Science.gov

Sample records for activities reported include

  1. Activity report

    SciTech Connect

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  2. Annual report of the National Advisory Committee for Aeronautics (42nd). administrative report including Technical Report nos. 1254 to 1295

    NASA Technical Reports Server (NTRS)

    1957-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  3. Annual report of the National Advisory Committee for Aeronautics (35th). administrative report including Technical Report nos. 922 to 950

    NASA Technical Reports Server (NTRS)

    1951-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  4. Annual report of the National Advisory Committee for Aeronautics (29th) : administrative report including Technical Report nos. 752 to 773

    NASA Technical Reports Server (NTRS)

    1948-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  5. Annual report of the National Advisory Committee for Aeronautics (34th). administrative report including Technical Report nos. 892 to 921

    NASA Technical Reports Server (NTRS)

    1951-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  6. Annual report of the National Advisory Committee for Aeronautics (41st). administrative report including Technical Report nos. 1210 to 1253

    NASA Technical Reports Server (NTRS)

    1957-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  7. Annual report of the National Advisory Committee for Aeronautics (40th). administrative report including Technical Report nos. 1158-1209

    NASA Technical Reports Server (NTRS)

    1956-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  8. Annual report of the National Advisory Committee for Aeronautics (38th). administrative report including Technical Report nos. 1059 to 1110

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  9. Annual report of the National Advisory Committee for Aeronautics (36th). administrative report including Technical Report nos. 951 to 1002

    NASA Technical Reports Server (NTRS)

    1951-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  10. Annual Report of the National Advisory Committee for Aeronautics (1st). [Administrative Report Including Technical Reports Nos. 1 to 7

    NASA Technical Reports Server (NTRS)

    1916-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations, and a compilation of technical reports produced.

  11. LANSCE Activity Report

    SciTech Connect

    Amy Robinson; Audrey Archuleta; Barbara Maes; Dan Strottman; Earl Hoffman; Garth Tietjen; Gene Farnum; Geoff Greene; Joyce Roberts; Ken Johnson; Paul Lewis; Roger Pynn; Stan Schriber; Steve Sterbenz; Steve Wender; Sue Harper

    1999-02-01

    The Los Alamos Neutron Science Center Activity Report describes scientific and technological progress and achievements in LANSCE Division during the period of 1995 to 1998. This report includes a message from the Division Director, an overview of LANSCE, sponsor overviews, research highlights, advanced projects and facility upgrades achievements, experimental and user program accomplishments, news and events, and a list of publications. The research highlights cover the areas of condensed-matter science and engineering, accelerator science, nuclear science, and radiography. This report also contains a compact disk that includes an overview, the Activity Report itself, LANSCE operations progress reports for 1996 and 1997, experiment reports from LANSCE users, as well as a search capability.

  12. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  13. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  14. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  15. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  16. 20 CFR 408.710 - What must your report include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What must your report include? 408.710 Section 408.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Reporting Requirements § 408.710 What must your report include? When you make a...

  17. Annual report for the National Advisory Committee for Aeronautics (10th).administrative report including Technical Reports nos. 186 to 209

    NASA Technical Reports Server (NTRS)

    1925-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  18. Annual report of the National Advisory Committee for Aeronautics (20th).administrative report including Technical Report nos. 475 to 507

    NASA Technical Reports Server (NTRS)

    1935-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  19. Annual report for the National Advisory Committee for Aeronautics (11th).administrative report including Technical Reports nos. 210 to 232

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  20. Annual report of the National Advisory Committee for Aeronautics (21st).administrative report including Technical Report nos. 508 to 541

    NASA Technical Reports Server (NTRS)

    1936-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  1. Annual report of the National Advisory Committee for Aeronautics (14th).administrative report including Technical Reports nos. 283 to 308

    NASA Technical Reports Server (NTRS)

    1929-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  2. Annual report of the National Advisory Committee for Aeronautics (18th).administrative report including Technical Report nos. 401 to 440

    NASA Technical Reports Server (NTRS)

    1933-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  3. Annual report of the National Advisory Committee for Aeronautics (13th).administrative report including Technical Reports nos. 257 to 282

    NASA Technical Reports Server (NTRS)

    1928-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  4. Annual report of the National Advisory Committee for Aeronautics (16th).administrative report including Technical Reports nos. 337 to 364

    NASA Technical Reports Server (NTRS)

    1931-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  5. Annual report for the National Advisory Committee for Aeronautics (12th).administrative report including Technical Reports nos. 233 to 256

    NASA Technical Reports Server (NTRS)

    1927-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  6. Annual report of the National Advisory Committee for Aeronautics (22nd).administrative report including Technical Report nos. 542 to 576

    NASA Technical Reports Server (NTRS)

    1937-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  7. Annual report of the National Advisory Committee for Aeronautics (19th).administrative report including Technical Report nos. 441 to 474

    NASA Technical Reports Server (NTRS)

    1934-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  8. Annual report of the National Advisory Committee for Aeronautics (17th).administrative report including Technical Report nos. 365 to 400

    NASA Technical Reports Server (NTRS)

    1932-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the president, congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  9. Annual report of the National Advisory Committee for Aeronautics (15th).administrative report including Technical Reports nos. 309 to 336

    NASA Technical Reports Server (NTRS)

    1930-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  10. Annual report of the National Advisory Committee for Aeronautics (32nd).administative report including Technical Report nos. 834 to 862

    NASA Technical Reports Server (NTRS)

    1949-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  11. Annual report of the National Advisory Committee for Aeronautics (3rd).administrative report including Technical Report nos. 13 to 23

    NASA Technical Reports Server (NTRS)

    1918-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, and problems.

  12. Annual report of the National Advisory Committee for Aeronautics (33rd).administrative report including Technical Report nos. 863 to 891

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  13. Annual report of the National Advisory Committee for Aeronautics (30th).administrative report including Technical Report nos. 774 to 803

    NASA Technical Reports Server (NTRS)

    1949-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of Committee's activities and research accomplished, bibliographies, and financial report.

  14. Annual report of the National Advisory Committee for Aeronautics (23rd).administrative report including Technical Report nos. 577 to 611

    NASA Technical Reports Server (NTRS)

    1937-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  15. Annual report of the National Advisory Committee for Aeronautics (25th).administrative report including Technical Report nos. 645 to 680

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  16. Annual Report of the National Advisory Committee for Aeronautics (27Th).Administrative Report Including Technical Report Nos. 704 to 726

    NASA Technical Reports Server (NTRS)

    1942-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  17. Annual report of the National Advisory Committee for Aeronautics (26th).administrative report including Technical Report nos. 681 to 703

    NASA Technical Reports Server (NTRS)

    1941-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  18. Annual report of the National Advisory Committee for Aeronautics (8th).administrative report including Technical Reports nos. 133 to 158

    NASA Technical Reports Server (NTRS)

    1923-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, congressional report, summaries of the committee's activities and research accomplished, and expenditures.

  19. Annual report of the National Advisory Committee for Aeronautics (28th).administrative report including Technical Report nos. 727 to 751

    NASA Technical Reports Server (NTRS)

    1946-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  20. Annual Report of the National Advisory Committee for Aeronautics (9Th).Administrative Report Including Technical Reports Nos. 159 to 185

    NASA Technical Reports Server (NTRS)

    1924-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, and expenditures.

  1. Annual report of the National Advisory Committee for Aeronautics (24th).administrative report including Technical Report nos. 612 to 644

    NASA Technical Reports Server (NTRS)

    1939-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, summaries of the committee's activities and research accomplished, bibliographies, and financial report.

  2. Annual report of the National Advisory Committee for Aeronautics (7th).administrative report including Technical Reports nos. 111 to 132

    NASA Technical Reports Server (NTRS)

    1923-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, and expenditures.

  3. Everglades National Park Including Biscayne National Park. Activity Book.

    ERIC Educational Resources Information Center

    Ruehrwein, Dick

    Intended to help elementary school children learn about the resources of the Everglades and Biscayne National Parks, this activity book includes information, puzzles, games, and quizzes. The booklet deals with concepts related to: (1) the seasons; (2) fire ecology; (3) water; (4) fish; (5) mammals; (6) mosquitos; (7) birds; (8) venomous snakes;…

  4. Annual report of the National Advisory Committee for Aeronautics (5th).administrative report including Technical Reports nos. 51 to 82

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, and a compilation of technical reports produced.

  5. Annual report of the National Advisory Committee for Aeronautics (4th).administrative report including Technical Reports nos. 24 to 50

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations, and a compilation of technical reports produced.

  6. Chemical Compatibility Testing Final Report Including Test Plans and Procedures

    SciTech Connect

    NIMITZ,JONATHAN S.; ALLRED,RONALD E.; GORDON,BRENT W.; NIGREY,PAUL J.; MCCONNELL,PAUL E.

    2001-07-01

    This report provides an independent assessment of information on mixed waste streams, chemical compatibility information on polymers, and standard test methods for polymer properties. It includes a technology review of mixed low-level waste (LLW) streams and material compatibilities, validation for the plan to test the compatibility of simulated mixed wastes with potential seal and liner materials, and the test plan itself. Potential packaging materials were reviewed and evaluated for compatibility with expected hazardous wastes. The chemical and physical property measurements required for testing container materials were determined. Test methodologies for evaluating compatibility were collected and reviewed for applicability. A test plan to meet US Department of Energy and Environmental Protection Agency requirements was developed. The expected wastes were compared with the chemical resistances of polymers, the top-ranking polymers were selected for testing, and the most applicable test methods for candidate seal and liner materials were determined. Five recommended solutions to simulate mixed LLW streams are described. The test plan includes descriptions of test materials, test procedures, data collection protocols, safety and environmental considerations, and quality assurance procedures. The recommended order of testing to be conducted is specified.

  7. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... substance activity, as defined by regulations issued by the U.S. Environmental Protection Agency (EPA) at 40 CFR part 373, took place on the property. Hazardous substance activity includes situations where any... property. Agencies reporting such property must review the regulations issued by EPA at 40 CFR part 373...

  8. Including indigenous knowledge and experience in IPCC assessment reports

    NASA Astrophysics Data System (ADS)

    Ford, James D.; Cameron, Laura; Rubis, Jennifer; Maillet, Michelle; Nakashima, Douglas; Willox, Ashlee Cunsolo; Pearce, Tristan

    2016-04-01

    The IPCC is the leading international body for the assessment of climate change, forming the interface between science, policy and global politics. Indigenous issues have been under-represented in previous IPCC assessments. In this Perspective, we analyse how indigenous content is covered and framed in the Working Group II (WGII) portion of the Fifth Assessment Report (AR5). We find that although there is reference to indigenous content in WGII, which increased from the Fourth Assessment Report, the coverage is general in scope and limited in length, there is little critical engagement with indigenous knowledge systems, and the historical and contextual complexities of indigenous experiences are largely overlooked. The development of culturally relevant and appropriate adaptation policies requires more robust, nuanced and appropriate inclusion and framing of indigenous issues in future assessment reports, and we outline how this can be achieved.

  9. Annual report of the National Advisory Committee for Aeronautics (6th).administrative report including Technical Reports nos. 83 to 110

    NASA Technical Reports Server (NTRS)

    1921-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, House of Representatives bill 14061, a copy of the bill introduced to the House of Representatives to regulate air navigation, and a compilation of technical reports produced.

  10. Antiradical activity of gallic acid included in lipid interphases.

    PubMed

    Salcedo, C L; Frías, M A; Cutro, A C; Nazareno, M A; Disalvo, E A

    2014-10-01

    Polyphenols are well known as antioxidant agents and by their effects on the hydration layers of lipid interphases. Among them, gallic acid and its derivatives are able to decrease the dipole potential and to act in water as a strong antioxidant. In this work we have studied both effects on lipid interphases in monolayers and bilayers of dimyristoylphosphatidylcholine. The results show that gallic acid (GA) increases the negative surface charges of large unilamellar vesicles (LUVs) and decreases the dipole potential of the lipid interphase. As a result, positively charged radical species such as ABTS(+) are able to penetrate the membrane forming an association with GA. These results allow discussing the antiradical activity (ARA) of GA at the membrane phase which may be taking place in water spaces between the lipids.

  11. Annual report of the National Advisory Committee for Aeronautics (2nd) together with the message of the President of the United States transmitting the report for the fiscal year ending June 30, 1916. administrative report including technical report

    NASA Technical Reports Server (NTRS)

    1917-01-01

    Report includes the National Advisory Committee for Aeronautics letter of submittal to the President, Congressional report, summaries of the committee's activities and research accomplished, expenditures, problems, recommendations and a compilation of technical reports produced.

  12. Activities report to NATO

    NASA Astrophysics Data System (ADS)

    1992-09-01

    Academic, research and financial developments at the von Karman Institute for Fluid Dynamics during the period from 1 Oct. 1991 - 30 Sep. 1992 are reported. The Institute is incorporated as an international scientific association with the following aims: to promote the training of scientists and engineers from NATO (North Atlantic Treaty Organization) countries in the field of fluid dynamics; to contribute to the dissemination of knowledge in the field of fluid dynamics; to undertake, to investigate, and to promote studies and research in the field of theoretical and experimental fluid dynamics, including numerical methods. Education and research are conducted within three broad areas of fluid dynamics, each of which is reflected in the name of a department: aeronautics/aerospace; environmental and applied fluid dynamics; and turbomachinery.

  13. NSLS 2009 Activity Report

    SciTech Connect

    Nasta K.; Mona R.

    2009-05-01

    2009 was an incredibly exciting year for light sources at Brookhaven. The National Synchrotron Light Source (NSLS) hosted more than 2,200 visiting researchers, who, along with the about 50 members of our scientific staff, produced a total of 957 publications - about 20 percent of which appeared in premier journals. Covering topics ranging from Alzheimer's disease detection to ethanol-powered fuel cells, a sampling of these findings can be found in this Activity Report. We've also seen the resurfacing of some of our long-time users hard work. I was very proud to hear that two of the three recipients of the 2009 Nobel Prize in Chemistry have ties to the NSLS. Venki Ramakrishnan, a former employee in Brookhaven's biology department and long-time user of the NSLS, now at Cambridge University, and Thomas A. Steitz of Yale University, also a long-time NSLS user, shared the prize with Ada E. Yonath of the Weizmann Institute of Science for their work on the structure and function of the ribosome. In the late 1990s, Ramakrishnan and Steitz used protein crystallography at the NSLS to gather atomic-level images of two ribosome subunits: 30S (Ramakrishnan) and 50S (Steitz). Both laureates solved the high-resolution structures for these subunits based on this data. After struggling with a rough budget for several years, we received excellent funding, and then some, this year. In addition to NSLS operations funding, we received $3 million in funds from the American Recovery and Reinvestment Act (ARRA). We used that additional money for two exciting projects: construction of a full-field x-ray microscope and acquisition of several advanced x-ray detectors. The x-ray microscope will be able to image objects with a targeted spatial resolution of 30 nanometers. This capability will be particularly important for new initiatives in energy research and will prepare our users for the projected 1-nanometer resolution benchmark at the National Synchrotron Light Source II (NSLS-II). The

  14. Optimal design of active and semi-active suspensions including time delays and preview

    NASA Astrophysics Data System (ADS)

    Hac', A.; Youn, I.

    1993-10-01

    Several control laws for active and semi-active suspension based on a linear half car model are derived and investigated. The strategies proposed take full advantage of the fact that the road input to the rear wheels is a delayed version of that to the front wheels, which in turn can be obtained either from the measurements of the front wheels and body motions or by direct preview of road irregularities if preview sensors are available. The suspension systems are optimized with respect to ride comfort, road holding and suspension rattle space as expressed by the mean-square-values of body acceleration (including effects of heave and pitch), tire deflections and front and rear suspension travels. The optimal control laws that minimize the given performance index and include passivity constraints in the semi-active case are derived using calculus of variation. The optimal semi-active suspension becomes piecewise linear, varying between passive and fully active systems and combinations of them. The performances of active and semi-active systems with and without preview were evaluated by numerical simulation in the time and frequency domains. The results show that incorporation of time delay between the front and rear axles in controller design improves the dynamic behavior of the rear axle and control of body pitch motion, while additional preview improves front wheel dynamics and body heave.

  15. Needs assessment activity report

    SciTech Connect

    Not Available

    1994-08-01

    As part of a Transportation Management Division task (TMD), the Packaging Programs and Testing Group within Westinghouse Hanford Company (WHC) has assessed the packaging needs of some of the mid- and small-sized US Department of Energy (DOE) sites by visiting them and meeting with their transportation and packaging personnel. To date, ten DOE facilities have been visited. As a result, these sites have been informed of some of the packaging activities that TMD has sponsored and is sponsoring, have been apprised of possible upcoming changes to transportation regulations, have discussed their short-term packaging needs, and have shared unique packaging they have developed which may be of use to other DOE facilities.. This report summarizes the findings from visits to the following sites: Fermi National Laboratory; Argonne National Laboratory; New Brunswick Laboratory; EG and G Mound Applied Technologies; Fernald Environmental Management Project; West Valley Demonstration Project; Lawrence Berkeley Laboratory; Stanford Linear Accelerator Center; Brookhaven National Laboratory; and Princeton Plasma Physics Laboratory.

  16. Technical planning activity: Final report

    SciTech Connect

    Not Available

    1987-01-01

    In April 1985, the US Department of Energy's (DOE's) Office of Fusion Energy commissioned the Technical Planning Activity (TPA). The purpose of this activity was to develop a technical planning methodology and prepare technical plans in support of the strategic and policy framework of the Magnetic Fusion Program Plan issued by DOE in February 1985. Although this report represents the views of only the US magnetic fusion community, it is international in scope in the sense that the technical plans contained herein describe the full scope of the tasks that are prerequisites for the commercialization of fusion energy. The TPA has developed a well-structured methodology that includes detailed definitions of technical issues, definitions of program areas and elements, statements of research and development objectives, identification of key decision points and milestones, and descriptions of facility requirements.

  17. ALS Activity Report 2004

    SciTech Connect

    Tamura , Lori S.

    2005-07-11

    This annual report of the Advanced Light Source details science highlights and facility developments during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  18. E-Division activities report

    SciTech Connect

    Barschall, H.H.

    1984-07-01

    E (Experimental Physics) Division carries out basic and applied research in atomic and nuclear physics, in materials science, and in other areas related to the missions of the Laboratory. Some of the activities are cooperative efforts with other divisions of the Laboratory, and, in a few cases, with other laboratories. Many of the experiments are directly applicable to problems in weapons and energy, some have only potential applied uses, and others are in pure physics. This report presents abstracts of papers published by E (Experimental Physics) Division staff members between July 1983 and June 1984. In addition, it lists the members of the scientific staff of the division, including visitors and students, and some of the assignments of staff members on scientific committees. A brief summary of the budget is included.

  19. Advanced Light Source Activity Report 2000

    SciTech Connect

    Greiner, A.; Moxon, L.; Robinson, A.; Tamura, L.

    2001-04-01

    This is an annual report, detailing activities at the Advanced Light Source for the year 2000. It includes highlights of scientific research by users of the facility as well as information about the development of the facility itself.

  20. ESU Activity Report 2011

    ERIC Educational Resources Information Center

    Pall, Allan, Ed.; Ufert, Karina, Ed.; Slegers, Marianne, Ed.

    2011-01-01

    European Students' Union (ESU) has been representing students since 1982. In these, almost 30 years, ESU has been going from strength to strength as a European organisation. Each year has been crucial. This report brings to the fore its notable achievements and work done in 2011. The carousel of higher education reform on the national level was at…

  1. ESU Activity Report 2009

    ERIC Educational Resources Information Center

    European Students' Union (NJ1), 2009

    2009-01-01

    This report tells a short story of European Students' Union (ESU's) work in 2009. It highlights some of the key areas that ESU worked on, while giving some examples of each general area as outlined in the Plan of Work adopted by the ESU members--National Unions of Students--in November 2008. Members have linked to relevant web documents and…

  2. Dissemination Activities Report

    ERIC Educational Resources Information Center

    Barclay, Hanna; Batatia, Hudj; Bauters, Merja; Ben Ami, Zvi; Drachman, Raul; Flouris, Giorgos; Jadin, Tanja; Jalonen, Satu; Karlgren, Klas; Karpati, Andrea; Kotzinos, Dimitris; Lakkala, Minna; Lallimo, Jiri; Moen, Anne; Nygard, Kathrine; Paavola, Sami; Padiglia, Sheila; Scapolla, Marina; Sins, Patrick; Vasileva, Tania

    2008-01-01

    In the first 24 months of the project, KP-Lab members were highly dedicated to dissemination and were engaged in various dissemination activities that contributed to the prime objective of the KP-Lab dissemination efforts which is "to make the project widely known to a variety of prospective users and, at a later stage, to promote the…

  3. 30 CFR 285.701 - What must I include in my Facility Design Report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my Facility Design Report? 285.701 Section 285.701 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... Design, Fabrication, and Installation Reports § 285.701 What must I include in my Facility Design...

  4. 40 CFR 60.2220 - What must I include in the deviation report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Commercial and Industrial Solid Waste Incineration Units for Which Construction Is Commenced After November 30, 1999 or for Which Modification or Reconstruction Is Commenced on or After June 1, 2001 Recordkeeping and Reporting § 60.2220 What must I include in the deviation report? In each report required...

  5. Report on geologic exploration activities

    SciTech Connect

    1980-01-01

    This report provides an overview of the geological exploration activities being carried out as part of the National Waste Terminal Storage (NWTS) Program, which has been established by the US Department of Energy (DOE) to develop the technology and provide the facilities for the safe, environmentally acceptable isolation of civilian high-level and transuranic nuclear wastes, including spent fuel elements, for which the Federal government is reponsible. The principal programmatic emphasis is on disposal in mined geologic repositories. Explorations are being conducted or planned in various parts of the country to identify potential sites for such repositories. The work is being undertaken by three separate but coordinated NWTS project elements. Under the Basalt Waste Isolation Project (BWIP), basalt formations underlying DOE's Hanford Reservation are being investigated. Granite, tuff, and shale formations at the DOE Nevada Test Site (NTS) are being similarly studied in the Nevada Nuclear Waste Storage Investigations (NNWSI). The Office of Nuclear Waste Isolation (ONWI) is investigating domed salt formations in several Gulf Coast states and bedded salt formations in Utah and Texas. Th ONWI siting studies are being expanded to include areas overlying crystalline rocks, shales, and other geohydrologic systems. The current status of these NWTS efforts, including the projected budgets for FY 1981, is summarized, and the criteria and methodology being employed in the explorations are described. The consistency of the overall effort with the recommendations presented in the Report to the President by the Interagency Review Group on Nuclear Waste Management (IRG), as well as with documents representing the national technical consensus, is discussed.

  6. Status report of RMS active damping augmentation

    NASA Technical Reports Server (NTRS)

    Gilbert, Mike; Demeo, Martha E.

    1993-01-01

    A status report of Remote Manipulator System (RMS) active damping augmentation is presented. Topics covered include: active damping augmentation; benefits of RMS ADA; simulated payload definition; sensor and actuator definition; ADA control law design; Shuttle Engineering Simulator (SES) real-time simulation; and astronaut evaluation.

  7. E-Division activities report

    SciTech Connect

    Barschall, H.H.

    1981-07-01

    This report describes some of the activities in E (Experimental Physics) Division during the past year. E-Division carries out research and development in areas related to the missions of the Laboratory. Many of the activities are in pure and applied atomic and nuclear physics and in material science. In addition this report describes work on accelerators, microwaves, plasma diagnostics, determination of atmospheric oxygen and of nitrogen in tissue.

  8. E-Division activities report

    SciTech Connect

    Barschall, H.H.

    1983-07-01

    This report describes some of the activities in E (Experimental Physics) Division during the past year. E-division carries out research and development in areas related to the missions of the Laboratory. Many of the activities are in pure and applied atomic and nuclear physics and in materials science. In addition, this report describes development work on accelerators and on instrumentation for plasma diagnostics, nitrogen exchange rates in tissue, and breakdown in gases by microwave pulses.

  9. Nuclear waste isolation activities report

    SciTech Connect

    1980-12-01

    Included are: a report from the Deputy Assistant Secretary, a summary of recent events, new literature, a list of upcoming waste management meetings, and background information on DOE`s radwaste management programs. (DLC)

  10. 75 FR 20387 - Contech Castings, LLC, Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Contech Castings, LLC, Including Workers Whose Unemployment Insurance... subject firm had their wages reported under a separate unemployment insurance (UI) tax account under...

  11. 77 FR 13131 - Proposed Collection: Comment Request Post-Award Reporting Requirements Including New Research...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... required to report annually. Affected Public: Universities and other research institutions; Business or... Requirements Including New Research Performance Progress Report Collection SUMMARY: In compliance with the... (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of...

  12. 77 FR 38843 - Submission for OMB Review; Comment Request: Post-Award Reporting Requirements Including New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Public: Universities and other research ] institutions; Business or other for-profit; Not-for-profit... Reporting Requirements Including New Research Performance Progress Report Collection; Revision Summary... Institutes of Health (NIH) has submitted to the Office of Management and Budget (OMB) a request for...

  13. 30 CFR 250.1933 - What procedures must be included for reporting unsafe working conditions?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SHELF Safety and Environmental Management Systems (SEMS) § 250.1933 What procedures must be included for... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What procedures must be included for reporting unsafe working conditions? 250.1933 Section 250.1933 Mineral Resources BUREAU OF SAFETY AND...

  14. 30 CFR 250.1933 - What procedures must be included for reporting unsafe working conditions?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SHELF Safety and Environmental Management Systems (SEMS) § 250.1933 What procedures must be included for... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What procedures must be included for reporting unsafe working conditions? 250.1933 Section 250.1933 Mineral Resources BUREAU OF SAFETY AND...

  15. 76 FR 30396 - Tektronix, Inc., Including Workers Whose UI Wages Were Reported Under Tektronix Component...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Tektronix, Inc. and Including On-Site Leased Workers From Adecco Employment Services Beaverton, OR; Amended... Services, Beaverton, Oregon, who became totally or partially separated from employment on or after November... Employment and Training Administration Tektronix, Inc., Including Workers Whose UI Wages Were Reported...

  16. System-Cost-Optimized Smart EVSE for Residential Application: Final Technical Report including Manufacturing Plan

    SciTech Connect

    Zhu, Charles

    2015-05-15

    In the 2nd quarter of 2012, a program was formally initiated at Delta Products to develop smart-grid-enabled Electric Vehicle Supply Equipment (EVSE) product for residential use. The project was funded in part by the U.S. Department of Energy (DOE), under award DE-OE0000590. Delta products was the prime contractor to DOE during the three year duration of the project. In addition to Delta Products, several additional supplier-partners were engaged in this research and development (R&D) program, including Detroit Edison DTE, Mercedes Benz Research and Development North America, and kVA. This report summarizes the program and describes the key research outcomes of the program. A technical history of the project activities is provided, which describes the key steps taken in the research and the findings made at successive stages in the multi-stage work. The evolution of an EVSE prototype system is described in detail, culminating in prototypes shipped to Department of Energy Laboratories for final qualification. After the program history is reviewed, the key attributes of the resulting EVSE are described in terms of functionality, performance, and cost. The results clearly demonstrate the ability of this EVSE to meet or exceed DOE's targets for this program, including: construction of a working product-intent prototype of a smart-grid-enabled EVSE, with suitable connectivity to grid management and home-energy management systems, revenue-grade metering, and related technical functions; and cost reduction of 50% or more compared to typical market priced EVSEs at the time of DOE's funding opportunity announcement (FOA), which was released in mid 2011. In addition to meeting all the program goals, the program was completed within the original budget and timeline established at the time of the award. The summary program budget and timeline, comparing plan versus actual values, is provided for reference, along with several supporting explanatory notes. Technical information

  17. 77 FR 62265 - Long Elevator & Machine Company, Inc., Including Workers Whose Wages Were Reported Through Kone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ... Were Reported Through Kone, Inc., Riverton, IL; Notice of Negative Determination on Reconsideration On... June 6, 2012 (77 FR 33490). The workers' firm was engaged in activities related to the supply of... resulted in a negative determination based on no shift in production of elevator component parts to...

  18. Reporters to monitor cellular MMP12 activity

    NASA Astrophysics Data System (ADS)

    Cobos-Correa, Amanda; Mall, Marcus A.; Schultz, Carsten

    2010-02-01

    Macrophage elastase, also called MMP12, belongs to a family of proteolytic enzymes whose best known physiological function is the remodeling of the extracellular matrix. Under certain pathological conditions, including inflammation, chronic overexpression of MMP12 has been observed and its elevated proteolytic activity has been suggested to be the cause of pulmonary emphysema. However, it was until recently impossible to monitor the activity of MMP12 under disease conditions, mainly due to a lack of detection methods. Recent development of new reporters for monitoring MMP12 activity in living cells, such as LaRee1, provided novel insights into the pathobiology of MMP12 in pulmonary inflammation.1 In the future, these reporters might contribute to improved diagnosis and in finding better treatments for chronic inflammatory lung diseases and emphysema. Our approach for visualizing MMP12 activity is based on peptidic, membrane-targeted FRET (Foerster Resonance Energy Transfer) reporters. Here we describe a set of new reporters containing different fluorophore pairs as well as modifications in the membrane-targeting lipid moiety. We studied the influence of these modifications on reporter performance and the reporter mobility on live cell membranes by FRAP (fluorescence recovery after photobleaching). Finally, we generated several new fluorescently labeled MMP inhibitors based on the peptidic reporter structures as prototypes for future tools to inhibit and monitor MMP activity at the same time.

  19. 41 CFR 102-37.75 - What should be included in a shortage report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What should be included in a shortage report? 102-37.75 Section 102-37.75 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY...

  20. 25 CFR 183.16 - What information must be included in the Tribe's annual report?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What information must be included in the Tribe's annual report? 183.16 Section 183.16 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER USE AND DISTRIBUTION OF THE SAN CARLOS APACHE TRIBE DEVELOPMENT TRUST FUND AND SAN CARLOS APACHE...

  1. 30 CFR 285.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Facility Design, Fabrication, and Installation Reports § 285.702 What must I include in my Fabrication and... fabricated and installed in accordance with the design criteria identified in the Facility Design...

  2. 30 CFR 285.702 - What must I include in my Fabrication and Installation Report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What must I include in my Fabrication and Installation Report? 285.702 Section 285.702 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... approved CVA to be in accordance with accepted engineering practices and the approved SAP, GAP, or COP...

  3. 75 FR 34170 - Circuit Science, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... (75 FR 3929). At the request of the state, the Department reviewed the certification for workers of... Employment and Training Administration Circuit Science, Inc., Including Workers Whose Unemployment Insurance... subject firm had their wages reported under a separated unemployment insurance (UI) tax account under...

  4. 77 FR 44678 - Lawson Software, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Were Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... the Federal Register on July 18, 2012 (77 FR 42336). The Department reviewed the certification for... Employment and Training Administration Lawson Software, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Were Reported Through Lawson Software Americas, Inc. and Infor, Inc., St. Paul,...

  5. Feasibility of including fugitive PM-10 emissions estimates in the EPA emissions trends report

    SciTech Connect

    Barnard, W.; Carlson, P.

    1990-09-01

    The report describes the results of Part 2 of a two part study. Part 2 was to evaluate the feasibility of developing regional emission trends for PM-10. Part 1 was to evaluate the feasibility of developing VOC emission trends, on a regional and temporal basis. These studies are part of the effort underway to improve the national emission trends. Part 1 is presented in a separate report. The categories evaluated for the feasibility of developing regional emissions estimates were: unpaved roads, paved roads, wind erosion, agricultural tilling, construction activities, feedlots, burning, landfills, mining and quarrying unpaved parking lots, unpaved airstrips and storage piles.

  6. Improvements to the FATOLA computer program including added actively controlled landing gear subroutines

    NASA Technical Reports Server (NTRS)

    Mall, G. H.

    1983-01-01

    Modifications to a multi-degree-of-freedom flexible aircraft take-off and landing analysis (FATOLA) computer program, including a provision for actively controlled landing gears to expand the programs simulation capabilities, are presented. Supplemental instructions for preparation of data and for use of the modified program are included.

  7. 40 CFR 62.15340 - What must I include in the annual report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... emissions. (2) For Class I municipal waste combustion units only, nitrogen oxides emissions. (3) Carbon... combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four..., nitrogen oxides emissions. (3) Carbon monoxide emissions. (4) Load level of the municipal waste...

  8. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... parameters (use appropriate units as specified in table 2 of this subpart): (1) Dioxins/furans. (2) Cadmium... stack test for dioxins/furans emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon...

  9. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... parameters (use appropriate units as specified in table 2 of this subpart): (1) Dioxins/furans. (2) Cadmium... stack test for dioxins/furans emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon...

  10. 40 CFR 62.15340 - What must I include in the annual report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... § 62.15300(a): (1) Dioxins/furans. (2) Cadmium. (3) Lead. (4) Mercury. (5) Opacity. (6) Particulate... combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent dioxins/furans and...

  11. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... parameters (use appropriate units as specified in table 2 of this subpart): (1) Dioxins/furans. (2) Cadmium... stack test for dioxins/furans emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon...

  12. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... parameters (use appropriate units as specified in table 2 of this subpart): (1) Dioxins/furans. (2) Cadmium... stack test for dioxins/furans emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon...

  13. 40 CFR 62.15340 - What must I include in the annual report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 62.15300(a): (1) Dioxins/furans. (2) Cadmium. (3) Lead. (4) Mercury. (5) Opacity. (6) Particulate... combustion units that use activated carbon for controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent dioxins/furans and...

  14. 40 CFR 60.1400 - What must I include in my initial report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... parameters (use appropriate units as specified in table 2 of this subpart): (1) Dioxins/furans. (2) Cadmium... stack test for dioxins/furans emissions and include supporting calculations. (f) If your municipal waste combustion unit uses activated carbon to control dioxins/furans or mercury emissions, the average carbon...

  15. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... wetlands, a listing of restricted uses (along with the citations) identified in Federal, State, or local... persons with disabilities or any zero bedroom dwelling) constructed prior to 1978, provide a risk... CFR part 373, took place on the property. Hazardous substance activity includes situations where...

  16. 41 CFR 102-75.125 - What information must agencies include in the title report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... wetlands, a listing of restricted uses (along with the citations) identified in Federal, State, or local... persons with disabilities or any zero bedroom dwelling) constructed prior to 1978, provide a risk... CFR part 373, took place on the property. Hazardous substance activity includes situations where...

  17. Mosaic 18q21.2 deletions including the TCF4 gene: a clinical report.

    PubMed

    Rossi, Massimiliano; Labalme, Audrey; Cordier, Marie-Pierre; Till, Marianne; Blanchard, Gaëlle; Dubois, Remi; Guibaud, Laurent; Heissat, Sophie; Javouhey, Etienne; Lachaux, Alain; Mure, Pierre-Yves; Ville, Dorothée; Edery, Patrick; Sanlaville, Damien

    2012-12-01

    Pitt-Hopkins syndrome (PTHS) is characterized by distinctive facial dysmorphism, profound intellectual disability, and the possible occurrence of epilepsy and breathing anomalies. It is caused by haploinsufficiency of the TCF4 gene. No significant difference in clinical severity has been reported to date between PTHS patients carrying 18q21 deletions including the TCF4 gene, and those harboring TCF4 point mutations, suggesting a lack of genotype/phenotype correlation. Moreover, the size of 18q21 deletions including the TCF4 gene does not appear to have a significant effect on the phenotypic severity, suggesting that TCF4 haploinsufficiency is the most important prognostic factor in 18q deletions. We describe two unrelated patients presenting with clinical features reminiscent of PTHS and carrying mosaic interstitial 18q21 deletions characterized by array comparative genomic hybridization. One of the patients presented the lowest level of mosaic 18q21 deletion reported to date (5-10%). Our report and a review of the literature show that the mosaic status does not appear to have a significant effect on the clinical severity of 18q21 deletions, which are associated with a poor neurological outcome, whereas a mosaic TCF4 point mutation can result in a significantly milder phenotype. Malformations of internal organs are currently considered to be rare in PTHS. The patients described here had visceral anomalies, suggesting that a full morphological assessment, including heart and abdominal ultrasound scans, should be performed systematically in PTHS patients. PMID:23165966

  18. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities, and Bibliography. Revised.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.; Long, Alison T.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population matters. The document describes 15 class sessions which integrate information for sociology, anthropology, psychology, biology, animal behavior, and education. Topics include the history of human…

  19. 76 FR 10385 - Agency Information Collection Activities: Various Contract Related Forms That Will be Included in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... SECURITY Agency Information Collection Activities: Various Contract Related Forms That Will be Included in the Homeland Security Acquisition Regulation, DHS FORM 0700-01, DHS FORM 0700-02, DHS FORM 0700-03...: The Department of Homeland Security, Office of Chief Procurement Officer, Acquisition Policy...

  20. Should Physical Activity Be Included in Nutrition Education? A Comparison of Nutrition Outcomes with and without In-Class Activities

    ERIC Educational Resources Information Center

    Palmer-Keenan, Debra M.; Corda, Kirsten

    2014-01-01

    Limited-resource adults' dietary intakes and nutrition behaviors improve as a result of Expanded Food and Nutrition Education Program (EFNEP)/Supplemental Nutrition Assistance Program Education (SNAP-Ed) participation; however, physical activity education is needed for improved health. The experimental study reported here assessed if spending…

  1. Phytophthora infestans Has a Plethora of Phospholipase D Enzymes Including a Subclass That Has Extracellular Activity

    PubMed Central

    Meijer, Harold J. G.; Hassen, Hussen Harrun; Govers, Francine

    2011-01-01

    In eukaryotes phospholipase D (PLD) is involved in many cellular processes. Currently little is known about PLDs in oomycetes. Here we report that the oomycete plant pathogen Phytophthora infestans has a large repertoire of PLDs divided over six subfamilies: PXPH-PLD, PXTM-PLD, TM-PLD, PLD-likes, and type A and B sPLD-likes. Since the latter have signal peptides we developed a method using metabolically labelled phospholipids to monitor if P. infestans secretes PLD. In extracellular medium of ten P. infestans strains PLD activity was detected as demonstrated by the production of phosphatidic acid and the PLD specific marker phosphatidylalcohol. PMID:21423760

  2. Phytophthora infestans has a plethora of phospholipase D enzymes including a subclass that has extracellular activity.

    PubMed

    Meijer, Harold J G; Hassen, Hussen Harrun; Govers, Francine

    2011-01-01

    In eukaryotes phospholipase D (PLD) is involved in many cellular processes. Currently little is known about PLDs in oomycetes. Here we report that the oomycete plant pathogen Phytophthora infestans has a large repertoire of PLDs divided over six subfamilies: PXPH-PLD, PXTM-PLD, TM-PLD, PLD-likes, and type A and B sPLD-likes. Since the latter have signal peptides we developed a method using metabolically labelled phospholipids to monitor if P. infestans secretes PLD. In extracellular medium of ten P. infestans strains PLD activity was detected as demonstrated by the production of phosphatidic acid and the PLD specific marker phosphatidylalcohol. PMID:21423760

  3. Observing a fictitious stressful event: haematological changes, including circulating leukocyte activation.

    PubMed

    Mian, Rubina; Shelton-Rayner, Graham; Harkin, Brendan; Williams, Paul

    2003-03-01

    The aim of this study was to assess the effect of watching a psychological stressful event on the activation of leukocytes in healthy human volunteers. Blood samples were obtained from 32 healthy male and female subjects aged between 20 and 26 years before, during and after either watching an 83-minute horror film that none of the subjects had previously seen (The Texas Chainsaw Massacre, 1974) or by sitting quietly in a room (control group). Total differential cell counts, leukocyte activation as measured by the nitroblue tetrazolium (NBT) test, heart rate and blood pressure (BP) measurements were taken at defined time points. There were significant increases in peripheral circulating leukocytes, the number of activated circulating leukocytes, haemoglobin (Hb) concentration and haematocrit (Hct) in response to the stressor. These were accompanied by significant increases in heart rate, systolic and diastolic BP (P<0.05 from baseline). This is the first reported study on the effects of observing a psychologically stressful, albeit fictitious event on circulating leukocyte numbers and the state of leukocyte activation as determined by the nitrotetrazolium test.

  4. Active seat suspension for a small vehicle: considerations for control system including observer

    NASA Astrophysics Data System (ADS)

    Katsumata, Hiroyuki; Shiino, Hiroshi; Oshinoya, Yasuo; Ishibashi, Kazuhisa; Ozaki, Koichi; Ogino, Hirohiko

    2007-12-01

    We have examined the improvement of ride quality and the reduction of riding fatigue brought about by the active control of the seat suspension of small vehicles such as one-seater electric automobiles. A small active seat suspension, which is easy to install, was designed and manufactured for one-seater electric automobiles. For the actuator, a maintenance-free voice coil motor used as a direct drive was adopted. For fundamental considerations, we designed a one-degree-of-freedom model for the active seat suspension system. Then, we designed a disturbance cancellation control system that includes the observer for a two-degree-of-freedom model. In an actual driving test, a test road, in which the concavity and convexity of an actual road surface were simulated using hard rubber, was prepared and the control performance of vertical vibrations of the seat surface during driving was examined. As a result, in comparison with the one-degree-of-freedom control system, it was confirmed that the control performance was improved by the two-degree-of-freedom control system that includes the observer.

  5. Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage.

    PubMed

    Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Kjaer, Karina Hansen; Justesen, Just; Kelve, Merike

    2014-02-01

    2',5'-Oligoadenylate synthetases (OASs) belong to the nucleotidyl transferase family together with poly(A) polymerases, CCA-adding enzymes and the recently discovered cyclic-GMP-AMP synthase (cGAS). Mammalian OASs have been thoroughly characterized as components of the interferon-induced antiviral system. The OAS activity and the respective genes were also discovered in marine sponges where the interferon system is absent. In this study the recombinant OASs from several multicellular animals and their closest unicellular relative, a choanoflagellate, were expressed in a bacterial expression system and their enzymatic activities were examined. We demonstrated 2-5A synthesizing activities of OASs from the marine sponge Tedania ignis, a representative of the phylogenetically oldest metazoan phylum (Porifera), from an invertebrate of the protostome lineage, the mollusk Mytilus californianus (Mollusca), and from a vertebrate species, a cartilaginous fish Leucoraja erinacea (Chordata). However, the expressed proteins from an amphibian, the salamander Ambystoma mexicanum (Chordata), and from a protozoan, the marine choanoflagellate Monosiga brevicollis (Choanozoa), did not show 2-5A synthesizing activity. Differently from other studied OASs, OAS from the marine sponge T. ignis was able to catalyze the formation of oligomers having both 2',5'- and 3',5'-phosphodiester linkages. Our data suggest that OASs from sponges and evolutionarily higher animals have similar activation mechanisms which still include different affinities and possibly different structural requirements for the activating RNAs. Considering their 2'- and 3'-specificities, sponge OASs could represent a link between evolutionarily earlier nucleotidyl transferases and 2'-specific OASs from higher animals.

  6. Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage.

    PubMed

    Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Kjaer, Karina Hansen; Justesen, Just; Kelve, Merike

    2014-02-01

    2',5'-Oligoadenylate synthetases (OASs) belong to the nucleotidyl transferase family together with poly(A) polymerases, CCA-adding enzymes and the recently discovered cyclic-GMP-AMP synthase (cGAS). Mammalian OASs have been thoroughly characterized as components of the interferon-induced antiviral system. The OAS activity and the respective genes were also discovered in marine sponges where the interferon system is absent. In this study the recombinant OASs from several multicellular animals and their closest unicellular relative, a choanoflagellate, were expressed in a bacterial expression system and their enzymatic activities were examined. We demonstrated 2-5A synthesizing activities of OASs from the marine sponge Tedania ignis, a representative of the phylogenetically oldest metazoan phylum (Porifera), from an invertebrate of the protostome lineage, the mollusk Mytilus californianus (Mollusca), and from a vertebrate species, a cartilaginous fish Leucoraja erinacea (Chordata). However, the expressed proteins from an amphibian, the salamander Ambystoma mexicanum (Chordata), and from a protozoan, the marine choanoflagellate Monosiga brevicollis (Choanozoa), did not show 2-5A synthesizing activity. Differently from other studied OASs, OAS from the marine sponge T. ignis was able to catalyze the formation of oligomers having both 2',5'- and 3',5'-phosphodiester linkages. Our data suggest that OASs from sponges and evolutionarily higher animals have similar activation mechanisms which still include different affinities and possibly different structural requirements for the activating RNAs. Considering their 2'- and 3'-specificities, sponge OASs could represent a link between evolutionarily earlier nucleotidyl transferases and 2'-specific OASs from higher animals. PMID:24184688

  7. Plants as sources of airborne bacteria, including ice nucleation-active bacteria.

    PubMed

    Lindemann, J; Constantinidou, H A; Barchet, W R; Upper, C D

    1982-11-01

    Vertical wind shear and concentration gradients of viable, airborne bacteria were used to calculate the upward flux of viable cells above bare soil and canopies of several crops. Concentrations at soil or canopy height varied from 46 colony-forming units per m over young corn and wet soil to 663 colony-forming units per m over dry soil and 6,500 colony-forming units per m over a closed wheat canopy. In simultaneous samples, concentrations of viable bacteria in the air 10 m inside an alfalfa field were fourfold higher than those over a field with dry, bare soil immediately upwind. The upward flux of viable bacteria over alfalfa was three- to fourfold greater than over dry soil. Concentrations of ice nucleation-active bacteria were higher over plants than over soil. Thus, plant canopies may constitute a major source of bacteria, including ice nucleation-active bacteria, in the air.

