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Sample records for activities recipient monitoring

  1. Efficacy and Safety of a Preemptive Antiviral Therapy Strategy Based on Combined Virological and Immunological Monitoring for Active Cytomegalovirus Infection in Allogeneic Stem Cell Transplant Recipients

    PubMed Central

    Navarro, David; Amat, Paula; de la Cámara, Rafael; López, Javier; Vázquez, Lourdes; Serrano, David; Nieto, José; Rovira, Monserrat; Piñana, José Luis; Giménez, Estela; Solano, Carlos

    2016-01-01

    Background. Preemptive antiviral therapy for active cytomegalovirus (CMV) infection in allogeneic stem cell transplant recipients (Allo-SCT) results in overtreatment and a high rate of recurrences. Monitoring of CMV-specific T-cell immunity may help to individualize treatments and minimize these problems. Methods. We conducted a prospective, multicenter, matched comparison-group study to evaluate the efficacy and safety of a novel strategy that consisted of interrupting anti-CMV therapy upon CMV DNAemia clearance and concurrent detection of phosphoprotein 65/immediate-early-1-specific interferon-γ-producing CD8+ T cells at levels of >1 cell/µL (within 30 days after the initiation of therapy). Immunological monitoring was performed on days +7, +14, +21, and +28 after treatment initiation. The primary endpoint was the cumulative incidence of recurrent DNAemia within 2 months after treatment cessation. Secondary endpoints were the length of antiviral treatment courses and the incidence of hematological toxicity. Results. Sixty-one patients were enrolled in the study group. Fifty-six patients were included in the matched-control group. Eleven patients (18%) fulfilled the criteria for antiviral treatment interruption. The cumulative incidence of recurrent CMV DNAemia was significantly lower (P = .02) in these patients than in patients in the comparative groups. Likewise, the length of antiviral treatment courses was significantly shorter in these patients than that in patients in the matched-control group (P = .003). No significant differences in the incidence of hematological toxicity was observed between the comparative groups. Conclusions. Our data support the clinical utility of combining immunological and virological monitoring for the management of CMV infection in a subset of Allo-SCT recipients. PMID:27419179

  2. 24 CFR 1000.508 - If the recipient monitoring identifies programmatic concerns, what happens?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 4 2012-04-01 2012-04-01 false If the recipient monitoring identifies programmatic concerns, what happens? 1000.508 Section 1000.508 Housing and Urban Development... Monitoring, Oversight and Accountability § 1000.508 If the recipient monitoring identifies...

  3. 24 CFR 1000.508 - If the recipient monitoring identifies programmatic concerns, what happens?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false If the recipient monitoring identifies programmatic concerns, what happens? 1000.508 Section 1000.508 Housing and Urban Development... Monitoring, Oversight and Accountability § 1000.508 If the recipient monitoring identifies...

  4. 24 CFR 1000.508 - If the recipient monitoring identifies programmatic concerns, what happens?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 4 2011-04-01 2011-04-01 false If the recipient monitoring identifies programmatic concerns, what happens? 1000.508 Section 1000.508 Housing and Urban Development... Monitoring, Oversight and Accountability § 1000.508 If the recipient monitoring identifies...

  5. 24 CFR 1000.508 - If the recipient monitoring identifies programmatic concerns, what happens?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 4 2013-04-01 2013-04-01 false If the recipient monitoring identifies programmatic concerns, what happens? 1000.508 Section 1000.508 Housing and Urban Development... Monitoring, Oversight and Accountability § 1000.508 If the recipient monitoring identifies...

  6. Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients

    PubMed Central

    Fadel, Fatina I.; Elghoroury, Eman A.; Elshamaa, Manal F.; Bazaraa, Hafez M.; Salah, Doaa M.; Kassem, Neemat M. A.; Ibrahim, Mona H.; El-Saaid, Gamila S.; Nasr, Soha A.; Koura, Hala M.

    2015-01-01

    Background and objectives: The role of CD4+CD25+ T regulatory cells (Tregs) in immune tolerance in experimental transplantation is very important but the clinical significance of circulating Tregs in the peripheral blood is undetermined. We evaluated the association between the frequency of T cell activation markers CD25 and CD71 and clinical parameters that may affect the level of these T cell markers. Methods: In 47peditric kidney transplant (KT) recipients and 20 healthy controls, the frequency of T cell activation markers, CD25 and CD71 was measured with flow cytometry after transplantation. Two clinical protocols of induction immunosuppression were used: (1) anti-thymocyte globulin (THYMO) group (n =29) and Basiliximab (BSX) group (n=10). Results: The percentage of circulating CD25 after KT was significantly lower than that in the controls. There is no significant difference between KT and the controls s regard to circulating CD71. The percentage of CD25 was significantly increased in children with acute rejection compared with those without acute rejection. Calcineurin inhibitors (CNIs) decreased the frequency of CD25 but mammalian target rapamycin (mTOR) inhibitor did not. The proportion of CD25 significantly decreased in THYMO group during the first year after transplantation. Conclusion: The frequency of circulating T cell activation marker CD25 in pediatric KT recipients is strongly affected by CNIs, and a high frequency of CD25 is associated with acute rejection during the early posttransplant period. The measurement of T cell activation markers, may become a useful immune monitoring tool after kidney transplantation. PMID:26508906

  7. RECIPIENT PRETRANSPLANT INOSINE MONOPHOSPHATE DEHYDROGENASE ACTIVITY IN NONMYELOABLATIVE HCT

    PubMed Central

    Bemer, Meagan J.; Risler, Linda J.; Phillips, Brian R.; Wang, Joanne; Storer, Barry E.; Sandmaier, Brenda M.; Duan, Haichuan; Raccor, Brianne S.; Boeckh, Michael J.; McCune, Jeannine S.

    2014-01-01

    Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis of guanosine nucleotides and catalyzes the oxidation of inosine 5’- monophosphate (IMP) to xanthosine 5’-monophosphate (XMP). We developed a highly sensitive liquid chromatography–mass spectrometry method to quantitate XMP concentrations in peripheral blood mononuclear cells (PMNC) isolated from the recipient pretransplant and used this method to determine IMPDH activity in 86 nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) patients. The incubation procedure and analytical method yielded acceptable within-sample and within-individual variability. Considerable between-individual variability was observed (12.2-fold). Low recipient pretransplant IMPDH activity was associated with increased day +28 donor T-cell chimerism, more acute graft-versus-host disease (GVHD), lower neutrophil nadirs, and more cytomegalovirus reactivation, but not with chronic GVHD, relapse, non-relapse mortality, or overall mortality. We conclude that quantitation of the recipient’s pretransplant IMPDH activity in PMNC lysate could provide a useful biomarker to evaluate a recipient’s sensitivity to MMF, but confirmatory studies are needed. Further trials should be conducted to confirm our findings and to optimize postgrafting immunosuppression in nonmyeloablative HCT recipients. PMID:24923537

  8. Physical activity and metabolic syndrome in liver transplant recipients.

    PubMed

    Kallwitz, Eric R; Loy, Veronica; Mettu, Praveen; Von Roenn, Natasha; Berkes, Jamie; Cotler, Scott J

    2013-10-01

    There is a high prevalence of metabolic syndrome in liver transplant recipients, a population that tends to be physically inactive. The aim of this study was to characterize physical activity and evaluate the relationship between physical activity and metabolic syndrome after liver transplantation. A cross-sectional analysis was performed in patients more than 3 months after transplantation. Metabolic syndrome was classified according to National Cholesterol Education Panel Adult Treatment Panel III guidelines. Physical activity, including duration, frequency, and metabolic equivalents of task (METs), was assessed. The study population consisted of 204 subjects, with 156 more than 1 year after transplantation. The median time after transplantation was 53.5 months (range = 3-299 months). The mean duration of exercise was 90 ± 142 minutes, and the mean MET score was 3.6 ± 1.5. Metabolic syndrome was observed in 58.8% of all subjects and in 63.5% of the subjects more than 1 year after transplantation. In a multivariate analysis involving all subjects, metabolic syndrome was associated with a time after transplantation greater than 1 year [odds ratio (OR) = 2.909, 95% confidence interval (CI) = 1.389-6.092] and older age (OR = 1.036, 95% CI = 1.001-1.072). A second analysis was performed for only patients more than 1 year after transplantation. In a multivariate analysis, metabolic syndrome was associated with lower exercise intensity (OR = 0.690, 95% CI = 0.536-0.887), older age (OR = 1.056, 95% CI = 1.014-1.101), and pretransplant diabetes (OR = 4.246, 95% CI = 1.300-13.864). In conclusion, metabolic syndrome is common after liver transplantation, and the rate is significantly higher in patients more than 1 year after transplantation. The observation that exercise intensity is inversely related to metabolic syndrome after transplantation is novel and suggests that physical activity might provide a means for reducing metabolic syndrome complications in liver

  9. Monitoring of Nonsteroidal Immunosuppressive Drugs in Patients With Lung Disease and Lung Transplant Recipients

    PubMed Central

    Meyer, Keith C; Nathanson, Ian; Angel, Luis; Bhorade, Sangeeta M; Chan, Kevin M; Culver, Daniel; Harrod, Christopher G; Hayney, Mary S; Highland, Kristen B; Limper, Andrew H; Patrick, Herbert; Strange, Charlie; Whelan, Timothy

    2012-01-01

    Objectives: Immunosuppressive pharmacologic agents prescribed to patients with diffuse interstitial and inflammatory lung disease and lung transplant recipients are associated with potential risks for adverse reactions. Strategies for minimizing such risks include administering these drugs according to established, safe protocols; monitoring to detect manifestations of toxicity; and patient education. Hence, an evidence-based guideline for physicians can improve safety and optimize the likelihood of a successful outcome. To maximize the likelihood that these agents will be used safely, the American College of Chest Physicians established a committee to examine the clinical evidence for the administration and monitoring of immunosuppressive drugs (with the exception of corticosteroids) to identify associated toxicities associated with each drug and appropriate protocols for monitoring these agents. Methods: Committee members developed and refined a series of questions about toxicities of immunosuppressives and current approaches to administration and monitoring. A systematic review was carried out by the American College of Chest Physicians. Committee members were supplied with this information and created this evidence-based guideline. Conclusions: It is hoped that these guidelines will improve patient safety when immunosuppressive drugs are given to lung transplant recipients and to patients with diffuse interstitial lung disease. PMID:23131960

  10. Trends of Criminal Activity and Substance Use in a Sample of Welfare Recipients

    ERIC Educational Resources Information Center

    Brown, Victoria L.; Montoya, Isaac D.; Dayton-Shotts, Cheryl A.; Carroll-Curtis, Tiffany L.; Riley, Micah A.

    2004-01-01

    The Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) of 1996 instituted a compulsory work mandate for welfare recipients. However, recipients who experience difficulties finding employment may increase their involvement in criminal activities and their frequency of substance use as a means to deal with changes precipitated…

  11. Monitoring of leukocyte cytomegalovirus DNA in bone marrow transplant recipients by nested PCR.

    PubMed Central

    Yuen, K Y; Lo, S K; Chiu, E K; Wong, S S; Lau, Y L; Liang, R; Chan, T K; Ng, M H

    1995-01-01

    A nested PCR assay for the detection of human cytomegalovirus (CMV) DNA was evaluated by weekly monitoring of blood samples taken from 101 bone marrow transplant (BMT) recipients. When peripheral blood leukocytes were used as the source of CMV DNA, even a modified assay with stringent temperature-cycling conditions was as sensitive as the standard assay. The sensitivity, specificity, and positive predictive value of two consecutively positive leukocytic PCR results with this modified assay in predicting CMV disease of 101 patients submitting 1,441 peripheral blood leukocyte samples were found to be 92.1, 63.5, and 60.3%, respectively. The positive predictive value of patients' seropositivity for CMV was 40%, while that of viremia was 72%. However, viremia followed CMV disease by a median of 1.5 days, while the first leukocytic positive PCR assay preceded disease by a median of 14 days. By use of the criteria of two consecutively positive PCR results instead of recipient CMV seropositivity for starting preemptive ganciclovir treatment, 38 of the 43 recipients with isolated single positive or negative assays (groups I and II) would be spared unnecessary ganciclovir treatment. Moreover, two other findings support the use of antiviral prophylaxis before engraftment in high-risk cases and subsequent preemptive treatment of patients with two consecutively positive PCR assays. First, for 7.9% of 76 patients with positive assays (groups II and III), the first positive PCR assay occurred before engraftment, which implied the presence of viral DNA in the blood (DNAemia) soon after transplantation.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8567878

  12. MCO Monitoring activity description

    SciTech Connect

    SEXTON, R.A.

    1998-11-09

    Spent Nuclear Fuel remaining from Hanford's N-Reactor operations in the 1970s has been stored under water in the K-Reactor Basins. This fuel will be repackaged, dried and stored in a new facility in the 200E Area. The safety basis for this process of retrieval, drying, and interim storage of the spent fuel has been established. The monitoring of MCOS in dry storage is a currently identified issue in the SNF Project. This plan outlines the key elements of the proposed monitoring activity. Other fuel stored in the K-Reactor Basins, including SPR fuel, will have other monitoring considerations and is not addressed by this activity description.

  13. BK polyomavirus in kidney transplant recipients: screening, monitoring and clinical management.

    PubMed

    Varella, Rafael Brandão; Almeida, Jorge Reis; Lopes, Patrícia de Fátima; Matos, Jorge Paulo Strogoff de; Menezes, Paulo; Lugon, Jocemir Ronaldo

    2014-01-01

    BK polyomavirus (BKPyV) is a causal agent of nephropathy, ureteral stenosis and hemorrhagic cystitis in kidney transplant recipients, and is considered an important emerging disease in transplantation. Regular screening for BKPyV reactivation mainly during the first 2 years posttransplant, with subsequent pre-emptive reduction of immunosuppression is considered the best option to avoid disease progression, since successful clearance or reduction of viremia is achieved in the vast majority of patients within 6 months. The use of drugs with antiviral properties for patients with persistent viremia has been attempted despite unclear benefits. Clinical manifestations of BKPyV nephropathy, current strategies for diagnosis and monitoring of BKPyV infection, management of immunosuppressive regimen after detection of BKPyV reactivation and the use of antiviral drugs are discussed in this review.

  14. MicroCRP: a highly sensitive CRP method applied in the monitoring of renal allograft recipients.

    PubMed

    Wergeland, R; Oyen, O; Bentdal, O; Stokke, O

    1999-10-01

    A new ultrasensitive fluoroimmunometric assay for C-reactive protein (CRP), called MicroCRP assay, has a lower detection limit of 0.05 mg/l, and a CV of 7.6% at concentration 0.25 mg/l. The microCRP levels in healthy adults show a skewed distribution, median 0.90 mg/l and mean 1.4 mg/l, with 2.5th and 97.5th percentiles of 0.17 and 4.7 mg/l, respectively, and no gender-related or age differences. Serial microCRP was applied in the monitoring of 37 renal allograft recipients. The operative trauma gave rise to an initial CRP peak, usually on day 2 after transplantation, with a return to preoperative value 1 week after surgery. There were significant CRP elevations (>25%) in all cases of rejections, indicating 100% sensitivity. The microCRP values started to increase about 3 days (range -1 to 9 days) before the rise in creatinine. The microCRP peak tended to be higher in rejection episodes with a vascular component, compared with episodes of cellular rejection (p=0.05). A rise in microCRP at days 7-12 after transplantation seems to predict the risk of rejections later on, and probably reflects the primary immune response to the graft. Recipients without this primary CRP response (only 6 of 37 patients) subsequently had uncomplicated courses. Tracking of values below the traditional lower limit is essential in order to recognize the different CRP peaks. Serial monitoring of microCRP is well suited for clinical use and provides clinical information previously unattainable with other assay systems.

  15. Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function.

    PubMed

    Han, Seung Seok; Yang, Seung Hee; Kim, Min Chang; Cho, Joo-Youn; Min, Sang-Il; Lee, Jung Pyo; Kim, Dong Ki; Ha, Jongwon; Kim, Yon Su

    2016-01-01

    Although monitoring the intracellular concentration of immunosuppressive agents may be a promising approach to individualizing the therapy after organ transplantation, additional studies on this issue are needed prior to its clinical approval. We investigated the relationship between intracellular and whole blood concentrations of tacrolimus (IC-TAC and WB-TAC, respectively), the factors affecting this relationship, and the risk of rejection based upon IC-TAC in stable kidney recipients. Both IC-TAC and WB-TAC were measured simultaneously in 213 kidney recipients with stable graft function using LC-MS/MS. The tacrolimus ratio was defined as IC-TAC per WB-TAC. The genetic polymorphism of ABCB1 gene and flow cytometric analyses were conducted to probe the correlation between tacrolimus concentrations and the immunoreactivity status as a potential risk of rejection, respectively. The correlation between IC-TAC and WB-TAC was relatively linear (r = 0.67; P<0.001). The factors affecting the tacrolimus ratio were sex, hematocrit, and the transplant duration, as follows: a high tacrolimus ratio was noted in female patients, patients with a low hematocrit, and patients with a short transplant period. However, the tacrolimus ratio did not reflect the prior clinical outcomes (e.g., rejection) or the genetic polymorphism of ABCB1. After stimulation with phorbol-12-myristate 13-acetate and ionomycin, the proportion of T cells producing interferon-gamma or interleukin-2 was higher in the low-IC-TAC group than in the high-IC-TAC group. Further studies are required to evaluate the value of the intracellular tacrolimus concentrations in several clinical settings, such as rejection, infection, and drug toxicity.

  16. Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature.

    PubMed

    Ng, Joan C Y; Leung, Marianna; Wright, Alissa J; Ensom, Mary H H

    2017-02-28

    Leflunomide is an immunosuppressive drug with in vitro and initial observational evidence of antiviral activity against BK virus (BKV), a pathogen that causes opportunistic infection upon reactivation in renal transplant recipients. Leflunomide is considered an ancillary option to immunosuppression reduction in the management of BKV reactivation. Plasma or blood concentrations of teriflunomide, the active metabolite of leflunomide, are commonly monitored because of high leflunomide doses being used, known inter-individual variability in pharmacokinetics, and hepatotoxicity risk. However, the utility of clinical pharmacokinetic monitoring for leflunomide is as yet unclear. A literature search of MEDLINE (1946-December 2016), EMBASE (1974-December 2016), the CENTRAL database, and Google Scholar was performed to identify relevant English-language articles. Further articles were identified from references in relevant literature. A previously published 9-step decision-making algorithm was used to assess the available literature and determine the utility of clinical pharmacokinetic monitoring for leflunomide. Teriflunomide is readily measurable in the plasma or blood, but a clear relationship between concentration and efficacy or toxicity is lacking, and its therapeutic range is not well-established. Efficacy and toxicity endpoints such as renal function and BKV clearance can be readily assessed without measuring teriflunomide concentrations. Pharmacokinetic parameters are affected by genetic polymorphisms in cytochrome P450 CYP2C19 and ABCG2 genes. Therefore, routine clinical pharmacokinetic monitoring of leflunomide cannot be recommended based on current available evidence. However, it may provide clinical benefit in difficult situations when patients demonstrate a lack of therapeutic response or exhibit signs of drug toxicity.

  17. Recipient pretransplant inosine monophosphate dehydrogenase activity in nonmyeloablative hematopoietic cell transplantation.

    PubMed

    Bemer, Meagan J; Risler, Linda J; Phillips, Brian R; Wang, Joanne; Storer, Barry E; Sandmaier, Brenda M; Duan, Haichuan; Raccor, Brianne S; Boeckh, Michael J; McCune, Jeannine S

    2014-10-01

    Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis of guanosine nucleotides and catalyzes the oxidation of inosine 5'-monophosphate to xanthosine 5'-monophosphate (XMP). We developed a highly sensitive liquid chromatography-mass spectrometry method to quantitate XMP concentrations in peripheral blood mononuclear cells (PMNCs) isolated from the recipient pretransplant and used this method to determine IMPDH activity in 86 nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) patients. The incubation procedure and analytical method yielded acceptable within-sample and within-individual variability. Considerable between-individual variability was observed (12.2-fold). Low recipient pretransplant IMPDH activity was associated with increased day +28 donor T cell chimerism, more acute graft-versus-host disease (GVHD), lower neutrophil nadirs, and more cytomegalovirus reactivation but not with chronic GVHD, relapse, nonrelapse mortality, or overall mortality. We conclude that quantitation of the recipient's pretransplant IMPDH activity in PMNC lysate could provide a useful biomarker to evaluate a recipient's sensitivity to MMF. Further trials should be conducted to confirm our findings and to optimize postgrafting immunosuppression in nonmyeloablative HCT recipients.

  18. Limited sampling strategy for cyclosporine (Neoral) area under the curve monitoring in pediatric kidney transplant recipients.

    PubMed

    Strong, Dawn K; Lai, Amanda; Primmett, Dennis; White, Colin T; Lirenman, David S; Carter, James E; Hurley, R Morrison; Virji, Mumtaz; Ensom, Mary H H

    2005-10-01

    Cyclosporine (CSA; Neoral) is one of the most common immunosuppressants used in pediatric renal transplantation. Research in adult renal transplant recipients has shown that 2-h post-dose concentration (C2) monitoring and limited sampling strategies (LSSs) are better at predicting drug exposure and outcome than trough concentrations (C0). While C0 monitoring is the usual practice in pediatric renal transplant patients, area under the curve (AUC) monitoring has been shown to be superior in terms of predictive ability and outcomes. However, AUC monitoring is impractical and inconvenient in a clinic setting because it involves many blood samples. An LSS provides a reliable alternative. The purpose of this study was to prospectively define an LSS (AUC(0-12)) for CSA monitoring and to test its predictive performance. As well, an LSS (AUC(0-4)) for CSA was developed and its predictive performance tested. Blood samples for CSA concentrations were collected in 29 stable pediatric renal transplant patients prior to (t = 0) and at 0.5, 1, 2, 4, 6, and 8 h following a steady-state morning CSA dose. AUC was calculated by the trapezoidal method; LSSs for AUC(0-12) and AUC(0-4) were determined using multiple regression analysis in 14 patients; and the LSSs' predictive performance was tested in 15 additional patients. Both LSSs require two blood samples. For the LSS (AUC(0-12)), blood samples are required immediately before the dose and 2 h post-dose: AUC(0-12) = 12.45 C0 + 2.17 C2 + 723.16 (r2 = 0.909). For the LSS (AUC(0-4)), blood samples are required at one and 2 h post-dose, AUC(0-4) = 1.17 C1 + 1.85 C2 - 41.00 (r2 = 0.971). The LSSs demonstrated low bias and high precision for both AUC(0-12) and AUC(0-4). Our two-concentration LSSs are accurate and precise predictors that are more clinically useful for our patient population than other LSSs that have been developed for pediatric renal transplant patients. Our study template provides a guide for other centers to develop

  19. Small Active Radiation Monitor

    NASA Technical Reports Server (NTRS)

    Badhwar, Gautam D.

    2004-01-01

    A device, named small active radiation monitor, allows on-orbit evaluations during periods of increased radiation, after extravehicular activities, or at predesignated times for crews on such long-duration space missions as on the International Space Station. It also permits direct evaluation of biological doses, a task now performed using a combination of measurements and potentially inaccurate simulations. Indeed the new monitor can measure a full array of radiation levels, from soft x-rays to hard galactic cosmic-ray particles. With refinement, it will benefit commercial (nuclear power-plant workers, airline pilots, medical technicians, physicians/dentists, and others) and military personnel as well as the astronauts for whom thermoluminescent dosimeters are inadequate. Civilian and military personnel have long since graduated from film badges to thermoluminescent dosimeters. Once used, most dosimeters must be returned to a central facility for processing, a step that can take days or even weeks. While this suffices for radiation workers for whom exposure levels are typically very low and of brief duration, it does not work for astronauts. Even in emergencies and using express mail, the results can often be delayed by as much as 24 hours. Electronic dosimeters, which are the size of electronic oral thermometers, and tattlers, small electronic dosimeters that sound an alarm when the dose/dose rate exceeds preset values, are also used but suffer disadvantages similar to those of thermoluminescent dosimeters. None of these devices fully answers the need of rapid monitoring during the space missions. Instead, radiation is monitored by passive detectors, which are read out after the missions. Unfortunately, these detectors measure only the absorbed dose and not the biologically relevant dose equivalent. The new monitor provides a real-time readout, a time history of radiation exposures (both absorbed dose and biologically relevant dose equivalent), and a count of the

  20. Impacting Mediators of Change for Physical Activity among Elderly Food Stamp Recipients

    ERIC Educational Resources Information Center

    Dye, Cheryl J.; Williams, Joel E.; Kemper, Karen A.; McGuire, Francis A.; Aybar-Damali, Begum

    2012-01-01

    A multidisciplinary team developed and pilot-tested a curriculum, delivered by trained lay educators, to increase self-efficacy for physical activity among elderly food stamp recipients. Curriculum development was guided by a comprehensive literature review. Process evaluation was used to revise the curriculum and to assess lay educator training…

  1. Monitoring international nuclear activity

    SciTech Connect

    Firestone, R.B.

    2006-05-19

    The LBNL Table of Isotopes website provides primary nuclearinformation to>150,000 different users annually. We have developedthe covert technology to identify users by IP address and country todetermine the kinds of nuclear information they are retrieving. Wepropose to develop pattern recognition software to provide an earlywarning system to identify Unusual nuclear activity by country or regionSpecific nuclear/radioactive material interests We have monitored nuclearinformation for over two years and provide this information to the FBIand LLNL. Intelligence is gleaned from the website log files. Thisproposal would expand our reporting capabilities.

  2. Incidence and diagnosis of active toxoplasma infection among liver transplant recipients in Western Turkey.

    PubMed

    Caner, Ayşe; Döşkaya, Mert; Karasu, Zeki; Değirmenci, Aysu; Guy, Edward; Kiliç, Murat; Zeytunlu, Murat; Francis, Janet; Bozoklar, Ata; Gürüz, Yüksel

    2008-10-01

    Toxoplasmosis is a serious and potentially life-threatening disease in liver transplant recipients while they are immunosuppressed. We report the clinical and laboratory findings related to active toxoplasma infection associated with 40 immunosuppressed liver transplant procedures that took place over a 12-month period at a major transplant unit in Izmir, Turkey. Twenty-seven (67.5%) of the 40 transplant recipients were found to be seropositive for toxoplasma infection and therefore at risk of reactivated infection. From the serological status of the donors, which was ascertained in 38 of 40 cases, we identified 3 (7.9%) of 38 transplants to be from a seropositive donor to a seronegative recipient. In 10 (26.3%) of 38 transplants, both the donor and recipient were seronegative, and this excluded toxoplasma as a risk. A comparison of real-time polymerase chain reaction (PCR) and nested PCR was undertaken in combination with a range of serological assays (the Sabin-Feldman dye test, enzyme immunoassay immunoglobulin M, and immunosorbent agglutination assay immunoglobulin M). Ethylene diamine tetraacetic acid blood samples from 3 of the 30 recipients at risk from toxoplasma were found positive by PCR, but only 1 of these was found positive in both assays. Among the 3 PCR-positive patients, immunoglobulin M and immunoglobulin G antibody levels increased in only 1 patient. Correlations between symptoms, laboratory findings, and clinical management (use of anti-toxoplasma therapy) are presented. Our findings suggest that toxoplasma presents a significant risk to our liver transplant population and that PCR is a helpful addition in identifying active infections and hence in informing clinical management decisions.

  3. PHARMACOKINETIC AND PHARMACODYNAMIC ANALYSIS OF INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) ACTIVITY IN MMF-TREATED HCT RECIPIENTS

    PubMed Central

    Li, Hong; Mager, Donald E.; Sandmaier, Brenda M.; Storer, Barry E.; Boeckh, Michael J.; Bemer, Meagan J.; Phillips, Brian R.; Risler, Linda J.; McCune, Jeannine S.

    2014-01-01

    A novel approach to personalizing postgrafting immunosuppression in hematopoietic cell transplant (HCT) recipients is evaluating inosine monophosphate dehydrogenase (IMPDH) activity as a drug-specific biomarker of mycophenolic acid (MPA)-induced immunosuppression. This prospective study evaluated total MPA, unbound MPA, and total MPA glucuronide plasma concentrations and IMPDH activity in peripheral blood mononuclear cells (PMNC) at five time points after the morning dose of oral mycophenolate mofetil (MMF) on day +21 in 56 nonmyeloablative HCT recipients. Substantial interpatient variability in the pharmacokinetics and pharmacodynamics was observed and accurately characterized by the population pharmacokinetic/dynamic model. IMPDH activity decreased with increasing MPA plasma concentration, with maximum inhibition coinciding with maximum MPA concentration in most patients. The overall relationship between MPA concentration and IMPDH activity was described by a direct inhibitory Emax model with an IC50 = 3.23 mg/L total MPA and 57.3 ng/mL unbound MPA. The day +21 IMPDH area under the effect curve (AUEC) was associated with cytomegalovirus reactivation, non-relapse mortality, and overall mortality. In conclusion, a pharmacokinetic/dynamic model was developed that relates plasma MPA concentrations with PMNC IMPDH activity after an MMF dose in HCT recipients. Future studies should validate this model and confirm that day +21 IMPDH AUEC is a predictive biomarker. PMID:24727337

  4. Plasma glutathione peroxidase activity in kidney recipients with and without adverse outcome.

    PubMed

    Eftekhar, Ebrahim; Hajirahimkhan, Athie; Taghizadeh Afshari, Ali; Nourooz-Zadeh, Jaffar

    2012-01-01

    Kidney function is routinely monitored utilizing classic biochemical parameters including serum or plasma creatinine (Cr), and blood urea nitrogen (BUN) concentrations. This study demonstrates that the simultaneous assessment of plasma glutathione peroxidase (pGPx) and Cr levels provides a better strategy for the immediate follow-up of kidney function in organ recipients. Kidney recipients (Krs; n = 22) were recruited. Blood sampling schedule commenced at day 1 (pre-transplantation) and post-transplantation days (i.e., everyday from 1 until day 14, and thereafter on days 21, 28, 35, 42, 49, and 56). pGPx was measured spectrophotometrically. Candidates for transplantation exhibited lower pGPx than control subjects (42 ± 24 vs. 143 ± 31 U/L; p < 0.005). In Krs with a stable post-transplant outcome, pGPx increased to a maximum at day 28 (214 ± 61 U/L). In a Kr diagnosed with acute tubulonecrosis, pGPx provided a better predictive value (threefold increase) than Cr. In a Kr diagnosed with acute rejection, the increment in Cr values was found to be more pronounced than in pGPx values. The pGPx test is simple, inexpensive and automatable, and should be a valuable diagnostic tool of kidney function in organ recipients with and without troublesome outcome for the follow-up during hospitalization period.

  5. [The antioxidant activity of components of blood serum of donors and recipients before liver transplantation].

    PubMed

    Sazhina, N N; Titov, V N; Popov, I N; Solonin, S A; Godkov, M A

    2014-08-01

    The antioxidant activity is implemented in human blood serum by ascorbic acid, uric acid, amino acids, glucose, mono unsaturated fatty acids (in the first instance Ω-9 oleic acid), essential polyenoic fatty acids, thiol groups of albumins and proteins, tripeptide and pigment of bilirubin. The antioxidant activity of blood serum of donors and recipients before liver transplantation was determined The input of particular biochemical analytes into liver transplantation was determined too. The antioxidant parameters were detected using technique of termo-induced chemiluminescence under application of set of corresponding reagents. The analysis of antioxidant activity of blood serum in donors and recipients with hepatic pathology revealed in vivo a significant disorder in the syndrome of compensatory anti-inflammatory defense. Under hepatic pathology, absence of endogenous ascorbic acid, deficiency of exogenous ascorbic acid and disorder of antioxidant activity the uric acid and bilirubin become the major hydrophilic acceptors of active forms of oxygen and inhibitors of oxidative processes in vivo. In patients with physiological level of bilirubin the uric acid provides 40%-80% of antioxidant activity. In case of high hyperbilirubinemia in recipients only 9.6%. It is possible to consider hyperiricosuria under aphysiological processes as a nonspecific test of activation of biological reaction of inflammation, syndrome of compensatory anti-inflammatory defense and test of disorder of biological function of endoecology. To activate the syndrome of compensatory anti-inflammatory defense it is very important to decrease both hyperiricosuria and compensatory function of uric acid as an acceptor of active forms of oxygen by force of prolonged intake of optimal amount of ascorbic acid.

  6. Potential of predominant activated sludge bacteria as recipients in conjugative plasmid transfer.

    PubMed

    Inoue, Daisuke; Sei, Kazunari; Soda, Satoshi; Ike, Michihiko; Fujita, Masanori

    2005-12-01

    We investigated the possibility of conjugative plasmid transfer to the predominant bacteria in activated sludge and the factors influencing the transfer frequency in the activated sludge process. We performed conjugative transfers of a self-transmissible, broad-host-range plasmid RP4 from Escherichia coli C600 to activated sludge bacteria by broth mating. Most of the activated sludge bacteria tested could acquire plasmid RP4, although the transfer frequencies varied from 8.8 x 10(-7) to 1.3 x 10(-2) transconjugants per recipient. The transfer frequencies in several strains were similar to, or higher than, that in intraspecific transfer to E. coli HB101. Matings under various environmental conditions showed that factors relevant to physiological activity, such as temperature and nutrient conditions, seemed to affect the transfer frequency. In addition, conjugative transfer was detected even in filtered raw and treated wastewaters. Thus, the predominant activated sludge bacteria seem to have sufficient potential as recipients in conjugative plasmid transfer under the conditions likely to occur in the activated sludge process. Transfer frequency was reduced by agitation in the presence of suspended solid. This may suggest that conjugative plasmid transfer is physically inhibited in aeration tanks.

  7. Immune activation- and regulation-related patterns in stable hand transplant recipients.

    PubMed

    Kamińska, Dorota; Kościelska-Kasprzak, Katarzyna; Krajewska, Magdalena; Chełmoński, Adam; Jabłecki, Jerzy; Żabińska, Marcelina; Myszka, Marta; Banasik, Mirosław; Boratyńska, Maria; Gomółkiewicz, Agnieszka; Dzięgiel, Piotr; Klinger, Marian

    2017-02-01

    We assessed cell subsets and expression of a set of genes related to the T-cell populations in peripheral blood mononuclear cells to elucidate whether immune status of stable hand transplant recipients (HTx) differs from stable kidney transplant recipients (KTx). The study was conducted on five HTx 4.8 ± 1.7 years after transplantation and 30 stable KTx 7.9 ± 2.4 years after transplantation as well as 18 healthy volunteers. The research involved PBMC gene expression analysis of CD4, CD8, CTLA4, GZMB, FOXP3, IL10, IL4, ILR2A, NOTCH, PDCD1, PRF1, TGF-B, and TNF-A genes on a custom-designed low-density array (TaqMan) as well as flow cytometry assessment of lymphocyte subpopulations. HTx presented significantly increased expression of immunomodulatory genes (TNF, IL10, GITR, and PDCD1) compared to KTx and controls. HTx revealed a proinflammatory molecular pattern with higher expression of NOTCH and CD8 compared to KTx and controls. KTx showed a reduced level of regulatory T cells compared to controls and HTx. Both HTx and KTx presented an increased number of CD8(+) and CD8(+) CD28(-) T cells compared to controls. Stable hand transplant recipients exhibit persistent immune activation with rejection-related gene expression pattern counterbalanced by secondary induction of regulatory mechanisms.

  8. Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipients.

    PubMed

    Borgogna, Cinzia; Lanfredini, Simone; Peretti, Alberto; De Andrea, Marco; Zavattaro, Elisa; Colombo, Enrico; Quaglia, Marco; Boldorini, Renzo; Miglio, Umberto; Doorbar, John; Bavinck, Jan N Bouwes; Quint, Koen D; de Koning, Maurits N C; Landolfo, Santo; Gariglio, Marisa

    2014-08-01

    The aim of this study was to determine whether detection of β-HPV gene products, as defined in epidermodysplasia verruciformis skin cancer, could also be observed in lesions from kidney transplant recipients alongside the viral DNA. A total of 111 samples, corresponding to 79 skin lesions abscised from 17 kidney transplant recipients, have been analyzed. The initial PCR analysis demonstrated that β-HPV-DNA was highly present in our tumor series (85%). Using a combination of antibodies raised against the E4 and L1 proteins of the β-genotypes, we were able to visualize productive infection in 4 out of 19 actinic keratoses, and in the pathological borders of 1 out of 14 squamous cell carcinomas and 1 out of 31 basal cell carcinomas. Increased expression of the cellular proliferation marker minichromosome maintenance protein 7 (MCM7), that extended into the upper epithelial layers, was a common feature of all the E4-positive areas, indicating that cells were driven into the cell cycle in areas of productive viral infections. Although the present study does not directly demonstrate a causal role of these viruses, the detection of E4 and L1 positivity in actinic keratosis and the adjacent pathological epithelium of skin cancer, clearly shows that β-HPV are actively replicating in the intraepidermal precursor lesions of kidney transplant recipients and can therefore cooperate with other carcinogenic agents, such as UVB, favoring skin cancer promotion.

  9. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients.

    PubMed

    Chocair, P R; Duley, J A; Simmonds, H A; Cameron, J S

    1992-05-01

    The immunosuppressive efficacy of azathioprine is related to its rapid metabolism in vivo to 6-mercaptopurine (6MP), with subsequent conversion to thioguanine nucleotides by an anabolic route involving hypoxanthine-guanine phosphoribosyltransferase. Two alternative catabolic routes exist: oxidation to 6-thiouric acid via xanthine oxidase and methylation to 6-methylmercaptopurine via the enzyme thiopurine methyltransferase (TPMT). Catabolism via either route would restrict formation of the active metabolites. We analyzed TPMT activity in erythrocyte lysates of 25 controls, 25 uremic patients on dialysis, and 68 transplanted patients. Median activity was lower in controls (31.0 pmol/hr/mg Hb, range 16.2-43.0) and transplanted patients receiving only cyclosporine and prednisolone (31.7 pmol/hr/mg Hb, range 12.7-43.5) than in the azathioprine treated group, (36.1 pmol/hr/mg Hb, range 16.1-71.3), or the uremic group on dialysis, (35.5 pmol/hr/mg Hb, range 18.6-62.6) suggesting that both azathioprine and uremia induce the enzyme, but CsA does not. Only 3 patients demonstrated total intolerance to azathioprine, 2 of whom had very low TPMT activity (zero and 12.7 pmol/hr/mg Hb). The intolerance of the third patient, despite high TPMT activity, was attributed to concomitant cotrimoxazole therapy. Patients with intermediate activity (15-26 pmol/hr/mg Hb) could tolerate azathioprine well. Of 29 cadaver recipients given only azathioprine plus prednisolone, 24 with a better clinical outcome had a significantly lower activity (33.1 pmol/hr/mg Hb, range 16.1-46.1) than 5 with reduced allograft function (42.5 pmol/hr/mg Hb, range 33.8-51.5). TPMT activity in these 24 patients was also significantly lower than the general group of azathioprine-treated recipients. This inverse association between TPMT activity and allograft function was again found among 30 patients receiving triple therapy (azathioprine, CsA, prednisolone). Self-selection of the best recipients for azathioprine

  10. The influence of prophylactic immunosuppressive regimens on natural killer and lymphokine-activated killer cells in renal transplant recipients.

    PubMed

    Alamartine, E; Sabido, O; Berthoux, F C

    1990-12-01

    We investigated natural-killer cells in 81 renal transplant recipients (RTR) in order to define what kind of in vivo prophylactic immunosuppression could be responsible of the impairment of these NK cells. Cell-surface phenotyping was performed by direct immunofluorescence with Leu7 (CD57), Leu11 (CD16), and Leu19 (CD56) antibodies, in one- and two-color stainings. Functional properties were analyzed with freshly isolated nonadherent mononuclear cells (NK activity) and after in vitro activation with r-IL-2 (LAK activity), in cytotoxicity assays using K562 and Daudi tumor lines as specific targets. A flow cytometry technique using carboxy-Fluorodiacetate was applied to monitor the cytotoxicity of NK cells. Our data emphasize the already known deficiency of NK cells: both NK subsets (CD16+ and/or CD56+) and NK activity were decreased in RTR. Moreover, we demonstrated that the in vitro IL-2-induced LAK cytotoxicity was also diminished in RTR. NK cells and functions were normal in RTR treated with cyclosporine only, decreased in RTR treated with both cyclosporine and azathioprine, and at the lowest level in RTR treated with azathioprine without cyclosporine. A multivariate statistical analysis found a negative linear regression between the doses of azathioprine and the number of functions of NK cells, confirming that azathioprine was responsible for the deficiency of NK cells in our RTR.

  11. Perceived Barriers to and Facilitators of Physical Activity in Recipients of Solid Organ Transplantation, a Qualitative Study

    PubMed Central

    van de Zande, Saskia C.; Dekker, Rienk; Verschuuren, Erik A. M.; Dijkstra, Pieter U.; van der Schans, Cees P.

    2016-01-01

    Background Sufficient physical activity is important for solid organ transplant recipients (heart, lung, liver, kidney). However, recipients do not meet the recommended amount or required type of physical activity. The perceived barriers to and facilitators of physical activity in this population are largely unknown. Methods Semi-structured in depth interviews were conducted with solid organ transplant recipients in order to explore experienced barriers and facilitators. Qualitative methodology with thematic line-by-line analysis was used for analysis, and derived themes were classified into personal and environmental factors. Results The most important indicated barriers were physical limitations, insufficient energy level, fear, and comorbidities. The most frequently mentioned facilitators included motivation, coping, consequences of (in)activity, routine/habit, goals/goal priority, and responsibility for the transplanted organ. Neutral factors acting as a barrier or facilitator were self-efficacy and expertise of personnel. A comparison of barriers and facilitators between transplant recipient groups yielded no overt differences. Conclusion Several personal and environmental factors were indicated that should be considered in intervention development to increase physical activity behavior in solid organ transplant recipients. PMID:27622291

  12. Monitoring active volcanoes

    USGS Publications Warehouse

    Tilling, Robert I.

    1987-01-01

    One of the most spectacular, awesomely beautiful, and at times destructive displays of natural energy is an erupting volcano, belching fume and ash thousands of meters into the atmosphere and pouring out red-hot molten lava in fountains and streams. Countless eruptions in the geologic past have produced volcanic rocks that form much of the Earth's present surface. The gradual disintegration and weathering of these rocks have yielded some of the richest farmlands in the world, and these fertile soils play a significant role in sustaining our large and growing population. Were it not for volcanic activity, the Hawaiian Islands with their sugar cane and pineapple fields and magnificent landscapes and seascapes would not exist to support their residents and to charm their visitors. Yet, the actual eruptive processes are catastrophic and can claim life and property.

  13. Gene expression profiling for monitoring graft rejection in heart transplant recipients.

    PubMed

    Crespo-Leiro, M G; Paniagua-Martín, M J; Hermida-Prieto, M; Castro-Beiras, A

    2009-01-01

    Heart transplantation is a life-prolonging therapy for many patients with stage D heart failure and other forms of advanced heart disease. However, graft rejection and/or immunosuppression-related side effects are major causes of morbidity and death among heart transplant patients. Graft rejection monitoring remains a challenge. It would be desirable to be able to detect rejection early enough and specifically enough to prevent allograft dysfunction without unnecessary overimmunosuppression. Hitherto, the main technique employed in monitoring the rejection status of a transplanted heart has been endomyocardial biopsy (EMB), which allows rejection to be screened for and monitored on the basis of the extent and distribution of lymphocytic infiltrates and associated myocardial damage. However, EMB has significant limitations: it is invasive, its sensitivity is limited by sampling efficacy, and it suffers from considerable between-observer variability. Although many noninvasive techniques have been investigated, none so far has proved able to match the performance of EMB. Currently, a multiparametric approach is employed that comprises clinical examination for signs or symptoms of heart failure, EMBs, drug level monitoring, allograft function tests (mainly echocardiographic studies), and screening for allograft vasculopathy. Gene expression profiling may be a promising tool for this purpose.

  14. Active Job Monitoring in Pilots

    NASA Astrophysics Data System (ADS)

    Kuehn, Eileen; Fischer, Max; Giffels, Manuel; Jung, Christopher; Petzold, Andreas

    2015-12-01

    Recent developments in high energy physics (HEP) including multi-core jobs and multi-core pilots require data centres to gain a deep understanding of the system to monitor, design, and upgrade computing clusters. Networking is a critical component. Especially the increased usage of data federations, for example in diskless computing centres or as a fallback solution, relies on WAN connectivity and availability. The specific demands of different experiments and communities, but also the need for identification of misbehaving batch jobs, requires an active monitoring. Existing monitoring tools are not capable of measuring fine-grained information at batch job level. This complicates network-aware scheduling and optimisations. In addition, pilots add another layer of abstraction. They behave like batch systems themselves by managing and executing payloads of jobs internally. The number of real jobs being executed is unknown, as the original batch system has no access to internal information about the scheduling process inside the pilots. Therefore, the comparability of jobs and pilots for predicting run-time behaviour or network performance cannot be ensured. Hence, identifying the actual payload is important. At the GridKa Tier 1 centre a specific tool is in use that allows the monitoring of network traffic information at batch job level. This contribution presents the current monitoring approach and discusses recent efforts and importance to identify pilots and their substructures inside the batch system. It will also show how to determine monitoring data of specific jobs from identified pilots. Finally, the approach is evaluated.

  15. Combined approach with therapeutic drug monitoring and pharmacogenomics in renal transplant recipients.

    PubMed

    Manvizhi, S; Mathew, B S; Fleming, D H; Basu, G; John, G T

    2013-01-01

    In patients undergoing renal transplantation, dose individualization for tacrolimus is routinely achieved with therapeutic drug monitoring (TDM). The patient started on 5.5 mg/day of tacrolimus had a significantly elevated tacrolimus trough concentration. The tacrolimus dose was regularly reduced following TDM at many time periods in the post transplant period but the tacrolimus concentration was consistently elevated. Genomic analysis done after four years revealed mutations in the genes encoding for CYP3A5 and MDR1 (2677G > T). Pharmacogenomics alongside TDM, will soon emerge as the backbone of dose individualization. But for genomics to be beneficial, it should be advocated in the pre-transplant or early post transplant period.

  16. Monitoring hemostasis parameters in left ventricular assist device recipients – a preliminary report

    PubMed Central

    Kaczmarski, Jacek; Pacholewicz, Jerzy; Zakliczyński, Michał; Gąsior, Mariusz; Zembala, Marian

    2016-01-01

    Introduction Mechanical circulatory support (MCS) therapy is associated with the improvement of long-term prognosis in patients with end-stage heart failure. For years it has been used as a bridge to transplant. However, more recently it is even being used as a destination therapy. Recently, clinicians have identified common MCS therapy-associated complications: pump thrombosis, bleeding, and hemolysis. These complications are very challenging with regard to both diagnosis and management. Aim To determine time-dependant changes of selected hemostasis/coagulation parameters in patients with end-stage heart failure treated with MCS and antithrombotic therapy. Material and methods Sixteen patients with end-stage heart failure on left ventricular assist device (LVAD) were followed for 6 weeks (six blood samples for each patient). Every week an extended hemostasis panel was assessed, including activated partial thromboplastin time, prothrombin time, international normalized ratio, von Willebrand factor (vWF) activity, factor VIII activity, fibrinogen level, D-dimer, platelet response to arachidonic acid (ASPI test) and adenosine diphosphate (ADP test), thrombin receptor activating peptide-6 (TRAP test) and collagen (COL test). Results The study population comprised 16 men. The median time from LVAD implantation was 120 days (100–150 days). During the study period the D-dimer and fibrinogen concentrations were elevated but remained similar throughout all six measurements. Meanwhile factor VIII and vWF activities were elevated in the first two measurements and then subsequently declined. Inhibition of platelet aggregation was greater early after LVAD implantation. During subsequent weeks the inhibition of platelet aggregation was less pronounced. No patient developed any bleeding or thrombo-embolic event during the study period. Conclusions Patients on MCS therapy demonstrate significant time-dependant changes in hemostasis parameters (both in the coagulation system and

  17. 24 CFR 1000.554 - Which agencies have right of access to the recipient's records relating to activities carried out...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Which agencies have right of access... agencies have right of access to the recipient's records relating to activities carried out under NAHASDA..., shall have the right of access to any pertinent books, documents, papers, or other records of...

  18. Tolerance of Organ Transplant Recipients to Physical Activity during a High-Altitude Expedition: Climbing Mount Kilimanjaro

    PubMed Central

    van Adrichem, Edwin J.; Siebelink, Marion J.; Rottier, Bart L.; Dilling, Janneke M.; Kuiken, Greetje; van der Schans, Cees P.; Verschuuren, Erik A. M.

    2015-01-01

    Background It is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls. Methods Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell- and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return. Results Eleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation. Conclusion Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls. PMID:26606048

  19. Pharmacokinetic and pharmacodynamic analysis of inosine monophosphate dehydrogenase activity in hematopoietic cell transplantation recipients treated with mycophenolate mofetil.

    PubMed

    Li, Hong; Mager, Donald E; Sandmaier, Brenda M; Storer, Barry E; Boeckh, Michael J; Bemer, Meagan J; Phillips, Brian R; Risler, Linda J; McCune, Jeannine S

    2014-08-01

    A novel approach to personalizing postgrafting immunosuppression in hematopoietic cell transplantation (HCT) recipients is evaluating inosine monophosphate dehydrogenase (IMPDH) activity as a drug-specific biomarker of mycophenolic acid (MPA)-induced immunosuppression. This prospective study evaluated total MPA, unbound MPA, and total MPA glucuronide plasma concentrations and IMPDH activity in peripheral blood mononuclear cells (PMNCs) at 5 time points after the morning dose of oral mycophenolate mofetil (MMF) on day +21 in 56 nonmyeloablative HCT recipients. Substantial interpatient variability in pharmacokinetics and pharmacodynamics was observed and accurately characterized by the population pharmacokinetic-dynamic model. IMPDH activity decreased with increasing MPA plasma concentration, with maximum inhibition coinciding with maximum MPA concentration in most patients. The overall relationship between MPA concentration and IMPDH activity was described by a direct inhibitory maximum effect model with an IC50 of 3.23 mg/L total MPA and 57.3 ng/mL unbound MPA. The day +21 IMPDH area under the effect curve (AUEC) was associated with cytomegalovirus reactivation, nonrelapse mortality, and overall mortality. In conclusion, a pharmacokinetic-dynamic model was developed that relates plasma MPA concentrations with PMNC IMPDH activity after an MMF dose in HCT recipients. Future studies should validate this model and confirm that day +21 IMPDH AUEC is a predictive biomarker.

  20. Anatahan Activity and Monitoring, 2005

    NASA Astrophysics Data System (ADS)

    Lockhart, A.; White, R.; Koyanagi, S.; Trusdell, F.; Kauahikaua, J.; Marso, J.; Ewert, J.

    2005-12-01

    Anatahan volcano began erupting in 2003 and continued with a second eruptive phase in 2004. In January 2005 the volcano began a sequence of eruptions and unrest that continues as of September 2005. The activity has been characterized by punctuated episodes of very steamy strombolian activity and vigorous ash emission. Some of the ash emissions have reached 50,000-foot elevations, with VOG and ash occasionally reaching the Philippines and southernmost Japan, over 1000 miles away. Vigorous ash emission has been almost continuous since June 2005. A M4.8 long-period earthquake (LP) occurred in mid-August, one of the largest LPs recorded on the planet in the last quarter-century. Real-time monitoring consisting of a few telemetered short-period seismometers and acoustic sensors has been severely hampered by ashfall on the small island. Monitoring efforts have been focused on the aircraft/ash hazard, with the goal of providing the FAA and airline industry with rapid notice of seismic signatures that may indicate ash columns rising to the altitude of airline traffic, or nominally above 20,000-30,000 ft.

  1. Active music engagement with emotional-approach coping to improve well-being in liver and kidney transplant recipients.

    PubMed

    Ghetti, Claire M

    2011-01-01

    Liver and kidney transplant recipients report elevated psychological distress following transplant in comparison to other types of organ transplant recipients. Negative affective states can lead to immune dysregulation and adverse health behaviors, and therefore may contribute to disease. In contrast, positive affective states can broaden individuals' thoughts and actions to promote the accumulation of coping resources. Coping strategies have traditionally been conceived of as being either problem-focused or emotion-focused in nature, while contemporary theory and research supports a different division: approach-oriented strategies versus avoidance-oriented strategies. Emotional expression and processing may function as an approach-oriented coping strategy. Emotional-approach coping relates to the use of emotional expression, awareness and understanding to facilitate coping with significant life stressors. The current study evaluated the impact of music therapy with and without a specific emphasis on emotional-approach coping. This randomized, controlled trial aimed to use Active Music Engagement with Emotional-Approach Coping to improve well-being in post-operative liver and kidney transplant recipients (N = 29). Results indicated that music therapy using Emotional-Approach Coping led to significant increases in positive affect, music therapy using Active Music Engagement led to significant decreases in pain, and both conditions led to significant decreases in negative affect, an indicator of perceived stress/anxiety.

  2. Plasma and urine renalase levels and activity during the recovery of renal function in kidney transplant recipients.

    PubMed

    Quelhas-Santos, Janete; Soares-Silva, Isabel; Fernandes-Cerqueira, Cátia; Simões-Silva, Liliana; Ferreira, Inês; Carvalho, Catarina; Coentrão, Luís; Vaz, Raquel; Sampaio-Maia, Benedita; Pestana, Manuel

    2014-04-01

    Renalase is a recently described enzyme secreted by the kidney into both plasma and urine, where it was suggested to degrade catecholamines contributing to blood pressure control. While there is a controversy regarding the relationship between renal function and plasma renalase levels, there is virtually no data in humans on plasma renalase activity as well as on both urine renalase levels and activity. We prospectively examined the time course of plasma and urine renalase levels and activity in 26 end-stage renal disease (ESRD) patients receiving a cadaver kidney transplant (cadaver kidney recipients [CKR]) before surgery and during the recovery of renal function up to day 90 post transplant. The relationship with sympathetic and renal dopaminergic activities was also evaluated. The recovery of renal function in CKR closely predicted decreases in plasma renalase levels (r = 0.88; P < 0.0001), urine renalase levels (r = 0.75; P < 0.0001) and urine renalase activity (r = 0.56; P < 0.03), but did not predict changes in plasma renalase activity (r = -0.02; NS). Plasma norepinephrine levels positively correlated with plasma renalase levels (r = 0.64, P < 0.002) as well as with urine renalase levels and activity (r = 0.47 P < 0.02; r = 0.71, P < 0.0005, respectively) and negatively correlated with plasma renalase activity (r = -0.57, P < 0.002). By contrast, plasma epinephrine levels positively correlated with plasma renalase activity (r = 0.67, P < 0.0001) and negatively correlated with plasma renalase levels (r = -0.62, P < 0.003). A significant negative relationship was observed between urine dopamine output and urine renalase levels (r = -0.48; P < 0.03) but not with urine renalase activity (r = -0.33, NS). We conclude that plasma and urine renalase levels closely depend on renal function and sympathetic nervous system activity. It is suggested that epinephrine-mediated activation of circulating renalase may occur in renal transplant recipients with good recovery of

  3. BK Virus Nephropathy in Heart Transplant Recipients.

    PubMed

    Joseph, Alin; Pilichowska, Monika; Boucher, Helen; Kiernan, Michael; DeNofrio, David; Inker, Lesley A

    2015-06-01

    Polyomavirus-associated nephropathy (PVAN) has become an important cause of kidney failure in kidney transplant recipients. PVAN is reported to affect 1% to 7% of kidney transplant recipients, leading to premature transplant loss in approximately 30% to 50% of diagnosed cases. PVAN occurring in the native kidneys of solid-organ transplant recipients other than kidney only recently has been noted. We report 2 cases of PVAN in heart transplant recipients, which brings the total of reported cases to 7. We briefly review the literature on the hypothesized causes of PVAN in kidney transplant recipients and comment on whether these same mechanisms also may cause PVAN in other solid-organ transplant recipients. PVAN should be considered in the differential diagnosis when evaluating worsening kidney function. BK viremia surveillance studies of nonkidney solid-organ recipients should be conducted to provide data to assist the transplantation community in deciding whether regular monitoring of nonkidney transplant recipients for BK viremia is indicated.

  4. Monitoring of intracellular adenosine triphosphate in CD4(+) T cells to predict the occurrence of cytomegalovirus disease in kidney transplant recipients.

    PubMed

    Pérez-Jacoiste Asín, María Asunción; Fernández-Ruiz, Mario; López-Medrano, Francisco; Aquilino, Carolina; González, Esther; Ruiz-Merlo, Tamara; Gutiérrez, Eduardo; San Juan, Rafael; Paz-Artal, Estela; Andrés, Amado; Aguado, José Maria

    2016-10-01

    The measurement of intracellular concentrations of adenosine triphosphate (iATP) in phytohemagglutinin-stimulated CD4(+) T cells constitutes a surrogate marker for post-transplant cell-mediated immunity (CMI). This assay has shown suboptimal accuracy for predicting infection after kidney transplantation (KT). We hypothesize that its predictive capacity depends on the specific contribution of the CMI to host-pathogen interactions. We assessed iATP levels in 100 KT recipients at baseline and months 1, 3, and 6 (363 measurements). No association was found between iATP at month 1 and the risk for overall or bacterial infection, although such association was evident for cytomegalovirus (CMV) disease (multivariate-adjusted hazard ratio [per 50-unit increment]: 0.83; P-value = 0.048). There were no significant differences in mean iATP between stable patients (319.4 ng/ml) and those developing overall (304.1 ng/ml) or bacterial infection (346.9 ng/ml) over the 45 days following monitoring. However, iATP was significantly lower in patients who developed CMV disease (223.5 ng/ml; P-values <0.002). The optimal cutoff (265 ng/ml) for predicting CMV disease in patients not receiving antiviral prophylaxis yielded sensitivity, specificity, positive, and negative predictive values of 85.7%, 68.3%, 15.2%, and 98.6%, respectively. In conclusion, a non-pathogen-specific monitoring of CMI by means of iATP informs the risk of CMV disease in KT recipients.

  5. Monitoring by Control Technique - Activated Carbon Adsorber

    EPA Pesticide Factsheets

    Stationary source emissions monitoring is required to demonstrate that a source is meeting the requirements in Federal or state rules. This page is about Activated Carbon Adsorber control techniques used to reduce pollutant emissions.

