, A J

    2016-04-01

    Seasonal respiratory infections place an increased burden on health services annually. We used a sentinel emergency department syndromic surveillance system to understand the factors driving respiratory attendances at emergency departments (EDs) in England. Trends in different respiratory indicators were observed to peak at different points during winter, with further variation observed in the distribution of attendances by age. Multiple linear regression analysis revealed acute respiratory infection and bronchitis/bronchiolitis ED attendances in patients aged 1-4 years were particularly sensitive indicators for increasing respiratory syncytial virus activity. Using near real-time surveillance of respiratory ED attendances may provide early warning of increased winter pressures in EDs, particularly driven by seasonal pathogens. This surveillance may provide additional intelligence about different categories of attendance, highlighting pressures in particular age groups, thereby aiding planning and preparation to respond to acute changes in EDs, and thus the health service in general.

  7. Providing sporting experiences for children in Out of School Hours Care (OSHC) environments: sport and physical activity participation and intentions.

    PubMed

    Spittle, Michael; O'Meara, James; Garnham, Jennie; Kerr, Megan

    2008-06-01

    The Out of School Hours Sports Program (OSHSP) aimed to provide structured sporting experiences and community links to local clubs for children in Out of School Hours Care (OSHC). The OSHSP involved 17 State Sporting Associations (SSAs), 71 OSHC Services and local club representatives. This study explored children's participation in sport in and outside the OSHSP and parental intention for participation in sport in and outside the OSHSP. Surveys were received from 211 children (76 girls and 125 boys; mean age=7.9 years, S.D.=1.7) and their parents/guardians (37.9% response rate). OSHC is characterised by freedom of choice of participation in activities by children. The OSHSP was used to provide an opportunity to choose to participate in a sport while attending OSHC. At the OSHC Services surveyed, between 7.1 and 100% of the children attending OSHC chose to participate in the OSHSP. Of those children who chose to participate, 85% were participating in a sport, usually a different sport to the one offered in the OSHSP. This participation was largely club-based (49.8%), most often once a week for training and competition (55.2%). Parental intentions for children's participation in the OSHSP sports varied with respect to the number of years attending the OSHSP, where children played and trained in their main sport, and how many times a week a child played and trained in their main sport. Older children tended to play and train for sport more times per week and had been attending the OSHC for more years than younger children.

  8. Time-resolved FTIR studies provide activation free energy, activation enthalpy and activation entropy for GTPase reactions

    NASA Astrophysics Data System (ADS)

    Kötting, Carsten; Gerwert, Klaus

    2004-12-01

    GTPases, which catalyze the hydrolysis of GTP to GDP and P i, play a key role in the regulation of many biological processes. In this work, we quantify the activation parameters ΔG0∗,ΔH0∗andΔS0∗ for the hydrolysis reaction of GTP in water, in water with Mg 2+ ions and in Ras. Ras belongs to the superfamily of small GTPases (guanine nucleotide-binding proteins; GNBPs). Surprisingly, we find that in all cases, the activation energy consists mainly of enthalpic contributions. Additionally, the small entropic contributions in water and in Ras are similar, so that ΔΔ S* is close to 0. Thus the entropic contributions are only minor in GTPase catalysis and the enthalpic contributions from electrostatic interactions are key to the catalysis. The protein induced change in charge distribution of GTP can be monitored by time-resolved difference FTIR spectroscopy. For Ras the main effect due to protein binding is a charge shift towards the β-phosphate of GTP. This seems to have the main contribution to the catalytic mechanism. Because the G-domain of Ras is highly conserved in GNBPs, we propose that the finding here holds for all GNBPs.

  9. Providing farmers, ranchers, and foresters in California with actionable climate information: opportunities and obstacles for California's USDA Regional Climate Sub Hub

    NASA Astrophysics Data System (ADS)

    Kerr, A. C.; Steenwerth, K. L.; Stine, P.; Chambers, J.; Fischer, C.; Kiger, L.; Hedt, T.; Gonzales, O.; Tse, R.; Tse, A.; Gunasekara, A.; Henly, R.; DeLaRosa, J.; Battany, M.; Pathak, T.; Parker, D.; Schwartz, M.; Tjeerdema, R.; Kalansky, J.; Kehmeier, E.; Xides, A.; Marshall, A.; Jagannathan, K.

    2015-12-01

    California is the #1 agricultural state in the US, with output worth $50 billion in 2014. California produces half the nation's specialty crops (fruits, vegetables, and nuts) and is a leader in beef and dairy production. California also has 10% of the forestland west of the Mississippi, including many economically and ecologically important forest types. The USDA Regional Climate Sub Hub for California was created in 2014 to help land users (farmers, ranchers, and forest land owners) cope with climate variability and change, via two-way linkages with producers of climate information. In its first year and a half, the Sub Hub has formed partnerships with California's many other climate-focused organizations, including state and federal government, universities, and NGOs. The Sub Hub coordinates climate-related work among several USDA agencies (ARS, FS, NRCS, and others), which formerly had no mechanism to do so. The Sub Hub also works with other federal climate programs (such as the DOI's CA Landscape Conservation Cooperative, with which the Sub Hub is engaged in a multi-year assessment to balance conservation and agriculture in the Central Valley). State government agencies, such as the Natural Resources Agency and the Department of Food and Agriculture, are key partners for priority-setting and data-sharing. One of the Sub Hub's crucial synergies is with UC Cooperative Extension, which provides insight into land users' needs and provides an outlet to deliver Sub Hub products on the ground. In response to stakeholder concerns, the Sub Hub's 2015-16 emphasis is the ongoing California drought. The Sub Hub's current stakeholder-focused projects include (1) a climate vulnerability assessment of California rangelands, including detailed maps of likely vegetation change and suggestions for location-specific adaptation options; (2) a comprehensive climate-related update of Cooperative Extension's widely used Forest Stewardship Series for private landowners; (3) a study on

  10. Active Referral: An Innovative Approach to Engaging Traditional Healthcare Providers in TB Control in Burkina Faso

    PubMed Central

    Kaboru, Berthollet Bwira

    2013-01-01

    Background and objective: The involvement of traditional healthcare providers (THPs) has been suggested among strategies to increase tuberculosis case detection. Burkina Faso has embarked on such an attempt. This study is a preliminary assessment of that model. Methods: Qualitative data were collected using unstructured key informant interviews with policy makers, group interviews with THPs and health workers, and field visits to THPs. Quantitative data were collected from program reports and the national tuberculosis (TB) control database. Results and analysis: The distribution of tasks among THPs, intermediary organizations and clinicians is appealing, especially the focus on active referral. THPs are offered incentives based on numbers of suspected cases confirmed by health workers at the clinic, based on microscopy results or clinical assessment. The positivity rate was 23% and 9% for 2006 and 2007, respectively. The contribution of the program to national case detection was estimated at 2% for 2006. Because it relied totally on donor funding, the program suffered from irregular disbursements, resulting in periodic decreases in activities and outcomes. Conclusions: The study shows that single interventions require a broader positive policy environment to be sustainable. Even if the active referral approach seems effective in enhancing TB case detection, more complex policy work and direction, domestic financial contribution and additional evidence for cost-effectiveness are needed before the approach can be established as a national policy. PMID:24359717

  11. Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations

    SciTech Connect

    Spraggon, Glen; Hornsby, Michael; Shipway, Aaron; Tully, David C.; Bursulaya, Badry; Danahay, Henry; Harris, Jennifer L.; Lesley, Scott A.

    2010-01-12

    Prostasin or human channel-activating protease 1 has been reported to play a critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel. Here, the structure of the extracellular portion of the membrane associated serine protease has been solved to high resolution in complex with a nonselective d-FFR chloromethyl ketone inhibitor, in an apo form, in a form where the apo crystal has been soaked with the covalent inhibitor camostat and in complex with the protein inhibitor aprotinin. It was also crystallized in the presence of the divalent cation Ca{sup +2}. Comparison of the structures with each other and with other members of the trypsin-like serine protease family reveals unique structural features of prostasin and a large degree of conformational variation within specificity determining loops. Of particular interest is the S1 subsite loop which opens and closes in response to basic residues or divalent ions, directly binding Ca{sup +2} cations. This induced fit active site provides a new possible mode of regulation of trypsin-like proteases adapted in particular to extracellular regions with variable ionic concentrations such as the outer membrane layer of the epithelial cell.

  12. Monte Carlo modeling provides accurate calibration factors for radionuclide activity meters.

    PubMed

    Zagni, F; Cicoria, G; Lucconi, G; Infantino, A; Lodi, F; Marengo, M

    2014-12-01

    Accurate determination of calibration factors for radionuclide activity meters is crucial for quantitative studies and in the optimization step of radiation protection, as these detectors are widespread in radiopharmacy and nuclear medicine facilities. In this work we developed the Monte Carlo model of a widely used activity meter, using the Geant4 simulation toolkit. More precisely the "PENELOPE" EM physics models were employed. The model was validated by means of several certified sources, traceable to primary activity standards, and other sources locally standardized with spectrometry measurements, plus other experimental tests. Great care was taken in order to accurately reproduce the geometrical details of the gas chamber and the activity sources, each of which is different in shape and enclosed in a unique container. Both relative calibration factors and ionization current obtained with simulations were compared against experimental measurements; further tests were carried out, such as the comparison of the relative response of the chamber for a source placed at different positions. The results showed a satisfactory level of accuracy in the energy range of interest, with the discrepancies lower than 4% for all the tested parameters. This shows that an accurate Monte Carlo modeling of this type of detector is feasible using the low-energy physics models embedded in Geant4. The obtained Monte Carlo model establishes a powerful tool for first instance determination of new calibration factors for non-standard radionuclides, for custom containers, when a reference source is not available. Moreover, the model provides an experimental setup for further research and optimization with regards to materials and geometrical details of the measuring setup, such as the ionization chamber itself or the containers configuration.

  13. Review of international geothermal activities and assessment of US industry opportunities: Final report

    SciTech Connect

    Not Available

    1987-08-01

    This study was initiated to review and assess international developments in the geothermal energy field and to define business opportunities for the US geothermal industry. The report establishes data bases on the status of worldwide geothermal development and the competitiveness of US industry. Other factors identified include existing legislation, tax incentives, and government institutions or agencies and private sector organizations that promote geothermal exports. Based on the initial search of 177 countries and geographic entities, 71 countries and areas were selected as the most likely targets for the expansion of the geothermal industry internationally. The study then determined to what extent their geothermal resource had been developed, what countries had aided or participated in this development, and what plans existed for future development. Data on the energy, economic, and financial situations were gathered.

  14. Review of international geothermal activities and assessment of US industry opportunities: Summary report

    SciTech Connect

    Not Available

    1987-08-01

    This report summarizes a study initiated to review and assess international developments in the geothermal energy field and to define business opportunities for the US geothermal industry. The report establishes data bases on the status of worldwide geothermal development and the competitiveness of US industry. Other factors identified include existing legislation, tax incentives, and government institutions or agencies and private sector organizations that promote geothermal exports. Based on the initial search of 177 countries and geographic entities, 71 countries and areas were selected as the most likely targets for the expansion of the geothermal industry internationally. The study then determined to what extent their geothermal resource had been developed, what countries had aided or participated in this development, and what plans existed for future development. Data on the energy, economic, and financial situations were gathered.

  15. LM-research opportunities and activities at the Latvian Academy of Sciences

    SciTech Connect

    Lielausis, O.

    1996-06-01

    In this presentation selected examples will be considered characterizing the breadth of their interests in LM applications. So, InGaSn eutectic was used as a modeling liquid for investigation of MHD effects typical to some LM-blanket configurations. LM coatings proposed for the protection of divertor plates were considered too. Experiments were performed on a superconducting magnet providing a 5.6 T magnetic field in a 30 liters bore. In a large vacuum chamber (12 m{sup 3}; 6.65 10{sup {minus}4} Pa) lithium cooling system for high temperature reactors was examined. Electromagnetic pumps and flowmeters able to work at lithium temperatures up to 960{degrees}C were tested. A Na loop, where two mounted in line electromagnetic pumps are delivering a 25 atm. pressure. The main Na loop equipped with em. pumps is based on a d=10 cm tubing. LM devices were installed in the Latvian 500 MW nuclear research reactor IRT-5000 too. First, a equipped with conductive e.m. pumps loop, where InGaSn serves as a {gamma}-carrier from activity generator (placed close to the core) to two outer 20 Mrad/h irradiators. Second, a LM system for rector control, where contained in InGaSn indium is used for neutron absorption and reactivity control. A closed cylindrical LM container was installed in the core instead of a traditional control rod. The container is divided in two chambers by means of elastic membranes. The one chamber contains InGaSn, the second GaSn (without In). By means of e.m. pumps the proportion between InGaSn and GaSn in the active zone can be changed ensuring a possibility to control the amount of introduced in the core absorbing material. Long term tests of the system were performed on a zero-power assembly. But for a shorter time the system was inserted in the core of the acting main reactor too and the efficiency of the control was confirmed.

  16. A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation.

    PubMed

    Cheng, Tat Cheung; Akey, Ildikó V; Yuan, Shujun; Yu, Zhiheng; Ludtke, Steven J; Akey, Christopher W

    2017-01-03

    In Drosophila, the Apaf-1-related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have determined a near-atomic structure of Dark double rings using cryo-electron microscopy. We then built a nearly complete model of the apoptosome that includes 7- and 8-blade β-propellers. We find that the preference for dATP during Dark assembly may be governed by Ser325, which is in close proximity to the 2' carbon of the deoxyribose ring. Interestingly, β-propellers in V-shaped domains of the Dark apoptosome are more widely separated, relative to these features in the Apaf-1 apoptosome. This wider spacing may be responsible for the lack of cytochrome c binding to β-propellers in the Dark apoptosome. Our structure also highlights the roles of two loss-of-function mutations that may block Dark assembly. Finally, the improved model provides a framework to understand apical procaspase activation in the intrinsic cell death pathway.

  17. Telementoring: Providing Authentic Learning Opportunities for Students.

    ERIC Educational Resources Information Center

    Adams, Helen

    1999-01-01

    Describes the Hewlett Packard (HP) E-Mail Mentoring Program. Lists the program's four main components (teacher contacts, student participants, HP employee members, HP itself) and the application process. Relates how a library media specialist at Rosholt (Wisconsin) High School experienced the program. Concludes with the benefits of…

  18. Equal Opportunities for Spanish-Speaking People. Hearings Before the Civil Rights and Constitutional Rights Subcommittee of the Committee on the Judiciary, House of Representatives, Ninety-third Congress, First Session on the Role of the Cabinet Committee on Opportunities for Spanish-Speaking People in Providing Equal Opportunities for Spanish-Speaking People (July 11 and 19, 1973).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on the Judiciary.

    The statutory purpose of the Cabinet Committee on Opportunities for the Spanish Speaking People, established in December 1969, is twofold: (1) to assure that Federal programs are reaching all Spanish-speaking and Spanish-surnamed Americans, and (2) to seek out new programs which may be necessary to handle problems unique to such persons. On July…

  19. Increasing Student Physical Activity during the School Day: Opportunities for the Physical Educator

    ERIC Educational Resources Information Center

    Brewer, Joan D.; Luebbers, Paul E.; Shane, Shawna D.

    2009-01-01

    America is facing an obesity epidemic--one that is difficult to ignore. In order to combat the nation's obesity crisis, it is imperative that schools find ways to increase the physical activity levels of students during the school day, as well as encourage additional activity outside of school. By teaching youth to incorporate physical activity…

  20. Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy

    PubMed Central

    Dufait, Inès; Van Valckenborgh, Els; Menu, Eline; Escors, David; De Ridder, Mark; Breckpot, Karine

    2016-01-01

    Cancer progression is in part determined by interactions between cancer cells and stromal cells in the tumor microenvironment (TME). The identification of cytotoxic tumor-infiltrating lymphocytes has instigated research into immune stimulating cancer therapies. Although a promising direction, immunosuppressive mechanisms exerted at the TME hamper its success. Myeloid-derived suppressor cells (MDSCs) have come to the forefront as stromal cells that orchestrate the immunosuppressive TME. Consequently, this heterogeneous cell population has been the object of investigation. Studies revealed that the transcription factor signal transducer and activator of transcription 3 (STAT3) largely dictates the recruitment, activation and function of MDSCs in the TME. Therefore, this review will focus on the role of this key transcription factor during the MDSC's life cycle and on the therapeutic opportunities it offers. PMID:27029037

  1. Immunization of stromal cell targeting fibroblast activation protein providing immunotherapy to breast cancer mouse model.

    PubMed

    Meng, Mingyao; Wang, Wenju; Yan, Jun; Tan, Jing; Liao, Liwei; Shi, Jianlin; Wei, Chuanyu; Xie, Yanhua; Jin, Xingfang; Yang, Li; Jin, Qing; Zhu, Huirong; Tan, Weiwei; Yang, Fang; Hou, Zongliu

    2016-08-01

    Unlike heterogeneous tumor cells, cancer-associated fibroblasts (CAF) are genetically more stable which serve as a reliable target for tumor immunotherapy. Fibroblast activation protein (FAP) which is restrictively expressed in tumor cells and CAF in vivo and plays a prominent role in tumor initiation, progression, and metastasis can function as a tumor rejection antigen. In the current study, we have constructed artificial FAP(+) stromal cells which mimicked the FAP(+) CAF in vivo. We immunized a breast cancer mouse model with FAP(+) stromal cells to perform immunotherapy against FAP(+) cells in the tumor microenvironment. By forced expression of FAP, we have obtained FAP(+) stromal cells whose phenotype was CD11b(+)/CD34(+)/Sca-1(+)/FSP-1(+)/MHC class I(+). Interestingly, proliferation capacity of the fibroblasts was significantly enhanced by FAP. In the breast cancer-bearing mouse model, vaccination with FAP(+) stromal cells has significantly inhibited the growth of allograft tumor and reduced lung metastasis indeed. Depletion of T cell assays has suggested that both CD4(+) and CD8(+) T cells were involved in the tumor cytotoxic immune response. Furthermore, tumor tissue from FAP-immunized mice revealed that targeting FAP(+) CAF has induced apoptosis and decreased collagen type I and CD31 expression in the tumor microenvironment. These results implicated that immunization with FAP(+) stromal cells led to the disruption of the tumor microenvironment. Our study may provide a novel strategy for immunotherapy of a broad range of cancer.

  2. Medical students' opportunities to participate and learn from activities at an internal medicine ward: an ethnographic study

    PubMed Central

    Hägg-Martinell, A; Hult, H; Henriksson, P; Kiessling, A

    2017-01-01

    Objectives To optimise medical students’ early clerkship is a complex task since it is conducted in a context primarily organised to take care of patients. Previous studies have explored medical students’ perceptions of facilitation and hindrance of learning. However, the opportunities for medical student to learn within the culture of acute medicine care have not been fully investigated. This study aimed to explore how medical students approach, interact and socialise in an acute internal medicine ward context, and how spaces for learning are created and used in such a culture. Design and setting Ethnographic observations were performed of medical students' interactions and learning during early clerkship at an acute internal medicine care ward. Field notes were taken, transcribed and analysed qualitatively. Data analysis was guided by Wenger's theory of communities of practice. Participants 21 medical students and 30 supervisors participated. Results Two themes were identified: Nervousness and curiosity—students acted nervously and stressed, especially when they could not answer questions. Over time curiosity could evolve. Unexplored opportunities to support students in developing competence to judge and approach more complex patient-related problems were identified. Invited and involved—students were exposed to a huge variation of opportunities to learn, and to interact and to be involved. Short placements seemed to disrupt the learning process. If and how students became involved also depended on supervisors' activities and students' initiatives. Conclusions This study shed light on how an acute internal medicine ward culture can facilitate medical students' possibilities to participate and learn. Medical students' learning situations were characterised by questions and answers rather than challenging dialogues related to the complexity of presented patient cases. Further, students experienced continuous transfers between learning situations where the

  3. Physical activity, sedentary behaviour and energy balance in the preschool child: opportunities for early obesity prevention.

    PubMed

    Reilly, John J

    2008-08-01

    Prevalence of obesity in preschool children has increased dramatically in recent years. The preschool years (age 3-6 years) have been regarded as critical for the programming of energy balance, via the concept of early 'adiposity rebound'. Children who undergo early adiposity rebound are at increased risk of later obesity. Recent evidence suggests that associations between timing of adiposity rebound and later obesity may not reflect programming, but might denote that 'obesogenic' growth trajectories are often established by the preschool period. Studies of objectively-measured physical activity and sedentary behaviour in preschool children show that levels of physical activity are typically low and sedentary behaviour high. The review of evidence presented here is supportive of the hypothesis that physical activity is protective against obesity in the preschool period, and that sedentary behaviour, particularly television viewing, is obesogenic. Definitive evidence on dose-response relationships between physical activity, sedentary behaviour and obesity remain unclear. Dose-response evidence could be obtained fairly readily by intervention and longitudinal observational studies that use accelerometry in preschool children. The generalisability of much of the evidence base is limited and there is a need for research on the influence of physical activity and sedentary behaviour in the preschool years in the aetiology of obesity in the developing world.

  4. Physical Activity Opportunities during the School Day: Classroom Teachers' Perceptions of Using Activity Breaks in the Classroom

    ERIC Educational Resources Information Center

    McMullen, Jaimie; Kulinna, Pamela; Cothran, Donetta

    2014-01-01

    The purpose of this study was to explore classroom teachers' perceptions of incorporating physical activity breaks into their classroom and to determine specific features of preferred activity breaks. These perceptions are considered within the conceptual framework of Comprehensive School Physical Activity Program (CSPAP). Twelve elementary and…

  5. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  6. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  7. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  8. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  9. 42 CFR 495.364 - Review and assessment of administrative activities and expenses of Medicaid provider health...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and expenses of Medicaid provider health information technology adoption and operation. 495.364... administrative activities and expenses of Medicaid provider health information technology adoption and operation... its approved HIT planning advance planning document and health information technology...

  10. Opportunities for Increased Physical Activity in the Workplace: the Walking Meeting (WaM) Pilot Study, Miami, 2015

    PubMed Central

    Kling, Hannah E.; Yang, Xuan; Messiah, Sarah E.; Arheart, Kristopher L.; Brannan, Debi

    2016-01-01

    Introduction Despite the positive impact walking has on human health, few opportunities exist for workers with largely sedentary jobs to increase physical activity while at work. The objective of this pilot study was to examine the implementation, feasibility, and acceptability of using a Walking Meeting (WaM) protocol to increase the level of work-related physical activity among a group of sedentary white-collar workers. Methods White-collar workers at a large university were invited to participate in a newly developed WaM protocol. Workers who conducted weekly meetings in groups of 2 or 3 individuals were recruited for the pilot study (n = 18) that took place from January 2015 to August 2015. Seventeen participants wore an accelerometer to measure physical activity levels during 3 consecutive weeks (first week baseline, followed by 2 weeks of organized WaMs) and participated in focus groups conducted during week 3 to document experiences with the WaM protocol. Results The WaM protocol met study criteria on feasibility, implementation, and acceptability among study participants. The average number of minutes (standard deviation) participants engaged in combined work-related moderate/vigorous physical activity per week during the 3 weeks increased from an average of 107 (55) minutes during the baseline week to 114 (67) minutes at week 2 and to 117 (65) minutes at week 3. Conclusion White- collar workers were supportive of transforming regular seated meetings into walking meetings and increased their work-related physical activity levels. PMID:27337560

  11. 45 CFR 287.120 - What work activities may be provided under the NEW Program?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., alternative education, post secondary education, job readiness activity, job search, job skills training, training and employment activities, job development and placement, on-the-job training (OJT), employer work... employment services, job retention services, unsubsidized employment, subsidized public or private...

  12. 45 CFR 287.120 - What work activities may be provided under the NEW Program?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., alternative education, post secondary education, job readiness activity, job search, job skills training, training and employment activities, job development and placement, on-the-job training (OJT), employer work... employment services, job retention services, unsubsidized employment, subsidized public or private...

  13. Missed Opportunities to Keep Children Safe? National Survey of Injury Prevention Activities of Children's Centres

    ERIC Educational Resources Information Center

    Watson, Michael Craig; Mulvaney, Caroline; Timblin, Clare; Stewart, Jane; Coupland, Carol A.; Deave, Toity; Hayes, Mike; Kendrick, Denise

    2016-01-01

    Objective: To ascertain the activities undertaken by children's centres to prevent unintentional injuries in the under-fives and, in particular, the prevention of falls, poisoning and scalds. Design: A questionnaire was posted to managers of 851 children's centres, using stratified cluster sampling. The questionnaire included questions on injury…

  14. Institutional Review Boards at Very High Research Activity Universities: An Opportunity for Social Workers

    ERIC Educational Resources Information Center

    Cannon, Clare; Buttell, Frederick

    2015-01-01

    Objectives: This study investigated to what degree social work was represented in the position of chair of social-behavioral institutional review boards (IRBs) at very high research activity (VHRA) universities in the United States. Method: We collected data on IRB rosters for all 108 schools designated by the Carnegie Foundation as VHRAs in the…

  15. NASA’s Soil Moisture Active Passive (SMAP) mission and opportunities for applications users

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil Moisture Active Passive (SMAP) mission is one of four first-tier missions recommended by the National Research Council's Committee on Earth Science and Applications from Space. Set to launch in 2014, SMAP soil moisture and freeze/thaw measurements will have an accuracy, resolution, and glob...

  16. FOSTERING APPLICATIONS OPPORTUNITIES FOR THE NASA SOIL MOISTURE ACTIVE PASSIVE (SMAP) MISSION

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil Moisture Active Passive (SMAP) Mission is one of the first Earth observation satellites being developed by NASA in response to the National Research Council’s (NRC’s) Decadal Survey, Earth Science and Applications from Space: National Imperatives for the Next Decade and Beyond. SMAP will ma...

  17. State opportunities for action: Update of states' combined heat and power activities

    SciTech Connect

    Brown, Elizabeth; Elliott, R. Neal

    2003-10-01

    This report updates the review of state policies with regard to CHP that the American Council for and Energy Efficient Economy completed in 2002. It describes the current activities of states with programs during the initial survey and also reviews new programs offered by the states.

  18. 36 CFR 218.24 - Notification of opportunity to comment on proposed projects and activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... availability (NOA) in the Federal Register (see § 218.25(a)(2)). The legal notice must be published after the NOA and contain the NOA publication date. (6) A statement that only those who submit timely and... activity to be analyzed and documented in an EA. The publication date of the NOA in the Federal Register...

  19. 36 CFR 218.24 - Notification of opportunity to comment on proposed projects and activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... availability (NOA) in the Federal Register (see § 218.25(a)(2)). The legal notice must be published after the NOA and contain the NOA publication date. (6) A statement that only those who submit timely and... activity to be analyzed and documented in an EA. The publication date of the NOA in the Federal Register...

  20. Providing Physical Activity for Students with Intellectual Disabilities: The Motivate, Adapt, and Play Program

    ERIC Educational Resources Information Center

    Davis, Kathy; Hodson, Patricia; Zhang, Guili; Boswell, Boni; Decker, Jim

    2010-01-01

    Research has shown that regular physical activity helps to prevent major health problems, such as heart disease, obesity, and diabetes. However, little research has been conducted on classroom-based physical activity programs for students with disabilities. In North Carolina, the Healthy Active Children Policy was implemented in 2006, requiring…

  1. 2013 Workplace and Equal Opportunity Survey of Active Duty Members: Overview Report

    DTIC Science & Technology

    2014-10-01

    the military have changed over time. The findings provide general perceptions of whether Service members thought that race relations have improved ...received poorer treatment than you deserved from a military health care provider. • You were harassed by armed forces police. 1.9 1.3 3.0 1.9 1.3 0.9 0 20...24% 33% 15% 35% 31% NR 36% 38% 28% At a military non-work location (for example, gym , quarters/housing, exchange/commissary, bowling alley)? 21

  2. Seizing Opportunity: "Opportunity as Transformation"

    ERIC Educational Resources Information Center

    Williams, Michael; Muller, Esther

    2012-01-01

    Opportunity creates conditions for achievement. We learn daily of the success of others that resulted from conditions they created through opportunity. Often these conditions of opportunity are the product of a compelling vision of a future steeped in possibility and rich in reward. These visions, however, must be operationalized in order to be…

  3. Alkyl Galactofuranosides Strongly Interact with Leishmania donovani Membrane and Provide Antileishmanial Activity

    PubMed Central

    Suleman, Muhammad; Gangneux, Jean-Pierre; Legentil, Laurent; Belaz, Sorya; Cabezas, Yari; Manuel, Christelle; Dureau, Rémy; Sergent, Odile; Burel, Agnès; Daligault, Franck; Ferrières, Vincent

    2014-01-01

    We investigated the in vitro effects of four alkyl-galactofuranoside derivatives, i.e., octyl-β-d-galactofuranoside (compound 1), 6-amino-β-d-galactofuranoside (compound 2), 6-N-acetamido-β-d-galactofuranoside (compound 3), and 6-azido-β-d-galactofuranoside (compound 4), on Leishmania donovani. Their mechanism of action was explored using electron paramagnetic resonance spectroscopy (EPR) and nuclear magnetic resonance (NMR), and ultrastructural alterations were analyzed by transmission electron microscopy (TEM). Compound 1 showed the most promising effects by inhibiting promastigote growth at a 50% inhibitory concentration (IC50) of 8.96 ± 2.5 μM. All compounds exhibit low toxicity toward human macrophages. Compound 1 had a higher selectivity index than the molecule used for comparison, i.e., miltefosine (159.7 versus 37.9, respectively). EPR showed that compound 1 significantly reduced membrane fluidity compared to control promastigotes and to compound 3. The furanose ring was shown to support this effect, since the isomer galactopyranose had no effect on parasite membrane fluidity or growth. NMR showed a direct interaction of all compounds (greatest with compound 1, followed by compounds 2, 3, and 4, in descending order) with the promastigote membrane and with octyl-galactopyranose and octanol, providing evidence that the n-octyl chain was primarily involved in anchoring with the parasite membrane, followed by the putative crucial role of the furanose ring in the antileishmanial activity. A morphological analysis of compound 1-treated promastigotes by TEM revealed profound alterations in the parasite membrane and organelles, but this was not the case with compound 3. Quantification of annexin V binding by flow cytometry confirmed that compound 1 induced apoptosis in >90% of promastigotes. The effect of compound 1 was also assessed on intramacrophagic amastigotes and showed a reduction in amastigote growth associated with an increase of reactive oxygen

  4. Alkyl galactofuranosides strongly interact with Leishmania donovani membrane and provide antileishmanial activity.

    PubMed

    Suleman, Muhammad; Gangneux, Jean-Pierre; Legentil, Laurent; Belaz, Sorya; Cabezas, Yari; Manuel, Christelle; Dureau, Rémy; Sergent, Odile; Burel, Agnès; Daligault, Franck; Ferrières, Vincent; Robert-Gangneux, Florence

    2014-01-01

    We investigated the in vitro effects of four alkyl-galactofuranoside derivatives, i.e., octyl-β-D-galactofuranoside (compound 1), 6-amino-β-D-galactofuranoside (compound 2), 6-N-acetamido-β-D-galactofuranoside (compound 3), and 6-azido-β-D-galactofuranoside (compound 4), on Leishmania donovani. Their mechanism of action was explored using electron paramagnetic resonance spectroscopy (EPR) and nuclear magnetic resonance (NMR), and ultrastructural alterations were analyzed by transmission electron microscopy (TEM). Compound 1 showed the most promising effects by inhibiting promastigote growth at a 50% inhibitory concentration (IC50) of 8.96±2.5 μM. All compounds exhibit low toxicity toward human macrophages. Compound 1 had a higher selectivity index than the molecule used for comparison, i.e., miltefosine (159.7 versus 37.9, respectively). EPR showed that compound 1 significantly reduced membrane fluidity compared to control promastigotes and to compound 3. The furanose ring was shown to support this effect, since the isomer galactopyranose had no effect on parasite membrane fluidity or growth. NMR showed a direct interaction of all compounds (greatest with compound 1, followed by compounds 2, 3, and 4, in descending order) with the promastigote membrane and with octyl-galactopyranose and octanol, providing evidence that the n-octyl chain was primarily involved in anchoring with the parasite membrane, followed by the putative crucial role of the furanose ring in the antileishmanial activity. A morphological analysis of compound 1-treated promastigotes by TEM revealed profound alterations in the parasite membrane and organelles, but this was not the case with compound 3. Quantification of annexin V binding by flow cytometry confirmed that compound 1 induced apoptosis in >90% of promastigotes. The effect of compound 1 was also assessed on intramacrophagic amastigotes and showed a reduction in amastigote growth associated with an increase of reactive oxygen

  5. Opportunities for Low Cost Processing of Erbium 8-Quinolinolates for Active Integrated Photonic Applications.

    PubMed

    Penna, Stefano; Mattiello, Leonardo; Di Bartolo, Silvia; Pizzoleo, Angelo; Attanasio, Vincenzo; Beleffi, Giorgio Maria Tosi; Otomo, Akira

    2016-04-01

    Erbium-doped organic emitters are promising active materials for Photonic Integrated Circuits (PICs) due to their emission shown at 1550 nm combined to the potential low cost processing. In particular, Erbium Quinoline (ErQ) gained a strong interest in the last decade for the good emission efficiency. This contribution reports the results derived from the application of ErQ as active core material within a buried optical waveguide, following the development of a purposed optical process to control the refractive index of ErQ and then to define a patterned structure from a single thin film deposition step. The reported results show the potential of Er-doped organic materials for low cost processing and application to planar PICs.