  8. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9.

    PubMed

    Koo, Taeyoung; Lee, Jungjoon; Kim, Jin-Soo

    2015-06-01

    Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations.

  9. Stability and activity of alcohol dehydrogenases in W/O-microemulsions: enantioselective reduction including cofactor regeneration.

    PubMed

    Orlich, B; Berger, H; Lade, M; Schomäcker, R

    2000-12-20

    Microemulsions provide an interesting alternative to classical methods for the conversion of less water-soluble substrates by alcohol dehydrogenase, but until now stability and activity were too low for economically useful processes. The activity and stability of the enzymes are dependent on the microemulsion composition, mostly the water and the surfactant concentration. Therefore, it is necessary to know the exact phase behavior of a given microemulsion reaction system and the corresponding enzyme behavior therein. Because of their economic and ecologic suitability polyethoxylated fatty alcohols were investigated concerning their phase behavior and their compatibility with enzymes in ternary mixtures. The phase behavior of Marlipal O13-60 (C13EO6 in industrial quality)/cyclohexane/water and its effect on the activity and stability of alcohol dehydrogenase from Yeast (YADH) and horse liver (HLADH) and the carbonyl reductase from Candida parapsilosis (CPCR) is presented in this study. Beside the macroscopic phase behavior of the reaction system, the viscosity of the system indicates structural changes of aggregates in the microemulsion. The changes of the enzyme activities with the composition are discussed on the basis of transitions from reverse micelles to swollen reverse micelles and finally, the transition to the phase separation. The formate dehydrogenase from Candida boidinii was used for the NADH-regeneration during reduction reactions. While the formate dehydrogenase did not show any kinetic effect on the microemulsion composition, the other enzymes show significant changes of activity and stability varying the water or surfactant concentration of the microemulsion. Under certain conditions, stability could be maintained with HLADH for several weeks. Successful experiments with semi-batch processes including cofactor regeneration and product separation were performed.

  10. Molecular Beam and Surface Science Studies of Heterogeneous Reaction Kinetics Including Combustion Dynamics. Final Technical Report.

    SciTech Connect

    Sibener, S. J.

    2006-06-23

    This research program examined the heterogeneous reaction kinetics and reaction dynamics of surface chemical processes which are of direct relevance to efficient energy production, condensed phase reactions, and mateials growth including nanoscience objectives. We have had several notable scientific and technical successes. Illustrative highlights include: (1) a thorough study of how one can efficiently produce synthesis gas (SynGas) at relatively low Rh(111) catalyst temperatures via the reaction CH{sub4}+1/2 O{sub2} {r_arrow} CO+2H{sub2}. In these studies methane activation is accomplished utilizing high-kinetic energy reagents generated via supersonic molecular beams, (2) experiments which have incisively probed the partial oxidation chemistry of adsorbed 1- and 2- butene on Rh and ice, as well as partial oxidation of propene on Au; (3) investigation of structural changes which occur to the reconstructed (23x{radical}3)-Au(111) surface upon exposure to atomic oxygen, (4) a combined experimental and theoretical examination of the fundamental atomic-level rules which govern defect minimization during the formation of self-organizing stepped nanostructures, (5) the use of these relatively defect-free nanotemplates for growing silicon nanowires having atomically-dimensioned widths, (6) a combined scanning probe and atomic beam scattering study of how the presence of self-assembling organic overlayers interact with metallic supports substrates - this work hs led to revision of the currently held view of how such adsorbates reconfigure surface structure at the atomic level, (7) an inelastic He atom scattering study in which we examined the effect of chain length on the low-energy vibrations of alkanethiol striped phase self-assembled monolayers on Au(111), yielding information on the forces that govern interfacial self-assembly, (8) a study of the vibrational properties of disordered films of SF{sub6} adsorbed on Au(111), and (9) a study of the activated chemistry and

  11. RDI's Wisdom Way Solar Village Final Report: Includes Utility Bill Analysis of Occupied Homes

    SciTech Connect

    Robb Aldrich, Steven Winter Associates

    2011-07-01

    In 2010, Rural Development, Inc. (RDI) completed construction of Wisdom Way Solar Village (WWSV), a community of ten duplexes (20 homes) in Greenfield, MA. RDI was committed to very low energy use from the beginning of the design process throughout construction. Key features include: 1. Careful site plan so that all homes have solar access (for active and passive); 2. Cellulose insulation providing R-40 walls, R-50 ceiling, and R-40 floors; 3. Triple-pane windows; 4. Airtight construction (~0.1 CFM50/ft2 enclosure area); 5. Solar water heating systems with tankless, gas, auxiliary heaters; 6. PV systems (2.8 or 3.4kWSTC); 7. 2-4 bedrooms, 1,100-1,700 ft2. The design heating loads in the homes were so small that each home is heated with a single, sealed-combustion, natural gas room heater. The cost savings from the simple HVAC systems made possible the tremendous investments in the homes' envelopes. The Consortium for Advanced Residential Buildings (CARB) monitored temperatures and comfort in several homes during the winter of 2009-2010. In the Spring of 2011, CARB obtained utility bill information from 13 occupied homes. Because of efficient lights, appliances, and conscientious home occupants, the energy generated by the solar electric systems exceeded the electric energy used in most homes. Most homes, in fact, had a net credit from the electric utility over the course of a year. On the natural gas side, total gas costs averaged $377 per year (for heating, water heating, cooking, and clothes drying). Total energy costs were even less - $337 per year, including all utility fees. The highest annual energy bill for any home evaluated was $458; the lowest was $171.

  12. [NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 5:] Summary report to phase 1 respondents including frequency distributions

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 1 of a four part study was undertaken to investigate the use of scientific and technical information (STI) by U.S. aerospace engineers and scientists. Specific attention was paid to institutional and sociometric variables and to the step-by-step process of information gathering used by the respondents. Data were collected by means of three self-administered mail-back questionnaires. The approximately 34,000 members of the American Institute of Aeronautics and Astronautics served as the study population. More than 65 percent of the randomly selected respondants returned the questionnaires in each of the three groups. Respondants relied more heavily on informal sources of information than formal sources and turned to librarians and other technical information specialists only when they did not obtain results via informal means or their own formal searches. The report includes frequency distributions for the questions.

  13. Active Matrix OLED Test Report

    NASA Technical Reports Server (NTRS)

    Salazar, George

    2013-01-01

    This report focuses on the limited environmental testing of the AMOLED display performed as an engineering evaluation by The NASA Johnson Space Center (JSC)-specifically. EMI. Thermal Vac, and radiation tests. The AMOLED display is an active-matrix Organic Light Emitting Diode (OLED) technology. The testing provided an initial understanding of the technology and its suitability for space applications. Relative to light emitting diode (LED) displays or liquid crystal displays (LCDs), AMOLED displays provide a superior viewing experience even though they are much lighter and smaller, produce higher contrast ratio and richer colors, and require less power to operate than LCDs. However, AMOLED technology has not been demonstrated in a space environment. Therefore, some risks with the technology must be addressed before they can be seriously considered for human spaceflight. The environmental tests provided preliminary performance data on the ability of the display technology to handle some of the simulated induced space/spacecraft environments that an AMOLED display will see during a spacecraft certification test program. This engineering evaluation is part of a Space Act Agreement (SM) between The NASA/JSC and Honeywell International (HI) as a collaborative effort to evaluate the potential use of AMOLED technology for future human spaceflight missions- both government-led and commercial. Under this SM, HI is responsible for doing optical performance evaluation, as well as temperature and touch screen studies. The NASA/JSC is responsible for performing environmental testing comprised of EMI, Thermal Vac, and radiation tests. Additionally, as part of the testing, limited optical data was acquired to assess performance as the display was subjected to the induced environments. The NASA will benefit from this engineering evaluation by understanding AMOLED suitability for future use in space as well as becoming a smarter buyer (or developer) of the technology. HI benefits

  14. The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

    PubMed Central

    Mock, Kerstin; Preca, Bogdan-Tiberius; Brummer, Tilman; Brabletz, Simone; Stemmler, Marc P.; Brabletz, Thomas

    2015-01-01

    Tumor cell invasion, dissemination and metastasis is triggered by an aberrant activation of epithelial-to-mesenchymal transition (EMT), often mediated by the transcription factor ZEB1. Disseminating tumor cells must acquire specific features that allow them to colonize at different organ sites. Here we identify a set of genes that is highly expressed in breast cancer bone metastasis and activated by ZEB1. This gene set includes various secreted factors, e.g. the BMP-inhibitor FST, that are described to reorganize the bone microenvironment. By inactivating BMP-signaling, BMP-inhibitors are well-known to induce osteolysis in development and disease. We here demonstrate that the expression of ZEB1 and BMP-inhibitors is correlated with bone metastasis, but not with brain or lung metastasis of breast cancer patients. In addition, we show that this correlated expression pattern is causally linked, as ZEB1 induces the expression of the BMP-inhibitors NOG, FST and CHRDL1 both by directly increasing their gene transcription, as well as by indirectly suppressing their reduction via miR-200 family members. Consequently, ZEB1 stimulates BMP-inhibitor mediated osteoclast differentiation. These findings suggest that ZEB1 is not only driving EMT, but also contributes to the formation of osteolytic bone metastases in breast cancer. PMID:25973542

  15. Composting of soils/sediments and sludges containing toxic organics including high energy explosives. Final report

    SciTech Connect

    Doyle, R.C.; Kitchens, J.F.

    1993-07-01

    Laboratory and pilot-scale experimentation were conducted to evaluate composting as an on-site treatment technology to remediate soils contaminated with hazardous waste at DOE`s PANTEX Plant. Suspected contaminated sites within the PANTEX Plant were sampled and analyzed for explosives, other organics, and inorganic wastes. Soils in drainage ditches and playas at PANTEX Plant were found to be contaminated with low levels of explosives (including RDX, HMX, PETN and TATB). Additional sites previously used for solvent disposal were heavily contaminated with solvents and transformation products of the solvent, as well as explosives and by-products of explosives. Laboratory studies were conducted using {sup 14}C-labeled explosives and {sup 14}C-labeled diacetone alcohol contaminated soil loaded into horse manure/hay composts at three rates: 20, 30, and 40%(W/W). The composts were incubated for six weeks at approximately 60{degree}C with continuous aeration. All explosives degraded rapidly and were reduced to below detection limits within 3 weeks in the laboratory studies. {sup 14}C-degradates from {sup 14}C-RDX, {sup 14}C-HMX and {sup 14}C-TATB were largely limited to {sup 14}CO{sub 2} and unextracted residue in the compost. Volatile and non-volatile {sup 14}C-degradates were found to result from {sup 14}C-PETN breakdown, but these compounds were not identified. {sup 14}C-diacetone alcohol concentrations were significantly reduced during composting. However, most of the radioactivity was volatilized from the compost as non-{sup 14}CO{sub 2} degradates or as {sup 14}C-diacetone alcohol. Pilot scale composts loaded with explosives contaminated soil at 30% (W/W) with intermittent aeration were monitored over six weeks. Data from the pilot-scale study generally was in agreement with the laboratory studies. However, the {sup 14}C-labeled TATB degraded much faster than the unlabeled TATB. Some formulations of TATB may be more resistant to composting activity than others.

  16. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Performance for Commercial and Industrial Solid Waste Incineration Units Recordkeeping and Reporting § 60.2210... accordance with the procedure in 40 CFR part 60, appendix F of this part, as if any of the following...

  17. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... cause of deviations (including unknown cause, if applicable), as applicable, and the corrective action... that are due to control equipment problems, process problems, other known causes, and other...

  18. 32 CFR 37.880 - What requirements must I include for periodic reports on program and business status?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (a) The requirements in 32 CFR 32.51 and 32.52 for status reports on programmatic performance and, if...), including an accounting of expenditures for the period covered by the report. The report should compare the... program official, judge that those additional details are needed for good stewardship....

  19. Be BOLD: Encouraging Girls to Include Unstructured Bouts of Physical Activity into Daily Routines

    ERIC Educational Resources Information Center

    Hill, Kory; Williams, Gwynne M.

    2014-01-01

    Adolescent girls are less active than their male counterparts and physical activity levels tend to decline as one ages. One of the goals of concerned physical educators is to promote a physically active lifestyle and to teach skills and promote behaviors that will allow students to be active both in and out of school. This article presents a…

  20. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... user, the added and revised text is set forth as follows: § 60.2770 What information must I include in...) Information on the number, duration, and cause of deviations (including unknown cause, if applicable), as... problems, other known causes, and other unknown causes. (7) A summary of the total duration of...

  1. Active control of environmental noise, VIII: increasing the response to primary source changes including unpredictable noise

    NASA Astrophysics Data System (ADS)

    Wright, S. E.; Atmoko, H.; Vuksanovic, B.

    2004-07-01

    Conventional adaptive cancellation systems using traditional transverse finite impulse response (FIR) filters, together with least mean square (LMS) adaptive algorithms, well known in active noise control, are slow to adapt to primary source changes. This makes them inappropriate for cancelling rapidly changing noise, including unpredictable noise such as speech and music. Secondly, the cancelling structures require considerable computational processing effort to adapt to primary source and plant changes, particularly for multi-channel systems. This paper describes methods to increase the adaptive speed to primary source changes in large enclosed spaces and outdoor environments. A method is described that increases the response to time varying periodic noise using traditional transverse FIR filters. Here a multi-passband filter, with individual variable adaptive step sizes for each passband is automatically adjusted according to the signal level in each band. This creates a similar adaptive response for all frequencies within the total pass-band, irrespective of amplitude, minimizing the signal distortion and increasing the combined adaptive speed. Unfortunately, there is a limit to the adaptive speed using the above method as classical transverse FIR filters have a finite adaptive speed given by the stability band zero bandwidth. For rapidly changing periodic noise and unpredictable non-stationary noise, a rapid to instantaneous response is required. In this case the on-line adaptive FIR filters are dispensed with and replaced by a time domain solution that gives virtually instantaneous cancellation response (infinite adaptive speed) to primary source changes, and is computationally efficient.

  2. Surface water treatment rule. Implementation manual (including Appendix D). Final report

    SciTech Connect

    Not Available

    1990-03-08

    The purpose of the document is to provide guidance to EPA regions and the States on implementation of the rule. More specifically, the document addresses violation determination, FRDS reporting, and the State Primacy Revision Application. The document differs from the Guidance Manual for Compliance with the Filtration and Disinfection Requirements for Public Water Systems using Surface Water Sources, October 1989 (referred to hereafter as the SWTR Guidance Manual) in that the SWTR Guidance Manual deals with PWS treatment techniques and measurement methods rather than primacy and reporting requirements.

  3. In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains.

    PubMed

    Kohira, Naoki; West, Joshua; Ito, Akinobu; Ito-Horiyama, Tsukasa; Nakamura, Rio; Sato, Takafumi; Rittenhouse, Stephen; Tsuji, Masakatsu; Yamano, Yoshinori

    2015-11-16

    S-649266 is a novel siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. Two sets of clinical isolate collections were used to evaluate the antimicrobial activity of S-649266 against Enterobacteriaceae. These sets included 617 global isolates collected between 2009 and 2011 and 233 β-lactamase-identified isolates, including 47 KPC-, 49 NDM-, 12 VIM-, and 8 IMP-producers. The MIC90 values of S-649266 against the first set of Escherichia coli, Klebsiella pneumoniae, Serratia marcescens, Citrobacter freundii, Enterobacter aerogenes, and Enterobacter cloacae isolates were all ≤1 μg/ml, and there were only 8 isolates (1.3%) among these 617 clinical isolates with MIC values of ≥8 μg/ml. In the second set, the MIC values of S-649266 were ≤4 μg/ml against 109 strains among 116 KPC-producing and class B (metallo) carbapenemase-producing strains. In addition, S-649266 showed MIC values of ≤2 μg/ml against each of the 13 strains that produced other types of carbapenemases such as SME, NMC, and OXA-48. The mechanisms of the decreased susceptibility of 7 class B carbapenemase-producing strains with MIC values of ≥16 μg/ml are uncertain. This is the first report to demonstrate that S-649266, a novel siderophore cephalosporin, has significant antimicrobial activity against Enterobacteriaceae, including strains that produce carbapenemases such as KPC and NDM-1.

  4. Square One TV Content Analysis: Final Report (Including Season Five Show Rundowns).

    ERIC Educational Resources Information Center

    Schneider, Joel; And Others

    This report summarizes the mathematical and pedagogical content of the 230 programs in the SQUARE ONE TV library after five seasons of production, relating that content to the three goals of the series: (1) to promote positive attitudes toward, and enthusiasm for, mathematics; (2) to encourage the use and application of problem-solving processes;…

  5. 77 FR 65582 - Quad Graphics, Inc., Including Workers Whose Wages Were Reported Under Quad Graphics Printing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... Quad Graphics Printing Corp. and Quad Logistics Services, Effingham, IL; Amended Certification... wages reported under Quad Graphics, Inc., Quad Graphics Printing Corp., and Quad Logistics Services. The... Graphics Printing Corp. and Quad Logistics Services (TA-W-73,441H), who became totally or...

  6. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  7. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  8. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  9. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  10. 45 CFR 287.130 - Can NEW Program activities include job market assessments, job creation and economic development...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Can NEW Program activities include job market assessments, job creation and economic development activities? 287.130 Section 287.130 Public Welfare... Program Design and Operations § 287.130 Can NEW Program activities include job market assessments,...

  11. Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells.

    PubMed

    Thougaard, Annemette V; Christiansen, Joan; Mow, Tomas; Hornberg, Jorrit J

    2014-12-01

    Genotoxicity is an unacceptable property for new drug candidates and we employ three screening assays during the drug discovery process to identify genotoxicity early and optimize chemical series. One of these methods is the flow cytometric in vitro micronucleus assay for which protocol optimizations have been described recently. Here, we report further validation of the assay in TK6 cells including assessment of metabolic activation. We first optimized assay conditions to allow for testing with and without metabolic activation in parallel in a 96-well plate format. Then, we tested a set of 48 compounds carefully selected to contain known in vivo genotoxins, nongenotoxins and drugs. Avoidance of irrelevant positives, a known issue with mammalian cell-based genotoxicity assays, is important to prevent early deselection of potentially promising compounds. Therefore, we enriched the validation set with compounds that were previously reported to produce irrelevant positive results in mammalian cell-based genotoxicity assays. The resulting dataset was used to set the relevant cut-off values for scoring a compound positive or negative, such that we obtained an optimal balance of high sensitivity (88%) and high specificity (87%). Finally, we tested an additional set of 16 drugs to further probe assay performance and 14 of them were classified correctly. To our knowledge, the present study is the most comprehensive validation of the in vitro flow cytometric micronucleus assay and the first to report parallel assessment with metabolic activation in reasonable throughput. The assay allows for rapidly screening novel compounds for genotoxicity and is therefore well-suited for use in early drug discovery projects. Environ.

  12. Report says Gulf of Mexico oil spill assessment should include ecosystem services approach

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2011-11-01

    The oil spill in the Gulf of Mexico that resulted from the 20 April 2010 explosion of the Deepwater Horizon (DWH) platform drilling the Macondo well was so massive and affected such a large and deep region of the gulf that the process of determining environmental damage in the region should be more encompassing than a typical habitat and resource equivalency approach, according to a 9 November report by the U.S. National Research Council (NRC). The congressionally requested report calls for an ecosystem services approach to complement ongoing approaches to the damage evaluation for the spill that is being conducted through the ongoing Natural Resources Damage Assessment (NRDA) process triggered by the U.S. Oil Pollution Act (OPA) of 1990.

  13. Activities report in applied physics

    NASA Astrophysics Data System (ADS)

    Research concerning acoustics, heat, architecture, materials research, and (optical) instrumentation is presented; active noise control and acoustic path identification were investigated. Energy conservation, solar energy, and building physics activities were carried out. Ultraviolet absorbing glasses, glass fibers, sheet glass, and aluminium and silicon oxynitrides, were studied. Glass fiber based sensor and laser applications, and optical space-instrumentation are discussed. Signal processing, sensors, and integrated electronics applications were developed. Scale model experiments for flow induced noise and vibrations, caused by engines, ventilators, wind turbines, and propellers, were executed. A multispectral charge coupled device airborne scanner, with four modules (one for forward observations) is described. A ground radar, based on seismic exploration signal processing and used for the location of pipes, sewers and cables, was developed.

  14. Activities report of PTT Research

    NASA Astrophysics Data System (ADS)

    In the field of postal infrastructure research, activities were performed on postcode readers, radiolabels, and techniques of operations research and artificial intelligence. In the field of telecommunication, transportation, and information, research was made on multipurpose coding schemes, speech recognition, hypertext, a multimedia information server, security of electronic data interchange, document retrieval, improvement of the quality of user interfaces, domotics living support (techniques), and standardization of telecommunication prototcols. In the field of telecommunication infrastructure and provisions research, activities were performed on universal personal telecommunications, advanced broadband network technologies, coherent techniques, measurement of audio quality, near field facilities, local beam communication, local area networks, network security, coupling of broadband and narrowband integrated services digital networks, digital mapping, and standardization of protocols.

  15. 40 CFR 60.1410 - What must I include in my annual report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., nitrogen oxides emissions. (3) Carbon monoxide emissions. (4) Load level of the municipal waste combustion... mercury emissions, include four records: (1) The average carbon feed rates recorded during the most recent... only, nitrogen oxides emissions. (3) Carbon monoxide emissions. (4) Load level of the municipal...

  16. 40 CFR 60.1885 - What must I include in my annual report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... municipal waste combustion units only, nitrogen oxides emissions. (3) Carbon monoxide emissions. (4) Load... controlling dioxins/furans or mercury emissions, include four records: (1) The average carbon feed rates... waste combustion units only, nitrogen oxides emissions. (3) Carbon monoxide emissions. (4) Load level...

  17. 76 FR 10395 - First American Title Insurance Company, Including Workers Whose Wages Were Reported Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Register on November 23, 2010 (75 FR 71460). At the request of the State agency, the Department reviewed... Professional Staffing and Remedy/ Select, Waterloo, IA; Amended Certification Regarding Eligibility To Apply..., including on-site leased workers from, Remedy/Select, Waterloo, Iowa. The workers supplied...

  18. 76 FR 2712 - Ocwen Loan Servicing, LLC, Including Workers Whose Wages Were Reported Under Barclays Capital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Register on December 8, 2010 (75 FR 76488). The notice as amended on December 17, 2010 to include workers... January 3, 2011 (76 FR 178). At the request of the company, the Department reviewed the certification for... amending this certification to properly reflex this matter. The intent of the Department's certification...

  19. 40 CFR 60.2770 - What information must I include in my annual report?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28661, May 18, 2011, the amendment was delayed indefinitely. For the convenience of the user, the added... the number, duration, and cause of deviations (including unknown cause, if applicable), as applicable... problems, other known causes, and other unknown causes. (7) A summary of the total duration of...

  20. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (including unknown cause, if applicable), as applicable, and the corrective action taken. (m) If there were... that are due to control equipment problems, process problems, other known causes, and other unknown... procedure in 40 CFR part 60, appendix F of this part, as if any of the following occur. (1) The zero...

  1. 40 CFR 60.2210 - What information must I include in my annual report?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... user, the added and revised text is set forth as follows: § 60.2210 What information must I include in... unknown cause, if applicable), as applicable, and the corrective action taken. (m) If there were periods... that are due to control equipment problems, process problems, other known causes, and other...

  2. Using Assistive Technology Adaptations To Include Students with Learning Disabilities in Cooperative Learning Activities.

    ERIC Educational Resources Information Center

    Bryant, Diane Pedrotty; Bryant, Brian R.

    1998-01-01

    Discusses a process for integrating technology adaptations for students with learning disabilities into cooperative-learning activities in terms of three components: (1) selecting adaptations; (2) monitoring use of adaptations during cooperative-learning activities; and (3) evaluating the adaptations' effectiveness. Barriers to and support systems…

  3. Poikiloderma with neutropenia: report of three cases including one with calcinosis cutis.

    PubMed

    Chantorn, Rattanavalai; Shwayder, Tor

    2012-01-01

    Poikiloderma with neutropenia (PN), Clericuzio type (OMIM #604173) is a new, unique genodermatosis first described by Clericuzio et al (Am J Med Genet A, 2011, 155, 337) in Navajo Indian population. This disease is characterized by poikiloderma that usually develops in the first year of life and is associated with nail abnormality, palmoplantar hyperkeratosis, chronic neutropenia, and recurrent infections. The rash typically starts from the extremities and spreads centripetally to involve the trunk, face, and ears. Recently, a homozygous mutation in the C16orf57 gene on chromosome 16q13 was identified as a strong candidate as the gene responsible for PN. We report three cases of PN whose clinical presentations, laboratory investigations, and C16orf57 mutation support the diagnosis of PN. One child has developed multiple painful calcinosis cutis lesions. Early-onset poikiloderma should prompt a complete blood count as a screening test. PMID:21967010

  4. Women convicted of a sexual offence, including child pornography production: two case reports.

    PubMed

    Prat, S; Bertsch, I; Chudzik, L; Réveillère, Ch

    2014-03-01

    All available studies addressing the clinical and legal aspects of child pornography have systematically concerned male abusers. The social lens through which women are viewed tends to play down their responsibility in the sexual abuse of children. Unlike men, women rarely abuse children outside the close or family circle. Furthermore, they have frequently been abused themselves in their childhood. To our knowledge, no cases of women charged with sex-related offences, including child pornography, have been described in the literature. The psychopathological characteristics of female sexual abusers and of the two women in our cases tend to suggest that the deliberate downloading of child pornography images by women is unusual, as their deviant behaviour is not related to paedophile sexual arousal It is hypothesized that the act enables women perpetrators to satisfy the sexual urges of their spouse. Sexual abuse by women exists, but the nature of the abuse appears to be specific to the gender of the perpetrator. We present two cases of women charged with sexual offences concerning minors, including the production of child pornography material. PMID:24661700

  5. Women convicted of a sexual offence, including child pornography production: two case reports.

    PubMed

    Prat, S; Bertsch, I; Chudzik, L; Réveillère, Ch

    2014-03-01

    All available studies addressing the clinical and legal aspects of child pornography have systematically concerned male abusers. The social lens through which women are viewed tends to play down their responsibility in the sexual abuse of children. Unlike men, women rarely abuse children outside the close or family circle. Furthermore, they have frequently been abused themselves in their childhood. To our knowledge, no cases of women charged with sex-related offences, including child pornography, have been described in the literature. The psychopathological characteristics of female sexual abusers and of the two women in our cases tend to suggest that the deliberate downloading of child pornography images by women is unusual, as their deviant behaviour is not related to paedophile sexual arousal It is hypothesized that the act enables women perpetrators to satisfy the sexual urges of their spouse. Sexual abuse by women exists, but the nature of the abuse appears to be specific to the gender of the perpetrator. We present two cases of women charged with sexual offences concerning minors, including the production of child pornography material.

  6. 43 CFR 3276.11 - What information must I include for each well in the monthly report of well operations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... information must I include for each well in the monthly report of well operations? (a) Any drilling operations or changes made to a well; (b) Total production or injection in thousands of pounds (klbs); (c... well in the monthly report of well operations? 3276.11 Section 3276.11 Public Lands:...

  7. 32 CFR 37.880 - What requirements must I include for periodic reports on program and business status?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...: (a) The requirements in 32 CFR 32.51 and 32.52 for status reports on programmatic performance and, if it is an expenditure-based award, on financial performance; or (b) Alternative requirements that, as a minimum, include periodic reports addressing program and, if it is an expenditure-based...

  8. Retrorectal cystic hamartoma. Report of three cases, including one with a perirenal component.

    PubMed

    Mills, S E; Walker, A N; Stallings, R G; Allen, M S

    1984-09-01

    Retrorectal cystic hamartomas (RCHs) are uncommon lesions of controversial pathogenesis that arise in the presacrococcygeal space. We describe the clinicopathologic features of RCHs from three adult patients. Two were asymptomatic women; the third was a man who had a pelvic abscess. All three specimens were multiloculated cysts lined by squamous, transitional, and glandular epithelium. Poorly organized collections of smooth muscle were present in the surrounding connective tissue, but no well-formed smooth-muscle coat was seen. Although RCHs possess elements of three germ-cell layers, their histologic features are similar to those of the embryonic tailgut. The male patient also had a perirenal mass that was grossly and histologically identical to the RCH. The associated kidney was malrotated. A portion of the embryonic tailgut may have been pulled cephalad by the developing kidney, inhibiting its rotation. Clinicopathologic features distinguish RCH from other retrorectal cystic lesions, including teratoma, dermoid, epidermal cyst, rectal duplication, anal duplication, and anal gland cyst.

  9. Oncocytic neoplasms of salivary glands: a report of fifteen cases including two malignant oncocytomas.

    PubMed

    Gray, S R; Cornog, J L; Seo, I S

    1976-09-01

    Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are 10 benign oncocytomas, two malignant oncocytomas and three benign, oncocytic pleomorphic adenomas. The clinical and pathologic features of benign oncocytomas are reviewed, with special attention to the variety of gross and microscopic changes present. The literature on malignant oncocytomas is critically reviewed, diagnostic criteria are evaluated, and a unique case is discussed in detail. Reference is made to a group of neoplasms that we designate as benign locally aggressive oncocytomas. The problem of differential diagnosis between oncocytoma and bening, oncocytic pleomorphic adenoma is considered.

  10. Summary reports of activities under visiting research program, 1993

    NASA Astrophysics Data System (ADS)

    1993-10-01

    The summary reports of activities under visiting research program in the Research Reactor Institute, Kyoto University, in fiscal year 1992 are included. In this report, 104 summaries of researches using the Kyoto University Reactor (KUR) and 9 summaries of the researches using the Kyoto University Critical Assembly (KUCA) are collected.

  11. Needs assessment activity report: Fiscal year 1995

    SciTech Connect

    1995-09-01

    The Needs Assessment program has assessed the packaging requirements of many U.S. Department of Energy (DOE) sites. These assessments have involved site visits and meetings with personnel involved with transportation and packaging of hazardous materials. By September 1995, 24 DOE facilities had been visited, with 14 site visits occurring in fiscal year 1995. As a result, these sites have been informed of some of the packaging activities that DOE has sponsored and is sponsoring, have been apprised of the affects of upcoming changes to transportation regulations, have discussed their near-term packaging needs, and have shared unique packaging they have developed, which may be of use to other DOE facilities. Program successes include discovery of a need for a reusable Type A liquid sample packaging and its development within another DOE task and establishing communications pathways between DOE sites that have similar transportation and packaging needs. This report recommends that the Needs Assessment activity continue to pursue the strategy of visiting DOE sites to meet with their transportation and packaging personnel. These visits will ensure that DOE needs are met, communications pathways between DOE sites are established and cultivated, and redundant packaging development is identified. The site visits should be expanded to include meetings with the long-range and strategic planners at each site, and at the DOE-Headquarters level, to ensure that all future transportation and packaging needs are identified early enough to allow adequate transportation assessment and packaging development. This activity could become a permanent conduit for information and will ensure that all future DOE transportation and packaging needs are satisfied in a cost-effective, timely, and efficient manner.

  12. Diffractive laser beam homogenizer including a photo-active material and method of fabricating the same

    SciTech Connect

    Bayramian, Andy J; Ebbers, Christopher A; Chen, Diana C

    2014-05-20

    A method of manufacturing a plurality of diffractive optical elements includes providing a partially transmissive slide, providing a first piece of PTR glass, and directing first UV radiation through the partially transmissive slide to impinge on the first piece of PTR glass. The method also includes exposing predetermined portions of the first piece of PTR glass to the first UV radiation and thermally treating the exposed first piece of PTR glass. The method further includes providing a second piece of PTR glass and directing second UV radiation through the thermally treated first piece of PTR glass to impinge on the second piece of PTR glass. The method additionally includes exposing predetermined portions of the second piece of PTR glass to the second UV radiation, thermally treating the exposed second piece of PTR glass, and repeating providing and processing of the second piece of PTR glass using additional pieces of PTR glass.

  13. In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.

    PubMed

    Fujisaki, Ryuichi; Kamei, Kiyoko; Yamamura, Mariko; Nishiya, Hajime; Inouye, Shigeharu; Takahashi, Miki; Abe, Shigeru

    2012-03-01

    Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values. PMID:23082579

  14. In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.

    PubMed

    Fujisaki, Ryuichi; Kamei, Kiyoko; Yamamura, Mariko; Nishiya, Hajime; Inouye, Shigeharu; Takahashi, Miki; Abe, Shigeru

    2012-03-01

    Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai) and 2 constituents (thymoquinone and hinokitiol) were found to be active against P. falciparum in vitro, with 50% inhibitory concentration (IC50) values equal to or less than 1.0 microg/ml. Furthermore, in vivo analysis using a rodent model confirmed the anti-plasmodial potential of subcutaneously administered sandalwood oil, and percutaneously administered hinokitiol and caraway oil against rodent P. berghei. Notably, these oils showed no efficacy when administered orally, intraperitoneally or intravenously. Caraway oil and hinokitiol dissolved in carrier oil, applied to the skin of hairless mice caused high levels in the blood, with concentrations exceeding their IC50 values.

  15. Electrode including porous particles with embedded active material for use in a secondary electrochemical cell

    DOEpatents

    Vissers, Donald R.; Nelson, Paul A.; Kaun, Thomas D.; Tomczuk, Zygmunt

    1978-04-25

    Particles of carbonaceous matrices containing embedded electrode active material are prepared for vibratory loading within a porous electrically conductive substrate. In preparing the particles, active materials such as metal chalcogenides, solid alloys of alkali or alkaline earth metals along with other metals and their oxides in powdered or particulate form are blended with a thermosetting resin and particles of a volatile to form a paste mixture. The paste is heated to a temperature at which the volatile transforms into vapor to impart porosity at about the same time as the resin begins to cure into a rigid, solid structure. The solid structure is then comminuted into porous, carbonaceous particles with the embedded active material.

  16. NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 7:Summary report to phase 2 respondents including frequency distributions

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 2 of the four phase NASA/DoD Aerospace Knowledge Diffusion Research Project was undertaken to study the transfer of scientific and technical information (STI) from government to the aerospace industry and the role of librarians and technical information specialists in the transfer process. Data was collected through a self-administered mailback questionnaire. Libraries identified as holding substantial aerospace or aeronautical technical report collections were selected to receive the questionnaires. Within each library, the person responsible for the technical report was requested to answer the questionnaire. Questionnaires were returned from approx. 68 pct. of the libraries. The respondents indicated that scientists and engineer are not aware of the services available from libraries/technical information centers and that scientists and engineers also under-utilized their services. The respondents also indicated they should be more involved in the process.

  17. WCOTP Annual Report 1978; Including the Formal Documents of the XXVII Assembly of Delegates, Jakarta, Indonesia, July 26-August 2, 1978.

    ERIC Educational Resources Information Center

    World Confederation of Organizations of the Teaching Profession, Morges (Switzerland).

    Included in this annual report are: (1) a review of WCOTP activities presented on behalf of the executive committee; (2) resolutions passed by the XXVII Assembly of Delegates; (3) the program and budget for 1979-80; (4) WCOTP constitution and bylaws; (5) the financial statement for calendar year 1977; and (6) the WCOTP membership list. (DS)

  18. The Otosclerosis Problem: including Reports of Two Cases Pathologically Examined (Dalby Memorial Lecture)

    PubMed Central

    Gray, Albert A.

    1934-01-01

    The essential causative factor of otosclerosis is a gradually increasing defect in the vasomotor mechanism which governs the nutrition of the structures of the organ of hearing as a whole. The axon reflexes are, of course, included in this vasomotor mechanism, and the stimulus which excites the vasomotor mechanism is sound and sound alone. Consequently the vestibular apparatus and the semicircular canals are unaffected in otosclerosis. There is no evidence whatever of any defect in any of the endocrine glands or their secretions in otosclerosis. Neither is there any evidence of any defect in the bone metabolism of the body. On the contrary the subjects of otosclerosis are, apart from their deafness, perfectly normal individuals with ordinary average health. The deafness of otosclerosis bears very little relationship to the extent of the disease in the bone. The deafness may be very severe when the stapes is hardly fixed at all. The severity of the tinnitus bears no relationship at all to the extent of the disease in the bone. The extent of the change in the bone bears very little relationship to the duration of the disease. The extent of the changes in the bone appears to depend upon the age of onset of the disease. The earlier in life that the otosclerosis begins, the more extensive will the bone lesion become. The deafness of otosclerosis is to a large extent functional, and is the result of the insufficient supply of blood to all the nerve-structures concerned in the perception of sound. The preponderance of women as subjects of otosclerosis is the result of the greater instability of their vasomotor system and the more frequent disturbances to which it is exposed. The changes in the bone show a remarkable bilateral symmetry even to minute details. This symmetrical distribution is readily explained by the writer's view of the causative factor of otosclerosis. The vasomotor nerves governing the nutrition of the organ of hearing are anatomically symmetrical like

  19. Physical Activity Programs in Higher Education: Modifying Net/Wall Games to Include Individuals with Disabilities

    ERIC Educational Resources Information Center

    Braga, Luciana; Tracy, Julia F.; Taliaferro, Andrea R.

    2015-01-01

    The growing number of students with disabilities in higher education settings has presented challenges for instructors with regards to appropriate inclusion. Concerning physical activity courses in higher education, instructors may not have the knowledge or resources to make modifications and accommodations that will ultimately result in…

  20. Sixty Minutes of Physical Activity per Day Included within Preschool Academic Lessons Improves Early Literacy

    ERIC Educational Resources Information Center

    Kirk, Stacie M.; Kirk, Erik P.

    2016-01-01

    Background: The effects of increases in physical activity (PA) on early literacy skills in preschool children are not known. Methods: Fifty-four African-American preschool children from a low socioeconomic urban Head Start participated over 8 months. A 2-group, quasi-experimental design was used with one preschool site participating in the PA…

  1. Population and Human Development: A Course Curriculum Including Lesson Plans, Activities and Bibliography.

    ERIC Educational Resources Information Center

    Murphy, Elaine M.

    This course outline suggests materials and learning activities on the interrelated causes and consequences of population growth and other population concerns. Designed to educate general college audiences, it is also intended for use as a preservice course for teachers. In addition, the course can be modified for high school students. The course…

  2. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  3. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  4. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  5. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...

  6. Backyards and Butterflies: Ways to Include Children with Disabilities in Outdoor Activities.

    ERIC Educational Resources Information Center

    Greenstein, Doreen; And Others

    This sourcebook is designed for children, parents, and families, detailing ideas for outdoor play and learning activities, with emphasis on involving children with disabilities in outdoor play. A rural perspective permeates the guide, although each chapter contains ideas for making outdoor environments more accessible and safer for all children,…

  7. Beyond Right or Wrong: Challenges of Including Creative Design Activities in the Classroom

    ERIC Educational Resources Information Center

    Brennan, Karen

    2015-01-01

    In this article, we explore challenges encountered by K-12 educators in establishing classroom cultures that support creative learning activities with the Scratch programming language. Providing opportunities for students to understand and to build capacities for creative work was described by many of the teachers that we interviewed as a central…

  8. Low-rank coal research annual report, July 1, 1989--June 30, 1990 including quarterly report, April--June 1990

    SciTech Connect

    Not Available

    1990-11-01

    Research programs in the following areas are presented: control technology and coal preparation; advance research and technology development; combustion; liquefaction; and gasification. Sixteen projects are included. Selected items have been processed separately for inclusion in the Energy Science and Technology Database.

  9. Space Resources for Teachers: Biology, Including Suggestions for Classroom Activities and Laboratory Experiments.

    ERIC Educational Resources Information Center

    Lee, Tom E.; And Others

    This compilation of resource units concerns the latest developments in space biology. Some of the topics included are oxygen consumption, temperature, radiation, rhythms, weightlessness, acceleration and vibration stress, toxicity, and sensory and perceptual problems. Many of the topics are interdisciplinary and relate biology, physiology,…

  10. 7 CFR 981.441 - Credit for market promotion activities, including paid advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... relations purposes, including E-commerce (mail ordering through the Internet): Provided, That Credit-Back...-Back is requested. (e) The following requirements shall apply to Credit-Back for all promotional... and Canada, paragraph (e)(5) of this section shall also apply. (2) The clear and evident purpose...

  11. In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp.

    PubMed

    Olsen, Steven C; Carlson, Steve A

    2015-01-01

    Plazomicin is a next-generation aminoglycoside with a potentially unique set of clinical characteristics compared with other aminoglycosides. This study assessed the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of plazomicin against 15 clinical isolates as well as three reference strains representing Brucella abortus, Brucella melitensis and Brucella suis. These data were compared with those obtained for six other aminoglycosides and two aminocyclitols. Plazomicin and gentamicin were the only drugs demonstrating bactericidal activity towards two of the three Brucella spp., whilst plazomicin was the only drug exhibiting bactericidal activity against B. suis. This is the first study to assess the bactericidal nature of plazomicin against Brucella spp. in vitro. PMID:25459738

  12. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...)) show emissions above the limits specified in table 1 of this subpart for dioxins/furans, cadmium, lead... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1... mercury and dioxins/furans stack test (as specified in § 60.1370(a)(1)). Include four items: (i)...

  13. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...)) show emissions above the limits specified in table 1 of this subpart for dioxins/furans, cadmium, lead... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1... mercury and dioxins/furans stack test (as specified in § 60.1370(a)(1)). Include four items: (i)...

  14. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...)) show emissions above the limits specified in table 1 of this subpart for dioxins/furans, cadmium, lead... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1... mercury and dioxins/furans stack test (as specified in § 60.1370(a)(1)). Include four items: (i)...

  15. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...)) show emissions above the limits specified in table 1 of this subpart for dioxins/furans, cadmium, lead... units that apply activated carbon to control dioxins/furans or mercury emissions, include two items: (1... mercury and dioxins/furans stack test (as specified in § 60.1370(a)(1)). Include four items: (i)...

  16. General aviation activity survey. Annual summary report for 1992

    SciTech Connect

    Not Available

    1992-01-01

    This report presents the results of the annual General Aviation Activity Survey. The survey is conducted by the FAA to obtain information on the flight activity of the United States registered general aviation aircraft fleet. The report contains breakdowns of active aircraft, annual flight hours, average flight hours and other statistics by manufacturer/model group, aircraft type, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, engine hours, miles flown estimates, estimates of the number of landings, IFR hours flown, and grade of fuel consumed by the general aviation fleet. Aircraft, Aircraft activity, Aircraft use, Fuel consumption, General aviation, Hours flown, Miles flown.

  17. Field Operations Program Activities Status Report

    SciTech Connect

    J. E. Francfort; D. V. O'Hara; L. A. Slezak

    1999-05-01

    The Field Operations Program is an electric vehicle testing and evaluation program sponsored by US Department of Energy and managed by the Idaho National Engineering and Environmental Laboratory. The Program's goals are to evaluate electric vehicles in real-world applications and environments, support electric vehicle technology advancement, develop infrastructure elements necessary to support significant electric vehicle use, support increased use of electric vehicles in federal fleets, and increase overall awareness and acceptance of electric vehicles. This report covers Program activities from fiscal year 1997 through mid-fiscal year 1999. The Field Operations Program succeeded the Site Operator Program, which ended in September 1996. Electric vehicle testing conducted by the Program includes baseline performance testing (EV America testing), accelerated reliability (life-cycle) testing, and fleet testing. The baseline performance parameters include accelerations, braking, range, energy efficiency, and charging time. The Program collects accelerated reliability and fleet operations data on electric vehicles operated by the Program's Qualified Vehicle Testing (QVT) partners. The Program's QVT partners have over 3 million miles of electric vehicle operating experience.

  18. Activity of faropenem tested against Neisseria gonorrhoeae isolates including fluoroquinolone-resistant strains.

    PubMed

    Jones, Ronald N; Critchley, Ian A; Whittington, William L H; Janjic, Nebojsa; Pottumarthy, Sudha

    2005-12-01

    We evaluated the anti-gonococcal potency of faropenem along with 7 comparator reference antimicrobials against a preselected collection of clinical isolates. The 265 isolates were inclusive of 2 subsets: 1) 76 well-characterized resistant phenotypes of gonococcal strains (53 quinolone-resistant strains--31 with documented quinolone resistance-determining region changes from Japan, 15 strains resistant to penicillin and tetracycline, and 8 strains with intermediate susceptibility to penicillin) and 2) 189 recent isolates from clinical specimens in 2004 from 6 states across the United States where quinolone resistance is prevalent. Activity of faropenem was adversely affected by l-cysteine hydrochloride in IsoVitaleX (4-fold increase in [minimal inhibitory concentration] MIC50; 0.06 versus 0.25 microg/mL). The rank order of potency of the antimicrobials for the entire collection was ceftriaxone (MIC90, 0.06 microg/mL) > faropenem (0.25 microg/mL) > azithromycin (0.5 microg/mL) > cefuroxime (1 microg/mL) > tetracycline (2 microg/mL) > penicillin = ciprofloxacin = levofloxacin (4 microg/mL). Using MIC90 for comparison, faropenem was 4-fold more potent than cefuroxime (0.25 versus 1 microg/mL), but was 4-fold less active than ceftriaxone (0.25 versus 0.06 microg/mL). Although the activity of faropenem was not affected by either penicillinase production (MIC90, 0.12 microg/mL, penicillinase-positive) or increasing ciprofloxacin MIC (0.25 microg/mL, ciprofloxacin-resistant), increasing penicillin MIC was associated with an increase in MIC90 values (0.016 microg/mL for penicillin-susceptible to 0.25 microg/mL for penicillin-resistant strains). Among the recent (2004) clinical gonococcal isolates tested, reduced susceptibility to penicillins, tetracycline, and fluoroquinolones was high (28.0-94.2%). Geographic distribution of the endemic resistance rates of gonococci varied considerably, with 16.7-66.7% of the gonococcal isolates being ciprofloxacin-resistant in Oregon

  19. A Methodology for Post Operational Clean Out of a Highly Active Facility Including Solids Behaviour - 12386

    SciTech Connect

    Edmondson, Michael J.; Ward, Tracy R.; Maxwell, Lisa J.