  6. Monitoring Biological Activity at Geothermal Power Plants

    SciTech Connect

    Peter Pryfogle

    2005-09-01

    The economic impact of microbial growth in geothermal power plants has been estimated to be as high as $500,000 annually for a 100 MWe plant. Many methods are available to monitor biological activity at these facilities; however, very few plants have any on-line monitoring program in place. Metal coupon, selective culturing (MPN), total organic carbon (TOC), adenosine triphosphate (ATP), respirometry, phospholipid fatty acid (PLFA), and denaturing gradient gel electrophoresis (DGGE) characterizations have been conducted using water samples collected from geothermal plants located in California and Utah. In addition, the on-line performance of a commercial electrochemical monitor, the BIoGEORGE?, has been evaluated during extended deployments at geothermal facilities. This report provides a review of these techniques, presents data on their application from laboratory and field studies, and discusses their value in characterizing and monitoring biological activities at geothermal power plants.

  7. Active personal radiation monitor for lunar EVA

    NASA Astrophysics Data System (ADS)

    Straume, Tore; Borak, Tom; Braby, L. A.; Lusby, Terry; Semones, Edward J.; Vazquez, Marcelo E.

    As astronauts return to the Moon-and this time, work for extended periods-there will be a critical need for crew personnel radiation monitoring as they operate lunar rovers or otherwise perform a myriad of extravehicular activities (EVAs). Our focus is on development of a small personal radiation monitor for lunar EVA that responds to the complex radiation quality and changing dose rates on the Moon. Of particular concern are active monitoring capabilities that provide both early warning and radiation dosimetry information during solar particle events (SPEs). To accomplish this, we are developing small detectors integrated with modern high speed, low power microelectronics to measure dose-rate and dose-mean lineal energy in real time. The monitor is designed to perform over the range of dose rates and LETs expected from both GCR and SPE radiations during lunar EVA missions. The monitor design provides simultaneous measurement of dose-equivalent rates at two tissue-equivalent depths simulating skin and marrow. The compact personal monitor is estimated to be the size of a cell phone and would fit on an EVA spacesuit (e.g., in backpack) or in a toolbox. The four-year development effort (which began December 2007) will result in a prototype radiation monitor field tested and characterized for the major radiations expected on the surface of the Moon. We acknowledge support from NSBRI through grants to NASA Ames Research Center (T. Straume, PI) and Colorado State University (T. Borak, PI).

  8. The World Transplant Games: an incentive to improve physical fitness and habitual activity in pediatric solid organ transplant recipients.

    PubMed

    Deliva, Robin D; Patterson, Catherine; So, Stephanie; Pellow, Vanessa; Miske, Stephanie; McLister, Carol; Manlhiot, Cedric; Pollock-BarZiv, Stacey; Drabble, Alison; Dipchand, Anne I

    2014-12-01

    This prospective, interventional study examined the impact of training for the WTG on levels of health-related physical fitness and habitual activity in a cohort of pediatric SOT recipients. Physical fitness (FitnessGram(®) ) and habitual activity (HAES) measures were performed on participants (n = 19) in the WTG and compared to non-participant controls (n = 14) prior to and following the WTG. Pre-WTG exercise training was provided to participants. Participants demonstrated a statistically significant improvement in their habitual weekday (6.1 ± 1.7 to 8.5 ± 1.9 h; p = 0.002) and weekend (6.3 ± 2.6 to 8.4 ± 2.5 h; p = 0.01) activity over the training period, while controls improved weekday activity only (6.3 ± 2.0 to 8.3 ± 2.1 h; p = 0.05. Weekend activity: 7.7 ± 2.7 to 8.3 ± 2.3 h; p = 0.68). Participants demonstrated a non-statistical improvement in select physical fitness parameters; however, a greater number of participants achieved healthy criterion standards for cardiovascular fitness (2 vs. 1), abdominal strength (5 vs. 3), and upper body strength (7 vs. 3) following training and participating in the WTG. The WTG can provide a positive incentive for greater levels of physical activity and promote improvements in physical fitness levels. Further study is needed to examine long-term impact on lifestyle changes and health outcomes.

  9. Is C2 monitoring or another limited sampling strategy superior to C0 monitoring in improving clinical outcomes in adult liver transplant recipients?

    PubMed

    Marin, Judith Geneviève; Levine, Marc; Ensom, Mary H H

    2006-10-01

    Cyclosporine (CsA) has had a major impact on the process and success of solid organ transplantation. Early in the use of CsA, therapeutic monitoring using the predose (trough, or C0) concentration became the standard of care. However, there are complications with the use of C0 monitoring that have only partly been mitigated with the advent of the micro-emulsion formulation (CsA-ME). More recently, limited sampling strategies (LSSs) for measuring the area under the CsA concentration-time curve (AUC) have been investigated to improve the monitoring of CsA post-transplantation. Many centres now routinely monitor CsA therapy using the concentration at 2 hours postdose (C2). In this paper the strength of the evidence for C2 (or other LSSs) relative to C0 monitoring of CsA-ME for improving clinically important outcomes in liver transplant patients is critically examined. Additionally, gaps in the literature are identified and recommendations are made for clinical research that could be done to provide more definitive evidence for the use of C2 or other LSSs in monitoring liver transplant patients.

  10. Norovirus Dynamics in Wastewater Discharges and in the Recipient Drinking Water Source: Long-Term Monitoring and Hydrodynamic Modeling.

    PubMed

    Dienus, Olaf; Sokolova, Ekaterina; Nyström, Fredrik; Matussek, Andreas; Löfgren, Sture; Blom, Lena; Pettersson, Thomas J R; Lindgren, Per-Eric

    2016-10-04

    Norovirus (NoV) that enters drinking water sources with wastewater discharges is a common cause of waterborne outbreaks. The impact of wastewater treatment plants (WWTPs) on the river Göta älv (Sweden) was studied using monitoring and hydrodynamic modeling. The concentrations of NoV genogroups (GG) I and II in samples collected at WWTPs and drinking water intakes (source water) during one year were quantified using duplex real-time reverse-transcription polymerase chain reaction. The mean (standard deviation) NoV GGI and GGII genome concentrations were 6.2 (1.4) and 6.8 (1.8) in incoming wastewater and 5.3 (1.4) and 5.9 (1.4) log10 genome equivalents (g.e.) L(-1) in treated wastewater, respectively. The reduction at the WWTPs varied between 0.4 and 1.1 log10 units. In source water, the concentration ranged from below the detection limit to 3.8 log10 g.e. L(-1). NoV GGII was detected in both wastewater and source water more frequently during the cold than the warm period of the year. The spread of NoV in the river was simulated using a three-dimensional hydrodynamic model. The modeling results indicated that the NoV GGI and GGII genome concentrations in source water may occasionally be up to 2.8 and 1.9 log10 units higher, respectively, than the concentrations measured during the monitoring project.

  11. 34 CFR 300.120 - Monitoring activities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Monitoring activities. 300.120 Section 300.120 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION...

  12. 34 CFR 300.120 - Monitoring activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Monitoring activities. 300.120 Section 300.120 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN...

  13. 34 CFR 300.120 - Monitoring activities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Monitoring activities. 300.120 Section 300.120 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION...

  14. 34 CFR 300.120 - Monitoring activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Monitoring activities. 300.120 Section 300.120 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION...

  15. 34 CFR 300.120 - Monitoring activities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Monitoring activities. 300.120 Section 300.120 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN...

  16. 34 CFR 359.11 - What activities must each recipient carry out under this program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REHABILITATION RESEARCH: SPECIAL PROJECTS AND DEMONSTRATIONS FOR SPINAL CORD INJURIES What Kinds of Activities... individuals with spinal cord injuries, including emergency medical services, acute care, vocational and other... those individuals with spinal cord injuries who might be served within that system; (c) Establish...

  17. 34 CFR 359.11 - What activities must each recipient carry out under this program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... REHABILITATION RESEARCH: SPECIAL PROJECTS AND DEMONSTRATIONS FOR SPINAL CORD INJURIES What Kinds of Activities... individuals with spinal cord injuries, including emergency medical services, acute care, vocational and other... those individuals with spinal cord injuries who might be served within that system; (c) Establish...

  18. Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored

    PubMed Central

    López, René; Arriagada, Elizabeth; Carrasco, René; Gallardo, Natalia; Lorca, Eduardo

    2017-01-01

    Background. Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. Methods. Forty-one stable Prograf (Astellas) receiving kidney transplant patients were switched to a generic tacrolimus (Sandoz) in a 1 : 1 dose ratio and were followed up for up to 8 months. All other drugs were maintained as per normal practice. Results. Neither tacrolimus doses nor their trough blood levels changed significantly after the switch, but serum creatinine did: 1.62 ± 0.90 versus 1.75 ± 0.92 mg/dL (p < 0.001). At the same time, five graft biopsies were performed, and two of them showed cellular acute rejection. There were nine infectious episodes treated satisfactorily with proper therapies. No patient or graft was lost during the follow-up time period. Conclusion. Switching from brand name tacrolimus to a generic tacrolimus (Sandoz) is feasible and appears to be safe, but it must be monitored carefully by treating physicians. PMID:28246556

  19. Variation in prescribing patterns and therapeutic drug monitoring of intravenous busulfan in pediatric hematopoietic cell transplant recipients.

    PubMed

    McCune, Jeannine S; Baker, K Scott; Blough, David K; Gamis, Alan; Bemer, Meagan J; Kelton-Rehkopf, Megan C; Winter, Laura; Barrett, Jeffrey S

    2013-03-01

    Personalizing intravenous (IV) busulfan doses in children using therapeutic drug monitoring (TDM) is an integral component of hematopoietic cell transplant. The authors sought to characterize initial dosing and TDM of IV busulfan, along with factors associated with busulfan clearance, in 729 children who underwent busulfan TDM from December 2005 to December 2008. The initial IV busulfan dose in children weighing ≤12 kg ranged 4.8-fold, with only 19% prescribed the package insert dose of 1.1 mg/kg. In those children weighing >12 kg, the initial dose ranged 5.4-fold, and 79% were prescribed the package insert dose. The initial busulfan dose achieved the target exposure in only 24.3% of children. A wide range of busulfan exposures were targeted for children with the same disease (eg, 39 target busulfan exposures for the 264 children diagnosed with acute myeloid leukemia). Considerable heterogeneity exists regarding when TDM is conducted and the number of pharmacokinetic samples obtained. Busulfan clearance varied by age and dosing frequency but not by underlying disease. The authors- group is currently evaluating how using population pharmacokinetics to optimize initial busulfan dose and TDM (eg, limited sampling schedule in conjunction with maximum a posteriori Bayesian estimation) may affect clinical outcomes in children.

  20. Variation in Prescribing Patterns and Therapeutic Drug Monitoring of Intravenous Busulfan in Pediatric Hematopoietic Cell Transplant Recipients

    PubMed Central

    McCune, Jeannine S.; Baker, K. Scott; Blough, David K.; Gamis, Alan; Bemer, Meagan J.; Kelton-Rehkopf, Megan C.; Winter, Laura; Barrett, Jeffrey S.

    2016-01-01

    Personalizing intravenous (IV) busulfan doses in children using therapeutic drug monitoring (TDM) is an integral component of hematopoietic cell transplant. The authors sought to characterize initial dosing and TDM of IV busulfan, along with factors associated with busulfan clearance, in 729 children who underwent busulfan TDM from December 2005 to December 2008. The initial IV busulfan dose in children weighing ≤12 kg ranged 4.8-fold, with only 19% prescribed the package insert dose of 1.1 mg/kg. In those children weighing >12 kg, the initial dose ranged 5.4-fold, and 79% were prescribed the package insert dose. The initial busulfan dose achieved the target exposure in only 24.3% of children. A wide range of busulfan exposures were targeted for children with the same disease (eg, 39 target busulfan exposures for the 264 children diagnosed with acute myeloid leukemia). Considerable heterogeneity exists regarding when TDM is conducted and the number of pharmacokinetic samples obtained. Busulfan clearance varied by age and dosing frequency but not by underlying disease. The authors’ group is currently evaluating how using population pharmacokinetics to optimize initial busulfan dose and TDM (eg, limited sampling schedule in conjunction with maximum a posteriori Bayesian estimation) may affect clinical outcomes in children. PMID:23444282

  1. Reporters to monitor cellular MMP12 activity

    NASA Astrophysics Data System (ADS)

    Cobos-Correa, Amanda; Mall, Marcus A.; Schultz, Carsten

    2010-02-01

    Macrophage elastase, also called MMP12, belongs to a family of proteolytic enzymes whose best known physiological function is the remodeling of the extracellular matrix. Under certain pathological conditions, including inflammation, chronic overexpression of MMP12 has been observed and its elevated proteolytic activity has been suggested to be the cause of pulmonary emphysema. However, it was until recently impossible to monitor the activity of MMP12 under disease conditions, mainly due to a lack of detection methods. Recent development of new reporters for monitoring MMP12 activity in living cells, such as LaRee1, provided novel insights into the pathobiology of MMP12 in pulmonary inflammation.1 In the future, these reporters might contribute to improved diagnosis and in finding better treatments for chronic inflammatory lung diseases and emphysema. Our approach for visualizing MMP12 activity is based on peptidic, membrane-targeted FRET (Foerster Resonance Energy Transfer) reporters. Here we describe a set of new reporters containing different fluorophore pairs as well as modifications in the membrane-targeting lipid moiety. We studied the influence of these modifications on reporter performance and the reporter mobility on live cell membranes by FRAP (fluorescence recovery after photobleaching). Finally, we generated several new fluorescently labeled MMP inhibitors based on the peptidic reporter structures as prototypes for future tools to inhibit and monitor MMP activity at the same time.

  2. Evolution of impedance field telemetry after one day of activation in cochlear implant recipients

    PubMed Central

    Tsai, Chia-Mi; Chen, Hsing-Yi; Tung, Tao-Hsin; Li, Lieber Po-Hung

    2017-01-01

    Objectives Changes in impedance between 24 hours and one month after cochlear implantation have never been explored due to the inability to switch on within one day. This study examined the effect of early activation (within 24 hours) on the evolution of electrode impedance with the aim of providing information on the tissue-to-electrode interface when electrical stimulation was commenced one day post implantation. Methods We performed a retrospective review at a single institution. Patients who received a Nucleus 24RECA implant system (Cochlear, Sydney, Australia) and underwent initial switch-on within 24 hours postoperatively were included. Impedance measurements were obtained intraoperatively and postoperatively at 1 day, 1 week, 4 weeks, and 8 weeks. Results A significant drop in impedance was noted 1 day after an initial activation within 24 hours followed by a significant rise in impedance in all channels until 1 week, after which the impedance behaved differently in different segments. Basal and mid-portion electrodes revealed a slight increase while apical electrodes showed a slight decrease in impedance from 1 week to 8 weeks postoperatively. Impedance was relatively stable 4 weeks after surgery. Conclusions This is the first study to report the evolution of impedance in all channels between initial mapping 1 day and 1 month after cochlear implantation. The underlying mechanism for the differences in behavior between different segments of the electrode may be associated with the combined effect of dynamics among the interplay of cell cover formation, electrical stimulation, and fibrotic reaction. PMID:28264044

  3. Active Sites Environmental Monitoring Program: Program plan

    SciTech Connect

    Ashwood, T.L.; Wickliff, D.S.; Morrissey, C.M.

    1992-02-01

    The Active Sites Environmental Monitoring Program (ASEMP), initiated in 1989, provides early detection and performance monitoring of transuranic (TRU) waste and active low-level waste (LLW) facilities at Oak Ridge National Laboratory (ORNL) in accordance with US Department of Energy (DOE) Order 5820.2A. Active LLW facilities in Solid Waste Storage Area (SWSA) 6 include Tumulus I and Tumulus II, the Interim Waste Management Facility (IWMF), LLW silos, high-range wells, asbestos silos, and fissile wells. The tumulus pads and IWMF are aboveground, high-strength concrete pads on which concrete vaults containing metal boxes of LLW are placed; the void space between the boxes and vaults is filled with grout. Eventually, these pads and vaults will be covered by an engineered multilayered cap. All other LLW facilities in SWSA 6 are below ground. In addition, this plan includes monitoring of the Hillcut Disposal Test Facility (HDTF) in SWSA 6, even though this facility was completed prior to the data of the DOE order. In SWSA 5 North, the TRU facilities include below-grade engineered caves, high-range wells, and unlined trenches. All samples from SWSA 6 are screened for alpha and beta activity, counted for gamma-emitting isotopes, and analyzed for tritium. In addition to these analytes, samples from SWSA 5 North are analyzed for specific transuranic elements.

  4. Somatic cell cloning in Buffalo (Bubalus bubalis): effects of interspecies cytoplasmic recipients and activation procedures.

    PubMed

    Kitiyanant, Y; Saikhun, J; Chaisalee, B; White, K L; Pavasuthipaisit, K

    2001-01-01

    Successful nuclear transfer (NT) of somatic cell nuclei from various mammalian species to enucleated bovine oocytes provides a universal cytoplast for NT in endangered or extinct species. Buffalo fetal fibroblasts were isolated from a day 40 fetus and were synchronized in presumptive G(0) by serum deprivation. Buffalo and bovine oocytes from abattoir ovaries were matured in vitro and enucleated at 22 h. In the first experiment, we compared the ability of buffalo and bovine oocyte cytoplasm to support in vitro development of NT embryos produced by buffalo fetal fibroblasts as donor nuclei. There were no significant differences (p > 0.05) between the NT embryos derived from buffalo and bovine oocytes, in fusion (74% versus 71%) and cleavage (77% versus 75%) rates, respectively. No significant differences were also observed in blastocyst development (39% versus 33%) and the mean cell numbers of day 7 cloned blastocysts (88.5 +/- 25.7 versus 51.7 +/- 5.4). In the second experiment, we evaluated the effects of activation with calcium ionophore A23187 on development of NT embryos after electrical fusion. A significantly higher (p < 0.05) percentage of blastocyst development was observed in the NT embryos activated by calcium ionophore and 6-DMAP when compared with 6-DMAP alone (33% versus 17%). The results indicate that the somatic nuclei from buffalo can be reprogrammed after transfer to enucleated bovine oocytes, resulting in the production of cloned buffalo blastocysts similar to those transferred into buffalo oocytes. Calcium ionophore used in conjunction with 6-DMAP effectively induces NT embryo development.

  5. Physical activity in solid organ transplant recipients: organizational aspects and preliminary results of the Italian project.

    PubMed

    Roi, G S; Stefoni, S; Mosconi, G; Brugin, E; Burra, P; Ermolao, A; Granito, M; Macini, P; Mastrosimone, S; Nacchia, F; Pegoraro, C; Rigotti, P; Sella, G; Sgarzi, S; Tamè, M R; Totti, V; Trerotola, M; Tripi, F; Nanni Costa, A

    2014-09-01

    Most of the difficulties when trying to realize the proposal to prescribe physical activity for transplantation patients come from patient attitudes and cultural beliefs that ignore the benefits of exercise, but there also are organizational aspects arising from the difficulties that these patients face in accessing supervised exercise facilities. To address these difficulties, the Italian study project "Transplant … and Now Sport" was developed based on a model of cooperation among transplantation specialists, sports physicians, and exercise specialists organized as a team combining their specific skills to effectively actuate the physical exercise programs. This preliminary report is based on 26 patients (16 male, 10 female; 47.8±10.0 years old; 21 kidney and 5 liver transplantations; time from transplantation 2.3±1.4 years) who performed prescribed and supervised exercises consisting of 3 sessions per week of aerobic and strengthening exercises for 1 year. Preliminary results show a significant decrease in body mass index (t=1.966; P<.05) and a significant increase in peak aerobic power (t=4.535; P<.01) and maximum workload (t=4.665; P<.01) on the incremental cycling test. Also maximum strength of knee extensors (t=2.933; P<.05) and elbow flexors (t=2.450; P<.05) and countermovement jump performance (t=2.303; P<.05) significantly increased. Creatinine and proteinuria tended to decrease, but the differences were not significant. In health-related quality of life assessed by the SF-36 questionnaire, the Bodily Pain, General Health, Vitality, Social Functioning, and Role Emotional scale scores showed a significant improvement (P<.05). Preliminary results of the study protocol "Transplant…and Now Sport" show the positive effects of the model based on cooperation among transplantation centers, sports medicine centers, and gyms in the administration of a supervised exercise prescription. These data should be considered a contribution to developing and promoting

  6. Regenerable activated bauxite adsorbent alkali monitor probe

    DOEpatents

    Lee, Sheldon H. D.

    1992-01-01

    A regenerable activated bauxite adsorber alkali monitor probe for field applications to provide reliable measurement of alkali-vapor concentration in combustion gas with special emphasis on pressurized fluidized-bed combustion (PFBC) off-gas. More particularly, the invention relates to the development of a easily regenerable bauxite adsorbent for use in a method to accurately determine the alkali-vapor content of PFBC exhaust gases.

  7. [A monitor of the biomechanical cardiac activity].

    PubMed

    Masloboev, Iu P; Okhritskiĭ, A A; Prilutskiĭ, D A; Selishchev, S V

    2004-01-01

    A monitor of the biomechanical cardiac activity is described, which was elaborated on the basis of the accelerometer sensor and sigma-delta ADC for the purpose of registering the ballistocardiograms and seismocardiograms. The device ensures a non-stop signal recording for as long as 8 hours with the data being preserved in an inbuilt memory. Data are fed to the computer through the USB port. An algorithm is suggested for recordings processing by using the neuron-net technologies.

  8. Regenerable activated bauxite adsorbent alkali monitor probe

    SciTech Connect

    Lee, S.H.D.

    1991-01-22

    This invention relates to a regenerable activated bauxite adsorber alkali monitor probe for field applications to provide reliable measurement of alkali-vapor 5 concentration in combustion gas with special emphasis on pressurized fluidized-bed combustion (PFBC) off-gas. More particularly, the invention relates to the development of a easily regenerable bauxite adsorbent for use in a method to accurately determine the alkali-vapor content of PFBC 10 exhaust gases.

  9. Regenerable activated bauxite adsorbent alkali monitor probe

    DOEpatents

    Lee, S.H.D.

    1992-12-22

    A regenerable activated bauxite adsorber alkali monitor probe for field applications to provide reliable measurement of alkali-vapor concentration in combustion gas with special emphasis on pressurized fluidized-bed combustion (PFBC) off-gas. More particularly, the invention relates to the development of a easily regenerable bauxite adsorbent for use in a method to accurately determine the alkali-vapor content of PFBC exhaust gases. 6 figs.

  10. Activity monitor accuracy in persons using canes.

    PubMed

    Wendland, Deborah Michael; Sprigle, Stephen H

    2012-01-01

    The StepWatch activity monitor has not been validated on multiple indoor and outdoor surfaces in a population using ambulation aids. The aims of this technical report are to report on strategies to configure the StepWatch activity monitor on subjects using a cane and to report the accuracy of both leg-mounted and cane-mounted StepWatch devices on people ambulating over different surfaces while using a cane. Sixteen subjects aged 67 to 85 yr (mean 75.6) who regularly use a cane for ambulation participated. StepWatch calibration was performed by adjusting sensitivity and cadence. Following calibration optimization, accuracy was tested on both the leg-mounted and cane-mounted devices on different surfaces, including linoleum, sidewalk, grass, ramp, and stairs. The leg-mounted device had an accuracy of 93.4% across all surfaces, while the cane-mounted device had an aggregate accuracy of 84.7% across all surfaces. Accuracy of the StepWatch on the stairs was significantly less accurate (p < 0.001) when comparing surfaces using repeated measures analysis of variance. When monitoring community mobility, placement of a StepWatch on a person and his/her ambulation aid can accurately document both activity and device use.

  11. Effects of recipient oocyte age and interval from fusion to activation on development of buffalo (Bubalus bubalis) nuclear transfer embryos derived from fetal fibroblasts.

    PubMed

    Lu, F; Jiang, J; Li, N; Zhang, S; Sun, H; Luo, C; Wei, Y; Shi, D

    2011-09-15

    The objective was to investigate the effect of recipient oocyte age and the interval from activation to fusion on developmental competence of buffalo nuclear transfer (NT) embryos. Buffalo oocytes matured in vitro for 22 h were enucleated by micromanipulation under the spindle view system, and a fetal fibroblast (pretreated with 0.1 μg/mL aphidicolin for 24 h, followed by culture for 48 h in 0.5% fetal bovine serum) was introduced into the enucleated oocyte, followed by electrofusion. Both oocytes and NT embryos were activated by exposure to 5 μM ionomycin for 5 min, followed by culture in 2 mM 6-dimethyl-aminopurine for 3 h. When oocytes matured in vitro for 28, 29, 30, 31, or 32 h were activated, more oocytes matured in vitro for 30 h developed into blastocysts in comparison with oocytes matured in vitro for 32 h (31.3 vs 19.9%, P < 0.05). When electrofusion was induced 27 h after the onset of oocyte maturation, the cleavage rate (78.0%) was higher than that of electrofusion induced at 28 h (67.2%, P < 0.05), and the blastocyst yield (18.1%) was higher (P < 0.05) than that of electrofusion induced at 25 or 26 h (7.4 and 8.5%, respectively). A higher proportion of NT embryos activated at 3 h after electrofusion developed to the blastocyst stage (18.6%) in comparison with NT embryos activated at 1 h (6.0%), 2 h (8.3%), or 4 h (10.6%) after fusion (P < 0.05). No recipient was pregnant 60 d after transfer of blastocysts developed from NT embryos activated at 1 h (0/8), 2 h (0/10), or 4 h (0/9) after fusion. However, 3 of 16 recipients were pregnant following transfer of blastocysts developed from the NT embryos activated at 3 h after fusion, and two of these recipients maintained pregnancy to term. We concluded that the developmental potential of buffalo NT embryos was related to recipient oocyte age and the interval from fusion to activation.

  12. First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 5: recipient monitoring and response plan for preventing disease transmission.

    PubMed

    Denner, Joachim; Tönjes, Ralf R; Takeuchi, Yasu; Fishman, Jay; Scobie, Linda

    2016-01-01

    Xenotransplantation of porcine cells, tissues, and organs may be associated with the transmission of porcine microorganisms to the human recipient. A previous, 2009, version of this consensus statement focused on strategies to prevent transmission of porcine endogenous retroviruses (PERVs). This version addresses potential transmission of all porcine microorganisms including monitoring of the recipient and provides suggested approaches to the monitoring and prevention of disease transmission. Prior analyses assumed that most microorganisms other than the endogenous retroviruses could be eliminated from donor animals under appropriate conditions which have been called "designated pathogen-free" (DPF) source animal production. PERVs integrated as proviruses in the genome of all pigs cannot be eliminated in that manner and represent a unique risk. Certain microorganisms are by nature difficult to eliminate even under DPF conditions; any such clinically relevant microorganisms should be included in pig screening programs. With the use of porcine islets in clinical trials, special consideration has to be given to the presence of microorganisms in the isolated islet tissue to be used and also to the potential use of encapsulation. It is proposed that microorganisms absent in the donor animals by sensitive microbiological examination do not need to be monitored in the transplant recipient; this will reduce costs and screening requirements. Valid detection assays for donor and manufacturing-derived microorganisms must be established. Special consideration is needed to preempt potential unknown pathogens which may pose a risk to the recipient. This statement summarizes the main achievements in the field since 2009 and focus on issues and solutions with microorganisms other than PERV.

  13. System and method for monitoring cellular activity

    NASA Technical Reports Server (NTRS)

    Bearman, Gregory H. (Inventor); Fraser, Scott E. (Inventor); Lansford, Russell D. (Inventor)

    2004-01-01

    A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser microscope is provided to excite a region of the specimen and cause fluorescence to be radiated from the region. The radiating fluorescence is processed by a spectral analyzer to separate the fluorescence into respective wavelength bands. The respective bands of fluorescence are then collected by an array of detectors, with each detector receiving a corresponding one of the wavelength bands.

  14. System and method for monitoring cellular activity

    NASA Technical Reports Server (NTRS)

    Bearman, Gregory H. (Inventor); Fraser, Scott E. (Inventor); Lansford, Russell D. (Inventor)

    2002-01-01

    A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser microscope is provided to excite a region of the specimen and cause fluorescence to be radiated from the region. The radiating fluorescence is processed by a spectral analyzer to separate the fluorescence into respective wavelength bands. The respective bands of fluorescence are then collected by an array of detectors, with each detector receiving a corresponding one of the wavelength bands.

  15. Terms and conditions for Diesel Emissions Reduction Act Smartway financing projects where an eligible nonprofit grantee is implementing a loan program and loan Recipients will use the loan funds for activities that trigger Davis Bacon

    EPA Pesticide Factsheets

    Use this T&C for DERA Smartway financing projects where an eligible nonprofit grantee is implementing a loan program and loan Recipients will use the loan funds for activities that trigger Davis Bacon.

  16. Quality Assurance Project Plan for Facility Effluent Monitoring Plan activities

    SciTech Connect

    Frazier, T.P.

    1994-10-20

    This Quality Assurance Project Plan addresses the quality assurance requirements for the activities associated with the Facility Effluent Monitoring Plans, which are part of the overall Hanford Site Environmental Protection Plan. This plan specifically applies to the sampling and analysis activities and continuous monitoring performed for all Facility Effluent Monitoring Plan activities conducted by Westinghouse Hanford Company. It is generic in approach and will be implemented in conjunction with the specific requirements of the individual Facility Effluent Monitoring Plans.

  17. Multiwavelength monitoring of active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Urry, C. M.

    1993-01-01

    Recent multiwavelength monitoring of active galactic nuclei (AGN), particularly with the IUE satellite, has produced extraordinay advances in our understanding of the energy-generation mechanism(s) in the central engine and of the structure of the surrounding material. Examples discussed here include both ordinary AGN and blazars (the collective name for highly variable, radio-loud AGN like BL Lac objects and Optically Violently Variable quasars). In the last decade, efforts to obtain single-epoch multiwavelength spectra led to fundamentally new models for the structure of AGN, involving accretion disks for AGN and relativistic jets for blazars. Recent extensions of multiwavelength spectroscopy into the temporal domain have shown that while these general pictures may be correct, the details were probably wrong. Campaigns to monitor Seyfert 1 galaxies like NGC 4151, NGC 5548 and Fairall 9 at infrared, optical, ultraviolet and X-ray wavelengths indicate that broad-emission line regions are stratified by ionization, density, and velocity; argue against a standard thin accretion disk model; and suggest that X-rays represent primary rather than reprocessed radiation. For blazars, years of radio monitoring indicated emission from an inhomogeneous synchrotron-emitting plasma, which could also produce at least some of the shorter-wavelength emission. The recent month-long campaign to observe the BL Lac object PKS 2155-304 has revealed remarkably rapid variability that extends from the infrared through the X-ray with similar amplitude and little or no discernible lag. This lends strong support to relativistic jet models and rules out the proposed accretion disk model for the ultraviolet-X-ray continuum.

  18. Monitoring of Crew Activity with FAMOS

    NASA Astrophysics Data System (ADS)

    Wolf, L.; Cajochen, C.; Bromundt, V.

    2007-10-01

    The success of long duration space missions, such as manned missions to Mars, depends on high and sustained levels of vigilance and performance of astronauts and operators working in the technology rich environment of a spacecraft. Experiment 'Monitoring of Crew Activity with FAMOS' was set up to obtain operational experience with complimentary methods / technologies to assess the alertness / sleepiness status of selected AustroMars crewmembers on a daily basis. We applied a neurobehavioral test battery consisting of 1) Karolinska Sleepiness Scale KSS, 2) Karolinska Drowsiness Test KDT, 3) Psychomotor Vigilance Task PVT, combined with 4) left eye video recordings with an early prototype of the FAMOS Fatigue Monitoring System headset currently being developed by Sowoon Technologies (CH), and 5) Actiwatches that were worn continuously. A test battery required approximately 15 minutes and was repeated up to 4 times daily by 2 to 4 subjects. Here we present the data analysis of methods 1, 2, 3, and 5, while data analysis of method 4 is still in progress.

  19. Active chaotic excitation for bolted joint monitoring

    NASA Astrophysics Data System (ADS)

    Fasel, Timothy R.; Todd, Michael D.; Park, Gyuhae

    2006-03-01

    Recent research has shown that high frequency chaotic excitation and state space reconstruction may be used to identify incipient damage (loss of preload) in a bolted joint. In this study, a new experiment is undertaken with updated test equipment, including a piezostack actuator that allows for precise control of bolt preload. The excitation waveform is applied to a macro-fiber composite (MFC) patch that is bonded to the test structure and is sensed in an active manner using a second MFC patch. A novel prediction error algorithm, based on comparing filtered properties of the guided chaotic waves, is used to determine the damage state of a frame structure and is shown to be highly sensitive to small levels of bolt preload loss. The performance of the prediction error method is compared with standard structural health monitoring damage features that are based on time series analysis using auto-regressive (AR) models.

  20. An Automatic Tremor Activity Monitoring System (TAMS)

    NASA Astrophysics Data System (ADS)

    Kao, H.; Thompson, P. J.; Rogers, G.; Dragert, H.; Spence, G.

    2006-12-01

    We have developed an algorithm that quantitatively characterizes the level of seismic tremors from recorded seismic waveforms. For each hour of waveform at a given station, the process begins with the calculation of scintillation index and moving average with various time lengths. The scintillation index (essentially the `normalized variance of intensity of the signal') is adapted from the studies of pulses in radio waves and is an efficient tool to identify the energy bursts of tremor signals. Both scintillation index and moving average values are fed into a series of logic gates to determine if tremor activity exists. This algorithm is implemented in the Tremor Activity Monitoring System (TAMS) to provide automatic early alerts for episodic tremor and slip (ETS) events in the northern Cascadia margin. Currently, TAMS retrieves the digital waveforms recorded during the previous day from the Canadian National Seismographic Network (CNSN) archive server at 1 AM every morning. The detecting process is repeated for all stations and hours to determine the level of tremor activity of the previous day. If a sufficient number of stations within a radius of 100 km are determined to have tremor patterns and coherent tremor arrivals can be found at more than 3 stations, TAMS automatically sends out alert emails to a list of subscribers with a figure summarizing the hours and locations of coherent tremors. TAMS outputs are very consistent with the work done by visual inspection, especially for major ETS events. It is straightforward to configure TAMS into a near-real-time system that can send out hourly (or shorter) reports if necessary.

  1. How consumer physical activity monitors could transform human physiology research.

    PubMed

    Wright, Stephen P; Hall Brown, Tyish S; Collier, Scott R; Sandberg, Kathryn

    2017-03-01

    A sedentary lifestyle and lack of physical activity are well-established risk factors for chronic disease and adverse health outcomes. Thus, there is enormous interest in measuring physical activity in biomedical research. Many consumer physical activity monitors, including Basis Health Tracker, BodyMedia Fit, DirectLife, Fitbit Flex, Fitbit One, Fitbit Zip, Garmin Vivofit, Jawbone UP, MisFit Shine, Nike FuelBand, Polar Loop, Withings Pulse O2, and others have accuracies similar to that of research-grade physical activity monitors for measuring steps. This review focuses on the unprecedented opportunities that consumer physical activity monitors offer for human physiology and pathophysiology research because of their ability to measure activity continuously under real-life conditions and because they are already widely used by consumers. We examine current and potential uses of consumer physical activity monitors as a measuring or monitoring device, or as an intervention in strategies to change behavior and predict health outcomes. The accuracy, reliability, reproducibility, and validity of consumer physical activity monitors are reviewed, as are limitations and challenges associated with using these devices in research. Other topics covered include how smartphone apps and platforms, such as the Apple ResearchKit, can be used in conjunction with consumer physical activity monitors for research. Lastly, the future of consumer physical activity monitors and related technology is considered: pattern recognition, integration of sleep monitors, and other biosensors in combination with new forms of information processing.

  2. A System for Monitoring Posture and Physical Activity Using Accelerometers

    DTIC Science & Technology

    2007-11-02

    Abstract- Accelerometers can be used to monitor physical activity in the home over prolonged periods. We describe a novel system for...processing schema in which these parameters are extracted is described. Keywords - physical activity , accelerometers, congestive heart failure, chronic...When monitoring the condition of patients with neurodegenerative or chronic diseases, a knowledge of their body movement and physical activity

  3. 34 CFR 110.24 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Recipient assessment of age distinctions. 110.24..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of ED Recipients § 110.24 Recipient assessment of age distinctions. (a) As...

  4. 34 CFR 110.24 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Recipient assessment of age distinctions. 110.24..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of ED Recipients § 110.24 Recipient assessment of age distinctions. (a) As...

  5. 34 CFR 110.24 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Recipient assessment of age distinctions. 110.24..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of ED Recipients § 110.24 Recipient assessment of age distinctions. (a) As...

  6. 34 CFR 110.24 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Recipient assessment of age distinctions. 110.24..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of ED Recipients § 110.24 Recipient assessment of age distinctions. (a) As...

  7. 34 CFR 110.24 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Recipient assessment of age distinctions. 110.24..., DEPARTMENT OF EDUCATION NONDISCRIMINATION ON THE BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of ED Recipients § 110.24 Recipient assessment of age distinctions. (a) As...

  8. 45 CFR 1610.8 - Program integrity of recipient.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (a) A recipient must have objective integrity and independence from any organization that engages in restricted activities. A recipient will be found to have objective integrity and independence from such an... present. (b) Each recipient's governing body must certify to the Corporation within 180 days of...

  9. 45 CFR 1610.8 - Program integrity of recipient.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (a) A recipient must have objective integrity and independence from any organization that engages in restricted activities. A recipient will be found to have objective integrity and independence from such an... present. (b) Each recipient's governing body must certify to the Corporation within 180 days of...

  10. Deformation Monitoring of AN Active Fault

    NASA Astrophysics Data System (ADS)

    Ostapchuk, A.

    2015-12-01

    The discovery of low frequency earthquakes, slow slip events and other deformation phenomena, new for geophysics, change our understanding of how the energy accumulated in the Earth's crust do release. The new geophysical data make one revise the underlying mechanism of geomechanical processes taking place in fault zones. Conditions for generating different slip modes are still unclear. The most vital question is whether a certain slip mode is intrinsic for a fault or may be controlled by external factors. This work presents the results of two and a half year deformation monitoring of a discontinuity in the zone of the Main Sayanskiy Fault. Main Sayanskiy Fault is right-lateral strike-slip fault. Observations were performed in the tunnel of Talaya seismic station (TLY), Irkutsk region, Russia. Measurements were carried out 70 m away from the entrance of the tunnel, the thickness of overlying rock was about 30 m. Inductive sensors of displacement were mounted at the both sides of a discontinuity, which recorded three components of relative fault side displacement with the accuracy of 0.2 mcm. Temperature variation inside the tunnel didn't exceed 0.5oC during the all period of observations. Important information about deformation properties of an active fault was obtained. A pronounced seasonality of deformation characteristics of discontinuity is observed in the investigated segment of rock. A great number of slow slip events with durations from several hours to several weeks were registered. Besides that alterations of fault deformation characteristics before the megathrust earthquake M9.0 Tohoku Oki 11 March 2011 and reaction to the event itself were detected. The work was supported by the Russian Science Foundation (grant no. 14-17-00719).

  11. Geophysical Mapping and Monitoring of Active Planets (GMAP)

    NASA Astrophysics Data System (ADS)

    McGovern, P. J.; Goossens, S. J.; Lemoine, F. G.

    2017-02-01

    Recent findings require a strongly upward revision of volcano-tectonic activity rate estimates for Venus and Mars. We propose a program of Geophysical Mapping and Monitoring of Active Planets (GMAP) including seismology, gravimetry, InSAR, and GPS.

  12. Instructional physical activity monitor video in english and spanish

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The ActiGraph activity monitor is a widely used method for assessing physical activity. Compliance with study procedures in critical. A common procedure is for the research team to meet with participants and demonstrate how and when to attach and remove the monitor and convey how many wear-days are ...

  13. Quality Assurance Project Plan for Facility Effluent Monitoring Plan activities

    SciTech Connect

    Nickels, J.M.

    1991-06-01

    This Quality Assurance Project Plan addresses the quality assurance requirements for the Facility Monitoring Plans of the overall site-wide environmental monitoring plan. This plan specifically applies to the sampling and analysis activities and continuous monitoring performed for all Facility Effluent Monitoring Plan activities conducted by Westinghouse Hanford Company. It is generic in approach and will be implemented in conjunction with the specific requirements of individual Facility Effluent Monitoring Plans. This document is intended to be a basic road map to the Facility Effluent Monitoring Plan documents (i.e., the guidance document for preparing Facility Effluent Monitoring Plans, Facility Effluent Monitoring Plan determinations, management plan, and Facility Effluent Monitoring Plans). The implementing procedures, plans, and instructions are appropriate for the control of effluent monitoring plans requiring compliance with US Department of Energy, US Environmental Protection Agency, state, and local requirements. This Quality Assurance Project Plan contains a matrix of organizational responsibilities, procedural resources from facility or site manuals used in the Facility Effluent Monitoring Plans, and a list of the analytes of interest and analytical methods for each facility preparing a Facility Effluent Monitoring Plan. 44 refs., 1 figs., 2 tabs.

  14. Lipids in liver transplant recipients

    PubMed Central

    Hüsing, Anna; Kabar, Iyad; Schmidt, Hartmut H

    2016-01-01

    Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. Due to recent improvements in survival of liver transplant recipients, the prevention of cardiovascular events has become more important, especially as approximately 64% of liver transplant recipients present with an increased risk of cardiovascular events. Management of dyslipidemia and of other modifiable cardiovascular risk factors, such as hypertension, diabetes and smoking, has therefore become essential in these patients. Treatment of hyperlipidemia after liver transplantation consists of life style modification, modifying the dose or type of immunosuppressive agents and use of lipid lowering agents. At the start of administration of lipid lowering medications, it is important to monitor drug-drug interactions, especially between lipid lowering agents and immunosuppressive drugs. Furthermore, as combinations of various lipid lowering drugs can lead to severe side effects, such as myopathies and rhabdomyolysis, these combinations should therefore be avoided. To our knowledge, there are no current guidelines targeting the management of lipid metabolism disorders in liver transplant recipients. This paper therefore recommends an approach of managing lipid abnormalities occurring after liver transplantation. PMID:27022213

  15. Remote Physical Activity Monitoring in Neurological Disease: A Systematic Review

    PubMed Central

    Block, Valerie A. J.; Pitsch, Erica; Tahir, Peggy; Cree, Bruce A. C.; Allen, Diane D.; Gelfand, Jeffrey M.

    2016-01-01

    Objective To perform a systematic review of studies using remote physical activity monitoring in neurological diseases, highlighting advances and determining gaps. Methods Studies were systematically identified in PubMed/MEDLINE, CINAHL and SCOPUS from January 2004 to December 2014 that monitored physical activity for ≥24 hours in adults with neurological diseases. Studies that measured only involuntary motor activity (tremor, seizures), energy expenditure or sleep were excluded. Feasibility, findings, and protocols were examined. Results 137 studies met inclusion criteria in multiple sclerosis (MS) (61 studies); stroke (41); Parkinson's Disease (PD) (20); dementia (11); traumatic brain injury (2) and ataxia (1). Physical activity levels measured by remote monitoring are consistently low in people with MS, stroke and dementia, and patterns of physical activity are altered in PD. In MS, decreased ambulatory activity assessed via remote monitoring is associated with greater disability and lower quality of life. In stroke, remote measures of upper limb function and ambulation are associated with functional recovery following rehabilitation and goal-directed interventions. In PD, remote monitoring may help to predict falls. In dementia, remote physical activity measures correlate with disease severity and can detect wandering. Conclusions These studies show that remote physical activity monitoring is feasible in neurological diseases, including in people with moderate to severe neurological disability. Remote monitoring can be a psychometrically sound and responsive way to assess physical activity in neurological disease. Further research is needed to ensure these tools provide meaningful information in the context of specific neurological disorders and patterns of neurological disability. PMID:27124611

  16. Raw and biologically treated paper mill wastewater effluents and the recipient surface waters: Cytotoxic and genotoxic activity and the presence of endocrine disrupting compounds.

    PubMed

    Balabanič, Damjan; Filipič, Metka; Krivograd Klemenčič, Aleksandra; Žegura, Bojana

    2017-01-01

    Paper mill effluents are complex mixtures containing different toxic compounds including endocrine-disrupting (EDCs) and genotoxic compounds. In the present study non-concentrated raw and biologically treated wastewaters from two paper mill plants with different paper production technologies i) Paper mill A uses virgin fibres, and ii) Paper mill B uses recycled fibres for paper production and the corresponding receiving surface waters, were assessed for their cytotoxic/genotoxic activity with SOS/umuC, Ames MPF 98/100 Aqua, and comet assay with human hepatoma HepG2 cells. In addition the levels of seven selected EDCs were quantified in wastewater samples and receiving surface waters. All investigated EDCs were confirmed in raw and biologically treated effluents from both paper mills with concentrations being markedly higher in Paper mill B effluents. In the receiving surface waters three of the studied EDCs were determined downstream of both paper mills effluent discharge. The wastewater samples and the recipient surface water samples from Paper mill A were not mutagenic for bacteria and did not induce DNA damage in HepG2 cells. On the contrary, half of the raw wastewater samples from Paper mill B were mutagenic whereas biologically treated wastewater and the recipient surface water samples were negative. In HepG2 cells most of the raw and biologically treated wastewater samples from Paper mill B as well as surface water samples collected downstream of Paper mill B effluent discharge induced DNA damage. The results confirmed that genotoxic contaminants were present only in wastewaters from Paper mill B that uses recycled fibres for paper production, and that the combined aerobic and anaerobic wastewater treatment procedure efficiently reduced contaminants that are bacterial mutagens, but not those that induce DNA damage in HepG2 cells. This study highlights that in addition to chemical analyses bioassays are needed for a comprehensive toxicological evaluation of

  17. Active Low Intrusion Hybrid Monitor for Wireless Sensor Networks

    PubMed Central

    Navia, Marlon; Campelo, Jose C.; Bonastre, Alberto; Ors, Rafael; Capella, Juan V.; Serrano, Juan J.

    2015-01-01

    Several systems have been proposed to monitor wireless sensor networks (WSN). These systems may be active (causing a high degree of intrusion) or passive (low observability inside the nodes). This paper presents the implementation of an active hybrid (hardware and software) monitor with low intrusion. It is based on the addition to the sensor node of a monitor node (hardware part) which, through a standard interface, is able to receive the monitoring information sent by a piece of software executed in the sensor node. The intrusion on time, code, and energy caused in the sensor nodes by the monitor is evaluated as a function of data size and the interface used. Then different interfaces, commonly available in sensor nodes, are evaluated: serial transmission (USART), serial peripheral interface (SPI), and parallel. The proposed hybrid monitor provides highly detailed information, barely disturbed by the measurement tool (interference), about the behavior of the WSN that may be used to evaluate many properties such as performance, dependability, security, etc. Monitor nodes are self-powered and may be removed after the monitoring campaign to be reused in other campaigns and/or WSNs. No other hardware-independent monitoring platforms with such low interference have been found in the literature. PMID:26393604

  18. Active Low Intrusion Hybrid Monitor for Wireless Sensor Networks.

    PubMed

    Navia, Marlon; Campelo, Jose C; Bonastre, Alberto; Ors, Rafael; Capella, Juan V; Serrano, Juan J

    2015-09-18

    Several systems have been proposed to monitor wireless sensor networks (WSN). These systems may be active (causing a high degree of intrusion) or passive (low observability inside the nodes). This paper presents the implementation of an active hybrid (hardware and software) monitor with low intrusion. It is based on the addition to the sensor node of a monitor node (hardware part) which, through a standard interface, is able to receive the monitoring information sent by a piece of software executed in the sensor node. The intrusion on time, code, and energy caused in the sensor nodes by the monitor is evaluated as a function of data size and the interface used. Then different interfaces, commonly available in sensor nodes, are evaluated: serial transmission (USART), serial peripheral interface (SPI), and parallel. The proposed hybrid monitor provides highly detailed information, barely disturbed by the measurement tool (interference), about the behavior of the WSN that may be used to evaluate many properties such as performance, dependability, security, etc. Monitor nodes are self-powered and may be removed after the monitoring campaign to be reused in other campaigns and/or WSNs. No other hardware-independent monitoring platforms with such low interference have been found in the literature.

  19. Photocardiography: a novel method for monitoring cardiac activity in fish.

    PubMed

    Yoshida, Masayuki; Hirano, Ruriko; Shima, Takao

    2009-05-01

    A non-invasive technique to monitor cardiac activity in small fish, such as goldfish, zebrafish, and medaka, is needed. In the present study, we developed photocardiography (PCG), a non-invasive optical method, to record cardiac activity in small fish. The method monitors changes in near-infrared light transmission through the heart using a phototransistor located outside the body. With this technique, heartbeats in fish of various sizes (14-218 mm) were stably recorded. PCG was applied to monitor the heartbeat during fear-related classical heart rate conditioning in goldfish wherein an electrical shock was used as an unconditioned stimulus. The heartbeats were continuously monitored, even when the beat coincided with the electrical shock, showing that PCG is robust even in an electrically noisy environment. This technique is particularly useful when monitoring the heartbeats of fish of small size or in the presence of ambient electrical noise, conditions in which the use of conventional electrocardiography (ECG) is difficult.

  20. Construction monitoring activities in the ESF starter tunnel

    SciTech Connect

    Pott, J.; Carlisle, S.

    1994-05-01

    In situ design verification activities am being conducted in the North Ramp Starter Tunnel of the Yucca Mountain Project Exploratory Studies Facility. These activities include: monitoring the peak particle velocities and evaluating the damage to the rock mass associated with construction blasting, assessing the rock mass quality surrounding the tunnel, monitoring the performance of the installed ground support, and monitoring the stability of the tunnel. In this paper, examples of the data that have been collected and preliminary conclusions from the data are presented.

  1. Bigelow Expandable Activity Module (BEAM) Monitoring System

    NASA Technical Reports Server (NTRS)

    Wells, Nathan

    2017-01-01

    What is Bigelow Expandable Activity Module (BEAM)? The Bigelow Expandable Activity Module (BEAM) is an expandable habitat technology demonstration on ISS; increase human-rated inflatable structure Technology Readiness Level (TRL) to level 9. NASA managed ISS payload project in partnership with Bigelow Aerospace. Launched to ISS on Space X 8 (April 8th, 2016). Fully expanded on May 28th, 2016. Jeff Williams/Exp. 48 Commander first entered BEAM on June 5th, 2016.

  2. Predicting Activity Energy Expenditure Using the Actical[R] Activity Monitor

    ERIC Educational Resources Information Center

    Heil, Daniel P.

    2006-01-01

    This study developed algorithms for predicting activity energy expenditure (AEE) in children (n = 24) and adults (n = 24) from the Actical[R] activity monitor. Each participant performed 10 activities (supine resting, three sitting, three house cleaning, and three locomotion) while wearing monitors on the ankle, hip, and wrist; AEE was computed…

  3. Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine

    PubMed Central

    Dervieux, T; Médard, Y; Baudouin, V; Maisin, A; Zhang, D; Broly, F; Loirat, C; Jacqz-Aigrain, E

    1999-01-01

    Aims Azathioprine is a prodrug commonly used in combination therapy to prevent allograft rejection after renal transplantation. After conversion to 6-mercaptopurine, the drug is metabolized into 6-thioguanine nucleotides (6-TGN) and catabolized by thiopurine methyltransferase (TPMT), an enzyme under monogenic control. The aim of this study was to evaluate the inter- and intraindividual variability of red blood cell thiopurine methyltransferase and 6-TGN concentrations and their relationship to the clinical effects of azathioprine in paediatric patients. Methods In the present study, the interand intraindividual variations in red blood cell TPMT activity and 6-TGN concentrations and their relationship to the actions of azathioprine were evaluated during the first year after renal transplantation in 22 paediatric patients. Results 6-TGN concentration reached steady-state values after 6 months and correlated negatively with TPMT activity (P=0.004). Initial TPMT activity (median: 20.8 nmol h−1 ml−1, range 7.8–34.6) and 6-TGN concentration at steady-state (median: 80 pmol 8×108–1 cells, range not detected to 366) were not related to the occurrence of rejection episodes during the period of the study. In contrast, TPMT activity and the percentage difference in TPMT activity from the day of transplantation determined at month 1 were higher in the patients with rejection episodes by comparison with those that did not reject during the first 3 months or the first year following transplantation (P<0.005). Conclusions We report a relationship between TPMT activity and occurrence of rejection in paediatric kidney transplant patients undergoing azathioprine therapy. These data suggest a link between high red blood cell TPMT activity and poor clinical outcome probably caused by rapid azathioprine catabolism. PMID:10594482

  4. Fabric-based integrated energy devices for wearable activity monitors.

    PubMed

    Jung, Sungmook; Lee, Jongsu; Hyeon, Taeghwan; Lee, Minbaek; Kim, Dae-Hyeong

    2014-09-01

    A wearable fabric-based integrated power-supply system that generates energy triboelectrically using human activity and stores the generated energy in an integrated supercapacitor is developed. This system can be utilized as either a self-powered activity monitor or as a power supply for external wearable sensors. These demonstrations give new insights for the research of wearable electronics.

  5. An overview of existing raptor contaminant monitoring activities in Europe.

    PubMed

    Gómez-Ramírez, P; Shore, R F; van den Brink, N W; van Hattum, B; Bustnes, J O; Duke, G; Fritsch, C; García-Fernández, A J; Helander, B O; Jaspers, V; Krone, O; Martínez-López, E; Mateo, R; Movalli, P; Sonne, C

    2014-06-01

    Biomonitoring using raptors as sentinels can provide early warning of the potential impacts of contaminants on humans and the environment and also a means of tracking the success of associated mitigation measures. Examples include detection of heavy metal-induced immune system impairment, PCB-induced altered reproductive impacts, and toxicity associated with lead in shot game. Authorisation of such releases and implementation of mitigation is now increasingly delivered through EU-wide directives but there is little established pan-European monitoring to quantify outcomes. We investigated the potential for EU-wide coordinated contaminant monitoring using raptors as sentinels. We did this using a questionnaire to ascertain the current scale of national activity across 44 European countries. According to this survey, there have been 52 different contaminant monitoring schemes with raptors over the last 50years. There were active schemes in 15 (predominantly western European) countries and 23 schemes have been running for >20years; most monitoring was conducted for >5years. Legacy persistent organic compounds (specifically organochlorine insecticides and PCBs), and metals/metalloids were monitored in most of the 15 countries. Fungicides, flame retardants and anticoagulant rodenticides were also relatively frequently monitored (each in at least 6 countries). Common buzzard (Buteo buteo), common kestrel (Falco tinnunculus), golden eagle (Aquila chrysaetos), white-tailed sea eagle (Haliaeetus albicilla), peregrine falcon (Falco peregrinus), tawny owl (Strix aluco) and barn owl (Tyto alba) were most commonly monitored (each in 6-10 countries). Feathers and eggs were most widely analysed although many schemes also analysed body tissues. Our study reveals an existing capability across multiple European countries for contaminant monitoring using raptors. However, coordination between existing schemes and expansion of monitoring into Eastern Europe is needed. This would enable

  6. Active Sites Environmental Monitoring Program: Mid-FY 1991 report

    SciTech Connect

    Ashwood, T.L.; Wickliff, D.S.; Morrissey, C.M.

    1991-10-01

    This report summarizes the activities of the Active Sites Environmental Monitoring Program (ASEMP) from October 1990 through March 1991. The ASEMP was established in 1989 by Solid Waste Operations and the Environmental Sciences Division to provide early detection and performance monitoring at active low-level radioactive waste (LLW) disposal sites in Solid Waste Storage Area (SWSA) 6 and transuranic (TRU) waste storage sites in SWSA 5 as required by chapters II and III of US Department of Energy Order 5820.2A. Monitoring results continue to demonstrate the no LLW is being leached from the storage vaults on the tumulus pads. Loading of vaults on Tumulus II began during this reporting period and 115 vaults had been loaded by the end of March 1991.

  7. 45 CFR 1610.8 - Program integrity of recipient.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... restricted activities. A recipient will be found to have objective integrity and independence from such an... no transfer of LSC funds, and LSC funds do not subsidize restricted activities; and (3) The recipient... LSC funds from other funds is not sufficient. Whether sufficient physical and financial...

  8. EarthScope Content Module for IRIS Active Earth Monitor

    NASA Astrophysics Data System (ADS)

    McQuillan, P. J.; Welti, R.; Johnson, J. A.; Shiffman, C. R.; Olds, S. E.

    2012-12-01

    The Active Earth Monitor (AEM) is an interactive computer-based display for university lobbies, museums, visitor centers, schools and libraries. AEM runs in a standard Internet web browser in full screen mode. The display consists of a customizable set of content pages about plate tectonics, earthquakes, volcanoes and tsunamis. Low-cost and simple-to-implement, the Active Earth Monitor provides a way to engage audiences with earth science information without spending resources on a large exhibit. The EarthScope Active Earth Monitor content set highlights the connections between the landscape and the research and monitoring being conducted by EarthScope in partnership with regional monitoring networks. Modules consist of chapters that focus on What is EarthScope?, EarthScope Observatories, and EarthScope Research Results. Content topics are easily explored using a web page button type navigation interface via a touch screen or mouse. A formative evaluation of general public users informed the interface design. Chapters in the modules start with a general overview and proceed to detailed specifics. Each chapter utilizes at least one set of live or near real-time research data (often more than one). This exposes the general public to active ongoing research that is engaging, relevant to the individual user, and explained in easy to understand terms. All live content is updated each time a user accesses the individual page displaying the live data. Leading questions are presented allowing the user to examine the content before accessing the answer via pop-up box. Diagrams and charts of research data have explanatory keys that allow users to self explore all content. Content pages can be created and inserted in the Active Earth Monitor by utilizing the simple HTML/CSS coding.;

  9. 20 CFR 641.881 - What are the SCSEP recipient's responsibilities relating to awards to sub-recipients?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... activities, including the performance of SCSEP activities by sub-recipients, and ensuring that sub-recipients... receive grants to provide services in an area where a substantial population of individuals with barriers... minority individuals, Indian individuals, individuals with greatest economic need, and...

  10. 20 CFR 641.881 - What are the SCSEP recipient's responsibilities relating to awards to sub-recipients?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... activities, including the performance of SCSEP activities by sub-recipients, and ensuring that sub-recipients... receive grants to provide services in an area where a substantial population of individuals with barriers... minority individuals, Indian individuals, individuals with greatest economic need, and...

