Science.gov

Sample records for activities reported include

  1. Activity report

    SciTech Connect

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  2. Annual report of the National Advisory Committee for Aeronautics (42nd). administrative report including Technical Report nos. 1254 to 1295

    NASA Technical Reports Server (NTRS)

    1957-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  3. Annual report of the National Advisory Committee for Aeronautics (37th). administrative report including Technical Report nos. 1003 to 1031

    NASA Technical Reports Server (NTRS)

    1952-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  4. Annual report of the National Advisory Committee for Aeronautics (34th). administrative report including Technical Report nos. 892 to 921

    NASA Technical Reports Server (NTRS)

    1951-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  5. Annual report of the National Advisory Committee for Aeronautics (40th). administrative report including Technical Report nos. 1158-1209

    NASA Technical Reports Server (NTRS)

    1956-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  6. Annual report of the National Advisory Committee for Aeronautics (35th). administrative report including Technical Report nos. 922 to 950

    NASA Technical Reports Server (NTRS)

    1951-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  7. Annual report of the National Advisory Committee for Aeronautics (41st). administrative report including Technical Report nos. 1210 to 1253

    NASA Technical Reports Server (NTRS)

    1957-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  8. Annual report of the National Advisory Committee for Aeronautics (38th). administrative report including Technical Report nos. 1059 to 1110

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  9. Annual report of the National Advisory Committee for Aeronautics (36th). administrative report including Technical Report nos. 951 to 1002

    NASA Technical Reports Server (NTRS)

    1951-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  10. Annual report of the National Advisory Committee for Aeronautics (29th) : administrative report including Technical Report nos. 752 to 773

    NASA Technical Reports Server (NTRS)

    1948-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  11. Annual Report of the National Advisory Committee for Aeronautics (1st). [Administrative Report Including Technical Reports Nos. 1 to 7

    NASA Technical Reports Server (NTRS)

    1916-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations, and a compilation of technical reports produced.

  12. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  13. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  14. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  15. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  16. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  17. LANSCE Activity Report

    SciTech Connect

    Amy Robinson; Audrey Archuleta; Barbara Maes; Dan Strottman; Earl Hoffman; Garth Tietjen; Gene Farnum; Geoff Greene; Joyce Roberts; Ken Johnson; Paul Lewis; Roger Pynn; Stan Schriber; Steve Sterbenz; Steve Wender; Sue Harper

    1999-02-01

    The Los Alamos Neutron Science Center Activity Report describes scientific and technological progress and achievements in LANSCE Division during the period of 1995 to 1998. This report includes a message from the Division Director, an overview of LANSCE, sponsor overviews, research highlights, advanced projects and facility upgrades achievements, experimental and user program accomplishments, news and events, and a list of publications. The research highlights cover the areas of condensed-matter science and engineering, accelerator science, nuclear science, and radiography. This report also contains a compact disk that includes an overview, the Activity Report itself, LANSCE operations progress reports for 1996 and 1997, experiment reports from LANSCE users, as well as a search capability.

  18. Annual report of the National Advisory Committee for Aeronautics (18th).administrative report including Technical Report nos. 401 to 440

    NASA Technical Reports Server (NTRS)

    1933-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  19. Annual report for the National Advisory Committee for Aeronautics (10th).administrative report including Technical Reports nos. 186 to 209

    NASA Technical Reports Server (NTRS)

    1925-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  20. Annual report of the National Advisory Committee for Aeronautics (16th).administrative report including Technical Reports nos. 337 to 364

    NASA Technical Reports Server (NTRS)

    1931-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  1. Annual report of the National Advisory Committee for Aeronautics (17th).administrative report including Technical Report nos. 365 to 400

    NASA Technical Reports Server (NTRS)

    1932-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  2. Annual report of the National Advisory Committee for Aeronautics (15th).administrative report including Technical Reports nos. 309 to 336

    NASA Technical Reports Server (NTRS)

    1930-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  3. Annual report of the National Advisory Committee for Aeronautics (21st).administrative report including Technical Report nos. 508 to 541

    NASA Technical Reports Server (NTRS)

    1936-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  4. Annual report of the National Advisory Committee for Aeronautics (14th).administrative report including Technical Reports nos. 283 to 308

    NASA Technical Reports Server (NTRS)

    1929-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  5. Annual report of the National Advisory Committee for Aeronautics (13th).administrative report including Technical Reports nos. 257 to 282

    NASA Technical Reports Server (NTRS)

    1928-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  6. Annual report for the National Advisory Committee for Aeronautics (11th).administrative report including Technical Reports nos. 210 to 232

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  7. Annual report for the National Advisory Committee for Aeronautics (12th).administrative report including Technical Reports nos. 233 to 256

    NASA Technical Reports Server (NTRS)

    1927-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  8. Annual report of the National Advisory Committee for Aeronautics (19th).administrative report including Technical Report nos. 441 to 474

    NASA Technical Reports Server (NTRS)

    1934-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  9. Annual report of the National Advisory Committee for Aeronautics (22nd).administrative report including Technical Report nos. 542 to 576

    NASA Technical Reports Server (NTRS)

    1937-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  10. Annual report of the National Advisory Committee for Aeronautics (20th).administrative report including Technical Report nos. 475 to 507

    NASA Technical Reports Server (NTRS)

    1935-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  11. Annual report of the National Advisory Committee for Aeronautics (33rd).administrative report including Technical Report nos. 863 to 891

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  12. Annual Report of the National Advisory Committee for Aeronautics (9Th).Administrative Report Including Technical Reports Nos. 159 to 185

    NASA Technical Reports Server (NTRS)

    1924-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, and expenditures.

  13. Annual report of the National Advisory Committee for Aeronautics (8th).administrative report including Technical Reports nos. 133 to 158

    NASA Technical Reports Server (NTRS)

    1923-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, congressional report, summaries of the committee's activities and research accomplished, and expenditures.

  14. Annual report of the National Advisory Committee for Aeronautics (32nd).administative report including Technical Report nos. 834 to 862

    NASA Technical Reports Server (NTRS)

    1949-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  15. Annual report of the National Advisory Committee for Aeronautics (28th).administrative report including Technical Report nos. 727 to 751

    NASA Technical Reports Server (NTRS)

    1946-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  16. Annual report of the National Advisory Committee for Aeronautics (26th).administrative report including Technical Report nos. 681 to 703

    NASA Technical Reports Server (NTRS)

    1941-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  17. Annual report of the National Advisory Committee for Aeronautics (23rd).administrative report including Technical Report nos. 577 to 611

    NASA Technical Reports Server (NTRS)

    1937-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  18. Annual report of the National Advisory Committee for Aeronautics (24th).administrative report including Technical Report nos. 612 to 644

    NASA Technical Reports Server (NTRS)

    1939-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  19. Annual report of the National Advisory Committee for Aeronautics (25th).administrative report including Technical Report nos. 645 to 680

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  20. Annual report of the National Advisory Committee for Aeronautics (7th).administrative report including Technical Reports nos. 111 to 132

    NASA Technical Reports Server (NTRS)

    1923-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, and expenditures.

  1. Annual report of the National Advisory Committee for Aeronautics (30th).administrative report including Technical Report nos. 774 to 803

    NASA Technical Reports Server (NTRS)

    1949-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of Committee's activities and research accomplished, bibliographies, and financial report.

  2. Annual Report of the National Advisory Committee for Aeronautics (27Th).Administrative Report Including Technical Report Nos. 704 to 726

    NASA Technical Reports Server (NTRS)

    1942-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  3. Annual report of the National Advisory Committee for Aeronautics (5th).administrative report including Technical Reports nos. 51 to 82

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, and a compilation of technical reports produced.

  4. Annual report of the National Advisory Committee for Aeronautics (4th).administrative report including Technical Reports nos. 24 to 50

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations, and a compilation of technical reports produced.

  5. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  6. Including indigenous knowledge and experience in IPCC assessment reports

    NASA Astrophysics Data System (ADS)

    Ford, James D.; Cameron, Laura; Rubis, Jennifer; Maillet, Michelle; Nakashima, Douglas; Willox, Ashlee Cunsolo; Pearce, Tristan

    2016-04-01

    The IPCC is the leading international body for the assessment of climate change, forming the interface between science, policy and global politics. Indigenous issues have been under-represented in previous IPCC assessments. In this Perspective, we analyse how indigenous content is covered and framed in the Working Group II (WGII) portion of the Fifth Assessment Report (AR5). We find that although there is reference to indigenous content in WGII, which increased from the Fourth Assessment Report, the coverage is general in scope and limited in length, there is little critical engagement with indigenous knowledge systems, and the historical and contextual complexities of indigenous experiences are largely overlooked. The development of culturally relevant and appropriate adaptation policies requires more robust, nuanced and appropriate inclusion and framing of indigenous issues in future assessment reports, and we outline how this can be achieved.

  7. Annual report of the National Advisory Committee for Aeronautics (6th).administrative report including Technical Reports nos. 83 to 110

    NASA Technical Reports Server (NTRS)

    1921-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, House of Representatives bill 14061, a copy of the bill introduced to the House of Representatives to regulate air navigation, and a compilation of technical reports produced.

  8. Information for Teachers (Including Classroom Activities), Skylab Student Project.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This program is intended to directly involve the educational community in space experiments, many of which can be related to existing curricula. Included in this first packet are: 1) a brief description of the Skylab Program and the National Science Teachers Association-National Aeronautics and Space Administration (NSTA-NASA) Skylab Student…

  9. Annual report of the National Advisory Committee for Aeronautics (2nd) together with the message of the President of the United States transmitting the report for the fiscal year ending June 30, 1916. administrative report including technical report

    NASA Technical Reports Server (NTRS)

    1917-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations and a compilation of technical reports produced.

  10. 77 FR 17488 - Amendment to Proposed Collection: Comment Request Post-Award Reporting Requirements Including New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-26

    ...-Award Reporting Requirements Including New Research Performance Progress Report Collection The 60-day... Policy for Extramural Research Administration, Office of Extramural Research, National Institutes...

  11. NSLS 2009 Activity Report

    SciTech Connect

    Nasta K.; Mona R.

    2009-05-01

    2009 was an incredibly exciting year for light sources at Brookhaven. The National Synchrotron Light Source (NSLS) hosted more than 2,200 visiting researchers, who, along with the about 50 members of our scientific staff, produced a total of 957 publications - about 20 percent of which appeared in premier journals. Covering topics ranging from Alzheimer's disease detection to ethanol-powered fuel cells, a sampling of these findings can be found in this Activity Report. We've also seen the resurfacing of some of our long-time users hard work. I was very proud to hear that two of the three recipients of the 2009 Nobel Prize in Chemistry have ties to the NSLS. Venki Ramakrishnan, a former employee in Brookhaven's biology department and long-time user of the NSLS, now at Cambridge University, and Thomas A. Steitz of Yale University, also a long-time NSLS user, shared the prize with Ada E. Yonath of the Weizmann Institute of Science for their work on the structure and function of the ribosome. In the late 1990s, Ramakrishnan and Steitz used protein crystallography at the NSLS to gather atomic-level images of two ribosome subunits: 30S (Ramakrishnan) and 50S (Steitz). Both laureates solved the high-resolution structures for these subunits based on this data. After struggling with a rough budget for several years, we received excellent funding, and then some, this year. In addition to NSLS operations funding, we received $3 million in funds from the American Recovery and Reinvestment Act (ARRA). We used that additional money for two exciting projects: construction of a full-field x-ray microscope and acquisition of several advanced x-ray detectors. The x-ray microscope will be able to image objects with a targeted spatial resolution of 30 nanometers. This capability will be particularly important for new initiatives in energy research and will prepare our users for the projected 1-nanometer resolution benchmark at the National Synchrotron Light Source II (NSLS-II). The

  12. 33 CFR 169.140 - What information must be included in the report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Mandatory Ship Reporting Systems for the Protection of Northern Right Whales § 169.140 What information must be included in the report? Each ship report made to the shore-based authority must follow...

  13. 33 CFR 169.140 - What information must be included in the report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Mandatory Ship Reporting Systems for the Protection of Northern Right Whales § 169.140 What information must be included in the report? Each ship report made to the shore-based authority must follow...

  14. 33 CFR 169.140 - What information must be included in the report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Mandatory Ship Reporting Systems for the Protection of Northern Right Whales § 169.140 What information must be included in the report? Each ship report made to the shore-based authority must follow...

  15. 33 CFR 169.140 - What information must be included in the report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Mandatory Ship Reporting Systems for the Protection of Northern Right Whales § 169.140 What information must be included in the report? Each ship report made to the shore-based authority must follow...

  16. 33 CFR 169.140 - What information must be included in the report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Mandatory Ship Reporting Systems for the Protection of Northern Right Whales § 169.140 What information must be included in the report? Each ship report made to the shore-based authority must follow...

  17. 40 CFR 60.2956 - What information must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... annual report? 60.2956 Section 60.2956 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... and Qualification Recordkeeping and Reporting § 60.2956 What information must I include in my annual report? The annual report required under § 60.2955 must include the ten items listed in paragraphs...

  18. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... annual report? 60.2770 Section 60.2770 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... must I include in my annual report? The annual report required under § 60.2765 must include the ten... parameter recorded for the calendar year being reported. (g) Information recorded under § 60.2740(b)(6)...

  19. 40 CFR 62.14730 - What information must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... information must I include in my annual report? The annual report required under § 62.14725 must include the... annual report? 62.14730 Section 62.14730 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... applicable, for each operating parameter recorded for the calendar year being reported. (g)...

  20. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., 2001 Recordkeeping and Reporting § 60.2210 What information must I include in my annual report? The annual report required under § 60.2205 must include the ten items listed in paragraphs (a) through (j) of... annual report? 60.2210 Section 60.2210 Protection of Environment ENVIRONMENTAL PROTECTION...

  1. 25 CFR 183.16 - What information must be included in the Tribe's annual report?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... LEASE FUND Reports § 183.16 What information must be included in the Tribe's annual report? The Tribe's annual report must contain the following information: (a) An accounting of the expenditures of funds... 25 Indians 1 2010-04-01 2010-04-01 false What information must be included in the Tribe's...

  2. Technical planning activity: Final report

    SciTech Connect

    Not Available

    1987-01-01

    In April 1985, the US Department of Energy's (DOE's) Office of Fusion Energy commissioned the Technical Planning Activity (TPA). The purpose of this activity was to develop a technical planning methodology and prepare technical plans in support of the strategic and policy framework of the Magnetic Fusion Program Plan issued by DOE in February 1985. Although this report represents the views of only the US magnetic fusion community, it is international in scope in the sense that the technical plans contained herein describe the full scope of the tasks that are prerequisites for the commercialization of fusion energy. The TPA has developed a well-structured methodology that includes detailed definitions of technical issues, definitions of program areas and elements, statements of research and development objectives, identification of key decision points and milestones, and descriptions of facility requirements.

  3. ALS Activity Report 2004

    SciTech Connect

    Tamura , Lori S.

    2005-07-11

    This annual report of the Advanced Light Source details science highlights and facility developments during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  4. 40 CFR 60.3051 - What information must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... annual report? 60.3051 Section 60.3051 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... annual report? The annual report required under § 60.3050 must include the ten items listed in paragraphs... each operating parameter recorded for the calendar year being reported. (g) Information recorded...

  5. 40 CFR 60.1875 - What must I include in my initial report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false What must I include in my initial...-Reporting § 60.1875 What must I include in my initial report? You must include seven items: (a) The emission... all of the following five pollutants or parameters as recorded in accordance with § 60.1850(b)....

  6. Advanced Light Source Activity Report 2000

    SciTech Connect

    Greiner, A.; Moxon, L.; Robinson, A.; Tamura, L.

    2001-04-01

    This is an annual report, detailing activities at the Advanced Light Source for the year 2000. It includes highlights of scientific research by users of the facility as well as information about the development of the facility itself.

  7. 75 FR 34170 - Circuit Science, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... Employment and Training Administration Circuit Science, Inc., Including Workers Whose Unemployment Insurance... subject firm had their wages reported under a separated unemployment insurance (UI) tax account under the... workers whose unemployment insurance (UI) wages are reported through Circuit, Plymouth, Minnesota,...

  8. ESU Activity Report 2011

    ERIC Educational Resources Information Center

    Pall, Allan, Ed.; Ufert, Karina, Ed.; Slegers, Marianne, Ed.

    2011-01-01

    European Students' Union (ESU) has been representing students since 1982. In these, almost 30 years, ESU has been going from strength to strength as a European organisation. Each year has been crucial. This report brings to the fore its notable achievements and work done in 2011. The carousel of higher education reform on the national level was at…

  9. Dissemination Activities Report

    ERIC Educational Resources Information Center

    Barclay, Hanna; Batatia, Hudj; Bauters, Merja; Ben Ami, Zvi; Drachman, Raul; Flouris, Giorgos; Jadin, Tanja; Jalonen, Satu; Karlgren, Klas; Karpati, Andrea; Kotzinos, Dimitris; Lakkala, Minna; Lallimo, Jiri; Moen, Anne; Nygard, Kathrine; Paavola, Sami; Padiglia, Sheila; Scapolla, Marina; Sins, Patrick; Vasileva, Tania

    2008-01-01

    In the first 24 months of the project, KP-Lab members were highly dedicated to dissemination and were engaged in various dissemination activities that contributed to the prime objective of the KP-Lab dissemination efforts which is "to make the project widely known to a variety of prospective users and, at a later stage, to promote the…

  10. 77 FR 62265 - Long Elevator & Machine Company, Inc., Including Workers Whose Wages Were Reported Through Kone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ... Elevator & Machine Company, Inc., Including Workers Whose Wages Were Reported Through Kone, Inc., Riverton... workers of Long Elevator & Machine Company, Inc., including workers whose wages were reported through Kone, Inc., Riverton, Illinois (hereafter referred to as Long Elevator & Machine Company or the subject...

  11. 40 CFR 60.3051 - What information must I include in my annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 60.3046(b)(6) and (c) through (e) for the calendar year being reported. (h) If a performance test was... 40 Protection of Environment 6 2011-07-01 2011-07-01 false What information must I include in my... December 9, 2004 Model Rule-Recordkeeping and Reporting § 60.3051 What information must I include in...

  12. 30 CFR 585.701 - What must I include in my Facility Design Report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What must I include in my Facility Design Report? 585.701 Section 585.701 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... Facility Design, Fabrication, and Installation Reports § 585.701 What must I include in my Facility...

  13. 30 CFR 585.701 - What must I include in my Facility Design Report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What must I include in my Facility Design Report? 585.701 Section 585.701 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... Facility Design, Fabrication, and Installation Reports § 585.701 What must I include in my Facility...

  14. 30 CFR 585.701 - What must I include in my Facility Design Report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What must I include in my Facility Design Report? 585.701 Section 585.701 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE... Facility Design, Fabrication, and Installation Reports § 585.701 What must I include in my Facility...

  15. 30 CFR 285.701 - What must I include in my Facility Design Report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my Facility Design Report? 285.701 Section 285.701 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Design, Fabrication, and Installation Reports § 285.701 What must I include in my Facility Design...

  16. 40 CFR 60.2956 - What information must I include in my annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....2934(a) or (b), and did not conduct a performance test during the reporting period, you must state that... report? The annual report required under § 60.2955 must include the ten items listed in paragraphs (a) through (j) of this section. If you have a deviation from the operating limits or the emission...

  17. E-Division activities report

    SciTech Connect

    Barschall, H.H.

    1983-07-01

    This report describes some of the activities in E (Experimental Physics) Division during the past year. E-division carries out research and development in areas related to the missions of the Laboratory. Many of the activities are in pure and applied atomic and nuclear physics and in materials science. In addition, this report describes development work on accelerators and on instrumentation for plasma diagnostics, nitrogen exchange rates in tissue, and breakdown in gases by microwave pulses.

  18. E-Division activities report

    SciTech Connect

    Barschall, H.H.

    1981-07-01

    This report describes some of the activities in E (Experimental Physics) Division during the past year. E-Division carries out research and development in areas related to the missions of the Laboratory. Many of the activities are in pure and applied atomic and nuclear physics and in material science. In addition this report describes work on accelerators, microwaves, plasma diagnostics, determination of atmospheric oxygen and of nitrogen in tissue.

  19. 75 FR 20387 - Contech Castings, LLC, Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Contech Castings, LLC, Including Workers Whose Unemployment Insurance... subject firm had their wages reported under a separate unemployment insurance (UI) tax account under...

  20. 30 CFR 285.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Installation Report? 285.702 Section 285.702 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE... Facility Design, Fabrication, and Installation Reports § 285.702 What must I include in my Fabrication and... fabricated and installed in accordance with the design criteria identified in the Facility Design...

  1. 30 CFR 285.701 - What must I include in my Facility Design Report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I include in my Facility Design Report? 285.701 Section 285.701 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND... OUTER CONTINENTAL SHELF Facility Design, Fabrication, and Installation Reports § 285.701 What must...

  2. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... annual report required under § 60.2205 must include the ten items listed in paragraphs (a) through (j) of... the reporting period. (j) Documentation of periods when all qualified CISWI unit operators were... convenience of the user, the added and revised text is set forth as follows: § 60.2210 What information must...

  3. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Credit for market promotion activities, including paid... promotion activities, including paid advertising. (a) In order for a handler to receive credit for his/her...) Other market promotion activities. Credit-Back shall be granted for market promotion other than...

  4. 45 CFR 2540.300 - What must be included in annual State reports to the Corporation?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false What must be included in annual State reports to the Corporation? 2540.300 Section 2540.300 Public Welfare Regulations Relating to Public Welfare... Requirements for Recipients of Corporation Assistance § 2540.300 What must be included in annual State...

  5. 45 CFR 2540.300 - What must be included in annual State reports to the Corporation?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false What must be included in annual State reports to the Corporation? 2540.300 Section 2540.300 Public Welfare Regulations Relating to Public Welfare... Requirements for Recipients of Corporation Assistance § 2540.300 What must be included in annual State...

  6. 77 FR 44678 - Lawson Software, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Were Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Employment and Training Administration Lawson Software, Inc., Including Workers Whose Unemployment Insurance... Software Americas, Inc. and Infor, Inc., and including remote workers working from home throughout the... reporting to St. Paul, Minnesota who became totally or partially separated from employment on or after...

  7. System-Cost-Optimized Smart EVSE for Residential Application: Final Technical Report including Manufacturing Plan

    SciTech Connect

    Zhu, Charles

    2015-05-15

    In the 2nd quarter of 2012, a program was formally initiated at Delta Products to develop smart-grid-enabled Electric Vehicle Supply Equipment (EVSE) product for residential use. The project was funded in part by the U.S. Department of Energy (DOE), under award DE-OE0000590. Delta products was the prime contractor to DOE during the three year duration of the project. In addition to Delta Products, several additional supplier-partners were engaged in this research and development (R&D) program, including Detroit Edison DTE, Mercedes Benz Research and Development North America, and kVA. This report summarizes the program and describes the key research outcomes of the program. A technical history of the project activities is provided, which describes the key steps taken in the research and the findings made at successive stages in the multi-stage work. The evolution of an EVSE prototype system is described in detail, culminating in prototypes shipped to Department of Energy Laboratories for final qualification. After the program history is reviewed, the key attributes of the resulting EVSE are described in terms of functionality, performance, and cost. The results clearly demonstrate the ability of this EVSE to meet or exceed DOE's targets for this program, including: construction of a working product-intent prototype of a smart-grid-enabled EVSE, with suitable connectivity to grid management and home-energy management systems, revenue-grade metering, and related technical functions; and cost reduction of 50% or more compared to typical market priced EVSEs at the time of DOE's funding opportunity announcement (FOA), which was released in mid 2011. In addition to meeting all the program goals, the program was completed within the original budget and timeline established at the time of the award. The summary program budget and timeline, comparing plan versus actual values, is provided for reference, along with several supporting explanatory notes. Technical information

  8. Nuclear actin activates human transcription factor genes including the OCT4 gene.

    PubMed

    Yamazaki, Shota; Yamamoto, Koji; Tokunaga, Makio; Sakata-Sogawa, Kumiko; Harata, Masahiko

    2015-01-01

    RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.

  9. Reporters to monitor cellular MMP12 activity

    NASA Astrophysics Data System (ADS)

    Cobos-Correa, Amanda; Mall, Marcus A.; Schultz, Carsten

    2010-02-01

    Macrophage elastase, also called MMP12, belongs to a family of proteolytic enzymes whose best known physiological function is the remodeling of the extracellular matrix. Under certain pathological conditions, including inflammation, chronic overexpression of MMP12 has been observed and its elevated proteolytic activity has been suggested to be the cause of pulmonary emphysema. However, it was until recently impossible to monitor the activity of MMP12 under disease conditions, mainly due to a lack of detection methods. Recent development of new reporters for monitoring MMP12 activity in living cells, such as LaRee1, provided novel insights into the pathobiology of MMP12 in pulmonary inflammation.1 In the future, these reporters might contribute to improved diagnosis and in finding better treatments for chronic inflammatory lung diseases and emphysema. Our approach for visualizing MMP12 activity is based on peptidic, membrane-targeted FRET (Foerster Resonance Energy Transfer) reporters. Here we describe a set of new reporters containing different fluorophore pairs as well as modifications in the membrane-targeting lipid moiety. We studied the influence of these modifications on reporter performance and the reporter mobility on live cell membranes by FRAP (fluorescence recovery after photobleaching). Finally, we generated several new fluorescently labeled MMP inhibitors based on the peptidic reporter structures as prototypes for future tools to inhibit and monitor MMP activity at the same time.

  10. 41 CFR 102-37.75 - What should be included in a shortage report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.75 What should be... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What should be included in a shortage report? 102-37.75 Section 102-37.75 Public Contracts and Property Management...

  11. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 75-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Title Report § 102-75.125 What..., title, or interest in and to the real property (including copies of legal comments or...

  12. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 75-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Title Report § 102-75.125 What..., title, or interest in and to the real property (including copies of legal comments or...

  13. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 75-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Title Report § 102-75.125 What..., title, or interest in and to the real property (including copies of legal comments or...

  14. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 75-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Title Report § 102-75.125 What..., title, or interest in and to the real property (including copies of legal comments or...

  15. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 75-REAL PROPERTY DISPOSAL Utilization of Excess Real Property Title Report § 102-75.125 What..., title, or interest in and to the real property (including copies of legal comments or...

  16. Feasibility of including fugitive PM-10 emissions estimates in the EPA emissions trends report

    SciTech Connect

    Barnard, W.; Carlson, P.

    1990-09-01

    The report describes the results of Part 2 of a two part study. Part 2 was to evaluate the feasibility of developing regional emission trends for PM-10. Part 1 was to evaluate the feasibility of developing VOC emission trends, on a regional and temporal basis. These studies are part of the effort underway to improve the national emission trends. Part 1 is presented in a separate report. The categories evaluated for the feasibility of developing regional emissions estimates were: unpaved roads, paved roads, wind erosion, agricultural tilling, construction activities, feedlots, burning, landfills, mining and quarrying unpaved parking lots, unpaved airstrips and storage piles.

  17. 40 CFR 60.1875 - What must I include in my initial report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... block or 24-hour daily arithmetic average concentration of carbon monoxide emissions. (4) The 4-hour... emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed rates that you...

  18. 40 CFR 60.1885 - What must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... monitoring system (§ 60.1850(a)(1)). (d) For municipal waste combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates... municipal waste combustion units only, nitrogen oxides emissions. (3) Carbon monoxide emissions. (4)...

  19. 40 CFR 60.1875 - What must I include in my initial report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... block or 24-hour daily arithmetic average concentration of carbon monoxide emissions. (4) The 4-hour... emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed rates that you...

  20. 40 CFR 62.15340 - What must I include in the annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent dioxins/furans and mercury... emissions. (2) For Class I municipal waste combustion units only, nitrogen oxides emissions. (3)...

  1. 40 CFR 62.15340 - What must I include in the annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent dioxins/furans and mercury... emissions. (2) For Class I municipal waste combustion units only, nitrogen oxides emissions. (3)...

  2. 40 CFR 60.1875 - What must I include in my initial report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... block or 24-hour daily arithmetic average concentration of carbon monoxide emissions. (4) The 4-hour... emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed rates that you...

  3. 40 CFR 60.1410 - What must I include in my annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) For municipal waste combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent..., nitrogen oxides emissions. (3) Carbon monoxide emissions. (4) Load level of the municipal waste...

  4. 40 CFR 60.1875 - What must I include in my initial report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... block or 24-hour daily arithmetic average concentration of carbon monoxide emissions. (4) The 4-hour... emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed rates that you...

  5. 40 CFR 62.15340 - What must I include in the annual report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent dioxins/furans and mercury... emissions. (2) For Class I municipal waste combustion units only, nitrogen oxides emissions. (3)...

  6. Quadruple cancer including Bowen's disease after arsenic injections 40 years earlier: report of a case.

    PubMed

    Murata, K; Iwazawa, T; Takayama, T; Yamashita, K; Okagawa, K

    1994-01-01

    This report describes the successful treatment of quadruple cancer including Bowen's disease in a 71-year-old man who had been given injections of salvarsan, an arsenic compound, for syphilis more than 40 years earlier. Resection of a skin lesion on his chest subsequently confirmed a diagnosis of Bowen's disease, 3 years after which he was operated on for concurrent gastric cancer and sigmoid colon cancer. A fourth cancer was discovered on his left vocal cord 2 weeks after this operation; it was resected 2 years later. A discussion of multiple malignant neoplasms and the possible relationship between arsenic and cancer is presented following this case report.

  7. Report on 3 patients with 12p duplication including GRIN2B.

    PubMed

    Poirsier, Celine; Landais, Emilie; Bednarek, Nathalie; Nobecourt, Jean-Marie; Khoury, Maroun; Schmidt, Pascal; Morville, Patrice; Gruson, Nadine; Clomes, Sandrine; Michel, Nicole; Riot, Anita; Manjeongean, Christelle; Gaillard, Dominique; Doco-Fenzy, Martine

    2014-04-01

    The duplication of the short arm (p) of chromosome 12 is a rare chromosomal abnormality, and most reported cases result from malsegregation of a balanced parental translocation associated with other chromosomal imbalances. Of the reported cases, only 15 involve a pure and complete 12p duplication and only 10 involve a pure and partial duplication overlapping the 12p12.3p13.1 region, including a single instance of an inherited duplication in two related individuals. Here, we report three new patients with a pure 12p duplication, detected by conventional cytogenetic studies and characterized by array-comparative genomic hybridization (array-CGH) and fluorescence in situ hybridization (FISH). The first patient was a child carrying a de novo inverted duplication of the short arm of chromosome 12. His phenotype was similar to that of the "trisomy 12p syndrome", characterized by developmental delays and craniofacial abnormalities including a high forehead, a short nose with anteverted nostrils and an everted lower lip. The second and third patients were a mother and son with a direct 12p12.3p13.1 duplication, exhibiting a milder phenotype characterized by moderate developmental delays, dysmorphic facial features, behavioral problems and obesity. The present data, including the rarity of the familial cases, should contribute to our knowledge of the genotype/phenotype correlation in trisomy 12p patients.

  8. Improvements to the FATOLA computer program including added actively controlled landing gear subroutines

    NASA Technical Reports Server (NTRS)

    Mall, G. H.

    1983-01-01

    Modifications to a multi-degree-of-freedom flexible aircraft take-off and landing analysis (FATOLA) computer program, including a provision for actively controlled landing gears to expand the programs simulation capabilities, are presented. Supplemental instructions for preparation of data and for use of the modified program are included.

  9. The utility of including pathology reports in improving the computational identification of patients

    PubMed Central

    Chen, Wei; Huang, Yungui; Boyle, Brendan; Lin, Simon

    2016-01-01

    Background: Celiac disease (CD) is a common autoimmune disorder. Efficient identification of patients may improve chronic management of the disease. Prior studies have shown searching International Classification of Diseases-9 (ICD-9) codes alone is inaccurate for identifying patients with CD. In this study, we developed automated classification algorithms leveraging pathology reports and other clinical data in Electronic Health Records (EHRs) to refine the subset population preselected using ICD-9 code (579.0). Materials and Methods: EHRs were searched for established ICD-9 code (579.0) suggesting CD, based on which an initial identification of cases was obtained. In addition, laboratory results for tissue transglutaminse were extracted. Using natural language processing we analyzed pathology reports from upper endoscopy. Twelve machine learning classifiers using different combinations of variables related to ICD-9 CD status, laboratory result status, and pathology reports were experimented to find the best possible CD classifier. Ten-fold cross-validation was used to assess the results. Results: A total of 1498 patient records were used including 363 confirmed cases and 1135 false positive cases that served as controls. Logistic model based on both clinical and pathology report features produced the best results: Kappa of 0.78, F1 of 0.92, and area under the curve (AUC) of 0.94, whereas in contrast using ICD-9 only generated poor results: Kappa of 0.28, F1 of 0.75, and AUC of 0.63. Conclusion: Our automated classification system presented an efficient and reliable way to improve the performance of CD patient identification. PMID:27994938

  10. Solar attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Astrophysics Data System (ADS)

    Azor, Ruth

    1992-08-01

    In geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances, caused mainly by solar pressure. This work presents a roll/yaw control, which is obtained by the use of solar arrays and fixed flaps as actuators, with a horizon sensor for roll measurement. The design also includes an active nutation damping.

  11. Solar sail attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Technical Reports Server (NTRS)

    Azor, Ruth

    1992-01-01

    In geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances, caused mainly by solar radiation pressure. This work presents a roll/yaw control which is obtained by the use of solar arrays and fixed flaps as actuators, with a horizon sensor for roll measurement. The design also includes an active nutation damping.

  12. Implementation of the Project "Including Disabled Senior Citizens in Creative Activities in 2013-2015"

    ERIC Educational Resources Information Center

    Ploch, Leszek

    2015-01-01

    This paper made an attempt to indicate the findings of the author's research from the experiences of the implementation of the project "Including disabled senior citizens in creative activities in 2013-2015". The issues of disabled senior citizens have been an object of interest over the recent years though it still has not had a proper…

  13. Modifying Physical Activities to Include Individuals with Disabilities: A Systematic Approach

    ERIC Educational Resources Information Center

    Menear, Kristi S.; Davis, Tim

    2007-01-01

    Effectively including individuals with disabilities in a physical activity setting can often be a challenge due to constraints related to equipment, class size, curriculum, and the various ability levels of individuals with and without disabilities. However, there are ways the instructor can control the environment and tasks to meet the needs of…

  14. FY 2016 Status Report: Documentation of All CIRFT Data including Hydride Reorientation Tests (Draft M2)

    SciTech Connect

    Wang, Jy-An John; Wang, Hong; Jiang, Hao; Yan, Yong; Bevard, Bruce B.; Scaglione, John M.

    2016-09-04

    The first portion of this report provides a detailed description of fiscal year (FY) 2015 test result corrections and analysis updates based on FY 2016 updates to the Cyclic Integrated Reversible-Bending Fatigue Tester (CIRFT) program methodology, which is used to evaluate the vibration integrity of spent nuclear fuel (SNF) under normal conditions of transport (NCT). The CIRFT consists of a U-frame test setup and a real-time curvature measurement method. The three-component U-frame setup of the CIRFT has two rigid arms and linkages connecting to a universal testing machine. The curvature SNF rod bending is obtained through a three-point deflection measurement method. Three linear variable differential transformers (LVDTs) are clamped to the side connecting plates of the U-frame and used to capture deformation of the rod. The second portion of this report provides the latest CIRFT data, including data for the hydride reorientation test. The variations in fatigue life are provided in terms of moment, equivalent stress, curvature, and equivalent strain for the tested SNFs. The equivalent stress plot collapsed the data points from all of the SNF samples into a single zone. A detailed examination revealed that, at the same stress level, fatigue lives display a descending order as follows: H. B. Robinson Nuclear Power Station (HBR), LMK, and mixed uranium-plutonium oxide (MOX). Just looking at the strain, LMK fuel has a slightly longer fatigue life than HBR fuel, but the difference is subtle. The third portion of this report provides finite element analysis (FEA) dynamic deformation simulation of SNF assemblies . In a horizontal layout under NCT, the fuel assembly’s skeleton, which is formed by guide tubes and spacer grids, is the primary load bearing apparatus carrying and transferring vibration loads within an SNF assembly. These vibration loads include interaction forces between the SNF assembly and the canister basket walls. Therefore, the integrity of the guide

  15. 77 FR 38843 - Submission for OMB Review; Comment Request: Post-Award Reporting Requirements Including New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... National Research Service Award (NRSA) Individual Fellowship Progress Report for Continuation Support (PHS...) Individual Fellowship Progress Report for Continuation Support (PHS 416-9). Only one interim progress...

  16. Should Physical Activity Be Included in Nutrition Education? A Comparison of Nutrition Outcomes with and without In-Class Activities

    ERIC Educational Resources Information Center

    Palmer-Keenan, Debra M.; Corda, Kirsten

    2014-01-01

    Limited-resource adults' dietary intakes and nutrition behaviors improve as a result of Expanded Food and Nutrition Education Program (EFNEP)/Supplemental Nutrition Assistance Program Education (SNAP-Ed) participation; however, physical activity education is needed for improved health. The experimental study reported here assessed if spending time…

  17. Solar sail attitude control including active nutation damping in a fixed-momentum wheel satellite

    NASA Astrophysics Data System (ADS)

    Azor, Ruth

    1992-02-01

    In the geostationary cruise of a momentum biased satellite, it is necessary to stabilize the roll/yaw attitude due to disturbances caused by solar radiation pressure. This work presents a roll/yaw control system with a horizon sensor for roll measurement. Roll/yaw control is obtained by the use of solar arrays and fixed flaps as actuators. The design also includes an active nutation damping method.

  18. Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.

    PubMed

    Corton, J Christopher; Apte, Udayan; Anderson, Steven P; Limaye, Pallavi; Yoon, Lawrence; Latendresse, John; Dunn, Corrie; Everitt, Jeffrey I; Voss, Kenneth A; Swanson, Cynthia; Kimbrough, Carie; Wong, Jean S; Gill, Sarjeet S; Chandraratna, Roshantha A S; Kwak, Mi-Kyoung; Kensler, Thomas W; Stulnig, Thomas M; Steffensen, Knut R; Gustafsson, Jan-Ake; Mehendale, Harihara M

    2004-10-29

    The obesity epidemic in industrialized countries is associated with increases in cardiovascular disease (CVD) and certain types of cancer. In animal models, caloric restriction (CR) suppresses these diseases as well as chemical-induced tissue damage. These beneficial effects of CR overlap with those altered by agonists of nuclear receptors (NR) under control of the fasting-responsive transcriptional co-activator, peroxisome proliferator-activated co-activator 1alpha (PGC-1alpha). In a screen for compounds that mimic CR effects in the liver, we found statistically significant overlaps between the CR transcript profile in wild-type mice and the profiles altered by agonists of lipid-activated NR, including peroxisome proliferator-activated receptor alpha (PPARalpha), liver X receptor, and their obligate heterodimer partner, retinoid X receptor. The overlapping genes included those involved in CVD (lipid metabolism and inflammation) and cancer (cell fate). Based on this overlap, we hypothesized that some effects of CR are mediated by PPARalpha. As determined by transcript profiling, 19% of all gene expression changes in wild-type mice were dependent on PPARalpha, including Cyp4a10 and Cyp4a14, involved in fatty acid omega-oxidation, acute phase response genes, and epidermal growth factor receptor but not increases in PGC-1alpha. CR protected the livers of wild-type mice from damage induced by thioacetamide, a liver toxicant and hepatocarcinogen. CR protection was lost in PPARalpha-null mice due to inadequate tissue repair. These results demonstrate that PPARalpha mediates some of the effects of CR and indicate that a pharmacological approach to mimicking many of the beneficial effects of CR may be possible.

  19. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review.

    PubMed

    Ricketts, Marie-Louise; Moore, David D; Banz, William J; Mezei, Orsolya; Shay, Neil F

    2005-06-01

    Consumption of soy has been demonstrated to reduce circulating cholesterol levels, most notably reducing low-density lipoprotein (LDL) cholesterol levels in hypercholesterolemic individuals. The component or components that might be responsible for this effect is still a matter of debate or controversy among many researchers. Candidate agents include an activity of soy protein itself, bioactive peptides produced during the digestive process, or the soy isoflavones. Although soy intake may provide other health benefits including preventative or remediative effects on cancer, osteoporosis and symptoms of menopause, this review will focus on isoflavones as agents affecting lipid metabolism. Isoflavones were first discovered as a bioactive agent disrupting estrogen action in female sheep, thereby earning the often-used term 'phytoestrogens'. Subsequent work confirmed the ability of isoflavones to bind to estrogen receptors. Along with the cholesterol-lowering effect of soy intake, research that is more recent has pointed to a beneficial antidiabetic effect of soy intake, perhaps mediated by soy isoflavones. The two common categories of antidiabetic drugs acting on nuclear receptors known as peroxisome proliferator activated receptors (PPARs) are the fibrates and glitazones. We and others have recently asked the research question 'do the soy isoflavones have activities as either "phytofibrates" or "phytoglitazones"?' Such an activity should be able to be confirmed both in vivo and in vitro. In both the in vivo and in vitro cases, this action has indeed been confirmed. Further work suggests a possible action of isoflavones similar to the nonestrogenic ligands that bind the estrogen-related receptors (ERRs). Recently, these receptors have been demonstrated to contribute to lipolytic processes. Finally, evaluation of receptor activation studies suggests that thyroid receptor activation may provide additional clues explaining the metabolic action of isoflavones. The recent

  20. 32 CFR 37.880 - What requirements must I include for periodic reports on program and business status?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... reports on program and business status? 37.880 Section 37.880 National Defense Department of Defense... requirements must I include for periodic reports on program and business status? Your TIA must include either..., business status. You must require submission of the reports at least annually, and you may...