  6. NASA plans and opportunities. [space flight activities throughout the 1990s

    NASA Technical Reports Server (NTRS)

    Sulzman, Frank M.

    1991-01-01

    The NASA plans for the Life Science program of a series of space flight activities throughout the decade of the 1990s are discussed with particular attention given to the NASA life science goals and objectives and to the particular space missions which will carry out these objectives. These space missions and specially designed facilities for experiments in space include Space Station Freedom, Space Biology Initiative, Gravitational Biology Facility, Life Sciences Centrifuge Facility, Controlled Ecological Life Support Systems Test Facility, and Exobiology Facility.

  7. 2013 Workplace and Equal Opportunity Survey of Active Duty Members: Tabulations Responses

    DTIC Science & Technology

    2014-03-01

    214  e.  Displayed tattoos or wore distinctive clothes which were racist? ........ 216  f.  Did not include you in social activities...and/or contractors (in your workplace or on or off your installation/ship)... e. Displayed tattoos or wore distinctive clothes which were racist...contractors (in your workplace or on or off your installation/ship)... e. Displayed tattoos or wore distinctive clothes which were racist? Percent

  8. When conditioned responses "fire back": bidirectional cross-activation creates learning opportunities in synesthesia.

    PubMed

    Meier, B; Rothen, N

    2007-07-13

    In grapheme-color synesthesia, the letter "c" printed in black may be experienced as red, but typically the color red does not trigger the experience of the letter "c." Therefore, at the level of subjective experience, cross-activation is usually unidirectional. However, recent evidence from digit-color synesthesia suggests that at an implicit level bidirectional cross-activation can occur. Here we demonstrate that this finding is not restricted to this specific type of synesthesia. We introduce a new method that enables the investigation of bidirectionality in other types of synesthesia. We found that a group of grapheme-color synesthetes, but not a control group, showed a startle in response to a color-inducing grapheme after a startle response was conditioned to the specific corresponding color. These results implicate that when the startle response was associated with the real color an association between shock and the grapheme was also established. By this mechanism (i.e. implicit cross-activation) the conditioned response to the real color generalized to the synesthetic color. We suggest that parietal brain areas are responsible for this neural backfiring.

  9. 77 FR 66869 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Provider...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ...; Provider Enrollment Form ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting the Office of..., ``Provider Enrollment Form,'' to the Office of Management and Budget (OMB) for review and approval for use in...: 44 U.S.C. 3507(a)(1)(D). SUPPLEMENTARY INFORMATION: The Provider Enrollment Form (Form OWCP-...

  10. 45 CFR 287.120 - What work activities may be provided under the NEW Program?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., alternative education, post secondary education, job readiness activity, job search, job skills training... employment, community service programs, entrepreneurial training, management training, job...

  11. 34 CFR 646.4 - What activities and services may a project provide?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... necessary for success beyond secondary school. (b) Personal counseling. (c) Academic advice and assistance...) Activities designed to secure admission and financial assistance for enrollment in graduate and...

  12. 45 CFR 287.120 - What work activities may be provided under the NEW Program?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Program? 287.120 Section 287.120 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY..., alternative education, post secondary education, job readiness activity, job search, job skills training, training and employment activities, job development and placement, on-the-job training (OJT), employer...

  13. 45 CFR 287.120 - What work activities may be provided under the NEW Program?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Program? 287.120 Section 287.120 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY..., alternative education, post secondary education, job readiness activity, job search, job skills training, training and employment activities, job development and placement, on-the-job training (OJT), employer...

  14. Service Providers' Perceptions of Active Ageing among Older Adults with Lifelong Intellectual Disabilities

    ERIC Educational Resources Information Center

    Buys, L.; Aird, R.; Miller, E.

    2012-01-01

    Background: Considerable attention is currently being directed towards both active ageing and the revising of standards for disability services within Australia and internationally. Yet, to date, no consideration appears to have been given to ways to promote active ageing among older adults with intellectual disabilities (IDs). Methods:…

  15. Equal Opportunities for Women in Marine Sciences in Kiel: Activities and Measures

    NASA Astrophysics Data System (ADS)

    Kamm, Ruth

    2016-04-01

    Women are still largely underrepresented in geosciences in general. Particularly at the level of professorships and permanent research staff positions this also applies to marine science institutions in Kiel, i.e. the research focus Kiel Marine Sciences at Kiel University and the GEOMAR Helmholtz Centre for Ocean Research Kiel. Both institutions are closely collaborating, for instance in the frame of two major third-party funded collaborative projects: The Cluster of Excellence 'The Future Ocean', funded within the German Excellence Initiative, and the Collaborative Research Centre 'Climate - Biogeochemistry Interactions in the Tropical Ocean' (SFB 754) financed through the German Research Foundation (DFG). Both funding schemes request for measures to increase the participation of female scientists in leading positions. As an innovative approach, The Future Ocean and SFB 754 jointly finance the position of a coordinator for gender measures who is based at the university's Central Office for Gender Equality, Diversity & Family since 2012. This allows for the coordinated development and implementation of programmes to support female marine scientists, with a focus on the postdoctoral phase, and to offer a broader spectrum of activities to raise awareness of gender imbalance in the research community. The aim of this presentation is to give insight into activities and achievements, among them the mentoring programme via:mento_ocean for female postdocs in marine sciences. The programme via:mento_ocean has been acknowledged as a best practice instrument to support women scientists in a close disciplinary but international setting and was incorporated into the DFG's online toolbox of gender equality measures.

  16. 20 CFR 665.300 - What are rapid response activities and who is responsible for providing them?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are rapid response activities and who is responsible for providing them? 665.300 Section 665.300 Employees' Benefits EMPLOYMENT AND TRAINING... INVESTMENT ACT Rapid Response Activities § 665.300 What are rapid response activities and who is...

  17. 20 CFR 665.300 - What are rapid response activities and who is responsible for providing them?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false What are rapid response activities and who is responsible for providing them? 665.300 Section 665.300 Employees' Benefits EMPLOYMENT AND TRAINING... WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.300 What are rapid response activities and who...

  18. Hawai‘i's Opportunity for Active Living Advancement (HO‘ĀLA): Addressing Childhood Obesity through Safe Routes to School

    PubMed Central

    Dierenfield, Laura; Alexander, Daniel A; Prose, Marcia; Peterson, Ann C

    2011-01-01

    Increasing active transportation to and from school may reduce childhood obesity rates in Hawai‘i. A community partnership was formed to address this issue in Hawai‘i's Opportunity for Active Living Advancement (HO‘ĀLA), a quasi-experimental study of active transportation in Hawai‘i County. The purpose of this study was to determine baseline rates for active transportation rates to and from school and to track changes related to macro-level (statewide) policy, locally-based Safe Routes to School (SRTS) programs and bicycle and pedestrian planning initiatives expected to improve the safety, comfort and ease of walking and bicycling to and from school. Measures included parent surveys, student travel tallies, traffic counts and safety observations. Assessments of the walking and biking environment around each school were made using the Pedestrian Environment Data Scan. Complete Streets and SRTS policy implementation was tracked through the activities of a state transportation-led Task Force and an advocacy-led coalition, respectively. Planning initiatives were tracked through citizen-based advisory committees. Thirteen volunteer schools participated as the intervention (n=8) or comparison (n=5) schools. The majority of students were Asian, Native Hawaiian, and Pacific Islander in schools located in under-resourced communities. Overall, few children walked or biked to school. The majority of children were driven to and from school by their parents. With the influence of HO‘ĀLA staff members, two intervention schools were obligated SRTS project funding from the state, schools were identified as key areas in the pedestrian master plan, and one intervention school was slated for a bike plan priority project. As the SRTS programs are implemented in the next phase of the project, post-test data will be collected to ascertain if changes in active transportation rates occur. PMID:21886289

  19. Hawai'i's Opportunity for Active Living Advancement (HO'ĀLA): addressing childhood obesity through safe routes to school.

    PubMed

    Heinrich, Katie M; Dierenfield, Laura; Alexander, Daniel A; Prose, Marcia; Peterson, Ann C

    2011-07-01

    Increasing active transportation to and from school may reduce childhood obesity rates in Hawai'i. A community partnership was formed to address this issue in Hawai'i's Opportunity for Active Living Advancement (HO'ĀLA), a quasi-experimental study of active transportation in Hawai'i County. The purpose of this study was to determine baseline rates for active transportation rates to and from school and to track changes related to macro-level (statewide) policy, locally-based Safe Routes to School (SRTS) programs and bicycle and pedestrian planning initiatives expected to improve the safety, comfort and ease of walking and bicycling to and from school. Measures included parent surveys, student travel tallies, traffic counts and safety observations. Assessments of the walking and biking environment around each school were made using the Pedestrian Environment Data Scan. Complete Streets and SRTS policy implementation was tracked through the activities of a state transportation-led Task Force and an advocacy-led coalition, respectively. Planning initiatives were tracked through citizen-based advisory committees. Thirteen volunteer schools participated as the intervention (n=8) or comparison (n=5) schools. The majority of students were Asian, Native Hawaiian, and Pacific Islander in schools located in under-resourced communities. Overall, few children walked or biked to school. The majority of children were driven to and from school by their parents. With the influence of HO'ĀLA staff members, two intervention schools were obligated SRTS project funding from the state, schools were identified as key areas in the pedestrian master plan, and one intervention school was slated for a bike plan priority project. As the SRTS programs are implemented in the next phase of the project, post-test data will be collected to ascertain if changes in active transportation rates occur.

  20. 77 FR 56712 - Agency Information Collection (Homeless Providers Grant and Per Diem Program) Activities Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... Providers Grant and Per Diem Program, Special Needs Application, VA Form 10-0361-SN. e. Compliance Reports for Per Diem and Special Needs Grants. No form needed. May be reported to VA in standard business.... Homeless Providers Grant and Per Diem Program, Special Needs Application, VA Form 10-0361-SN--4,000...

  1. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Additional provider and supplier requirements for... on the type of services or supplies the provider or supplier type will furnish and bill Medicare. (3...) Reporting requirements DMEPOS suppliers. DMEPOS reporting requirements are specified in § 424.57(c)(2)....

  2. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Additional provider and supplier requirements for... on the type of services or supplies the provider or supplier type will furnish and bill Medicare. (3...) Reporting requirements DMEPOS suppliers. DMEPOS reporting requirements are specified in § 424.57(c)(2)....

  3. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Additional provider and supplier requirements for... on the type of services or supplies the provider or supplier type will furnish and bill Medicare. (3...) Reporting requirements DMEPOS suppliers. DMEPOS reporting requirements are specified in § 424.57(c)(2)....

  4. 42 CFR 424.516 - Additional provider and supplier requirements for enrolling and maintaining active enrollment...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Additional provider and supplier requirements for... on the type of services or supplies the provider or supplier type will furnish and bill Medicare. (3...) Reporting requirements DMEPOS suppliers. DMEPOS reporting requirements are specified in § 424.57(c)(2)....

  5. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... children and youths; and (ii) Foster care youths. (6) Programs and activities as described in paragraph (a... children and youths, students who are foster care youth, or other disconnected students. (7)...

  6. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... children and youths; and (ii) Foster care youths. (6) Programs and activities as described in paragraph (a... children and youths, students who are foster care youth, or other disconnected students. (7)...

  7. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... children and youths; and (ii) Foster care youths. (6) Programs and activities as described in paragraph (a... children and youths, students who are foster care youth, or other disconnected students. (7)...

  8. 34 CFR 646.4 - What activities and services does a project provide?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... children and youths; and (ii) Foster care youths. (6) Programs and activities as described in paragraph (a... children and youths, students who are foster care youth, or other disconnected students. (7)...

  9. Differential activation of an identified motor neuron and neuromodulation provide Aplysia's retractor muscle an additional function.

    PubMed

    McManus, Jeffrey M; Lu, Hui; Cullins, Miranda J; Chiel, Hillel J

    2014-08-15

    To survive, animals must use the same peripheral structures to perform a variety of tasks. How does a nervous system employ one muscle to perform multiple functions? We addressed this question through work on the I3 jaw muscle of the marine mollusk Aplysia californica's feeding system. This muscle mediates retraction of Aplysia's food grasper in multiple feeding responses and is innervated by a pool of identified neurons that activate different muscle regions. One I3 motor neuron, B38, is active in the protraction phase, rather than the retraction phase, suggesting the muscle has an additional function. We used intracellular, extracellular, and muscle force recordings in several in vitro preparations as well as recordings of nerve and muscle activity from intact, behaving animals to characterize B38's activation of the muscle and its activity in different behavior types. We show that B38 specifically activates the anterior region of I3 and is specifically recruited during one behavior, swallowing. The function of this protraction-phase jaw muscle contraction is to hold food; thus the I3 muscle has an additional function beyond mediating retraction. We additionally show that B38's typical activity during in vivo swallowing is insufficient to generate force in an unmodulated muscle and that intrinsic and extrinsic modulation shift the force-frequency relationship to allow contraction. Using methods that traverse levels from individual neuron to muscle to intact animal, we show how regional muscle activation, differential motor neuron recruitment, and neuromodulation are key components in Aplysia's generation of multifunctionality.

  10. Soil Microbial Activity Provides Insight to Carbon Cycling in Shrub Ecotones of Sub-Arctic Sweden

    NASA Astrophysics Data System (ADS)

    Marek, E.; Kashi, N. N.; Chen, J.; Hobbie, E. A.; Schwan, M. R.; Varner, R. K.

    2015-12-01

    Shrubs are expanding in Arctic and sub-Arctic regions due to rising atmospheric temperatures. Microbial activity increases as growing temperatures cause permafrost warming and subsequent thaw, leading to a greater resource of soil nutrients enabling shrub growth. Increased carbon inputs from shrubs is predicted to result in faster carbon turnover by microbial decomposition. Further understanding of microbial activity underneath shrubs could uncover how microbes and soil processes interact to promote shrub expansion and carbon cycling. To address how higher soil carbon input from shrubs influences decomposition, soil samples were taken across a heath, shrub, and forest ecotone gradient at two sites near Abikso, Sweden. Samples were analyzed for soluble carbon and nitrogen, microbial abundance, and microbial activity of chitinase, glucosidase, and phosphatase to reflect organic matter decomposition and availability of nitrogen, carbon, and phosphate respectively. Chitinase activity positively correlated with shrub cover, suggesting microbial demands for nitrogen increase with higher shrub cover. Glucosidase activity negatively correlated with shrub cover and soluble carbon, suggesting decreased microbial demand for carbon as shrub cover and carbon stores increase. Lower glucosidase activity in areas with high carbon input from shrubs implies that microbes are decomposing carbon less readily than carbon is being put into the soil. Increasing soil carbon stores in shrub covered areas can lead to shrubs becoming a net carbon sink and a negative feedback to changing climate.

  11. 30 CFR 250.208 - If I conduct ancillary activities, what notices must I provide?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER... instrumentation/techniques and vessel navigation system you will use; (3) Provide expected start and...

  12. 77 FR 39342 - Proposed Information Collection (Homeless Providers Grant and Per Diem Program) Activity; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... narrative. f. Homeless Providers Grant and Per Diem Program, Technical Assistance Application, VA Form 10... in standard business narrative. OMB Control Number: 2900-0554. Type of Review: Revision of...

  13. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.

    PubMed

    Kong, Qiongman; Chang, Ling-Chu; Takahashi, Kou; Liu, Qibing; Schulte, Delanie A; Lai, Liching; Ibabao, Brian; Lin, Yuchen; Stouffer, Nathan; Das Mukhopadhyay, Chitra; Xing, Xuechao; Seyb, Kathleen I; Cuny, Gregory D; Glicksman, Marcie A; Lin, Chien-Liang Glenn

    2014-03-01

    Glial glutamate transporter EAAT2 plays a major role in glutamate clearance in synaptic clefts. Several lines of evidence indicate that strategies designed to increase EAAT2 expression have potential for preventing excitotoxicity, which contributes to neuronal injury and death in neurodegenerative diseases. We previously discovered several classes of compounds that can increase EAAT2 expression through translational activation. Here, we present efficacy studies of the compound LDN/OSU-0212320, which is a pyridazine derivative from one of our lead series. In a murine model, LDN/OSU-0212320 had good potency, adequate pharmacokinetic properties, no observed toxicity at the doses examined, and low side effect/toxicity potential. Additionally, LDN/OSU-0212320 protected cultured neurons from glutamate-mediated excitotoxic injury and death via EAAT2 activation. Importantly, LDN/OSU-0212320 markedly delayed motor function decline and extended lifespan in an animal model of amyotrophic lateral sclerosis (ALS). We also found that LDN/OSU-0212320 substantially reduced mortality, neuronal death, and spontaneous recurrent seizures in a pilocarpine-induced temporal lobe epilepsy model. Moreover, our study demonstrated that LDN/OSU-0212320 treatment results in activation of PKC and subsequent Y-box-binding protein 1 (YB-1) activation, which regulates activation of EAAT2 translation. Our data indicate that the use of small molecules to enhance EAAT2 translation may be a therapeutic strategy for the treatment of neurodegenerative diseases.

  14. Providing independent recreational activities to reduce stereotypic vocalizations in chronic schizophrenics.

    PubMed Central

    Wong, S E; Terranova, M D; Bowen, L; Zarate, R; Massel, H K; Liberman, R P

    1987-01-01

    We evaluated the effects of minimally supervised, independent recreational activities on stereotypic vocal behavior in two chronic schizophrenic patients. In baseline sessions, subjects were observed during unstructured free time in the psychiatric ward. In treatment sessions, therapists presented preferred recreational materials (magazines, models, and art projects), verbally prompted on-task behavior every 20 min, and, in one condition, administered contingent tokens. Independent recreational activities reduced medium-rate self-talk in one subject and high-rate mumbling in a second subject by 60%-70%. Results were the same with or without contingent tokens. Apparent self-maintaining characteristics of these vocal responses are discussed. PMID:3583965

  15. Outer Hair Cells Provide Active Tuning in the Organ of Corti.

    PubMed

    Ulfendahl, Mats; Flock Å, Åke

    1998-06-01

    The detection of sound by the mammalian hearing organ, the organ of Corti, is far from a passive process with the sensory cells acting as mere receptors. The high sensitivity and sharp tuning of the auditory apparatus are very much dependant on the active mechanical behavior of the outer hair cells, acting as effector cells.

  16. Star Power: Providing for the Gifted & Talented. Module 5. Enrichment Activities for the Gifted/Talented.

    ERIC Educational Resources Information Center

    Mallis, Jackie; Gilman, Sharlene

    The document presents Module 5, enrichment activities for the gifted/talented, of the Star Power modules developed for school personnel who have an interest in or a need to explore the area of gifted and talented education. It is explained in an introductory section that the modules can be used for independent study, for small group interaction,…

  17. Home Learning Activities Designed to Provide Educational Experiences for Children and Parents. Part 1.

    ERIC Educational Resources Information Center

    Seay, Shirley H.; Brown, Brenda

    This manual, Part 1 of a two-volume series, is a compilation of instructional tasks designed to be used in the home by parents with their children. These home learning activities are one component of the Florida Model of Follow Through Programs. Each instructional task is designed for use in the home by a Parent Educator (P.E.) who has already…

  18. Effects of providing a nutrition education program for teenagers: dietary and physical activity patterns.

    PubMed

    Tse, Mimi M Y; Yuen, Dorothy T W

    2009-06-01

    This study enhanced nutritional knowledge in an education program and encouraged healthy dietary habits and regular physical activity among teenagers. A total of 203 adolescents from a secondary school in Hong Kong took part in the study. Their Body Mass Index, dietary habits, and physical exercise pattern were recorded and examined before and after the health education program. The prevalence of overweight and obesity, together with the fat composition, were high among the participants before the nutrition education program. There was a marked gain in knowledge upon its completion. A follow-up action conducted 3 months later revealed positive outcomes in relation to the diet and physical activity level. The teenagers were able to take control of their health and requested the tuck shop to sell more healthy food and reduce the supply of unhealthy items. The educational initiatives in dietary habits and physical activities proved to be effective in encouraging the teenagers to eat more healthily and to adopt an active lifestyle.

  19. Time-driven activity-based costing of multivessel coronary artery bypass grafting across national boundaries to identify improvement opportunities: study protocol

    PubMed Central

    Erhun, F; Mistry, B; Platchek, T; Milstein, A; Narayanan, V G; Kaplan, R S

    2015-01-01

    Introduction Coronary artery bypass graft (CABG) surgery is a well-established, commonly performed treatment for coronary artery disease—a disease that affects over 10% of US adults and is a major cause of morbidity and mortality. In 2005, the mean cost for a CABG procedure among Medicare beneficiaries in the USA was $32 201±$23 059. The same operation reportedly costs less than $2000 to produce in India. The goals of the proposed study are to (1) identify the difference in the costs incurred to perform CABG surgery by three Joint Commission accredited hospitals with reputations for high quality and efficiency and (2) characterise the opportunity to reduce the cost of performing CABG surgery. Methods and analysis We use time-driven activity-based costing (TDABC) to quantify the hospitals’ costs of producing elective, multivessel CABG. TDABC estimates the costs of a given clinical service by combining information about the process of patient care delivery (specifically, the time and quantity of labour and non-labour resources utilised to perform each activity) with the unit cost of each resource used to provide the care. Resource utilisation was estimated by constructing CABG process maps for each site based on observation of care and staff interviews. Unit costs were calculated as a capacity cost rate, measured as a $/min, for each resource consumed in CABG production. Multiplying together the unit costs and resource quantities and summing across all resources used will produce the average cost of CABG production at each site. We will conclude by conducting a variance analysis of labour costs to reveal opportunities to bend the cost curve for CABG production in the USA. Ethics and dissemination All our methods were exempted from review by the Stanford Institutional Review Board. Results will be published in peer-reviewed journals and presented at scientific meetings. PMID:26307621

  20. Ambivalence about smoking and cue-elicited neural activity in quitting-motivated smokers faced with an opportunity to smoke.

    PubMed

    Wilson, Stephen J; Creswell, Kasey G; Sayette, Michael A; Fiez, Julie A

    2013-02-01

    Many cigarette smokers appear to experience ambivalence about smoking, defined as the simultaneous co-occurrence of a strong desire to smoke and a strong wish to quit smoking. Research suggests that this ambivalence about smoking affects how smokers respond to cigarette-related stimuli, but many important questions remain about precisely how smoking ambivalence influences cognitive and affective processing during cigarette cue exposure. We used functional magnetic resonance imaging (fMRI) to address this knowledge gap by examining the relation between self-reported ambivalence about smoking and cue-reactivity in quitting-motivated smokers presented with an opportunity to smoke. Eighty-two quitting-motivated cigarette smokers completed a measure assessing their ambivalence about smoking. Subsequently, participants initiated an attempt to quit smoking and underwent an fMRI session, during which they were asked to hold and view a cigarette. Consistent with hypotheses, results indicated that self-reported smoking ambivalence was negatively correlated with cigarette-related activation in brain areas linked to reward-related processing, motivation, and attention (i.e., rostral anterior cingulate and medial prefrontal cortex, caudate nucleus, visual cortex). Self-reported ambivalence was not, however, correlated with activation in brain regions related to conflict processing. This pattern of results is discussed with respect to the process of change for those attempting to quit smoking.

  1. School Involvement Leave: Providing Leave for Parental Involvement in School Activities. Policy Briefing Series. Issue 18

    ERIC Educational Resources Information Center

    Curlew, Mary; Weber, Julie

    2009-01-01

    One of the most important factors in school performance is parental involvement. However, many parents do not have the flexibility in their work schedules or the leave policies necessary to attend school functions. As a result, legislators are creating policies to address this issue. School involvement leave policies provide parents with…

  2. 75 FR 9903 - Agency Information Collection Activities; Proposed Collection; Comment Request; Service; Provider...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... information set forth in this document. With respect to the following collection of information, AoA invites... information technology. The Administration on Aging collects annual program data at the state level and has... Aging Network that administers and implements OAA programs, the Local Service Providers are...

  3. Providing Access to Local Government Information: The Nature of Public Library Activity.

    ERIC Educational Resources Information Center

    Durrance, Joan C.

    1988-01-01

    Describes a survey of public libraries that examined problems associated with access to local government information. Findings are reported on the nature of requests received, the types of responses given and sources used, and reasons given by librarians for providing access to local government information. (14 notes with references) (CLB)

  4. SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.

    PubMed

    Siu, Fai Y; Spanggord, Richard J; Doudna, Jennifer A

    2007-02-01

    The signal recognition particle (SRP) cotranslationally targets proteins to cell membranes by coordinated binding and release of ribosome-associated nascent polypeptides and a membrane-associated SRP receptor. GTP uptake and hydrolysis by the SRP-receptor complex govern this targeting cycle. Because no GTPase-activating proteins (GAPs) are known for the SRP and SRP receptor GTPases, however, it has been unclear whether and how GTP hydrolysis is stimulated during protein trafficking in vivo. Using both biochemical and genetic experiments, we show here that SRP RNA enhances GTPase activity of the SRP-receptor complex above a critical threshold required for cell viability. Furthermore, this stimulation is a property of the SRP RNA tetraloop. SRP RNA tetraloop mutants that confer defective growth phenotypes can assemble into SRP-receptor complexes, but fail to stimulate GTP hydrolysis in these complexes in vitro. Tethered hydroxyl radical probing data reveal that specific positioning of the RNA tetraloop within the SRP-receptor complex is required to stimulate GTPase activity to a level sufficient to support cell growth. These results explain why no external GAP is needed and why the phylogenetically conserved SRP RNA tetraloop is required in vivo.

  5. Passive Reactive Berm (PRBerm) to Provide Low Maintenance Lead Containment at Active Small Arms Firing Ranges

    DTIC Science & Technology

    2012-01-01

    biological oxygen demand Ca calcium CAFB Charleston Air Force Base Cd cadmium CEC cation exchange capacity COTS commercial off-the-shelf Cr...Pb salts . This technology application is known as a Passive Reactive Berm (PRBerm™). The purpose of the technology demonstration is to provide...precipitation of Pb salts (e.g., carbonates, sulfates, sulfides, and phosphates). Generally, the mobility of dissolved Pb is controlled by pH

  6. The role of provider-patient communication and trust in online sources in Internet use for health-related activities.

    PubMed

    Hou, Jiran; Shim, Minsun

    2010-01-01

    Provider-patient communication is an important factor influencing patients' satisfaction and health outcomes. This study draws upon the uses and gratification theory to examine how individuals' perception of communication with healthcare providers is associated with their Internet use for health-related activities. Using the data from the 2007 Health Information National Trends Survey (HINTS), we found that as individuals perceived their communication with providers to be less patient-centered, they were more likely to engage in various types of online health activities, such as using websites for healthy lifestyles, searching for healthcare providers, and seeking health information. Trust in online health information was also found to be a significant predictor of online health activities. The results of this study emphasized the important role of provider-patient communication in motivating individuals to turn to the Internet for health purposes.

  7. Space Educational Opportunities and Outreach Activities at the Dawn of the 21st Century. A European Students Perspective

    NASA Astrophysics Data System (ADS)

    Ferretti, S.; Robinson, D.; Manfletti, C.; Amadori, K.; Boccalatte, A.; Alessandrini, M.; Bedogna, P.; Corradi, P.; Marcuccio, M.