  11. Influence of Activity Monitor Location and Bout Duration on Free-Living Physical Activity

    ERIC Educational Resources Information Center

    Heil, Daniel P.; Bennett, Gary G.; Bond, Kathleen S.; Webster, Michael D.; Wolin, Kathleen Y.

    2009-01-01

    The purpose of this study was to evaluate the influence of the location (ankle, hip, wrist) where an activity monitor (AM) is worn and of the minimum bout duration (BD) on physical activity (PA) variables during free-living monitoring. Study 1 participants wore AMs at three locations for 1 day while wearing the Intelligent Device for Energy…

  12. Progressive Multifocal Leukoencephalopathy in Transplant Recipients

    PubMed Central

    Mateen, Farrah J.; Muralidharan, RajaNandini; Carone, Marco; van de Beek, Diederik; Harrison, Daniel M.; Aksamit, Allen J.; Gould, Mary S.; Clifford, David B.; Nath, Avindra

    2016-01-01

    Objective Transplant recipients are at risk of developing progressive multifocal leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte destruction by JC virus. Methods Reports of PML following transplantation were found using PubMed Entrez (1958–July 2010). A multicenter, retrospective cohort study also identified all cases of PML among transplant recipients diagnosed at Mayo Clinic, Johns Hopkins University, Washington University, and Amsterdam Academic Medical Center. At 1 institution, the incidence of posttransplantation PML was calculated. Results A total of 69 cases (44 solid organ, 25 bone marrow) of posttransplantation PML were found including 15 from the 4 medical centers and another 54 from the literature. The median time to development of first symptoms of PML following transplantation was longer in solid organ vs bone marrow recipients (27 vs 11 months, p = 0.0005, range of <1 to >240). Median survival following symptom onset was 6.4 months in solid organ vs 19.5 months in bone marrow recipients (p = 0.068). Case fatality was 84% (95% confidence interval [CI], 70.3–92.4%) and survival beyond 1 year was 55.7% (95% CI, 41.2–67.2%). The incidence of PML among heart and/or lung transplant recipients at 1 institution was 1.24 per 1,000 posttransplantation person-years (95% CI, 0.25–3.61). No clear association was found with any 1 immunosuppressant agent. No treatment provided demonstrable therapeutic benefit. Interpretation The risk of PML exists throughout the posttransplantation period. Bone marrow recipients survive longer than solid organ recipients but may have a lower median time to first symptoms of PML. Posttransplantation PML has a higher case fatality and may have a higher incidence than reported in human immunodeficiency virus (HIV) patients on highly-active antiretroviral therapy (HAART) or multiple sclerosis patients treated with natalizumab. PMID:21823157

  13. 21 CFR 884.2730 - Home uterine activity monitor.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Home uterine activity monitor. 884.2730 Section 884.2730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... the clinic. The HUAM system comprises a tocotransducer, an at-home recorder, a modem, and a...

  14. 21 CFR 884.2730 - Home uterine activity monitor.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Home uterine activity monitor. 884.2730 Section 884.2730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... the clinic. The HUAM system comprises a tocotransducer, an at-home recorder, a modem, and a...

  15. Monitoring cell concentration and activity by multiple excitation fluorometry.

    PubMed

    Li, J K; Asali, E C; Humphrey, A E; Horvath, J J

    1991-01-01

    Four key cellular metabolic fluorophores--tryptophan, pyridoxine, NAD(P)H, and riboflavin--were monitored on-line by a multiple excitation fluorometric system (MEFS) and a modified SLM 8000C scanning spectrofluorometer in three model yeast fermentation systems--bakers' yeast growing on glucose, Candida utilis growing on ethanol, and Saccharomyces cerevisiae RTY110/pRB58 growing on glucose. The measured fluorescence signals were compared with cell concentration, protein concentration, and cellular activity. The results indicate that the behavior and fluorescence intensity of various fluorophores differ in the various fermentation systems. Tryptophan fluorescence is the best signal for the monitoring of cell concentration in bakers' yeast and C. utilis fermentations. Pyridoxine fluoresce is the best signal for the monitoring of cell concentration in the S. cerevisiae RTY110/pRB58 fermentation. In bakers' yeast fermentations the pyridoxine fluorescence signal can be used to monitor cellular activity. The NAD(P)H fluorescence signal is a good indicator of cellular activity in the C. utilis fermentation. For this fermentation NAD(P)H fluorescence can be used to control ethanol feeding in a fed-batch process.

  16. Limited activity monitoring in toddlers with autism spectrum disorder.

    PubMed

    Shic, Frederick; Bradshaw, Jessica; Klin, Ami; Scassellati, Brian; Chawarska, Katarzyna

    2011-03-22

    This study used eye-tracking to examine how 20-month-old toddlers with autism spectrum disorder (ASD) (n=28), typical development (TD) (n=34), and non-autistic developmental delays (DD) (n=16) monitored the activities occurring in a context of an adult-child play interaction. Toddlers with ASD, in comparison to control groups, showed less attention to the activities of others and focused more on background objects (e.g., toys). In addition, while all groups spent the same time overall looking at people, toddlers with ASD looked less at people's heads and more at their bodies. In ASD, these patterns were associated with cognitive deficits and greater autism severity. These results suggest that the monitoring of the social activities of others is disrupted early in the developmental progression of autism, limiting future avenues for observational learning.

  17. Monitoring and evaluating school nutrition and physical activity policies.

    PubMed

    Taylor, Jennifer P; McKenna, Mary L; Butler, Gregory P

    2010-01-01

    Given the increase in the number of Canadian jurisdictions with school nutrition and/or physical activity policies, there is a need to assess the effectiveness of such policies. The objectives of this paper are to 1) provide an overview of key issues in monitoring and evaluating school nutrition and physical activity policies in Canada and 2) identify areas for further research needed to strengthen the evidence base and inform the development of effective approaches to monitoring and evaluation. Evaluation indicators, data sources and existing tools for evaluating nutrition and physical activity are reviewed. This paper has underscored the importance of identifying common indicators and approaches, using a comprehensive approach based on the WHO framework and ensuring that research capacity and funding is in place to facilitate high-quality evaluation efforts in the future.

  18. 28 CFR 42.722 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Recipient assessment of age distinctions... EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Nondiscrimination on the Basis of Age in Federally Assisted Programs or Activities; Implementation of the Age Discrimination Act of 1975 Duties of Recipients §...

  19. 28 CFR 42.722 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Recipient assessment of age distinctions... EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Nondiscrimination on the Basis of Age in Federally Assisted Programs or Activities; Implementation of the Age Discrimination Act of 1975 Duties of Recipients §...

  20. 28 CFR 42.722 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Recipient assessment of age distinctions... EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Nondiscrimination on the Basis of Age in Federally Assisted Programs or Activities; Implementation of the Age Discrimination Act of 1975 Duties of Recipients §...

  1. 28 CFR 42.722 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Recipient assessment of age distinctions... EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Nondiscrimination on the Basis of Age in Federally Assisted Programs or Activities; Implementation of the Age Discrimination Act of 1975 Duties of Recipients §...

  2. 28 CFR 42.722 - Recipient assessment of age distinctions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Recipient assessment of age distinctions... EMPLOYMENT OPPORTUNITY; POLICIES AND PROCEDURES Nondiscrimination on the Basis of Age in Federally Assisted Programs or Activities; Implementation of the Age Discrimination Act of 1975 Duties of Recipients §...

  3. 45 CFR 1612.11 - Recipient policies and procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Recipient policies and procedures. 1612.11 Section 1612.11 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION RESTRICTIONS ON LOBBYING AND CERTAIN OTHER ACTIVITIES § 1612.11 Recipient policies and procedures....

  4. The value to the anaesthetist of monitoring cerebral activity.

    PubMed

    Langford, R M; Thomsen, C E

    1994-03-01

    The administration rate of general anaesthetic drugs is at present guided by clinical experience, and indirect indicators such as haemodynamic parameters. In the presence of muscle relaxants most of the clinical signs of inadequate anaesthesia are lost and accidental awareness may occur. A number of monitoring modalities, primarily based on analysis of the electroencephalogram (EEG), have been proposed for measurement of the anaesthetic depth. Moreover intraoperative cerebral monitoring may also provide the anaesthetist with early warning of cerebral ischaemia, or information on specific neurological pathways. To facilitate this, it is essential to combine analysis of the spontaneous EEG with recording of evoked potentials, to assess both cortical and subcortical activity/events. None of the reviewed methods, however promising, can alone meet all of the requirements for intraoperative monitoring of cerebral function. We suggest that the future direction should be to integrate several modalities in a single device, to provide valuable new information, upon which to base clinical management decisions.

  5. On-line Monitoring and Active Control for Transformer Noise

    NASA Astrophysics Data System (ADS)

    Liang, Jiabi; Zhao, Tong; Tian, Chun; Wang, Xia; He, Zhenhua; Duan, Lunfeng

    This paper introduces the system for on-line monitoring and active noise control towards the transformer noise based on LabVIEW and the hardware equipment including the hardware and software. For the hardware part, it is mainly focused on the composition and the role of hardware devices, as well as the mounting location in the active noise control experiment. And the software part introduces the software flow chats, the measurement and analysis module for the sound pressure level including A, B, C weighting methods, the 1/n octave spectrum and the power spectrum, active noise control module and noise data access module.

  6. 40 CFR 7.85 - Recipients.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Recipients. 7.85 Section 7.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL ASSISTANCE FROM THE ENVIRONMENTAL PROTECTION AGENCY Requirements for Applicants...

  7. 40 CFR 7.85 - Recipients.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Recipients. 7.85 Section 7.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL ASSISTANCE FROM THE ENVIRONMENTAL PROTECTION AGENCY Requirements for Applicants...

  8. 40 CFR 7.85 - Recipients.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Recipients. 7.85 Section 7.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL NONDISCRIMINATION IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL ASSISTANCE FROM THE ENVIRONMENTAL PROTECTION AGENCY Requirements for Applicants...

  9. Active Sites Environmental Monitoring Program: Program plan. Revision 1

    SciTech Connect

    Ashwood, T.L.; Wickliff, D.S.; Morrissey, C.M.

    1992-02-01

    The Active Sites Environmental Monitoring Program (ASEMP), initiated in 1989, provides early detection and performance monitoring of transuranic (TRU) waste and active low-level waste (LLW) facilities at Oak Ridge National Laboratory (ORNL) in accordance with US Department of Energy (DOE) Order 5820.2A. Active LLW facilities in Solid Waste Storage Area (SWSA) 6 include Tumulus I and Tumulus II, the Interim Waste Management Facility (IWMF), LLW silos, high-range wells, asbestos silos, and fissile wells. The tumulus pads and IWMF are aboveground, high-strength concrete pads on which concrete vaults containing metal boxes of LLW are placed; the void space between the boxes and vaults is filled with grout. Eventually, these pads and vaults will be covered by an engineered multilayered cap. All other LLW facilities in SWSA 6 are below ground. In addition, this plan includes monitoring of the Hillcut Disposal Test Facility (HDTF) in SWSA 6, even though this facility was completed prior to the data of the DOE order. In SWSA 5 North, the TRU facilities include below-grade engineered caves, high-range wells, and unlined trenches. All samples from SWSA 6 are screened for alpha and beta activity, counted for gamma-emitting isotopes, and analyzed for tritium. In addition to these analytes, samples from SWSA 5 North are analyzed for specific transuranic elements.

  10. Sentinel-1 Contribution to Monitoring Maritime Activity in the Arctic

    NASA Astrophysics Data System (ADS)

    Santamaria, Carlos; Greidanus, Harm; Fournier, Melanie; Eriksen, Torkild; Vespe, Michele; Alvarez, Marlene; Arguedas, Virginia Fernandez; Delaney, Conor; Argentieri, Pietro

    2016-08-01

    This paper presents results on the use of Sentinel-1 combined with satellite AIS to monitor maritime activity in the Arctic. Such activities are expected to increase, even if not uniformly across the Arctic, as the ice cover in the region retreats due to changes in climate. The objectives of monitoring efforts in the region can vary from country to country, but are generally related to increasing awareness on non- cooperative, small and cruise ships, fisheries, safety at sea, and Search and Rescue. A ship monitoring study has been conducted, involving more than 2,000 Sentinel-1 images acquired during one year in the central Arctic, where the ship densities are high. The main challenges to SAR-based monitoring in this area are described, solutions for some of them are proposed, and analyses of the results are shown. With the high detection thresholds needed to prevent false alarms from sea ice, 16% of the ships detected overall in the Sentinel-1 images have not been correlated to AIS- transmitting ships, and 48% of the AIS-transmitting ships are not correlated to ships detected in the images.

  11. Toward Active Monitoring of Piping Using Ultrasonic Guided Waves

    SciTech Connect

    Park, Joon-Soo; Kim, Young H.; Song, Sung-Jin; Kim, Jae-Hee; Eom, Heung-Seop; Im, Kwang-Hee

    2004-02-26

    Piping in nuclear power plants is exposed to severe environmental conditions so that it is very susceptible to failure caused by the growth of defects. Thus, it is necessary to have thorough inspection of piping in order to detect defects before failure. Unfortunately, however, inspection of piping in nuclear power plants is not easy in practice because of its long length as well as the radioactive environment. To take care of this difficulty, a research endeavor to develop techniques to monitor piping in nuclear power plants continuously and actively using ultrasonic guided wave is currently undertaken. This paper reports initial results of our endeavor including design of an ultrasonic array system for active monitoring of piping.

  12. Energy monitoring system based on human activity in the workplace

    NASA Astrophysics Data System (ADS)

    Mustafa, Nur Hanim; Husain, Mohd Nor; Aziz, Mohamad Zoinol Abidin Abdul; Othman, Mohd Azlishah; Malek, Fareq

    2015-05-01

    Human behaviors always related to day routine activities in a smart house directly give the significant factor to manage energy usage in human life. An Addition that, the factor will contribute to the best efficiency of the system. This paper will focus on the monitoring efficiency based on duration time in office hours around 8am until 5pm which depend on human behavior at working place. Besides that, the correlation coefficient method is used to show the relation between energy consumption and energy saving based on the total hours of time energy spent. In future, the percentages of energy monitoring system usage will be increase to manage energy saving based on human behaviors. This scenario will help to see the human activity in the workplace in order to get the energy saving and support world green environment.

  13. Method for monitoring stack gases for uranium activity

    DOEpatents

    Beverly, Claude R.; Ernstberger, Harold G.

    1988-01-01

    A method for monitoring the stack gases of a purge cascade of a gaseous diffusion plant for uranium activity. A sample stream is taken from the stack gases and contacted with a volume of moisture-laden air for converting trace levels of uranium hexafluoride, if any, in the stack gases into particulate uranyl fluoride. A continuous strip of filter paper from a supply roll is passed through this sampling stream to intercept and gather any uranyl fluoride in the sampling stream. This filter paper is then passed by an alpha scintillation counting device where any radioactivity on the filter paper is sensed so as to provide a continuous monitoring of the gas stream for activity indicative of the uranium content in the stack gases.

  14. Method for monitoring stack gases for uranium activity

    DOEpatents

    Beverly, C.R.; Ernstberger, E.G.

    1985-07-03

    A method for monitoring the stack gases of a purge cascade of gaseous diffusion plant for uranium activity. A sample stream is taken from the stack gases and contacted with a volume of moisture-laden air for converting trace levels of uranium hexafluoride, if any, in the stack gases into particulate uranyl fluoride. A continuous strip of filter paper from a supply roll is passed through this sampling stream to intercept and gather any uranyl fluoride in the sampling stream. This filter paper is then passed by an alpha scintillation counting device where any radioactivity on the filter paper is sensed so as to provide a continuous monitoring of the gas stream for activity indicative of the uranium content in the stack gases. 1 fig.

  15. Active Geophysical Monitoring in Oil and Gas Industry

    NASA Astrophysics Data System (ADS)

    Bakulin, A.; Calvert, R.

    2005-12-01

    Effective reservoir management is a Holy Grail of the oil and gas industry. Quest for new technologies is never ending but most often they increase effectiveness and decrease the costs. None of the newcomers proved to be a silver bullet in such a key metric of the industry as average oil recovery factor. This factor is still around 30 %, meaning that 70 % of hydrocarbon reserves are left in the ground in places where we already have expensive infrastructure (platforms, wells) to extract them. Main reason for this inefficiency is our inability to address realistic reservoir complexity. Most of the time we fail to properly characterize our reservoirs before production. As a matter of fact, one of the most important parameters -- permeability -- can not be mapped from remote geophysical methods. Therefore we always start production blind even though reservoir state before production is the simplest one. Once first oil is produced, we greatly complicate the things and quickly become unable to estimate the state and condition of the reservoir (fluid, pressures, faults etc) or oilfield hardware (wells, platforms, pumps) to make a sound next decision in the chain of reservoir management. Our modeling capabilities are such that if we know true state of the things - we can make incredibly accurate predictions and make extremely efficient decisions. Thus the bottleneck is our inability to properly describe the state of the reservoirs in real time. Industry is starting to recognize active monitoring as an answer to this critical issue. We will highlight industry strides in active geophysical monitoring from well to reservoir scale. It is worth noting that when one says ``monitoring" production technologists think of measuring pressures at the wellhead or at the pump, reservoir engineers think of measuring extracted volumes and pressures, while geophysicist may think of change in elastic properties. We prefer to think of monitoring as to measuring those parameters of the

  16. Integrated active sensor system for real time vibration monitoring.

    PubMed

    Liang, Qijie; Yan, Xiaoqin; Liao, Xinqin; Cao, Shiyao; Lu, Shengnan; Zheng, Xin; Zhang, Yue

    2015-11-05

    We report a self-powered, lightweight and cost-effective active sensor system for vibration monitoring with multiplexed operation based on contact electrification between sensor and detected objects. The as-fabricated sensor matrix is capable of monitoring and mapping the vibration state of large amounts of units. The monitoring contents include: on-off state, vibration frequency and vibration amplitude of each unit. The active sensor system delivers a detection range of 0-60 Hz, high accuracy (relative error below 0.42%), long-term stability (10000 cycles). On the time dimension, the sensor can provide the vibration process memory by recording the outputs of the sensor system in an extend period of time. Besides, the developed sensor system can realize detection under contact mode and non-contact mode. Its high performance is not sensitive to the shape or the conductivity of the detected object. With these features, the active sensor system has great potential in automatic control, remote operation, surveillance and security systems.

  17. Integrated active sensor system for real time vibration monitoring

    PubMed Central

    Liang, Qijie; Yan, Xiaoqin; Liao, Xinqin; Cao, Shiyao; Lu, Shengnan; Zheng, Xin; Zhang, Yue

    2015-01-01

    We report a self-powered, lightweight and cost-effective active sensor system for vibration monitoring with multiplexed operation based on contact electrification between sensor and detected objects. The as-fabricated sensor matrix is capable of monitoring and mapping the vibration state of large amounts of units. The monitoring contents include: on-off state, vibration frequency and vibration amplitude of each unit. The active sensor system delivers a detection range of 0–60 Hz, high accuracy (relative error below 0.42%), long-term stability (10000 cycles). On the time dimension, the sensor can provide the vibration process memory by recording the outputs of the sensor system in an extend period of time. Besides, the developed sensor system can realize detection under contact mode and non-contact mode. Its high performance is not sensitive to the shape or the conductivity of the detected object. With these features, the active sensor system has great potential in automatic control, remote operation, surveillance and security systems. PMID:26538293

  18. Human psychophysiological activity monitoring methods using fiber optic sensors

    NASA Astrophysics Data System (ADS)

    Zyczkowski, M.; Uzieblo-Zyczkowska, B.

    2010-10-01

    The paper presents the concept of fiber optic sensor system for human psycho-physical activity detection. A fiber optic sensor that utilizes optical phase interferometry or intensity in modalmetric to monitor a patient's vital signs such as respiration cardiac activity, blood pressure and body's physical movements. The sensor, which is non-invasive, comprises an optical fiber interferometer that includes an optical fiber proximately situated to the patient so that time varying acusto-mechanical signals from the patient are coupled into the optical fiber. The system can be implemented in embodiments ranging form a low cost in-home to a high end product for in hospital use.

  19. Aspergillus Infections in Transplant Recipients

    PubMed Central

    Singh, Nina; Paterson, David L.

    2005-01-01

    Aspergillus infections are occurring with an increasing frequency in transplant recipients. Notable changes in the epidemiologic characteristics of this infection have occurred; these include a change in risk factors and later onset of infection. Management of invasive aspergillosis continues to be challenging, and the mortality rate, despite the use of newer antifungal agents, remains unacceptably high. Performing molecular studies to discern new targets for antifungal activity, identifying signaling pathways that may be amenable to immunologic interventions, assessing combination regimens of antifungal agents or combining antifungal agents with modulation of the host defense mechanisms, and devising diagnostic assays that can rapidly and reliably diagnose infections represent areas for future investigations that may lead to further improvement in outcomes. PMID:15653818

  20. In-vessel activation monitors in JET: Progress in modeling

    SciTech Connect

    Bonheure, Georges; Lengar, I.; Syme, B.; Popovichev, S.; Arnold, Dirk; Laubenstein, Matthias

    2008-10-15

    Activation studies were performed in JET with new in-vessel activation monitors. Though primarily dedicated to R and D in the challenging issue of lost {alpha} diagnostics for ITER, which is being addressed at JET with several techniques, these monitors provide for both neutron and charged particle fluences. A set of samples with different orientation with respect to the magnetic field is transported inside the torus by means of a manipulator arm (in contrast with the conventional JET activation system with pneumatic transport system). In this case, radionuclides with longer half-life were selected and ultralow background gamma-ray measurements were needed. The irradiation was closer to the plasma and this potentially reduces the neutron scattering problem. This approach could also be of interest for ITER, where the calibration methods have yet to be developed. The MCNP neutron transport model for JET was modified to include the activation probe and so provide calculations to help assess the new data. The neutron induced activity on the samples are well reproduced by the calculations.

  1. Advanced Performance Modeling with Combined Passive and Active Monitoring

    SciTech Connect

    Dovrolis, Constantine; Sim, Alex

    2015-04-15

    To improve the efficiency of resource utilization and scheduling of scientific data transfers on high-speed networks, the "Advanced Performance Modeling with combined passive and active monitoring" (APM) project investigates and models a general-purpose, reusable and expandable network performance estimation framework. The predictive estimation model and the framework will be helpful in optimizing the performance and utilization of networks as well as sharing resources with predictable performance for scientific collaborations, especially in data intensive applications. Our prediction model utilizes historical network performance information from various network activity logs as well as live streaming measurements from network peering devices. Historical network performance information is used without putting extra load on the resources by active measurement collection. Performance measurements collected by active probing is used judiciously for improving the accuracy of predictions.

  2. Caregiver Confidence: Does It Predict Changes in Disability among Elderly Home Care Recipients?

    ERIC Educational Resources Information Center

    Li, Lydia W.; McLaughlin, Sara J.

    2012-01-01

    Purpose of the study: The primary aim of this investigation was to determine whether caregiver confidence in their care recipients' functional capabilities predicts changes in the performance of activities of daily living (ADL) among elderly home care recipients. A secondary aim was to explore how caregiver confidence and care recipient functional…

  3. Design considerations in an active medical product safety monitoring system.

    PubMed

    Gagne, Joshua J; Fireman, Bruce; Ryan, Patrick B; Maclure, Malcolm; Gerhard, Tobias; Toh, Sengwee; Rassen, Jeremy A; Nelson, Jennifer C; Schneeweiss, Sebastian

    2012-01-01

    Active medical product monitoring systems, such as the Sentinel System, will utilize electronic healthcare data captured during routine health care. Safety signals that arise from these data may be spurious because of chance or bias, particularly confounding bias, given the observational nature of the data. Applying appropriate monitoring designs can filter out many false-positive and false-negative associations from the outset. Designs can be classified by whether they produce estimates based on between-person or within-person comparisons. In deciding which approach is more suitable for a given monitoring scenario, stakeholders must consider the characteristics of the monitored product, characteristics of the health outcome of interest (HOI), and characteristics of the potential link between these. Specifically, three factors drive design decisions: (i) strength of within-person and between-person confounding; (ii) whether circumstances exist that may predispose to misclassification of exposure or misclassification of the timing of the HOI; and (iii) whether the exposure of interest is predominantly transient or sustained. Additional design considerations include whether to focus on new users, the availability of appropriate active comparators, the presence of an exposure time trend, and the measure of association of interest. When the key assumptions of self-controlled designs are fulfilled (i.e., lack of within-person, time-varying confounding; abrupt HOI onset; and transient exposure), within-person comparisons are preferred because they inherently avoid confounding by fixed factors. The cohort approach generally is preferred in other situations and particularly when timing of exposure or outcome is uncertain because cohort approaches are less vulnerable to biases resulting from misclassification.

  4. Career Maturity of Welfare Recipients.

    ERIC Educational Resources Information Center

    Beckman, Carol M.

    To investigate the career maturity of welfare recipients, this thesis examines six independent variables: (1) race; (2) sex; (3) age; (4) level of formal education; (5) general intelligence; and (6) locus of control. Scales taken from the Career Maturity Inventory served as the dependent variables. The sample consisted of 83 welfare recipients who…

  5. FRET-based optical assay for monitoring riboswitch activation.

    PubMed

    Harbaugh, Svetlana; Kelley-Loughnane, Nancy; Davidson, Molly; Narayanan, Latha; Trott, Sandra; Chushak, Yaroslav G; Stone, Morley O

    2009-05-11

    Riboswitches are regulatory RNAs located in the 5'-untranslated region of mRNA sequences that recognize and bind to small molecules and regulate the expression of downstream genes. Creation of synthetic riboswitches to novel ligands depends on the ability to monitor riboswitch activation in the presence of analyte. In our work, we have coupled a synthetic riboswitch to an optical reporter assay based on fluorescence resonance energy transfer (FRET) between two genetically encoded fluorescent proteins. The theophylline-sensitive riboswitch was placed upstream of the Tobacco Etch Virus (TEV) protease coding sequence. Our FRET construct was composed of eGFP and a nonfluorescent yellow fluorescent protein mutant called REACh (for resonance energy-accepting chromoprotein) connected with a peptide linker containing a TEV protease cleavage site. Addition of theophylline to the E. coli cells activates the riboswitch and initiates the translation of mRNA. Synthesized protease cleaves the linker in the FRET-based fusion protein causing a change in the fluorescence signal. By this method, we observed an 11-fold increase in cellular extract fluorescence in the presence of theophylline. The advantage of using an eGFP-REACh pair is the elimination of acceptor fluorescence. This leads to an improved detection of FRET via better signal-to-noise ratio, allowing us to monitor riboswitch activation in a wide range of analyte concentrations from 0.01 to 2.5 mM.

  6. Monitoring Heparin Therapy with the Activated Partial Thromboplastin Time

    PubMed Central

    Stuart, R. K.; Michel, A.

    1971-01-01

    Difficulties associated with the whole blood clotting time (W.B.C.T.) as a method of monitoring heparin therapy have led to the investigation of the activated partial thromboplastin time (A.P.T.T.) as an alternative. The conclusion is reached that the latter procedure possesses several advantages. Using the method described and a citrate-preserved blood sample collected just prior to the administration of the next serial dose of heparin, the suggested therapeutic duration of the A.P.T.T. is 70 seconds or twice the mean control value. A practical range for this method is 60 to 70 seconds. PMID:5557913

  7. Monitoring rice farming activities in the Mekong Delta region

    NASA Astrophysics Data System (ADS)

    Nguyen, S. T.; Chen, C. F.; Chen, C. R.; Chiang, S. H.; Chang, L. Y.; Khin, L. V.

    2015-12-01

    Half of the world's population depends on rice for survival. Rice agriculture thus plays an important role in the developing world's economy. Vietnam is one of the largest rice producers and suppliers on earth and more than 80% of the exported rice was produced from the Mekong Delta region, which is situated in the southwestern Vietnam and encompasses approximately 40,000 km2. Changes in climate conditions could likely trigger the increase of insect populations and rice diseases, causing the potential loss of rice yields. Monitoring rice-farming activities through crop phenology detection can provide policymakers with timely strategies to mitigate possible impacts on the potential yield as well as rice grain exports to ensure food security for the region. The main objective of this study is to develop a logistic-based algorithm to investigate rice sowing and harvesting activities from the multi-temporal Moderate Resolution Imaging Spectroradiometer (MODIS)-Landsat fusion data. We processed the data for two main cropping seasons (i.e., winter-spring and summer-autumn seasons) through a three-step procedure: (1) MODIS-Landsat data fusion, (2) construction of the time-series enhanced vegetation index 2 (EVI2) data, (3) rice crop phenology detection. The EVI2 data derived from the fusion results between MODIS and Landsat data were compared with that of Landsat data indicated close correlation between the two datasets (R2 = 0.93). The time-series EVI2 data were processed using the double logistic method to detect the progress of sowing and harvesting activities in the region. The comparisons between the estimated sowing and harvesting dates and the field survey data revealed the root mean squared error (RMSE) values of 8.4 and 5.5 days for the winter-spring crop and 9.4 and 12.8 days for the summer-autumn crop, respectively. This study demonstrates the effectiveness of the double logistic-based algorithm for rice crop monitoring from temporal MODIS-Landsat fusion data

  8. Environmental Monitoring Networks Optimization Using Advanced Active Learning Algorithms

    NASA Astrophysics Data System (ADS)

    Kanevski, Mikhail; Volpi, Michele; Copa, Loris

    2010-05-01

    The problem of environmental monitoring networks optimization (MNO) belongs to one of the basic and fundamental tasks in spatio-temporal data collection, analysis, and modeling. There are several approaches to this problem, which can be considered as a design or redesign of monitoring network by applying some optimization criteria. The most developed and widespread methods are based on geostatistics (family of kriging models, conditional stochastic simulations). In geostatistics the variance is mainly used as an optimization criterion which has some advantages and drawbacks. In the present research we study an application of advanced techniques following from the statistical learning theory (SLT) - support vector machines (SVM) and the optimization of monitoring networks when dealing with a classification problem (data are discrete values/classes: hydrogeological units, soil types, pollution decision levels, etc.) is considered. SVM is a universal nonlinear modeling tool for classification problems in high dimensional spaces. The SVM solution is maximizing the decision boundary between classes and has a good generalization property for noisy data. The sparse solution of SVM is based on support vectors - data which contribute to the solution with nonzero weights. Fundamentally the MNO for classification problems can be considered as a task of selecting new measurement points which increase the quality of spatial classification and reduce the testing error (error on new independent measurements). In SLT this is a typical problem of active learning - a selection of the new unlabelled points which efficiently reduce the testing error. A classical approach (margin sampling) to active learning is to sample the points closest to the classification boundary. This solution is suboptimal when points (or generally the dataset) are redundant for the same class. In the present research we propose and study two new advanced methods of active learning adapted to the solution of

  9. Stress monitoring versus microseismic ruptures in an active deep mine

    NASA Astrophysics Data System (ADS)

    Tonnellier, Alice; Bouffier, Christian; Bigarré, Pascal; Nyström, Anders; Österberg, Anders; Fjellström, Peter

    2015-04-01

    monitoring data coming from the mine in quasi-real time and facilitates information exchanges and decision making for experts and stakeholders. On the basis of these data acquisition and sharing, preliminary analysis has been started to highlight whether stress variations and seismic sources behaviour might be directly bound with mine working evolution and could improve the knowledge on the equilibrium states inside the mine. Knowing such parameters indeed will be a potential solution to understand better the response of deep mining activities to the exploitation solicitations and to develop, if possible, methods to prevent from major hazards such as rock bursts and other ground failure phenomena.

  10. A process activity monitor for AOS/VS

    NASA Technical Reports Server (NTRS)

    Mckosky, R. A.; Lindley, S. W.; Chapman, J. S.

    1986-01-01

    With the ever increasing concern for computer security, users of computer systems are becoming more sensitive to unauthorized access. One of the initial security concerns for the Shuttle Management Information System was the problem of users leaving their workstations unattended while still connected to the system. This common habit was a concern for two reasons: it ties up resources unnecessarily and it opens the way for unauthorized access to the system. The Data General MV/10000 does not come equipped with an automatic time-out option on interactive peripherals. The purpose of this memorandum is to describe a system which monitors process activity on the system and disconnects those users who show no activity for some time quantum.

  11. Active sensors for health monitoring of aging aerospace structures

    SciTech Connect

    GIURGIUTIU,VICTOR; REDMOND,JAMES M.; ROACH,DENNIS P.; RACKOW,KIRK A.

    2000-03-08

    A project to develop non-intrusive active sensors that can be applied on existing aging aerospace structures for monitoring the onset and progress of structural damage (fatigue cracks and corrosion) is presented. The state of the art in active sensors structural health monitoring and damage detection is reviewed. Methods based on (a) elastic wave propagation and (b) electro-mechanical (NM) impedance technique are sighted and briefly discussed. The instrumentation of these specimens with piezoelectric active sensors is illustrated. The main detection strategies (E/M impedance for local area detection and wave propagation for wide area interrogation) are discussed. The signal processing and damage interpretation algorithms are tuned to the specific structural interrogation method used. In the high-frequency EIM impedance approach, pattern recognition methods are used to compare impedance signatures taken at various time intervals and to identify damage presence and progression from the change in these signatures. In the wave propagation approach, the acoustic-ultrasonic methods identifying additional reflection generated from the damage site and changes in transmission velocity and phase are used. Both approaches benefit from the use of artificial intelligence neural networks algorithms that can extract damage features based on a learning process. Design and fabrication of a set of structural specimens representative of aging aerospace structures is presented. Three built-up specimens, (pristine, with cracks, and with corrosion damage) are used. The specimen instrumentation with active sensors fabricated at the University of South Carolina is illustrated. Preliminary results obtained with the E/M impedance method on pristine and cracked specimens are presented.

  12. Active sensors for health monitoring of aging aerospace structures

    SciTech Connect

    GIURGIUTIU,VICTOR; REDMOND,JAMES M.; ROACH,DENNIS P.; RACKOW,KIRK A.

    2000-02-29

    A project to develop non-intrusive active sensors that can be applied on existing aging aerospace structures for monitoring the onset and progress of structural damage (fatigue cracks and corrosion) is presented. The state of the art in active sensors structural health monitoring and damage detection is reviewed. Methods based on (a) elastic wave propagation and (b) electro-mechanical (E/M) impedance technique are cited and briefly discussed. The instrumentation of these specimens with piezoelectric active sensors is illustrated. The main detection strategies (E/M impedance for local area detection and wave propagation for wide area interrogation) are discussed. The signal processing and damage interpretation algorithms are tuned to the specific structural interrogation method used. In the high-frequency E/M impedance approach, pattern recognition methods are used to compare impedance signatures taken at various time intervals and to identify damage presence and progression from the change in these signatures. In the wave propagation approach, the acousto-ultrasonic methods identifying additional reflection generated from the damage site and changes in transmission velocity and phase are used. Both approaches benefit from the use of artificial intelligence neural networks algorithms that can extract damage features based on a learning process. Design and fabrication of a set of structural specimens representative of aging aerospace structures is presented. Three built-up specimens (pristine, with cracks, and with corrosion damage) are used. The specimen instrumentation with active sensors fabricated at the University of South Carolina is illustrated. Preliminary results obtained with the E/M impedance method on pristine and cracked specimens are presented.

  13. Differential actigraphy for monitoring asymmetry in upper limb motor activities.

    PubMed

    Rabuffetti, M; Meriggi, P; Pagliari, C; Bartolomeo, P; Ferrarin, M

    2016-09-21

    Most applications of accelerometry-based actigraphy require a single sensor, properly located onto the body, to estimate, for example, the level of activity or the energy expenditure. Some approaches adopt a multi-sensor setup to improve those analyses or to classify different types of activity. The specific case of two symmetrically placed actigraphs allowing, by some kind of differential analysis, for the assessment of asymmetric motor behaviors, has been considered in relatively few studies. This article presents a novel method for differential actigraphy, which requires the synchronized measurements of two triaxial accelerometers (programmable eZ430-Chronos, Texas Instruments, USA) placed symmetrically on both wrists. The method involved the definition of a robust epoch-related activity index and its implementation on-board the adopted programmable platform. Finally, the activity recordings from both sensors allowed us to define a novel asymmetry index AR24 h ranging from  -100% (only the left arm moves) to  +100% (only the right arm moves) with null value marking a perfect symmetrical behavior. The accuracy of the AR24 h index was 1.3%. Round-the-clock monitoring on 31 healthy participants (20-79 years old, 10 left handed) provided for the AR24 h reference data (range  -5% to 21%) and a fairly good correlation to the clinical handedness index (r  =  0.66, p  <  0.001). A subset of 20 participants repeated the monitoring one week apart evidencing an excellent test-retest reliability (r  =  0.70, p  <  0.001). Such figures support future applications of the methodology for the study of pathologies involving motor asymmetries, such as in patients with motor hemisyndromes and, in general, for those subjects for whom a quantification of the asymmetry in daily motor performances is required to complement laboratory tests.

  14. Active Volcano Monitoring using a Space-based Hyperspectral Imager

    NASA Astrophysics Data System (ADS)

    Cipar, J. J.; Dunn, R.; Cooley, T.

    2010-12-01

    Active volcanoes occur on every continent, often in close proximity to heavily populated areas. While ground-based studies are essential for scientific research and disaster mitigation, remote sensing from space can provide rapid and continuous monitoring of active and potentially active volcanoes [Ramsey and Flynn, 2004]. In this paper, we report on hyperspectral measurements of Kilauea volcano, Hawaii. Hyperspectral images obtained by the US Air Force TacSat-3/ARTEMIS sensor [Lockwood et al, 2006] are used to obtain estimates of the surface temperatures for the volcano. ARTEMIS measures surface-reflected light in the visible, near-infrared, and short-wave infrared bands (VNIR-SWIR). The SWIR bands are known to be sensitive to thermal radiation [Green, 1996]. For example, images from the NASA Hyperion hyperspectral sensor have shown the extent of wildfires and active volcanoes [Young, 2009]. We employ the methodology described by Dennison et al, (2006) to obtain an estimate of the temperature of the active region of Kilauea. Both day and night-time images were used in the analysis. To improve the estimate, we aggregated neighboring pixels. The active rim of the lava lake is clearly discernable in the temperature image, with a measured temperature exceeding 1100o C. The temperature decreases markedly on the exterior of the summit crater. While a long-wave infrared (LWIR) sensor would be ideal for volcano monitoring, we have shown that the thermal state of an active volcano can be monitored using the SWIR channels of a reflective hyperspectral imager. References: Dennison, Philip E., Kraivut Charoensiri, Dar A. Roberts, Seth H. Peterson, and Robert O. Green (2006). Wildfire temperature and land cover modeling using hyperspectral data, Remote Sens. Environ., vol. 100, pp. 212-222. Green, R. O. (1996). Estimation of biomass fire temperature and areal extent from calibrated AVIRIS spectra, in Summaries of the 6th Annual JPL Airborne Earth Science Workshop, Pasadena, CA

  15. Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity

    SciTech Connect

    Lapidot, T.; Lubin, I.; Terenzi, A.; Faktorowich, Y.; Erlich, P.; Reisner, Y. )

    1990-06-01

    Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. Mixing experiments using different numbers of nude bone marrow cells with or without mature thymocytes (unagglutinated by peanut agglutinin) revealed that engraftment of allogeneic T-cell-depleted bone marrow is T-cell dependent. To ensure engraftment, a large inoculum of nude bone marrow must be supplemented with a trace number of donor T cells, whereas a small bone marrow dose from nude donors requires a much larger number of T cells for engraftment. Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by alloreactivity against residual host cells but may rather be generated by growth factors, the release of which may require specific interactions between T cells and stem cells or between T cells and bone marrow stroma cells.

  16. Indirect enzyme-linked immunosorbent assay for immunoglobulin G and four immunoassays for immunoglobulin M to Toxoplasma gondii in a series of heart transplant recipients.

    PubMed Central

    Sluiters, J F; Balk, A H; Essed, C E; Mochtar, B; Weimar, W; Simoons, M L; Ijzerman, E P

    1989-01-01

    Toxoplasma gondii infections in heart transplant recipients were monitored by indirect enzyme-linked immunosorbent assay for immunoglobulin G (ELISA-IgG), indirect ELISA-IgM in serum IgM fractions, antibody capture ELISA-IgM, IgM-immunosorbent agglutination assay (ISAGA), and IgM immunoblotting. Basic immunosuppression consisted of cyclosporine and low-dose steroids. Before transplantation, 26 of 43 recipients showed serological evidence of infection. In serum samples from 15 (35%) recipients, specific antibodies were not detected. Approximately 50% of the heart donors, were toxoplasma seropositive. Eight of the fifteen seronegative recipients received hearts from toxoplasma-seropositive donors. In four of the eight recipients, seroconversion could be demonstrated with all tests used. In three of these four patients, clinical disease developed. One patient with strong serological evidence of toxoplasmosis died, but toxoplasma parasites and antigens were not detected at autopsy. In two patients, toxoplasma cysts were found in cardiac biopsies. Seroconversion was not prevented by the use of spiramycin prophylaxis in two recipients. Reactivations of latent infections or reinfections were detected by indirect ELISA in six (23%) seropositive recipients, but symptoms and signs of active T. gondii infection were not seen. Seroconversion and reactivation of infection were readily found by a combined use of indirect ELISA-IgG and ELISA-IgM and antibody capture ELISA-IgM. Discrepancies in results could be examined by immunoblotting. IgM-ISAGA retained stable positive values longer than IgM-ELISAs did. Cyclosporine treatment did not hamper detection of seroconversion but could cause antibody levels to remain relatively low in primary infections. Seronegative recipients should receive antitoxoplasma treatment on seroconversion. PMID:2654182

  17. Evaluation of activity monitors in manual wheelchair users with paraplegia

    PubMed Central

    Hiremath, Shivayogi V.; Ding, Dan

    2011-01-01

    Objective The aim of this study was to evaluate the performance of SenseWear® (SW) and RT3 activity monitors (AMs) in estimating energy expenditure (EE) in manual wheelchair users (MWUs) with paraplegia for a variety of physical activities. Methods Twenty-four subjects completed four activities including resting, wheelchair propulsion, arm-ergometry exercise, and deskwork. The criterion EE was measured by a K4b2 portable metabolic cart. The EE estimated by the SW and RT3 were compared with the criterion EE by the absolute differences and absolute percentage errors. Intraclass correlations and the Bland and Altman plots were also used to assess the agreements between the two AMs and the metabolic cart. Correlations between the criterion EE and the estimated EE and sensors data from the AMs were evaluated. Results The EE estimation errors for the AMs varied from 24.4 to 125.8% for the SW and from 22.0 to 52.8% for the RT3. The intraclass correlation coefficients (ICCs) between the criterion EE and the EE estimated by the two AMs for each activity and all activities as a whole were considered poor with all the ICCs smaller than 0.75. Except for deskwork, the EE from the SW was more correlated to the criterion EE than the EE from the RT3. Conclusion The results indicate that neither of the AMs is an appropriate tool for quantifying physical activity in MWUs with paraplegia. However, the accuracy of EE estimation could be potentially improved by building new regression models based on wheelchair-related activities. PMID:21528634

  18. Clinical value of monitoring eosinophil activity in asthma.

    PubMed Central

    Koller, D Y; Herouy, Y; Götz, M; Hagel, E; Urbanek, R; Eichler, I

    1995-01-01

    To evaluate the use of eosinophil cationic protein (ECP) in monitoring disease activity in childhood asthma, serum ECP in 175 asthmatic children was assessed. Forty five patients with cystic fibrosis, 23 with lower respiratory tract infections (LRTI), and 87 healthy children were used as controls. Serum ECP concentrations (34.3 micrograms/l v 9.8 micrograms/l) were significantly higher in children with bronchial asthma than in healthy control subjects. In symptomatic patients with asthma serum ECP concentrations were increased compared with those from asymptomatic patients (40.2 micrograms/l v 14.4 micrograms/l), irrespective of treatment modalities (that is steroids, beta 2 agonists, or sodium cromoglycate). Moreover, atopy and infection appeared to be factors enhancing eosinophil activity in bronchial asthma as measured by serum ECP (58.4 micrograms/l v 36.8 micrograms/l and 68.8 micrograms/l v 42.2 micrograms/l, respectively). In a longitudinal trial, antiasthmatic treatment modalities (that is steroids) reduced serum ECP within four weeks (42.2 micrograms/l v 19.0 micrograms/l). In conclusion, the data indicate that (1) eosinophils also play a central part in childhood asthma; (2) serum concentrations of ECP in children with bronchial asthma are related to the disease severity and may thus be used for monitoring inflammation in childhood asthma; (3) eosinophil activity appears to be enhanced by atopy and infection; and (4) longitudinal measurements of serum ECP concentrations may be useful for optimising anti-inflammatory treatment in children with bronchial asthma. PMID:8554357

  19. Clean Air Excellence Award Recipients

    EPA Pesticide Factsheets

    Recipients are organized by award category within each year: Clean Air Technology, Community Action, Education/Outreach, Regulatory/Policy Innovations, Transportation Efficiency Innovations, Thomas W. Zosel individual, and Gregg Cooke Visionary Program.

  20. IDEEA activity monitor: validity of activity recognition for lying, reclining, sitting and standing.

    PubMed

    Jiang, Yuyu; Larson, Janet L

    2013-03-01

    Recent evidence demonstrates the independent negative effects of sedentary behavior on health, but there are few objective measures of sedentary behavior. Most instruments measure physical activity and are not validated as measures of sedentary behavior. The purpose of this study was to evaluate the validity of the IDEEA system's measures of sedentary and low-intensity physical activities: lying, reclining, sitting and standing. Thirty subjects, 14 men and 16 women, aged 23 to 77 years, body mass index (BMI) between 18 to 34 kg/m(2), participated in the study. IDEEA measures were compared to direct observation for 27 activities: 10 lying in bed, 3 lying on a sofa, 1 reclining in a lawn chair, 10 sitting and 3 standing. Two measures are reported, the percentage of activities accurately identified and the percentage of monitored time that was accurately labeled by the IDEEA system for all subjects. A total of 91.6% of all observed activities were accurately identified and 92.4% of the total monitored time was accurately labeled. The IDEEA system did not accurately differentiate between lying and reclining so the two activities were combined for calculating accuracy. Using this approach the IDEEA system accurately identified 96% of sitting activities for a total of 97% of the monitored sitting time, 99% and 99% for standing, 87% and 88% for lying in bed, 87% and 88% for lying on the sofa, and 83% and 83% for reclining on a lawn chair. We conclude that the IDEEA system accurately recognizes sitting and standing positions, but it is less accurate in identifying lying and reclining positions. We recommend combining the lying and reclining activities to improve accuracy. The IDEEA system enables researchers to monitor lying, reclining, sitting and standing with a reasonable level of accuracy and has the potential to advance the science of sedentary behaviors and low-intensity physical activities.

  1. Single-Molecule Electronic Monitoring of DNA Polymerase Activity

    NASA Astrophysics Data System (ADS)

    Marushchak, Denys O.; Pugliese, Kaitlin M.; Turvey, Mackenzie W.; Choi, Yongki; Gul, O. Tolga; Olsen, Tivoli J.; Rajapakse, Arith J.; Weiss, Gregory A.; Collins, Philip G.

    Single-molecule techniques can reveal new spatial and kinetic details of the conformational changes occurring during enzymatic catalysis. Here, we investigate the activity of DNA polymerases using an electronic single-molecule technique based on carbon nanotube transistors. Single molecules of the Klenow fragment (KF) of polymerase I were conjugated to the transistors and then monitored via fluctuations in electrical conductance. Continuous, long-term monitoring recorded single KF molecules incorporating up to 10,000 new bases into single-stranded DNA templates. The duration of individual incorporation events was invariant across all analog and native nucleotides, indicating that the precise structure of different base pairs has no impact on the timing of incorporation. Despite similar timings, however, the signal magnitudes generated by certain analogs reveal alternate conformational states that do not occur with native nucleotides. The differences induced by these analogs suggest that the electronic technique is sensing KF's O-helix as it tests the stability of nascent base pairs.

  2. Design, Synthesis, and Monitoring of Light-Activated Motorized Nanomachines

    NASA Astrophysics Data System (ADS)

    Chiang, Pinn-Tsong

    Our group has developed a family of single molecules termed nanocars, which are aimed at performing controllable motion on surfaces. In this work, a series of light-activated motorized nanomachines incorporated with a MHz frequency light-activated unidirectional rotary motor were designed and synthesized. We hope the light-activated motor can serve as the powering unit for the nanomachines, and perform controllable translational motion on surfaces or in solution. A series of motorized nanovehicles intended for scanning tunneling microscopy (STM) imaging were designed and synthesized. A p-carborane-wheeled motorized nanocar was synthesized and monitored by STM. Single-molecule imaging was accomplished on a Cu(111) surface. However, further manipulations did lead to motor induced lateral motion. We attributed this result to the strong molecule-surface interactions between the p-carborane-wheeled nanocar and the Cu(111) surface and possible energy transfer between the rotary motor and the Cu(111) surface. To fine-tune the molecule-surface interactions, an adamantane-wheeled motorized nanocar and a three-wheel nanoroadster were designed and synthesized. In addition, the STM substrates will be varied and different combinations of molecule-surface interactions will be studied. As a complimentary imaging method to STM, single-molecule fluorescence microscopy (SMFM) also provides single-molecule level resolution. Unlike STM experiment requires ultra-high vacuum and conductive substrate, SMFM experiment is conducted at ambient conditions and uses non-conductive substrate. This imaging method allows us to study another category of molecule-surface interactions. We plan to design a fluorescent motorized nanocar that is suitable for SMFM studies. However, both the motor and fluorophore are photochemically active molecules. In proximity, some undesired energy transfer or interference could occur. A cyanine 5- (cy5-) tagged motorized nanocar incorporated with the MHz motor was

  3. Multi-level continuous active source seismic monitoring (ML-CASSM): Application to shallow hydrofracture monitoring

    NASA Astrophysics Data System (ADS)

    Ajo Franklin, J. B.; Daley, T. M.; Butler-Veytia, B.; Peterson, J.; Gasperikova, E.; Hubbard, S. S.

    2010-12-01

    Induced subsurface processes occur over a wide variety of time scales ranging from seconds (e.g. fracture initiation) to days (e.g. unsteady multiphase flow) and weeks (e.g. induced mineral precipitation). Active source seismic monitoring has the potential to dynamically characterize such alterations and allow estimation of spatially localized rates. However, even optimal timelapse seismic surveys have limited temporal resolution due to both the time required to acquire a survey and the cost of continuous field deployment of instruments and personnel. Traditional timelapse surveys are also limited by experimental repeatability due to a variety of factors including geometry replication and near-surface conditions. Recent research has demonstrated the value of semi-permanently deployed seismic systems with fixed sources and receivers for use in monitoring a variety of processes including near-surface stress changes (Silver et.al. 2007), subsurface movement of supercritical CO2 (Daley et.al. 2007), and preseismic velocity changes in fault regions (Niu et. al. 2008). This strategy, referred to as continuous active source seismic monitoring (CASSM), allows both precise quantification of traveltime changes on the order of 1.1 x 10-7 s and temporal sampling on the order of minutes. However, as previously deployed, CASSM often sacrifices spatial resolution for temporal resolution with previous experiments including only a single source level. We present results from the first deployment of CASSM with a large number of source levels under automated control. Our system is capable of autonomously acquiring full tomographic datasets (10 sources, 72 receivers) in 3 minutes without human intervention, thus allowing active source seismic imaging (rather than monitoring) of processes with short durations. Because no sources or receivers are moved in the acquisition process, signal repeatability is excellent and subtle waveform changes can be interpreted with increased confidence

  4. Use of Small Fluorescent Molecules to Monitor Channel Activity

    NASA Astrophysics Data System (ADS)

    Jones, Sharon; Stringer, Sarah; Naik, Rajesh; Stone, Morley

    2001-03-01

    The Mechanosensitive channel of Large conductance (MscL) allows bacteria to rapidly adapt to changing environmental conditions such as osmolarity. The MscL channel opens in response to increases in membrane tension, which allows for the efflux of cytoplasmic constituents. Here we describe the cloning and expression of Salmonella typhimurium MscL (St-MscL). Using a fluorescence efflux assay, we demonstrate that efflux through the MscL channel during hypoosmotic shock can be monitored using endogenously produced fluorophores. In addition, we observe that thermal stimulation, i.e., heat shock, can also induce efflux through MscL. We present the first evidence of thermal activation of MscL efflux by heat shocking cells expressing the S. typhimurium protein variant. This finding has significant biosensor implications, especially for investigators exploring the use of channel proteins in biosensor applications. Thermal biosensors are relatively unexplored, but would have considerable commercial and military utility.

  5. Automatic Video System for Continues Monitoring of the Meteor Activity

    NASA Astrophysics Data System (ADS)

    Koten, Pavel; Fliegel, Karel; Vítek, Stanislav; Páta, Petr

    2011-05-01

    In this paper we present current progress in development of new observational instruments for the double station video experiment. The Meteor Automatic Imager and Analyser (MAIA) system is based on digital monochrome camera JAI CM-040 and well proved image intensifier XX1332. Both the observations as well as the data processing will be fully automatic. We are expecting the recorded data of better quality and both spatial and time resolution in comparison with currently used analogue system. The main goal of the MAIA project is to monitor activity of the meteor showers and sporadic meteor each night for the period of at least 3 years. First version of the system was already assembled and has been intensively tested in the optical laboratory. Optical properties were measured and the result confirmed our expectations according to image quality and resolution. First night sky observation was already carried out.

  6. Aerial monitoring in active mud volcano by UAV technique

    NASA Astrophysics Data System (ADS)

    Pisciotta, Antonino; Capasso, Giorgio; Madonia, Paolo

    2016-04-01

    UAV photogrammetry opens various new applications in the close range domain, combining aerial and terrestrial photogrammetry, but also introduces low-cost alternatives to the classical manned aerial photogrammetry. Between 2014 and 2015 tree aerial surveys have been carried out. Using a quadrotor drone, equipped with a compact camera, it was possible to generate high resolution elevation models and orthoimages of The "Salinelle", an active mud volcanoes area, located in territory of Paternò (South Italy). The main risks are related to the damages produced by paroxysmal events. Mud volcanoes show different cyclic phases of activity, including catastrophic events and periods of relative quiescence characterized by moderate activity. Ejected materials often are a mud slurry of fine solids suspended in liquids which may include water and hydrocarbon fluids, the bulk of released gases are carbon dioxide, with some methane and nitrogen, usually pond-shaped of variable dimension (from centimeters to meters in diameter). The scope of the presented work is the performance evaluation of a UAV system that was built to rapidly and autonomously acquire mobile three-dimensional (3D) mapping data in a volcanic monitoring scenario.

  7. Detection of physical activities using a physical activity monitor system for wheelchair users.

    PubMed

    Hiremath, Shivayogi V; Intille, Stephen S; Kelleher, Annmarie; Cooper, Rory A; Ding, Dan

    2015-01-01

    Availability of physical activity monitors for wheelchair users can potentially assist these individuals to track regular physical activity (PA), which in turn could lead to a healthier and more active lifestyle. Therefore, the aim of this study was to develop and validate algorithms for a physical activity monitoring system (PAMS) to detect wheelchair based activities. The PAMS consists of a gyroscope based wheel rotation monitor (G-WRM) and an accelerometer device (wocket) worn on the upper arm or on the wrist. A total of 45 persons with spinal cord injury took part in the study, which was performed in a structured university-based laboratory environment, a semi-structured environment at the National Veterans Wheelchair Games, and in the participants' home environments. Participants performed at least ten PAs, other than resting, taken from a list of PAs. The classification performance for the best classifiers on the testing dataset for PAMS-Arm (G-WRM and wocket on upper arm) and PAMS-Wrist (G-WRM and wocket on wrist) was 89.26% and 88.47%, respectively. The outcomes of this study indicate that multi-modal information from the PAMS can help detect various types of wheelchair-based activities in structured laboratory, semi-structured organizational, and unstructured home environments.

  8. INDIRECT MEASUREMENT OF BIOLOGICAL ACTIVITY TO MONITOR NATURAL ATTENUATION

    EPA Science Inventory

    The remediation of ground water contamination by natural attenuation, specifically biodegradation, requires continual monitoring. This research is aimed at improving methods for evaluating the long-term performance of Monitored Natural Attenuation (MNA), specifically changes in ...

  9. [Development of a wearable electrocardiogram monitor with recognition of physical activity scene].

    PubMed

    Wang, Zihong; Wu, Baoming; Yin, Jian; Gong, Yushun

    2012-10-01

    To overcome the problems of current electrocardiogram (ECG) tele-monitoring devices used for daily life, according to information fusion thought and by means of wearable technology, we developed a new type of wearable ECG monitor with the capability of physical activity recognition in this paper. The ECG monitor synchronously detected electrocardiogram signal and body acceleration signal, and recognized the scene information of physical activity, and finally determined the health status of the heart. With the advantages of accuracy for measurement, easy to use, comfort to wear, private feelings and long-term continuous in monitoring, this ECG monitor is quite fit for the heart-health monitoring in daily life.

  10. Viral Infection in Renal Transplant Recipients

    PubMed Central

    Cukuranovic, Jovana; Ugrenovic, Sladjana; Jovanovic, Ivan; Visnjic, Milan; Stefanovic, Vladisav

    2012-01-01

    Viruses are among the most common causes of opportunistic infection after transplantation. The risk for viral infection is a function of the specific virus encountered, the intensity of immune suppression used to prevent graft rejection, and other host factors governing susceptibility. Although cytomegalovirus is the most common opportunistic pathogen seen in transplant recipients, numerous other viruses have also affected outcomes. In some cases, preventive measures such as pretransplant screening, prophylactic antiviral therapy, or posttransplant viral monitoring may limit the impact of these infections. Recent advances in laboratory monitoring and antiviral therapy have improved outcomes. Studies of viral latency, reactivation, and the cellular effects of viral infection will provide clues for future strategies in prevention and treatment of viral infections. This paper will summarize the major viral infections seen following transplant and discuss strategies for prevention and management of these potential pathogens. PMID:22654630

  11. Using VHF Lightning Observations to Monitor Explosive Volcanic Activity

    NASA Astrophysics Data System (ADS)

    Behnke, S. A.; Thomas, R. J.; McNutt, S. R.; Krehbiel, P. R.; Rison, W.; Edens, H. E.