  1. 32 CFR 37.880 - What requirements must I include for periodic reports on program and business status?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reports on program and business status? 37.880 Section 37.880 National Defense Department of Defense... requirements must I include for periodic reports on program and business status? Your TIA must include either..., business status. You must require submission of the reports at least annually, and you may...

  2. Observing a fictitious stressful event: haematological changes, including circulating leukocyte activation.

    PubMed

    Mian, Rubina; Shelton-Rayner, Graham; Harkin, Brendan; Williams, Paul

    2003-03-01

    The aim of this study was to assess the effect of watching a psychological stressful event on the activation of leukocytes in healthy human volunteers. Blood samples were obtained from 32 healthy male and female subjects aged between 20 and 26 years before, during and after either watching an 83-minute horror film that none of the subjects had previously seen (The Texas Chainsaw Massacre, 1974) or by sitting quietly in a room (control group). Total differential cell counts, leukocyte activation as measured by the nitroblue tetrazolium (NBT) test, heart rate and blood pressure (BP) measurements were taken at defined time points. There were significant increases in peripheral circulating leukocytes, the number of activated circulating leukocytes, haemoglobin (Hb) concentration and haematocrit (Hct) in response to the stressor. These were accompanied by significant increases in heart rate, systolic and diastolic BP (P<0.05 from baseline). This is the first reported study on the effects of observing a psychologically stressful, albeit fictitious event on circulating leukocyte numbers and the state of leukocyte activation as determined by the nitrotetrazolium test.

  3. RDI's Wisdom Way Solar Village Final Report: Includes Utility Bill Analysis of Occupied Homes

    SciTech Connect

    Robb Aldrich, Steven Winter Associates

    2011-07-01

    In 2010, Rural Development, Inc. (RDI) completed construction of Wisdom Way Solar Village (WWSV), a community of ten duplexes (20 homes) in Greenfield, MA. RDI was committed to very low energy use from the beginning of the design process throughout construction. Key features include: 1. Careful site plan so that all homes have solar access (for active and passive); 2. Cellulose insulation providing R-40 walls, R-50 ceiling, and R-40 floors; 3. Triple-pane windows; 4. Airtight construction (~0.1 CFM50/ft2 enclosure area); 5. Solar water heating systems with tankless, gas, auxiliary heaters; 6. PV systems (2.8 or 3.4kWSTC); 7. 2-4 bedrooms, 1,100-1,700 ft2. The design heating loads in the homes were so small that each home is heated with a single, sealed-combustion, natural gas room heater. The cost savings from the simple HVAC systems made possible the tremendous investments in the homes' envelopes. The Consortium for Advanced Residential Buildings (CARB) monitored temperatures and comfort in several homes during the winter of 2009-2010. In the Spring of 2011, CARB obtained utility bill information from 13 occupied homes. Because of efficient lights, appliances, and conscientious home occupants, the energy generated by the solar electric systems exceeded the electric energy used in most homes. Most homes, in fact, had a net credit from the electric utility over the course of a year. On the natural gas side, total gas costs averaged $377 per year (for heating, water heating, cooking, and clothes drying). Total energy costs were even less - $337 per year, including all utility fees. The highest annual energy bill for any home evaluated was $458; the lowest was $171.

  4. [NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 5:] Summary report to phase 1 respondents including frequency distributions

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 1 of a four part study was undertaken to investigate the use of scientific and technical information (STI) by U.S. aerospace engineers and scientists. Specific attention was paid to institutional and sociometric variables and to the step-by-step process of information gathering used by the respondents. Data were collected by means of three self-administered mail-back questionnaires. The approximately 34,000 members of the American Institute of Aeronautics and Astronautics served as the study population. More than 65 percent of the randomly selected respondants returned the questionnaires in each of the three groups. Respondants relied more heavily on informal sources of information than formal sources and turned to librarians and other technical information specialists only when they did not obtain results via informal means or their own formal searches. The report includes frequency distributions for the questions.

  5. Could media reports include a standardized scale for quality of evidence?

    PubMed

    Braithwaite, R Scott

    2011-05-01

    While some media reports offer accurate interpretations of clinical research, other reports are misleading. The uneven accuracy of medical reporting may act in concert with its sheer volume to confuse the lay public about which health messages are most important and evidence-based. I outline one possible step towards a solution: medical journals can embed quality of evidence ratings in article summaries and create incentives for inclusion of these ratings in lay media reports.

  6. 30 CFR 285.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Installation Report? 285.702 Section 285.702 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... FACILITIES ON THE OUTER CONTINENTAL SHELF Facility Design, Fabrication, and Installation Reports § 285.702... Report must describe how your facilities will be fabricated and installed in accordance with the...

  7. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.

    PubMed

    Koo, Taeyoung; Lee, Jungjoon; Kim, Jin-Soo

    2015-06-01

    Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations.

  8. Active Matrix OLED Test Report

    NASA Technical Reports Server (NTRS)

    Salazar, George

    2013-01-01

    This report focuses on the limited environmental testing of the AMOLED display performed as an engineering evaluation by The NASA Johnson Space Center (JSC)-specifically. EMI. Thermal Vac, and radiation tests. The AMOLED display is an active-matrix Organic Light Emitting Diode (OLED) technology. The testing provided an initial understanding of the technology and its suitability for space applications. Relative to light emitting diode (LED) displays or liquid crystal displays (LCDs), AMOLED displays provide a superior viewing experience even though they are much lighter and smaller, produce higher contrast ratio and richer colors, and require less power to operate than LCDs. However, AMOLED technology has not been demonstrated in a space environment. Therefore, some risks with the technology must be addressed before they can be seriously considered for human spaceflight. The environmental tests provided preliminary performance data on the ability of the display technology to handle some of the simulated induced space/spacecraft environments that an AMOLED display will see during a spacecraft certification test program. This engineering evaluation is part of a Space Act Agreement (SM) between The NASA/JSC and Honeywell International (HI) as a collaborative effort to evaluate the potential use of AMOLED technology for future human spaceflight missions- both government-led and commercial. Under this SM, HI is responsible for doing optical performance evaluation, as well as temperature and touch screen studies. The NASA/JSC is responsible for performing environmental testing comprised of EMI, Thermal Vac, and radiation tests. Additionally, as part of the testing, limited optical data was acquired to assess performance as the display was subjected to the induced environments. The NASA will benefit from this engineering evaluation by understanding AMOLED suitability for future use in space as well as becoming a smarter buyer (or developer) of the technology. HI benefits

  9. Composting of soils/sediments and sludges containing toxic organics including high energy explosives. Final report

    SciTech Connect

    Doyle, R.C.; Kitchens, J.F.

    1993-07-01

    Laboratory and pilot-scale experimentation were conducted to evaluate composting as an on-site treatment technology to remediate soils contaminated with hazardous waste at DOE`s PANTEX Plant. Suspected contaminated sites within the PANTEX Plant were sampled and analyzed for explosives, other organics, and inorganic wastes. Soils in drainage ditches and playas at PANTEX Plant were found to be contaminated with low levels of explosives (including RDX, HMX, PETN and TATB). Additional sites previously used for solvent disposal were heavily contaminated with solvents and transformation products of the solvent, as well as explosives and by-products of explosives. Laboratory studies were conducted using {sup 14}C-labeled explosives and {sup 14}C-labeled diacetone alcohol contaminated soil loaded into horse manure/hay composts at three rates: 20, 30, and 40%(W/W). The composts were incubated for six weeks at approximately 60{degree}C with continuous aeration. All explosives degraded rapidly and were reduced to below detection limits within 3 weeks in the laboratory studies. {sup 14}C-degradates from {sup 14}C-RDX, {sup 14}C-HMX and {sup 14}C-TATB were largely limited to {sup 14}CO{sub 2} and unextracted residue in the compost. Volatile and non-volatile {sup 14}C-degradates were found to result from {sup 14}C-PETN breakdown, but these compounds were not identified. {sup 14}C-diacetone alcohol concentrations were significantly reduced during composting. However, most of the radioactivity was volatilized from the compost as non-{sup 14}CO{sub 2} degradates or as {sup 14}C-diacetone alcohol. Pilot scale composts loaded with explosives contaminated soil at 30% (W/W) with intermittent aeration were monitored over six weeks. Data from the pilot-scale study generally was in agreement with the laboratory studies. However, the {sup 14}C-labeled TATB degraded much faster than the unlabeled TATB. Some formulations of TATB may be more resistant to composting activity than others.

  10. Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity

    PubMed Central

    2013-01-01

    Background Ursodeoxycholic acid (UDCA) is used to treat primary biliary cirrhosis, intrahepatic cholestasis, and other cholestatic conditions. Although much has been learned about the molecular basis of the disease pathophysiology, our understanding of the effects of UDCA remains unclear. Possibly underlying its cytoprotective, anti-apoptotic, anti-oxidative effects, UDCA was reported to regulate the expression of TNFα and other inflammatory cytokines. However, it is not known if this effect involves also modulation of ADAM family of metalloproteinases, which are responsible for release of ectodomains of inflammatory cytokines from the cell surface. We hypothesized that UDCA modulates ADAM17 activity, resulting in amelioration of cholestasis in a murine model of bile duct ligation (BDL). Methods The effect of UDCA on ADAM17 activity was studied using the human liver hepatocellular carcinoma cell line HepG2. Untransfected cells or cells ectopically expressing human ADAM17 were cultured with or without UDCA and further activated using phorbol-12-myristate-13-acetate (PMA). The expression and release of ADAM17 substrates, TNFα, TGFα, and c-Met receptor (or its soluble form, sMet) were evaluated using ELISA and quantitative real-time (qRT) PCR. Immunoblotting analyses were conducted to evaluate expression and activation of ADAM17 as well as the level of ERK1/2 phosphorylation after UDCA treatment. The regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) by UDCA was studied using zymography and qRT-PCR. A mouse model of acute cholestasis was induced by common BDL technique, during which mice received daily orogastric gavage with either UDCA or vehicle only. Liver injury was quantified using alkaline phosphatase (ALP), relative liver weight, and confirmed by histological analysis. ADAM17 substrates in sera were assessed using a bead multiplex assay. Results UDCA decreases amount of shed TNFα, TGFα, and sMet in cell culture media and the phosphorylation of

  11. 76 FR 178 - Ocwen Loan Servicing, LLC; Including Workers Whose Wages Were Reported Under HomEQ Servicing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... Under HomEQ Servicing; North Highlands, CA; Ocwen Loan Servicing, LLC; Including Workers Whose Wages Were Reported Under HomEQ Servicing; Raleigh, NC; Amended Certification Regarding Eligibility To Apply..., including workers whose wages were reported under HomEQ Servicing, North Highland, California. The...

  12. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... required under § 60.2765 must include the ten items listed in paragraphs (a) through (j) of this section.... (j) Documentation of periods when all qualified CISWI unit operators were unavailable for more than 8... and revised text is set forth as follows: § 60.2770 What information must I include in my...

  13. Should singing activities be included in speech and voice therapy for prepubertal children?

    PubMed

    Rinta, Tiija; Welch, Graham F

    2008-01-01

    Customarily, speaking and singing have tended to be regarded as two completely separate sets of behaviors in clinical and educational settings. The treatment of speech and voice disorders has focused on the client's speaking ability, as this is perceived to be the main vocal behavior of concern. However, according to a broader voice-science perspective, given that the same vocal structure is used for speaking and singing, it may be possible to include singing in speech and voice therapy. In this article, a theoretical framework is proposed that indicates possible benefits from the inclusion of singing in such therapeutic settings. Based on a literature review, it is demonstrated theoretically why singing activities can potentially be exploited in the treatment of prepubertal children suffering from speech and voice disorders. Based on this theoretical framework, implications for further empirical research and practice are suggested.

  14. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How are IRR Program projects and activities included in a... Contracts and Agreements Under Isdeaa § 170.623 How are IRR Program projects and activities included in a self-governance agreement? To include an IRR Program project or activity in a self-governance...

  15. Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation.

    PubMed

    Fisher, Melanie C; Li, Yingcui; Seghatoleslami, M Reza; Dealy, Caroline N; Kosher, Robert A

    2006-01-01

    Bone morphogenetic proteins (BMPs) are involved in multiple aspects of limb development including regulation of cartilage differentiation. Several BMPs bind strongly to heparin, and heparan sulfate proteoglycans (HSPGs) at the cell surface or in the extracellular matrix have recently been implicated as modulators of BMP signaling in some developing systems. Here we have explored the role of HSPGs in regulating BMP activity during limb chondrogenesis by evaluating the effects of exogenous heparan sulfate (HS), heparitinase treatment, and overexpression of the HSPG syndecan-3 on the ability of BMP2 to modulate the chondrogenic differentiation of limb mesenchymal cells in micromass culture. Exogenous HS dramatically enhances the ability of BMP2 to stimulate chondrogenesis and cartilage specific gene expression, and reduces the concentration of BMP2 needed to stimulate chondrogenesis. Furthermore, HS stimulates BMP2-mediated phosphorylation of Smad1, Smad5, and Smad8, transcriptional mediators of BMP2 signaling, indicating that HS enhances the interaction of BMP2 with its receptors. Pretreatment of micromass cultures with heparitinase to degrade endogenous HSPGs also enhances the chondrogenic activity of BMP2, and reduces the concentration of BMP2 needed to promote chondrogenesis. Taken together these results indicate that exogenous HS or heparitinase enhance the chondrogenic activity of BMP2 by interfering with its interaction with endogenous HSPGs that would normally restrict its interaction with its receptors. Consistent with the possibility that HSPGs are negative modulators of BMP signaling during chondrogenesis, we have found that overexpression of syndecan-3, which is one of the major HSPGs normally expressed during chondrogenesis, greatly impairs the ability of BMP2 to promote cartilage differentiation. Furthermore, retroviral overexpression of syndecan-3 inhibits BMP2-mediated Smad phosphorylation in the regions of the cultures in which chondrogenesis is

  16. 77 FR 65582 - Quad Graphics, Inc., Including Workers Whose Wages Were Reported Under Quad Graphics Printing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... Quad Graphics Printing Corp. and Quad Logistics Services, Effingham, IL; Amended Certification... wages reported under Quad Graphics, Inc., Quad Graphics Printing Corp., and Quad Logistics Services. The... Graphics Printing Corp. and Quad Logistics Services (TA-W-73,441H), who became totally or...

  17. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... under § 60.2740(b)(6) and (c) through (e) for the calendar year being reported. (h) If a performance..., time, and duration that each CMS was inoperative, except for zero (low-level) and high-level checks. (3...-level), mid-level (if applicable), or high-level calibration drift exceeds two times the...

  18. Energy integrated farm, including a solar methane digestor and alcohol plant. Final progress report

    SciTech Connect

    Meier, O.

    1982-01-01

    This final progress report summarizes the authors success in running an alcohol still. The still was to produce over 20,000 gallons of alcohol per year, the waste hot water would be used to heat a methane digestion system and for domestic space and water heating. Many problems were encountered and solutions were noted.

  19. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and Compliance Times for Commercial and Industrial Solid Waste Incineration Units that Commenced... established pursuant to § 60.2675 or § 60.2680. (e) If no deviation from any emission limitation or operating... (c) through (e) for the calendar year being reported. (h) If a performance test was conducted...

  20. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Performance for Commercial and Industrial Solid Waste Incineration Units for Which Construction Is Commenced... § 60.2115. (e) If no deviation from any emission limitation or operating limit that applies to you has...) through (e) for the calendar year being reported. (h) If a performance test was conducted during...

  1. Multiple and various anaesthetics, ketamine included, in a young patient with familial dysautonomia, Case report.

    PubMed

    Dell'oste, C; Vincenti, E; Torre, G

    1996-03-01

    A case report is presented of a 16-year-old patient who had undergone 16 general anaesthetics by different anaesthesists and under various anaesthetic techniques for dental, endoscopic, orthopaedic and ophthalmic surgical procedures over a period of 14 years. Use of ketamine, especially in an ambulatory setting, was found more suitable in terms of cardiovascular stability, safety and patient preference.

  2. 76 FR 2712 - Ocwen Loan Servicing, LLC, Including Workers Whose Wages Were Reported Under Barclays Capital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Register on December 8, 2010 (75 FR 76488). The notice as amended on December 17, 2010 to include workers... January 3, 2011 (76 FR 178). At the request of the company, the Department reviewed the certification...

  3. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... concentration of carbon monoxide emissions. (4) The 4-hour block arithmetic average load level of your municipal... supporting calculations as specified in § 60.1370(a)(1) and (2). (g) If you choose to monitor carbon...

  4. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... concentration of carbon monoxide emissions. (4) The 4-hour block arithmetic average load level of your municipal... supporting calculations as specified in § 60.1370(a)(1) and (2). (g) If you choose to monitor carbon...

  5. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... concentration of carbon monoxide emissions. (4) The 4-hour block arithmetic average load level of your municipal... supporting calculations as specified in § 60.1370(a)(1) and (2). (g) If you choose to monitor carbon...

  6. 40 CFR 62.15330 - What must I include in the initial report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... emissions. (3) The 4-hour block or 24-hour daily arithmetic average concentration of carbon monoxide... supporting calculations as specified in § 62.15310(a)(1) and (2). (g) If you choose to monitor carbon...

  7. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... concentration of carbon monoxide emissions. (4) The 4-hour block arithmetic average load level of your municipal... supporting calculations as specified in § 60.1370(a)(1) and (2). (g) If you choose to monitor carbon...

  8. 40 CFR 62.15330 - What must I include in the initial report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... emissions. (3) The 4-hour block or 24-hour daily arithmetic average concentration of carbon monoxide... supporting calculations as specified in § 62.15310(a)(1) and (2). (g) If you choose to monitor carbon...

  9. 40 CFR 62.15330 - What must I include in the initial report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... emissions. (3) The 4-hour block or 24-hour daily arithmetic average concentration of carbon monoxide... supporting calculations as specified in § 62.15310(a)(1) and (2). (g) If you choose to monitor carbon...

  10. 40 CFR 62.15330 - What must I include in the initial report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... emissions. (3) The 4-hour block or 24-hour daily arithmetic average concentration of carbon monoxide... supporting calculations as specified in § 62.15310(a)(1) and (2). (g) If you choose to monitor carbon...

  11. 40 CFR 62.15330 - What must I include in the initial report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon feed... emissions. (3) The 4-hour block or 24-hour daily arithmetic average concentration of carbon monoxide... supporting calculations as specified in § 62.15310(a)(1) and (2). (g) If you choose to monitor carbon...

  12. President's report on continuing the acquisition of the Peacekeeper (MX) missile. (Includes the Executive Summary)

    SciTech Connect

    Not Available

    1985-03-01

    The report and Executive Summary on the Peacekeeper missile contains the President's assessment of the requirement for Peacekeeper and the anticipated impact of the continued procurement of Peacekeeper missiles, pursuant to the provisions of Public Law 98-525, Section 110 of October 19, 1984. After thorough analysis, the President has concluded that the continued production and deployment of Peacekeeper (M-X) missiles in existing Minuteman silos is required in order to maintain U.S. national security interests, is consistent with U.S. arms control policy, and enhances the prospects for global stability. As a result, the President seeks to remove Congressional restrictions on the Fiscal Year 1985 funds that were authorized and appropriated by the Congress for the Peacekeeper missile program. The report provides the President's reasons and furnishes additional information as required by the Congress.

  13. Suggestive value of predilection site and imaging features of pediatric brainstem ganglioglioma including a case report.

    PubMed

    Anqi, X; Zhenlin, L; Xin, H; Chao, Y

    2015-02-01

    Brainstem ganglioglioma is rarely reported. Due to its low incidence and atypical site, a brainstem ganglioglioma could easily be misdiagnosed as occurs with other pathological neoplasms radiologically. Here, we report an 8-year-old girl with a brainstem tumor confirmed as a ganglioglioma based on postoperative pathology results. We suggest that when a tumor located in the lower brainstem with benign radiological characteristics occurs in a child with a long-term history, the possibility of brainstem ganglioglioma should be considered in the preoperative diagnosis in addition to other low-grade neoplasms. Early stage diagnosis of brainstem ganglioglioma based on the clinical and imaging features is valuable for clinicians in order to perform effective treatment and achieve a good prognosis.

  14. 76 FR 10395 - First American Title Insurance Company, Including Workers Whose Wages Were Reported Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Professional Staffing and Remedy/ Select, Waterloo, IA; Amended Certification Regarding Eligibility To Apply..., including on-site leased workers from, Remedy/Select, Waterloo, Iowa. The workers supplied administrative... Staffing and Remedy/Select, Waterloo, Iowa (TA-W-73,900A), who became totally or partially separated...

  15. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false What must I include in my initial... parameters as recorded in accordance with § 60.1365(b). (1) The 24-hour daily geometric average concentration... concentration of nitrogen oxides emissions. (3) The 4-hour block or 24-hour daily arithmetic...

  16. Be BOLD: Encouraging Girls to Include Unstructured Bouts of Physical Activity into Daily Routines

    ERIC Educational Resources Information Center

    Hill, Kory; Williams, Gwynne M.

    2014-01-01

    Adolescent girls are less active than their male counterparts and physical activity levels tend to decline as one ages. One of the goals of concerned physical educators is to promote a physically active lifestyle and to teach skills and promote behaviors that will allow students to be active both in and out of school. This article presents a…

  17. Activities report of PTT Research

    NASA Astrophysics Data System (ADS)

    In the field of postal infrastructure research, activities were performed on postcode readers, radiolabels, and techniques of operations research and artificial intelligence. In the field of telecommunication, transportation, and information, research was made on multipurpose coding schemes, speech recognition, hypertext, a multimedia information server, security of electronic data interchange, document retrieval, improvement of the quality of user interfaces, domotics living support (techniques), and standardization of telecommunication prototcols. In the field of telecommunication infrastructure and provisions research, activities were performed on universal personal telecommunications, advanced broadband network technologies, coherent techniques, measurement of audio quality, near field facilities, local beam communication, local area networks, network security, coupling of broadband and narrowband integrated services digital networks, digital mapping, and standardization of protocols.

  18. Activities report in applied physics

    NASA Astrophysics Data System (ADS)

    Research concerning acoustics, heat, architecture, materials research, and (optical) instrumentation is presented; active noise control and acoustic path identification were investigated. Energy conservation, solar energy, and building physics activities were carried out. Ultraviolet absorbing glasses, glass fibers, sheet glass, and aluminium and silicon oxynitrides, were studied. Glass fiber based sensor and laser applications, and optical space-instrumentation are discussed. Signal processing, sensors, and integrated electronics applications were developed. Scale model experiments for flow induced noise and vibrations, caused by engines, ventilators, wind turbines, and propellers, were executed. A multispectral charge coupled device airborne scanner, with four modules (one for forward observations) is described. A ground radar, based on seismic exploration signal processing and used for the location of pipes, sewers and cables, was developed.

  19. Apollo experience report: Safety activities

    NASA Technical Reports Server (NTRS)

    Rice, C. N.

    1975-01-01

    A description is given of the flight safety experiences gained during the Apollo Program and safety, from the viewpoint of program management, engineering, mission planning, and ground test operations was discussed. Emphasis is placed on the methods used to identify the risks involved in flight and in certain ground test operations. In addition, there are discussions on the management and engineering activities used to eliminate or reduce these risks.

  20. Modelling of an activated primary settling tank including the fermentation process and VFA elutriation.

    PubMed

    Ribes, J; Ferrer, J; Bouzas, A; Seco, A

    2002-10-01

    A complete model of a primary settler including both sedimentation and biological processes is presented. It is a one-dimensional model based on the solids flux concept and the conservation of mass that uses the Takács model for the settling velocity, which is corrected by a compression function in the lower layers. The biological model is based on the ASM2 and enlarged with the fermentation model proposed by this research group. The settler was split in ten layers and the flux terms in the mass balance for each layer is obtained by means of the settling model. A pilot plant has been operated to study the primary sludge fermentation and volatile fatty acids (VFA) elutriation in a primary settler tank. The model has been tested with pilot plant experimental data with very good results. It has been able to simulate the VFA production in the settler and their elutriation with the influent wastewater for all the studied experiments. The developed model is easily applicable to secondary settlers and thickeners, also taking into account biological activity inside them.

  1. Measuring Outcomes in Adult Weight Loss Studies That Include Diet and Physical Activity: A Systematic Review

    PubMed Central

    Millstein, Rachel A.

    2014-01-01

    Background. Measuring success of obesity interventions is critical. Several methods measure weight loss outcomes but there is no consensus on best practices. This systematic review evaluates relevant outcomes (weight loss, BMI, % body fat, and fat mass) to determine which might be the best indicator(s) of success. Methods. Eligible articles described adult weight loss interventions that included diet and physical activity and a measure of weight or BMI change and body composition change. Results. 28 full-text articles met inclusion criteria. Subjects, settings, intervention lengths, and intensities varied. All studies measured body weight (−2.9 to −17.3 kg), 9 studies measured BMI (−1.1 to −5.1 kg/m2), 20 studies measured % body fat (−0.7 to −10.2%), and 22 studies measured fat mass (−0.9 to −14.9 kg). All studies found agreement between weight or BMI and body fat mass or body fat % decreases, though there were discrepancies in degree of significance between measures. Conclusions. Nearly all weight or BMI and body composition measures agreed. Since body fat is the most metabolically harmful tissue type, it may be a more meaningful measure of health change. Future studies should consider primarily measuring % body fat, rather than or in addition to weight or BMI. PMID:25525513

  2. St. Croix River Reconnaissance Report Including Stillwater, Minnesota and New Richmond, Wisconsin.

    DTIC Science & Technology

    1984-01-01

    was determined that the flood problems at the Lake St. Croix communities of Bayport; Lake St. Croix Beach; Afton ; Prescott; Chisago Chain of Lakes...problems at the Lake St. -,. I Croix communities of Bayport, Lake St. Croix Beach, Afton , and Prescott; Chisago Chain of Lakes; Upper and Lower Clam...not only in the St. Croix River basin but on the Mississippi River below *the mouth of the St. Croix River as well. This objective included preserving

  3. Coma blisters after poisoning caused by central nervous system depressants: case report including histopathological findings.

    PubMed

    Branco, Maira Migliari; Capitani, Eduardo Mello De; Cintra, Maria Letícia; Hyslop, Stephen; Carvalho, Adriana Camargo; Bucaretchi, Fabio

    2012-01-01

    Blister formation and eccrine sweat gland necrosis is a cutaneous manifestation associated with states of impaired consciousness, most frequently reported after overdoses of central nervous system depressants, particularly phenobarbital. The case of a 45-year-old woman who developed "coma blisters" at six distinct anatomic sites after confirmed (laboratory) phenobarbital poisoning, associated with other central nervous system depressants (clonazepam, promethazine, oxcarbazepine and quetiapine), is presented. A biopsy from the left thumb blister taken on day 4 revealed focal necrosis of the epidermis and necrosis of sweat gland epithelial cells; direct immunofluorescence was strongly positive for IgG in superficial blood vessel walls but negative for IgM, IgA, C3 and C1q. The patient was discharged on day 21 with no sequelae.

  4. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  5. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  6. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  7. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  8. Women convicted of a sexual offence, including child pornography production: two case reports.

    PubMed

    Prat, S; Bertsch, I; Chudzik, L; Réveillère, Ch

    2014-03-01

    All available studies addressing the clinical and legal aspects of child pornography have systematically concerned male abusers. The social lens through which women are viewed tends to play down their responsibility in the sexual abuse of children. Unlike men, women rarely abuse children outside the close or family circle. Furthermore, they have frequently been abused themselves in their childhood. To our knowledge, no cases of women charged with sex-related offences, including child pornography, have been described in the literature. The psychopathological characteristics of female sexual abusers and of the two women in our cases tend to suggest that the deliberate downloading of child pornography images by women is unusual, as their deviant behaviour is not related to paedophile sexual arousal It is hypothesized that the act enables women perpetrators to satisfy the sexual urges of their spouse. Sexual abuse by women exists, but the nature of the abuse appears to be specific to the gender of the perpetrator. We present two cases of women charged with sexual offences concerning minors, including the production of child pornography material.

  9. 43 CFR 404.50 - What information will be included in the feasibility report prepared by Reclamation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAM Feasibility Studies § 404.50 What information will be included in the feasibility report prepared... will be based on Reclamation's review of the feasibility study and its application of the criteria set... feasibility report prepared by Reclamation. 404.50 Section 404.50 Public Lands: Interior Regulations...

  10. Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology.

    PubMed

    Petersson, Fredrik; Lian, Derrick; Chau, Yuk Ping; Yan, Benedict

    2012-03-01

    We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The patient underwent an ipsilateral selective (levels I-IV) neck dissection which showed metastasis in 3 out of 36 lymph nodes (levels 1-3). Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months.

  11. NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 7:Summary report to phase 2 respondents including frequency distributions

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 2 of the four phase NASA/DoD Aerospace Knowledge Diffusion Research Project was undertaken to study the transfer of scientific and technical information (STI) from government to the aerospace industry and the role of librarians and technical information specialists in the transfer process. Data was collected through a self-administered mailback questionnaire. Libraries identified as holding substantial aerospace or aeronautical technical report collections were selected to receive the questionnaires. Within each library, the person responsible for the technical report was requested to answer the questionnaire. Questionnaires were returned from approx. 68 pct. of the libraries. The respondents indicated that scientists and engineer are not aware of the services available from libraries/technical information centers and that scientists and engineers also under-utilized their services. The respondents also indicated they should be more involved in the process.

  12. Needs assessment activity report: Fiscal year 1995

    SciTech Connect

    1995-09-01

    The Needs Assessment program has assessed the packaging requirements of many U.S. Department of Energy (DOE) sites. These assessments have involved site visits and meetings with personnel involved with transportation and packaging of hazardous materials. By September 1995, 24 DOE facilities had been visited, with 14 site visits occurring in fiscal year 1995. As a result, these sites have been informed of some of the packaging activities that DOE has sponsored and is sponsoring, have been apprised of the affects of upcoming changes to transportation regulations, have discussed their near-term packaging needs, and have shared unique packaging they have developed, which may be of use to other DOE facilities. Program successes include discovery of a need for a reusable Type A liquid sample packaging and its development within another DOE task and establishing communications pathways between DOE sites that have similar transportation and packaging needs. This report recommends that the Needs Assessment activity continue to pursue the strategy of visiting DOE sites to meet with their transportation and packaging personnel. These visits will ensure that DOE needs are met, communications pathways between DOE sites are established and cultivated, and redundant packaging development is identified. The site visits should be expanded to include meetings with the long-range and strategic planners at each site, and at the DOE-Headquarters level, to ensure that all future transportation and packaging needs are identified early enough to allow adequate transportation assessment and packaging development. This activity could become a permanent conduit for information and will ensure that all future DOE transportation and packaging needs are satisfied in a cost-effective, timely, and efficient manner.

  13. Low-rank coal research annual report, July 1, 1989--June 30, 1990 including quarterly report, April--June 1990

    SciTech Connect

    Not Available

    1990-11-01

    Research programs in the following areas are presented: control technology and coal preparation; advance research and technology development; combustion; liquefaction; and gasification. Sixteen projects are included. Selected items have been processed separately for inclusion in the Energy Science and Technology Database.

  14. The Otosclerosis Problem: including Reports of Two Cases Pathologically Examined (Dalby Memorial Lecture)

    PubMed Central

    Gray, Albert A.

    1934-01-01

    The essential causative factor of otosclerosis is a gradually increasing defect in the vasomotor mechanism which governs the nutrition of the structures of the organ of hearing as a whole. The axon reflexes are, of course, included in this vasomotor mechanism, and the stimulus which excites the vasomotor mechanism is sound and sound alone. Consequently the vestibular apparatus and the semicircular canals are unaffected in otosclerosis. There is no evidence whatever of any defect in any of the endocrine glands or their secretions in otosclerosis. Neither is there any evidence of any defect in the bone metabolism of the body. On the contrary the subjects of otosclerosis are, apart from their deafness, perfectly normal individuals with ordinary average health. The deafness of otosclerosis bears very little relationship to the extent of the disease in the bone. The deafness may be very severe when the stapes is hardly fixed at all. The severity of the tinnitus bears no relationship at all to the extent of the disease in the bone. The extent of the change in the bone bears very little relationship to the duration of the disease. The extent of the changes in the bone appears to depend upon the age of onset of the disease. The earlier in life that the otosclerosis begins, the more extensive will the bone lesion become. The deafness of otosclerosis is to a large extent functional, and is the result of the insufficient supply of blood to all the nerve-structures concerned in the perception of sound. The preponderance of women as subjects of otosclerosis is the result of the greater instability of their vasomotor system and the more frequent disturbances to which it is exposed. The changes in the bone show a remarkable bilateral symmetry even to minute details. This symmetrical distribution is readily explained by the writer's view of the causative factor of otosclerosis. The vasomotor nerves governing the nutrition of the organ of hearing are anatomically symmetrical like

  15. Report on observational activity in (summer) 2015

    NASA Astrophysics Data System (ADS)

    Zejda, M.

    2016-03-01

    A short report on the author's observational activity in 2015 and the last 20 years is given. In total this means almost 900 nights, about a half million of CCD frames and thousands of photometric measurements.

  16. Acanthocytosis, retinitis pigmentosa, and pallidal degeneration: a report of three patients, including the second reported case with hypoprebetalipoproteinemia (HARP syndrome).

    PubMed

    Orrell, R W; Amrolia, P J; Heald, A; Cleland, P G; Owen, J S; Morgan-Hughes, J A; Harding, A E; Marsden, C D

    1995-03-01

    We describe an example of a variant of Hallervorden-Spatz disease, characterized by hypoprebeta-lipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP syndrome), in an 18-year-old woman who presented with longstanding intellectual subnormality, night blindness, and a 2-year history of orobuccolingual dystonia causing dysarthria and dysphagia. Investigation showed acanthocytosis and hypoprebetalipoproteinemia, and electroretinograms were typical of tapetoretinal degeneration. T2-weighted MRI showed decreased signal intensity in the pallidal nuclei with central hyperintensity, constituting the "eye-of-the-tiger" sign. The patient's sister and mother have a similar lipid disorder but no retinal or neurologic disease. We also report two patients with clinical and radiologic features similar to those of the patient with HARP syndrome but who had normal lipid studies. These various combinations of components of HARP syndrome may be caused by several distinct genetic diseases or may represent variable manifestations of a contiguous gene defect.

  17. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Sokolik, I. N.; Nenes, A.

    2008-09-01

    Dust and black carbon aerosol have long been known to have potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of such particles, and ignore interactions of the insoluble fraction with water vapor (even if known to be hydrophilic). To address this gap, we develop a new parameterization framework that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable) particles mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler Theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frankel-Halsey-Hill (FHH) adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory, and i) find combinations of the adsorption parameters AFHH, BFHH for which activation into cloud droplets is not possible, and, ii) express activation properties (critical supersaturation) that follow a simple power law with respect to dry particle diameter. Parameterization formulations are developed for sectional and lognormal aerosol size distribution functions. The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2 ~0.98.

  18. Field Operations Program Activities Status Report

    SciTech Connect

    J. E. Francfort; D. V. O'Hara; L. A. Slezak

    1999-05-01

    The Field Operations Program is an electric vehicle testing and evaluation program sponsored by US Department of Energy and managed by the Idaho National Engineering and Environmental Laboratory. The Program's goals are to evaluate electric vehicles in real-world applications and environments, support electric vehicle technology advancement, develop infrastructure elements necessary to support significant electric vehicle use, support increased use of electric vehicles in federal fleets, and increase overall awareness and acceptance of electric vehicles. This report covers Program activities from fiscal year 1997 through mid-fiscal year 1999. The Field Operations Program succeeded the Site Operator Program, which ended in September 1996. Electric vehicle testing conducted by the Program includes baseline performance testing (EV America testing), accelerated reliability (life-cycle) testing, and fleet testing. The baseline performance parameters include accelerations, braking, range, energy efficiency, and charging time. The Program collects accelerated reliability and fleet operations data on electric vehicles operated by the Program's Qualified Vehicle Testing (QVT) partners. The Program's QVT partners have over 3 million miles of electric vehicle operating experience.

  19. Diffractive laser beam homogenizer including a photo-active material and method of fabricating the same

    SciTech Connect

    Bayramian, Andy J; Ebbers, Christopher A; Chen, Diana C

    2014-05-20

    A method of manufacturing a plurality of diffractive optical elements includes providing a partially transmissive slide, providing a first piece of PTR glass, and directing first UV radiation through the partially transmissive slide to impinge on the first piece of PTR glass. The method also includes exposing predetermined portions of the first piece of PTR glass to the first UV radiation and thermally treating the exposed first piece of PTR glass. The method further includes providing a second piece of PTR glass and directing second UV radiation through the thermally treated first piece of PTR glass to impinge on the second piece of PTR glass. The method additionally includes exposing predetermined portions of the second piece of PTR glass to the second UV radiation, thermally treating the exposed second piece of PTR glass, and repeating providing and processing of the second piece of PTR glass using additional pieces of PTR glass.

  20. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... communication network), or portions of a web-site that target the farming or grower trade. (iii) For any... complementary product(s), or a handler selling multiple complementary products, including other nuts, with...

  1. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... communication network), or portions of a web-site that target the farming or grower trade. (iii) For any... complementary product(s), or a handler selling multiple complementary products, including other nuts, with...

  2. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... communication network), or portions of a web-site that target the farming or grower trade. (iii) For any... complementary product(s), or a handler selling multiple complementary products, including other nuts, with...

  3. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How are IRR Program projects and activities included in a self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  4. Electrode including porous particles with embedded active material for use in a secondary electrochemical cell

    DOEpatents

    Vissers, Donald R.; Nelson, Paul A.; Kaun, Thomas D.; Tomczuk, Zygmunt

    1978-04-25

    Particles of carbonaceous matrices containing embedded electrode active material are prepared for vibratory loading within a porous electrically conductive substrate. In preparing the particles, active materials such as metal chalcogenides, solid alloys of alkali or alkaline earth metals along with other metals and their oxides in powdered or particulate form are blended with a thermosetting resin and particles of a volatile to form a paste mixture. The paste is heated to a temperature at which the volatile transforms into vapor to impart porosity at about the same time as the resin begins to cure into a rigid, solid structure. The solid structure is then comminuted into porous, carbonaceous particles with the embedded active material.

  5. In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.

    PubMed

    Fujisaki, Ryuichi; Kamei, Kiyoko; Yamamura, Mariko; Nishiya, Hajime; Inouye, Shigeharu; Takahashi, Miki; Abe, Shigeru

    2012-03-01

    Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values.

  6. Parameterization of cloud droplet formation for global and regional models: including adsorption activation from insoluble CCN

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Sokolik, I. N.; Nenes, A.

    2009-04-01

    Dust and black carbon aerosol have long been known to exert potentially important and diverse impacts on cloud droplet formation. Most studies to date focus on the soluble fraction of these particles, and overlook interactions of the insoluble fraction with water vapor (even if known to be hydrophilic). To address this gap, we developed a new parameterization that considers cloud droplet formation within an ascending air parcel containing insoluble (but wettable) particles externally mixed with aerosol containing an appreciable soluble fraction. Activation of particles with a soluble fraction is described through well-established Köhler theory, while the activation of hydrophilic insoluble particles is treated by "adsorption-activation" theory. In the latter, water vapor is adsorbed onto insoluble particles, the activity of which is described by a multilayer Frenkel-Halsey-Hill (FHH) adsorption isotherm modified to account for particle curvature. We further develop FHH activation theory to i) find combinations of the adsorption parameters AFHH, BFHH which yield atmospherically-relevant behavior, and, ii) express activation properties (critical supersaturation) that follow a simple power law with respect to dry particle diameter. The new parameterization is tested by comparing the parameterized cloud droplet number concentration against predictions with a detailed numerical cloud model, considering a wide range of particle populations, cloud updraft conditions, water vapor condensation coefficient and FHH adsorption isotherm characteristics. The agreement between parameterization and parcel model is excellent, with an average error of 10% and R2~0.98. A preliminary sensitivity study suggests that the sublinear response of droplet number to Köhler particle concentration is not as strong for FHH particles.

  7. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities and Bibliography.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population concerns. Designed to educate general college audiences, it is also intended for use as a preservice course for teachers. In addition, the course can be modified for high school students. The course…

  8. Beyond Right or Wrong: Challenges of Including Creative Design Activities in the Classroom

    ERIC Educational Resources Information Center

    Brennan, Karen

    2015-01-01

    In this article, we explore challenges encountered by K-12 educators in establishing classroom cultures that support creative learning activities with the Scratch programming language. Providing opportunities for students to understand and to build capacities for creative work was described by many of the teachers that we interviewed as a central…

  9. Sixty Minutes of Physical Activity per Day Included within Preschool Academic Lessons Improves Early Literacy

    ERIC Educational Resources Information Center

    Kirk, Stacie M.; Kirk, Erik P.

    2016-01-01

    Background: The effects of increases in physical activity (PA) on early literacy skills in preschool children are not known. Methods: Fifty-four African-American preschool children from a low socioeconomic urban Head Start participated over 8 months. A 2-group, quasi-experimental design was used with one preschool site participating in the PA…

  10. Using assistive technology adaptations to include students with learning disabilities in cooperative learning activities.

    PubMed

    Bryant, D P; Bryant, B R

    1998-01-01

    Cooperative learning (CL) is a common instructional arrangement that is used by classroom teachers to foster academic achievement and social acceptance of students with and without learning disabilities. Cooperative learning is appealing to classroom teachers because it can provide an opportunity for more instruction and feedback by peers than can be provided by teachers to individual students who require extra assistance. Recent studies suggest that students with LD may need adaptations during cooperative learning activities. The use of assistive technology adaptations may be necessary to help some students with LD compensate for their specific learning difficulties so that they can engage more readily in cooperative learning activities. A process for integrating technology adaptations into cooperative learning activities is discussed in terms of three components: selecting adaptations, monitoring the use of the adaptations during cooperative learning activities, and evaluating the adaptations' effectiveness. The article concludes with comments regarding barriers to and support systems for technology integration, technology and effective instructional practices, and the need to consider technology adaptations for students who have learning disabilities.