    2002-01-01

    Taking part in space activities and participating in the development and growth of space project has now become an undeniable reality. Thanks to academic institutions and outreach activities space enthusiasts can engage in numerous and diverse yet unique opportunities. The ESA Outreach Office sees students of every background taking part in its activities. This unique mixture of students of diverse nationalities enthusiastically co-operating ensures the program's interdisciplinarity. The added value of such an environment to the programs is significant and must not be forgotten. The friendship that blossom, and lose with which cultural and language barriers are overcome during the time spent working on the projects offered to university student and young professionals are invaluable. The purpose of this abstract is to give our perspective to the space community and to the general public on the importance of developing a space culture. The academic value of the space research projects mainly in which the authors have participated, the importance of such projects for the future of European relations and personal and social development through experience of international teams are topics that will be addressed. The activities discussed are : Attending sessions of congresses around the world, making contacts of major companies and players in the space sector, dealing of topics such as space engineering, policy and law, life sciences, business and finance, satellite applications, the exhilaration of floating in zero-g, the interdisciplinary, international and intercultural approach, the chance of quickly learning about many new concepts are just some of the marvellous experiences and opportunities that these programs offer. Reaching out to the general public is the second purpose of these unique activities.Images, photos and reports can seep into every house thanks to the great instrument that is the media, thus informing almost everyone about the activities and

  8. New Hyperekplexia Mutations Provide Insight into Glycine Receptor Assembly, Trafficking, and Activation Mechanisms*

    PubMed Central

    Bode, Anna; Wood, Sian-Elin; Mullins, Jonathan G. L.; Keramidas, Angelo; Cushion, Thomas D.; Thomas, Rhys H.; Pickrell, William O.; Drew, Cheney J. G.; Masri, Amira; Jones, Elizabeth A.; Vassallo, Grace; Born, Alfred P.; Alehan, Fusun; Aharoni, Sharon; Bannasch, Gerald; Bartsch, Marius; Kara, Bulent; Krause, Amanda; Karam, Elie G.; Matta, Stephanie; Jain, Vivek; Mandel, Hanna; Freilinger, Michael; Graham, Gail E.; Hobson, Emma; Chatfield, Sue; Vincent-Delorme, Catherine; Rahme, Jubran E.; Afawi, Zaid; Berkovic, Samuel F.; Howell, Owain W.; Vanbellinghen, Jean-François; Rees, Mark I.; Chung, Seo-Kyung; Lynch, Joseph W.

    2013-01-01

    Hyperekplexia is a syndrome of readily provoked startle responses, alongside episodic and generalized hypertonia, that presents within the first month of life. Inhibitory glycine receptors are pentameric ligand-gated ion channels with a definitive and clinically well stratified linkage to hyperekplexia. Most hyperekplexia cases are caused by mutations in the α1 subunit of the human glycine receptor (hGlyR) gene (GLRA1). Here we analyzed 68 new unrelated hyperekplexia probands for GLRA1 mutations and identified 19 mutations, of which 9 were novel. Electrophysiological analysis demonstrated that the dominant mutations p.Q226E, p.V280M, and p.R414H induced spontaneous channel activity, indicating that this is a recurring mechanism in hGlyR pathophysiology. p.Q226E, at the top of TM1, most likely induced tonic activation via an enhanced electrostatic attraction to p.R271 at the top of TM2, suggesting a structural mechanism for channel activation. Receptors incorporating p.P230S (which is heterozygous with p.R65W) desensitized much faster than wild type receptors and represent a new TM1 site capable of modulating desensitization. The recessive mutations p.R72C, p.R218W, p.L291P, p.D388A, and p.E375X precluded cell surface expression unless co-expressed with α1 wild type subunits. The recessive p.E375X mutation resulted in subunit truncation upstream of the TM4 domain. Surprisingly, on the basis of three independent assays, we were able to infer that p.E375X truncated subunits are incorporated into functional hGlyRs together with unmutated α1 or α1 plus β subunits. These aberrant receptors exhibit significantly reduced glycine sensitivity. To our knowledge, this is the first suggestion that subunits lacking TM4 domains might be incorporated into functional pentameric ligand-gated ion channel receptors. PMID:24108130

  9. Communication between Asian American Adolescents and Health Care Providers about Sexual Activity, Sexually Transmitted Infections, and Pregnancy Prevention

    ERIC Educational Resources Information Center

    Zhao, Jessie; Lau, May; Vermette, David; Liang, David; Flores, Glenn

    2017-01-01

    Asian American adolescents have been reported to have the lowest amount of communication with health care providers regarding sexual health topics (sexual activity, contraception, sexually transmitted infections, and pregnancy prevention). This study identified Asian American adolescents' attitudes/beliefs regarding how health care providers can…

  10. Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control

    PubMed Central

    Malnati, Mauro S.; Ugolotti, Elisabetta; Monti, Maria Cristina; Battista, Davide De; Vanni, Irene; Bordo, Domenico; Sironi, Francesca; Larghero, Patrizia; Marco, Eddi Di; Biswas, Priscilla; Poli, Guido; Vicenzi, Elisa; Riva, Agostino; Tarkowski, Maciej; Tambussi, Giuseppe; Nozza, Silvia; Tripodi, Gino; Marras, Francesco; Maria, Andrea De; Pistorio, Angela; Biassoni, Roberto

    2017-01-01

    Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia. PMID:28211903

  11. The Cost of Dengue Vector Control Activities in Malaysia by Different Service Providers.

    PubMed

    Packierisamy, P Raviwharmman; Ng, Chiu-Wan; Dahlui, Maznah; Venugopalan, B; Halasa, Yara A; Shepard, Donald S

    2015-11-01

    We examined variations in dengue vector control costs and resource consumption between the District Health Departments (DHDs) and Local Authorities (LAs) to assist informed decision making as to the future roles of these agencies in the delivery of dengue vector control services in Malaysia. Data were collected from the vector control units of DHDs and LAs in 8 selected districts. We captured costs and resource consumption in 2010 for premise inspection for mosquito breeding sites, fogging to destroy adult mosquitoes and larviciding of potential breeding sites. Overall, DHDs spent US$5.62 million or US$679 per case and LAs spent US$2.61 million or US$499 per case. The highest expenditure for both agencies was for fogging, 51.0% and 45.8% of costs for DHDs and LAs, respectively. The DHDs had higher resource costs for human personnel, vehicles, pesticides, and equipment. The findings provide some evidence to rationalize delivery of dengue vector control services in Malaysia.

  12. Elder Care for Alzheimer's: Choosing a Provider

    MedlinePlus

    ... provide an opportunity for your loved one with Alzheimer's to receive assistance and therapeutic activities in a group setting. Being a full- ... t wander off Counseling Activities, such as art, music, recreation or support ... care Medication management Meals and nutrition Personal ...

  13. From a fuel supplier to an active participant: Shell's view of the opportunities offered by a changing power market

    SciTech Connect

    Nyhan, J.

    1998-07-01

    In the last 10 years, the power generation market has seen radical changes. The coming years will see yet more change. Although the pace of change may be uneven across Europe, it is clear that the old reference points for the power generation market are no longer valid. Along with other market players, Shell has re-evaluated the role it wishes to play in the power generation market. Although it has long operated large generation capacity on its own sites, Shell's role has been that of a fuel supplier to monopoly power generation and distribution organizations, which were largely state controlled . Privatization and liberalization have been followed by changing market structures tending to push risk towards the producer. This evolution presents challenges for the normal IPP structure, where market risk is transferred and offers an opportunity for the active participation of the fuel supplier in meeting these challenges. In 1996, Shell decided to embrace the changes in power generation market. Already, significant steps have been taken in markets in Asia, Latin America and in Europe. The differing requirements of each of these markets means there are no standard solutions and requires Shell to devise flexible frameworks which meet the customer's needs. Shell is bringing its significant strengths to the power generation market and looks forward to participating on a world wide scale in the industry at this exciting phase in its development.

  14. Vein networks in hydrothermal systems provide constraints for the monitoring of active volcanoes.

    PubMed

    Cucci, Luigi; Di Luccio, Francesca; Esposito, Alessandra; Ventura, Guido

    2017-12-01

    Vein networks affect the hydrothermal systems of many volcanoes, and variations in their arrangement may precede hydrothermal and volcanic eruptions. However, the long-term evolution of vein networks is often unknown because data are lacking. We analyze two gypsum-filled vein networks affecting the hydrothermal field of the active Lipari volcanic Island (Italy) to reconstruct the dynamics of the hydrothermal processes. The older network (E1) consists of sub-vertical, N-S striking veins; the younger network (E2) consists of veins without a preferred strike and dip. E2 veins have larger aperture/length, fracture density, dilatancy, and finite extension than E1. The fluid overpressure of E2 is larger than that of E1 veins, whereas the hydraulic conductance is lower. The larger number of fracture intersections in E2 slows down the fluid movement, and favors fluid interference effects and pressurization. Depths of the E1 and E2 hydrothermal sources are 0.8 km and 4.6 km, respectively. The decrease in the fluid flux, depth of the hydrothermal source, and the pressurization increase in E2 are likely associated to a magma reservoir. The decrease of fluid discharge in hydrothermal fields may reflect pressurization at depth potentially preceding hydrothermal explosions. This has significant implications for the long-term monitoring strategy of volcanoes.

  15. A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus.

    PubMed

    Sasaki, Keisuke; Tungtrakoolsub, Pullop; Morozumi, Takeya; Uenishi, Hirohide; Kawahara, Manabu; Watanabe, Tomomasa

    2014-01-01

    The objective was to determine if single nucleotide polymorphisms (SNPs) in porcine MX2 gene affect its antiviral potential. MX proteins are known to suppress the multiplication of several viruses, including influenza virus and vesicular stomatitis virus (VSV). In domestic animals possessing highly polymorphic genome, our previous research indicated that a specific SNP in chicken Mx gene was responsible for its antiviral function. However, there still has been no information about SNPs in porcine MX2 gene. In this study, we first conducted polymorphism analysis in 17 pigs of MX2 gene derived from seven breeds. Consequently, a total of 30 SNPs, of which 11 were deduced to cause amino acid variations, were detected, suggesting that the porcine MX2 is very polymorphic. Next, we classified MX2 into eight alleles (A1-A8) and subsequently carried out infectious experiments with recombinant VSVΔG*-G to each allele. In A1-A5 and A8, position 514 amino acid (514 aa) of MX2 was glycine (Gly), which did not inhibit VSV multiplication, whereas in A6 and A7, 514 aa was arginine (Arg), which exhibited the antiviral ability against VSV. These results demonstrate that a SNP at 514 aa (Gly-Arg) of porcine MX2 plays a pivotal role in the antiviral activity as well as that at 631 aa of chicken Mx.

  16. Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones

    PubMed Central

    Döhrmann, Simon; LaRock, Christopher N.; Anderson, Ericka L.; Cole, Jason N.; Ryali, Brinda; Stewart, Chelsea; Nonejuie, Poochit; Pogliano, Joe; Corriden, Ross; Ghosh, Partho; Nizet, Victor

    2017-01-01

    Histones are essential elements of chromatin structure and gene regulation in eukaryotes. An unexpected attribute of these nuclear proteins is their antimicrobial activity. A framework for histone release and function in host defense in vivo was revealed with the discovery of neutrophil extracellular traps, a specialized cell death process in which DNA-based structures containing histones are extruded to ensnare and kill bacteria. Investigating the susceptibility of various Gram-positive pathogens to histones, we found high-level resistance by one leading human pathogen, group A Streptococcus (GAS). A screen of isogenic mutants revealed that the highly surface-expressed M1 protein, a classical GAS virulence factor, was required for high-level histone resistance. Biochemical and microscopic analyses revealed that the N-terminal domain of M1 protein binds and inactivates histones before they reach their cell wall target of action. This finding illustrates a new pathogenic function for this classic GAS virulence factor, and highlights a potential innate immune evasion strategy that may be employed by other bacterial pathogens. PMID:28220899

  17. Does the survivorship of activated resting stages in toxic environments provide cues for ballast water treatment?

    PubMed

    Alekseev, Victor; Makrushin, Andrey; Hwang, Jiang-Shiou

    2010-01-01

    The toxic effects of three inorganic metals (Cu, Cr, Hg), three organic (phenol, formalin, ammonium) chemicals, ozone-enriched water and peroxides (H2O2) on embryonic development were tested in 8 species from the Porifera, Bryozoa and Crustacea. Toxicants with lower molecular weight showed stronger negative impacts on post-diapause embryos than chemicals with higher molecular weight if related to the toxicity of the chemicals to active adult stages. Only few embryos of the cladoceran Moina macrocopa and none of the cladoceran Wlassicsia pannonica treated with peroxides at concentration 0.3% developed further. Ozone-enriched water had no significant effect on post-diapause embryonic development in cladocerans. Ammonium (the product of NH4OH dissociation) in concentration 100 mg/l and higher killed all embryos of M. macrocopa inside protective membranes. Peroxides and ammonium are suggested for the purification of ship ballast waters as effective, non-expensive and non-persistent toxic chemicals. Resting stages of invertebrates including at least Crustaceans, Porifera and Bryozoa seem to allow not only dispersal among toxic industrial environments such as ship ballast compartments, but may also endure serious pollution events common in seaports and estuaries. Artemia cysts due to their strong protection against different toxic substances are recommended as a model for studies of toxic effects in diapausing stages in polluted estuaries and marine environments.

  18. Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

    PubMed Central

    Sun, Meiyan; Deng, Bin; Zhao, Xiaoyong; Gao, Changjun; Yang, Lu; Zhao, Hui; Yu, Daihua; Zhang, Feng; Xu, Lixian; Chen, Lei; Sun, Xude

    2015-01-01

    Excessive microglial activation often contributes to inflammation-mediated neurotoxicity in the ischemic penumbra during the acute stage of ischemic stroke. Toll-like receptor 4 (TLR4) has been reported to induce microglial activation via the NF-κB pathway. Isoflurane preconditioning (IP) can provide neuroprotection and inhibit microglial activation. In this study, we investigated the roles of the TLR4 signalling pathway in IP to exert neuroprotection following ischemic stroke in vivo and in vitro. The results showed that 2% IP alleviated neurological deficits, reduced the infarct volume, attenuated apoptosis and weakened microglial activation in the ischemic penumbra. Furthermore, IP down-regulated the expression of HSP 60, TLR4 and MyD88 and up-regulated inhibitor of IκB-α expression compared with I/R group in vivo. In vitro, 2% IP and a specific inhibitor of TLR4, CLI-095, down-regulated the expression of TLR4, MyD88, IL-1β, TNF-α and Bax, and up-regulated IκB-α and Bcl-2 expression compared with OGD group. Moreover, IP and CLI-095 attenuated microglial activation-induced neuronal apoptosis, and overexpression of the TLR4 gene reversed the neuroprotective effects of IP. In conclusion, IP provided neuroprotection by regulating TLR4 expression directly, alleviating microglial activation and neuroinflammation. Thus, inhibiting the activation of microglial activation via TLR4 may be a new avenue for stroke treatment. PMID:26086415

  19. Opportunity's Travels

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This overview map made from Mars Orbiter camera images illustrates the path that the Mars Exploration Rover Opportunity has taken from its first sol on the red planet through its 87th sol. After thoroughly examining its 'Eagle Crater' landing-site, the rover moved onto the plains of Meridiani Planum, stopping to examine a curious trough and a target within it called 'Anatolia.' Following that, Opportunity approached and remotely studied the rocky dish called 'Fram Crater.' As of its 91st sol (April 26, 2004), the rover sits 160 meters (about 525 feet) from the rim of 'Endurance Crater.'

  20. Opportunity Rocks!

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This high-resolution image captured by the Mars Exploration Rover Opportunity's panoramic camera shows in superb detail a portion of the puzzling rock outcropping that scientists are eagerly planning to investigate. Presently, Opportunity is on its lander facing northeast; the outcropping lies to the northwest. These layered rocks measure only 10 centimeters (4 inches) tall and are thought to be either volcanic ash deposits or sediments carried by water or wind. The small rock in the center is about the size of a golf ball.

  1. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

    PubMed

    Filbin, Mariella Gruber; Dabral, Sukriti K; Pazyra-Murphy, Maria F; Ramkissoon, Shakti; Kung, Andrew L; Pak, Ekaterina; Chung, Jarom; Theisen, Matthew A; Sun, Yanping; Franchetti, Yoko; Sun, Yu; Shulman, David S; Redjal, Navid; Tabak, Barbara; Beroukhim, Rameen; Wang, Qi; Zhao, Jean; Dorsch, Marion; Buonamici, Silvia; Ligon, Keith L; Kelleher, Joseph F; Segal, Rosalind A

    2013-11-01

    In glioblastoma, phosphatidylinositol 3-kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor phosphatase and tensin homolog (PTEN). However, it is not known whether inhibiting PI3K represents a selective and effective approach for treatment. We interrogated large databases and found that sonic hedgehog (SHH) signaling is activated in PTEN-deficient glioblastoma. We demonstrate that the SHH and PI3K pathways synergize to promote tumor growth and viability in human PTEN-deficient glioblastomas. A combination of PI3K and SHH signaling inhibitors not only suppressed the activation of both pathways but also abrogated S6 kinase (S6K) signaling. Accordingly, targeting both pathways simultaneously resulted in mitotic catastrophe and tumor apoptosis and markedly reduced the growth of PTEN-deficient glioblastomas in vitro and in vivo. The drugs tested here appear to be safe in humans; therefore, this combination may provide a new targeted treatment for glioblastoma.

  2. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

    PubMed Central

    Gruber-Filbin, Mariella; Dabral, Sukriti K.; Pazyra-Murphy, Maria F.; Ramkissoon, Shakti; Kung, Andrew L.; Pak, Ekaterina; Chung, Jarom; Theisen, Matthew A.; Sun, Yanping; Franchetti, Yoko; Sun, Yu; Shulman, David S.; Redjal, Navid; Tabak, Barbara; Beroukhim, Rameen; Wang, Qi; Zhao, Jean; Dorsch, Marion; Buonamici, Silvia; Ligon, Keith L.; Kelleher, Joseph F.; Segal, Rosalind A.

    2014-01-01

    In glioblastoma, PI3kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor PTEN1. However, it is not known whether inhibiting PI3K represents a selective and effective approach for treatment. Here we interrogate large databases and find that Shh signaling is activated in PTEN-deficient glioblastoma. We demonstrate that Shh and PI3K pathways synergize to promote tumor growth and viability in human PTEN-deficient glioblastomas. A combination of PI3K and Shh signaling inhibitors not only suppresses activation of both pathways, but also abrogates S6kinase signaling. Accordingly, simultaneously targeting both pathways results in mitotic catastrophe and tumor apoptosis, and dramatically reduces growth of PTEN-deficient glioblastomas in vitro and in vivo. The drugs tested here appear safe in humans; therefore this combination may provide new targeted treatment for glioblastoma. PMID:24076665

  3. Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providers.

    PubMed

    Roston, Thomas M; De Souza, Astrid M; Sandor, George G S; Sanatani, Shubhayan; Potts, James E

    2013-08-01

    Determining safe levels of physical activity for children and adolescents with electrophysiologic and structural congenital heart disease is a challenging clinical problem. The body of evidence for making these recommendations is limited and likely based on expert opinion, medicolegal concerns, and perceived risks of sudden cardiac death (SCD) with activity. The Bethesda Conference has established consensus guidelines for determining the eligibility of athletes with cardiovascular abnormalities for competitive sports and their disqualification from them. However, literature on guidelines for noncompetitive physical activity is not available. A survey was designed to determine practice patterns for patients with electrophysiologic and structural congenital heart disease. Between July 2011 and December 2011, approximately 350 health care providers working with this group of patients were recruited by email or while attending professional meetings. The survey received 81 responses, primarily from pediatric cardiologists (70 %). The findings indicate that the majority of Canadian cardiac care providers surveyed are only partially implementing current recommendations. Areas of variance included physical activity recommendations for hypertrophic cardiomyopathy, long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, and heart transplantation, among others. The development of comprehensive consensus guidelines for activity recommendations was supported by 96 % of the respondents. The heterogeneity of responses may be attributable to conflicting and poorly evidenced information in the literature, a lack of emphasis on recreational activity, an entrenched tendency toward bed rest in the cardiology community, and a lack of awareness by cardiac care providers regarding the actual risk associated with physical activity in electrophysiologic and structural congenital heart disease. A balanced discussion is required in considering both the significant benefit of

  4. Enhancing Recognition of High Quality, Functional IFSP Outcomes: A Training Activity for Infant and Toddler Service Providers

    ERIC Educational Resources Information Center

    Lucas, Anne; Gillaspy, Kathi; Peters, Mary Louise; Hurth, Joicey

    2014-01-01

    This training activity was created to support participants' understanding of the criteria needed to develop and write high quality, participation-based Individualized Family Service Plan (IFSP) outcomes. The term "functional" is often used to describe what outcomes ought to be, yet many providers struggle to define what makes an outcome…

  5. A Context-Aware Ubiquitous Learning Approach for Providing Instant Learning Support in Personal Computer Assembly Activities

    ERIC Educational Resources Information Center

    Hsu, Ching-Kun; Hwang, Gwo-Jen

    2014-01-01

    Personal computer assembly courses have been recognized as being essential in helping students understand computer structure as well as the functionality of each computer component. In this study, a context-aware ubiquitous learning approach is proposed for providing instant assistance to individual students in the learning activity of a…

  6. China takes an active role in combating an Ebola outbreak: On-site observations and reflections from a Chinese healthcare provider.

    PubMed

    Lu, Hongzhou

    2015-11-01

    As one of the active participants in the global fight against the 2014 outbreak of Ebola virus disease (EVD) in West Africa, China supplied many resources, including medical experts and scientists as well as medical supplies, to the affected countries. A member of the first contingent of Chinese public health experts who worked in Sierra Leone for 65 days, I am pleased to have this opportunity to review the major work done by our team to help deal with the Ebola epidemic in Sierra Leone. This is the first time that a Chinese public health training team has worked in West Africa. The team provides trainings for people from local communities in an effort to encourage local residents to get involved in the war against Ebola. However, the implementation of active measures against Ebola in West Africa was hampered somewhat by certain drawbacks in the area in terms of the health system, the shortage of medical resources, the high illiteracy rate, unhealthy lifestyles, and traditional funeral rites. All of these aspects need to be gradually improved in the aftermath of Ebola, and I believe that this is an area in which the Chinese public health system can play an important role.

  7. [Active surveillance of adverse drug reaction in the era of big data: challenge and opportunity for control selection].

    PubMed

    Wang, S F; Zhan, S Y

    2016-07-01

    Electronic healthcare databases have become an important source for active surveillance of drug safety in the era of big data. The traditional epidemiology research designs are needed to confirm the association between drug use and adverse events based on these datasets, and the selection of the comparative control is essential to each design. This article aims to explain the principle and application of each type of control selection, introduce the methods and parameters for method comparison, and describe the latest achievements in the batch processing of control selection, which would provide important methodological reference for the use of electronic healthcare databases to conduct post-marketing drug safety surveillance in China.

  8. Investigative Homework with Apples: An Opportunity for Primary-School Students to Learn Actively the Relationship between Density and Flotation

    ERIC Educational Resources Information Center

    Radovanovic, Jelena; Sliško, Josip

    2014-01-01

    This paper describes investigative homework with apples, aiming to contribute to the primary-school students' understanding of density and conditions leading to floating and sinking. The assignment represents an opportunity for individual autonomous learning of physics and adoption of established scientific concepts through practical activities…

  9. 75 FR 5804 - Small and Medium-Sized Enterprises: U.S. and EU Export Activities, and Barriers and Opportunities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... to the Commission should contact the Office of the Secretary at 202-205-2000. Background Information.... SMEs face in their efforts to export. The strategies that SMEs have adopted to address or overcome those constraints. The benefits to SMEs of increased export opportunities from free trade agreements...

  10. Health/Service Providers' Perspectives on Barriers to Healthy Weight Gain and Physical Activity in Pregnant, Urban First Nations Women.

    PubMed

    Darroch, Francine E; Giles, Audrey R

    2016-01-01

    The purpose of this article is to examine health/service providers' perspectives of barriers to healthy weight gain and physical activity for urban, pregnant First Nations women in Ottawa, Canada. Through the use of semi-structured interviews, we explored 15 health/service providers' perspectives on the complex barriers their clients face. By using a postcolonial feminist lens and a social determinants of health framework, we identified three social determinants of health that the health/service providers believed to have the greatest influence on their clients' weight gain and physical activity during pregnancy: poverty, education, and colonialism. Our findings are then contextualized within existing Statistics Canada and the Ottawa Neighbourhood Study data. We found that health/service providers are in a position to challenge colonial relations of power. We conclude by urging health/service providers, researchers, and policymakers alike to take into consideration the ways in which these social determinants of health and their often synergistic effects affect urban First Nations women during pregnancy.

  11. Opportunity's Path

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This Long Term Planning graphic was created from a mosaic of navigation camera images overlain by a polar coordinate grid with the center point as Opportunity's original landing site. The blue dots represent the rover position at various locations.

    The red dots represent the center points of the target areas for the instruments on the rover mast (the panoramic camera and miniature thermal emission spectrometer). Opportunity visited Stone Mountain on Feb. 5. Stone Mountain was named after the southernmost point of the Appalachian Mountains outside of Atlanta, Ga. On Earth, Stone Mountain is the last big mountain before the Piedmont flatlands, and on Mars, Stone Mountain is at one end of Opportunity Ledge. El Capitan is a target of interest on Mars named after the second highest peak in Texas in Guadaloupe National Park, which is one of the most visited outcrops in the United States by geologists. It has been a training ground for students and professional geologists to understand what the layering means in relation to the formation of Earth, and scientists will study this prominent point of Opportunity Ledge to understand what the layering means on Mars.

    The yellow lines show the midpoint where the panoramic camera has swept and will sweep a 120-degree area from the three waypoints on the tour of the outcrop. Imagine a fan-shaped wedge from left to right of the yellow line.

    The white contour lines are one meter apart, and each drive has been roughly about 2-3 meters in length over the last few sols. The large white blocks are dropouts in the navigation camera data.

    Opportunity is driving along and taking a photographic panorama of the entire outcrop. Scientists will stitch together these images and use the new mosaic as a 'base map' to decide on geology targets of interest for a more detailed study of the outcrop using the instruments on the robotic arm. Once scientists choose their targets of interest, they plan to study the outcrop for roughly five to

  12. Young, Healthy Subjects Can Reduce the Activity of Calf Muscles When Provided with EMG Biofeedback in Upright Stance

    PubMed Central

    Vieira, Taian M.; Baudry, Stéphane; Botter, Alberto

    2016-01-01

    Recent evidence suggests the minimization of muscular effort rather than of the size of bodily sway may be the primary, nervous system goal when regulating the human, standing posture. Different programs have been proposed for balance training; none however has been focused on the activation of postural muscles during standing. In this study we investigated the possibility of minimizing the activation of the calf muscles during standing through biofeedback. By providing subjects with an audio signal that varied in amplitude and frequency with the amplitude of surface electromyograms (EMG) recorded from different regions of the gastrocnemius and soleus muscles, we expected them to be able to minimize the level of muscle activation during standing without increasing the excursion of the center of pressure (CoP). CoP data and surface EMG from gastrocnemii, soleus and tibialis anterior muscles were obtained from 10 healthy participants while standing at ease and while standing with EMG biofeedback. Four sensitivities were used to test subjects' responsiveness to the EMG biofeedback. Compared with standing at ease, the two most sensitive feedback conditions induced a decrease in plantar flexor activity (~15%; P < 0.05) and an increase in tibialis anterior EMG (~10%; P < 0.05). Furthermore, CoP mean position significantly shifted backward (~30 mm). In contrast, the use of less sensitive EMG biofeedback resulted in a significant decrease in EMG activity of ankle plantar flexors with a marginal increase in TA activity compared with standing at ease. These changes were not accompanied by greater CoP displacements or significant changes in mean CoP position. Key results revealed subjects were able to keep standing stability while reducing the activity of gastrocnemius and soleus without loading their tibialis anterior muscle when standing with EMG biofeedback. These results may therefore posit the basis for the development of training protocols aimed at assisting subjects in

  13. Federal Funding Opportunities to Support the P-20W Data Pipeline. Federal Spotlight

    ERIC Educational Resources Information Center

    Data Quality Campaign, 2014

    2014-01-01

    This publication provides an overview of the current federal opportunities to help states advance their data-related activities. Although not exhaustive, this list provides a starting point for federal policymakers to support states' work in this area.

  14. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.

    PubMed

    Molitor, Christian; Mauracher, Stephan Gerhard; Rompel, Annette

    2016-03-29

    Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs). Tyrosinases catalyze theo-hydroxylation and oxidation of phenolic compounds, whereas catechol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation of o-diphenolic compounds. Aurone synthase from Coreopsis grandiflora (AUS1) is a specialized plant PPO involved in the anabolic pathway of aurones. We present, to our knowledge, the first crystal structures of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding histidine. Analysis of the latent proenzyme's interface between the shielding C-terminal domain and the main core provides insights into its activation mechanisms. As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzyme is classified as a catechol oxidase. However, AUS1 showed hydroxylase activity toward its natural substrate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptance of common tyrosinase substrates. Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs. Molecular dynamics simulations of docked substrate-enzyme complexes were performed, and a key residue was identified that influences the plant PPO's acceptance or rejection of tyramine. Based on the evidenced hydroxylase activity and the interactions of specific residues with the substrates during the molecular dynamics simulations, a novel catalytic reaction mechanism for plant PPOs is proposed. The presented results strongly suggest that the physiological role of plant catechol oxidases were previously underestimated, as they might hydroxylate their--so far unknown--natural substrates in vivo.

  15. Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases

    PubMed Central

    Molitor, Christian; Mauracher, Stephan Gerhard

    2016-01-01

    Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs). Tyrosinases catalyze the o-hydroxylation and oxidation of phenolic compounds, whereas catechol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation of o-diphenolic compounds. Aurone synthase from Coreopsis grandiflora (AUS1) is a specialized plant PPO involved in the anabolic pathway of aurones. We present, to our knowledge, the first crystal structures of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding histidine. Analysis of the latent proenzyme’s interface between the shielding C-terminal domain and the main core provides insights into its activation mechanisms. As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzyme is classified as a catechol oxidase. However, AUS1 showed hydroxylase activity toward its natural substrate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptance of common tyrosinase substrates. Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs. Molecular dynamics simulations of docked substrate–enzyme complexes were performed, and a key residue was identified that influences the plant PPO’s acceptance or rejection of tyramine. Based on the evidenced hydroxylase activity and the interactions of specific residues with the substrates during the molecular dynamics simulations, a novel catalytic reaction mechanism for plant PPOs is proposed. The presented results strongly suggest that the physiological role of plant catechol oxidases were previously underestimated, as they might hydroxylate their—so far unknown—natural substrates in vivo. PMID:26976571

  16. Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement

    PubMed Central

    Miller, Ami; Phillips, Anna; Gor, Jayesh; Wallis, Russell; Perkins, Stephen J.