    2011-12-01

    Lightning is an integral part of explosive volcanic eruptions and volcanic lightning measurements are a useful tool for volcano monitoring. VHF measurements of volcanic lightning can be made remotely, at distances of up to 100 km. A strategically placed network of 6 or more VHF ground stations could locate lightning in eruption columns from several regional volcanoes, and a minimum of two stations could be used to monitor a single volcano. Such a network would be particularly useful for detection or confirmation of explosive activity in situations where volcanoes are remotely located, and thus lack visual observations, or are not well instrumented with seismic networks. Furthermore, clouds are fully transparent to VHF signals, making lightning detection possible even when weather obscures visual observations. Recent VHF observations of volcanic lightning at Augustine Volcano (Alaska, USA, 2006), Redoubt Volcano (Alaska, USA, 2009) and Eyjafjallajökull (Iceland, 2010) have shown that two basic types of VHF signals are observed during volcanic eruptions, one of which is unique to volcanic activity. The unique signal, referred to as a 'continual RF' signal, was caused by very high rates of small 'vent discharges' occurring directly above the vent in the eruption column and was unlike any observations of lightning in meteorological thunderstorms. Vent discharges were observed to begin immediately following an explosive eruption. The second type of signal is from conventional lightning discharges, such as upward directed 'near-vent lightning' and isolated 'plume lightning.' Near-vent lightning was observed to begin 1-2 minutes following the onset of an explosive eruption while plume lightning began 4 or more minutes after the onset. At Redoubt the plume lightning occurred at such high rates that it rivaled lightning rates of supercell thunderstorms on the Great Plains of the United States. While both types of lightning signals can be used as indicators that explosive

  12. Performance of a coincidence based blood activity monitor

    SciTech Connect

    Moses, W.W.

    1989-12-01

    A new device has been constructed that measures the positron emitting radio-tracer concentration in arterial blood by extracting blood with a peristaltic pump, then measuring the activity concentration by detecting coincident pairs of 511 keV photons with a pair of heavy inorganic scintillators attached to photomultiplier tubes. The sensitivity of this device is experimentally determined to be 610 counts/second per {mu}Ci/ml, and has a paralyzing dead time of 1.2 {mu}s, so is capable of measuring blood activity concentration as high as 1 mCi/ml. Its performance is compared to two other blood monitoring methods: discrete blood samples counted with a well counter and device that uses a plastic scintillator to directly detect positrons. The positron detection efficiency of this device for {sup 18}F is greater than the plastic scintillation counter, and also eliminates the radioisotope dependent correction factors necessary to convert count rate to absolute concentration. Coincident photon detection also has the potential of reducing the background compared to direct positron detection, thereby increasing the minimum detectable isotope concentration. 10 refs., 6 figs.

  13. Smart helmet: Monitoring brain, cardiac and respiratory activity.

    PubMed

    von Rosenberg, Wilhelm; Chanwimalueang, Theerasak; Goverdovsky, Valentin; Mandic, Danilo P

    2015-01-01

    The timing of the assessment of the injuries following a road-traffic accident involving motorcyclists is absolutely crucial, particularly in the events with head trauma. Standard apparatus for monitoring cardiac activity is usually attached to the limbs or the torso, while the brain function is routinely measured with a separate unit connected to the head-mounted sensors. In stark contrast to these, we propose an integrated system which incorporates the two functionalities inside an ordinary motorcycle helmet. Multiple fabric electrodes were mounted inside the helmet at positions featuring good contact with the skin at different sections of the head. The experimental results demonstrate that the R-peaks (and therefore the heart rate) can be reliably extracted from potentials measured with electrodes on the mastoids and the lower jaw, while the electrodes on the forehead enable the observation of neural signals. We conclude that various vital sings and brain activity can be readily recorded from the inside of a helmet in a comfortable and inconspicuous way, requiring only a negligible setup effort.

  14. Active Learning Framework for Non-Intrusive Load Monitoring: Preprint

    SciTech Connect

    Jin, Xin

    2016-05-16

    Non-Intrusive Load Monitoring (NILM) is a set of techniques that estimate the electricity usage of individual appliances from power measurements taken at a limited number of locations in a building. One of the key challenges in NILM is having too much data without class labels yet being unable to label the data manually for cost or time constraints. This paper presents an active learning framework that helps existing NILM techniques to overcome this challenge. Active learning is an advanced machine learning method that interactively queries a user for the class label information. Unlike most existing NILM systems that heuristically request user inputs, the proposed method only needs minimally sufficient information from a user to build a compact and yet highly representative load signature library. Initial results indicate the proposed method can reduce the user inputs by up to 90% while still achieving similar disaggregation performance compared to a heuristic method. Thus, the proposed method can substantially reduce the burden on the user, improve the performance of a NILM system with limited user inputs, and overcome the key market barriers to the wide adoption of NILM technologies.

  15. Targeted Proteomics Approaches To Monitor Microbial Activity In Basalt Aquifer

    NASA Astrophysics Data System (ADS)

    Paszczynski, A. J.; Paidisetti, R.

    2007-12-01

    Microorganisms play a major role in biogeochemical cycles of the Earth. Information regarding microbial community composition can be very useful for environmental monitoring since the short generation times of microorganisms allows them to respond rapidly to changing environmental conditions. Microbial mediated attenuation of toxic chemicals offers great potential for the restoration of contaminated environments in an ecologically acceptable manner. Current knowledge regarding the structure and functional activities of microbial communities is limited, but more information is being acquired every day through many genomic- and proteomic- based methods. As of today, only a small fraction of the Earth's microorganisms has been cultured, and so most of the information regarding the biodegradation and therapeutic potentials of these uncultured microorganisms remains unknown. Sequence analysis of DNA and/or RNA has been used for identifying specific microorganisms, to study the community composition, and to monitor gene expression providing limited information about metabolic state of given microbial system. Proteomic studies can reveal information regarding the real-time metabolic state of the microbial communities thereby aiding in understanding their interaction with the environment. In research described here the involvement of microbial communities in the degradation of anthropogenic contaminants such as trichloroethylene (TCE) was studied using mass spectrometry-based proteomics. The co- metabolic degradation of TCE in the groundwater of the Snake River Plain Aquifer at the Test Area North (TAN) site of Idaho National Laboratory (INL) was monitored by the characterization of peptide sequences of enzymes such as methane monooxygenases (MMOs). MMOs, expressed by methanotrophic bacteria are involved in the oxidation of methane and non-specific co-metabolic oxidation of TCE. We developed a time- course cell lysis method to release proteins from complex microbial

  16. A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells.

    PubMed

    O'Brien, Martha; Moehring, Danielle; Muñoz-Planillo, Raúl; Núñez, Gabriel; Callaway, Justin; Ting, Jenny; Scurria, Mike; Ugo, Tim; Bernad, Laurent; Cali, James; Lazar, Dan

    2017-03-04

    Inflammasomes are protein complexes induced by diverse inflammatory stimuli that activate caspase-1, resulting in the processing and release of cytokines, IL-1β and IL-18, and pyroptosis, an immunogenic form of cell death. To provide a homogeneous method for detecting caspase-1 activity, we developed a bioluminescent, plate-based assay that combines a substrate, Z-WEHD-aminoluciferin, with a thermostable luciferase in an optimized lytic reagent added directly to cultured cells. Assay specificity for caspase-1 is conferred by inclusion of a proteasome inhibitor in the lytic reagent and by use of a caspase-1 inhibitor to confirm activity. This approach enables a specific and rapid determination of caspase-1 activation. Caspase-1 activity is stable in the reagent thereby providing assay convenience and flexibility. Using this assay system, caspase-1 activation has been determined in THP-1 cells following treatment with α-hemolysin, LPS, nigericin, gramicidin, MSU, R848, Pam3CSK4, and flagellin. Caspase-1 activation has also been demonstrated in treated J774A.1 mouse macrophages, bone marrow-derived macrophages (BMDMs) from mice, as well as in human primary monocytes. Caspase-1 activity was not detected in treated BMDMs derived from Casp1(-/-) mice, further confirming the specificity of the assay. Caspase-1 activity can be measured directly in cultured cells using the lytic reagent, or caspase-1 activity released into medium can be monitored by assay of transferred supernatant. The caspase-1 assay can be multiplexed with other assays to monitor additional parameters from the same cells, such as IL-1β release or cell death. The caspase-1 assay in combination with a sensitive real-time monitor of cell death allows one to accurately establish pyroptosis. This assay system provides a rapid, convenient, and flexible method to specifically and quantitatively monitor caspase-1 activation in cells in a plate-based format. This will allow a more efficient and effective

  17. Successional Distance between the Source and Recipient Influence Seed Germination and Seedling Survival during Surface Soil Replacement in SW China

    PubMed Central

    Shen, You-xin; Gao, Lei; Xia, Xue; Li, Yuhui; Guan, Huilin

    2013-01-01

    Adding propagules (source) to a degraded site (recipient) is a common way of manipulating secondary succession to restore diversity and services formerly provided by forests. However, heretofore no study has considered the effect of “successional distance” between source and recipient site. Four sites in the Shilin karst area of SW China were treated as different states along a secondary successional sere: grass, shrub, young secondary forest, and primary forest. Ten 1 m ×1m soil quadrats in the grass, shrub and young forest sites were replaced with 10 cm deep soil sources from corresponding later successional stage(s) in January 2009. Woody plant seed germination was monitored in the first year and seedling survival was monitored until the end of the second year. At the end of 2010, 2097 seeds of woody plants belonging to 45 taxa had germinated, and 3.9% of the seedlings and 7.8% of the species survived. Germination of most species was sensitive to ambient light (red, far-red, R:FR ratios, photosynthetically active radiation). Soil source and recipient site had a significant effect on the total number of seeds and number of species that germinated, and on the percentage of seedlings that survived through the end of the second year. Closer successional stages between recipient site and soil source had higher seed germination and seedling-survival percentages. However, a transition threshold exists in the young forest state, where seeds can germinate but not survive the second year. Our results, although based on an unreplicated chronosequence, suggest that successional distance between soil sources and recipient sites affect forest recruitment and restoration in degraded karst of SW China. PMID:24223891

  18. Geophysical Monitoring of Microbial Activity within a Wetland Soil

    NASA Astrophysics Data System (ADS)

    O'Brien, M.; Zhang, C.; Ntarlagiannis, D.; Slater, L.; Yee, N.

    2007-05-01

    We performed Induced Polarization (IP) and Self Potential (SP) measurements to record the geoelectrical signatures of microbial activity within a wetland soil. The experiment was conducted in laboratory, utilizing an open flow column set up. Soil samples from Kearny Marsh (KM), a shallow water wetland, were collected and stored at 4o Celsius prior to the start of the experiment. Two columns were dry packed with a mix of KM soil and sterile Ottawa sand (50% by weight). One column was sterilized and used as a control while the other column retained the biologically active soil sample. Both columns were saturated with a minimal salts medium capable of supporting microbial life; after saturation, a steady flow rate of one pore volume per day was maintained throughout the experiment. Ambient temperature and pressure changes (at the inflow and outflow of each column) were continuously monitored throughout the experiment. Common geochemical parameters, such as Eh, pH, and fluid conductivity were measured at the inflow and outflow of each column at regular intervals. IP and SP responses were continuously recorded on both columns utilizing a series of electrodes along the column length; additionally for the SP measurements we used a reference electrode at the inflow tube. Strong SP anomalies were observed for all the locations along the active column. Black visible mineral precipitant also formed in the active column. The observed precipitation coincided with the times that SP anomalies developed at each electrode position. These responses are associated with microbial induced sulfide mineralization. We interpret the SP signal as the result of redox processes associated with this mineralization driven by gradients in ionic concentration and mobility within the column, similar to a galvanic cell mechanism. IP measurements show no correlation with these visual and SP responses. Destructive analysis of the samples followed the termination of the experiment. Scanning electron

  19. Physical Activity Measured by Physical Activity Monitoring System Correlates with Glucose Trends Reconstructed from Continuous Glucose Monitoring

    PubMed Central

    Zecchin, Chiara; Facchinetti, Andrea; Sparacino, Giovanni; Dalla Man, Chiara; Manohar, Chinmay; Levine, James A.; Basu, Ananda; Kudva, Yogish C.

    2013-01-01

    Abstract Background In type 1 diabetes mellitus (T1DM), physical activity (PA) lowers the risk of cardiovascular complications but hinders the achievement of optimal glycemic control, transiently boosting insulin action and increasing hypoglycemia risk. Quantitative investigation of relationships between PA-related signals and glucose dynamics, tracked using, for example, continuous glucose monitoring (CGM) sensors, have been barely explored. Subjects and Methods In the clinic, 20 control and 19 T1DM subjects were studied for 4 consecutive days. They underwent low-intensity PA sessions daily. PA was tracked by the PA monitoring system (PAMS), a system comprising accelerometers and inclinometers. Variations on glucose dynamics were tracked estimating first- and second-order time derivatives of glucose concentration from CGM via Bayesian smoothing. Short-time effects of PA on glucose dynamics were quantified through the partial correlation function in the interval (0, 60 min) after starting PA. Results Correlation of PA with glucose time derivatives is evident. In T1DM, the negative correlation with the first-order glucose time derivative is maximal (absolute value) after 15 min of PA, whereas the positive correlation is maximal after 40–45 min. The negative correlation between the second-order time derivative and PA is maximal after 5 min, whereas the positive correlation is maximal after 35–40 min. Control subjects provided similar results but with positive and negative correlation peaks anticipated of 5 min. Conclusions Quantitative information on correlation between mild PA and short-term glucose dynamics was obtained. This represents a preliminary important step toward incorporation of PA information in more realistic physiological models of the glucose–insulin system usable in T1DM simulators, in development of closed-loop artificial pancreas control algorithms, and in CGM-based prediction algorithms for generation of hypoglycemic alerts. PMID

  20. 40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... August 30, 1999 Other Monitoring Requirements § 62.15275 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans...

  1. 40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... August 30, 1999 Other Monitoring Requirements § 62.15275 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans...

  2. 40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... August 30, 1999 Other Monitoring Requirements § 62.15275 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans...

  3. 40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... August 30, 1999 Other Monitoring Requirements § 62.15275 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans...

  4. 40 CFR 62.15275 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... activated carbon? 62.15275 Section 62.15275 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... August 30, 1999 Other Monitoring Requirements § 62.15275 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans...

  5. Lunar Dust and Lunar Simulant Activation and Monitoring

    NASA Technical Reports Server (NTRS)

    Wallace, W. T.; Hammond, D. K.; Jeevarajan, A. S.

    2008-01-01

    . Respir. Dis. 138 (1988) 1213-1219). The size and cost of these instruments makes them unattractive for the monitoring of lunar dust activity. A more suitable technique is based on the change in fluorescence of a molecule upon reaction with a hydroxyl radical (or other radical species). Fluorescence instruments are much less costly and bulky than ESR spectrometers, and small fluorescence sensors for space missions have already been developed (F. Gao, et al., J. Biomed. Opt. 10 (2005) 054005). For the current fluorescence studies, the terephthalate molecule has been chosen for monitoring the production of hydroxyl radicals in solution. As shown in Scheme 1, the reaction between the non-fluorescent terephthalate molecule and a hydroxyl radical produces the highly-fluorescent 2-hydroxyterephthalate molecule.

  6. Jovian dust streams: A monitor of Io's volcanic plume activity

    USGS Publications Warehouse

    Kruger, H.; Geissler, P.; Horanyi, M.; Graps, A.L.; Kempf, S.; Srama, R.; Moragas-Klostermeyer, G.; Moissl, R.; Johnson, T.V.; Grun, E.

    2003-01-01

    Streams of high speed dust particles originate from Jupiter's moon Io. After release from Io, the particles collect electric charges in the Io plasma torus, gain energy from the co-rotating electric field of Jupiter's magnetosphere, and leave the Jovian system into interplanetary space with escape speeds over 200 km s-1. The Galileo spacecraft has continuously monitored the dust streams during 34 revolutions about Jupiter between 1996 and 2002. The observed dust fluxes exhibit large orbit-to-orbit variability due to systematic and stochastic changes. After removal of the systematic variations, the total dust emission rate of Io has been calculated. It varies between 10-3 and 10 kg s-1, and is typically in the range of 0.1 to 1 kg s-1. We compare the dust emission rate with other markers of volcanic activity on Io like large-area surface changes caused by volcanic deposits and sightings of volcanic plumes. Copyright 2003 by the American Geophysical Union.

  7. Apollo Director Phillips Monitors Apollo 11 Pre-Launch Activities

    NASA Technical Reports Server (NTRS)

    1969-01-01

    From the Kennedy Space Flight Center (KSC) control room, Apollo Program Director Lieutenant General Samuel C. Phillips monitors pre-launch activities for Apollo 11. The Apollo 11 mission, the first lunar landing mission, launched from the KSC in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, 'Columbia', piloted by Collins, remained in a parking orbit around the Moon while the LM, 'Eagle'', carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  8. Laser activated nanothermolysis of leukemia cells monitored by photothermal microscopy

    NASA Astrophysics Data System (ADS)

    Lapotko, Dmitri; Lukianova, Ekaterina; Shnip, Alexander; Zheltov, George; Potapnev, Michail; Savitsky, Valeriy; Klimovich, Olga; Oraevsky, Alexander

    2005-04-01

    We are developing new diagnostic and therapeutic technologies for leukemia based on selective targeting of leukemia cells with gold nanoparticles and thermomechanical destruction of the tumor cells with laser-induced microbubbles. Clusters of spherical gold nanoparticles that have strong optical absorption of laser pulses at 532 nm served as nucleation sites of vapor microbubbles. The nanoparticles were targeted selectively to leukemia cells using leukemia-specific surface receptors and a set of two monoclonal antibodies. Application of a primary myeloid-specific antibody to tumor cells followed by targeting the cells with 30-nm nanoparticles conjugated with a secondary antibody (IgG) resulted in formation of nanoparticulate clusters due to aggregation of IgGs. Formation of clusters resulted in substantial decrease of the damage threshold for target cells. The results encourage development of Laser Activated Nanothermolysis as a Cell Elimination Therapy (LANCET) for leukemia. The proposed technology can be applied separately or in combination with chemotherapy for killing leukemia cells without damage to other blood cells. Potential applications include initial reduction of concentration of leukemia cells in blood prior to chemotherapy and treatment of residual tumor cells after the chemotherapy. Laser-induced bubbles in individual cells and cell damage were monitored by analyzing profile of photothermal response signals over the entire cell after irradiation with a single 10-ns long laser pulse. Photothermal microscopy was utilized for imaging formation of microbubbles around nanoparticulate clusters.

  9. Cooperative wireless network control based health and activity monitoring system.

    PubMed

    Prakash, R; Ganesh, A Balaji; Girish, Siva V

    2016-10-01

    A real-time cooperative communication based wireless network is presented for monitoring health and activity of an end-user in their environment. The cooperative communication offers better energy consumption and also an opportunity to aware the current location of a user non-intrusively. The link between mobile sensor node and relay node is dynamically established by using Received Signal Strength Indicator (RSSI) and Link Quality Indicator (LQI) based on adaptive relay selection scheme. The study proposes a Linear Acceleration based Transmission Power Decision Control (LA-TPDC) algorithm to further enhance the energy efficiency of cooperative communication. Further, the occurrences of false alarms are carefully prevented by introducing three stages of sequential warning system. The real-time experiments are carried-out by using the nodes, namely mobile sensor node, relay nodes and a destination node which are indigenously developed by using a CC430 microcontroller integrated with an in-built transceiver at 868 MHz. The wireless node performance characteristics, such as energy consumption, Signal-Noise ratio (SNR), Bit Error Rate (BER), Packet Delivery Ratio (PDR) and transmission offset are evaluated for all the participated nodes. The experimental results observed that the proposed linear acceleration based transmission power decision control algorithm almost doubles the battery life time than energy efficient conventional cooperative communication.

  10. Step detection and activity recognition accuracy of seven physical activity monitors.

    PubMed

    Storm, Fabio A; Heller, Ben W; Mazzà, Claudia

    2015-01-01

    The aim of this study was to compare the seven following commercially available activity monitors in terms of step count detection accuracy: Movemonitor (Mc Roberts), Up (Jawbone), One (Fitbit), ActivPAL (PAL Technologies Ltd.), Nike+ Fuelband (Nike Inc.), Tractivity (Kineteks Corp.) and Sensewear Armband Mini (Bodymedia). Sixteen healthy adults consented to take part in the study. The experimental protocol included walking along an indoor straight walkway, descending and ascending 24 steps, free outdoor walking and free indoor walking. These tasks were repeated at three self-selected walking speeds. Angular velocity signals collected at both shanks using two wireless inertial measurement units (OPAL, ADPM Inc) were used as a reference for the step count, computed using previously validated algorithms. Step detection accuracy was assessed using the mean absolute percentage error computed for each sensor. The Movemonitor and the ActivPAL were also tested within a nine-minute activity recognition protocol, during which the participants performed a set of complex tasks. Posture classifications were obtained from the two monitors and expressed as a percentage of the total task duration. The Movemonitor, One, ActivPAL, Nike+ Fuelband and Sensewear Armband Mini underestimated the number of steps in all the observed walking speeds, whereas the Tractivity significantly overestimated step count. The Movemonitor was the best performing sensor, with an error lower than 2% at all speeds and the smallest error obtained in the outdoor walking. The activity recognition protocol showed that the Movemonitor performed best in the walking recognition, but had difficulty in discriminating between standing and sitting. Results of this study can be used to inform choice of a monitor for specific applications.

  11. Step Detection and Activity Recognition Accuracy of Seven Physical Activity Monitors

    PubMed Central

    Storm, Fabio A.; Heller, Ben W.; Mazzà, Claudia

    2015-01-01

    The aim of this study was to compare the seven following commercially available activity monitors in terms of step count detection accuracy: Movemonitor (Mc Roberts), Up (Jawbone), One (Fitbit), ActivPAL (PAL Technologies Ltd.), Nike+ Fuelband (Nike Inc.), Tractivity (Kineteks Corp.) and Sensewear Armband Mini (Bodymedia). Sixteen healthy adults consented to take part in the study. The experimental protocol included walking along an indoor straight walkway, descending and ascending 24 steps, free outdoor walking and free indoor walking. These tasks were repeated at three self-selected walking speeds. Angular velocity signals collected at both shanks using two wireless inertial measurement units (OPAL, ADPM Inc) were used as a reference for the step count, computed using previously validated algorithms. Step detection accuracy was assessed using the mean absolute percentage error computed for each sensor. The Movemonitor and the ActivPAL were also tested within a nine-minute activity recognition protocol, during which the participants performed a set of complex tasks. Posture classifications were obtained from the two monitors and expressed as a percentage of the total task duration. The Movemonitor, One, ActivPAL, Nike+ Fuelband and Sensewear Armband Mini underestimated the number of steps in all the observed walking speeds, whereas the Tractivity significantly overestimated step count. The Movemonitor was the best performing sensor, with an error lower than 2% at all speeds and the smallest error obtained in the outdoor walking. The activity recognition protocol showed that the Movemonitor performed best in the walking recognition, but had difficulty in discriminating between standing and sitting. Results of this study can be used to inform choice of a monitor for specific applications. PMID:25789630

  12. Cadence Feedback With ECE PEDO to Monitor Physical Activity Intensity

    PubMed Central

    Ardic, Fusun; Göcer, Esra

    2016-01-01

    Abstract The purpose of this study was to examine the monitoring capabilities of the equipment for clever exercise pedometer (ECE PEDO) that provides audible feedback when the person exceeds the upper and lower limits of the target step numbers per minute and to compare step counts with Yamax SW-200 (YX200) as the criterion pedometer. A total of 30 adult volunteers (15 males and 15 females) were classified as normal weight (n = 10), overweight (n = 10), and obese (n = 10). After the submaximal exercise test on a treadmill, the moderate intensity for walking was determined by using YX200 pedometer and then the number of steps taken in a minute was measured. Lower and upper limits of steps per minute (cadence) were recorded in ECE PEDO providing audible feedback when the person's walking speed gets out of the limits. Volunteers walked for 30 minutes in the individual step count range by attaching the ECE PEDO and YX200 pedometer on both sides of the waist belt in the same session. Step counts of the volunteers were recorded. Wilcoxon, Spearman correlation, and Bland–Altman analyses were performed to show the relationship and agreement between the results of 2 devices. Subjects took an average of 3511 ± 426 and 3493 ± 399 steps during 30 minutes with ECE PEDO and criterion pedometer, respectively. About 3500 steps taken by ECE PEDO reflected that this pedometer has capability of identifying steps per minute to meet moderate intensity of physical activity. There was a strong correlation between step counts of both devices (P < 0.001, r = 0.96). Correlations across all three BMI categories and both sex remained consistently high ranging from 0.92 to 0.95. There was a high level of agreement between the ECE PEDO and YX200 pedometer in the Bland–Altman analysis. Although both devices showed a strong similarity in counting steps, the ECE PEDO provides monitoring of intensity such that a person can walk in a specified time with a

  13. Measurement of activity in older adults: reliability and validity of the Step Activity Monitor.

    PubMed

    Resnick, B; Nahm, E S; Orwig, D; Zimmerman, S S; Magaziner, J

    2001-01-01

    The purpose of this study was to test the reliability and validity of the Step Activity Monitor (SAM) when used with older adults. A total of 30 subjects with a mean age of 86 +/- 6.1 participated in the study. Sixty one-minute walks were measured with the SAM, and two observers visually counted steps. Four participants wore the SAM for 6 to 48 hours and maintained activity diaries. The intraclass correlation for the SAM recordings was R = .84. There was an overall step counting accuracy of 96%. The diaries supported the SAM data for those who wore the SAM for extended periods. The SAM is an easy to use, comfortable, valid, and reliable measure of activity in older adults and particularly may be useful to triangulate measurement of activity in these individuals.

  14. Brucellosis in a renal transplant recipient.

    PubMed

    Ting, I W; Ho, M W; Sung, Y J; Tien, N; Chi, C Y; Ho, H C; Huang, C C

    2013-10-01

    Brucellosis is one of the most common systemic zoonotic diseases transmitted by consumption of unpasteurized dairy products or by occupational contact with infected animals. Brucellosis is rare in renal transplant recipients. Only 3 cases have been reported in the literature. We report a case of brucellosis with hematologic and hepatobiliary complications in a patient 3 years after renal transplantation. The mean time from transplantation to the diagnosis of brucellosis in these 4 reported patients was 5.1 years (range 17 months to 13 years). All patients had fever and constitutional symptoms, and all attained clinical cure after combination antibiotic therapy. Given the small number of patients, further study is needed to identify the characteristics of brucellosis in renal transplant recipients. Drug interactions and acute renal failure developed in our patient during antibiotic treatment. Therefore, we should monitor the levels of immunosuppressive agents frequently. Several studies have shown in vitro susceptibilities of Brucella melitensis to tigecycline. In our patient, fever finally subsided after tigecycline administration. The minimum inhibitory concentration of tigecycline using Etest was 0.094 μg/mL. Tigecycline may be a potential option for treatment of brucellosis in the setting of transplantation.

  15. BK Virus in Recipients of Kidney Transplants.

    PubMed

    Hendrix, Kelly M

    2014-01-01

    Since its discovery in 1971, the BK virus, a human polyomavirus, has emerged as a significant cause of renal dysfunction and transplant graft loss in kidney transplant recipients. Improved screening methods have been effective in assisting in the early identification of the virus, and thus, prompt intervention to prevent the progression of the disease. Treatment options for the virus are limited; therefore, lowering immunosuppressive medications should be considered the first line of treatment. Current adjunctive therapies are not guaranteed to control the viral activity and may have limited therapeutic value.

  16. Behavior Change Techniques Implemented in Electronic Lifestyle Activity Monitors: A Systematic Content Analysis

    PubMed Central

    Lewis, Zakkoyya H; Mayrsohn, Brian G; Rowland, Jennifer L

    2014-01-01

    Background Electronic activity monitors (such as those manufactured by Fitbit, Jawbone, and Nike) improve on standard pedometers by providing automated feedback and interactive behavior change tools via mobile device or personal computer. These monitors are commercially popular and show promise for use in public health interventions. However, little is known about the content of their feedback applications and how individual monitors may differ from one another. Objective The purpose of this study was to describe the behavior change techniques implemented in commercially available electronic activity monitors. Methods Electronic activity monitors (N=13) were systematically identified and tested by 3 trained coders for at least 1 week each. All monitors measured lifestyle physical activity and provided feedback via an app (computer or mobile). Coding was based on a hierarchical list of 93 behavior change techniques. Further coding of potentially effective techniques and adherence to theory-based recommendations were based on findings from meta-analyses and meta-regressions in the research literature. Results All monitors provided tools for self-monitoring, feedback, and environmental change by definition. The next most prevalent techniques (13 out of 13 monitors) were goal-setting and emphasizing discrepancy between current and goal behavior. Review of behavioral goals, social support, social comparison, prompts/cues, rewards, and a focus on past success were found in more than half of the systems. The monitors included a range of 5-10 of 14 total techniques identified from the research literature as potentially effective. Most of the monitors included goal-setting, self-monitoring, and feedback content that closely matched recommendations from social cognitive theory. Conclusions Electronic activity monitors contain a wide range of behavior change techniques typically used in clinical behavioral interventions. Thus, the monitors may represent a medium by which

  17. State monitoring activities related to Pfiesteria-like organisms.

    PubMed

    Magnien, R E

    2001-10-01

    In response to potential threats to human health and fish populations, six states along the east coast of the United States initiated monitoring programs related to Pfiesteria-like organisms in 1998. These actions were taken in the wake of toxic outbreaks of Pfiesteria piscicida Steidinger & Burkholder in Maryland during 1997 and previous outbreaks in North Carolina. The monitoring programs have two major purposes. The first, rapid response, is to ensure public safety by responding immediately to conditions that may indicate the presence of Pfiesteria or related organisms in a toxic state. The second, comprehensive assessment, is to provide a more complete understanding of where Pfiesteria-like organisms may become a threat, to understand what factors may stimulate their growth and toxicity, and to evaluate the impacts of these organisms upon fish and other aquatic life. In states where human health studies are being conducted, the data from both types of monitoring are used to provide information on environmental exposure. The three elements included in each monitoring program are identification of Pfiesteria-like organisms, water quality measurements, and assessments of fish health. Identification of Pfiesteria-like organisms is a particularly difficult element of the monitoring programs, as these small species cannot be definitively identified using light microscopy; newly applied molecular techniques, however, are starting to provide alternatives to traditional methods. State monitoring programs also offer many opportunities for collaborations with research initiatives targeting both environmental and human health issues related to Pfiesteria-like organisms.

  18. State monitoring activities related to Pfiesteria-like organisms.

    PubMed Central

    Magnien, R E

    2001-01-01

    In response to potential threats to human health and fish populations, six states along the east coast of the United States initiated monitoring programs related to Pfiesteria-like organisms in 1998. These actions were taken in the wake of toxic outbreaks of Pfiesteria piscicida Steidinger & Burkholder in Maryland during 1997 and previous outbreaks in North Carolina. The monitoring programs have two major purposes. The first, rapid response, is to ensure public safety by responding immediately to conditions that may indicate the presence of Pfiesteria or related organisms in a toxic state. The second, comprehensive assessment, is to provide a more complete understanding of where Pfiesteria-like organisms may become a threat, to understand what factors may stimulate their growth and toxicity, and to evaluate the impacts of these organisms upon fish and other aquatic life. In states where human health studies are being conducted, the data from both types of monitoring are used to provide information on environmental exposure. The three elements included in each monitoring program are identification of Pfiesteria-like organisms, water quality measurements, and assessments of fish health. Identification of Pfiesteria-like organisms is a particularly difficult element of the monitoring programs, as these small species cannot be definitively identified using light microscopy; newly applied molecular techniques, however, are starting to provide alternatives to traditional methods. State monitoring programs also offer many opportunities for collaborations with research initiatives targeting both environmental and human health issues related to Pfiesteria-like organisms. PMID:11677180

  19. GRID based Thermal Images Processing for volcanic activity monitoring

    NASA Astrophysics Data System (ADS)

    Mangiagli, S.; Coco, S.; Drago, L.; Laudani, A.,; Lodato, L.; Pollicino, G.; Torrisi, O.

    2009-04-01

    Since 2001, the Catania Section of the National Institute of Geophysics and Volcanology (INGV) has been running the video stations recording the volcanic activity of Mount Etna, Stromboli and the Fossa Crater of Vulcano island. The video signals of 11 video cameras (seven operating in the visible band and four in infrared) are sent in real time to INGV Control Centre where they are visualized on monitors and archived on a dedicated NAS storage. The video surveillance of the Sicilian volcanoes, situated near to densely populated areas, helps the volcanologists providing the Civil Protection authorities with updates in real time on the on-going volcanic activity. In particular, five video cameras are operating on Mt. Etna and they record the volcano from the south and east sides 24 hours a day. During emergencies, mobile video stations may also be used to better film the most important phases of the activity. Single shots are published on the Catania Section intranet and internet websites. On June 2006 a A 40 thermal camera was installed in Vulcano La Fossa Crater. The location was in the internal and opposite crater flank (S1), 400 m distant from the fumarole field. The first two-year of data on temperature distribution frequency were recorded with this new methodology of acquisition, and automatically elaborated by software at INGV Catania Section. In fact a dedicated software developed in IDL, denominated Volcano Thermo Analysis (VTA), was appositely developed in order to extract a set of important features, able to characterize with a good approssimation the volcanic activity. In particular the program first load and opportunely convert the thermal images, then according to the Region Of Interest (ROI) and the temperature ranges defined by the user provide to automatic spatial and statistic analysis. In addition the VTA is able to analysis all the temporal series of images available in order to achieve the time-event analysis and the dynamic of the volcanic

  20. EPA Grants Overview for Applicants and Recipients

    EPA Pesticide Factsheets

    The purpose of this training seminar is to ensure that EPA's nonprofit recipient community understands the assistance agreement regulations and EPA's nonprofit recipient community understands how to manage assistance agreements.

  1. 5 CFR 1315.15 - Grant recipients.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Grant recipients. 1315.15 Section 1315.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.15 Grant recipients. Recipients of Federal assistance may pay interest penalties if so specified in their contracts...

  2. 40 CFR 725.420 - Recipient microorganisms.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Recipient microorganisms. 725.420... CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.420 Recipient microorganisms. The following recipient microorganisms are eligible for...

  3. 40 CFR 725.420 - Recipient microorganisms.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Recipient microorganisms. 725.420... CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.420 Recipient microorganisms. The following recipient microorganisms are eligible for...

  4. 40 CFR 725.420 - Recipient microorganisms.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Recipient microorganisms. 725.420... CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.420 Recipient microorganisms. The following recipient microorganisms are eligible for...

  5. 40 CFR 725.420 - Recipient microorganisms.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Recipient microorganisms. 725.420... CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.420 Recipient microorganisms. The following recipient microorganisms are eligible for...

  6. 40 CFR 725.420 - Recipient microorganisms.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Recipient microorganisms. 725.420... CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.420 Recipient microorganisms. The following recipient microorganisms are eligible for...

  7. 34 CFR 84.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Recipient. 84.660 Section 84.660 Education Office of... ASSISTANCE) Definitions § 84.660 Recipient. Recipient means any individual, corporation, partnership... and 3474; and Sec. 2455, Pub. L. 103-355, 108 Stat. 3243 at 3327.)...

  8. 22 CFR 1509.660 - Recipient.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Recipient. 1509.660 Section 1509.660 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.660 Recipient. Recipient means any individual, corporation,...

  9. 22 CFR 1509.660 - Recipient.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Recipient. 1509.660 Section 1509.660 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.660 Recipient. Recipient means any individual, corporation,...

  10. 22 CFR 1509.660 - Recipient.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Recipient. 1509.660 Section 1509.660 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.660 Recipient. Recipient means any individual, corporation,...

  11. 24 CFR 21.660 - Recipient.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Recipient. 21.660 Section 21.660 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.660 Recipient. Recipient means...

  12. 22 CFR 210.660 - Recipient.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Recipient. 210.660 Section 210.660 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 210.660 Recipient. Recipient means any individual,...

  13. 22 CFR 1509.660 - Recipient.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Recipient. 1509.660 Section 1509.660 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.660 Recipient. Recipient means any individual, corporation,...

  14. 5 CFR 1315.15 - Grant recipients.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Grant recipients. 1315.15 Section 1315.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.15 Grant recipients. Recipients of Federal assistance may pay interest penalties if so specified in their contracts...

  15. 5 CFR 1315.15 - Grant recipients.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Grant recipients. 1315.15 Section 1315.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.15 Grant recipients. Recipients of Federal assistance may pay interest penalties if so specified in their contracts...

  16. 5 CFR 1315.15 - Grant recipients.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Grant recipients. 1315.15 Section 1315.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.15 Grant recipients. Recipients of Federal assistance may pay interest penalties if so specified in their contracts...

  17. 5 CFR 1315.15 - Grant recipients.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Grant recipients. 1315.15 Section 1315.15 Administrative Personnel OFFICE OF MANAGEMENT AND BUDGET OMB DIRECTIVES PROMPT PAYMENT § 1315.15 Grant recipients. Recipients of Federal assistance may pay interest penalties if so specified in their contracts...

  18. 22 CFR 1509.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Recipient. 1509.660 Section 1509.660 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 1509.660 Recipient. Recipient means any individual, corporation,...

  19. 24 CFR 21.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Recipient. 21.660 Section 21.660 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 21.660 Recipient. Recipient means...

  20. 22 CFR 210.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recipient. 210.660 Section 210.660 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 210.660 Recipient. Recipient means any individual,...

  1. 22 CFR 312.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Recipient. 312.660 Section 312.660 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.660 Recipient. Recipient means any individual, corporation, partnership, association, unit...

  2. 22 CFR 312.660 - Recipient.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Recipient. 312.660 Section 312.660 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.660 Recipient. Recipient means any individual, corporation, partnership, association, unit...

  3. 22 CFR 312.660 - Recipient.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Recipient. 312.660 Section 312.660 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 312.660 Recipient. Recipient means any individual, corporation, partnership, association, unit...

  4. 28 CFR 83.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Recipient. 83.660 Section 83.660 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Definitions § 83.660 Recipient. Recipient means any individual, corporation, partnership, association, unit...

  5. 10 CFR 603.510 - Recipient qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Recipient qualifications. 603.510 Section 603.510 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.510 Recipient qualifications. Prior to award of a TIA,...

  6. 10 CFR 607.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Recipient. 607.660 Section 607.660 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 607.660 Recipient. Recipient means any individual, corporation,...

  7. 31 CFR 20.660 - Recipient.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Recipient. 20.660 Section 20.660 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.660 Recipient. Recipient means any...

  8. 31 CFR 20.660 - Recipient.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Recipient. 20.660 Section 20.660 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.660 Recipient. Recipient means any...

  9. 31 CFR 20.660 - Recipient.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Recipient. 20.660 Section 20.660 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.660 Recipient. Recipient means any...

  10. 31 CFR 20.660 - Recipient.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Recipient. 20.660 Section 20.660 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.660 Recipient. Recipient means any...

  11. 31 CFR 20.660 - Recipient.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Recipient. 20.660 Section 20.660 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 20.660 Recipient. Recipient means any...

  12. Monitoring seismic wave speed by an active seismic source

    NASA Astrophysics Data System (ADS)

    Yokoyama, K.; Kawakata, H.; Doi, I.; Okubo, M.; Saiga, A.

    2012-12-01

    Decreases in elastic wave speed around cracked zones prior to faulting in rock fracture experiments have been reported (e.g., Yukutake, 1989; Yoshimitsu et al., 2009). These decreases in wave speed have been considered to be associated with crack and fault growth based on non-destructive observation using X-ray CT scan (Kawakata et al., 1999). Meanwhile, there were some reports on the decreases in seismic wave speed along paths that cross the hypocentral area in periods including some large earthquakes. Uchida et al. (2002) analyzed seismic waveform with explosive sources before and after the 1998 northern Iwate prefecture earthquake, and they showed that the decrease in seismic wave speed approximately 0.1-0.9 % by the earthquake occurrence. Justin et al. (2007) reported the reduction in seismic wave speed accompanied with the 2003 Tokachi oki earthquake around the rupture area by using the four repeating earthquakes that occurred before and after the 2003 Tokachi oki earthquake. However, seismograms of explosive sources or repeating earthquakes are hard to be frequently recorded, which makes the time intervals of estimated seismic wave speed be too long to distinguish preseismic changes from coseismic and post seismic changes. In order to monitor crustal structures and detecting the variation of rock properties in the crust, a kind of active seismic source systems ACROSS (Accurately Controlled Routinely Operated Signal System) has been developed(e.g., Kunitomo and Kumazawa, 2004). We used the controlled seismic source ACROSS, which installed at the Tono mine, Gifu prefecture, central Japan and has been routinely operated by Tono Geoscience center of JAEA (Japan Atomic Energy Agency), automatically. Frequency modulated seismic waves are continuously radiated from approximately 10-20 Hz by eccentric rotation of the source. In order to investigate the stability of ACROSS signals, we used seismograms recorded at the 110m depth of Shobasama observing site, which is

  13. Embedded Ultrasonic Transducers for Active and Passive Concrete Monitoring

    PubMed Central

    Niederleithinger, Ernst; Wolf, Julia; Mielentz, Frank; Wiggenhauser, Herbert; Pirskawetz, Stephan

    2015-01-01

    Recently developed new transducers for ultrasonic transmission, which can be embedded right into concrete, are now used for non-destructive permanent monitoring of concrete. They can be installed during construction or thereafter. Large volumes of concrete can be monitored for changes of material properties by a limited number of transducers. The transducer design, the main properties as well as installation procedures are presented. It is shown that compressional waves with a central frequency of 62 kHz are mainly generated around the transducer’s axis. The transducer can be used as a transmitter or receiver. Application examples demonstrate that the transducers can be used to monitor concrete conditions parameters (stress, temperature, …) as well as damages in an early state or the detection of acoustic events (e.g., crack opening). Besides application in civil engineering our setups can also be used for model studies in geosciences. PMID:25923928

  14. AMS/DOE Fellowship Recipients

    SciTech Connect

    Armstrong, Stephanie

    2016-11-21

    The AMS/DOE graduate fellowships were awarded to three students entering their first year of graduate study. The funds allowed each student to take a full course load during their first of year of graduate study which helps each of them to enter the professional, scientific community at an earlier date. Each recipient is academically outstanding, received glowing references of support and demonstrated their strong desire to perform scientific research. As part of the fellowship, each of the students was invited to attend the AMS Annual Meeting where they got to participate in the AMS student conference, attend scientific sessions and visit the exhibition hall. In addition, a student awards luncheon was held where each of the recipients got to meet their sponsor and receive a certificate.

  15. When a Step Is Not a Step! Specificity Analysis of Five Physical Activity Monitors

    PubMed Central

    O’Connell, Sandra; ÓLaighin, Gearóid

    2017-01-01

    Introduction Physical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important that activity-monitoring devices be both sensitive and specific in recording actual steps taken and disregard non-stepping body movements. The objective of this study was to assess the specificity of five activity monitors during a variety of prescribed non-stepping activities. Methods Participants wore five activity monitors simultaneously for a variety of prescribed activities including deskwork, taking an elevator, taking a bus journey, automobile driving, washing and drying dishes; functional reaching task; indoor cycling; outdoor cycling; and indoor rowing. Each task was carried out for either a specific duration of time or over a specific distance. Activity monitors tested were the ActivPAL micro™, NL-2000™ pedometer, Withings Smart Activity Monitor Tracker (Pulse O2)™, Fitbit One™ and Jawbone UP™. Participants were video-recorded while carrying out the prescribed activities and the false positive step count registered on each activity monitor was obtained and compared to the video. Results All activity monitors registered a significant number of false positive steps per minute during one or more of the prescribed activities. The Withings™ activity performed best, registering a significant number of false positive steps per minute during the outdoor cycling activity only (P = 0.025). The Jawbone™ registered a significant number of false positive steps during the functional reaching task and while washing and drying dishes, which involved arm and hand movement (P < 0.01 for both). The ActivPAL™ registered a significant number of false positive steps during the cycling exercises (P < 0.001 for both). Conclusion As a number of false positive steps were registered on the activity monitors during the non-stepping activities, the

  16. Relationship between balance and physical activity measured by an activity monitor in elderly COPD patients

    PubMed Central

    Iwakura, Masahiro; Okura, Kazuki; Shibata, Kazuyuki; Kawagoshi, Atsuyoshi; Sugawara, Keiyu; Takahashi, Hitomi; Shioya, Takanobu

    2016-01-01

    Background Little is known regarding the relationship between balance impairments and physical activity in COPD. There has been no study investigating the relationship between balance and objectively measured physical activity. Here we investigated the association between balance and physical activity measured by an activity monitor in elderly COPD patients. Materials and methods Twenty-two outpatients with COPD (mean age, 72±7 years; forced expiratory volume in 1 second, 53%±21% predicted) and 13 age-matched healthy control subjects (mean age, 72±6 years) participated in the study. We assessed all 35 subjects’ balance (one-leg standing test [OLST] times, Short Physical Performance Battery total scores, standing balance test scores, 4 m gait speed, and five-times sit-to-stand test [5STST]) and physical activity (daily steps and time spent in moderate-to-vigorous physical activity per day [MV-PA]). Possible confounders were assessed in the COPD group. The between-group differences in balance test scores and physical activity were analyzed. A correlation analysis and multivariate regression analysis were conducted in the COPD group. Results The COPD patients exhibited significant reductions in OLST times (P=0.033), Short Physical Performance Battery scores (P=0.013), 4 m gait speed (P<0.001), five-times sit-to-stand times (P=0.002), daily steps (P=0.003), and MV-PA (P=0.022) compared to the controls; the exception was the standing balance test scores. The correlation and multivariate regression analyses revealed significant independent associations between OLST times and daily steps (P<0.001) and between OLST times and MV-PA (P=0.014) in the COPD group after adjusting for possible confounding factors. Conclusion Impairments in balance and reductions in physical activity were observed in the COPD group. Deficits in balance are independently associated with physical inactivity. PMID:27445470

  17. Monitoring

    SciTech Connect

    Orr, Christopher Henry; Luff, Craig Janson; Dockray, Thomas; Macarthur, Duncan Whittemore

    2004-11-23

    The invention provides apparatus and methods which facilitate movement of an instrument relative to an item or location being monitored and/or the item or location relative to the instrument, whilst successfully excluding extraneous ions from the detection location. Thus, ions generated by emissions from the item or location can successfully be monitored during movement. The technique employs sealing to exclude such ions, for instance, through an electro-field which attracts and discharges the ions prior to their entering the detecting location and/or using a magnetic field configured to repel the ions away from the detecting location.

  18. Occupations of SSI recipients who work.

    PubMed

    Hemmeter, Jeffrey

    2009-01-01

    This article uses the 2007 American Community Survey to estimate the occupational distribution of Supplemental Security Income (SSI) disability recipients aged 18-61 who work, and it compares their occupational distribution with that of working nonrecipients with and without disabilities. Based on models of occupational choice for working SSI recipients and nonrecipients, predicted occupational distributions are also estimated to understand what occupations are available to SSI recipients. Unlike the nonrecipient populations that are largely composed of sales- and office-based occupations (25 percent), the most common occupations of SSI recipients who work are in services (34 percent) and production, transportation, and material moving (30 percent), although sales- and office-based occupations are also common for SSI recipients (22 percent). The occupational distribution of working SSI recipients is also more concentrated than that of nonrecipient populations. Dissimilarity indices are used to compare the predicted and actual occupational distributions of the SSI recipient population and nonrecipient populations. More than one-half of the difference between the occupations of working SSI recipients and nonrecipients can be explained by demographic characteristics, human capital, and disability type. Additionally, nonemployed SSI recipients have similar predicted occupational distributions as currently employed SSI recipients. Given the estimated occupational distributions and the average earnings of individuals in the most common occupations of SSI recipients, the results suggest that more targeted vocational training may provide expanded opportunities for employment.

  19. Monitoring of acoustic emission activity using thin wafer piezoelectric sensors

    NASA Astrophysics Data System (ADS)

    Trujillo, Blaine; Zagrai, Andrei; Meisner, Daniel; Momeni, Sepand

    2014-03-01

    Acoustic emission (AE) is a well-known technique for monitoring onset and propagation of material damage. The technique has demonstrated utility in assessment of metallic and composite materials in applications ranging from civil structures to aerospace vehicles. While over the course of few decades AE hardware has changed dramatically with the sensors experiencing little changes. A traditional acoustic emission sensor solution utilizes a thickness resonance of the internal piezoelectric element which, coupled with internal amplification circuit, results in relatively large sensor footprint. Thin wafer piezoelectric sensors are small and unobtrusive, but they have seen limited AE applications due to low signal-to-noise ratio and other operation difficulties. In this contribution, issues and possible solutions pertaining to the utility of thin wafer piezoelectrics as AE sensors are discussed. Results of AE monitoring of fatigue damage using thin wafer piezoelectric and conventional AE sensors are presented.

  20. Energy monitoring based on human activity in the workplace

    NASA Astrophysics Data System (ADS)

    Mustafa, N. H.; Husain, M. N.; Abd Aziz, M. Z. A.; Othman, M. A.; Malek, F.

    2014-04-01

    Human behavior is the most important factor in order to manage energy usage. Nowadays, smart house technology offers a better quality of life by introducing automated appliance control and assistive services. However, human behaviors will contribute to the efficiency of the system. This paper will focus on monitoring efficiency based on duration time in office hours around 8am until 5pm which depend on human behavior atb the workplace. Then, the correlation coefficient method is used to show the relation between energy consumption and energy saving based on the total hours of time energy spent. In future, the percentages of energy monitoring system usage will be increase to manage energy in efficient ways based on human behaviours. This scenario will lead to the positive impact in order to achieve the energy saving in the building and support the green environment.

  1. A mobile system for active otpical pollution monitoring

    NASA Technical Reports Server (NTRS)

    Sunesson, A.; Edner, H.; Svanberg, S.; Uneus, L.; Wendt, W.; Fredriksson, K.

    1986-01-01

    The remote monitoring of atmospheric pollutants can now be performed in several ways. Laser radar techniques have proven their ability to reveal the spatial distribution of different species or particles. Classical optical techniques can also be used, but yield the average concentration over a given path and hence no range resolution. One such technique is Differential Optical Absorption Spectroscopy, DOAS. Such schemes can be used to monitor paths that a preliminary lidar investigation has shown to be of interest. Having previously had access to a mobile lidar system, a new system has been completed. The construction builds on experience from using the other system and it is meant to be more of a mobile optical laboratory than just a lidar system. A complete system description is given along with some preliminary usage. Future uses are contemplated.

  2. Cable condition monitoring research activities at Sandia National Laboratories

    SciTech Connect

    Jacobus, M.J.; Zigler, G.L.; Bustard, L.D.

    1988-01-01

    Sandia National Laboratories is currently conducting long-term aging research on representative samples of nuclear power plant cables. The objectives of the program are to determine the suitability of these cables for extended life (beyond 40 year design basis) and to assess various cable condition monitoring techniques for predicting remaining cable life. The cables are being aged for long times at relatively mild exposure conditions with various condition monitoring techniques to be employed during the aging process. Following the aging process, the cables will be exposed to a sequential accident profile consisting of high dose rate irradiation followed by a simulated design basis loss-of-coolant accident (LOCA) steam exposure. 12 refs., 1 fig., 1 tab.

  3. Active subjects of passive monitoring: responses to a passive monitoring system in low-income independent living

    PubMed Central

    BERRIDGE, CLARA

    2016-01-01

    Passive monitoring technology is beginning to be reimbursed by third-party payers in the United States of America. Given the low voluntary uptake of these technologies on the market, it is important to understand the concerns and perspectives of users, former users and non-users. In this paper, the range of ways older adults relate to passive monitoring in low-income independent-living residences is presented. This includes experiences of adoption, non-adoption, discontinuation and creative ‘misuse’. The analysis of interviews reveals three key insights. First, assumptions built into the technology about how older adults live present a problem for many users who experience unwanted disruptions and threats to their behavioural autonomy. Second, resident response is varied and challenges the dominant image of residents as passive subjects of a passive monitoring system. Third, the priorities of older adults (e.g. safety, autonomy, privacy, control, contact) are more diverse and multi-faceted than those of the housing organisation staff and family members (e.g. safety, efficiency) who drive the passive monitoring intervention. The tension between needs, desires and the daily lives of older adults and the technological solutions offered to them is made visible by their active responses, including resistance to them. This exposes the active and meaningful qualities of older adults’ decisions and practices. PMID:28239211

  4. Active subjects of passive monitoring: responses to a passive monitoring system in low-income independent living.

    PubMed

    Berridge, Clara

    2017-03-01

    Passive monitoring technology is beginning to be reimbursed by third-party payers in the United States of America. Given the low voluntary uptake of these technologies on the market, it is important to understand the concerns and perspectives of users, former users and non-users. In this paper, the range of ways older adults relate to passive monitoring in low-income independent-living residences is presented. This includes experiences of adoption, non-adoption, discontinuation and creative 'misuse'. The analysis of interviews reveals three key insights. First, assumptions built into the technology about how older adults live present a problem for many users who experience unwanted disruptions and threats to their behavioural autonomy. Second, resident response is varied and challenges the dominant image of residents as passive subjects of a passive monitoring system. Third, the priorities of older adults (e.g. safety, autonomy, privacy, control, contact) are more diverse and multi-faceted than those of the housing organisation staff and family members (e.g. safety, efficiency) who drive the passive monitoring intervention. The tension between needs, desires and the daily lives of older adults and the technological solutions offered to them is made visible by their active responses, including resistance to them. This exposes the active and meaningful qualities of older adults' decisions and practices.

  5. Hearing Dogs: A Longitudinal Study of Social and Psychological Effects on Deaf and Hard-of-Hearing Recipients

    ERIC Educational Resources Information Center

    Guest, Claire M.; Collis, Glyn M.; McNicholas, June

    2006-01-01

    The organization Hearing Dogs for Deaf People provides assistance dogs that alert their deaf or hard-of-hearing recipients to key sounds, thus increasing their independence and also providing companionship. Fifty-one recipients took part in a longitudinal study to monitor the dogs' working performance over time and to examine the social and…

  6. FRET-Based Optical Assay for Monitoring Riboswitch Activation

    DTIC Science & Technology

    2009-04-09

    including small organic molecules, peptides, and aminoglycosides among others. 10 The advantage of such engineered riboswitches is that they offer a way...Laboratory, Dayton, OH. ‡ USAMRMC, Fort Detrick, MD. Biomacromolecules 2009, 10 , 1055–1060 1055 10.1021/bm801117f CCC: $40.75  2009 American Chemical...SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10 . SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION

  7. Activity Monitors Help Users Get Optimum Sun Exposure

    NASA Technical Reports Server (NTRS)

    2015-01-01

    Goddard scientist Shahid Aslam was investigating alternative methods for measuring extreme ultraviolet radiation on the Solar Dynamics Observatory when he hit upon semiconductors that measured wavelengths pertinent to human health. As a result, he and a partner established College Park, Maryland-based Sensor Sensor LLC and developed UVA+B SunFriend, a wrist monitor that lets people know when they've received their optimal amounts of sunlight for the day.

  8. Life experiences in heart transplant recipients

    PubMed Central

    Monemian, Sharifeh; Abedi, Heidarali; Naji, Saied Ali

    2015-01-01

    Introduction: Heart transplantation is considered as a golden standard of treatment for advanced heart failure. After - transplantation health of patients is influenced by numerous issues which many of them are unknown to the treatment team including nurses. This research - with the aim of describing the life experiences of heart transplant patients - help us to get close to the patients private life and gain comprehensive and a general understanding of all aspects of their life. Methods: This study applied qualitative approach using phenomenology method. The purposive sampling was conducted and continued with 9 participants until information reached saturation point. The participants are the heart transplant recipients who had surgery in Esfahan's Heart Surgery Center of Shahid Chamran. Results: The extracted interviews were analyzed through Colaizzi method: The eleven extracted main concepts were included: Belief, tendencies of the recipient and family of donor, bewilderment, moment of facing with transplantation, satisfaction, vital organ, support, temperament, physical effects of transplantation, mental changes, paradox of life and death. Conclusion: In heart transplant patients, being in touch with peers and family support have an important role in putting up with the transplantation issue. Lack of social situation and social support were among the patients distresses. Lack of the necessary information about transplantation made patients dissatisfied with the heart transplantation. Regarding the research findings, training received by patients would not be suffice and lack of information has been made them face with problems; therefore, the nurse team of transplantation should play more an active role in training the patients. PMID:25861663

  9. 30 CFR 280.29 - Will MMS monitor the environmental effects of my activity?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Obligations Under This Part Environmental Issues § 280.29 Will MMS monitor the environmental effects of my... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Will MMS monitor the environmental effects of my activity? 280.29 Section 280.29 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF...

  10. Urolithiasis in renal transplant donors and recipients: An update.

    PubMed

    Harraz, Ahmed M; Kamal, Ahmed I; Shokeir, Ahmed A

    2016-12-01

    Urolithiasis in the context of renal transplant is a quite rare event that requires keeping a higher index of suspicion and vigilance. Donors with incidentally discovered asymptomatic renal stones "donor gifted lithiasis" are potentially considered for donation should they are not recurrent stone formers and in the absence of active biochemical disorders. Stone clearance from the donors can be done before donation using shock wave lithotripsy and/or flexible ureteroscopy. Ex vivo ureteroscopy at time of transplant is equally feasible and safe. A variety of anatomical, metabolic and surgical factors contribute to de novo lithiasis after transplantation. Diagnosis is challenging as the transplanted kidney is denervated and the presentation is consequently, atypical. Endourological armamentarium is readily present within the hands of the urologists for adequately addressing the stones and including shock wave lithotripsy, percutaneous nephrolithotomy and flexible ureteroscopy. Whilst all endourological techniques have proven feasibility and safety, they are surgically demanding and requiring high-volume expertise to be adequately performed. The longterm outcome in terms of stone recurrence or the effect on graft survival is favorable. Finally, formidable counselling as well as postoperative monitoring for both donors and recipients is crucial to minimize urolithiasis-related morbidity.

  11. From Recipients to Partners: Children in Malaria Education in Uganda

    ERIC Educational Resources Information Center

    Nakiwala, Aisha Sembatya

    2016-01-01

    Purpose: Health education that integrates community participation is essential for malaria control. However, children's participation is not generally as active as that of adults, thus turning children into recipients, as opposed to partners in malaria control. The purpose of this paper is to develop a better understanding of how children can…

  12. Sender and Recipient Special Discourse Characteristics in Teaching Translation

    ERIC Educational Resources Information Center

    Gavrilenko, Nataliya N.