    2012-07-01

    The Highly Active Liquor Evaporation and Storage (HALES) plant at Sellafield handles acidic fission product containing liquor with typical activities of the order of 18x10{sup 9} Bq/ml. A strategy experimental feedback approach has been used to establish a wash regime for the Post Operational Clean Out (POCO) of the oldest storage tanks for this liquor. Two different wash reagents have been identified as being potentially suitable for removal of acid insoluble fission product precipitates. Ammonium carbamate and sodium carbonate yield similar products during the proposed wash cycle. The proposed wash reagents provide dissolution of caesium phosphomolybdate (CPM) and zirconium molybdate (ZM) solid phases but yields a fine, mobile precipitate of metal carbonates from the Highly Active Liquor (HAL) supernate. Addition of nitric acid to the wash effluent can cause CPM to precipitate where there is sufficient caesium and phosphorous available. Where they are not present (from ZM dissolution) the nitric acid addition initially produces a nitrate precipitate which then re-dissolves, along with the metal carbonates, to give a solid-free solution. The different behaviour of the two solids during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing the rheology of ZM sediments through doping with tellurium or particular organic acids. Two different wash reagents have been identified as being potentially suitable for the POCO of HALES Oldside HASTs. AC and SC both yield similar products during the proposed wash cycle. However, the different behaviour of the two principle HAL solids, CPM and ZM, during the wash cycle has led to the proposal for an amended flowsheet. Additional studies on the potential to change the morphology of crystallising ZM have presented opportunities for changing its rheology through doping with tellurium or certain

  20. CONSENSUS REPORT: Recognizing non-melanoma skin cancer, including actinic keratosis, as an occupational disease - A Call to Action.

    PubMed

    John, S M; Trakatelli, M; Gehring, R; Finlay, K; Fionda, C; Wittlich, M; Augustin, M; Hilpert, G; Barroso Dias, J M; Ulrich, C; Pellacani, G

    2016-04-01

    1. Non-melanoma skin cancer (NMSC) is by far the most common cancer diagnosed in westernized countries, and one of the few almost preventable cancers if detected and treated early as up to 90% of NMSC may be attributed to excessive exposure to ultraviolet radiation. 2. The incidence of NMSC is increasing: 2-3 million people are diagnosed worldwide annually, with an average yearly increase of 3-8% among white populations in Australia, Europe, the US and Canada over the last 30 years. 3. The link between solar ultraviolet (UV) radiation and certain forms of NMSC is clearly recognized. It is estimated that outdoor workers are exposed to an UV radiation dose 2-3 times higher than indoor workers, and there is a growing body of research linking UV radiation exposure in outdoor workers to NMSC: I. Occupationally UV-exposed workers are at least at a 43% higher risk of basal cell carcinoma (BCC) and almost doubled risk of squamous cell carcinoma (SCC) compared to the average population, with risk increasing with decreasing latitude. II. The risk for BCC, SCC and actinic keratosis (AK) among workers who have worked outdoors for more than 5 years is 3-fold higher than the risk among those with no years of working outdoors. 4. Primary prevention, early detection, treatment and regular follow-up of skin cancer (NMSC and melanoma) are shown to be beneficial from a health economic perspective. 5. Action is needed at international, European and national level to legislate for recognizing AK and NMSC as an occupational disease, which has the potential to improve access to compensation and drive preventative activities. 6. This report is a Call to Action for: I. The engagement of key stakeholders, including supranational institutions, national governments, trade organizations, employers, workers and patient organizations to drive change in prevention and protection of at-risk groups. II. Employers should be obliged to prevent outdoor worker's UV exposure from exceeding limit values

  1. CONSENSUS REPORT: Recognizing non-melanoma skin cancer, including actinic keratosis, as an occupational disease - A Call to Action.

    PubMed

    John, S M; Trakatelli, M; Gehring, R; Finlay, K; Fionda, C; Wittlich, M; Augustin, M; Hilpert, G; Barroso Dias, J M; Ulrich, C; Pellacani, G

    2016-04-01

    1. Non-melanoma skin cancer (NMSC) is by far the most common cancer diagnosed in westernized countries, and one of the few almost preventable cancers if detected and treated early as up to 90% of NMSC may be attributed to excessive exposure to ultraviolet radiation. 2. The incidence of NMSC is increasing: 2-3 million people are diagnosed worldwide annually, with an average yearly increase of 3-8% among white populations in Australia, Europe, the US and Canada over the last 30 years. 3. The link between solar ultraviolet (UV) radiation and certain forms of NMSC is clearly recognized. It is estimated that outdoor workers are exposed to an UV radiation dose 2-3 times higher than indoor workers, and there is a growing body of research linking UV radiation exposure in outdoor workers to NMSC: I. Occupationally UV-exposed workers are at least at a 43% higher risk of basal cell carcinoma (BCC) and almost doubled risk of squamous cell carcinoma (SCC) compared to the average population, with risk increasing with decreasing latitude. II. The risk for BCC, SCC and actinic keratosis (AK) among workers who have worked outdoors for more than 5 years is 3-fold higher than the risk among those with no years of working outdoors. 4. Primary prevention, early detection, treatment and regular follow-up of skin cancer (NMSC and melanoma) are shown to be beneficial from a health economic perspective. 5. Action is needed at international, European and national level to legislate for recognizing AK and NMSC as an occupational disease, which has the potential to improve access to compensation and drive preventative activities. 6. This report is a Call to Action for: I. The engagement of key stakeholders, including supranational institutions, national governments, trade organizations, employers, workers and patient organizations to drive change in prevention and protection of at-risk groups. II. Employers should be obliged to prevent outdoor worker's UV exposure from exceeding limit values

  2. Nuclear Rocket Test Facility Decommissioning Including Controlled Explosive Demolition of a Neutron-Activated Shield Wall

    SciTech Connect

    Michael Kruzic

    2007-09-01

    Located in Area 25 of the Nevada Test Site, the Test Cell A Facility was used in the 1960s for the testing of nuclear rocket engines, as part of the Nuclear Rocket Development Program. The facility was decontaminated and decommissioned (D&D) in 2005 using the Streamlined Approach For Environmental Restoration (SAFER) process, under the Federal Facilities Agreement and Consent Order (FFACO). Utilities and process piping were verified void of contents, hazardous materials were removed, concrete with removable contamination decontaminated, large sections mechanically demolished, and the remaining five-foot, five-inch thick radiologically-activated reinforced concrete shield wall demolished using open-air controlled explosive demolition (CED). CED of the shield wall was closely monitored and resulted in no radiological exposure or atmospheric release.

  3. LIPID PEROXIDATION GENERATES BIOLOGICALLY ACTIVE PHOSPHOLIPIDS INCLUDING OXIDATIVELY N-MODIFIED PHOSPHOLIPIDS

    PubMed Central

    Davies, Sean S.; Guo, Lilu

    2014-01-01

    Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease. PMID:24704586

  4. Design of a high-lift experiment in water including active flow control

    NASA Astrophysics Data System (ADS)

    Beutel, T.; Sattler, S.; El Sayed, Y.; Schwerter, M.; Zander, M.; Büttgenbach, S.; Leester-Schädel, M.; Radespiel, R.; Sinapius, M.; Wierach, P.

    2014-07-01

    This paper describes the structural design of an active flow-control experiment. The aim of the experiment is to investigate the increase in efficiency of an internally blown Coanda flap using unsteady blowing. The system uses tailor-made microelectromechanical (MEMS) pressure sensors to determine the state of the oncoming flow and an actuated lip to regulate the mass flow and velocity of a stream near a wall over the internally blown flap. Sensors and actuators are integrated into a highly loaded system that is extremely compact. The sensors are connected to a bus system that feeds the data into a real-time control system. The piezoelectric actuators using the d 33 effect at a comparable low voltage of 120 V are integrated into a lip that controls the blowout slot height. The system is designed for closed-loop control that efficiently avoids flow separation on the Coanda flap. The setup is designed for water-tunnel experiments in order to reduce the free-stream velocity and the system’s control frequency by a factor of 10 compared with that in air. This paper outlines the function and verification of the system’s main components and their development.

  5. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase

    PubMed Central

    Sahonero-Canavesi, Diana X.; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M.; Geiger, Otto

    2016-01-01

    Summary Phospholipids are well known for their membrane forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth. PMID:25711932

  6. Fatty acid-releasing activities in Sinorhizobium meliloti include unusual diacylglycerol lipase.

    PubMed

    Sahonero-Canavesi, Diana X; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M; Geiger, Otto

    2015-09-01

    Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth.

  7. Modeling the development of biofilm density including active bacteria, inert biomass, and extracellular polymeric substances.

    PubMed

    Laspidou, Chrysi S; Rittmann, Bruce E

    2004-01-01

    We present the unified multi-component cellular automaton (UMCCA) model, which predicts quantitatively the development of the biofilm's composite density for three biofilm components: active bacteria, inert or dead biomass, and extracellular polymeric substances. The model also describes the concentrations of three soluble organic components (soluble substrate and two types of soluble microbial products) and oxygen. The UMCCA model is a hybrid discrete-differential mathematical model and introduces the novel feature of biofilm consolidation. Our hypothesis is that the fluid over the biofilm creates pressures and vibrations that cause the biofilm to consolidate, or pack itself to a higher density over time. Each biofilm compartment in the model output consolidates to a different degree that depends on the age of its biomass. The UMCCA model also adds a cellular automaton algorithm that identifies the path of least resistance and directly moves excess biomass along that path, thereby ensuring that the excess biomass is distributed efficiently. A companion paper illustrates the trends that the UMCCA model is able to represent and shows a comparison with experimental results. PMID:15276752

  8. Ozone control of biological activity during Earth's history, including the KT catastrophe

    NASA Technical Reports Server (NTRS)

    Sheldon, W. R.

    1994-01-01

    There have been brief periods since the beginning of the Cambrian some 600 m.y. ago when mass extinctions destroyed a significant fraction of living species. The most widely studied of these events is the catastrophe at the KT boundary that ended the long dominance of the dinosaurs. In addition to mass extinctions, there is another profound discontinuity in the history of Earth's biota, the explosion of life at the end of the Precambrian era which is an episode that is not explained well at all. For some 3 b.y. before the Cambrian, life had been present on Earth, but maintained a low level of activity which is an aspect of the biota that is puzzling, especially during the last two-thirds of that period. During the last 2 b.y. before the Cambrian, conditions at the Earth's surface were suitable for a burgeoning of the biota, according to most criteria: the oceans neither boiled nor were fozen solid during this time, and the atmosphere contained sufficient O for the development of animals. The purpose of this paper is to suggest that mass extinctions and the lackluster behavior of the Precambrian biota share a common cause: an inadequate amount of ozone in the atmosphere.

  9. Radio Properties of Low Redshift Broad Line Active Galactic Nuclei Including Multiple Component Radio Sources

    NASA Astrophysics Data System (ADS)

    Rafter, Stephen E.

    2010-01-01

    We present results on the radio properties of a low redshift (z < 0.35) sample of 8434 broad line active galactic nuclei (AGNs) from the Sloan Digital Sky Survey after correlating the optical sources with radio sources in the Faint Images of the Radio Sky at Twenty-Centimeters survey. We find that 10% of our sample has radio emission < 4" away from the optical counterpart (core-only sources), and 1% has significant extended emission that must be taken into account when calculating the total radio luminosity (multi-component sources). Association of the extended radio emission is established by the proximity to the optical source, physical connection of jets and lobes, or large scale symmetry like in classic FRIIs. From these data we find an FRI/FRII luminosity dividing line like that found by Fanaroff & Riley (1974), where we use our core-only sources as proxies for FRIs, and our multi-component sources for the FRIIs. We find a bimodal distribution for the radio loudness (R = L(radio)/L(opt)) where the lower radio luminosity core-only sources appear as a population separate from the multi-component extended sources, compared with no evidence for bimodality when just the core-only sources are used. We also find that a log(R) value of 1.75 is well suited to separate the FRIs from the FRIIs, and that the R bimodality seen here is really a manifestation of the FRI/FRII break originally found by Fanaroff & Riley (1974). We find modest trends in the radio loud fraction as a function of Eddington ratio and black hole mass, where the fraction of RL AGNs decreases with increasing Eddington ratio, and increases when the black hole mass is above 2 x 108 solar masses.

  10. 77 FR 1073 - Privacy Act of 1974; Report of an Altered System of Records, Including Addition of Routine Uses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... HUMAN SERVICES Food and Drug Administration Privacy Act of 1974; Report of an Altered System of Records, Including Addition of Routine Uses to an Existing System of Records; Bioresearch Monitoring Information System AGENCY: Food and Drug Administration, HHS. ACTION: Notice of an altered system of records....

  11. Development of an oregano-based ointment with anti-microbial activity including activity against methicillin-resistant Staphlococcus aureus.

    PubMed

    Eng, William; Norman, Robert

    2010-04-01

    Increasing antibiotic resistance has prompted a search for new compounds with anti-microbial activity. In the authors' previous study, oregano extract was identified as one of the most potent anti-microbial compounds. The disk diffusion method was employed to assess the degree of inhibition against various microorganisms, and the bacteriostatic or bactericidal mechanism of action. Disk diffusion studies showed that oregano was found to be bacteriostatic for Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus, (MRSA) but bacteriocidal for seven other microorganisms. Pseudomonas aeruginosa could not be inhibited by oregano. An ointment consisting of 1-10% oregano could inhibit most organisms except for Proteus mirabilis and Proteus vulgaris, which required 20% and Pseudomonas which could not be inhibited even at the highest concentration of 80%. Oregano extracts can be formulated into an ointment that shows broad antimicrobial activity. Additional testing to assess tissue toxicity and other adverse reactions would be needed prior to human testing.

  12. Annual waste reduction activities report. Issue 1

    SciTech Connect

    1991-03-18

    This report discusses the waste minimization activities for the Pinellas Plant. The Pinellas Plant deals with low-level radioactive wastes, solvents, scrap metals and various other hazardous materials. This program has realized cost savings through recycling and reuse of materials.

  13. Physics Division activities report, 1986--1987

    SciTech Connect

    Not Available

    1987-01-01

    This report summarizes the research activities of the Physics Division for the years 1986 and 1987. Areas of research discussed in this paper are: research on e/sup +/e/sup /minus// interactions; research on p/bar p/ interactions; experiment at TRIUMF; double beta decay; high energy astrophysics; interdisciplinary research; and advanced technology development and the SSC.

  14. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Vette, J. I. (Editor); Vostreys, R. W. (Editor)

    1977-01-01

    Information concerning active and planned spacecraft and experiments is reported. The information includes a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and funding of individual countries as well as cooperative arrangements among different countries.

  15. Section on Cataloguing: Report of the Activities, 2000-2001.

    ERIC Educational Resources Information Center

    Witt, Maria

    This paper reports on the activities of the IFLA (International Federation of Library Associations and Institutions) Section on Cataloging for 2000-2001. The first part discusses the interest in cataloging and its harmonization at the international level that is shared by libraries throughout the world, including the section's work on development…

  16. 17p13.3 microduplication including CRK leads to overgrowth and elevated growth factors: A case report.

    PubMed

    Henry, Rohan K; Astbury, Caroline; Stratakis, Constantine A; Hickey, Scott E

    2016-10-01

    17p13.3 microduplications classified as class I duplications involving YWHAE but not PAFAH1B1 (formerly LIS1) and class II duplications which extend to involve PAFAH1B1, are associated with diverse phenotypes including intellectual disability and structural brain malformations. We report a girl with an approximately 1.58 Mb apparently terminal gain of 17p13.3, which contains more than 20 genes including the YWHAE and CRK genes (OMIM: 164762). She had increased growth factors accompanied by pathologic tall stature. In addition to these, she developed central precocious puberty at 7 years old. In individuals with class I 17p13.3 microduplications including CRK, we recommend biochemical evaluation of the growth hormone axis. Providers caring for these patients should be aware of their possible risk for the development of central precocious puberty. PMID:27633569

  17. Internet Reporting of Weekly Physical Activity Behaviors: The WIN Study

    PubMed Central

    Bain, Tyson; Frierson, Georita M.; Trudelle-Jackson, Elaine; Morrow, James R.

    2009-01-01

    Background Self-report measures have been validated and are widely used. Interest currently lies in the development of simple, valid methods that can be used in any location to determine level of PA in large populations/samples. The purpose of this report is to illustrate tracking of physical activity behaviors and musculoskeletal injury reports on a weekly basis via the Internet. Methods The Women’s Injury Study (WIN) methodology includes use of BRFSS-related physical activity items that are completed online by more than 800 women weekly for an average of 3 years. Results With more than 45,000 weekly physical activity and injury logs, the percentage of total logs submitted via online records is 91%. Self-reported pedometer steps are consistent with similar, smaller research samples. Conclusions This report suggests that Internet tracking is a viable means of assessing nearly real-time physical activity, describes the process of developing and monitoring self-reported physical activity behaviors via the Internet, and provides recommendations for others considering such methods. PMID:20683095

  18. Effects of Leisure Education Programme Including Sportive Activities on Perceived Freedom in Leisure of Adolescents with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Ertuzun, Ezgi

    2015-01-01

    The objective of this experimental study is to determine the effect of leisure education programme including sportive activities on the perceived freedom in leisure of adolescents with mild intellectual disabilities. The research was designed with an experimental group (n = 37) and a control group (n = 34), and was conducted among a total of 71…

  19. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  20. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  1. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  2. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  3. 25 CFR 170.623 - How are IRR Program projects and activities included in a self-governance agreement?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... other information required under 25 CFR 1000 subpart K. ... self-governance agreement? 170.623 Section 170.623 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... self-governance agreement? To include an IRR Program project or activity in a self-governance...

  4. Effects of restricted feeding on daily fluctuations of hepatic functions including p450 monooxygenase activities in rats.

    PubMed

    Hirao, Jun; Arakawa, Shingo; Watanabe, Kyoko; Ito, Kazumi; Furukawa, Tadashi

    2006-02-10

    Hepatic P450 monooxygenase activities, assessed by measurement of 7-alkoxycoumarin O-dealkylase (ACD) activities, show obvious daily fluctuations in male rats with high values during the dark period and low values during the light period. We have already confirmed that the ACD activities are controlled by the suprachiasmatic nucleus (SCN), which is well known as the oscillator of circadian rhythm. Recently, it is reported that circadian oscillators exist not only in the SCN but also in peripheral organs. To date, it is unclear which circadian oscillators predominantly drive the daily fluctuations of hepatic ACD activities. To address this question, we examined the effects of restricted feeding, which uncouples the circadian oscillators in the liver from the central pacemaker in the SCN, on the daily fluctuations in hepatic ACD activities in male rats. Here we show that restricted feeding inverts the oscillation phase of the daily fluctuations in hepatic ACD activities. Regarding the hepatic P450 content, there were no fluctuations between the light and dark periods under ad libitum and restricted feeding conditions. Therefore, it is considered that the daily fluctuations in hepatic ACD activities are predominantly driven by the circadian factors in peripheral organs rather than by the oscillator in the SCN directly.

  5. A lipid chemotactic factor from anaerobic coryneform bacteria including Corynebacterium parvum with activity for macrophages and monocytes.

    PubMed Central

    Russell, R J; McInroy, R J; Wilkinson, P C; White, R G

    1976-01-01

    A lipid with chemoattractant (chemotactic) activity for mouse and guinea-pig macrophages and for human blood monocytes is released by anaerobic coryneform bacteria (including Corynebacterium parvum). The active lipid is associated with fibrillar structures which lie on the outside of the bacterial cell and are released spontaneously during growth. The lipid can also be extracted easily by a number of methods. The fibrils are loosely associated with a capsule-like structure composed largely of polysaccharide. Purification of the active lipid was achieved by chloroform-methanol extraction of the whole organisms yielding a chloroform-soluble fraction attracting mononuclear phagocytes at concentrations around 10 microgram/ml. The infra-red spectrum of this material showed lipid but no peptide or sugar. Thin-layer chromatography yielded twelve spots of which three had chemoattractant properties. The most active of these gave staining reactions consistent with the presence of phospholipid, the other two probably contained free fatty acids and triglycerides. Thin-layer electrophoresis also yielded an active phosphorus-containing spot. Saturated fatty acids of chain lengths found in the anaerobic coryne forms had weak monocyte-attractant activity. As the active material was progressively purified, its activity as a monocyte attractant weakened. Images Figure 2 Figure 3 Figure 4 PMID:1027716

  6. 12 CFR 21.11 - Suspicious Activity Report.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Suspicious Activity Report. 21.11 Section 21.11... PROCEDURES, REPORTS OF SUSPICIOUS ACTIVITIES, AND BANK SECRECY ACT COMPLIANCE PROGRAM Reports of Suspicious Activities § 21.11 Suspicious Activity Report. (a) Purpose and scope. This section ensures that...

  7. 12 CFR 21.11 - Suspicious Activity Report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Suspicious Activity Report. 21.11 Section 21.11... PROCEDURES, REPORTS OF SUSPICIOUS ACTIVITIES, AND BANK SECRECY ACT COMPLIANCE PROGRAM Reports of Suspicious Activities § 21.11 Suspicious Activity Report. (a) Purpose and scope. This section ensures that...

  8. 12 CFR 21.11 - Suspicious Activity Report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Suspicious Activity Report. 21.11 Section 21.11... PROCEDURES, REPORTS OF SUSPICIOUS ACTIVITIES, AND BANK SECRECY ACT COMPLIANCE PROGRAM Reports of Suspicious Activities § 21.11 Suspicious Activity Report. (a) Purpose and scope. This section ensures that...

  9. Children's active play: self-reported motivators, barriers and facilitators

    PubMed Central

    2011-01-01

    Background Physical activity has important benefits for children's physical health and mental wellbeing, but many children do not meet recommended levels. Research suggests that active play has the potential to make a valuable contribution to children's overall physical activity, whilst providing additional cognitive, social and emotional benefits. However, relatively little is known about the determinants of UK children's active play. Understanding these factors provides the critical first step in developing interventions to increase children's active play, and therefore overall physical activity. Methods Eleven focus groups were conducted with 77, 10-11 year old children from four primary schools in Bristol, UK. Focus groups examined: (i) factors which motivate children to take part in active play; (ii) factors which limit children's active play and (iii) factors which facilitate children's active play. All focus groups were audio-taped and transcribed verbatim. Data were analysed using a thematic approach. Results Children were motivated to engage in active play because they perceived it to be enjoyable, to prevent boredom, to have physical and mental health benefits and to provide freedom from adult control, rules and structure. However, children's active play was constrained by a number of factors, including rainy weather and fear of groups of teenagers in their play spaces. Some features of the physical environment facilitated children's active play, including the presence of green spaces and cul-de-sacs in the neighbourhood. Additionally, children's use of mobile phones when playing away from home was reported to help to alleviate parents' safety fears, and therefore assist children's active play. Conclusions Children express a range of motivational and environmental factors that constrain and facilitate their active play. Consideration of these factors should improve effectiveness of interventions designed to increase active play. PMID:21663605

  10. Multimodal electrophysiological studies including motor evoked potentials in patients with locked-in syndrome: report of six patients.

    PubMed Central

    Bassetti, C; Mathis, J; Hess, C W

    1994-01-01

    Clinical and electrophysiological findings in six patients with locked-in syndrome are reported. Motor evoked potentials (MEPs) after magnetic stimulation of the motor cortex were absent in four patients, none of whom recovered clinically. In two patients, MEPs could be obtained from the severely paretic limbs and almost full motor recovery followed. Somatosensory evoked potentials were altered in four of the patients, and brainstem auditory evoked potentials were altered in two of four patients examined, showing a clinically unsuspected tegmental involvement. The EEG showed a predominance of reactive alpha activity in all patients, documenting a preserved consciousness. It is concluded that a multimodal electrophysiological approach, in addition to clinical assessment, can be helpful in diagnosing locked-in syndrome, estimating the extension of the underlying brainstem dysfunction, and predicting functional outcome. Images PMID:7964820

  11. Advanced light source. Activity report 1995

    SciTech Connect

    1996-07-01

    The ALS Activity Report is designed to share the breadth, variety, and interest of the scientific program and ongoing R&D efforts in a form that is accessible to a broad audience. Recent research results are presented in six sections, each representing an important theme in ALS science. These results are designed to demonstrate the capabilities of the ALS, rather than to give a comprehensive review of 1995 experiments. Although the scientific program and facilities report are separate sections, in practice the achievements and accomplishments of users and ALS staff are interdependent. This user-staff collaboration is essential to help us direct our efforts toward meeting the needs of the user community, and to ensure the continued success of the ALS as a premier facility.

  12. Endodontic Management of Maxillary First Molar with Five Root Canals, Including Two Distobuccal Root Canals: A Case Report.

    PubMed

    Sinha, Dakshita Joy; Sinha, Ashish Amit; Prakash, Prem; Jaiswal, Natasha

    2016-01-01

    Multiple canals in the root are part of the normal morphology of the tooth. A canal may sometimes be overlooked, however, and this may lead to failure of treatment. The first step in successful endodontic treatment, therefore, is gaining access to the pulp chamber and locating all the canals. In order to achieve this goal, practitioners need to be familiar with all possible variations in root canal morphology, and should thoroughly explore roots to ensure that all canals are identified, debrided, and obturated. Here, we report the diagnosis, treatment planning, and endodontic management of a maxillary first molar with five root canals, including two distobuccal root canals, in a 22-year-old woman. PMID:26961335

  13. Autoimmunity Including Intestinal Behçet Disease Bearing the KRAS Mutation in Lymphocytes: A Case Report.

    PubMed

    Moritake, Hiroshi; Takagi, Masatoshi; Kinoshita, Mariko; Ohara, Osamu; Yamamoto, Shojiro; Moriguchi, Sayaka; Nunoi, Hiroyuki

    2016-03-01

    We experienced the case of a 3-year-old male with a very rare combination of autoimmunity, including immune thrombocytopenia, recurrent Henoch-Schönlein purpura and intestinal Behçet disease. Exome sequencing of the patient's peripheral blood mononuclear cells identified a KRAS G13C mutation. Interestingly, the KRAS G13C mutation was observed in T and B lymphocytes, as well as natural killer cells, but not granulocytes. Our case was completely phenotypically different from RASopathies and did not meet the criteria for Ras-associated lymphoproliferative disease or juvenile myelomonocytic leukemia. This is the first reported case in which the KRAS mutation existed only in the lymphoid lineage. Based on the findings of our case and the current literature, it is clear that the RAS mutation in lymphoid cells is tightly linked with various autoimmune symptoms. The presence of the RAS mutation in lymphocytes should be reconsidered as a pathogenesis in cases of autoimmunity.

  14. [Productivity of doctoral programs in Psychology with Quality Mention in journal articles included in Journal Citation Reports].

    PubMed

    Musi-Lechuga, Bertha; Olivas-Ávila, José; Castro, Angel

    2011-08-01

    The main objective of the present study was to classify doctoral programs with Quality Mention in Psychology based on their scientific productivity. For this purpose, articles in the Web of Science published by professors teaching in these doctoral programs were analyzed. In addition, we analyzed scientific journals in which these professors tend to publish more papers and the evolution in the number of papers published until 2009. Results showed that the most productive doctoral program was the Neurosciences program at the University of Oviedo. This program showed a ratio of 40 articles--published in journals included in Journal Citation Reports--by each professor. In contrast, other programs did not reach a ratio of 10 articles per professor. Regarding journals, results showed that 9 out of the 20 most popular journals are Hispanic and a gradual increase in the number of published papers was also observed. Lastly, results and implications for quality assessment are discussed.

  15. Chelonitoxism in Andaman and Nicobar Island: A report on mass poisoning including a death of an adult.

    PubMed

    Singh, S S; Biswas, Ashok Kumar; Shirley, P; Vijayachari, Paluru

    2016-08-01

    Chelonitoxism is a type of seafood poisoning which usually occurs due to consumption of certain marine turtle flesh. As the pharmacology or chemistry of the toxin is still unknown, antidote or treatment to chelonitoxism is unavailable. The symptoms can vary from common gastro-intestinal symptoms to neurological manifestations and even death. This case report of community poisoning following consumption of turtle meat includes the death of an adult male (56 yrs.) being reported for the first time in the Great Nicobar Island, Andaman and Nicobar (A&N) Islands, India in August 2012. The patient encountered common gastrointestinal symptoms after one day of ingestion of green turtle flesh and later, he developed neurological symptoms and did not respond to symptomatic treatment and expired after four days after the consumption. However, out of 30 villagers who took the same food, six others developed symptoms and recovered within a period of 3-7 days while two pets (a dog and a cat) died within 24 hours as they were fed with the same food. In spite of several existing wildlife protection acts, catching a turtle and making them a source of food-celebration is quite common in coastal areas of the Indian Ocean and the Bay of Bengal which includes A&N Islands. A proper monitoring and follow-up of the food-borne diseases along with a wide range of explorative health education protocol should be implemented especially for the people who are not reachable via media to avoid such incidents in future. PMID:27103071

  16. Intraoral Perineurioma, Soft Tissue Type: Report of Five Cases, Including 3 Intraosseous Examples, and Review of the Literature

    PubMed Central

    Scheithauer, Bernd W.; Folpe, Andrew L.

    2010-01-01

    Soft tissue type perineuriomas (STP) are uncommon tumors, oral examples being very rare. They have been described in the mandible, gingiva, lips, retrotonsillar mucosa and maxillary vestibule. Herein, we report the clinicopathologic features of five STP, two affecting the buccal mucosa and three the mandible. Three patients were women and two men. All tumors were characterized by a proliferation of cytologically bland, mitotically inactive spindled cells with round, ovoid or spindled nuclei, embedded in a variably collagenous and myxoid matrix. Interestingly, two mandibular tumors featured psammoma bodies and one, in addition, contained irregular calcifications. Tumor cells showed the immunohistochemical profile of perineurial cells including epithelial membrane antigen, Glut-1, claudin-1 and collagen type IV. S100 and neurofilament proteins were not expressed by the tumor cells. A few minute, peripherally situated, entrapped nerves were identified. All tumors were reported gross-totally excised and no recurrences have taken place. The clinical characteristics of STP are summarized and its differential diagnosis relative to other spindle cells tumors and meningioma is discussed. PMID:20401642

  17. Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City.

    PubMed

    Abdallah, Marie; Olafisoye, Olawole; Cortes, Christopher; Urban, Carl; Landman, David; Quale, John

    2015-03-01

    Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene. PMID:25534744

  18. Forty-Fourth Annual Report of the National Advisory Committee for Aeronautics Administrative Report Including Technical Reports Nos. 1342 to 1392

    NASA Technical Reports Server (NTRS)

    1959-01-01

    In accordance with act of Congress, approved March 3, 1915, as amended (U.S.C., title 50, .sw 151), which established the National Advisory Committee for Aeronautics, the Committee submits its Forty-fourth Annual Report for the fiscal year 1958. This is the Committee's final report to the Congress. The National Aeronautics and Space Act of 1958 (Public Law 85-568) provides in section 301 that the NACA "shall cease to exist" and "all functions, powers, duties, and obligations, and all real and personal property, personnel (other than members of the Committee), funds, and records of the NACA shall be transferred to the National Aeronautics and Space Administration. The aforesaid act provides that "this section shall take effect 90 days after the date of the enactment of this act, or on any earlier date on which the Administrator shall determining and announce by proclamation published in the Federal Register, that the Administration has been organized and is prepared to discharge the duties and exercise the power conferred upon it by this act." The Administrator, Hon. T. Keith Glennan has advised the Committee of his intention to issue such proclamation, effective October 1,1958.

  19. Frio II Brine Pilot: Report on GEOSEQ Activities

    SciTech Connect

    Daley, T.M.; Freifeld, B.M.; Ajo-Franklin, J.B.; Doughty, C.; Benson, S.M.

    2007-11-17

    LBNL's GEOSEQ project is a key participant in the Frio IIbrine pilot studying geologic sequestration of CO2. During During theinjection phase of the Frio-II brine pilot, LBNL collected multiple datasets including seismic monitoring, hydrologic monitoring and geochemicalsampling. These data sets are summarized in this report including allCASSM (continuous active source seismic monitoring) travel time data,injection pressure and flow rate data and gaseous sampling and tracerdata. Additional results from aqueous chemistry analysis performed by theU. S. Geological Survey (USGS) are summarized. Post injectionmodification of the flow model for Frio II is shown. Thesemodificationsare intended to facilitate integration with the monitoring data andincorporation of model heterogeneity. Current activities of LBNL's GEOSEQproject related to the Frio II test are shown, including development of anew petrophysical model for improved interpretation of seismic monitoringdata and integration of this data with flow modeling.

  20. The NLP toxin family in Phytophthora sojae includes rapidly evolving groups that lack necrosis-inducing activity.

    PubMed

    Dong, Suomeng; Kong, Guanghui; Qutob, Dinah; Yu, Xiaoli; Tang, Junli; Kang, Jixiong; Dai, Tingting; Wang, Hai; Gijzen, Mark; Wang, Yuanchao

    2012-07-01

    Necrosis- and ethylene-inducing-like proteins (NLP) are widely distributed in eukaryotic and prokaryotic plant pathogens and are considered to be important virulence factors. We identified, in total, 70 potential Phytophthora sojae NLP genes but 37 were designated as pseudogenes. Sequence alignment of the remaining 33 NLP delineated six groups. Three of these groups include proteins with an intact heptapeptide (Gly-His-Arg-His-Asp-Trp-Glu) motif, which is important for necrosis-inducing activity, whereas the motif is not conserved in the other groups. In total, 19 representative NLP genes were assessed for necrosis-inducing activity by heterologous expression in Nicotiana benthamiana. Surprisingly, only eight genes triggered cell death. The expression of the NLP genes in P. sojae was examined, distinguishing 20 expressed and 13 nonexpressed NLP genes. Real-time reverse-transcriptase polymerase chain reaction results indicate that most NLP are highly expressed during cyst germination and infection stages. Amino acid substitution ratios (Ka/Ks) of 33 NLP sequences from four different P. sojae strains resulted in identification of positive selection sites in a distinct NLP group. Overall, our study indicates that expansion and pseudogenization of the P. sojae NLP family results from an ongoing birth-and-death process, and that varying patterns of expression, necrosis-inducing activity, and positive selection suggest that NLP have diversified in function.

  1. 41 CFR 102-192.90 - What must we include in our annual mail management report to GSA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... annual mail management report to GSA? Your annual report must— (a) Identify your agency mail manager; in addition you must promptly report the name of the agency mail manager whenever there is a change of the... accomplishments and plans to improve the economy and efficiency of mail operations in the current and future...

  2. 41 CFR 102-192.90 - What must we include in our annual mail management report to GSA?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... annual mail management report to GSA? Your annual report must— (a) Identify your agency mail manager; in addition you must promptly report the name of the agency mail manager whenever there is a change of the... accomplishments and plans to improve the economy and efficiency of mail operations in the current and future...

  3. Thirty-Seventh Annual Report of the National Advisory Committee for Aeronautics: Administrative Report Including Technical Report Nos. 1003 to 1958

    NASA Technical Reports Server (NTRS)

    1952-01-01

    In accordance with the act of Congress, approved March 3,1915 (U.S. C. title 50, sec. 151), which established the National Advisory Committee for Aeronautics the Committee submits its thirty-seventh annual report for the fiscal year 1951. The United States is engaged in expanding military aviation to levels never before reached except in the midst of a major war. In Korea, our military aircraft are engaged in combat with airplanes of an unfriendly nation evidently able to build military aircraft of increasing capabilities. In this environment, the NACA is responsible for conducting an adequate program of scientific research to open the way for the design of aircraft and missile of superior performance. Since World War II the pace of technical development has increased. Until then, improvement in aircraft performance as a result of the application of scientific research proceeded at what. now seems to be a relatively slow and orderly rate. Modest increases in speed, climb, range, or altitude were set as reasonable goals. Compressibility effects at high speeds were just beginning to be encountered and indicated a formidable barrier near the velocity of sound. This barrier has been found by research and experiment to be lees formidable than supposed, and we now see the possibility of radical gains in airplane performance that are of great military significance. Such gains are ak attainable by a potential enemy. The increased complexity of modern high performance

  4. 12 CFR 208.62 - Suspicious activity reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Suspicious activity reports. 208.62 Section 208... Requirements § 208.62 Suspicious activity reports. (a) Purpose. This section ensures that a member bank files a Suspicious Activity Report when it detects a known or suspected violation of Federal law, or a...

  5. Needs assessment activity report: April 1995

    SciTech Connect

    1995-04-01

    As part of a US Department of Energy Headquarters task (DOE-HQ), the Packaging Operations and Development Group within Westinghouse Hanford Company (WHC) has assessed the packaging needs of many DOE sites. These assessments have involved site visits and meetings with personnel involved with transportation and packaging of hazardous materials. By March 1995, 20 DOE facilities had been visited. As a result, these sites been informed of some of the packaging activities that DOE has sponsored and is sponsoring, have been apprised of the affects of upcoming changes to transportation regulations, have discussed their short-term packaging needs, and have shared unique packaging they have developed which may be of use to other DOE facilities. Program successes include discovery of a need for a reusable Type A liquid sample packaging and its development within another DOE task, establishing communications pathways between DOE sites that have similar transportation and packaging needs, and starting to establish a centralized packaging clearinghouse that will coordinate DOE Complex needs and improve the cost-effectiveness of transportation and packaging activities.

  6. Issues Relating to Selective Reporting When Including Non-Randomized Studies in Systematic Reviews on the Effects of Healthcare Interventions

    ERIC Educational Resources Information Center

    Norris, Susan L.; Moher, David; Reeves, Barnaby C.; Shea, Beverley; Loke, Yoon; Garner, Sarah; Anderson, Laurie; Tugwell, Peter; Wells, George

    2013-01-01

    Background: Selective outcome and analysis reporting (SOR and SAR) occur when only a subset of outcomes measured and analyzed in a study is fully reported, and are an important source of potential bias. Key methodological issues: We describe what is known about the prevalence and effects of SOR and SAR in both randomized controlled trials (RCTs)…

  7. Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

    PubMed Central

    2015-01-01

    DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of gene expression and represent valuable targets in cancer chemotherapy. A number of nucleoside DNMT inhibitors (DNMTi) have been studied in cancer, including in cancer stem cells, and two of them (azacytidine and decitabine) have been approved for treatment of myelodysplastic syndromes. However, only a few non-nucleoside DNMTi have been identified so far, and even fewer have been validated in cancer. Through a process of hit-to-lead optimization, we report here the discovery of compound 5 as a potent non-nucleoside DNMTi that is also selective toward other AdoMet-dependent protein methyltransferases. Compound 5 was potent at single-digit micromolar concentrations against a panel of cancer cells and was less toxic in peripheral blood mononuclear cells than two other compounds tested. In mouse medulloblastoma stem cells, 5 inhibited cell growth, whereas related compound 2 showed high cell differentiation. To the best of our knowledge, 2 and 5 are the first non-nucleoside DNMTi tested in a cancer stem cell line. PMID:24387159

  8. Aeronautics and space report of the President: 1981 activities

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Achievements in the aeronautics and space program by function are summarized. Activities in communications, Earth's resources and environment, space science, space transportation, international activities, and aeronautics are included.

  9. Low-rank coal research. Final technical report, April 1, 1988--June 30, 1989, including quarterly report, April--June 1989

    SciTech Connect

    Not Available

    1989-12-31

    This work is a compilation of reports on ongoing research at the University of North Dakota. Topics include: Control Technology and Coal Preparation Research (SO{sub x}/NO{sub x} control, waste management), Advanced Research and Technology Development (turbine combustion phenomena, combustion inorganic transformation, coal/char reactivity, liquefaction reactivity of low-rank coals, gasification ash and slag characterization, fine particulate emissions), Combustion Research (fluidized bed combustion, beneficiation of low-rank coals, combustion characterization of low-rank coal fuels, diesel utilization of low-rank coals), Liquefaction Research (low-rank coal direct liquefaction), and Gasification Research (hydrogen production from low-rank coals, advanced wastewater treatment, mild gasification, color and residual COD removal from Synfuel wastewaters, Great Plains Gasification Plant, gasifier optimization).

  10. 42 CFR 137.202 - What types of information will Self-Governance Tribes be expected to include in the reports?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false What types of information will Self-Governance... SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.202 What types of information will Self-Governance Tribes be expected to include in the reports? Reports will be derived from...

  11. 42 CFR 137.202 - What types of information will Self-Governance Tribes be expected to include in the reports?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false What types of information will Self-Governance... SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.202 What types of information will Self-Governance Tribes be expected to include in the reports? Reports will be derived from...

  12. 42 CFR 137.202 - What types of information will Self-Governance Tribes be expected to include in the reports?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false What types of information will Self-Governance... SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.202 What types of information will Self-Governance Tribes be expected to include in the reports? Reports will be derived from...

  13. 42 CFR 137.202 - What types of information will Self-Governance Tribes be expected to include in the reports?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false What types of information will Self-Governance... SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.202 What types of information will Self-Governance Tribes be expected to include in the reports? Reports will be derived from...

  14. 42 CFR 137.202 - What types of information will Self-Governance Tribes be expected to include in the reports?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false What types of information will Self-Governance... SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.202 What types of information will Self-Governance Tribes be expected to include in the reports? Reports will be derived from...

  15. 1990 Activity report for 1986-1992

    SciTech Connect

    Cantwell, K.

    1996-01-01

    As discussed in last year`s Activity Report, a fairly complete analysis of SPEAR problems was performed in concert with SLAC, and a major maintenance/improvement process was initiated in the spring of 1989. This run made it apparent that SPEAR will remain a very useful and impressive synchrotron radiation storage ring for at least a decade, given a steady maintenance and improvement program. More details about SPEAR functioning during the run, as well as SPEAR improvements, are contained in Chapter I. The formal SPEAR injector construction project was completed in November, 1990, on-time and on-budget. Although DOE was not able to provide anticipated FY90 commissioning funds, preliminary commissioning was performed and 2.3 GeV injection to SPEAR was demonstrated. A discussion of the Injector project is contained in Chapter II. Commissioning of the injector and the injector/SPEAR complex is continuing in 1991 with Users participating during the May-September period. This user participation allowed normal experimentation, so that systems could be tested critically, but with the commissioning process having higher priority than data acquisition. Another major event in 1990 was the full dedication of SPEAR to the synchrotron radiation program. Previously SPEAR was considered a high energy physics machine that was partially dedicated to synchrotron radiation. The full dedication means that the accelerator can be modified and improved for synchrotron radiation research. Despite the heavy emphasis on completing the Injector, many beam line improvements were achieved, as described in Chapter IV. Among these was the optimization of stations 6-2 and 10-2, the provision of a considerably larger hutch for Station 1-5, which contains the area detector diffractometer, and the introduction of white light capability on 10-2. The provision of good beam during the month of April made an appreciable amount of experimentation possible. These and other runs are described in Chapter VI.

  16. U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)

    USGS Publications Warehouse

    Tony K. Meunier Edited by Williams, Richard S.; Ferrigno, Jane G.

    2007-01-01

    international) programs in biology, geology, geophysics, hydrology, and mapping. Therefore, the USGS was the obvious choice for these tasks, because it already had a professional staff of experienced mapmakers, scientists, and program managers with the foresight, dedication, and understanding of the need for accurate maps to support the science programs in Antarctica when asked to do so by the U.S. National Academy of Sciences. Public Laws 85-743 and 87-626, signed in August 1958, and in September 1962, respectively, authorized the Secretary, U.S. Department of the Interior, through the USGS, to support mapping and scientific work in Antarctica (Meunier, 1979 [2007], appendix A). Open-File Report 2006-1116 includes scanned facsimiles of postal cachets. It has become an international practice to create postal cachets to commemorate special events and projects in Antarctica. A cachet is defined as a seal or commemorative design printed or stamped on an envelope to mark a philatelic or special event. The inked impression illustrates to the scientist, historian, stamp collector, and general public the multidisciplinary science projects staffed by USGS and collaborating scientists during the field season. Since 1960, philatelic cachets have been created by team members for each USGS field season and, in most cases, these cachets depict the specific geographic areas and field season program objectives. The cachets become a convenient documentation of the people, projects, and geographic places of interest for that year. Because the cachets are representative of USGS activities, each year's cachet is included as a digital facsimile in that year's Open-File Report. In the 1980s, multiple USGS cachets were prepared each year, one for use by the winter team at Amundsen-Scott South Pole Station and the other for the project work areas of the austral summer field season programs.

  17. Statewide Project to Include Aging Content in Colleges of Pharmacy. An Administration on Aging Project. Final Report.