    2012-01-01

    The complement system is a fundamental component of innate immunity that orchestrates complex immunological and inflammatory processes. Complement comprises over 30 proteins that eliminate invading microorganisms while maintaining host cell integrity. Protein-carbohydrate interactions play critical roles in both the activation and regulation of complement. Mannose-binding lectin (MBL) activates the lectin pathway of complement via the recognition of sugar arrays on pathogenic surfaces. To determine the solution structure of MBL, synchrotron x-ray scattering and analytical ultracentrifugation experiments showed that the carbohydrate-recognition domains in the MBL dimer, trimer, and tetramer are positioned close to each other in near-planar fan-like structures. These data were subjected to constrained modeling fits. A bent structure for the MBL monomer was identified starting from two crystal structures for its carbohydrate-recognition domain and its triple helical region. The MBL monomer structure was used to identify 10–12 near-planar solution structures for each of the MBL dimers, trimers, and tetramers starting from 900 to 6,859 randomized structures for each. These near-planar fan-like solution structures joined at an N-terminal hub clarified how the carbohydrate-recognition domain of MBL binds to pathogenic surfaces. They also provided insight on how MBL presents a structural template for the binding and auto-activation of the MBL-associated serine proteases to initiate the lectin pathway of complement activation. PMID:22167201

  17. Chlamydia screening for sexually active young women under the Affordable Care Act: new opportunities and lingering barriers.

    PubMed

    Loosier, Penny S; Malcarney, Mary-Beth; Slive, Lauren; Cramer, Ryan C; Burgess, Brittany; Hoover, Karen W; Romaguera, Raul

    2014-09-01

    The Affordable Care Act of 2010 (ACA) contains a provision requiring private insurers issuing or renewing plans on or after September 23, 2010, to provide, without cost sharing, preventive services recommended by US Preventive Services Task Force (grades A and B), among other recommending bodies. As a grade A recommendation, chlamydia screening for sexually active young women 24 years and younger and older women at risk for chlamydia falls under this requirement. This article examines the potential effect on chlamydia screening among this population across private and public health plans and identifies lingering barriers not addressed by this legislation. Examination of the impact on women with private insurance touches upon the distinction between coverage under grandfathered plans, where the requirement does not apply, and nongrandfathered plans, where the requirement does apply. Acquisition of private health insurance through health insurance Marketplaces is also discussed. For public health plans, coverage of preventive services without cost sharing differs for individuals enrolled in standard Medicaid, covered under the Medicaid expansion included in the ACA, or those enrolled under the Children's Health Insurance Program or who fall under Early, Periodic, Screening, Diagnosis and Treatment criteria. The discussion of lingering barriers not addressed by the ACA includes the uninsured, physician reimbursement, cost sharing, confidentiality, low rates of appropriate sexual history taking by providers, and disclosures of sensitive information. In addition, the role of safety net programs that provide health care to individuals regardless of ability to pay is examined in light of the expectation that they also remain a payer of last resort.

  18. Essays on Character & Opportunity

    ERIC Educational Resources Information Center

    Center on Children and Families at Brookings, 2014

    2014-01-01

    These essays provide richer set of writings on the philosophical, empirical and practical issues raised by a focus on character, and in particular its relationship to questions of opportunity. Each one is an intellectual pemmican: sharp and to the point. Two scholars draw attention to the gendered nature of character formation (Segal and Lexmond);…

  19. Creating Learning Opportunities for Students with Severe Disabilities in Inclusive Classrooms.

    ERIC Educational Resources Information Center

    Downing, June E.; Eichinger, Joanne

    2003-01-01

    This article discusses how professionals can recognize learning opportunities for students with severe disabilities within general education activities. It also includes examples of additional learning opportunities that provide ways for students to work on their individualized objectives in various settings. Recommendations are provided for…

  20. Let's Wiggle with 5-2-1-0: Curriculum Development for Training Childcare Providers to Promote Activity in Childcare Settings

    PubMed Central

    Venezia, Alexandra P.

    2016-01-01

    Overweight and obesity are increasing in preschool children in the US. Policy, systems, and environmental change interventions in childcare settings can improve obesity-related behaviors. The aim of this study was to develop and pilot an intervention to train childcare providers to promote physical activity (PA) in childcare classrooms. An evidence scan, key informant (n = 34) and focus group (n = 20) interviews with childcare directors and staff, and environmental self-assessment of childcare facilities (n = 22) informed the design of the training curriculum. Feedback from the interviews indicated that childcare providers believed in the importance of teaching children about PA and were supportive of training teachers to incorporate PA into classroom settings. The Promoting Physical Activity in Childcare Setting Curriculum was developed and training was implemented with 16 teachers. Participants reported a positive experience with the hands-on training and reported acquiring new knowledge that they intended to implement in their childcare settings. Our findings highlight the feasibility of working with childcare staff to develop PA training and curriculum. Next steps include evaluating the curriculum in additional childcare settings and childcare staff implementation of the curriculum to understand the effectiveness of the training on PA levels of children. PMID:27462468

  1. Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington’s Disease

    PubMed Central

    Sarantos, Melissa R.; Papanikolaou, Theodora; Ellerby, Lisa M.; Hughes, Robert E.

    2013-01-01

    Background Huntington’s disease (HD) is a dominantly inherited neurodegenerative condition characterized by dysfunction in striatal and cortical neurons. There are currently no approved drugs known to slow the progression of HD. Objective To facilitate the development of therapies for HD, we identified approved drugs that can ameliorate mutant huntingtin-induced toxicity in experimental models of HD. Methods A chemical screen was performed in a mouse HdhQ111/Q111 striatal cell model of HD. This screen identified a set of structurally related approved drugs (pizotifen, cyproheptadine, and loxapine) that rescued cell death in this model. Pizotifen was subsequently evaluated in the R6/2 HD mouse model. Results We found that in striatal HdhQ111/Q111 cells, pizotifen treatment caused transient ERK activation and inhibition of ERK activation prevented rescue of cell death in this model. In the R6/2 HD mouse model, treatment with pizotifen activated ERK in the striatum, reduced neurodegeneration and significantly enhanced motor performance. Conclusions These results suggest that pizotifen and related approved drugs may provide a basis for developing disease modifying therapeutic interventions for HD. PMID:23393546

  2. Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

    PubMed Central

    Cazes, Alex; Lopez-Delisle, Lucille; Tsarovina, Konstantina; Pierre-Eugène, Cécile; De Preter, Katleen; Peuchmaur, Michel; Nicolas, André; Provost, Claire; Louis-Brennetot, Caroline; Daveau, Romain; Kumps, Candy; Cascone, Ilaria; Schleiermacher, Gudrun; Prignon, Aurélie; Speleman, Frank; Rohrer, Hermann; Delattre, Olivier; Janoueix-Lerosey, Isabelle

    2014-01-01

    Activating mutations of the ALK (Anaplastic lymphoma Kinase) gene have been identified in sporadic and familial cases of neuroblastoma, a cancer of early childhood arising from the sympathetic nervous system (SNS). To decipher ALK function in neuroblastoma predisposition and oncogenesis, we have characterized knock-in (KI) mice bearing the two most frequent mutations observed in neuroblastoma patients. A dramatic enlargement of sympathetic ganglia is observed in AlkF1178L mice from embryonic to adult stages associated with an increased proliferation of sympathetic neuroblasts from E14.5 to birth. In a MYCN transgenic context, the F1178L mutation displays a higher oncogenic potential than the R1279Q mutation as evident from a shorter latency of tumor onset. We show that tumors expressing the R1279Q mutation are sensitive to ALK inhibition upon crizotinib treatment. Furthermore, our data provide evidence that activated ALK triggers RET upregulation in mouse sympathetic ganglia at birth as well as in murine and human neuroblastoma. Using vandetanib, we show that RET inhibition strongly impairs tumor growth in vivo in both MYCN/KI AlkR1279Q and MYCN/KI AlkF1178L mice. Altogether, our findings demonstrate the critical role of activated ALK in SNS development and pathogenesis and identify RET as a therapeutic target in ALK mutated neuroblastoma. PMID:24811913

  3. Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health.

    PubMed

    Lv, Xinmiao; Zhao, Siyu; Ning, Zhangchi; Zeng, Honglian; Shu, Yisong; Tao, Ou; Xiao, Cheng; Lu, Cheng; Liu, Yuanyan

    2015-01-01

    Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these fruits have been used as traditional medicinal herbs to cure diseases in several Asian countries. Numerous studies have focused on Citrus secondary metabolites as well as bioactivities and have been intended to develop new chemotherapeutic or complementary medicine in recent decades. Citrus-derived secondary metabolites, including flavonoids, alkaloids, limonoids, coumarins, carotenoids, phenolic acids and essential oils, are of vital importance to human health due to their active properties. These characteristics include anti-oxidative, anti-inflammatory, anti-cancer, as well as cardiovascular protective effects, neuroprotective effects, etc. This review summarizes the global distribution and taxonomy, numerous secondary metabolites and bioactivities of Citrus fruits to provide a reference for further study. Flavonoids as characteristic bioactive metabolites in Citrus fruits are mainly introduced.

  4. Co-Activation of Th17 and Antibody Responses Provides Efficient Protection against Mucosal Infection by Group A Streptococcus

    PubMed Central

    Chen, Xianyang; Li, Ning; Bi, Shuai; Wang, Xiaoguang; Wang, Beinan

    2016-01-01

    Conserved protein antigens among serotypes of group A Streptococcus pyogenes (GAS) have been focused for vaccine development because of the diversity of GAS serotypes and risks of autoimmunity post-GAS infection. Precise delineation of protective immune response to each of GAS antigens is critical for vaccine efficacy and safety. We recently reported that immunization with SrtA of GAS provides Th17-dependent clearance of heterologous serotypes of GAS in NALT. SCPA is a surface virulence molecule of GAS and known to induce antibody-mediated protection against GAS. We hypothesized that co-immunization with SrtA and SCPA would provide more efficient protection by eliciting combined Th17 and antibody responses. The present study showed that mice that were intranasally co-immunized with SrtA/SCPA cleared GAS more efficiently than the mice that were immunized with either SrtA or SCPA individually, and as efficient as the mice that experienced repeated GAS infections. The co-immunization induced Th17 and robust SCPA antibody responses, accompanied by a rapid influx of neutrophils and high myeloperoxidase activity in NALT, suggesting that simultaneous induction of mucosal Th17 and neutralizing antibody responses offers more effective GAS elimination through rapid infiltration and activation of neutrophils. Moreover, Th17 response was strongly induced in mice that experienced repeated GAS-infection and maintained at a high level even after the bacteria were cleared; whereas, it was moderately induced and promptly returned to baseline following bacterial elimination in SrtA/SCPA co-immunized mice. Additional results showed that the survival rate of systemic challenge was significantly higher in infection experienced than in co-immunized mice, indicating that more immune elements are required for protection against systemic than mucosal GAS infection. PMID:28030629

  5. Gamma-Irradiated Influenza A Virus Provides Adjuvant Activity to a Co-Administered Poorly Immunogenic SFV Vaccine in Mice

    PubMed Central

    Babb, Rachelle; Chan, Jennifer; Khairat, Jasmine E.; Furuya, Yoichi; Alsharifi, Mohammed

    2014-01-01

    Many currently available inactivated vaccines require “adjuvants” to maximize the protective immune responses generated against the antigens of interest. Recent studies in mice with gamma-irradiated influenza A virus (γ-FLU) have shown its superior efficacy compared to other forms of inactivated FLU vaccines and its ability to induce both potent interferon type-I (IFN-I) responses and the IFN-I-associated partial lymphocyte activation. Commonly, IFN-I responses induced by adjuvants, combined in vaccine preparations, have been shown to effectively enhance the immunogenicity of the antigens of interest. Therefore, we investigated the potential adjuvant activity of γ-FLU and the possible effect on antibody responses against co-administrated antigens, using gamma-irradiated Semliki Forest virus (γ-SFV) as the experimental vaccine in mice. Our data show that co-vaccination with γ-FLU and γ-SFV resulted in enhanced SFV-specific antibody responses in terms of increased titers by sixfold and greater neutralization efficacy, when compared to vaccination with γ-SFV alone. This study provides promising evidence related to the possible use of γ-FLU as an adjuvant to poorly immunogenic vaccines without compromising the vaccine efficacy of γ-FLU. PMID:24959166

  6. EQUALITY OF EDUCATIONAL OPPORTUNITY, RECONSIDERED.

    ERIC Educational Resources Information Center

    COLEMAN, JAMES S.

    THIS STUDY POSES THE QUESTION OF HOW TO MEASURE THE DEGREE OF INEQUALITY OF EDUCATIONAL OPPORTUNITY FOR SUBGROUPS IN SOCIETY. IT EXAMINES AND REJECTS THE DOMINANT IDEA THAT EQUAL EDUCATIONAL OPPORTUNITY IS PROVIDED BY A COMMUNITY THROUGH THE PROVISION OF FACILITIES WITH FREE AND OPEN ACCESS FOR ALL, SUBSTITUTING THE IDEA THAT IT IS THE INTENSITY…

  7. NUL Research History: Opportunity Magazine

    ERIC Educational Resources Information Center

    Urban League Review, 1976

    1976-01-01

    Discusses an official publication of the National Urban League, "Opportunity: Journal of Negro Life," first published in 1923. The purpose of "Opportunity" was to objectively present facts of Negro life through an analysis of social questions, to provide a basis of understanding and to encourage interracial cooperation in the…

  8. Ecological opportunity and the adaptive diversification of lineages

    PubMed Central

    Wellborn, Gary A; Langerhans, R Brian

    2015-01-01

    The tenet that ecological opportunity drives adaptive diversification has been central to theories of speciation since Darwin, yet no widely accepted definition or mechanistic framework for the concept currently exists. We propose a definition for ecological opportunity that provides an explicit mechanism for its action. In our formulation, ecological opportunity refers to environmental conditions that both permit the persistence of a lineage within a community, as well as generate divergent natural selection within that lineage. Thus, ecological opportunity arises from two fundamental elements: (1) niche availability, the ability of a population with a phenotype previously absent from a community to persist within that community and (2) niche discordance, the diversifying selection generated by the adaptive mismatch between a population's niche-related traits and the newly encountered ecological conditions. Evolutionary response to ecological opportunity is primarily governed by (1) spatiotemporal structure of ecological opportunity, which influences dynamics of selection and development of reproductive isolation and (2) diversification potential, the biological properties of a lineage that determine its capacity to diversify. Diversification under ecological opportunity proceeds as an increase in niche breadth, development of intraspecific ecotypes, speciation, and additional cycles of diversification that may themselves be triggered by speciation. Extensive ecological opportunity may exist in depauperate communities, but it is unclear whether ecological opportunity abates in species-rich communities. Because ecological opportunity should generally increase during times of rapid and multifarious environmental change, human activities may currently be generating elevated ecological opportunity – but so far little work has directly addressed this topic. Our framework highlights the need for greater synthesis of community ecology and evolutionary biology, unifying

  9. Testing Provides Crucial Information

    ERIC Educational Resources Information Center

    Morial, Marc H.

    2015-01-01

    The National Urban League president and CEO Marc H. Morial weighs in on what he sees as the need for continued annual assessments of students, rejecting the course of opting out that has taken hold in some places across America. Assessment data provides students with the opportunity to receive personalized supports and necessary interventions to…

  10. Progress, opportunities, and key fields for groundwater quality research under the impacts of human activities in China with a special focus on western China.

    PubMed

    Li, Peiyue; Tian, Rui; Xue, Chenyang; Wu, Jianhua

    2017-03-10

    Groundwater quality research is extremely important for supporting the safety of the water supply and human health in arid and semi-arid areas of China. This review article was constructed to report the latest research progress of groundwater quality in western China where groundwater quality is undergoing fast deterioration because of fast economic development and extensive anthropogenic activities. The opportunities brought by increasing public awareness of groundwater quality protection were also highlighted and discussed. To guide and promote further development of groundwater quality research in China, especially in western China, ten key groundwater quality research fields were proposed. The review shows that the intensification of human activities and the associated impacts on groundwater quality in China, especially in western China, has made groundwater quality research increasingly important, and has caught the attention of local, national, and international agencies and scholars. China has achieved some progress in groundwater quality research in terms of national and regional laws, regulations, and financial supports. The future of groundwater quality research in China, especially in western China, is promising reflected by the opportunities highlighted. The key research fields proposed in this article may also inform groundwater quality protection and management at the national and international level.

  11. Convergence Creates Opportunities Across Health Care System

    PubMed Central

    Fox, Brent I.; Felkey, Bill G.

    2014-01-01

    Industrial design students at Auburn do a creativity exercise where they are asked to combine a common household appliance with an animal. Have you seen a snake light? In health technology, we have a similar opportunity. In the connection between jewelry and vital sign monitoring technology or household security and health status monitoring, we are witnessing active convergence that will benefit patients, providers, and health systems. PMID:24958948

  12. Overview of energy-conservation research opportunities

    SciTech Connect

    Hopp, W.J.; Hauser, S.G.; Hane, G.J.; Gurwell, W.E.; Bird, S.P.; Cliff, W.C.; Williford, R.E.; Williams, T.A.; Ashton, W.B.

    1981-12-01

    This document is a study of research opportunities that are important to developing advanced technologies for efficient energy use. The study's purpose is to describe a wide array of attractive technical areas from which specific research and development programs could be implemented. Research areas are presented for potential application in each of the major end-use sectors. The study develops and applies a systematic approach to identifying and screening applied energy conservation research opportunities. To broadly cover the energy end-use sectors, this study develops useful information relating to the areas where federally-funded applied research will most likely play an important role in promoting energy conservation. This study is not designed to produce a detailed agenda of specific recommended research activities. The general information presented allows uniform comparisons of disparate research areas and as such provides the basis for formulating a cost-effective, comprehensive federal-applied energy conservation research strategy. Chapter 2 discusses the various methodologies that have been used in the past to identify research opportunities and details the approach used here. In Chapters 3, 4, and 5 the methodology is applied to the buildings, transportation, and industrial end-use sectors and the opportunities for applied research in these sectors are discussed.Chapter 6 synthesizes the results of the previous three chapters to give a comprehensive picture of applied energy conservation research opportunities across all end-use sectors and presents the conclusions to the report.

  13. ORYX: opportunity gained or lost?

    PubMed

    Rudman, W; Hewitt, C

    1999-06-01

    For HIM practitioners willing to extend their knowledge and scope of responsibility, the Joint Commission's ORYX initiative will provide new and exciting opportunities. Your level of involvement will depend on your willingness to expand your knowledge base and accept a leadership role within your organization. For those willing to change the way they think about data analysis/outcomes, ORYX will provide some of the most important and unlimited career opportunities that will be, or have ever been, offered to HIM professionals.

  14. Mister Rogers' Plan & Play Book: Activities from Mister Rogers' Neighborhood for Parents & Child Care Providers. Fourth Edition.

    ERIC Educational Resources Information Center

    Family Communications, Inc., Pittsburgh, PA.

    Intended for both childcare professionals and parents, this book lists activities from episodes of Mister Rogers' Neighborhood television program, and can be used with or without watching the program. Each activity is assigned a number which corresponds to the television episode in which the activity is featured, and a national PBS Broadcast…

  15. Land of the Rising Pulse: A Social Ecological Perspective of Physical Activity Opportunities for Schoolchildren in Japan

    ERIC Educational Resources Information Center

    Webster, Collin Andrew; Suzuki, Naoki

    2014-01-01

    The uptake of policies and recommendations to promote physical activity (PA) in American schools has been slow. It can be useful to investigate international contexts where school-based PA promotion has had more success and consider whether facilitative factors have transferability to American schools. This study employed a social ecological…

  16. Contractor report to the Department of Energy on opportunities for integration of environmental management activities across the complex (predecisional draft). Revision 1

    SciTech Connect

    1997-03-01

    The US Department of Energy (DOE) Environmental Management (EM) program faces significant technical and financial challenges in cleaning up the environmental legacy of nuclear weapons production and research and development, while facing an uncertain future in obtaining the needed funding to perform this work. Many of these requirements, including State and Federal regulations and negotiated agreements, continue to be a significant contributor to EM program costs and schedules. Historically, the sites have managed their programs focusing on their individual site`s needs. While this approach maximized successes at individual sites, it has resulted in a more costly program than if more integration across the DOE system occurred. In July 1996, the DOE Assistant Secretary for EM, Al Alm, chartered a contractor led effort to perform complex-wide integration in support of the ten-year plan process to develop a suite of technically defensible, integrated alternatives to meet the EM mission. This report documents opportunities for waste and nuclear materials management integration activities in six areas: transuranic (TRU) waste, mixed low-level waste (MLLW), low-level waste (LLW), environmental restoration (ER), high-level waste (HLW), and spent nuclear fuel (SNF). The opportunities represent technically defensible solutions which reduce cost, accelerate schedules, and result in no significant increase in risk.

  17. Symposium on Career Opportunities in Biomedical and Public Health Sciences

    NASA Technical Reports Server (NTRS)

    Sullivan, Walter W.

    1997-01-01

    The goal of the Symposium on Career Opportunities in Biomedical and Public Health Sciences is to encourage minority collegiate and junior and senior high school students to pursue careers in biomedical and public health sciences. The objectives of the Symposium are to: (1) Provide information to participants concerning biomedical and public health science careers in government, academe and industry; (2) Provide information to minority students about training activities necessary to pursue a biomedical or public health science career and the fiscal support that one can obtain for such training; and (3) Provide opportunities for participating minority biomedical and public health role models to interact with participants.

  18. The Feasibility of Using Nature-Based Settings for Physical Activity Programming: Views from Urban Youth and Program Providers

    ERIC Educational Resources Information Center

    Blanton, Jedediah E.; Oregon, Evelyn M.; Flett, M. Ryan; Gould, Daniel R.; Pfeiffer, Karin A.

    2013-01-01

    Background and Purpose: Given the urgency to design programs to increase physical activity, especially to combat obesity in children, the primary purpose of this study was to investigate perceptions and opinions of a nature-based physical activity intervention designed for low-income urban adolescents. Methods: Four focus groups of adolescents,…

  19. The opportunity for and significance of alteration of ribulose 1,5-bisphosphate carboxylase activities in crop production.

    PubMed

    Hardy, R W; Havelka, U D; Quebedeaux, B

    1978-01-01

    Increased population and the dietary changes accompanying increased affluence are creating a need for a suggested doubling of world cereal grain production (a 3% per year compounding rate) and quadrupling of grain legume production (a 6% per year compounding rate) during this quarter century (1). CO2 enrichment of field-grown crops has demonstrated the possibility of enhancing RuBP carboxylase activity to achieve improved crop production; it increases the production of grain legumes by 50 to 100% and that of cereal grains, for which the studies are less complete, by perhaps 10 to 50%. Results of O2 alteration of growth-room legumes and cereal grains are consistent with the results of CO2 enrichment except for a second role of O2 in assimilate partitioning. It may be necessary to include other components of the system, e.g., additional soil fertility, especially for non-N2-fixing plants, to enable an improved RuBP carboxylase to increase production. No practical method--chemical, genetic, or physical--of improving RuBP carboxylase activity has been reported.

  20. 77 FR 5039 - Accommodation Service Provided on Vessels Engaged in U.S. Outer Continental Shelf Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... SECURITY Coast Guard Accommodation Service Provided on Vessels Engaged in U.S. Outer Continental Shelf... providing accommodation service on the U.S. Outer Continental Shelf. DATES: Comments and related material... or reach the Docket Management Facility by that date. ADDRESSES: You may submit comments...

  1. The Opportunities of Crises and Emergency Risk Communication in Activities of Serbian Public Health Workforce in Emergencies

    PubMed Central

    Radović, V; Ćurčić, L

    2012-01-01

    Background: The aim of the study was a recommendation and establishment the concept of the appropriate communication between public health, other competent services and population in emergency as the corner stone which guarantee that all goals which are important for community life will be achieved. Methods: We used methodology appropriate for social science: analyses of documents, historical approach and comparative analysis. Results: The finding shows the urgent need for accepting of crises and emergency risk communication principles, or some similar concepts, in Serbia, and implementing effective two way communication especially in multiethnic region. The pragmatic value of the paper lays in information about the recent improvement of health workforce and emergency services in emergencies using new concept of communication and as source of numerous useful documents published in USA and few recent Serbian examples. Conclusion: Health workforce has significant role in the process of protection of population in emergencies. Policy makers should work on finding a way to improve their coordination and communication, creating new academic programs, providing of adequate training, and financial means in order to give them different role in society and provide visibility. From other side health workforce should build back to the citizen trust in what they are doing for society welfare using all their skills and abilities. PMID:23308348

  2. Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.

    PubMed

    Makarev, Evgeny; Cantor, Charles; Zhavoronkov, Alex; Buzdin, Anton; Aliper, Alexander; Csoka, Anotonei Benjamin

    2014-12-01

    Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, "AMD Medicine", and discovered differential pathway activation profiles in samples of human RPE/choroid from AMD patients and controls. We identified 29 pathways in RPE-choroid AMD phenotypes: 27 pathways were activated in AMD compared to controls, and 2 pathways were activated in controls compared to AMD. In AMD, we identified a graded activation of pathways related to wound response, complement cascade, and cell survival. Also, there was downregulation of two pathways responsible for apoptosis. Furthermore, significant activation of pro-mitotic pathways is consistent with dedifferentiation and cell proliferation events, which occur early in the pathogenesis of AMD. Significantly, we discovered new global pathway activation signatures of AMD involved in the cell-based inflammatory response: IL-2, STAT3, and ERK. The ultimate aim of our research is to achieve a better understanding of signaling pathways involved in AMD pathology, which will eventually lead to better treatments.

  3. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

    PubMed Central

    Martínez-Barricarte, Rubén; Heurich, Meike; Valdes-Cañedo, Francisco; Vazquez-Martul, Eduardo; Torreira, Eva; Montes, Tamara; Tortajada, Agustín; Pinto, Sheila; Lopez-Trascasa, Margarita; Morgan, B. Paul; Llorca, Oscar; Harris, Claire L.; Rodríguez de Córdoba, Santiago

    2010-01-01

    Dense deposit disease (DDD) is a severe renal disease characterized by accumulation of electron-dense material in the mesangium and glomerular basement membrane. Previously, DDD has been associated with deficiency of factor H (fH), a plasma regulator of the alternative pathway (AP) of complement activation, and studies in animal models have linked pathogenesis to the massive complement factor 3 (C3) activation caused by this deficiency. Here, we identified a unique DDD pedigree that associates disease with a mutation in the C3 gene. Mutant C3923ΔDG, which lacks 2 amino acids, could not be cleaved to C3b by the AP C3-convertase and was therefore the predominant circulating C3 protein in the patients. However, upon activation to C3b by proteases, or to C3(H2O) by spontaneous thioester hydrolysis, C3923ΔDG generated an active AP C3-convertase that was regulated normally by decay accelerating factor (DAF) but was resistant to decay by fH. Moreover, activated C3b923ΔDG and C3(H2O)923ΔDG were resistant to proteolysis by factor I (fI) in the presence of fH, but were efficiently inactivated in the presence of membrane cofactor protein (MCP). These characteristics cause a fluid phase–restricted AP dysregulation in the patients that continuously activated and consumed C3 produced by the normal C3 allele. These findings expose structural requirements in C3 that are critical for recognition of the substrate C3 by the AP C3-convertase and for the regulatory activities of fH, DAF, and MCP, all of which have implications for therapeutic developments. PMID:20852386

  4. 20 CFR 652.209 - What are the requirements under the Act for providing reemployment services and other activities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FUNCTIONING OF STATE EMPLOYMENT SERVICES Wagner-Peyser Act Services in a One-Stop Delivery System Environment... part of the One-Stop delivery system, must provide reemployment services to UI claimants for whom...

  5. The promiscuous and synergic molecular interaction of polyphenols in bactericidal activity: an opportunity to improve the performance of antibiotics?

    PubMed

    Tomás-Menor, Laura; Barrajón-Catalán, Enrique; Segura-Carretero, Antonio; Martí, Nuria; Saura, Domingo; Menéndez, Javier A; Joven, Jorge; Micol, Vicente

    2015-03-01

    Plant polyphenols are a potential source of new antimicrobial molecules against bacteria because most newly developed antimicrobial agents do not improve the clinical management of infectious diseases. The potential synergism between the major polyphenolic compounds present in a Cistus salviifolius extract, which was characterized by HPLC-ESI-MS/MS, was investigated by the isobole method and the fractional inhibitory concentration index determination. Pairwise combinations of selected flavonoids and ellagitannins present in C. salviifolius extract were assayed against the in vitro growth of Staphylococcus aureus. Some combinations revealed synergic effects, resulting in a reduction of the minimum inhibitory concentration required to inhibit 50% growth (MIC50 ) up to 20 times lower as compared with the individual compounds. Some of the combinations exhibited MIC50 values close to drug potency level (0.5-1 µg/mL). Punicalagin and myricetin were the major contributors in the combinations. The proportion between the compounds in the synergic mixtures is crucial and may explain the superior antimicrobial activity displayed by this extract when compared with other botanical extracts. The rational optimization of these combinations could lead to the design of potent antimicrobial phytopharmaceuticals, which may improve the performance of current antibiotics, taking advantage of the multi-targeted and synergic molecular interactions of selected polyphenols.