    2016-01-01

    Integrative model of special translation training considers the understanding of a foreign text as the key stage of the given activity, which is to large extent stipulated by characteristics of both the source text sender and the translation text recipient. Interdisciplinary approach permitted to involve maximum number of determining factors to…

  13. Active monitoring as cognitive control of grinders design

    NASA Astrophysics Data System (ADS)

    Flizikowski, Jozef B.; Mrozinski, Adam; Tomporowski, Andrzej

    2017-03-01

    A general monitoring methodology applicable to plastics recyclates grinding processes development for energy engineering, has been presented in this work. The method includes two beings: mathematical aiding an invention and working of a novelty. The common set is composed of characteristics, structure, relationships of knowledge about states and transformations, effectiveness and progress of the devices and machinery engineering, e.g. breaking up in the energy-materials recycling process. This innovations theory is identified by the valuation, estimation, testing and creative archiving the elaborated character and structure of the invention and grinders construction development.

  14. Physical Activity Monitoring in Extremely Obese Adolescents from the Teen-LABS Study

    PubMed Central

    Jeffries, Renee M.; Inge, Thomas H.; Jenkins, Todd M; King, Wendy; Oruc, Vedran; Douglas, Andrew D.

    2016-01-01

    Background The accuracy of physical activity (PA) monitors to discriminate between PA, sedentary behavior, and non-wear in extremely obese (EO) adolescents is unknown. Methods Twenty-five subjects (9 male/16 female; age=16.5±2.0 y; BMI=51±8 kg/m2) wore three activity monitors (StepWatch [SAM], Actical [AC], Actiheart [AH]) during a 400 meter walk test (400MWT), two standardized PA bouts of varying duration, and one sedentary bout. Results For the 400MWT, percent error between observed and monitor recorded steps was 5.5±7.1% and 82.1±38.6% for the SAM and AC steps, respectively (observed vs. SAM steps: −17.2±22.2 steps; observed vs. AC steps: −264.5±124.8 steps). All activity monitors were able to differentiate between PA and sedentary bouts but only SAM steps and AH heart rate were significantly different between sedentary behavior and non-wear (p<0.001). For all monitors, sedentary behavior was characterized by bouts of zero steps/counts punctuated by intermittent activity steps/counts; non-wear was represented almost exclusively by zero steps/counts. Conclusion Of all monitors tested, the SAM was most accurate in terms of counting steps and differentiating levels of PA, and thus, most appropriate for EO adolescents. The ability to accurately characterize PA intensity in EO adolescents critically depends on activity monitor selection. PMID:25205688

  15. Monitoring Activity of Taking Medicine by Incorporating RFID and Video Analysis

    PubMed Central

    Hasanuzzaman, Faiz M.; Yang, Xiaodong; Tian, YingLi; Liu, Qingshan; Capezuti, Elizabeth

    2013-01-01

    In this paper, we present a new framework to monitor medication intake for elderly individuals by incorporating a video camera and Radio Frequency Identification (RFID) sensors. The proposed framework can provide a key function for monitoring activities of daily living (ADLs) of elderly people at their own home. In an assistive environment, RFID tags are applied on medicine bottles located in a medicine cabinet so that each medicine bottle will have a unique ID. The description of the medicine data for each tag is manually input to a database. RFID readers will detect if any of these bottles are taken away from the medicine cabinet and identify the tag attached on the medicine bottle. A video camera is installed to continue monitoring the activity of taking medicine by integrating face detection and tracking, mouth detection, background subtraction, and activity detection. The preliminary results demonstrate that 100% detection accuracy for identifying medicine bottles and promising results for monitoring activity of taking medicine. PMID:23914344

  16. Active Ground Optical Remote Sensing for Improved Monitoring of Seedling Stress in Nurseries

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Active ground optical remote sensing (AGORS) devices mounted on overhead irrigation booms could help to improve seedling quality by autonomously monitoring seedling stress. In contrast to traditionally used passive optical sensors, AGORS devices operate independently of ambient light conditions and ...

  17. Nanosensor system for monitoring brain activity and drowsiness

    NASA Astrophysics Data System (ADS)

    Ramasamy, Mouli; Varadan, Vijay K.; Harbaugh, Robert

    2015-04-01

    Detection of drowsiness in drivers to avoid on-road collisions and accidents is one of the most important applications that can be implemented to avert loss of life and property caused by accidents. A statistical report indicates that drowsy driving is equally harmful as driving under influence of alcohol. This report also indicates that drowsy driving is the third most influencing factor for accidents and 30% of the commercial vehicle accidents are caused because of drowsy driving. With a motivation to avoid accidents caused by drowsy driving, this paper proposes a technique of correlating EEG and EOG signals to detect drowsiness. Feature extracts of EEG and blink variability from EOG is correlated to detect the sleepiness/drowsiness of a driver. Moreover, to implement a more pragmatic approach towards continuous monitoring, a wireless real time monitoring approach has been incorporated using textile based nanosensors. Thereby, acquired bio potential signals are transmitted through GSM communication module to the receiver continuously. In addition to this, all the incorporated electronics are equipped in a flexible headband which can be worn by the driver. With this flexible headband approach, any intrusiveness that may be experienced by other cumbersome hardware is effectively mitigated. With the continuous transmission of data from the head band, the signals are processed on the receiver side to determine the condition of the driver. Early warning of driver's drowsiness will be displayed in the dashboard of the vehicle as well as alertness voice and sound alarm will be sent via the vehicle radio.

  18. Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site.

    PubMed

    Tamimi, Faleh; Torres, Jesus; Al-Abedalla, Khadijeh; Lopez-Cabarcos, Enrique; Alkhraisat, Mohammad H; Bassett, David C; Gbureck, Uwe; Barralet, Jake E

    2014-07-01

    Onlay grafts made of monolithic microporous monetite bioresorbable bioceramics have the capacity to conduct bone augmentation. However, there is heterogeneity in the graft behaviour in vivo that seems to correlate with the host anatomy. In this study, we sought to investigate the metabolic activity of the regenerated bone in monolithic monetite onlays by using positron emission tomography-computed tomography (PET-CT) in rats. This information was used to optimize the design of monetite onlays with different macroporous architecture that were then fabricated using a 3D-printing technique. In vivo, bone augmentation was attempted with these customized onlays in rabbits. PET-CT findings demonstrated that bone metabolism in the calvarial bone showed higher activity in the inferior and lateral areas of the onlays. Histological observations revealed higher bone volume (up to 47%), less heterogeneity and more implant osseointegration (up to 38%) in the augmented bone with the customized monetite onlays. Our results demonstrated for the first time that it is possible to achieve osseointegration of dental implants in bone augmented with 3D-printed synthetic onlays. It was also observed that designing the macropore geometry according to the bone metabolic activity was a key parameter in increasing the volume of bone augmented within monetite onlays.

  19. Actor-recipient role affects neural responses to self in emotional situations

    PubMed Central

    Wang, Xiaoyan; Zheng, Li; Cheng, Xuemei; Li, Lin; Sun, Lining; Wang, Qianfeng; Guo, Xiuyan

    2015-01-01

    People often take either the role of an actor or that of recipient in positive and negative interpersonal events when they interact with others. The present study investigated how the actor-recipient role affected the neural responses to self in emotional situations. Twenty-five participants were scanned while they were presented with positive and negative interpersonal events and were asked to rate the degree to which the actor/the recipient was that kind of person who caused the interpersonal event. Half of the trials were self-relevant events and the other half were other-relevant events. Results showed that people were more likely to isolate self from negative events when they played the role of actor relative to recipient. Pregenual anterior cingulate cortex (pgACC) and posterior dorsal anterior cingulate cortex (pdACC) were more active for self than other only in negative events. More importantly, also in negative interpersonal events, dorsal medial prefrontal cortex (dmPFC) showed greater self-related activations (self-other) when participants played the role of recipient relative to actor, while activities in orbitofrontal cortex (OFC) were greater for self than other only when the evaluation target played the role of recipient. These results showed that the actor-recipient role affected neural responses to self in emotional situations, especially when a recipient role was played in negative situations. PMID:25926781

  20. Actor-recipient role affects neural responses to self in emotional situations.

    PubMed

    Wang, Xiaoyan; Zheng, Li; Cheng, Xuemei; Li, Lin; Sun, Lining; Wang, Qianfeng; Guo, Xiuyan

    2015-01-01

    People often take either the role of an actor or that of recipient in positive and negative interpersonal events when they interact with others. The present study investigated how the actor-recipient role affected the neural responses to self in emotional situations. Twenty-five participants were scanned while they were presented with positive and negative interpersonal events and were asked to rate the degree to which the actor/the recipient was that kind of person who caused the interpersonal event. Half of the trials were self-relevant events and the other half were other-relevant events. Results showed that people were more likely to isolate self from negative events when they played the role of actor relative to recipient. Pregenual anterior cingulate cortex (pgACC) and posterior dorsal anterior cingulate cortex (pdACC) were more active for self than other only in negative events. More importantly, also in negative interpersonal events, dorsal medial prefrontal cortex (dmPFC) showed greater self-related activations (self-other) when participants played the role of recipient relative to actor, while activities in orbitofrontal cortex (OFC) were greater for self than other only when the evaluation target played the role of recipient. These results showed that the actor-recipient role affected neural responses to self in emotional situations, especially when a recipient role was played in negative situations.

  1. 40 CFR 60.1330 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... activated carbon? 60.1330 Section 60.1330 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1330 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, you must meet...

  2. 40 CFR 60.1330 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... activated carbon? 60.1330 Section 60.1330 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1330 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, you must meet...

  3. 40 CFR 60.1330 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... activated carbon? 60.1330 Section 60.1330 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1330 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, you must meet...

  4. 40 CFR 60.1330 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... activated carbon? 60.1330 Section 60.1330 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1330 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, you must meet...

  5. 40 CFR 60.1330 - How do I monitor the injection rate of activated carbon?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... activated carbon? 60.1330 Section 60.1330 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Requirements § 60.1330 How do I monitor the injection rate of activated carbon? If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, you must meet...

  6. Probes to monitor activity of the paracaspase MALT1.

    PubMed

    Hachmann, Janna; Edgington-Mitchell, Laura E; Poreba, Marcin; Sanman, Laura E; Drag, Marcin; Bogyo, Matthew; Salvesen, Guy S

    2015-01-22

    The human paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) plays a central role in nuclear factor-κB (NF-κB) signaling as both a protease and scaffolding protein. Knocking out MALT1 leads to impaired NF-κB signaling and failure to mount an effective immune response. However, it is unclear to which degree it is the scaffolding function versus the proteolytic activity of MALT1 that is essential. Previous work involving a MALT1 inhibitor with low selectivity suggests that the enzymatic function plays an important role in different cell lines. To help elucidate this proteolytic role of MALT1, we have designed activity-based probes that inhibit its proteolytic activity. The probes selectively label active enzyme and can be used to inhibit MALT1 and trace its activity profile, helping to create a better picture of the significance of the proteolytic function of MALT1.

  7. A portable multi-channel wireless NIRS device for muscle activity real-time monitoring.

    PubMed

    Yao, Pengfei; Guo, Weichao; Sheng, Xinjun; Zhang, Dingguo; Zhu, Xiangyang

    2014-01-01

    Near-infrared spectroscopy (NIRS) is a relative new technology in monitoring muscle oxygenation and hemo-dynamics. This paper presents a portable multi-channel wireless NIRS device for real-time monitoring of muscle activity. The NIRS sensor is designed miniaturized and modularized, to make multi-site monitoring convenient. Wireless communication is applied to data transmission avoiding of cumbersome wires and the whole system is highly integrated. Special care is taken to eliminate motion artifact when designing the NIRS sensor and attaching it to human skin. Besides, the system is designed with high sampling rate so as to monitor rapid oxygenation changes during muscle activities. Dark noise and long-term drift tests have been carried out, and the result indicates the device has a good performance of accuracy and stability. In vivo experiments including arterial occlusion and isometric voluntary forearm muscle contraction were performed, demonstrating the system has the ability to monitor muscle oxygenation parameters effectively even in exercise.

  8. Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model.

    PubMed

    Mondesert, Odile; Frongia, Céline; Clayton, Olivia; Boizeau, Marie-Laure; Lobjois, Valérie; Ducommun, Bernard

    2015-01-01

    Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation. Herein we present DDR-Act-FP, a fluorescent biosensor that allows detection of DDR activation through monitoring of the p21 promoter p53-dependent activation. We show that cells expressing the DDR-Act-FP biosensor efficiently report activation of the DDR pathway after DNA damage and its pharmacological manipulation using ATM kinase inhibitors. We also report the successful use of this assay to screen a small compound library in order to identify activators of the DDR response. Finally, using multicellular spheroids expressing the DDR-Act-FP we demonstrate that DDR activation and its pharmacological manipulation with inhibitory and activatory compounds can be efficiently monitored in live 3D spheroid model. This study paves the way for the development of innovative screening and preclinical evaluation assays.

  9. Seismic activity monitoring in the Izvorul Muntelui dam region

    NASA Astrophysics Data System (ADS)

    Borleanu, Felix; Otilia Placinta, Anca; Popa, Mihaela; Adelin Moldovan, Iren; Popescu, Emilia

    2016-04-01

    Earthquakes occurrences near the artificial water reservoirs are caused by stress variation due to the weight of water, weakness of fractures or faults and increasing of pore pressure in crustal rocks. In the present study we aim to investigate how Izvorul Muntelui dam, located in the Eastern Carpathians influences local seismicity. For this purpose we selected from the seismic bulletins computed within National Data Center of National Institute for Earth Physics, Romania, crustal events occurred between 984 and 2015 in a range of 0.3 deg around the artificial lake. Subsequently to improve the seismic monitoring of the region we applied a cross-correlation detector on the continuous recordings of Bicaz (BIZ) seismic stations. Besides the tectonic events we detected sources within this region that periodically generate artificial evens. We couldn't emphasize the existence of a direct correlation between the water level variations and natural seismicity of the investigated area.

  10. Fluorescence-Based Sensor for Monitoring Activation of Lunar Dust

    NASA Technical Reports Server (NTRS)

    Wallace, William T.; Jeevarajan, Antony S.

    2012-01-01

    This sensor unit is designed to determine the level of activation of lunar dust or simulant particles using a fluorescent technique. Activation of the surface of a lunar soil sample (for instance, through grinding) should produce a freshly fractured surface. When these reactive surfaces interact with oxygen and water, they produce hydroxyl radicals. These radicals will react with a terephthalate diluted in the aqueous medium to form 2-hydroxyterephthalate. The fluorescence produced by 2-hydroxyterephthalate provides qualitative proof of the activation of the sample. Using a calibration curve produced by synthesized 2-hydroxyterephthalate, the amount of hydroxyl radicals produced as a function of sample concentration can also be determined.

  11. Monitoring the activity of the Be star OT Geminorum

    NASA Astrophysics Data System (ADS)

    Arellano Ferro, A.; Sareyan, J. P.; Avila, J. J.; Gonzalez, F.; Dumont, M.; Geos

    1998-02-01

    Observations obtained in 1995-1996 of the Be star OT Geminorum are reported and show that in october 1995 the star reached a very active phase with large variations around a bright plateau, a phase of activity we have also distinguished in previous observations dating from 1960. The time scales involved are discussed and suggest that the violent variations of the activity propagate very quickly on the whole surface of the star or on a huge portion of it. No likely pulsation periods were found. The assumption that the detected activity is due to the effects of an hypothetical companion leads to conclude that such companion could not be detected by the present interferometric techniques. Partly based on observations obtained at the La Luz Observatory of the University of Guanajuato, Mexico.

  12. Monitoring Brain Activity with Protein Voltage and Calcium Sensors

    PubMed Central

    Storace, Douglas A.; Braubach, Oliver R.; Jin, Lei; Cohen, Lawrence B.; Sung, Uhna

    2015-01-01

    Understanding the roles of different cell types in the behaviors generated by neural circuits requires protein indicators that report neural activity with high spatio-temporal resolution. Genetically encoded fluorescent protein (FP) voltage sensors, which optically report the electrical activity in distinct cell populations, are, in principle, ideal candidates. Here we demonstrate that the FP voltage sensor ArcLight reports odor-evoked electrical activity in the in vivo mammalian olfactory bulb in single trials using both wide-field and 2-photon imaging. ArcLight resolved fast odorant-responses in individual glomeruli, and distributed odorant responses across a population of glomeruli. Comparisons between ArcLight and the protein calcium sensors GCaMP3 and GCaMP6f revealed that ArcLight had faster temporal kinetics that more clearly distinguished activity elicited by individual odorant inspirations. In contrast, the signals from both GCaMPs were a saturating integral of activity that returned relatively slowly to the baseline. ArcLight enables optical electrophysiology of mammalian neuronal population activity in vivo. PMID:25970202

  13. Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia.

    PubMed

    Subramaniam, Karuna; Luks, Tracy L; Fisher, Melissa; Simpson, Gregory V; Nagarajan, Srikantan; Vinogradov, Sophia

    2012-02-23

    Schizophrenia patients suffer from severe cognitive deficits, such as impaired reality monitoring. Reality monitoring is the ability to distinguish the source of internal experiences from outside reality. During reality monitoring tasks, schizophrenia patients make errors identifying "I made it up" items, and even during accurate performance, they show abnormally low activation of the medial prefrontal cortex (mPFC), a region that supports self-referential cognition. We administered 80 hr of computerized training of cognitive processes to schizophrenia patients and found improvement in reality monitoring that correlated with increased mPFC activity. In contrast, patients in a computer games control condition did not show any behavioral or neural improvements. Notably, recovery in mPFC activity after training was associated with improved social functioning 6 months later. These findings demonstrate that a serious behavioral deficit in schizophrenia, and its underlying neural dysfunction, can be improved by well-designed computerized cognitive training, resulting in better quality of life.

  14. Monitoring leptin activity using the chicken leptin receptor.

    PubMed

    Hen, Gideon; Yosefi, Sera; Ronin, Ana; Einat, Paz; Rosenblum, Charles I; Denver, Robert J; Friedman-Einat, Miriam

    2008-05-01

    We report on the construction of a leptin bioassay based on the activation of chicken leptin receptor in cultured cells. A human embryonic kidney (HEK)-293 cell line, stably transfected with the full-length cDNA of chicken leptin receptor together with a STAT3-responsive reporter gene specifically responded to recombinant human and Xenopus leptins. The observed higher sensitivity of chicken leptin receptor to the former is in agreement with the degree of sequence similarity among these species (about 60 and 38% identical amino acids between humans and chickens, and between humans and Xenopus respectively). The specific activation of signal transduction through the chicken leptin receptor, shown here for the first time, suggests that the transition of Gln269 (implicated in the Gln-to-Pro Zucker fatty mutation in rats) to Glu in chickens does not impair its activity. Analysis of leptin-like activity in human serum samples of obese and lean subjects coincided well with leptin levels determined by RIA. Serum samples of pre- and post partum cows showed a tight correlation with the degree of adiposity. However, specific activation of the chicken leptin receptor in this assay was not observed with serum samples from broiler or layer chickens (representing fat and lean phenotypes respectively) or with those from turkey. Similar leptin receptor activation profiles were observed with cells transfected with human leptin receptor. Further work is needed to determine whether the lack of leptin-like activity in the chicken serum samples is due to a lack of leptin in this species or simply to a serum level of leptin that is below the detection threshold.

  15. Environmental Protection Agency Award Recipient Responsibilities

    EPA Pesticide Factsheets

    Itemized Award Phase information. Information about the Recipient's Responsibilities Upon Notification of the Award, The EPA Project Officer Responsibilities, and EPA Grant Specialists Responsibilities.

  16. 7 CFR 621.14 - Recipient responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 621.14 Recipient responsibility. Leadership in arrangements for other needed Federal, State, and local... NRCS policy and procedures, the requesting agency has leadership responsibility for developing...

  17. 7 CFR 621.14 - Recipient responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... § 621.14 Recipient responsibility. Leadership in arrangements for other needed Federal, State, and local... NRCS policy and procedures, the requesting agency has leadership responsibility for developing...

  18. Detection of Donor-Derived Microparticles in the Peripheral Blood of a Hand Transplant Recipient During Rejection

    PubMed Central

    Kim, Joseph Y.; Kelesidis, Theodoros; Yang, Otto O.

    2017-01-01

    Background Microparticles (MPs) are released from the plasma membrane of activated or dying cells and bear surface molecules from those cells. We examined whether donor-derived MPs in the peripheral blood of the recipient could serve as a marker of tissue damage due to rejection of a transplanted hand. Methods Platelet-free plasma from the recipient of the transplanted hand was analyzed for MPs bearing the donor-specific HLA molecule A*02 using flow cytometry. Rejection status of the transplanted hand was monitored by histopathology of skin punch biopsies. Results Donor-specific MPs expressing HLA A*02 were quantifiable in the peripheral blood of the recipient. Levels of these MPs increased with worsening rejection of the transplanted hand. Conclusions These findings demonstrate the ability to detect donor specific MPs through staining of graft cell-specific HLA and promote further investigation into the potential utility of flow cytometry for donor-derived MPs as a noninvasive tool to assess rejection in solid organ transplantation patients.

  19. Subsidence monitoring network: an Italian example aimed at a sustainable hydrocarbon E&P activity

    NASA Astrophysics Data System (ADS)

    Dacome, M. C.; Miandro, R.; Vettorel, M.; Roncari, G.

    2015-11-01

    According to the Italian law in order to start-up any new hydrocarbon exploitation activity, an Environmental Impact Assessment study has to be presented, including a monitoring plan, addressed to foresee, measure and analyze in real time any possible impact of the project on the coastal areas and on those ones in the close inland located. The occurrence of subsidence, that could partly be related to hydrocarbon production, both on-shore and off-shore, can generate great concern in those areas where its occurrence may have impacts on the local environment. ENI, following the international scientific community recommendations on the matter, since the beginning of 90's years, implemented a cutting-edge monitoring network, with the aim to prevent, mitigate and control geodynamics phenomena generated in the activity areas, with a particular attention to conservation and protection of environmental and territorial equilibrium, taking care of what is known as "sustainable development". The current ENI implemented monitoring surveys can be divided as: - Shallow monitoring: spirit levelling surveys, continuous GPS surveys in permanent stations, SAR surveys, assestimeter subsurface compaction monitoring, ground water level monitoring, LiDAR surveys, bathymetrical surveys. - Deep monitoring: reservoir deep compaction trough radioactive markers, reservoir static (bottom hole) pressure monitoring. All the information, gathered through the monitoring network, allow: 1. to verify if the produced subsidence is evolving accordingly with the simulated forecast. 2. to provide data to revise and adjust the prediction compaction models 3. to put in place the remedial actions if the impact exceeds the threshold magnitude originally agreed among the involved parties. ENI monitoring plan to measure and monitor the subsidence process, during field production and also after the field closure, is therefore intended to support a sustainable field development and an acceptable exploitation

  20. Smolt Monitoring Activities at Little Goose Dam; 1996 Annual Report.

    SciTech Connect

    Setter, Ann

    1997-07-01

    The juvenile fish facility at Little Goose Dam is operated seasonally to collect and bypass downstream migrating smolts and keep them from passing through the turbine blades. Fish are diverted from turbines by traveling screens as they sound in the forebay to pass the dam. A small percentage of the passing fish are sampled on a daily basis to provide information on fish condition, species composition, migration timing, and size distribution. Oregon Department of Fish and Wildlife personnel perform daily fish sampling and data collection. Physical operation of the facility is the responsibility of the US Army Corps of Engineers. Data is reported to the Fish Passage Center daily by means of electronic data transfer. Funding for this project was provided through the Smolt Monitoring Program administered by the Fish Passage Center. Overall, the number of fish collected and sampled in 1996 was a reduction from the previous years of operation. The 1996 migration season was characterized by higher than average flows and greater spill frequency at the dam. It was the first year that coho salmon were obtained in the sample. The predominant species collected was steelhead with hatchery fish outnumbering wild fish by a ratio of 8:1. An increased emphasis was placed on gas bubble trauma examination and a routine, consistent effort was implemented using a protocol established by the Fish Passage Center. The objective of the gas bubble trauma (GBT) examinations was to document the relative incidence of symptoms throughout the migration season.

  1. A review of market monitoring activities at U.S. independent system operators

    SciTech Connect

    Lesieutre, Bernard C.; Goldman, Charles; Bartholomew, Emily

    2004-01-01

    Policymakers have increasingly recognized the structural impediments to effective competition in electricity markets, which has resulted in a renewed emphasis on the need for careful market design and market monitoring in wholesale and retail electricity markets. In this study, we review the market monitoring activities of four Independent System Operators in the United States, focusing on such topics as the organization of an independent market monitoring unit (MMU), the role and value of external market monitors, performance metrics and indices to aid in market analysis, issues associated with access to confidential market data, and market mitigation and investigation authority. There is consensus across the four ISOs that market monitoring must be organizationally independent from market participants and that ISOs should have authority to apply some degree of corrective actions on the market, though scope and implementation differ across the ISOs. Likewise, current practices regarding access to confidential market data by state energy regulators varies somewhat by ISO. Drawing on our interviews and research, we present five examples that illustrate the impact and potential contribution of ISO market monitoring activities to enhance functioning of wholesale electricity markets. We also discuss several key policy and implementation issues that Western state policymakers and regulators should consider as market monitoring activities evolve in the West.

  2. Hemispheric Asymmetries in the Activation and Monitoring of Memory Errors

    ERIC Educational Resources Information Center

    Giammattei, Jeannette; Arndt, Jason

    2012-01-01

    Previous research on the lateralization of memory errors suggests that the right hemisphere's tendency to produce more memory errors than the left hemisphere reflects hemispheric differences in semantic activation. However, all prior research that has examined the lateralization of memory errors has used self-paced recognition judgments. Because…

  3. Monitoring Affect States during Effortful Problem Solving Activities

    ERIC Educational Resources Information Center

    D'Mello, Sidney K.; Lehman, Blair; Person, Natalie

    2010-01-01

    We explored the affective states that students experienced during effortful problem solving activities. We conducted a study where 41 students solved difficult analytical reasoning problems from the Law School Admission Test. Students viewed videos of their faces and screen captures and judged their emotions from a set of 14 states (basic…

  4. Monitoring activity in neural circuits with genetically encoded indicators

    PubMed Central

    Broussard, Gerard J.; Liang, Ruqiang; Tian, Lin

    2014-01-01

    Recent developments in genetically encoded indicators of neural activity (GINAs) have greatly advanced the field of systems neuroscience. As they are encoded by DNA, GINAs can be targeted to genetically defined cellular populations. Combined with fluorescence microscopy, most notably multi-photon imaging, GINAs allow chronic simultaneous optical recordings from large populations of neurons or glial cells in awake, behaving mammals, particularly rodents. This large-scale recording of neural activity at multiple temporal and spatial scales has greatly advanced our understanding of the dynamics of neural circuitry underlying behavior—a critical first step toward understanding the complexities of brain function, such as sensorimotor integration and learning. Here, we summarize the recent development and applications of the major classes of GINAs. In particular, we take an in-depth look at the design of available GINA families with a particular focus on genetically encoded calcium indicators (GCaMPs), sensors probing synaptic activity, and genetically encoded voltage indicators. Using the family of the GCaMP as an example, we review established sensor optimization pipelines. We also discuss practical considerations for end users of GINAs about experimental methods including approaches for gene delivery, imaging system requirements, and data analysis techniques. With the growing toolbox of GINAs and with new microscopy techniques pushing beyond their current limits, the age of light can finally achieve the goal of broad and dense sampling of neuronal activity across time and brain structures to obtain a dynamic picture of brain function. PMID:25538558

  5. Management of drug and food interactions with azole antifungal agents in transplant recipients.

    PubMed

    Dodds-Ashley, Elizabeth

    2010-08-01

    Azole antifungal agents are frequently used in hematopoietic stem cell and solid organ transplant recipients for prevention or treatment of invasive fungal infections. However, because of metabolism by or substrate activity for various isoenzymes of the cytochrome P450 system and/or P-glycoprotein, azole antifungals have the potential to interact with many of the drugs commonly used in these patient populations. Thus, to identify drug interactions that may result between azole antifungals and other drugs, we conducted a literature search of the MEDLINE database (1966-December 2009) for English-language articles on drug interaction studies involving the azole antifungal agents fluconazole, itraconazole, voriconazole, and posaconazole. Another literature search between each of the azoles and the immunosuppressants cyclosporine, tacrolimus, and sirolimus, as well as the corticosteroids methylprednisolone, dexamethasone, prednisolone, and prednisone, was also conducted. Concomitant administration of azoles and immunosuppressive agents may cause clinically significant drug interactions resulting in extreme immunosuppression or toxicity. The magnitude and duration of an interaction between azoles and immunosuppressants are not class effects of the azoles, but differ between drug combinations and are subject to interpatient variability. Drug interactions in the transplant recipient receiving azole therapy may also occur with antibiotics, chemotherapeutic agents, and acid-suppressive therapies, among other drugs. Initiation of an azole antifungal in transplant recipients nearly ensures a drug-drug interaction, but often these drugs are required. Management of these interactions first involves knowledge of the potential drug interaction, appropriate dosage adjustments when necessary, and therapeutic or clinical monitoring at an appropriate point in therapy to assess the drug-drug interaction (e.g., immunosuppressive drug concentrations, signs and symptoms of toxicity

  6. Video capsule endoscopy in left ventricular assist device recipients with obscure gastrointestinal bleeding

    PubMed Central

    Amornsawadwattana, Surachai; Nassif, Michael; Raymer, David; LaRue, Shane; Chen, Chien-Huan

    2016-01-01

    AIM: To assess whether video capsule endoscopy (VCE) affects the outcomes of left ventricular assist devices (LVADs) recipients with gastrointestinal bleeding. METHODS: This is a retrospective study of LVAD recipients with obscure gastrointestinal bleeding (OGIB) who underwent VCE at a tertiary medical center between 2005 and 2013. All patients were admitted and monitored with telemetry and all VCE and subsequent endoscopic procedures were performed as inpatients. A VCE study was considered positive only when P2 lesions were found and was regarded as negative if P1 or P0 were identified. All patients were followed until heart transplant, death, or the end of the study. RESULTS: Between 2005 and 2013, 30 patients with LVAD underwent VCE. Completion rate of VCE was 93.3% and there was no capsule retention. No interference of VCE recording or the function of LVAD was found. VCE was positive in 40% of patients (n = 12). The most common finding was active small intestinal bleeding (50%) and small intestinal angiodysplasia (33.3%). There was no difference in the rate of recurrent bleeding between patients with positive and negative VCE study (50.0% vs 55.6%, P = 1.00) during an average of 11.6 ± 9.6 mo follow up. Among patients with positive VCE, the recurrent bleeding rate did not differ whether subsequent endoscopy was performed (50% vs 50%, P = 1.00). CONCLUSION: VCE can be safely performed in LVAD recipients with a diagnostic yield of 40%. VCE does not affect recurrent bleeding in LVAD patients regardless of findings. PMID:27182165

  7. Testing the applicability of rapid on-site enzymatic activity detection for surface water monitoring

    NASA Astrophysics Data System (ADS)

    Stadler, Philipp; Vogl, Wolfgang; Juri, Koschelnik; Markus, Epp; Maximilian, Lackner; Markus, Oismüller; Monika, Kumpan; Peter, Strauss; Regina, Sommer; Gabriela, Ryzinska-Paier; Farnleitner Andreas, H.; Matthias, Zessner

    2015-04-01

    On-site detection of enzymatic activities has been suggested as a rapid surrogate for microbiological pollution monitoring of water resources (e.g. using glucuronidases, galactosidases, esterases). Due to the possible short measuring intervals enzymatic methods have high potential as near-real time water quality monitoring tools. This presentation describes results from a long termed field test. For twelve months, two ColiMinder devices (Vienna Water Monitoring, Austria) for on-site determination of enzymatic activity were tested for stream water monitoring at the experimental catchment HOAL (Hydrological Open Air Laboratory, Center for Water Resource Systems, Vienna University of Technology). The devices were overall able to follow and reflect the diverse hydrological and microbiological conditions of the monitored stream during the test period. Continuous data in high temporal resolution captured the course of enzymatic activity in stream water during diverse rainfall events. The method also proofed sensitive enough to determine diurnal fluctuations of enzymatic activity in stream water during dry periods. The method was able to capture a seasonal trend of enzymatic activity in stream water that matches the results gained from Colilert18 analysis for E. coli and coliform bacteria of monthly grab samples. Furthermore the comparison of ColiMinder data with measurements gained at the same test site with devices using the same method but having different construction design (BACTcontrol, microLAN) showed consistent measuring results. Comparative analysis showed significant differences between measured enzymatic activity (modified fishman units and pmol/min/100ml) and cultivation based analyses (most probable number, colony forming unit). Methods of enzymatic activity measures are capable to detect ideally the enzymatic activity caused by all active target bacteria members, including VBNC (viable but nonculturable) while cultivation based methods cannot detect VBNC

  8. Ebola active monitoring system for travelers returning from West Africa—Georgia, 2014-2015.

    PubMed

    Parham, Mary; Edison, Laura; Soetebier, Karl; Feldpausch, Amanda; Kunkes, Audrey; Smith, Wendy; Guffey, Taylor; Fetherolf, Romana; Sanlis, Kathryn; Gabel, Julie; Cowell, Alex; Drenzek, Cherie

    2015-04-10

    The Ebola virus disease (Ebola) epidemic in West Africa has so far produced approximately 25,000 cases, more than 40 times the number in any previously documented Ebola outbreak. Because of the risk for imported disease from infected travelers, in October 2014 CDC recommended that all travelers to the United States from Ebola-affected countries receive enhanced entry screening and postarrival active monitoring for Ebola signs or symptoms until 21 days after their departure from an Ebola-affected country. The state of Georgia began its active monitoring program on October 25, 2014. The Georgia Department of Public Health (DPH) modified its existing, web-based electronic notifiable disease reporting system to create an Ebola Active Monitoring System (EAMS). DPH staff members developed EAMS from conceptualization to implementation in 6 days. In accordance with CDC recommendations, "low (but not zero) risk" travelers are required to report their daily health status to DPH, and the EAMS dashboard enables DPH epidemiologists to track symptoms and compliance with active monitoring. Through March 31, 2015, DPH monitored 1,070 travelers, and 699 (65%) used their EAMS traveler login instead of telephone or e-mail to report their health status. Medical evaluations were performed on 30 travelers, of whom three were tested for Ebola. EAMS has enabled two epidemiologists to monitor approximately 100 travelers daily, and to rapidly respond to travelers reporting signs and symptoms of potential Ebola virus infection. Similar electronic tracking systems might be useful for other jurisdictions.

  9. New sensitizers and rapid monitoring of their photodynamic activity

    NASA Astrophysics Data System (ADS)

    Torshina, Nadezgda L.; Posypanova, Anna M.; Volkova, Anna I.

    1996-04-01

    At present, there are lots and lots of chemical compounds that are, to a certain extent, photodynamically active. Therefore, the task of carrying out the expressive screening of such compounds has been raised sharply enough. The primary screening in vitro of compounds, with the help of biological liquids, is notable for quickness and cheapness at the same time, it is possible to determine the comparative characteristics of compounds by their photodynamical activity. Decomposition of albumins of a mixture of photosensitizer and biological liquid when irradiating with light is the basis of this method. Efficiency of decomposition of components of biological liquids is determined using biochemical reactions (e.g., those for determining the total albumins or blood hemoglobin). Subsequently, with a sufficient efficiency of a photosensitizer, it will be possible to carry out a study in vivo, with the purpose of establishing accumulation of preparations in tumor.

  10. Monitoring Monitoring Evolving Activity at Popocatepetl Volcano, Mexico, 2000-2001

    NASA Astrophysics Data System (ADS)

    Martin-DelPozzo, A.; Aceves, F.; Bonifaz, R.; Humberto, S.

    2001-12-01

    After 6 years of small eruptions, activity at Mexico's 5,452m high Popocatepetl Volcano in central Mexico, peaked in the December 2000-January 2001 eruptions. Precursors included an important increase in seismicity as well as in magmatic components of spring water and small scale deformation which resulted in growth of a new crater dome from January 16 on. Evacuation of the towns nearest the volcano over Christmas was decided because of the possibility of pyroclastic flows. During the previous years, crater dome growth, contraction and explosive clearing has dominated the activity. The January 22 eruption produced an eruption column approximately 17km high with associated pyroclastic flows. Ejecta was composed of both basic and evolved scoria and pumice and dome lithics. A large proportion of the juvenile material was intermediate between these 2 endmenbers (59-63percent SiO2 and 3.5 to 5.5 MgO) consistent with a small basic pulse entering a more evolved larger batch of magma. The January eruption left a large pit which has been partially infilled by another crater dome this August 2001.

  11. Phosphate-Modified Nucleotides for Monitoring Enzyme Activity.

    PubMed

    Ermert, Susanne; Marx, Andreas; Hacker, Stephan M

    2017-04-01

    Nucleotides modified at the terminal phosphate position have been proven to be interesting entities to study the activity of a variety of different protein classes. In this chapter, we present various types of modifications that were attached as reporter molecules to the phosphate chain of nucleotides and briefly describe the chemical reactions that are frequently used to synthesize them. Furthermore, we discuss a variety of applications of these molecules. Kinase activity, for instance, was studied by transfer of a phosphate modified with a reporter group to the target proteins. This allows not only studying the activity of kinases, but also identifying their target proteins. Moreover, kinases can also be directly labeled with a reporter at a conserved lysine using acyl-phosphate probes. Another important application for phosphate-modified nucleotides is the study of RNA and DNA polymerases. In this context, single-molecule sequencing is made possible using detection in zero-mode waveguides, nanopores or by a Förster resonance energy transfer (FRET)-based mechanism between the polymerase and a fluorophore-labeled nucleotide. Additionally, fluorogenic nucleotides that utilize an intramolecular interaction between a fluorophore and the nucleobase or an intramolecular FRET effect have been successfully developed to study a variety of different enzymes. Finally, also some novel techniques applying electron paramagnetic resonance (EPR)-based detection of nucleotide cleavage or the detection of the cleavage of fluorophosphates are discussed. Taken together, nucleotides modified at the terminal phosphate position have been applied to study the activity of a large diversity of proteins and are valuable tools to enhance the knowledge of biological systems.

  12. A transgenic zebrafish model for monitoring glucocorticoid receptor activity

    PubMed Central

    Krug, Randall G.; Poshusta, Tanya L.; Skuster, Kimberly J.; Berg, MaKayla R.; Gardner, Samantha L.; Clark, Karl J.

    2014-01-01

    Gene regulation resulting from glucocorticoid receptor and glucocorticoid response element interactions is a hallmark feature of stress response signaling. Imbalanced glucocorticoid production and glucocorticoid receptor activity have been linked to socio-economically crippling neuropsychiatric disorders, and accordingly there is a need to develop in vivo models to help understand disease progression and management. Therefore, we developed the transgenic SR4G zebrafish reporter line with six glucocorticoid response elements used to promote expression of a short half-life green fluorescent protein following glucocorticoid receptor activation. Herein, we document the ability of this reporter line to respond to both chronic and acute exogenous glucocorticoid treatment. The green fluorescent protein expression in response to transgene activation was high in a variety of tissues including the brain, and provided single cell resolution in the effected regions. The specificity of these responses is demonstrated using the partial agonist mifepristone and mutation of the glucocorticoid receptor. Importantly, the reporter line also modeled the temporal dynamics of endogenous stress response signaling, including the increased production of the glucocorticoid cortisol following hyperosmotic stress and the fluctuations of basal cortisol concentrations with the circadian rhythm. Taken together, these results characterize our newly developed reporter line for elucidating environmental or genetic modifiers of stress response signaling, which may provide insights to the neuronal mechanisms underlying neuropsychiatric disorders such as major depressive disorder. PMID:24679220

  13. 30 CFR 580.29 - Will BOEM monitor the environmental effects of my activity?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Will BOEM monitor the environmental effects of my activity? 580.29 Section 580.29 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... environmental effects of my activity? We will evaluate the potential of proposed prospecting or...

  14. 30 CFR 580.29 - Will BOEM monitor the environmental effects of my activity?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Will BOEM monitor the environmental effects of my activity? 580.29 Section 580.29 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... environmental effects of my activity? We will evaluate the potential of proposed prospecting or...

  15. 30 CFR 580.29 - Will BOEM monitor the environmental effects of my activity?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Will BOEM monitor the environmental effects of my activity? 580.29 Section 580.29 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... environmental effects of my activity? We will evaluate the potential of proposed prospecting or...

  16. Financial Aid Recipients: An Appraisal By Race

    ERIC Educational Resources Information Center

    Stewart, Mac A.

    1975-01-01

    This study was designed to examine seven variables of a segment of the 1971 freshman class at Ohio State University in order to identify similarities and differences between black financial aid recipients and white financial aid recipients. Significant differences were found between blacks and whites on all variables investigated. (Author)

  17. 40 CFR 7.85 - Recipients.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... summarizing the complaint or setting forth the basis for the belief that discrimination may exist. (c) Self-evaluation. Each recipient must conduct a self-evaluation of its administrative policies and practices, to.... When conducting the self-evaluation, the recipient shall consult with interested and involved...

  18. 40 CFR 7.85 - Recipients.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... discrimination may exist. (c) Self-evaluation. (1) Each recipient must conduct a self-evaluation of its... discrimination prohibited by this part. When conducting the self-evaluation, the recipient shall consult with... written self-evaluation of its compliance under the Age Discrimination Act as part of a compliance...

  19. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility §...

  20. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility §...

  1. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility §...

  2. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility §...

  3. 7 CFR 248.6 - Recipient eligibility.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Recipient eligibility. 248.6 Section 248.6 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS WIC FARMERS' MARKET NUTRITION PROGRAM (FMNP) Recipient Eligibility §...

  4. Magneto-impedance sensor for quasi-noncontact monitoring of breathing, pulse rate and activity status

    NASA Astrophysics Data System (ADS)

    Corodeanu, S.; Chiriac, H.; Radulescu, L.; Lupu, N.

    2014-05-01

    Results on the development and testing of a novel magnetic sensor based on the detection of the magneto-impedance variation due to changes in the permeability of an amorphous wire are reported. The proposed application is the quasi-noncontact monitoring of the breathing frequency and heart rate for diagnosing sleep disorders. Patient discomfort is significantly decreased by transversally placing the sensitive element onto the surface of a flexible mattress in order to detect its deformation associated with cardiorespiratory activity and body movements. The developed sensor has a great application potential in monitoring the vital signs during sleep, with special advantages for children sleep monitoring.

  5. Monitoring gross alpha and beta activity in liquids by using ZnS(Ag) scintillation detectors

    SciTech Connect

    Stevanato, L.; Cester, D.; Filippi, D.; Lunardon, M.; Mistura, G.; Moretto, S.; Viesti, G.; Badocco, D.; Pastore, P.; Romanini, F.

    2015-07-01

    In this work the possibility of monitoring gross alpha and beta activity in liquids using EJ-444 was investigated. Specific tests were carried out to determine the change of the detector properties in water tests. Possible protecting coating is also proposed and tested. Alpha/beta real-time monitoring in liquids is a goal of the EU project TAWARA{sub R}TM. (authors)

  6. Liver transplantation in HIV-infected recipients.

    PubMed

    Roland, Michelle E; Stock, Peter G

    2006-08-01

    Although human immunodeficiency virus (HIV)-infected patients are living longer and dying less often from complications related to acquired immunodeficiency syndrome (AIDS), they are experiencing significant morbidity and mortality related to end-stage liver disease. Advances in the management of HIV disease have made it difficult to continue denying transplantation to this population based upon futility arguments alone. Patient and graft survival rates in HIV-infected study subjects appear similar to those in large transplant databases. There are no reports suggesting significant HIV disease progression. There are substantial interactions between immunosuppressants and antiretroviral drugs that require careful monitoring and dose adjustment. The evaluation and management of HIV-infected transplant candidates and recipients require excellent communication among a multidisciplinary team and the primary HIV care provider. It is critical that HIV clinicians and hepatologists are aware that liver transplantation is an option for HIV-infected patients at many transplant centers as delays in referral result in unnecessary mortality during the pretransplantation evaluation process.

  7. Crucial Role for Neuronal Nitric Oxide Synthase in Early Microcirculatory Derangement and Recipient Survival following Murine Pancreas Transplantation

    PubMed Central

    Cardini, Benno; Watschinger, Katrin; Hermann, Martin; Obrist, Peter; Oberhuber, Rupert; Brandacher, Gerald; Chuaiphichai, Surawee; Channon, Keith M.; Pratschke, Johann; Maglione, Manuel; Werner, Ernst R.

    2014-01-01

    Objective Aim of this study was to identify the nitric oxide synthase (NOS) isoform involved in early microcirculatory derangements following solid organ transplantation. Background Tetrahydrobiopterin donor treatment has been shown to specifically attenuate these derangements following pancreas transplantation, and tetrahydrobiopterin-mediated protective effects to rely on its NOS-cofactor activity, rather than on its antioxidant capacity. However, the NOS-isoform mainly involved in this process has still to be defined. Methods Using a murine pancreas transplantation model, grafts lacking one of the three NOS-isoforms were compared to grafts from wild-type controls. Donors were treated with either tetrahydrobiopterin or remained untreated. All grafts were subjected to 16 h cold ischemia time and transplanted into wild-type recipients. Following 4 h graft reperfusion, microcirculation was analysed by confocal intravital fluorescence microscopy. Recipient survival was monitored for 50 days. Results Transplantation of the pancreas from untreated wild-type donor mice resulted in microcirculatory damage of the transplanted graft and no recipient survived more than 72 h. Transplanting grafts from untreated donor mice lacking either endothelial or inducible NOS led to similar outcomes. In contrast, donor treatment with tetrahydrobiopterin prevented microcirculatory breakdown enabling long-term survival. Sole exception was transplantation of grafts from untreated donor mice lacking neuronal NOS. It resulted in intact microvascular structure and long-term recipient survival, either if donor mice were untreated or treated with tetrahydrobiopterin. Conclusion We demonstrate for the first time the crucial involvement of neuronal NOS in early microcirculatory derangements following solid organ transplantation. In this model, protective effects of tetrahydrobiopterin are mediated by targeting this isoform. PMID:25389974

  8. Monitoring Criminal Activity through Invisible Fluorescent "Peptide Coding" Taggants.

    PubMed

    Gooch, James; Goh, Hilary; Daniel, Barbara; Abbate, Vincenzo; Frascione, Nunzianda

    2016-04-19

    Complementing the demand for effective crime reduction measures are the increasing availability of commercial forensic "taggants", which may be used to physically mark an object in order to make it uniquely identifiable. This study explores the use of a novel "peptide coding" reagents to establish evidence of contact transfer during criminal activity. The reagent, containing a fluorophore dispersed within an oil-based medium, also includes a unique synthetic peptide sequence that acts as a traceable "code" to identify the origin of the taggant. The reagent is detectable through its fluorescent properties, which then allows the peptide to be recovered by swabbing and extracted for electrospray ionization-mass spectrometry (ESI-MS) analysis via a simple liquid-liquid extraction procedure. The performance of the reagent in variable conditions that mimic the limits of a real world use are investigated.

  9. Active System for Electromagnetic Perturbation Monitoring in Vehicles

    NASA Astrophysics Data System (ADS)

    Matoi, Adrian Marian; Helerea, Elena

    Nowadays electromagnetic environment is rapidly expanding in frequency domain and wireless services extend in terms of covered area. European electromagnetic compatibility regulations refer to limit values regarding emissions, as well as procedures for determining susceptibility of the vehicle. Approval procedure for a series of cars is based on determining emissions/immunity level for a few vehicles picked randomly from the entire series, supposing that entire vehicle series is compliant. During immunity assessment, the vehicle is not subjected to real perturbation sources, but exposed to electric/magnetic fields generated by laboratory equipment. Since current approach takes into account only partially real situation regarding perturbation sources, this paper proposes an active system for determining electromagnetic parameters of vehicle's environment, that implements a logical diagram for measurement, satisfying the imposed requirements. This new and original solution is useful for EMC assessment of hybrid and electrical vehicles.

  10. Individual differences in epistemic motivation and brain conflict monitoring activity.

    PubMed

    Kossowska, Małgorzata; Czarnek, Gabriela; Wronka, Eligiusz; Wyczesany, Miroslaw; Bukowski, Marcin

    2014-06-06

    It is well documented that motivation toward closure (NFC), defined as a desire for a quick and unambiguous answer to a question and an aversion to uncertainty, is linked to more structured, rigid, and persistent cognitive styles. However, the neurocognitive correlates of NFC have never been tested. Thus, using event-related potentials, we examined the hypothesis that NFC is associated with the neurocognitive process for detecting discrepancies between response tendencies and higher level intentions. We found that greater NFC is associated with lower conflict-related anterior cingulate activity, suggesting lower sensitivity to cues for altering a habitual response pattern and lower sensitivity to committing errors. This study provides evidence that high NFC acts as a bulwark against anxiety-producing uncertainty and minimizes the experience of error.

  11. A comparison of red blood cell transfusion utilization between anti-activated factor X and activated partial thromboplastin monitoring in patients receiving unfractionated heparin.

    PubMed

    Belk, K W; Laposata, M; Craver, C

    2016-11-01

    Essentials Anti-activated factor X (Anti-Xa) monitoring is more precise than activated partial thromboplastin (aPTT). 20 804 hospitalized cardiovascular patients monitored with Anti-Xa or aPTT were analyzed. Adjusted transfusion rates were significantly lower for patients monitored with Anti-Xa. Adoption of Anti-Xa protocols could reduce transfusions among cardiovascular patients in the US.

  12. Monitoring EERE's Recovery Act Portfolio

    SciTech Connect

    2011-01-01

    Performance monitoring of Recovery Act projects within EERE has been an ongoing effort. Project recipients have been reporting technical and financial progress to project officers on a quarterly basis.

  13. Use of a consumer market activity monitoring and feedback device improves exercise capacity and activity levels in COPD.

    PubMed

    Caulfield, Brian; Kaljo, Indira; Donnelly, Seamas

    2014-01-01

    COPD is associated with a gradual decline in physical activity, which itself contributes to a worsening of the underlying condition. Strategies that improve physical activity levels are critical to halt this cycle. Wearable sensor based activity monitoring and persuasive feedback might offer a potential solution. However it is not clear just how much intervention might be needed in this regard - i.e. whether programmes need to be tailored specifically for the target clinical population or whether more simple activity monitoring and feedback solutions, such as that offered in consumer market devices, might be sufficient. This research was carried out to investigate the impact of 4 weeks of using an off the shelf consumer market activity monitoring and feedback application on measures of physical activity, exercise capacity, and health related quality of life in a population of 10 Stage I and II COPD patients. Results demonstrate a significant and positive effect on exercise capacity (measured using a 6-minute walk test) and activity levels (measured in terms of average number of steps per hour) yet no impact on health related quality of life (St Georges Respiratory Disease Questionnaire).

  14. Assessing Human Activity in Elderly People Using Non-Intrusive Load Monitoring

    PubMed Central

    Alcalá, José M.; Ureña, Jesús; Hernández, Álvaro; Gualda, David

    2017-01-01

    The ageing of the population, and their increasing wish of living independently, are motivating the development of welfare and healthcare models. Existing approaches based on the direct heath-monitoring using body sensor networks (BSN) are precise and accurate. Nonetheless, their intrusiveness causes non-acceptance. New approaches seek the indirect monitoring through monitoring activities of daily living (ADLs), which proves to be a suitable solution. ADL monitoring systems use many heterogeneous sensors, are less intrusive, and are less expensive than BSN, however, the deployment and maintenance of wireless sensor networks (WSN) prevent them from a widespread acceptance. In this work, a novel technique to monitor the human activity, based on non-intrusive load monitoring (NILM), is presented. The proposal uses only smart meter data, which leads to minimum intrusiveness and a potential massive deployment at minimal cost. This could be the key to develop sustainable healthcare models for smart homes, capable of complying with the elderly people’ demands. This study also uses the Dempster-Shafer theory to provide a daily score of normality with regard to the regular behavior. This approach has been evaluated using real datasets and, additionally, a benchmarking against a Gaussian mixture model approach is presented. PMID:28208672

  15. Wireless structural health monitoring for critical members of civil infrastructures using piezoelectric active sensors

    NASA Astrophysics Data System (ADS)

    Park, Seunghee; Yun, Chung-Bang; Inman, Daniel J.; Park, Gyuhae

    2008-03-01

    This paper presents several challenging issues on wireless structural health monitoring techniques for critical members of civil infrastructures using piezoelectric active sensors. The basic concept of the techniques is to monitor remotely the structural integrity by observing the impedance variations at the piezoelectric active sensors distributed to critical members of a host structure. An active sensing node incorporating on-board microprocessor and radio frequency telemetry is introduced in a sense of tailoring wireless sensing technology to the impedance method. A data compression algorithm using principal component analysis is embedded into the on-board chip of the active sensing node. The data compression algorithm would promote efficiency in terms of both power management and noise elimination of the active sensor node. Finally, a piezoelectric sensor self-diagnosis issue is touched introducing a new impedance model equation that incorporates the effects of sensor and bonding defects.

  16. Crosswell CASSM(Continuous Active-Source Seismic Monitoring): Recent Developments (Invited)

    NASA Astrophysics Data System (ADS)

    Daley, T. M.; Niu, F.; Ajo Franklin, J. B.; Solbau, R.; Silver, P. G.

    2009-12-01

    Continuous active-source monitoring using borehole sources and sensors in a crosswell configuration has proven to be a useful tool for monitoring subsurface processes (Silver, et al, 2007; Daley, et al, 2007; Niu, et al, 2008). This recent work has focused on two applications: monitoring stress changes related to seismicity and monitoring changes in fluid distribution related to geologic storage of CO2. Field tests have demonstrated precision in travel time measurement of up to 1.1 x 10-7 s, and in velocity perturbation measurement of up to 1.1 x 10-5 (Niu, et al 2008). In this talk I will summarize our preceding work and discuss current developments. Current efforts address both hardware and design challenges to improving the methodology. Hardware issues include deployment of multiple piezoelectric sources in shallow and deep boreholes, source and sensor deployment on tubing inside casing, and deployment with other monitoring instrumentation. Design issues are focused on use of multiple sources and/or sensors to obtain optimal spatial resolution for monitoring processes in the interwell region. This design issue can be investigated with optimal experiment design theory. New field experiments for monitoring seismicity (at SAFOD) and CO2 injection (at a US Dept of Energy pilot) are in the design/deployment stage. Current status of these projects will be discussed. References: Silver, P.G., Daley, T.M., Niu, F., Majer, E.L., 2007, Active source monitoring of crosswell seismic travel time for stress induced changes, Bulletin of Seismological Society of America, v97, n1B, p281-293. Daley, T.M., R.D. Solbau, J.B. Ajo-Franklin, S.M. Benson, 2007, Continuous active-source monitoring of CO2 injection in a brine aquifer, Geophysics, v72, n5, pA57-A61, DOI:10.1190/1.2754716. Niu, F., Silver, P.G., Daley, T.M., Cheng, X., Majer, E.L., 2008, Preseismic velocity changes observed from active source monitoring at the Parkfield SAFOD drill site, Nature, 454, 204-208, DOI:10

  17. On indoor radon contamination monitoring with SSNTDs: Experimental results concerning plate-out and self-plate-out effects

    NASA Astrophysics Data System (ADS)

    Bigazzi, G.; Hadler, J. C.; Paulo, S. R.

    1989-08-01

    Measurements of the alpha activities of 222Rn and its daughters were performed, both inside a glass recipient and in closed rooms, employing SSNTDs (CR-39 and nuclear emulsion). The experimental results presented here show that plate-out and self-plate-out effects should be taken into account when SSNTDs are employed in indoor radon contamination monitoring.

  18. Chemical sensor platform for non-invasive monitoring of activity and dehydration.

    PubMed

    Solovei, Dmitry; Žák, Jaromír; Majzlíková, Petra; Sedláček, Jiří; Hubálek, Jaromír

    2015-01-14

    A non-invasive solution for monitoring of the activity and dehydration of organisms is proposed in the work. For this purpose, a wireless standalone chemical sensor platform using two separate measurement techniques has been developed. The first approach for activity monitoring is based on humidity measurement. Our solution uses new humidity sensor based on a nanostructured TiO2 surface for sweat rate monitoring. The second technique is based on monitoring of potassium concentration in urine. High level of potassium concentration denotes clear occurrence of dehydration. Furthermore, a Wireless Body Area Network (WBAN) was developed for this sensor platform to manage data transfer among devices and the internet. The WBAN coordinator controls the sensor devices and collects and stores the measured data. The collected data is particular to individuals and can be shared with physicians, emergency systems or athletes' coaches. Long-time monitoring of activity and potassium concentration in urine can help maintain the appropriate water intake of elderly people or athletes and to send warning signals in the case of near dehydration. The created sensor system was calibrated and tested in laboratory and real conditions as well. The measurement results are discussed.

