Science.gov

Sample records for activities resources required

  1. Nutrition Activities Resource Guide.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Special Education.

    The resource guide suggests activities to help special education students make appropriate choices about their nutritional habits. It is explained that the activities can be infused into other curriculum areas. The guide consists of five themes and includes performance objectives for each: foods eaten at school (planning a school lunch, keeping a…

  2. Lunar resource recovery: A definition of requirements

    NASA Technical Reports Server (NTRS)

    Elsworth, D.; Kohler, J. L.; Alexander, S. S.

    1992-01-01

    The capability to locate, mine, and process the natural resources of the Moon will be an essential requirement for lunar base development and operation. The list of materials that will be necessary is extensive and ranges from oxygen and hydrogen for fuel and life support to process tailings for emplacement over habitats. Despite the resources need, little is known about methodologies that might be suitable for utilizing lunar resources. This paper examines some of the requirements and constraints for resource recovery and identifies key areas of research needed to locate, mine, and process extraterrestrial natural resources.

  3. Resource requirements for evaluating ambulatory health care.

    PubMed Central

    Thompson, M S; Palmer, R H; Rothrock, J K; Strain, R; Brachman, L H; Wright, E A

    1984-01-01

    We implemented the most frequently used form of quality assurance activity: abstracting information on the quality of patient care from medical records and communicating findings to providers in 16 ambulatory care groups. Site providers accepted the evaluation criteria, agreed that deficiencies in care were detected, and, for some medical tasks, effected improvements in care. Direct costs in 1980 dollars for the quality assurance cycle including data system development were $46 per evaluated case. Per-case costs varied considerably among tasks, decreased with larger numbers of cases and as experience grew, and were reduced through computerization. Measured costs were high due to: a demanding research design; our extended accounting of direct, indirect, and induced costs; and the substantial resource requirements of rigorously performed evaluations. PMID:6496817

  4. Hamiltonian gadgets with reduced resource requirements

    NASA Astrophysics Data System (ADS)

    Cao, Yudong; Babbush, Ryan; Biamonte, Jacob; Kais, Sabre

    2015-01-01

    Application of the adiabatic model of quantum computation requires efficient encoding of the solution to computational problems into the lowest eigenstate of a Hamiltonian that supports universal adiabatic quantum computation. Experimental systems are typically limited to restricted forms of two-body interactions. Therefore, universal adiabatic quantum computation requires a method for approximating quantum many-body Hamiltonians up to arbitrary spectral error using at most two-body interactions. Hamiltonian gadgets, introduced around a decade ago, offer the only current means to address this requirement. Although the applications of Hamiltonian gadgets have steadily grown since their introduction, little progress has been made in overcoming the limitations of the gadgets themselves. In this experimentally motivated theoretical study, we introduce several gadgets which require significantly more realistic control parameters than similar gadgets in the literature. We employ analytical techniques which result in a reduction of the resource scaling as a function of spectral error for the commonly used subdivision, three- to two-body and k -body gadgets. Accordingly, our improvements reduce the resource requirements of all proofs and experimental proposals making use of these common gadgets. Next, we numerically optimize these gadgets to illustrate the tightness of our analytical bounds. Finally, we introduce a gadget that simulates a Y Y interaction term using Hamiltonians containing only {X ,Z ,X X ,Z Z } terms. Apart from possible implications in a theoretical context, this work could also be useful for a first experimental implementation of these key building blocks by requiring less control precision without introducing extra ancillary qubits.

  5. FIREX mission requirements document for renewable resources

    NASA Technical Reports Server (NTRS)

    Carsey, F.; Dixon, T.

    1982-01-01

    The initial experimental program and mission requirements for a satellite synthetic aperture radar (SAR) system FIREX (Free-Flying Imaging Radar Experiment) for renewable resources is described. The spacecraft SAR is a C-band and L-band VV polarized system operating at two angles of incidence which is designated as a research instrument for crop identification, crop canopy condition assessments, soil moisture condition estimation, forestry type and condition assessments, snow water equivalent and snow wetness assessments, wetland and coastal land type identification and mapping, flood extent mapping, and assessment of drainage characteristics of watersheds for water resources applications. Specific mission design issues such as the preferred incidence angles for vegetation canopy measurements and the utility of a dual frequency (L and C-band) or dual polarization system as compared to the baseline system are addressed.