  11. Physical Activity Programs in Higher Education: Modifying Net/Wall Games to Include Individuals with Disabilities

    ERIC Educational Resources Information Center

    Braga, Luciana; Tracy, Julia F.; Taliaferro, Andrea R.

    2015-01-01

    The growing number of students with disabilities in higher education settings has presented challenges for instructors with regards to appropriate inclusion. Concerning physical activity courses in higher education, instructors may not have the knowledge or resources to make modifications and accommodations that will ultimately result in…

  12. An Updated Review of Interventions that Include Promotion of Physical Activity for Adult Men.

    PubMed

    Bottorff, Joan L; Seaton, Cherisse L; Johnson, Steve T; Caperchione, Cristina M; Oliffe, John L; More, Kimberly; Jaffer-Hirji, Haleema; Tillotson, Sherri M

    2015-06-01

    The marked disparity in life expectancy between men and women suggests men are a vulnerable group requiring targeted health promotion programs. As such, there is an increasing need for health promotion strategies that effectively engage men with their health and/or illness management. Programs that promote physical activity could significantly improve the health of men. Although George et al. (Sports Med 42(3):281, 30) reviewed physical activity programs involving adult males published between 1990 and 2010, developments in men's health have prompted the emergence of new sex- and gender-specific approaches targeting men. The purpose of this review was to: (1) extend and update the review undertaken by George et al. (Sports Med 42(3):281, 30) concerning the effectiveness of physical activity programs in males, and (2) evaluate the integration of gender-specific influences in the content, design, and delivery of men's health promotion programs. A search of MEDLINE, CINAHL, ScienceDirect, Web of Science, PsycINFO, the Cochrane Library, and the SPORTDiscus databases for articles published between January 2010 and August 2014 was conducted. In total, 35 studies, involving evaluations of 31 programs, were identified. Findings revealed that a variety of techniques and modes of delivery could effectively promote physical activity among men. Though the majority of programs were offered exclusively to men, 12 programs explicitly integrated gender-related influences in male-specific programs in ways that recognized men's interests and preferences. Innovations in male-only programs that focus on masculine ideals and gender influences to engage men in increasing their physical activity hold potential for informing strategies to promote other areas of men's health.

  13. Space Resources for Teachers: Biology, Including Suggestions for Classroom Activities and Laboratory Experiments.

    ERIC Educational Resources Information Center

    Lee, Tom E.; And Others

    This compilation of resource units concerns the latest developments in space biology. Some of the topics included are oxygen consumption, temperature, radiation, rhythms, weightlessness, acceleration and vibration stress, toxicity, and sensory and perceptual problems. Many of the topics are interdisciplinary and relate biology, physiology,…

  14. A spatial model of cellular molecular trafficking including active transport along microtubules.

    PubMed

    Cangiani, A; Natalini, R

    2010-12-21

    We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.

  15. 41 CFR 102-192.90 - What must we include in our annual mail management report to GSA?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What must we include in our annual mail management report to GSA? 102-192.90 Section 102-192.90 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT...

  16. Evaluation of the HIV/AIDS Education Program/Including Condom Availability, 1990-1992. OREA Report.

    ERIC Educational Resources Information Center

    Simkin, Linda; And Others

    The number of adolescents with AIDS and the number of young adults diagnosed with AIDS who were infected with HIV during adolescence continues to grow at alarming rates. This report evaluates a program that included staff development, mandated HIV/AIDS education for children in kindergarten through grade 12, and a peer leadership component that…

  17. 32 CFR 37.880 - What requirements must I include for periodic reports on program and business status?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false What requirements must I include for periodic reports on program and business status? 37.880 Section 37.880 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT...

  18. A Methodology for Post Operational Clean Out of a Highly Active Facility Including Solids Behaviour - 12386

    SciTech Connect

    Edmondson, Michael J.; Ward, Tracy R.; Maxwell, Lisa J.

    2012-07-01

    The Highly Active Liquor Evaporation and Storage (HALES) plant at Sellafield handles acidic fission product containing liquor with typical activities of the order of 18x10{sup 9} Bq/ml. A strategy experimental feedback approach has been used to establish a wash regime for the Post Operational Clean Out (POCO) of the oldest storage tanks for this liquor. Two different wash reagents have been identified as being potentially suitable for removal of acid insoluble fission product precipitates. Ammonium carbamate and sodium carbonate yield similar products during the proposed wash cycle. The proposed wash reagents provide dissolution of caesium phosphomolybdate (CPM) and zirconium molybdate (ZM) solid phases but yields a fine, mobile precipitate of metal carbonates from the Highly Active Liquor (HAL) supernate. Addition of nitric acid to the wash effluent can cause CPM to precipitate where there is sufficient caesium and phosphorous available. Where they are not present (from ZM dissolution) the nitric acid addition initially produces a nitrate precipitate which then re-dissolves, along with the metal carbonates, to give a solid-free solution. The different behaviour of the two solids during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing the rheology of ZM sediments through doping with tellurium or particular organic acids. Two different wash reagents have been identified as being potentially suitable for the POCO of HALES Oldside HASTs. AC and SC both yield similar products during the proposed wash cycle. However, the different behaviour of the two principle HAL solids, CPM and ZM, during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing its rheology through doping with tellurium or certain

  19. Steady-state analysis of activated sludge processes with a settler model including sludge compression.

    PubMed

    Diehl, S; Zambrano, J; Carlsson, B

    2016-01-01

    A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration.

  20. Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

    SciTech Connect

    Michael Kruzic

    2007-09-01

    Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolition (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.

  1. LIPID PEROXIDATION GENERATES BIOLOGICALLY ACTIVE PHOSPHOLIPIDS INCLUDING OXIDATIVELY N-MODIFIED PHOSPHOLIPIDS

    PubMed Central

    Davies, Sean S.; Guo, Lilu

    2014-01-01

    Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease. PMID:24704586

  2. [Development of asymmetric synthesis of optically active compounds including fluoroorganic molecules].

    PubMed

    Iseki, K

    1999-11-01

    The synthesis of chiral fluorinated molecules is important in the biological and medicinal chemistry fields in view of the influence of fluorine's unique properties on biological activity. In recent years, we have studied asymmetric synthesis focussing on such optically active compounds. This review describes 1) diastereoselective trifluoromethylation of chiral N-acyloxazolidinones, 2) catalytic enantioselective aldol reactions of fluorine-substituted ketene silyl acetals, and 3) catalytic enantioselective allylation of aldehydes mediated by chiral Lewis bases. The trifluoromethylation of lithium enolates of N-acyloxazolidinones with iodotrifluoromethane is mediated by triethylborane to give the corresponding trifluoromethylated products with up to 86% diastereomeric excess. The stereoselective reaction is considered to proceed through the attack of the trifluoromethyl radical on the less hindered face of the lithium imide. Difluoroketene and bromofluoroketene trimethylsilyl ethyl acetals react with various aldehydes in the presence of chiral Lewis acids to afford the corresponding desired aldols with up to 99% enantiomeric excess (ee). It is noteworthy that the aldol reactions of the fluorine-substituted acetals at -78 degrees C and at higher temperatures (-45 or -20 degrees C) provide the (+)- and (-)-aldols, respectively, with excellent-to-good enantioselectivity. Chiral phosphoramides newly prepared from (S)-proline were found to catalyze the allylation and crotylation of aromatic aldehydes with allylic trichlorosilanes in good enantioselective yields (up to 90% ee). (S,S)-Bis(alpha-methylbenzyl)formamide developed as an efficient catalyst for the allylation and crotylation of aliphatic aldehydes mediates the enantioselective addition with the assistance of hexamethylphosphoramide (HMPA) to afford the corresponding homoallylic alcohols in up to 98% ee.

  3. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon... carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5) Temperature of...

  4. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon... carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5) Temperature of...

  5. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon... carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5) Temperature of...

  6. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon... carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5) Temperature of...

  7. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon... carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5) Temperature of...

  8. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon feed rate (calculated from the carbon injection... only, concentration of nitrogen oxides emissions. (3) Concentration of carbon monoxide emissions....

  9. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon feed rate (calculated from the carbon injection... only, concentration of nitrogen oxides emissions. (3) Concentration of carbon monoxide emissions....

  10. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon feed rate (calculated from the carbon injection... only, concentration of nitrogen oxides emissions. (3) Concentration of carbon monoxide emissions....

  11. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon feed rate (calculated from the carbon injection... only, concentration of nitrogen oxides emissions. (3) Concentration of carbon monoxide emissions....

  12. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8-hour block average carbon feed rate (calculated from the carbon injection... only, concentration of nitrogen oxides emissions. (3) Concentration of carbon monoxide emissions....

  13. Ozone control of biological activity during Earth's history, including the KT catastrophe

    NASA Technical Reports Server (NTRS)

    Sheldon, W. R.

    1994-01-01

    There have been brief periods since the beginning of the Cambrian some 600 m.y. ago when mass extinctions destroyed a significant fraction of living species. The most widely studied of these events is the catastrophe at the KT boundary that ended the long dominance of the dinosaurs. In addition to mass extinctions, there is another profound discontinuity in the history of Earth's biota, the explosion of life at the end of the Precambrian era which is an episode that is not explained well at all. For some 3 b.y. before the Cambrian, life had been present on Earth, but maintained a low level of activity which is an aspect of the biota that is puzzling, especially during the last two-thirds of that period. During the last 2 b.y. before the Cambrian, conditions at the Earth's surface were suitable for a burgeoning of the biota, according to most criteria: the oceans neither boiled nor were fozen solid during this time, and the atmosphere contained sufficient O for the development of animals. The purpose of this paper is to suggest that mass extinctions and the lackluster behavior of the Precambrian biota share a common cause: an inadequate amount of ozone in the atmosphere.

  14. Design of a high-lift experiment in water including active flow control

    NASA Astrophysics Data System (ADS)

    Beutel, T.; Sattler, S.; El Sayed, Y.; Schwerter, M.; Zander, M.; Büttgenbach, S.; Leester-Schädel, M.; Radespiel, R.; Sinapius, M.; Wierach, P.

    2014-07-01

    This paper describes the structural design of an active flow-control experiment. The aim of the experiment is to investigate the increase in efficiency of an internally blown Coanda flap using unsteady blowing. The system uses tailor-made microelectromechanical (MEMS) pressure sensors to determine the state of the oncoming flow and an actuated lip to regulate the mass flow and velocity of a stream near a wall over the internally blown flap. Sensors and actuators are integrated into a highly loaded system that is extremely compact. The sensors are connected to a bus system that feeds the data into a real-time control system. The piezoelectric actuators using the d 33 effect at a comparable low voltage of 120 V are integrated into a lip that controls the blowout slot height. The system is designed for closed-loop control that efficiently avoids flow separation on the Coanda flap. The setup is designed for water-tunnel experiments in order to reduce the free-stream velocity and the system’s control frequency by a factor of 10 compared with that in air. This paper outlines the function and verification of the system’s main components and their development.

  15. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase

    PubMed Central

    Sahonero-Canavesi, Diana X.; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M.; Geiger, Otto

    2016-01-01

    Summary Phospholipids are well known for their membrane forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth. PMID:25711932

  16. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase.

    PubMed

    Sahonero-Canavesi, Diana X; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M; Geiger, Otto

    2015-09-01

    Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth.

  17. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... creation and economic development activities? (a) A Tribe may conduct job market assessments within its NEW Program. These might include the following: (1) Consultation with the Tribe's economic development...

  18. Physics Division activities report, 1986--1987

    SciTech Connect

    Not Available

    1987-01-01

    This report summarizes the research activities of the Physics Division for the years 1986 and 1987. Areas of research discussed in this paper are: research on e/sup +/e/sup /minus// interactions; research on p/bar p/ interactions; experiment at TRIUMF; double beta decay; high energy astrophysics; interdisciplinary research; and advanced technology development and the SSC.

  19. Annual waste reduction activities report. Issue 1

    SciTech Connect

    1991-03-18

    This report discusses the waste minimization activities for the Pinellas Plant. The Pinellas Plant deals with low-level radioactive wastes, solvents, scrap metals and various other hazardous materials. This program has realized cost savings through recycling and reuse of materials.

  20. 14 CFR 440.11 - Duration of coverage for licensed launch, including suborbital launch, or permitted activities...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Duration of coverage for licensed launch, including suborbital launch, or permitted activities; modifications. 440.11 Section 440.11 Aeronautics and... Duration of coverage for licensed launch, including suborbital launch, or permitted...

  1. Energy and environmental research emphasizing low-rank coal: Task 3.4 -- Hot-gas cleaning. Topical report (includes semiannual report for January--June 1995)

    SciTech Connect

    Weber, G.F.; Swanson, M.L.

    1995-06-01

    This report summarizes the accomplishments of three subtasks completed in support of the current and future hot-gas cleanup activities at the Energy and Environmental Research Center (EERC). The overall objective of the EERC hot-gas cleanup task is to develop reliable methods to remove particulate matter from high-temperature, high-pressure gas streams produced from coal combustion and/or gasification. Near-term task objectives include (1) design, fabrication, and assembly of a high-temperature, high-pressure bench-scale filter vessel; (2) design, fabrication, and assembly of a high-temperature, high-pressure sampling train; and (3) the preliminary design of a pilot-scale high-temperature, high-pressure filter vessel and support systems. Bench-scale hot-gas filter research will be performed with the pressurized fluid-bed reactor (PFBR) or the continuous fluid-bed reactor (CFBR) and a hot-gas filter vessel. The objectives of future work with the bench-scale system will be to determine particulate and vapor-phase alkali degradation of candidate ceramic filter structures as well as filter performance relative to particulate collection efficiency, differential pressure, and filter cleanability. Construction of the high-temperature, high-pressure sampling system was intended to support bench- and pilot-scale activities with respect to conventional particulate sampling (total mass and particle-size distribution) and hazardous air pollutant (HAP) sampling. Finally, pilot-scale tests will be performed to evaluate filter performance and determine alkali corrosion of ceramic materials with a hot-gas filter vessel attached to the EERC Transport Reactor Development Unit (TRDU).

  2. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Vette, J. I. (Editor); Vostreys, R. W. (Editor)

    1977-01-01

    Information concerning active and planned spacecraft and experiments is reported. The information includes a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and funding of individual countries as well as cooperative arrangements among different countries.

  3. Section on Cataloguing: Report of the Activities, 2000-2001.

    ERIC Educational Resources Information Center

    Witt, Maria

    This paper reports on the activities of the IFLA (International Federation of Library Associations and Institutions) Section on Cataloging for 2000-2001. The first part discusses the interest in cataloging and its harmonization at the international level that is shared by libraries throughout the world, including the section's work on development…

  4. 21 CFR 803.33 - If I am a user facility, what must I include when I submit an annual report?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Reporting Requirements § 803.33 If I am a user facility, what must I include when I submit an annual report... during the annual reporting period including: (i) Report number; (ii) Name and address of the device... I submit an annual report? 803.33 Section 803.33 Food and Drugs FOOD AND DRUG...

  5. Active filter application guide. Final report

    SciTech Connect

    Not Available

    1998-01-01

    Nonlinear loads interacting with a utility can cause harmonic currents and voltages. Nonlinear loads include arcing loads, power converters that use switching devices, and saturable transformers and reactors. When reactive loads interact with harmonic sources, the results can be harmonic distortion, malfunction of harmonic sensitive equipment, and capacitor overload. To solve these harmonic disturbances, most passive harmonic filters must be custom designed to operate with site-specific conditions. Active filters, on the other hand, offer the potential of a single black-box solution that is relatively independent of system parameters. Power quality problems attributable to harmonic voltages and currents are increasing. Traditionally, passive harmonic filters have been used to solve these problems. A more recent approach for harmonic compensation uses active filters. The Active Filter Application Guide covers fundamentals of harmonics, discusses harmonic producing loads, presents harmonic filtering principles (both active and passive), and provides a step-by-step application guide for analyzing and specifying an active filter. Also included in the Guide are two active-filter case studies. Each demonstrates how the application guide can be used to select and specify solutions for both single harmonic load and multiple harmonic producing loads at a clustered site.

  6. 75 FR 75583 - Standards Governing the Release of a Suspicious Activity Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ..., or in the conduct of intelligence or counterintelligence activities, including analysis, to protect..., Organization and functions (Government agencies), Reporting and recordkeeping requirements, Women....

  7. Effects of Leisure Education Programme Including Sportive Activities on Perceived Freedom in Leisure of Adolescents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Ertuzun, Ezgi

    2015-01-01

    The objective of this experimental study is to determine the effect of leisure education programme including sportive activities on the perceived freedom in leisure of adolescents with mild intellectual disabilities. The research was designed with an experimental group (n = 37) and a control group (n = 34), and was conducted among a total of 71…

  8. Advanced light source. Activity report 1995

    SciTech Connect

    1996-07-01

    The ALS Activity Report is designed to share the breadth, variety, and interest of the scientific program and ongoing R&D efforts in a form that is accessible to a broad audience. Recent research results are presented in six sections, each representing an important theme in ALS science. These results are designed to demonstrate the capabilities of the ALS, rather than to give a comprehensive review of 1995 experiments. Although the scientific program and facilities report are separate sections, in practice the achievements and accomplishments of users and ALS staff are interdependent. This user-staff collaboration is essential to help us direct our efforts toward meeting the needs of the user community, and to ensure the continued success of the ALS as a premier facility.

  9. Autoimmunity Including Intestinal Behçet Disease Bearing the KRAS Mutation in Lymphocytes: A Case Report.

    PubMed

    Moritake, Hiroshi; Takagi, Masatoshi; Kinoshita, Mariko; Ohara, Osamu; Yamamoto, Shojiro; Moriguchi, Sayaka; Nunoi, Hiroyuki

    2016-03-01

    We experienced the case of a 3-year-old male with a very rare combination of autoimmunity, including immune thrombocytopenia, recurrent Henoch-Schönlein purpura and intestinal Behçet disease. Exome sequencing of the patient's peripheral blood mononuclear cells identified a KRAS G13C mutation. Interestingly, the KRAS G13C mutation was observed in T and B lymphocytes, as well as natural killer cells, but not granulocytes. Our case was completely phenotypically different from RASopathies and did not meet the criteria for Ras-associated lymphoproliferative disease or juvenile myelomonocytic leukemia. This is the first reported case in which the KRAS mutation existed only in the lymphoid lineage. Based on the findings of our case and the current literature, it is clear that the RAS mutation in lymphoid cells is tightly linked with various autoimmune symptoms. The presence of the RAS mutation in lymphocytes should be reconsidered as a pathogenesis in cases of autoimmunity.

  10. [Productivity of doctoral programs in Psychology with Quality Mention in journal articles included in Journal Citation Reports].

    PubMed

    Musi-Lechuga, Bertha; Olivas-Ávila, José; Castro, Angel

    2011-08-01

    The main objective of the present study was to classify doctoral programs with Quality Mention in Psychology based on their scientific productivity. For this purpose, articles in the Web of Science published by professors teaching in these doctoral programs were analyzed. In addition, we analyzed scientific journals in which these professors tend to publish more papers and the evolution in the number of papers published until 2009. Results showed that the most productive doctoral program was the Neurosciences program at the University of Oviedo. This program showed a ratio of 40 articles--published in journals included in Journal Citation Reports--by each professor. In contrast, other programs did not reach a ratio of 10 articles per professor. Regarding journals, results showed that 9 out of the 20 most popular journals are Hispanic and a gradual increase in the number of published papers was also observed. Lastly, results and implications for quality assessment are discussed.

  11. Verrucous Oesophageal Carcinoma: Single Case Report and Case Series Including 15 Patients – Issues for Consideration of Therapeutic Strategies

    PubMed Central

    Behrens, Angelika; Stolte, Manfred; Pech, Oliver; May, Andrea; Ell, Christian

    2014-01-01

    Background Verrucous carcinomas (VC) of the oesophagus are a rarity. Due to their histological resemblance to squamous cell carcinoma, the diagnostic and treatment standards applicable to the latter have so far also been applied to VC as a disease entity. Quite limited data are available including two case series of 5 or 11 patients. The present study reports on a single case treated by local endoscopic therapy and a series of 15 patients, 9 of whom received local endoscopic therapy. Methods The data for patients diagnosed with VC of the oesophagus who had been treated from January 1999 to May 2011 were analysed retrospectively. Results 15 patients with the diagnosis of oesophageal VC were included. The male-female ratio was 3:1. 9 of 11 pT1-VC patients presented with the cardinal symptom dysphagia or odynophagia. For the majority of the patients, the growth pattern is one of extensive superficial expansion showing a median length of 9 cm (range: 2-22 cm). Surprisingly, none of the VC patients showed lymph node or distant metastasis. 9 of 15 VC patients received local endoscopic therapy; 4 were treated with curative intent and 5 were treated palliatively. 3 patients underwent oesophageal resection, and definitive chemoradiotherapy was administered in a further 3 patients. One severe complication, consisting of a postoperative anastomotic insufficiency with a fatal outcome, occurred in this group of patients. Conclusion This is the largest published study describing patients diagnosed with VC of the oesophagus so far. The option of local endoscopic therapy and its results in 9 patients are reported for the first time. The superficial growth pattern of the tumour and the frequent absence of lymph node or distant metastasis suggest that endoscopic resection can be carried out as a diagnostic and/or therapeutic approach. Due to the rarity of this entity, the case numbers are unfortunately so limited that evidence-based recommendations are unlikely to become available

  12. Forty-Fourth Annual Report of the National Advisory Committee for Aeronautics Administrative Report Including Technical Reports Nos. 1342 to 1392

    NASA Technical Reports Server (NTRS)

    1959-01-01

    In accordance with act of Congress, approved March 3, 1915, as amended (U.S.C., title 50, .sw 151), which established the National Advisory Committee for Aeronautics, the Committee submits its Forty-fourth Annual Report for the fiscal year 1958. This is the Committee's final report to the Congress. The National Aeronautics and Space Act of 1958 (Public Law 85-568) provides in section 301 that the NACA "shall cease to exist" and "all functions, powers, duties, and obligations, and all real and personal property, personnel (other than members of the Committee), funds, and records of the NACA shall be transferred to the National Aeronautics and Space Administration. The aforesaid act provides that "this section shall take effect 90 days after the date of the enactment of this act, or on any earlier date on which the Administrator shall determining and announce by proclamation published in the Federal Register, that the Administration has been organized and is prepared to discharge the duties and exercise the power conferred upon it by this act." The Administrator, Hon. T. Keith Glennan has advised the Committee of his intention to issue such proclamation, effective October 1,1958.

  13. An Overview of NCRP Report No. 138 on Terrorist Activities

    NASA Astrophysics Data System (ADS)

    Poston, John, Sr.

    2005-04-01

    In late 1998, the National Council on Radiation Protection and Measurements (NCRP) convened Scientific Committee 46-14 to prepare a report on the radiological safety aspects of terrorist activities involving radioactivity. The work of this committee was funded through a contract with the Planning and Preparedness Division of the Office of Emergency Management of the Department of Energy. The committee was composed of a diverse group of individuals with expertise in many areas in addition to radiation safety and emergency response. These areas included law (both federal and state), public communications, and psychosocial aspects of such incidents. The statement of work focused the work of the committee, and the resulting report did not necessarily address all issues of such activities. One of the charges of the committee was to provide guidance as to necessary research and make recommendations regarding the present infrastructure with the responsibility for responding to such incidents. This presentation will provide an overview of NCRP Report No. 138 and focus on some of the critical issues raised in the report. These issues include recognition of the event, the interface between federal, state, and local authorities, exposure limits for the first-responders, clean-up criteria, training and resources, the psychosocial aspects of such events, and communications with the media and the public. This report represented the ``beginning'' of such considerations. It pointed the way for additional studies and research in this very important area.

  14. Macrofollicular variant of papillary carcinoma, a potential diagnostic pitfall: A report of two cases including a review of literature

    PubMed Central

    Policarpio-Nicolas, Maria Luisa C.; Sirohi, Deepika

    2013-01-01

    Macrofollicular variant of papillary thyroid carcinoma (MFVPTC) is one of the rarest histologic types of papillary carcinoma. This tumor may mimic an adenomatoid/colloid nodule or follicular neoplasm (macrofollicular type) both on histology and cytology. There are very few articles describing the cytologic features of MFVPTC. We report the cytologic findings of two surgically confirmed MFVPTC. The first case showed abundant thin colloid with moderate amount of follicular cells arranged in a honeycombed and syncytial pattern. Some but not all the follicular cells showed enlarged round to ovoid nuclei, overlapping nuclei, few nuclear grooves and rare intranuclear inclusions. The second case showed abundant thin colloid and predominantly benign appearing follicular cells with few overlapping nuclei, enlarged round to ovoid nuclei and rare nuclear grooves. No intranuclear inclusions were identified. A review of the literature was done and the cytologic findings of MFVPTC including our two cases were tabulated. The cytologic findings showed moderate to abundant thin with focally thick colloid in 75% of cases and sheet like arrangement of follicular cells in 76%. Although nuclear features such as chromatin clearing, overlapping and grooves were present in majority of cases, the quantity varied from rare to focal. Small to prominent nucleoli were present in all of the evaluable cases. Intranuclear inclusions were seen only in 45% of patients. Hence, the cytologic features of macrofollicular variant of papillary carcinoma though present can be subtle and intranuclear inclusions may not be present always. PMID:24082912

  15. Thirty-Seventh Annual Report of the National Advisory Committee for Aeronautics: Administrative Report Including Technical Report Nos. 1003 to 1958

    NASA Technical Reports Server (NTRS)

    1952-01-01

    In accordance with the act of Congress, approved March 3,1915 (U.S. C. title 50, sec. 151), which established the National Advisory Committee for Aeronautics the Committee submits its thirty-seventh annual report for the fiscal year 1951. The United States is engaged in expanding military aviation to levels never before reached except in the midst of a major war. In Korea, our military aircraft are engaged in combat with airplanes of an unfriendly nation evidently able to build military aircraft of increasing capabilities. In this environment, the NACA is responsible for conducting an adequate program of scientific research to open the way for the design of aircraft and missile of superior performance. Since World War II the pace of technical development has increased. Until then, improvement in aircraft performance as a result of the application of scientific research proceeded at what. now seems to be a relatively slow and orderly rate. Modest increases in speed, climb, range, or altitude were set as reasonable goals. Compressibility effects at high speeds were just beginning to be encountered and indicated a formidable barrier near the velocity of sound. This barrier has been found by research and experiment to be lees formidable than supposed, and we now see the possibility of radical gains in airplane performance that are of great military significance. Such gains are ak attainable by a potential enemy. The increased complexity of modern high performance

  16. Increasing resource allocation and research into tobacco control activities: a comprehensive approach including primary prevention, treatment and brief intervention.

    PubMed

    Richmond, R

    1993-01-01

    The range of tobacco control activities should be viewed as essential parts of a complex multi-component puzzle. Intervention strategies designed to address tobacco control should be comprehensive and include both primary and secondary prevention activities and be multi-faceted and capable of bringing about change at both the individual and broader social and cultural levels. In this paper I argue for a mutually inclusive framework in which the various components contribute in important and different ways. I examine the prevalence of smoking and identify the high risk groups, then I examine the range of available strategies and present the evidence for their success. I discuss the primary prevention approaches such as warning labels, taxes, price increases, workplace bans, education in schools, mass media and self-help materials, as well as brief interventions and treatment strategies which are conducted at the worksite, general practice and specialized cessation clinics. The areas for future research are delineated for increased resource allocation and include: the best ways to disseminate brief interventions to smokers, methods to motivate smokers; training of health professionals to deliver brief interventions; enhancing quitting and access to existing treatment resources among specific disadvantaged minority groups, e.g. migrants, unemployed youth, the effect on smoking prevalence of warning labels on cigarette packets and price rises on cigarettes.

  17. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Annual report of activity. 1710.310... § 1710.310 Annual report of activity. (a) As an integral part of the Statement of Record, the developer shall file with the Secretary an Annual Report of Activity on any initial or consolidated...

  18. 15 CFR 908.3 - Activities subject to reporting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-ORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.3 Activities subject to reporting. (a) The following, when conducted as weather modification activities, shall be subject to reporting... acoustic sources to the atmosphere; (7) Using aircraft propeller downwash, jet wash, or other sources...

  19. 15 CFR 908.3 - Activities subject to reporting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-ORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.3 Activities subject to reporting. (a) The following, when conducted as weather modification activities, shall be subject to reporting... acoustic sources to the atmosphere; (7) Using aircraft propeller downwash, jet wash, or other sources...

  20. 15 CFR 908.3 - Activities subject to reporting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...- ORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.3 Activities subject to reporting. (a) The following, when conducted as weather modification activities, shall be subject to reporting... acoustic sources to the atmosphere; (7) Using aircraft propeller downwash, jet wash, or other sources...

  1. 15 CFR 908.3 - Activities subject to reporting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RECORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.3 Activities subject to reporting. (a) The following, when conducted as weather modification activities, shall be subject to reporting... acoustic sources to the atmosphere; (7) Using aircraft propeller downwash, jet wash, or other sources...

  2. 15 CFR 908.3 - Activities subject to reporting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RECORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.3 Activities subject to reporting. (a) The following, when conducted as weather modification activities, shall be subject to reporting... acoustic sources to the atmosphere; (7) Using aircraft propeller downwash, jet wash, or other sources...

  3. An Antimicrobial Metabolite from Bacillus sp.: Significant Activity Against Pathogenic Bacteria Including Multidrug-Resistant Clinical Strains

    PubMed Central

    Chalasani, Ajay G.; Dhanarajan, Gunaseelan; Nema, Sushma; Sen, Ramkrishna; Roy, Utpal

    2015-01-01

    In this study, the cell free modified tryptone soya broth (pH 7.4 ± 0.2) of Bacillus subtilis URID 12.1 showed significant antimicrobial activity against multidrug-resistant strains of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes and Enterococcus faecalis. The partially purified antimicrobial molecule was found to be resistant to extremes of pH and temperatures and also to higher concentrations of trypsin and proteinase K. The antimicrobial molecule was purified by a three-step method that included reversed-phase high performance liquid chromatography (RP-HPLC). The minimum inhibitory concentration (MIC) values were determined for 14 species of bacteria using a microbroth dilution technique. The HPLC-purified fraction showed the MICs ranging from 0.5 to 16 μg/ml for methicillin and vancomycin-resistant Staphylococcus aureus (MVRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains. The molecular mass of the antimicrobial compound was determined to be 842.37 Da. The same antimicrobial fraction showed negligible haemolytic activity against human red blood cells even at a concentration as high as 100 μg/ml. Because of its significant antimicrobial activity at low MIC values coupled with its non-haemolytic property, it may prove to be a novel antimicrobial lead molecule. PMID:26696963

  4. Issues Relating to Selective Reporting When Including Non-Randomized Studies in Systematic Reviews on the Effects of Healthcare Interventions

    ERIC Educational Resources Information Center

    Norris, Susan L.; Moher, David; Reeves, Barnaby C.; Shea, Beverley; Loke, Yoon; Garner, Sarah; Anderson, Laurie; Tugwell, Peter; Wells, George

    2013-01-01

    Background: Selective outcome and analysis reporting (SOR and SAR) occur when only a subset of outcomes measured and analyzed in a study is fully reported, and are an important source of potential bias. Key methodological issues: We describe what is known about the prevalence and effects of SOR and SAR in both randomized controlled trials (RCTs)…

  5. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the NPL

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; Woods, M. J.

    2003-01-01

    Since 2001, four national metrology institutes (NMIs) have submitted four samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures, the most recent being that of the NPL (UK). The activities ranged from about 1 MBq to 8 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value and the degrees of equivalence between each equivalent activity measured in the SIR and the key comparison reference value (KCRV) have been calculated and the results are given in the form of a matrix. A graphical presentation is also given. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), comparison identifier BIPM.RI(II)-K1.F-18, according to the provisions of the Mutual Recognition Arrangement (MRA).

  6. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the CIEMAT

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; García-Toraño, E.; Los Arcos, J.-M.

    2004-01-01

    Since 2001, five national metrology institutes (NMIs) have submitted five samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), the most recent being that of the CIEMAT (Spain). The activities ranged from about 1 MBq to 18 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value and the degrees of equivalence between each equivalent activity measured in the SIR have been calculated and the results are given in the form of a matrix. A graphical presentation is also given for this key comparison with identifier BIPM.RI(II)-K1.F-18. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), according to the provisions of the Mutual Recognition Arrangement (MRA).

  7. KEY COMPARISON: Update of the BIPM comparison BIPM.RI(II)-K1.F-18 of activity measurements of the radionuclide 18F to include the PTB

    NASA Astrophysics Data System (ADS)

    Ratel, G.; Michotte, C.; Kossert, K.; Janßen, H.

    2006-01-01

    Since 2001, six national metrology institutes (NMIs) have submitted six samples of known activity of 18F to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), the most recent being that of the PTB (Germany). The activities ranged from about 1 MBq to 18 MBq. The key comparison reference value (KCRV) has been recalculated to include the latest value, with the agreement of the CCRI(II). The degrees of equivalence between each equivalent activity measured in the SIR have been recalculated and the results are given in the form of a matrix. A graphical presentation is also given for this key comparison with identifier BIPM.RI(II)-K1.F-18. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by Section II of the Consultative Committee for Ionizing Radiation (CCRI(II)), according to the provisions of the Mutual Recognition Arrangement (MRA).

  8. PITBUL: a physics-based modeling package for imaging and tracking of airborne targets for HEL applications including active illumination

    NASA Astrophysics Data System (ADS)

    Van Zandt, Noah R.; McCrae, Jack E.; Fiorino, Steven T.

    2013-05-01

    Aimpoint acquisition and maintenance is critical to high energy laser (HEL) system performance. This study demonstrates the development by the AFIT/CDE of a physics-based modeling package, PITBUL, for tracking airborne targets for HEL applications, including atmospheric and sensor effects and active illumination, which is a focus of this work. High-resolution simulated imagery of the 3D airborne target in-flight as seen from the laser position is generated using the HELSEEM model, and includes solar illumination, laser illumination, and thermal emission. Both CW and pulsed laser illumination are modeled, including the effects of illuminator scintillation, atmospheric backscatter, and speckle, which are treated at a first-principles level. Realistic vertical profiles of molecular and aerosol absorption and scattering, as well as optical turbulence, are generated using AFIT/CDE's Laser Environmental Effects Definition and Reference (LEEDR) model. The spatially and temporally varying effects of turbulence are calculated and applied via a fast-running wave optical method known as light tunneling. Sensor effects, for example blur, sampling, read-out noise, and random photon arrival, are applied to the imagery. Track algorithms, including centroid and Fitts correlation, as a part of a closed loop tracker are applied to the degraded imagery and scored, to provide an estimate of overall system performance. To gauge performance of a laser system against a UAV target, tracking results are presented as a function of signal to noise ratio. Additionally, validation efforts to date involving comparisons between simulated and experimental tracking of UAVs are presented.

  9. Low-rank coal research. Final technical report, April 1, 1988--June 30, 1989, including quarterly report, April--June 1989

    SciTech Connect

    Not Available

    1989-12-31

    This work is a compilation of reports on ongoing research at the University of North Dakota. Topics include: Control Technology and Coal Preparation Research (SO{sub x}/NO{sub x} control, waste management), Advanced Research and Technology Development (turbine combustion phenomena, combustion inorganic transformation, coal/char reactivity, liquefaction reactivity of low-rank coals, gasification ash and slag characterization, fine particulate emissions), Combustion Research (fluidized bed combustion, beneficiation of low-rank coals, combustion characterization of low-rank coal fuels, diesel utilization of low-rank coals), Liquefaction Research (low-rank coal direct liquefaction), and Gasification Research (hydrogen production from low-rank coals, advanced wastewater treatment, mild gasification, color and residual COD removal from Synfuel wastewaters, Great Plains Gasification Plant, gasifier optimization).

  10. A proposed 30-45 minute 4 page standard protocol to evaluate rheumatoid arthritis (SPERA) that includes measures of inflammatory activity, joint damage, and longterm outcomes.

    PubMed

    Pincus, T; Brooks, R H; Callahan, L F

    1999-02-01

    A proposed 4 page, 30-45 minute standard protocol to assess rheumatoid arthritis (SPERA) is described that includes all relevant measures of inflammatory activity such as joint swelling, measures of joint damage such as joint deformity, and outcomes such as joint replacement surgery, to monitor patients in longterm observational studies. Forms are included: (1) a patient self-report modified health assessment questionnaire (MHAQ) to assess function, pain, fatigue, psychological distress, symptoms, and drugs used; (2) assessor-completed forms: "RA clinical features" --criteria for RA, functional class, family history, extraarticular disease, comorbidities, joint surgery, radiographic score, and laboratory findings. (3) A 32 joint count with 5 variables: (a) a "shorthand" normal/abnormal so that normal joints require no further detailed assessment; (b) tenderness or pain on motion; (c) swelling; (d) limited motion or deformity; (e) previous surgeries; physical measures of function, i.e., grip strength, walk time, and button test. (4) Medication review of previous disease modifying antirheumatic drugs (DMARD), work history, and years of education. The forms allow cost effective acquisition of all relevant measures of activity, damage, and outcomes in routine clinical care, and allow recognition that measures of activity may show similar or improved values over 5-10 years, while measures of damage and outcomes indicate severe progression in the same patients. The SPERA is feasible to acquire most known relevant measures of activity, damage, and outcomes in RA in 30-45 min in usual clinical settings, to provide a complete database for analyses of longterm outcomes.

  11. 1999 Survey of Active Duty Personnel: Statistical Methodology Report

    DTIC Science & Technology

    2000-09-01

    6218 Ask for report by ADA 386 288 DMDC Report No. 2000-010 September 2000 1999 SURVEY OF ACTIVE DUTY PERSONNEL: STATISTICAL METHODOLOGY REPORT...STATISTICAL METHODOLOGY REPORT Executive Summary This report describes the sampling design, sample selection, estimation procedures, and the missing data

  12. Central activation of the sympathetic nervous system including the adrenals in anaesthetized guinea pigs by the muscarinic agonist talsaclidine.

    PubMed

    Walland, A; Pieper, M P

    1998-04-01

    Talsaclidine, a novel M1-receptor selective muscarinic agonist for cholinergic substitution therapy of Alzheimer's disease, activates the sympathetic nervous system in guinea pigs and dogs at the orthosympathic ganglia and the paraganglionic adrenals. Results from guinea pigs provide indirect evidence for an additional central site of action. The present investigation in anaesthetized and vagotomized guinea pigs intended to demonstrate central activation of the sympathetic nervous system directly by comparing the blood pressure effects of intracerebroventricular and intravenous injections of small doses of talsaclidine. Increasing doses of 0.2 and 0.6 mg/kg talsaclidine were injected alternately into the third cerebral ventricle and intravenously in 6 guinea pigs before and after blockade of peripheral muscarinic receptors with 1 mg/kg ipratropium bromide i.v. In another group of 6 animals the injections were given into the cisterna cerebellomedullaris using the same protocol. In both groups central administration of talsaclidine caused dose-related hypertension while intravenous injections were hypotensive. Ipratropium bromide, a peripheral antimuscarinic drug, reversed this hypotensive action of intravenous talsaclidine into hypertension, but did not inhibit the effects of central administration. In contrast, atropine, an antimuscarinic drug which passes the blood-brain barrier, abolished the effect of 0.6 mg/kg talsaclidine injected into the cisterna cerebellomedullaris of 8 guinea pigs. The hypertensive effect of a first injection of 0.6 mg/kg talsaclidine into the cisterna cerebellomedullaris of 6 guinea pigs was approximately twice as large as that of a second given 90 min after bilateral adrenalectomy. Sham operation in another 6 animals was not inhibitory. The results demonstrate that talsaclidine, a selective muscarinic M1-receptor agonist, activates central parts of the sympathetic nervous system, including central projections of the adrenals by an action

  13. 42 CFR 137.202 - What types of information will Self-Governance Tribes be expected to include in the reports?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What types of information will Self-Governance... SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.202 What types of information will Self-Governance Tribes be expected to include in the reports? Reports will be derived from...

  14. Aeronautics and space report of the President: 1981 activities

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Achievements in the aeronautics and space program by function are summarized. Activities in communications, Earth's resources and environment, space science, space transportation, international activities, and aeronautics are included.

  15. 1990 Activity report for 1986-1992

    SciTech Connect

    Cantwell, K.

    1996-01-01

    As discussed in last year`s Activity Report, a fairly complete analysis of SPEAR problems was performed in concert with SLAC, and a major maintenance/improvement process was initiated in the spring of 1989. This run made it apparent that SPEAR will remain a very useful and impressive synchrotron radiation storage ring for at least a decade, given a steady maintenance and improvement program. More details about SPEAR functioning during the run, as well as SPEAR improvements, are contained in Chapter I. The formal SPEAR injector construction project was completed in November, 1990, on-time and on-budget. Although DOE was not able to provide anticipated FY90 commissioning funds, preliminary commissioning was performed and 2.3 GeV injection to SPEAR was demonstrated. A discussion of the Injector project is contained in Chapter II. Commissioning of the injector and the injector/SPEAR complex is continuing in 1991 with Users participating during the May-September period. This user participation allowed normal experimentation, so that systems could be tested critically, but with the commissioning process having higher priority than data acquisition. Another major event in 1990 was the full dedication of SPEAR to the synchrotron radiation program. Previously SPEAR was considered a high energy physics machine that was partially dedicated to synchrotron radiation. The full dedication means that the accelerator can be modified and improved for synchrotron radiation research. Despite the heavy emphasis on completing the Injector, many beam line improvements were achieved, as described in Chapter IV. Among these was the optimization of stations 6-2 and 10-2, the provision of a considerably larger hutch for Station 1-5, which contains the area detector diffractometer, and the introduction of white light capability on 10-2. The provision of good beam during the month of April made an appreciable amount of experimentation possible. These and other runs are described in Chapter VI.