  6. Understanding contextual barriers, supports, and opportunities for physical activity among Mexican-origin children in Texas border colonias: A descriptive study

    PubMed Central

    2013-01-01

    Background The increasing numbers of colonias along the U.S.-Mexico border are characterized by disproportionately poor families of Mexican-origin, limited access to resources and health services, and heightened risk for obesity and diabetes. Despite consistent evidence supporting physical activity (PA) in prevention of chronic diseases, many individuals of Mexican-origin, including children, fail to meet PA recommendations. Environmental influences on PA, founded in ecological and social cognitive perspectives, have not been examined among children living in colonias. The purpose of this study was to identify and better understand (1) household and neighborhood environmental PA resources/supports, (2) perceived barriers to engaging in PA, and (3) PA offerings, locations, and transportation characteristics for Mexican-origin children living in colonias. Methods Data for this study were collected by promotora-researchers (indigenous community health workers trained in research methods) using face-to-face interviews conducted in Spanish. The sample consists of 94 mother-child dyads from Texas border colonias in Hidalgo County. Interviews included questionnaire items addressing PA barriers, household and neighborhood environmental support assessments conducted with each dyad, and open-ended questions that were coded to identify availability and locations of PA opportunities and transportation options. Descriptive statistics were calculated and differences between genders, birth countries, and BMI categories of children were determined using chi-square tests. Results All children were of Mexican-origin. The most frequently reported barriers were unleashed dogs in the street, heat, bad weather, traffic, no streetlights, and no place like a park to exercise. Prominent locations for current PA included schools, home, and parks. Common PA options for children were exercise equipment, running, playing, and sports. Environmental assessments identified exercise equipment

  7. The soil moisture active/passive (SMAP) mission: How we got here and what it will provide

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soil Moisture Active Passive (SMAP) satellite will be launched by the National Aeronautics and Space Administration in October 2014. This satellite is the culmination of basic research and applications development over the past thirty years. During most of this period, research and development o...

  8. Induction of lcc2 expression and activity by Agaricus bisporus provides defence against Trichoderma aggressivum toxic extracts.

    PubMed

    Sjaarda, Calvin P; Abubaker, Kamal S; Castle, Alan J

    2015-11-01

    Laccases are used by fungi for several functions including defence responses to stresses associated with attack by other fungi. Laccase activity changes and the induction of two laccase genes, lcc1 and lcc2, in Agaricus bisporus were measured in response to toxic extracts of medium in which Trichoderma aggressivum, the cause of green mould disease, was grown. A strain of A. bisporus that shows resistance to the extracts showed higher basal levels and greater enzymatic activity after extract exposure than did a sensitive strain. Furthermore, pre-incubation of T. aggressivum extract with laccases reduced toxicity. Faster induction and greater numbers of lcc2 transcripts in response to the extract were noted in the resistant strain than in the sensitive strain. The timing and increase in lcc2 transcript abundance mirrored changes in total laccase activity. No correlation between resistance and lcc1 transcription was apparent. Transcript abundance in transformants with a siRNA construct homologous to both genes varied widely. A strong negative correlation between transcript abundance and sensitivity of the transformant to toxic extract was observed in plate assays. These results indicated that laccase activity and in particular that encoded by lcc2 contributes to toxin metabolism and by extension green mould disease resistance.

  9. Induction of lcc2 expression and activity by Agaricus bisporus provides defence against Trichoderma aggressivum toxic extracts

    PubMed Central

    Sjaarda, Calvin P; Abubaker, Kamal S; Castle, Alan J

    2015-01-01

    Laccases are used by fungi for several functions including defence responses to stresses associated with attack by other fungi. Laccase activity changes and the induction of two laccase genes, lcc1 and lcc2, in Agaricus bisporus were measured in response to toxic extracts of medium in which Trichoderma aggressivum, the cause of green mould disease, was grown. A strain of A. bisporus that shows resistance to the extracts showed higher basal levels and greater enzymatic activity after extract exposure than did a sensitive strain. Furthermore, pre-incubation of T. aggressivum extract with laccases reduced toxicity. Faster induction and greater numbers of lcc2 transcripts in response to the extract were noted in the resistant strain than in the sensitive strain. The timing and increase in lcc2 transcript abundance mirrored changes in total laccase activity. No correlation between resistance and lcc1 transcription was apparent. Transcript abundance in transformants with a siRNA construct homologous to both genes varied widely. A strong negative correlation between transcript abundance and sensitivity of the transformant to toxic extract was observed in plate assays. These results indicated that laccase activity and in particular that encoded by lcc2 contributes to toxin metabolism and by extension green mould disease resistance. PMID:25824278

  10. 20 CFR 669.680 - What activities and services may be provided under the MSFW youth program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADMINISTRATION, DEPARTMENT OF LABOR NATIONAL FARMWORKER JOBS PROGRAM UNDER TITLE I OF THE WORKFORCE INVESTMENT..., as described in §§ 669.400 and 669.410; (2) Life skills activities which may include self and interpersonal skills development; (3) Community service projects; (4) Small business development...

  11. Structural modification of H/sub 2/-receptor antagonists provide post-H/sub 2/-receptor gastric antisecretory activity

    SciTech Connect

    Nielsen, S.T.; Dove, P.A.; Strike, D.P.; Schiehser, G.A.

    1986-03-01

    In the course of investigations into the gastric antisecretory activity of potential H/sub 2/-receptor antagonists, examples were discovered in which structural modification of the molecule altered a) antisecretory activity in the pylorus-ligated rat and b) the response to various stimulants of (/sup 14/C)aminopyrine (AP) uptake in isolated rat gastric mucosal cell preparations. Wy-45,662 (N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)thieno(3,4-d) isothiazol-3-amine 1, 1-dioxide)), a very potent histamine H/sub 2/-antagonist and antisecretory agent in the rat (ED/sub 50/ (approx.) 0.3 mg/kg), had no effect in vitro at 1 ..mu..M on forskolin-induced (/sup 14/C)AP uptake while 10 nM Wy-45,662 completely suppressed histamine-stimulated (/sup 14/C)AP uptake. In contrast, the N-benzylated form of Wy-45,662, Wy-46,499 dose-dependently (10/sup -7/-10/sup -6/M) suppressed forskolin-stimulated (/sup 14/C)AP uptake while retaining modest antisecretory activity (ED/sub 50/approx.8 mg/kg) in vivo. Wy-46,499's modest antisecretory activity was thus attributable to inhibition via a post-histamine H/sub 2/-receptor mechanism.

  12. Physical Activity for Young Children: A Quantitative Study of Child Care Providers' Knowledge, Attitudes, and Health Promotion Practices

    ERIC Educational Resources Information Center

    Lanigan, Jane

    2014-01-01

    Many preschool children fail to achieve the National Association for Sport and Physical Education physical activity recommendations placing themselves at increased risk of overweight and its associated health consequences. The early learning and care system is well positioned to intervene. Yet few child obesity prevention efforts have focused on…

  13. Domain organization of DNase from Thioalkalivibrio sp. provides insights into retention of activity in high salt environments

    PubMed Central

    Alzbutas, Gediminas; Kaniusaite, Milda; Grybauskas, Algirdas; Lagunavicius, Arunas

    2015-01-01

    Our study indicates that DNA binding domains are common in many halophilic or halotolerant bacterial DNases and they are potential activators of enzymatic activity at high ionic strength. Usually, proteins adapt to high ionic strength by increasing the number of negatively charged residues on the surface. However, in DNases such adaptation would hinder the binding to negatively charged DNA, a step critical for catalysis. In our study we demonstrate how evolution has solved this dilemma by engaging the DNA binding domain. We propose a mechanism, which enables the enzyme activity at salt concentrations as high as 4 M of sodium chloride, based on collected experimental data and domain structure analysis of a secreted bacterial DNase from the extremely halotolerant bacterium Thioalkalivibrio sp. K90mix. The enzyme harbors two domains: an N-terminal domain, that exhibits DNase activity, and a C-terminal domain, comprising a duplicate DNA binding helix-hairpin-helix motif. Here we present experimental data demonstrating that the C-terminal domain is responsible for the enzyme's resistance to high ionic strength. PMID:26191053

  14. Can an active aging index (AAI) provide insight into reducing elder abuse? A case study in Rajshahi District, Bangladesh.

    PubMed

    Tareque, Md Ismail; Ahmed, Md Munsur; Tiedt, Andrew D; Hoque, Nazrul

    2014-01-01

    We use data from respondents aged 60 years and above, collected during April 2009 in the Rajshahi district of Bangladesh, to examine whether high activeness, as captured by an AAI or in sub-domains, can help reduce the risk of elder abuse. The findings suggest that more than half of rural elderly and 14 percent of urban elderly were at some point abused. High activeness in health and security dimensions lowers the risk of being abused while those who are low active in community participation have the lowest risk of being abused in both rural and urban areas. Being literate (elderly with primary/secondary education) is revealed to be a significant factor that lowers the risk of abuse in both rural and urban areas. These results imply a need for educational programs that bolster positive and proper community interaction, in turn promoting a secure later life for elders, and reducing burden for families and society. High activeness in health and security dimensions should also be promoted to keep the elderly healthy and protect from abusive behavior.

  15. Activities of Secreted Aryl Alcohol Quinone Oxidoreductases from Pycnoporus cinnabarinus Provide Insights into Fungal Degradation of Plant Biomass.

    PubMed

    Mathieu, Yann; Piumi, Francois; Valli, Richard; Aramburu, Juan Carro; Ferreira, Patricia; Faulds, Craig B; Record, Eric

    2016-04-01

    Auxiliary activities family 3 subfamily 2 (AA3_2) from the CAZy database comprises various functions related to ligninolytic enzymes, such as fungal aryl alcohol oxidases (AAO) and glucose oxidases, both of which are flavoenzymes. The recent study of the Pycnoporus cinnabarinus CIRM BRFM 137 genome combined with its secretome revealed that four AA3_2 enzymes are secreted during biomass degradation. One of these AA3_2 enzymes, scf184803.g17, has recently been produced heterologously in Aspergillus niger Based on the enzyme's activity and specificity, it was assigned to the glucose dehydrogenases (PcinnabarinusGDH [PcGDH]). Here, we analyze the distribution of the other three AA3_2 enzymes (scf185002.g8, scf184611.g7, and scf184746.g13) to assess their putative functions. These proteins showed the highest homology with aryl alcohol oxidase from Pleurotus eryngii Biochemical characterization demonstrated that they were also flavoenzymes harboring flavin adenine dinucleotide (FAD) as a cofactor and able to oxidize a wide variety of phenolic and nonphenolic aryl alcohols and one aliphatic polyunsaturated primary alcohol. Though presenting homology with fungal AAOs, these enzymes exhibited greater efficiency in reducing electron acceptors (quinones and one artificial acceptor) than molecular oxygen and so were defined as aryl-alcohol:quinone oxidoreductases (AAQOs) with two enzymes possessing residual oxidase activity (PcAAQO2 and PcAAQO3). Structural comparison of PcAAQO homology models with P. eryngii AAO demonstrated a wider substrate access channel connecting the active-site cavity to the solvent, explaining the absence of activity with molecular oxygen. Finally, the ability of PcAAQOs to reduce radical intermediates generated by laccase from P. cinnabarinus was demonstrated, shedding light on the ligninolytic system of this fungus.

  16. Activities of Secreted Aryl Alcohol Quinone Oxidoreductases from Pycnoporus cinnabarinus Provide Insights into Fungal Degradation of Plant Biomass

    PubMed Central

    Piumi, Francois; Valli, Richard; Aramburu, Juan Carro; Ferreira, Patricia; Faulds, Craig B.; Record, Eric

    2016-01-01

    Auxiliary activities family 3 subfamily 2 (AA3_2) from the CAZy database comprises various functions related to ligninolytic enzymes, such as fungal aryl alcohol oxidases (AAO) and glucose oxidases, both of which are flavoenzymes. The recent study of the Pycnoporus cinnabarinus CIRM BRFM 137 genome combined with its secretome revealed that four AA3_2 enzymes are secreted during biomass degradation. One of these AA3_2 enzymes, scf184803.g17, has recently been produced heterologously in Aspergillus niger. Based on the enzyme's activity and specificity, it was assigned to the glucose dehydrogenases (P. cinnabarinus GDH [PcGDH]). Here, we analyze the distribution of the other three AA3_2 enzymes (scf185002.g8, scf184611.g7, and scf184746.g13) to assess their putative functions. These proteins showed the highest homology with aryl alcohol oxidase from Pleurotus eryngii. Biochemical characterization demonstrated that they were also flavoenzymes harboring flavin adenine dinucleotide (FAD) as a cofactor and able to oxidize a wide variety of phenolic and nonphenolic aryl alcohols and one aliphatic polyunsaturated primary alcohol. Though presenting homology with fungal AAOs, these enzymes exhibited greater efficiency in reducing electron acceptors (quinones and one artificial acceptor) than molecular oxygen and so were defined as aryl-alcohol:quinone oxidoreductases (AAQOs) with two enzymes possessing residual oxidase activity (PcAAQO2 and PcAAQO3). Structural comparison of PcAAQO homology models with P. eryngii AAO demonstrated a wider substrate access channel connecting the active-site cavity to the solvent, explaining the absence of activity with molecular oxygen. Finally, the ability of PcAAQOs to reduce radical intermediates generated by laccase from P. cinnabarinus was demonstrated, shedding light on the ligninolytic system of this fungus. PMID:26873317

  17. Hydrologic opportunities in the GPM mission

    NASA Astrophysics Data System (ADS)

    Lettenmaier, D. P.

    2012-12-01

    Launch of the Global Precipitation Measurement mission mother satellite in early 2014 will offer unprecedented opportunities to the hydrologic community, yet these opportunities are not widely known beyond the relatively small cross-section of the community that has been involved in NASA (and other space agency) funded research. Hydrologists are most familiar with precipitation measurements from traditional gauge-based methods - and to a lesser extent, surface radars. I discuss new opportunities for the community in terms of the potential for a truly global view of land surface hydrologic processes, as well as applications to flood and drought prediction that GPM will provide. I also review briefly the legacy of TRMM precipitation products, including the evolution of the TMPA series of products, particularly those that do not require gauge correction, and ongoing applications, and comment on opportunities for the community in the next generation of satellite based water cycle measurements. These include GPM, as well as NASA's Soil Moisture Active Passive (SMAP) mission, also projected for launch in 2014, and the joint U.S.-French Surface Water and Ocean Topography (SWOT) mission, planned for launch late in the decade.

  18. Opportunities for international collaboration in industrial pollution prevention

    SciTech Connect

    Young, J.K.; Fowler, K.M.

    1993-08-01

    The goal of this paper is to describe international research opportunities for in-process reduction of wastes from industrial processes. Written responses from 52 researchers were obtained from 15 different countries in mid-1992. Each researcher provided information about products to reduce waste in industrial processes and recommended joint activities and mechanisms for working collaboratively with the United States.

  19. Nanotechnology: Opportunities and Challenges

    NASA Technical Reports Server (NTRS)

    Meyyappan, Meyya

    2003-01-01

    Nanotechnology seeks to exploit novel physical, chemical, biological, mechanical, electrical, and other properties, which arise primarily due to the nanoscale nature of certain materials. A key example is carbon nanotubes (CNTs) which exhibit unique electrical and extraordinary mechanical properties and offer remarkable potential for revolutionary applications in electronics devices, computing, and data storage technology, sensors, composites, nanoelectromechanical systems (NEMS), and as tip in scanning probe microscopy (SPM) for imaging and nanolithography. Thus the CNT synthesis, characterization, and applications touch upon all disciplines of science and engineering. This presentation will provide an overview and progress report on this and other major research candidates in Nanotechnology and address opportunities and challenges ahead.

  20. The Role of Security Concerns in Determining Information Systems/Technology Activities Outsourced to Offshore Service Providers in India

    ERIC Educational Resources Information Center

    Ocholi, Smart

    2012-01-01

    Based on research studies, the Information System/Technology (IS/T) outsourcing industry in India is reasoned to maintain the status quo of providing IS/T services at the lower level of the IS/T value chain. The 2006 study conducted by Walsh supported the 2001 findings by Arora, Arunachalam, Asundi, and Fernandes that India-based IS /T service…

  1. Structures of almond hydroxynitrile lyase isoenzyme 5 provide a rationale for the lack of oxidoreductase activity in flavin dependent HNLs.

    PubMed

    Pavkov-Keller, Tea; Bakhuis, Janny; Steinkellner, Georg; Jolink, Fenneke; Keijmel, Esther; Birner-Gruenberger, Ruth; Gruber, Karl

    2016-10-10

    Hydroxynitrile lyases (HNLs) catalyze the asymmetric addition of HCN to aldehydes producing enantiomerically pure cyanohydrins. These enzymes can be heterologously expressed in large quantities making them interesting candidates for industrial applications. The HNLs from Rosaceae evolved from flavin dependent dehydrogenase/oxidase structures. Here we report the high resolution X-ray structure of the highly glycosylated Prunus amygdalus HNL isoenzyme5 (PaHNL5 V317A) expressed in Aspergillus niger and its complex with benzyl alcohol. A comparison with the structure of isoenzyme PaHNL1 indicates a higher accessibility to the active site and a larger cavity for PaHNL5. Additionally, the PaHNL5 complex structure with benzyl alcohol was compared with the structurally related aryl-alcohol oxidase (AAO). Even though both enzymes contain an FAD-cofactor and histidine residues at crucial positions in the active site, PaHNL5 lacks the oxidoreductase activity. The structures indicate that in PaHNLs benzyl alcohol is bound too far away from the FAD cofactor in order to be oxidized.

  2. A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson's Disease Models.

    PubMed

    Lee, Ji Ae; Son, Hyo Jin; Park, Ki Duk; Han, Se Hee; Shin, Nari; Kim, Ji Hyun; Kim, Hye Ri; Kim, Dong Jin; Hwang, Onyou

    2015-11-01

    Parkinson's disease (PD) is a progressive neurodegenerative disorder accompanied by a selective loss of the dopamine(DA)ergic neurons residing in the substantia nigra. There is ample evidence that neuroinflammation and oxidative stress are involved in the pathogenesis of PD. In the present study, we aimed at protecting the DAergic neurons by suppressing these cellular events and generated a novel synthetic isothiocyanate ITC-3. The compound led to elevation of nuclear and total levels of the transcription factor Nrf2 and interacted with its binding protein Keap1 with high affinity, suggesting Nrf2 activation. ITC-3 was able to suppress production of the proinflammatory mediators in lipopolysaccharide-activated BV-2 microglial cells. It also increased mRNA and protein levels of the Nrf2-dependent antioxidant enzymes NAD(P)H quinone oxidoreductase, heme oxygenase-1, and glutamylcysteine ligase in both BV-2 and DAergic neuronal CATH.a cells. The compound protected the DAergic cells against oxidative stress. In vivo, ITC-3 attenuated the loss of tyrosine hydroxylase-immunopositive nigrostriatal DAergic neurons, suppressed microglial activation, and abolished PD-associated motor deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-elicited animal model of PD. Taken together, ITC-3 may be useful toward development of neuroprotective therapy for PD.

  3. Substitutions of Thr30 provide mechanistic insight into tryptophan-mediated activation of TRAP binding to RNA.

    PubMed

    Payal, Vandana; Gollnick, Paul

    2006-01-01

    TRAP is an 11 subunit RNA binding protein that regulates expression of genes involved in tryptophan biosynthesis and transport in Bacillus subtilis. TRAP is activated to bind RNA by binding up to 11 molecules of l-tryptophan in pockets formed by adjacent subunits. The precise mechanism by which tryptophan binding activates TRAP is not known. Thr30 is in the tryptophan binding pocket. A TRAP mutant in which Thr30 is substituted with Val (T30V) does not bind tryptophan but binds RNA constitutively, suggesting that Thr30 plays a key role in the activation mechanism. We have examined the effects of other substitutions of Thr30. TRAP proteins with small beta-branched aliphatic side chains at residue 30 bind RNA constitutively, whereas those with a small polar side chain show tryptophan-dependent RNA binding. Several mutant proteins exhibited constitutive RNA binding that was enhanced by tryptophan. Although the tryptophan and RNA binding sites on TRAP are distinct and are separated by approximately 7.5 A, several substitutions of residues that interact with the bound RNA restored tryptophan binding to T30V TRAP. These observations support the hypothesis that conformational changes in TRAP relay information between the tryptophan and RNA binding sites of the protein.

  4. Health systems in the Republic of Congo: challenges and opportunities for implementing tuberculosis and HIV collaborative service, research, and training activities.

    PubMed

    Linguissi, Laure Stella Ghoma; Gwom, Luc Christian; Nkenfou, Celine Nguefeu; Bates, Matthew; Petersen, Eskild; Zumla, Alimuddin; Ntoumi, Francine

    2017-03-01

    The Republic of Congo is on the World Health Organization (WHO) list of 'high burden' countries for tuberculosis (TB) and HIV. TB is the leading cause of death among HIV-infected patients in the Republic of Congo. In this viewpoint, the available data on TB and HIV in the Republic of Congo are reviewed, and the gaps and bottlenecks that the National TB Control Program (NTCP) faces are discussed. Furthermore, priority requirements for developing and implementing TB and HIV collaborative service activities are identified. HIV and TB control programs operate as distinct entities with separate case management plans. The implementation of collaborative TB/HIV activities to evaluate and monitor the management of TB/HIV co-infected individuals remains inefficient in most regions, and these activities are sometimes non-existent. This reveals major challenges that require definition in order to improve the delivery of healthcare. The NTCP lacks adequate resources for optimal implementation of control measures of TB and HIV compliance and outcomes. The importance of aligning and integrating TB and HIV treatment services (including follow-up) and adherence support services through coordinated and collaborative efforts between individual TB and HIV programs is discussed. Aligning and integrating TB and HIV treatment services through coordinated and collaborative efforts between individual TB and HIV programs is required. However, the WHO recommendations are generic, and health services in the Republic of Congo need to tailor their TB and HIV programs according to the availability of resources and operational feasibility. This will also open opportunities for synergizing collaborative TB/HIV research and training activities, which should be prioritized by the donors supporting the TB/HIV programs.

  5. Can Thromboelastography performed on kaolin-activated citrated samples from critically ill patients provide stable and consistent parameters?

    PubMed

    White, H; Zollinger, C; Jones, M; Bird, R

    2010-04-01

    Thromboelastography (TEG) is a potentially useful tool but analysis within 4-6 min of collection imposes limitations on its use and access. The use of citrate blood tubes potentially increases the time frame for processing specimens. There is, however, limited research on the stability of citrate specimens, timing of processing and the accuracy of TEG results. The purpose of this study was to examine the effects of early and delayed processing on TEG parameters using kaolin-activated citrated blood samples in the intensive care population. TEG analysis was performed on 61 patients. Blood was collected into two 3.2% sodium citrate (0.105 m) tubes. Kaolin-activated samples were analysed at 15, 30 and 120 min postcollection. TEG parameters analysed included reaction time (R), clot formation time (K), alpha angle (alpha), maximum amplitude, LY30, the coagulation index, time to maximum rate of thrombus generation, maximum rate of thrombus generation and total thrombus generation. Sixty-one critically ill patients were included. The results of the anova showed that time from collection was significantly associated with the TEG((R)) results (P < 0.05). On comparison of individual outcome variables, this difference in most cases was due to changes over time from 30 to 120 min. Furthermore, progressive changes in TEG parameters such as decreasing R were suggestive of a trend toward hypercoagulability of the specimens. Processing of kaolin-activated citrate TEG specimens can begin as early as 15 min postvenipuncture. However, delaying processing by more than 30 min leads to a significant change in results.

  6. Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms.

    PubMed

    Ramsay, Andrew J; Quesada, Victor; Sanchez, Mayka; Garabaya, Cecilia; Sardà, María P; Baiget, Montserrat; Remacha, Angel; Velasco, Gloria; López-Otín, Carlos

    2009-10-01

    Mutations leading to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia (IRIDA) due to elevated hepcidin levels. Here we describe two novel heterozygous mutations within the matriptase-2 (TMPRSS6) gene of monozygotic twin girls exhibiting an IRIDA phenotype. The first is the frameshift mutation (P686fs) caused by the insertion of the four nucleotides CCCC in exon 16 (2172_2173insCCCC) that is predicted to terminate translation before the catalytic serine. The second mutation is the di-nucleotide substitution c.467C>A and c.468C>T in exon 3 that causes the missense mutation A118D in the SEA domain of the extracellular stem region of matriptase-2. Functional analysis of both variant matriptase-2 proteases has revealed that they lead to ineffective suppression of hepcidin transcription. We also demonstrate that the A118D SEA domain mutation causes an intra-molecular structural imbalance that impairs matriptase-2 activation. Collectively, these results extend the pattern of TMPRSS6 mutations associated with IRIDA and functionally demonstrate that mutations affecting protease regions other than the catalytic domain may have a profound impact in the regulatory role of matriptase-2 during iron deficiency.

  7. A forced damped oscillation framework for undulatory swimming provides new insights into how propulsion arises in active and passive swimming.

    PubMed

    Bhalla, Amneet Pal Singh; Griffith, Boyce E; Patankar, Neelesh A

    2013-01-01

    A fundamental issue in locomotion is to understand how muscle forcing produces apparently complex deformation kinematics leading to movement of animals like undulatory swimmers. The question of whether complicated muscle forcing is required to create the observed deformation kinematics is central to the understanding of how animals control movement. In this work, a forced damped oscillation framework is applied to a chain-link model for undulatory swimming to understand how forcing leads to deformation and movement. A unified understanding of swimming, caused by muscle contractions ("active" swimming) or by forces imparted by the surrounding fluid ("passive" swimming), is obtained. We show that the forcing triggers the first few deformation modes of the body, which in turn cause the translational motion. We show that relatively simple forcing patterns can trigger seemingly complex deformation kinematics that lead to movement. For given muscle activation, the forcing frequency relative to the natural frequency of the damped oscillator is important for the emergent deformation characteristics of the body. The proposed approach also leads to a qualitative understanding of optimal deformation kinematics for fast swimming. These results, based on a chain-link model of swimming, are confirmed by fully resolved computational fluid dynamics (CFD) simulations. Prior results from the literature on the optimal value of stiffness for maximum speed are explained.

  8. Switching the centromeres on and off: epigenetic chromatin alterations provide plasticity in centromere activity stabilizing aberrant dicentric chromosomes.

    PubMed

    Sato, Hiroshi; Saitoh, Shigeaki

    2013-12-01

    The kinetochore, which forms on a specific chromosomal locus called the centromere, mediates interactions between the chromosome and the spindle during mitosis and meiosis. Abnormal chromosome rearrangements and/or neocentromere formation can cause the presence of multiple centromeres on a single chromosome, which results in chromosome breakage or cell cycle arrest. Analyses of artificial dicentric chromosomes suggested that the activity of the centromere is regulated epigenetically; on some stably maintained dicentric chromosomes, one of the centromeres no longer functions as a platform for kinetochore formation, although the DNA sequence remains intact. Such epigenetic centromere inactivation occurs in cells of various eukaryotes harbouring 'regional centromeres', such as those of maize, fission yeast and humans, suggesting that the position of the active centromere is determined by epigenetic markers on a chromosome rather than the nucleotide sequence. Our recent findings in fission yeast revealed that epigenetic centromere inactivation consists of two steps: disassembly of the kinetochore initiates inactivation and subsequent heterochromatinization prevents revival of the inactivated centromere. Kinetochore disassembly followed by heterochromatinization is also observed in normal senescent human cells. Thus epigenetic centromere inactivation may not only stabilize abnormally generated dicentric chromosomes, but also be part of an intrinsic mechanism regulating cell proliferation.

  9. Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress

    PubMed Central

    Lui, Jennifer; Castelli, Lydia M.; Pizzinga, Mariavittoria; Simpson, Clare E.; Hoyle, Nathaniel P.; Bailey, Kathryn L.; Campbell, Susan G.; Ashe, Mark P.

    2014-01-01

    Summary The localization of mRNA to defined cytoplasmic sites in eukaryotic cells not only allows localized protein production but also determines the fate of mRNAs. For instance, translationally repressed mRNAs localize to P-bodies and stress granules where their decay and storage, respectively, are directed. Here, we find that several mRNAs are localized to granules in unstressed, actively growing cells. These granules play a key role in the stress-dependent formation of P-bodies. Specific glycolytic mRNAs are colocalized in multiple granules per cell, which aggregate during P-body formation. Such aggregation is still observed under conditions or in mutants where P-bodies do not form. In unstressed cells, the mRNA granules appear associated with active translation; this might enable a coregulation of protein expression from the same pathways or complexes. Parallels can be drawn between this coregulation and the advantage of operons in prokaryotic systems. PMID:25437551

  10. Activation of the Albino Sterlet Acipenser ruthenus Eggs by UV-Irradiated Bester Hybrid Spermatozoa to Provide Gynogenetic Progeny.

    PubMed

    Fopp-Bayat, D; Ocalewicz, K

    2015-08-01

    Meiotic gynogenesis was induced in the albino form of sterlet Acipenser ruthenus by activation of eggs with UV-irradiated bester (Huso huso x Acipenser ruthenus) spermatozoa followed by inhibition of the second meiotic division performed by a heat shock. Obtained putative gynogenetic progeny were all albinos. The genetic verification based on three microsatellite DNA markers confirmed the only maternal inheritance of the progeny from the gynogenetic experimental groups. Cytogenetic analysis proved the gynogenetic sterlets were diploids. Application of the albino phenotype together with the molecular and the cytogenetic diagnostic approaches enabled to evaluate the efficiency of the spermatozoa irradiation and application of the heat shock to restore diploid state in the gynogenetic zygotes.

  11. Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

    PubMed Central

    Richardson, Andrew P.; Halestrap, Andrew P.

    2016-01-01

    Inhibition of the mitochondrial permeability transition pore (MPTP) by the novel inhibitor GNX-4975 was characterized. Titration of MPTP activity in de-energized rat liver mitochondria allowed determination of the number of GNX-4975-binding sites and their dissociation constant (Ki). Binding sites increased in number when MPTP opening was activated by increasing [Ca2+], phenylarsine oxide (PAO) or KSCN, and decreased when MPTP opening was inhibited with bongkrekic acid (BKA) or ADP. Values ranged between 9 and 50 pmol/mg of mitochondrial protein, but the Ki remained unchanged at ∼1.8 nM when the inhibitor was added before Ca2+. However, when GNX-4975 was added after Ca2+ it was much less potent with a Ki of ∼140 nM. These data imply that a protein conformational change is required to form the MPTP complex and generate the GNX-4975-binding site. Occupation of the latter with GNX-4975 prevents the Ca2+ binding that triggers pore opening. We also demonstrated that GNX-4975 stabilizes an interaction between the adenine nucleotide translocase (ANT), held in its ‘c’ conformation with carboxyatractyloside (CAT), and the phosphate carrier (PiC) bound to immobilized PAO. No components of the F1Fo-ATP synthase bound significantly to immobilized PAO. Our data are consistent with our previous proposal that the MPTP may form at an interface between the PiC and ANT (or other similar mitochondrial carrier proteins) when they adopt novel conformations induced by factors that sensitize the MPTP to [Ca2+]. We propose that GNX-4975 binds to this interface preventing a calcium-triggered event that opens the interface into a pore. PMID:26920024

  12. Athletics for All: Providing Opportunities for Students of All Abilities

    ERIC Educational Resources Information Center

    Whitmer, Regina

    2013-01-01

    The glory days of high school sports are no longer reserved for dream team athletes, as athletic directors are increasingly opening up sports to all students, regardless of ability, and seeing winning results on the field and off. This push is reflected in the most recent National Federation of State High School Associations (NFHS) survey, which…

  13. Gifted Children & the Arts: Providing Opportunities for All

    ERIC Educational Resources Information Center

    Schroth, Stephen T.; Helfer, Jason A.