    ERIC Educational Resources Information Center

    Rousch, Robert

    The project described in this report was designed to: (1) address the lack of adequately trained faculty members needed to introduce geriatrics within colleges of pharmacy, (2) facilitate the use of existing materials within the educational program provided pharmacy students, (3) teach a geriatric pharmacy course twice at each of Texas' three…

  18. Hallucinogens and Dissociative Drugs, Including LSD, PCP, Ketamine, Dextromethorphan. National Institute on Drug Abuse Research Report Series.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHHS/PHS), Rockville, MD.

    Research is developing a clearer picture of the dangers of mind-altering drugs. The goal of this report is to present the latest information to providers to help them strengthen their prevention and treatment efforts. A description is presented of dissociative drugs, and consideration is given as to why people take hallucinogens. The physical…

  19. [Evaluation of an obesity prevention intervention which included nutrition education and physical activity applied in public schools of Santiago, Chile].

    PubMed

    Kain, Juliana; Leyton, Bárbara; Concha, Fernando; Weisstaub, Gerardo; Lobos, Luz; Bustos, Nelly; Vio, Fernando

    2012-03-01

    The main objective of this study was to assess the effectiveness of an obesity prevention intervention which included nutrition education and physical activity applied to low income Chilean children in a longitudinal three-year follow-up study. Participants included all 4-7 year old children from 7 public schools located in a low socioeconomic district of Santiago. The main aspects of the intervention were: training of teachers so they could apply an educational program on healthy eating, increase in physical education classes from 3 to 4 per week, and improvement of their quality. Weight, height, waist circumference (WC) and the 6-minute walk distance (6MWD) were assessed yearly in 597 children. We calculated BMI, BMI Z, % normal (N), overweight (OW) and obesity (OB), WC > 90th percentile (NHANES III) and fitness (6MWD/height). Annual changes in BMI Z, WC, 6MWD and fitness were assessed, using repeated measures ANOVA and the test of proportions. Knowledge in healthy eating was assessed during 2 of the 3 years. Results showed that % OB remained unchanged for 2 years (17%) but increased to 19.3% at follow-up. BMI Z increased from 0.3 to 0.38 (p = 0.052) in the N, remained unchanged in the OW, while decreasing significantly in the OB (2.73 to 2.41 p < 0.0001). % WC > 90 th percentile decreased in the OW and OB; 6 MWD was higher in the OW, but the increase in distance overtime was greater among the N. Overall fitness improved, however it was only significant among the N (p = 0.0002). There was a significant increase in food knowledge. We conclude that in spite of a decrease in BMI Z of the OB, an improvement in fitness in the N and food knowledge in all the children, obesity increased at follow-up. This study shows that in school-based obesity programs it is necessary to apply more intense interventions with another type of methodology; otherwise this condition will continue to rise.

  20. Treatment of knee arthrofibrosis and quadriceps insufficiency after patellar tendon repair: a case report including use of the graston technique.

    PubMed

    Black, Douglass W

    2010-06-23

    Arthrofibrosis of the knee is a surgical complication that can limit range of motion, inhibit muscle activity, and decrease patient function. Optimal conservative treatment has not been well established in the literature, leaving a clinician with limited evidence for treatment planning. Described here is part of the rehabilitative course of care for a patient with arthrofibrotic limitations after a mid-substance patellar tendon repair with augmentation. Marked limitations in knee flexion range of motion and quadriceps activity were addressed using the Graston Technique to deal with soft-tissue adhesions; traditional physical therapy care was also provided. Clear improvement in range of motion and quadriceps activity and function was noted over the course of 5 treatments during 1 month. Treatment process and clinical reasoning are offered to promote understanding and to facilitate future inquiry.

  1. Treatment of Knee Arthrofibrosis and Quadriceps Insufficiency after Patellar Tendon Repair: A Case Report Including Use of the Graston Technique

    PubMed Central

    Black, Douglass W.

    2010-01-01

    Arthrofibrosis of the knee is a surgical complication that can limit range of motion, inhibit muscle activity, and decrease patient function. Optimal conservative treatment has not been well established in the literature, leaving a clinician with limited evidence for treatment planning. Described here is part of the rehabilitative course of care for a patient with arthrofibrotic limitations after a mid-substance patellar tendon repair with augmentation. Marked limitations in knee flexion range of motion and quadriceps activity were addressed using the Graston Technique to deal with soft-tissue adhesions; traditional physical therapy care was also provided. Clear improvement in range of motion and quadriceps activity and function was noted over the course of 5 treatments during 1 month. Treatment process and clinical reasoning are offered to promote understanding and to facilitate future inquiry. PMID:21589706

  2. 12 CFR 163.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Suspicious Activity Reports and other reports... THE TREASURY SAVINGS ASSOCIATIONS-OPERATIONS Reporting and Bonding § 163.180 Suspicious Activity... deductible amount. (d) Suspicious Activity Reports—(1) Purpose and scope. This paragraph (d) ensures...

  3. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Suspicious Activity Reports and other reports... THE TREASURY SAVINGS ASSOCIATIONS-OPERATIONS Reporting and Bonding § 563.180 Suspicious Activity... deductible amount. (d) Suspicious Activity Reports—(1) Purpose and scope. This paragraph (d) ensures...

  4. 12 CFR 563.180 - Suspicious Activity Reports and other reports and statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Suspicious Activity Reports and other reports... THE TREASURY SAVINGS ASSOCIATIONS-OPERATIONS Reporting and Bonding § 563.180 Suspicious Activity... any covered losses greater than twice the deductible amount. (d) Suspicious Activity...

  5. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity, hydrogen chloride, and... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or... carbon feed rate established during the most recent mercury and dioxins/furans stack test (as...

  6. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity, hydrogen chloride, and... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or... carbon feed rate established during the most recent mercury and dioxins/furans stack test (as...

  7. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity, hydrogen chloride, and... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or... carbon feed rate established during the most recent mercury and dioxins/furans stack test (as...

  8. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity, hydrogen chloride, and... actions. (c) For municipal waste combustion units that apply activated carbon to control dioxins/furans or... carbon feed rate established during the most recent mercury and dioxins/furans stack test (as...

  9. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., and your corrective actions: (1) Concentration or percent reduction of sulfur dioxide emissions. (2...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon...

  10. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., and your corrective actions: (1) Concentration or percent reduction of sulfur dioxide emissions. (2...) Concentration of carbon monoxide emissions. (4) Load level of your municipal waste combustion unit. (5... and your corrective actions. (c) For municipal waste combustion units that apply activated carbon...

  11. National Synchrotron Light Source 2010 Activity Report

    SciTech Connect

    Rowe, M.; Snyder, K. J.

    2010-12-29

    This is a very exciting period for photon sciences at Brookhaven National Laboratory. It is also a time of unprecedented growth for the Photon Sciences Directorate, which operates the National Synchrotron Light Source (NSLS) and is constructing NSLS-II, both funded by the Department of Energy's Office of Science. Reflecting the quick pace of our activities, we chose the theme 'Discovery at Light Speed' for the directorate's 2010 annual report, a fiscal year bookended by October 2009 and September 2010. The year began with the news that NSLS users Venki Ramakrishnan of Cambridge University (also a former employee in Brookhaven's biology department) and Thomas A. Steitz of Yale University were sharing the 2009 Nobel Prize in Chemistry with Ada E. Yonath of the Weizmann Institute of Science. Every research project has the potential for accolades. In 2010, NSLS users and staff published close to 900 papers, with about 170 appearing in premiere journals. Those are impressive stats for a facility nearly three decades old, testament to the highly dedicated team keeping NSLS at peak performance and the high quality of its user community. Our NSLS users come from a worldwide community of scientists using photons, or light, to carry out research in energy and environmental sciences, physics, materials science, chemistry, biology and medicine. All are looking forward to the new capabilities enabled by NSLS-II, which will offer unprecedented resolution at the nanoscale. The new facility will produce x-rays more than 10,000 times brighter than the current NSLS and host a suite of sophisticated instruments for cutting-edge science. Some of the scientific discoveries we anticipate at NSLS-II will lead to major advances in alternative energy technologies, such as hydrogen and solar. These discoveries could pave the way to: (1) catalysts that split water with sunlight for hydrogen production; (2) materials that can reversibly store large quantities of electricity or hydrogen; (3

  12. Self-Reported Health Experiences of Children Living with Congenital Heart Defects: Including Patient-Reported Outcomes in a National Cohort Study

    PubMed Central

    Tadic, Valerija; Hogan, Ailbhe; Bull, Catherine; Rahi, Jugnoo Sangeeta; Dezateux, Carol

    2016-01-01

    Background Understanding children’s views about living with congenital heart defects (CHDs) is fundamental to supporting their successful participation in daily life, school and peer relationships. As an adjunct to a health and quality of life outcomes questionnaire, we asked school-age children who survived infant heart procedures to describe their experiences of living with CHDs. Methods In a UK-wide cohort study, children aged 10 to 14 years with CHDs self-completed postal questionnaires that included an open question about having a ‘heart problem’. We compared the characteristics of children with more and less severe cardiac diagnoses and, through collaborative inductive content analysis, investigated the subjective experiences and coping strategies described by children in both clinical severity groups. Results Text and/or drawings were returned by 436 children (246 boys [56%], mean age 12.1 years [SD 1.0; range 10–14]); 313 had less severe (LS) and 123 more severe (MS) cardiac diagnoses. At the most recent hospital visit, a higher proportion of the MS group were underweight (more than two standard deviations below the mean for age) or cyanosed (underweight: MS 20.0%, LS 9.9%; cyanosed: MS 26.2%, LS 3.5%). Children in the MS group described concerns about social isolation and feeling ‘different’, whereas children with less severe diagnoses often characterised their CHD as ‘not a big thing’. Some coping strategies were common to both severity groups, including managing health information to avoid social exclusion, however only children in the LS group considered their CHD ‘in the past’ or experienced a sense of survivorship. Conclusions Children’s reported experiences were not dependent on their cardiac diagnosis, although there were clear qualitative differences by clinical severity group. Children’s concerns emphasised social participation and our findings imply a need to shift the clinical focus from monitoring cardiac function to

  13. Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge.

    PubMed

    Tara, S; Elcock, A H; Kirchhoff, P D; Briggs, J M; Radic, Z; Taylor, P; McCammon, J A

    1998-12-01

    It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavior of the ligand within the active site gorge of acetylcholinesterase. Negatively charged residues near the gorge opening not only attract positively charged ligands from solution to the enzyme, but can also restrict the motion of the ligand once it is inside of the gorge. We use Brownian dynamics techniques to calculate the rate constant kon, for wild type and mutant acetylcholinesterase with a positively charged ligand. These calculations are performed by allowing the ligand to diffuse within the active site gorge. This is an extension of previously reported work in which a ligand was allowed to diffuse only to the enzyme surface. By setting the reaction criteria for the ligand closer to the active site, better agreement with experimental data is obtained. Although a number of residues influence the movement of the ligand within the gorge, Asp74 is shown to play a particularly important role in this function. Asp74 traps the ligand within the gorge, and in this way helps to ensure a reaction.

  14. TUNL XIX. Annual report, January 1-December 31, 1980. [North Carolina State Univ. activities at TUNL

    SciTech Connect

    1980-12-31

    Research performed by North Carolina State University personnel at TUNL is highlighted in this report, which is actually the complete TUNL progress report for 1980. Studies in the areas of neutron cross sections, neutron polarization, radiative capture, atomic physics and development activities are included. One may expect completed projects to be reported in physics journals or conference proceedings. (RWR)

  15. 40 CFR 60.1425 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... your particulate matter air pollution control device. (6) Average 6-minute opacity level. The data...) Documentation of each quarter when total carbon purchased and delivered to the municipal waste combustion plant... delivered for each individual municipal waste combustion unit at your plant. Include five items: (i)...

  16. 40 CFR 60.1900 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... flue gases at the inlet of your particulate matter air pollution control device. (6) Average 6-minute... delivered to the municipal waste combustion plant is less than the total required quarterly usage of carbon... unit at your plant. Include five items: (i) Amount of carbon purchased and delivered to the plant....

  17. Extension of TVCAI Project to Include Demonstration of Intelligent Videodisc System. Hardware, Software, and Courseware Implementation Component. Final Report.

    ERIC Educational Resources Information Center

    Brandt, Richard C.; Knapp, Barbara H.

    This project, stemming from work started under the National Science Foundation grant "Development of a Television Computer Assisted Instruction (TVCAI) System" SER-7806412, called for the transfer to videodisc of some of the videotape materials developed under the grant. Three efforts were included in the proposal: design and development of…

  18. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... this subpart as applicable for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity... control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8...) is less than the highest carbon feed rate established during the most recent mercury and...

  19. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... this subpart as applicable for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity... control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8...) is less than the highest carbon feed rate established during the most recent mercury and...

  20. 40 CFR 62.15355 - What must I include in the semiannual out-of-compliance reports?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... this subpart as applicable for dioxins/furans, cadmium, lead, mercury, particulate matter, opacity... control dioxins/furans or mercury emissions, include two items: (1) Documentation of all dates when the 8...) is less than the highest carbon feed rate established during the most recent mercury and...

  1. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  2. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  3. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  4. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  5. 25 CFR 170.137 - What types of activities can a recreation, tourism, and trails program include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What types of activities can a recreation, tourism, and... Eligibility Recreation, Tourism and Trails § 170.137 What types of activities can a recreation, tourism, and... may perform under a recreation, tourism, and trails program: (1) Transportation planning for...

  6. HEPS Inventory Tool: An Inventory Tool Including Quality Assessment of School Interventions on Healthy Eating and Physical Activity

    ERIC Educational Resources Information Center

    Dadaczynski, Kevin; Paulus, Peter; de Vries, Nanne; de Ruiter, Silvia; Buijs, Goof

    2010-01-01

    The HEPS Inventory Tool aims to support stakeholders working in school health promotion to promote high quality interventions on healthy eating and physical activity. As a tool it provides a step-by-step approach on how to develop a national or regional inventory of existing school based interventions on healthy eating and physical activity. It…

  7. Advanced Light Source Activity Report 2002

    SciTech Connect

    Duque, Theresa; Greiner, Annette; Moxon, Elizabeth; Robinson, Arthur; Tamura, Lori

    2003-06-12

    This annual report of the Advanced Light Source details science highlights and facility improvements during the year. It also offers information on events sponsored by the facility, technical specifications, and staff and publication information.

  8. NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 1998.

    SciTech Connect

    ROTHMAN,E.

    1999-05-01

    In FY 1998, following the 50th Anniversary Year of Brookhaven National Laboratory, Brookhaven Science Associates became the new Managers of BNL. The new start is an appropriate time to take stock of past achievements and to renew or confirm future goals. During the 1998 NSLS Annual Users Meeting (described in Part 3 of this Activity Report), the DOE Laboratory Operations Board, Chaired by the Under Secretary for Energy, Ernest Moniz met at BNL. By chance all the NSLS Chairmen except Martin Blume (acting NSLS Chair 84-85) were present as recorded in the picture. Under their leadership the NSLS has improved dramatically: (1) The VUV Ring current has increased from 100 mA in October 1982 to nearly 1 A today. For the following few years 10 Ahrs of current were delivered most weeks - NSLS now exceeds that every day. (2) When the first experiments were performed on the X-ray ring during FY1985 the electron energy was 2 GeV and the current up to 100 mA - the X-Ray Ring now runs routinely at 2.5 GeV and at 2.8 GeV with up to 350 mA of current, with a very much longer beam half-life and improved reliability. (3) Starting in FY 1984 the proposal for the Phase II upgrade, mainly for a building extension and a suite of insertion devices and their associated beamlines, was pursued - the promises were delivered in full so that for some years now the NSLS has been running with two undulators in the VUV Ring and three wigglers and an undulator in the X-Ray Ring. In addition two novel insertion devices have been commissioned in the X13 straight. (4) At the start of FY 1998 the NSLS welcomed its 7000th user - attracted by the opportunity for pursuing research with high quality beams, guaranteed not to be interrupted by 'delivery failures', and welcomed by an efficient and caring user office and first class teams of PRT and NSLS staff. R & D have lead to the possibility of running the X-Ray Ring at the higher energy of 2.8 GeV. Figure 1 shows the first user beam, which was provided

  9. Uranium potential of southwestern New Mexico (southern Hidalgo County), including observations on crystallization history of lavas and ash tuffs and the release of uranium from them. Final report

    SciTech Connect

    Walton, A.W.; Salter, T.L.; Zetterlund, D.

    1980-08-01

    Geological environments present in southwestern New Mexico include thick sequences of sedimentary rock including limestone, conglomerates, sandstone, and shale: igneous intrusions with associated metal deposits; caldera centers, margins, and outflow facies; and basins with marginal faults and thick late Cenozoic sedimentary fillings. Predominant rock types are Paleozoic carbonates, Mesozoic terrigeneous rocks and carbonates, and Cenozoic volcanic rocks and basin-filling terrigeneous rocks. Consideration of information available in Preliminary Reconnaissance Reports and in Hydrogeochemical and Stream Reconnaissance Reports together with 347 new whole rock chemical analyses points to three areas of anomalous uranium abundance in Hidalgo County, New Mexico. The area has experienced three major periods of igneous activity in Phanerozoic time: one associated with the Laramide cycle of the Late Cretaceous and early Tertiary, mid-Tertiary cycle of silicic volcanism with abundant calderas, and a late Tertiary cycle of mafic volcanism. Silicic volcanic rocks are the most common exposed rock type in the area, and the most enriched in uranium (range, 0.4 to 19 ppM). The most likely source for any uranium ore-forming solutions lies with this cycle of volcanism. Solutions might have been introduced during volcanism or formed later by groundwater leaching of cooled volcanic rocks. Results indicate that groundwater leaching of cooled volcanic rocks was not an effective means of mobilizing uranium in the area. Study of several rhyolite lava flows indicates that they were emplaced in supercooled condition and may have crystallized completely at temperatures well below their liquids, or they may have warmed as crystallization released latent heat. Statistical comparison of the uranium concentration revealed no differences between vitrophyres and associated felsites.

  10. Sudden hearing loss and vertigo after tooth extraction successfully treated with combined therapy including HBO2: a case report.

    PubMed

    Yilmaz, Huseyin Baki; Erdogan, Raziye Banu Atalay; Paksoy, Mustafa; Sanli, Arif

    2015-01-01

    Sudden sensorineural hearing loss (SSNHL) is a decrease in hearing of at least 30 dB that occurs within three days and which affects at least three consecutive frequencies in either ear or both ears. This case report describes a woman who had sudden hearing loss and vertigo in the right ear after tooth extraction. As the first-line therapy, systemic and intratympanic steroid injections were used this led to a slight improvement; however, the majority of improvement in hearing was not observed until hyperbaric oxygen (HBO2) therapy was instituted on the 20th day of hearing loss. Sudden hearing loss and vertigo after tooth extraction is an otologic emergency and early evaluation and treatment are effective. HBO2, although employed beyond the Undersea and Hyperbaric Medical Society's recommended initial 14 days of symptom onset, very was effective for this particular case.

  11. Survey of tracking systems and rotary joints for coolant piping. Final report, August 15, 1978-August 14, 1978. [Includes patents

    SciTech Connect

    Furaus, J P; Gruchalla, M E; Sower, G D

    1980-01-01

    Problems were surveyed and evaluated with respect to solar tracking mechanisms and rotary joints for coolant piping. An analytical development of celestial mechanics, one- and two-axis tracking configurations and the effect of tracking accuracy versus collector efficiency are reported. Daily operational requirements and tracking modes were defined and evaluated. A literature and patent search on solar tracking technology was performed. Tracking system and control system performance specifications were determined. Alternative conceptual tracking approaches were defined and a cost and performance evaluation of a mechanical tracking concept was performed. Fluid coupling service specifications were determined. The cost and performance of several types of actuators and error detectors were evaluated with respect to solar tracking mechanisms.

  12. SORBENT DEVELOPMENT FOR MERCURY CONTROL. Final topical report including semiannual for January 1, 1998 through June 30, 1998.

    SciTech Connect

    David J. Hassett; Edwin S. Olson; Grant E. Dunham; Ramesh K. Sharma; Ronald C. Timpe; Stanley J. Miller

    1998-10-01

    The US Environmental Protection Agency (EPA) draft Mercury Study Report to Congress (1) estimated anthropogenic mercury emissions to be 253 tons/yr in the US, with the majority (216 tons/yr) from combustion sources. The three main combustion sources listed were coal (72 tons/yr), medical waste incinerators (65 tons/yr), and municipal waste combustors (64 tons/yr). The emissions from both medical waste incinerators and municipal waste combustors were recently regulated, which, together with the reduction of mercury in consumer products such as batteries and fluorescent lights, has already reduced the emissions from these sources, as stated in the final EPA Mercury Report to Congress (2). EPA now estimates total point-source mercury emissions to be 158 tons/yr, with coal remaining at 72 tons/yr, while medical waste incinerators are down to 16 tons/yr and municipal waste combustors are at 30 tons/yr. Coal is now the primary source of anthropogenic mercury emissions in the US, accounting for 46%. In addition, the use of coal in the US has been increasing every year and passed the 1-billion-ton-per-year mark for the first time in 1997 (3). At the current rate of increase, coal consumption would reach 1.4 billion tons annually by the year 2020. On a worldwide basis, the projected increase in coal usage over the next two decades in China, India, and Indonesia will dwarf the current US coal consumption level. Therefore, in the US coal will be the dominant source of mercury emissions and worldwide coal may be the cause of significantly increased mercury emissions unless an effective control strategy is implemented. However, much uncertainty remains over the most technically sound and cost-effective approach for reducing mercury emissions from coal-fired boilers, and a number of critical research needs will have to be met to develop better control (2).

  13. A New Species of Graphis and New Lichen Records from Vietnam, Including a Second Worldwide Report of Sarcographina cyclospora.

    PubMed

    Joshi, Santosh; Jayalal, Udeni; Oh, Soon-Ok; Nguyen, Thi Thuy; Dzung, Nguyen Anh; Hur, Jae-Seoun

    2014-03-01

    Graphis upretii is a new lichen species discovered in Vietnam. The species is characterized by a loosely corticate, rough, whitish grey to greyish green thallus, elongate and irregularly branched lirellae with an apically thin complete thalline margin (negrosina morph), laterally carbonized, entire proper exciple, clear hymenium, hyaline, 16~20 transversely locular ascospores, and about 50~95 × 10~15 µm in size. In addition, members of the taxon produce norstictic and stictic acids. Currently, the lichen flora of Vietnam include Arthonia radiata, Brigantiaea tricolor, Coenogonium implexum, Dirina paradoxa, Herpothallon sipmanii, Pertusaria pertusa, and Sarcographina cyclospora.

  14. A New Species of Graphis and New Lichen Records from Vietnam, Including a Second Worldwide Report of Sarcographina cyclospora

    PubMed Central

    Joshi, Santosh; Jayalal, Udeni; Oh, Soon-Ok; Nguyen, Thi Thuy; Dzung, Nguyen Anh

    2014-01-01

    Graphis upretii is a new lichen species discovered in Vietnam. The species is characterized by a loosely corticate, rough, whitish grey to greyish green thallus, elongate and irregularly branched lirellae with an apically thin complete thalline margin (negrosina morph), laterally carbonized, entire proper exciple, clear hymenium, hyaline, 16~20 transversely locular ascospores, and about 50~95 × 10~15 µm in size. In addition, members of the taxon produce norstictic and stictic acids. Currently, the lichen flora of Vietnam include Arthonia radiata, Brigantiaea tricolor, Coenogonium implexum, Dirina paradoxa, Herpothallon sipmanii, Pertusaria pertusa, and Sarcographina cyclospora. PMID:24808729

  15. Integrated wastewater management reporting at tourist areas for recycling purposes, including the case study of Hersonissos, Greece.

    PubMed

    Borboudaki, K E; Paranychianakis, N V; Tsagarakis, K P

    2005-10-01

    Wastewater treatment facilities in tourist areas, in comparison to other municipal facilities, require specific configurations and additional management actions in order to achieve a reliable and cost-effective treatment. For example, the same facility operates during winter with minimum flows and in summer with peak flows. Moreover, careful effluent management is required to minimize environmental impact and health effects on tourists. In this study, effluent management data, including quantitative and qualitative effluent characteristics, reuse, and economic aspects of the Hersonissos Wastewater Treatment Plant (WTP) in Greece, are discussed. It has been designed to treat both municipal wastewater from the Hersonissos Municipality and septage from the wider area. Analysis of effluent quantitative data showed two flow peaks in the summer period and only one in winter. The WTP was found to provide a reliable level of treatment in terms of biochemical oxygen demand (95.9%), total suspended solids (97.2%), and total nitrogen (87.7%) removal, but increased numbers of fecal coliforms were measured at some peak flow periods, suggesting the need for additional management strategies. Effluent is reused mainly for agricultural irrigation; secondary uses include fire protection and landscape irrigation. Economic analysis showed that for each cubic meter treated, the total annual economic cost for treatment, filtration, and reuse infrastructure was 1.07 euro, 0.05 euro, and 0.08 euro, respectively.

  16. Antiviral activity of human Vδ2 T-cells against WNV includes both cytolytic and non-cytolytic mechanisms.

    PubMed

    Agrati, Chiara; Castilletti, Concetta; Cimini, Eleonora; Romanelli, Antonella; Lapa, Daniele; Quartu, Serena; Martini, Federico; Capobianchi, Maria Rosaria

    2016-04-01

    West Nile virus (WNV) causes a severe central nervous system infection in humans, primarily in the elderly and immunocompromised subjects. Human γδ T-cells play a critical role in the immune response against viruses, and studies of WNV meningoencephalitis in laboratory mice described a role of γδ T-cells in the protective immune response. Aim of this study was to analyze the cytolytic and non-cytolytic antiviral activity of human Vδ2 T-cells against WNV replication. The anti-WNV activity of soluble factor released by zoledronic acid (ZA)-activated Vδ2 T-cell lines and the cytotoxic capability of Vδ2 T-cell lines against WNV-infected cells were tested in vitro. The activation of Vδ2 T-cell lines was able to inhibit WNV replication through the release of soluble factors. IFN-γ is massively released by activated Vδ2 T-cell lines and is involved in the anti-WNV activity. Moreover, the Vδ2 T-cell lines can efficiently kill WNV-infected cells possibly through perforin-mediated mechanism. Altogether, our results provide insight into the effector functions of human Vδ2 T-cells against WNV. The possibility to target these cells by ZA, a commercially available drug used in humans, could potentially offer a new immunotherapeutic strategy for WNV infection. PMID:27196553

  17. Summary of Changes Related to the Individualized Education Program (IEP): Current Law and 1997 IDEA Amendments, Including Congressional Committee Comments. Final Report.

    ERIC Educational Resources Information Center

    Schrag, Judy; Ahearn, Eileen M.

    This report summarizes provisions and highlights changes for the Individualized Education Program (IEP) within the Individuals with Disabilities Education Act (IDEA) Amendments of 1997. Also included are references from the two Congressional Committee Reports--those of the Senate Labor and Human Resources Committee and the House Committee on…

  18. 303-K Storage Facility report on FY98 closure activities

    SciTech Connect

    Adler, J.G.

    1998-07-17

    This report summarizes and evaluates the decontamination activities, sampling activities, and sample analysis performed in support of the closure of the 303-K Storage Facility. The evaluation is based on the validated data included in the data validation package (98-EAP-346) for the 303-K Storage Facility. The results of this evaluation will be used for assessing contamination for the purpose of closing the 303-K Storage Facility as described in the 303-K Storage Facility Closure Plan, DOE/RL-90-04. The closure strategy for the 303-K Storage Facility is to decontaminate the interior of the north half of the 303-K Building to remove known or suspected dangerous waste contamination, to sample the interior concrete and exterior soils for the constituents of concern, and then to perform data analysis, with an evaluation to determine if the closure activities and data meet the closure criteria. The closure criteria for the 303-K Storage Facility is that the concentrations of constituents of concern are not present above the cleanup levels. Based on the evaluation of the decontamination activities, sampling activities, and sample data, determination has been made that the soils at the 303-K Storage Facility meet the cleanup performance standards (WMH 1997) and can be clean closed. The evaluation determined that the 303-K Building cannot be clean closed without additional closure activities. An additional evaluation will be needed to determine the specific activities required to clean close the 303-K Storage Facility. The radiological contamination at the 303-K Storage Facility is not addressed by the closure strategy.

  19. NSLS 2007 Activity Report (National Synchrotron Light Source Activity Report 2007)

    SciTech Connect

    Miller ,L.; Nasta, K.

    2008-05-01

    The National Synchrotron Light Source is one of the world's most productive and cost-effective user facilities. With 2,219 individual users, about 100 more than last year, and a record-high 985 publications, 2007 was no exception. In addition to producing an impressive array of science highlights, which are included in this Activity Report, many NSLS users were honored this year for their scientific accomplishments. Throughout the year, there were major strides in the development of the scientific programs by strengthening strategic partnerships with major research resources and with the Center for Functional Nanomaterials (CFN). Of particular note, the Consortium for Materials Properties Research in Earth Sciences (COMPRES) received renewed funding for the next five years through the National Science Foundation. COMPRES operates four high-pressure NSLS beamlines--X17B2, X17B3, X17C, and U2A--and serves the earth science community as well as the rapidly expanding segment of researchers using high-pressure techniques in materials, chemical, and energy-related sciences. A joint appointment was made between the NSLS and Stony Brook University to further enhance interactions with COMPRES. There was major progress on two key beamline projects outlined in the Five-Year Strategic Plan: the X25 beamline upgrade and the construction of the X9 small angle scattering (SAXS) beamline. The X25 overhaul, which began with the installation of the in-vacuum mini-gap undulator (MGU) in January 2006, is now complete. X25 is once again the brightest beamline for macromolecular crystallography at the NSLS, and in tandem with the X29 undulator beamline, it will keep the NSLS at the cutting edge in this important area of research. Upgrade work associated with the new MGU and the front end for the X9 SAXS beamline--jointly developed by the NSLS and the CFN--also was completed. Beamline X9 will host the SAXS program that currently exists at beamline X21 and will provide new microbeam SAXS

  20. Thermoeconomic analysis of a gasification-combined-cycle power plant. Final report. [Includes 2nd law evaluation of processes

    SciTech Connect

    Tsatsaronis, G. Winhold, M.; Stojanoff, C.G.

    1986-08-01

    This report presents the results of a study conducted to further develop a thermoeconomic (combined thermodynamic and economic) methodology for the analysis and evaluation of power plants, and to apply the procedures of the methodology to an integrated coal gasification-combined-cycle (IGCC) power plant. The design and cost estimates used in the thermoeconomic analysis are based on the results of a recent comprehensive EPRI study conducted by Fluor Engineers, Inc., with participation of Texaco, Inc., and of the General Electric Company. One basic plant configuration was thermoeconomically analyzed. Results of this study indicate that the cost of net electricity could decrease by increasing capital cost to decrease exergy losses in the gas turbine system, and by improving (reducing the capital cost of) the heat-exchanger network of the total process. Addition of a reheat stage in the gas turbine system can improve overall IGCC plant efficiency by more than 2.5 percentage points. The analyses allow identification and evaluation of the real cost sources, and the opportunities for improvement of any energy-conversion process. The detailed thermoeconomic analysis of the base plant is based on the exergy (useful energy) concept, and enables the costing of the exergy streams flowing between plant components, and the exergy losses (real ''energy'' losses) in these components. The higher the exergy losses, the lower the efficiency of the plant component being investigated. The recommendations from the thermoeconomic analysis are based on comparison between (a) costs of fuel and product of each plant component, and (b) capital costs and costs of exergy losses associated with each plant component. The objective is to find an optimum combination of capital expenditures and efficiency for the major components of the power plant. 21 refs., 19 figs., 33 tabs.

  1. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  2. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  3. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  4. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  5. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  6. 12 CFR 1010.310 - Annual report of activity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Record, the developer shall file with the Director an Annual Report of Activity on any initial or... expected for subdivisions on which developers have filed consolidations. For registrations certified by a state as provided for in § 1010.500, a developer need file only one Annual Report of Activity for...

  7. 12 CFR 1010.310 - Annual report of activity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Record, the developer shall file with the Director an Annual Report of Activity on any initial or... expected for subdivisions on which developers have filed consolidations. For registrations certified by a state as provided for in § 1010.500, a developer need file only one Annual Report of Activity for...

  8. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... § 1710.310 Annual report of activity. (a) As an integral part of the Statement of Record, the developer... subdivisions on which developers have filed consolidations. For registrations certified by a State as provided for in § 1710.500, a developer need file only one Annual Report of Activity for any registration...

  9. 12 CFR 1010.310 - Annual report of activity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Record, the developer shall file with the Director an Annual Report of Activity on any initial or... expected for subdivisions on which developers have filed consolidations. For registrations certified by a state as provided for in § 1010.500, a developer need file only one Annual Report of Activity for...

  10. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... § 1710.310 Annual report of activity. (a) As an integral part of the Statement of Record, the developer... subdivisions on which developers have filed consolidations. For registrations certified by a State as provided for in § 1710.500, a developer need file only one Annual Report of Activity for any registration...

  11. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... § 1710.310 Annual report of activity. (a) As an integral part of the Statement of Record, the developer... subdivisions on which developers have filed consolidations. For registrations certified by a State as provided for in § 1710.500, a developer need file only one Annual Report of Activity for any registration...

  12. 12 CFR 1806.201 - Measuring and reporting Qualified Activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Measuring and reporting Qualified Activities..., DEPARTMENT OF THE TREASURY BANK ENTERPRISE AWARD PROGRAM Awards § 1806.201 Measuring and reporting Qualified... applicable BEA NOFA for current limitations on Qualified Activities. (e) Measuring the Value of...

  13. 12 CFR 208.62 - Suspicious activity reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 2 2013-01-01 2013-01-01 false Suspicious activity reports. 208.62 Section 208.62 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM MEMBERSHIP OF STATE BANKING INSTITUTIONS IN THE FEDERAL RESERVE SYSTEM (REGULATION H) Miscellaneous Requirements § 208.62 Suspicious activity reports....

  14. Mathemagenic Activities Program: [Reports on Constructivism].

    ERIC Educational Resources Information Center

    Smock, Charles D., Ed.

    This set of five papers is related to the Mathemagenic Activities Program (MAP) for early childhood education of the University of Georgia's Follow Through Program. The MAP is based on Piagetian theory and provides sequentially structured sets of curriculum materials and processes that are designed to continually challenge children to learn about…

  15. High water-stressed population estimated by world water resources assessment including human activities under SRES scenarios

    NASA Astrophysics Data System (ADS)

    Kiguchi, M.; Shen, Y.; Kanae, S.; Oki, T.

    2009-04-01

    In an argument of the reduction and the adaptation for the climate change, the evaluation of the influence by the climate change is important. When we argue in adaptation plan from a damage scale and balance with the cost, it is particularly important. Parry et al (2001) evaluated the risks in shortage of water, malaria, food, the risk of the coast flood by temperature function and clarified the level of critical climate change. According to their evaluation, the population to be affected by the shortage of water suddenly increases in the range where temperature increases from 1.5 to 2.0 degree in 2080s. They showed how much we need to reduce emissions in order to draw-down significantly the number at risk. This evaluation of critical climate change threats and targets of water shortage did not include the water withdrawal divided by water availability. Shen et al (2008a) estimated the water withdrawal of projection of future world water resources according to socio-economic driving factors predicted for scenarios A1b, A2, B1, and B2 of the Special Report on Emission Scenarios (SRES). However, these results were in function of not temperature but time. The assessment of the highly water-stressed population considered the socioeconomic development is necessary for a function of the temperature. Because of it is easy to understand to need to reduce emission. We present a multi-GCM analysis of the global and regional populations lived in highly water-stressed basin for a function of the temperature using the socioeconomic data and the outputs of GCMs. In scenario A2, the population increases gradually with warming. On the other hand, the future projection population in scenario A1b and B1 increase gradually until the temperature anomaly exceeds around from +1 to +1.5 degree. After that the population is almost constant. From Shen et al (2008b), we evaluated the HWSP and its ratio in the world with temperature function for scenarios A1B, A2, and B1 by the index of W

  16. 14 CFR 440.11 - Duration of coverage for licensed launch, including suborbital launch, or permitted activities...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... LICENSING FINANCIAL RESPONSIBILITY Financial Responsibility for Licensed and Permitted Activities § 440.11...; modifications. (a) Insurance coverage required under § 440.9, or other form of financial responsibility, shall... recovery; or (ii) The FAA's determination that risk to third parties and Government property as a result...

  17. Activated Notch1 Target Genes during Embryonic Cell Differentiation Depend on the Cellular Context and Include Lineage Determinants and Inhibitors

    PubMed Central

    Meier-Stiegen, Franziska; Schwanbeck, Ralf; Bernoth, Kristina; Martini, Simone; Hieronymus, Thomas; Ruau, David; Zenke, Martin; Just, Ursula

    2010-01-01

    Background Notch receptor signaling controls developmental cell fates in a cell-context dependent manner. Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the target genes that are directly activated by Notch in the respective tissues. Methodology/Principal Findings To analyze how Notch signaling mediates its context dependent function(s), we utilized a Tamoxifen-inducible system to activate Notch1 in murine embryonic stem cells at different stages of mesodermal differentiation and performed global transcriptional analyses. We find that the majority of genes regulated by Notch1 are unique for the cell type and vary widely dependent on other signals. We further show that Notch1 signaling regulates expression of genes playing key roles in cell differentiation, cell cycle control and apoptosis in a context dependent manner. In addition to the known Notch1 targets of the Hes and Hey families of transcriptional repressors, Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis. Conclusion/Significance We suggest that Notch signaling determines lineage decisions and expansion of stem cells by directly activating both key lineage specific transcription factors and their repressors (Id and Hes/Hey proteins) and propose a model by which Notch signaling regulates cell fate commitment and self renewal in dependence of the intrinsic and extrinsic cellular context. PMID:20628604

  18. U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)

    USGS Publications Warehouse

    Tony K. Meunier Edited by Williams, Richard S.; Ferrigno, Jane G.

    2007-01-01

    3) significant changes that have occurred in Antarctic exploration and research since World War II will be discussed at the end of this report. Subsequent Open-File Reports will provide a year-by-year documentation of USGS scientific activities and accomplishments in Antarctica beginning with the post-IGY, 1959-60 research team. One Open-File Report is planned to be written for each field-based season. For an example of the series format, see Open-File Reports 2006-1113 (Meunier, 2007a) and 2006-1114 (Meunier, 2007b). This report is a companion document to Open-File Report 2006-1116 (Meunier, 2007c). The USGS mapping and science programs in Antarctica are among the longest continuously funded projects in the United States Antarctic Program (USAP). The 2005-06 field season is the 56th consecutive U.S. expedition in which USGS scientists have been participants, starting in 1946. USGS and the National Science Foundation (NSF) cooperation began with the establishment by NSF of the U.S. Antarctic (Research) Program [USA(R)P] in 1958-59 under Operation Deep Freeze IV (DF IV) and was given the responsibility for the principal coordination and management of all U.S. scientific activities in Antarctica in Deep Freeze 60 (DF 60) (1959-60). Financial support from NSF, mostly in the form of Memorandum of Understandings (MOUs) and Cooperative Agreements, extends back to this period and can be attributed to the need for accurate geologic, geophysical, and topographic base maps of specific field areas or regions where NSF-funded science projects were planned. The epoch of Antarctic exploration during the IGY was driven by science and, in a spirit of peaceful cooperation, the international scientific community wanted to limit military activities on the continent to logistical support (Meunier, 1979 [2007], p. 38). The USGS, a Federal civilian science agency in the Department of the Interior, has, since its founding in 1879, carried out numerous field-based national (and some

  19. Performance of Trasuranic-Loaded Fully Ceramic Micro-Encapsulated Fuel in LWRs Interim Report, Including Void Reactivity Evaluation

    SciTech Connect

    Michael A. Pope; Brian Boer; Gilles Youinou; Abderrafi M. Ougouag

    2011-03-01

    The current focus of the Deep Burn Project is on once-through burning of transuranice (TRU) in light water reactors (LWRs). The fuel form is called Fully-Ceramic Micro-encapsulated (FCM) fuel, a concept that borrows the tri-isotropic (TRISO) fuel particle design from high-temperature reactor technology. In the Deep Burn LWR (DB-LWR) concept, these fuel particles would be pressed into compacts using SiC matrix material and loaded into fuel pins for use in conventional LWRs. The TRU loading comes from the spent fuel of a conventional LWR after 5 years of cooling. Unit cell calculations have been performed using the DRAGON-4 code in order assess the physics attributes of TRU-only FCM fuel in an LWR lattice. Depletion calculations assuming an infinite lattice condition were performed with calculations of various reactivity coefficients performed at each step. Unit cells containing typical UO2 and MOX fuel were analyzed in the same way to provide a baseline against which to compare the TRU-only FCM fuel. Loading of TRU-only FCM fuel into a pin without significant quantities of uranium challenges the design from the standpoint of several key reactivity parameters, particularly void reactivity, and to some degree, the Doppler coefficient. These unit cells, while providing an indication of how a whole core of similar fuel would behave, also provide information of how individual pins of TRU-only FCM fuel would influence the reactivity behavior of a heterogeneous assembly. If these FCM fuel pins are included in a heterogeneous assembly with LEU fuel pins, the overall reactivity behavior would be dominated by the uranium pins while attractive TRU destruction performance of the TRU-only FCM fuel pins may be preserved. A configuration such as this would be similar to CONFU assemblies analyzed in previous studies. Analogous to the plutonium content limits imposed on MOX fuel, some amount of TRU-only FCM pins in an otherwise-uranium fuel assembly may give acceptable reactivity

  20. Report: Antimicrobial activity of Kalanchoe laciniata.

    PubMed

    Manan, Maria; Hussain, Liaqat; Ijaz, Hira; Qadir, Muhammad Imran

    2016-07-01

    This study was conducted to identify antimicrobial potential of Kalanchoe laciniata. The plants were extracted with 30-70% aqueous-methanol and n-hexane. The antimicrobial activities were examined using agar well diffusion method against bacteria (Staphylococcus aureus, Escherichia coli) and fungi (Candidaalbicans). Results showed that E. coli were more sensitive than Staphylococcus aureus and Candida albicans. The largest zone of inhibition (52 mm) was recorded against E. coli with the n-hexane extract of Kalanchoe laciniata.

  1. Weight management including dietary and physical activity advice provided by Australian physiotherapists: a pilot cross-sectional survey.

    PubMed

    Snodgrass, Suzanne J; Carter, Amy E; Guest, Maya; Collins, Clare E; James, Carole; Kable, Ashley K; Ashby, Samantha E; Plotnikoff, Ronald C

    2014-08-01

    Physiotherapists may have an impact on obesity prevention and treatment by providing nutrition and physical activity advice to overweight or obese clients; yet little is known about physiotherapists' beliefs and practices related to client weight management. The aim of this pilot study was to determine the practices, beliefs, attitudes and knowledge of physiotherapists regarding the provision of weight management advice to overweight or obese clients. Physiotherapists (n = 65) working in multiple practice settings completed a self-administered questionnaire. Logistic regression determined factors associated with the provision of dietary and physical activity advice for weight management. The majority of physiotherapists (n = 53 [81.5%]) believed providing weight management advice was within their scope of practice, yet only a minority had received training during their professional entry level education (n = 13 [20%]) or through professional development (n = 7 [11%]). Most physiotherapists (n = 55 [84.6%]) provided physical activity advice for weight management, but a minority (n = 27 [41.5%]) provided dietary advice. Having received training in weight management during their professional entry level education was associated with providing dietary advice (Odds ratio 8.8, 95% confidence interval 2.0-38.9, p = 0.004). Training in weight management may increase the likelihood of physiotherapists providing dietary advice, improving physiotherapists' management of obesity.

  2. The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA–Dependent Tel1 Activation

    PubMed Central

    Iwasaki, Daichi; Hayashihara, Kayoko; Shima, Hiroki; Higashide, Mika; Terasawa, Masahiro; Gasser, Susan M.; Shinohara, Miki

    2016-01-01

    Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex, and its function is critical for the primary step of DSB repair, whether by homologous recombination (HR) or non-homologous end joining. In human NBS1, mutations result truncation of the N-terminus region, which contains a forkhead-associated (FHA) domain, cause Nijmegen breakage syndrome. Here we show that the Xrs2 FHA domain of budding yeast is required both to suppress the imprecise repair of DSBs and to promote the robust activation of Tel1 in the DNA damage response pathway. The role of the Xrs2 FHA domain in Tel1 activation was independent of the Tel1-binding activity of the Xrs2 C terminus, which mediates Tel1 recruitment to DSB ends. Both the Xrs2 FHA domain and Tel1 were required for the timely removal of the Ku complex from DSB ends, which correlates with a reduced frequency of imprecise end-joining. Thus, the Xrs2 FHA domain and Tel1 kinase work in a coordinated manner to maintain DSB repair fidelity. PMID:26990569

  3. The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

    PubMed Central

    Bottardi, Stefania; Mavoungou, Lionel; Pak, Helen; Daou, Salima; Bourgoin, Vincent; Lakehal, Yahia A.; Affar, El Bachir; Milot, Eric

    2014-01-01

    IKAROS is a critical regulator of hematopoietic cell fate and its dynamic expression pattern is required for proper hematopoiesis. In collaboration with the Nucleosome Remodeling and Deacetylase (NuRD) complex, it promotes gene repression and activation. It remains to be clarified how IKAROS can support transcription activation while being associated with the HDAC-containing complex NuRD. IKAROS also binds to the Positive-Transcription Elongation Factor b (P-TEFb) at gene promoters. Here, we demonstrate that NuRD and P-TEFb are assembled in a complex that can be recruited to specific genes by IKAROS. The expression level of IKAROS influences the recruitment of the NuRD-P-TEFb complex to gene regulatory regions and facilitates transcription elongation by transferring the Protein Phosphatase 1α (PP1α), an IKAROS-binding protein and P-TEFb activator, to CDK9. We show that an IKAROS mutant that is unable to bind PP1α cannot sustain gene expression and impedes normal differentiation of IkNULL hematopoietic progenitors. Finally, the knock-down of the NuRD subunit Mi2 reveals that the occupancy of the NuRD complex at transcribed regions of genes favors the relief of POL II promoter-proximal pausing and thereby, promotes transcription elongation. PMID:25474253

  4. Simultaneous BVI noise and vibration reduction in rotorcraft using actively-controlled flaps and including performance considerations

    NASA Astrophysics Data System (ADS)

    Patt, Daniel A.