  16. Hallucinogens and Dissociative Drugs, Including LSD, PCP, Ketamine, Dextromethorphan. National Institute on Drug Abuse Research Report Series.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHHS/PHS), Rockville, MD.

    Research is developing a clearer picture of the dangers of mind-altering drugs. The goal of this report is to present the latest information to providers to help them strengthen their prevention and treatment efforts. A description is presented of dissociative drugs, and consideration is given as to why people take hallucinogens. The physical…

  17. Statewide Project to Include Aging Content in Colleges of Pharmacy. An Administration on Aging Project. Final Report.

    ERIC Educational Resources Information Center

    Rousch, Robert

    The project described in this report was designed to: (1) address the lack of adequately trained faculty members needed to introduce geriatrics within colleges of pharmacy, (2) facilitate the use of existing materials within the educational program provided pharmacy students, (3) teach a geriatric pharmacy course twice at each of Texas' three…

  18. Activation of CpxRA in Haemophilus ducreyi primarily inhibits the expression of its targets, including major virulence determinants.

    PubMed

    Gangaiah, Dharanesh; Zhang, Xinjun; Fortney, Kate R; Baker, Beth; Liu, Yunlong; Munson, Robert S; Spinola, Stanley M

    2013-08-01

    Haemophilus ducreyi causes chancroid, a genital ulcer disease that facilitates the transmission of human immunodeficiency virus type 1. In humans, H. ducreyi is surrounded by phagocytes and must adapt to a hostile environment to survive. To sense and respond to environmental cues, bacteria frequently use two-component signal transduction (2CST) systems. The only obvious 2CST system in H. ducreyi is CpxRA; CpxR is a response regulator, and CpxA is a sensor kinase. Previous studies by Hansen and coworkers showed that CpxR directly represses the expression of dsrA, the lspB-lspA2 operon, and the flp operon, which are required for virulence in humans. They further showed that CpxA functions predominantly as a phosphatase in vitro to maintain the expression of virulence determinants. Since a cpxA mutant is avirulent while a cpxR mutant is fully virulent in humans, CpxA also likely functions predominantly as a phosphatase in vivo. To better understand the role of H. ducreyi CpxRA in controlling virulence determinants, here we defined genes potentially regulated by CpxRA by using RNA-Seq. Activation of CpxR by deletion of cpxA repressed nearly 70% of its targets, including seven established virulence determinants. Inactivation of CpxR by deletion of cpxR differentially regulated few genes and increased the expression of one virulence determinant. We identified a CpxR binding motif that was enriched in downregulated but not upregulated targets. These data reinforce the hypothesis that CpxA phosphatase activity plays a critical role in controlling H. ducreyi virulence in vivo. Characterization of the downregulated genes may offer new insights into pathogenesis.

  19. 75 FR 75586 - Confidentiality of Suspicious Activity Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... Office of Thrift Supervision 12 CFR Part 563 RIN 1550-AC26 Confidentiality of Suspicious Activity Reports... confidentiality of a suspicious activity report (SAR) to: Clarify the scope of the statutory prohibition on the... keep certain records and make certain reports that have been determined to be useful in criminal,...

  20. 12 CFR 1282.63 - Annual Housing Activities Report.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Annual Housing Activities Report. 1282.63 Section 1282.63 Banks and Banking FEDERAL HOUSING FINANCE AGENCY HOUSING GOALS AND MISSION ENTERPRISE HOUSING GOALS AND MISSION Reporting Requirements § 1282.63 Annual Housing Activities Report. To...

  1. 12 CFR 1282.63 - Annual Housing Activities Report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Annual Housing Activities Report. 1282.63 Section 1282.63 Banks and Banking FEDERAL HOUSING FINANCE AGENCY HOUSING GOALS AND MISSION ENTERPRISE HOUSING GOALS AND MISSION Reporting Requirements § 1282.63 Annual Housing Activities Report. To...

  2. 12 CFR 1282.63 - Annual Housing Activities Report.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Annual Housing Activities Report. 1282.63 Section 1282.63 Banks and Banking FEDERAL HOUSING FINANCE AGENCY HOUSING GOALS AND MISSION ENTERPRISE HOUSING GOALS AND MISSION Reporting Requirements § 1282.63 Annual Housing Activities Report. To...

  3. Self-Reported Health Experiences of Children Living with Congenital Heart Defects: Including Patient-Reported Outcomes in a National Cohort Study

    PubMed Central

    Tadic, Valerija; Hogan, Ailbhe; Bull, Catherine; Rahi, Jugnoo Sangeeta; Dezateux, Carol

    2016-01-01

    Background Understanding children’s views about living with congenital heart defects (CHDs) is fundamental to supporting their successful participation in daily life, school and peer relationships. As an adjunct to a health and quality of life outcomes questionnaire, we asked school-age children who survived infant heart procedures to describe their experiences of living with CHDs. Methods In a UK-wide cohort study, children aged 10 to 14 years with CHDs self-completed postal questionnaires that included an open question about having a ‘heart problem’. We compared the characteristics of children with more and less severe cardiac diagnoses and, through collaborative inductive content analysis, investigated the subjective experiences and coping strategies described by children in both clinical severity groups. Results Text and/or drawings were returned by 436 children (246 boys [56%], mean age 12.1 years [SD 1.0; range 10–14]); 313 had less severe (LS) and 123 more severe (MS) cardiac diagnoses. At the most recent hospital visit, a higher proportion of the MS group were underweight (more than two standard deviations below the mean for age) or cyanosed (underweight: MS 20.0%, LS 9.9%; cyanosed: MS 26.2%, LS 3.5%). Children in the MS group described concerns about social isolation and feeling ‘different’, whereas children with less severe diagnoses often characterised their CHD as ‘not a big thing’. Some coping strategies were common to both severity groups, including managing health information to avoid social exclusion, however only children in the LS group considered their CHD ‘in the past’ or experienced a sense of survivorship. Conclusions Children’s reported experiences were not dependent on their cardiac diagnosis, although there were clear qualitative differences by clinical severity group. Children’s concerns emphasised social participation and our findings imply a need to shift the clinical focus from monitoring cardiac function to

  4. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon to...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5...-hour block average carbon feed rate (calculated from the carbon injection system operating...

  5. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon to...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5...-hour block average carbon feed rate (calculated from the carbon injection system operating...

  6. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon to...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5...-hour block average carbon feed rate (calculated from the carbon injection system operating...

  7. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon to...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5...-hour block average carbon feed rate (calculated from the carbon injection system operating...

  8. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon to...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5...-hour block average carbon feed rate (calculated from the carbon injection system operating...

  9. Active harmonic filter technology and market assessment. Final report

    SciTech Connect

    Bhattacharya, S.; Divan, D.; Sutherland, P.

    1998-08-01

    Non-linear loads such as three-phase rectifiers, adjustable speed drives (ASDs), and arcing loads can cause voltage distortion and other power quality problems due to their interaction with the power grid. This report provides a technical and marketing assessment of active harmonic filters, a promising approach to preventing these problems at their source. Although predicting the direction and magnitude of harmonic currents is difficult due to highly interconnected nature of distribution systems, even small harmonic producing loads can result in high levels of harmonic current flow between the utility and a customer and can also cause a resonance problem at sites far removed from the harmonic producing load. The best way to keep voltage distortion low in a utility system is to constrain the harmonic currents at their sources. However, since regulation of harmonic pollution does not provide any additional value to the customer, it is unlikely that any controls will be implemented on a consistent basis in the absence of mandatory requirements. In the United States, a step toward a standard operating practice is the IEEE 519-1992 recommended harmonic standard that provides guidelines for limiting harmonic currents by industrial plants. This report identifies the equipment likely to produce harmonic loads and explains the kinds of problems that harmonic currents can cause in a utility distribution system. It describes possible solutions to these problems, including harmonic filtering and other technologies. The report examines the prospects for wider use of active harmonic filter technology and discusses the important marketing issues for potential active filter marketers and manufacturers, such as the barriers to and drivers of increased use of active filter technology and the price points for active filters.

  10. Antimicrobial Active Packaging including Chitosan Films with Thymus vulgaris L. Essential Oil for Ready-to-Eat Meat.

    PubMed

    Quesada, Jesús; Sendra, Esther; Navarro, Casilda; Sayas-Barberá, Estrella

    2016-08-29

    An active packaging system has been designed for the shelf life extension of ready to eat meat products. The package included an inner surface coated with a chitosan film with thyme essential oil (0%, 0.5%, 1%, and 2%) not in direct contact with the meat. Our aim was to reduce the impact of thyme essential oil (EO) on meat sensory properties by using a chemotype with low odor intensity. The pH, color parameters, microbial populations, and sensory properties were assessed during 4 weeks of refrigerated storage. The presence of EO films reduced yeast populations, whereas aerobic mesophilic bacteria, lactic acid bacteria, and enterobacteria were not affected by the presence of the EO in the films. Meat color preservation (a *) was enhanced in the presence of EO, giving a better appearance to the packaged meat. The presence of the chitosan-EO layer reduced water condensation inside the package, whereas packages containing only chitosan had evident water droplets. Thyme odor was perceived as desirable in cooked meat, and the typical product odor intensity decreased by increasing the EO concentration. Further studies should point towards developing oil blends or combinations with natural antimicrobial agents to be incorporated into the film to improve its antimicrobial properties.

  11. Antimicrobial Active Packaging including Chitosan Films with Thymus vulgaris L. Essential Oil for Ready-to-Eat Meat

    PubMed Central

    Quesada, Jesús; Sendra, Esther; Navarro, Casilda; Sayas-Barberá, Estrella

    2016-01-01

    An active packaging system has been designed for the shelf life extension of ready to eat meat products. The package included an inner surface coated with a chitosan film with thyme essential oil (0%, 0.5%, 1%, and 2%) not in direct contact with the meat. Our aim was to reduce the impact of thyme essential oil (EO) on meat sensory properties by using a chemotype with low odor intensity. The pH, color parameters, microbial populations, and sensory properties were assessed during 4 weeks of refrigerated storage. The presence of EO films reduced yeast populations, whereas aerobic mesophilic bacteria, lactic acid bacteria, and enterobacteria were not affected by the presence of the EO in the films. Meat color preservation (a *) was enhanced in the presence of EO, giving a better appearance to the packaged meat. The presence of the chitosan-EO layer reduced water condensation inside the package, whereas packages containing only chitosan had evident water droplets. Thyme odor was perceived as desirable in cooked meat, and the typical product odor intensity decreased by increasing the EO concentration. Further studies should point towards developing oil blends or combinations with natural antimicrobial agents to be incorporated into the film to improve its antimicrobial properties. PMID:28231152

  12. National Synchrotron Light Source 2010 Activity Report

    SciTech Connect

    Rowe, M.; Snyder, K. J.

    2010-12-29

    This is a very exciting period for photon sciences at Brookhaven National Laboratory. It is also a time of unprecedented growth for the Photon Sciences Directorate, which operates the National Synchrotron Light Source (NSLS) and is constructing NSLS-II, both funded by the Department of Energy's Office of Science. Reflecting the quick pace of our activities, we chose the theme 'Discovery at Light Speed' for the directorate's 2010 annual report, a fiscal year bookended by October 2009 and September 2010. The year began with the news that NSLS users Venki Ramakrishnan of Cambridge University (also a former employee in Brookhaven's biology department) and Thomas A. Steitz of Yale University were sharing the 2009 Nobel Prize in Chemistry with Ada E. Yonath of the Weizmann Institute of Science. Every research project has the potential for accolades. In 2010, NSLS users and staff published close to 900 papers, with about 170 appearing in premiere journals. Those are impressive stats for a facility nearly three decades old, testament to the highly dedicated team keeping NSLS at peak performance and the high quality of its user community. Our NSLS users come from a worldwide community of scientists using photons, or light, to carry out research in energy and environmental sciences, physics, materials science, chemistry, biology and medicine. All are looking forward to the new capabilities enabled by NSLS-II, which will offer unprecedented resolution at the nanoscale. The new facility will produce x-rays more than 10,000 times brighter than the current NSLS and host a suite of sophisticated instruments for cutting-edge science. Some of the scientific discoveries we anticipate at NSLS-II will lead to major advances in alternative energy technologies, such as hydrogen and solar. These discoveries could pave the way to: (1) catalysts that split water with sunlight for hydrogen production; (2) materials that can reversibly store large quantities of electricity or hydrogen; (3

  13. Including Culturally and Linguistically Diverse Students in Standards-Based Reform: A Report on McREL's Diversity Roundtable I.

    ERIC Educational Resources Information Center

    Gaddy, Barbara, Ed.

    This document presents four research-based papers that were the catalyst for discussions at the first Mid-Continent Research for Education and Learning diversity roundtable in 1998. The goals established for this roundtable included: building participants' capacity for working with diverse populations; providing a catalyst for participants to…

  14. TUNL XIX. Annual report, January 1-December 31, 1980. [North Carolina State Univ. activities at TUNL

    SciTech Connect

    1980-12-31

    Research performed by North Carolina State University personnel at TUNL is highlighted in this report, which is actually the complete TUNL progress report for 1980. Studies in the areas of neutron cross sections, neutron polarization, radiative capture, atomic physics and development activities are included. One may expect completed projects to be reported in physics journals or conference proceedings. (RWR)

  15. Multiple hypothesis correction is vital and undermines reported mtDNA links to diseases including AIDS, cancer, and Huntingdon's.

    PubMed

    Johnston, Iain G

    2016-09-01

    The ability to sequence mitochondrial genomes quickly and cheaply has led to an explosion in available mtDNA data. As a result, an expanding literature is exploring links between mtDNA features and susceptibility to, or prevalence of, a range of diseases. Unfortunately, this great technological power has not always been accompanied by great statistical responsibility. I will focus on one aspect of statistical analysis, multiple hypothesis correction, that is absolutely required, yet often absolutely ignored, for responsible interpretation of this literature. Many existing studies perform comparisons between incidences of a large number (N) of different mtDNA features and a given disease, reporting all those yielding p values under 0.05 as significant links. But when many comparisons are performed, it is highly likely that several p values under 0.05 will emerge, by chance, in the absence of any underlying link. A suitable correction (for example, Bonferroni correction, requiring p < 0.05/N) must, therefore, be employed to avoid reporting false positive results. The absence of such corrections means that there is good reason to believe that many links reported between mtDNA features and various diseases are false; a state of affairs that is profoundly negative both for fundamental biology and for public health. I will show that statistics matching those claimed to illustrate significant links can arise, with a high probability, when no such link exists, and that these claims should thus be discarded until results of suitable statistical reliability are provided. I also discuss some strategies for responsible analysis and interpretation of this literature.

  16. U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)

    USGS Publications Warehouse

    Tony K. Meunier Edited by Williams, Richard S.; Ferrigno, Jane G.

    2007-01-01

    international) programs in biology, geology, geophysics, hydrology, and mapping. Therefore, the USGS was the obvious choice for these tasks, because it already had a professional staff of experienced mapmakers, scientists, and program managers with the foresight, dedication, and understanding of the need for accurate maps to support the science programs in Antarctica when asked to do so by the U.S. National Academy of Sciences. Public Laws 85-743 and 87-626, signed in August 1958, and in September 1962, respectively, authorized the Secretary, U.S. Department of the Interior, through the USGS, to support mapping and scientific work in Antarctica (Meunier, 1979 [2007], appendix A). Open-File Report 2006-1116 includes scanned facsimiles of postal cachets. It has become an international practice to create postal cachets to commemorate special events and projects in Antarctica. A cachet is defined as a seal or commemorative design printed or stamped on an envelope to mark a philatelic or special event. The inked impression illustrates to the scientist, historian, stamp collector, and general public the multidisciplinary science projects staffed by USGS and collaborating scientists during the field season. Since 1960, philatelic cachets have been created by team members for each USGS field season and, in most cases, these cachets depict the specific geographic areas and field season program objectives. The cachets become a convenient documentation of the people, projects, and geographic places of interest for that year. Because the cachets are representative of USGS activities, each year's cachet is included as a digital facsimile in that year's Open-File Report. In the 1980s, multiple USGS cachets were prepared each year, one for use by the winter team at Amundsen-Scott South Pole Station and the other for the project work areas of the austral summer field season programs.

  17. 2001 NSLS ACTIVITY REPORT (NATIONAL SYNCHROTRON LIGHT SOURCE).

    SciTech Connect

    CORWIN, M.A.

    2002-05-01

    The year 2001 has been another highly productive year at the NSLS, with over 2500 users, including 720 first time users, conducting nearly 1200 experiments in fields ranging from the life, materials, chemical, and environmental sciences to applied science and technology. An impressive array of highlights from this scientific activity is included in this Activity Report. They include the first demonstration of a direct structural probe of the superconducting ground state in the cuprates by utilizing anomalous soft x-ray resonance effects to selectively enhance the scattering from doped holes. Another highly significant result was the determination of the structure of the potassium channel membrane protein. This is especially significant as it provides insight into how the channel functions and how it selects a particular kind of ion. In the nanoscience area, small angle x-ray scattering measurements played an essential role in determining that preferential sequestering of tailored metal nanocrystals into a self-assembled lamellar diblock copolymer can produce high quality metallodielectric photonic bandgap structures, demonstrating the potential of these nanocomposites for photonic crystal engineering. The infrared microscopy program continued to yield noteworthy results, including an important study that characterized the types and abundances of organic materials in contaminated and uncontaminated sediments from the New York/New Jersey Harbor. These results will be useful in devising improved methods for the destruction or removal of these environmental contaminants.

  18. INTERNATIONAL REPORT: Practical realization of the definition of the metre, including recommended radiations of other optical frequency standards (2003)

    NASA Astrophysics Data System (ADS)

    Felder, R.

    2005-08-01

    In 2003, the International Committee for Weights and Measures (CIPM) recommended updated values of the frequency for certain optical frequency standards recommended for the practical realization of the definition of the metre. The text of this CIPM Recommendation and details of the updated radiations are given here. The complete updated set of recommended radiations, including frequencies, wavelengths, uncertainties and operating conditions where appropriate, is available on the BIPM website.

  19. Recovery Efficiency Test Project: Phase 1, Activity report

    SciTech Connect

    Overbey, W.K. Jr.; Wilkins, D.W.; Keltch, B.; Saradji, B.; Salamy, S.P.

    1988-04-01

    This report is the second volume of the Recovery Efficiency Test Phase I Report of Activities. Volume 1 covered selection, well planning, drilling, coring, logging and completion operations. This volume reports on well testing activities, reclamation activities on the drilling site and access roads, and the results of physical and mechanical properties tests on the oriented core material obtained from a horizontal section of the well. 3 refs., 21 figs., 10 tabs.

  20. Advanced Light Source Activity Report 2002

    SciTech Connect

    Duque, Theresa; Greiner, Annette; Moxon, Elizabeth; Robinson, Arthur; Tamura, Lori

    2003-06-12

    This annual report of the Advanced Light Source details science highlights and facility improvements during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  1. Physical Activity | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  2. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Reports and other reports and statements. (a) Periodic reports. Each savings association and service corporation thereof shall make such periodic or other reports of its affairs in such manner and on such forms... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Suspicious Activity Reports and other...

  3. 12 CFR 163.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Reports and other reports and statements. (a) Periodic reports. Each savings association and service... provide that reports filed by savings associations or service corporations to meet the requirements of... savings associations and service corporations file a Suspicious Activity Report when they detect a...

  4. Survey of tracking systems and rotary joints for coolant piping. Final report, August 15, 1978-August 14, 1978. [Includes patents

    SciTech Connect

    Furaus, J P; Gruchalla, M E; Sower, G D

    1980-01-01

    Problems were surveyed and evaluated with respect to solar tracking mechanisms and rotary joints for coolant piping. An analytical development of celestial mechanics, one- and two-axis tracking configurations and the effect of tracking accuracy versus collector efficiency are reported. Daily operational requirements and tracking modes were defined and evaluated. A literature and patent search on solar tracking technology was performed. Tracking system and control system performance specifications were determined. Alternative conceptual tracking approaches were defined and a cost and performance evaluation of a mechanical tracking concept was performed. Fluid coupling service specifications were determined. The cost and performance of several types of actuators and error detectors were evaluated with respect to solar tracking mechanisms.

  5. Sudden hearing loss and vertigo after tooth extraction successfully treated with combined therapy including HBO2: a case report.

    PubMed

    Yilmaz, Huseyin Baki; Erdogan, Raziye Banu Atalay; Paksoy, Mustafa; Sanli, Arif

    2015-01-01

    Sudden sensorineural hearing loss (SSNHL) is a decrease in hearing of at least 30 dB that occurs within three days and which affects at least three consecutive frequencies in either ear or both ears. This case report describes a woman who had sudden hearing loss and vertigo in the right ear after tooth extraction. As the first-line therapy, systemic and intratympanic steroid injections were used this led to a slight improvement; however, the majority of improvement in hearing was not observed until hyperbaric oxygen (HBO2) therapy was instituted on the 20th day of hearing loss. Sudden hearing loss and vertigo after tooth extraction is an otologic emergency and early evaluation and treatment are effective. HBO2, although employed beyond the Undersea and Hyperbaric Medical Society's recommended initial 14 days of symptom onset, very was effective for this particular case.

  6. SORBENT DEVELOPMENT FOR MERCURY CONTROL. Final topical report including semiannual for January 1, 1998 through June 30, 1998.

    SciTech Connect

    David J. Hassett; Edwin S. Olson; Grant E. Dunham; Ramesh K. Sharma; Ronald C. Timpe; Stanley J. Miller

    1998-10-01

    The US Environmental Protection Agency (EPA) draft Mercury Study Report to Congress (1) estimated anthropogenic mercury emissions to be 253 tons/yr in the US, with the majority (216 tons/yr) from combustion sources. The three main combustion sources listed were coal (72 tons/yr), medical waste incinerators (65 tons/yr), and municipal waste combustors (64 tons/yr). The emissions from both medical waste incinerators and municipal waste combustors were recently regulated, which, together with the reduction of mercury in consumer products such as batteries and fluorescent lights, has already reduced the emissions from these sources, as stated in the final EPA Mercury Report to Congress (2). EPA now estimates total point-source mercury emissions to be 158 tons/yr, with coal remaining at 72 tons/yr, while medical waste incinerators are down to 16 tons/yr and municipal waste combustors are at 30 tons/yr. Coal is now the primary source of anthropogenic mercury emissions in the US, accounting for 46%. In addition, the use of coal in the US has been increasing every year and passed the 1-billion-ton-per-year mark for the first time in 1997 (3). At the current rate of increase, coal consumption would reach 1.4 billion tons annually by the year 2020. On a worldwide basis, the projected increase in coal usage over the next two decades in China, India, and Indonesia will dwarf the current US coal consumption level. Therefore, in the US coal will be the dominant source of mercury emissions and worldwide coal may be the cause of significantly increased mercury emissions unless an effective control strategy is implemented. However, much uncertainty remains over the most technically sound and cost-effective approach for reducing mercury emissions from coal-fired boilers, and a number of critical research needs will have to be met to develop better control (2).

  7. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

    PubMed

    Pfäffle, Heike N; Wang, Meng; Gheorghiu, Liliana; Ferraiolo, Natalie; Greninger, Patricia; Borgmann, Kerstin; Settleman, Jeffrey; Benes, Cyril H; Sequist, Lecia V; Zou, Lee; Willers, Henning

    2013-10-15

    In patients with lung cancer whose tumors harbor activating mutations in the EGF receptor (EGFR), increased responses to platinum-based chemotherapies are seen compared with wild-type cancers. However, the mechanisms underlying this association have remained elusive. Here, we describe a cellular phenotype of cross-linker sensitivity in a subset of EGFR-mutant lung cancer cell lines that is reminiscent of the defects seen in cells impaired in the Fanconi anemia pathway, including a pronounced G2-M cell-cycle arrest and chromosomal radial formation. We identified a defect downstream of FANCD2 at the level of recruitment of FAN1 nuclease and DNA interstrand cross-link (ICL) unhooking. The effect of EGFR mutation was epistatic with FANCD2. Consistent with the known role of FANCD2 in promoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells also exhibited an impaired RAD51 foci response to ICLs, but not to DNA double-strand breaks. EGFR kinase inhibition affected RAD51 foci formation neither in EGFR-mutant nor wild-type cells. In contrast, EGFR depletion or overexpression of mutant EGFR in wild-type cells suppressed RAD51 foci, suggesting an EGFR kinase-independent regulation of DNA repair. Interestingly, EGFR-mutant cells treated with the PARP inhibitor olaparib also displayed decreased FAN1 foci induction, coupled with a putative block in a late HRR step. As a result, EGFR-mutant lung cancer cells exhibited olaparib sensitivity in vitro and in vivo. Our findings provide insight into the mechanisms of cisplatin and PARP inhibitor sensitivity of EGFR-mutant cells, yielding potential therapeutic opportunities for further treatment individualization in this genetically defined subset of lung cancer.

  8. Uranium potential of southwestern New Mexico (southern Hidalgo County), including observations on crystallization history of lavas and ash tuffs and the release of uranium from them. Final report

    SciTech Connect

    Walton, A.W.; Salter, T.L.; Zetterlund, D.

    1980-08-01

    Geological environments present in southwestern New Mexico include thick sequences of sedimentary rock including limestone, conglomerates, sandstone, and shale: igneous intrusions with associated metal deposits; caldera centers, margins, and outflow facies; and basins with marginal faults and thick late Cenozoic sedimentary fillings. Predominant rock types are Paleozoic carbonates, Mesozoic terrigeneous rocks and carbonates, and Cenozoic volcanic rocks and basin-filling terrigeneous rocks. Consideration of information available in Preliminary Reconnaissance Reports and in Hydrogeochemical and Stream Reconnaissance Reports together with 347 new whole rock chemical analyses points to three areas of anomalous uranium abundance in Hidalgo County, New Mexico. The area has experienced three major periods of igneous activity in Phanerozoic time: one associated with the Laramide cycle of the Late Cretaceous and early Tertiary, mid-Tertiary cycle of silicic volcanism with abundant calderas, and a late Tertiary cycle of mafic volcanism. Silicic volcanic rocks are the most common exposed rock type in the area, and the most enriched in uranium (range, 0.4 to 19 ppM). The most likely source for any uranium ore-forming solutions lies with this cycle of volcanism. Solutions might have been introduced during volcanism or formed later by groundwater leaching of cooled volcanic rocks. Results indicate that groundwater leaching of cooled volcanic rocks was not an effective means of mobilizing uranium in the area. Study of several rhyolite lava flows indicates that they were emplaced in supercooled condition and may have crystallized completely at temperatures well below their liquids, or they may have warmed as crystallization released latent heat. Statistical comparison of the uranium concentration revealed no differences between vitrophyres and associated felsites.

  9. A New Species of Graphis and New Lichen Records from Vietnam, Including a Second Worldwide Report of Sarcographina cyclospora

    PubMed Central

    Joshi, Santosh; Jayalal, Udeni; Oh, Soon-Ok; Nguyen, Thi Thuy; Dzung, Nguyen Anh

    2014-01-01

    Graphis upretii is a new lichen species discovered in Vietnam. The species is characterized by a loosely corticate, rough, whitish grey to greyish green thallus, elongate and irregularly branched lirellae with an apically thin complete thalline margin (negrosina morph), laterally carbonized, entire proper exciple, clear hymenium, hyaline, 16~20 transversely locular ascospores, and about 50~95 × 10~15 µm in size. In addition, members of the taxon produce norstictic and stictic acids. Currently, the lichen flora of Vietnam include Arthonia radiata, Brigantiaea tricolor, Coenogonium implexum, Dirina paradoxa, Herpothallon sipmanii, Pertusaria pertusa, and Sarcographina cyclospora. PMID:24808729

  10. NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 1998.

    SciTech Connect

    ROTHMAN,E.

    1999-05-01

    In FY 1998, following the 50th Anniversary Year of Brookhaven National Laboratory, Brookhaven Science Associates became the new Managers of BNL. The new start is an appropriate time to take stock of past achievements and to renew or confirm future goals. During the 1998 NSLS Annual Users Meeting (described in Part 3 of this Activity Report), the DOE Laboratory Operations Board, Chaired by the Under Secretary for Energy, Ernest Moniz met at BNL. By chance all the NSLS Chairmen except Martin Blume (acting NSLS Chair 84-85) were present as recorded in the picture. Under their leadership the NSLS has improved dramatically: (1) The VUV Ring current has increased from 100 mA in October 1982 to nearly 1 A today. For the following few years 10 Ahrs of current were delivered most weeks - NSLS now exceeds that every day. (2) When the first experiments were performed on the X-ray ring during FY1985 the electron energy was 2 GeV and the current up to 100 mA - the X-Ray Ring now runs routinely at 2.5 GeV and at 2.8 GeV with up to 350 mA of current, with a very much longer beam half-life and improved reliability. (3) Starting in FY 1984 the proposal for the Phase II upgrade, mainly for a building extension and a suite of insertion devices and their associated beamlines, was pursued - the promises were delivered in full so that for some years now the NSLS has been running with two undulators in the VUV Ring and three wigglers and an undulator in the X-Ray Ring. In addition two novel insertion devices have been commissioned in the X13 straight. (4) At the start of FY 1998 the NSLS welcomed its 7000th user - attracted by the opportunity for pursuing research with high quality beams, guaranteed not to be interrupted by 'delivery failures', and welcomed by an efficient and caring user office and first class teams of PRT and NSLS staff. R & D have lead to the possibility of running the X-Ray Ring at the higher energy of 2.8 GeV. Figure 1 shows the first user beam, which was provided

  11. Physical Activity and Health. A Report of the Surgeon General.

    ERIC Educational Resources Information Center

    President's Council on Physical Fitness and Sports, Washington, DC.

    The informatin in this report summarizes the existing literature on the role of physical activity in preventing disease and on the status of interventions to increase physical activity, focusing on endurance-type physical activity. School-based interventions have been shown to be successful in increasing physical activity levels. With evidence…

  12. Paroxysmal Autonomic Instability With Dystonia Managed Using Chemodenervation Including Alcohol Neurolysis and Botulinum Toxin Type A Injection: A Case Report

    PubMed Central

    Lee, Hye-Sun; Oh, Hyun-Seung

    2015-01-01

    Paroxysmal autonomic instability with dystonia (PAID) is a rare complication of brain injury. Symptoms of PAID include diaphoresis, hyperthermia, hypertension, tachycardia, and tachypnea accompanied by hypertonic movement. Herein, we present the case of a 44-year-old female patient, who was diagnosed with paraneoplastic limbic encephalopathy caused by thyroid papillary cancer. The patient exhibited all the symptoms of PAID. On the basis that the symptoms were unresponsive to antispastic medication and her liver function test was elevated, we performed alcohol neurolysis of the musculocutaneous nerve followed by botulinum toxin type A (BNT-A) injection into the biceps brachii and brachialis. Unstable vital signs and hypertonia were relieved after chemodenervation. Accordingly, alcohol neurolysis and BNT-A injection are proposed as a treatment option for intractable PAID. PMID:25932429

  13. NSLS 2007 Activity Report (National Synchrotron Light Source Activity Report 2007)

    SciTech Connect

    Miller ,L.; Nasta, K.

    2008-05-01

    The National Synchrotron Light Source is one of the world's most productive and cost-effective user facilities. With 2,219 individual users, about 100 more than last year, and a record-high 985 publications, 2007 was no exception. In addition to producing an impressive array of science highlights, which are included in this Activity Report, many NSLS users were honored this year for their scientific accomplishments. Throughout the year, there were major strides in the development of the scientific programs by strengthening strategic partnerships with major research resources and with the Center for Functional Nanomaterials (CFN). Of particular note, the Consortium for Materials Properties Research in Earth Sciences (COMPRES) received renewed funding for the next five years through the National Science Foundation. COMPRES operates four high-pressure NSLS beamlines--X17B2, X17B3, X17C, and U2A--and serves the earth science community as well as the rapidly expanding segment of researchers using high-pressure techniques in materials, chemical, and energy-related sciences. A joint appointment was made between the NSLS and Stony Brook University to further enhance interactions with COMPRES. There was major progress on two key beamline projects outlined in the Five-Year Strategic Plan: the X25 beamline upgrade and the construction of the X9 small angle scattering (SAXS) beamline. The X25 overhaul, which began with the installation of the in-vacuum mini-gap undulator (MGU) in January 2006, is now complete. X25 is once again the brightest beamline for macromolecular crystallography at the NSLS, and in tandem with the X29 undulator beamline, it will keep the NSLS at the cutting edge in this important area of research. Upgrade work associated with the new MGU and the front end for the X9 SAXS beamline--jointly developed by the NSLS and the CFN--also was completed. Beamline X9 will host the SAXS program that currently exists at beamline X21 and will provide new microbeam SAXS

  14. 303-K Storage Facility report on FY98 closure activities

    SciTech Connect

    Adler, J.G.

    1998-07-17

    This report summarizes and evaluates the decontamination activities, sampling activities, and sample analysis performed in support of the closure of the 303-K Storage Facility. The evaluation is based on the validated data included in the data validation package (98-EAP-346) for the 303-K Storage Facility. The results of this evaluation will be used for assessing contamination for the purpose of closing the 303-K Storage Facility as described in the 303-K Storage Facility Closure Plan, DOE/RL-90-04. The closure strategy for the 303-K Storage Facility is to decontaminate the interior of the north half of the 303-K Building to remove known or suspected dangerous waste contamination, to sample the interior concrete and exterior soils for the constituents of concern, and then to perform data analysis, with an evaluation to determine if the closure activities and data meet the closure criteria. The closure criteria for the 303-K Storage Facility is that the concentrations of constituents of concern are not present above the cleanup levels. Based on the evaluation of the decontamination activities, sampling activities, and sample data, determination has been made that the soils at the 303-K Storage Facility meet the cleanup performance standards (WMH 1997) and can be clean closed. The evaluation determined that the 303-K Building cannot be clean closed without additional closure activities. An additional evaluation will be needed to determine the specific activities required to clean close the 303-K Storage Facility. The radiological contamination at the 303-K Storage Facility is not addressed by the closure strategy.

  15. HEPS Inventory Tool: An Inventory Tool Including Quality Assessment of School Interventions on Healthy Eating and Physical Activity

    ERIC Educational Resources Information Center

    Dadaczynski, Kevin; Paulus, Peter; de Vries, Nanne; de Ruiter, Silvia; Buijs, Goof

    2010-01-01

    The HEPS Inventory Tool aims to support stakeholders working in school health promotion to promote high quality interventions on healthy eating and physical activity. As a tool it provides a step-by-step approach on how to develop a national or regional inventory of existing school based interventions on healthy eating and physical activity. It…

  16. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  17. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  18. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  19. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  20. 14 CFR 440.11 - Duration of coverage for licensed launch, including suborbital launch, or permitted activities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... LICENSING FINANCIAL RESPONSIBILITY Financial Responsibility for Licensed and Permitted Activities § 440.11...; modifications. (a) Insurance coverage required under § 440.9, or other form of financial responsibility, shall... licensed launch or permitted activities is sufficiently small that financial responsibility is no...

  1. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  2. Performance of Trasuranic-Loaded Fully Ceramic Micro-Encapsulated Fuel in LWRs Interim Report, Including Void Reactivity Evaluation

    SciTech Connect

    Michael A. Pope; Brian Boer; Gilles Youinou; Abderrafi M. Ougouag

    2011-03-01

    The current focus of the Deep Burn Project is on once-through burning of transuranice (TRU) in light water reactors (LWRs). The fuel form is called Fully-Ceramic Micro-encapsulated (FCM) fuel, a concept that borrows the tri-isotropic (TRISO) fuel particle design from high-temperature reactor technology. In the Deep Burn LWR (DB-LWR) concept, these fuel particles would be pressed into compacts using SiC matrix material and loaded into fuel pins for use in conventional LWRs. The TRU loading comes from the spent fuel of a conventional LWR after 5 years of cooling. Unit cell calculations have been performed using the DRAGON-4 code in order assess the physics attributes of TRU-only FCM fuel in an LWR lattice. Depletion calculations assuming an infinite lattice condition were performed with calculations of various reactivity coefficients performed at each step. Unit cells containing typical UO2 and MOX fuel were analyzed in the same way to provide a baseline against which to compare the TRU-only FCM fuel. Loading of TRU-only FCM fuel into a pin without significant quantities of uranium challenges the design from the standpoint of several key reactivity parameters, particularly void reactivity, and to some degree, the Doppler coefficient. These unit cells, while providing an indication of how a whole core of similar fuel would behave, also provide information of how individual pins of TRU-only FCM fuel would influence the reactivity behavior of a heterogeneous assembly. If these FCM fuel pins are included in a heterogeneous assembly with LEU fuel pins, the overall reactivity behavior would be dominated by the uranium pins while attractive TRU destruction performance of the TRU-only FCM fuel pins may be preserved. A configuration such as this would be similar to CONFU assemblies analyzed in previous studies. Analogous to the plutonium content limits imposed on MOX fuel, some amount of TRU-only FCM pins in an otherwise-uranium fuel assembly may give acceptable reactivity

  3. 24 CFR 81.63 - Annual Housing Activities Report.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Annual Housing Activities Report. 81.63 Section 81.63 Housing and Urban Development Office of the Secretary, Department of Housing and... Annual Housing Activities Report. To comply with the requirements in sections 309(n) of the Fannie...

  4. 24 CFR 81.63 - Annual Housing Activities Report.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Annual Housing Activities Report. 81.63 Section 81.63 Housing and Urban Development Office of the Secretary, Department of Housing and... Annual Housing Activities Report. To comply with the requirements in sections 309(n) of the Fannie...

  5. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  6. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM... activity report by the December 31 after the close of a model year to the Office of Energy Efficiency...

  7. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  8. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  9. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  10. TSCA Chemical Data Reporting Fact Sheet: Reporting Manufactured Chemical Substances from Metal Mining and Related Activities

    EPA Pesticide Factsheets

    This fact sheet provides guidance on the Chemical Data Reporting (CDR) rule requirements related to the reporting of mined metals, intermediates, and byproducts manufactured during metal mining and related activities.

  11. Etiology and Progression of Acute Muscle Tension Related Low Back Pain Occurring During Sustained Activity Including Combat Training Exercises

    DTIC Science & Technology

    1992-01-31

    myelogram consistent with HNP. b. DEGENERATIVE ARTHROSIS , SPONDYLOLYSIS, SPONDYLOLISTHESIS: (1) Radiographic findings consistent with spondylolysis...spondylolisthesis, or degenerative arthritis. This would include facet arthrosis , oseteophyte formation, disc space narrowing, anterior/posterior

  12. Catawba Science Center solar activities. Final report

    SciTech Connect

    1983-01-01

    Two demonstration solar water heaters were built. One was to be used at the Science Center and the other with traveling programs. This was completed and both units are being used for these programs which continue. We were able to build a library of 99 solar energy books and booklets that are available to the public for reference. We also conducted programs for 683 students of all ages. The culminating activity was the planned Energy Awareness Festival. This was held on September 26, 1981 and attracted 450 area citizens. We offered free exhibit space and hosted 17 exhibitors.

  13. High water-stressed population estimated by world water resources assessment including human activities under SRES scenarios

    NASA Astrophysics Data System (ADS)

    Kiguchi, M.; Shen, Y.; Kanae, S.; Oki, T.

    2009-04-01

    In an argument of the reduction and the adaptation for the climate change, the evaluation of the influence by the climate change is important. When we argue in adaptation plan from a damage scale and balance with the cost, it is particularly important. Parry et al (2001) evaluated the risks in shortage of water, malaria, food, the risk of the coast flood by temperature function and clarified the level of critical climate change. According to their evaluation, the population to be affected by the shortage of water suddenly increases in the range where temperature increases from 1.5 to 2.0 degree in 2080s. They showed how much we need to reduce emissions in order to draw-down significantly the number at risk. This evaluation of critical climate change threats and targets of water shortage did not include the water withdrawal divided by water availability. Shen et al (2008a) estimated the water withdrawal of projection of future world water resources according to socio-economic driving factors predicted for scenarios A1b, A2, B1, and B2 of the Special Report on Emission Scenarios (SRES). However, these results were in function of not temperature but time. The assessment of the highly water-stressed population considered the socioeconomic development is necessary for a function of the temperature. Because of it is easy to understand to need to reduce emission. We present a multi-GCM analysis of the global and regional populations lived in highly water-stressed basin for a function of the temperature using the socioeconomic data and the outputs of GCMs. In scenario A2, the population increases gradually with warming. On the other hand, the future projection population in scenario A1b and B1 increase gradually until the temperature anomaly exceeds around from +1 to +1.5 degree. After that the population is almost constant. From Shen et al (2008b), we evaluated the HWSP and its ratio in the world with temperature function for scenarios A1B, A2, and B1 by the index of W

  14. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Schofield, N. J., Jr.; Littlefield, R. G.; Elsen, M. F.

    1985-01-01

    This report provides the professional community with information on current and planned spacecraft activity (including both free-flying spacecraft and Shuttle-attached payloads) for a broad range of scientific disciplines. By providing a brief description of each spacecraft and experiment as well as its current status, it is hoped that this document will be useful to many people interested in the scientific, applied, and operational uses of the data collected. Furthermore, for those investigators who are planning or coordinating future observational programs employing a number of different techniques such as rockets, balloons, aircraft, ships, and buoys, this document can provide some insight into the contributions that may be provided by orbiting instruments. The document includes information concerning active and planned spacecraft and experiments. The information covers a wide range of scientific disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and funding of individual countries, as well as cooperative arrangements among different countries.