  19. Infections in liver transplant recipients

    PubMed Central

    Romero, Fabian A; Razonable, Raymund R

    2011-01-01

    Liver transplantation is a standard life-saving procedure for the treatment of many end-stage liver diseases. The success of this procedure may be limited by infectious complications. In this article, we review the contemporary state of infectious complications during the post-operative period, with particular emphasis on those that occur most commonly during the first 6 mo after liver transplantation. Bacteria, and less commonly Candida infections, remain the predominant pathogens during the immediate post-operative period, especially during the first month, and infections caused by drug-resistant strains are emerging. Infections caused by cytomegalovirus and Aspergillus sp. present clinically during the “opportunistic” period characterized by intense immunosuppression. As newer potent immunosuppressive therapies with the major aim of reducing allograft rejection are developed, one potential adverse effect is an increase in certain infections. Hence, it is essential for liver transplant centers to have an effective approach to prevention that is based on predicted infection risk, local antimicrobial resistance patterns, and surveillance. A better understanding of the common and most important infectious complications is anticipated to lead to improvements in quality of life and survival of liver transplant recipients. PMID:21603030

  20. Sex differences among recipients of benzodiazepines in Dutch general practice.

    PubMed Central

    van der Waals, F W; Mohrs, J; Foets, M

    1993-01-01

    OBJECTIVE--To analyse sex differences among recipients of benzodiazepines in Dutch general practice. DESIGN--Study of consultations and associated interventions as recorded in the Dutch national survey of general practice. SETTING--Practices of 45 general practitioners monitored during 1 April to 30 June 1987. SUBJECTS--61,249 patients (29,035 (47.4%) men in the age groups 19-44, 45-64, and 65 years and over. MAIN OUTCOME MEASURES--Symptoms among recipients of repeat as well as new benzodiazepine prescriptions stratified by sex and age. RESULTS--Prescriptions for benzodiazepines were found to be significantly more common among women than among men, (a) after correcting for the sex distribution of the total patient population, and (b) in the two oldest age groups after correcting for the number of consultations. Of all prescriptions for benzodiazepines, 89% (6055/6777) were repeats and 70% (4759/6777) requests. Only 9% (439/4759) of these were authorized by the general practitioner, the rest being issued by the general practitioner's assistant after he or she had referred to the diagnosis in the patient's record. In contrast, only three (1%) of the 492 first time recipients of benzodiazepines had requested a prescription and were not seen by the general practitioner. Women (43/96; 45%) aged 45-64 years received their first prescription for benzodiazepines almost twice as often as men (15/63; 24%) without symptoms or a diagnosis being an indication (female to male relative risk 1.88 (95% confidence interval 1.15 to 3.08)). CONCLUSIONS--The sex difference among first time recipients of benzodiazepines seems to be due to general practitioners being less stringent when prescribing this drug for women. The difference continues in repeat prescriptions, physicians failing to check adequately the need for these. PMID:8104066

  1. Urinary tract infection in kidney transplant recipients.

    PubMed

    Chacón-Mora, Natalia; Pachón Díaz, Jerónimo; Cordero Matía, Elisa

    2016-04-21

    Infectious complications remain a major cause of morbidity and mortality among transplant recipients. Urinary tract infection (UTI) is the most common infectious complication in kidney transplant recipients with a reported incidence from 25% to 75%, varies widely likely due to differences in definition, diagnostic criteria, study design, and length of observation. We sought reviews the incidence and importance of urinary tract infection on graft survival, the microbiology with special emphasis on multidrug resistant microorganisms, the therapeutic management of UTI and the prophylaxis of recurrent UTI among solid organ transplant recipients, highlighting the need for prospective clinical trials to unify the clinical management in this population.

  2. Therapeutic regulation of systemic inflammation in xenograft recipients.

    PubMed

    Iwase, Hayato; Liu, Hong; Li, Tao; Zhang, Zhongquiang; Gao, Bingsi; Hara, Hidetaka; Wijkstrom, Martin; Long, Cassandra; Saari, Ryan; Ayares, David; Cooper, David K C; Ezzelarab, Mohamed B

    2017-03-12

    Inflammation is known to preclude tolerance after transplantation. We have previously shown that systemic inflammation in xenograft recipients (SIXR) precedes activation of coagulation in the absence of T cell responses. Accordingly, SIXR may amplify innate and adaptive immune responses against xenografts after pig-to-primate xenotransplantation, even with efficient immunosuppressive therapy. We evaluated the impact of anti-inflammatory agents on pro-inflammatory cytokines and chemokines in pig artery patch and heart xenograft recipients. Baboons received an artery patch (Group1, n=8) or heart (Group2, n=4) from genetically engineered pigs. All baboons received lymphodepletion with thymoglobulin (ATG) and costimulation blockade-based immunosuppression (anti-CD40 and/or CTLA4Ig). In Group1, baboons received either (i) no anti-inflammatory agents (n=2), (ii) cobra venom factor (CVF, n=2), (iii) α1-antitrypsin (AAT, n=2), or (iv) interleukin (IL)-6 receptor antagonist (IL-6RA, n=2). In Group2, all baboon received corticosteroids, either without (n=2) or with (n=2) IL-6RA. Serum IFN-γ, TNF-α, IL-1β, IL-17, IL-6, IL-8, MCP-1, and sCD40L levels were measured by Luminex. Fibrinogen, D-dimers, and C-reactive protein (C-RP) were also measured. Recipient baboon T cell proliferation was evaluated by mixed lymphocyte reaction (MLR) before and after transplantation. Pig and baboon tissue factor (TF) mRNA levels in heart xenografts were measured by RT-PCR. In no recipient was a marked increase in T cell response to pig cells observed after transplantation. In Groups 1 and 2, post-transplantation levels of IFN-γ, TNF-α, IL-1β, and IL-17 remained comparable to or lower than pre-transplant levels, except in one heart recipient that succumbed to CMV infection. In Group1, when no anti-inflammatory agent was administered, post-transplant levels of IL-6, IL-8, and MCP-1 were elevated. After CVF, IL-6, IL-8, and MCP-1 remained low. After IL-6RA, IL-6 and MCP-1 were elevated

  3. Pattern of active and inactive sequences of diabetes self-monitoring in mobile phone and paper diary users.

    PubMed

    Padhye, Nikhil S; Jing Wang

    2015-01-01

    In a pilot randomized controlled trial involving overweight or obese participants with type 2 diabetes, we find that smartphone users have sharply higher adherence to self-monitoring of diet, physical activity, blood glucose, and body weight, as compared to paper diary users. By characterizing the pattern of adherence with the probability of continuation of active and inactive sequences of self-monitoring, we find that smartphone users have longer active sequences of self-monitoring of all four behaviors that were being monitored. Smartphone users are also quicker to resume self-monitoring of diet and physical activity after a lapse in self-monitoring, whereas paper diary users have shorter inactive sequences for monitoring blood glucose and body weight. The findings are informative for data collection methodology in this burgeoning area of research.

  4. Geochemical monitoring of thermal waters in Slovenia: relationships to seismic activity.

    PubMed

    Zmazek, B; Italiano, F; Zivcić, M; Vaupotic, J; Kobal, I; Martinelli, G

    2002-12-01

    Thermally anomalous fluids released in seismic areas in Slovenia were the subjects of geochemical monitoring. Thermal waters were surveyed from the seismically active area of Posocje (Bled and Zatolmin; NW Slovenia) and from Rogaska Slatina in eastern Slovenia. Continuous monitoring of geochemical parameters (radon concentration, electrical conductivity, and water temperature) was performed with discrete gas sampling for their (3)He/(4)He ratio. The observed values were correlated with meteorological parameters (rainfall, barometric pressure and air temperature) and with seismic activity. Only a few earthquakes occurred in the vicinity of the measuring sites during the monitoring period. Nevertheless, changes in radon concentration, water temperature, electrical conductivity and helium isotopic ratio were detected at the three thermal springs in the periods preceding the earthquakes. A close correlation was also observed of both water temperature and electrical conductivity with the Earth tide, making the observations in the selected sites a promising tool for addressing the widely debated question of earthquake prediction.

  5. Inventory of non-federally funded marine pollution research, development, and monitoring activities: West Coast region

    SciTech Connect

    Canton, G.M.; Opresko, D.M.; Weaver, R.S.

    1987-12-01

    Knowledge of current marine pollution research and monitoring programs is an important factor in planning and guiding future national efforts to control such pollution. To supplement these reports on Federal activities, NMPPO published a series of reports in 1980 on non-federally funded marine pollution research and monitoring activities in various regions. The following document presents an update of one of these reports. It presents an inventory of the non-federally funded research and monitoring projects for the West Coast region of the United States. It is one in a series of four updates that will collectively provide an updated inventory of non-federally funded projects for all the coastal regions of the United States.

  6. Influence of social connectedness, communication and monitoring on adolescent sexual activity in Ghana.

    PubMed

    Kumi-Kyereme, Akwasi; Awusabo-Asare, Kofi; Biddlecom, Ann; Tanle, Augustine

    2007-12-01

    This paper examines connectedness to, communication with and monitoring of unmarried adolescents in Ghana by parents, other adults, friends and key social institutions and the roles these groups play with respect to adolescent sexual activity. The paper draws on 2004 nationally-representative survey data and qualitative evidence from focus group discussions and in-depth interviews with adolescents in 2003. Adolescents show high levels of connectedness to family, adults, friends, school and religious groups. High levels of adult monitoring are also observed, but communication with family about sex-related matters was not as high as with non-family members. The qualitative data highlight gender differences in communication. Multivariate analysis of survey data shows a strong negative relationship between parental monitoring and recent sexual activity for males and females, and limited effects of communication. Creating a supportive environment and showing interest in the welfare of adolescents appear to promote positive sexual and reproductive health outcomes.

  7. Validity of activity monitors in health and chronic disease: a systematic review

    PubMed Central

    2012-01-01

    The assessment of physical activity in healthy populations and in those with chronic diseases is challenging. The aim of this systematic review was to identify whether available activity monitors (AM) have been appropriately validated for use in assessing physical activity in these groups. Following a systematic literature search we found 134 papers meeting the inclusion criteria; 40 conducted in a field setting (validation against doubly labelled water), 86 in a laboratory setting (validation against a metabolic cart, metabolic chamber) and 8 in a field and laboratory setting. Correlation coefficients between AM outcomes and energy expenditure (EE) by the criterion method (doubly labelled water and metabolic cart/chamber) and percentage mean differences between EE estimation from the monitor and EE measurement by the criterion method were extracted. Random-effects meta-analyses were performed to pool the results across studies where possible. Types of devices were compared using meta-regression analyses. Most validation studies had been performed in healthy adults (n = 118), with few carried out in patients with chronic diseases (n = 16). For total EE, correlation coefficients were statistically significantly lower in uniaxial compared to multisensor devices. For active EE, correlations were slightly but not significantly lower in uniaxial compared to triaxial and multisensor devices. Uniaxial devices tended to underestimate TEE (−12.07 (95%CI; -18.28 to −5.85) %) compared to triaxial (−6.85 (95%CI; -18.20 to 4.49) %, p = 0.37) and were statistically significantly less accurate than multisensor devices (−3.64 (95%CI; -8.97 to 1.70) %, p<0.001). TEE was underestimated during slow walking speeds in 69% of the lab validation studies compared to 37%, 30% and 37% of the studies during intermediate, fast walking speed and running, respectively. The high level of heterogeneity in the validation studies is only partly explained by the type of activity

  8. Activity Learning as a Foundation for Security Monitoring in Smart Homes.

    PubMed

    Dahmen, Jessamyn; Thomas, Brian L; Cook, Diane J; Wang, Xiaobo

    2017-03-31

    Smart environment technology has matured to the point where it is regularly used in everyday homes as well as research labs. With this maturation of the technology, we can consider using smart homes as a practical mechanism for improving home security. In this paper, we introduce an activity-aware approach to security monitoring and threat detection in smart homes. We describe our approach using the CASAS smart home framework and activity learning algorithms. By monitoring for activity-based anomalies we can detect possible threats and take appropriate action. We evaluate our proposed method using data collected in CASAS smart homes and demonstrate the partnership between activity-aware smart homes and biometric devices in the context of the CASAS on-campus smart apartment testbed.

  9. The Activation and Monitoring of Memories Produced by Words and Pseudohomophones

    ERIC Educational Resources Information Center

    Cortese, Michael J.; Khanna, Maya M.; White, Katherine K.; Veljkovic, Ilija; Drumm, Geoffery

    2008-01-01

    Using the DRM paradigm, our experiments examined the activation and monitoring of memories in semantic and phonological networks. Participants viewed lists of words and/or pseudohomophones (e.g., "dreem"). In Experiment 1, participants verbally recalled lists of semantic associates or attempted to write them as they appeared during study. False…

  10. 14 CFR 405.1 - Monitoring of licensed, permitted, and other activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Monitoring of licensed, permitted, and other activities. 405.1 Section 405.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL... manufacturing, production, testing, and training facilities, or assembly sites used by any contractor,...

  11. Monitoring Phospholipase A2 Activity with Gd-encapsulated Phospholipid Liposomes

    PubMed Central

    Cheng, Zhiliang; Tsourkas, Andrew

    2014-01-01

    To date, numerous analytical methods have been developed to monitor phospholipase A2 (PLA2) activity. However, many of these methods require the use of unnatural PLA2 substrates that may alter enzyme kinetics, and probes that cannot be extended to applications in more complex environments. It would be desirable to develop a versatile assay that monitors PLA2 activity based on interactions with natural phospholipids in complex biological samples. Here, we developed an activatable T1 magnetic resonance (MR) imaging contrast agent to monitor PLA2 activity. Specifically, the clinically approved gadolinium (Gd)-based MR contrast agent, gadoteridol, was encapsulated within nanometer-sized phospholipid liposomes. The encapsulated Gd exhibited a low T1-weighted signal, due to low membrane permeability. However, when the phospholipids within the liposomal membrane were hydrolyzed by PLA2, encapsulated Gd was released into bulk solution, resulting in a measureable change in the T1-relaxation time. These activatable MR contrast agents can potentially be used as nanosensors for monitoring of PLA2 activity in biological samples with minimal sample preparation. PMID:25376186

  12. IDEA Fiscal Monitoring and Support Activities 2011-2012 Quick Reference Document

    ERIC Educational Resources Information Center

    Regional Resource Center Program, 2011

    2011-01-01

    This Quick Reference Document is being distributed by the Regional Resource Center Program ARRA/Fiscal Priority Team to provide RRCP state liaisons and other (Technical Assistance) TA providers with a summary of critical fiscal monitoring and support activities they may be involved in during calendar years 2011 and 2012. Like other documents in…

  13. GREENHOUSE GAS (GHG) MITIGATION AND MONITORING TECHNOLOGY PERFORMANCE: ACTIVITIES OF THE GHG TECHNOLOGY VERIFICATION CENTER

    EPA Science Inventory

    The paper discusses greenhouse gas (GHG) mitigation and monitoring technology performance activities of the GHG Technology Verification Center. The Center is a public/private partnership between Southern Research Institute and the U.S. EPA's Office of Research and Development. It...

  14. Employing Magnetic Levitation to Monitor Reaction Kinetics and Measure Activation Energy

    ERIC Educational Resources Information Center

    Benz, Lauren; Cesafsky, Karen E.; Le, Tran; Park, Aileen; Malicky, David

    2012-01-01

    This article describes a simple and inexpensive undergraduate-level kinetics experiment that uses magnetic levitation to monitor the progress and determine the activation energy of a condensation reaction on a polymeric solid support. The method employs a cuvette filled with a paramagnetic solution positioned between two strong magnets. The…

  15. DEVELOPMENT OF AN ETD SURVEILLANCE CHECKLIST FOR MONITORING EPA RESEARCH ACTIVITIES

    EPA Science Inventory

    DEVELOPMENT OF AN ETD SURVEILLANCE CHECKLIST FOR MONITORING EPA RESEARCH ACTIVITIES, Thomas J. Hughes, National Health and Environmental Effects Research Laboratory (NHEERL), ORD, U.S. EPA, Experimental Toxicology Division (ETD), MD 66, RTP, NC 27711

    Research studies condu...

  16. Physical Activity Monitoring: Gadgets and Uses. Article #6 in a 6-Part Series

    ERIC Educational Resources Information Center

    Mears, Derrick

    2010-01-01

    An early 15th century drawing by Leonardo da Vinci depicted a device that used gears and a pendulum that moved in synchronization with the wearer as he or she walked. This is believed to be the early origins of today's physical activity monitoring devices. Today's devices have vastly expanded on da Vinci's ancient concept with a myriad of options…

  17. 14 CFR 405.1 - Monitoring of licensed, permitted, and other activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Monitoring of licensed, permitted, and other activities. 405.1 Section 405.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS AND ENFORCEMENT §...

  18. 14 CFR 405.1 - Monitoring of licensed, permitted, and other activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Monitoring of licensed, permitted, and other activities. 405.1 Section 405.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS AND ENFORCEMENT §...

  19. 14 CFR 405.1 - Monitoring of licensed, permitted, and other activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Monitoring of licensed, permitted, and other activities. 405.1 Section 405.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS AND ENFORCEMENT §...

  20. 14 CFR 405.1 - Monitoring of licensed, permitted, and other activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Monitoring of licensed, permitted, and other activities. 405.1 Section 405.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS AND ENFORCEMENT §...

  1. OLAM: A wearable, non-contact sensor for continuous heart-rate and activity monitoring.

    PubMed

    Albright, Ryan K; Goska, Benjamin J; Hagen, Tory M; Chi, Mike Y; Cauwenberghs, G; Chiang, Patrick Y

    2011-01-01

    A wearable, multi-modal sensor is presented that can non-invasively monitor a patient's activity level and heart function concurrently for more than a week. The 4 in(2) sensor incorporates both a non-contact heartrate sensor and a 5-axis inertial measurement unit (IMU), allowing simultaneous heart, respiration, and movement monitoring without requiring physical contact with the skin [1]. Hence, this Oregon State University Life and Activity Monitor (OLAM) provides the unique opportunity to combine motion data with heart-rate information, enabling assessment of actual physical activity beyond conventional movement sensors. OLAM also provides a unique platform for non-contact sensing, enabling the filtering of movement artifacts generated by the non-contact capacitive interface, using the IMU data as a movement noise channel. Intended to be used in clinical trials for weeks at a time with no physician intervention, the OLAM allows continuous non-invasive monitoring of patients, providing the opportunity for long-term observation into a patient's physical activity and subtle longitudinal changes.

  2. Exercise Therapy for Management of Type 2 Diabetes Mellitus: Superior Efficacy of Activity Monitors over Pedometers

    PubMed Central

    Umezono, Tomoya; Fukagawa, Masafumi

    2016-01-01

    We compared the efficacy of activity monitor (which displays exercise intensity and number of steps) versus that of pedometer in exercise therapy for patients with type 2 diabetes. The study subjects were divided into the activity monitor group (n = 92) and pedometer group (n = 95). The primary goal was improvement in hemoglobin A1c (HbA1c). The exercise target was set at 8,000 steps/day and 20 minutes of moderate-intensity exercise (≥3.5 metabolic equivalents). The activity monitor is equipped with a triple-axis accelerometer sensor capable of measuring medium-intensity walking duration, number of steps, walking distance, calorie consumption, and total calorie consumption. The pedometer counts the number of steps. Blood samples for laboratory tests were obtained during the visits. The first examination was conducted at the start of the study and repeated at 2 and 6 months. A significant difference in the decrease in HbA1c level was observed between the two groups at 2 months. The results suggest that the use of activity level monitor that displays information on exercise intensity, in addition to the number of steps, is useful in exercise therapy as it enhances the concept of exercise therapy and promotes lowering of HbA1c in diabetic patients. PMID:27761471

  3. Determining Daily Physical Activity Levels of Youth with Developmental Disabilities: Days of Monitoring Required?

    ERIC Educational Resources Information Center

    Kim, So-Yeun; Yun, Joonkoo

    2009-01-01

    This study examined sources of variability in physical activity (PA) of youth with developmental disabilities (DD), and determined the optimal number of days required for monitoring PA. Sixteen youth with DD wore two pedometers and two accelerometers for 9 days, including 5 weekdays (W) and 2 weekends (WK). A two-facet in fully crossed two-way…

  4. Small Schools Mathematics Curriculum, 9-12: Scope Objectives, Activities, Resources, Monitoring Procedures.

    ERIC Educational Resources Information Center

    Nelson, JoAnne, Ed.; And Others

    The grade 9-12 mathematics curriculum learning objectives, activities, monitoring procedures and resources for small schools were developed during 1978-79 through the cooperative efforts of 10 Snohomish and Island County school districts, Educational Service District 189 and the Washington State Office of Public Instruction. The objectives were…

  5. 30 CFR 280.29 - Will MMS monitor the environmental effects of my activity?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Will MMS monitor the environmental effects of my activity? 280.29 Section 280.29 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE PROSPECTING FOR MINERALS OTHER THAN OIL, GAS,...

  6. Reciprocal Teaching of Comprehension-Monitoring Activities. Technical Report No. 269.

    ERIC Educational Resources Information Center

    Palincsar, Annemarie Sullivan; Brown, Ann L.

    Three studies were conducted to test the effectiveness of reciprocal teaching as a means of instructing seventh grade poor readers about activities they could use to increase comprehension and to ascertain that their comprehension was proceeding smoothly (comprehension monitoring). Reciprocal teaching involves having teacher and students take…

  7. Quality assurance project plan for ground water monitoring activities managed by Westinghouse Hanford Company. Revision 3

    SciTech Connect

    Stauffer, M.

    1995-11-01

    This quality assurance project plan (QAPP) applies specifically to the field activities and laboratory analysis performed for all RCRA groundwater projects conducted by Hanford Technical Services. This QAPP is generic in approach and shall be implemented in conjunction with the specific requirements of individual groundwater monitoring plans.

  8. High-throughput metabarcoding of eukaryotic diversity for environmental monitoring of offshore oil-drilling activities.

    PubMed

    Lanzén, Anders; Lekang, Katrine; Jonassen, Inge; Thompson, Eric M; Troedsson, Christofer

    2016-09-01

    As global exploitation of available resources increases, operations extend towards sensitive and previously protected ecosystems. It is important to monitor such areas in order to detect, understand and remediate environmental responses to stressors. The natural heterogeneity and complexity of communities means that accurate monitoring requires high resolution, both temporally and spatially, as well as more complete assessments of taxa. Increased resolution and taxonomic coverage is economically challenging using current microscopy-based monitoring practices. Alternatively, DNA sequencing-based methods have been suggested for cost-efficient monitoring, offering additional insights into ecosystem function and disturbance. Here, we applied DNA metabarcoding of eukaryotic communities in marine sediments, in areas of offshore drilling on the Norwegian continental shelf. Forty-five samples, collected from seven drilling sites in the Troll/Oseberg region, were assessed, using the small subunit ribosomal RNA gene as a taxonomic marker. In agreement with results based on classical morphology-based monitoring, we were able to identify changes in sediment communities surrounding oil platforms. In addition to overall changes in community structure, we identified several potential indicator taxa, responding to pollutants associated with drilling fluids. These included the metazoan orders Macrodasyida, Macrostomida and Ceriantharia, as well as several ciliates and other protist taxa, typically not targeted by environmental monitoring programmes. Analysis of a co-occurrence network to study the distribution of taxa across samples provided a framework for better understanding the impact of anthropogenic activities on the benthic food web, generating novel, testable hypotheses of trophic interactions structuring benthic communities.

  9. 40 CFR 35.134 - Eligible recipients.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....134 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Performance Partnership Grants § 35.134 Eligible recipients. (a) Eligible agencies. All State agencies (including environmental, health, agriculture,...

  10. Types of Cancer Associated with Transplant Recipients

    MedlinePlus

    ... normal population. Cancer due to suppression of the immune system Transplant recipients have an increased risk of developing ... growth of white blood cells in the body's immune system. There are several treatment options that will require ...

  11. Adolescent Substance Use with Friends: Moderating and Mediating Effects of Parental Monitoring and Peer Activity Contexts

    PubMed Central

    Kiesner, Jeff; Poulin, François; Dishion, Thomas J.

    2010-01-01

    The influence of using substances with friends on future individual use was examined in the context of parental monitoring rules and the ecology of peer activities. A one-year longitudinal study design included a combined sample of North Italian and French Canadian adolescents (N = 285, 53% girls, M = 14.25 years). Data analyses were conducted using structural equation modeling and multiple regression analyses. As expected, the covariation between parental monitoring and adolescent substance use was mediated by “co-use” with friends. Moreover, the relation between substance use with friends and individual substance use was moderated by parental monitoring rules and the peer activity context. Specifically, the relation between substance co-use with friends and individual substance use was stronger when the level of parental monitoring rules was low and when friends spent their time together primarily in unstructured contexts such as on the street or in park settings. These findings underline the importance of adults’ use of rules to monitor adolescents prone to substance use, and the role of context in facilitating or reducing peer influence. PMID:21165170

  12. Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates

    PubMed Central

    Roest, Mark; Henskens, Yvonne M. C.; de Laat, Bas; Huskens, Dana

    2017-01-01

    Background Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive. We have optimized the flow cytometry-based quantification of agonist induced platelet activation (PACT) to a labor, time and more cost-efficient test. Currently the quality of PCs is only monitored by visual inspection, because available assays are unreliable or too laborious for use in a clinical transfusion laboratory. Therefore, the PACT was applied to monitor PC activation during storage. Study design and methods The optimized PACT was used to monitor 5 PCs during 10 days of storage. In brief, optimized PACT uses a ready-to-use reaction mix, which is stable at -20°C. When needed, a test strip is thawed and platelet activation is initiated by mixing PC with PACT. PACT was based on the following agonists: adenosine diphosphate (ADP), collagen-related peptide (CRP) and thrombin receptor-activating peptide (TRAP-6). Platelet activation was measured as P-selectin expression. Light transmission aggregometry (LTA) was performed as a reference. Results Both PACT and LTA showed platelet function decline during 10-day storage after stimulation with ADP and collagen/CRP; furthermore, PACT showed decreasing TRAP-induced activation. Major differences between the two tests are that PACT is able to measure the status of platelets in the absence of agonists, and it can differentiate between the number of activated platelets and the amount of activation, whereas LTA only measures aggregation in response to an agonist. Also, PACT is more time-efficient compared to LTA and allows high-throughput analysis. Conclusion PACT is an optimized platelet function test that can be used to monitor the activation of PCs. PACT has the same accuracy as LTA with regard to monitoring PCs, but it is superior to both LTA and conventional flow cytometry based tests with regard to labor

  13. The Effect of Social Comparability between Donor and Recipient on Recipient’s Reactions to Aid.

    DTIC Science & Technology

    The results indicate that receiving aid from a social comparison other had a negative effect on the recipient’s situational self - esteem and self ...and hence a threat to self - esteem , when aid is given by a social comparison other. (Author Modified Abstract)...The study explored the effect of social comparability between the donor and the recipient on the recipient’s self -perception and his perception of

  14. PARACOCCIDIOIDOMYCOSIS IN A RENAL TRANSPLANT RECIPIENT

    PubMed Central

    GÓES, Heliana Freitas de Oliveira; DURÃES, Sandra Maria Barbosa; LIMA, Caren dos Santos; de SOUZA, Mariana Boechat; VILAR, Enoi Aparecida Guedes; DALSTON, Marcos Olivier

    2016-01-01

    Paracoccidioidomycosis (PCM) is the most common endemic mycosis in Latin America. The etiological agents, which comprise two species, Paracoccidioides brasiliensis and P. lutzii, are thermodimorphic fungi that usually affect previously healthy adults. They primarily involve the lungs and then disseminate to other organs. Such mycosis is rare in organ transplant recipients; there have been only three cases reported in literature, until now. We report a case of PCM in a renal transplant recipient with an unusual dermatological presentation. PMID:26910451

  15. Devices for Self-Monitoring Sedentary Time or Physical Activity: A Scoping Review

    PubMed Central

    Loveday, Adam; Pearson, Natalie; Edwardson, Charlotte; Yates, Thomas; Biddle, Stuart JH; Esliger, Dale W

    2016-01-01

    Background It is well documented that meeting the guideline levels (150 minutes per week) of moderate-to-vigorous physical activity (PA) is protective against chronic disease. Conversely, emerging evidence indicates the deleterious effects of prolonged sitting. Therefore, there is a need to change both behaviors. Self-monitoring of behavior is one of the most robust behavior-change techniques available. The growing number of technologies in the consumer electronics sector provides a unique opportunity for individuals to self-monitor their behavior. Objective The aim of this study is to review the characteristics and measurement properties of currently available self-monitoring devices for sedentary time and/or PA. Methods To identify technologies, four scientific databases were systematically searched using key terms related to behavior, measurement, and population. Articles published through October 2015 were identified. To identify technologies from the consumer electronic sector, systematic searches of three Internet search engines were also performed through to October 1, 2015. Results The initial database searches identified 46 devices and the Internet search engines identified 100 devices yielding a total of 146 technologies. Of these, 64 were further removed because they were currently unavailable for purchase or there was no evidence that they were designed for, had been used in, or could readily be modified for self-monitoring purposes. The remaining 82 technologies were included in this review (73 devices self-monitored PA, 9 devices self-monitored sedentary time). Of the 82 devices included, this review identified no published articles in which these devices were used for the purpose of self-monitoring PA and/or sedentary behavior; however, a number of technologies were found via Internet searches that matched the criteria for self-monitoring and provided immediate feedback on PA (ActiGraph Link, Microsoft Band, and Garmin Vivofit) and sedentary time

  16. Cost-effective and monitoring-active technique for TDM-passive optical networks

    NASA Astrophysics Data System (ADS)

    Chi, Chang-Chia; Lin, Hong-Mao; Tarn, Chen-Wen; Lin, Huang-Liang

    2014-08-01

    A reliable, detection-active and cost-effective method which employs the hello and heartbeat signals for branched node distinguishing to monitor fiber fault in any branch of distribution fibers of a time division multiplexing passive optical network (TDM-PON) is proposed. With this method, the material cost of building an optical network monitor system for a TDM-PON with 168 ONUs and the time of identifying a multiple branch faults is significantly reduced in a TDM-PON system of any scale. A fault location in a 1 × 32 TDM-PON system using this method to identify the fault branch is demonstrated.

  17. Scour monitoring system of subsea pipeline using distributed Brillouin optical sensors based on active thermometry

    NASA Astrophysics Data System (ADS)

    Zhao, Xue-Feng; Li, Le; Ba, Qin; Ou, Jin-Ping

    2012-10-01

    A scour monitoring system of subsea pipeline is proposed using distributed Brillouin optical sensors based on active thermometry. The system consists in a thermal cable running parallel to the pipeline, which acquires frequency shift of optical sensors during heating and cooling, directly indicating temperature change. The free spans can be detected through the different behaviors of heat transfer between in-water and in-sediment scenarios. Three features were extracted from temperature time histories including magnitude, spatial continuity and temporal stability. Several experimental tests were conducted using the proposed system. The results substantiate the monitoring technique.

  18. Monitoring activities of daily living based on wearable wireless body sensor network.

    PubMed

    Kańtoch, E; Augustyniak, P; Markiewicz, M; Prusak, D

    2014-01-01

    With recent advances in microprocessor chip technology, wireless communication, and biomedical engineering it is possible to develop miniaturized ubiquitous health monitoring devices that are capable of recording physiological and movement signals during daily life activities. The aim of the research is to implement and test the prototype of health monitoring system. The system consists of the body central unit with Bluetooth module and wearable sensors: the custom-designed ECG sensor, the temperature sensor, the skin humidity sensor and accelerometers placed on the human body or integrated with clothes and a network gateway to forward data to a remote medical server. The system includes custom-designed transmission protocol and remote web-based graphical user interface for remote real time data analysis. Experimental results for a group of humans who performed various activities (eg. working, running, etc.) showed maximum 5% absolute error compared to certified medical devices. The results are promising and indicate that developed wireless wearable monitoring system faces challenges of multi-sensor human health monitoring during performing daily activities and opens new opportunities in developing novel healthcare services.

  19. Pilot conversion trial from mycophenolic acid to everolimus in ABO-incompatible kidney-transplant recipients with BK viruria and/or viremia.

    PubMed

    Belliere, Julie; Kamar, Nassim; Mengelle, Catherine; Allal, Asma; Sallusto, Federico; Doumerc, Nicolas; Game, Xavier; Congy-Jolivet, Nicolas; Esposito, Laure; Debiol, Benedicte; Rostaing, Lionel

    2016-03-01

    Immunosuppression using everolimus (EVR) plus low-dose tacrolimus (Tac) is commonly used in organ transplantation. EVR has potential antiviral effects. Herein, the long-term outcomes and impacts of Tac-EVR on the BK virus are reported in ABO-incompatible kidney-transplant recipients. The initial immunosuppressive regimen combined steroids, Tac, and mycophenolic acid (MPA). At a median of 141 (34-529) days post-transplantation, seven stable ABO-incompatible kidney-transplant recipients were converted from MPA to EVR because of active BK replication, and compared with a reference group of fourteen ABO-incompatible patients receiving classical Tac plus MPA. At 1 month before conversion, at 1, 3 months after, and at last follow-up, clinical and biological parameters were monitored. The median time from conversion to the last follow-up was 784 (398-866) days. Conversion to EVR caused no change to rejection episodes or immunological status (isoagglutinin titers, anti-HLA antibodies). At last follow-up, median eGFR was similar in the Tac-MPA versus Tac-EVR group (40 [range: 14-56] vs. 54.5 ml/min/1.73 m(2) [range: 0-128], P = 0.07). The major adverse event was dyslipidemia. Interestingly, conversion from MPA to EVR decreased BK viral load in five patients. ABO-incompatible kidney-transplant recipients with an active BK virus infection may benefit from conversion to EVR.

  20. [Pharmacodynamics of vecuronium in the kidney transplant recipient and the patient with normal renal function].

    PubMed

    Takita, K; Goda, Y; Kawahigashi, H; Okuyama, A; Kubota, M; Kemmotsu, O

    1993-02-01

    Pharmacodynamics of vecuronium were evaluated in seven kidney transplant recipients and compared with seven patients with normal renal function. Vecuronium 0.12 mg.kg-1 was used for the initial dose and 0.03 mg.kg-1 for the second dose for each patient under general anesthesia with either isoflurane, sevoflurane or halothane plus nitrous oxide after induction by thiamylal. The effect of vecuronium was evaluated by a muscle relaxation monitor. The time to the maximum blockade (onset time) and the time of 25% recovery of the first twitch height (duration time) were measured after each administration of vecuronium in patients of both groups. The onset times after the initial and second doses were similar in both groups (180.0 +/- 15.5 sec for recipients versus 185.7 +/- 14.9 sec for patients of normal renal function). However, duration was significantly longer in recipients than in patients of normal renal function. Durations after the initial and second doses were 130 +/- 19 min for the initial dose and 86 +/- 12 min for the second dose in recipients, whereas they were 51 +/- 5 min and 37 +/- 5 min in patients of normal renal function. The prolonged durations of vecuronium in the kidney transplant recipient were speculated to be mainly due to delayed elimination of the drug and effect of cyclosporin, an immunosuppressive agent in the recipients. These results suggest that the titrated administration of vecuronium by keen monitoring of muscle relaxation is needed in the kidney transplant recipient to avoid unnecessary prolongation in duration of action.

  1. 22 CFR 1509.300 - What must I do to comply with this part if I am an individual recipient?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... an individual recipient? 1509.300 Section 1509.300 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are... substance in conducting any activity related to the award; and (b) If you are convicted of a criminal...

  2. 22 CFR 1509.300 - What must I do to comply with this part if I am an individual recipient?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... an individual recipient? 1509.300 Section 1509.300 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are... substance in conducting any activity related to the award; and (b) If you are convicted of a criminal...

  3. 22 CFR 1509.300 - What must I do to comply with this part if I am an individual recipient?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... an individual recipient? 1509.300 Section 1509.300 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are... substance in conducting any activity related to the award; and (b) If you are convicted of a criminal...

  4. THORON-SCOUT - first diffusion based active Radon and Thoron monitor

    NASA Astrophysics Data System (ADS)

    Wagner, W.; Streil, T.; Oeser, V.; Horak, G.; Duzynski, M.

    2016-10-01

    THORON-SCOUT is a stand-alone diffusion based active Radon and Thoron monitor for long term indoor measurements to evaluate the human health risk due to activity concentration in the breathing air. Alpha-particle spectroscopy of Po isotopes, being the progeny of the decay of the radioactive noble gas Radon, is applied to separately monitor activity contributions of 222Rn and 220Rn (Thoron) as well. In this work we show that the portion of Thoron (Tn) may locally be remarkable and even dominating and cannot be neglected as often has been assumed up to now. Along with tobacco consumption, Rn radioactivity turned out to be a dangerous cause of lung cancer, especially in older badly vented buildings situated in regions of radioactive geological formations. THORON-SCOUT allows a precise examination of the indoor atmosphere with respect to Rn and Inactivity concentration and, therefore, a realistic evaluation of corresponding health risk.

  5. Monitoring the Stellar Activity of Transit-Hosting Stars II: supporting HST exoplanet atmosphere observations

    NASA Astrophysics Data System (ADS)

    Wilson, Paul Anthony; Evans, Tom; Sing, David K.; Aigrain, Suzanne

    2012-02-01

    We propose to use the CTIO 1.3m telescope with ANDICAM to monitor 5 bright stars that host transiting exoplanets in an effort to characterise their activity. These observations will provide critical ground-based support for our large HST program that has been granted 124 orbits to perform a survey of UV-optical atmospheric transmission spectra for 8 hot Jupiters using the STIS instrument (Cycle 19, Prog 12473, PI D Sing). They are required because active stellar regions inevitably contaminate measured planetary light curves by causing the apparent planet-to-star radius to vary in a wavelength dependent manner. Regular ground-based photometric monitoring performed using the CTIO 1.3m telescope will allow us to determine the spot activity at the time of the HST observations, so that the stellar baseline flux can be accurately normalised for every transit observed, enabling transmission spectra from multiple visits to be combined.

  6. Using modalmetric fiber optic sensors to monitor the activity of the heart

    NASA Astrophysics Data System (ADS)

    Życzkowski, M.; Uzięblo-Zyczkowska, B.; Dziuda, L.; Różanowski, K.

    2011-03-01

    The paper presents the concept of the modalmetric fiber optic sensor system for human psychophysical activity detection. A fiber optic sensor that utilizes intensity of propagated light to monitor a patient's vital signs such as respiration cardiac activity, blood pressure and body's physical movements. The sensor, which is non-invasive, comprises an multimode fiber proximately situated to the patient so that time varying acusto-mechanical signals from the patient are coupled by the singlemode optical fiber to detector. The system can be implemented in embodiments ranging form a low cost in-home to a high end product for in hospital use. We present the laboratory test of comparing their results with the known methods like EKG. addition, the article describes the work on integrated system to human psychophysiology activity monitoring. That system including a EMFIT, microwave, fiber optic and capacitive sensors.

  7. Acoustic (loudspeaker) facial EMG monitoring: II. Use of evoked EMG activity during acoustic neuroma resection.

    PubMed

    Prass, R L; Kinney, S E; Hardy, R W; Hahn, J F; Lüders, H

    1987-12-01

    Facial electromyographic (EMG) activity was continuously monitored via loudspeaker during eleven translabyrinthine and nine suboccipital consecutive unselected acoustic neuroma resections. Ipsilateral facial EMG activity was synchronously recorded on the audio channels of operative videotapes, which were retrospectively reviewed in order to allow detailed evaluation of the potential benefit of various acoustic EMG patterns in the performance of specific aspects of acoustic neuroma resection. The use of evoked facial EMG activity was classified and described. Direct local mechanical (surgical) stimulation and direct electrical stimulation were of benefit in the localization and/or delineation of the facial nerve contour. Burst and train acoustic patterns of EMG activity appeared to indicate surgical trauma to the facial nerve that would not have been appreciated otherwise. Early results of postoperative facial function of monitored patients are presented, and the possible value of burst and train acoustic EMG activity patterns in the intraoperative assessment of facial nerve function is discussed. Acoustic facial EMG monitoring appears to provide a potentially powerful surgical tool for delineation of the facial nerve contour, the ongoing use of which may lead to continued improvement in facial nerve function preservation through modification of dissection strategy.

  8. Passive acoustic monitoring of biological activity on coral reefs and in nearby waters

    NASA Astrophysics Data System (ADS)

    Lammers, Marc O.; Mooney, T. Aran; Brainard, Russell E.; Au, Whitlow W. L.

    2005-09-01

    Monitoring the changing state of coral reef habitats is a challenging task that is exacerbated when the reefs in question are in remote locations. Physical sensors provide a wide range of measurements of local environmental variables, but do not give an indication of biological activity. The preliminary findings of an effort to use the ambient sound field as a means of characterizing and monitoring biological activity on coral reefs and surrounding waters are reported. Moored recording systems were developed to sample the sound field of reefs on Oahu, Hawaii for 1-min periods, at 30-min intervals, for 10 days at a time. Snapping shrimp produce the dominant acoustic energy on the reefs examined and exhibit clear diel acoustic trends. Peaks in activity consistently occur during crepuscular periods. At frequencies below 2 kHz, many fish sounds occur, which also exhibit distinct temporal variability. Cetacean sounds are also common, indicating the occurrence of an apex predator in the area. Many sounds can be detected automatically, making the examination of the sound field an efficient means of tracking acoustically active species. The results indicate that acoustic monitoring may be an effective means of tracking biological activity at locations where traditional surveys are impractical.

  9. The application of inertial and magnetic sensors to the monitoring of calf muscle pump activity.

    PubMed

    O'Donovan, Karol J; Bourke, Alan K; O'Keeffe, Derek T; Olaighin, Gearóid

    2009-01-01

    On long distance journeys passengers at high risk from deep vein thrombosis (DVT) are recommended to exercise on a regular basis to contract the calf muscle pump and encourage venous return. If a passenger fails to complete an exercise program that induces active contraction of the calf muscle pump they will remain at increased risk of DVT. This paper presents a novel inertial and magnetic sensor-based technique for monitoring calf muscle pump activity. The technique could be implemented into a system for monitoring the level of calf muscle pump activity in persons with limited mobility. Such a system could be used to provide a reminder to the user that there is a need to exercise should they have forgotten to exercise, failed to exercise sufficiently or exercised incorrectly. The proposed technique was evaluated by comparison with calf muscle pump activity measured using an electromyography (EMG) sensor. Results show that the technique can be used to monitor calf muscle pump activity over a wide range of leg exercises.

  10. 14 CFR 1252.300 - General responsibilities of recipients.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false General responsibilities of recipients. 1252.300 Section 1252.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Responsibilities of Recipients § 1252.300 General responsibilities of recipients. Each NASA recipient must...

  11. Physical activity monitoring in obese people in the real life environment

    PubMed Central

    2009-01-01

    Background Obesity is a major problem especially in western countries and several studies underline the importance of physical activity to enhance diet. Currently there is increasing interest in instruments for monitoring daily physical activity. The purpose of this pilot study was to appraise the qualitative and quantitative differences in physical activities and gait analysis parameters in control and obese subjects by means of an innovative tool for the monitoring of physical activity. Methods Twenty-six obese patients, 16 women and 10 men, aged 22 to 69 years with Body Mass Index (BMI) between 30 and 51.4 kg/m2, were compared with 15 control subjects, 4 men and 11 women, aged 24 to 69 with BMI between 18 and 25 kg/m2 during daily physical activities. The IDEEA device (Minisun, Fresno, CA), based on a wearable system of biaxial accelerometers and able to continuously record the physical activities and energy expenditure of a subject in time was used. Time spent in different physical activities such as standing, sitting, walking, lying, reclining, stepping, energy expenditure and gait parameters (velocity, stance duration, etc) were measured during a 24-hours period. Results A trend toward a reduced number of steps was present, associated to reduced speed, reduced cadence and reduced rate of single and double limb support (SLS/DLS). Moreover, obese people spent significant less time stepping, less time lying and more time in a sitting or reclined position during the night. The energy expenditure during a 24-hours period was higher in the obese compared to controls. Conclusions The study provided objective parameters to differentiate the daily motor activity of obese subjects with respect to controls, even a larger population is required to confirm these findings. The device used can be of support in programming educational activities for life style modification in obese people as well as for monitoring the results of various kinds of intervention in these

  12. Recent Advances in Free-Living Physical Activity Monitoring: A Review

    PubMed Central

    Andre, David; Wolf, Donna L.

    2007-01-01

    It has become clear recently that the epidemic of type 2 diabetes sweeping the globe is associated with decreased levels of physical activity and an increase in obesity. Incorporating appropriate and sufficient physical activity into one's life is an essential component of achieving and maintaining a healthy weight and overall health, especially for those with type II diabetes mellitus. Regular physical activity can have a positive impact by lowering blood glucose, helping the body to be more efficient at using insulin. There are other substantial benefits for patients with diabetes, including prevention of cardiovascular disease, hyperlipidemia, hypertension, and obesity. Several complications of utilizing a self-care treatment methodology involving exercise include (1) patients may not know how much activity that they engage in and (2) health-care providers do not have objective measurements of how much activity their patients perform. However, several technological advances have brought a variety of activity monitoring devices to the market that can address these concerns. Ranging from simple pedometers to multisensor devices, the different technologies offer varying levels of accuracy, comfort, and reliability. The key notion is that by providing feedback to the patient, motivation can be increased and targets can be set and aimed toward. Although these devices are not specific to the treatment of diabetes, the importance of physical activity in treating the disease makes an understanding of these devices important. This article reviews these physical activity monitors and describes the advantages and disadvantages of each. PMID:19885145

  13. In situ Raman and X-ray spectroscopies to monitor microbial activities under high hydrostatic pressure.

    PubMed

    Oger, Phil M; Daniel, Isabelle; Picard, Aude

    2010-02-01

    Until recently, monitoring of cells and cellular activities at high hydrostatic pressure (HHP) was mainly limited to ex situ observations. Samples were analyzed prior to and following the depressurization step to evaluate the effect of the pressure treatment. Such ex situ measurements have several drawbacks: (i) it does not allow for kinetic measurements and (ii) the depressurization step often leads to artifactual measurements. Here, we describe recent advances in diamond anvil cell (DAC) technology to adapt it to the monitoring of microbial processes in situ. The modified DAC is asymmetrical, with a single anvil and a diamond window to improve imaging quality and signal collection. Using this novel DAC combined to Raman and X-ray spectroscopy, we monitored the metabolism of glucose by baker's yeast and the reduction of selenite by Agrobacterium tumefaciens in situ under HHP. In situ spectroscopy is also a promising tool to study piezophilic microorganisms.

  14. An Evidence-Based Adoption of Technology Model for Remote Monitoring of Elders’ Daily Activities

    PubMed Central

    2011-01-01

    What benefit will new technologies offer if they are inadequately or not used? This work presents a meta-synthesis of adoption of technology related findings from four innovative monitoring intervention research studies with older adults and their informal and/or formal caregivers. Each study employed mixed methods analyses that lead to an understanding of the key variables that influenced adoption of telephone and Internet based wireless remote monitoring technologies by elders and their caregivers. The studies were all conducted in “real world” homes ranging from solo residences to multi-story independent living residential buildings. Insights gained came from issues not found in controlled laboratory environments but in the complex interplay of family-elder-staff dynamics around balancing safety and independence. Findings resulted in an adoption of technology model for remote monitoring of elders’ daily activities derived from evidence based research to advance both practical and theoretical development in the field of gerontechnology. PMID:21423843

  15. Multisensor fusion for atrial and ventricular activity detection in coronary care monitoring

    PubMed Central

    Hernández, Alfredo I.; Carrault, Guy; Mora, Fernando; Thoraval, Laurent; Passariello, Gianfranco; Schleich, Jean-Marc

    1999-01-01

    Information management for critical care monitoring is still a very difficult task. Medical staff is often overwhelmed by the amount of data provided by the increased number of specific monitoring devices and instrumentation, and the lack of an effective automated system. Specifically, a basic task such as arrhythmia detection still produce an important amount of undesirable alarms, due in part to the mechanistic approach of current monitoring systems. In this work, multi-sensor and multi-source data fusion schemes to improve atrial and ventricular activity detection in critical care environments are presented. Applications of these schemes are quantitatively evaluated and compared with current methods, showing the potential advantages of data fusion techniques for event detection in noise corrupted signals. PMID:10513122

  16. Assessment and Design of Water Quality Monitoring Networks with respect to Shale Gas Activities in Pennsylvania

    NASA Astrophysics Data System (ADS)

    Arjmand, S.; Abad, J. D.; Brantley, S. L.

    2013-12-01

    Over the past few years, hydraulic fracturing and horizontal drilling techniques have been extensively used to extract shale gas from the Marcellus Shale. Likewise, several environmental violations that have been repeatedly reported in drilling sites have created greater awareness on potentially adverse environmental impacts of shale gas. Long-term monitoring in the Marcellus Shale is the key to maintain and improve the quality of water supplies in future. Currently, the absence of an efficient water quality monitoring network prevents the detection and source identification of contaminants associated with shale gas activities. Evaluation and re-design of monitoring networks from time to time is a major step towards efficient water resources planning and management. In this study, we assessed the performance of the current water quality monitoring network with respect to the shale gas development in Pennsylvania. For better evaluation, the Oil and Gas Compliance Report by the Pennsylvania Department of Environmental Protection between January 2005 and May 2013 was compiled. Using statistical and GIS methods each violation item was examined against the number and location of sensors in the current monitoring network. The results helped identify the adequacy of the number of sensors to detect the potential contamination. Moreover, to improve the performance and to lower the long-term monitoring costs, we re-designed the network using optimization methods. This optimal system maximizes the understanding of the aquifer condition and investigates the shale gas industry impacts on shallow aquifers, and it is applicable to other watersheds with shale oil and gas drilling activities.

  17. AVHRR-based drought-observing system for monitoring the environment and socioeconomic activities

    NASA Astrophysics Data System (ADS)

    Kogan, F.

    From all natural disaster, drought is the least understandable and the most damaging environmental phenomenon. Although in pre-satellite era, climate data were used for drought monitoring, drought specifics created problems in early drought detection start/end, monitoring its expansion/contraction, intensity and area coverage and the most important, timely estimation of the impacts on the environment and socioeconomic activities. The latest prevented to take prompt measures in mitigating negative consequences of drought for the society. Advances in remote sensing of the past ten years, contributed to the development of comprehensive drought monitoring system and numerous applications, which helped to make decisions for monitoring the environment and predicting sustainable socioeconomic activities. This paper discusses satellite-based land-surface observing system, which provides wells of information used for monitoring such unusual natural disaster as drought. This system was developed from the observations of the Advanced Very High Resolution Radiometer (AVHRR) flown on NOAA operational polar-orbiting satellites. The AVHRR data were packed into the Global Vegetation Index (GVI) product, which have served the global community since 1981. The GVI provided reflectances and indices (4 km spacial resolution) every seven days for each 16 km map cell between 75EN and 55ES covering all land ecosystems. The data includes raw and calibrated radiances in the visible, near infrared and infrared spectral bands, processed (with eliminated high frequency noise) radiances, normalized difference vegetation index (NDVI), 20-year climatology, vegetation condition indices and also products, such as vegetation health, drought, vegetation fraction, fire risk etc. In the past ten years, users around the world used this information addressing different issues of drought impacts on socioeconomic activities and responded positively to real time drought information place regularly on the

  18. Automated swimming activity monitor for examining temporal patterns of toxicant effects on individual Daphnia magna.

    PubMed

    Bahrndorff, Simon; Michaelsen, Thomas Yssing; Jensen, Anne; Marcussen, Laurits Faarup; Nielsen, Majken Elley; Roslev, Peter

    2016-07-01

    Aquatic pollutants are often biologically active at low concentrations and impact on biota in combination with other abiotic stressors. Traditional toxicity tests may not detect these effects, and there is a need for sensitive high-throughput methods for detecting sublethal effects. We have evaluated an automated infra-red (IR) light-based monitor for recording the swimming activity of Daphnia magna to establish temporal patterns of toxicant effects on an individual level. Activity was recorded for 48 h and the sensitivity of the monitor was evaluated by exposing D. magna to the reference chemicals K2 Cr2 O7 at 15, 20 and 25 °C and 2,4-dichlorophenol at 20 °C. Significant effects (P < 0.001) of toxicant concentrations, exposure time and incubation temperatures were observed. At 15 °C, the swimming activity remained unchanged for 48 h at sublethal concentrations of K2 Cr2 O7 whereas activity at 20 and 25 °C was more biphasic with decreases in activity occurring after 12-18 h. A similar biphasic pattern was observed after 2,4-dichlorophenol exposure at 20 °C. EC50 values for 2,4-dichlorophenol and K2 Cr2 O7 determined from automated recording of swimming activity showed increasing toxicity with time corresponding to decreases in EC50 of 0.03-0.07 mg l(-1) h(-1) . EC50 values determined after 48 h were comparable or lower than EC50 values based on visual inspection according to ISO 6341. The results demonstrated that the swimming activity monitor is capable of detecting sublethal behavioural effects that are toxicant and temperature dependent. The method allows EC values to be established at different time points and can serve as a high-throughput screening tool in toxicity testing. Copyright © 2015 John Wiley & Sons, Ltd.

  19. Recent Developments in Active and Passive Distributed Temperature Sensing for Soil Moisture Monitoring

    NASA Astrophysics Data System (ADS)

    Steele-Dunne, S. C.; Dong, J.; Hoes, O.; Van De Giesen, N.; Sayde, C.; Ochsner, T. E.; Selker, J. S.

    2015-12-01

    In this presentation we will review recent developments in both active and passive Distributed Temperature Sensing (DTS) for soil moisture monitoring. DTS involves using fiber-optic cables to measure temperature at sub-meter resolution along cables up to several kilometers in length. Soil thermal properties depend on soil moisture. Hence, temperature variations either in response to externally-applied heating (active) or the response to net radiation (passive) can be monitored and used to infer soil moisture. DTS occupies a unique measurement niche, potentially providing soil moisture information at sub-meter resolution over extents on the order of km at sub-daily time steps. It complements observations from point sensors to other innovative measurement techniques like cosmic ray neutron detection methods and GPS reflectometry. DTS is being developed as a tool for the validation of soil moisture observations from remote sensing and for hydrological field investigations. Here, we will discuss both technological and theoretical advances in active and passive DTS for soil moisture monitoring. We will present data from new installations in the Netherlands and the USA to illustrate recent developments. In particular, we will focus on the value of combining temperature observations from DTS with physical models using data assimilation. In addition to yielding improved soil moisture and temperature profile estimates, recent research has shown the potential to also derive information on the soil thermal and hydraulic properties. We will conclude by outlining the current challenges, with particular emphasis on combining active and passive DTS.

  20. Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks.

    PubMed

    Pinti, Paola; Aichelburg, Clarisse; Lind, Frida; Power, Sarah; Swingler, Elizabeth; Merla, Arcangelo; Hamilton, Antonia; Gilbert, Sam; Burgess, Paul; Tachtsidis, Ilias

    2015-12-02

    Functional Near Infrared Spectroscopy (fNIRS) is a neuroimaging technique that uses near-infrared light to monitor brain activity. Based on neurovascular coupling, fNIRS is able to measure the haemoglobin concentration changes secondary to neuronal activity. Compared to other neuroimaging techniques, fNIRS represents a good compromise in terms of spatial and temporal resolution. Moreover, it is portable, lightweight, less sensitive to motion artifacts and does not impose significant physical restraints. It is therefore appropriate to monitor a wide range of cognitive tasks (e.g., auditory, gait analysis, social interaction) and different age populations (e.g., new-borns, adults, elderly people). The recent development of fiberless fNIRS devices has opened the way to new applications in neuroscience research. This represents a unique opportunity to study functional activity during real-world tests, which can be more sensitive and accurate in assessing cognitive function and dysfunction than lab-based tests. This study explored the use of fiberless fNIRS to monitor brain activity during a real-world prospective memory task. This protocol is performed outside the lab and brain haemoglobin concentration changes are continuously measured over the prefrontal cortex while the subject walks around in order to accomplish several different tasks.

  1. Memory monitoring performance and PFC activity are associated with 5-HTTLPR genotype in older adults

    PubMed Central

    Pacheco, Jennifer; Beevers, Christopher G.; McGeary, John E.; Schnyer, David M.

    2012-01-01

    Older adults show extensive variability in cognitive performance, including episodic memory. A portion of this variability could potentially be explained by genetic factors. Recent literature shows that the neurotransmitter serotonin plays an important role in memory processes, as enhancements of brain serotonin have led to memory improvement. Here, we have begun to explore genetic contributions to the performance and underlying brain activity associated with source memory monitoring. Using a source recognition memory task during fMRI scanning, this study offers evidence that older adults who carry a short allele (S-car) of the serotonin transporter linked polymorphic region (5-HTTLPR) in the SLC6A4 gene show specific deficits in source memory monitoring relative to older adults who are homozygous for the long allele (LL). These deficits are accompanied by less neural activity in regions of prefrontal cortex that have been shown to support accurate memory monitoring. Moreover, while the older adult LL group’s behavioral performance does not differ from younger adults, their brain activation reveals evidence of compensatory activation that likely supports their higher performance level. These results provide preliminary evidence that the long-allele homozygous profile is cognitively beneficial to older adults, particularly for memory functioning. PMID:22705442

  2. Using Fiberless, Wearable fNIRS to Monitor Brain Activity in Real-world Cognitive Tasks

    PubMed Central

    Pinti, Paola; Aichelburg, Clarisse; Lind, Frida; Power, Sarah; Swingler, Elizabeth; Merla, Arcangelo; Hamilton, Antonia; Gilbert, Sam; Burgess, Paul; Tachtsidis, Ilias

    2015-01-01

    Functional Near Infrared Spectroscopy (fNIRS) is a neuroimaging technique that uses near-infrared light to monitor brain activity. Based on neurovascular coupling, fNIRS is able to measure the haemoglobin concentration changes secondary to neuronal activity. Compared to other neuroimaging techniques, fNIRS represents a good compromise in terms of spatial and temporal resolution. Moreover, it is portable, lightweight, less sensitive to motion artifacts and does not impose significant physical restraints. It is therefore appropriate to monitor a wide range of cognitive tasks (e.g., auditory, gait analysis, social interaction) and different age populations (e.g., new-borns, adults, elderly people). The recent development of fiberless fNIRS devices has opened the way to new applications in neuroscience research. This represents a unique opportunity to study functional activity during real-world tests, which can be more sensitive and accurate in assessing cognitive function and dysfunction than lab-based tests. This study explored the use of fiberless fNIRS to monitor brain activity during a real-world prospective memory task. This protocol is performed outside the lab and brain haemoglobin concentration changes are continuously measured over the prefrontal cortex while the subject walks around in order to accomplish several different tasks. PMID:26651025

  3. Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

    PubMed Central

    Tatem, Kathleen S.; Quinn, James L.; Phadke, Aditi; Yu, Qing; Gordish-Dressman, Heather; Nagaraju, Kanneboyina

    2014-01-01

    The open field activity monitoring system comprehensively assesses locomotor and behavioral activity levels of mice. It is a useful tool for assessing locomotive impairment in animal models of neuromuscular disease and efficacy of therapeutic drugs that may improve locomotion and/or muscle function. The open field activity measurement provides a different measure than muscle strength, which is commonly assessed by grip strength measurements. It can also show how drugs may affect other body systems as well when used with additional outcome measures. In addition, measures such as total distance traveled mirror the 6 min walk test, a clinical trial outcome measure. However, open field activity monitoring is also associated with significant challenges: Open field activity measurements vary according to animal strain, age, sex, and circadian rhythm. In addition, room temperature, humidity, lighting, noise, and even odor can affect assessment outcomes. Overall, this manuscript provides a well-tested and standardized open field activity SOP for preclinical trials in animal models of neuromuscular diseases. We provide a discussion of important considerations, typical results, data analysis, and detail the strengths and weaknesses of open field testing. In addition, we provide recommendations for optimal study design when using open field activity in a preclinical trial. PMID:25286313

  4. Physical Activities Monitoring Using Wearable Acceleration Sensors Attached to the Body.

    PubMed

    Arif, Muhammad; Kattan, Ahmed

    2015-01-01

    Monitoring physical activities by using wireless sensors is helpful for identifying postural orientation and movements in the real-life environment. A simple and robust method based on time domain features to identify the physical activities is proposed in this paper; it uses sensors placed on the subjects' wrist, chest and ankle. A feature set based on time domain characteristics of the acceleration signal recorded by acceleration sensors is proposed for the classification of twelve physical activities. Nine subjects performed twelve different types of physical activities, including sitting, standing, walking, running, cycling, Nordic walking, ascending stairs, descending stairs, vacuum cleaning, ironing clothes and jumping rope, and lying down (resting state). Their ages were 27.2 ± 3.3 years and their body mass index (BMI) is 25.11 ± 2.6 Kg/m2. Classification results demonstrated a high validity showing precision (a positive predictive value) and recall (sensitivity) of more than 95% for all physical activities. The overall classification accuracy for a combined feature set of three sensors is 98%. The proposed framework can be used to monitor the physical activities of a subject that can be very useful for the health professional to assess the physical activity of healthy individuals as well as patients.