    This work presents the development and application of an active control approach for reduction of both vibration and noise induced by helicopter rotor blade vortex interaction (BVI). Control is implemented through single or dual actively controlled flaps (ACFs) on each blade. Low-speed helicopter flight is prone to severe BVI, resulting in elevated vibration and noise levels. Existing research has suggested that when some form of active control is used to reduce vibration, noise will increase and vice versa. The present research achieves simultaneous reduction of noise and vibration, and also investigates the physical sources of the observed reduction. The initial portion of this work focused on developing a tool for simulating helicopter noise and vibrations in the BVI flight regime. A method for predicting compressible unsteady blade surface pressure distribution on rotor blades was developed and combined with an enhanced free-wake model and an acoustic prediction tool with provisions for blade flexibility. These elements were incorporated within an aeroelastic analysis featuring fully coupled flap-lag-torsional blade dynamics. Subsequently, control algorithms were developed that were effective for reducing noise and vibration even in the nonlinear BVI flight regime; saturation limits were incorporated constraining flap deflections to specified limits. The resulting simulation was also validated with a wide range of experimental data, achieving excellent correlation. Finally, a number of active control studies were performed. Multi-component vibration reductions of 40--80% could be achieved, while incurring a small noise penalty. Noise was reduced using an onboard feedback microphone; reductions of 4--10 dB on the advancing side were observed on a plane beneath the rotor when using dual flaps. Finally, simultaneous noise and vibration reduction was studied. A reduction of about 5 dB in noise on the advancing side combined with a 60% reduction in vibration was

  5. Differential partitioning of antioxidants, including hydroxytyrosol, in human plasma and LDL: implications for their antioxidant activity in vivo.

    PubMed

    Visioli, Francesco; Colombo, Claudio; Galli, Claudio

    2012-05-01

    In vivo studies of LDL oxidation following consumption of natural phenolic compounds have yielded mixed results. It is reported that the amphiphilic hydroxytyrosol, after addition to human plasma, does not accumulate in LDL but protects plasma lipids, which are extracted together with hydroxytyrosol, from chemically-induced oxidation. Thus, a novel methodology was proposed, which does not rely on LDL separation and subsequent oxidation but is based on the oxidation of total lipids - simultaneously extracted from plasma with antioxidants - to evaluate the effects of micronutrients that do not partition into LDL, after in vivo supplementation.

  6. Catawba Science Center solar activities. Final report

    SciTech Connect

    1983-01-01

    Two demonstration solar water heaters were built. One was to be used at the Science Center and the other with traveling programs. This was completed and both units are being used for these programs which continue. We were able to build a library of 99 solar energy books and booklets that are available to the public for reference. We also conducted programs for 683 students of all ages. The culminating activity was the planned Energy Awareness Festival. This was held on September 26, 1981 and attracted 450 area citizens. We offered free exhibit space and hosted 17 exhibitors.

  7. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Schofield, N. J., Jr.; Littlefield, R. G.; Elsen, M. F.

    1985-01-01

    This report provides the professional community with information on current and planned spacecraft activity (including both free-flying spacecraft and Shuttle-attached payloads) for a broad range of scientific disciplines. By providing a brief description of each spacecraft and experiment as well as its current status, it is hoped that this document will be useful to many people interested in the scientific, applied, and operational uses of the data collected. Furthermore, for those investigators who are planning or coordinating future observational programs employing a number of different techniques such as rockets, balloons, aircraft, ships, and buoys, this document can provide some insight into the contributions that may be provided by orbiting instruments. The document includes information concerning active and planned spacecraft and experiments. The information covers a wide range of scientific disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and funding of individual countries, as well as cooperative arrangements among different countries.

  8. The Influence of Organized Physical Activity (including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed Central

    Bernardoni, Brittney; Scerpella, Tamara A.; Rosenbaum, Paula F.; Kanaley, Jill A.; Raab, Lindsay N.; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N.

    2015-01-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semi-annual records of anthropometry, maturity and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year pre-menarche [predictor] and ~5 years post-menarche [dependent variable]). Regression analysis evaluated total adolescent inter-scan PA and PA over 3 maturity sub-phases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry and strength indices at non-dominant distal radius and femoral neck; 2) sub-head BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or post-menarche), baseline bone status, adult body size and inter-scan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p<0.07). Pre-menarcheal bone traits were strong predictors of most adult outcomes (semi-partial r2 = 0.21-0.59, p≤0.001). Adult 1/3 radius and sub-head BMC were predicted by both total PA and PA 1-3 years post-menarche (p<0.03). PA 3-5 years post-menarche predicted femoral narrow neck width, endosteal diameter and buckling ratio (p<0.05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females. PMID:25386845

  9. The Influence of Organized Physical Activity (Including Gymnastics) on Young Adult Skeletal Traits: Is Maturity Phase Important?

    PubMed

    Bernardoni, Brittney; Scerpella, Tamara A; Rosenbaum, Paula F; Kanaley, Jill A; Raab, Lindsay N; Li, Quefeng; Wang, Sijian; Dowthwaite, Jodi N

    2015-05-01

    We prospectively evaluated adolescent organized physical activity (PA) as a factor in adult female bone traits. Annual DXA scans accompanied semiannual records of anthropometry, maturity, and PA for 42 participants in this preliminary analysis (criteria: appropriately timed DXA scans at ~1 year premenarche [predictor] and ~5 years postmenarche [dependent variable]). Regression analysis evaluated total adolescent interscan PA and PA over 3 maturity subphases as predictors of young adult bone outcomes: 1) bone mineral content (BMC), geometry, and strength indices at nondominant distal radius and femoral neck; 2) subhead BMC; 3) lumbar spine BMC. Analyses accounted for baseline gynecological age (years pre- or postmenarche), baseline bone status, adult body size and interscan body size change. Gymnastics training was evaluated as a potentially independent predictor, but did not improve models for any outcomes (p > .07). Premenarcheal bone traits were strong predictors of most adult outcomes (semipartial r2 = .21-0.59, p ≤ .001). Adult 1/3 radius and subhead BMC were predicted by both total PA and PA 1-3 years postmenarche (p < .03). PA 3-5 years postmenarche predicted femoral narrow neck width, endosteal diameter, and buckling ratio (p < .05). Thus, participation in organized physical activity programs throughout middle and high school may reduce lifetime fracture risk in females. PMID:25386845

  10. RILEM TC ISR Summer 2015 Activity Report

    SciTech Connect

    Le Pape, Yann

    2015-08-01

    With aging infrastructures, instances of Alkali Silica Reaction (ASR) and Delayed Ettringite Formation (DEF), broadly covered under the term Internal Swelling Reaction (ISR), are increasingly being detected. They have been observed in bridges, dams, and most recently in nuclear power plants. Concrete swelling may result in bridge partial failure, dams with structural cracks and misaligned turbine shafts, and locked slice gates. For nuclear reactors micro-cracks may cause increased gas permeability which will jeopardize the containment integrity and may decrease the residual structural resistance under accidental loading. This TC, which limits its activity to structures with known expansive concrete, seeks to address two complementary but fundamental questions: a) What is the kinetics of the reaction and b) How would it affect the integrity of the structure (serviceability and strength) and thus establish a science based prognostic to the structure owner.

  11. New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

    PubMed Central

    La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Sisinni, Lorenza; Bolognesi, Alessio; Rensen, Whilelmina Maria; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, Andrea; Novellino, Ettore; Dondio, Giulio; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano

    2014-01-01

    We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro the Hedgehog signaling pathway, strongly reducing luciferase activity in SAG treated NIH3T3 Shh-Light II cells, and inhibited the growth of medulloblastoma D283 cells at nanomolar concentrations. ARAPs 22 and 27 represent a new potent class of tubulin polymerization and cancer cell growth inhibitors with the potential to inhibit the Hedgehog signaling pathway. PMID:25025991

  12. Advanced Light Source: Activity report 1993

    SciTech Connect

    Not Available

    1994-11-01

    The Advanced Light Source (ALS) produces the world`s brightest light in the ultraviolet and soft x-ray regions of the spectrum. The first low-energy third-generation synchrotron source in the world, the ALS provides unprecedented opportunities for research in science and technology not possible anywhere else. This year marked the beginning of operations and the start of the user research program at the ALS, which has already produced numerous high quality results. A national user facility located at Lawrence Berkeley Laboratory of the University of California, the ALS is available to researchers from academia, industry, and government laboratories. This report contains the following: (1) director`s message; (2) operations overview; (3) user program; (4) users` executive committee; (5) industrial outreach; (6) accelerator operations; (7) beamline control system; (8) insertion devices; (9) experimental systems; (10) beamline engineering; (11) first results from user beamlines; (12) beamlines for 1994--1995; (13) special events; (14) publications; (15) advisory panels; and (16) ALS staff.

  13. Severe Accident Test Station Activity Report

    SciTech Connect

    Pint, Bruce A.; Terrani, Kurt A.

    2015-06-01

    Enhancing safety margins in light water reactor (LWR) severe accidents is currently the focus of a number of international R&D programs. The current UO2/Zr-based alloy fuel system is particularly susceptible since the Zr-based cladding experiences rapid oxidation kinetics in steam at elevated temperatures. Therefore, alternative cladding materials that offer slower oxidation kinetics and a smaller enthalpy of oxidation can significantly reduce the rate of heat and hydrogen generation in the core during a coolant-limited severe accident. In the U.S. program, the high temperature steam oxidation performance of accident tolerant fuel (ATF) cladding solutions has been evaluated in the Severe Accident Test Station (SATS) at Oak Ridge National Laboratory (ORNL) since 2012. This report summarizes the capabilities of the SATS and provides an overview of the oxidation kinetics of several candidate cladding materials. A suggested baseline for evaluating ATF candidates is a two order of magnitude reduction in the steam oxidation resistance above 1000ºC compared to Zr-based alloys. The ATF candidates are categorized based on the protective external oxide or scale that forms during exposure to steam at high temperature: chromia, alumina, and silica. Comparisons are made to literature and SATS data for Zr-based alloys and other less-protective materials.

  14. Report on 1992/1993 activities

    SciTech Connect

    Russell, T.P.

    1996-07-01

    Over the past several years, at least four different techniques have been developed for probing the behavior of homopolymers and block copolymers at surfaces and interfaces. These include neutron reflectivity, grazing incidence x-ray scattering, dynamic secondan, ion mass spectrometry and electron microscopy. In the upcoming year It is proposed to make key uses of these developments to gain a quantitative understanding of the Interfacial behavior of homopolymers and block copolymers. In addition, the newly discovered lower disorder to order phase transition will be investigated further, is the role a surface or an interface plays in influencing the structure and segmental distribution of polymers in the vicinity of an interface. These areas are outlined below.

  15. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation.

  16. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.

    PubMed

    Mahoney, J Matthew; Titiz, Ali S; Hernan, Amanda E; Scott, Rod C

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation. PMID:26866597

  17. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay

    PubMed Central

    Mahoney, J. Matthew; Titiz, Ali S.; Hernan, Amanda E.; Scott, Rod C.

    2016-01-01

    Hippocampal neural systems consolidate multiple complex behaviors into memory. However, the temporal structure of neural firing supporting complex memory consolidation is unknown. Replay of hippocampal place cells during sleep supports the view that a simple repetitive behavior modifies sleep firing dynamics, but does not explain how multiple episodes could be integrated into associative networks for recollection during future cognition. Here we decode sequential firing structure within spike avalanches of all pyramidal cells recorded in sleeping rats after running in a circular track. We find that short sequences that combine into multiple long sequences capture the majority of the sequential structure during sleep, including replay of hippocampal place cells. The ensemble, however, is not optimized for maximally producing the behavior-enriched episode. Thus behavioral programming of sequential correlations occurs at the level of short-range interactions, not whole behavioral sequences and these short sequences are assembled into a large and complex milieu that could support complex memory consolidation. PMID:26866597

  18. Report on the Activities of the Single Parent Resource Center, 1975-1976.

    ERIC Educational Resources Information Center

    Childcare Switchboard / Single Parent Resource Center, San Francisco, CA.

    This report provides a model for the provision of social services to single parents. The activities the center provides include drop-in support groups, workshops on single parent issues, a single parent magazine, individual counseling and community outreach. The report briefly specifies the goals of the center and the rationale behind its…

  19. Product and rate determinations with chemically activated nucleotides in the presence of various prebiotic materials, including other mono- and polynucleotides

    NASA Technical Reports Server (NTRS)

    Kanavarioti, A.; Alberas, D. J.; Rosenbach, M. T.; Bernasconi, C. F.; Chang, S.

    1991-01-01

    We are investigating the reactions of ImpN's in the presence of a number of prebiotically plausible materials, such as metal ions, phosphate, amines and other nucleotides and hope to learn more about the stability/reactivity of ImpN's in a prebiotic aqueous environment. We find that, in the presence of phosphate, ImpN's form substantial amounts of diphosphate nucleotides. These diphosphate nucleotides are not very good substrates for template directed reactions, but are chemically activated and are known to revert to the phosphoimidazolides in the presence of imidazole under solid state conditions. With respect to our studies of the oligomerization reaction, the determination of the dimerization rate constant of a specific ImpN (guanosine 5'-phospho 2 methylimidazolide) both in the absence and the presence of the template leads to the conclusion that at 37 C the dimerization is not template directed, although the subsequent polymerization steps are. In other words, this specific polynucleotide synthesizing system favors the elongation of oligonucleotides as compared with the formation of dimers and trimers. This favoring of the synthesis of long as opposed to short oligonucleotides may be regarded as a rudimentary example of natural selection at the molecular level.

  20. A comparison of methods of assessment of body composition including neutron activation analysis of total body nitrogen.

    PubMed

    Lukaski, H C; Mendez, J; Buskirk, E R; Cohn, S H

    1981-08-01

    Fourteen healthy men underwent determinations of total body nitrogen (TBN) by prompt gamma neutron activation analysis and total body potassium (TBK) by whole body counting to estimate the muscle and nonmuscle components of the fat-free body mass (FFBM) and their protein contents. Comparison of FFBM estimated from TBN and TBK (60.6 +/- 6.9 kg, mean +/- SD), densitometry (62.3 +/- 7.1 kg), TBK alone (62.2 +/- 8.0 kg) and TBW (63.9 +/- 7.8 kg) showed no differences among the techniques. Similarly, there were neither differences in fat mass nor percent body fat among the methods. Analysis of the chemical composition of FFBM of this group showed TBK/FFBM = 62.6 +/- 2.3 mEq/kg, TBW/FFBM = 74.6 +/- 0.2%, TBN/FFBM = 32.74 +/- 1.09 g/kg, protein/FFBM = 20.5+/- 0.7%. The calculated mineral content of the FFBM was 6.4%. These values are strikingly similar to the values calculated by direct chemical analysis. It was concluded that the combined TBN-TBK method is a valid technique for estimating body composition in man.

  1. Hydrogen storage on activated carbon. Final report

    SciTech Connect

    Schwarz, J.A.

    1994-11-01

    The project studied factors that influence the ability of carbon to store hydrogen and developed techniques to enhance that ability in naturally occurring and factory-produced commercial carbon materials. During testing of enhanced materials, levels of hydrogen storage were achieved that compare well with conventional forms of energy storage, including lead-acid batteries, gasoline, and diesel fuel. Using the best materials, an electric car with a modern fuel cell to convert the hydrogen directly to electricity would have a range of over 1,000 miles. This assumes that the total allowable weight of the fuel cell and carbon/hydrogen storage system is no greater than the present weight of batteries in an existing electric vehicle. By comparison, gasoline cars generally are limited to about a 450-mile range, and battery-electric cars to 40 to 60 miles. The project also developed a new class of carbon materials, based on polymers and other organic compounds, in which the best hydrogen-storing factors discovered earlier were {open_quotes}molecularly engineered{close_quotes} into the new materials. It is believed that these new molecularly engineered materials are likely to exceed the performance of the naturally occurring and manufactured carbons seen earlier with respect to hydrogen storage.

  2. Eighteenth annual report of the United States Geological Survey to the Secretary of the Interior, 1896-1897: Part I - Director's report, including triangulation and spirit leveling

    USGS Publications Warehouse

    Walcott, Charles D.

    1897-01-01

    The most important change in the field work was rendered necessary by the legislation providing for the establishment of levels and permanent monuments and bench marks. The clauses of the act embodying this legislation, and a full statement of the reasons for it, were given in the Introduction to Part I of the Seventeenth Annual Report, pages 7 to 11, and the subject is again referred to further on in this report. The actual cost of the leveling and monuments for the year was somewhat greater than it will be another year, as the expense of training men and initiating the new methods- of survey will not have to be met hereafter. During the year 10,840 miles of levels were run and 1,820 bench marks were established.

  3. Novel stilbenoids, including cannabispiradienone glycosides, from Tragopogon tommasinii (Asteraceae, Cichorieae) and their potential anti-inflammatory activity.

    PubMed

    Granica, Sebastian; Piwowarski, Jakub P; Randazzo, Antonio; Schneider, Peter; Żyżyńska-Granica, Barbara; Zidorn, Christian

    2015-09-01

    A phytochemical investigation of Tragopogon tommasinii Sch.Bip. (Asteraceae, Cichorieae) yielded a total of 21 natural products, two simple phenolic acids (4-hydroxybenzoic acid and p-coumaric acid), four caffeic acid derivatives (chlorogenic acid, 3-O-caffeoylquinic acid, 3,5-O-dicaffeoylquinic acid, and 4,5-O-dicaffeoylquinic acid), six flavonoids (luteolin, luteolin 7-O-glucoside, vitexin, orientin, quercetin 3-O-glucoside, and isorhamnetin 3-O-glucoside), three simple bibenzyls [2-carboxyl-5-hydroxy-3-methoxy-4'-β-glucopyranosyl-oxybibenzyl, 3-caffeoyl-(9→5)-β-apiosyl-(1→6)-β-glucopyranosyloxy-5,4'-dihydroxy-3'-methoxybibenzyl, 3-caffeoyl-(9→5)-β-apiosyl-(1→6)-β-glucopyranosyloxy-4'-dihydroxy-5,3'-dimethoxybibenzyl], three phtalides [3-(4-β-glucopyranosyloxybenzyl)-7-hydroxy-5-methoxyphtalide, 7-β-glucopyranosyloxy-(S)-3-(4-hydroxybenzyl)-5-methoxyphtalide, and 7-(1→6)-α-rhamnosyl-β-glucopyranosyloxy-(S)-3-(4-hydroxybenzyl)-5-methoxyphtalide], two cannabispiradienone derivatives [3-O-β-glucopyranosyldemethoxycannabispiradienone and 3-caffeoyl-(9→5)-β-apiosyl-(1→6)-β-glucopyranosyloxydemethoxycannabispiradienone], and tetra-N-coumaroyl spermine. The three bibenzyls, the latter two benzylphthalides, and both cannabispiradienone derivatives represent new natural compounds and all compounds, except the caffeic acid derivatives and the flavonoids were new for T. tommasinii. The structures were established by HR mass spectrometry, extensive 1D and 2D NMR spectroscopy, and CD spectroscopy. Moreover, the potential anti-inflammatory activities of the new compounds were assayed using human neutrophils and their production of IL-1b, IL-8, TNF-α and MMP-9 as well as the expression of TLR-4, respectively.

  4. Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy

    PubMed Central

    Wiegand, Ann; Shao, Wei; Coffin, John M.; Mellors, John W.; Lederman, Michael; Gandhi, Rajesh T.; Keele, Brandon F.

    2015-01-01

    ABSTRACT Understanding the origin of HIV variants during viral rebound may provide insight into the composition of the HIV reservoir and has implications for the design of curative interventions. HIV single-genome sequences were obtained from 10 AIDS Clinical Trials Group participants who underwent analytic antiretroviral therapy (ART) interruption (ATI). Rebounding variants were compared with those in pre-ART plasma in all 10 participants and with on-ART peripheral blood mononuclear cell (PBMC)-associated DNA and RNA (CA-RNA) in 7/10 participants. The highest viral diversities were found in the DNA and CA-RNA populations. In 3 of 7 participants, we detected multiple, identical DNA and CA-RNA sequences during suppression on ART that exactly matched plasma HIV sequences. Hypermutated DNA and CA-RNA were detected in four participants, contributing to diversities in these compartments that were higher than in the pre-ART and post-ATI plasma. Shifts in the viral rebound populations could be detected in some participants over the 2- to 3-month observation period. These findings suggest that a source of initial rebound viremia could be populations of infected cells that clonally expanded prior to and/or during ART, some of which were already expressing HIV RNA before treatment was interrupted. These clonally expanding populations of HIV-infected cells may represent an important target for strategies aimed at achieving reservoir reduction and sustained virologic remission. IMPORTANCE Antiretroviral therapy alone cannot eradicate the HIV reservoir, and viral rebound is generally rapid after treatment interruption. It has been suggested that clonal expansion of HIV-infected cells is an important mechanism of HIV reservoir persistence, but the contribution of these clonally proliferating cells to the rebounding virus is unknown. We report a study of AIDS Clinical Trials Group participants who underwent treatment interruption and compared rebounding plasma virus with that

  5. Environmental Activities for Teaching Critical Thinking. [Environmental Education Information Report.

    ERIC Educational Resources Information Center

    Howe, Robert W.; Disinger, John F.

    The ability to think critically is essential if individuals are to live, work, and function effectively in our current and changing society. The activities included in this publication were selected to identify a variety of effective strategies for teaching critical thinking skills through environmental education. Activities include library…

  6. Aeronautics and Space Report of the President: Fiscal Year 2001 Activities

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a 'comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year.' In recent years the reports have been prepared on a fiscal-year basis consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2000, through September 30, 2001.

  7. Aeronautics and Space Report of the President: Fiscal Year 2003 Activities

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year. In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2002, through September 30, 2003.

  8. Aeronautics and Space Report of the President - Fiscal Year 2010 Activities

    NASA Technical Reports Server (NTRS)

    2011-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2009, through September 30, 2010.

  9. Aeronautics and Space Report of the President - Fiscal Year 2008 Activities

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2007, through September 30, 2008.

  10. Aeronautics and Space Report of the President: Fiscal Year 2007 Activities

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 2006, through September 30, 2007.

  11. Aeronautics and Space Report of the President: Fiscal Year 2000 Activities

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1999, through September 30, 2000.

  12. Aeronautics and Space Report of the President: Fiscal Year 1999 Activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1998, through September 30, 1999.

  13. Aeronautics and Space Report of the President: Fiscal Year 2005 Activities

    NASA Technical Reports Server (NTRS)

    2007-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year." In recent years, the reports have been prepared on a fiscal-year basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1 , 2004, through September 30, 2005.

  14. NASA's Microgravity Technology Report: Summary of Activities 1997

    NASA Technical Reports Server (NTRS)

    Woodard, Dan

    1998-01-01

    The purpose of the 1997 NASA Microgravity Technology Report is to update the Microgravity Research Program's technology development policy and to present and assess current technology related activities and requirements identified within its research and technology disciplines.

  15. Despite 2007 law requiring FDA hotline to be included in print drug ads, reporting of adverse events by consumers still low.

    PubMed

    Du, Dongyi; Goldsmith, John; Aikin, Kathryn J; Encinosa, William E; Nardinelli, Clark

    2012-05-01

    In 2007 the federal government began requiring drug makers to include in their print direct-to-consumer advertisements information for consumers on how to contact the Food and Drug Administration directly, either by phone or through the agency's website, to report any adverse events that they experienced after taking a prescription drug. Adverse events can range from minor skin problems like itching to serious injuries or illness that result in hospitalization, permanent disability, or even death. Even so, current rates of adverse event reporting are low. We studied adverse event reports about 123 drugs that came from patients before and after the enactment of the print advertising requirement and estimated that requirement's impact with model simulations. We found that if monthly spending on print direct-to-consumer advertising increased from zero to $7.7 million per drug, the presence of the Food and Drug Administration contact information tripled the increase in patient-reported adverse events, compared to what would have happened in the absence of the law. However, the absolute monthly increase was fewer than 0.24 reports per drug, suggesting that the public health impact of the increase was small and that the adverse event reporting rate would still be low. The study results suggest that additional measures, such as more publicity about the Adverse Event Reporting System or more consumer education, should be considered to promote patient reporting of adverse events.

  16. Space shuttle orbiter avionics software: Post review report for the entry FACI (First Article Configuration Inspection). [including orbital flight tests integrated system

    NASA Technical Reports Server (NTRS)

    Markos, H.

    1978-01-01

    Status of the computer programs dealing with space shuttle orbiter avionics is reported. Specific topics covered include: delivery status; SSW software; SM software; DL software; GNC software; level 3/4 testing; level 5 testing; performance analysis, SDL readiness for entry first article configuration inspection; and verification assessment.

  17. Guidelines to Expand the Certificate of Conformance Program for Financial Reporting to [Include] Junior and Community Colleges. Informational Bulletin No. 14A.

    ERIC Educational Resources Information Center

    Association of School Business Officials, Chicago, IL. Research Corp.

    This booklet presents recommendations for expanding the Certificate of Conformance Program for Financial Reporting of the Association of School Business Officials (ASBO) to include junior and community colleges. The guidelines were developed by participants in an ASBO research workshop on accounting and finance held in July 1974. The guidelines…

  18. Initial Perceptions of English as a Second Language Educators on Including Students with Limited English Proficiency in Minnesota's High Standards. State Assessment Series, Minnesota Report 33.

    ERIC Educational Resources Information Center

    Swierzbin, Bonnie; Liu, Kristin; Thurlow, Martha

    This report presents findings from an investigation of the perceptions, beliefs, and expectations of English-as-a-Second- Language (ESL) educators as they work toward including students with limited English proficiency (LEP) in Minnesota's High Standards. More and more states are implementing standards-based educational systems in which all…

  19. A tunable, modular approach to fluorescent protease-activated reporters.

    PubMed

    Wu, Peng; Nicholls, Samantha B; Hardy, Jeanne A

    2013-04-01

    Proteases are one of the most important and historically utilized classes of drug targets. To effectively interrogate this class of proteins, which encodes nearly 2% of the human proteome, it is necessary to develop effective and cost-efficient methods that report on their activity both in vitro and in vivo. We have developed a robust reporter of caspase proteolytic activity, called caspase-activatable green fluorescent protein (CA-GFP). The caspases play central roles in homeostatic regulation, as they execute programmed cell death, and in drug design, as caspases are involved in diseases ranging from cancer to neurodegeneration. CA-GFP is a genetically encoded dark-to-bright fluorescent reporter of caspase activity in in vitro, cell-based, and animal systems. Based on the CA-GFP platform, we developed reporters that can discriminate the activities of caspase-6 and -7, two highly related proteases. A second series of reporters, activated by human rhinovirus 3C protease, demonstrated that we could alter the specificity of the reporter by reengineering the protease recognition sequence. Finally, we took advantage of the spectrum of known fluorescent proteins to generate green, yellow, cyan, and red reporters, paving the way for multiplex protease monitoring. PMID:23561537

  20. Advanced Light Source Activity Report 1997/1998

    SciTech Connect

    Greiner, Annette

    1999-03-01

    This Lawrence Berkeley National Laboratory, Advanced Light Source (ALS) activity report for 1997/98 discusses the following topics: Introduction and Overview; Science Highlights; Facility Report; Special Events; ALS Advisory Panels 1997/98; ALS Staff 1997/98 and Facts and Figures for the year.

  1. A Self-Report Measure of Physical Activity

    ERIC Educational Resources Information Center

    Siegel, Donald

    2005-01-01

    There are multiple approaches to measuring physical activity. Among these are direct observation, electronic monitoring, direct and indirect calorimetry, and self-report instruments. Self-report instruments are the most practical and cost effective option for use with a large group. In a study by Motl, Dishman, Dowda, and Pate (2004), two groups…

  2. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements... name, address and telephone number. (4) Interstate Land Sales Registration number. (5) The date on... shall file with the Secretary an Annual Report of Activity on any initial or consolidated...

  3. 24 CFR 1710.310 - Annual report of activity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) LAND REGISTRATION Reporting Requirements... name, address and telephone number. (4) Interstate Land Sales Registration number. (5) The date on... shall file with the Secretary an Annual Report of Activity on any initial or consolidated...

  4. NASA/DOD Aerospace Knowledge Diffusion Research Project. Report 10: Summary report to phase 3 academic library respondents including frequency distributions

    NASA Technical Reports Server (NTRS)

    Pinelli, Thomas E.; Kennedy, John M.; White, Terry F.

    1991-01-01

    Phase 3 of a 4 part study was undertaken to study the use of scientific and technical information (STI) in the academic aerospace community. Phase 3 of this project used three questionnaires that were sent to three groups (i.e., faculty, librarians, and students) in the academic aerospace community. Specific attention was paid to the types of STI used and the methods in which academic users acquire STI. The responses of the academic libraries are focussed on herein. Demographic information on academic aerospace libraries is provided. Data regarding NASA interaction with academic aerospace libraries is also included, as is the survey instrument.

  5. RELAP-7 Progress Report. FY-2015 Optimization Activities Summary

    SciTech Connect

    Berry, Ray Alden; Zou, Ling; Andrs, David

    2015-09-01

    This report summarily documents the optimization activities on RELAP-7 for FY-2015. It includes the migration from the analytical stiffened gas equation of state for both the vapor and liquid phases to accurate and efficient property evaluations for both equilibrium and metastable (nonequilibrium) states using the Spline-Based Table Look-up (SBTL) method with the IAPWS-95 properties for steam and water. It also includes the initiation of realistic closure models based, where appropriate, on the U.S. Nuclear Regulatory Commission’s TRACE code. It also describes an improved entropy viscosity numerical stabilization method for the nonequilibrium two-phase flow model of RELAP-7. For ease of presentation to the reader, the nonequilibrium two-phase flow model used in RELAP-7 is briefly presented, though for detailed explanation the reader is referred to RELAP-7 Theory Manual [R.A. Berry, J.W. Peterson, H. Zhang, R.C. Martineau, H. Zhao, L. Zou, D. Andrs, “RELAP-7 Theory Manual,” Idaho National Laboratory INL/EXT-14-31366(rev. 1), February 2014].

  6. Aeronautics and Space Report of the President: 1975 Activities.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This report, submitted to the Congress by President Ford in accordance with the National Aeronautics and Space Act of 1958, summarizes the United States' space and aeronautics activities for the year 1975. Detailed summaries of the activities of the following governmental departments or agencies are provided: National Aeronautics and Space…

  7. Report of National Collegiate Alcohol Awareness Week Activities Fall 1987.

    ERIC Educational Resources Information Center

    Owens, Ann English; And Others

    This document presents a report of the education and prevention activities recognizing National Collegiate Alcohol Awareness (NCAA) Week undertaken at Central Michigan University in Mt. Pleasant, Michigan during October and early November, 1987. It begins with a brief review of the university's campus-wide programs, goals, and activities to reduce…

  8. Promoting Learning through Active Interaction. Project PLAI. Final Report.

    ERIC Educational Resources Information Center

    Chen, Deborah; Haney, Michele

    This final report describes the activities and outcomes of Promoting Learning through Active Interactions, a research-to-practice 4-year project that developed, implemented, and validated a five-module curriculum with 25 infants (ages 6-30 months) who are deaf-blind, their parents, and early interventionists. The project had the following…

  9. Active Coping Reduces Reports of Pain from Childbirth.

    ERIC Educational Resources Information Center

    Leventhal, Elaine A.; And Others

    1989-01-01

    Examined pain and negative moods during labor in relation to instructions to monitor labor contractions and LaMaze class attendance. In Study 1, pain and negative moods showed sharp decline at Stage 2 (active labor) for women who monitored and LaMaze participants; in Study 2, LaMaze participants reported decline in pain during active labor and…

  10. Worksite Health Promotion Activities. 1992 National Survey. Summary Report.

    ERIC Educational Resources Information Center

    Public Health Service (DHHS), Rockville, MD. Office of Disease Prevention and Health Promotion.

    The survey reported in this document examined worksite health promotion and disease prevention activities in 1,507 private worksites in the United States. Specificlly, the survey assessed policies, practices, services, facilities, information, and activities sponsored by employers to improve the health of their employees, and assessed health…

  11. Seed dormancy breaking diterpenoids, including novel brassicicenes J and K, from fungus Alternaria brassicicola, and their necrotic/apoptotic activities in HL-60 cells.

    PubMed

    Kenmoku, Hiromichi; Takeue, Sayaka; Oogushi, Megumi; Yagi, Yasuyuki; Sassa, Takeshi; Toyota, Masao; Asakawa, Yoshinori

    2014-03-01

    To find new metabolites similar to cotylenins and fusicoccins from the fungus Alternaria brassicicola, screening tests were carried out using the lettuce seed dormancy breaking assay. Activity-guided fractionation of the EtOAc extract from the culture using the assay afforded the isolation of two novel fusicoccane diterpenoids named brassicicenes J (1) and K (2), along with three known brassicicenes A (3), B (4), and F (5). Their structures were elucidated from extensive NMR spectral data and by comparison of these with those reported in the literature. Brassicicenes (1-5) exhibited weak to moderate seed dormancy breaking activities against lettuce seeds in the presence of abscisic acid. In addition, the necrotic/apoptotic activities of the brassicicenes (1-5), fusicoccin A (6) and cotylenin A (7) were evaluated by determining their cytotoxicity, cell viability and caspase-3/7 activation on the HL-60 cell line. Brassicicene K (2) exhibited similar cytostatic profiles to that of cotylenin A (7), and brassicicenes J (1), A (3), B (4), and F (5) exhibited necrotic activity. This is the first report of the seed dormancy breaking activity of brassicicenes in plants, and of necrotic/apoptotic activity in mammalian cells. PMID:24689212

  12. HYDRODYNAMIC MODELS FOR SLURRY BUBBLE COLUMN REACTORS. FINAL TECHNICAL REPORT ALSO INCLUDES THE QUARTERLY TECHNICAL REPORT FOR THE PERIOD 01/01/1997 - 03/31/1997.

    SciTech Connect

    DIMITRI GIDASPOW

    1997-08-15

    The objective of this study is to develop a predictive experimentally verified computational fluid dynamic (CFD) three phase model. It predicts the gas, liquid and solid hold-ups (volume fractions) and flow patterns in the industrially important bubble-coalesced (churn-turbulent) regime. The input into the model can be either particulate viscosities as measured with a Brookfield viscometer or effective restitution coefficient for particles. A combination of x-ray and {gamma}-ray densitometers was used to measure solid and liquid volume fractions. There is a fair agreement between the theory and the experiment. A CCD camera was used to measure instantaneous particle velocities. There is a good agreement between the computed time average velocities and the measurements. There is an excellent agreement between the viscosity of 800 {micro}m glass beads obtained from measurement of granular temperature (random kinetic energy of particles) and the measurement using a Brookfield viscometer. A relation between particle Reynolds stresses and granular temperature was found for developed flow. Such measurement and computations gave a restitution coefficient for a methanol catalyst to be about 0.9. A transient, two-dimensional hydrodynamic model for production of methanol from syn-gas in an Air Products/DOE LaPorte slurry bubble column reactor was developed. The model predicts downflow of catalyst at the walls and oscillatory particle and gas flow at the center, with a frequency of about 0.7 Hertz. The computed temperature variation in the rector with heat exchangers was only about 5 K, indicating good thermal management. The computed slurry height, the gas holdup and the rate of methanol production agree with LaPorte's reported data. Unlike the previous models in the literature, this model computes the gas and the particle holdups and the particle rheology. The only adjustable parameter in the model is the effective particle restitution coefficient.

  13. Report on the CEPA activities [Consorcio Educativo para la Proteccion Ambiental/Educational Consortium for Environmental Preservation] [Final report of activities from 1998 to 2002

    SciTech Connect

    Cruz, Miriam

    2003-02-01

    This report compiles the instances of scientific, educational, and institutional cooperation on environmental issues and other activities in which CEPA was engaged during the past five years, and includes several annual reports and meeting summaries. CEPA is a collaborative international consortium that brings together higher education institutions with governmental agencies, research laboratories, and private sector entities. CEPA's mission is to strengthen the technical, professional, and educational environmental infrastructure in the United States and Latin America. The CEPA program includes curriculum development, student exchange, faculty development, and creation of educational materials, joint research, and other cooperative activities. CEPA's goals are accomplished by actively working with Hispanic-serving institutions of higher education in the United States, in collaboration with institutions of higher education in Latin America and other Consortium members to deliver competitive environmental programs.

  14. High energy physics division semiannual report of research activities

    SciTech Connect

    Schoessow, P.; Moonier, P.; Talaga, R.; Wagner, R. )

    1991-08-01

    This report describes the research conducted in the High Energy Physics Division of Argonne National Laboratory during the period of January 1, 1991--June 30, 1991. Topics covered here include experimental and theoretical particle physics, advanced accelerator physics, detector development, and experimental facilities research. Lists of division publications and colloquia are included.

  15. NSLS 2006 ACTIVITY REPORT (NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 2006)

    SciTech Connect

    MILLER, L.

    2006-12-31

    and the years to follow, we need to continue to educate our elected representatives about the benefits that are provided to our society and our economy by scientific investigation including research done at DOE user facilities like the NSLS. We face another interesting challenge as the NSLS-II project progresses: the formation of scientific research teams associated with particular beamlines at the new facility. In early 2007, the final draft of the conceptual design report will be available, which will describe the projected capabilities of NSLS-II, and we can expect a workshop in mid-2007 to launch the process leading to letters of intent for beamlines. This process will include lots of discussion about access modes, as we seek ways to allow scientific and technical innovators from the user community to play significant roles at NSLS-II.

  16. NSLS 2005 ACTIVITY REPORT (NATIONAL SYNCHROTRON LIGHT SOURCE ACTIVITY REPORT 2005).

    SciTech Connect

    MILLER, L.

    2006-05-01

    In 2005, the NSLS proved itself, once again, to be a center of scientific excellence. This remarkable facility, commissioned in the early 1980s, is still attracting some of the world's best researchers in almost every scientific field, who produce more than seven hundred scientific papers every year using the NSLS. The 'Science Highlights' and 'Feature Highlights' sections of this report are just a small sampling of the many, many impressive research projects conducted at the NSLS in 2005. For example, a user group synthesized and studied zinc-oxide nanowires, which have applications in many optical and electrical devices. Another user group studied how strontium and uranium are removed from high-level radioactive waste. And in another interesting study, users deciphered the basis for antibiotic resistance. However, as always, the success of these projects depends on the performance of the facility. Again this year, the rings were in top form--reliability was 96 percent for the x-ray ring and 99 percent for the VUV-IR ring. Additionally, to keep the NSLS as productive as possible and to continue to attract users, many beamline upgrade projects were completed this year. One of the highlights of these upgrades is the new mini-gap undulator installed at beamline X25. This insertion device is providing a much brighter x-ray source for the program at X25. In the always important area of safety, several noteworthy activities took place this year. In particular, NSLS staff made a major commitment to labeling and inspecting electrical equipment. And perhaps the best news is what didn't happen--there were no reportable occurrences related to environmental, safety, or health issues in 2005, and no injuries that resulted in restricted or lost time. We all owe thanks to the dedicated NSLS staff and users who have ensured that the NSLS remains a reliable, safe, up-to-date research facility. As 2005 came to an end, I stepped down as NSLS Chairman in order to focus my primary

  17. A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

    PubMed

    Bloem, Esther; Meems, Henriet; van den Biggelaar, Maartje; Mertens, Koen; Meijer, Alexander B

    2013-09-01

    A recent chemical footprinting study in our laboratory suggested that region 1803-1818 might contribute to A2 domain retention in activated factor VIII (FVIIIa). This site has also been implicated to interact with activated factor IX (FIXa). Asn-1810 further comprises an N-linked glycan, which seems incompatible with a role of the amino acids 1803-1818 for FIXa or A2 domain binding. In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803-1810 and 1811-1818 are replaced by the corresponding residues of factor V (FV). Enzyme kinetic studies showed that only FVIII/FV 1811-1818 has a decreased apparent binding affinity for FIXa. Flow cytometry analysis indicated that fluorescent FIXa exhibits impaired complex formation with only FVIII/FV 1811-1818 on lipospheres. Site-directed mutagenesis revealed that Phe-1816 contributes to the interaction with FIXa. To evaluate FVIIIa stability, the FVIII/FV chimeras were activated by thrombin, and the decline in cofactor function was followed over time. FVIII/FV 1803-1810 and FVIII/FV 1811-1818 but not FVIII-N1810C showed a decreased FVIIIa half-life. However, when the FVIII variants were activated in presence of FIXa, only FVIII/FV 1811-1818 demonstrated an enhanced decline in cofactor function. Surface plasmon resonance analysis revealed that the FVIII variants K1813A/K1818A, E1811A, and F1816A exhibit enhanced dissociation after activation. The results together demonstrate that the glycan at 1810 is not involved in FVIII cofactor function, and that Phe-1816 of region 1811-1818 contributes to FIXa binding. Both regions 1803-1810 and 1811-1818 contribute to FVIIIa stability.

  18. A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX.

    PubMed

    Bloem, Esther; Meems, Henriet; van den Biggelaar, Maartje; Mertens, Koen; Meijer, Alexander B

    2013-09-01

    A recent chemical footprinting study in our laboratory suggested that region 1803-1818 might contribute to A2 domain retention in activated factor VIII (FVIIIa). This site has also been implicated to interact with activated factor IX (FIXa). Asn-1810 further comprises an N-linked glycan, which seems incompatible with a role of the amino acids 1803-1818 for FIXa or A2 domain binding. In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803-1810 and 1811-1818 are replaced by the corresponding residues of factor V (FV). Enzyme kinetic studies showed that only FVIII/FV 1811-1818 has a decreased apparent binding affinity for FIXa. Flow cytometry analysis indicated that fluorescent FIXa exhibits impaired complex formation with only FVIII/FV 1811-1818 on lipospheres. Site-directed mutagenesis revealed that Phe-1816 contributes to the interaction with FIXa. To evaluate FVIIIa stability, the FVIII/FV chimeras were activated by thrombin, and the decline in cofactor function was followed over time. FVIII/FV 1803-1810 and FVIII/FV 1811-1818 but not FVIII-N1810C showed a decreased FVIIIa half-life. However, when the FVIII variants were activated in presence of FIXa, only FVIII/FV 1811-1818 demonstrated an enhanced decline in cofactor function. Surface plasmon resonance analysis revealed that the FVIII variants K1813A/K1818A, E1811A, and F1816A exhibit enhanced dissociation after activation. The results together demonstrate that the glycan at 1810 is not involved in FVIII cofactor function, and that Phe-1816 of region 1811-1818 contributes to FIXa binding. Both regions 1803-1810 and 1811-1818 contribute to FVIIIa stability. PMID:23884417

  19. A3 Domain Region 1803–1818 Contributes to the Stability of Activated Factor VIII and Includes a Binding Site for Activated Factor IX

    PubMed Central

    Bloem, Esther; Meems, Henriet; van den Biggelaar, Maartje; Mertens, Koen; Meijer, Alexander B.

    2013-01-01

    A recent chemical footprinting study in our laboratory suggested that region 1803–1818 might contribute to A2 domain retention in activated factor VIII (FVIIIa). This site has also been implicated to interact with activated factor IX (FIXa). Asn-1810 further comprises an N-linked glycan, which seems incompatible with a role of the amino acids 1803–1818 for FIXa or A2 domain binding. In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803–1810 and 1811–1818 are replaced by the corresponding residues of factor V (FV). Enzyme kinetic studies showed that only FVIII/FV 1811–1818 has a decreased apparent binding affinity for FIXa. Flow cytometry analysis indicated that fluorescent FIXa exhibits impaired complex formation with only FVIII/FV 1811–1818 on lipospheres. Site-directed mutagenesis revealed that Phe-1816 contributes to the interaction with FIXa. To evaluate FVIIIa stability, the FVIII/FV chimeras were activated by thrombin, and the decline in cofactor function was followed over time. FVIII/FV 1803–1810 and FVIII/FV 1811–1818 but not FVIII-N1810C showed a decreased FVIIIa half-life. However, when the FVIII variants were activated in presence of FIXa, only FVIII/FV 1811–1818 demonstrated an enhanced decline in cofactor function. Surface plasmon resonance analysis revealed that the FVIII variants K1813A/K1818A, E1811A, and F1816A exhibit enhanced dissociation after activation. The results together demonstrate that the glycan at 1810 is not involved in FVIII cofactor function, and that Phe-1816 of region 1811–1818 contributes to FIXa binding. Both regions 1803–1810 and 1811–1818 contribute to FVIIIa stability. PMID:23884417

  20. Junior High Career Maturity Activities. Report No. 33-A-57.

    ERIC Educational Resources Information Center

    Afdahl, Anne; And Others

    The activities in this curriculum guide are designed to facilitate self-evaluation, goal setting, and educator-student planning of junior high learning experiences relating to career maturity. It is suggested that the career maturity measurement activity worksheets can be included in the student's school record and used as a reference base for…

  1. Towards a new paradigm: Activity level balanced sustainability reporting.

    PubMed

    Samudhram, Ananda; Siew, Eu-Gene; Sinnakkannu, Jothee; Yeow, Paul H P

    2016-11-01

    Technoeconomic paradigms based economic growth theories suggest that waves of technological innovations drove the economic growth of advanced economies. Widespread economic degradation and pollution is an unintended consequence of such growth. Tackling environmental and social issues at firm levels would help us to overcome such issues at macro-levels. Consequently, the Triple Bottom Line (TBL) reporting approach promotes firm level economic, environmental and social performances. Incorporating Zink's (2014) 3-pillar presentation model, this paper indicates that economic, social and environmental performances tend to be reported at firm level. All three pillars are not covered evenly at the activity levels. Thus, a loophole is identified whereby excellent environmental performance at activity levels could potentially leave poor social performance undisclosed. A refinement of the TBL paradigm, whereby all three pillars are covered at the activity level, is suggested, to enhance sustainability reporting.