  15. Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis

    PubMed Central

    Tiruveedhula, V.V.N. Phani Babu; Witzigmann, Christopher M.; Verma, Ranjit; Kabir, M. Shahjahan; Rott, Marc; Schwan, William R.; Medina-Bielski, Sara; Lane, Michelle; Close, William; Polanowski, Rebecca L.; Sherman, David; Monte, Aaron; Deschamps, Jeffrey R.; Cook, James M.

    2013-01-01

    The alarming increase in bacterial resistance over the last decade along with a dramatic decrease in new treatments for infections has led to problems in the healthcare industry. Tuberculosis (TB) is caused mainly by Mycobacterium tuberculosis which is responsible for 1.4 million deaths per year. A world-wide threat with HIV co-infected with multi and extensively drug-resistant strains of TB has emerged. In this regard, herein, novel acrylic acid ethyl ester derivatives were synthesized in simple, efficient routes and evaluated as potential agents against several Mycobacterium species. These were synthesized via a stereospecific process for structure activity relationship (SAR) studies. Minimum inhibitory concentration (MIC) assays indicated that esters 12, 13, and 20 exhibited greater in vitro activity against Mycobacterium smegmatis than rifampin, one of the current, first-line anti-mycobacterial chemotherapeutic agents. Based on these studies the acrylic ester 20 has been developed as a potential lead compound which was found to have an MIC value of 0.4 μg/mL against Mycobacterium tuberculosis. The SAR and biological activity of this series is presented; a Michael – acceptor mechanism appears to be important for potent activity of this series of analogs. PMID:24200931

  16. Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides.

    PubMed

    Romanova, Elena V; McKay, Natasha; Weiss, Klaudiusz R; Sweedler, Jonathan V; Koester, John

    2007-01-01

    Splice-variant products of the R15 neuropeptide gene are differentially expressed within the CNS of Aplysia. The goal of this study was to test whether the neurons in the abdominal ganglion that express the peptides encoded by this gene are part of a common circuit. Expression of R15 peptides had been demonstrated previously in neuron R15. Using a combination of immunocytochemical and analytical methods, this study demonstrated that R15 peptides are also expressed in heart exciter neuron RB(HE), the two L9(G) gill motoneurons, and L40--a newly identified interneuron. Mass spectrometric profiling of individual neurons that exhibit R15 peptide-like immunoreactivity confirmed the mutually exclusive expression of two splice-variant forms of R15 peptides in different neurons. The L9(G) cells were found to co-express pedal peptide in addition to the R15 peptides. The R15 peptide-expressing neurons examined here were shown to be part of an autonomic control circuit that is active during fictive locomotion. Activity in this circuit contributes to implementing a central command that may help to coordinate autonomic activity with escape locomotion. Chronic extracellular nerve recording was used to determine the activity patterns of a subset of neurons of this circuit in vivo. These results demonstrate the potential utility of using shared patterns of neuropeptide expression as a guide for neural circuit identification.

  17. RILEM TC ISR Summer 2015 Activity Report

    SciTech Connect

    Le Pape, Yann

    2015-08-01

    With aging infrastructures, instances of Alkali Silica Reaction (ASR) and Delayed Ettringite Formation (DEF), broadly covered under the term Internal Swelling Reaction (ISR), are increasingly being detected. They have been observed in bridges, dams, and most recently in nuclear power plants. Concrete swelling may result in bridge partial failure, dams with structural cracks and misaligned turbine shafts, and locked slice gates. For nuclear reactors micro-cracks may cause increased gas permeability which will jeopardize the containment integrity and may decrease the residual structural resistance under accidental loading. This TC, which limits its activity to structures with known expansive concrete, seeks to address two complementary but fundamental questions: a) What is the kinetics of the reaction and b) How would it affect the integrity of the structure (serviceability and strength) and thus establish a science based prognostic to the structure owner.

  18. Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation including Citrus bergamia, in subjects with moderate cardiometabolic risk factors.

    PubMed

    Babish, John G; Dahlberg, Clinton J; Ou, Joseph J; Keller, William J; Gao, Wei; Kaadige, Mohan R; Brabazon, Holly; Lamb, Joseph; Soudah, Hani C; Kou, Xiaolan; Zhang, Zhe; Pacioretty, Linda M; Tripp, Matthew L

    2016-12-01

    We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen. Statistically significant changes were noted in total cholesterol (-7.3%), LDL-cholesterol (-10%), non-HDL cholesterol (-7.1%), cholesterol/HDL (-26%), and apolipoprotein B (-2.8%). A post hoc analysis of 8 subjects with HbA1c > 5.4 and HOMA-IR score > 2 or elevated triglycerides revealed additional statistically significant changes in addition to those previously observed in all subjects including triglycerides (-27%), oxLDL (-19%), LDL/HDL (-25%), triglycerides/HDL (-27%), oxLDL/HDL (-25%), and PAI-1 (-37%). A follow-up case report of a 70-year-old female patient, nonresponsive to statin therapy and placed on F105 daily, demonstrated improved cardiometabolic variables over 12 weeks similar to the subgroup. In summary, F105 was clinically well-tolerated and effective for ameliorating dyslipidemia in subjects with moderate cardiometabolic risk factors, particularly in the individuals with HbA1c > 5.4%.

  19. Advanced Light Source: Activity report 1993

    SciTech Connect

    Not Available

    1994-11-01

    The Advanced Light Source (ALS) produces the world`s brightest light in the ultraviolet and soft x-ray regions of the spectrum. The first low-energy third-generation synchrotron source in the world, the ALS provides unprecedented opportunities for research in science and technology not possible anywhere else. This year marked the beginning of operations and the start of the user research program at the ALS, which has already produced numerous high quality results. A national user facility located at Lawrence Berkeley Laboratory of the University of California, the ALS is available to researchers from academia, industry, and government laboratories. This report contains the following: (1) director`s message; (2) operations overview; (3) user program; (4) users` executive committee; (5) industrial outreach; (6) accelerator operations; (7) beamline control system; (8) insertion devices; (9) experimental systems; (10) beamline engineering; (11) first results from user beamlines; (12) beamlines for 1994--1995; (13) special events; (14) publications; (15) advisory panels; and (16) ALS staff.

  20. Robotics at Savannah River site: activity report

    SciTech Connect

    Byrd, J.S.

    1984-09-01

    The objectives of the Robotics Technology Group at the Savannah River Laboratory are to employ modern industrial robots and to develop unique automation and robotic systems to enhance process operations at the Savannah River site (SRP and SRL). The incentives are to improve safety, reduce personnel radiation exposure, improve product quality and productivity, and to reduce operating costs. During the past year robotic systems have been installed to fill chemical dilution vials in a SRP laboratory at 772-F and remove radioactive waste materials in the SRL Californium Production Facility at 773-A. A robotic system to lubricate an extrusion press has been developed and demonstrated in the SRL robotics laboratory and is scheduled for installation at the 321-M fuel fabrication area. A mobile robot was employed by SRP for a radiation monitoring task at a waste tank top in H-Area. Several other robots are installed in the SRL robotics laboratories and application development programs are underway. The status of these applications is presented in this report.

  1. Severe Accident Test Station Activity Report

    SciTech Connect

    Pint, Bruce A.; Terrani, Kurt A.

    2015-06-01

    Enhancing safety margins in light water reactor (LWR) severe accidents is currently the focus of a number of international R&D programs. The current UO2/Zr-based alloy fuel system is particularly susceptible since the Zr-based cladding experiences rapid oxidation kinetics in steam at elevated temperatures. Therefore, alternative cladding materials that offer slower oxidation kinetics and a smaller enthalpy of oxidation can significantly reduce the rate of heat and hydrogen generation in the core during a coolant-limited severe accident. In the U.S. program, the high temperature steam oxidation performance of accident tolerant fuel (ATF) cladding solutions has been evaluated in the Severe Accident Test Station (SATS) at Oak Ridge National Laboratory (ORNL) since 2012. This report summarizes the capabilities of the SATS and provides an overview of the oxidation kinetics of several candidate cladding materials. A suggested baseline for evaluating ATF candidates is a two order of magnitude reduction in the steam oxidation resistance above 1000ºC compared to Zr-based alloys. The ATF candidates are categorized based on the protective external oxide or scale that forms during exposure to steam at high temperature: chromia, alumina, and silica. Comparisons are made to literature and SATS data for Zr-based alloys and other less-protective materials.

  2. An Intramolecular Silylene Borane Capable of Facile Activation of Small Molecules, Including Metal-Free Dehydrogenation of Water.

    PubMed

    Mo, Zhenbo; Szilvási, Tibor; Zhou, Yu-Peng; Yao, Shenglai; Driess, Matthias

    2017-02-27

    The first single-component N-heterocyclic silylene borane 1 (LSi-R-BMes2 ; L=PhC(N(t) Bu)2 ; R=1,12-xanthendiyl spacer; Mes=2,4,6-Me3 C6 H2 ), acting as a frustrated Lewis pair (FLP) in small-molecule activation, can be synthesized in 65 % yields. Its HOMO is largely localized at the silicon(II) atom and the LUMO has mainly boron 2p character. In small-molecule activation 1 allows access to the intramolecular silanone-borane 3 featuring a Si=O→B interaction through reaction with O2 , N2 O, or CO2 , and formation of silanethione borane 4 from reaction with S8 . The Si(II) center in 1 undergoes immediate hydrogenation if exposed to H2 at 1 atm pressure in benzene, affording the silane borane 5-H2 , L(H2 )Si-R-BMes2 . Remarkably, no H2 activation occurs if the single silylene LSiPh and Mes3 B intermolecularly separated are exposed to dihydrogen. Unexpectedly, the pre-organized Si-B separation in 1 enables a metal-free dehydrogenation of H2 O to give the silanone-borane 3 as reactive intermediate.

  3. Eighteenth annual report of the United States Geological Survey to the Secretary of the Interior, 1896-1897: Part I - Director's report, including triangulation and spirit leveling

    USGS Publications Warehouse

    Walcott, Charles D.

    1897-01-01

    The most important change in the field work was rendered necessary by the legislation providing for the establishment of levels and permanent monuments and bench marks. The clauses of the act embodying this legislation, and a full statement of the reasons for it, were given in the Introduction to Part I of the Seventeenth Annual Report, pages 7 to 11, and the subject is again referred to further on in this report. The actual cost of the leveling and monuments for the year was somewhat greater than it will be another year, as the expense of training men and initiating the new methods- of survey will not have to be met hereafter. During the year 10,840 miles of levels were run and 1,820 bench marks were established.

  4. Hydrogen storage on activated carbon. Final report

    SciTech Connect

    Schwarz, J.A.

    1994-11-01

    The project studied factors that influence the ability of carbon to store hydrogen and developed techniques to enhance that ability in naturally occurring and factory-produced commercial carbon materials. During testing of enhanced materials, levels of hydrogen storage were achieved that compare well with conventional forms of energy storage, including lead-acid batteries, gasoline, and diesel fuel. Using the best materials, an electric car with a modern fuel cell to convert the hydrogen directly to electricity would have a range of over 1,000 miles. This assumes that the total allowable weight of the fuel cell and carbon/hydrogen storage system is no greater than the present weight of batteries in an existing electric vehicle. By comparison, gasoline cars generally are limited to about a 450-mile range, and battery-electric cars to 40 to 60 miles. The project also developed a new class of carbon materials, based on polymers and other organic compounds, in which the best hydrogen-storing factors discovered earlier were {open_quotes}molecularly engineered{close_quotes} into the new materials. It is believed that these new molecularly engineered materials are likely to exceed the performance of the naturally occurring and manufactured carbons seen earlier with respect to hydrogen storage.

  5. Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress.

    PubMed

    Morita, Reiko; Yafune, Atsunori; Shiraki, Ayako; Itahashi, Megu; Ishii, Yuji; Akane, Hirotoshi; Nakane, Fumiyuki; Suzuki, Kazuhiko; Shibutani, Makoto; Mitsumori, Kunitoshi

    2013-01-01

    Orphenadrine (ORPH), an anticholinergic agent, is a cytochrome P450 (CYP) 2B inducer. CYP2B inducers are known to have liver tumor-promoting effects in rats. In this study, we performed a rat two-stage liver carcinogenesis bioassay to examine the tumor-promoting effect of ORPH and to clarify its possible mechanism of action. Male rats were given a single intraperitoneal injection of N-diethylnitrosamine (DEN) as an initiation treatment. Two weeks after DEN administration, rats were fed a diet containing ORPH (0, 750, or 1,500 ppm) for 6 weeks. One week after the ORPH-administration rats were subjected to two-thirds partial hepatectomy for the acceleration of hepatocellular proliferation. The number and area of glutathione S-transferase placental form-positive foci significantly increased in the DEN-ORPH groups. Real-time RT-PCR revealed increased mRNA expression levels of Cyp2b1/2, Mrp2 and Cyclin D1 in the DEN-ORPH groups and of Gpx2 and Gstm3 in the DEN-High ORPH group. Microsomal reactive oxygen species (ROS) production and oxidative stress markers such as thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine were increased in the DEN-High ORPH group. Immunohistochemically, constitutively active/androstane receptor (CAR) were clearly localized in the nuclei of hepatocytes in the DEN-ORPH groups. These results suggest that ORPH causes nuclear translocation of CAR resulting in the induction of the liver tumor-promoting activity. Furthermore, oxidative stress resulting from ROS production is also involved in the liver tumor-promoting activity of ORPH.

  6. Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine.

    PubMed

    Theys, K; Camacho, R J; Gomes, P; Vandamme, A M; Rhee, S Y

    2015-06-01

    Rilpivirine is a second-generation nonnucleoside reverse-transcriptase inhibitor (NNRTI) currently indicated for first-line therapy, but its clinical benefit for HIV-1 infected patients failing first-generation NNRTIs is largely undefined. This study quantified the extent of genotypic rilpivirine resistance in viral isolates from 1212 patients upon failure of efavirenz- or nevirapine-containing antiretroviral treatment, of whom more than respectively 80% and 90% showed high-level genotypic resistance to the failing NNRTI. Of all study patients, 47% showed a rilpivirine resistance-associated mutation (RPV-RAM), whereas preserved residual rilpivirine activity was predicted in half of the patients by three genotypic drug resistance interpretation algorithms. An NNRTI-dependent impact on rilpivirine resistance was detected. Compared with the use of nevirapine, the use of efavirenz was associated with a 32% lower risk of having a RPV-RAM and a 50% lower risk of predicted reduced rilpivirine susceptibility. Most prevalent RPV-RAMs after nevirapine experience were Y181C and H221Y, whereas L100I+K103N, Y188L and K101E occurred most in efavirenz-experienced patients. Predicted rilpivirine activity was not affected by HIV-1 subtype, although frequency of individual mutations differed across subtypes. In conclusion, this genotypic resistance analysis strongly suggests that the latest NNRTI, rilpivirine, may retain activity in a large proportion of HIV-1 patients in whom resistance failed while they were on an efavirenz- or nevirapine-containing regimen, and may present an attractive option for second-line treatment given its good safety profile and dosing convenience. However, prospective clinical studies assessing the effectiveness of rilpivirine for NNRTI-experienced patients are warranted to validate knowledge derived from genotypic and phenotypic drug resistance studies.

  7. Reported frequency of physical activity in a large epidemiological study: relationship to specific activities and repeatability over time

    PubMed Central

    2011-01-01

    Background How overall physical activity relates to specific activities and how reported activity changes over time may influence interpretation of observed associations between physical activity and health. We examine the relationships between various physical activities self-reported at different times in a large cohort study of middle-aged UK women. Methods At recruitment, Million Women Study participants completed a baseline questionnaire including questions on frequency of strenuous and of any physical activity. About 3 years later 589,896 women also completed a follow-up questionnaire reporting the hours they spent on a range of specific activities. Time spent on each activity was used to estimate the associated excess metabolic equivalent hours (MET-hours) and this value was compared across categories of physical activity reported at recruitment. Additionally, 18,655 women completed the baseline questionnaire twice, at intervals of up to 4 years; repeatability over time was assessed using the weighted kappa coefficient (κweighted) and absolute percentage agreement. Results The average number of hours per week women reported doing specific activities was 14.0 for housework, 4.5 for walking, 3.0 for gardening, 0.2 for cycling, and 1.4 for all strenuous activity. Time spent and the estimated excess MET-hours associated with each activity increased with increasing frequency of any or strenuous physical activity reported at baseline (tests for trend, P < 0.003), although the associations for housework were by far the weakest (Spearman correlations, 0.01 and -0.03 respectively for housework, and 0.11-0.37 for all other activities). Repeatability of responses to physical activity questions on the baseline questionnaire declined significantly over time. For strenuous activity, absolute agreement was 64% (κweighted = 0.71) for questionnaires administered less than 6 months apart, and 52% (κweighted = 0.51) for questionnaires more than 2 years apart. Corresponding

  8. The Influence of Organized Physical Activity (Including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed

    Bernardoni, Brittney; Scerpella, Tamara A; Rosenbaum, Paula F; Kanaley, Jill A; Raab, Lindsay N; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N

    2015-05-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semiannual records of anthropometry, maturity, and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year premenarche [predictor] and ~5 years postmenarche [dependent variable]). Regression analysis evaluated total adolescent interscan PA and PA over 3 maturity subphases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry, and strength indices at nondominant distal radius and femoral neck; 2) subhead BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or postmenarche), baseline bone status, adult body size and interscan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p > .07). Premenarcheal bone traits were strong predictors of most adult outcomes (semipartial r2 = .21-0.59, p ≤ .001). Adult 1/3 radius and subhead BMC were predicted by both total PA and PA 1-3 years postmenarche (p < .03). PA 3-5 years postmenarche predicted femoral narrow neck width, endosteal diameter, and buckling ratio (p < .05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females.

  9. The Influence of Organized Physical Activity (including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed Central

    Bernardoni, Brittney; Scerpella, Tamara A.; Rosenbaum, Paula F.; Kanaley, Jill A.; Raab, Lindsay N.; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N.

    2015-01-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semi-annual records of anthropometry, maturity and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year pre-menarche [predictor] and ~5 years post-menarche [dependent variable]). Regression analysis evaluated total adolescent inter-scan PA and PA over 3 maturity sub-phases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry and strength indices at non-dominant distal radius and femoral neck; 2) sub-head BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or post-menarche), baseline bone status, adult body size and inter-scan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p<0.07). Pre-menarcheal bone traits were strong predictors of most adult outcomes (semi-partial r2 = 0.21-0.59, p≤0.001). Adult 1/3 radius and sub-head BMC were predicted by both total PA and PA 1-3 years post-menarche (p<0.03). PA 3-5 years post-menarche predicted femoral narrow neck width, endosteal diameter and buckling ratio (p<0.05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females. PMID:25386845

  10. Despite 2007 law requiring FDA hotline to be included in print drug ads, reporting of adverse events by consumers still low.

    PubMed

    Du, Dongyi; Goldsmith, John; Aikin, Kathryn J; Encinosa, William E; Nardinelli, Clark

    2012-05-01

    In 2007 the federal government began requiring drug makers to include in their print direct-to-consumer advertisements information for consumers on how to contact the Food and Drug Administration directly, either by phone or through the agency's website, to report any adverse events that they experienced after taking a prescription drug. Adverse events can range from minor skin problems like itching to serious injuries or illness that result in hospitalization, permanent disability, or even death. Even so, current rates of adverse event reporting are low. We studied adverse event reports about 123 drugs that came from patients before and after the enactment of the print advertising requirement and estimated that requirement's impact with model simulations. We found that if monthly spending on print direct-to-consumer advertising increased from zero to $7.7 million per drug, the presence of the Food and Drug Administration contact information tripled the increase in patient-reported adverse events, compared to what would have happened in the absence of the law. However, the absolute monthly increase was fewer than 0.24 reports per drug, suggesting that the public health impact of the increase was small and that the adverse event reporting rate would still be low. The study results suggest that additional measures, such as more publicity about the Adverse Event Reporting System or more consumer education, should be considered to promote patient reporting of adverse events.

  11. Environmental Activities for Teaching Critical Thinking. [Environmental Education Information Report.

    ERIC Educational Resources Information Center

    Howe, Robert W.; Disinger, John F.

    The ability to think critically is essential if individuals are to live, work, and function effectively in our current and changing society. The activities included in this publication were selected to identify a variety of effective strategies for teaching critical thinking skills through environmental education. Activities include library…

  12. Space shuttle orbiter avionics software: Post review report for the entry FACI (First Article Configuration Inspection). [including orbital flight tests integrated system

    NASA Technical Reports Server (NTRS)

    Markos, H.

    1978-01-01

    Status of the computer programs dealing with space shuttle orbiter avionics is reported. Specific topics covered include: delivery status; SSW software; SM software; DL software; GNC software; level 3/4 testing; level 5 testing; performance analysis, SDL readiness for entry first article configuration inspection; and verification assessment.

  13. New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

    PubMed

    La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

    2014-08-14

    We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro the Hedgehog signaling pathway, strongly reducing luciferase activity in SAG treated NIH3T3 Shh-Light II cells, and inhibited the growth of medulloblastoma D283 cells at nanomolar concentrations. ARAPs 22 and 27 represent a new potent class of tubulin polymerization and cancer cell growth inhibitors with the potential to inhibit the Hedgehog signaling pathway.

  14. New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

    PubMed Central

    La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

    2014-01-01

    We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro the Hedgehog signaling pathway, strongly reducing luciferase activity in SAG treated NIH3T3 Shh-Light II cells, and inhibited the growth of medulloblastoma D283 cells at nanomolar concentrations. ARAPs 22 and 27 represent a new potent class of tubulin polymerization and cancer cell growth inhibitors with the potential to inhibit the Hedgehog signaling pathway. PMID:25025991

  15. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... § 1710.310 Annual report of activity. (a) As an integral part of the Statement of Record, the developer... by the senior executive officer of the developer on a signature line above his typed name and...

  16. NASA's Microgravity Technology Report: Summary of Activities 1997

    NASA Technical Reports Server (NTRS)

    Woodard, Dan

    1998-01-01

    The purpose of the 1997 NASA Microgravity Technology Report is to update the Microgravity Research Program's technology development policy and to present and assess current technology related activities and requirements identified within its research and technology disciplines.

  17. Aeronautics and Space Report of the President: Fiscal Year 2007 Activities

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2006, through September 30, 2007.

  18. Aeronautics and Space Report of the President: Fiscal Year 1999 Activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1998, through September 30, 1999.

  19. Aeronautics and Space Report of the President: Fiscal Year 2001 Activities

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a 'comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year.' In recent years the reports have been prepared on a fiscal-year basis consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2000, through September 30, 2001.

  20. Aeronautics and Space Report of the President: Fiscal Year 2000 Activities

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1999, through September 30, 2000.

  1. Aeronautics and Space Report of the President: Fiscal Year 2005 Activities

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1 , 2004, through September 30, 2005.

  2. Aeronautics and Space Report of the President: Fiscal Year 2003 Activities

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year. In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2002, through September 30, 2003.

  3. Aeronautics and Space Report of the President - Fiscal Year 2010 Activities

    NASA Technical Reports Server (NTRS)

    2011-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2009, through September 30, 2010.

  4. Aeronautics and Space Report of the President - Fiscal Year 2008 Activities

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2007, through September 30, 2008.

  5. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Periodic reports. Each savings association and service corporation thereof shall make such periodic or... may provide that reports filed by savings associations or service corporations to meet the... savings associations and service corporations file a Suspicious Activity Report when they detect a...

  6. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.

  7. NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 10: Summary report to phase 3 academic library respondents including frequency distributions

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 3 of a 4 part study was undertaken to study the use of scientific and technical information (STI) in the academic aerospace community. Phase 3 of this project used three questionnaires that were sent to three groups (i.e., faculty, librarians, and students) in the academic aerospace community. Specific attention was paid to the types of STI used and the methods in which academic users acquire STI. The responses of the academic libraries are focussed on herein. Demographic information on academic aerospace libraries is provided. Data regarding NASA interaction with academic aerospace libraries is also included, as is the survey instrument.

  8. 105-DR Large Sodium Fire Facility closure activities evaluation report

    SciTech Connect

    Adler, J.G.

    1996-04-11

    This report evaluates the closure activities at the 105-DR Large Sodium Fire Facility. The evaluation compares these activities to the regulatory requirements and closure plan requirements. The report concludes that the areas identified in the closure plan can be clean closed. This report summarizes and evaluates the closure activities performed in support of partial closure of the 105-DR Large Sodium Fire Facility (LSFF). This evaluation will be used in assessing the condition of the 105-DR LSFF for the purpose of meeting the partial clean closure conditions described in the 105-DR Large Sodium Fire Facility Closure Plan (DOE-RL 1995). Based on the evaluation of the decontamination activities, sampling activities, and sample data, it is has been determined that the partial clean closure conditions for the 105-DR LSFF have been met.

  9. A Tunable, Modular Approach to Fluorescent Protease-Activated Reporters

    PubMed Central

    Wu, Peng; Nicholls, Samantha B.; Hardy, Jeanne A.

    2013-01-01

    Proteases are one of the most important and historically utilized classes of drug targets. To effectively interrogate this class of proteins, which encodes nearly 2% of the human proteome, it is necessary to develop effective and cost-efficient methods that report on their activity both in vitro and in vivo. We have developed a robust reporter of caspase proteolytic activity, called caspase-activatable green fluorescent protein (CA-GFP). The caspases play central roles in homeostatic regulation, as they execute programmed cell death, and in drug design, as caspases are involved in diseases ranging from cancer to neurodegeneration. CA-GFP is a genetically encoded dark-to-bright fluorescent reporter of caspase activity in in vitro, cell-based, and animal systems. Based on the CA-GFP platform, we developed reporters that can discriminate the activities of caspase-6 and -7, two highly related proteases. A second series of reporters, activated by human rhinovirus 3C protease, demonstrated that we could alter the specificity of the reporter by reengineering the protease recognition sequence. Finally, we took advantage of the spectrum of known fluorescent proteins to generate green, yellow, cyan, and red reporters, paving the way for multiplex protease monitoring. PMID:23561537

  10. A comparison of methods of assessment of body composition including neutron activation analysis of total body nitrogen.

    PubMed

    Lukaski, H C; Mendez, J; Buskirk, E R; Cohn, S H

    1981-08-01

    Fourteen healthy men underwent determinations of total body nitrogen (TBN) by prompt gamma neutron activation analysis and total body potassium (TBK) by whole body counting to estimate the muscle and nonmuscle components of the fat-free body mass (FFBM) and their protein contents. Comparison of FFBM estimated from TBN and TBK (60.6 +/- 6.9 kg, mean +/- SD), densitometry (62.3 +/- 7.1 kg), TBK alone (62.2 +/- 8.0 kg) and TBW (63.9 +/- 7.8 kg) showed no differences among the techniques. Similarly, there were neither differences in fat mass nor percent body fat among the methods. Analysis of the chemical composition of FFBM of this group showed TBK/FFBM = 62.6 +/- 2.3 mEq/kg, TBW/FFBM = 74.6 +/- 0.2%, TBN/FFBM = 32.74 +/- 1.09 g/kg, protein/FFBM = 20.5+/- 0.7%. The calculated mineral content of the FFBM was 6.4%. These values are strikingly similar to the values calculated by direct chemical analysis. It was concluded that the combined TBN-TBK method is a valid technique for estimating body composition in man.

  11. Product and rate determinations with chemically activated nucleotides in the presence of various prebiotic materials, including other mono- and polynucleotides

    NASA Technical Reports Server (NTRS)

    Kanavarioti, A.; Alberas, D. J.; Rosenbach, M. T.; Bernasconi, C. F.; Chang, S.

    1991-01-01

    We are investigating the reactions of ImpN's in the presence of a number of prebiotically plausible materials, such as metal ions, phosphate, amines and other nucleotides and hope to learn more about the stability/reactivity of ImpN's in a prebiotic aqueous environment. We find that, in the presence of phosphate, ImpN's form substantial amounts of diphosphate nucleotides. These diphosphate nucleotides are not very good substrates for template directed reactions, but are chemically activated and are known to revert to the phosphoimidazolides in the presence of imidazole under solid state conditions. With respect to our studies of the oligomerization reaction, the determination of the dimerization rate constant of a specific ImpN (guanosine 5'-phospho 2 methylimidazolide) both in the absence and the presence of the template leads to the conclusion that at 37 C the dimerization is not template directed, although the subsequent polymerization steps are. In other words, this specific polynucleotide synthesizing system favors the elongation of oligonucleotides as compared with the formation of dimers and trimers. This favoring of the synthesis of long as opposed to short oligonucleotides may be regarded as a rudimentary example of natural selection at the molecular level.

  12. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Annual report of activity. 1710.310 Section 1710.310 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting...

  13. Advanced Light Source Activity Report 1997/1998

    SciTech Connect

    Greiner, Annette

    1999-03-01

    This Lawrence Berkeley National Laboratory, Advanced Light Source (ALS) activity report for 1997/98 discusses the following topics: Introduction and Overview; Science Highlights; Facility Report; Special Events; ALS Advisory Panels 1997/98; ALS Staff 1997/98 and Facts and Figures for the year.

  14. A Self-Report Measure of Physical Activity

    ERIC Educational Resources Information Center

    Siegel, Donald

    2005-01-01

    There are multiple approaches to measuring physical activity. Among these are direct observation, electronic monitoring, direct and indirect calorimetry, and self-report instruments. Self-report instruments are the most practical and cost effective option for use with a large group. In a study by Motl, Dishman, Dowda, and Pate (2004), two groups…

  15. Section on Cataloguing: Report of the Activities, 1998/1999.

    ERIC Educational Resources Information Center

    Witt, Maria

    This paper reports on the activities of the International Federation of Library Associations and Institutions (IFLA) Section on Cataloguing for 1998-99. The first part of the report introduces the aims of the Section. Membership, the standing committee, and officers are detailed in the second part. The third part provides information on the…

  16. RELAP-7 Progress Report. FY-2015 Optimization Activities Summary

    SciTech Connect

    Berry, Ray Alden; Zou, Ling; Andrs, David

    2015-09-01

    This report summarily documents the optimization activities on RELAP-7 for FY-2015. It includes the migration from the analytical stiffened gas equation of state for both the vapor and liquid phases to accurate and efficient property evaluations for both equilibrium and metastable (nonequilibrium) states using the Spline-Based Table Look-up (SBTL) method with the IAPWS-95 properties for steam and water. It also includes the initiation of realistic closure models based, where appropriate, on the U.S. Nuclear Regulatory Commission’s TRACE code. It also describes an improved entropy viscosity numerical stabilization method for the nonequilibrium two-phase flow model of RELAP-7. For ease of presentation to the reader, the nonequilibrium two-phase flow model used in RELAP-7 is briefly presented, though for detailed explanation the reader is referred to RELAP-7 Theory Manual [R.A. Berry, J.W. Peterson, H. Zhang, R.C. Martineau, H. Zhao, L. Zou, D. Andrs, “RELAP-7 Theory Manual,” Idaho National Laboratory INL/EXT-14-31366(rev. 1), February 2014].

  17. Active Coping Reduces Reports of Pain from Childbirth.

    ERIC Educational Resources Information Center

    Leventhal, Elaine A.; And Others

    1989-01-01

    Examined pain and negative moods during labor in relation to instructions to monitor labor contractions and LaMaze class attendance. In Study 1, pain and negative moods showed sharp decline at Stage 2 (active labor) for women who monitored and LaMaze participants; in Study 2, LaMaze participants reported decline in pain during active labor and…

  18. Report of National Collegiate Alcohol Awareness Week Activities Fall 1987.

    ERIC Educational Resources Information Center

    Owens, Ann English; And Others

    This document presents a report of the education and prevention activities recognizing National Collegiate Alcohol Awareness (NCAA) Week undertaken at Central Michigan University in Mt. Pleasant, Michigan during October and early November, 1987. It begins with a brief review of the university's campus-wide programs, goals, and activities to reduce…

  19. Aeronautics and Space Report of the President: 1975 Activities.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This report, submitted to the Congress by President Ford in accordance with the National Aeronautics and Space Act of 1958, summarizes the United States' space and aeronautics activities for the year 1975. Detailed summaries of the activities of the following governmental departments or agencies are provided: National Aeronautics and Space…

  20. Worksite Health Promotion Activities. 1992 National Survey. Summary Report.

    ERIC Educational Resources Information Center

    Public Health Service (DHHS), Rockville, MD. Office of Disease Prevention and Health Promotion.

    The survey reported in this document examined worksite health promotion and disease prevention activities in 1,507 private worksites in the United States. Specificlly, the survey assessed policies, practices, services, facilities, information, and activities sponsored by employers to improve the health of their employees, and assessed health…

  1. HYDRODYNAMIC MODELS FOR SLURRY BUBBLE COLUMN REACTORS. FINAL TECHNICAL REPORT ALSO INCLUDES THE QUARTERLY TECHNICAL REPORT FOR THE PERIOD 01/01/1997 - 03/31/1997.

    SciTech Connect

    DIMITRI GIDASPOW

    1997-08-15

    The objective of this study is to develop a predictive experimentally verified computational fluid dynamic (CFD) three phase model. It predicts the gas, liquid and solid hold-ups (volume fractions) and flow patterns in the industrially important bubble-coalesced (churn-turbulent) regime. The input into the model can be either particulate viscosities as measured with a Brookfield viscometer or effective restitution coefficient for particles. A combination of x-ray and {gamma}-ray densitometers was used to measure solid and liquid volume fractions. There is a fair agreement between the theory and the experiment. A CCD camera was used to measure instantaneous particle velocities. There is a good agreement between the computed time average velocities and the measurements. There is an excellent agreement between the viscosity of 800 {micro}m glass beads obtained from measurement of granular temperature (random kinetic energy of particles) and the measurement using a Brookfield viscometer. A relation between particle Reynolds stresses and granular temperature was found for developed flow. Such measurement and computations gave a restitution coefficient for a methanol catalyst to be about 0.9. A transient, two-dimensional hydrodynamic model for production of methanol from syn-gas in an Air Products/DOE LaPorte slurry bubble column reactor was developed. The model predicts downflow of catalyst at the walls and oscillatory particle and gas flow at the center, with a frequency of about 0.7 Hertz. The computed temperature variation in the rector with heat exchangers was only about 5 K, indicating good thermal management. The computed slurry height, the gas holdup and the rate of methanol production agree with LaPorte's reported data. Unlike the previous models in the literature, this model computes the gas and the particle holdups and the particle rheology. The only adjustable parameter in the model is the effective particle restitution coefficient.

  2. Effect of the Heat-exposure on Peripheral Sudomotor Activity Including the Density of Active Sweat Glands and Single Sweat Gland Output.

    PubMed

    Lee, Jeong-Beom; Kim, Tae-Wook; Shin, Young-Oh; Min, Young-Ki; Yang, Hun-Mo

    2010-10-01

    Tropical inhabitants are able to tolerate heat through permanent residence in hot and often humid tropical climates. The goal of this study was to clarify the peripheral mechanisms involved in thermal sweating pre and post exposure (heat-acclimatization over 10 days) by studying the sweating responses to acetylcholine (ACh), a primary neurotransmitter of sudomotor activity, in healthy subjects (n=12). Ten percent ACh was administered on the inner forearm skin for iontophoresis. Quantitative sudomotor axon reflex testing, after iontophoresis (2 mA for 5 min) with ACH, was performed to determine directly activated (DIR) and axon reflex-mediated (AXR) sweating during ACh iontophoresis. The sweat rate, activated sweat gland density, sweat gland output per single gland activated, as well as oral and skin temperature changes were measured. The post exposure activity had a short onset time (p<0.01), higher active sweat rate [(AXR (p<0.001) and DIR (p<0.001)], higher sweat output per gland (p<0.001) and higher transepidermal water loss (p<0.001) compared to the pre-exposure measurements. The activated sweat rate in the sudomotor activity increased the output for post-exposure compared to the pre-exposure measurements. The results suggested that post-exposure activity showed a higher active sweat gland output due to the combination of a higher AXR (DIR) sweat rate and a shorter onset time. Therefore, higher sudomotor responses to ACh receptors indicate accelerated sympathetic nerve responsiveness to ACh sensitivity by exposure to environmental conditions.

  3. Seven-day activity and self-report compared to a direct measure of physical activity.

    PubMed

    Taylor, C B; Coffey, T; Berra, K; Iaffaldano, R; Casey, K; Haskell, W L

    1984-12-01

    To determine how well a seven-day interview-administered activity recall used in a large epidemiologic study at Stanford University reflected seven days of self-reported activity and directly measured physical activity, 30 white males, mean age 52 years, recorded daily physical activity for a week, and half of these wore an ambulatory solid-state minicomputer (Vitalog) which measures continuous heart rate and motion. Total hours of moderate, hard, and hard plus very hard activity were not significantly different for weekdays and weekends for self-report and recall and were significantly correlated. Total energy expenditure for subjects wearing the Vitalog averaged 38.5 +/- 6.7 kcal/kg/day compared to an average of 37.7 +/- 4.5 kcal/kg/day for recall or 39.6 +/- 7.2 kcal/kg/day for self-report. Conditioning activities are best remembered followed by home or leisure and job activities. Mean hours of sleep per week night were significantly greater reported by self-report than reported by recall, but the two were significantly correlated. It is concluded that a seven-day activity recall accurately reflects mean kcal/day expenditure, with conditioning activities being the best recalled. A self-report log used in conjunction with an interview-based seven-day recall might maximize accuracy of recall.

  4. Report on the CEPA activities [Consorcio Educativo para la Proteccion Ambiental/Educational Consortium for Environmental Preservation] [Final report of activities from 1998 to 2002

    SciTech Connect

    Cruz, Miriam

    2003-02-01

    This report compiles the instances of scientific, educational, and institutional cooperation on environmental issues and other activities in which CEPA was engaged during the past five years, and includes several annual reports and meeting summaries. CEPA is a collaborative international consortium that brings together higher education institutions with governmental agencies, research laboratories, and private sector entities. CEPA's mission is to strengthen the technical, professional, and educational environmental infrastructure in the United States and Latin America. The CEPA program includes curriculum development, student exchange, faculty development, and creation of educational materials, joint research, and other cooperative activities. CEPA's goals are accomplished by actively working with Hispanic-serving institutions of higher education in the United States, in collaboration with institutions of higher education in Latin America and other Consortium members to deliver competitive environmental programs.

  5. High energy physics division semiannual report of research activities

    SciTech Connect

    Schoessow, P.; Moonier, P.; Talaga, R.; Wagner, R. )

    1991-08-01

    This report describes the research conducted in the High Energy Physics Division of Argonne National Laboratory during the period of January 1, 1991--June 30, 1991. Topics covered here include experimental and theoretical particle physics, advanced accelerator physics, detector development, and experimental facilities research. Lists of division publications and colloquia are included.

  6. NSLS 2006 ACTIVITY REPORT (NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 2006)

    SciTech Connect

    MILLER, L.

    2006-12-31

    and the years to follow, we need to continue to educate our elected representatives about the benefits that are provided to our society and our economy by scientific investigation including research done at DOE user facilities like the NSLS. We face another interesting challenge as the NSLS-II project progresses: the formation of scientific research teams associated with particular beamlines at the new facility. In early 2007, the final draft of the conceptual design report will be available, which will describe the projected capabilities of NSLS-II, and we can expect a workshop in mid-2007 to launch the process leading to letters of intent for beamlines. This process will include lots of discussion about access modes, as we seek ways to allow scientific and technical innovators from the user community to play significant roles at NSLS-II.

  7. Surveillance report for active trachoma, 2006: National Trachoma Surveillance and Reporting Unit.

    PubMed

    Tellis, Betty; Keeffe, Jill E; Taylor, Hugh R

    2007-12-01

    The National Trachoma Surveillance and Reporting Unit (NTSRU) was established in November 2006 to improve the quality and consistency of data collection and reporting of active trachoma in Australia. Active trachoma data collected in 2006, prior to the commencement of the NTSRU, were reported by the Northern Territory, South Australia and Western Australia. In most regions, Aboriginal children aged 5-9 years were screened for signs of active trachoma, following the World Health Organization simplified trachoma grading system. In the Northern Territory the Healthy School Aged Kids program conducted school-based screening for active trachoma in 74 schools in five regions (n = 2,253). In South Australia Aboriginal school children presented for active trachoma screening when an eye team visited five Aboriginal Community Controlled Health Services (n = 275). In Western Australia population health units in collaboration with staff from population health care services, conducted school based screening for active trachoma in 53 schools in four regions (n = 1,719). Regional active trachoma prevalence for 2006 varied between the states and the Northern Territory with reported prevalences ranging from: Northern Territory = 2.5%-30%, South Australia = 0%-25%, and Western Australia = 18%-53%. Few data were reported on facial cleanliness or other aspects of the SAFE strategy, and no data were reported for trichiasis.