    2011-01-01

    Knowledge of English/language arts, mathematics, and the sciences are considered important in the development of gifted children. Familiarity with the arts--music, the visual arts, dance, creative writing, and theatre--is, for many, a more difficult proposition. Budget cutbacks have marginalized the art offerings in numerous school districts…

  14. Do We Provide Opportunities or Only Value Productivity?

    ERIC Educational Resources Information Center

    de la Iglesia Mayol, Begona

    2006-01-01

    With a view to improving the quality of life of persons living with disabilities without direct intervention but in the context of action at the level of their personal development, and with the institutional support of the University of the Balearic Islands and funding from "SA Nostra" Caixa de Balears, we decided to develop, implement…

  15. Isothermal Titration Calorimetry Can Provide Critical Thinking Opportunities

    ERIC Educational Resources Information Center

    Moore, Dale E.; Goode, David R.; Seney, Caryn S.; Boatwright, Jennifer M.

    2016-01-01

    College chemistry faculties might not have considered including isothermal titration calorimetry (ITC) in their majors' curriculum because experimental data from this instrumental method are often analyzed via automation (software). However, the software-based data analysis can be replaced with a spreadsheet-based analysis that is readily…

  16. Soot and short-lived pollutants provide political opportunity

    NASA Astrophysics Data System (ADS)

    Victor, David G.; Zaelke, Durwood; Ramanathan, Veerabhadran

    2015-09-01

    Cutting levels of soot and other short-lived pollutants delivers tangible benefits and helps governments to build confidence that collective action on climate change is feasible. After the Paris climate meeting this December, actually reducing these pollutants will be essential to the credibility of the diplomatic process.

  17. Building a Strong Foundation: Apprenticeships Provide Earning, Learning Opportunities

    ERIC Educational Resources Information Center

    Finkel, Ed

    2016-01-01

    Partnerships between community colleges and employers to create apprenticeships have been around for decades. These traditionally have covered fields like the building trades--electrical, construction and others--as well as heavy manufacturing like the automobile industry. Inspired partly by a new federal apprenticeship consortium--and $175…

  18. Maximizing the Opportunity Provided by "Race to the Top"

    ERIC Educational Resources Information Center

    Hershberg, Theodore; Robertson-Kraft, Claire

    2010-01-01

    Education policy makers have long searched for a system that will recognize and reward outstanding practice, support educators to improve their performance, and, most importantly, increase student achievement. For states and school districts to secure grants from the $4.35 billion Race to the Top (RTTT) Fund, President Barack Obama is requiring…

  19. Uranium azide photolysis results in C-H bond activation and provides evidence for a terminal uranium nitride

    NASA Astrophysics Data System (ADS)

    Thomson, Robert K.; Cantat, Thibault; Scott, Brian L.; Morris, David E.; Batista, Enrique R.; Kiplinger, Jaqueline L.

    2010-09-01

    Uranium nitride [U≡N]x is an alternative nuclear fuel that has great potential in the expanding future of nuclear power; however, very little is known about the U≡N functionality. We show, for the first time, that a terminal uranium nitride complex can be generated by photolysis of an azide (U-N=N=N) precursor. The transient U≡N fragment is reactive and undergoes insertion into a ligand C-H bond to generate new N-H and N-C bonds. The mechanism of this unprecedented reaction has been evaluated through computational and spectroscopic studies, which reveal that the photochemical azide activation pathway can be shut down through coordination of the terminal azide ligand to the Lewis acid B(C6F5)3. These studies demonstrate that photochemistry can be a powerful tool for inducing redox transformations for organometallic actinide complexes, and that the terminal uranium nitride fragment is reactive, cleaving strong C-H bonds.

  20. Radical scavenging activity of a sunscreen enriched by antioxidants providing protection in the whole solar spectral range.

    PubMed

    Souza, Carla; Campos, Patrícia Maia; Schanzer, Sabine; Albrecht, Stephanie; Lohan, Silke B; Lademann, Juergen; Darvin, Maxim E; Meinke, Martina C

    2017-03-21

    The literature claims that incorporation of antioxidants into sunscreens provides additional skin photoprotection by scavenging free radicals formed due to sun radiation, but there are limited in vivo studies that support this hypothesis. This study aims to examine whether addition of antioxidants to a broad-spectrum sunscreen increases its photoprotective effect in real-use conditions. Sunscreen formulations composed of stable UV filters (Tinosorb® S, Tinosorb® M, Uvinul® APlus, and Uvinul® T150) alone or in combination with antioxidants (Spirulina and dimethylmethoxy chromanol-loaded solid lipid nanoparticles) were developed and their appearance, odor, rheological behavior, Sun Protection Factor (SPF), and UVA protection were analyzed. Next, it was conducted a 3-month, single-blind clinical study with 44 healthy subjects (30-50years). Before and 28, 54, and 84days after twice-daily self application of the sunscreens on the face, the stratum corneum water content, transepidermal water loss, dermis echogenicity, and skin elasticity and pigmentation were measured. At the end of the study period, the volunteers answered a questionnaire containing terms related to sensory characteristics of the formulations. All formulations were stable and exhibited non-Newtonian and pseudoplastic behavior, in vivo SPF 30, and good UVA protection. Antioxidant supplementation to the sunscreen formulation significantly improved the skin pigmentation, the collagen degradation on the dermis and thereby the skin net elasticity after 84days of treatment compared to the sunscreen alone. Concerning safety, all formulations were considered non-irritant according to the sensorial analyses, whose results agreed with the clinical study findings.

  1. Telemetry provides new insights into entrainment of activity wheel circadian rhythms and the role of body temperature in the development of ulcers in the activity-stress paradigm.

    PubMed

    Murphy, Helen M; Wideman, Cyrilla H; Aquila, Louise A; Nadzam, George R

    2002-01-01

    Two methods of monitoring the circadian rhythm of activity in rodents: (1) an activity wheel cage, which detects the number of wheel revolutions, and (2) an internal radio transmitter, which records gross motor activity (GMA) of the animal, were compared in both normal circadian cycles and during the development of activity-stress ulcers. Rats were implanted with a biotelemetry transmitter that detected GMA and body temperature (BT) and placed in activity wheel cages. A 12 hour/12 hour light/dark cycle was maintained throughout the experiment. Subjects were subdivided into two groups: (1) unlimited access to activity wheel (AW) cages and (2) locked activity wheel (LW) cages. Following an ad-libitum habituation period, animals were allowed food access for 1 hour/day during the light. In the habituation period, the animals showed higher GMA and BT during the dark phase when housed in AW cages than in LW cages. Both GMA and number of wheel revolutions increased dramatically after the onset of food restriction for the AW animals. There was a deleterious drop in BT in AW animals as the food-restricted period continued and a significant correlation existed between severity of ulcerations and BT. The findings of this experiment demonstrate that the activity wheel imposes an alternation of the circadian cycle, which, in turn, influences rhythmicity through reentrainment. Additionally, in the activity-stress paradigm, a significant drop in BT correlates with severity of ulcerations. A disrupted circadian cycle, involving hypothermia, is proposed as the mechanism underlying the demise of animals in the activity-stress paradigm.

  2. 20 CFR 645.225 - How do Welfare-to-Work activities relate to activities provided through TANF and other related...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... General Program and Administrative Requirements § 645.225 How do Welfare-to-Work activities relate to...(a)(5)(A)(vii)(II)). (b) The operating entity must ensure that there is an assessment of...

  3. Opportunity Cost: A Reexamination

    ERIC Educational Resources Information Center

    Parkin, Michael

    2016-01-01

    Is opportunity cost an ambiguous and arbitrary concept or a simple, straightforward, and fruitful one? This reexamination of opportunity cost addresses this question, and shows that opportunity cost is an ambiguous concept because "two" definitions are in widespread use. One of the definitions is indeed simple, fruitful, and one that…

  4. Links and opportunities

    NASA Astrophysics Data System (ADS)

    1999-09-01

    At the end of June a new website was launched to enable young people to get involved with the UK's national Foresight programme and to help shape the future. `School of the Future - Young people with Foresight' will provide young people with the means to contribute to the national programme which develops scenarios of the future, looking at possible needs, opportunities or threats and deciding what should be done now to make sure these challenges can be met. The site can be found at www.asset.org.uk and it will be run by the Association for Schools' Science, Engineering and Technology (ASSET). The latest round of Foresight began in April and panels are taking a look at the aging population, crime prevention, built environment and transport, aerospace and systems, energy and the natural environment, information, communications and media, materials and sustainable development, amongst other topics. Information about Foresight activities and events can be obtained from the Office of Science and Technology or the Foresight Knowledge pool at www.foresight.gov.uk. The pool will act as a unique and freely accessible electronic library of views and information about the future that young people will be able to draw on for assistance and reference material. Futher assistance for students will also be on offer from museums and art galleries from now on, thanks to additional funding which has been made available over the next three years. Forty museums and galleries will share up to #2.5m for projects intended to improve students' literacy, numeracy and science skills as well as their understanding of history and art. Examples of the imaginative projects which have been put forward include use of the large collection of steam engines at the Museum of Science and Industry in Manchester to assist boys' science and literacy skills. The Museum of London will be working with over 2000 schools in the South East to provide materials for the schools' own mini-museums on the Romans

  5. Family Day Care Provider Handbook

    ERIC Educational Resources Information Center

    New York State Office of Children and Family Services, 2006

    2006-01-01

    Family day care providers are responsible for creating a high-quality program where children have opportunities to grow, learn and thrive. Part of providing high-quality child care includes complying with the family day care regulations from the New York State Office of Children and Family Services (OCFS). This Handbook will help day care…

  6. Science Opportunities with LSST

    NASA Astrophysics Data System (ADS)

    Tyson, J. Anthony; Ivezic, Z.; Strauss, M.; LSST Science Collaborations

    2012-01-01

    The LSST design is driven by four science themes: dark energy and matter, Galactic structure, transient objects, and the Solar System inventory. These and many other science opportunities are described in the LSST Science Book: http://www.lsst.org/lsst/scibook The LSST will carry out a ten-year very deep imaging survey of 18,000 sq.deg. of the sky in six broad optical bands, with a deep stack reaching r 27.5 (5 sigma, point source). The LSST design, with an 8.4m (6.7m effective) primary mirror and a 9.6 square degree field of view, will allow about 10,000 square degrees of sky to be imaged to an effective depth of r=24.5 every three nights. Each patch of the sky will be visited over 800 times with pairs of 15 sec exposures, opening a new window on the universe: faint time-domain. The resulting petabytes of data will be made available to the US and Chilean communities for scientific investigations ranging from the properties of near-Earth asteroids, to characterizations of dark energy from strong and weak lensing, galaxy clustering, and distant supernovae. More information is available at http://www.lsst.org Eleven LSST Science Collaborations are actively laying the groundwork for first light: working on image analysis algorithms and database design, exploring cadence choices, developing commissioning plans, and outlining scientific opportunities. These Collaborations have over 200 members to date, with membership open to the US and Chilean communities via an application process administered by NOAO. Full end-to-end LSST image simulations are a useful resource for exploring science capability. LSST Science Collaborations: Supernovae Weak Lensing Stellar Populations Active Galactic Nuclei Solar System Galaxies Transients/variable stars Large-scale structure and baryon oscillations Milky Way and Local Volume Structure Strong Lensing Informatics and Statistics

  7. Closing the Windows on Opportunity.

    ERIC Educational Resources Information Center

    Coombs, Norman

    1995-01-01

    The rapid adoption of graphic user interface (GUI), as indicated by Microsoft's Windows95 and the Internet's increased use of graphics, is threatening information technology opportunities for people with disabilities. Recent legislation requires that schools provide access to computers and information technology, and producers of Mosaic are…

  8. Learning Opportunities for Older People.

    ERIC Educational Resources Information Center

    MacKeracher, Dorothy

    1980-01-01

    The author summarizes a conference on learning opportunities for older people by discussing six issues: (1) perspectives of older people and service providers; (2) categorization of older learners; (3) learning needs of older people; (4) participation rates; (5) government policies; and (6) curriculum concerns. (SK)

  9. Quantum Opportunities Program. A Brief on the QOP Pilot Program.

    ERIC Educational Resources Information Center

    Brandeis Univ., Waltham, MA. Center for Human Resources.

    The Quantum Opportunities Program (QOP) is an innovative 4-year year-round pilot program that provides learning opportunities, development opportunities, service opportunities, and summer jobs to small groups of youth from families receiving public assistance. In 1994, the Ford Foundation commissioned an evaluation of the QOP. Between 1989 and…

  10. Children with Special Needs in Family Day Care Homes: A Handbook of Approaches and Activities for Family Day Care Home Providers.

    ERIC Educational Resources Information Center

    de la Brosse, Beatrice

    Practical information and sample teaching activities for child caregivers who work with young developmentally disabled children in family day care settings are provided in this manual. Each chapter shares a typical experience a caregiver may have with a particular child. Chapter 1 focuses on getting to know a new child, initial expectations, and…

  11. Private Training Providers in Australia: Their Characteristics and Training Activities. A National Vocational Education and Training Research and Evaluation Program Report

    ERIC Educational Resources Information Center

    Harris, Roger; Simons, Michele; McCarthy, Carmel

    2006-01-01

    This study examines the nature of the training activity of private registered training organisations (RTOs) offered to Australian students in 2003, based on data from a national sample of 330 RTOs. The study also provides estimates of the private sector's overall contribution to the total vocational education and training (VET) effort in Australia…

  12. The Turn the Tables Technique (T[cube]): A Program Activity to Provide Group Facilitators Insight into Teen Sexual Behaviors and Beliefs

    ERIC Educational Resources Information Center

    Sclafane, Jamie Heather; Merves, Marni Loiacono; Rivera, Angelic; Long, Laura; Wilson, Ken; Bauman, Laurie J.

    2012-01-01

    The Turn the Tables Technique (T[cube]) is an activity designed to provide group facilitators who lead HIV/STI prevention and sexual health promotion programs with detailed and current information on teenagers' sexual behaviors and beliefs. This information can be used throughout a program to tailor content. Included is a detailed lesson plan of…

  13. Public Involvement in BOSC Activities

    EPA Pesticide Factsheets

    EPA policy and the Federal Advisory Committee Act provide for public involvement in committee activities primarily by open access to meetings and records and by providing the public an opportunity to submit comments to the committee.

  14. Critical technologies research: Opportunities for DOE

    SciTech Connect

    Not Available

    1992-12-01

    Recent studies have identified a number of critical technologies that are essential to the nation`s defense, economic competitiveness, energy independence, and betterment of public health. The National Critical Technologies Panel (NCTP) has identified the following critical technology areas: Aeronautics and Surface Transportation; Biotechnology and Life Sciences; Energy and Environment; Information and Communications; Manufacturing; and Materials. Sponsored by the Department of Energy`s Office of Energy Research (OER), the Critical Technologies Research Workshop was held in May 1992. Approximately 100 scientists, engineers, and managers from the national laboratories, industry, academia, and govemment participated. The objective of the Berkeley Workshop was to advance the role of the DOE multiprogram energy laboratories in critical technologies research by describing, defining, and illustrating research areas, opportunities, resources, and key decisions necessary to achieve national research goals. An agenda was developed that looked at DOE`s capabilities and options for research in critical technologies and provided a forum for industry, academia, govemment, and the national laboratories to address: Critical technology research needs; existing research activities and resources; capabilities of the national laboratories; and opportunities for national laboratories, industries, and universities. The Workshop included plenary sessions in which presentations by technology and policy leaders set the context for further inquiry into critical technology issues and research opportunities. Separate sessions then focused on each of the following major areas of technology: Advanced materials; biotechnology and life sciences; energy and environment; information and communication; and manufacturing and transportation.

  15. Critical technologies research: Opportunities for DOE

    SciTech Connect

    Not Available

    1992-12-01

    Recent studies have identified a number of critical technologies that are essential to the nation's defense, economic competitiveness, energy independence, and betterment of public health. The National Critical Technologies Panel (NCTP) has identified the following critical technology areas: Aeronautics and Surface Transportation; Biotechnology and Life Sciences; Energy and Environment; Information and Communications; Manufacturing; and Materials. Sponsored by the Department of Energy's Office of Energy Research (OER), the Critical Technologies Research Workshop was held in May 1992. Approximately 100 scientists, engineers, and managers from the national laboratories, industry, academia, and govemment participated. The objective of the Berkeley Workshop was to advance the role of the DOE multiprogram energy laboratories in critical technologies research by describing, defining, and illustrating research areas, opportunities, resources, and key decisions necessary to achieve national research goals. An agenda was developed that looked at DOE's capabilities and options for research in critical technologies and provided a forum for industry, academia, govemment, and the national laboratories to address: Critical technology research needs; existing research activities and resources; capabilities of the national laboratories; and opportunities for national laboratories, industries, and universities. The Workshop included plenary sessions in which presentations by technology and policy leaders set the context for further inquiry into critical technology issues and research opportunities. Separate sessions then focused on each of the following major areas of technology: Advanced materials; biotechnology and life sciences; energy and environment; information and communication; and manufacturing and transportation.

  16. Evolutionary constraints or opportunities?

    PubMed Central

    Sharov, Alexei A.

    2014-01-01

    Natural selection is traditionally viewed as a leading factor of evolution, whereas variation is assumed to be random and non-directional. Any order in variation is attributed to epigenetic or developmental constraints that can hinder the action of natural selection. In contrast I consider the positive role of epigenetic mechanisms in evolution because they provide organisms with opportunities for rapid adaptive change. Because the term “constraint” has negative connotations, I use the term “regulated variation” to emphasize the adaptive nature of phenotypic variation, which helps populations and species to survive and evolve in changing environments. The capacity to produce regulated variation is a phenotypic property, which is not described in the genome. Instead, the genome acts as a switchboard, where mostly random mutations switch “on” or “off” preexisting functional capacities of organism components. Thus, there are two channels of heredity: informational (genomic) and structure-functional (phenotypic). Functional capacities of organisms most likely emerged in a chain of modifications and combinations of more simple ancestral functions. The role of DNA has been to keep records of these changes (without describing the result) so that they can be reproduced in the following generations. Evolutionary opportunities include adjustments of individual functions, multitasking, connection between various components of an organism, and interaction between organisms. The adaptive nature of regulated variation can be explained by the differential success of lineages in macro-evolution. Lineages with more advantageous patterns of regulated variation are likely to produce more species and secure more resources (i.e., long-term lineage selection). PMID:24769155

  17. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

    PubMed Central

    Reiser, H; Freeman, G J; Razi-Wolf, Z; Gimmi, C D; Benacerraf, B; Nadler, L M

    1992-01-01

    We demonstrate that the murine B7 (mB7) protein is a potent costimulatory molecule for the activation of resting murine CD4+ T cells through the T-cell receptor (TCR)/CD3 complex. Stable mB7-transfected Chinese hamster ovary cells, but not vector-transfected controls, synergize with anti-CD3 monoclonal antibody and Con A-induced T-cell activation, resulting ultimately in proliferation. mB7 exerted its effect by inducing production of interleukin 2 and expression of the interleukin 2 receptor. Thus, mB7 costimulates T-cell activation through the TCR/CD3 complex by positively modulating the normal pathway of T-cell expansion. In contrast to the pronounced effect of mB7 on the activation of T cells through the TCR/CD3 complex, the mB7-transfected CHO cell line costimulated T-cell activation via the glycosylphosphatidylinositol-anchored proteins Thy-1 and Ly-6A.2 only inefficiently. Finally, the combination of a calcium ionophore and mB7 is not sufficient to cause T-cell proliferation, while the combination of a calcium ionophore and phorbol 12-myristate 13-acetate (PMA) stimulates T cells efficiently. The signals that mB7 and PMA provide for murine T lymphocyte activation are therefore not interchangeable, although both costimulate activation through the TCR/CD3 complex. Images PMID:1370349

  18. NASA's Flight Opportunities Program

    NASA Video Gallery

    NASA's Flight Opportunities Program is facilitating low-cost access to suborbital space, where researchers can test technologies using commercially developed vehicles. Suborbital flights can quickl...

  19. The Career Opportunities Program: A Summing Up.

    ERIC Educational Resources Information Center

    Carter, W. Thomas

    1976-01-01

    The Career Opportunities Program (COP), an initiative of the U.S. Office of Education, ended on June 30, 1976. COP attempted to provide opportunity for indigenous community residents working as paraprofessional teacher aides in the nation's low-income and rural schools to advance with the education profession through training and merit and,…

  20. EQUALITY OF EDUCATIONAL OPPORTUNITY.

    ERIC Educational Resources Information Center

    COLEMAN, JAMES S.; AND OTHERS

    THE PRODUCT OF AN EXTENSIVE SURVEY REQUESTED BY THE CIVIL RIGHTS ACT OF 1964, THIS REPORT DOCUMENTS THE AVAILABILITY OF EQUAL EDUCATIONAL OPPORTUNITIES IN THE PUBLIC SCHOOLS FOR MINORITY GROUP NEGROES, PUERTO RICANS, MEXICAN-AMERICANS, ORIENTAL-AMERICANS, AND AMERICAN INDIANS, AS COMPARED WITH OPPORTUNITIES FOR MAJORITY GROUP WHITES. COMPARATIVE…

  1. Office of Equal Opportunity Programs

    NASA Technical Reports Server (NTRS)

    Chin, Jennifer L.

    2004-01-01

    The NASA Glenn Office of Equal Opportunity Programs works to provide quality service for all programs and/or to assist the Center in becoming a model workplace. During the summer of 2004, I worked with Deborah Cotleur along with other staff members to create and modify customer satisfaction surveys. This office aims to assist in developing a model workplace by providing functions as a change agent to the center by serving as an advisor to management to ensure equity throughout the Center. In addition, the office serves as a mediator for the Center in addressing issues and concerns. Lastly, the office provides assistance to employees to enable attainment of personal and organizational goals. The Office of Equal Opportunities is a staff office which reports and provides advice to the Center Director and Executive Leadership, implements laws, regulations, and presidential executive orders, and provides center wide leadership and assistance to NASA GRC employees. Some of the major responsibilities of the office include working with the discrimination complaints program, special emphasis programs (advisory groups), management support, monitoring and evaluation, contract compliance, and community outreach. During my internship in this office, my main objective was to create four customer satisfaction surveys based on EO retreats, EO observances, EO advisory boards, and EO mediation/counseling. I created these surveys after conducting research on past events and surveys as well as similar survey research created and conducted by other NASA centers, program for EO Advisory group members, leadership training sessions for supervisors, preventing sexual harassment training sessions, and observance events. I also conducted research on the style and format from feedback surveys from the Marshall Equal Opportunity website, the Goddard website, and the main NASA website. Using the material from the Office of Equal Opportunity Programs at Glenn Research Center along with my

  2. American Indial Educational Opportunities Program at Hampton University

    NASA Technical Reports Server (NTRS)

    Molin, Paulette F.

    1999-01-01

    The American Indian Educational Opportunities Program (AIEOP) at Hampton University was formed to provide scholarship and other support to eligible students from state and federally recognized tribal groups on campus. During the reporting period, AIEOP worked to enhance American Indian participation at Hampton through a variety of means, including recruitment and retention of students, outreach activities, curatorial efforts, course instruction, and sponsorship of educational programs. Dr. Paulette F. Molin, a member of the Minnesota Chippewa Tribe, served as the program's director.

  3. Lunar Exploration and Science Opportunities in ESA

    NASA Astrophysics Data System (ADS)

    Carpenter, J.; Houdou, B.; Fisackerly, R.; De Rosa, D.; Schiemann, J.; Patti, B.; Foing, B.

    2014-04-01

    ESA seeks to provide Europe with access to the lunar surface, and allow Europeans to benefit from the opening up of this new frontier, as part of a global endeavour. This will be best achieved through an exploration programme which combines the strengths and capabilities of both robotic and human explorers. ESA is preparing for future participation in lunar exploration through a combination of human and robotic activities, in cooperation with international partners. Future planned activities include the contribution of key technological capabilities to the Russian led robotic missions, Luna-Glob, Luna-Resurs orbiter and Luna-Resurs lander. For the Luna-Resurs lander ESA will provide analytical capabilities to compliment the already selected Russian led payload, focusing on the composition and isotopic abundances of lunar volatiles in polar regions. This should be followed by the contributions at the level of mission elements to a Lunar Polar Sample Return mission. This partnership will provide access for European investigators to the opportunities offered by the Russian led instruments on the missions, as well as providing Europe with a unique opportunity to characterize and utilize polar volatile populations. Ultimately samples of high scientific value, from as of yet unexplored and unsampled locations shall be made available to the scientific community. These robotic activities are being performed with a view to enabling a future more comprehensive programme in which robotic and human activities are integrated to provide the maximum benefits from lunar surface access. Activities on the ISS and ESA participation to the US led Multi-Purpose Crew Vehicle, which is planned for a first unmanned lunar flight in 2017, are also important steps towards achieving this. All of these activities are performed with a view to generating the technologies, capabilities, knowledge and heritage that will make Europe an indispensible partner in the exploration missions of the future

  4. Undergraduate Educational Opportunity Programs.

    ERIC Educational Resources Information Center

    Valien, Preston

    The lack of financial resources is no longer seen as the only hurdle to be surmounted by the poor potential college student. The Upward Bound program was created in 1964 to provide cultural and educational activities during the summer for disadvantaged high school students. The Educational Talen t Search program began in 1965 as a supplement to…

  5. UTBB FDSOI: Evolution and opportunities

    NASA Astrophysics Data System (ADS)

    Monfray, Stephane; Skotnicki, Thomas

    2016-11-01

    As today's 28 nm FDSOI (Fully Depleted Silicon On Insulator) technology is at the industrialization level, this paper aims to summarize the key advantages allowed by the thin BOX (Buried Oxide) of the FDSOI, through the technology evolution but also new opportunities, among logic applications and extending the possibilities offered by the platform. We will summarize how the advantages provided by the thin BOX have been first explored and developed, and how the back biasing techniques are the key to the outstanding performances provided by the FDSOI at low voltage. Then, as the FDSOI technology is also a solution to develop innovative platforms and applications, we will detail some opportunities. In particular, we will present monolithic 3D integration, ultra-low power devices for IoT (Internet of Things) and ultra-sensitive sensors.

  6. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke

    PubMed Central

    Van Kanegan, Michael J.; Dunn, Denise E.; Kaltenbach, Linda S.; Shah, Bijal; He, Dong Ning; McCoy, Daniel D.; Yang, Peiying; Peng, Jiangnan; Shen, Li; Du, Lin; Cichewicz, Robert H.; Newman, Robert A.; Lo, Donald C.

    2016-01-01

    We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its principal cardiac glycoside constituent, oleandrin, via induction of the potent neurotrophic factor brain-derived neurotrophic factor (BDNF). However, we also noted that the concentration-relation for PBI-05204 in the brain slice oxygen-glucose deprivation (OGD) model is considerably broader than that for oleandrin as a single agent. We thus surmised that PBI-05204 contains an additional neuroprotective component(s), distinct from oleandrin. We report here that neuroprotective activity is also provided by the triterpenoid constituents of PBI-05204, notably oleanolic acid. We demonstrate that a sub-fraction of PBI-05204 (Fraction 0–4) containing oleanolic and other triterpenoids, but without cardiac glycosides, induces the expression of cellular antioxidant gene transcription programs regulated through antioxidant transcriptional response elements (AREs). Finally, we show that Fraction 0–4 provides broad neuroprotection in organotypic brain slice models for neurodegeneration driven by amyloid precursor protein (APP) and tau implicated in Alzheimer’s disease and frontotemporal dementias, respectively, in addition to ischemic injury modeled by OGD. PMID:27172999

  7. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

    PubMed

    Van Kanegan, Michael J; Dunn, Denise E; Kaltenbach, Linda S; Shah, Bijal; He, Dong Ning; McCoy, Daniel D; Yang, Peiying; Peng, Jiangnan; Shen, Li; Du, Lin; Cichewicz, Robert H; Newman, Robert A; Lo, Donald C

    2016-05-12

    We previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its principal cardiac glycoside constituent, oleandrin, via induction of the potent neurotrophic factor brain-derived neurotrophic factor (BDNF). However, we also noted that the concentration-relation for PBI-05204 in the brain slice oxygen-glucose deprivation (OGD) model is considerably broader than that for oleandrin as a single agent. We thus surmised that PBI-05204 contains an additional neuroprotective component(s), distinct from oleandrin. We report here that neuroprotective activity is also provided by the triterpenoid constituents of PBI-05204, notably oleanolic acid. We demonstrate that a sub-fraction of PBI-05204 (Fraction 0-4) containing oleanolic and other triterpenoids, but without cardiac glycosides, induces the expression of cellular antioxidant gene transcription programs regulated through antioxidant transcriptional response elements (AREs). Finally, we show that Fraction 0-4 provides broad neuroprotection in organotypic brain slice models for neurodegeneration driven by amyloid precursor protein (APP) and tau implicated in Alzheimer's disease and frontotemporal dementias, respectively, in addition to ischemic injury modeled by OGD.

  8. Cyberlearning for Climate Literacy: Challenges and Opportunities

    NASA Astrophysics Data System (ADS)

    McCaffrey, M. S.; Buhr, S. M.; Gold, A. U.; Ledley, T. S.; Mooney, M. E.; Niepold, F.

    2010-12-01

    Cyberlearning tools provide cost and carbon-efficient avenues for fostering a climate literate society through online engagement with learners. With climate change education becoming a Presidential Priority in 2009, funding for grants from NSF, NASA and NOAA is leading to a new generation of cyberlearning resources that supplement existing online resources. This paper provides an overview of challenges and opportunities relating to the online delivery of high quality, often complex climate science by examining several existing and emerging efforts, including the Climate Literacy and Energy Awareness Network (CLEAN,) a National Science Digital Library Pathway, the development by CIRES Education and Outreach of the Inspiring Climate Education Excellence (ICEE) online course, TERC’s Earth Exploration Toolbook (EET,) DataTools, and EarthLab modules, the NOAA Climate Stewards Education Program (CSEP) that utilizes the NSTA E-Learning Center, online efforts by members of the Federation of Earth Science Information Partners (ESIP), UCAR’s Climate Discovery program, and the Climate Adaptation, Mitigation e-Learning (CAMeL) project. In addition, we will summarize outcomes of the Cyberlearning for Climate Literacy workshop held in Washington DC in the Fall of 2009 and examine opportunities for teachers to develop and share their own lesson plans based on climate-related web resources that currently lack built-in learning activities, assessments or teaching tips.