  5. Development of a real time activity monitoring Android application utilizing SmartStep.

    PubMed

    Hegde, Nagaraj; Melanson, Edward; Sazonov, Edward

    2016-08-01

    Footwear based activity monitoring systems are becoming popular in academic research as well as consumer industry segments. In our previous work, we had presented developmental aspects of an insole based activity and gait monitoring system-SmartStep, which is a socially acceptable, fully wireless and versatile insole. The present work describes the development of an Android application that captures the SmartStep data wirelessly over Bluetooth Low energy (BLE), computes features on the received data, runs activity classification algorithms and provides real time feedback. The development of activity classification methods was based on the the data from a human study involving 4 participants. Participants were asked to perform activities of sitting, standing, walking, and cycling while they wore SmartStep insole system. Multinomial Logistic Discrimination (MLD) was utilized in the development of machine learning model for activity prediction. The resulting classification model was implemented in an Android Smartphone. The Android application was benchmarked for power consumption and CPU loading. Leave one out cross validation resulted in average accuracy of 96.9% during model training phase. The Android application for real time activity classification was tested on a human subject wearing SmartStep resulting in testing accuracy of 95.4%.

  6. Physical Activities Monitoring Using Wearable Acceleration Sensors Attached to the Body

    PubMed Central

    2015-01-01

    Monitoring physical activities by using wireless sensors is helpful for identifying postural orientation and movements in the real-life environment. A simple and robust method based on time domain features to identify the physical activities is proposed in this paper; it uses sensors placed on the subjects’ wrist, chest and ankle. A feature set based on time domain characteristics of the acceleration signal recorded by acceleration sensors is proposed for the classification of twelve physical activities. Nine subjects performed twelve different types of physical activities, including sitting, standing, walking, running, cycling, Nordic walking, ascending stairs, descending stairs, vacuum cleaning, ironing clothes and jumping rope, and lying down (resting state). Their ages were 27.2 ± 3.3 years and their body mass index (BMI) is 25.11 ± 2.6 Kg/m2. Classification results demonstrated a high validity showing precision (a positive predictive value) and recall (sensitivity) of more than 95% for all physical activities. The overall classification accuracy for a combined feature set of three sensors is 98%. The proposed framework can be used to monitor the physical activities of a subject that can be very useful for the health professional to assess the physical activity of healthy individuals as well as patients. PMID:26203909

  7. A Miniature-Implantable RF-Wireless Active Glaucoma Intraocular Pressure Monitor.

    PubMed

    Chow, Eric Y; Chlebowski, Arthur L; Irazoqui, Pedro P

    2010-12-01

    Glaucoma is a detrimental disease that causes blindness in millions of people worldwide. There are numerous treatments to slow the condition but none are totally effective and all have significant side effects. Currently, a continuous monitoring device is not available, but its development may open up new avenues for treatment. This work focuses on the design and fabrication of an active glaucoma intraocular pressure (IOP) monitor that is fully wireless and implantable. Major benefits of an active IOP monitoring device include the potential to operate independently from an external device for extended periods of time and the possibility of developing a closed-loop monitoring and treatment system. The fully wireless operation is based off using gigahertz-frequency electromagnetic wave propagation, which allows for an orientation independent transfer of power and data over reasonable distances. Our system is comprised of a micro-electromechanical systems (MEMS) pressure sensor, a capacitive power storage array, an application-specific integrated circuit designed on the Texas Instruments (TI) 130 nm process, and a monopole antenna all assembled into a biocompatible liquid-crystal polymer-based tadpole-shaped package.

  8. An automatic continuous monitoring station for groundwater geochemistry at an active fault zone in SW Taiwan

    NASA Astrophysics Data System (ADS)

    Lai, Chun-Wei; Yang, Tsanyao F.; Fu, Ching-Chou; Hilton, David R.; Liu, Tsung-Kwei; Walia, Vivek; Lai, Tzu-Hua

    2015-04-01

    Previous studies have revealed that gas compositions of fluid samples collected from southwestern Taiwan where many hot springs and mud volcanoes are distributed along tectonic sutures show significant variation prior to and after some disaster seismic events. Such variations, including radon activity, CH4/CO2, CO2/3He and 3He/4He ratios of gas compositions, are considered to be precursors of earthquakes in this area. To validate the relationship between fluid compositions and local earthquakes, a continuous monitoring station has been established at Yun-Shui, which is an artesian well located at an active fault zone in SW Taiwan. It is equipped with a radon detector and a quadrupole mass spectrometer (QMS) for in-situ measurement of the dissolved gas composition. Data is telemetered to Taipei so we are able to monitor variations of gas composition in real time. Furthermore, we also installed a syringe pump apparatus for the retrieval and temporal analysis of helium (SPARTAH) at this station. From the SPARTAH samples, we can obtain detailed time series records of H-O isotopic compositions, DIC concentration and δ13C isotopic ratios, and anion concentration of the water samples at this station. After continuous monitoring for about one year, some anomalies occurred prior to some local earthquakes. It demonstrates that this automated system is feasible for long-term continuous seismo-geochemical research in this area. Keywords: monitoring; geochemistry; isotope; dissolved gases; pre-seismic signal.

  9. Engineering the development of systems for multisensory monitoring and activity interpretation

    NASA Astrophysics Data System (ADS)

    Gascueña, José Manuel; Castillo, José Carlos; Navarro, Elena; Fernández-Caballero, Antonio

    2014-04-01

    Multisensory monitoring and activity interpretation systems are being increasingly used as a suitable means to detect situations and make decisions in an intelligent manner. However, there is a lack of formalised processes that guide the stakeholders in their development. Most of the current proposals focus on the implementation and evaluation of low-level algorithms. In order to overcome this lack, a process called INT3-SDP that guides stakeholders in the development of systems capable of carrying out multisensory monitoring and INTerpretation of behaviours and situations for an INTelligent INTervention in complex and dynamic environments is described in this paper. In this work, it is described how INT3-SDP provides the analysts with the guidelines and models necessary for the description of the environment to be monitored and the sensors to be installed, as well as in the implementation of the software components that perform the monitoring and activity interpretation tasks. Moreover, a case study is also presented in order to illustrate how INT3-SDP is put into practice.

  10. Treatment of solid organ transplant recipients with autologous Epstein Barr virus–specific cytotoxic T lymphocytes (CTLs)

    PubMed Central

    Savoldo, Barbara; Goss, John A.; Hammer, Markus M.; Zhang, Lan; Lopez, Teresita; Gee, Adrian P.; Lin, Yu-Feng; Quiros-Tejeira, Ruben E.; Reinke, Petra; Schubert, Stephan; Gottschalk, Stephen; Finegold, Milton J.; Brenner, Malcolm K.; Rooney, Cliona M.; Heslop, Helen E.

    2006-01-01

    We have investigated the in vivo safety, efficacy, and persistence of autologous Epstein Barr virus (EBV)–specific cytotoxic T lymphocytes (CTLs) for the treatment of solid organ transplant (SOT) recipients at high risk for EBV-associated posttransplantation lymphoproliferative disease (PTLD). EBV-CTLs generated from 35 patients expanded with normal kinetics contained both CD8 and CD4 lymphocytes and produced significant specific killing of autologous EBV-transformed B lymphoblastoid cell lines (LCLs). Twelve SOT recipients at high risk for PTLD, or with active disease, received autologous CTL infusions without toxicity. Real-time polymerase chain reaction (PCR) monitoring of EBV-DNA showed a transient increase in plasma EBV-DNA suggestive of lysis of EBV-infected cells, although there was no consistent decrease in virus load in peripheral-blood mononuclear cells. Interferon-γ enzyme-linked immunospot (ELISPOT) assay and tetramer analysis showed an increase in the frequency of EBV-responsive T cells, which returned to preinfusion levels after 2 to 6 months. None of the treated patients developed PTLD. One patient with liver PTLD showed a complete response, and one with ocular disease has had a partial response stable for over one year. These data are consistent with an expansion and persistence of adoptively transferred EBV-CTLs that is limited in the presence of continued immunosuppression but that nonetheless produces clinically useful antiviral activity. PMID:16835376

  11. Active and passive electrical and seismic time-lapse monitoring of earthen embankments

    NASA Astrophysics Data System (ADS)

    Rittgers, Justin Bradley

    In this dissertation, I present research involving the application of active and passive geophysical data collection, data assimilation, and inverse modeling for the purpose of earthen embankment infrastructure assessment. Throughout the dissertation, I identify several data characteristics, and several challenges intrinsic to characterization and imaging of earthen embankments and anomalous seepage phenomena, from both a static and time-lapse geophysical monitoring perspective. I begin with the presentation of a field study conducted on a seeping earthen dam, involving static and independent inversions of active tomography data sets, and self-potential modeling of fluid flow within a confined aquifer. Additionally, I present results of active and passive time-lapse geophysical monitoring conducted during two meso-scale laboratory experiments involving the failure and self-healing of embankment filter materials via induced vertical cracking. Identified data signatures and trends, as well as 4D inversion results, are discussed as an underlying motivation for conducting subsequent research. Next, I present a new 4D acoustic emissions source localization algorithm that is applied to passive seismic monitoring data collected during a full-scale embankment failure test. Acoustic emissions localization results are then used to help spatially constrain 4D inversion of collocated self-potential monitoring data. I then turn to time-lapse joint inversion of active tomographic data sets applied to the characterization and monitoring of earthen embankments. Here, I develop a new technique for applying spatiotemporally varying structural joint inversion constraints. The new technique, referred to as Automatic Joint Constraints (AJC), is first demonstrated on a synthetic 2D joint model space, and is then applied to real geophysical monitoring data sets collected during a full-scale earthen embankment piping-failure test. Finally, I discuss some non-technical issues related to

  12. Algorithm of clinical protocol lowering the risk of systemic Mycosis infections in allografts recipients.

    PubMed

    Swoboda-Kopec, E; Netsvyetayeva, I; Paczek, L; Dabkowska, M; Kwiatkowski, A; Jaworska-Zaremba, M; Mierzwinska-Nastalska, E; Sikora, M; Blachnio, S; Mlynarczyk, G; Fiedor, P

    2009-10-01

    The aim of the study was to describe a diagnostic protocol to lower the risk of a mycotic invasive infection among allotransplant recipients and to suggest the use of preoperative prophylaxis and/or empiric therapy. We chose a group of 268 allograft recipients with transient or constant yeast colonization or confirmed yeast infection. Among 7744 clinical samples, 475 were positive for fungi. We used conventional fungal laboratory diagnosis, enzymatic activity tests, serologic tests, molecular diagnosis of samples from sterile body sites, and histopathologic examinations. The following clinical samples were examined: blood samples; swabs from mouth lesions, throat, and rectum; and sputum, urine, and fecal samples from kidney transplant recipients and simultaneous pancreas-kidney transplantation recipients who are highly predisposed to mycotic infections. We established microbiologic criteria of a systemic mycosis and principles to distinguish colonization from infection.

  13. Small-molecule FRET probes for protein kinase activity monitoring in living cells

    SciTech Connect

    Vaasa, Angela; Lust, Marje; Terrin, Anna; Uri, Asko; Zaccolo, Manuela

    2010-07-09

    In this study, the applicability of fluorescently labeled adenosine analogue-oligoarginine conjugates (ARC-Photo probes) for monitoring of protein kinase A (PKA) activity in living cells was demonstrated. ARC-Photo probes possessing subnanomolar affinity towards the catalytic subunit of PKA (PKAc) and competitive with the regulatory subunit (PKAr), penetrate cell plasma membrane and associate with PKAc fused with yellow fluorescent protein (PKAc-YFP). Detection of inter-molecular Foerster resonance energy transfer (FRET) efficiency between the fluorophores of the fusion protein and ARC-Photo probe can be used for both the evaluation of non-labeled inhibitors of PKAc and for monitoring of cAMP signaling via detection of changes in the activity of PKA as a cAMP downstream effector.

  14. Chromosomally integrated human herpesvirus-6 in transplant recipients.

    PubMed

    Lee, S-O; Brown, R A; Razonable, R R

    2012-08-01

    Human herpesvirus-6 (HHV-6) is unique among human herpesviruses because of its ability to integrate into chromosomes. This entity, termed chromosomally integrated HHV-6 (CIHHV-6), is often mistaken for active infection and treated unnecessarily. The clinical significance of CIHHV-6 in transplant recipients is not defined. Herein, the clinical characteristics of 7 liver transplant patients with CIHHV-6 from our recent study, together with 14 other published cases of CIHHV-6 were reviewed. Of the 21 cases, CIHHV-6B was reported most commonly among solid organ transplant recipients, while CIHHV-6A was mostly seen in allogeneic hematopoietic stem cell recipients. None of the 21 patients developed clinical symptoms related to HHV-6 after transplantation. However, antiviral therapy was administered to 5 asymptomatic patients mistaken to have HHV-6 infection because of their very high HHV-6 DNA levels, 3 who developed symptomatic cytomegalovirus disease, and 1 with graft-versus-host disease that was mistaken for HHV-6 infection. In patients who received antiviral therapy, there was no apparent decline in HHV-6 DNA load, although change in viral kinetics is difficult to discern in the setting of high baseline HHV-6 DNA load. Clinicians should be aware of this entity of CIHHV-6 so that antiviral therapy can be considered in the proper clinical context.

  15. Apoptosis and hepatitis C virus infection in renal transplant recipients.

    PubMed

    Delladetsima, Ioanna; Psichogiou, Mina; Alexandrou, Paraskevi; Nikolopoulos, George; Revenas, Kostantinos; Hatzakis, Angelos; Boletis, John

    2008-05-01

    Hepatocellular injury in renal transplant recipients with hepatitis C virus (HCV) infection remains unclear. The suppressed immune response, in combination with increased viremia levels, provides a unique setting for the study of a potential HCV-induced apoptotic process. Liver biopsy specimens from 59 HCV-infected renal transplant recipients were examined histologically. DNA fragmentation was detected by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-nick end labeling assay, and the CD8 T-cell count was assessed immunohistochemically.A low apoptotic index (0-2.5) was observed in 31 cases, a moderate index (2.6-5) in 16, and a high index (>5) in 12. Apoptotic cell death correlated significantly with viremia because it was demonstrated by higher HCV-RNA levels in cases with a high number of apoptotic cells (odds ratio, 2.96; 95% confidence interval, 1.0-8.5; P = .04). No correlation was found between the apoptotic index and hepatitis necroinflammatory activity, CD8 cell count, fibrosis stage, immunosuppressive therapy, or genotype. In HCV-infected renal transplant recipients, apoptotic cell death seems to be associated with high viral load, thus providing indications of viral interference in the pathogenetic process.

  16. Effects of passive computer use time and non-computer work time on the performance of electronic activity monitoring.

    PubMed

    Hwang, Yaw-Huei; Chen, Yen-Ting; Yeh, Jao-Yu; Liang, Huey-Wen

    2010-10-01

    This study aimed to examine the effects of passive and non-computer work time on the estimation of computer use times by electronic activity monitoring. A total of 20 subjects with computers were monitored for 3 h. Average relative error for total computer use time estimation was about 4%, given that non-computer work time was 20% of the 3-h monitored period. No significant impact of passive computer use time was found in this study. Non-computer work time of 40% or less is suggested as criteria for the application of electronic activity monitoring to ensure reliability in the physical work loading assessment. Statement of Relevance: This research studied the criteria of non-computer work time for the appropriate use of electronic activity monitoring to ensure reliability in the assessment of physical work loading. It is suggested that it should be set to 40% or less of the 3-h monitoring period.

  17. An Overview of Recent Geostationary Fire Monitoring Activities and Applications in the Western Hemisphere

    NASA Astrophysics Data System (ADS)

    McRae, D. J.; Conard, S. G.; Ivanova, G. A.; Sukhinin, A. I.; Hao, W. M.; Koutzenogii, K. P.; Prins, E. M.; Schmidt, C. C.; Feltz, J. M.

    2002-05-01

    Over the past twenty years the international scientific research and environmental monitoring communities have recognized the vital role environmental satellites can play in detecting and monitoring active fires both regionally and around the globe for hazards applications and to better understand the extent and impact of biomass burning on the global environment. Both groups have stressed the importance of utilizing operational satellites to produce routine fire products and to ensure long-term stable records of fire activity for applications such as land-use/land cover change analyses and global climate change research. The current NOAA GOES system provides the unique opportunity to detect fires throughout the Western Hemisphere every half-hour from a series of nearly identical satellites for a period of 15+ years. This presentation will provide an overview of the GOES biomass burning monitoring program at UW-Madison Cooperative Institute for Meteorological Satellite Studies (CIMSS) with an emphasis on recent applications of the new GOES Wildfire Automated Biomass Burning Algorithm (WF_ABBA). For the past 8 years, CIMSS has utilized the GOES-8 imager to monitor biomass burning trends in South America. Since September 2000, CIMSS has been producing half-hourly fire products in real-time for most of the Western Hemisphere. The WF_ABBA half-hourly fire product is providing new insights into diurnal, spatial, seasonal and interannual fire dynamics in North, Central, and South America. In North America these products are utilized to detect and monitor wildfires in northerly and remote locations. In South America the diurnal GOES fire product is being used as an indicator of land-use and land-cover change and carbon dynamics along the borders between Brazil, Peru, and Bolivia. The Navy is assimilating the Wildfire ABBA fire product into the Navy Aerosol Analysis and Prediction System (NAAPS) to analyze and predict aerosol loading and transport as part of the NASA

  18. Effect of wrist-worn activity monitor feedback on physical activity behavior: A randomized controlled trial in Finnish young men

    PubMed Central

    Jauho, Anna-Maiju; Pyky, Riitta; Ahola, Riikka; Kangas, Maarit; Virtanen, Paula; Korpelainen, Raija; Jämsä, Timo

    2015-01-01

    The purpose of this study is to evaluate whether the use of an activity monitor providing feedback has an effect on physical activity (PA) in young men. A population-based sample of 276 conscription-aged (mean = 17.9, SD = 0.7 years) men participated in a 3-month randomized controlled trial in Oulu in 2012. Participants were randomized to an intervention group (INT, N = 137) and a control group (CON, N = 139). INT received a wrist-worn monitor (Polar Active) showing daily activity, and CON received identical monitors without feedback. Main outcome was the change from baseline in objectively measured weekly time spent in moderate-to-vigorous PA (MVPA) and sedentary activity (SED), as assessed by generalized estimation equations (GEE). Other lifestyle factors were assessed by a questionnaire at baseline and at 3 months. Weekly physical activity data (≥ 4 days with ≥ 8 h each) were obtained from 72 (53%) and 90 (65%) men in the INT and CON, respectively. Based on GEE, time spent in MVPA increased (p = 0.012) and SED decreased (p = 0.032) in the INT compared with the CON. During the first 7 weeks, the INT spent on average 1 h less sedentary than the CON (t-test, p < 0.05). During the first week, the INT showed 12 minutes more MVPA compared to the CON (t-test, p = 0.034). Based on questionnaire data, the proportion of the most sedentary men decreased in the INT (Wilcoxon test, 28% vs. 10%, p = 0.029), with no change in the CON (20% vs. 19%, p = 0.546). To conclude, a wrist-worn activity monitor providing feedback had a short-term positive effect on PA and SED in young men. Trial registration This is a pilot study for a larger randomized controlled trial registered to the clinical trials register NCT01376986. PMID:26844128

  19. Skin cancer education in transplant recipients.

    PubMed

    Feuerstein, Ilana; Geller, Alan C

    2008-12-01

    In the past 20 years, long-term survival for solid-organ transplant recipients has improved dramatically; about 223,000 patients are alive in the United States with organ transplants today. As survival rates improve, however, the morbidity and mortality associated with lifelong immunosuppressive therapy is increasing in significance. Skin cancer is common among recipients of all major organ transplants, including the kidney, liver, heart, lung, and pancreas. Although skin cancer is the most common cancer in transplant recipients, many cases can be prevented by sun protection, skin self-examinations, and physician examinations. Because transplant recipients visit the transplant clinic frequently, clinicians have ample opportunities to teach patients about the importance of prevention and detection of skin cancer. At a routine visit, the clinician should inquire about sun protection practices, especially for tanned, light-skinned, or freckled patients or patients who are planning a warm-weather vacation or time in the sun during the summer. Skin cancer education should be integrated into the care of transplant patients as part of their numerous visits to the transplant clinic. Although some transplant recipients may resist adopting new behaviors at first, use of the ample clinic opportunities for patient education can dramatically reduce their risk of skin cancer.

  20. [Short-term use of rapamycin combined with Tregs prolongs mouse cardiac graft survival but attenuates recipient's anti-tumor immunity].

    PubMed

    Yan, Ting; Luo, Chen; Yang, Xianmo; Ji, Lei; Luo, Shiqiao

    2017-02-01

    Objective To study the effect of short-term use of rapamycin(Rap) combined with regulatory T cells (Tregs) on the long-time survival of allogeneic mouse cardiac transplant, and its impact on the anti-tumor immunity of recipient. MethodsMouse Tregs were purified from recipients' spleen by magnetic activated cell sorting (MACS), and expanded by CD3/CD28 monoclonal antibody immunomagnetic beads and 2000 U/mL recombinant mouse IL-2 (rmIL-2) ex vivo. The purity was tested by fluorescence-activated cell sorting (FACS). Allogeneic mouse cardiac transplanted models were established (H-2(b) to H-2(d)), and the mice were divided into three groups: control group (transplant only), Rap group, and Rap combined with Tregs group. In the Rap group, the mice were treated with Rap [1 mg/(kg.d), ip] for 14 consecutive days, and the mice in the Rap plus Tregs group received the same treatment, and 1×10(7) Tregs were adoptively transferred through the tail vein on the day of transplantion. Meanwhile, the syngeneic transplanted group was set up (H-2(d) to H-2(d)). Allograft survival was monitored daily and the graft was harvested on the indicated day and histologically evaluated. In the experiment of recipient's anti-tumor immunity, the similar three groups of allogeneic cardiac transplanted models were established (H-2(b) to H-2(d)), and B16-F10 cells (recipient derived ) were transferred through the tail vein, another three groups of allogeneic cardiac transplanted mice (H-2(d) to H-2(b)) were also transferred with B16-F10 cells (donor derived). Two weeks later, the tumor nodules of the lung were compared. Results The median survival time (MST) of the graft was 7 days in the control group, 15 days in the Rap group, and 93 days in the Rap combined with Tregs group. Histologic analysis of long-time survival grafts showed lymphocyte infiltration and chronic vasculopathy. For donor-derived tumor, there was no tumor nodule in the control group, and tumor nodules significantly increased to

  1. Increasing trend of wearables and multimodal interface for human activity monitoring: A review.

    PubMed

    Kumari, Preeti; Mathew, Lini; Syal, Poonam

    2017-04-15

    Activity recognition technology is one of the most important technologies for life-logging and for the care of elderly persons. Elderly people prefer to live in their own houses, within their own locality. If, they are capable to do so, several benefits can follow in terms of society and economy. However, living alone may have high risks. Wearable sensors have been developed to overcome these risks and these sensors are supposed to be ready for medical uses. It can help in monitoring the wellness of elderly persons living alone by unobtrusively monitoring their daily activities. The study aims to review the increasing trends of wearable devices and need of multimodal recognition for continuous or discontinuous monitoring of human activity, biological signals such as Electroencephalogram (EEG), Electrooculogram (EOG), Electromyogram (EMG), Electrocardiogram (ECG) and parameters along with other symptoms. This can provide necessary assistance in times of ominous need, which is crucial for the advancement of disease-diagnosis and treatment. Shared control architecture with multimodal interface can be used for application in more complex environment where more number of commands is to be used to control with better results in terms of controlling.

  2. A label-free bioluminescent sensor for real-time monitoring polynucleotide kinase activity.

    PubMed

    Du, Jiao; Xu, Qinfeng; Lu, Xiaoquan; Zhang, Chun-yang

    2014-08-19

    Polynucleotide kinase (PNK) plays a crucial role in maintaining the genomic stability of cells and is becoming a potential target in the radio-therapeutic treatment of cancers. The fluorescent method is usually used to measure the PNK activity, but it is impossible to obtain the real-time monitoring without the employment of the labeled DNA probes. Here, we report a label-free bioluminescent sensor for PNK activity assay through real-time monitoring of the phosphorylation-dependent DNA ligation reaction. In this bioluminescent sensor, two hairpin DNA probes with 5'-protruding terminal are designed as the phosphate acceptor, and the widely used phosphate donor of ATP is substituted by dCTP. In the absence of PNK, the ligation reaction cannot be triggered due to the lack of 5'-phosphoryl groups in the probes, and the background signal is negligible. With the addition of PNK, the phosphorylation-ligation reaction of the probes is initiated with the release of AMP, and the subsequent conversion of AMP to ATP leads to the generation of distinct bioluminescence signal. The PNK activity assay can be performed in real time by continuously monitoring the bioluminescence signal. This bioluminescent sensor is much simpler, label-free, cost-effective, and free from the autofluorescence interference of biological matrix, and can be further used for quantitative, kinetic, and inhibition assay.

  3. Monitoring Biosensor Activity in Living Cells with Fluorescence Lifetime Imaging Microscopy

    PubMed Central

    Hum, Julia M.; Siegel, Amanda P.; Pavalko, Fredrick M.; Day, Richard N.

    2012-01-01

    Live-cell microscopy is now routinely used to monitor the activities of the genetically encoded biosensor proteins that are designed to directly measure specific cell signaling events inside cells, tissues, or organisms. Most fluorescent biosensor proteins rely on Förster resonance energy transfer (FRET) to report conformational changes in the protein that occur in response to signaling events, and this is commonly measured with intensity-based ratiometric imaging methods. An alternative method for monitoring the activities of the FRET-based biosensor proteins is fluorescence lifetime imaging microscopy (FLIM). FLIM measurements are made in the time domain, and are not affected by factors that commonly limit intensity measurements. In this review, we describe the use of the digital frequency domain (FD) FLIM method for the analysis of FRET signals. We illustrate the methods necessary for the calibration of the FD FLIM system, and demonstrate the analysis of data obtained from cells expressing “FRET standard” fusion proteins. We then use the FLIM-FRET approach to monitor the changes in activities of two different biosensor proteins in specific regions of single living cells. Importantly, the factors required for the accurate determination and reproducibility of lifetime measurements are described in detail. PMID:23203070

  4. Sensor Monitoring of Physical Activity to Improve Glucose Management in Diabetic Patients: A Review

    PubMed Central

    Ding, Sandrine; Schumacher, Michael

    2016-01-01

    Diabetic individuals need to tightly control their blood glucose concentration. Several methods have been developed for this purpose, such as the finger-prick or continuous glucose monitoring systems (CGMs). However, these methods present the disadvantage of being invasive. Moreover, CGMs have limited accuracy, notably to detect hypoglycemia. It is also known that physical exercise, and even daily activity, disrupt glucose dynamics and can generate problems with blood glucose regulation during and after exercise. In order to deal with these challenges, devices for monitoring patients’ physical activity are currently under development. This review focuses on non-invasive sensors using physiological parameters related to physical exercise that were used to improve glucose monitoring in type 1 diabetes (T1DM) patients. These devices are promising for diabetes management. Indeed they permit to estimate glucose concentration either based solely on physical activity parameters or in conjunction with CGM or non-invasive CGM (NI-CGM) systems. In these last cases, the vital signals are used to modulate glucose estimations provided by the CGM and NI-CGM devices. Finally, this review indicates possible limitations of these new biosensors and outlines directions for future technologic developments. PMID:27120602

  5. A daily living activity remote monitoring system for solitary elderly people.

    PubMed

    Maki, Hiromichi; Ogawa, Hidekuni; Matsuoka, Shingo; Yonezawa, Yoshiharu; Caldwell, W Morton

    2011-01-01

    A daily living activity remote monitoring system has been developed for supporting solitary elderly people. The monitoring system consists of a tri-axis accelerometer, six low-power active filters, a low-power 8-bit microcontroller (MC), a 1GB SD memory card (SDMC) and a 2.4 GHz low transmitting power mobile phone (PHS). The tri-axis accelerometer attached to the subject's chest can simultaneously measure dynamic and static acceleration forces produced by heart sound, respiration, posture and behavior. The heart rate, respiration rate, activity, posture and behavior are detected from the dynamic and static acceleration forces. These data are stored in the SD. The MC sends the data to the server computer every hour. The server computer stores the data and makes a graphic chart from the data. When the caregiver calls from his/her mobile phone to the server computer, the server computer sends the graphical chart via the PHS. The caregiver's mobile phone displays the chart to the monitor graphically.

  6. A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin

    PubMed Central

    Kommagani, Ramakrishna; Peavey, Mary C.; Hai, Lan; Lonard, David M.; Lydon, John P.

    2017-01-01

    This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder transgenic mouse contains the TetO-ΔN89β-CatTMILA transgene, which consists of the tet-operator followed by a bicistronic sequence encoding a stabilized form of active β-catenin (ΔN89β-catenin), an internal ribosome entry site, and the firefly luciferase gene. To confirm that the transgene operates as designed, TetO-ΔN89β-CatTMILA transgenic mouse lines were crossed with an effector mouse that harbors the mouse mammary tumor virus-reverse tetracycline transactivator (MMTV-rtTA) transgene (termed MTB hereon), which primarily targets rtTA expression to the mammary epithelium. Following doxycycline administration, the resultant MTB/CatTMILA bigenic reporter exhibited precocious lobuloalveologenesis, ductal hyperplasia, and mammary adenocarcinomas, which were visualized and monitored by in vivo bioluminescence detection. Therefore, we predict that the TetO-ΔN89β-CatTMILA transgenic responder mouse—when crossed with the appropriate effector transgenic—will have wide-applicability to non-invasively monitor the influence of constitutively active β-catenin expression on cell-fate specification, proliferation, differentiation, and neoplastic transformation in a broad spectrum of target tissues. PMID:28253313

  7. A language activity monitor for supporting AAC evidence-based clinical practice.

    PubMed

    Hill, K J; Romich, B A

    2001-01-01

    Augmentative and alternative communication (AAC) evidence-based practice requires the collection and analysis of performance data. This article presents the development, evaluation, and application of automated performance monitoring tools for use in clinical practice. Language activity monitoring (LAM) is the systematic data collection of the actual language activity of an individual who relies on AAC. Work completed to date includes the development and evaluation of the language activity monitor function, which now is commercially available in three forms: (1) a standard feature built into modern high performance AAC systems, (2) an external add-on package for use with older AAC devices based on synthetic speech, and (3) software that allows the personal computer to serve as an LAM in the clinical environment. The LAM records the time and content of language events (the generation of one or more letters or words). A logging protocol suitable for clinical application has been in use since late 1998. The logged data is uploaded periodically to a computer for editing, analysis, and the generation of a summary measure report. The applications of this work in the areas of clinical service delivery are presented.

  8. Assessment of laboratory and daily energy expenditure estimates from consumer multi-sensor physical activity monitors

    PubMed Central

    Chowdhury, Enhad A.; Western, Max J.; Nightingale, Thomas E.; Peacock, Oliver J.; Thompson, Dylan

    2017-01-01

    Wearable physical activity monitors are growing in popularity and provide the opportunity for large numbers of the public to self-monitor physical activity behaviours. The latest generation of these devices feature multiple sensors, ostensibly similar or even superior to advanced research instruments. However, little is known about the accuracy of their energy expenditure estimates. Here, we assessed their performance against criterion measurements in both controlled laboratory conditions (simulated activities of daily living and structured exercise) and over a 24 hour period in free-living conditions. Thirty men (n = 15) and women (n = 15) wore three multi-sensor consumer monitors (Microsoft Band, Apple Watch and Fitbit Charge HR), an accelerometry-only device as a comparison (Jawbone UP24) and validated research-grade multi-sensor devices (BodyMedia Core and individually calibrated Actiheart™). During discrete laboratory activities when compared against indirect calorimetry, the Apple Watch performed similarly to criterion measures. The Fitbit Charge HR was less consistent at measurement of discrete activities, but produced similar free-living estimates to the Apple Watch. Both these devices underestimated free-living energy expenditure (-394 kcal/d and -405 kcal/d, respectively; P<0.01). The multi-sensor Microsoft Band and accelerometry-only Jawbone UP24 devices underestimated most laboratory activities and substantially underestimated free-living expenditure (-1128 kcal/d and -998 kcal/d, respectively; P<0.01). None of the consumer devices were deemed equivalent to the reference method for daily energy expenditure. For all devices, there was a tendency for negative bias with greater daily energy expenditure. No consumer monitors performed as well as the research-grade devices although in some (but not all) cases, estimates were close to criterion measurements. Thus, whilst industry-led innovation has improved the accuracy of consumer monitors, these devices

  9. Assessment of laboratory and daily energy expenditure estimates from consumer multi-sensor physical activity monitors.

    PubMed

    Chowdhury, Enhad A; Western, Max J; Nightingale, Thomas E; Peacock, Oliver J; Thompson, Dylan

    2017-01-01

    Wearable physical activity monitors are growing in popularity and provide the opportunity for large numbers of the public to self-monitor physical activity behaviours. The latest generation of these devices feature multiple sensors, ostensibly similar or even superior to advanced research instruments. However, little is known about the accuracy of their energy expenditure estimates. Here, we assessed their performance against criterion measurements in both controlled laboratory conditions (simulated activities of daily living and structured exercise) and over a 24 hour period in free-living conditions. Thirty men (n = 15) and women (n = 15) wore three multi-sensor consumer monitors (Microsoft Band, Apple Watch and Fitbit Charge HR), an accelerometry-only device as a comparison (Jawbone UP24) and validated research-grade multi-sensor devices (BodyMedia Core and individually calibrated Actiheart™). During discrete laboratory activities when compared against indirect calorimetry, the Apple Watch performed similarly to criterion measures. The Fitbit Charge HR was less consistent at measurement of discrete activities, but produced similar free-living estimates to the Apple Watch. Both these devices underestimated free-living energy expenditure (-394 kcal/d and -405 kcal/d, respectively; P<0.01). The multi-sensor Microsoft Band and accelerometry-only Jawbone UP24 devices underestimated most laboratory activities and substantially underestimated free-living expenditure (-1128 kcal/d and -998 kcal/d, respectively; P<0.01). None of the consumer devices were deemed equivalent to the reference method for daily energy expenditure. For all devices, there was a tendency for negative bias with greater daily energy expenditure. No consumer monitors performed as well as the research-grade devices although in some (but not all) cases, estimates were close to criterion measurements. Thus, whilst industry-led innovation has improved the accuracy of consumer monitors, these devices

  10. Smart interactive electronic system for monitoring the electromagnetic activities of biological systems

    NASA Astrophysics Data System (ADS)

    Popa, Sorin G.; Shahinpoor, Mohsen

    2001-08-01

    A novel electronic device capable of sensing and monitoring the myoelectric, polarization wave and electromagnetic activities of the biological systems and in particular the human body is presented. It is known that all the physical and chemical processes within biological systems are associated with polarization, depolarization waves from the brain, neural signals and myoelectric processes that manifest themselves in ionic and dipole motion. The technology developed in our laboratory is based on certain charge motion sensitive electronics. The electronic system developed is capable of sensing the electromagnetic activities of biological systems. The information obtained is then processed by specialized software in order to interpret it from physical and chemical point of view.

  11. Adolescents' leisure activities, parental monitoring and cigarette smoking - a cross-sectional study

    PubMed Central

    2011-01-01

    Background Adolescent participation in leisure activities is developmentally beneficial, but certain activities may increase health compromising behaviours, such as tobacco smoking. A limited range of leisure activities has been studied, with little research on out-of-school settings where parental supervision is a potential protective factor. Tobacco smoking is an important, potentially modifiable health determinant, so understanding associations between adolescent leisure activities, parental monitoring, demographic factors and daily smoking may inform preventive strategies. These associations are reported for a New Zealand adolescent sample. Methods Randomly selected schools (n = 145) participated in the 2006 Youth In-depth Survey, a national, biennial study of Year 10 students (predominantly 14-15 years). School classes were randomly selected and students completed a self-report questionnaire in class time. Adjustment for clustering at the school level was included in all analyses. Since parental monitoring and demographic variables potentially confound relations between adolescent leisure activities and smoking, variables were screened before multivariable modelling. Given prior indications of demographic differences, gender and ethnic specific regression models were built. Results and Discussion Overall, 8.5% of the 3,161 students were daily smokers, including more females (10.5%) than males (6.5%). In gender and ethnic specific multivariate analysis of associations with daily smoking (adjusted for age, school socioeconomic decile rating, leisure activities and ethnicity or gender, respectively), parental monitoring exhibited a consistently protective, dose response effect, although less strongly among Māori. Attending a place of worship and going to the movies were protective for non-Māori, as was watching sports, whereas playing team sport was protective for all, except males. Attending a skate park was a risk factor for females and Māori which

  12. Psychological adaptation of liver transplant recipients.

    PubMed

    Pérez-San-Gregorio, M A; Martin-Rodríguez, A; Asián-Chavez, E; Gallego-Corpa, A; Pérez-Bernal, J

    2005-04-01

    We analyzed the influence of two variables (place of hospitalization of the patients and the mental health of relatives) on symptoms of anxiety and depression in liver transplant patients. The subject groups were made up of 48 liver transplant recipients (mean age 51.15; SD = 8.57) and their close relatives. The tests applied were a psychosocial questionnaire, and the two tests: "The Hospital Anxiety and Depression Scale" and "The Leeds Scales for the Self-Assessment of Anxiety and Depression." The liver transplant recipients showed more symptoms of depression when they were in the intensive care unit (ICU) and more symptoms of anxiety in the post-ICU phase when their close relatives were more depressed in that phase. The place of hospitalization of the patients and the mental health of relatives influenced the symptoms of anxiety and depression in liver transplant recipients.

  13. Inventory of non-federally funded marine pollution research, development and monitoring activities: Northeast and Mid-Atlantic Region

    SciTech Connect

    Caton, G.M.; Opresko, D.M.; Weaver, S.S.; Margulies, D.; Zacherle, A.W.

    1985-12-01

    This report includes descriptions of projects which were partially funded by the Federal Government, although the Federal contributions are not considered in the funding analyses. This report only considers marine pollution research, development, and monitoring activities. ''Research'' projects include studies, investigations, and surveys to study the sources, behavior, and effects of pollutants and polluting activities as well as studies concerning natural oceanic processes if these studies are conducted to improve understanding concerning pollutants and polluting activities. ''Development'' projects include efforts to provide analytical methods, instrumentation, and equipment necessary for research and monitoring of marine pollution. ''Monitoring'' projects include time-series observations of marine environmental conditions to determine the existing levels, trends in time and space, and natural variations in parameters measured. Some projects fall into the category of ''compliance'' monitoring. ''Compliance'' monitoring is generally undertaken for a permitted or licensed resource development activity to assure that an unacceptable level of environmental change has not occurred.

  14. Erythrocyte C3d and C4d for Monitoring Disease Activity in Systemic Lupus Erythematosus

    PubMed Central

    Kao, Amy H.; Navratil, Jeannine S.; Ruffing, Margie J.; Liu, Chau-Ching; Hawkins, Douglas; McKinnon, Kathleen M.; Danchenko, Natalya; Ahearn, Joseph M.; Manzi, Susan

    2010-01-01

    Objective Disease activity in systemic lupus erythematosus (SLE) is typically monitored by measuring serum C3 and C4. However, these proteins have limited utility as lupus biomarkers, because they are substrates rather than products of complement activation. The aim of this study was to evaluate the utility of measuring the erythrocyte-bound complement activation products, erythrocyte-bound C3d (E-C3d) and E-C4d, compared with that of serum C3 and C4 for monitoring disease activity in patients with SLE. Methods The levels of E-C3d and E-C4d were measured by flow cytometry in 157 patients with SLE, 290 patients with other diseases, and 256 healthy individuals. The patients with SLE were followed up longitudinally. Disease activity was measured at each visit, using the validated Systemic Lupus Activity Measure (SLAM) and the Safety of Estrogens in Lupus Erythematosus: National Assessment (SELENA) version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results At baseline, patients with SLE had higher median levels of E-C3d and E-C4d (P < 0.0001) in addition to higher within-patient and between-patient variability in both E-C3d and E-C4d when compared with the 2 non-SLE groups. In a longitudinal analysis of patients with SLE, E-C3d, E-C4d, serum C3, and anti–double-stranded DNA (anti-dsDNA) antibodies were each significantly associated with the SLAM and SELENA–SLEDAI. In a multivariable analysis, E-C4d remained significantly associated with these SLE activity measures after adjusting for serum C3, C4, and anti-dsDNA antibodies; however, E-C3d was associated with the SLAM but not with the SELENA–SLEDAI. Conclusion Determining the levels of the erythrocyte-bound complement activation products, especially E-C4d, is an informative measure of SLE disease activity as compared with assessing serum C4 levels and should be considered for monitoring disease activity in patients with SLE. PMID:20187154

  15. Anti-asialo GM1 antiserum treatment of lethally irradiated recipients before bone marrow transplantation: Evidence that recipient natural killer depletion enhances survival, engraftment, and hematopoietic recovery

    SciTech Connect

    Tiberghien, P.; Longo, D.L.; Wine, J.W.; Alvord, W.G.; Reynolds, C.W. )

    1990-10-01

    Natural killer (NK) cells are reported to have an important role in the resistance of lethally irradiated recipients to bone marrow transplantation (BMT). Therefore, we investigated the effects of recipient NK depletion on survival, chimerism, and hematopoietic reconstitution after lethal irradiation and the transplantation of limiting amounts of T-cell-deficient bone marrow (BM). When administered before BMT, anti-asialo GM1 (ASGM1) antiserum treatment, effective in depleting in vivo NK activity, was associated with a marked increase in survival in 3 of 3 allogeneic combinations (BALB/c into C3H/HeN, C57B1/6, or C3B6F1). This enhanced survival was independent of the susceptibility of each recipient strain to accept BALB/c BM. Moreover, recipient anti-ASGM1 treatment was also effective in increasing survival in recipients of syngeneic BM, suggesting that NK cells can adversely affect engraftment independent of genetically controlled polymorphic cell surface determinants. Analysis of chimerism in surviving animals 2 months post-BMT showed that recipient NK depletion significantly increased the level of donor engraftment when high doses of BM were transplanted. These studies also demonstrated that anti-ASGM1 pretreatment mainly resulted in an increase in extramedullary hematopoiesis in the second and third week after irradiation. Anti-ASGM1 treatment also dramatically accelerated the rate of appearance of donor-derived cells with a higher level of donor-cell engraftment apparent at a time when the differences in survival between NK-depleted and control BMT recipients became significant. Peripheral cell counts were also affected by NK depletion, with significantly enhanced platelet and red blood cell recovery and a moderate increase in granulocyte recovery.

  16. An MFC-based online monitoring and alert system for activated sludge process.

    PubMed

    Xu, Gui-Hua; Wang, Yun-Kun; Sheng, Guo-Ping; Mu, Yang; Yu, Han-Qing

    2014-10-27

    In this study, based on a simple, compact and submersible microbial fuel cell (MFC), a novel online monitoring and alert system with self-diagnosis function was established for the activated sludge (AS) process. Such a submersible MFC utilized organic substrates and oxygen in the AS reactor as the electron donor and acceptor respectively, and could provide an evaluation on the status of the AS reactor and thus give a reliable early warning of potential risks. In order to evaluate the reliability and sensitivity of this online monitoring and alert system, a series of tests were conducted to examine the response of this system to various shocks imposed on the AS reactor. The results indicate that this online monitoring and alert system was highly sensitive to the performance variations of the AS reactor. The stability, sensitivity and repeatability of this online system provide feasibility of being incorporated into current control systems of wastewater treatment plants to real-time monitor, diagnose, alert and control the AS process.

  17. Scour monitoring system for subsea pipeline based on active thermometry: numerical and experimental studies.

    PubMed

    Zhao, Xuefeng; Li, Weijie; Song, Gangbing; Zhu, Zuo; Du, Jun

    2013-01-24

    A scour monitoring system for subsea pipeline based on active thermometry is proposed in this paper. The temperature reading of the proposed system is based on a distributed Brillouin optical fiber sensing technique. A thermal cable acts as the main component of the system, which consists of a heating belt, armored optical fibers and heat-shrinkable tubes which run parallel to the pipeline. The scour-induced free span can be monitored through different heat transfer behaviors of in-water and in-sediment scenarios during heating and cooling processes. Two sets of experiments, including exposing different lengths of the upper surface of the pipeline to water and creating free spans of various lengths, were carried out in laboratory. In both cases, the scour condition was immediately detected by the proposed monitoring system, which confirmed the system is robust and very sensitive. Numerical study of the method was also investigated by using the finite element method (FEM) with ANSYS, resulting in reasonable agreement with the test data. This brand new system provides a promising, low cost, highly precise and flexible approach for scour monitoring of subsea pipelines.

  18. False Alarm Reduction in BSN-Based Cardiac Monitoring Using Signal Quality and Activity Type Information

    PubMed Central

    Tanantong, Tanatorn; Nantajeewarawat, Ekawit; Thiemjarus, Surapa

    2015-01-01

    False alarms in cardiac monitoring affect the quality of medical care, impacting on both patients and healthcare providers. In continuous cardiac monitoring using wireless Body Sensor Networks (BSNs), the quality of ECG signals can be deteriorated owing to several factors, e.g., noises, low battery power, and network transmission problems, often resulting in high false alarm rates. In addition, body movements occurring from activities of daily living (ADLs) can also create false alarms. This paper presents a two-phase framework for false arrhythmia alarm reduction in continuous cardiac monitoring, using signals from an ECG sensor and a 3D accelerometer. In the first phase, classification models constructed using machine learning algorithms are used for labeling input signals. ECG signals are labeled with heartbeat types and signal quality levels, while 3D acceleration signals are labeled with ADL types. In the second phase, a rule-based expert system is used for combining classification results in order to determine whether arrhythmia alarms should be accepted or suppressed. The proposed framework was validated on datasets acquired using BSNs and the MIT-BIH arrhythmia database. For the BSN dataset, acceleration and ECG signals were collected from 10 young and 10 elderly subjects while they were performing ADLs. The framework reduced the false alarm rate from 9.58% to 1.43% in our experimental study, showing that it can potentially assist physicians in diagnosing a vast amount of data acquired from wireless sensors and enhance the performance of continuous cardiac monitoring. PMID:25671512

  19. Design and Clinical Feasibility of Personal Wearable Monitor for Measurement of Activity and Environmental Exposure

    PubMed Central

    Ribón Fletcher, Richard; Oreskovic, Nicolas M.; Robinson, Alyssa I.

    2015-01-01

    Human exposure to specific environmental factors (e.g. air quality, lighting, and sound) is known to play an important role in the pathogenesis of many chronic diseases (e.g. asthma) and mental health disorders (e.g. anxiety). However, conventional fixed environmental monitoring stations are sparsely located and, despite environmental models, cannot adequately assess individual exposure levels. New forms of low-cost portable monitors have begun to emerge that enable the collection of higher spatial density “crowd sourced” data; however, the first generation of these low-cost environmental monitors have generally not been suitable for clinical environmental health studies due to practical challenges such as calibration, reproducibility, form factor, and battery life. In this paper, we present a wearable environmental monitor that overcomes these challenges and can be used in clinical studies The new device, called “Eco-Mini,” can be used without a smart phone and is capable of locally sampling and recording a variety of environmental parameters (Ozone, Sulfur Dioxide, Volatile Organic Compounds, humidity, temperature, ambient light color balance, and sound level) as well as individual activity (3-axis accelerometer) and location (GPS). In this paper, we also report findings and discuss lessons learned from a feasibility study conducted for one week with pediatric patients as part of an ongoing asthma research study. PMID:25570098

  20. Scour Monitoring System for Subsea Pipeline Based on Active Thermometry: Numerical and Experimental Studies

    PubMed Central

    Zhao, Xuefeng; Li, Weijie; Song, Gangbing; Zhu, Zuo; Du, Jun

    2013-01-01

    A scour monitoring system for subsea pipeline based on active thermometry is proposed in this paper. The temperature reading of the proposed system is based on a distributed Brillouin optical fiber sensing technique. A thermal cable acts as the main component of the system, which consists of a heating belt, armored optical fibers and heat-shrinkable tubes which run parallel to the pipeline. The scour-induced free span can be monitored through different heat transfer behaviors of in-water and in-sediment scenarios during heating and cooling processes. Two sets of experiments, including exposing different lengths of the upper surface of the pipeline to water and creating free spans of various lengths, were carried out in laboratory. In both cases, the scour condition was immediately detected by the proposed monitoring system, which confirmed the system is robust and very sensitive. Numerical study of the method was also investigated by using the finite element method (FEM) with ANSYS, resulting in reasonable agreement with the test data. This brand new system provides a promising, low cost, highly precise and flexible approach for scour monitoring of subsea pipelines. PMID:23348035

  1. Multi-Source Autonomous Response for Targeting and Monitoring of Volcanic Activity

    NASA Technical Reports Server (NTRS)

    Davies, Ashley G.; Doubleday, Joshua R.; Tran, Daniel Q.

    2014-01-01

    The study of volcanoes is important for both purely scientific and human survival reasons. From a scientific standpoint, volcanic gas and ash emissions contribute significantly to the terrestrial atmosphere. Ash depositions and lava flows can also greatly affect local environments. From a human survival standpoint, many people live within the reach of active volcanoes, and therefore can be endangered by both atmospheric (ash, debris) toxicity and lava flow. There are many potential information sources that can be used to determine how to best monitor volcanic activity worldwide. These are of varying temporal frequency, spatial regard, method of access, and reliability. The problem is how to incorporate all of these inputs in a general framework to assign/task/reconfigure assets to monitor events in a timely fashion. In situ sensing can provide a valuable range of complementary information such as seismographic, discharge, acoustic, and other data. However, many volcanoes are not instrumented with in situ sensors, and those that have sensor networks are restricted to a relatively small numbers of point sensors. Consequently, ideal volcanic study synergistically combines space and in situ measurements. This work demonstrates an effort to integrate spaceborne sensing from MODIS (Terra and Aqua), ALI (EO-1), Worldview-2, and in situ sensing in an automated scheme to improve global volcano monitoring. Specifically, it is a "sensor web" concept in which a number of volcano monitoring systems are linked together to monitor volcanic activity more accurately, and this activity measurement automatically tasks space assets to acquire further satellite imagery of ongoing volcanic activity. A general framework was developed for evidence combination that accounts for multiple information sources in a scientist-directed fashion to weigh inputs and allocate observations based on the confidence of an events occurrence, rarity of the event at that location, and other scientists

  2. International Collaboration on Building Local Technical Capacities for Monitoring Volcanic Activity at Pacaya Volcano, Guatemala.

    NASA Astrophysics Data System (ADS)

    Escobar-Wolf, R. P.; Chigna, G.; Morales, H.; Waite, G. P.; Oommen, T.; Lechner, H. N.

    2015-12-01

    Pacaya volcano is a frequently active and potentially dangerous volcano situated in the Guatemalan volcanic arc. It is also a National Park and a major touristic attraction, constituting an important economic resource for local municipality and the nearby communities. Recent eruptions have caused fatalities and extensive damage to nearby communities, highlighting the need for risk management and loss reduction from the volcanic activity. Volcanic monitoring at Pacaya is done by the Instituto Nacional de Sismologia, Vulcanologia, Meteorologia e Hidrologia (INSIVUMEH), instrumentally through one short period seismic station, and visually by the Parque Nacional Volcan de Pacaya y Laguna de Calderas (PNVPLC) personnel. We carry out a project to increase the local technical capacities for monitoring volcanic activity at Pacaya. Funding for the project comes from the Society of Exploration Geophysicists through the Geoscientists Without Borders program. Three seismic and continuous GPS stations will be installed at locations within 5 km from the main vent at Pacaya, and one webcam will aid in the visual monitoring tasks. Local educational and outreach components of the project include technical workshops on data monitoring use, and short thesis projects with the San Carlos University in Guatemala. A small permanent exhibit at the PNVPLC museum or visitor center, focusing on the volcano's history, hazards and resources, will also be established as part of the project. The strategy to involve a diverse group of local collaborators in Guatemala aims to increase the chances for long term sustainability of the project, and relies not only on transferring technology but also the "know-how" to make that technology useful. Although not a primary research project, it builds on a relationship of years of joint research projects at Pacaya between the participants, and could be a model of how to increase the broader impacts of such long term collaboration partnerships.

  3. Durable coexistence of donor and recipient strains after fecal microbiota transplantation.

    PubMed

    Li, Simone S; Zhu, Ana; Benes, Vladimir; Costea, Paul I; Hercog, Rajna; Hildebrand, Falk; Huerta-Cepas, Jaime; Nieuwdorp, Max; Salojärvi, Jarkko; Voigt, Anita Y; Zeller, Georg; Sunagawa, Shinichi; de Vos, Willem M; Bork, Peer

    2016-04-29

    Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.

  4. Isolated cerebral post-transplant lymphoproliferative disorder in a lymphoma recipient.

    PubMed

    Tang, Tzung-Chih; Chuang, Wen-Yu; Chang, Hung

    2013-01-01

    Post-transplant lymphoproliferative disorder (PTLD) can occur after solid organ transplantation (SOT) or hematopoietic stem cell transplantation (HSCT). The majority of PTLDs are related to the reactivation of Epstein-Barr virus (EBV) in the lymphoid organs. PLTDs in HSCT recipients tend to present with systemic involvement, and isolated PTLD in these patients is rare. Only 14 isolated cerebral PTLDs have been reported in HSCT recipients, and none have been reported in lymphoma patients. When diagnosing PTLD in a lymphoma patient, it is challenging to discriminate between a PTLD that originated from previous disease and a newly developed clone and to distinguish between donor and recipient origin. In this report, we present the first case of a B-cell lymphoma patient who developed isolated PTLD in the CNS, and we confirmed that the PTLD originated in a distinct clone and from a different origin. Furthermore, the role of EBV-DNA monitoring in such patients is discussed.

  5. Clostridium difficile infection, a descriptive analysis of solid organ transplant recipients at a single center.

    PubMed

    Tsapepas, Demetra S; Martin, Spencer T; Miao, Jennifer; Shah, Shreya A; Scheffert, Jenna; Fester, Keith; Ma, Karlene; Lat, Asma; Egan, Ron; McKeen, Jaclyn T

    2015-04-01

    Clostridium difficile is a bacterial enteric pathogen, which causes clinical disease among solid organ transplant (SOT) recipients. This large, single-center, retrospective study describes incidence, demographics, and impact of C. difficile infection (CDI) among adult SOT recipients, cardiac (n=5), lung (n=14), liver (n=9), renal (n=26), and multiorgan (n=9) patients transplanted and diagnosed with CDI (geneB PCR) between 9/2009 and 12/2012. The overall incidence of CDI in our population during the 40-month period of study was 4%. CDI incidence among cardiac, lung, liver, and renal transplant recipients was 1.9%, 7%, 2.7%, and 3.2%, respectively (P=0.03 between organ-types). Median time from transplant to CDI for all was 51 (14-249) days, with liver recipients having the shortest time to infection, median 36 (15-101) days, and lung recipients having a longer time to infection, median 136 (29-611) days. Antibiotic exposure within 3 months of CDI was evident in 45 of the 63 (71%) patients in this study, 80%, 79%, 100%, 58%, and 67% of cardiac, lung, liver, renal, and multiorgan transplant recipients, respectively. Most patients (83%) were hospitalized within the 3 months preceding CDI. Recipients were followed for a median time of 23 (16-31) months; at the time of last follow-up, 83% of allografts were functioning, and 86% of patients were alive. One death and 1 graft failure were causally related to CDI. CDI had an overall incidence of 4%; clinicians should have heightened awareness for CDI, especially among patients receiving antibiotics, with increased monitoring and aggressive management of CDI.