  8. Junior High Career Maturity Activities. Report No. 33-A-57.

    ERIC Educational Resources Information Center

    Afdahl, Anne; And Others

    The activities in this curriculum guide are designed to facilitate self-evaluation, goal setting, and educator-student planning of junior high learning experiences relating to career maturity. It is suggested that the career maturity measurement activity worksheets can be included in the student's school record and used as a reference base for…

  9. Senior High Career Maturity Activities. Report No. 33-A-58.

    ERIC Educational Resources Information Center

    Bauman, Virginia; And Others

    The activities in this curriculum guide are designed to facilitate self-evaluation, goal setting, and educator-student planning of learning experiences relating to career maturity. It is suggested that the career maturity measurement activity worksheets can be included in the student's school record and used as a reference base for future…

  10. Towards a new paradigm: Activity level balanced sustainability reporting.

    PubMed

    Samudhram, Ananda; Siew, Eu-Gene; Sinnakkannu, Jothee; Yeow, Paul H P

    2016-11-01

    Technoeconomic paradigms based economic growth theories suggest that waves of technological innovations drove the economic growth of advanced economies. Widespread economic degradation and pollution is an unintended consequence of such growth. Tackling environmental and social issues at firm levels would help us to overcome such issues at macro-levels. Consequently, the Triple Bottom Line (TBL) reporting approach promotes firm level economic, environmental and social performances. Incorporating Zink's (2014) 3-pillar presentation model, this paper indicates that economic, social and environmental performances tend to be reported at firm level. All three pillars are not covered evenly at the activity levels. Thus, a loophole is identified whereby excellent environmental performance at activity levels could potentially leave poor social performance undisclosed. A refinement of the TBL paradigm, whereby all three pillars are covered at the activity level, is suggested, to enhance sustainability reporting.

  11. 1994 Activity Report, National Synchrotron Light Source. Annual report, October 1, 1993-September 30, 1994

    SciTech Connect

    Rothman, E.Z.

    1995-05-01

    This report is a summary of activities carried out at the National Synchrotron Light Source during 1994. It consists of sections which summarize the work carried out in differing scientific disciplines, meetings and workshops, operations experience of the facility, projects undertaken for upgrades, administrative reports, and collections of abstracts and publications generated from work done at the facility.

  12. First report of a de novo 18q11.2 microdeletion including GATA6 associated with complex congenital heart disease and renal abnormalities.

    PubMed

    Bui, Peter H; Dorrani, Naghmeh; Wong, Derek; Perens, Gregory; Dipple, Katrina M; Quintero-Rivera, Fabiola

    2013-07-01

    Deletions of the long arm of chromosome 18 have been previously reported in many patients. Most cases involve the more distal regions of the long arm (18q21.1->qter). However, proximal interstitial deletions involving 18q11.2 are extremely rare. Here we report on a 14-month-old female with a 4.7 Mb (19,667,062-24,401,876 hg19) de novo interstitial deletion within chromosomal band 18q11.2, which includes GATA6 and 24 other RefSeq genes. The clinical features of our patient include complex congenital heart defects, a double outlet right ventricle, a subaortic ventricular septal defect, D-malposed great arteries, an atrial septal defect, a dysplastic aortic valve and patent ductus arteriosus. In addition, she had renal anomalies-a duplicated collecting system on the left and mild right hydronephrosis. These heart and renal defects are not reported in other patients with 18q proximal interstitial deletions. Heterozygous point mutations in GATA6, encoding for a zinc finger transcription factor, have been shown to cause congenital heart defects. Given the well-established biological role of GATA6 in cardiac development, a deletion of GATA6 is very likely responsible for our patient's complex congenital heart defects. This is the smallest and most proximal 18q11.2 deletion involving GATA6 that is associated with complex congenital heart disease and renal anomalies.

  13. Validation of reported physical activity for cholesterol control using two different physical activity instruments.

    PubMed

    Fan, Amy Z; Ham, Sandra A; Muppidi, Shravani Reddy; Mokdad, Ali H

    2009-01-01

    The National Cholesterol Education Program recommends increasing physical activity to improve cholesterol levels and overall cardiovascular health. We examined whether US adults who reported increasing their physical activity to control or lower blood cholesterol following physician's advice or on their own efforts had higher levels of physical activity than those who reported that they did not. We used data from the National Health and Nutrition Examination Survey 2003-2004, which implemented two physical activity assessment instruments. The physical activity questionnaire (PAQ) assessed self-reported frequency, intensity, and duration of leisure-time, household, and transportation-related physical activity in the past month. Physical movement was objectively monitored using a waist accelerometer that assessed minute-by-minute intensity (counts of movement/minute) during waking time over a 7-day period. We adjusted our analysis for age, gender, race/ethnicity, educational attainment, and body mass index. Participants who reported increasing physical activity to control blood cholesterol had more PAQ-assessed physical activity and more accelerometer-assessed active days per week compared to those who did not. However, there were no significant differences in cholesterol levels between comparison groups. These findings suggest that self-report of exercising more to control or lower cholesterol levels among US adults might be valid.

  14. The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.

    PubMed

    Liu, Ke; Zhang, Xiping; Lester, Robert L; Dickson, Robert C

    2005-06-17

    The Pkh1 protein kinase of Saccharomyces cerevisiae, a homolog of the mammalian 3-phosphoinositide-dependent kinase (PDK1), regulates downstream AGC-type protein kinases including Ypk1/2 and Pkc1, which control cell wall integrity, growth, and other processes. Phytosphingosine (PHS), a sphingoid long chain base, is hypothesized to be a lipid activator of Pkh1 and thereby controls the activity of Ypk1/2. Here we present biochemical evidence supporting this hypothesis, and in addition we demonstrate that PHS also stimulates autophosphorylation and activation of Ypk1/2. Greatest stimulation of Ypk1/2 phosphorylation and activity are achieved by inclusion of both PHS and Pkh1 in an in vitro kinase reaction. We also demonstrate for the first time that Pkh1 phosphorylates the Sch9 protein kinase in vitro and that such phosphorylation is stimulated by PHS. This is the first biochemical demonstration of Sch9 activators, and the results further support roles for long chain bases in heat stress resistance in addition to implying roles in chronological aging and cell size determination, since Sch9 functions in these processes. Thus, our data support a model in which PHS, rather than simply being an upstream activator of Pkh1, also activates kinases that are downstream targets of Pkh1 including Ypk1/2 and Sch9.

  15. Annual Report for 2003 Wild Horse Research and Field Activities

    USGS Publications Warehouse

    Ransom, Jason; Singer, Francis J.; Zeigenfuss, Linda C.

    2004-01-01

    This report is meant to highlight the activities of the 2003 field season, as well as to provide a general overview of the data collected. More in-depth data analysis will be conducted following the conclusion of each I phase of the research project, and in many cases will not be possible until several seasons of data are collected.

  16. 75 FR 75576 - Confidentiality of Suspicious Activity Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... criminal, tax, or regulatory investigations or proceedings, and for intelligence or counter intelligence... Office of the Comptroller of the Currency 12 CFR Part 21 RIN 1557-AD17 Confidentiality of Suspicious... (BSA) governing the confidentiality of a suspicious activity report (SAR) to: clarify the scope of...

  17. 76 FR 35902 - Agency Information Collection Activities: Report of Diversion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... of Management and Budget. Comments should be addressed to the OMB Desk Officer for Customs and Border... Doc No: 2011-15161] DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Report of Diversion AGENCY: U.S. Customs and Border Protection,...

  18. Including Youth with Intellectual Disabilities in Health Promotion Research: Development and Reliability of a Structured Interview to Assess the Correlates of Physical Activity among Youth

    ERIC Educational Resources Information Center

    Curtin, Carol; Bandini, Linda G.; Must, Aviva; Phillips, Sarah; Maslin, Melissa C. T.; Lo, Charmaine; Gleason, James M.; Fleming, Richard K.; Stanish, Heidi I.

    2016-01-01

    Background: The input of youth with intellectual disabilities in health promotion and health disparities research is essential for understanding their needs and preferences. Regular physical activity (PA) is vital for health and well-being, but levels are low in youth generally, including those with intellectual disabilities. Understanding the…

  19. Active Sites Environmental Monitoring Program: Mid-FY 1991 report

    SciTech Connect

    Ashwood, T.L.; Wickliff, D.S.; Morrissey, C.M.

    1991-10-01

    This report summarizes the activities of the Active Sites Environmental Monitoring Program (ASEMP) from October 1990 through March 1991. The ASEMP was established in 1989 by Solid Waste Operations and the Environmental Sciences Division to provide early detection and performance monitoring at active low-level radioactive waste (LLW) disposal sites in Solid Waste Storage Area (SWSA) 6 and transuranic (TRU) waste storage sites in SWSA 5 as required by chapters II and III of US Department of Energy Order 5820.2A. Monitoring results continue to demonstrate the no LLW is being leached from the storage vaults on the tumulus pads. Loading of vaults on Tumulus II began during this reporting period and 115 vaults had been loaded by the end of March 1991.

  20. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    SciTech Connect

    Molnar, Denes

    2015-09-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  1. Hearing children's voices? Including children's perspectives on their experiences of domestic violence in welfare reports prepared for the English courts in private family law proceedings.

    PubMed

    Macdonald, Gillian S

    2017-03-01

    This research examined Children and Family Court Advisory and Support Service (Cafcass) reports prepared for private family court proceedings in domestic violence cases in England. The research found that in cases where children's accounts identified them as victims of violence, these disclosures regularly disappeared from report recommendations. Particular discourses regarding 'child welfare' and 'contact' were identified, which routinely impacted on the ways in which children's voices were taken into account. Whilst culturally there has undoubtedly been an influential move towards including children's perspectives in decision-making that affects them, how these views are interpreted and represented is subject to adult 'gate-keeping' and powerful cultural and professional ideologies regarding 'child welfare' and 'post-separation family relationships'. This research found that the unrelenting influence of deeply embedded beliefs regarding the preservation or promotion of relationships with fathers continues to have the effect of marginalising issues of safeguarding, including children's voiced experiences of violence, in all but the most exceptional of cases. Rather, safeguarding concerns in respect of domestic violence and child abuse were persistently overshadowed by a dominant presumption of the overall benefits of contact with fathers.

  2. Measurement error of self-reported physical activity levels in New York City: assessment and correction.

    PubMed

    Lim, Sungwoo; Wyker, Brett; Bartley, Katherine; Eisenhower, Donna

    2015-05-01

    Because it is difficult to objectively measure population-level physical activity levels, self-reported measures have been used as a surveillance tool. However, little is known about their validity in populations living in dense urban areas. We aimed to assess the validity of self-reported physical activity data against accelerometer-based measurements among adults living in New York City and to apply a practical tool to adjust for measurement error in complex sample data using a regression calibration method. We used 2 components of data: 1) dual-frame random digit dialing telephone survey data from 3,806 adults in 2010-2011 and 2) accelerometer data from a subsample of 679 survey participants. Self-reported physical activity levels were measured using a version of the Global Physical Activity Questionnaire, whereas data on weekly moderate-equivalent minutes of activity were collected using accelerometers. Two self-reported health measures (obesity and diabetes) were included as outcomes. Participants with higher accelerometer values were more likely to underreport the actual levels. (Accelerometer values were considered to be the reference values.) After correcting for measurement errors, we found that associations between outcomes and physical activity levels were substantially deattenuated. Despite difficulties in accurately monitoring physical activity levels in dense urban areas using self-reported data, our findings show the importance of performing a well-designed validation study because it allows for understanding and correcting measurement errors.

  3. SUMMARY REPORT: THE CAUSES AND CONTROL OF ACTIVATED SLUDGE BULKING AND FOAMING

    EPA Science Inventory

    This 92-page Technology Transfer Summary Report provides reference material on the causes and controls of sludge bulking and foaming in activated sludge treatment that can be readily understood, and it includes sufficient detail to help plant operators control their systems. The ...

  4. 21 CFR 803.33 - If I am a user facility, what must I include when I submit an annual report?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE REPORTING User Facility... medical device reports, or the number assigned by us for reporting purposes in accordance with § 803.3; (2...) Date of the annual report and report numbers identifying the range of medical device reports that...

  5. Intrafamilial variable phenotype including corticobasal syndrome in a family with p.P301L mutation in the MAPT gene: first report in South America.

    PubMed

    Gatto, Emilia M; Allegri, Ricardo F; Da Prat, Gustavo; Chrem Mendez, Patricio; Hanna, David S; Dorschner, Michael O; Surace, Ezequiel I; Zabetian, Cyrus P; Mata, Ignacio F

    2017-02-10

    Frontotemporal lobar degeneration is a neuropathological disorder that causes a variety of clinical syndromes including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal syndrome (CBS). FTD associated with parkinsonism occurs frequently as a result of mutations in the C9orf72 gene and also in the genes coding for the protein associated with microtubule tau (MAPT) and progranulin (GRN) on chromosome 17 (FTDP-17). Herein, we report an Argentinean family, of Basque ancestry, with an extensive family history of behavioral variant of FTD. Twenty-one members over 6 generations composed the pedigree. An extensive neurologic and neurocognitive examination was performed on 2 symptomatic individuals and 3 nonsymptomatic individuals. Two different phenotypes were identified among affected members, CBS in the proband and FTD in his brother. DNA was extracted from blood for these 5 individuals and whole-exome sequencing was performed on 3 of them followed by Sanger sequencing of candidate genes on the other 2. In both affected individuals, a missense mutation (p.P301L; rs63751273) in exon 10 of the MAPT gene (chr17q21.3) was identified. Among MAPT mutations, p.P301L is the most frequently associated to different phenotypes: (1) aggressive, symmetrical, and early-onset Parkinsonism; (2) late parkinsonism associated with FTD; and (3) progressive supranuclear palsy but only exceptionally it is reported associated to CBS. This is the first report of the occurrence of the p.P301L-MAPT mutation in South America and supports the marked phenotypic heterogeneity among members of the same family as previously reported.

  6. Assessment of global reporting of adverse drug reactions for anti-malarials, including artemisinin-based combination therapy, to the WHO Programme for International Drug Monitoring

    PubMed Central

    2011-01-01

    Background In spite of enhanced control efforts, malaria remains a major public health problem causing close to a million deaths annually. With support from several donors, large amounts of artemisinin-based combination therapy (ACT) are being deployed in endemic countries raising safety concerns as little is known about the use of ACT in several of the settings where they are deployed. This project was undertaken to profile the provenance of the pharmacovigilance reporting of all anti-malarials, including ACT to the WHO adverse drug reaction (ADR) database (Vigibase™) over the past 40 years. Methods The WHO Programme for International Drug Monitoring, the Uppsala Monitoring Centre (UMC) provided anonymized extracts of Vigibase™ covering the period 1968-2008. All countries in the programme were clustered according to their malaria control phase and income status. The number of individual case safety reports (ICSRs) of anti-malarials was analyzed according to those clusters. Results From 1968 to 2008, 21,312 ICSRs suspecting anti-malarials were received from 64 countries. Low-income countries, that are also malaria-endemic (categorized as priority 1 countries) submitted only 1.2% of the ICSRs. Only 60 out of 21,312 ICSRs were related to ACT, 51 of which were coming from four sub-Saharan African countries. Although very few ICSRs involved artemisinin-based compounds, many of the adverse events reported were potentially serious. Conclusions This paper illustrates the low reporting of ADRs to anti-malarials in general and ACT in particular. Most reports were submitted by non-endemic and/or high-income countries. Given the current mix of large donor funding, the insufficient information on safety of these drugs, increasing availability of ACT and artemisinin-based monotherapies in public and private sector channels, associated potential for inappropriate use and finally a pipeline of more than 10 new novel anti-malarials in various stages of development, the

  7. Paris Observatory Analysis Center (OPAR): Report on Activities, January - December 2012

    NASA Technical Reports Server (NTRS)

    Lambert, Sebastien; Barache, Christophe

    2013-01-01

    We report on activities of the Paris Observatory VLBI Analysis Center (OPAR) for calendar year 2012 concerning the development of operational tasks, the development of our Web site, and various other activities: monitoring of the Earth's free core nutation, measuring of the post-seismic displacements of some stations, and the analysis of the recent IVS R&D sessions, including observations of quasars close to the Sun.

  8. 2015 Summary Report on Industrial and Regulatory Engagement Activities

    SciTech Connect

    Thomas, Kenneth David

    2015-09-01

    The Advanced Instrumentation, Information, and Control (II&C) Systems Technologies pathway of the Light Water Reactor Sustainability(LWRS) Program conducts a vigorous engagement strategy with the U.S. nuclear power industry, including the nuclear operating companies, major support organizations, the Nuclear Regulatory Commission (NRC), and suppliers. The goal of this engagement strategy is to develop a shared vision and common understanding across the nuclear industry of the need for II&C modernization, the performance improvement that can be obtained, and the opportunities for collaboration to enact this vision. The primary means of engaging the nuclear operating companies is through a Utility Working Group (UWG), composed of utility representatives that participate in formal meetings and bi-monthly phone calls to provide input on nuclear plant needs and priorities for II&C technologies. Two working groups were initiated during FY 2015 to provide a means for UWG members to focus on particular technologies of interest. The Outage Improvement Working Group consists of eight utilities that participate in periodic conference calls and have access to a share-point web page for acccess to project materials developed in the Advanced Outage Control Center pilot project. In the area of computer-based procedures and automated work packages, the II&C Pathway has worked with the Nuclear Information Technology Strategic Leadership (NITSL) to set up a monthly conference call with interested utility members to discuss various aspects of mobile worker technologies. Twenty one technical and project reports were delivered to the UWG during FY 2015, reflecting the work of the II&C Pathway pilot projects during the year. Distribution of these reports is one of the primary means of transferring to the nuclear industry the knowledge and experience gained during the development of advanced II&C technologies in support of LWR sustainability. Site visits to discuss pilot project

  9. Report on Active and Planned Spacecraft and Experiments. [bibliographies

    NASA Technical Reports Server (NTRS)

    Vostreys, R. W. (Editor); Horwitz, R. (Editor)

    1979-01-01

    Information concerning concerning active and planned spacecraft and experiments known to the National Space Science Data Center are included. The information contains a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and funding of individual countries as well as cooperative arrangements among different countries. Approximately 850 articles are included.

  10. Systematic review of patient-reported outcome measures (PROMs) for assessing disease activity in rheumatoid arthritis

    PubMed Central

    de Jonge, Marieke J; Fransen, Jaap; Kievit, Wietske; van Riel, Piet LCM

    2016-01-01

    Patient assessment of disease activity in rheumatoid arthritis (RA) may be useful in clinical practice, offering a patient-friendly, location independent, and a time-efficient and cost-efficient means of monitoring the disease. The objective of this study was to identify patient-reported outcome measures (PROMs) to assess disease activity in RA and to evaluate the measurement properties of these measures. Systematic literature searches were performed in the PubMed and EMBASE databases to identify articles reporting on clinimetric development or evaluation of PROM-based instruments to monitor disease activity in patients with RA. 2 reviewers independently selected articles for review and assessed their methodological quality based on the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) recommendations. A total of 424 abstracts were retrieved for review. Of these abstracts, 56 were selected for reviewing the full article and 34 articles, presenting 17 different PROMs, were finally included. Identified were: Rheumatoid Arthritis Disease Activity Index (RADAI), RADAI-5, Patient-based Disease Activity Score (PDAS) I & II, Patient-derived Disease Activity Score with 28-joint counts (Pt-DAS28), Patient-derived Simplified Disease Activity Index (Pt-SDAI), Global Arthritis Score (GAS), Patient Activity Score (PAS) I & II, Routine Assessment of Patient Index Data (RAPID) 2–5, Patient Reported Outcome-index (PRO-index) continuous (C) & majority (M), Patient Reported Outcome CLinical ARthritis Activity (PRO-CLARA). The quality of reports varied from poor to good. Typically 5 out of 10 clinimetric domains were covered in the validations of the different instruments. The quality and extent of clinimetric validation varied among PROMs of RA disease activity. The Pt-DAS28, RADAI, RADAI-5 and RAPID 3 had the strongest and most extensive validation. The measurement properties least reported and in need of more evidence were: reliability

  11. Assessing adult leisure activities: an extension of a self-report activity questionnaire.

    PubMed

    Jopp, Daniela S; Hertzog, Christopher

    2010-03-01

    Everyday leisure activities in adulthood and old age have been investigated with respect to constructs such as successful aging, an engaged lifestyle, and prevention of age-related cognitive decline. They also relate to mental health and have clinical value, as they can inform diagnosis and interventions. In the present study, the authors enhanced the content validity of the Victoria Longitudinal Study activity questionnaire by adding items on physical and social activities and validated a shortened version of the questionnaire. The proposed leisure activity model included 11 activity categories: 3 types of social activities (i.e., activities with close social partners, group-centered public activity, religious activities), physical activities, developmental activities, experiential activities, crafts, game playing, TV watching, travel, and technology use. Confirmatory factor analyses validated the proposed factor structure in 2 independent samples. A higher order model with a general activity factor fitted the activity factor correlations with relatively little loss of fit. Convergent and discriminant validity for the activity scales were supported by patterns of their correlations with education, health, depression, cognition, and personality. In sum, the scores derived from of the augmented Victoria Longitudinal Study activity questionnaire demonstrate good reliability, and validity evidence supports their use as measures of leisure activities in young, middle-aged, and older individuals.

  12. NASA's Microgravity Technology Report, 1996: Summary of Activities

    NASA Technical Reports Server (NTRS)

    Kierk, Isabella

    1996-01-01

    This report covers technology development and technology transfer activities within the Microgravity Science Research Programs during FY 1996. It also describes the recent major tasks under the Advanced Technology Development (ATD) Program and identifies current technology requirements. This document is consistent with NASA,s Enteprise for the Human Exploration and development of Space (HEDS) Strategic Plan. This annual update reflects changes in the Microgravity Science Research Program's new technology activities and requirements. Appendix A. FY 1996 Advanced Technology Development. Program and Project Descriptions. Appendix B. Technology Development.

  13. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Brecht, J. J. (Editor)

    1974-01-01

    Information dealing with active and planned spacecraft and experiments known to the National Space Science Data Center (NSSDC) is presented. Included is information concerning a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft represent the efforts and funding of individual countries, as well as cooperative arrangements among different countries.

  14. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Littlefield, R. G. (Editor)

    1983-01-01

    Information concerning active and planned spacecraft and experiments is included. The information covers a wide range of scientific disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and fundng of individual countries as well as cooperative arrangements among different countries.

  15. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Vette, J. I. (Editor); Vostreys, R. W. (Editor); Horowitz, R. (Editor)

    1978-01-01

    Information is presented, concerning active and planned spacecraft and experiments known to the National Space Science Data Center. The information included a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represented the efforts and funding of individual countries as well as cooperative arrangements among different countries.

  16. Aeronautics and Space Report of the President: Fiscal Year 1998 Activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year. In recent years, the reports have been prepared on a fiscal year (FY) basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1997, through September 30, 1998. The activities of agencies included are NASA, the Department of Defense, The Federal Aviation Administration, the Department of Commerce, the Department of the Interior, the Federal Communications Commission, the Department of Agriculture, the National Science Foundation, the Department of State, the Department of Energy, the Smithsonian Institution, the Arms Control and Disarmament Agency, the Environmental Protection Agency, and the U.S. Information Agency. Appendices cover the U.S. Government Spacecraft Record, World Record of Space Launches Successful in Attaining Earth Orbit or Beyond , Successful Launches to Orbit on U.S. Launch Vehicles, October 1, 1997-September 30, 1998, U.S. and Russian Human Space Flights, 1961-September 30, 1998, U.S. Space Launch Vehicles, Space Activities of the U.S. Government-Historical Budget Summary, Space Activities of the U.S. Government-Budget Authority in Equivalent FY 1998 Dollars, Federal Space Activities Budget, Federal Aeronautics Budget, and a glossary

  17. High Energy Physics Division semiannual report of research activities, July 1, 1990--December 31, 1990

    SciTech Connect

    Berger, E.; Moonier, P.; May, E.; Norem, J.

    1991-02-01

    A report is presented of research and development activities conducted in the High Energy Physics Division at Argonne National Laboratory during the six month period July 1 through December 31, 1990. Analyses of data from experiments performed by members of the Division are summarized, and the status of experiments taking data and of those being prepared is reviewed. Descriptions are included of research on theoretical and phenomenological topics in particle physics. Progress reports are provided on accelerator research and development, detector research and development, and experimental facilities research. Lists are presented of publications, of colloquia and conference talks, and of significant external community activities of members of the Division.

  18. Final Report: Imaging of Buried Nanoscale Optically Active Materials

    SciTech Connect

    Appelbaum, Ian

    2011-07-05

    This is a final report covering work done at University of Maryland to develop a Ballistic Electron Emission Luminescence (BEEL) microscope. This technique was intended to examine the carrier transport and photon emission in deeply buried optically-active layers and thereby provide a means for materials science to unmask the detailed consequences of experimentally controllable growth parameters, such as quantum dot size, statistics and orientation, and defect density and charge recombination pathways.

  19. Managing Suspicious Activity Reporting Systems at Small Agency Police Departments

    DTIC Science & Technology

    2012-09-01

    61,571 53 Mountain view X 72,222 54 Napa X X 75,279 54 Suspicious Activity Reporting Population: 50,000–99,999 Agency SAR on...Montebello Napa Novato Perris Pittsburg Rancho Santa Margarita Redondo Beach Rosemead San Mateo Santa...Friday FBI’s LE Officers Killed and Assaulted(LEOKA) Napa , CA July 10-11, 2012; Tuesday - Wednesday Enhanced Threat and Risk Assessment

  20. Triennial Report 2006-2009. Commission 10: Solar Activity

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2008-01-01

    Commission 10 deals with solar activity in all of its forms, ranging from the smallest nanoflares to the largest coronal mass ejections. This report reviews scientific progress over the roughly two-year period ending in the middle of 2008. This has been an exciting time in solar physics, highlighted by the launches of the Hinode and STEREO missions late in 2006. The report is reasonably comprehensive, though it is far from exhaustive. Limited space prevents the inclusion of many significant results. The report is divided into following sections: Photosphere and Chromosphere; Transition Region; Corona and Coronal Heating; Coronal Jets; Flares; Coronal Mass Ejection Initiation; Global Coronal Waves and Shocks; Coronal Dimming; The Link Between Low Coronal CME signatures and Magnetic Clouds; Coronal Mass Ejections in the Heliosphere; and Coronal Mass Ejections and Space Weather. Primary authorship is indicated at the beginning of each section.

  1. Current state of evidence on 'off-label' therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria and Switzerland--a consensus report.

    PubMed

    Aringer, M; Burkhardt, H; Burmester, G R; Fischer-Betz, R; Fleck, M; Graninger, W; Hiepe, F; Jacobi, A M; Kötter, I; Lakomek, H J; Lorenz, H M; Manger, B; Schett, G; Schmidt, R E; Schneider, M; Schulze-Koops, H; Smolen, J S; Specker, C; Stoll, T; Strangfeld, A; Tony, H P; Villiger, P M; Voll, R; Witte, T; Dörner, T

    2012-04-01

    Systemic lupus erythematosus (SLE) can be a severe and potentially life-threatening disease that often represents a therapeutic challenge because of its heterogeneous organ manifestations. Only glucocorticoids, chloroquine and hydroxychloroquine, azathioprine, cyclophosphamide and very recently belimumab have been approved for SLE therapy in Germany, Austria and Switzerland. Dependence on glucocorticoids and resistance to the approved therapeutic agents, as well as substantial toxicity, are frequent. Therefore, treatment considerations will include 'off-label' use of medication approved for other indications. In this consensus approach, an effort has been undertaken to delineate the limits of the current evidence on therapeutic options for SLE organ disease, and to agree on common practice. This has been based on the best available evidence obtained by a rigorous literature review and the authors' own experience with available drugs derived under very similar health care conditions. Preparation of this consensus document included an initial meeting to agree upon the core agenda, a systematic literature review with subsequent formulation of a consensus and determination of the evidence level followed by collecting the level of agreement from the panel members. In addition to overarching principles, the panel have focused on the treatment of major SLE organ manifestations (lupus nephritis, arthritis, lung disease, neuropsychiatric and haematological manifestations, antiphospholipid syndrome and serositis). This consensus report is intended to support clinicians involved in the care of patients with difficult courses of SLE not responding to standard therapies by providing up-to-date information on the best available evidence.

  2. Assessing Adult Leisure Activities: An Extension of a Self-Report Activity Questionnaire

    PubMed Central

    Jopp, Daniela; Hertzog, Christopher

    2009-01-01

    Everyday leisure activities in adulthood and old age have been investigated with respect to constructs such as successful aging, an engaged lifestyle, and prevention of age-related cognitive decline. They also relate to mental health and have clinical value as they can inform diagnosis and interventions. In the present study, we enhanced the content validity of the Victoria Longitudinal Study activity questionnaire by adding items on physical and social activities, and validated a shortened version of the questionnaire. Our proposed leisure activity model included 11 activity categories: three types of social activities (i.e., activities with close social partners, group-centered public activity, religious activities), physical, developmental, and experiential activities, crafts, game playing, TV watching, travel, and technology use. Confirmatory factor analyses validated the proposed factor structure in two independent samples. A higher-order model with a general activity factor fitted the activity factor correlations with relatively little loss of fit. Convergent and discriminant validity for the activity scales were supported by patterns of their correlations with education, health, depression, cognition, and personality. In sum, the scores derived from of the augmented VLS activity questionnaire demonstrate good reliability, and validity evidence supports their use as measure of leisure activities in young, middle-aged, and older individuals. PMID:20230157

  3. Physical Activity Assessment: Biomarkers and Self-Report of Activity-Related Energy Expenditure in the WHI

    PubMed Central

    Neuhouser, Marian L.; Di, Chongzhi; Tinker, Lesley F.; Thomson, Cynthia; Sternfeld, Barbara; Mossavar-Rahmani, Yasmin; Stefanick, Marcia L.; Sims, Stacy; Curb, J. David; Lamonte, Michael; Seguin, Rebecca; Johnson, Karen C.; Prentice, Ross L

    2013-01-01

    We used a biomarker of activity-related energy expenditure (AREE) to assess measurement properties of self-reported physical activity and to determine the usefulness of AREE regression calibration equations in the Women's Health Initiative. Biomarker AREE, calculated as the total energy expenditure from doubly labeled water minus the resting energy expenditure from indirect calorimetry, was assessed in 450 Women's Health Initiative participants (2007–2009). Self-reported AREE was obtained from the Arizona Activity Frequency Questionnaire (AAFQ), the 7-Day Physical Activity Recall (PAR), and the Women's Health Initiative Personal Habits Questionnaire (PHQ). Eighty-eight participants repeated the protocol 6 months later. Reporting error, measured as log(self-report AREE) minus log(biomarker AREE), was regressed on participant characteristics for each instrument. Body mass index was associated with underreporting on the AAFQ and PHQ but overreporting on PAR. Blacks and Hispanics underreported physical activity levels on the AAFQ and PAR, respectively. Underreporting decreased with age for the PAR and PHQ. Regressing logbiomarker AREE on logself-reported AREE revealed that self-report alone explained minimal biomarker variance (R2 = 7.6, 4.8, and 3.4 for AAFQ, PAR, and PHQ, respectively). R2 increased to 25.2, 21.5, and 21.8, respectively, when participant characteristics were included. Six-month repeatability data adjusted for temporal biomarker variation, improving R2 to 79.4, 67.8, and 68.7 for AAFQ, PAR, and PHQ, respectively. Calibration equations “recover” substantial variation in average AREE and valuably enhance AREE self-assessment. PMID:23436896

  4. Rehabilitation Services Administration Annual Report, Fiscal Year 2004: Report on Federal Activities under the "Rehabilitation Act"

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The "Rehabilitation Act of 1973," as amended (the act), provides the legislative basis for programs and activities that assist individuals with disabilities in the pursuit of gainful employment, independence, self-sufficiency and full integration into community life. This report is intended to provide a description of accomplishments and…

  5. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....C. 1813(u) and 1818(b)(9)). (iii) SAR means a Suspicious Activity Report. (3) SARs required. A... action. (11) Obtaining SARs. A savings association or service corporation may obtain SARs and the...) Confidentiality of SARs. A SAR, and any information that would reveal the existence of a SAR, are...

  6. 12 CFR 390.355 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Activity Report on the form prescribed by the FDIC. (3) SARs required. A State savings association shall... to supervisory action. (11) Obtaining SARs. A State savings association may obtain SARs and the... SARs. SARs are confidential. Any institution or person subpoenaed or otherwise requested to disclose...

  7. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....C. 1813(u) and 1818(b)(9)). (iii) SAR means a Suspicious Activity Report. (3) SARs required. A... action. (11) Obtaining SARs. A savings association or service corporation may obtain SARs and the...) Confidentiality of SARs. A SAR, and any information that would reveal the existence of a SAR, are...

  8. 12 CFR 163.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Suspicious Activity Report. (3) SARs required. A savings association or service corporation shall file a SAR... other institution-affiliated parties to supervisory action. (11) Obtaining SARs. A savings association or service corporation may obtain SARs and the instructions from the appropriate Federal...

  9. 12 CFR 390.355 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Activity Report on the form prescribed by the FDIC. (3) SARs required. A State savings association shall... to supervisory action. (11) Obtaining SARs. A State savings association may obtain SARs and the... SARs. SARs are confidential. Any institution or person subpoenaed or otherwise requested to disclose...

  10. 12 CFR 390.355 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Activity Report on the form prescribed by the FDIC. (3) SARs required. A State savings association shall... to supervisory action. (11) Obtaining SARs. A State savings association may obtain SARs and the... SARs. SARs are confidential. Any institution or person subpoenaed or otherwise requested to disclose...

  11. 12 CFR 163.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Suspicious Activity Report. (3) SARs required. A savings association or service corporation shall file a SAR... other institution-affiliated parties to supervisory action. (11) Obtaining SARs. A savings association or service corporation may obtain SARs and the instructions from the appropriate Federal...

  12. One reporter for in-cell activity profiling of majority of protein kinase oncogenes.

    PubMed

    Gudernova, Iva; Foldynova-Trantirkova, Silvie; Ghannamova, Barbora El; Fafilek, Bohumil; Varecha, Miroslav; Balek, Lukas; Hruba, Eva; Jonatova, Lucie; Jelinkova, Iva; Kunova Bosakova, Michaela; Trantirek, Lukas; Mayer, Jiri; Krejci, Pavel

    2017-02-15

    In-cell profiling enables the evaluation of receptor tyrosine activity in a complex environment of regulatory networks that affect signal initiation, propagation and feedback. We used FGF-receptor signaling to identify EGR1 as a locus that strongly responds to the activation of a majority of the recognized protein kinase oncogenes, including 30 receptor tyrosine kinases and 154 of their disease-associated mutants. The EGR1 promoter was engineered to enhance trans-activation capacity and optimized for simple screening assays with luciferase or fluorescent reporters. The efficacy of the developed, fully synthetic reporters was demonstrated by the identification of novel targets for two clinically used tyrosine kinase inhibitors, nilotinib and osimertinib. A universal reporter system for in-cell protein kinase profiling will facilitate repurposing of existing anti-cancer drugs and identification of novel inhibitors in high-throughput screening studies.

  13. One reporter for in-cell activity profiling of majority of protein kinase oncogenes

    PubMed Central

    Gudernova, Iva; Foldynova-Trantirkova, Silvie; Ghannamova, Barbora El; Fafilek, Bohumil; Varecha, Miroslav; Balek, Lukas; Hruba, Eva; Jonatova, Lucie; Jelinkova, Iva; Bosakova, Michaela Kunova; Trantirek, Lukas; Mayer, Jiri; Krejci, Pavel

    2017-01-01

    In-cell profiling enables the evaluation of receptor tyrosine activity in a complex environment of regulatory networks that affect signal initiation, propagation and feedback. We used FGF-receptor signaling to identify EGR1 as a locus that strongly responds to the activation of a majority of the recognized protein kinase oncogenes, including 30 receptor tyrosine kinases and 154 of their disease-associated mutants. The EGR1 promoter was engineered to enhance trans-activation capacity and optimized for simple screening assays with luciferase or fluorescent reporters. The efficacy of the developed, fully synthetic reporters was demonstrated by the identification of novel targets for two clinically used tyrosine kinase inhibitors, nilotinib and osimertinib. A universal reporter system for in-cell protein kinase profiling will facilitate repurposing of existing anti-cancer drugs and identification of novel inhibitors in high-throughput screening studies. DOI: http://dx.doi.org/10.7554/eLife.21536.001 PMID:28199182

  14. The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts

    PubMed Central

    Hendrayani, Siti-Fauziah; Al-Harbi, Bothaina; Al-Ansari, Mysoon M.; Silva, Gabriela; Aboussekhra, Abdelilah

    2016-01-01

    The IL-6/STAT3/NF-κB positive feedback loop links inflammation to cancer and maintains cells at a transformed state. Similarly, cancer-associated myofibroblats remains active even in absence of cancer cells. However, the molecular basis of this sustained active state remains elusive. We have shown here that breast cancer cells and IL-6 persistently activate breast stromal fibroblasts through the stimulation of the positive IL-6/STAT3/NF-κB feedback loop. Transient neutralization of IL-6 in culture inhibited this signaling circuit and reverted myofibrobalsts to a normalized state, suggesting the implication of the IL-6 autocrine feedback loop as well. Importantly, the IL-6/STAT3/NF-κB pro-inflammatory circuit was also active in cancer-associated fibroblasts isolated from breast cancer patients. Transient inhibition of STAT3 by specific siRNA in active fibroblasts persistently reduced the level of the RNA binding protein AUF1, blocked the loop and normalized these cells. Moreover, we present clear evidence that AUF1 is also part of this positive feedback loop. Interestingly, treatment of breast myofibroblasts with caffeine, which has been previously shown to persistently inhibit active breast stromal fibroblasts, blocked the positive feedback loop through potent and sustained inhibition of STAT3, AKT, lin28B and AUF1. These results indicate that the IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and is responsible for the sustained active status of cancer-associated fibroblasts. We have also shown that normalizing myofibroblasts, which could be of great therapeutic value, is possible through the inhibition of this procarcinogenic circuit. PMID:27248826

  15. 21 CFR 803.33 - If I am a user facility, what must I include when I submit an annual report?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... when I submit an annual report? (a) You must submit to us an annual report on FDA Form 3419, or electronic equivalent as approved by us under § 803.14. You must submit an annual report by January 1, of...) Your CMS provider number used for medical device reports, or the number assigned by us for...

  16. Hormonal activity of polycyclic musks evaluated by reporter gene assay.

    PubMed

    Mori, Taiki; Iida, Mitsuru; Ishibashi, Hiroshi; Kohra, Shinya; Takao, Yuji; Takemasa, Takehiro; Arizono, Koji

    2007-01-01

    Synthetic musk fragrance compounds, such as polycyclic musks (PCMs), are a group of chemicals used extensively as personal care products, and can be found in the environment and the human body. PCMs, such as 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexa-methylcyclopenta-gamma-2-benzopyran (HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyltetralin (AHTN), are known to have agonistic activities toward human estrogen receptor alpha (hERalpha) and hERbeta, and have antagonistic activity toward the human androgen receptor (hAR), as shown in several reporter gene assays. However, little is known about the interaction of PCMs with the human thyroid hormone receptor (hTR), and the hormonal effects of other PCMs except for HHCB and AHTN. In this study, we focus on the interactions of six PCMs, namely, HHCB, AHTN, 4-acetyl-1,1-dimethyl-6-tert-butyl-indan (ADBI), 6-acetyl-1,1,2,3,3,5-hexamethylindan (AHMI), 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone (DPMI), and 5-acetyl-1,1,2,6-tetramethyl-3-isopropy-lindan (ATII) with hERalpha, hAR, and hTRbeta by in vitro reporter gene assay using Chinese hamster ovary cells. All the samples were found to be agonists toward hERalpha, whereas no agonistic activities of these PCMs for hAR and hTRbeta were observed. No antagonistic activities for hERalpha and hTRbeta were observed at the concentrations tested. However, several PCMs, namely, HHCB, AHTN, ATII, ADBI, and AHMI, showed dose-dependent antagonistic activities for hAR, and the IC50 values of these compounds were estimated to be 1.0 x 10(-7), 1.5 x 10(-7), 1.4 x 10(-7), 9.8 x 10(-6), and 1.4 x 10(-7) M, respectively. The results suggest that these PCMs interact with hERalpha and hAR but have no hormonal effect on hTRbeta. This is the first report on the agonistic and antagonistic activities of ATII, ADBI, AHMI, and DPMI for hERalpha and hAR as determined by in vitro reporter gene assay using stably transfected Chinese hamster ovary cells.

  17. Wakame and Nori in restructured meats included in cholesterol-enriched diets affect the antioxidant enzyme gene expressions and activities in Wistar rats.

    PubMed

    Moreira, Adriana Schultz; González-Torres, Laura; Olivero-David, Raul; Bastida, Sara; Benedi, Juana; Sánchez-Muniz, Francisco J

    2010-09-01

    The effects of diets including restructured meats (RM) containing Wakame or Nori on total liver glutathione status, and several antioxidant enzyme gene expressions and activities were tested. Six groups of ten male growing Wistar rats each were fed a mix of 85% AIN-93 M diet and 15% freeze-dried RM for 35 days. The control group (C) consumed control RM, the Wakame (W) and the Nori (N) groups, RM with 5% Wakame and 5% Nori, respectively. Animals on added cholesterol diets (CC, CW, and CN) consumed their corresponding basal diets added with cholesterol (2%) and cholic acid (0.4%). Alga and dietary cholesterol significantly interact (P < 0.002) influencing all enzyme expressions but not activities. The cholesterol supplement decreased most enzyme expression and activity. W-RM vs. C-RM increased (P < 0.05) expression of GPx, GR, Mn-SOD, and Cu,Zn-SOD and decreased that of catalase. N-RM vs. C-RM increased (P < 0.05) expression of catalase and Mn-SOD. GR activity increased in W-RM rats while SOD activity increased, but that of Se-GPx decreased in N animals. W-RM increased total and reduced glutathione and decreased the redox index. CN diet induced significantly lower plasma cholesterol levels (P < 0.001) than the CW diet. In conclusion, Nori-RM is a hypocholesterolemic food while Wakame-RM is an antioxidant food. This should be taken into account when including this kind of RM as potential functional foods in human.