  9. Impact of mild to severe hemophilia on engagement in recreational activities by US men, women, and children with hemophilia B: The Bridging Hemophilia B Experiences, Results and Opportunities into Solutions (B-HERO-S) study.

    PubMed

    Baumann, Kimberly; Hernandez, Grace; Witkop, Michelle; Peltier, Skye; Dunn, Spencer; Cutter, Susan; Frick, Neil; Haugstad, Kimberly; Guelcher, Christine; Frey, Mary Jane; Rotellini, Dawn; Clark, David B; Iyer, Neeraj N; Cooper, David L

    2017-04-01

    The psychosocial impact of hemophilia on activities was recently investigated in the Hemophilia Experiences, Results and Opportunities (HERO) study (675 people with hemophilia and 561 caregivers of children with hemophilia in 10 countries). The impact of hemophilia B may not be accurately reflected in the HERO results, as ~75% of respondents described issues affecting males with hemophilia A. To address the needs of this population, the Bridging Hemophilia B Experiences, Results and Opportunities Into Solutions (B-HERO-S) was developed as a pilot study in the United States in collaboration with the hemophilia community. The analysis reported here assessed engagement in recreational activities and changes to treatment regimens around activities as reported by 299 adults with hemophilia B and 150 caregivers of children with hemophilia B. Nearly all adults with hemophilia B (98%) experienced a negative impact on their participation in recreational activities due to hemophilia-related issues, and most caregivers (90%) reported that hemophilia B had a negative impact on their child's engagement in recreational activities. One of the main reasons identified for discontinuing past activities was the risk of bruising or bleeding (adults/children with hemophilia B, 49%/41%). In particular, adults with hemophilia B reported a history of activity-related bleeding, and most adults decreased their participation in high-risk activities as they aged. Substantial percentages of adults and children with hemophilia B (including mild/moderate severity) altered their treatment regimens to accommodate planned activities. These findings may help inform guidelines for individualizing treatment regimens around participation in recreational activities based on hemophilia severity, baseline factor level, and activity risk and intensity.

  10. Wind Technologies and Evolving Opportunities (Presentation)

    SciTech Connect

    Robi Robichaud

    2014-03-01

    This presentation provides an overview of wind energy research being conducted at the National Wind Technology Center, market and technology trends in wind energy, and opportunities for wind technology.

  11. Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia.

    PubMed

    Wang, Jianping; Yang, Zhitang; Liu, Cong; Zhao, Yuanzheng; Chen, Yibing

    2013-01-01

    Microglia are the major immune cells in the central nervous system and play a key role in brain injury pathology. However, the role of activated microglia after subacute cerebral ischemia (SCI) remains unknown. To address this issue, we established a permanent middle cerebral artery occlusion (pMCAO) rat model and treated pMCAO rats with N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide (PJ34) (an inhibitor of microglial activation), or with vehicle alone. Finally, we determined the differences between the PJ34-and vehicle-treated rats with respect to neurological deficits, infarct volume, neuronal loss and the expression of CD11b (a marker of microglial activation), glial cell line-derived neurotrophic factor (GDNF) and tumor necrosis factor-α (TNF-α) at 1, 3 and 7 days after treatment. We found that the PJ34-treated rats had more severe neurological deficits and a larger infarct volume and exhibited a decreased CD11b expression, more neuronal loss, decreased expression of GDNF mRNA and protein but increased expression of TNF-α mRNA and protein compared with the vehicle-treated rats at 3 and 7 days after treatment. These results indicate that activated microglia provide a neuroprotective role through balancing GDNF and TNF-α expression following SCI.

  12. Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.

    PubMed

    Borsato, Débora M; Prudente, Arthur S; Döll-Boscardin, Patrícia M; Borsato, Aurélio V; Luz, Cynthia F P; Maia, Beatriz H L N S; Cabrini, Daniela A; Otuki, Michel F; Miguel, Marilis D; Farago, Paulo V; Miguel, Obdulio G

    2014-07-01

    Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ± 5%. This extract decreased the myeloperoxidase activity in 75 ± 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ± 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.

  13. Providing Daily Oral Infection Control to Persons Dependent on others for Activities of Daily Living: A Semi-Qualitative Descriptive Study

    PubMed Central

    Wiener, R Constance; Dinsmore, Rebecca R; Meckstroth, Richard; Marshall, William

    2017-01-01

    Background The purpose of this study is to evaluate caregiver assessment of the ease of use of a specially designed toothbrush for providing daily oral infection control (toothbrushing) to persons dependent upon others for activities of daily living. Method Eighty-eight caregivers accepted surveys and multi-surface toothbrushes to provide daily oral infection control to the person to whom they assisted. They were asked to evaluate the ease of use of the multi-surface toothbrush, and provide comments about it. Results There were 30 surveys returned (34.1% response rate). In terms of the ease of use, 90.0% of the caregivers agreed (63.3% strongly agreed, and 26.7% agreed) that the multi-surface toothbrush was easier to use than their previous toothbrush. Comments about the toothbrush were predominantly positive. Conclusion It is difficult to provide daily oral infection control to another individual. Having an efficient oral health aid which makes it easier to do so is important to caregivers. With the overwhelming positive response to the multi-surface toothbrush, it is important to disseminate the information about its ease of use. PMID:28191548

  14. No Shortcut for Opportunity

    NASA Technical Reports Server (NTRS)

    2004-01-01

    As NASA's Mars Exploration Rover Opportunity was making its way back toward its original entry path into 'Endurance Crater,' scientists and engineers spotted what they hoped might be a shortcut for climbing out of the crater. The possible exit path, pictured on the far right of this image where the outcrop is punctuated, was eventually deemed too hazardous for the rover to attempt. Opportunity would have had to cross terrain with a slope of 28 degrees and face a tall rock outcropping very close to the exit chute opening which, itself, is too narrow for the rover to pass. This stereo view combines several frames taken by the rover's navigation camera during Opportunity's 297th sol on Mars (Nov. 24, 2004). It is presented in a cylindrical-perspective projection with geometric seam correction. The location from which the image was taken has been designated as Opportunity's Site 38, Position 97.

  15. Broadening Transfer Opportunities

    ERIC Educational Resources Information Center

    Dearing, Bruce

    1975-01-01

    Broadened opportunity for transfer offers a potential for bolstering sagging enrollments, and increases capacities for accomodating the educational needs of a broader spectrum of a democratic society. (Author/KE)

  16. School-to-Work Opportunities for All Youth: Intermediary Organizations and Expanding Options. School-to-Work Intermediary Project. Issue Brief.

    ERIC Educational Resources Information Center

    Spera, Vincent; Williams, Andra

    The School to Work Opportunities Act of 1994 requires that all young people, including young people with disabilities and out-of-school youth, have equal opportunities to participate in the activities funded by it. Local intermediary organizations that provide a critical convening role and offer services to core education and business partners can…

  17. 13 CFR 125.17 - Who decides if a contract opportunity for SDVO competition exists?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... opportunity for SDVO competition exists? 125.17 Section 125.17 Business Credit and Assistance SMALL BUSINESS... opportunity for SDVO competition exists? The contracting officer for the contracting activity decides if a contract opportunity for SDVO competition exists....

  18. 13 CFR 125.17 - Who decides if a contract opportunity for SDVO competition exists?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... opportunity for SDVO competition exists? 125.17 Section 125.17 Business Credit and Assistance SMALL BUSINESS... opportunity for SDVO competition exists? The contracting officer for the contracting activity decides if a contract opportunity for SDVO competition exists....

  19. 13 CFR 125.17 - Who decides if a contract opportunity for SDVO competition exists?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... opportunity for SDVO competition exists? 125.17 Section 125.17 Business Credit and Assistance SMALL BUSINESS... opportunity for SDVO competition exists? The contracting officer for the contracting activity decides if a contract opportunity for SDVO competition exists....

  20. 13 CFR 125.17 - Who decides if a contract opportunity for SDVO competition exists?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... opportunity for SDVO competition exists? 125.17 Section 125.17 Business Credit and Assistance SMALL BUSINESS... opportunity for SDVO competition exists? The contracting officer for the contracting activity decides if a contract opportunity for SDVO competition exists....

  1. Pollution prevention opportunity assessments at Hanford

    SciTech Connect

    Betsch, M.D., Westinghouse Hanford

    1996-06-26

    The Pollution Prevention Opportunity Assessment (PPOA) is a pro- active way to look at a waste generating activity and identify opportunities to minimize wastes through a cost benefit analysis. Hanford`s PPOA process is based upon the graded approach developed by the Kansas City Plant. Hanford further streamlined the process while building in more flexibility for the individual users. One of the most challenging aspects for implementing the PPOA process at Hanford is one overall mission which is environmental restoration, Now that the facilities are no longer in production, each has a different non- routine activity making it difficult to quantify the inputs and outputs of the activity under consideration.

  2. 10 CFR 1040.8 - Effect of employment opportunity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Effect of employment opportunity. 1040.8 Section 1040.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR ACTIVITIES General Provisions § 1040.8 Effect of employment opportunity. Due to limited opportunities in...

  3. 10 CFR 1040.8 - Effect of employment opportunity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Effect of employment opportunity. 1040.8 Section 1040.8 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR ACTIVITIES General Provisions § 1040.8 Effect of employment opportunity. Due to limited opportunities in...

  4. A new UK Greenhouse Gas measurement network providing ultra high-frequency measurements of key radiatively active trace gases taken from a network of tall towers

    NASA Astrophysics Data System (ADS)

    Grant, A.; O'Doherty, S.; Manning, A. J.; Simmonds, P. G.; Derwent, R. G.; Moncrieff, J. B.; Sturges, W. T.

    2012-04-01

    Monitoring of atmospheric concentrations of gases is important in assessing the impact of international policies related to the atmospheric environment. The effects of control measures on greenhouse gases introduced under the Montreal and Kyoto Protocols are now being observed. Continued monitoring is required to assess the overall success of the Protocols. For over 15 years the UK Government have funded high-frequency measurements of greenhouse gases and ozone depleting gases at Mace Head, a global background measurement station on the west coast of Ireland. These continuous, high-frequency, high-precision measurements are used to estimate regional (country-scale) emissions of greenhouse gases across the UK using an inversion methodology (NAME-Inversion) that links the Met Office atmospheric dispersion model (Numerical Atmospheric dispersion Modelling Environment - NAME) with the Mace Head observations. This unique inversion method acts to independently verify bottom up emission estimates of radiatively active and ozone-depleting trace gases. In 2011 the UK government (DECC) funded the establishment and integration of three new tall tower measurements stations in the UK, to provide enhanced resolution emission maps and decrease uncertainty of regional emission estimates produced using the NAME-Inversion. One station included in this new UK network was already established in Scotland and was used in collaboration with Edinburgh University. The two other new stations are in England and were set-up early in 2012, they contain brand new instrumentation for measurements of greenhouse gases. All three additional stations provide ultra high-frequency (1 sec) data of CO2 and CH4 using the Picarro© Cavity Ring Down Spectrometer and high frequency (20 min) measurements of N2O and SF6 from custom built sample modules with GC-ECD. We will present the new tall tower UK measurement network in detail. Using high-frequency measurements at new operational sites, including Mace

  5. HIV testing among sexually active Hispanic/Latino MSM in Miami-Dade County and New York City: opportunities for increasing acceptance and frequency of testing.

    PubMed

    Joseph, Heather A; Belcher, Lisa; O'Donnell, Lydia; Fernandez, M Isabel; Spikes, Pilgrim S; Flores, Stephen A

    2014-11-01

    HIV testing behavior is important in understanding the high rates of undiagnosed infection among Hispanic/Latino men who have sex with men (MSM). Correlates of repeat/recent testing (within the past year and ≥5 tests during lifetime) and test avoidance (never or >5 years earlier) were examined among 608 sexually active Hispanic/Latino MSM (Miami-Dade County and New York City). Those who reported repeat/recent testing were more likely to have incomes over $30,000, speak English predominately, and have visited and disclosed same-sex behavior to a health care provider (HCP) in the past year. Those who were classified as test avoiders were less likely to have incomes over $10,000 and to have seen an HCP in the past year. The main reason for not testing (in both groups) was fear of HIV positivity; however, twice as many test avoiders considered this their main reason, and more test avoiders had confidentiality concerns. Results suggest that messages to encourage testing among Hispanic/Latino MSM may be most effective if past testing patterns and reasons for not testing are considered. HCPs can play an important role by consistently offering HIV tests to MSM and tailoring messages based on prior testing histories.

  6. Postsecondary Education Opportunity. The Mortenson Report on Public Policy Analysis of Opportunity for Postsecondary Education, 1995.

    ERIC Educational Resources Information Center

    Mortenson, Thomas G., Ed.

    1995-01-01

    This document is a collection of 12 issues of a monthly publication on public policy and postsecondary education opportunity. Each issue contains one or two main articles providing an analysis of research on trends in postsecondary education. The major articles in these issues are: (1) "The Challenge of Educational Opportunity in Public…

  7. Seattle Opportunities Industrialization Center. Final Report.

    ERIC Educational Resources Information Center

    Opportunities Industrialization Center, Inc., Seattle, WA.

    The goals of the Opportunities Industrialization Center organization in Seattle include providing hope for impoverished and hard-core unemployed in the form of job preparation by providing adult education, pre-vocational training, skills training, counseling, job development, placement and followup. Another primary goal of OIC is providing and…

  8. 21. Providence & Worchester RR: Freight house. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Providence & Worchester RR: Freight house. Providence, Providence Co., RI. Sec. 4119, mp 185.66 (See HAER no. RI-3 for further documentation on this site.) - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  9. Structure and Activity Analyses of Escherichia coli K-12 NagD Provide Insight into the Evolution of Biochemical Function in the Haloakanoic Acid Dehlogenase Superfamily

    SciTech Connect

    Tremblay,L.; Dunaway-Mariano, D.; Allen, K.

    2006-01-01

    The HAD superfamily is a large superfamily of proteins which share a conserved core domain that provides those active site residues responsible for the chemistry common to all family members. The superfamily is further divided into the four subfamilies I, IIA, IIB, and III, based on the topology and insertion site of a cap domain that provides substrate specificity. This structural and functional division implies that members of a given HAD structural subclass may target substrates that have similar structural characteristics. To understand the structure/function relationships in all of the subfamilies, a type IIA subfamily member, NagD from Escherichia coli K-12, was selected (type I, IIB, and III members have been more extensively studied). The structure of the NagD protein was solved to 1.80 Angstroms with R{sub work} = 19.8% and R{sub free} = 21.8%. Substrate screening and kinetic analysis showed NagD to have high specificity for nucleotide monophosphates with kcat/Km = 3.12 x 10{sup 4} and 1.28 x 10{sup 4} {micro}M{sup -1} s{sup -1} for UMP and GMP, respectively. This specificity is consistent with the presence of analogues of NagD that exist as fusion proteins with a nucleotide pyrophosphatase from the Nudix family. Docking of the nucleoside substrate in the active site brings it in contact with conserved residues from the cap domain that can act as a substrate specificity loop (NagD residues 144-149) in the type IIA subfamily. NagD and other subfamily IIA and IIB members show the common trait that substrate specificity and catalytic efficiencies (k{sub cat}/K{sub m}) are low (1 x 10{sup 4} M{sup -1} s{sup -1}) and the boundaries defining physiological substrates are somewhat overlapping. The ability to catabolize other related secondary metabolites indicates that there is regulation at the genetic level.

  10. Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily.

    PubMed

    Tremblay, Lee W; Dunaway-Mariano, Debra; Allen, Karen N

    2006-01-31

    The HAD superfamily is a large superfamily of proteins which share a conserved core domain that provides those active site residues responsible for the chemistry common to all family members. The superfamily is further divided into the four subfamilies I, IIA, IIB, and III, based on the topology and insertion site of a cap domain that provides substrate specificity. This structural and functional division implies that members of a given HAD structural subclass may target substrates that have similar structural characteristics. To understand the structure/function relationships in all of the subfamilies, a type IIA subfamily member, NagD from Escherichia coli K-12, was selected (type I, IIB, and III members have been more extensively studied). The structure of the NagD protein was solved to 1.80 A with R(work) = 19.8% and R(free) = 21.8%. Substrate screening and kinetic analysis showed NagD to have high specificity for nucleotide monophosphates with k(cat)/K(m) = 3.12 x 10(4) and 1.28 x 10(4) microM(-)(1) s(-)(1) for UMP and GMP, respectively. This specificity is consistent with the presence of analogues of NagD that exist as fusion proteins with a nucleotide pyrophosphatase from the Nudix family. Docking of the nucleoside substrate in the active site brings it in contact with conserved residues from the cap domain that can act as a substrate specificity loop (NagD residues 144-149) in the type IIA subfamily. NagD and other subfamily IIA and IIB members show the common trait that substrate specificity and catalytic efficiencies (k(cat)/K(m)) are low (1 x 10(4) M(-)(1) s(-)(1)) and the boundaries defining physiological substrates are somewhat overlapping. The ability to catabolize other related secondary metabolites indicates that there is regulation at the genetic level.

  11. A European Network of Email and Telephone Help Lines Providing Information and Support on Rare Diseases: Results From a 1-Month Activity Survey

    PubMed Central

    Sanchez de Vega, Rosa; Brignol, Tuy Nga; Mazzucato, Monica; Polizzi, Agata

    2014-01-01

    Background Information on rare diseases are often complex to understand, or difficult to access and additional support is often necessary. Rare diseases helplines work together across Europe to respond to calls and emails from the public at large, including patients, health care professionals, families, and students. Measuring the activity of helplines can help decision makers to allocate adequate funds when deciding to create or expand an equivalent service. Objective Data presented are referred to a monthly user profile analysis, which is one of the activities that each helpline has to carry out to be part of the network. This survey aimed to explore the information requests and characteristics of users of rare diseases helplines in different European countries. Another aim was to analyze these data with respect to users’ characteristics, helpline characteristics, topics of the inquiries, and technologies used to provide information. With this survey, we measure data that are key for planning information services on rare diseases in the context of the development of national plans for rare diseases. Methods A survey was conducted based on all calls, emails, visits, or letters received from November 1 to 30, 2012 to monitor the activity represented by 12 helplines. Data were collected by a common standardized form, using ORPHA Codes for rare diseases, when applicable. No personal data identifying the inquirer were collected. It was a descriptive approach documenting on the number and purpose of inquiries, the number of respondents, the mode of contact, the category of the inquirer in relation to the patient, the inquirer’s gender, age and region of residence, the patient’s age when applicable, the type and duration of response, and the satisfaction as scored by the respondents. Results A total of 1676 calls, emails, or letters were received from November 1 to 30, 2012. Inquiries were mostly about specific diseases. An average of 23 minutes was spent for each

  12. Opportunities for NASA Aerospace Related Funding and Collaboration

    NASA Technical Reports Server (NTRS)

    Miranda, Felix A.

    2005-01-01

    This presentation describes the different opportunities that NASA offers for effective collaboration with Academia and Industry. In particular, the presentation includes a general overview of opportunities such as SBIRs, STTRs, Educational Programs and NASA Research Announcements. A general description of forthcoming competitive opportunities under the Exploration Systems Mission Directorate (ESMD) as well as the Science Mission Directorate (SMD) are also provided.

  13. 29 CFR 30.3 - Equal opportunity standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Equal opportunity standards. 30.3 Section 30.3 Labor Office of the Secretary of Labor EQUAL EMPLOYMENT OPPORTUNITY IN APPRENTICESHIP AND TRAINING § 30.3 Equal... the program sponsor; and (3) Take affirmative action to provide equal opportunity in...

  14. 29 CFR 30.3 - Equal opportunity standards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Equal opportunity standards. 30.3 Section 30.3 Labor Office of the Secretary of Labor EQUAL EMPLOYMENT OPPORTUNITY IN APPRENTICESHIP AND TRAINING § 30.3 Equal... the program sponsor; and (3) Take affirmative action to provide equal opportunity in...

  15. 29 CFR 30.3 - Equal opportunity standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Equal opportunity standards. 30.3 Section 30.3 Labor Office of the Secretary of Labor EQUAL EMPLOYMENT OPPORTUNITY IN APPRENTICESHIP AND TRAINING § 30.3 Equal... the program sponsor; and (3) Take affirmative action to provide equal opportunity in...

  16. 29 CFR 30.3 - Equal opportunity standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Equal opportunity standards. 30.3 Section 30.3 Labor Office of the Secretary of Labor EQUAL EMPLOYMENT OPPORTUNITY IN APPRENTICESHIP AND TRAINING § 30.3 Equal... the program sponsor; and (3) Take affirmative action to provide equal opportunity in...

  17. Single concentration loss of activity assay provides an improved assessment of drug-drug interaction risk compared to IC50-shift.

    PubMed

    Wong, Simon G; Lee, Mey; Wong, Bradley K

    2016-11-01

    1. The utility of two abbreviated, higher-throughput assays [IC50-shift and the loss of activity (LOA) assay] to evaluate time-dependent inhibition (TDI) of 24 structurally related compounds was compared. 2. Good correlation (R(2)  = 0.90) between % inhibition and kinact/KI suggested that the LOA assay has utility as an indicator of TDI potential. Weaker correlation was observed for the shifted IC50 (IC50(T = 30)) (R(2) = 0.61) and the fold-shift in IC50 (R(2) = 0.17). 3. Primary mechanism for poor correlation was depletion of active enzyme at concentrations > 1 μM leading to greater than predicted inhibition in the IC50-shift assay. 4. Previously reported strong correlations between IC50(T = 30) and kinact/KI were found to be dependent on potent TDI compounds with kinact/KI > 30; correlation was reduced for moderate inhibitors (kinact/KI < 30). LOA assay maintained good correlation even when strong TDI compounds were excluded. 5. LOA assay (% Inhibition at 30 min, 10 μM) was a good predictor of in vivo DDI (AUCr), providing a graded response with low potential for false negatives or positives. IC50-shift assay had bias for over-predicting in vivo DDI and was more likely to identify false positives.

  18. Low-dose ionizing radiation induces direct activation of natural killer cells and provides a novel approach for adoptive cellular immunotherapy.

    PubMed

    Yang, Guozi; Kong, Qingyu; Wang, Guanjun; Jin, Haofan; Zhou, Lei; Yu, Dehai; Niu, Chao; Han, Wei; Li, Wei; Cui, Jiuwei

    2014-12-01

    Recent evidence indicates that limited availability and cytotoxicity have restricted the development of natural killer (NK) cells in adoptive cellular immunotherapy (ACI). While it has been reported that low-dose ionizing radiation (LDIR) could enhance the immune response in animal studies, the influence of LDIR at the cellular level has been less well defined. In this study, the authors aim to investigate the direct effects of LDIR on NK cells and the potential mechanism, and explore the application of activation and expansion of NK cells by LDIR in ACI. The authors found that expansion and cytotoxicity of NK cells were markedly augmented by LDIR. The levels of IFN-γ and TNF-α in the supernatants of cultured NK cells were significantly increased after LDIR. Additionally, the effect of the P38 inhibitor (SB203580) significantly decreased the expanded NK cell cytotoxicity, cytokine levels, and expression levels of FasL and perforin. These findings indicate that LDIR induces a direct expansion and activation of NK cells through possibly the P38-MAPK pathway, which provides a potential mechanism for stimulation of NK cells by LDIR and a novel but simplified approach for ACI.

  19. Opportunity's Heat Shield Scene

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This image from NASA's Mars Exploration Rover Opportunity reveals the scene of the rover's heat shield impact. In this view, Opportunity is approximately 130 meters (427 feet) away from the device that protected it while hurtling through the martian atmosphere.

    The rover spent 36 sols investigating how the severe heating during entry through the atmosphere affected the heat shield. The most obvious is the fact that the heat shield inverted upon impact.

    This is the panoramic camera team's best current attempt at generating a true-color view of what this scene would look like if viewed by a human on Mars. It was generated from a mathematical combination of six calibrated, left-eye panoramic camera images acquired around 1:50 p.m. local solar time on Opportunity's sol 322 (Dec. 19, 2004) using filters ranging in wavelengths from 430 to 750 nanometers.

  20. Overview of Space Science and Information Research Opportunities at NASA

    NASA Technical Reports Server (NTRS)

    Green, James L.

    2000-01-01

    It is not possible to review all the opportunities that NASA provides to support the Space Science Enterprise, in the short amount of time allotted for this presentation. Therefore, only a few key programs will be discussed. The programs that I will discuss will concentrate on research opportunities for faculty, graduate and postdoctoral candidates in Space Science research and information technologies at NASA. One of the most important programs for research opportunities is the NASA Research Announcement or NRA. NASA Headquarters issues NRA's on a regular basis and these cover space science and computer science activities relating to NASA missions and programs. In the Space Sciences, the most important NRA is called the "Research Opportunities in Space Science or the ROSS NRA. The ROSS NRA is composed of multiple announcements in the areas of structure and evolution of the Universe, Solar System exploration, Sun-Earth connections, and applied information systems. Another important opportunity is the Graduate Student Research Program (GSRP). The GSRP is designed to cultivate research ties between a NASA Center and the academic community through the award of fellowships to promising students in science and engineering. This program is unique since it matches the student's area of research interest with existing work being carried out at NASA. This program is for U.S. citizens who are full-time graduate students. Students who are successful have made the match between their research and the NASA employee who will act as their NASA Advisor/ Mentor. In this program, the student's research is primarily accomplished under the supervision of his faculty advisor with periodic or frequent interactions with the NASA Mentor. These interactions typically involve travel to the sponsoring NASA Center on a regular basis. The one-year fellowships are renewable for up to three years and over $20,000 per year. These and other important opportunities will be discussed.

  1. Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.

    PubMed

    Garcia, Khristofer; Blank, Jonathan L; Bouck, David C; Liu, Xiaozhen J; Sappal, Darshan S; Hather, Greg; Cosmopoulos, Katherine; Thomas, Michael P; Kuranda, Mike; Pickard, Michael D; Liu, Ray; Bandi, Syamala; Smith, Peter G; Lightcap, Eric S

    2014-06-01

    MLN4924 is an investigational small-molecule inhibitor of the Nedd8-activating enzyme currently in phase I clinical trials. MLN4924 induces DNA damage via rereplication in most cell lines. This distinct mechanism of DNA damage may affect its ability to combine with standard-of-care agents and may affect the clinical development of MLN4924. As such, we studied its interaction with other DNA-damaging agents. Mitomycin C, cisplatin, cytarabine, UV radiation, SN-38, and gemcitabine demonstrated synergy in combination with MLN4924 in vitro. The combination of mitomycin C and MLN4924 was shown to be synergistic in a mouse xenograft model. Importantly, depletion of genes within the ataxia telangiectasia and Rad3 related (ATR) and BRCA1/BRCA2 pathways, chromatin modification, and transcription-coupled repair reduced the synergy between mitomycin C and MLN4924. In addition, comet assay demonstrated increased DNA strand breaks with the combination of MLN4924 and mitomycin C. Our data suggest that mitomycin C causes stalled replication forks, which when combined with rereplication induced by MLN4924 results in frequent replication fork collisions, leading to cell death. This study provides a straightforward approach to understand the mechanism of synergy, which may provide useful information for the clinical development of these combinations.

  2. Recent Opportunity Microscopic Imager Results

    NASA Astrophysics Data System (ADS)

    Herkenhoff, K. E.; Arvidson, R. E.; Jolliff, B. L.; Yingst, R.; Team, A.

    2013-12-01

    Opportunity. The extremely soft bedrock exposed at a Whitewater Lake outcrop target dubbed 'Azilda' is mostly fine-grained, with dispersed 2-5 mm-diameter spherules and resistant veins. This target was easily abraded by the RAT, exposing a sandstone-like texture, but the sorting of grains is difficult to determine at MI resolution. Darker, erosion-resistant veneers, similar to desert varnishes on Earth, appear to record aqueous alteration that post-dates the formation of the Ca sulfate veins; they likely contain the nontronite that is observed by CRISM in this area. The inferred neutral pH and relatively low temperature of the fluids involved in these phases of alteration would have provided a habitable environment for life if it existed on Mars at that time. Because Opportunity can no longer directly sense phyllosilicate mineralogy with the MiniTES or Mössbauer spectrometers, it is focusing on characterizing the chemistry with the APXS and texture with the MI of potential phyllosilicate host rocks. The Athena MI continues to return useful images of Mars that are being used to study the textures of rocks and soils at Endeavour crater. Exploration by Opportunity continues, with the rover approaching 'Solander Point' and more exposures of phyllosilicates detected from orbit; the latest MI results will be presented at the conference.

  3. The central equipment pool, an opportunity for improved technology management.

    PubMed

    Gentles, W M

    2000-01-01

    A model for a central equipment pool managed by a clinical engineering department has been presented. The advantages to patient care and to the clinical engineering department are many. The distribution of portable technology that has been traditionally managed by the materials management function is a logical match to the expanding role of clinical engineering departments in technology management. Accurate asset management tools have allowed us to provide reliable measures of infusion pump utilization, permitting us to predict future needs as programs expand. Thus we are more actively involved in strategic technology planning. The central equipment pool is an excellent opportunity for the clinical engineering department to increase its technology management activities.

  4. Opportunity's Empty Nest

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image taken by the panoramic camera onboard the Mars Exploration Rover Opportunity shows the rover's now-empty lander, the Challenger Memorial Station, at Meridiani Planum, Mars. The image was acquired on the 24th martian day, or sol, of Opportunity's mission at approximately 13:00 Local Solar Time. This is a mosaic image consisting of 12 color images acquired with the camera's red, green and blue filters. The color balance has been set to approximate the colors that a human eye would see.

  5. Opportunity Rocks Again!

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This high-resolution image captured by the Mars Exploration Rover Opportunity's panoramic camera highlights a portion of the puzzling rock outcropping that scientists eagerly wait to investigate. Presently, Opportunity is on its lander facing northeast; the outcropping lies to the northwest. These layered rocks measure only 10 centimeters (4 inches) tall and are thought to be either volcanic ash deposits or sediments carried by water or wind. Data from the panoramic camera's near-infrared, blue and green filters were combined to create this approximate true color image.