  2. Towards a new paradigm: Activity level balanced sustainability reporting.

    PubMed

    Samudhram, Ananda; Siew, Eu-Gene; Sinnakkannu, Jothee; Yeow, Paul H P

    2016-11-01

    Technoeconomic paradigms based economic growth theories suggest that waves of technological innovations drove the economic growth of advanced economies. Widespread economic degradation and pollution is an unintended consequence of such growth. Tackling environmental and social issues at firm levels would help us to overcome such issues at macro-levels. Consequently, the Triple Bottom Line (TBL) reporting approach promotes firm level economic, environmental and social performances. Incorporating Zink's (2014) 3-pillar presentation model, this paper indicates that economic, social and environmental performances tend to be reported at firm level. All three pillars are not covered evenly at the activity levels. Thus, a loophole is identified whereby excellent environmental performance at activity levels could potentially leave poor social performance undisclosed. A refinement of the TBL paradigm, whereby all three pillars are covered at the activity level, is suggested, to enhance sustainability reporting. PMID:27029522

  3. Preschool Curriculum: A Child Centered Curriculum of Concepts and Activities Including All of the CDA Functional Areas--Bi-lingual and Home Activities.

    ERIC Educational Resources Information Center

    Cunningham, Dorothy, Comp.

    This preschool resource curriculum, intended for use in a Head Start center, was written to correspond with a work plan and curriculum for children 3 to 5 years of age. The units included in the curriculum guide are aimed at integrating growth experiences with the learning of basic skills. Each of the 16 units contains material related to each of…

  4. A poultry-intestinal isolate of Campylobacter jejuni produces a bacteriocin (CUV-3) active against a range of Gram positive bacterial pathogens including Clostridium perfringens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A newly isolated bacteriocin, CUV-3, produced by a poultry cecal isolate of Campylobacter jejuni strain CUV-3 had inhibitory activity against several Gram positive bacteria including Clostridium perfringens (38 strains), Staphylococcus aureus, Staph.epidermidis and Listeria monocytogenes. The pept...

  5. Including Youth with Intellectual Disabilities in Health Promotion Research: Development and Reliability of a Structured Interview to Assess the Correlates of Physical Activity among Youth

    ERIC Educational Resources Information Center

    Curtin, Carol; Bandini, Linda G.; Must, Aviva; Phillips, Sarah; Maslin, Melissa C. T.; Lo, Charmaine; Gleason, James M.; Fleming, Richard K.; Stanish, Heidi I.

    2016-01-01

    Background: The input of youth with intellectual disabilities in health promotion and health disparities research is essential for understanding their needs and preferences. Regular physical activity (PA) is vital for health and well-being, but levels are low in youth generally, including those with intellectual disabilities. Understanding the…

  6. 1994 Activity Report, National Synchrotron Light Source. Annual report, October 1, 1993-September 30, 1994

    SciTech Connect

    Rothman, E.Z.

    1995-05-01

    This report is a summary of activities carried out at the National Synchrotron Light Source during 1994. It consists of sections which summarize the work carried out in differing scientific disciplines, meetings and workshops, operations experience of the facility, projects undertaken for upgrades, administrative reports, and collections of abstracts and publications generated from work done at the facility.

  7. First report of a de novo 18q11.2 microdeletion including GATA6 associated with complex congenital heart disease and renal abnormalities.

    PubMed

    Bui, Peter H; Dorrani, Naghmeh; Wong, Derek; Perens, Gregory; Dipple, Katrina M; Quintero-Rivera, Fabiola

    2013-07-01

    Deletions of the long arm of chromosome 18 have been previously reported in many patients. Most cases involve the more distal regions of the long arm (18q21.1->qter). However, proximal interstitial deletions involving 18q11.2 are extremely rare. Here we report on a 14-month-old female with a 4.7 Mb (19,667,062-24,401,876 hg19) de novo interstitial deletion within chromosomal band 18q11.2, which includes GATA6 and 24 other RefSeq genes. The clinical features of our patient include complex congenital heart defects, a double outlet right ventricle, a subaortic ventricular septal defect, D-malposed great arteries, an atrial septal defect, a dysplastic aortic valve and patent ductus arteriosus. In addition, she had renal anomalies-a duplicated collecting system on the left and mild right hydronephrosis. These heart and renal defects are not reported in other patients with 18q proximal interstitial deletions. Heterozygous point mutations in GATA6, encoding for a zinc finger transcription factor, have been shown to cause congenital heart defects. Given the well-established biological role of GATA6 in cardiac development, a deletion of GATA6 is very likely responsible for our patient's complex congenital heart defects. This is the smallest and most proximal 18q11.2 deletion involving GATA6 that is associated with complex congenital heart disease and renal anomalies.

  8. Annual Report for 2003 Wild Horse Research and Field Activities

    USGS Publications Warehouse

    Ransom, Jason; Singer, Francis J.; Zeigenfuss, Linda C.

    2004-01-01

    This report is meant to highlight the activities of the 2003 field season, as well as to provide a general overview of the data collected. More in-depth data analysis will be conducted following the conclusion of each I phase of the research project, and in many cases will not be possible until several seasons of data are collected.

  9. Pupil Inquiry Behavior Analysis and Change Activity. Interim Project Report.

    ERIC Educational Resources Information Center

    Manion, Raymond C.

    This interim report discusses progress toward three major goals of the Pupil Inquiry Behavior Analysis and Change Activity: increased pupil inquiry, changed teacher behavior to facilitate pupil inquiry, and the development of a 32-week course of instruction to provide for these behavioral changes. Data currently available deals with the emotional…

  10. Report of the International Bureau of Education on Its Activities.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). General Conference.

    This second report by the Council of the International Bureau of Education covers the period since the close of the sixteenth session of the General Conference to 31 July 1972. It deals with the activities of the Council itself, the steps taken to develop the programme of the International Bureau of Education during the period under review, and…

  11. Measurement of factor VIII activity using one-stage clotting assay: a calibration curve has not to be systematically included in each run.

    PubMed

    Lattes, S; Appert-Flory, A; Fischer, F; Jambou, D; Toulon, P

    2011-01-01

    Coagulation factor VIII (FVIII) is usually evaluated using activated partial thromboplastin time-based one-stage clotting assays. Guidelines for clotting factor assays indicate that a calibration curve should be included each time the assay is performed. Therefore, FVIII measurement is expensive, reagent- and time-consuming. The aim of this study was to compare FVIII activities obtained using the same fully automated assay that was calibrated once (stored calibration curve) or each time the assay was performed. Unique lots of reagents were used throughout the study. We analysed 255 frozen plasma samples from patients who were prescribed FVIII measurement including treated and untreated haemophilia A patients. Twenty-six runs were performed on a 28-week period, each including four lyophilized control and at most 10 patient plasma samples. In control samples, FVIII activities were not significantly different when the assay was performed using the stored calibration curve or was daily calibrated. The same applied to FVIII activities in patient plasma samples that were not significantly different throughout the measuring range of activities [68.3% (<1-179) vs. 67.6% (<1-177), P=0.48] and no relevant bias could be demonstrated when data were compared according to Bland and Altman. These results suggest that in the studied technical conditions, performing the FVIII assay using a stored calibration curve is reliable, for at least 6 months. Therefore, as far as the same lots of reagents are used, it is not mandatory to include a calibration curve each time the FVIII assay was performed. However, this strategy has to be validated if the assay is performed in different technical conditions.

  12. Report to the Congress from The President of the United States. United States Aeronautics and Space Activities 1967.

    ERIC Educational Resources Information Center

    Johnson, Lyndon B.

    This report extensively reviews the progress of the United States in space during 1967, the tenth year of the space age. The first chapter of the report summarizes the 1967 space activities; and each of the remaining 13 chapters is devoted to reviewing the space-related activities of a particular federal agency (13 agencies included). Appendices…

  13. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    SciTech Connect

    Molnar, Denes

    2015-09-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  14. Active Sites Environmental Monitoring Program: Mid-FY 1991 report

    SciTech Connect

    Ashwood, T.L.; Wickliff, D.S.; Morrissey, C.M.

    1991-10-01

    This report summarizes the activities of the Active Sites Environmental Monitoring Program (ASEMP) from October 1990 through March 1991. The ASEMP was established in 1989 by Solid Waste Operations and the Environmental Sciences Division to provide early detection and performance monitoring at active low-level radioactive waste (LLW) disposal sites in Solid Waste Storage Area (SWSA) 6 and transuranic (TRU) waste storage sites in SWSA 5 as required by chapters II and III of US Department of Energy Order 5820.2A. Monitoring results continue to demonstrate the no LLW is being leached from the storage vaults on the tumulus pads. Loading of vaults on Tumulus II began during this reporting period and 115 vaults had been loaded by the end of March 1991.

  15. Measurement error of self-reported physical activity levels in New York City: assessment and correction.

    PubMed

    Lim, Sungwoo; Wyker, Brett; Bartley, Katherine; Eisenhower, Donna

    2015-05-01

    Because it is difficult to objectively measure population-level physical activity levels, self-reported measures have been used as a surveillance tool. However, little is known about their validity in populations living in dense urban areas. We aimed to assess the validity of self-reported physical activity data against accelerometer-based measurements among adults living in New York City and to apply a practical tool to adjust for measurement error in complex sample data using a regression calibration method. We used 2 components of data: 1) dual-frame random digit dialing telephone survey data from 3,806 adults in 2010-2011 and 2) accelerometer data from a subsample of 679 survey participants. Self-reported physical activity levels were measured using a version of the Global Physical Activity Questionnaire, whereas data on weekly moderate-equivalent minutes of activity were collected using accelerometers. Two self-reported health measures (obesity and diabetes) were included as outcomes. Participants with higher accelerometer values were more likely to underreport the actual levels. (Accelerometer values were considered to be the reference values.) After correcting for measurement errors, we found that associations between outcomes and physical activity levels were substantially deattenuated. Despite difficulties in accurately monitoring physical activity levels in dense urban areas using self-reported data, our findings show the importance of performing a well-designed validation study because it allows for understanding and correcting measurement errors.

  16. Measurement Error of Self-Reported Physical Activity Levels in New York City: Assessment and Correction

    PubMed Central

    Lim, Sungwoo; Wyker, Brett; Bartley, Katherine; Eisenhower, Donna

    2015-01-01

    Because it is difficult to objectively measure population-level physical activity levels, self-reported measures have been used as a surveillance tool. However, little is known about their validity in populations living in dense urban areas. We aimed to assess the validity of self-reported physical activity data against accelerometer-based measurements among adults living in New York City and to apply a practical tool to adjust for measurement error in complex sample data using a regression calibration method. We used 2 components of data: 1) dual-frame random digit dialing telephone survey data from 3,806 adults in 2010–2011 and 2) accelerometer data from a subsample of 679 survey participants. Self-reported physical activity levels were measured using a version of the Global Physical Activity Questionnaire, whereas data on weekly moderate-equivalent minutes of activity were collected using accelerometers. Two self-reported health measures (obesity and diabetes) were included as outcomes. Participants with higher accelerometer values were more likely to underreport the actual levels. (Accelerometer values were considered to be the reference values.) After correcting for measurement errors, we found that associations between outcomes and physical activity levels were substantially deattenuated. Despite difficulties in accurately monitoring physical activity levels in dense urban areas using self-reported data, our findings show the importance of performing a well-designed validation study because it allows for understanding and correcting measurement errors. PMID:25855646

  17. 77 FR 22068 - Proposed Information Collection (Financial Status Report) Activity: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... AFFAIRS Proposed Information Collection (Financial Status Report) Activity: Comment Request AGENCY: Office... collection of certain information by the agency. Under the Paperwork Reduction Act (PRA) of 1995, Federal... information, including each proposed extension of a currently approved collection, and allow 60 days...

  18. SUMMARY REPORT: THE CAUSES AND CONTROL OF ACTIVATED SLUDGE BULKING AND FOAMING

    EPA Science Inventory

    This 92-page Technology Transfer Summary Report provides reference material on the causes and controls of sludge bulking and foaming in activated sludge treatment that can be readily understood, and it includes sufficient detail to help plant operators control their systems. The ...

  19. Validation of the Japanese version of the Systemic Lupus Activity Questionnaire that includes physician-based assessments in a large observational cohort.

    PubMed

    Okamoto, Y; Katsumata, Y; Baba, S; Kawaguchi, Y; Gono, T; Hanaoka, M; Kawasumi, H; Yamanaka, H

    2016-04-01

    The Systemic Lupus Activity Questionnaire (SLAQ) is a patient-reported outcome for systemic lupus erythematosus (SLE). We aimed to translate it into Japanese and further investigate its validity and reliability. The English version of the SLAQ was translated into Japanese and administered to Japanese SLE patients at our university clinic. Physicians assessed disease activity using the SLE Disease Activity Index 2000 (SLEDAI-2K). The patients were prospectively followed for repeat assessment a year later. Ultimately, 255 patients participated. The patients' 10-point ratings of disease activity and SLAQ scores were significantly correlated (Spearman's ρ = 0.53). The SLAQ score was weakly correlated with the SLE Disease Activity Index 2000 (SLEDAI-2K)-nolab (omitting laboratory items; ρ = 0.18) but not with the SLEDAI-2K (ρ = 0.02). These results suggested its convergent and discriminant validity. The SLAQ demonstrated acceptable internal consistency (Cronbach's α = 0.80), and good test-retest reliability (intraclass correlation coefficient = 0.85). The effect sizes and the standardized response means of the SLAQ were as follows: clinical worsening, 0.26 and 0.31, and improvement, -0.39 and -0.41, respectively, which indicated a small but significant responsiveness. The Japanese version of the SLAQ demonstrated acceptable reliability and validity; its performance was comparable to that of the original version.

  20. Paris Observatory Analysis Center (OPAR): Report on Activities, January - December 2012

    NASA Technical Reports Server (NTRS)

    Lambert, Sebastien; Barache, Christophe

    2013-01-01

    We report on activities of the Paris Observatory VLBI Analysis Center (OPAR) for calendar year 2012 concerning the development of operational tasks, the development of our Web site, and various other activities: monitoring of the Earth's free core nutation, measuring of the post-seismic displacements of some stations, and the analysis of the recent IVS R&D sessions, including observations of quasars close to the Sun.

  1. 2015 Summary Report on Industrial and Regulatory Engagement Activities

    SciTech Connect

    Thomas, Kenneth David

    2015-09-01

    The Advanced Instrumentation, Information, and Control (II&C) Systems Technologies pathway of the Light Water Reactor Sustainability(LWRS) Program conducts a vigorous engagement strategy with the U.S. nuclear power industry, including the nuclear operating companies, major support organizations, the Nuclear Regulatory Commission (NRC), and suppliers. The goal of this engagement strategy is to develop a shared vision and common understanding across the nuclear industry of the need for II&C modernization, the performance improvement that can be obtained, and the opportunities for collaboration to enact this vision. The primary means of engaging the nuclear operating companies is through a Utility Working Group (UWG), composed of utility representatives that participate in formal meetings and bi-monthly phone calls to provide input on nuclear plant needs and priorities for II&C technologies. Two working groups were initiated during FY 2015 to provide a means for UWG members to focus on particular technologies of interest. The Outage Improvement Working Group consists of eight utilities that participate in periodic conference calls and have access to a share-point web page for acccess to project materials developed in the Advanced Outage Control Center pilot project. In the area of computer-based procedures and automated work packages, the II&C Pathway has worked with the Nuclear Information Technology Strategic Leadership (NITSL) to set up a monthly conference call with interested utility members to discuss various aspects of mobile worker technologies. Twenty one technical and project reports were delivered to the UWG during FY 2015, reflecting the work of the II&C Pathway pilot projects during the year. Distribution of these reports is one of the primary means of transferring to the nuclear industry the knowledge and experience gained during the development of advanced II&C technologies in support of LWR sustainability. Site visits to discuss pilot project

  2. Report on Active and Planned Spacecraft and Experiments. [bibliographies

    NASA Technical Reports Server (NTRS)

    Vostreys, R. W. (Editor); Horwitz, R. (Editor)

    1979-01-01

    Information concerning concerning active and planned spacecraft and experiments known to the National Space Science Data Center are included. The information contains a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and funding of individual countries as well as cooperative arrangements among different countries. Approximately 850 articles are included.

  3. Systematic review of patient-reported outcome measures (PROMs) for assessing disease activity in rheumatoid arthritis

    PubMed Central

    de Jonge, Marieke J; Fransen, Jaap; Kievit, Wietske; van Riel, Piet LCM

    2016-01-01

    Patient assessment of disease activity in rheumatoid arthritis (RA) may be useful in clinical practice, offering a patient-friendly, location independent, and a time-efficient and cost-efficient means of monitoring the disease. The objective of this study was to identify patient-reported outcome measures (PROMs) to assess disease activity in RA and to evaluate the measurement properties of these measures. Systematic literature searches were performed in the PubMed and EMBASE databases to identify articles reporting on clinimetric development or evaluation of PROM-based instruments to monitor disease activity in patients with RA. 2 reviewers independently selected articles for review and assessed their methodological quality based on the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) recommendations. A total of 424 abstracts were retrieved for review. Of these abstracts, 56 were selected for reviewing the full article and 34 articles, presenting 17 different PROMs, were finally included. Identified were: Rheumatoid Arthritis Disease Activity Index (RADAI), RADAI-5, Patient-based Disease Activity Score (PDAS) I & II, Patient-derived Disease Activity Score with 28-joint counts (Pt-DAS28), Patient-derived Simplified Disease Activity Index (Pt-SDAI), Global Arthritis Score (GAS), Patient Activity Score (PAS) I & II, Routine Assessment of Patient Index Data (RAPID) 2–5, Patient Reported Outcome-index (PRO-index) continuous (C) & majority (M), Patient Reported Outcome CLinical ARthritis Activity (PRO-CLARA). The quality of reports varied from poor to good. Typically 5 out of 10 clinimetric domains were covered in the validations of the different instruments. The quality and extent of clinimetric validation varied among PROMs of RA disease activity. The Pt-DAS28, RADAI, RADAI-5 and RAPID 3 had the strongest and most extensive validation. The measurement properties least reported and in need of more evidence were: reliability

  4. Systematic review of patient-reported outcome measures (PROMs) for assessing disease activity in rheumatoid arthritis.

    PubMed

    Hendrikx, Jos; de Jonge, Marieke J; Fransen, Jaap; Kievit, Wietske; van Riel, Piet Lcm

    2016-01-01

    Patient assessment of disease activity in rheumatoid arthritis (RA) may be useful in clinical practice, offering a patient-friendly, location independent, and a time-efficient and cost-efficient means of monitoring the disease. The objective of this study was to identify patient-reported outcome measures (PROMs) to assess disease activity in RA and to evaluate the measurement properties of these measures. Systematic literature searches were performed in the PubMed and EMBASE databases to identify articles reporting on clinimetric development or evaluation of PROM-based instruments to monitor disease activity in patients with RA. 2 reviewers independently selected articles for review and assessed their methodological quality based on the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) recommendations. A total of 424 abstracts were retrieved for review. Of these abstracts, 56 were selected for reviewing the full article and 34 articles, presenting 17 different PROMs, were finally included. Identified were: Rheumatoid Arthritis Disease Activity Index (RADAI), RADAI-5, Patient-based Disease Activity Score (PDAS) I & II, Patient-derived Disease Activity Score with 28-joint counts (Pt-DAS28), Patient-derived Simplified Disease Activity Index (Pt-SDAI), Global Arthritis Score (GAS), Patient Activity Score (PAS) I & II, Routine Assessment of Patient Index Data (RAPID) 2-5, Patient Reported Outcome-index (PRO-index) continuous (C) & majority (M), Patient Reported Outcome CLinical ARthritis Activity (PRO-CLARA). The quality of reports varied from poor to good. Typically 5 out of 10 clinimetric domains were covered in the validations of the different instruments. The quality and extent of clinimetric validation varied among PROMs of RA disease activity. The Pt-DAS28, RADAI, RADAI-5 and RAPID 3 had the strongest and most extensive validation. The measurement properties least reported and in need of more evidence were: reliability

  5. Systematic review of patient-reported outcome measures (PROMs) for assessing disease activity in rheumatoid arthritis

    PubMed Central

    de Jonge, Marieke J; Fransen, Jaap; Kievit, Wietske; van Riel, Piet LCM

    2016-01-01

    Patient assessment of disease activity in rheumatoid arthritis (RA) may be useful in clinical practice, offering a patient-friendly, location independent, and a time-efficient and cost-efficient means of monitoring the disease. The objective of this study was to identify patient-reported outcome measures (PROMs) to assess disease activity in RA and to evaluate the measurement properties of these measures. Systematic literature searches were performed in the PubMed and EMBASE databases to identify articles reporting on clinimetric development or evaluation of PROM-based instruments to monitor disease activity in patients with RA. 2 reviewers independently selected articles for review and assessed their methodological quality based on the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) recommendations. A total of 424 abstracts were retrieved for review. Of these abstracts, 56 were selected for reviewing the full article and 34 articles, presenting 17 different PROMs, were finally included. Identified were: Rheumatoid Arthritis Disease Activity Index (RADAI), RADAI-5, Patient-based Disease Activity Score (PDAS) I & II, Patient-derived Disease Activity Score with 28-joint counts (Pt-DAS28), Patient-derived Simplified Disease Activity Index (Pt-SDAI), Global Arthritis Score (GAS), Patient Activity Score (PAS) I & II, Routine Assessment of Patient Index Data (RAPID) 2–5, Patient Reported Outcome-index (PRO-index) continuous (C) & majority (M), Patient Reported Outcome CLinical ARthritis Activity (PRO-CLARA). The quality of reports varied from poor to good. Typically 5 out of 10 clinimetric domains were covered in the validations of the different instruments. The quality and extent of clinimetric validation varied among PROMs of RA disease activity. The Pt-DAS28, RADAI, RADAI-5 and RAPID 3 had the strongest and most extensive validation. The measurement properties least reported and in need of more evidence were: reliability

  6. Psychobehavioral validity of self-reported symptoms based on spontaneous physical activity.

    PubMed

    Kim, Jinhyuk; Nakamura, Toru; Kikuchi, Hiroe; Yamamoto, Yoshiharu

    2015-08-01

    A limitation of self-reports is the presence of recall biases including retrospective distortions of the respondents' experiences. To overcome this concern, ecological momentary assessment (EMA) and day reconstruction method (DRM) have recently been developed. Very recently, we reported the psychobehavioral validity of within-individual temporal variations in momentary depressive mood recorded with EMA by examining co-variant properties with spontaneous physical activity as the external criteria. However, the validity of DRM in this context has not been objectively examined yet. Therefore, in this study, we examined the psychobehavioral validity of DRM by examining temporal associations with spontaneous physical activity and then showed the difference from EMA. Twenty-two healthy undergraduates wore a watch-type computer for two consecutive days and recorded self-reported symptoms (fatigue, depressive mood, and anxious mood) by EMA. They also recorded the symptoms afterward according to the series of behavioral episodes they reconstructed (DRM) about the same days. Physical activity was also obtained using an actigraph built into the watch-type computer. Multilevel analysis showed the significant association between depressive mood recorded with EMA and local statistics (mean activity levels calculated from 60 min data length) of physical activity around EMA recordings. However, depressive mood recorded with DRM had no significant association with physical activity. As for fatigue and anxious mood, none of the methods showed significant associations with the local statistics of physical activity. These results imply that depressive mood recorded with EMA would include psychobehavioral information which cannot be captured with DRM.

  7. Aeronautics and Space Report of the President: Fiscal Year 1998 Activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    The National Aeronautics and Space Act of 1958 directed the annual Aeronautics and Space Report to include a "comprehensive description of the programmed activities and the accomplishments of all agencies of the United States in the field of aeronautics and space activities during the preceding calendar year. In recent years, the reports have been prepared on a fiscal year (FY) basis, consistent with the budgetary period now used in programs of the Federal Government. This year's report covers activities that took place from October 1, 1997, through September 30, 1998. The activities of agencies included are NASA, the Department of Defense, The Federal Aviation Administration, the Department of Commerce, the Department of the Interior, the Federal Communications Commission, the Department of Agriculture, the National Science Foundation, the Department of State, the Department of Energy, the Smithsonian Institution, the Arms Control and Disarmament Agency, the Environmental Protection Agency, and the U.S. Information Agency. Appendices cover the U.S. Government Spacecraft Record, World Record of Space Launches Successful in Attaining Earth Orbit or Beyond , Successful Launches to Orbit on U.S. Launch Vehicles, October 1, 1997-September 30, 1998, U.S. and Russian Human Space Flights, 1961-September 30, 1998, U.S. Space Launch Vehicles, Space Activities of the U.S. Government-Historical Budget Summary, Space Activities of the U.S. Government-Budget Authority in Equivalent FY 1998 Dollars, Federal Space Activities Budget, Federal Aeronautics Budget, and a glossary

  8. NASA's Microgravity Technology Report, 1996: Summary of Activities

    NASA Technical Reports Server (NTRS)

    Kierk, Isabella

    1996-01-01

    This report covers technology development and technology transfer activities within the Microgravity Science Research Programs during FY 1996. It also describes the recent major tasks under the Advanced Technology Development (ATD) Program and identifies current technology requirements. This document is consistent with NASA,s Enteprise for the Human Exploration and development of Space (HEDS) Strategic Plan. This annual update reflects changes in the Microgravity Science Research Program's new technology activities and requirements. Appendix A. FY 1996 Advanced Technology Development. Program and Project Descriptions. Appendix B. Technology Development.

  9. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Littlefield, R. G. (Editor)

    1983-01-01

    Information concerning active and planned spacecraft and experiments is included. The information covers a wide range of scientific disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represent the efforts and fundng of individual countries as well as cooperative arrangements among different countries.

  10. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Vette, J. I. (Editor); Vostreys, R. W. (Editor); Horowitz, R. (Editor)

    1978-01-01

    Information is presented, concerning active and planned spacecraft and experiments known to the National Space Science Data Center. The information included a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft projects represented the efforts and funding of individual countries as well as cooperative arrangements among different countries.

  11. Report on active and planned spacecraft and experiments

    NASA Technical Reports Server (NTRS)

    Brecht, J. J. (Editor)

    1974-01-01

    Information dealing with active and planned spacecraft and experiments known to the National Space Science Data Center (NSSDC) is presented. Included is information concerning a wide range of disciplines: astronomy, earth sciences, meteorology, planetary sciences, aeronomy, particles and fields, solar physics, life sciences, and material sciences. These spacecraft represent the efforts and funding of individual countries, as well as cooperative arrangements among different countries.

  12. High Energy Physics Division semiannual report of research activities, July 1, 1990--December 31, 1990

    SciTech Connect

    Berger, E.; Moonier, P.; May, E.; Norem, J.

    1991-02-01

    A report is presented of research and development activities conducted in the High Energy Physics Division at Argonne National Laboratory during the six month period July 1 through December 31, 1990. Analyses of data from experiments performed by members of the Division are summarized, and the status of experiments taking data and of those being prepared is reviewed. Descriptions are included of research on theoretical and phenomenological topics in particle physics. Progress reports are provided on accelerator research and development, detector research and development, and experimental facilities research. Lists are presented of publications, of colloquia and conference talks, and of significant external community activities of members of the Division.

  13. Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

    PubMed Central

    LIANG, YUN; DING, LUYIN; LI, XIAN; WANG, WEIQIN; ZHANG, XIAOHONG

    2015-01-01

    A preleukaemic phase, typified by transient pancytopenia, is a rare occurrence that usually affects children and adolescents. The present study reports the case of a 50-year-old woman with transient pancytopenia, which manifested as a fever, cough and severe anemia. Three weeks following treatment of pancytopenia with antibiotics, red blood cell and platelet transfusion, granulocyte colony-stimulating factor and human γ globulin, the condition of the patient was improved. However, 3 weeks following discharge from hospital, the patient was diagnosed with acute lymphoblastic leukemia (ALL) with complex chromosomal abnormalities, including Philadelphia chromosome and P190 breakpoint cluster region-ABL. Complete remission was achieved following one course of combination chemotherapy. In conclusion, adult ALL with pancytopenia as a preceding symptom is rare, difficult to diagnose early and easily misdiagnosed. In addition, the pathogenesis of ALL and the precipitating factors underlying this disease require further investigation. PMID:26788209

  14. Final Report: Imaging of Buried Nanoscale Optically Active Materials

    SciTech Connect

    Appelbaum, Ian

    2011-07-05

    This is a final report covering work done at University of Maryland to develop a Ballistic Electron Emission Luminescence (BEEL) microscope. This technique was intended to examine the carrier transport and photon emission in deeply buried optically-active layers and thereby provide a means for materials science to unmask the detailed consequences of experimentally controllable growth parameters, such as quantum dot size, statistics and orientation, and defect density and charge recombination pathways.

  15. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans.

    PubMed Central

    Kniazeva, Marina; Sieber, Matt; McCauley, Scott; Zhang, Kang; Watts, Jennifer L; Han, Min

    2003-01-01

    While the general steps of fatty acid (FA) biosynthesis are well understood, the individual enzymes involved in the elongation of long chain saturated and polyunsaturated FA (PUFA) are largely unknown. Recent research indicates that these enzymes might be of considerable physiological importance for human health. We use Caenorhabditis elegans to study FA elongation activities and associated abnormal phenotypes. In this article we report that the predicted C. elegans F11E6.5/ELO-2 is a functional enzyme with the FA elongation activity. It is responsible for the elongation of palmitic acid and is involved in PUFA biosynthesis. RNAi-mediated suppression of ELO-2 causes an accumulation of palmitate and an associated decrease in the PUFA fraction in triacylglycerides and phospholipid classes. This imbalance in the FA composition results in multiple phenotypic defects such as slow growth, small body size, reproductive defects, and changes in rhythmic behavior. ELO-2 cooperates with the previously reported ELO-1 in 20-carbon PUFA production, and at least one of the enzymes must function to provide normal growth and development in C. elegans. The presented data indicate that suppression of a single enzyme of the FA elongation machinery is enough to affect various organs and systems in worms. This effect resembles syndromic disorders in humans. PMID:12586704

  16. Study of Education Satellite Communication Demonstration. Fourth Quarterly Progress Report. Report of Activities and Accomplishments, April 11, 1975 to July 10, 1975.

    ERIC Educational Resources Information Center

    Syracuse Univ. Research Corp., NY. Educational Policy Research Center.

    A fourth quarterly report completes one year of the Educational Policy Research Center's (EPRC) analysis and assessment of the Education Satellite Communication demonstration. Activities and accomplishments during the period April 11, 1975-July 10, 1975 are listed and described. The report also includes cost data from the Appalachian Educational…

  17. Triennial Report 2006-2009. Commission 10: Solar Activity

    NASA Technical Reports Server (NTRS)

    Klimchuk, James A.

    2008-01-01

    Commission 10 deals with solar activity in all of its forms, ranging from the smallest nanoflares to the largest coronal mass ejections. This report reviews scientific progress over the roughly two-year period ending in the middle of 2008. This has been an exciting time in solar physics, highlighted by the launches of the Hinode and STEREO missions late in 2006. The report is reasonably comprehensive, though it is far from exhaustive. Limited space prevents the inclusion of many significant results. The report is divided into following sections: Photosphere and Chromosphere; Transition Region; Corona and Coronal Heating; Coronal Jets; Flares; Coronal Mass Ejection Initiation; Global Coronal Waves and Shocks; Coronal Dimming; The Link Between Low Coronal CME signatures and Magnetic Clouds; Coronal Mass Ejections in the Heliosphere; and Coronal Mass Ejections and Space Weather. Primary authorship is indicated at the beginning of each section.

  18. Applying the Model of Goal-Directed Behavior, Including Descriptive Norms, to Physical Activity Intentions: A Contribution to Improving the Theory of Planned Behavior.

    PubMed

    Esposito, Gabriele; van Bavel, René; Baranowski, Tom; Duch-Brown, Néstor

    2016-08-01

    The theory of planned behavior (TPB) has received its fair share of criticism lately, including calls for it to retire. We contribute to improving the theory by testing extensions such as the model of goal-directed behavior (MGDB, which adds desire and anticipated positive and negative emotions) applied to physical activity (PA) intention. We also test the inclusion of a descriptive norms construct as an addition to the subjective norms construct, also applied to PA, resulting in two additional models: TPB including descriptive norms (TPB + DN) and MGDB including descriptive norms (MGDB + DN). The study is based on an online survey of 400 young adult Internet users, previously enrolled in a subject pool. Confirmatory factor analysis (CFA) showed that TPB and TPB + DN were not fit for purpose, while MGDB and MGDB + DN were. Structural equation modelling (SEM) conducted on MGDB and MGDB + DN showed that the inclusion of descriptive norms took over the significance of injunctive norms, and increased the model's account of total variance in intention to be physically active. PMID:27229344

  19. A Drosophila Reporter for the Translational Activation of ATF4 Marks Stressed Cells during Development.

    PubMed

    Kang, Kwonyoon; Ryoo, Hyung Don; Park, Jung-Eun; Yoon, Jee-Hyun; Kang, Min-Ji

    2015-01-01

    Eukaryotic cells have evolved signaling pathways that help to restore cellular homeostasis in response to various physiological or pathological conditions. ATF4 is a transcription factor whose mRNA translation is stimulated in response to stress-activated eIF2alpha kinases. Established conditions that activate eIF2alpha phosphorylation and ATF4 translation include excessive stress in the endoplasmic reticulum (ER) and amino acid deprivation. ATF4 is activated through a unique translational activation mechanism that involves multiple upstream open reading frames (uORFs) in the 5'-untranslated region (UTR), which is conserved from yeast to mammals. Taking advantage of this, we developed a translational activation reporter of ATF4 in Drosophila, in which the dsRed reporter coding sequence was placed downstream of the Drosophila ATF4 5' UTR. This reporter remained inactive in most tissues under normal conditions, but showed dsRed expression when starved, or when challenged with conditions that imposed ER stress. In normally developing flies, a small number of cell types showed reporter expression even without exogenous stress, which included the salivary gland, gut, the male reproductive organ, and the photoreceptor cells, suggestive of inherent stress during the normal development of these cell types. These results establish a new tool to study ATF4-mediated stress response in Drosophila development and disease.

  20. Current state of evidence on 'off-label' therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria and Switzerland--a consensus report.

    PubMed

    Aringer, M; Burkhardt, H; Burmester, G R; Fischer-Betz, R; Fleck, M; Graninger, W; Hiepe, F; Jacobi, A M; Kötter, I; Lakomek, H J; Lorenz, H M; Manger, B; Schett, G; Schmidt, R E; Schneider, M; Schulze-Koops, H; Smolen, J S; Specker, C; Stoll, T; Strangfeld, A; Tony, H P; Villiger, P M; Voll, R; Witte, T; Dörner, T

    2012-04-01

    Systemic lupus erythematosus (SLE) can be a severe and potentially life-threatening disease that often represents a therapeutic challenge because of its heterogeneous organ manifestations. Only glucocorticoids, chloroquine and hydroxychloroquine, azathioprine, cyclophosphamide and very recently belimumab have been approved for SLE therapy in Germany, Austria and Switzerland. Dependence on glucocorticoids and resistance to the approved therapeutic agents, as well as substantial toxicity, are frequent. Therefore, treatment considerations will include 'off-label' use of medication approved for other indications. In this consensus approach, an effort has been undertaken to delineate the limits of the current evidence on therapeutic options for SLE organ disease, and to agree on common practice. This has been based on the best available evidence obtained by a rigorous literature review and the authors' own experience with available drugs derived under very similar health care conditions. Preparation of this consensus document included an initial meeting to agree upon the core agenda, a systematic literature review with subsequent formulation of a consensus and determination of the evidence level followed by collecting the level of agreement from the panel members. In addition to overarching principles, the panel have focused on the treatment of major SLE organ manifestations (lupus nephritis, arthritis, lung disease, neuropsychiatric and haematological manifestations, antiphospholipid syndrome and serositis). This consensus report is intended to support clinicians involved in the care of patients with difficult courses of SLE not responding to standard therapies by providing up-to-date information on the best available evidence.

  1. Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System.

    PubMed

    Wang, Zining; Ji, Jingyun; Peng, Di; Ma, Feng; Cheng, Genhong; Qin, F Xiao-Feng

    2016-05-15

    Induction of type I IFN (IFN-I) is essential for host antiviral immune responses. However, IFN-I also plays divergent roles in antibacterial immunity, persistent viral infections, autoimmune diseases, and tumorigenesis. IFN regulatory factor 3 (IRF3) is the master transcription factor that controls IFN-I production via phosphorylation-dependent dimerization in most cell types in response to viral infections and various innate stimuli by pathogen-associated molecular patterns (PAMPs). To monitor the dynamic process of IRF3 activation, we developed a novel IRF3 dimerization reporter based on bimolecular luminescence complementation (BiLC) techniques, termed the IRF3-BiLC reporter. Robust induction of luciferase activity of the IRF3-BiLC reporter was observed upon viral infection and PAMP stimulation with a broad dynamic range. Knockout of TANK-binding kinase 1, the critical upstream kinase of IRF3, as well as the mutation of serine 386, the essential phosphorylation site of IRF3, completely abolished the luciferase activity of IRF3-BiLC reporter, confirming the authenticity of IRF3 activation. Taken together, these results demonstrated that the IRF3-BiLC reporter is a highly specific, reliable, and sensitive system to measure IRF3 activity. Using this reporter system, we further observed that the temporal pattern and magnitude of IRF3 activation induced by various PAMPs are highly complex with distinct cell type-specific characteristics, and IRF3 dimerization is a direct regulatory node for IFN-α/β receptor-mediated feed-forward regulation and crosstalk with other pathways. Therefore, the IRF3-BiLC reporter has multiple potential applications, including mechanistic studies as well as the identification of novel compounds that can modulate IRF3 activation. PMID:27045107

  2. Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus.

    PubMed

    Patel, Kalyani R; Chernock, Rebecca D; Zhang, Tian R; Wang, Xiaowei; El-Mofty, Samir K; Lewis, James S

    2013-11-01

    Most oropharyngeal squamous cell carcinomas (SCC) and histologic variants harbor transcriptionally active human papillomavirus (HPV). While HPV DNA can be found in many non-oropharyngeal head and neck carcinomas, transcriptionally active HPV is rare. Verrucous carcinoma is a variant with bland cytology, warty appearance, locally destructive growth, and lack of metastasis when lacking a frankly invasive carcinoma component. Studies have shown variable rates of HPV DNA and p16 protein expression in such tumors but still have not clearly addressed if the virus has biological activity or clinical relevance in the positive cases. Department files were searched for verrucous neoplasms, including pure verrucous carcinoma, verrucous carcinoma with dysplasia or minimal invasion, and SCC arising in verrucous carcinoma (ie, having a major component of frankly invasive carcinoma). p16 immunohistochemistry, HPV DNA polymerase chain reaction (PCR) and E6/E7 mRNA reverse transcription PCR for high-risk HPV types were performed. Of the 49 cases, 6 (12.2%) showed strong (>50%) staining for p16. HPV DNA was detected in 7/49 (14.3%) cases, but only one case was positive for both p16, and HPV DNA. A total of 36 cases yielded sufficient RNA for RT-PCR (18 verrucous carcinomas, 13 atypical verrucous carcinomas, and 5 SCC arising in verrucous carcinoma). All 36 were negative, including the four p16-positive and three HPV DNA-positive tumors tested. Although a minority of verrucous carcinoma lesions are p16 and HPV DNA positive, transcriptionally active high-risk HPV is uniformly absent. These findings argue that verrucous carcinoma and its related squamous cell carcinomas are not HPV-driven tumors.

  3. Rehabilitation Services Administration Annual Report, Fiscal Year 2004: Report on Federal Activities under the "Rehabilitation Act"

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The "Rehabilitation Act of 1973," as amended (the act), provides the legislative basis for programs and activities that assist individuals with disabilities in the pursuit of gainful employment, independence, self-sufficiency and full integration into community life. This report is intended to provide a description of accomplishments and progress…

  4. Report on Federal Activities under the Rehabilitation Act. Annual Report, Fiscal Year 2001

    ERIC Educational Resources Information Center

    US Department of Education, 2005

    2005-01-01

    The Rehabilitation Act of 1973, as amended, provides the legislative basis for programs and activities that assist individuals with disabilities in the pursuit of gainful employment, independence, self-sufficiency and full integration into community life. This report is intended to provide a description of accomplishments and progress made under…

  5. Hormonal activity of polycyclic musks evaluated by reporter gene assay.

    PubMed

    Mori, Taiki; Iida, Mitsuru; Ishibashi, Hiroshi; Kohra, Shinya; Takao, Yuji; Takemasa, Takehiro; Arizono, Koji

    2007-01-01

    Synthetic musk fragrance compounds, such as polycyclic musks (PCMs), are a group of chemicals used extensively as personal care products, and can be found in the environment and the human body. PCMs, such as 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexa-methylcyclopenta-gamma-2-benzopyran (HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyltetralin (AHTN), are known to have agonistic activities toward human estrogen receptor alpha (hERalpha) and hERbeta, and have antagonistic activity toward the human androgen receptor (hAR), as shown in several reporter gene assays. However, little is known about the interaction of PCMs with the human thyroid hormone receptor (hTR), and the hormonal effects of other PCMs except for HHCB and AHTN. In this study, we focus on the interactions of six PCMs, namely, HHCB, AHTN, 4-acetyl-1,1-dimethyl-6-tert-butyl-indan (ADBI), 6-acetyl-1,1,2,3,3,5-hexamethylindan (AHMI), 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone (DPMI), and 5-acetyl-1,1,2,6-tetramethyl-3-isopropy-lindan (ATII) with hERalpha, hAR, and hTRbeta by in vitro reporter gene assay using Chinese hamster ovary cells. All the samples were found to be agonists toward hERalpha, whereas no agonistic activities of these PCMs for hAR and hTRbeta were observed. No antagonistic activities for hERalpha and hTRbeta were observed at the concentrations tested. However, several PCMs, namely, HHCB, AHTN, ATII, ADBI, and AHMI, showed dose-dependent antagonistic activities for hAR, and the IC50 values of these compounds were estimated to be 1.0 x 10(-7), 1.5 x 10(-7), 1.4 x 10(-7), 9.8 x 10(-6), and 1.4 x 10(-7) M, respectively. The results suggest that these PCMs interact with hERalpha and hAR but have no hormonal effect on hTRbeta. This is the first report on the agonistic and antagonistic activities of ATII, ADBI, AHMI, and DPMI for hERalpha and hAR as determined by in vitro reporter gene assay using stably transfected Chinese hamster ovary cells.

  6. The association between access to public transportation and self-reported active commuting.

    PubMed

    Djurhuus, Sune; Hansen, Henning S; Aadahl, Mette; Glümer, Charlotte

    2014-12-05

    Active commuting provides routine-based regular physical activity which can reduce the risk of chronic diseases. Using public transportation involves some walking or cycling to a transit stop, transfers and a walk to the end location and users of public transportation have been found to accumulate more moderate physical activity than non-users. Understanding how public transportation characteristics are associated with active transportation is thus important from a public health perspective. This study examines the associations between objective measures of access to public transportation and self-reported active commuting. Self-reported time spent either walking or cycling commuting each day and the distance to workplace were obtained for adults aged 16 to 65 in the Danish National Health Survey 2010 (n = 28,928). Access to public transportation measures were computed by combining GIS-based road network distances from home address to public transit stops an integrating their service level. Multilevel logistic regression was used to examine the association between access to public transportation measures and active commuting. Distance to bus stop, density of bus stops, and number of transport modes were all positively associated with being an active commuter and with meeting recommendations of physical activity. No significant association was found between bus services at the nearest stop and active commuting. The results highlight the importance of including detailed measurements of access to public transit in order to identify the characteristics that facilitate the use of public transportation and active commuting.