  18. Annual Report '77. NLC: Nebraska Library Commission. 1976-77 Statistical Report, 1976-78 Activities Report, 1978 Directory.

    ERIC Educational Resources Information Center

    Nebraska Library Commission, Lincoln.

    This annual report for the year 1977 describes the functions, services, and activities of the Nebraska Library Commission (NLC), an independent agency within the Nebraska state government which is responsible for the distribution of federal library funds, the statewide development and coordination of library programs, and the collection of…

  19. 2010 Workplace and Gender Relations Survey of Active Duty Members. Overview Report on Sexual Harassment

    DTIC Science & Technology

    2011-04-01

    2010 Workplace and Gender Relations Survey of Active Duty Members Overview Report on Sexual Harassment Additional copies of this report may...SURVEY OF ACTIVE DUTY MEMBERS: OVERVIEW REPORT ON SEXUAL HARASSMENT Lindsay M. Rock and Rachel N. Lipari Defense Manpower... ACTIVE DUTY MEMBERS: OVERVIEW REPORT ON SEXUAL HARASSMENT Executive Summary Background This report presents the results on issues related to

  20. Carcinoma showing thymus-like elements of the thyroid gland: report of three cases including one case with breast cancer history.

    PubMed

    Zhang, Guanjun; Liu, Xi; Huang, Wei; Li, Xiaofeng; Johnstone, Marianne; Deng, Yuan; Ke, Yongqiang; Nunes, Quentin M; Wang, Hongyan; Wang, Yili; Zhang, Xuebin

    2015-01-01

    Carcinoma showing thymus-like elements (CASTLE) is a rare malignant tumor of the thyroid or adjacent neck soft tissues, whose histogenesis is still debated. It may resemble other primary or metastatic poorly differentiated tumors histologically and the differential diagnosis is crucial for CASTLE has a better prognosis. However, CASTLE as a second primary tumor has not been reported in the literature. We report three cases of thyroid CASTLE, including a unique tumor following breast-conserving surgery for early-stage breast invasive carcinoma. There were two female and one male. All three tumors were located in the right lobe of the thyroid, and one tumor showed extension into the surrounding soft tissue. Histologically, all tumors showed expansive growth and consisted of cords, nests or sheets of epithelial cells divided into irregularly shaped lobules by fibrous connective tissue with lymphoplasmacytic infiltration. Focal squamous differentiation resembling Hassall's corpuscles were observed. All cases stained positively for CD5, CD117, high molecular weight cytokeratin, cytokeratin, P63, carcinoembryonic antigen and epithelial membrane antigen. Positive staining for Bcl-2 in two cases and chromogranin A in one case was noted. Ki-67 expression ranged from 15 to 25%. Thyroid transcription factor and CD3 were negative. There was no evidence of recurrent or metastatic disease at following surgery. These features demonstrated CASTLE may arise from branchial pouch remnants, the thyroid solid cell nests. CASTLE is a rare entity, awareness of its occurrence as a second primary tumor is important to avoid overtreatment because it is associated with a favorable prognosis.

  1. Aeronautics and space report of the president, 1974 activities

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The U.S. Government activities for 1974 in aeronautics and space are presented. Significant contributions toward the fulfillment of the nation's goals in space and aeronautics are covered, including application of space systems and technology to beneficial uses on earth, exploration of space and increase of scientific knowledge, development of improved space systems and technology, international cooperation, and advancement of civil and military aeronautics. Also in 1974, space activities in the private sector expanded to provide additional services to the public. The accomplishments are summarized.

  2. Apollo experience report: Assessment of metabolic expenditures. [extravehicular activity

    NASA Technical Reports Server (NTRS)

    Waligora, J. M.; Hawkins, W. R.; Humbert, G. F.; Nelson, L. J.; Vogel, S. J.; Kuznetz, L. H.

    1975-01-01

    A significant effort was made to assess the metabolic expenditure for extravehicular activity on the lunar surface. After evaluation of the real-time data available to the flight controller during extravehicular activity, three independent methods of metabolic assessment were chosen based on the relationship between heart rate and metabolic production, between oxygen consumption and metabolic production, and between the thermodynamics of the liquid-cooled garment and metabolic production. The metabolic assessment procedure is analyzed and discussed. Real-time use of this information by the Apollo flight surgeon is discussed. Results and analyses of the Apollo missions and comments concerning future applications are included.

  3. The Association between Access to Public Transportation and Self-Reported Active Commuting

    PubMed Central

    Djurhuus, Sune; Hansen, Henning S.; Aadahl, Mette; Glümer, Charlotte

    2014-01-01

    Active commuting provides routine-based regular physical activity which can reduce the risk of chronic diseases. Using public transportation involves some walking or cycling to a transit stop, transfers and a walk to the end location and users of public transportation have been found to accumulate more moderate physical activity than non-users. Understanding how public transportation characteristics are associated with active transportation is thus important from a public health perspective. This study examines the associations between objective measures of access to public transportation and self-reported active commuting. Self-reported time spent either walking or cycling commuting each day and the distance to workplace were obtained for adults aged 16 to 65 in the Danish National Health Survey 2010 (n = 28,928). Access to public transportation measures were computed by combining GIS-based road network distances from home address to public transit stops an integrating their service level. Multilevel logistic regression was used to examine the association between access to public transportation measures and active commuting. Distance to bus stop, density of bus stops, and number of transport modes were all positively associated with being an active commuter and with meeting recommendations of physical activity. No significant association was found between bus services at the nearest stop and active commuting. The results highlight the importance of including detailed measurements of access to public transit in order to identify the characteristics that facilitate the use of public transportation and active commuting. PMID:25489998

  4. The association between access to public transportation and self-reported active commuting.

    PubMed

    Djurhuus, Sune; Hansen, Henning S; Aadahl, Mette; Glümer, Charlotte

    2014-12-05

    Active commuting provides routine-based regular physical activity which can reduce the risk of chronic diseases. Using public transportation involves some walking or cycling to a transit stop, transfers and a walk to the end location and users of public transportation have been found to accumulate more moderate physical activity than non-users. Understanding how public transportation characteristics are associated with active transportation is thus important from a public health perspective. This study examines the associations between objective measures of access to public transportation and self-reported active commuting. Self-reported time spent either walking or cycling commuting each day and the distance to workplace were obtained for adults aged 16 to 65 in the Danish National Health Survey 2010 (n = 28,928). Access to public transportation measures were computed by combining GIS-based road network distances from home address to public transit stops an integrating their service level. Multilevel logistic regression was used to examine the association between access to public transportation measures and active commuting. Distance to bus stop, density of bus stops, and number of transport modes were all positively associated with being an active commuter and with meeting recommendations of physical activity. No significant association was found between bus services at the nearest stop and active commuting. The results highlight the importance of including detailed measurements of access to public transit in order to identify the characteristics that facilitate the use of public transportation and active commuting.

  5. Applying the Model of Goal-Directed Behavior, Including Descriptive Norms, to Physical Activity Intentions: A Contribution to Improving the Theory of Planned Behavior.

    PubMed

    Esposito, Gabriele; van Bavel, René; Baranowski, Tom; Duch-Brown, Néstor

    2016-08-01

    The theory of planned behavior (TPB) has received its fair share of criticism lately, including calls for it to retire. We contribute to improving the theory by testing extensions such as the model of goal-directed behavior (MGDB, which adds desire and anticipated positive and negative emotions) applied to physical activity (PA) intention. We also test the inclusion of a descriptive norms construct as an addition to the subjective norms construct, also applied to PA, resulting in two additional models: TPB including descriptive norms (TPB + DN) and MGDB including descriptive norms (MGDB + DN). The study is based on an online survey of 400 young adult Internet users, previously enrolled in a subject pool. Confirmatory factor analysis (CFA) showed that TPB and TPB + DN were not fit for purpose, while MGDB and MGDB + DN were. Structural equation modelling (SEM) conducted on MGDB and MGDB + DN showed that the inclusion of descriptive norms took over the significance of injunctive norms, and increased the model's account of total variance in intention to be physically active.

  6. STS-99 Crew Activities Report/Flight Day 1 Highlights

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Live footage shows the crew, Commander Kevin R. Kregel, Pilot Dominic L. Pudwill Gorie, and Mission Specialists Janet L. Kavandi, Janice E. Voss, Mamoru Mohri and Gerhard P.J. Thiele, seated in the dining room with the traditional cake. The crew is seen performing various pre-launch activities including suit-up, walk out to the Astro-van, and strap-in into the vehicle. Also seen are the retractions of the orbiter access arm and the gaseous oxygen mint hood, main engine start, booster ignition, liftoff, and separation of the solid rocket boosters. The Red Team (first of the dual shift crew) includes Kregel, Kavandi, and Thiele, who are shown conducting jet thruster firings, activating radar instruments, and deploying the boom (mass).

  7. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory; determination of 86 volatile organic compounds in water by gas chromatography/mass spectrometry, including detections less than reporting limits

    USGS Publications Warehouse

    Connor, Brooke F.; Rose, Donna L.; Noriega, Mary C.; Murtaugh, Lucinda K.; Abney, Sonja R.

    1998-01-01

    This report presents precision and accuracy data for volatile organic compounds (VOCs) in the nanogram-per-liter range, including aromatic hydrocarbons, reformulated fuel components, and halogenated hydrocarbons using purge and trap capillary-column gas chromatography/mass spectrometry. One-hundred-four VOCs were initially tested. Of these, 86 are suitable for determination by this method. Selected data are provided for the 18 VOCs that were not included. This method also allows for the reporting of semiquantitative results for tentatively identified VOCs not included in the list of method compounds. Method detection limits, method performance data, preservation study results, and blank results are presented. The authors describe a procedure for reporting low-concentration detections at less than the reporting limit. The nondetection value (NDV) is introduced as a statistically defined reporting limit designed to limit false positives and false negatives to less than 1 percent. Nondetections of method compounds are reported as ?less than NDV.? Positive detections measured at less than NDV are reported as estimated concentrations to alert the data user to decreased confidence in accurate quantitation. Instructions are provided for analysts to report data at less than the reporting limits. This method can support the use of either method reporting limits that censor detections at lower concentrations or the use of NDVs as reporting limits. The data-reporting strategy for providing analytical results at less than the reporting limit is a result of the increased need to identify the presence or absence of environmental contaminants in water samples at increasingly lower concentrations. Long-term method detection limits (LTMDLs) for 86 selected compounds range from 0.013 to 2.452 micrograms per liter (?g/L) and differ from standard method detection limits (MDLs) in that the LTMDLs include the long-term variance of multiple instruments, multiple operators, and multiple

  8. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  9. Aeronautics and space report of the President, 1980 activities

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The year's achievements in the areas of communication, Earth resources, environment, space sciences, transportation, and space energy are summarized and current and planned activities in these areas at the various departments and agencies of the Federal Government are summarized. Tables show U.S. and world spacecraft records, spacecraft launchings for 1980, and scientific payload anf probes launched 1975-1980. Budget data are included.

  10. ADVANCED POWER SYSTEMS - ASH BEHAVIOR IN POWER SYSTEMS. INCLUDES THE SEMIANNUAL REPORT FOR THE PERIOD JANUARY 01, 1998 - JUNE 30, 1998.

    SciTech Connect

    1998-09-01

    The overall goal of this initiative is to develop fundamental knowledge of ash behavior in power systems for the purpose of increasing power production efficiency, reducing operation and maintenance costs, and reducing greenhouse gas emissions into the atmosphere. The specific objectives of this initiative focus primarily on ash behavior related to advanced power systems and include the following: Determine the current status of the fundamental ash interactions and deposition formation mechanisms as already reported through previous or ongoing projects at the EERC or in the literature; Determine sintering mechanisms for temperatures and particle compositions that are less well known and remain for the most part undetermined; Identify the relationship between the temperature of critical viscosity (T{sub cv}) as measured in a viscometer and the crystallization occurring in the melt; Perform a literature search on the use of heated-stage microscopy (HSM) for examining in situ ash-sintering phenomena and then validate the use of HSM in the determination of viscosity in spherical ash particles; Ascertain the formation and stability of specific mineral or amorphous phases in deposits typical of advanced power systems; and Evaluate corrosion for alloys being used in supercritical combustion systems.

  11. Wetland Biomass Production: emergent aquatic management options and evaluations. A final subcontract report. [Includes a bibliography containing 686 references on Typha from biological abstracts

    SciTech Connect

    Pratt, D.C.; Dubbe, D.R.; Garver, E.G.; Linton, P.J.

    1984-07-01

    The high yield potential and attractive chemical composition of Typha make it a particularly viable energy crop. The Minnesota research effort has demonstrated that total annual biomass yields equivalent to 30 dry tonnes/ha (13 tons/acre) are possible in planted stands. This compares with yields of total plant material between 9 and 16 dry tonnes/ha (4 to 7 tons/acre) in a typical Minnesota corn field. At least 50% of the Typha plant is comprised of a belowground rhizome system containing 40% starch and sugar. This high level of easily fermentable carbohydrate makes rhizomes an attractive feedstock for alcohol production. The aboveground portion of the plant is largely cellulose, and although it is not easily fermentable, it can be gasified or burned. This report is organized in a manner that focuses on the evaluation of the management options task. Results from stand management research performed at the University of Minnesota during 1982 and 1983 are integrated with findings from an extensive survey of relevant emergent aquatic plant research and utilization. These results and findings are then arranged in sections dealing with key steps and issues that need to be dealt with in the development of a managed emergent aquatic bio-energy system. A brief section evaluating the current status of rhizome harvesting is also included along with an indexed bibliography of the biology, ecology, and utilization of Typha which was completed with support from this SERI subcontract. 686 references, 11 figures, 17 tables.

  12. In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin.

    PubMed

    Endimiani, Andrea; Patel, Gopi; Hujer, Kristine M; Swaminathan, Mahesh; Perez, Federico; Rice, Louis B; Jacobs, Michael R; Bonomo, Robert A

    2010-01-01

    In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC(50/90) of 16/64 microg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC(50/90) of 32/128 microg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.

  13. Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis.

    PubMed

    Phillips, Joshua B; Smith, Adrienne E; Kusche, Brian R; Bessette, Bradley A; Swain, P Whitney; Bergmeier, Stephen C; McMills, Mark C; Wright, Dennis L; Priestley, Nigel D

    2010-10-01

    We have shown that the intentional engineering of a natural product biosynthesis pathway is a useful way to generate stereochemically complex scaffolds for use in the generation of combinatorial libraries that capture the structural features of both natural products and synthetic compounds. Analysis of a prototype library based upon nonactic acid lead to the discovery of triazole-containing nonactic acid analogs, a new structural class of antibiotic that exhibits bactericidal activity against drug resistant, Gram-positive pathogens including Staphylococcus aureus and Enterococcus faecalis.

  14. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  15. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  16. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  17. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  18. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  19. Advanced Light Source activity report 1996/97

    SciTech Connect

    1997-09-01

    Ten years ago, the Advanced Light Source (ALS) existed as a set of drawings, calculations, and ideas. Four years ago, it stored an electron beam for the first time. Today, the ALS has moved from those ideas and beginnings to a robust, third-generation synchrotron user facility, with eighteen beam lines in use, many more in planning or construction phases, and hundreds of users from around the world. Progress from concepts to realities is continuous as the scientific program, already strong in many diverse areas, moves in new directions to meet the needs of researchers into the next century. ALS staff members who develop and maintain the infrastructure for this research are similarly unwilling to rest on their laurels. As a result, the quality of the photon beams the authors deliver, as well as the support they provide to users, continues to improve. The ALS Activity Report is designed to share the results of these efforts in an accessible form for a broad audience. The Scientific Program section, while not comprehensive, shares the breadth, variety, and interest of recent research at the ALS. (The Compendium of User Abstracts and Technical Reports provides a more comprehensive and more technical view.) The Facility Report highlights progress in operations, ongoing accelerator research and development, and beamline instrumentation efforts. Although these Activity Report sections are separate, in practice the achievements of staff and users at the ALS are inseparable. User-staff collaboration is essential as they strive to meet the needs of the user community and to continue the ALS's success as a premier research facility.

  20. Kinetic Structure of Large-Conductance Ca2+-activated K+ Channels Suggests that the Gating Includes Transitions through Intermediate or Secondary States

    PubMed Central

    Rothberg, Brad S.; Magleby, Karl L.

    1998-01-01

    Mechanisms for the Ca2+-dependent gating of single large-conductance Ca2+-activated K+ channels from cultured rat skeletal muscle were developed using two-dimensional analysis of single-channel currents recorded with the patch clamp technique. To extract and display the essential kinetic information, the kinetic structure, from the single channel currents, adjacent open and closed intervals were binned as pairs and plotted as two-dimensional dwell-time distributions, and the excesses and deficits of the interval pairs over that expected for independent pairing were plotted as dependency plots. The basic features of the kinetic structure were generally the same among single large-conductance Ca2+-activated K+ channels, but channel-specific differences were readily apparent, suggesting heterogeneities in the gating. Simple gating schemes drawn from the Monod- Wyman-Changeux (MWC) model for allosteric proteins could approximate the basic features of the Ca2+ dependence of the kinetic structure. However, consistent differences between the observed and predicted dependency plots suggested that additional brief lifetime closed states not included in MWC-type models were involved in the gating. Adding these additional brief closed states to the MWC-type models, either beyond the activation pathway (secondary closed states) or within the activation pathway (intermediate closed states), improved the description of the Ca2+ dependence of the kinetic structure. Secondary closed states are consistent with the closing of secondary gates or channel block. Intermediate closed states are consistent with mechanisms in which the channel activates by passing through a series of intermediate conformations between the more stable open and closed states. It is the added secondary or intermediate closed states that give rise to the majority of the brief closings (flickers) in the gating. PMID:9607935

  1. Evaluating Greenhouse Gas Emissions Reporting Systems for Agricultural Waste Burning Using MODIS Active Fires

    NASA Astrophysics Data System (ADS)

    Lin, H.; Jin, Y.; Giglio, L.; Foley, J. A.; Randerson, J. T.

    2010-12-01

    Fires in agricultural ecosystems emit greenhouse gases and aerosols that influence climate on multiple spatial and temporal scales. Annex 1 countries of the United Nations Framework Convention on Climate Change (UNFCCC), many of which ratified the Kyoto Protocol, are required to report emissions of CO2, CH4 and N2O from these fires annually. We evaluated several aspects of this reporting system, including the optimality of the crops targeted by the UNFCCC globally and within Annex 1 countries and the consistency of emissions reporting among countries. We also evaluated the success of the individual countries in capturing interannual variability and long-term trends in agricultural fire activity. We combined global crop maps with Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) active fire detections. At a global scale, we recommend adding ground nuts, cocoa, cotton and oil palm, and removing potato, oats, pulse other and rye from the UNFCCC list of 14 crops. This leads to an overall increase of 6% of the active fires covered by the reporting system. Optimization led to a different recommended list for Annex 1 countries. Extending emissions reporting to all Annex 1 countries (from the current set of 19 countries) would increase the efficacy of the reporting system from 10% to 20%, and further including several non-Annex 1 countries (Argentina, Brazil, China, India, Indonesia, Thailand, Kazakhstan, Mexico and Nigeria) would capture over 58% of active fires in croplands worldwide. Analyses of interannual trends from the U.S. and Australia showed the importance of both intensity of fire use and crop production in controlling year-to-year variations in agricultural fire emissions. Remote sensing provides an efficient tool for an independent assessment of current UNFCCC emissions reporting system; and, if combined with census data, field experiments and expert opinion, has the potential for improving the robustness of the next generation inventory

  2. Computer Science Research Institute 2005 annual report of activities.

    SciTech Connect

    Watts, Bernadette M.; Collis, Samuel Scott; Ceballos, Deanna Rose; Womble, David Eugene

    2008-04-01

    This report summarizes the activities of the Computer Science Research Institute (CSRI) at Sandia National Laboratories during the period January 1, 2005 to December 31, 2005. During this period, the CSRI hosted 182 visitors representing 83 universities, companies and laboratories. Of these, 60 were summer students or faculty. The CSRI partially sponsored 2 workshops and also organized and was the primary host for 3 workshops. These 3 CSRI sponsored workshops had 105 participants, 78 from universities, companies and laboratories, and 27 from Sandia. Finally, the CSRI sponsored 12 long-term collaborative research projects and 3 Sabbaticals.

  3. Computer Science Research Institute 2004 annual report of activities.

    SciTech Connect

    DeLap, Barbara J.; Womble, David Eugene; Ceballos, Deanna Rose

    2006-03-01

    This report summarizes the activities of the Computer Science Research Institute (CSRI) at Sandia National Laboratories during the period January 1, 2004 to December 31, 2004. During this period the CSRI hosted 166 visitors representing 81 universities, companies and laboratories. Of these 65 were summer students or faculty. The CSRI partially sponsored 2 workshops and also organized and was the primary host for 4 workshops. These 4 CSRI sponsored workshops had 140 participants--74 from universities, companies and laboratories, and 66 from Sandia. Finally, the CSRI sponsored 14 long-term collaborative research projects and 5 Sabbaticals.

  4. Reporting neural activity with genetically encoded calcium indicators

    PubMed Central

    Hires, S. Andrew; Tian, Lin; Looger, Loren L.

    2009-01-01

    Genetically encoded calcium indicators (GECIs), based on recombinant fluorescent proteins, have been engineered to observe calcium transients in living cells and organisms. Through observation of calcium, these indicators also report neural activity. We review progress in GECI construction and application, particularly toward in vivo monitoring of sparse action potentials (APs). We summarize the extrinsic and intrinsic factors that influence GECI performance. A simple model of GECI response to AP firing demonstrates the relative significance of these factors. We recommend a standardized protocol for evaluating GECIs in a physiologically relevant context. A potential method of simultaneous optical control and recording of neuronal circuits is presented. PMID:18941901

  5. Status report of CPHS and neutron activities at Tsinghua University

    NASA Astrophysics Data System (ADS)

    Wang, X.; Xing, Q.; Zheng, S.; Yang, Y.; Gong, H.; Xiao, Y.; Wu, H.; Guan, X.; Du, T.

    2016-11-01

    The Compact Pulsed Hadron Source (CPHS) project that was launched in September 2009 at Tsinghua University has reached a first commissioning stage in conjunction with ongoing activities to fulfill the eventual design goal of a ˜ 1013 n/s epithermal-to-cold neutron yield for education, instrumentation development, and industrial applications. Here, we report the latest progress on the commissioning and applications of 3MeV proton and neutron beam lines in the last one and half years, and the design, fabrication, engineering of the 13MeV/16kW proton accelerator system.

  6. Computer Science Research Institute 2003 annual report of activities.

    SciTech Connect

    DeLap, Barbara J.; Womble, David Eugene; Ceballos, Deanna Rose

    2006-03-01

    This report summarizes the activities of the Computer Science Research Institute (CSRI) at Sandia National Laboratories during the period January 1, 2003 to December 31, 2003. During this period the CSRI hosted 164 visitors representing 78 universities, companies and laboratories. Of these 78 were summer students or faculty members. The CSRI partially sponsored 5 workshops and also organized and was the primary host for 3 workshops. These 3 CSRI sponsored workshops had 178 participants--137 from universities, companies and laboratories, and 41 from Sandia. Finally, the CSRI sponsored 18 long-term collaborative research projects and 5 Sabbaticals.

  7. FY15 Status Report on NEAMS Neutronics Activities

    SciTech Connect

    Lee, C. H.; Shemon, E. R.; Smith, M. A.; Connaway, H. M.; Aliberti, G.

    2015-09-30

    This report summarizes the current status of NEAMS activities in FY2015. The tasks this year are (1) to improve solution methods for steady-state and transient conditions, (2) to develop features and user friendliness to increase the usability and applicability of the code, (3) to improve and verify the multigroup cross section generation scheme, (4) to perform verification and validation tests of the code using SFRs and thermal reactor cores, and (5) to support early users of PROTEUS and update the user manuals.

  8. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates

    PubMed Central

    Pfaller, Michael A.; Messer, Shawn A.; Rhomberg, Paul R.; Jones, Ronald N.; Castanheira, Mariana

    2016-01-01

    Objectives The objective of this study was to evaluate the in vitro activity of CD101, a novel echinocandin with a long serum elimination half-life, and comparator (anidulafungin and caspofungin) antifungal agents against a collection of Candida and Aspergillus spp. isolates. Methods CD101 and comparator agents were tested against 106 Candida spp. and 67 Aspergillus spp. isolates, including 27 isolates of Candida harbouring fks hotspot mutations and 12 itraconazole non-WT Aspergillus, using CLSI and EUCAST reference susceptibility broth microdilution (BMD) methods. Results Against WT and fks mutant Candida albicans, Candida glabrata and Candida tropicalis, the activity of CD101 [MIC90 = 0.06, 0.12 and 0.03 mg/L, respectively (CLSI method values)] was comparable to that of anidulafungin (MIC90 = 0.03, 0.12 and 0.03 mg/L, respectively) and caspofungin (MIC90 = 0.12, 0.25 and 0.12 mg/L, respectively). WT Candida krusei isolates were very susceptible to CD101 (MIC = 0.06 mg/L). CD101 activity (MIC50/90 = 1/2 mg/L) was comparable to that of anidulafungin (MIC50/90 = 2/2 mg/L) against Candida parapsilosis. CD101 (MIC mode = 0.06 mg/L for C. glabrata) was 2- to 4-fold more active against fks hotspot mutants than caspofungin (MIC mode = 0.5 mg/L). CD101 was active against Aspergillus fumigatus, Aspergillus terreus, Aspergillus niger and Aspergillus flavus (MEC90 range = ≤0.008–0.03 mg/L). The essential agreement between CLSI and EUCAST methods for CD101 was 92.0%–100.0% among Candida spp. and 95.0%–100.0% among Aspergillus spp. Conclusions The activity of CD101 is comparable to that of other members of the echinocandin class for the prevention and treatment of serious fungal infections. Similar results for CD101 activity versus Candida and Aspergillus spp. may be obtained with either CLSI or EUCAST BMD methods. PMID:27287236

  9. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

    PubMed Central

    Zhang, W; Doherty, M; Arden, N; Bannwarth, B; Bijlsma, J; Gunther, K; Hauselmann, H; Herrero-Beaumont, G; Jordan, K; Kaklamanis, P; Leeb, B; Lequesne, M; Lohmander, S; Mazieres, B; Martin-Mola, E; Pavelka, K; Pendleton, A; Punzi, L; Swoboda, B; Varatojo, R; Verbruggen, G; Zimmermann-Gorska, I; Dougados, M

    2005-01-01

    Objective: To develop evidence based recommendations for the management of hip osteoarthritis (OA). Methods: The multidisciplinary guideline development group comprised 18 rheumatologists, 4 orthopaedic surgeons, and 1 epidemiologist, representing 14 European countries. Each participant contributed up to 10 propositions describing key clinical aspects of hip OA management. Ten final recommendations were agreed using a Delphi consensus approach. Medline, Embase, CINAHL, Cochrane Library, and HTA reports were searched systematically to obtain research evidence for each proposition. Where possible, outcome data for efficacy, adverse effects, and cost effectiveness were abstracted. Effect size, rate ratio, number needed to treat, and incremental cost effectiveness ratio were calculated. The quality of evidence was categorised according to the evidence hierarchy. The strength of recommendation was assessed using the traditional A–D grading scale and a visual analogue scale. Results: Ten key treatment propositions were generated through three Delphi rounds. They included 21 interventions, such as paracetamol, NSAIDs, symptomatic slow acting disease modifying drugs, opioids, intra-articular steroids, non-pharmacological treatment, total hip replacement, osteotomy, and two general propositions. 461 studies were identified from the literature search for the proposed interventions of efficacy, side effects, and cost effectiveness. Research evidence supported 15 interventions in the treatment of hip OA. Evidence specific for the hip was strikingly lacking. Strength of recommendation varied according to category of research evidence and expert opinion. Conclusion: Ten key recommendations for the treatment of hip OA were developed based on research evidence and expert consensus. The effectiveness and cost effectiveness of these recommendations were evaluated and the strength of recommendation was scored. PMID:15471891

  10. EULAR evidence based recommendations for the management of hand osteoarthritis: Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

    PubMed Central

    Zhang, W; Doherty, M; Leeb, B F; Alekseeva, L; Arden, N K; Bijlsma, J W; Dinçer, F; Dziedzic, K; Häuselmann, H J; Herrero‐Beaumont, G; Kaklamanis, P; Lohmander, S; Maheu, E; Martín‐Mola, E; Pavelka, K; Punzi, L; Reiter, S; Sautner, J; Smolen, J; Verbruggen, G; Zimmermann‐Górska, I

    2007-01-01

    Objectives To develop evidence based recommendations for the management of hand osteoarthritis (OA). Methods The multidisciplinary guideline development group comprised 16 rheumatologists, one physiatrist, one orthopaedic surgeon, two allied health professionals, and one evidence based medicine expert, representing 15 different European countries. Each participant contributed up to 10 propositions describing key clinical points for management of hand OA. Final recommendations were agreed using a Delphi consensus approach. A systematic search of Medline, Embase, CINAHL, Science Citation Index, AMED, Cochrane Library, HTA, and NICE reports was used to identify the best available research evidence to support each proposition. Where possible, the effect size and number needed to treat were calculated for efficacy. Relative risk or odds ratio was estimated for safety, and incremental cost effectiveness ratio was used for cost effectiveness. The strength of recommendation was provided according to research evidence, clinical expertise, and perceived patient preference. Results Eleven key propositions involving 17 treatment modalities were generated through three Delphi rounds. Treatment topics included general considerations (for example, clinical features, risk factors, comorbidities), non‐pharmacological (for example, education plus exercise, local heat, and splint), pharmacological (for example, paracetamol, NSAIDs, NSAIDs plus gastroprotective agents, COX‐2 inhibitors, systemic slow acting disease modifying drugs, intra‐articular corticosteroids), and surgery. Of 17 treatment modalities, only six were supported by research evidence (education plus exercise, NSAIDs, COX‐2 inhibitors, topical NSAIDs, topical capsaicin, and chondroitin sulphate). Others were supported either by evidence extrapolated from studies of OA affecting other joint sites or by expert opinion. Strength of recommendation varied according to level of evidence, benefits and harms/costs of

  11. Summary of BISON Development Activities: NEAMS FY14 Report

    SciTech Connect

    Williamson, R. L.; Novascone, S. R.; Hales, J. D.; Spencer, B. W.; Liu, W.; Pastore, G.; Perez, D. M.; Gardner, R. J.; Stafford, D. S.; Gamble, K. A.

    2014-10-01

    This summary report contains an overview of work performed under the work package entitled “FY2014 NEAMS INL-Engineering Scale Fuel Performance & Interface with RPL Tools.” A first chapter identifies the specific FY-14 milestones, providing a basic description of the associated work and references to related detailed documentation. Where applicable, a representative technical result is provided. A second chapter summarizes substantial additional work including 1) efforts to improve numerical convergence and contact in BISON, 2) development of capability to simulate hydrogen behavior in Zircaloy cladding and 3) efforts to enhance collaborative work with the Halden Research Program. A final chapter briefly outlines planned future work.

  12. Stages of change for physical activity and dietary habits in persons with type 2 diabetes included in a mobile health intervention: the Norwegian study in RENEWING HEALTH

    PubMed Central

    Holmen, Heidi; Wahl, Astrid; Torbjørnsen, Astrid; Jenum, Anne Karen; Småstuen, Milada Cvancarova; Ribu, Lis

    2016-01-01

    Objective The aim of this study was to investigate stages of change for physical activity and dietary habits using baseline data from persons with type 2 diabetes included in a mobile health intervention. We examined the associations between stages of change for physical activity change and dietary change, and between stages of change for each behavior and individual characteristics, health-related quality of life, self-management, depressive symptoms, and lifestyle. Research design and methods We examined 151 persons with type 2 diabetes with an glycated hemoglobin (HbA1c) level ≥7.1%, aged ≥18 years at baseline of a randomized controlled trial, before testing a mobile app with or without health counseling. Stages of change were dichotomized into ‘pre-action’ and ‘action’. Self-management was measured using the Health Education Impact Questionnaire (heiQ) where a higher score reflects increased self-management, and health-related quality of life was measured with the Short-Form-36 (SF-36). Logistic regression modeling was performed. Results The median HbA1c level was 7.9% (7.1–12.4), 90% were overweight or obese, and 20% had ≥3 comorbidities. 58% were in the preaction stage for physical activity change and 79% in the preaction stage for dietary change. Higher scores of self-management were associated with an increased chance of being in the action stage for both dietary change and physical activity change. Higher body mass index was associated with an 8% reduced chance of being in the action stage for physical activity change (OR 0.92, 95% CI 0.86 to 0.99). Conclusions Being in the action stage was associated with higher scores of self-management, crucial for type 2 diabetes. Over half of the participants were in the preaction stage for physical activity and dietary change, and many had a high disease burden with comorbidities and overweight. Trial registration number NCT01315756. PMID:27239317

  13. Stanford Synchrotron Radiation Laboratory activity report for 1987

    SciTech Connect

    Robinson, S.; Cantwell, K.

    1988-12-31

    During 1987, SSRL achieved many significant advances and reached several major milestones utilizing both SPEAR and PEP as synchrotron radiation sources as described in this report. Perhaps the following two are worthy of particular mention: (1) SPEAR reached an all time high of 4,190 delivered user-shifts during calendar year 1987, highlights of the many scientific results are given; (2) during a 12 day run in December of 1987, PEP was operated in a low emittance mode (calculated emittance 6.4 nanometer-radians) at 7.1 GeV with currents up to 33 mA. A second undulator beam line on PEP was commissioned during this run and used to record many spectra showing the extremely high brightness of the radiation. PEP is now by far the highest brightness synchrotron radiation source in the world. The report is divided into the following sections: (1) laboratory operations; (2) accelerator physics programs; (3) experimental facilities; (4) engineering division; (5) conferences and workshops; (6) SSRL organization; (7) experimental progress reports; (8) active proposals; (9) SSRL experiments and proposals by institution; and (10) SSRL publications.

  14. Update of the BIPM comparison BIPM.RI(II)-K1.Sr-85 of activity measurements of the radionuclide 85Sr to include the 2009 result of the POLATOM (Poland)

    NASA Astrophysics Data System (ADS)

    Michotte, C.; Ratel, G.; Courte, S.; Dziel, T.; Listkowska, A.

    2015-01-01

    Since 1975, ten laboratories have submitted 27 samples of known activity of 85Sr to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Sr-85. The values of the activity submitted were between about 0.2 MBq and 19 MBq. The key comparison reference value (KCRV) has been recalculated to include the primary standardization result for the POLATOM, Poland. There are now four results in the BIPM.RI(II)-K1.Sr-85 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  15. A Comparison of Brunt Criteria, the Non Alcoholic Fatty Liver Disease Activity Score (NAS) & a Proposed NAS-including fibrosis as Valid Diagnostic Scores for NASH

    PubMed Central

    Santiago-Rolón, Amarilys; Purcell, Dagmary; Rosado, Kathia; Toro, Doris H.

    2016-01-01

    Objective Non-alcoholic steatohepatitis (NASH) can result in cirrhosis and end stage liver disease. It is of utmost importance to differentiate NASH from simple steatosis. The aim of this study is to determine the prevalence of NASH in Latino veterans with metabolic syndrome and compare histologic grading using Brunt Criteria, the NAFLD activity score (NAS), and a proposed NAS score including fibrosis. Methods Veterans with metabolic syndrome, hepatic steatosis and elevation of ALT/AST who underwent a liver biopsy from 2004-2010 were included in this study. Biopsies were evaluated by a single blinded Hepatopathologist. Steatosis, lobular inflammation, ballooning and fibrosis were graded per specimen. Each biopsy was evaluated using Brunt criteria, NAS and NAS plus fibrosis. Results Sixty patients were included in this study, 88.3% men with a mean age of 50.4 (± 12.8). 50.0% met criteria for NASH according to the Brunt system. When classifying biopsies using NAS, only 30.0% (18/60) had a score ≥5, while when adding fibrosis, the number of patients with a score ≥5 increased to 33 (55.0%). When evaluating the predictive ability of the two scoring systems, we found that NAS including fibrosis had a higher sensitivity than NAS (86.7% vs. 40.0%) and a lower specificity (76.7% vs. 80.0%). Conclusion In our population with metabolic syndrome and altered liver function tests, about 50-55% had steatohepatitis. There were significant differences between the scoring systems. When using NAS-plus-fibrosis more patients were recognized and the sensitivity increased. Further validation studies are required to evaluate this proposed NAS scoring System. PMID:26602577

  16. Aeronautics and space report of the President, 1983 activities

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Achievements in communication; space science; space transportation; aeronautics; and Earth resources and environment are summarized. Activities of the various Federal agencies and cooperation with NASA in these areas are described. The Presidential policy announcement on the endorsement of commercial operation of expendable launch vehicles is included. Tables show, the space activities budget; a historical budget summary, U.S. space launch vehicles; U.S. and Soviet manned spaceflights, 1961 to 1983; U.S. launched space probes, 1975 to 1983; U.S. launched scientific and applications satellites, 1978 to 1983; the U.S. spacecraft record; the world record of space launches successful in attaining Earth orbit or beyond; and successful U.S. launchings for 1983.

  17. Report of activities performed, July 1, 1980-June 30, 1981

    SciTech Connect

    Not Available

    1981-01-01

    The Numerical Data Advisory Board (NDAB) is a body within the National Research Council composed of a general board with specialized committees and panels. The objective of NDAB and its committees and panels is the improvement in quality, reliability, availability, accessibility, dissemination, utilization, and management of data. NDAB seeks to promote an appreciation of the importance of evaluated data to scientists, engineers, regulators, and others who require reliable numerical data for research and for decision making. NDAB is an interdisciplinary body with representation from physical, chemical, engineering, biological, and geological sciences. Selected sociotechnical, socioeconomic, and transient, or soft data topics are also covered. An effective path of communication with international data activities is maintained by scheduling NDAB meetings jointly with the US National Committee for CODATA, the Committee on Data for Science and Technology of the International Council for Scientific Unions (ICSU). An active government liaison relationship is maintained to facilitate input from, and discussion with branches of agencies that deal with technical data and information programs. NDAB has addressed both broad, generic cross-cutting data problems pertinent to all agencies that support R and D programs, as well as specific issues. For some of the specific topics, ad hoc meetings with subgroups of NDAB and the specific agencies requesting such discussions were held. Meetings held by NDAB for the time period covered by this report, as well as other activities, are summarized in Attachment A.

  18. DDE-MURR Status Report of Conceptual Design Activities

    SciTech Connect

    N.E. Woolstenhulme; R.B. Nielson; M.H. Sprenger; G.K. Housley

    2013-09-01

    The Design Demonstration Experiment for the University of Missouri Research Reactor (DDE-MURR) is intended to facilitate Low Enriched Uranium (LEU) conversion of the MURR by demonstrating the performance and fabrication of the LEU fuel element design through an irradiation test in a 200mm channel at the Belgium Reactor 2 (BR2). Revision 0 of this report was prepared at the end of government fiscal year 2012 when most of the resources for furthering DDE design work were expected to be postponed. Hence, the conceptual design efforts were summarized to provide the status of key objectives, notable results, and provisions for future design work. Revision 1 of this report was prepared at the end of fiscal year 2013 in order to include results from a neutronic study performed by BR2, to incorporate further details that had been achieved in the engineering sketches of the irradiation devices, and to provide an update of the DDE-MURR campaign in relation to program objectives and opportunities for its eventual irradiation. These updates were purposed to bring the DDE-MURR conceptual design to level of maturity similar to that of the other two DDE efforts (DDE-MITR and DDE-NBSR). This report demonstrates that the DDE-MURR design effort is well on the path to producing a suitable irradiation experiment, but also puts forth several recommendations in order to facilitate success of the irradiation campaign.

  19. Launch Deployment Assembly Extravehicular Activity Neutral Buoyancy Development Test Report

    NASA Technical Reports Server (NTRS)

    Loughead, T.

    1996-01-01

    This test evaluated the Launch Deployment Assembly (LDA) design for Extravehicular Activity (EVA) work sites (setup, igress, egress), reach and visual access, and translation required for cargo item removal. As part of the LDA design, this document describes the method and results of the LDA EVA Neutral Buoyancy Development Test to ensure that the LDA hardware support the deployment of the cargo items from the pallet. This document includes the test objectives, flight and mockup hardware description, descriptions of procedures and data collection used in the testing, and the results of the development test at the National Aeronautics and Space Administrations (NASA) Marshall Space Flight Center (MSFC) Neutral Buoyancy Simulator (NBS).

  20. Aeronautics and space report of the President, 1982 activities

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Achievements of the space program are summerized in the area of communication, Earth resources, environment, space sciences, transportation, aeronautics, and space energy. Space program activities of the various deprtments and agencies of the Federal Government are discussed in relation to the agencies' goals and policies. Records of U.S. and world spacecraft launchings, successful U.S. launches for 1982, U.S. launched applications and scientific satellites and space probes since 1975, U.S. and Soviet manned spaceflights since 1961, data on U.S. space launch vehicles, and budget summaries are provided. The national space policy and the aeronautical research and technology policy statements are included.

  1. Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

    PubMed Central

    Brimson, James M.; Brimson, Sirikalaya J.; Brimson, Christopher A.; Rakkhitawatthana, Varaporn; Tencomnao, Tewin

    2012-01-01

    The Herb Rhinacanthus nasutus (L.) Kurz, which is native to Thailand and Southeast Asia, has become known for its antioxidant properties. Neuronal loss in a number of diseases including Alzheimer’s disease is thought to result, in part, from oxidative stress. Glutamate causes cell death in the mouse hippocampal cell line, HT-22, by unbalancing redox homeostasis, brought about by a reduction in glutathione levels, and amyloid-β has been shown to induce reactive oxygen species (ROS) production. Here in, we show that ethanol extracts of R. nasutus leaf and root are capable of dose dependently attenuating the neuron cell death caused by both glutamate and amyloid-β treatment. We used free radical scavenging assays to measure the extracts antioxidant activities and as well as quantifying phenolic, flavonoid and sterol content. Molecules found in R. nasutus, lupeol, stigmasterol and β-sitosterol are protective against glutamate toxicity. PMID:22606031

  2. Implications of Public Reporting of Risk-Adjusted Mortality Following Percutaneous Coronary Intervention: Misperceptions and Potential Consequences for High-Risk Patients Including Nonsurgical Patients.