  6. Decadal opportunities for space architects

    NASA Astrophysics Data System (ADS)

    Sherwood, Brent

    2012-12-01

    A significant challenge for the new field of space architecture is the dearth of project opportunities. Yet every year more young professionals express interest to enter the field. This paper derives projections that bound the number, type, and range of global development opportunities that may be reasonably expected over the next few decades for human space flight (HSF) systems so those interested in the field can benchmark their goals. Four categories of HSF activity are described: human Exploration of solar system bodies; human Servicing of space-based assets; large-scale development of space Resources; and Breakout of self-sustaining human societies into the solar system. A progressive sequence of capabilities for each category starts with its earliest feasible missions and leads toward its full expression. The four sequences are compared in scale, distance from Earth, and readiness. Scenarios hybridize the most synergistic features from the four sequences for comparison to status quo, government-funded HSF program plans. Finally qualitative, decadal, order-of-magnitude estimates are derived for system development needs, and hence opportunities for space architects. Government investment towards human planetary exploration is the weakest generator of space architecture work. Conversely, the strongest generator is a combination of three market drivers: (1) commercial passenger travel in low Earth orbit; (2) in parallel, government extension of HSF capability to GEO; both followed by (3) scale-up demonstration of end-to-end solar power satellites in GEO. The rich end of this scale affords space architecture opportunities which are more diverse, complex, large-scale, and sociologically challenging than traditional exploration vehicle cabins and habitats.

  7. New drug discovery: extraordinary opportunities in an uncertain time.

    PubMed

    Kinch, Michael S; Flath, Richard

    2015-11-01

    The way in which new medicines are discovered has irreversibly changed and the future sustainability of the enterprise is characterized by an unprecedented period of uncertainty. Herein, we convey that these changes provide unprecedented opportunities for many different players within the private and public sectors to work together and develop new models that ensure the sustainability of activities that have had an extraordinary impact; in terms of promoting public health and driving economic value. Specific examples of experiments are provided to demonstrate some of the new thinking that will be needed to ensure continuation of new drug discovery.

  8. Genome-scale metabolic modeling to provide insight into the production of storage compounds during feast-famine cycles of activated sludge.

    PubMed

    Tajparast, Mohammad; Frigon, Dominic

    2013-01-01

    Studying storage metabolism during feast-famine cycles of activated sludge treatment systems provides profound insight in terms of both operational issues (e.g., foaming and bulking) and process optimization for the production of value added by-products (e.g., bioplastics). We examined the storage metabolism (including poly-β-hydroxybutyrate [PHB], glycogen, and triacylglycerols [TAGs]) during feast-famine cycles using two genome-scale metabolic models: Rhodococcus jostii RHA1 (iMT1174) and Escherichia coli K-12 (iAF1260) for growth on glucose, acetate, and succinate. The goal was to develop the proper objective function (OF) for the prediction of the main storage compound produced in activated sludge for given feast-famine cycle conditions. For the flux balance analysis, combinations of three OFs were tested. For all of them, the main OF was to maximize growth rates. Two additional sub-OFs were used: (1) minimization of biochemical fluxes, and (2) minimization of metabolic adjustments (MoMA) between the feast and famine periods. All (sub-)OFs predicted identical substrate-storage associations for the feast-famine growth of the above-mentioned metabolic models on a given substrate when glucose and acetate were set as sole carbon sources (i.e., glucose-glycogen and acetate-PHB), in agreement with experimental observations. However, in the case of succinate as substrate, the predictions depended on the network structure of the metabolic models such that the E. coli model predicted glycogen accumulation and the R. jostii model predicted PHB accumulation. While the accumulation of both PHB and glycogen was observed experimentally, PHB showed higher dynamics during an activated sludge feast-famine growth cycle with succinate as substrate. These results suggest that new modeling insights between metabolic predictions and population ecology will be necessary to properly predict metabolisms likely to emerge within the niches of activated sludge communities. Nonetheless

  9. Target of Opportunity: New Transiting Exoplanets

    NASA Astrophysics Data System (ADS)

    Harrington, Joseph; Bakos, Gaspar; Deming, Drake; Fischer, Debra; Seager, Sara; Wheatley, Peter

    2007-05-01

    We propose a Target of Opportunity (ToO) program to observe eclipses of new extrasolar planets. The measured band fluxes constrain models of composition, chemistry, and atmospheric dynamics. They also provide the basic information needed for follow-on work. Since the spacecraft is nearing the end of its limited lifetime, rapid characterization is crucial. Well below Spitzer's nominal sensitivity, these measurements are challenging, and optimized observing and analysis techniques that are not obvious are required to bring in the best signal. Many Discretionary Time proposals have been approved on this topic. Our goals, achieved with our Cycle-3 ToO program and continued here, are to ensure that each bandpass is observed for every planet with good predicted S/N, to obtain the best possible observations, to make these high-impact data public for everyone to use in planning followups, and to make the process of observing exoplanets smooth for observers and Spitzer by allocating a predictable number of events for the community through the TAC process. Based on actual discovery statistics and the known quantities of survey data in hand, we confidently predict about 22 new transiting-planet announcements in the coming year. Of these, one may be bright enough to measure in six bandpasses, and several may be marginal for Spitzer. We thus request 120 hours to cover about 18 6:40-hour eclipse events in low-impact ToOs. We provide quantitative criteria for activating ToOs. Our archival product will be calibrated lightcurves, to be submitted as electronic attachments with journal articles. Transiting extrasolar planets are among the least anticipated and most productive targets for Spitzer. They are also among the most publicly stimulating. These direct measurements provide the only emission fluxes possible with current telescopes for extrasolar planets, and stand as a Spitzer legacy for posterity. The next opportunity to observe them is with JWST.

  10. Summer Opportunities for Students.

    ERIC Educational Resources Information Center

    Winds of Change, 2003

    2003-01-01

    Eleven summer internships, work experience programs, research opportunities, and courses are described. Some offer stipends. Some are specifically for American Indian, minority, disadvantaged, or disabled students in high school or college. Most are in science or engineering related fields. Each entry contains a brief program description,…

  11. Demographic Problems and Opportunities.

    ERIC Educational Resources Information Center

    Osborn, Frances P.

    A comparison of Monroe County projections of high school graduates and the March 1986 Rochester Labor Area Summary points to some excellent opportunities for marketing Monroe Community College (MCC). Projections of high school graduation rates show a 25% decrease in the number of graduates between 1989 and 1991, while the demand for entry-level…

  12. Opportunity Cost: A Reply

    ERIC Educational Resources Information Center

    Parkin, Michael

    2016-01-01

    The author's objective for this reply in reexamining opportunity cost was to draw attention to two conflicting definitions of the concept in current use and to argue the case for dropping one of them. The comments of Daniel Arce, Rod O'Donnell, and Daniel Stone might be read as demonstration that the author has failed on both counts. Such a…

  13. Opportunities and progress.

    PubMed

    Litchfield, John H

    2014-01-01

    In this review, I cover my professional experiences in food science and technology and related areas of applied and industrial microbiology over the span of my career. It emphasizes opportunities and technological problems that I encountered together with my progress in follow-up development of products and processes.

  14. The Promise of Opportunity

    ERIC Educational Resources Information Center

    Kerry, John F.

    2004-01-01

    In this article, the author argues that now as never before, education is the key to opportunity, essential to a strong America. In an age when people compete with workers on every continent and information flows across oceans, high-wage jobs are more dependent than ever on high-level skills. The author suggests that together, an America that…

  15. Equal Educational Opportunity?

    ERIC Educational Resources Information Center

    Morris, Lorenzo

    1980-01-01

    Holds that the "Bakke" decision simply reaffirmed an insufficient commitment to equal opportunities for Blacks in higher education. Reviews several studies, including research conducted at the Institute for the Study of Educational Policy (ISEP) that has focused on the social and economic context of educational discrimination. (GC)

  16. EERE Financial Opportunities

    SciTech Connect

    2012-04-19

    The Office of Energy Efficiency and Renewable Energy (EERE) works with business, industry, universities, and others to increase the use of renewable energy and energy efficiency technologies. One way EERE encourages the growth of these technologies is by offering financial assistance opportunities for their development and demonstration.

  17. Window of Opportunity.

    ERIC Educational Resources Information Center

    Gingrich, Newt

    1985-01-01

    Advances in space, communications, and biotechnology are creating many opportunities and hope for the future. But to take full advantage of these technological breakthroughs, the United States must rethink its approaches to education, welfare, health, justice, and defense. (Author/RM)

  18. Equal Opportunity in Employment

    ERIC Educational Resources Information Center

    Bullock, Paul

    This book focuses on discrimination in employment, defined as the denial of equal opportunity in the labor market to qualified persons on the basis of race, color, religion, national origin, age, sex, or any other factor not related to their individual qualifications for work. The average nonwhite college graduate can expect to earn less during…

  19. Opportunity Turns 40

    ERIC Educational Resources Information Center

    Muccio, Maria; Pierre-Vil, Samienta

    2016-01-01

    The New England Educational Opportunity Association (NEOA) drew more than 250 TRIO and college access professionals to its 40th annual conference in Massachusetts earlier this spring. NEOA's mission is to advocate for access to and success in postsecondary education for low-income individuals, "first-generation" college students, and…

  20. J. Sargeant Reynolds Community College Narrative Report: Urban Community College Transfer Opportunities Program.

    ERIC Educational Resources Information Center

    J. Sargeant Reynolds Community Coll., Richmond, VA.

    An overview is provided of the activities and accomplishments of J. Sargeant Reynold Community College's (JSRCC) Urban Community Colleges Transfer Opportunities Program, which was designed to increase the number of minority students transferring to senior institutions. Introductory material highlights the means used to attain the program's…

  1. Aerobic Excercise and Research Opportunities to Benefit Impaired Children. (Project AEROBIC). Final Report.

    ERIC Educational Resources Information Center

    Idaho Univ., Moscow.

    The final report summarizes accomplishments of Project AEROBIC (Aerobic Exercise and Research Opportunities to Benefit Impaired Children), which provided a physical education exercise program for severely, profoundly, and multiply handicapped children aged 10-21. Activities are outlined for the 3 year period and include modification of exercise…

  2. Evaluation of the DC Opportunity Scholarship Program: First Year Report on Participation

    ERIC Educational Resources Information Center

    Wolf, Patrick; Eissa, Nada; Puma, Michael

    2005-01-01

    The District of Columbia School Choice Incentive Act of 2003 was passed by Congress in January 2004. The Act provided funds for District of Columbia Public Schools (DCPS) improvement activities and charter school facility acquisitions. Most notably, the statute established what is now called the DC Opportunity Scholarship Program?the first federal…

  3. Challenges and Opportunities of Information Technology in the 90s. Track VIII: Managing Distributed Computing Services.

    ERIC Educational Resources Information Center

    CAUSE, Boulder, CO.

    Six papers from the 1990 CAUSE Conference Track VIII: Managing Distributed Computing are presented. Authors discuss the challenges and opportunities involved in providing user managers with direct access to institutional databases to support their decision making and planning activities. Papers and their authors are as follows: "Rendering an…

  4. The Right to Learn: The Continuing Education Opportunities for Workers in Industries in Nigeria

    ERIC Educational Resources Information Center

    Osuji, Sydney Nwanakponna

    2005-01-01

    This paper examined the Industrial Training Fund, which was established to provide skill-oriented continuing education opportunities for industrial workers in Nigeria. Based on the critical examination of the provisions of the decree and the activities of the fund, suggestions are given towards the improvement of the policy and implementation.…

  5. A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.

    PubMed

    Ernest, Sylvain; Rosa, Frédéric M

    2015-09-01

    MYO7A is an unconventional myosin involved in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and balance. Mutations of MYO7A are responsible for abnormal shaping of hair bundles, resulting in human deafness and murine deafness/circling behavior. Myo7aa, expressed in SHCs of the inner ear and lateral line of zebrafish, causes circling behavior and abnormal hair cell function when deficient in mariner mutant. This work identifies a new hair cell-specific enhancer, highly conserved between species, located within Intron 2-3 of zebrafish myosin 7a (myo7aa) gene. This enhancer is contained within a 761-bp DNA fragment that encompasses a newly identified Exon of myo7aa and whose activity does not depend on orientation. Compensation of mariner mutation by expression of mCherry-Myo7aa fusion protein under the control of this 761-bp DNA fragment results in recovery of balance, normal hair bundle shape and restored hair cell function. Two smaller adjacent fragments (344-bp and 431-bp), extracted from the 761-bp fragment, both show hair cell-specific enhancing activity, with apparently reduced intensity and coverage. These data should help understand the role of Myo7aa in sensory hair cell differentiation and function. They provide tools to decipher how myo7aa gene is expressed and regulated in SHCs by allowing the identification of potential transcription factors involved in this process. The discovered enhancer could represent a new target for the identification of deafness-causing mutations affecting human MYO7A.

  6. Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome

    PubMed Central

    Urosevic, Jelena; Sauzeau, Vincent; Soto-Montenegro, María L.; Reig, Santiago; Desco, Manuel; Wright, Emma M. Burkitt; Cañamero, Marta; Mulero, Francisca; Ortega, Sagrario; Bustelo, Xosé R.; Barbacid, Mariano

    2011-01-01

    RASopathies are a class of developmental syndromes that result from congenital mutations in key elements of the RAS/RAF/MEK signaling pathway. A well-recognized RASopathy is the cardio-facio-cutaneous (CFC) syndrome characterized by a distinctive facial appearance, heart defects, and mental retardation. Clinically diagnosed CFC patients carry germ-line mutations in four different genes, B-RAF, MEK1, MEK2, and K-RAS. B-RAF is by far the most commonly mutated locus, displaying mutations that most often result in constitutive activation of the B-RAF kinase. Here, we describe a mouse model for CFC generated by germ-line expression of a B-RafLSLV600E allele. This targeted allele allows low levels of expression of B-RafV600E, a constitutively active B-Raf kinase first identified in human melanoma. B-Raf+/LSLV600E mice are viable and display several of the characteristic features observed in CFC patients, including reduced life span, small size, facial dysmorphism, cardiomegaly, and epileptic seizures. These mice also show up-regulation of specific catecholamines and cataracts, two features detected in a low percentage of CFC patients. In addition, B-Raf+/LSLV600E mice develop neuroendocrine tumors, a pathology not observed in CFC patients. These mice may provide a means of better understanding the pathophysiology of at least some of the clinical features present in CFC patients. Moreover, they may serve as a tool to evaluate the potential therapeutic efficacy of B-RAF inhibitors and establish the precise window at which they could be effective against this congenital syndrome. PMID:21383153

  7. Vehicle Technologies Program Funding Opportunities

    SciTech Connect

    2011-12-13

    The U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) provides funding opportunities for advanced vehicle technology projects that are aimed at removing technical and cost barriers. Much of the funding available to the Vehicle Technologies Program is distributed to private firms, educational institutions, nonprofit organizations, state and local governments, Native American organizations, and individuals, through competitive solicitations. DOE is strongly committed to partnerships to help ensure the eventual market acceptance of the technologies being developed. New solicitations are announced regularly.

  8. Special opportunities in helicopter aerodynamics

    NASA Technical Reports Server (NTRS)

    Mccroskey, W. J.

    1983-01-01

    Aerodynamic research relating to modern helicopters includes the study of three dimensional, unsteady, nonlinear flow fields. A selective review is made of some of the phenomenon that hamper the development of satisfactory engineering prediction techniques, but which provides a rich source of research opportunities: flow separations, compressibility effects, complex vortical wakes, and aerodynamic interference between components. Several examples of work in progress are given, including dynamic stall alleviation, the development of computational methods for transonic flow, rotor-wake predictions, and blade-vortex interactions.

  9. IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly.

    PubMed

    Pagnier, Adrien; Nicolet, Yvain; Fontecilla-Camps, Juan C

    2015-06-01

    Iron sulfur ([Fe-S]) clusters are essential prosthetic groups involved in fundamental cell processes such as gene expression regulation, electron transfer and Lewis acid base chemistry. Central components of their biogenesis are pyridoxal-5'-phosphate (PLP) dependent l-cysteine desulfurases, which provide the necessary S atoms for [Fe-S] cluster assembly. The archaeon Archaeoglobus fulgidus (Af) has two ORFs, which although annotated as l-cysteine desulfurases of the ISC type (IscS), lack the essential Lys residue (K199 in Af) that forms a Schiff base with PLP. We have previously determined the structure of an Af(IscU-D35A-IscS)2 complex heterologously expressed in Escherichia coli and found it to contain a [Fe2S2] cluster. In order to understand the origin of sulfide in that structure we have performed a series of functional tests using wild type and mutated forms of AfIscS. In addition, we have determined the crystal structure of an AfIscS-D199K mutant. From these studies we conclude that: i) AfIscS has no desulfurase activity; ii) in our in vitro [Fe2S2] cluster assembly experiments, sulfide ions are non-enzymatically generated by a mixture of iron, l-cysteine and PLP and iii) the physiological role of AfIscS may be to provide a cysteine ligand to the nascent cluster as observed in the [Fe2S2]-Af(IscU-D35A-IscS)2 complex. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases.

  10. Linking the SASSCAL WeatherNet and data management/rescue activities to provide consistent information for climate change assessments in Southern Africa

    NASA Astrophysics Data System (ADS)

    Helmschrot, J.; Kaspar, F.; Muche, G.; Hillmann, T.; Kanyanga, J.; Butale, M.; Nascimento, D.; Josenhans, K.; Falanga, E.; Neto, F. O. S.; Kruger, S.; Juergens, N.

    2014-12-01

    Many countries of Southern Africa face inadequate weather monitoring networks to provide reliable and consistent information for the development of efficient management strategies for sustainable water and land resources management, drought and flood risk analysis and forecasts as well as climate change impacts assessments. In addition, some existing networks are characterized by station data showing notable gaps in long-term observations. On the other hand, useful climate information is saved in historical documents and archives, but only barely explored up to now. Such documents are also available in archives of European meteorological services, partly also not yet in digital format. A main aim of the SASSCAL Initiative (Southern African Science Service Centre for Climate Change and Adaptive Land Management; www.sasscal.org) is to improve the availability of reliable meteorological baseline data along with a set of analytical methods to strengthen the research capacities in the SASSCAL region including Angola, Botswana, Namibia, South Africa and Zambia, and therewith to support and integrate information of existing national monitoring networks of the Southern African region. In close cooperation with the national weather authorities and various research institutions of the SASSCAL region, the above mentioned deficits are specifically addressed by i) extending the existing national monitoring networks through additional automatic weather stations and their integration in the SASSCAL WeatherNet which in near future hosts about 130 stations, ii) contributing to the development of Climate Data Management Systems (CDMS) at the national weather authorities in Angola, Botswana and Zambia and iii) the provision of additional time series of climate data based on the historic documents from various archives in all countries. The paper presents first results and shows how these efforts are linked to provide consistent climate information for Southern Africa in order to

  11. Expression analysis of genes encoding mitogen-activated protein kinases in maize provides a key link between abiotic stress signaling and plant reproduction.

    PubMed

    Sun, Wei; Chen, Hao; Wang, Juan; Sun, Hong Wei; Yang, Shu Ke; Sang, Ya Lin; Lu, Xing Bo; Xu, Xiao Hui

    2015-01-01

    Mitogen-activated protein kinases (MAPKs) play important roles in stress responses and development in plants. Maize (Zea mays), an important cereal crop, is a model plant species for molecular studies. In the last decade, several MAPKs have been identified in maize; however, their functions have not been studied extensively. Genome-wide identification and expression analysis of maize MAPK genes could provide valuable information for understanding their functions. In this study, 20 non-redundant maize MAPK genes (ZmMPKs) were identified via a genome-wide survey. Phylogenetic analysis of MAPKs from maize, rice (Oryza sativa), Arabidopsis (Arabidopsis thaliana), poplar (Populus trichocarpa), and tomato (Solanum lycopersicum) classified them into four major classes. ZmMPKs in the same class had similar domains, motifs, and genomic structures. Gene duplication investigations suggested that segmental duplications made a large contribution to the expansion of ZmMPKs. A number of cis-acting elements related to plant development and response to stress and hormones were identified in the promoter regions of ZmMPKs. Furthermore, transcript profile analysis in eight tissues and organs at various developmental stages demonstrated that most ZmMPKs were preferentially expressed in reproductive tissues and organs. The transcript abundance of most ZmMPKs changed significantly under salt, drought, cold, or abscisic acid (ABA) treatments, implying that they might participate in abiotic stress and ABA signaling. These expression analyses indicated that ZmMPKs might serve as linkers between abiotic stress signaling and plant reproduction. Our data will deepen our understanding of the complexity of the maize MAPK gene family and provide new clues to investigate their functions.

  12. Pollution prevention opportunity assessment approach, training, and technical assistance for DOE contractors

    SciTech Connect

    Pemberton, S.

    1997-03-01

    One of the tools used in a successful pollution prevention program is a pollution prevention opportunity assessment (PPOA). PPOAs can be used to identify the nature and amounts of waste and energy usage from processes and projects within a site`s operations, identify the opportunities that exist for pollution prevention and energy conservation, and then evaluate those opportunities for feasible implementation. The purpose of this project is to share the Kansas City Plant`s (KCP`s) PPOA methodology and experience with other DOE personnel and DOE contractors. This consisted of three major activities in FY96: (1) completing the PPOA training module specific to Environmental Restoration activities; (2) providing PPOA training and technical assistance to interested DOE personnel and DOE contractors, and (3) implementing and maintaining the DOE-wide PPOA database. This report documents the FY96 efforts, lessons learned, and future plans for all of the PPOA-related activities.

  13. Using the Concept of Zone of Proximal Development to Explore the Challenges of and Opportunities in Designing Discourse Activities Based on Practical Work

    ERIC Educational Resources Information Center

    Mestad, Idar; Kolstø, Stein Dankert

    2014-01-01

    This article reports a study in which two researchers collaborated with five teachers to facilitate discourse activities aimed to enhance students' learning from practical activities. The paper explores how certain teacher practices support or hinder students' learning. Four cases from the study were analyzed in depth using…

  14. Divergence in Enzymatic Activities in the Soybean GST Supergene Family Provides New Insight into the Evolutionary Dynamics of Whole-Genome Duplicates.

    PubMed

    Liu, Hai-Jing; Tang, Zhen-Xin; Han, Xue-Min; Yang, Zhi-Ling; Zhang, Fu-Min; Yang, Hai-Ling; Liu, Yan-Jing; Zeng, Qing-Yin

    2015-11-01

    Whole-genome duplication (WGD), or polyploidy, is a major force in plant genome evolution. A duplicate of all genes is present in the genome immediately following a WGD event. However, the evolutionary mechanisms responsible for the loss of, or retention and subsequent functional divergence of polyploidy-derived duplicates remain largely unknown. In this study we reconstructed the evolutionary history of the glutathione S-transferase (GST) gene family from the soybean genome, and identified 72 GST duplicated gene pairs formed by a recent Glycine-specific WGD event occurring approximately 13 Ma. We found that 72% of duplicated GST gene pairs experienced gene losses or pseudogenization, whereas 28% of GST gene pairs have been retained in the soybean genome. The GST pseudogenes were under relaxed selective constraints, whereas functional GSTs were subject to strong purifying selection. Plant GST genes play important roles in stress tolerance and detoxification metabolism. By examining the gene expression responses to abiotic stresses and enzymatic properties of the ancestral and current proteins, we found that polyploidy-derived GST duplicates show the divergence in enzymatic activities. Through site-directed mutagenesis of ancestral proteins, this study revealed that nonsynonymous substitutions of key amino acid sites play an important role in the divergence of enzymatic functions of polyploidy-derived GST duplicates. These findings provide new insights into the evolutionary and functional dynamics of polyploidy-derived duplicate genes.

  15. Aerobic Production and Utilization of Lactate Satisfy Increased Energy Demands Upon Neuronal Activation in Hippocampal Slices and Provide Neuroprotection Against Oxidative Stress

    PubMed Central

    Schurr, Avital; Gozal, Evelyne

    2012-01-01

    Ever since it was shown for the first time that lactate can support neuronal function in vitro as a sole oxidative energy substrate, investigators in the field of neuroenergetics have been debating the role, if any, of this glycolytic product in cerebral energy metabolism. Our experiments employed the rat hippocampal slice preparation with electrophysiological and biochemical methodologies. The data generated by these experiments (a) support the hypothesis that lactate, not pyruvate, is the end-product of cerebral aerobic glycolysis; (b) indicate that lactate plays a major and crucial role in affording neural tissue to respond adequately to glutamate excitation and to recover unscathed post-excitation; (c) suggest that neural tissue activation is accompanied by aerobic lactate and NADH production, the latter being produced when the former is converted to pyruvate by mitochondrial lactate dehydrogenase (mLDH); (d) imply that NADH can be utilized as an endogenous scavenger of reactive oxygen species (ROS) to provide neuroprotection against ROS-induced neuronal damage. PMID:22275901

  16. Model for end-stage liver disease exceptions committee activity in Argentina: does it provide justice and equity among adult patients waiting for a liver transplant?

    PubMed Central

    McCormack, Lucas; Gadano, Adrián; Lendoire, Javrer; Quiñonez, Emilio; Imventarza, Oscar; Andriani, Oscar; Toselli, Lorenzo; Gil, Octavio; Gondolesi, Gabriel; Bisigniano, Liliana; de Santibañes, Eduardo

    2010-01-01

    Background In 2005, the model of end-stage liver disease (MELD)-based allocation system was adopted to assess potential liver transplant (LT) recipients in Argentina. The aim of the present study was to revise the activity of the MELD Exception Experts Committee. Methods Between 2005 and 2009, 1623 patients were listed for LT. Regulation provides extra-MELD points for amyloidosis, hepatopulmonary syndrome (HPS) and T2 hepatocellular carcinoma (T2 HCC). Centres could also request priority for other situations. Using a prospective database, we identified patients in whom priority points were requested. Pathology reports of explanted livers were analysed for patients with T2 HCC. Results From 234 out of 1623 (14.4%) requests, the overall approval rate was 60.2% including: 2 amyloidosis, 6 HPS, 111 T2 HCC and 22 non-regulated situations. Of the 111 patients with T2 HCC, 6 died (5.4%), 8 had tumour progression (7.2%), 94 were transplanted (84.2%) and 3 are still waiting. An explants correlation showed that presumed diagnosis of T2HCC was incorrect in 20/94 (22%) and was correct in only 41/94 (43%) cases being T1 HCC in 9 and T3 HCC in 23. Conclusions MELD exceptions are frequently requested in Argentina. Unfortunately, most receiving priority points for T2 HCC benefited by medical error or imaging limitations. An intense review process is urgently needed to maintain equity and justice in the allocation system. PMID:20887320

  17. El Niño-Southern Oscillation influence on the dust storm activity in Australia: Can the past provide a key to the future?

    NASA Astrophysics Data System (ADS)

    Pudmenzky, C.; Stone, R.; Allan, R.; Butler, H.

    2011-12-01

    impacts on rural communities. All major continental scale dust storm events have occurred after periods of prolonged drought. The reconstruction of the ENSO history using longer-term meteorological data, historical records, and other proxy data that may otherwise have been available provides a far more lengthy and detailed global picture of past ENSO and other climate variability thereby allowing recent climate variability to be assessed from a long-term "multi-proxy" perspective. The resulting dataset can be used to better understand the range of past, present and future climate variability and the influence these have on the dust storm activity in Australia. In addition the information gained can provide an independent means of verifying climate model simulations. The scientific community is well aware that climate change is happening to some degree and Australia is already starting to experience the effects. In order to employ adaptation and mitigating measures it is necessary to understand the underlying mechanisms responsible for climate change.

  18. Physical activity, alcohol consumption, BMI and smoking status before and after prostate cancer diagnosis in the ProtecT trial: opportunities for lifestyle modification.

    PubMed

    Hackshaw-McGeagh, Lucy E; Penfold, Chris M; Walsh, Eleanor; Donovan, Jenny L; Hamdy, Freddie C; Neal, David E; Jeffreys, Mona; Martin, Richard M; Lane, J Athene

    2015-09-15

    Associations between certain lifestyle characteristics and prostate cancer risk have been reported, and continuation post-diagnosis can adversely affect prognosis. We explored whether men make spontaneous changes to their physical activity and alcohol intake, body mass index (BMI) and smoking status, following a diagnosis of localised prostate cancer. A detailed diet, health and lifestyle questionnaire was completed by 511 participants within the Prostate Testing for Cancer and Treatment (ProtecT) randomised controlled trial, both before and 9 months after a diagnosis of prostate cancer. Of 177 men who were insufficiently active before their diagnosis (median 0 activity units/week; IQR 0-9), 40.7% had increased their activity by a median of 22 U week(-1) (IQR 15-35) 9 months later, and there was weak evidence that men were more active after diagnosis than before (p = 0.07). Men categorised as "working" occupational social class and who were insufficiently active before diagnosis were 2.03 (95%, CI = 1.03-3.99, p = 0.04) times more likely to have increased their physical activity levels compared to men classified as "managerial or professional." Similarly, men who were insufficiently active pre-diagnosis and with T-stage 2 compared with T-stage 1 prostate cancer were 2.47 (95%, CI = 1.29-4.71, p = 0.006) times more likely to be sufficiently active post-diagnosis. Following diagnosis, there was an overall reduction in alcohol intake (p = 0.03) and the proportion of current smokers (p = 0.09), but no overall change in BMI. We conclude that some men spontaneously change certain lifestyle behaviours on receiving a diagnosis of prostate cancer. For many men, however, additional support through lifestyle interventions is probably required to facilitate and maintain these changes.

  19. Group Family Day Care Provider Handbook

    ERIC Educational Resources Information Center

    New York State Office of Children and Family Services, 2006

    2006-01-01

    Group family day care providers need to create high-quality programs where children have opportunities to grow, learn and thrive. Part of providing high-quality child care includes complying with the group family day care regulations from the New York State Office of Children and Family Services (OCFS). This Handbook will help day care providers:…

  20. Career Opportunities Instructional Guide. Student Materials.

    ERIC Educational Resources Information Center

    Hendrix, Mary W.

    These student materials are designed to accompany the Career Opportunities Instructional Guide. Page numbers are consistent with the numbering in that guide. Seventeen units are provided. The materials in Unit 1 concern aspects of locating information about occupations; Unit 2 provides an introduction to the 15 occupational clusters. Each of the…