  7. Low level of self-reported physical activity in ambulatory patients new to dialysis.

    PubMed

    Johansen, Kirsten L; Chertow, Glenn M; Kutner, Nancy G; Dalrymple, Lorien S; Grimes, Barbara A; Kaysen, George A

    2010-12-01

    Physical inactivity contributes to the frailty and the decline in function that develops over time among patients with end-stage renal disease. We assessed physical activity among 1547 ambulatory patients new to dialysis in the United States Renal Data System Comprehensive Dialysis Study. We used a self-reporting Human Activity Profile that included Maximal and Adjusted Activity Scores and compared results to established norms by age and gender. Physical activity was found to be extremely low with scores for all age and gender categories below the 5th percentile of healthy individuals and 95% of patients had scores consonant with low fitness. Older age, female gender, diabetes, atherosclerotic disease, and a low level of education were associated with lower activity scores assessed by univariate and multivariable linear regression analysis. Higher serum albumin, creatinine, and lower body mass index, but not hemoglobin levels, were associated with greater physical activity. By multivariable analysis, patients on hemodialysis using a catheter reported lower levels of physical activity compared to those on peritoneal dialysis, hemodialysis using an arteriovenous fistula, or with a graft. Lower Maximal and Adjusted Activity Scores were associated with poor physical function and mental health. Hence, physical activity is distressingly low among patients new to dialysis. Thus, strategies to enhance activity in these patients should be explored.

  8. Aeronautics and space report of the president, 1974 activities

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The U.S. Government activities for 1974 in aeronautics and space are presented. Significant contributions toward the fulfillment of the nation's goals in space and aeronautics are covered, including application of space systems and technology to beneficial uses on earth, exploration of space and increase of scientific knowledge, development of improved space systems and technology, international cooperation, and advancement of civil and military aeronautics. Also in 1974, space activities in the private sector expanded to provide additional services to the public. The accomplishments are summarized.

  9. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  10. EspC, an Autotransporter Protein Secreted by Enteropathogenic Escherichia coli, Causes Apoptosis and Necrosis through Caspase and Calpain Activation, Including Direct Procaspase-3 Cleavage

    PubMed Central

    Serapio-Palacios, Antonio

    2016-01-01

    ABSTRACT Enteropathogenic Escherichia coli (EPEC) has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS), but the total number of these effectors and the overall functional relationships between these effectors during infection are poorly understood. EspC produced by EPEC cleaves fodrin, paxillin, and focal adhesion kinase (FAK), which are also cleaved by caspases and calpains during apoptosis. Here we show the role of EspC in cell death induced by EPEC. EspC is involved in EPEC-mediated cell death and induces both apoptosis and necrosis in epithelial cells. EspC induces apoptosis through the mitochondrial apoptotic pathway by provoking (i) a decrease in the expression levels of antiapoptotic protein Bcl-2, (ii) translocation of the proapoptotic protein Bax from cytosol to mitochondria, (iii) cytochrome c release from mitochondria to the cytoplasm, (iv) loss of mitochondrial membrane potential, (v) caspase-9 activation, (vi) cleavage of procaspase-3 and (vii) an increase in caspase-3 activity, (viii) PARP proteolysis, and (ix) nuclear fragmentation and an increase in the sub-G1 population. Interestingly, EspC-induced apoptosis was triggered through a dual mechanism involving both independent and dependent functions of its EspC serine protease motif, the direct cleavage of procaspase-3 being dependent on this motif. This is the first report showing a shortcut for induction of apoptosis by the catalytic activity of an EPEC protein. Furthermore, this atypical intrinsic apoptosis appeared to induce necrosis through the activation of calpain and through the increase of intracellular calcium induced by EspC. Our data indicate that EspC plays a relevant role in cell death induced by EPEC. PMID:27329750

  11. Carcinoma showing thymus-like elements of the thyroid gland: report of three cases including one case with breast cancer history.

    PubMed

    Zhang, Guanjun; Liu, Xi; Huang, Wei; Li, Xiaofeng; Johnstone, Marianne; Deng, Yuan; Ke, Yongqiang; Nunes, Quentin M; Wang, Hongyan; Wang, Yili; Zhang, Xuebin

    2015-01-01

    Carcinoma showing thymus-like elements (CASTLE) is a rare malignant tumor of the thyroid or adjacent neck soft tissues, whose histogenesis is still debated. It may resemble other primary or metastatic poorly differentiated tumors histologically and the differential diagnosis is crucial for CASTLE has a better prognosis. However, CASTLE as a second primary tumor has not been reported in the literature. We report three cases of thyroid CASTLE, including a unique tumor following breast-conserving surgery for early-stage breast invasive carcinoma. There were two female and one male. All three tumors were located in the right lobe of the thyroid, and one tumor showed extension into the surrounding soft tissue. Histologically, all tumors showed expansive growth and consisted of cords, nests or sheets of epithelial cells divided into irregularly shaped lobules by fibrous connective tissue with lymphoplasmacytic infiltration. Focal squamous differentiation resembling Hassall's corpuscles were observed. All cases stained positively for CD5, CD117, high molecular weight cytokeratin, cytokeratin, P63, carcinoembryonic antigen and epithelial membrane antigen. Positive staining for Bcl-2 in two cases and chromogranin A in one case was noted. Ki-67 expression ranged from 15 to 25%. Thyroid transcription factor and CD3 were negative. There was no evidence of recurrent or metastatic disease at following surgery. These features demonstrated CASTLE may arise from branchial pouch remnants, the thyroid solid cell nests. CASTLE is a rare entity, awareness of its occurrence as a second primary tumor is important to avoid overtreatment because it is associated with a favorable prognosis.

  12. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates

    PubMed Central

    Pfaller, Michael A.; Messer, Shawn A.; Rhomberg, Paul R.; Jones, Ronald N.; Castanheira, Mariana

    2016-01-01

    Objectives The objective of this study was to evaluate the in vitro activity of CD101, a novel echinocandin with a long serum elimination half-life, and comparator (anidulafungin and caspofungin) antifungal agents against a collection of Candida and Aspergillus spp. isolates. Methods CD101 and comparator agents were tested against 106 Candida spp. and 67 Aspergillus spp. isolates, including 27 isolates of Candida harbouring fks hotspot mutations and 12 itraconazole non-WT Aspergillus, using CLSI and EUCAST reference susceptibility broth microdilution (BMD) methods. Results Against WT and fks mutant Candida albicans, Candida glabrata and Candida tropicalis, the activity of CD101 [MIC90 = 0.06, 0.12 and 0.03 mg/L, respectively (CLSI method values)] was comparable to that of anidulafungin (MIC90 = 0.03, 0.12 and 0.03 mg/L, respectively) and caspofungin (MIC90 = 0.12, 0.25 and 0.12 mg/L, respectively). WT Candida krusei isolates were very susceptible to CD101 (MIC = 0.06 mg/L). CD101 activity (MIC50/90 = 1/2 mg/L) was comparable to that of anidulafungin (MIC50/90 = 2/2 mg/L) against Candida parapsilosis. CD101 (MIC mode = 0.06 mg/L for C. glabrata) was 2- to 4-fold more active against fks hotspot mutants than caspofungin (MIC mode = 0.5 mg/L). CD101 was active against Aspergillus fumigatus, Aspergillus terreus, Aspergillus niger and Aspergillus flavus (MEC90 range = ≤0.008–0.03 mg/L). The essential agreement between CLSI and EUCAST methods for CD101 was 92.0%–100.0% among Candida spp. and 95.0%–100.0% among Aspergillus spp. Conclusions The activity of CD101 is comparable to that of other members of the echinocandin class for the prevention and treatment of serious fungal infections. Similar results for CD101 activity versus Candida and Aspergillus spp. may be obtained with either CLSI or EUCAST BMD methods. PMID:27287236

  13. A Fluorescent Reporter of AMPK activity and Cellular Energy Stress

    PubMed Central

    Tsou, Peiling; Zheng, Bin; Hsu, Chia-Hsien; Sasaki, Atsuo T; Cantley, Lewis C.

    2011-01-01

    SUMMARY AMP-activated protein kinase (AMPK) is activated when the AMP/ATP ratio in cells is elevated due to energy stress. Here we describe a biosensor, AMPKAR, which exhibits enhanced fluorescence resonance energy transfer (FRET) in response to phosphorylation by AMPK, allowing spatio-temporal monitoring of AMPK activity in single cells. We show that this reporter responds to a variety of stimuli that are known to induce energy stress and that the response is dependent on AMPK α1 & α2 and on the upstream kinase, LKB1. Interestingly we found that AMPK activation is confined to the cytosol in response to energy stress but can be observed in both the cytosol and nucleus in response to calcium elevation. Finally, using this probe with U2OS cells in a microfluidics device, we observed a very high cell-to-cell variability in the amplitude and time course of AMPK activation and recovery in response to pulses of glucose deprivation. PMID:21459332

  14. STS-106 Crew Activity Report/Flight Day 1 Highlights

    NASA Technical Reports Server (NTRS)

    2000-01-01

    On this first day of the STS-106 Atlantis mission, the flight crew, Commander Terrence W. Wilcutt, Pilot Scott D. Altman, and Mission Specialists Daniel C. Burbank, Edward T. Lu, Richard A. Mastracchio, Yuri Ivanovich Malenchenko, and Boris V. Morukov are seen performing pre-launch activities. They are shown sitting around the breakfast table with the traditional cake, suiting-up, and riding out to the launch pad. The final inspection team is seen as they conduct their final check of the space shuttle on the launch complex. Also, included are various panoramic views of the shuttle on the pad. The crew is readied in the 'white room' for their mission. After the closing of the hatch and arm retraction, launch activities are shown including countdown, engine ignition, launch, and the separation of the Solid Rocket Boosters.

  15. STS-99 Crew Activities Report/Flight Day 1 Highlights

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Live footage shows the crew, Commander Kevin R. Kregel, Pilot Dominic L. Pudwill Gorie, and Mission Specialists Janet L. Kavandi, Janice E. Voss, Mamoru Mohri and Gerhard P.J. Thiele, seated in the dining room with the traditional cake. The crew is seen performing various pre-launch activities including suit-up, walk out to the Astro-van, and strap-in into the vehicle. Also seen are the retractions of the orbiter access arm and the gaseous oxygen mint hood, main engine start, booster ignition, liftoff, and separation of the solid rocket boosters. The Red Team (first of the dual shift crew) includes Kregel, Kavandi, and Thiele, who are shown conducting jet thruster firings, activating radar instruments, and deploying the boom (mass).

  16. STS-91 Flight Day 1 Highlights and Crew Activities Report

    NASA Technical Reports Server (NTRS)

    1998-01-01

    On this first day of the STS-91 mission, the flight crew, Cmdr. Charles J. Precourt, Pilot Dominic L. Pudwill Gorie, and Mission Specialists Franklin R. Chang-Diaz, Janet Lynn Kavandi, Wendy B. Lawrence, Valery Victorovitch Ryumin and Andrew S. W. Thomas, can be seen performing pre-launch activities such as eating the traditional breakfast, crew suit-up, and the ride out to the launch pad. Also, included are various panoramic views of the shuttle on the pad. The crew is readied in the 'white room' for their mission. After the closing of the hatch and arm retraction, launch activities are shown including countdown, engine ignition, launch, and the separation of the Solid Rocket Boosters.

  17. Active Sites Environmental Monitoring Program: FY 1991 report

    SciTech Connect

    Ashwood, T.L.; Hicks, D.S.; Morrissey, C.M.

    1992-11-01

    This report summarizes the activities of the Active Sites Environmental Monitoring Program (ASEMP) from April 1991 through September 1991. The ASEMP was established in 1989 by Solid Waste Operations (SWO) and the Environmental Sciences Division, both of Oak Ridge National Laboratory, to provide early detection and performance monitoring at active low-level (radioactive) waste (LLW) disposal sites in Solid Waste Storage Area (SWSA) 6 and transuranic (TRU) waste storage sites in SWSA 5 as required by chapters II and III of US Department of Energy Order 5820.2A. A new set of action levels was developed on the basis of a statistical analysis of background contamination. These new action levels have been used to evaluate results in this report. Results of ASEMP monitoring continue to demonstrate that no LLW (except [sup 3]H) is being leached from the storage vaults on the tumulus pads. Loading of vaults on Tumulus II, which began in early FY 1991, was >90% complete at the end of September 1991. Results of sampling of groundwater and surface waters is presented.

  18. Persistence of biologically active compounds in soil: Final report

    SciTech Connect

    Williams, S.E.

    1987-02-01

    This document describes the long-term effects of soil-applied oil shale process water on the VA fungi and Rhizobium bacteria in a native soil. Techniques include assessing the VA fungal activity at field treatment plots and using treated field soils in a bioassay to determine VA infection and Rhizobium-nodulation potentials four years after process water application. 52 refs., 32 figs., 2 tabs.

  19. Aeronautics and space report of the President, 1980 activities

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The year's achievements in the areas of communication, Earth resources, environment, space sciences, transportation, and space energy are summarized and current and planned activities in these areas at the various departments and agencies of the Federal Government are summarized. Tables show U.S. and world spacecraft records, spacecraft launchings for 1980, and scientific payload anf probes launched 1975-1980. Budget data are included.

  20. ACL Report. A Report of the Activities of the American Classical League 1977-1978.

    ERIC Educational Resources Information Center

    Lawall, Gilbert

    Five topics of interest to persons involved in classical studies are discussed in this report: (1) "A Survey of the Classical Scene" focusses on the future of classical studies in elementary and secondary schools with some mention of the situation in colleges and universities. (2) "ACL: The State of the League" includes officers, agenda and…

  1. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.

    PubMed

    Niederwieser, D; Baldomero, H; Szer, J; Gratwohl, M; Aljurf, M; Atsuta, Y; Bouzas, L F; Confer, D; Greinix, H; Horowitz, M; Iida, M; Lipton, J; Mohty, M; Novitzky, N; Nunez, J; Passweg, J; Pasquini, M C; Kodera, Y; Apperley, J; Seber, A; Gratwohl, A

    2016-06-01

    Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation. PMID:26901703

  2. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.

    PubMed

    Niederwieser, D; Baldomero, H; Szer, J; Gratwohl, M; Aljurf, M; Atsuta, Y; Bouzas, L F; Confer, D; Greinix, H; Horowitz, M; Iida, M; Lipton, J; Mohty, M; Novitzky, N; Nunez, J; Passweg, J; Pasquini, M C; Kodera, Y; Apperley, J; Seber, A; Gratwohl, A

    2016-06-01

    Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. With transplant rates ranging from 0.1 to 1001 per 10 million inhabitants, more HSCTs were registered from unrelated 16 433 donors than related 15 493 donors. Grafts were collected from peripheral blood (66%), bone marrow (24%; mainly non-malignant disorders) and cord blood (10%). Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. Growth was due to an increase in reporting teams (18%) and median transplant activity/team (from 38 to 48 HSCTs/team). An increase of 167% was noted in mismatched/haploidentical family HSCT. A Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis revealed the global perspective of WBMT to be its major strength and identified potential to be the key professional body for patients and authorities. The limited data collection remains its major weakness and threat. In conclusion, global HSCT grows over the years without plateauing (allogeneic>autologous) and at different rates in the four World Health Organization regions. Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation.

  3. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory; determination of 86 volatile organic compounds in water by gas chromatography/mass spectrometry, including detections less than reporting limits

    USGS Publications Warehouse

    Connor, Brooke F.; Rose, Donna L.; Noriega, Mary C.; Murtaugh, Lucinda K.; Abney, Sonja R.

    1998-01-01

    This report presents precision and accuracy data for volatile organic compounds (VOCs) in the nanogram-per-liter range, including aromatic hydrocarbons, reformulated fuel components, and halogenated hydrocarbons using purge and trap capillary-column gas chromatography/mass spectrometry. One-hundred-four VOCs were initially tested. Of these, 86 are suitable for determination by this method. Selected data are provided for the 18 VOCs that were not included. This method also allows for the reporting of semiquantitative results for tentatively identified VOCs not included in the list of method compounds. Method detection limits, method performance data, preservation study results, and blank results are presented. The authors describe a procedure for reporting low-concentration detections at less than the reporting limit. The nondetection value (NDV) is introduced as a statistically defined reporting limit designed to limit false positives and false negatives to less than 1 percent. Nondetections of method compounds are reported as ?less than NDV.? Positive detections measured at less than NDV are reported as estimated concentrations to alert the data user to decreased confidence in accurate quantitation. Instructions are provided for analysts to report data at less than the reporting limits. This method can support the use of either method reporting limits that censor detections at lower concentrations or the use of NDVs as reporting limits. The data-reporting strategy for providing analytical results at less than the reporting limit is a result of the increased need to identify the presence or absence of environmental contaminants in water samples at increasingly lower concentrations. Long-term method detection limits (LTMDLs) for 86 selected compounds range from 0.013 to 2.452 micrograms per liter (?g/L) and differ from standard method detection limits (MDLs) in that the LTMDLs include the long-term variance of multiple instruments, multiple operators, and multiple

  4. Wetland Biomass Production: emergent aquatic management options and evaluations. A final subcontract report. [Includes a bibliography containing 686 references on Typha from biological abstracts

    SciTech Connect

    Pratt, D.C.; Dubbe, D.R.; Garver, E.G.; Linton, P.J.

    1984-07-01

    The high yield potential and attractive chemical composition of Typha make it a particularly viable energy crop. The Minnesota research effort has demonstrated that total annual biomass yields equivalent to 30 dry tonnes/ha (13 tons/acre) are possible in planted stands. This compares with yields of total plant material between 9 and 16 dry tonnes/ha (4 to 7 tons/acre) in a typical Minnesota corn field. At least 50% of the Typha plant is comprised of a belowground rhizome system containing 40% starch and sugar. This high level of easily fermentable carbohydrate makes rhizomes an attractive feedstock for alcohol production. The aboveground portion of the plant is largely cellulose, and although it is not easily fermentable, it can be gasified or burned. This report is organized in a manner that focuses on the evaluation of the management options task. Results from stand management research performed at the University of Minnesota during 1982 and 1983 are integrated with findings from an extensive survey of relevant emergent aquatic plant research and utilization. These results and findings are then arranged in sections dealing with key steps and issues that need to be dealt with in the development of a managed emergent aquatic bio-energy system. A brief section evaluating the current status of rhizome harvesting is also included along with an indexed bibliography of the biology, ecology, and utilization of Typha which was completed with support from this SERI subcontract. 686 references, 11 figures, 17 tables.

  5. ADVANCED POWER SYSTEMS - ASH BEHAVIOR IN POWER SYSTEMS. INCLUDES THE SEMIANNUAL REPORT FOR THE PERIOD JANUARY 01, 1998 - JUNE 30, 1998.

    SciTech Connect

    1998-09-01

    The overall goal of this initiative is to develop fundamental knowledge of ash behavior in power systems for the purpose of increasing power production efficiency, reducing operation and maintenance costs, and reducing greenhouse gas emissions into the atmosphere. The specific objectives of this initiative focus primarily on ash behavior related to advanced power systems and include the following: Determine the current status of the fundamental ash interactions and deposition formation mechanisms as already reported through previous or ongoing projects at the EERC or in the literature; Determine sintering mechanisms for temperatures and particle compositions that are less well known and remain for the most part undetermined; Identify the relationship between the temperature of critical viscosity (T{sub cv}) as measured in a viscometer and the crystallization occurring in the melt; Perform a literature search on the use of heated-stage microscopy (HSM) for examining in situ ash-sintering phenomena and then validate the use of HSM in the determination of viscosity in spherical ash particles; Ascertain the formation and stability of specific mineral or amorphous phases in deposits typical of advanced power systems; and Evaluate corrosion for alloys being used in supercritical combustion systems.

  6. Stages of change for physical activity and dietary habits in persons with type 2 diabetes included in a mobile health intervention: the Norwegian study in RENEWING HEALTH

    PubMed Central

    Holmen, Heidi; Wahl, Astrid; Torbjørnsen, Astrid; Jenum, Anne Karen; Småstuen, Milada Cvancarova; Ribu, Lis

    2016-01-01

    Objective The aim of this study was to investigate stages of change for physical activity and dietary habits using baseline data from persons with type 2 diabetes included in a mobile health intervention. We examined the associations between stages of change for physical activity change and dietary change, and between stages of change for each behavior and individual characteristics, health-related quality of life, self-management, depressive symptoms, and lifestyle. Research design and methods We examined 151 persons with type 2 diabetes with an glycated hemoglobin (HbA1c) level ≥7.1%, aged ≥18 years at baseline of a randomized controlled trial, before testing a mobile app with or without health counseling. Stages of change were dichotomized into ‘pre-action’ and ‘action’. Self-management was measured using the Health Education Impact Questionnaire (heiQ) where a higher score reflects increased self-management, and health-related quality of life was measured with the Short-Form-36 (SF-36). Logistic regression modeling was performed. Results The median HbA1c level was 7.9% (7.1–12.4), 90% were overweight or obese, and 20% had ≥3 comorbidities. 58% were in the preaction stage for physical activity change and 79% in the preaction stage for dietary change. Higher scores of self-management were associated with an increased chance of being in the action stage for both dietary change and physical activity change. Higher body mass index was associated with an 8% reduced chance of being in the action stage for physical activity change (OR 0.92, 95% CI 0.86 to 0.99). Conclusions Being in the action stage was associated with higher scores of self-management, crucial for type 2 diabetes. Over half of the participants were in the preaction stage for physical activity and dietary change, and many had a high disease burden with comorbidities and overweight. Trial registration number NCT01315756. PMID:27239317

  7. Evaluating Greenhouse Gas Emissions Reporting Systems for Agricultural Waste Burning Using MODIS Active Fires

    NASA Astrophysics Data System (ADS)

    Lin, H.; Jin, Y.; Giglio, L.; Foley, J. A.; Randerson, J. T.

    2010-12-01

    Fires in agricultural ecosystems emit greenhouse gases and aerosols that influence climate on multiple spatial and temporal scales. Annex 1 countries of the United Nations Framework Convention on Climate Change (UNFCCC), many of which ratified the Kyoto Protocol, are required to report emissions of CO2, CH4 and N2O from these fires annually. We evaluated several aspects of this reporting system, including the optimality of the crops targeted by the UNFCCC globally and within Annex 1 countries and the consistency of emissions reporting among countries. We also evaluated the success of the individual countries in capturing interannual variability and long-term trends in agricultural fire activity. We combined global crop maps with Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) active fire detections. At a global scale, we recommend adding ground nuts, cocoa, cotton and oil palm, and removing potato, oats, pulse other and rye from the UNFCCC list of 14 crops. This leads to an overall increase of 6% of the active fires covered by the reporting system. Optimization led to a different recommended list for Annex 1 countries. Extending emissions reporting to all Annex 1 countries (from the current set of 19 countries) would increase the efficacy of the reporting system from 10% to 20%, and further including several non-Annex 1 countries (Argentina, Brazil, China, India, Indonesia, Thailand, Kazakhstan, Mexico and Nigeria) would capture over 58% of active fires in croplands worldwide. Analyses of interannual trends from the U.S. and Australia showed the importance of both intensity of fire use and crop production in controlling year-to-year variations in agricultural fire emissions. Remote sensing provides an efficient tool for an independent assessment of current UNFCCC emissions reporting system; and, if combined with census data, field experiments and expert opinion, has the potential for improving the robustness of the next generation inventory

  8. Advanced Light Source activity report 1996/97

    SciTech Connect

    1997-09-01

    Ten years ago, the Advanced Light Source (ALS) existed as a set of drawings, calculations, and ideas. Four years ago, it stored an electron beam for the first time. Today, the ALS has moved from those ideas and beginnings to a robust, third-generation synchrotron user facility, with eighteen beam lines in use, many more in planning or construction phases, and hundreds of users from around the world. Progress from concepts to realities is continuous as the scientific program, already strong in many diverse areas, moves in new directions to meet the needs of researchers into the next century. ALS staff members who develop and maintain the infrastructure for this research are similarly unwilling to rest on their laurels. As a result, the quality of the photon beams the authors deliver, as well as the support they provide to users, continues to improve. The ALS Activity Report is designed to share the results of these efforts in an accessible form for a broad audience. The Scientific Program section, while not comprehensive, shares the breadth, variety, and interest of recent research at the ALS. (The Compendium of User Abstracts and Technical Reports provides a more comprehensive and more technical view.) The Facility Report highlights progress in operations, ongoing accelerator research and development, and beamline instrumentation efforts. Although these Activity Report sections are separate, in practice the achievements of staff and users at the ALS are inseparable. User-staff collaboration is essential as they strive to meet the needs of the user community and to continue the ALS's success as a premier research facility.

  9. Computer Science Research Institute 2005 annual report of activities.

    SciTech Connect

    Watts, Bernadette M.; Collis, Samuel Scott; Ceballos, Deanna Rose; Womble, David Eugene

    2008-04-01

    This report summarizes the activities of the Computer Science Research Institute (CSRI) at Sandia National Laboratories during the period January 1, 2005 to December 31, 2005. During this period, the CSRI hosted 182 visitors representing 83 universities, companies and laboratories. Of these, 60 were summer students or faculty. The CSRI partially sponsored 2 workshops and also organized and was the primary host for 3 workshops. These 3 CSRI sponsored workshops had 105 participants, 78 from universities, companies and laboratories, and 27 from Sandia. Finally, the CSRI sponsored 12 long-term collaborative research projects and 3 Sabbaticals.

  10. Computer Science Research Institute 2003 annual report of activities.

    SciTech Connect

    DeLap, Barbara J.; Womble, David Eugene; Ceballos, Deanna Rose

    2006-03-01

    This report summarizes the activities of the Computer Science Research Institute (CSRI) at Sandia National Laboratories during the period January 1, 2003 to December 31, 2003. During this period the CSRI hosted 164 visitors representing 78 universities, companies and laboratories. Of these 78 were summer students or faculty members. The CSRI partially sponsored 5 workshops and also organized and was the primary host for 3 workshops. These 3 CSRI sponsored workshops had 178 participants--137 from universities, companies and laboratories, and 41 from Sandia. Finally, the CSRI sponsored 18 long-term collaborative research projects and 5 Sabbaticals.

  11. Computer Science Research Institute 2004 annual report of activities.

    SciTech Connect

    DeLap, Barbara J.; Womble, David Eugene; Ceballos, Deanna Rose

    2006-03-01

    This report summarizes the activities of the Computer Science Research Institute (CSRI) at Sandia National Laboratories during the period January 1, 2004 to December 31, 2004. During this period the CSRI hosted 166 visitors representing 81 universities, companies and laboratories. Of these 65 were summer students or faculty. The CSRI partially sponsored 2 workshops and also organized and was the primary host for 4 workshops. These 4 CSRI sponsored workshops had 140 participants--74 from universities, companies and laboratories, and 66 from Sandia. Finally, the CSRI sponsored 14 long-term collaborative research projects and 5 Sabbaticals.

  12. Status report of CPHS and neutron activities at Tsinghua University

    NASA Astrophysics Data System (ADS)

    Wang, X.; Xing, Q.; Zheng, S.; Yang, Y.; Gong, H.; Xiao, Y.; Wu, H.; Guan, X.; Du, T.

    2016-11-01

    The Compact Pulsed Hadron Source (CPHS) project that was launched in September 2009 at Tsinghua University has reached a first commissioning stage in conjunction with ongoing activities to fulfill the eventual design goal of a ˜ 1013 n/s epithermal-to-cold neutron yield for education, instrumentation development, and industrial applications. Here, we report the latest progress on the commissioning and applications of 3MeV proton and neutron beam lines in the last one and half years, and the design, fabrication, engineering of the 13MeV/16kW proton accelerator system.

  13. Activity report 1990-1992 and proceedings, volume 1

    NASA Astrophysics Data System (ADS)

    Mayer-Rosa, D.; Waniek, L.; Suhadolc, P.

    A report on the activities of the European Seismological Commission (ESC) during the period 1990-1992 together with the Proceedings of the General Assembly of the ESC are presented in two volumes. Volume 1 covers the following topics: recent strong earthquakes in Europe, regional seismicity, historical earthquakes in Europe, statistical models and methods in seismology, numerical modeling in three-dimensional media, methodology of quantification of European earthquakes and recent results, seismic noise and signal detectability, regional seismic network, and history of seismometry. One paper dealing with microseismic noise characteristics around the Kozloduy nuclear power plant has been inputted to INIS.

  14. Activity Report, 1990 - 1992 and proceedings, volume 2

    NASA Astrophysics Data System (ADS)

    Kottnauer, Ing. Pavel

    A report of the European Seismological Commission (ESC) on 1990-1992 activities and Proceedings of the General Assembly of the ESC are presented in two volumes. Volume 2 covers the following topics: study of seismic sound, seismotectonic analysis, deep seismic sounding, the three-dimensional structure of the European lithosphere-asthenosphere system, complexity in earthquake occurrence, earthquake hazard, strong and weak earthquake ground motions, macroseismology, microzonation, and applications in earthquake engineering. One paper dealing with the connection between seismicity and the CO2- (sup 222)Rn content in spring water has been inputted to INIS.

  15. FY15 Status Report on NEAMS Neutronics Activities

    SciTech Connect

    Lee, C. H.; Shemon, E. R.; Smith, M. A.; Connaway, H. M.; Aliberti, G.

    2015-09-30

    This report summarizes the current status of NEAMS activities in FY2015. The tasks this year are (1) to improve solution methods for steady-state and transient conditions, (2) to develop features and user friendliness to increase the usability and applicability of the code, (3) to improve and verify the multigroup cross section generation scheme, (4) to perform verification and validation tests of the code using SFRs and thermal reactor cores, and (5) to support early users of PROTEUS and update the user manuals.

  16. Radium equivalent activity in the light of UNSCEAR report.

    PubMed

    Tufail, Muhammad

    2012-09-01

    Radium equivalent activity (Ra ( eq )) has been in practice for the last 40 years for the assessment of radiological hazard of radioactivity in environmental materials. The in-practice model for the calculation of the Ra ( eq ) has been critically reviewed in the light of the UNSCEAR 2000 report. Annual effective dose (E) values of (232)Th and (40)K were found to be not equal to that of (226)Ra derived from the activity concentrations of these radionuclides used in the expression for the Ra ( eq ). Therefore, a modified model has been proposed for the determination of the Ra ( eq ) for outdoor external exposure to gamma rays. The relation between the E and Ra ( eq ) has been explored. It is recommended that while describing the radiological hazard of the materials containing radioactivity, there should be no need to calculate the Ra ( eq ) if the E has already been determined or vice versa.

  17. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  18. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  19. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  20. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  1. 41 CFR 102-33.260 - When we report as excess, or replace, an aircraft (including a declassified aircraft), must we...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to the Federal Aviation Interactive Reporting System (FAIRS)? 102-33.260 Section 102-33.260 Public... a declassified aircraft), must we report the change in inventory to the Federal Aviation Interactive... change in inventory to the Federal Aviation Interactive Reporting System (FAIRS). For...

  2. A Comparison of Brunt Criteria, the Non Alcoholic Fatty Liver Disease Activity Score (NAS) & a Proposed NAS-including fibrosis as Valid Diagnostic Scores for NASH

    PubMed Central

    Santiago-Rolón, Amarilys; Purcell, Dagmary; Rosado, Kathia; Toro, Doris H.

    2016-01-01

    Objective Non-alcoholic steatohepatitis (NASH) can result in cirrhosis and end stage liver disease. It is of utmost importance to differentiate NASH from simple steatosis. The aim of this study is to determine the prevalence of NASH in Latino veterans with metabolic syndrome and compare histologic grading using Brunt Criteria, the NAFLD activity score (NAS), and a proposed NAS score including fibrosis. Methods Veterans with metabolic syndrome, hepatic steatosis and elevation of ALT/AST who underwent a liver biopsy from 2004-2010 were included in this study. Biopsies were evaluated by a single blinded Hepatopathologist. Steatosis, lobular inflammation, ballooning and fibrosis were graded per specimen. Each biopsy was evaluated using Brunt criteria, NAS and NAS plus fibrosis. Results Sixty patients were included in this study, 88.3% men with a mean age of 50.4 (± 12.8). 50.0% met criteria for NASH according to the Brunt system. When classifying biopsies using NAS, only 30.0% (18/60) had a score ≥5, while when adding fibrosis, the number of patients with a score ≥5 increased to 33 (55.0%). When evaluating the predictive ability of the two scoring systems, we found that NAS including fibrosis had a higher sensitivity than NAS (86.7% vs. 40.0%) and a lower specificity (76.7% vs. 80.0%). Conclusion In our population with metabolic syndrome and altered liver function tests, about 50-55% had steatohepatitis. There were significant differences between the scoring systems. When using NAS-plus-fibrosis more patients were recognized and the sensitivity increased. Further validation studies are required to evaluate this proposed NAS scoring System. PMID:26602577

  3. Community Environmental Response Facilitation Act (CERFA) report, Pueblo Depot Activity, Colorado. Final report

    SciTech Connect

    Not Available

    1994-04-11

    This report presents the results of the Community Environmental Response Facilitation Act (CERFA) investigation conducted by Environmental Resources Management (ERM) at Pueblo Depot Activity (PUDA), a U.S. Government property selected for closure by the Base Realignment and Closure (BRAC) Commission. Under CERFA, Federal agencies are required to identify expeditiously real property that can be immediately reused and redeveloped. Satisfying this objective requires the identification of real property where no hazardous substances or petroleum products, regulated by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), were stored for one year or more, known to have been released, or disposed. Pueblo depot activity, CERFA, Base closure, BRAC.

  4. Summary of BISON Development Activities: NEAMS FY14 Report

    SciTech Connect

    Williamson, R. L.; Novascone, S. R.; Hales, J. D.; Spencer, B. W.; Liu, W.; Pastore, G.; Perez, D. M.; Gardner, R. J.; Stafford, D. S.; Gamble, K. A.

    2014-10-01

    This summary report contains an overview of work performed under the work package entitled “FY2014 NEAMS INL-Engineering Scale Fuel Performance & Interface with RPL Tools.” A first chapter identifies the specific FY-14 milestones, providing a basic description of the associated work and references to related detailed documentation. Where applicable, a representative technical result is provided. A second chapter summarizes substantial additional work including 1) efforts to improve numerical convergence and contact in BISON, 2) development of capability to simulate hydrogen behavior in Zircaloy cladding and 3) efforts to enhance collaborative work with the Halden Research Program. A final chapter briefly outlines planned future work.

  5. Stanford Synchrotron Radiation Laboratory activity report for 1987

    SciTech Connect

    Robinson, S.; Cantwell, K.

    1988-12-31

    During 1987, SSRL achieved many significant advances and reached several major milestones utilizing both SPEAR and PEP as synchrotron radiation sources as described in this report. Perhaps the following two are worthy of particular mention: (1) SPEAR reached an all time high of 4,190 delivered user-shifts during calendar year 1987, highlights of the many scientific results are given; (2) during a 12 day run in December of 1987, PEP was operated in a low emittance mode (calculated emittance 6.4 nanometer-radians) at 7.1 GeV with currents up to 33 mA. A second undulator beam line on PEP was commissioned during this run and used to record many spectra showing the extremely high brightness of the radiation. PEP is now by far the highest brightness synchrotron radiation source in the world. The report is divided into the following sections: (1) laboratory operations; (2) accelerator physics programs; (3) experimental facilities; (4) engineering division; (5) conferences and workshops; (6) SSRL organization; (7) experimental progress reports; (8) active proposals; (9) SSRL experiments and proposals by institution; and (10) SSRL publications.

  6. PREFACE: 9th International Fröhlich's Symposium: Electrodynamic Activity of Living Cells (Including Microtubule Coherent Modes and Cancer Cell Physics)

    NASA Astrophysics Data System (ADS)

    Cifra, Michal; Pokorný, Jirí; Kucera, Ondrej

    2011-12-01

    This volume contains papers presented at the International Fröhlich's Symposium entitled 'Electrodynamic Activity of Living Cells' (1-3 July 2011, Prague, Czech Republic). The Symposium was the 9th meeting devoted to physical processes in living matter organized in Prague since 1987. The hypothesis of oscillation systems in living cells featured by non-linear interaction between elastic and electrical polarization fields, non-linear interactions between the system and the heat bath leading to energy downconversion along the frequency scale, energy condensation in the lowest frequency mode and creation of a coherent state was formulated by H Fröhlich, founder of the theory of dielectric materials. He assumed that biological activity is based not only on biochemical but also on biophysical mechanisms and that their disturbances form basic links along the cancer transformation pathway. Fröhlich outlined general ideas of non-linear physical processes in biological systems. The downconversion and the elastic-polarization interactions should be connected in a unified theory and the solution based on comprehensive non-linear characteristics. Biochemical and genetic research of biological systems are highly developed and have disclosed a variety of cellular and subcellular structures, chemical reactions, molecular information transfer, and genetic code sequences - including their pathological development. Nevertheless, the cancer problem is still a big challenge. Warburg's discovery of suppressed oxidative metabolism in mitochondria in cancer cells suggested the essential role of physical mechanisms (but his discovery has remained without impact on cancer research and on the study of physical properties of biological systems for a long time). Mitochondria, the power plants of the cell, have several areas of activity-oxidative energy production is connected with the formation of a strong static electric field around them, water ordering, and liberation of non

  7. Aeronautics and space report of the President, 1983 activities

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Achievements in communication; space science; space transportation; aeronautics; and Earth resources and environment are summarized. Activities of the various Federal agencies and cooperation with NASA in these areas are described. The Presidential policy announcement on the endorsement of commercial operation of expendable launch vehicles is included. Tables show, the space activities budget; a historical budget summary, U.S. space launch vehicles; U.S. and Soviet manned spaceflights, 1961 to 1983; U.S. launched space probes, 1975 to 1983; U.S. launched scientific and applications satellites, 1978 to 1983; the U.S. spacecraft record; the world record of space launches successful in attaining Earth orbit or beyond; and successful U.S. launchings for 1983.

  8. Report of activities performed, July 1, 1980-June 30, 1981

    SciTech Connect

    Not Available

    1981-01-01

    The Numerical Data Advisory Board (NDAB) is a body within the National Research Council composed of a general board with specialized committees and panels. The objective of NDAB and its committees and panels is the improvement in quality, reliability, availability, accessibility, dissemination, utilization, and management of data. NDAB seeks to promote an appreciation of the importance of evaluated data to scientists, engineers, regulators, and others who require reliable numerical data for research and for decision making. NDAB is an interdisciplinary body with representation from physical, chemical, engineering, biological, and geological sciences. Selected sociotechnical, socioeconomic, and transient, or soft data topics are also covered. An effective path of communication with international data activities is maintained by scheduling NDAB meetings jointly with the US National Committee for CODATA, the Committee on Data for Science and Technology of the International Council for Scientific Unions (ICSU). An active government liaison relationship is maintained to facilitate input from, and discussion with branches of agencies that deal with technical data and information programs. NDAB has addressed both broad, generic cross-cutting data problems pertinent to all agencies that support R and D programs, as well as specific issues. For some of the specific topics, ad hoc meetings with subgroups of NDAB and the specific agencies requesting such discussions were held. Meetings held by NDAB for the time period covered by this report, as well as other activities, are summarized in Attachment A.

  9. STS-103 Crew Activity Report/Flight Day 1 Highlights

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Live footage of the astronauts sitting around the table with the traditional cake is presented. The crew of Discovery, Mission Commander Curtis L. Brown, Pilot Scott J. Kelly, Mission Specialists Steven L. Smith, C. Michael Foale, John M. Grunsfeld, Claude Nicollier, and Jean-Francois Clervoy are seen executing various activities including suit-up, walkout to the Astro-Van, and strap-in into the shuttle. Also presented are beautiful panoramic views of the shuttle on the pad. During this night launch, footage of the main engine start, ignition of the boosters, liftoff of Discovery, and separation of the solid rocket boosters are seen.

  10. Aeronautics and space report of the President, 1982 activities

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Achievements of the space program are summerized in the area of communication, Earth resources, environment, space sciences, transportation, aeronautics, and space energy. Space program activities of the various deprtments and agencies of the Federal Government are discussed in relation to the agencies' goals and policies. Records of U.S. and world spacecraft launchings, successful U.S. launches for 1982, U.S. launched applications and scientific satellites and space probes since 1975, U.S. and Soviet manned spaceflights since 1961, data on U.S. space launch vehicles, and budget summaries are provided. The national space policy and the aeronautical research and technology policy statements are included.

  11. Launch Deployment Assembly Extravehicular Activity Neutral Buoyancy Development Test Report

    NASA Technical Reports Server (NTRS)

    Loughead, T.

    1996-01-01

    This test evaluated the Launch Deployment Assembly (LDA) design for Extravehicular Activity (EVA) work sites (setup, igress, egress), reach and visual access, and translation required for cargo item removal. As part of the LDA design, this document describes the method and results of the LDA EVA Neutral Buoyancy Development Test to ensure that the LDA hardware support the deployment of the cargo items from the pallet. This document includes the test objectives, flight and mockup hardware description, descriptions of procedures and data collection used in the testing, and the results of the development test at the National Aeronautics and Space Administrations (NASA) Marshall Space Flight Center (MSFC) Neutral Buoyancy Simulator (NBS).

  12. DDE-MURR Status Report of Conceptual Design Activities

    SciTech Connect

    N.E. Woolstenhulme; R.B. Nielson; M.H. Sprenger; G.K. Housley

    2013-09-01

    The Design Demonstration Experiment for the University of Missouri Research Reactor (DDE-MURR) is intended to facilitate Low Enriched Uranium (LEU) conversion of the MURR by demonstrating the performance and fabrication of the LEU fuel element design through an irradiation test in a 200mm channel at the Belgium Reactor 2 (BR2). Revision 0 of this report was prepared at the end of government fiscal year 2012 when most of the resources for furthering DDE design work were expected to be postponed. Hence, the conceptual design efforts were summarized to provide the status of key objectives, notable results, and provisions for future design work. Revision 1 of this report was prepared at the end of fiscal year 2013 in order to include results from a neutronic study performed by BR2, to incorporate further details that had been achieved in the engineering sketches of the irradiation devices, and to provide an update of the DDE-MURR campaign in relation to program objectives and opportunities for its eventual irradiation. These updates were purposed to bring the DDE-MURR conceptual design to level of maturity similar to that of the other two DDE efforts (DDE-MITR and DDE-NBSR). This report demonstrates that the DDE-MURR design effort is well on the path to producing a suitable irradiation experiment, but also puts forth several recommendations in order to facilitate success of the irradiation campaign.

  13. Building Astronomy Curriculum to Include the Sight Impaired: Week long summer camp activities for Middle School Students adherent to Washington State Curriculum Standards (EALR's)

    NASA Astrophysics Data System (ADS)

    Ramien, Natalie; Loebman, S. R.; Player, V.; Larson, A.; Torcolini, N. B.; Traverse, A.

    2011-01-01

    Currently astronomy learning is heavily geared towards visual aids; however, roughly 10 million people in North America are sight impaired. Every student should have access to meaningful astronomy curriculum; an understanding of astronomy is an expectation of national and state science learning requirements. Over the last ten years, Noreen Grice has developed Braille and large print astronomy text books aimed at sight impaired learners. We build upon Grice's written work and present here a five day lesson plan that integrates 2D reading with 3D activities. Through this curriculum, students develop an intuitive understanding of astronomical distance, size, composition and lifetimes. We present five distinct lesson modules that can be taught individually or in a sequential form: the planets, our sun, stars, stellar evolution and galaxies. We have tested these modules on sight impaired students and report the results here. Overall, we find the work presented here lends itself equally well to a week long science camp geared toward middle school sight impaired taught by astronomers or as supplemental material integrated into a regular classroom science curriculum. This work was made possible by a 2007 Simple Effective Education and Dissemination (SEED) Grant For Astronomy Researchers, Astronomical Society of the Pacific through funds provided by the Planck Mission, Jet Propulsion Laboratory, California Institute of Technology.

  14. Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex.

    PubMed

    Sui, Dexin; Xu, Xinjing; Ye, Xuemei; Liu, Mengyu; Mianecki, Maxwell; Rattanasinchai, Chotirat; Buehl, Christopher; Deng, Xiexiong; Kuo, Min-Hao

    2015-01-01

    Many biomedically critical proteins are underrepresented in proteomics and biochemical studies because of the difficulty of their production in Escherichia coli. These proteins might possess posttranslational modifications vital to their functions, tend to misfold and be partitioned into bacterial inclusion bodies, or act only in a stoichiometric dimeric complex. Successful production of these proteins requires efficient interaction between these proteins and a specific "facilitator," such as a protein-modifying enzyme, a molecular chaperone, or a natural physical partner within the dimeric complex. Here we report the design and application of a protein interaction module-assisted function X (PIMAX) system that effectively overcomes these hurdles. By fusing two proteins of interest to a pair of well-studied protein-protein interaction modules, we were able to potentiate the association of these two proteins, resulting in successful production of an enzymatically active cyclin-dependent kinase complex and hyperphosphorylated tau protein, which is intimately linked to Alzheimer disease. Furthermore, using tau isoforms quantitatively phosphorylated by GSK-3β and CDK5 kinases via PIMAX, we demonstrated the hyperphosphorylation-stimulated tau oligomerization in vitro, paving the way for new Alzheimer disease drug discoveries. Vectors for PIMAX can be easily modified to meet the needs of different applications. This approach thus provides a convenient and modular suite with broad implications for proteomics and biomedical research.

  15. The Online GVP/USGS Weekly Volcanic Activity Report: Providing Timely Information About Worldwide Volcanism

    NASA Astrophysics Data System (ADS)

    Mayberry, G. C.; Guffanti, M. C.; Luhr, J. F.; Venzke, E. A.; Wunderman, R. L.