    PubMed

    Gupta, Anuj; Yeh, Robert W; Tamis-Holland, Jacqueline E; Patel, Shalin H; Guyton, Robert A; Klein, Lloyd W; Rab, Tanveer; Kirtane, Ajay J

    2016-10-24

    Assessment of clinical outcomes such as 30-day mortality following coronary revascularization procedures has historically been used to spur quality improvement programs. Public reporting of risk-adjusted outcomes is already mandated in several states, and proposals to further expand public reporting have been put forward as a means of increasing transparency and potentially incentivizing high quality care. However, for public reporting of outcomes to be considered a useful surrogate of procedural quality of care, several prerequisites must be met. First, the reporting measure must be truly representative of the quality of the procedure itself, rather than be dominated by other underlying factors, such as the overall level of illness of a patient. Second, to foster comparisons among physicians and institutions, the metric requires accurate ascertainment of and adjustment for differences in patient risk profiles. This is particularly relevant for high-risk clinical patient scenarios. Finally, the potential deleterious consequences of public reporting of a quality metric should be considered prior to expanding the use of public reporting more broadly. In this viewpoint, the authors review in particular the characterization of high-risk patients currently treated by percutaneous coronary interventional procedures, assessing the adequacy of clinical risk models used in this population. They then expand upon the limitations of 30-day mortality as a quality metric for percutaneous coronary intervention, addressing the strengths and limitations of this metric, as well as offering suggestions to enhance its future use in public reporting.

  3. Establishment of reference intervals for kaolin-activated thromboelastography in dogs including an assessment of the effects of sex and anticoagulant use.

    PubMed

    Bauer, Natali; Eralp, Oya; Moritz, Andreas

    2009-09-01

    Tissue factor (TF)- and kaolin-activated thromboelastography (TEG) have been performed in a small number of healthy dogs, but reference intervals have not been assessed in a larger number of dogs. The goal of the current study was to establish reference intervals and assess intra-assay repeatability for kaolin-activated TEG in dogs. Additionally, the impact of sex and the influence of anticoagulant (native blood vs. recalcified citrate anticoagulated blood) were evaluated. Thromboelastography analyses were performed in 56 healthy dogs including German Shepherd Dogs (n = 19), Beagles (n = 15), and others (n = 22). Median age was 2 years (range: 1-6 years) and sex was evenly distributed (31 males and 25 females). To establish reference intervals, citrated whole-blood samples were collected, and TEG was performed 1 hr after sampling. Five TEG variables (R = reaction time; K = clot formation time; alpha = angle alpha; MA = maximal amplitude; G-value reflecting clot stability) were evaluated, and reference intervals were defined as the mean +/- 1.96-fold standard deviation. Intra-assay repeatability was assessed by calculating the pooled variance estimate in duplicate measurements of 6 healthy dogs. The effect of anticoagulant was assessed in 17 specimens. Reference intervals were as follows: R = 1.8-8.6 min; angle alpha = 36.9-74.6 degrees; K = 1.3-5.7 min; MA = 42.9-67.9 mm, and G = 3.2-9.6 Kdyn/cm(2). Coefficients of variation for R, K, angle alpha, MA, and G were 7.6%, 17.7%, 7.4%, 2.9%, and 6.6%, respectively. There was no significant impact of sex or anticoagulant on results. Interindividual variation was higher in native samples than in citrated whole blood. A limitation of the current study was that most of the samples were obtained from Beagles and German Shepherd Dogs. This study provides useful reference intervals for kaolin-activated TEG.

  4. Additional guidance for including nuclear safety equivalency in the Canister Storage Building and Cold Vacuum Drying Facility final safety analysis report

    SciTech Connect

    Garvin, L.J.

    1997-05-20

    This document provides guidance for the production of safety analysis reports that must meet both DOE Order 5480.23 and STD 3009, and be in compliance with the DOE regulatory policy that imposes certain NRC requirements.

  5. Physical activity by self-report: a brief history and future issues.

    PubMed

    Haskell, William L

    2012-01-01

    For the scientific domain of physical activity and public health research to advance its agenda of health promotion and disease prevention continued development of measurement methodologies is essential. Over the past 50 years most data supporting a favorable relationship between habitual physical activity and chronic disease morbidity and mortality have been obtained using self-report methods, including questionnaires, logs, recalls, and diaries. Many of these instruments have been shown to have reasonable validity and reliability for determining general type, amount, intensity, and bout duration, but typically do better for groups than individuals with some instruments lacking the sensitivity to detect change in activity. During the past decade the objective assessment of physical activity using accelerometer-based devices has demonstrated substantial potential, especially in documenting the pattern of light-, moderate-, and vigorous-intensity activity throughout the day. However, these devices do not provide information on activity type, location or context. Research that combines the strengths of both self-report and objective measures has the potential to provide new insights into the benefits of physical activity and how to implement successful interventions.

  6. PREFACE: 9th International Fröhlich's Symposium: Electrodynamic Activity of Living Cells (Including Microtubule Coherent Modes and Cancer Cell Physics)

    NASA Astrophysics Data System (ADS)

    Cifra, Michal; Pokorný, Jirí; Kucera, Ondrej

    2011-12-01

    This volume contains papers presented at the International Fröhlich's Symposium entitled 'Electrodynamic Activity of Living Cells' (1-3 July 2011, Prague, Czech Republic). The Symposium was the 9th meeting devoted to physical processes in living matter organized in Prague since 1987. The hypothesis of oscillation systems in living cells featured by non-linear interaction between elastic and electrical polarization fields, non-linear interactions between the system and the heat bath leading to energy downconversion along the frequency scale, energy condensation in the lowest frequency mode and creation of a coherent state was formulated by H Fröhlich, founder of the theory of dielectric materials. He assumed that biological activity is based not only on biochemical but also on biophysical mechanisms and that their disturbances form basic links along the cancer transformation pathway. Fröhlich outlined general ideas of non-linear physical processes in biological systems. The downconversion and the elastic-polarization interactions should be connected in a unified theory and the solution based on comprehensive non-linear characteristics. Biochemical and genetic research of biological systems are highly developed and have disclosed a variety of cellular and subcellular structures, chemical reactions, molecular information transfer, and genetic code sequences - including their pathological development. Nevertheless, the cancer problem is still a big challenge. Warburg's discovery of suppressed oxidative metabolism in mitochondria in cancer cells suggested the essential role of physical mechanisms (but his discovery has remained without impact on cancer research and on the study of physical properties of biological systems for a long time). Mitochondria, the power plants of the cell, have several areas of activity-oxidative energy production is connected with the formation of a strong static electric field around them, water ordering, and liberation of non

  7. Activities report of the Institute of Space Physics

    NASA Astrophysics Data System (ADS)

    Eliasson, Lars

    Activities at the Swedish Institute of Space Physics (IRF), whose main task is to conduct research and perform observatory measurements in the field of space physics, are addressed. Additionally, the IRF also provides education in space physics. Facts about the IRF and its board, staff, finances, and personnel are given. The research carried out in the four divisions is reviewed. The research covers the following topics: hot magnetospheric plasma investigations; research in the field of mechanical waves, especially concerning infrasound and vibration; space plasma theory, with an emphasis on plasma waves and wave particle interactions in the magnetosphere; experimental studies of waves and wave interactions in space plasmas; and electrodynamic processes related to ionosphere magnetosphere coupling. The observatory program which carried out ground based observations in Kiruna, Lycksele, and Uppsala (Sweden) is reviewed, as is the educational program. Committee appointments, participation in conferences and contributions, and publication and reports of 1991 are also addessed.

  8. ABB`s LEBS activities -- A status report

    SciTech Connect

    Regan, J.W.; Hein, R.J. von; Peletz, L.J. Jr.; Wesnor, J.D.; Bender, D.J.

    1996-12-31

    ABB Combustion Engineering, Inc. is one of three contractors executing Phases 1, 2 and 3 of the Department of Energy project entitled Engineering Development of Advanced Coal-Fired Low-Emission Boiler Systems (LEBS). Phase 1 has been completed and Phase 2 is scheduled for completion on September 30, 1996. The following major activities are being carried out in parallel in Phase 2 and this paper is a status report on this work: (1) in-furnace NOx reduction; (2) catalytic filter optimization; (3) add Kalina cycle to POCTF; and (4) POCTF design and licensing. The in-furnace NOx reduction work has been completed and, therefore, a description of this work comprises the major part of this paper.

  9. A fluorescent reporter of caspase activity for live imaging

    PubMed Central

    Bardet, Pierre-Luc; Kolahgar, Golnar; Mynett, Anita; Miguel-Aliaga, Irene; Briscoe, James; Meier, Pascal; Vincent, Jean-Paul

    2008-01-01

    There is a growing interest in the mechanisms that control the apoptosis cascade during development and adult life. To investigate the regulatory events that trigger apoptosis in whole tissues, we have devised a genetically encoded caspase sensor that can be detected in live and fixed tissue by standard confocal microscopy. The sensor comprises two fluorophores, mRFP, monomeric red fluorescent protein (mRFP) and enhanced green fluorescent protein (eGFP), that are linked by an efficient and specific caspase-sensitive site. Upon caspase activation, the sensor is cleaved and eGFP translocates to the nucleus, leaving mRFP at membranes. This is detected before other markers of apoptosis, including anti–cleaved caspase 3 immunoreactivity. Moreover, the sensor does not perturb normal developmental apoptosis and is specific, as cleavage does not occur in Drosophila embryos that are unable to activate the apoptotic cascade. Importantly, dying cells can be recognized in live embryos, thus opening the way for in vivo imaging. As expected from the high conservation of caspases, it is also cleaved in dying cells of chick embryos. It is therefore likely to be generally useful to track the spatiotemporal pattern of caspase activity in a variety of species. PMID:18779587

  10. Behavioral approach system activity and self-reported somatic symptoms in fibromyalgia: an exploratory study.

    PubMed

    Becerra-García, Juan A; Robles Jurado, Manuel J

    2014-01-01

    The first objective was to investigate the behavioural activity in the systems of Gray's theory; these are the Behavioural Inhibition System (BIS) and Behavioural Approach System (BAS), in fibromyalgia (FM) patients. The second aim was to assess in FM patients whether there is an association between BIS or BAS with self-reported somatic symptoms. Twenty FM patients and 20 healthy controls completed questionnaire measures of BIS and BAS activity (Sensitivity to Punishment and Sensitivity to Reward Questionnaire), self-reported somatic symptoms (Somatic Symptoms Scale Revised), positive and negative affect (Positive and Negative Affect Schedule) and health status (EuroQoL Visual Analogue Scale). The results showed that FM patients had lower Sensitivity to Reward (SR) scores than controls. The SR score correlated with different somatic symptoms groups. The partial correlation (controlling for other variables measured) showed that the SR score correlated specifically with musculoskeletal symptoms. Furthermore, in regression analysis, SR score significantly predicted musculoskeletal symptoms, after controlling for other variables measured in this study. Our findings suggest that FM patients show BAS hypoactivity. This BAS activity in FM is similar to patients with depression, where a lower BAS functioning has also been found. The BAS activity predicts the musculoskeletal self-reported symptoms in FM better than other measures included in this study. Although this is a preliminary study, it suggests the importance of BAS activity in FM.

  11. Development of a Reporter System for In Vivo Monitoring of γ-Secretase Activity in Drosophila

    PubMed Central

    Hong, Young Gi; Roh, Seyun; Paik, Donggi; Jeong, Sangyun

    2017-01-01

    The γ-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the β-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the γ-secretase catalytic component, presenilin, which lead to increased amyloid βpeptide production, are responsible for early-onset familial Alzheimer’s disease. β-amyloid protein precursor-like (APPL) is the Drosophila ortholog of human APP. Here, we created Notch- and APPL-based Drosophila reporter systems for in vivo monitoring of γ-secretase activity. Ectopic expression of the Notch- and APPL-based chimeric reporters in wings results in vein truncation phenotypes. Reporter-mediated vein truncation phenotypes are enhanced by the Notch gain-of-function allele and suppressed by RNAi-mediated knockdown of presenilin. Furthermore, we find that apoptosis partly contributes to the vein truncation phenotypes of the APPL-based reporter, but not to the vein truncation phenotypes of the Notch-based reporter. Taken together, these results suggest that both in vivo reporter systems provide a powerful genetic tool to identify genes that modulate γ-secretase activity and/or APPL metabolism. PMID:28152299

  12. Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex.

    PubMed

    Sui, Dexin; Xu, Xinjing; Ye, Xuemei; Liu, Mengyu; Mianecki, Maxwell; Rattanasinchai, Chotirat; Buehl, Christopher; Deng, Xiexiong; Kuo, Min-Hao

    2015-01-01

    Many biomedically critical proteins are underrepresented in proteomics and biochemical studies because of the difficulty of their production in Escherichia coli. These proteins might possess posttranslational modifications vital to their functions, tend to misfold and be partitioned into bacterial inclusion bodies, or act only in a stoichiometric dimeric complex. Successful production of these proteins requires efficient interaction between these proteins and a specific "facilitator," such as a protein-modifying enzyme, a molecular chaperone, or a natural physical partner within the dimeric complex. Here we report the design and application of a protein interaction module-assisted function X (PIMAX) system that effectively overcomes these hurdles. By fusing two proteins of interest to a pair of well-studied protein-protein interaction modules, we were able to potentiate the association of these two proteins, resulting in successful production of an enzymatically active cyclin-dependent kinase complex and hyperphosphorylated tau protein, which is intimately linked to Alzheimer disease. Furthermore, using tau isoforms quantitatively phosphorylated by GSK-3β and CDK5 kinases via PIMAX, we demonstrated the hyperphosphorylation-stimulated tau oligomerization in vitro, paving the way for new Alzheimer disease drug discoveries. Vectors for PIMAX can be easily modified to meet the needs of different applications. This approach thus provides a convenient and modular suite with broad implications for proteomics and biomedical research.

  13. Implementation of a comprehensive program including psycho-social and treatment literacy activities to improve adherence to HIV care and treatment for a pediatric population in Kenya

    PubMed Central

    Van Winghem, Joelle; Telfer, Barbara; Reid, Tony; Ouko, Judith; Mutunga, Angela; Jama, Zaina; Vakil, Shobha

    2008-01-01

    Background To achieve good clinical outcomes with HAART, patient adherence to treatment and care is a key factor. Since the literature on how to care for pediatric HIV patients is limited, we describe here adherence interventions implemented in our comprehensive care program in a resource-limited setting in Kenya. Methods We based our program on factors reported to influence adherence to HIV care and treatment. We describe, in detail, our program with respect to how we adapted our clinical settings, implemented psycho-social support activities for children and their caregivers and developed treatment literacy for children and teenagers living with HIV/AIDS. Results This paper focused on the details of the program, with the treatment outcomes as secondary. However, our program appeared to have been effective; for 648 children under 15 years of age who were started on HAART, the Kaplan-Meier mortality survival estimate was 95.27% (95%CI 93.16–96.74) at 12 months after the time of initiation of HAART. Conclusion Our model of pediatric HIV/AIDS care, focused on a child-centered approach with inclusion of caregivers and extended family, addressed the main factors influencing treatment adherence. It appeared to produce good results and is replicable in resource-limited settings. PMID:19025581

  14. Building Astronomy Curriculum to Include the Sight Impaired: Week long summer camp activities for Middle School Students adherent to Washington State Curriculum Standards (EALR's)

    NASA Astrophysics Data System (ADS)

    Ramien, Natalie; Loebman, S. R.; Player, V.; Larson, A.; Torcolini, N. B.; Traverse, A.

    2011-01-01

    Currently astronomy learning is heavily geared towards visual aids; however, roughly 10 million people in North America are sight impaired. Every student should have access to meaningful astronomy curriculum; an understanding of astronomy is an expectation of national and state science learning requirements. Over the last ten years, Noreen Grice has developed Braille and large print astronomy text books aimed at sight impaired learners. We build upon Grice's written work and present here a five day lesson plan that integrates 2D reading with 3D activities. Through this curriculum, students develop an intuitive understanding of astronomical distance, size, composition and lifetimes. We present five distinct lesson modules that can be taught individually or in a sequential form: the planets, our sun, stars, stellar evolution and galaxies. We have tested these modules on sight impaired students and report the results here. Overall, we find the work presented here lends itself equally well to a week long science camp geared toward middle school sight impaired taught by astronomers or as supplemental material integrated into a regular classroom science curriculum. This work was made possible by a 2007 Simple Effective Education and Dissemination (SEED) Grant For Astronomy Researchers, Astronomical Society of the Pacific through funds provided by the Planck Mission, Jet Propulsion Laboratory, California Institute of Technology.

  15. Status report on the survey and alignment activities at Fermilab

    SciTech Connect

    Oshinowo, Babatunde O'Sheg; /Fermilab

    2004-10-01

    The surveying and alignment activities at Fermilab are the responsibility of the Alignment and Metrology Group. The Group supports and interacts with physicists and engineers working on any particular project, from the facility construction phase to the installation and final alignment of components in the beam line. One of the goals of the Alignment and Metrology Group is to upgrade the old survey networks in the tunnel using modern surveying technology, such as the Laser Tracker for tunnel networks and GPS for the surface networks. According to the job needs, all surveys are done with Laser Trackers and/or Videogrammetry (V-STARS) systems for spatial coordinates; optical and electronic levels are used for elevations, Gyro-Theodolite for azimuths, Mekometer for distances and GPS for baseline vectors. The group has recently purchased two new API Laser Trackers, one INCA3 camera for the V-Stars, and one DNA03 digital level. This report presents the projects and major activities of the Alignment and Metrology Group at Fermilab during the period of 2000 to 2004. It focuses on the most important current projects, especially those that have to be completed during the currently scheduled three-month shutdown period. Future projects, in addition to the status of the current projects, are also presented.

  16. Active sites in char gasification: Final technical report

    SciTech Connect

    Wojtowicz, M.; Lilly, W.D.; Perkins, M.T.; Hradil, G.; Calo, J.M.; Suuberg, E.M.

    1987-09-01

    Among the key variables in the design of gasifiers and combustors is the reactivity of the chars which must be gasified or combusted. Significant loss of unburned char is unacceptable in virtually any process; the provision of sufficient residence time for complete conversion is essential. A very wide range of reactivities are observed, depending upon the nature of the char in a process. The current work focuses on furthering the understanding of gasification reactivities of chars. It has been well established that the reactivity of char to gasification generally depends upon three principal factors: (1) the concentration of ''active sites'' in the char; (2) mass transfer within the char; and (3) the type and concentration of catalytic impurities in the char. The present study primarily addresses the first factor. The subject of this research is the origin, nature, and fate of active sites in chars derived from parent hydrocarbons with coal-like structure. The nature and number of the active sites and their reactivity towards oxygen are examined in ''model'' chars derived from phenol-formaldehyde type resins. How the active sites are lost by the process of thermal annealing during heat treatment of chars are studied, and actual rate for the annealing process is derived. Since intrinsic char reactivities are of primary interest in the present study, a fair amount of attention was given to the model char synthesis and handling so that the effect of catalytic impurities and oxygen-containing functional groups in the chemical structure of the material were minimized, if not completely eliminated. The project would not be considered complete without comparing characteristic features of synthetic chars with kinetic behavior exhibited by natural chars, including coal chars.

  17. Are self-reported physical activity levels associated with perceived desirability of activity-friendly communities?

    PubMed

    Librett, John J; Yore, Michelle M; Schmid, Thomas L; Kohl, Harold W

    2007-09-01

    People living in activity-friendly communities (AFCs) are more active but the self-selection influence is unknown. From 4856 respondents we explored mediating variables with expressed desire to live in AFCs. Association with desire to live in AFCs included ages 18-24 years (odds ratio [OR]=1.9), African American (OR=1.9) or Hispanic (OR=1.5), and believing AFCs would support activity-based transportation (OR=2.4). Regular physical activity (PA) was marginally associated with desire to live in AFCs (OR=1.3). These findings suggest that PA may be a significant factor in communities of this style. Strategies for social marketing along with changes to the built environment to increase PA levels are discussed.

  18. A status report on a model for Benchmark active controls testing

    NASA Technical Reports Server (NTRS)

    Durham, Michael H.; Keller, Donald F.; Bennett, Robert M.; Wieseman, Carol D.

    1991-01-01

    This 'work-in-progress' paper presents a status report on an active controls flutter model which is currently in the design and fabrication phase. This model is a part of the Benchmark Models Program (BMP). The BMP is a NASA LaRC program that includes a series of models which will be used to study different aeroelastic phenomena and to validate aeroelastic methods. The objective of Benchmark Active Controls testing is to validate active control design tools. Flutter testing will be conducted with a pressure-instrumented rigid model attached to a flexible pitch and plunge mount system. Unsteady pressure distributions and transonic flutter boundaries will be measured with and without active control system engaged.

  19. Forecast for solar cycle 23 activity: a progress report

    NASA Astrophysics Data System (ADS)

    Ahluwalia, H. S.

    2001-08-01

    At the 25th International Cosmic Ray Conference (ICRC) at Durban, South Africa, I announced the discovery of a three cycle quasi-periodicity in the ion chamber data string assembled by me, for the 1937 to 1994 period (Conf. Pap., v. 2, p. 109, 1997). It corresponded in time with a similar quasi-periodicity observed in the dataset for the planetary index Ap. At the 26th ICRC at Salt Lake City, UT, I reported on our analysis of the Ap data to forecast the amplitude of solar cycle 23 activity (Conf. Pap., v. 2, pl. 260, 1999). I predicted that cycle 23 will be moderate (a la cycle 17), notwithstanding the early exuberant forecasts of some solar astronomers that cycle 23, "may be one of the greatest cycles in recent times, if not the greatest." Sunspot number data up to April 2001 indicate that our forecast appears to be right on the mark. We review the solar, interplanetary and geophysical data and describe the important lessons learned from this experience. 1. Introduction Ohl (1971) was the first to realize that Sun may be sending us a subliminal message as to its intent for its activity (Sunspot Numbers, SSN) in the next cycle. He posited that the message was embedded in the geomagnetic activity (given by sum Kp). Schatten at al (1978) suggested that Ohl hypothesis could be understood on the basis of the model proposed by Babcock (1961) who suggested that the high latitude solar poloidal fields, near a minimum, emerge as the toroidal fields on opposite sides of the solar equator. This is known as the Solar Dynamo Model. One can speculate that the precursor poloidal solar field is entrained in the high speed solar wind streams (HSSWS) from the coronal holes which are observed at Earth's orbit during the descending phase of the previous cycle. The interaction

  20. In vitro activity of ceftazidime/avibactam against Gram-negative pathogens isolated from pneumonia in hospitalised patients, including ventilated patients.

    PubMed

    Flamm, Robert K; Nichols, Wright W; Sader, Helio S; Farrell, David J; Jones, Ronald N

    2016-03-01

    The activities of the novel β-lactam/non-β-lactam β-lactamase inhibitor combination ceftazidime/avibactam and comparators were evaluated against isolates from pneumonia in hospitalised patients including ventilated patients (PHP, pneumonia not designated as VABP; VABP, pneumonia in ventilated patients). Isolates were from the European-Mediterranean region (EuM), China and the USA collected in the SENTRY Antimicrobial Surveillance Program between 2009 and 2011 inclusive. A total of 2393 organisms from PHP were from the EuM, 888 from China and 3213 from the USA; from VABP patients there were 918, 97 and 692 organisms collected, respectively. Among Enterobacteriaceae from PHP, ceftazidime/avibactam MIC90 values against Escherichia coli ranged from 0.25-0.5mg/L and Klebsiella spp. MIC90 values were 0.5mg/L in each region. Among VABP isolates, MIC90 values for ceftazidime/avibactam against E. coli were 0.25mg/L; for Klebsiella spp. from VABP patients, MIC90 values were similar to those obtained against PHP isolates. The MIC of ceftazidime/avibactam was ≤8mg/L against 92-96% of Pseudomonas aeruginosa isolated from PHP patients. Isolates of P. aeruginosa from VABP patients were of lower susceptibility to all antibacterial agents (e.g. depending on region, meropenem susceptibilities were 51.2-69.4% in contrast to 68.3-76.7% among PHP patients). However, ceftazidime/avibactam inhibited 79.2-95.4% of VABP isolates at an MIC of ≤8mg/L. Acinetobacter spp. were resistant to many agents and only rates of susceptibility to colistin were >90% across all regions both for PHP and VABP isolates. Ceftazidime/avibactam was generally active against a high proportion of isolates resistant to ceftazidime from PHP and VAPB patients.

  1. Recent Reform and Perspectives in Higher Education: Report of the Seminar Including a Range of Countries from Asia-Pacific and Europe.

    ERIC Educational Resources Information Center

    National Inst. for Educational Research, Tokyo (Japan).

    This report describes a 1998 seminar held to review the situation of higher education reform in Asia and the Pacific region, as well as in some Western nations, and to identify common issues and priorities, and then develop a collaborative framework for addressing these issues and setting priorities. Seventeen participants from 16 countries…

  2. Intergovernmental Oceanographic Commission Eleventh Session of the Assembly, Including Resolutions from the Tenth and Eleventh Sessions of the Executive Council, Paris, 15 October - 3 November 1979. Summary Report.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Intergovernmental Oceanographic Commission.

    The Intergovernmental Oceanographic Commission (IOC) functions within the United Nations Educational, Scientific, and Cultural Organization (Unesco) to promote scientific investigation into the nature and resources of the world's oceans. Summarized in this report are discussions that took place in both preparatory meetings and plenary sessions of…

  3. Preliminary Report on Floodplain Animals of the Upper Mississippi River and the Illinois Waterway Including Some Probable Impacts of Increased Commercial Traffic,

    DTIC Science & Technology

    1975-01-01

    al. (1975) and covers the central region of the present study area. In total, 529 species or subspecies occur including 37 amphibians, 89 reptiles...included. When more than one subspecies occurs in the study area, all are listed after the species name. Birds utilizing the un- protected floodplain...Birds (1957) and the 32nd Supplement (1973). In a few cases where ranges have not been adequately deline- ated for subspecies , Mengel (1965) is followed

  4. 1993 annual report of hazardous waste activities for the Oak Ridge K-25 site

    SciTech Connect

    Not Available

    1994-02-01

    This report is a detailed listing of all of the Hazardous Waste activities occurring at Martin Marietta`s K-25 site. Contained herein are hazardous waste notification forms, waste stream reports, generator fee forms and various TSDR reports.

  5. Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition.

    PubMed

    Gupta, Mamta; Gupta, Shiv Kumar; Hoffman, Barbara; Liebermann, Dan A

    2006-06-30

    Gadd45a, Gadd45b, and Gadd45g (Gadd45/MyD118/CR6) are genes that are rapidly induced by genotoxic stress and have been implicated in genotoxic stress-induced responses, notably in apoptosis. Recently, using myeloid-enriched bone marrow (BM) cells obtained from wild-type (WT), Gadd45a-deficient, and Gadd45b-deficient mice, we have shown that in hematopoietic cells Gadd45a and Gadd45b play a survival function to protect hematopoietic cells from DNA-damaging agents, including ultra violet (UV)-induced apoptosis. The present study was undertaken to decipher the molecular paths that mediate the survival functions of Gadd45a and Gadd45b against genotoxic stress induced by UV radiation. It is shown that in hematopoietic cells exposed to UV radiation Gaddd45a and Gadd45b cooperate to promote cell survival via two distinct signaling pathways involving activation of the GADD45a-p38-NF-kappaB-mediated survival pathway and GADD45b-mediated inhibition of the stress response MKK4-JNK pathway.

  6. 77 FR 75198 - Standard Format and Content for Post-Shutdown Decommissioning Activities Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... COMMISSION Standard Format and Content for Post-Shutdown Decommissioning Activities Report AGENCY: Nuclear... Format and Content for Post-shutdown Decommissioning Activities Report.'' This guide describes a method...) 1.185, ``Standard Format and Content for Post-shutdown Decommissioning Activities Report,''...

  7. Physical Activity and Self-Reported Cardiovascular Comorbidities in Persons with Multiple Sclerosis: Evidence from a Cross-Sectional Analysis

    PubMed Central

    Motl, Robert W.; Fernhall, Bo; McAuley, Edward; Cutter, Gary

    2011-01-01

    Background This study examined the possibility of a linear, inverse association between physical activity and the number of self-reported cardiovascular comorbidities in persons with multiple sclerosis (MS). Methods The sample included 561 persons with MS who completed demographic, cardiovascular comorbidity, disability status, and physical activity self-report assessments, and then wore an accelerometer for 7 days. The data were analyzed using bivariate correlation and multiple linear regression analyses. Results Bivariate correlation analysis indicated that there were statistically significant, inverse associations between the number of self-reported cardiovascular comorbidities and objectively measured (r = −0.192, p = 0.0001) and self-reported (r = −0.151, p = 0.0001) physical activity. The first multiple linear regression indicated that objectively measured physical activity was significantly associated with the number of self-reported cardiovascular comorbidities (B = −0.003, SE B = 0.001, β = −0.128), even after controlling for confounding variables. The second multiple linear regression indicated that self-reported physical activity, too, was significantly associated with the number of self-reported cardiovascular comorbidities (B = −0.011, SE B = 0.004, β = −0.114), even after controlling for confounding variables. Conclusion Physical activity was associated with the number of self-reported cardiovascular comorbidities, independent of disability status and other possible confounding variables, in persons with MS. PMID:21597305

  8. Security assessment of power systems including energy storage and with the integration of wind energy. Volume I. Digital transient simulation effort consulting Agreement No. 1. Final report

    SciTech Connect

    Anderson, P. M.

    1982-06-30

    The purpose of the effort reported has been to adapt the MOD-2 simulation models for implementation on a digital transient stability program. This has involved: selection of an appropriate host program, examination of the host program interface, analysis of the analog models for digital implementation, FORTRAN coding of the model equations, installation and debugging on the host program, and final model verification. Synchronous machine equations are analyzed, with particular emphasis on numerical solution. (LEW)

  9. ACTH-producing microadenoma of the pituitary in a young female infant with Cushing's disease: report of a case including immunocytologic and ultrastructural studies.

    PubMed

    Kim, M S; Wilson, G J; Holland, F J; Kovacs, K

    1986-01-01

    A female infant, younger than any other case in the literature, with ACTH-producing microadenoma of the pituitary is reported. She had full-blown symptoms and signs as well as laboratory evidence of Cushing's disease. The tumor was investigated by histology, immunocytology (avidin-biotin-peroxidase complex technique), and electron microscopy. The possibility that the tumor was derived from the fetal intermediate lobe is discussed.

  10. Stanford Synchrotron Radiation Laboratory. Activity report for 1988

    SciTech Connect

    Cantwell, K.

    1996-01-01

    For SSRL operations, 1988 was a year of stark contrasts. The first extended PEP parasitic running since the construction of our two beam lines on that storage ring took place in November and December. Four experiments discussed below, were performed and detailed operational procedures which allowed synchrotron radiation an high energy users to coexist were established. SSRL anticipates that there will be significant amounts of beam time when PEP is run again for high energy physics. On the other hand, activity on SPEAR consisted of brief parasitic running on the VUV lines in December when the ring was operated at 1.85 GeV for colliding beam experiments. There was no dedicated SPEAR running throughout the entire calendar year. This is the first time since dedicated SPEAR operation was initiated in 1980 that there was no such running. The decision was motivated by both cost and performance factors, as discussed in Section 1 of this report. Fortunately, SLAC and SSRL have reached an agreement on SPEAR and PEP dedicated time charges which eliminates the cost volatility which was so important in the cancellation of the June-July dedicated SPEAR run. As discussed in Section 2, the 3 GeV SPEAR injector construction is proceeding on budget and on schedule. The injector will overcome the difficulties associated with the SLC-era constraint of only two injections per day. SSR and SLAC have also embarked on a program to upgrade SPEAR to achieve high reliability and performance. As a consequence, SSRL`s users may anticipate a highly effective SPEAR by 1991, at the latest. At that time, SPEAR is expected to be fully dedicated to synchrotron radiation research and operated by SSRL. Also contained in this report is a discussion of the improvements to SSRL`s experimental facilities and highlights of the experiments of the past year.

  11. The β-actin gene promoter of rohu carp (Labeo rohita) drives reporter gene expressions in transgenic rohu and various cell lines, including spermatogonial stem cells.

    PubMed

    Barman, Hirak Kumar; Mohanta, Ramya; Patra, Swagat Kumar; Chakrapani, Vemulawada; Panda, Rudra Prasanna; Nayak, Swapnarani; Jena, Sasmita; Jayasankar, Pallipuram; Nandanpawar, Priyanka

    2015-06-01

    We previously characterized the β-actin gene promoter of Indian domesticated rohu carp (Labeo rohita) and made a reporter construct via fusion to green fluorescence protein (GFP) cDNA. In this study, the same construct was used to breed transgenic rohu fish. About 20% of the transgenic offspring showed ubiquitous expression of the reporter GFP gene. In a few of the transgenic fish, we documented massive epithelial and/or muscular expression with visible green color under normal light. The expression of GFP mRNA was higher in the muscle tissue of transgenic fish than in that of non-transgenic fish. A highly efficient nucleofection protocol was optimized to transfect proliferating spermatogonial cells of rohu using this reporter construct. The β-actin promoter also drove expressions in HEK293 (derived from human embryonic kidney cells), K562 (human leukemic cells) and SF21 (insect ovarian cells) lines. These findings imply conserved regulatory mechanisms of β-actin gene expression across eukaryotes. Furthermore, the isolated β-actin promoter with consensus regulatory elements has the potential to be used in generating transgenic carp with genes of interest and in basic biology research.

  12. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.

    PubMed

    Gomez, E; Pillon, A; Fenet, H; Rosain, D; Duchesne, M J; Nicolas, J C; Balaguer, P; Casellas, C

    2005-02-27

    In this work, the estrogenic effects of three classes of substances included in cosmetic formulations-parabens, ultraviolet (UV) screens, and musk fragrances-were studied. Their estrogenic activity was measured with the use of three reporter cell lines: HELN, HELN ERalpha, and HELN ERbeta. These three cell lines allowed for the measurement of estrogenic activity toward estrogen receptors alpha and beta (ERalpha and ERbeta, while taking nonspecific interactions into account. Eight of the 15 substances tested showed specific estrogenic activity with the following degree of potency on ERalpha butylparaben > propylparaben > homosalate = octyl-dimethyl-PABA = 4-methyl-benzylidenecamphor = octyl-methoxycinnamate > ethylparaben = galaxolide. Among these active substances, parabens activated ERalpha and ERbeta similarly, UV screens activated ERalpha moderately and had almost no effect on ERbeta, and fragrances did not activate ERbeta. Methylparaben, ethylparaben, musk moskene, celestolide, and cashmeran did not activate estrogenic responses up to 10(-5) M. Musk ketone and benzophenone-3 were not considered estrogenic at 10(-5) M.

  13. General aviation activity and avionics survey. Annual summary report, CY 1985

    SciTech Connect

    Not Available

    1987-03-01

    This report presents the results and a description of the 1985 General Aviation Activity and Avionics Survey. The survey was conducted during 1986 by the FAA to obtain information on the activity and avionics of the United States registered general aviation aircraft fleet, the dominant component of civil aviation in the U.S. The survey was based on a statistically selected sample of about 10.3 percent of the general aviation fleet. A responses rate of 63.7 percent was obtained. Survey results based upon response but are expanded upward to represent the total population. Survey results revealed that during 1985 an estimated 34.1 million hours of flying time were logged and 88.7 million operations were performed by the 210,654 active general aviation aircraft in the U.S. fleet. The mean annual flight time per aircraft was 158.2 hours. The active aircraft represented about 77.9 percent of the registered general aviation fleet. The report contains breakdowns of these and other statistics by manufacturer/model group, aircraft, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, avionics, engine hours, and miles flown estimates, as well as tables for detailed analysis of the avionics capabilities of the general aviation fleet. New to the report this year are estimates of the number of landings, IFR hours flown, and the cost and grade of fuel consumed by the GA fleet.

  14. Small Business Management Volume IV: Final Report. An Adult Education Program. Development, Demonstration and Evaluation of Management Education Programs for Small Business Entrepreneurs, Including Minorities.

    ERIC Educational Resources Information Center

    Persons, Edgar A.; Swanson, Gordon I.

    The purpose of the small business management program is to help families improve the effectiveness of their business operation and enable them to reach family and business goals. Similar to a successful program in farm management education operational in Minnesota since 1952, the program includes classroom instruction, small group instruction,…

  15. Should Non-Cognitive Skills Be Included in School Accountability Systems? Preliminary Evidence from California's CORE Districts. Evidence Speaks Reports, Vol 1, #13

    ERIC Educational Resources Information Center

    West, Martin R.

    2016-01-01

    Evidence confirms that student skills other than academic achievement and ability predict a broad range of academic and life outcomes. This evidence, along with a new federal requirement that state accountability systems include an indicator of school quality or student success not based on test scores, has sparked interest in incorporating such…

  16. Including Exceptions: A System for Educating Students with Dual Sensory Impairments and Other Extreme Disabilities in General Education Settings. A Final Report.

    ERIC Educational Resources Information Center

    Ferguson, Dianne; And Others

    The Including Exceptions in Schools (IES) Project attempted to develop, implement, and validate a system for educating students with the most extreme dual sensory and other cognitive, physical, and health impairments in general education settings. The project involved 17 elementary and secondary students in Oregon, Idaho, and Louisiana over a…

  17. PR[superscript 2]EPS: Preparation, Recruitment, Retention and Excellence in the Physical Sciences, Including Engineering. A Report on the 2004, 2005 and 2006 Science Summer Camps

    ERIC Educational Resources Information Center

    Bachman, Nancy J.; Bischoff, Paul J.; Gallagher, Hugh; Labroo, Sunil; Schaumloffel, John C.

    2008-01-01

    Now in its fourth year, PR[superscript 2]EPS is a National Science Foundation funded initiative designed to recruit high school students to attend college majoring in the physical sciences, including engineering and secondary science education, and to help ensure their retention within the program until graduation. A central feature of the…

  18. A multidisciplinary approach including the use of platelet-rich plasma to treat an elite athlete with patellar tendinopathy – a case report

    PubMed Central

    Rowan, Tracy L.; Drouin, Jillian L.

    2013-01-01

    Objective: Patellar tendinopathy affects a substantial proportion of athletes involved in jumping or kicking activities. Platelet rich plasma (PRP) injections may be a promising treatment used in conjunction with common traditional therapies. Clinical Features: Patellar tendinopathy is often the result of repetitive or excessive overload on the patellar tendon. Activity modification, cryotherapy, eccentric exercises, shockwave therapy, and PRP have been indicated as treatment options during various stages of this condition. Intervention and Outcome: A 23 year old female, elite track and field athlete was managed for patellar tendinopathy with a combination of traditional therapeutic interventions as well as a PRP injection. This athlete returned to pre-injury level of competition six months post-injection. Conclusion: Emerging literature on PRP appears to be promising for patellar tendinopathy, however, it remains unclear which patients may benefit most and whether the stage of the disorder has an impact on the clinical outcome. PMID:24302777

  19. Report of the Integrated Program Planning Activity for the DOE Fusion Energy Sciences Program

    SciTech Connect

    2000-12-01

    This report of the Integrated Program Planning Activity (IPPA) has been prepared in response to a recommendation by the Secretary of Energy Advisory Board that, ''Given the complex nature of the fusion effort, an integrated program planning process is an absolute necessity.'' We, therefore, undertook this activity in order to integrate the various elements of the program, to improve communication and performance accountability across the program, and to show the inter-connectedness and inter-dependency of the diverse parts of the national fusion energy sciences program. This report is based on the September 1999 Fusion Energy Sciences Advisory Committee's (FESAC) report ''Priorities and Balance within the Fusion Energy Sciences Program''. In its December 5,2000, letter to the Director of the Office of Science, the FESAC has reaffirmed the validity of the September 1999 report and stated that the IPPA presents a framework and process to guide the achievement of the 5-year goals listed in the 1999 report. The National Research Council's (NRC) Fusion Assessment Committee draft final report ''An Assessment of the Department of Energy's Office of Fusion Energy Sciences Program'', reviewing the quality of the science in the program, was made available after the IPPA report had been completed. The IPPA report is, nevertheless, consistent with the recommendations in the NRC report. In addition to program goals and the related 5-year, 10-year, and 15-year objectives, this report elaborates on the scientific issues associated with each of these objectives. The report also makes clear the relationships among the various program elements, and cites these relationships as the reason why integrated program planning is essential. In particular, while focusing on the science conducted by the program, the report addresses the important balances between the science and energy goals of the program, between the MFE and IFE approaches, and between the domestic and international aspects

  20. Two dimensional and zero field NMR studies of coal structure: Final progress report, including the period July 1, 1987 to September 30, 1987

    SciTech Connect

    Zilm, K.W.

    1987-12-01

    This report covers the progress made on the title project during the last quarter and summarizes the accomplishments for the project period. During the last three months we have completed a full analysis of the limitations of our ADIPSHIFT 2D NMR experiment that we have developed to determine the distribution of functional types of carbon in coals. This is an extensive piece of work and will provide a firm foundation for the application of the method to complex organic solids in the future. A particularly useful graphical analysis is described for use with unknowns such as coals. 17 refs.