  6. Lung Transplant Recipient with Pulmonary Alveolar Proteinosis

    PubMed Central

    Hahn, M. Frances; Abdelrazek, Hesham; Patel, Vipul J.; Walia, Rajat

    2016-01-01

    Pulmonary alveolar proteinosis (PAP) is a progressive lung disease characterized by accumulated surfactant-like lipoproteinaceous material in the alveoli and distal bronchioles. This accumulation is the result of impaired clearance by alveolar macrophages. PAP has been described in 11 solid organ transplant recipients, 9 of whom were treated with mammalian target of rapamycin inhibitors. We report a case of a lung transplant recipient treated with prednisone, mycophenolate mofetil (MMF), and tacrolimus who ultimately developed PAP, which worsened when MMF was replaced with everolimus. PMID:27213073

  7. Validation of a microwave radar system for the monitoring of locomotor activity in mice

    PubMed Central

    Pasquali, Vittorio; Scannapieco, Eugenio; Renzi, Paolo

    2006-01-01

    Background The general or spontaneous motor activity of animals is a useful parameter in chronobiology. Modified motion detectors can be used to monitor locomotor activity rhythms. We modified a commercial microwave-based detection device and validated the device by recording circadian and ultradian rhythms. Methods Movements were detected by microwave radar based on the Doppler effect. The equipment was designed to detect and record simultaneously 12 animals in separate cages. Radars were positioned at the bottom of aluminium bulkheads. Animal cages were positioned above the bulkheads. The radars were connected to a computer through a digital I/O board. Results The apparatus was evaluated by several tests. The first test showed the ability of the apparatus to detect the exact frequency of the standard moving object. The second test demonstrated the stability over time of the sensitivity of the radars. The third was performed by simultaneous observations of video-recording of a mouse and radar signals. We found that the radars are particularly sensitive to activities that involve a displacement of the whole body, as compared to movement of only a part of the body. In the fourth test, we recorded the locomotor activity of Balb/c mice. The results were in agreement with published studies. Conclusion Radar detectors can provide automatic monitoring of an animal's locomotor activity in its home cage without perturbing the pattern of its normal behaviour or initiating the spurt of exploration occasioned by transfer to a novel environment. Recording inside breeding cages enables long-term studies with uninterrupted monitoring. The use of electromagnetic waves allows contactless detection and freedom from interference of external stimuli. PMID:16674816

  8. Pre-transplant assessment of CMV-specific immune response by Elispot assay in kidney transplant recipients.

    PubMed

    Rittà, Massimo; Costa, Cristina; Sidoti, Francesca; Ballocco, Cinzia; Ranghino, Andrea; Messina, Maria; Biancone, Luigi; Cavallo, Rossana

    2015-07-01

    Cytomegalovirus (CMV) primary infection or re-activation in solid organ transplant (SOT) recipients is associated with increased morbidity and mortality, with patients with IgG-CMV D+/R- sero-matching at greater risk. The impact of pre-transplant CMV-specific host cellular immunity on the long-term risk of CMV replication in kidney transplants (KT) was prospectively evaluated in eighty patients by CMV-EliSpot assay. The study population included 54 male and 26 female recipients, with CMV-IgG distribution: 60 D+/R+, 11 D-/R+, 7 D+/R-, 2 D-/R-. At pre-transplantation, 49 KT (61.3%) were CMV-responders by EliSpot. At 3-month follow up, 16 (32.7%) out of 49 CMV-responders showed CMV blood infection, compared to 8 (25.8%) out of 31 non-responders. No further episode of CMV viraemia was reported in the responder group, in comparison to 15 out 31 non-responders (48.4%) showing at least one episode of CMV-DNAemia at 12-month follow-up. Baseline CMV-IgG serology showed a strong correlation with EliSpot determinations; KT recipients exhibiting at least one episode of CMV viraemia at 12-month follow-up showed lower baseline CMV-EliSpot values than those without signs of CMV replication. The study suggests that monitoring CMV-specific T-cell responses at pre-transplantation by EliSpot assay may be useful for predicting the post-transplantation risk of CMV infection and reactivation.

  9. Smartphone-Based Patients' Activity Recognition by Using a Self-Learning Scheme for Medical Monitoring.

    PubMed

    Guo, Junqi; Zhou, Xi; Sun, Yunchuan; Ping, Gong; Zhao, Guoxing; Li, Zhuorong

    2016-06-01

    Smartphone based activity recognition has recently received remarkable attention in various applications of mobile health such as safety monitoring, fitness tracking, and disease prediction. To achieve more accurate and simplified medical monitoring, this paper proposes a self-learning scheme for patients' activity recognition, in which a patient only needs to carry an ordinary smartphone that contains common motion sensors. After the real-time data collection though this smartphone, we preprocess the data using coordinate system transformation to eliminate phone orientation influence. A set of robust and effective features are then extracted from the preprocessed data. Because a patient may inevitably perform various unpredictable activities that have no apriori knowledge in the training dataset, we propose a self-learning activity recognition scheme. The scheme determines whether there are apriori training samples and labeled categories in training pools that well match with unpredictable activity data. If not, it automatically assembles these unpredictable samples into different clusters and gives them new category labels. These clustered samples combined with the acquired new category labels are then merged into the training dataset to reinforce recognition ability of the self-learning model. In experiments, we evaluate our scheme using the data collected from two postoperative patient volunteers, including six labeled daily activities as the initial apriori categories in the training pool. Experimental results demonstrate that the proposed self-learning scheme for activity recognition works very well for most cases. When there exist several types of unseen activities without any apriori information, the accuracy reaches above 80 % after the self-learning process converges.

  10. Monitoring and descriptive analysis of radon in relation to seismic activity of Northern Pakistan.

    PubMed

    Jilani, Zeeshan; Mehmood, Tahir; Alam, Aftab; Awais, Muhammad; Iqbal, Talat

    2017-03-16

    Earthquakes are one of the major causes of natural disasters and its forecasting is challenging task. Some precursory phenomenon exists in theory in relation to earthquakes occurrence. The emission of radioactive gas named 'radon' before the earthquakes is a potential earthquake precursory candidate. The study aims to monitor and to analyze the radon in relation to seismic activity in Northern Pakistan. For this purpose RTM-2200 has been used to monitor the changes in radon concentration from August 01, 2014 to January 31, 2015 in Northern Pakistan. Significant temporal variations has been observed in radon concentration. The bivariate analysis of radon with other variables manifests its positive relationship with air pressure and relative humidity and negative relationship with temperature. 2σ upper control limit on monthly basis are computed for detection of anomalous trends in the data. Overall increasing trend is detected in radon concentration. Five earthquakes from August 01, 2014 to January 31, 2015 have been selected from earthquake catalogue, depending upon their magnitude and distance from monitoring station and out of which radon concentration can be associated with only two earthquakes correlated with tectonic effect of radon concentration. Both of events have same magnitude 5.5 and occurred on September 13 and October 14, 2014 respectively. Very large variations have been observed in radon for the last two months of the study period, which may be occurred due to some other geological and environmental changes, but are not related to the earthquake activity.

  11. Standardized phenology monitoring methods to track plant and animal activity for science and resource management applications

    USGS Publications Warehouse

    Denny, Ellen G.; Gerst, Katharine L.; Miller-Rushing, Abraham J.; Tierney, Geraldine L.; Crimmins, Theresa M.; Enquist, Carolyn A.F.; Guertin, Patricia; Rosemartin, Alyssa H.; Schwartz, Mark D.; Thomas, Kathryn A.; Weltzin, Jake F.

    2014-01-01

    Phenology offers critical insights into the responses of species to climate change; shifts in species’ phenologies can result in disruptions to the ecosystem processes and services upon which human livelihood depends. To better detect such shifts, scientists need long-term phenological records covering many taxa and across a broad geographic distribution. To date, phenological observation efforts across the USA have been geographically limited and have used different methods, making comparisons across sites and species difficult. To facilitate coordinated cross-site, cross-species, and geographically extensive phenological monitoring across the nation, the USA National Phenology Network has developed in situ monitoring protocols standardized across taxonomic groups and ecosystem types for terrestrial, freshwater, and marine plant and animal taxa. The protocols include elements that allow enhanced detection and description of phenological responses, including assessment of phenological “status”, or the ability to track presence–absence of a particular phenophase, as well as standards for documenting the degree to which phenological activity is expressed in terms of intensity or abundance. Data collected by this method can be integrated with historical phenology data sets, enabling the development of databases for spatial and temporal assessment of changes in status and trends of disparate organisms. To build a common, spatially, and temporally extensive multi-taxa phenological data set available for a variety of research and science applications, we encourage scientists, resources managers, and others conducting ecological monitoring or research to consider utilization of these standardized protocols for tracking the seasonal activity of plants and animals.

  12. Standardized phenology monitoring methods to track plant and animal activity for science and resource management applications

    NASA Astrophysics Data System (ADS)

    Denny, Ellen G.; Gerst, Katharine L.; Miller-Rushing, Abraham J.; Tierney, Geraldine L.; Crimmins, Theresa M.; Enquist, Carolyn A. F.; Guertin, Patricia; Rosemartin, Alyssa H.; Schwartz, Mark D.; Thomas, Kathryn A.; Weltzin, Jake F.

    2014-05-01

    Phenology offers critical insights into the responses of species to climate change; shifts in species' phenologies can result in disruptions to the ecosystem processes and services upon which human livelihood depends. To better detect such shifts, scientists need long-term phenological records covering many taxa and across a broad geographic distribution. To date, phenological observation efforts across the USA have been geographically limited and have used different methods, making comparisons across sites and species difficult. To facilitate coordinated cross-site, cross-species, and geographically extensive phenological monitoring across the nation, the USA National Phenology Network has developed in situ monitoring protocols standardized across taxonomic groups and ecosystem types for terrestrial, freshwater, and marine plant and animal taxa. The protocols include elements that allow enhanced detection and description of phenological responses, including assessment of phenological "status", or the ability to track presence-absence of a particular phenophase, as well as standards for documenting the degree to which phenological activity is expressed in terms of intensity or abundance. Data collected by this method can be integrated with historical phenology data sets, enabling the development of databases for spatial and temporal assessment of changes in status and trends of disparate organisms. To build a common, spatially, and temporally extensive multi-taxa phenological data set available for a variety of research and science applications, we encourage scientists, resources managers, and others conducting ecological monitoring or research to consider utilization of these standardized protocols for tracking the seasonal activity of plants and animals.

  13. Children with High Functioning Autism show increased prefrontal and temporal cortex activity during error monitoring

    PubMed Central

    Goldberg, Melissa C.; Spinelli, Simona; Joel, Suresh; Pekar, James J.; Denckla, Martha B.; Mostofsky, Stewart H.

    2010-01-01

    Evidence exists for deficits in error monitoring in autism. These deficits may be particularly important because they may contribute to excessive perseveration and repetitive behavior in autism. We examined the neural correlates of error monitoring using fMRI in 8–12-year-old children with high-functioning autism (HFA, n=11) and typically developing children (TD, n=15) during performance of a Go/No-Go task by comparing the neural correlates of commission errors versus correct response inhibition trials. Compared to TD children, children with HFA showed increased BOLD fMRI signal in the anterior medial prefrontal cortex (amPFC) and the left superior temporal gyrus (STempG) during commission error (versus correct inhibition) trials. A follow-up region-of-interest analysis also showed increased BOLD signal in the right insula in HFA compared to TD controls. Our findings of increased amPFC and STempG activity in HFA, together with the increased activity in the insula, suggest a greater attention towards the internally-driven emotional state associated with making an error in children with HFA. Since error monitoring occurs across different cognitive tasks throughout daily life, an increased emotional reaction to errors may have important consequences for early learning processes. PMID:21151713

  14. Context-dependent olfactory learning monitored by activities of salivary neurons in cockroaches.

    PubMed

    Matsumoto, Chihiro Sato; Matsumoto, Yukihisa; Watanabe, Hidehiro; Nishino, Hiroshi; Mizunami, Makoto

    2012-01-01

    Context-dependent discrimination learning, a sophisticated form of nonelemental associative learning, has been found in many animals, including insects. The major purpose of this research is to establish a method for monitoring this form of nonelemental learning in rigidly restrained insects for investigation of underlying neural mechanisms. We report context-dependent olfactory learning (occasion-setting problem solving) of salivation, which can be monitored as activity changes of salivary neurons in immobilized cockroaches, Periplaneta americana. A group of cockroaches was trained to associate peppermint odor (conditioned stimulus, CS) with sucrose solution reward (unconditioned stimulus, US) while vanilla odor was presented alone without pairing with the US under a flickering light condition (1.0 Hz) and also trained to associate vanilla odor with sucrose reward while peppermint odor was presented alone under a steady light condition. After training, the responses of salivary neurons to the rewarded peppermint odor were significantly greater than those to the unrewarded vanilla odor under steady illumination and those to the rewarded vanilla odor was significantly greater than those to the unrewarded peppermint odor in the presence of flickering light. Similar context-dependent responses were observed in another group of cockroaches trained with the opposite stimulus arrangement. This study demonstrates context-dependent olfactory learning of salivation for the first time in any vertebrate and invertebrate species, which can be monitored by activity changes of salivary neurons in restrained cockroaches.

  15. An observational study of health literacy and medication adherence in adult kidney transplant recipients

    PubMed Central

    Demian, Maryam N.; Shapiro, R. Jean

    2016-01-01

    Background There is a high prevalence of non-adherence to immunosuppressants in kidney transplant recipients. Although limited health literacy is common in kidney recipients and is linked to adverse outcomes in other medical populations, its effect on medication adherence in kidney transplant recipients remains poorly understood. The objective was to investigate the effect of lower health literacy on immunosuppressant adherence. Methods Kidney recipients who were at least 6 months post-transplant and outpatients of Vancouver General Hospital in B.C., Canada were recruited through invitation letters. A total of 96 recipients completed the Health Literacy Questionnaire, which provides a multifactorial profile of self-reported health literacy and the Transplant Effects Questionnaire-Adherence subscale measuring self-reported immunosuppressant adherence. Hierarchical linear regression was used to analyze the association between health literacy and adherence after controlling for identified risk factors of non-adherence. Results Our sample was on average 53 years old, 56% male and 9 years post-transplant. Kidney recipients reported low levels of health literacy on scales measuring active health management and critical appraisal of information and 75% reported non-perfect adherence. Worse adherence was associated with poorer overall health literacy (ΔR2 = 0.08, P = 0.004) and lower scores on six of nine of the health literacy factors. Conclusions Poorer health literacy is associated with lower immunosuppressant adherence in adult kidney transplant recipients suggesting the importance of considering a recipient's level of health literacy in research and clinical contexts. Medication adherence interventions can target the six factors of health literacy identified as being risk factors for lower medication adherence. PMID:27994867

  16. Respiratory Failure due to Possible Donor-Derived Sporothrix schenckii Infection in a Lung Transplant Recipient

    PubMed Central

    Bahr, Nathan C.; Janssen, Katherine; Billings, Joanne; Loor, Gabriel; Green, Jaime S.

    2015-01-01

    Background. De novo and donor-derived invasive fungal infections (IFIs) contribute to morbidity and mortality in solid organ transplant (SOT) recipients. Reporting of donor-derived IFIs (DDIFIs) to the Organ Procurement Transplant Network has been mandated since 2005. Prior to that time no systematic monitoring of DDIFIs occurred in the United States. Case Presentation. We report a case of primary graft dysfunction in a 49-year-old male lung transplant recipient with diffuse patchy bilateral infiltrates likely related to pulmonary Sporothrix schenckii infection. The organism was isolated from a bronchoalveolar lavage on the second day after transplantation. Clinical and radiographic responses occurred after initiation of amphotericin B lipid formulation. Conclusion. We believe that this was likely a donor-derived infection given the early timing of the Sporothrix isolation after transplant in a bilateral single lung transplant recipient. This is the first case report of sporotrichosis in a lung transplant recipient. Our patient responded well to amphotericin induction therapy followed by maintenance therapy with itraconazole. The implications of donor-derived fungal infections and Sporothrix in transplant recipients are reviewed. Early recognition and management of these fungi are essential in improving outcomes. PMID:26697244

  17. Analyzing free-living physical activity of older adults in different environments using body-worn activity monitors.

    PubMed

    Grant, P Margaret; Granat, Malcolm H; Thow, Morag K; Maclaren, William M

    2010-04-01

    This study measured objectively the postural physical activity of 4 groups of older adults (> or =65 yr). The participants (N = 70) comprised 3 patient groups--2 from rehabilitation wards (city n = 20, 81.8 +/- 6.7 yr; rural n = 10, 79.4 +/- 4.7 yr) and the third from a city day hospital (n = 20, 74.7 +/- 7.9 yr)--and a healthy group to provide context (n = 20, 73.7 +/- 5.5 yr). The participants wore an activity monitor (activPAL) for a week. A restricted maximum-likelihood-estimation analysis of hourly upright time (standing and walking) revealed significant differences between day, hour, and location and the interaction between location and hour (p < .001). Differences in the manner in which groups accumulated upright and sedentary time (sitting and lying) were found, with the ward-based groups sedentary for prolonged periods and upright for short episodes. This information may be used by clinicians to design appropriate rehabilitation interventions and monitor patient progress.

  18. Field and Laboratory GPR Monitoring of Biological Activity in Saturated Porous Media

    NASA Astrophysics Data System (ADS)

    Tsoflias, Georgios; Schillig, Peter; McGlashan, Michael; Roberts, Jennifer; Devlin, J. F.

    2010-05-01

    Recent studies of the geophysical signatures of biological processes in earth environments have resulted in the emergent field of "biogeophysics". The ability to monitor remotely and to quantify active biological processes in the subsurface can have transformative implications to a wide range of investigations, including the bioremediation of contaminated sites. Previous studies have demonstrated that ground-penetrating radar (GPR) can be used to detect the products of microbial activity in the subsurface, such as changes in bulk electrical conductivity, mineral dissolution and precipitation, and the formation of biogenic gas. We present a field study and a laboratory experiment that offer insights to the response of GPR signals to microbial activity. In the field, time-lapse borehole radar tomography was used to monitor biodegradation of a hydrocarbon plume over a period of two years. A dense grid of fourteen borehole pairs monitoring the bioactive region showed radar wave velocity changes of +/-4% and signal attenuation changes of +/-25%. These GPR observations correlated spatially and temporally to independent measurements of groundwater velocity and geochemical variations that occurred in response to microbial activity. The greatest relative changes in radar wave velocity of propagation and attenuation were observed in the region of enhanced bacterial stimulation where biomass growth was the greatest. Radar wave velocity and attenuation decreased during periods of enhanced biostimulation. Three competing mechanisms are postulated to cause the changes observed in the radar data: 1) biogenic gas production, 2) mineral dissolution, and 3) biomass growth. However, due to the inherent complexity and uncertainties associated with field experimentation, the relative effect of each mechanism on the GPR signal could not be confirmed. To overcome the limitations of field observations in assessing the response of GPR signals to biomass formation, a 90-day laboratory

  19. Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin.

    PubMed

    Vandiver, Jeremy W; Vondracek, Thomas G

    2012-06-01

    Intravenous unfractionated heparin (UFH) remains an important therapeutic agent, particularly in the inpatient setting, for anticoagulation. Historically, the activated partial thromboplastin time (aPTT) has been the primary laboratory test used to monitor and adjust UFH. The aPTT test has evolved since the 1950s, and the historical goal range of 1.5-2.5 times the control aPTT, which first gained favor in the 1970s, has fallen out of favor due to a high degree of variability in aPTT readings from one laboratory to another, and even from one reagent to another. As a result, it is now recommended that the aPTT goal range be based on a corresponding heparin concentration of 0.2-0.4 unit/ml by protamine titration or 0.3-0.7 unit/ml by antifactor Xa assay. Given that several biologic factors can influence the aPTT independent of the effects of UFH, many institutions have transitioned to monitoring heparin with antifactor Xa levels, rather than the aPTT. Clinical data from the last 10-20 years have begun to show that a conversion from aPTT to antifactor Xa monitoring may offer a smoother dose-response curve, such that levels remain more stable, requiring fewer blood samples and dosage adjustments. Given the minimal increased acquisition cost of the antifactor Xa reagents, it can be argued that the antifactor Xa is a cost-effective method for monitoring UFH. In this review, we discuss the relative advantages and disadvantages of the aPTT, antifactor Xa, and protamine titration tests, and provide a clinical framework to guide practitioners who are seeking to optimize UFH monitoring within their own institutions.

  20. Use of cholinesterase activity in monitoring organophosphate pesticide exposure of cattle produced in tropical areas.

    PubMed

    Pardío, V T; Ibarra, N; Rodríguez, M A; Waliszewski, K N

    2001-12-01

    The use of cholinesterase activity as a biochemical method for monitoring organophosphate pesticide exposure in cattle is described herein. Determination of cholinesterase activity of whole blood, erythrocyte, and plasma was carried out according to the Ellman modified kinetic method. The mean baseline acetylcholinesterase activities of 9.549 +/- 3.619 IU/mL in whole blood, 9.444 +/- 3.006 IU/mL in erythrocytes, and 0.149 +/- 0.063 IU/mL in plasma were estimated for steers from the control group. Results of multivariate analysis showed that the general responses between the control and experimental groups (in vivo, monitoring and case studies) treated with Coumaphos and Fenthion were statistically different, and the general responses of these experimental groups were statistically different over time as well. Among the fractions that were analyzed, the erythrocyte acetylcholinesterase activity could be adequate for the diagnosis of exposure or acute poisoning in cattle as it showed a good within-run and between-run precision with CVs <10% better than those in plasma.

  1. A Combined sEMG and Accelerometer System for Monitoring Functional Activity in Stroke

    PubMed Central

    Roy, Serge H.; Cheng, M. Samuel; Chang, Shey-Sheen; Moore, John; De Luca, Gianluca; Nawab, S. Hamid; De Luca, Carlo J.

    2010-01-01

    Remote monitoring of physical activity using body-worn sensors provides an alternative to assessment of functional independence by subjective, paper-based questionnaires. This study investigated the classification accuracy of a combined surface electromyographic (sEMG) and accelerometer (ACC) sensor system for monitoring activities of daily living in patients with stroke. sEMG and ACC data (eight channels each) were recorded from 10 hemiparetic patients while they carried out a sequence of 11 activities of daily living (identification tasks), and 10 activities used to evaluate misclassification errors (nonidentification tasks). The sEMG and ACC sensor data were analyzed using a multilayered neural network and an adaptive neuro-fuzzy inference system to identify the minimal sensor configuration needed to accurately classify the identification tasks, with a minimal number of misclassifications from the nonidentification tasks. The results demonstrated that the highest sensitivity and specificity for the identification tasks was achieved using a subset of four ACC sensors and adjacent sEMG sensors located on both upper arms, one forearm, and one thigh, respectively. This configuration resulted in a mean sensitivity of 95.0%, and a mean specificity of 99.7% for the identification tasks, and a mean misclassification error of <10% for the nonidentification tasks. The findings support the feasibility of a hybrid sEMG and ACC wearable sensor system for automatic recognition of motor tasks used to assess functional independence in patients with stroke. PMID:20051332

  2. Preliminary study on activity monitoring using an android smart-watch.

    PubMed

    Ahanathapillai, Vijayalakshmi; Amor, James D; Goodwin, Zoe; James, Christopher J

    2015-02-01

    The global trend for increasing life expectancy is resulting in aging populations in a number of countries. This brings to bear a pressure to provide effective care for the older population with increasing constraints on available resources. Providing care for and maintaining the independence of an older person in their own home is one way that this problem can be addressed. The EU Funded Unobtrusive Smart Environments for Independent Living (USEFIL) project is an assistive technology tool being developed to enhance independent living. As part of USEFIL, a wrist wearable unit (WWU) is being developed to monitor the physical activity (PA) of the user and integrate with the USEFIL system. The WWU is a novel application of an existing technology to the assisted living problem domain. It combines existing technologies and new algorithms to extract PA parameters for activity monitoring. The parameters that are extracted include: activity level, step count and worn state. The WWU, the algorithms that have been developed and a preliminary validation are presented. The results show that activity level can be successfully extracted, that worn state can be correctly identified and that step counts in walking data can be estimated within 3% error, using the controlled dataset.

  3. Robot-assisted motor activation monitored by time-domain optical brain imaging

    NASA Astrophysics Data System (ADS)

    Steinkellner, O.; Wabnitz, H.; Schmid, S.; Steingräber, R.; Schmidt, H.; Krüger, J.; Macdonald, R.

    2011-07-01

    Robot-assisted motor rehabilitation proved to be an effective supplement to conventional hand-to-hand therapy in stroke patients. In order to analyze and understand motor learning and performance during rehabilitation it is desirable to develop a monitor to provide objective measures of the corresponding brain activity at the rehabilitation progress. We used a portable time-domain near-infrared reflectometer to monitor the hemodynamic brain response to distal upper extremity activities. Four healthy volunteers performed two different robot-assisted wrist/forearm movements, flexion-extension and pronation-supination in comparison with an unassisted squeeze ball exercise. A special headgear with four optical measurement positions to include parts of the pre- and postcentral gyrus provided a good overlap with the expected activation areas. Data analysis based on variance of time-of-flight distributions of photons through tissue was chosen to provide a suitable representation of intracerebral signals. In all subjects several of the four detection channels showed a response. In some cases indications were found of differences in localization of the activated areas for the various tasks.

  4. Autonomous thermal camera system for monitoring the active lava lake at Erebus volcano, Antarctica

    NASA Astrophysics Data System (ADS)

    Peters, N.; Oppenheimer, C.; Kyle, P.

    2014-02-01

    In December 2012, the Mount Erebus Volcano Observatory installed a thermal infrared camera system to monitor the volcano's active lava lake. The new system is designed to be autonomous, and capable of capturing images of the lava lake continuously throughout the year. This represents a significant improvement over previous systems which required the frequent attention of observatory researchers and could therefore only be operated during a few weeks of the annual field campaigns. The extreme environmental conditions at the summit of Erebus pose significant challenges for continuous monitoring equipment, and a custom-made system was the only viable solution. Here we describe the hardware and software of the new system in detail and report on a publicly available online repository where data will be archived. Aspects of the technical solutions we had to find in order to overcome the challenges of automating this equipment may be relevant in other environmental science domains where remote instrument operation is involved.

  5. Autonomous thermal camera system for monitoring the active lava lake at Erebus volcano, Antarctica

    NASA Astrophysics Data System (ADS)

    Peters, N.; Oppenheimer, C.; Kyle, P.

    2013-10-01

    In December 2012, the Mount Erebus Volcano Observatory installed a thermal infrared camera system to monitor the volcano's active lava lake. The new system is designed to be autonomous, and capable of capturing images of the lava lake continuously throughout the year. This represents a significant improvement over previous systems which required the frequent attention of observatory researchers and could therefore only be operated during a few weeks of the annual field campaigns. The extreme environmental conditions at the summit of Erebus pose significant challenges for continuous monitoring equipment, and a custom made system was the only viable solution. Here we describe the hardware and software of the new system in detail and report on a publicly-available online repository where data will be archived. Aspects of the technical solutions we had to find in order to overcome the challenges of automating this equipment may be relevant in other environmental science domains where remote instrument operation is involved.

  6. Mass spectrometric monitoring of interfacial photoelectron transfer and imaging of active crystalline facets of semiconductors

    NASA Astrophysics Data System (ADS)

    Zhong, Hongying; Zhang, Juan; Tang, Xuemei; Zhang, Wenyang; Jiang, Ruowei; Li, Rui; Chen, Disong; Wang, Peng; Yuan, Zhiwei

    2017-02-01

    Monitoring of interfacial electron transfer (ET) in situ is important to understand the ET mechanism and designing efficient photocatalysts. We describe herein a mass spectrometric approach to investigate the ultrafast transfer of photoelectrons that are generated by ultraviolet irradiation on surfaces of semiconductor nanoparticles or crystalline facets. The mass spectrometric approach can not only untargetedly detect various intermediates but also monitor their reactivity through associative or dissociative photoelectron capture dissociation, as well as electron detachment dissociation of adsorbed molecules. Proton-coupled electron transfer and proton-uncoupled electron transfer with radical initiated polymerization or hydroxyl radical abstraction have been unambiguously demonstrated with the mass spectrometric approach. Active crystalline facets of titanium dioxide for photocatalytic degradation of juglone and organochlorine dichlorodiphenyltrichloroethane are visualized with mass spectrometry imaging based on ion scanning and spectral reconstruction. This work provides a new technique for studying photo-electric properties of various materials.

  7. STS-55 MS1/PLC Ross monitors Payload Specialist Walter's Anthrorack activity

    NASA Technical Reports Server (NTRS)

    1993-01-01

    STS-55 German Payload Specialist 1 Ulrich Walter breathes into Rack 9 Anthrorack (AR) (Human Physiology Laboratory) device for Pulmonary Perfusion and Ventilation During Rest and Exercise experiment while working inside the Spacelab Deutsche 2 (SL-D2) science module aboard the Earth-orbiting Columbia, Orbiter Vehicle (OV) 102. Seated on the bicycle ergometer, Walter utilizes the respiratory monitoring system, part of a broad battery of experiments designed to investigate human physiology under microgravity conditions. In the background, Mission Specialist 1 (MS1) and Payload Commander (PLC) Jerry L. Ross monitors Walter's activity. Walter represents the German Aerospace Research Establishment (DLR) on the 10-day SL-D2 mission. Visible on the aft end cone are a fire extinguisher and the Crew Telesupport Experiment (CTE) Macintosh portable computer mounted on an adjustable work platform.

  8. Methods of InSAR atmosphere correction for volcano activity monitoring

    USGS Publications Warehouse

    Gong, W.; Meyer, F.; Webley, P.W.; Lu, Zhiming

    2011-01-01

    When a Synthetic Aperture Radar (SAR) signal propagates through the atmosphere on its path to and from the sensor, it is inevitably affected by atmospheric effects. In particular, the applicability and accuracy of Interferometric SAR (InSAR) techniques for volcano monitoring is limited by atmospheric path delays. Therefore, atmospheric correction of interferograms is required to improve the performance of InSAR for detecting volcanic activity, especially in order to advance its ability to detect subtle pre-eruptive changes in deformation dynamics. In this paper, we focus on InSAR tropospheric mitigation methods and their performance in volcano deformation monitoring. Our study areas include Okmok volcano and Unimak Island located in the eastern Aleutians, AK. We explore two methods to mitigate atmospheric artifacts, namely the numerical weather model simulation and the atmospheric filtering using Persistent Scatterer processing. We investigate the capability of the proposed methods, and investigate their limitations and advantages when applied to determine volcanic processes. ?? 2011 IEEE.

  9. Mass spectrometric monitoring of interfacial photoelectron transfer and imaging of active crystalline facets of semiconductors

    PubMed Central

    Zhong, Hongying; Zhang, Juan; Tang, Xuemei; Zhang, Wenyang; Jiang, Ruowei; Li, Rui; Chen, Disong; Wang, Peng; Yuan, Zhiwei

    2017-01-01

    Monitoring of interfacial electron transfer (ET) in situ is important to understand the ET mechanism and designing efficient photocatalysts. We describe herein a mass spectrometric approach to investigate the ultrafast transfer of photoelectrons that are generated by ultraviolet irradiation on surfaces of semiconductor nanoparticles or crystalline facets. The mass spectrometric approach can not only untargetedly detect various intermediates but also monitor their reactivity through associative or dissociative photoelectron capture dissociation, as well as electron detachment dissociation of adsorbed molecules. Proton-coupled electron transfer and proton-uncoupled electron transfer with radical initiated polymerization or hydroxyl radical abstraction have been unambiguously demonstrated with the mass spectrometric approach. Active crystalline facets of titanium dioxide for photocatalytic degradation of juglone and organochlorine dichlorodiphenyltrichloroethane are visualized with mass spectrometry imaging based on ion scanning and spectral reconstruction. This work provides a new technique for studying photo-electric properties of various materials. PMID:28224986

  10. Development of Active Control within Working Memory: Active Retrieval versus Monitoring in Children

    ERIC Educational Resources Information Center

    Blain-Brière, Bénédicte; Bouchard, Caroline; Bigras, Nathalie; Cadoret, Geneviève

    2014-01-01

    This study aimed to compare children's performance on two mnemonic functions that engage the lateral prefrontal cortex. Brain imaging studies in adults have shown that the mid-ventrolateral prefrontal cortex is specifically involved in active controlled retrieval, and the mid-dorsolateral prefrontal cortex is specifically involved in monitoring…

  11. Assessment of physical activity using wearable monitors: Measures of physical activity

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Physical activitymay be defined broadly as "all bodily actions produced by the contraction of skeletal muscle that increase energy expenditure above basal level." Physical activity is a complex construct that can be classified into major categories qualitatively, quantitatively, or contextually. The...

  12. Home-based system for physical activity monitoring in patients with multiple sclerosis (Pilot study)

    PubMed Central

    2014-01-01

    Background Limitations in physical activity are considered as a key problem in patients with multiple sclerosis (PwMS). Contemporary methods to assess the level of physical activity in PwMS are regular clinical observation. However, these methods either rely on high recall and accurate reporting from the patients (e.g. self-report questionnaires), or they are conducted during a particular clinical assessment with predefined activities. Therefore, the main aim of this pilot study was to develop an objective method to gather information about the real type and intensity of daily activities performed by PwMS in every-day living situations using an accelerometer. Furthermore, the accelerometer-derived measures are investigated regarding their potential for discriminating between different MS groups. Methods Eleven PwMS that were able to walk independently (EDSS ≤ 5) were divided into two groups: mild disability (EDSS 1–2.5; n = 6) and moderate disability (EDSS 3 –5; n = 5). Participants made use of an activity monitor device attached to their waist during their normal daily activities over 4 measurements. Activity parameters were assessed and compared for the time of each participant’s first measurement and follow-up measurement. Furthermore, differences between both subgroups, and the correlation of activity parameters with the clinical neurological variable (EDSS) were investigated. Results Participants showed significant decline in step count (p = 0.008), maximum walking speed (p = 0.02) and physical activity intensity (p = 0.03) throughout the study period. Compared to the mild subgroup, moderate affected participant accumulated less number of steps (G1: 9214.33 ± 2439.11, G2: 5018.13 ± 2416.96; p < 0.005) and were slower (G1: 1.48 ± 0.19, G2: 1.12 ± 0.44; p = 0.03). Additionally, the EDSS correlated negatively with mean walking speed (r = - 0.71, p = 0.01) and steps count (r = - 0.54, p

  13. Combining GPS with heart rate monitoring to measure physical activity in children: A feasibility study.

    PubMed

    Duncan, J Scott; Badland, Hannah M; Schofield, Grant

    2009-09-01

    The recent development of global positioning system (GPS) receivers with integrated heart rate (HR) monitoring has provided a new method for estimating the energy expenditure associated with children's movement. The purpose of this feasibility study was to trial a combination of GPS surveillance and HR monitoring in 39 primary-aged children from New Zealand. Spatial location and HR data were recorded during a school lunch break using an integrated GPS/HR receiver (1Hz). Children averaged a total distance of 1.10+/-0.56km at speeds ranging from 0 to 18.6kmh(-1). Activity patterns were characterised by short bursts of moderate to high speeds followed by longer periods of slow speeds. In addition, boys averaged higher speeds than girls (1.77+/-0.62kmh(-1) and 1.36+/-0.50kmh(-1), respectively; p=0.003). The percentage of time spent at 0kmh(-1) (stationary) ranged from 0.1% to 21.3% with a mean of 6.4+/-4.6%. These data suggest that while children were relatively active during the lunch period, they spent a substantial portion of time engaged in slow or stationary physical activities. Furthermore, associations between HR, average speed, and stationary time demonstrated that children who moved at faster speeds expended more energy than those who moved at slower speeds. We conclude that the combined approach of GPS and HR monitoring is a promising new method for investigating children's play-related energy expenditure. There is also scope to integrate GPS data with geographic information systems to examine where children play and accumulate physical activity.

  14. Asymptomatic Epstein-Barr Virus Shedding in the Urine of Kidney Transplant Recipients: Case Reports and Review of the Literature

    PubMed Central

    Rahbar, Maryam; Poormand, Gholamreza; Mahmoodi, Masoud Karkhaneh; Jazayeri, Aboozar; Jazayeri, Seyed Mohammad

    2016-01-01

    Epstein-Barr virus (EBV) is associated with a wide range of malignancies and complications like post-transplant lymphoproliferative disorder (PTLD). To suppress active EBV infection in transplant recipients, who are at a heightened risk of developing PTLD, EBV DNAemia monitoring has been recommended. Quantitative multiplex real time polymerase chain reaction (QMRTPCR) offered the advantage of detection of more than one target in the same sample. We present four cases of kidney transplant recipient who were admitted for rising serum creatinine between 9 and 20 months post-transplant with a suspicion of BKV-associated nephropathy. All but one patient had unusual sonography findings in their genitourinary tracts and were positive for urinary culture for bacteria. Using a commercial QMRTPCR that could detect and quantitate BKV, EBV and cytomegalovirus simultaneously, all patients were positive for EBV in their urine for the levels between 2500 and 8×108 U/mL. None of the patients had any symptoms regarding this finding. On following up survey 3 month post discharge from hospital, all patients were negative for plasma and urine EBV. Absent of EBV DNAemia together with alternating phases of detectable EBV in urine might reflect the presence of functionally efficient central/effector memory T cells against EBV. The significance of this finding in immunocompromized patients necessitates prospective longitudinal studies. PMID:28191298

  15. VEPP Exercise: Volcanic Activity and Monitoring of Pu`u `O`o, Kilauea Volcano, Hawaii

    NASA Astrophysics Data System (ADS)

    Rodriguez, L. A.

    2010-12-01

    A 10-week project will be tested during the Fall semester 2010, for a Volcanic Hazards elective course, for undergraduate Geology students of the University of Puerto Rico at Mayaguez. This exercise was developed during the Volcanoes Exploration Project: Pu`u `O`o (VEPP) Workshop, held on the Big Island of Hawaii in July 2010. For the exercise the students will form groups (of 2-4 students), and each group will be assigned a monitoring technique or method, among the following: seismic (RSAM data), deformation (GPS and tilt data), observations (webcam and lava flow maps), gas and thermal monitoring. The project is designed for Geology undergraduates who have a background in introductory geology, types of volcanoes and eruptions, magmatic processes, characteristics of lava flows, and other related topics. It is divided in seven tasks, starting with an introduction and demonstration of the VEPP website and the VALVE3 software, which is used to access monitoring data from the current eruption of Pu`u `O`o, Kilauea volcano, Hawaii. The students will also familiarize themselves with the history of Kilauea volcano and its current eruption. At least weekly the groups will acquire data (mostly near-real-time) from the different monitoring techniques, in the form of time series, maps, videos, and images, in order to identify trends in the data. The groups will meet biweekly in the computer laboratory to work together in the analysis and interpretation of the data, with the support of the instructor. They will give reports on the progress of the exercise, and will get feedback from the instructor and from the other expert groups. All groups of experts will relate their findings to the recent and current activity of Kilauea volcano, and the importance of their specific type of monitoring. The activity will culminate with a written report and an oral presentation. The last task of the project consists of a wrap-up volcano monitoring exercise, in which the students will

  16. Patterns of physical activity determined by heart rate monitoring among diabetic children

    PubMed Central

    Massin, M; Lebrethon, M; Rocour, D; Gerard, P; Bourguignon, J

    2005-01-01

    Background: Children with type 1 diabetes should be encouraged to participate in physical activity because exercise can benefit insulin sensitivity and improve known risk factors for atherosclerosis. Methods: Physical activity patterns of 127 children and adolescents with stable type 1 diabetes were investigated by 24 hour continuous heart rate monitoring. The percentage of heart rate reserve was used to measure the amounts of physical activity at different intensities. The results were compared with normative data. Results: Diabetic preschoolchildren accumulated 192.7 (78.1), 39.1 (24.3), and 21.3 (9.4) minutes/day (mean (SD)) of light, moderate, and vigorous physical activity, respectively. At the same activity levels, diabetic schoolchildren accumulated 168.9 (76.7), 37.9 (15.9), and 19.0 (14.8) minutes/day, and diabetic teenagers accumulated 166.3 (67.5), 45.6 (26.9), and 25.2 (15.3) minutes/day. Diabetic schoolchildren were significantly more active than healthy peers when considering moderate activity; diabetic teenagers were significantly more active when considering moderate and vigorous activity. There was a negative correlation between the most recent glycated haemoglobin and the time spent in light activities in schoolchildren, and a negative correlation between mean glycated haemoglobin for one year and time spent in light and moderate activities in schoolchildren. Conclusion: The majority of our diabetic patients meet the classical paediatric guidelines for physical activity and compare favourably with their healthy peers. PMID:15941770

  17. Capturing PLMS and their variability in children with sickle cell disease: Does ankle activity monitoring measure up to polysomnography?

    PubMed Central

    Gallagher, Paul R.; Marcus, Carole L.; Ohene-Frempong, Kwaku; Traylor, Joel T.; Mason, Thornton B. A.

    2015-01-01

    Objectives To test agreement and define differences in periodic limb movements in sleep (PLMS) measured by polysomnography and an ankle activity monitor, and to describe PLMS variability across nights, feasibility of home monitoring, and correlates of PLMS in children with sickle cell disease (SCD). Methods Twenty children with SCD and restless legs syndrome (RLS) symptoms or polysomnography-documented PLMS underwent concurrent attended polysomnography and ankle activity monitoring over 1–2 nights and home activity monitoring for 3 nights. Serum iron and ferritin were measured pre- and post-polysomnography. Results Adequate sensitivity (1.00), specificity (0.69), and mean bias (5.0±7.4 PLMS/h) for identifying elevated PLMS by activity monitor were obtained when scoring the period from sleep onset to offset rather than time in bed per manufacturer recommendation, and using a cut-point of 10 PLMS/h. Compared to activity monitor, only polysomnographic PLMS demonstrated periodicity, at inter-movement intervals (IMI) 20–35 s; the activity monitor overscored PLMS at the beginning and end of sleep and at shorter IMI (5–15 s; p≤0.003), suggesting misclassification of nonperiodic leg movements as PLMS by activity monitor. PLMS varied across 4 nights by 16.1±13.4 PLMS/h. Post-polysomnography ferritin was associated (positively) with PLMS (p=0.034); RLS symptoms were not. Conclusions Ankle activity monitoring is a valid screening measure for PLMS in children with SCD and can readily be performed at home. Interpretation should incorporate a threshold for elevated PLMS of 10/h and scoring from sleep onset to offset which could be identified with concurrent wrist actigraphy, to better account for true PLMS. PMID:22841030

  18. Quality of life and energy expenditure in transplant recipient football players.

    PubMed

    Totti, V; Zancanaro, M; Trerotola, M; Nanni Costa, A; Antonetti, T; Anedda, A; Roi, G S

    2013-09-01

    Football (soccer) is a highly motivating leisure activity with important potential as a health-promoting activity also for transplant recipients. The aim of this study was to assess the "on the field" energy expenditure during football games and the quality of life of transplant recipients practicing football. Twenty-two recipients of kidney (n = 11), bone marrow (n = 7), liver (n = 3) or corneal (n = 1) transplantations had an overall mean age of 37 ± 9 years, body mass index of 23.5 ± 2.4 kg/m(2), and time after transplantation of 9.3 ± 6.4 years. They were compared with 25 healthy football players of mean age 41 ± 10 years and body mass index of 26.3 ± 3.9 kg/m(2). There were no significant differences between transplant recipients and controls regarding mean energy expenditure (393 ± 113 vs 392 ± 132 kcal/h) number of steps (3.978 ± 1.317 vs 3.933 ± 1.563) during, and capillary blood lactate concentrations (4.8 ± 0.9 vs 5.2 ± 1.3 mmol/L) after the matches. The SF-36 questionnaire administered before the matches showed transplant recipient players to score significantly worse in the scales of general (P < .05) and mental health (P < .01). This study indicated that transplant recipients involved in football matches attained a level of energy expenditure and a quality of life consistent with a healthy lifestyle. Football has the potential to be implemented as a permanent health-promoting activity also for transplant recipients.

  19. 76 FR 19683 - Conservation Program Recipient Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... Conservation Service 7 CFR Parts 622, 624 and 625 Commodity Credit Corporation 7 CFR Parts 1465 and 1470 RIN 0578-AA56 Conservation Program Recipient Reporting AGENCY: Natural Resources Conservation Service... Conservation Stewardship Program have application or plan due dates after October 1, 2010, and therefore,...

  20. 40 CFR 35.663 - Eligible recipients.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Eligible recipients. 35.663 Section 35.663 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Pollution Prevention Grants...

  1. 40 CFR 35.663 - Eligible recipients.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Eligible recipients. 35.663 Section 35.663 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Pollution Prevention Grants...

  2. 47 CFR 54.630 - Eligible recipients.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SERVICE Universal Service Support for Health Care Providers Healthcare Connect Fund § 54.630 Eligible recipients. (a) Rural health care provider site—individual and consortium. Under the Healthcare Connect Fund... or through a consortium. For purposes of the Healthcare Connect Fund, a “consortium” is a group...

  3. 47 CFR 54.630 - Eligible recipients.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SERVICE Universal Service Support for Health Care Providers Healthcare Connect Fund § 54.630 Eligible recipients. (a) Rural health care provider site—individual and consortium. Under the Healthcare Connect Fund... or through a consortium. For purposes of the Healthcare Connect Fund, a “consortium” is a group...

  4. 20 CFR 435.41 - Recipient responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Recipient responsibilities. 435.41 Section 435.41 Employees' Benefits SOCIAL SECURITY ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT...

  5. 20 CFR 634.3 - Eligible recipients.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR LABOR MARKET INFORMATION PROGRAMS UNDER TITLE IV, PART E OF THE JOB TRAINING PARTNERSHIP ACT Comprehensive Labor Market Information System § 634.3 Eligible recipients. (a) For funds appropriated pursuant to JTPA title IV, part...

  6. 31 CFR 208.8 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Recipient responsibilities. 208.8 Section 208.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE MANAGEMENT OF FEDERAL...

  7. Recipient twin limb ischemia with postnatal onset.

    PubMed

    Broadbent, Roland Spencer

    2007-02-01

    After the occurrence of 3 local cases of limb ischemia in newborn twins, we reviewed the literature to investigate this combination systematically. This review reveals a distinct condition: postnatal onset limb ischemia affecting recipient twins in twin-twin transfusion syndrome.

  8. 34 CFR 74.41 - Recipient responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Recipient responsibilities. 74.41 Section 74.41 Education Office of the Secretary, Department of Education ADMINISTRATION OF GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award...

  9. 24 CFR 84.41 - Recipient responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Recipient responsibilities. 84.41 Section 84.41 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF...

  10. 24 CFR 84.41 - Recipient responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Recipient responsibilities. 84.41 Section 84.41 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF...

  11. 22 CFR 226.41 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Recipient responsibilities. 226.41 Section 226.41 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.41...

  12. 22 CFR 226.41 - Recipient responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Recipient responsibilities. 226.41 Section 226.41 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.41...

  13. 22 CFR 226.41 - Recipient responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Recipient responsibilities. 226.41 Section 226.41 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.41...

  14. 24 CFR 84.41 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Recipient responsibilities. 84.41 Section 84.41 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF...

  15. 22 CFR 226.41 - Recipient responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Recipient responsibilities. 226.41 Section 226.41 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.41...

  16. 24 CFR 84.41 - Recipient responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Recipient responsibilities. 84.41 Section 84.41 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF...

  17. 24 CFR 84.41 - Recipient responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Recipient responsibilities. 84.41 Section 84.41 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF...

  18. 10 CFR 603.210 - Recipients.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-profit partner or partners who plan on being involved in the commercial application of the results. (ii... performers and their for-profit partner to ensure that the for-profit partner is committed to being involved... partners in the performance of the project than usually is the case with a prime recipient...

  19. 22 CFR 145.41 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Recipient responsibilities. 145.41 Section 145.41 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements...

  20. 25 CFR 41.4 - Eligible recipients.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION GRANTS TO TRIBALLY CONTROLLED COMMUNITY COLLEGES AND NAVAJO COMMUNITY COLLEGE Tribally Controlled Community Colleges § 41.4 Eligible recipients. Financial assistance under this subpart shall be available only to a Community College which: (a) Is governed by...

  1. 7 CFR 25.602 - Eligible recipients.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Eligible recipients. 25.602 Section 25.602 Agriculture Office of the Secretary of Agriculture RURAL EMPOWERMENT ZONES AND ENTERPRISE COMMUNITIES Round II and... made to the lead managing entities on behalf of the Round II rural empowerment zones and Round...

  2. 15 CFR 14.41 - Recipient responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Recipient responsibilities. 14.41 Section 14.41 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... DoC, regarding the settlement and satisfaction of all contractual and administrative issues...

  3. 15 CFR 14.41 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Recipient responsibilities. 14.41 Section 14.41 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... DoC, regarding the settlement and satisfaction of all contractual and administrative issues...

  4. 15 CFR 14.41 - Recipient responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Recipient responsibilities. 14.41 Section 14.41 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... DoC, regarding the settlement and satisfaction of all contractual and administrative issues...

  5. 15 CFR 14.41 - Recipient responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Recipient responsibilities. 14.41 Section 14.41 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... DoC, regarding the settlement and satisfaction of all contractual and administrative issues...

  6. 15 CFR 14.41 - Recipient responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Recipient responsibilities. 14.41 Section 14.41 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... DoC, regarding the settlement and satisfaction of all contractual and administrative issues...

  7. 40 CFR 30.41 - Recipient responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Recipient responsibilities. 30.41 Section 30.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards §...

  8. 40 CFR 30.41 - Recipient responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Recipient responsibilities. 30.41 Section 30.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards §...

  9. 40 CFR 30.41 - Recipient responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Recipient responsibilities. 30.41 Section 30.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards §...

  10. 40 CFR 30.41 - Recipient responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Recipient responsibilities. 30.41 Section 30.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards §...

  11. 20 CFR 634.3 - Eligible recipients.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR LABOR MARKET INFORMATION PROGRAMS UNDER TITLE IV, PART E OF THE JOB TRAINING PARTNERSHIP ACT Comprehensive Labor Market Information System § 634.3 Eligible recipients. (a) For funds appropriated pursuant to JTPA title IV, part...

  12. Hyperthyroidism in a renal transplant recipient.

    PubMed

    Peces, R; Navascués, R A; Baltar, J; Laurés, A S; Ortega, F; Alvarez-Grande, J

    1998-01-01

    We report a case of toxic multinodular goiter with severe symptomatic hyperthyroidism in a female diagnosed 5 months after successful renal transplantation. To our knowledge, this is the first well-documented case of hyperthyroidism in a renal transplant recipient that responded well to methimazole. Special attention should be made to the use of methimazole and the possible interaction with immunosuppressive drugs.

  13. 47 CFR 54.501 - Eligible recipients.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Only schools meeting the statutory definition of “elementary school” or “secondary school” as defined... whose budgets are completely separate from any schools (including, but not limited to, elementary and... Eligible recipients. (a) * * * (1) Only schools meeting the statutory definition of “elementary school”...

  14. 47 CFR 54.501 - Eligible recipients.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICE Universal Service Support for Schools and Libraries § 54.501 Eligible recipients. (a) Schools. (1... discounts under this subpart. (b) Libraries. (1) Only libraries eligible for assistance from a State library administrative agency under the Library Services and Technology Act (Pub. L. 104-208) and not excluded...

  15. 78 FR 57668 - U.S. Nuclear Regulatory Commission Planned for Monitoring Activities for the Saltstone Disposal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ... responsibilities for monitoring DOE's waste disposal activities at the Saltstone Disposal Facility (SDF) at the... Evaluation Report (TER) for the SDF in December 2005, as part of the NRC consultation with DOE in its waste... Revision 0 of the SDF Monitoring Plan based on the 2005 NRC TER and the DOE final waste determination....

  16. Activation and implementation of a Federal Radiological Monitoring and Assessment Center

    SciTech Connect

    Doyle, J.F. III

    1989-01-01

    The Nevada Operations Office of the U.S. Department of Energy (DOE/NV) has been assigned the primary responsibility for responding to a major radiological emergency. The initial response to any radiological emergency, however, will probably be conducted under the DOE regional radiological assistance plan (RAP). If the dimensions of the crisis demand federal assistance, the following sequence of events may be anticipated: (1) DOE regional RAP response, (2) activation of the Federal Radiological Monitoring and Assistance Center (FRMAC) requested, (3) aerial measuring systems and DOE/NV advance party respond, (4) FRMAC activated, (5) FRMAC responds to state(s) and cognizant federal agency (CFA), and (6) management of FRMAC transferred to the Environmental Protection Agency (EPA). The paper discusses activation channels, authorization, notification, deployment, and interfaces.

  17. Objective evaluation of stress with the blind by the monitoring of autonomic nervous system activity.

    PubMed

    Massot, Bertrand; Baltenneck, Nicolas; Gehin, Claudine; Dittmar, Andre; McAdams, Eric

    2010-01-01

    Accessibility for the blind in an urban space must be studied under real conditions in their daily environment. A new approach for evaluating the impact of environmental conditions on blind pedestrians is the objective measure of stress by the monitoring of the autonomic nervous system (ANS) activity. Original techniques of data analysis and spatial representation are proposed for the detection of the ANS activity through the assessment of the electrodermal activity. Skin resistance was recorded with an EmoSense system on 10 blind subjects who followed a charted course independently. The course was 1065 meters long and consisted of various environmental conditions in an urban space. The spatial frequency of the non-specific skin resistance responses was used to provide a more relevant representation of geographic hotspots. Results of statistical analysis based on this new parameter are discussed to conclude on phenomena causing mental stress with the blind moving in an urban space.

  18. Monitoring seasonal bat activity on a coastal barrier island in Maryland, USA.

    PubMed

    Johnson, Joshua B; Gates, J Edward; Zegre, Nicolas P

    2011-02-01

    Research on effects of wind turbines on bats has increased dramatically in recent years because of significant numbers of bats killed by rotating wind turbine blades. Whereas most research has focused on the Midwest and inland portions of eastern North America, bat activity and migration on the Atlantic Coast has largely been unexamined. We used three long-term acoustic monitoring stations to determine seasonal bat activity patterns on the Assateague Island National Seashore, a barrier island off the coast of Maryland, from 2005 to 2006. We recorded five species, including eastern red bats (Lasiurus borealis), big brown bats (Eptesicus fuscus), hoary bats (Lasiurus cinereus), tri-colored bats (Perimyotis subflavus), and silver-haired bats (Lasionycteris noctivagans). Seasonal bat activity (number of bat passes recorded) followed a cosine function and gradually increased beginning in April, peaked in August, and declined gradually until cessation in December. Based on autoregressive models, inter-night bat activity was autocorrelated for lags of seven nights or fewer but varied among acoustic monitoring stations. Higher nightly temperatures and lower wind speeds positively affected bat activity. When autoregressive model predictions were fitted to the observed nightly bat pass totals, model residuals>2 standard deviations from the mean existed only during migration periods, indicating that periodic increases in bat activity could not be accounted for by seasonal trends and weather variables alone. Rather, the additional bat passes were attributable to migrating bats. We conclude that bats, specifically eastern red, hoary, and silver-haired bats, use this barrier island during migration and that this phenomenon may have implications for the development of near and offshore wind energy.

  19. Associations of Monitor-Assessed Activity with Performance-Based Physical Function

    PubMed Central

    Reid, Natasha; Daly, Robin M.; Winkler, Elisabeth A. H.; Gardiner, Paul A.; Eakin, Elizabeth G.; Owen, Neville; Dunstan, David W.; Healy, Genevieve N.

    2016-01-01

    The purpose of this study was to investigate the cross-sectional associations of monitor-derived measures of sedentary time and physical activity with performance-based physical function in healthy Australian adults. Data from 602 participants (mean age 58.1±10.0 years; 58% female) from the 2011/12 wave of the Australian Diabetes, Obesity and Lifestyle (AusDiab3) study were analyzed. The thigh-worn activPAL3™ monitor (7-days continuous wear) was used to derive time during waking hours spent: sitting/reclining; standing; and, stepping (overall, and separately as light [<3 METs] and moderate-to-vigorous physical activity [MVPA; ≥3 METs]), and number of sit-stand transitions. Associations of these (in hours/day, or 15 transitions/day) with physical function measures (8ft Timed Up and Go [TUG-8; log-transformed seconds] and Knee Extensor Strength [KES; kg]) were tested via linear regression, adjusting for confounders. Interactions by sex and age-category (<45; 45–54; 55–64; ≥65 years) were tested. In all participants, KES was significantly (p<0.05) associated with stepping and MVPA stepping only; none of the activity measures were associated with TUG-8. However, subgroup analysis revealed that in older adults (≥65 years), TUG-8 was associated with stepping and MVPA stepping (both p<0.05). All associations with sitting time, standing, sit-stand transition and sex interactions were not statistically significant. In summary, sitting time was not significantly associated with impaired muscle strength or gait/mobility in Australian adults aged 36–80 years, but light- to moderate activity (stepping) was positively associated with muscle strength, and gait/mobility in older adults aged ≥65 years. The direction of causation is not known and remains important to investigate considering the high prevalence of both poor function and limited activity in older age. PMID:27073888

  20. Cutaneous cryptococcosis in solid organ transplant recipients.

    PubMed

    Sun, Hsin-Yun; Alexander, Barbara D; Lortholary, Olivier; Dromer, Francoise; Forrest, Graeme N; Lyon, G Marshall; Somani, Jyoti; Gupta, Krishan L; Del Busto, Ramon; Pruett, Timothy L; Sifri, Costi D; Limaye, Ajit P; John, George T; Klintmalm, Goran B; Pursell, Kenneth; Stosor, Valentina; Morris, Michele I; Dowdy, Lorraine A; Muñoz, Patricia; Kalil, Andre C; Garcia-Diaz, Julia; Orloff, Susan L; House, Andrew A; Houston, Sally H; Wray, Dannah; Huprikar, Shirish; Johnson, Leonard B; Humar, Atul; Razonable, Raymund R; Fisher, Robert A; Husain, Shahid; Wagener, Marilyn M; Singh, Nina

    2010-09-01

    Clinical manifestations, treatment, and outcomes of cutaneous cryptococcosis in solid organ transplant (SOT) recipients are not fully defined. In a prospective cohort comprising 146 SOT recipients with cryptococcosis, we describe the presentation, antifungal therapy, and outcome of cutaneous cryptococcal disease. Cutaneous cryptococcosis was documented in 26/146 (17.8%) of the patients and manifested as nodular/mass (34.8%), maculopapule (30.4%), ulcer/pustule/abscess (30.4%), and cellulitis (30.4%) with 65.2% of the skin lesions occurred in the lower extremities. Localized disease developed in 30.8% (8/26), and disseminated disease in 69.2% (18/26) with involvement of the central nervous system (88.9%, 16/18), lung (33.3%, 6/18), or fungemia (55.6%, 10/18). Fluconazole (37.5%) was employed most often for localized and lipid formulations of amphotericin B (61.1%) for disseminated disease. Overall mortality at 90 days was 15.4% (4/26) with 16.7% in disseminated and 12.5% in localized disease (P = 0.78). SOT recipients who died were more likely to have renal failure (75.0% vs. 13.6%, P = 0.028), longer time to onset of disease after transplantation (87.5 vs. 22.6 months, P = 0.023), and abnormal mental status (75% vs. 13.6%, P = 0.028) than those who survived. Cutaneous cryptococcosis represents disseminated disease in most SOT recipients and preferentially involves the extremities. Outcomes with appropriate management were comparable between SOT recipients with localized and disseminated cryptococcosis.