    2001-12-01

    The awesome power and intricate inner workings of volcanoes have made them a popular subject with scientists and the general public alike. About 1500 known volcanoes have been active on Earth during the Holocene, approximately 50 of which erupt per year. With so much activity occurring around the world, often in remote locations, it can be difficult to find up-to-date information about current volcanism from a reliable source. To satisfy the desire for timely volcano-related information the Smithsonian Institution and US Geological Survey combined their strengths to create the Weekly Volcanic Activity Report. The Smithsonian's Global Volcanism Program (GVP) has developed a network of correspondents while reporting worldwide volcanism for over 30 years in their monthly Bulletin of the Global Volcanism Network. The US Geological Survey's Volcano Hazards Program studies and monitors volcanoes in the United States and responds (upon invitation) to selected volcanic crises in other countries. The Weekly Volcanic Activity Report is one of the most popular sites on both organization's websites. The core of the Weekly Volcanic Activity Report is the brief summaries of current volcanic activity around the world. In addition to discussing various types of volcanism, the summaries also describe precursory activity (e.g. volcanic seismicity, deformation, and gas emissions), secondary activity (e.g. debris flows, mass wasting, and rockfalls), volcanic ash hazards to aviation, and preventative measures. The summaries are supplemented by links to definitions of technical terms found in the USGS photoglossary of volcano terms, links to information sources, and background information about reported volcanoes. The site also includes maps that highlight the location of reported volcanoes, an archive of weekly reports sorted by volcano and date, and links to commonly used acronyms. Since the Weekly Volcanic Activity Report's inception in November 2000, activity has been reported at

  16. Active Hemovigilance Significantly Improves Reporting of Acute Non-infectious Adverse Reactions to Blood Transfusion.

    PubMed

    Agnihotri, Naveen; Agnihotri, Ajju

    2016-09-01

    One of the key purposes of a hemovigilance program is to improve reporting of transfusion related adverse events and subsequent data-driven improvement in blood transfusion (BT) practices. We conducted a study over 3 years to assess the impact of healthcare worker training and an active feedback programme on reporting of adverse reactions to BTs. All hospitalized patients who required a BT were included in the study. Healthcare workers involved in BT to patients were sensitized and trained in adverse reaction reporting by conducting training sessions and meetings. All the transfused patients were 'actively' monitored for any acute adverse reaction by using a uniquely coded blood issue form. A total of 18,914 blood components transfused to 5785 different patients resulted in 61 adverse reaction episodes. This incidence of 0.32 % in our study was found to be significantly higher (p < 0.005) than that reported from the same region in the past. Red blood cell units were the most frequently transfused component and thus most commonly involved in an adverse reaction (42.6 %), however apheresis platelets had the highest chance of reaction per unit transfused (0.66 %). There was no mortality associated with the BT during the study period. An active surveillance program significantly improves reporting and management of adverse reactions to BTs. PMID:27429527

  17. In vitro activity of ceftazidime/avibactam against Gram-negative pathogens isolated from pneumonia in hospitalised patients, including ventilated patients.

    PubMed

    Flamm, Robert K; Nichols, Wright W; Sader, Helio S; Farrell, David J; Jones, Ronald N

    2016-03-01

    The activities of the novel β-lactam/non-β-lactam β-lactamase inhibitor combination ceftazidime/avibactam and comparators were evaluated against isolates from pneumonia in hospitalised patients including ventilated patients (PHP, pneumonia not designated as VABP; VABP, pneumonia in ventilated patients). Isolates were from the European-Mediterranean region (EuM), China and the USA collected in the SENTRY Antimicrobial Surveillance Program between 2009 and 2011 inclusive. A total of 2393 organisms from PHP were from the EuM, 888 from China and 3213 from the USA; from VABP patients there were 918, 97 and 692 organisms collected, respectively. Among Enterobacteriaceae from PHP, ceftazidime/avibactam MIC90 values against Escherichia coli ranged from 0.25-0.5mg/L and Klebsiella spp. MIC90 values were 0.5mg/L in each region. Among VABP isolates, MIC90 values for ceftazidime/avibactam against E. coli were 0.25mg/L; for Klebsiella spp. from VABP patients, MIC90 values were similar to those obtained against PHP isolates. The MIC of ceftazidime/avibactam was ≤8mg/L against 92-96% of Pseudomonas aeruginosa isolated from PHP patients. Isolates of P. aeruginosa from VABP patients were of lower susceptibility to all antibacterial agents (e.g. depending on region, meropenem susceptibilities were 51.2-69.4% in contrast to 68.3-76.7% among PHP patients). However, ceftazidime/avibactam inhibited 79.2-95.4% of VABP isolates at an MIC of ≤8mg/L. Acinetobacter spp. were resistant to many agents and only rates of susceptibility to colistin were >90% across all regions both for PHP and VABP isolates. Ceftazidime/avibactam was generally active against a high proportion of isolates resistant to ceftazidime from PHP and VAPB patients.

  18. Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.

    PubMed

    Kron, Miriam; Howell, C James; Adams, Ian T; Ransbottom, Michael; Christian, Diana; Ogier, Michael; Katz, David M

    2012-10-01

    Excitatory-inhibitory imbalance has been identified within specific brain microcircuits in models of Rett syndrome (RTT) and other autism spectrum disorders (ASDs). However, macrocircuit dysfunction across the RTT brain as a whole has not been defined. To approach this issue, we mapped expression of the activity-dependent, immediate-early gene product Fos in the brains of wild-type (Wt) and methyl-CpG-binding protein 2 (Mecp2)-null (Null) mice, a model of RTT, before and after the appearance of overt symptoms (3 and 6 weeks of age, respectively). At 6 weeks, Null mice exhibit significantly less Fos labeling than Wt in limbic cortices and subcortical structures, including key nodes in the default mode network. In contrast, Null mice exhibit significantly more Fos labeling than Wt in the hindbrain, most notably in cardiorespiratory regions of the nucleus tractus solitarius (nTS). Using nTS as a model, whole-cell recordings demonstrated that increased Fos expression in Nulls at 6 weeks of age is associated with synaptic hyperexcitability, including increased frequency of spontaneous and miniature EPSCs and increased amplitude of evoked EPSCs in Nulls. No such effect of genotype on Fos or synaptic function was seen at 3 weeks. In the mutant forebrain, reduced Fos expression, as well as abnormal sensorimotor function, were reversed by the NMDA receptor antagonist ketamine. In light of recent findings that the default mode network is hypoactive in autism, our data raise the possibility that hypofunction within this meta-circuit is a shared feature of RTT and other ASDs and is reversible. PMID:23035095

  19. Impurity profile tracking for active pharmaceutical ingredients: case reports.

    PubMed

    Zhou, Lili; Mao, Bing; Reamer, Robert; Novak, Tom; Ge, Zhihong

    2007-06-28

    Tracking the impurity profile of an active pharmaceutical ingredient (API) is a very important task for all stages of drug development. A systematic approach for tracking impurity profile of API is described. Various real pharmaceutical applications are presented through successful examples of impurity profile tracking for three different novel APIs. These include MK-0969, an M3 antagonist; MK-0677, an oral-active growth hormone secretagogue and API-A, a cathepsin K inhibitor. A general strategy including selection of a reversed phase high performance liquid chromatographic (RP-HPLC) impurity profile method based on screening various stationary phases and changing the pH of the mobile phase and elucidation of impurity structures through the utilization of LC-MS, preparative-LC and NMR is demonstrated. A series of studies were conducted on the peak purity check by using the LC-UV diode-array and LC-MS detections. The advantages and disadvantages of each technique in the evaluation of peak purity are discussed. PMID:17142001

  20. Research and development activities on Three Mile Island Unit Two. Annual report for 1985

    SciTech Connect

    Not Available

    1986-04-01

    The year 1985 was significant in the cleanup of Three Mile Island Unit 2 (TMI-2). Major milestones in the project included lifting the plenum assembly from the reactor vessel and the start of operations to remove the damaged fuel from the reactor. This report summarizes these milestones and other TMI-2 related cleanup, research, and development activities. Other major topics include the following: waste immobilization and management; fuel shipping cask delivery and testing; sample acquisition and evaluation; and decontamination and dose reduction. 26 figs.

  1. Behavioral approach system activity and self-reported somatic symptoms in fibromyalgia: an exploratory study.

    PubMed

    Becerra-García, Juan A; Robles Jurado, Manuel J

    2014-01-01

    The first objective was to investigate the behavioural activity in the systems of Gray's theory; these are the Behavioural Inhibition System (BIS) and Behavioural Approach System (BAS), in fibromyalgia (FM) patients. The second aim was to assess in FM patients whether there is an association between BIS or BAS with self-reported somatic symptoms. Twenty FM patients and 20 healthy controls completed questionnaire measures of BIS and BAS activity (Sensitivity to Punishment and Sensitivity to Reward Questionnaire), self-reported somatic symptoms (Somatic Symptoms Scale Revised), positive and negative affect (Positive and Negative Affect Schedule) and health status (EuroQoL Visual Analogue Scale). The results showed that FM patients had lower Sensitivity to Reward (SR) scores than controls. The SR score correlated with different somatic symptoms groups. The partial correlation (controlling for other variables measured) showed that the SR score correlated specifically with musculoskeletal symptoms. Furthermore, in regression analysis, SR score significantly predicted musculoskeletal symptoms, after controlling for other variables measured in this study. Our findings suggest that FM patients show BAS hypoactivity. This BAS activity in FM is similar to patients with depression, where a lower BAS functioning has also been found. The BAS activity predicts the musculoskeletal self-reported symptoms in FM better than other measures included in this study. Although this is a preliminary study, it suggests the importance of BAS activity in FM.

  2. Behavioral approach system activity and self-reported somatic symptoms in fibromyalgia: an exploratory study.

    PubMed

    Becerra-García, Juan A; Robles Jurado, Manuel J

    2014-01-01

    The first objective was to investigate the behavioural activity in the systems of Gray's theory; these are the Behavioural Inhibition System (BIS) and Behavioural Approach System (BAS), in fibromyalgia (FM) patients. The second aim was to assess in FM patients whether there is an association between BIS or BAS with self-reported somatic symptoms. Twenty FM patients and 20 healthy controls completed questionnaire measures of BIS and BAS activity (Sensitivity to Punishment and Sensitivity to Reward Questionnaire), self-reported somatic symptoms (Somatic Symptoms Scale Revised), positive and negative affect (Positive and Negative Affect Schedule) and health status (EuroQoL Visual Analogue Scale). The results showed that FM patients had lower Sensitivity to Reward (SR) scores than controls. The SR score correlated with different somatic symptoms groups. The partial correlation (controlling for other variables measured) showed that the SR score correlated specifically with musculoskeletal symptoms. Furthermore, in regression analysis, SR score significantly predicted musculoskeletal symptoms, after controlling for other variables measured in this study. Our findings suggest that FM patients show BAS hypoactivity. This BAS activity in FM is similar to patients with depression, where a lower BAS functioning has also been found. The BAS activity predicts the musculoskeletal self-reported symptoms in FM better than other measures included in this study. Although this is a preliminary study, it suggests the importance of BAS activity in FM. PMID:24472271

  3. Additional guidance for including nuclear safety equivalency in the Canister Storage Building and Cold Vacuum Drying Facility final safety analysis report

    SciTech Connect

    Garvin, L.J.

    1997-05-20

    This document provides guidance for the production of safety analysis reports that must meet both DOE Order 5480.23 and STD 3009, and be in compliance with the DOE regulatory policy that imposes certain NRC requirements.

  4. [Applying a creative art activity in care: report on an experience with a newly admitted resident].

    PubMed

    Wen, Hsin-Sing; Wu, Hung-Lan; Lee, Hsien-Ju

    2014-10-01

    Doing creative art has been shown to increase activity, reduce anxiety, promote confidence and self-esteem, increase sense of achievement, and facilitate participation in life activities in the elderly. This article describes a nursing experience that used creative art activities to help an elderly resident adjust to the environment and living conditions at a long-term care facility. During the care period from October 20th to December 16th, 2012, we evaluated the health problems of the resident, which included anxiety, loneliness, and low self-esteem. The creative art activity was a 30-minute intervention held 1~2 times per week for a total of 13 sessions. This article reports on the positive effects of this intervention on reducing the resident's negative emotions such as anxiety and loneliness and, in the long run, promoting self-esteem and sense of achievement.

  5. Active sites in char gasification: Final technical report

    SciTech Connect

    Wojtowicz, M.; Lilly, W.D.; Perkins, M.T.; Hradil, G.; Calo, J.M.; Suuberg, E.M.

    1987-09-01

    Among the key variables in the design of gasifiers and combustors is the reactivity of the chars which must be gasified or combusted. Significant loss of unburned char is unacceptable in virtually any process; the provision of sufficient residence time for complete conversion is essential. A very wide range of reactivities are observed, depending upon the nature of the char in a process. The current work focuses on furthering the understanding of gasification reactivities of chars. It has been well established that the reactivity of char to gasification generally depends upon three principal factors: (1) the concentration of ''active sites'' in the char; (2) mass transfer within the char; and (3) the type and concentration of catalytic impurities in the char. The present study primarily addresses the first factor. The subject of this research is the origin, nature, and fate of active sites in chars derived from parent hydrocarbons with coal-like structure. The nature and number of the active sites and their reactivity towards oxygen are examined in ''model'' chars derived from phenol-formaldehyde type resins. How the active sites are lost by the process of thermal annealing during heat treatment of chars are studied, and actual rate for the annealing process is derived. Since intrinsic char reactivities are of primary interest in the present study, a fair amount of attention was given to the model char synthesis and handling so that the effect of catalytic impurities and oxygen-containing functional groups in the chemical structure of the material were minimized, if not completely eliminated. The project would not be considered complete without comparing characteristic features of synthetic chars with kinetic behavior exhibited by natural chars, including coal chars.

  6. Status report on the survey and alignment activities at Fermilab

    SciTech Connect

    Oshinowo, Babatunde O'Sheg; /Fermilab

    2004-10-01

    The surveying and alignment activities at Fermilab are the responsibility of the Alignment and Metrology Group. The Group supports and interacts with physicists and engineers working on any particular project, from the facility construction phase to the installation and final alignment of components in the beam line. One of the goals of the Alignment and Metrology Group is to upgrade the old survey networks in the tunnel using modern surveying technology, such as the Laser Tracker for tunnel networks and GPS for the surface networks. According to the job needs, all surveys are done with Laser Trackers and/or Videogrammetry (V-STARS) systems for spatial coordinates; optical and electronic levels are used for elevations, Gyro-Theodolite for azimuths, Mekometer for distances and GPS for baseline vectors. The group has recently purchased two new API Laser Trackers, one INCA3 camera for the V-Stars, and one DNA03 digital level. This report presents the projects and major activities of the Alignment and Metrology Group at Fermilab during the period of 2000 to 2004. It focuses on the most important current projects, especially those that have to be completed during the currently scheduled three-month shutdown period. Future projects, in addition to the status of the current projects, are also presented.

  7. Standardizing accelerometer-based activity monitor calibration and output reporting.

    PubMed

    Coolbaugh, Crystal L; Hawkins, David A

    2014-08-01

    Wearable accelerometer-based activity monitors (AMs) are used to estimate energy expenditure and ground reaction forces in free-living environments, but a lack of standardized calibration and data reporting methods limits their utility. The objectives of this study were to (1) design an inexpensive and easily reproducible AM testing system, (2) develop a standardized calibration method for accelerometer-based AMs, and (3) evaluate the utility of the system and accuracy of the calibration method. A centrifuge-type device was constructed to apply known accelerations (0-8g) to each sensitive axis of 30 custom and two commercial AMs. Accelerometer data were recorded and matrix algebra and a least squares solution were then used to determine a calibration matrix for the custom AMs to convert raw accelerometer output to units of g's. Accuracy was tested by comparing applied and calculated accelerations for custom and commercial AMs. AMs were accurate to within 4% of applied accelerations. The relatively inexpensive AM testing system (< $100) and calibration method has the potential to improve the sharing of AM data, the ability to compare data from different studies, and the accuracy of AM-based models to estimate various physiological and biomechanical quantities of interest in field-based assessments of physical activity.

  8. Activities report of the Centro Studi E Laboratori Telecomunicazioni: Reports and balances

    NASA Astrophysics Data System (ADS)

    1991-05-01

    The CSELT management report on structure and activities covers public and ISDN (Integrated Services Digital Network) networks, intelligence and service networks, mobile services, management of OSS (Operation Support Systems) and networks, high-speed networks and services, optical networks and systems, radio points and satellites, and duality and conformity tests. Management progress, investments, personnel, participation in European projects, and collaboration with Italian universities are outlined. An analysis of income results and of the patrimonial and financial situations is given. Balances at 31 Dec. 1990 are shown.

  9. 1993 annual report of hazardous waste activities for the Oak Ridge K-25 site

    SciTech Connect

    Not Available

    1994-02-01

    This report is a detailed listing of all of the Hazardous Waste activities occurring at Martin Marietta`s K-25 site. Contained herein are hazardous waste notification forms, waste stream reports, generator fee forms and various TSDR reports.

  10. 20 CFR 10.526 - Must the employee report volunteer activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Must the employee report volunteer activities....526 Must the employee report volunteer activities? An employee who is receiving compensation for partial or total disability is periodically required to report volunteer activity or any other kind...

  11. 20 CFR 10.526 - Must the employee report volunteer activities?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Must the employee report volunteer activities....526 Must the employee report volunteer activities? An employee who is receiving compensation for partial or total disability is periodically required to report volunteer activity or any other kind...

  12. 20 CFR 10.526 - Must the employee report volunteer activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Must the employee report volunteer activities....526 Must the employee report volunteer activities? An employee who is receiving compensation for partial or total disability is periodically required to report volunteer activity or any other kind...

  13. 20 CFR 10.526 - Must the employee report volunteer activities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Must the employee report volunteer activities....526 Must the employee report volunteer activities? An employee who is receiving compensation for partial or total disability is periodically required to report volunteer activity or any other kind...

  14. 20 CFR 10.526 - Must the employee report volunteer activities?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Must the employee report volunteer activities....526 Must the employee report volunteer activities? An employee who is receiving compensation for partial or total disability is periodically required to report volunteer activity or any other kind...

  15. 77 FR 75198 - Standard Format and Content for Post-Shutdown Decommissioning Activities Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... COMMISSION Standard Format and Content for Post-Shutdown Decommissioning Activities Report AGENCY: Nuclear... Format and Content for Post-shutdown Decommissioning Activities Report.'' This guide describes a method...) 1.185, ``Standard Format and Content for Post-shutdown Decommissioning Activities Report,''...

  16. 34 CFR 303.15 - Include; including.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include; including. 303.15 Section 303.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS...

  17. STS-106 Crew Activities Report/Flight Day 07 Highlights

    NASA Technical Reports Server (NTRS)

    2000-01-01

    On this seventh day of the STS-106 Atlantis mission, the flight crew, Commander Commander Terrence W. Wilcutt, Pilot Scott D. Altman, and Mission Specialists Daniel C. Burbank, Edward T. Lu, Richard A. Mastracchio, Yuri Ivanovich Malenchenko, and Boris V. Morukov are seen participating in several outfitting activities. Burbank and Morukov remove and replace a fourth battery in Zarya. Lu and Malenchenko finish installing the third and final battery and other electrical equipment inside the Zvezda Service Module. While Altman and Wilcutt perform a series of jet firings, Altman is shown as he narrates a tour of the Zvezda Service Module. Scenes also include Lu and Malenchenko unpacking the Russian-made Orlan space suits, Burbank and Wilcutt participating in an interview, and a beautiful night shot of the International Space Station (ISS) and Atlantis complex above the Earth.

  18. Kinetics of Hydrogen Radical Reactions with Toluene Including Chemical Activation Theory Employing System-Specific Quantum RRK Theory Calibrated by Variational Transition State Theory.

    PubMed

    Bao, Junwei Lucas; Zheng, Jingjing; Truhlar, Donald G

    2016-03-01

    Pressure-dependent reactions are ubiquitous in combustion and atmospheric chemistry. We employ a new calibration procedure for quantum Rice-Ramsperger-Kassel (QRRK) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff effect of a radical association with an aromatic ring. The new theoretical framework is applied to the reaction of H with toluene, which is a prototypical reaction in the combustion chemistry of aromatic hydrocarbons present in most fuels. Both the hydrogen abstraction reactions and the hydrogen addition reactions are calculated. Our system-specific (SS) QRRK approach is adjusted with SS parameters to agree with multistructural canonical variational transition state theory with multidimensional tunneling (MS-CVT/SCT) at the high-pressure limit. The new method avoids the need for the usual empirical estimations of the QRRK parameters, and it eliminates the need for variational transition state theory calculations as a function of energy, although in this first application we do validate the falloff curves by comparing SS-QRRK results without tunneling to multistructural microcanonical variational transition state theory (MS-μVT) rate constants without tunneling. At low temperatures, the two approaches agree well with each other, but at high temperatures, SS-QRRK tends to overestimate falloff slightly. We also show that the variational effect is important in computing the energy-resolved rate constants. Multiple-structure anharmonicity, torsional-potential anharmonicity, and high-frequency-mode vibrational anharmonicity are all included in the rate computations, and torsional anharmonicity effects on the density of states are investigated. Branching fractions, which are both temperature- and pressure-dependent (and for which only limited data is available from experiment), are predicted as a function of pressure. PMID:26841076

  19. Kinetics of Hydrogen Radical Reactions with Toluene Including Chemical Activation Theory Employing System-Specific Quantum RRK Theory Calibrated by Variational Transition State Theory.

    PubMed

    Bao, Junwei Lucas; Zheng, Jingjing; Truhlar, Donald G

    2016-03-01

    Pressure-dependent reactions are ubiquitous in combustion and atmospheric chemistry. We employ a new calibration procedure for quantum Rice-Ramsperger-Kassel (QRRK) unimolecular rate theory within a chemical activation mechanism to calculate the pressure-falloff effect of a radical association with an aromatic ring. The new theoretical framework is applied to the reaction of H with toluene, which is a prototypical reaction in the combustion chemistry of aromatic hydrocarbons present in most fuels. Both the hydrogen abstraction reactions and the hydrogen addition reactions are calculated. Our system-specific (SS) QRRK approach is adjusted with SS parameters to agree with multistructural canonical variational transition state theory with multidimensional tunneling (MS-CVT/SCT) at the high-pressure limit. The new method avoids the need for the usual empirical estimations of the QRRK parameters, and it eliminates the need for variational transition state theory calculations as a function of energy, although in this first application we do validate the falloff curves by comparing SS-QRRK results without tunneling to multistructural microcanonical variational transition state theory (MS-μVT) rate constants without tunneling. At low temperatures, the two approaches agree well with each other, but at high temperatures, SS-QRRK tends to overestimate falloff slightly. We also show that the variational effect is important in computing the energy-resolved rate constants. Multiple-structure anharmonicity, torsional-potential anharmonicity, and high-frequency-mode vibrational anharmonicity are all included in the rate computations, and torsional anharmonicity effects on the density of states are investigated. Branching fractions, which are both temperature- and pressure-dependent (and for which only limited data is available from experiment), are predicted as a function of pressure.

  20. Studies on medically important flies in Thailand. III. Report of species belonging to the genus Musca Linné, including the taxonomic key (Diptera: Muscidae).

    PubMed

    Tumrasvin, W; Shinonaga, S

    1977-09-01

    Twenty species belonging to the genus Musca Linné are reported from Thailand with taxonomic key. This study is based on the specimens available in the authors' collection and 8 species are the new records from this country. The newly recorded species are Musca interrupta pilifacies, M. lucens, M. fasciata, M. pattoni, M. planiceps, M. xanthomelas, M. bezzii and M. convexifrons.

  1. Preparation of Trainers of Volunteer Parent Service Providers (Including Parents) for Vermont's School-Age Learners with Severe Developmental Disabilities. Final Report.

    ERIC Educational Resources Information Center

    Seaver-Reid, Mary Ellen; And Others

    The report describes Volunteers for Families (VFF), a 3-year project to develop a statewide (Vermont) network of trained volunteers to advocate for and to provide and coordinate services to, families of school-age learners (ages 3-21) with severe developmental disabilities. A three-phase process for establishing a VFF program is outlined,…

  2. Recent Reform and Perspectives in Higher Education: Report of the Seminar Including a Range of Countries from Asia-Pacific and Europe.

    ERIC Educational Resources Information Center

    National Inst. for Educational Research, Tokyo (Japan).

    This report describes a 1998 seminar held to review the situation of higher education reform in Asia and the Pacific region, as well as in some Western nations, and to identify common issues and priorities, and then develop a collaborative framework for addressing these issues and setting priorities. Seventeen participants from 16 countries…

  3. Intergovernmental Oceanographic Commission Eleventh Session of the Assembly, Including Resolutions from the Tenth and Eleventh Sessions of the Executive Council, Paris, 15 October - 3 November 1979. Summary Report.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Intergovernmental Oceanographic Commission.

    The Intergovernmental Oceanographic Commission (IOC) functions within the United Nations Educational, Scientific, and Cultural Organization (Unesco) to promote scientific investigation into the nature and resources of the world's oceans. Summarized in this report are discussions that took place in both preparatory meetings and plenary sessions of…

  4. General aviation activity and avionics survey. Annual report for CY81

    SciTech Connect

    Schwenk, J.C.; Carter, P.W.

    1982-12-01

    This report presents the results and a description of the 1981 General Aviation Activity and Avionics Survey. The survey was conducted during 1982 by the FAA to obtain information on the activity and avionics of the United States registered general aviation aircraft fleet, the dominant component of civil aviation in the U.S. The survey was based on a statistically selected sample of about 8.9 percent of the general aviation fleet and obtained a response rate of 61 percent. Survey results are based upon response but are expanded upward to represent the total population. Survey results revealed that during 1981 an estimated 40.7 million hours of flying time were logged by the 213,226 active general aviation aircraft in the U.S. fleet, yielding a mean annual flight time per aircraft of 188.1 hours. The active aircraft represented about 83 percent of the registered general aviation fleet. The report contains breakdowns of these and other statistics by manufacturer/model group, aircraft type, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, avionics, and engine hours estimates. In addition, tables are included for detailed analysis of the avionics capabilities of GA fleet.

  5. Peptide reporters of kinase activity in whole cell lysates

    PubMed Central

    Wu, Ding; Sylvester, Juliesta E.; Parker, Laurie L.; Zhou, Guangchang; Kron, Stephen J.

    2010-01-01

    Kinase assays are used to screen for small-molecule inhibitors that may show promise as targeted pharmaceutical therapies. Using cell lysates instead of purified kinases provides a more accurate estimate of inhibitor sensitivity and selectivity in a biological setting. This review summarizes the range of homogeneous (solution-phase) and heterogeneous (solid-supported) formats available for using peptide substrates to monitor kinase activities in cell lysates. With a focus on heterogeneous kinase assays, the peptide substrate Abltide is used as a model to optimize presentation geometries and the modular arrangement of short sequences for kinase recognition. We present results from peptides immobilized on two- and three-dimensional surfaces such as hydrogels on 96-well plates and glass slides, and fluorescent Luminex beads. We discuss methods to increase assay sensitivity using chemifluorescent ELISAs, antibody-based recognition, and label-free mass spectrometry. Monitoring the activity of specific kinases in cell lysates presents challenges that can be overcome by manipulating peptide substrates to optimize assay conditions. In particular, signal-to-background ratios were improved by 1) adding long branched hydrophilic linkers between the substrate and the surface, 2) changing the orientation of peptides relative to the surface, and 3) including peptide ligands in cis or in trans to recruit kinases to the surface. By improving the accessibility of immobilized peptide substrates to kinases in solution, the apparent rate of phosphorylation increased and assays were more sensitive to changes in endogenous kinase activities. These strategies can be generalized to improve the reactivity of most peptide substrates used in heterogeneous kinase assays with cell lysates. PMID:20593469

  6. General aviation activity and avionics survey. Annual summary report, CY 1985

    SciTech Connect

    Not Available

    1987-03-01

    This report presents the results and a description of the 1985 General Aviation Activity and Avionics Survey. The survey was conducted during 1986 by the FAA to obtain information on the activity and avionics of the United States registered general aviation aircraft fleet, the dominant component of civil aviation in the U.S. The survey was based on a statistically selected sample of about 10.3 percent of the general aviation fleet. A responses rate of 63.7 percent was obtained. Survey results based upon response but are expanded upward to represent the total population. Survey results revealed that during 1985 an estimated 34.1 million hours of flying time were logged and 88.7 million operations were performed by the 210,654 active general aviation aircraft in the U.S. fleet. The mean annual flight time per aircraft was 158.2 hours. The active aircraft represented about 77.9 percent of the registered general aviation fleet. The report contains breakdowns of these and other statistics by manufacturer/model group, aircraft, state and region of based aircraft, and primary use. Also included are fuel consumption, lifetime airframe hours, avionics, engine hours, and miles flown estimates, as well as tables for detailed analysis of the avionics capabilities of the general aviation fleet. New to the report this year are estimates of the number of landings, IFR hours flown, and the cost and grade of fuel consumed by the GA fleet.

  7. STS-99 Crew Activities Report / Flight Day 10 Highlights

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The primary objective of the STS-99 mission was to complete high resolution mapping of large sections of the Earth's surface using the Shuttle Radar Topography Mission (SRTM), a specially modified radar system. This radar system produced unrivaled 3-D images of the Earth's Surface. The mission was launched at 12:31 on February 11, 2000 onboard the space shuttle Endeavour. and led by Commander Kevin Kregel. The crew was Pilot Dominic L. Pudwill Gorie and Mission Specialists Janet L. Kavandi, Janice E. Voss, Mamoru Mohri from the National Space Development Agency (Japanese Space Agency), and Gerhard P. J. Thiele from DARA (German Space Agency). This tape shows the activities of the tenth day of the mission. During this day the mapping of the Earth continued. Each of the astronauts gives a brief statement about the mission or some other point of interest. Some of the equipment and supplies on board the shuttle are shown, including the medical supplies. The videotape ends showing some of the images released during the day from the SRTM. These include views of Oahu, Hawaii; Miquelon Island and St. Pierre Island, Newfoundland; Kamchatka, and Baikal, Russia; Oberpfaffenhofen, Germany; Katmandu, Nepal; and Cotopaxi, Ecuador.

  8. Stanford Synchrotron Radiation Laboratory. Activity report for 1988

    SciTech Connect

    Cantwell, K.

    1996-01-01

    For SSRL operations, 1988 was a year of stark contrasts. The first extended PEP parasitic running since the construction of our two beam lines on that storage ring took place in November and December. Four experiments discussed below, were performed and detailed operational procedures which allowed synchrotron radiation an high energy users to coexist were established. SSRL anticipates that there will be significant amounts of beam time when PEP is run again for high energy physics. On the other hand, activity on SPEAR consisted of brief parasitic running on the VUV lines in December when the ring was operated at 1.85 GeV for colliding beam experiments. There was no dedicated SPEAR running throughout the entire calendar year. This is the first time since dedicated SPEAR operation was initiated in 1980 that there was no such running. The decision was motivated by both cost and performance factors, as discussed in Section 1 of this report. Fortunately, SLAC and SSRL have reached an agreement on SPEAR and PEP dedicated time charges which eliminates the cost volatility which was so important in the cancellation of the June-July dedicated SPEAR run. As discussed in Section 2, the 3 GeV SPEAR injector construction is proceeding on budget and on schedule. The injector will overcome the difficulties associated with the SLC-era constraint of only two injections per day. SSR and SLAC have also embarked on a program to upgrade SPEAR to achieve high reliability and performance. As a consequence, SSRL`s users may anticipate a highly effective SPEAR by 1991, at the latest. At that time, SPEAR is expected to be fully dedicated to synchrotron radiation research and operated by SSRL. Also contained in this report is a discussion of the improvements to SSRL`s experimental facilities and highlights of the experiments of the past year.

  9. Benthic food web structure in the Comau fjord, Chile (∼42°S): Preliminary assessment including a site with chemosynthetic activity

    NASA Astrophysics Data System (ADS)

    Zapata-Hernández, Germán; Sellanes, Javier; Mayr, Christoph; Muñoz, Práxedes

    2014-12-01

    Using C and N stable isotopes we analyzed different trophic aspects of the benthic fauna at two sites in the Comau fjord: one with presence of venting of chemically reducing fluids and extensive patches of bacterial mats (XH: X-Huinay), and one control site (PG: Punta Gruesa) with a typical fjord benthic habitat. Due to the widespread presence of such microbial patches in the fjord and their recognized trophic role in reducing environments, we hypothesize that these microbial communities could be contributing to the assimilated food of consumers and transferring carbon into high trophic levels in the food web. Food sources in the area included macroalgae with a wide range of δ13C values (-34.7 to -11.9‰), particulate organic matter (POM, δ13C = -20.1‰), terrestrial organic matter (TOM, δ13C = -32.3‰ to -27.9‰) and chemosynthetic filamentous bacteria (δ13C = ∼-33‰). At both sites, fauna depicted typical values indicating photosynthetic production as a main food source (>-20‰). However, at XH selected taxa reported lower δ13C values (e.g. -26.5‰ in Nacella deaurata), suggesting a partial use of chemosynthetic production. Furthermore, enhanced variability at this site in δ13C values of the polyplacophoran Chiton magnificus, the limpet Fissurella picta and the tanaid Zeuxoides sp. may also be responding to the use of a wider scope of primary food sources. Trophic position estimates suggest three trophic levels of consumers at both sites. However, low δ15N values in some grazer and suspension-feeder species suggest that these taxa could be using other sources still to be identified (e.g. bacterial films, microalgae and organic particles of small size-fractions). Furthermore, between-site comparisons of isotopic niche width measurements in some trophic guilds indicate that grazers from XH have more heterogenic trophic niches than at PG (measured as mean distance to centroid and standard deviation of nearest neighbor distance). This last could be

  10. Security assessment of power systems including energy storage and with the integration of wind energy. Volume I. Digital transient simulation effort consulting Agreement No. 1. Final report

    SciTech Connect

    Anderson, P. M.

    1982-06-30

    The purpose of the effort reported has been to adapt the MOD-2 simulation models for implementation on a digital transient stability program. This has involved: selection of an appropriate host program, examination of the host program interface, analysis of the analog models for digital implementation, FORTRAN coding of the model equations, installation and debugging on the host program, and final model verification. Synchronous machine equations are analyzed, with particular emphasis on numerical solution. (LEW)

  11. Report of the Integrated Program Planning Activity for the DOE Fusion Energy Sciences Program

    SciTech Connect

    2000-12-01

    This report of the Integrated Program Planning Activity (IPPA) has been prepared in response to a recommendation by the Secretary of Energy Advisory Board that, ''Given the complex nature of the fusion effort, an integrated program planning process is an absolute necessity.'' We, therefore, undertook this activity in order to integrate the various elements of the program, to improve communication and performance accountability across the program, and to show the inter-connectedness and inter-dependency of the diverse parts of the national fusion energy sciences program. This report is based on the September 1999 Fusion Energy Sciences Advisory Committee's (FESAC) report ''Priorities and Balance within the Fusion Energy Sciences Program''. In its December 5,2000, letter to the Director of the Office of Science, the FESAC has reaffirmed the validity of the September 1999 report and stated that the IPPA presents a framework and process to guide the achievement of the 5-year goals listed in the 1999 report. The National Research Council's (NRC) Fusion Assessment Committee draft final report ''An Assessment of the Department of Energy's Office of Fusion Energy Sciences Program'', reviewing the quality of the science in the program, was made available after the IPPA report had been completed. The IPPA report is, nevertheless, consistent with the recommendations in the NRC report. In addition to program goals and the related 5-year, 10-year, and 15-year objectives, this report elaborates on the scientific issues associated with each of these objectives. The report also makes clear the relationships among the various program elements, and cites these relationships as the reason why integrated program planning is essential. In particular, while focusing on the science conducted by the program, the report addresses the important balances between the science and energy goals of the program, between the MFE and IFE approaches, and between the domestic and international aspects

  12. Effects of Lifestyle Interventions That Include a Physical Activity Component in Class II and III Obese Individuals: A Systematic Review and Meta-Analysis

    PubMed Central

    Baillot, Aurélie; Romain, Ahmed J.; Boisvert-Vigneault, Katherine; Audet, Mélisa; Baillargeon, Jean Patrice; Dionne, Isabelle J.; Valiquette, Louis; Chakra, Claire Nour Abou; Avignon, Antoine; Langlois, Marie-France

    2015-01-01

    Background In class II and III obese individuals, lifestyle intervention is the first step to achieve weight loss and treat obesity-related comorbidities before considering bariatric surgery. A systematic review, meta-analysis, and meta-regression were performed to assess the impact of lifestyle interventions incorporating a physical activity (PA) component on health outcomes of class II and III obese individuals. Methods An electronic search was conducted in 4 databases (Medline, Scopus, CINAHL and Sportdiscus). Two independent investigators selected original studies assessing the impact of lifestyle interventions with PA components on anthropometric parameters, cardiometabolic risk factors (fat mass, blood pressure, lipid and glucose metabolism), behaviour modification (PA and nutritional changes), and quality of life in adults with body mass index (BMI) ≥ 35 kg/m2. Estimates were pooled using a random-effect model (DerSimonian and Laird method). Heterogeneity between studies was assessed by the Cochran’s chi-square test and quantified through an estimation of the I². Results Of the 3,170 identified articles, 56 met our eligibility criteria, with a large majority of uncontrolled studies (80%). The meta-analysis based on uncontrolled studies showed significant heterogeneity among all included studies. The pooled mean difference in weight loss was 8.9 kg (95% CI, 10.2–7.7; p < 0.01) and 2.8 kg/m² in BMI loss (95% CI, 3.4–2.2; p < 0.01). Long-term interventions produced superior weight loss (11.3 kg) compared to short-term (7.2 kg) and intermediate-term (8.0 kg) interventions. A significant global effect of lifestyle intervention on fat mass, waist circumference, blood pressure, total cholesterol, LDL-C, triglycerides and fasting insulin was found (p<0.01), without significant effect on HDL-C and fasting blood glucose. Conclusions Lifestyle interventions incorporating a PA component can improve weight and various cardiometabolic risk factors in class II

  13. Should Non-Cognitive Skills Be Included in School Accountability Systems? Preliminary Evidence from California's CORE Districts. Evidence Speaks Reports, Vol 1, #13

    ERIC Educational Resources Information Center

    West, Martin R.

    2016-01-01

    Evidence confirms that student skills other than academic achievement and ability predict a broad range of academic and life outcomes. This evidence, along with a new federal requirement that state accountability systems include an indicator of school quality or student success not based on test scores, has sparked interest in incorporating such…

  14. PR[superscript 2]EPS: Preparation, Recruitment, Retention and Excellence in the Physical Sciences, Including Engineering. A Report on the 2004, 2005 and 2006 Science Summer Camps

    ERIC Educational Resources Information Center

    Bachman, Nancy J.; Bischoff, Paul J.; Gallagher, Hugh; Labroo, Sunil; Schaumloffel, John C.

    2008-01-01

    Now in its fourth year, PR[superscript 2]EPS is a National Science Foundation funded initiative designed to recruit high school students to attend college majoring in the physical sciences, including engineering and secondary science education, and to help ensure their retention within the program until graduation. A central feature of the…

  15. A multidisciplinary approach including the use of platelet-rich plasma to treat an elite athlete with patellar tendinopathy – a case report

    PubMed Central

    Rowan, Tracy L.; Drouin, Jillian L.

    2013-01-01

    Objective: Patellar tendinopathy affects a substantial proportion of athletes involved in jumping or kicking activities. Platelet rich plasma (PRP) injections may be a promising treatment used in conjunction with common traditional therapies. Clinical Features: Patellar tendinopathy is often the result of repetitive or excessive overload on the patellar tendon. Activity modification, cryotherapy, eccentric exercises, shockwave therapy, and PRP have been indicated as treatment options during various stages of this condition. Intervention and Outcome: A 23 year old female, elite track and field athlete was managed for patellar tendinopathy with a combination of traditional therapeutic interventions as well as a PRP injection. This athlete returned to pre-injury level of competition six months post-injection. Conclusion: Emerging literature on PRP appears to be promising for patellar tendinopathy, however, it remains unclear which patients may benefit most and whether the stage of the disorder has an impact on the clinical outcome. PMID:24302777

  16. Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

    PubMed Central

    Kono, Mari; Tucker, Ana E.; Tran, Jennifer; Bergner, Jennifer B.; Turner, Ewa M.; Proia, Richard L.

    2014-01-01

    Activation of the GPCR sphingosine-1-phosphate receptor 1 (S1P1) by sphingosine-1-phosphate (S1P) regulates key physiological processes. S1P1 activation also has been implicated in pathologic processes, including autoimmunity and inflammation; however, the in vivo sites of S1P1 activation under normal and disease conditions are unclear. Here, we describe the development of a mouse model that allows in vivo evaluation of S1P1 activation. These mice, known as S1P1 GFP signaling mice, produce a S1P1 fusion protein containing a transcription factor linked by a protease cleavage site at the C terminus as well as a β-arrestin/protease fusion protein. Activated S1P1 recruits the β-arrestin/protease, resulting in the release of the transcription factor, which stimulates the expression of a GFP reporter gene. Under normal conditions, S1P1 was activated in endothelial cells of lymphoid tissues and in cells in the marginal zone of the spleen, while administration of an S1P1 agonist promoted S1P1 activation in endothelial cells and hepatocytes. In S1P1 GFP signaling mice, LPS-mediated systemic inflammation activated S1P1 in endothelial cells and hepatocytes via hematopoietically derived S1P. These data demonstrate that S1P1 GFP signaling mice can be used to evaluate S1P1 activation and S1P1-active compounds in vivo. Furthermore, this strategy could be potentially applied to any GPCR to identify sites of receptor activation during normal physiology and disease. PMID:24667638

  17. Occurrence and morphological comparisons of Campula oblonga (Digenea: Campulidae), including a report from an atypical host, the thresher shark, Alopias vulpinus.

    PubMed

    Adams, A M; Hoberg, E P; McAlpine, D F; Clayden, S L

    1998-04-01

    New host records for Campula oblonga Cobbold, 1858 from the common dolphin, Delphinus delphis L., and from the thresher shark, Alopias vulpinus (Bonnaterre), are reported herein. Campulids have not been reported previously from a host that was not a marine mammal. The excellent condition and small size of the gravid specimen and the diet and natural history of the thresher shark lead us to conclude that the digene was acquired from the consumption of infected fish. Specimens of C. oblonga from these 2 hosts and from harbor porpoises, Phocoena phocoena (L.), and from Dall's porpoises, Phocoenoides dalli (True), are compared, and a wide variation in ranges and values for characters is noted. The synonymy of Campula folium Ozaki, 1935 with C. oblonga is further supported by the apparent effect of the host on the size of the trematodes. Due to the degree of variation in measurements and the numerous factors that may impact these values, we recommend the use of qualitative morphologic characters for the identification of C. oblonga.

  18. Final report on electric vehicle activities, September 1991--October 1994

    SciTech Connect

    Del Monaco, J.L.; Pandya, D.A.

    1995-02-01

    The data and information collected for the Public Service Electric and Gas Company`s (PSE&G) electric vehicle demonstration program were intended to support and enhance DOE`s Electric and Hybrid Vehicle Site Operator Program. The DOE Site Operator Program is focused on the life cycle and reliability of Electric Vehicles (EVs). Of particular interest are vehicles currently available with features that are likely to be put into production or demonstrate new technology. PSE&G acquired eight GMC Electric G-Vans in 1991, and three TEVans in 1993, and conducted a program plan to test and assess the overall performance of these electric vehicles. To accomplish the objectives of DOE`s Site Operator`s test program, a manual data collection system was implemented. The manual data collection system has provided energy use and mileage data. From September 1991 to October 1994 PSE&G logged 69,368 miles on eleven test vehicles. PSE&G also demonstrated the EVs to diverse groups and associations at fifty seven various events. Included in the report are lessons learned concerning maintenance, operation, public reactions, and driver`s acceptance of the electric vehicles.

  19. Antrim shale workshop. Held in Mt. Pleasant, Michigan on December 14, 1993. (Collection of speaker visuals including tables, charts, illustrations). Topical report

    SciTech Connect

    Not Available

    1993-12-01

    The collection of speaker visuals includes tables, charts, illustrations, schematics, and other graphical and textual summaries, of presentations at the 1993 Antrim Shale workshop, where the following topics were discussed: applied well testing; stimulating the shale; procedures to identify recompletion candidates; pipeline systems for the shale development; mineralogic, petrophysical, and organic geochemical properties of the shale; natural fracture identification and implications for production; application of coiled tubing downhole tools; control of normally occurring radioactive materials; and regional hydrogeochemistry.

  20. Orbital Fracture Leading to Severe Multifascial Space Infection Including the Parapharyngeal Space: A Report of a Case and Review of the Literature

    PubMed Central

    Park, Chan; Marchiori, Erica; Barber, Jacob; Cardon, Curtis

    2014-01-01

    Orbital trauma can result in periorbital and orbital infections. Orbital infections have been classified by Chandler et al in 1970 to their anatomic location and boundaries. This case report describes a patient who developed a severe orbital infection following orbital fractures. The infection progressed to the parapharyngeal space. The patient required multiple incision and drainage surgeries and tissue debridements to have clinical resolution. To our knowledge, there has not been a case described in the literature of an orbital infection progressing to the parapharyngeal space. A literature review of orbital trauma leading to infection discusses the pathogenesis of the infections. This case demonstrates that close clinical follow-up and appropriate medical management of comorbidities that put a patient at higher risk of developing an infection is of the utmost importance in the treatment of maxillofacial trauma patients. PMID:25136414