  6. Resources required for topological quantum factoring

    SciTech Connect

    Baraban, M.; Bonesteel, N. E.; Simon, S. H.

    2010-06-15

    We consider a hypothetical topological quantum computer composed of either Ising or Fibonacci anyons. For each case, we calculate the time and number of qubits (space) necessary to execute the most computationally expensive step of Shor's algorithm, modular exponentiation. For Ising anyons, we apply Bravyi's distillation method [S. Bravyi, Phys. Rev. A 73, 042313 (2006)] which combines topological and nontopological operations to allow for universal quantum computation. With reasonable restrictions on the physical parameters we find that factoring a 128-bit number requires approximately 10{sup 3} Fibonacci anyons versus at least 3x10{sup 9} Ising anyons. Other distillation algorithms could reduce the resources for Ising anyons substantially.

  7. FIREX mission requirements document for nonrenewable resources

    NASA Technical Reports Server (NTRS)

    Dixon, T.; Carsey, F.

    1982-01-01

    The proposed mission requirements and a proposed experimental program for satellite synthetic aperture radar (SAR) system named FIREX (Free-Flying Imaging Radar Experiment) for nonrenewable resources is described. The recommended spacecraft minimum SAR system is a C-band imager operating in four modes: (1) low look angle HH-polarized; (2) intermediate look angle, HH-polarized; (3) intermediate look angle, IIV-polarized; and (4) high look angle HH-polarized. This SAR system is complementary to other future spaceborne imagers such as the Thematic Mapper on LANDSAT-D. A near term aircraft SAR based research program is outlined which addresses specific mission design issues such as preferred incidence angles or polarizations for geologic targets of interest.

  8. 14 CFR 1274.904 - Resource sharing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Resource sharing requirements. 1274.904... AGREEMENTS WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.904 Resource sharing requirements. Resource Sharing Requirements July 2002 Where NASA and other Government agencies are involved...

  9. 14 CFR 1274.904 - Resource sharing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Resource sharing requirements. 1274.904... AGREEMENTS WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.904 Resource sharing requirements. Resource Sharing Requirements July 2002 Where NASA and other Government agencies are involved...

  10. 14 CFR 1274.904 - Resource sharing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Resource sharing requirements. 1274.904... AGREEMENTS WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.904 Resource sharing requirements. Resource Sharing Requirements July 2002 Where NASA and other Government agencies are involved...

  11. 14 CFR 1274.904 - Resource sharing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Resource sharing requirements. 1274.904... AGREEMENTS WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.904 Resource sharing requirements. Resource Sharing Requirements July 2002 Where NASA and other Government agencies are involved...

  12. 14 CFR § 1274.904 - Resource sharing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Resource sharing requirements. § 1274.904... AGREEMENTS WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.904 Resource sharing requirements. Resource Sharing Requirements July 2002 Where NASA and other Government agencies are involved...

  13. Spacelab user implementation assessment study. Volume 3: Resource requirements development

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The resources requirements for the integration and checkout of spacelab payloads are presented in three categories: mission-unique, sustaining, and non-recurring. The requirements are identified by concept and by center. Cost estimates for the resource requirements are also presented.

  14. 15 CFR 970.519 - Resource conservation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Resource conservation requirements. 970.519 Section 970.519 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each license issued under...

  15. 15 CFR 971.420 - Resource conservation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Resource conservation requirements. 971.420 Section 971.420 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each permit issued under...

  16. 15 CFR 971.420 - Resource conservation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Resource conservation requirements. 971.420 Section 971.420 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each permit issued under...

  17. 15 CFR 970.519 - Resource conservation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Resource conservation requirements. 970.519 Section 970.519 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each license issued under...

  18. 15 CFR 971.420 - Resource conservation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Resource conservation requirements. 971.420 Section 971.420 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each permit issued under...

  19. 15 CFR 970.519 - Resource conservation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Resource conservation requirements. 970.519 Section 970.519 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each license issued under...

  20. 15 CFR 971.420 - Resource conservation requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Resource conservation requirements. 971.420 Section 971.420 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each permit issued under...

  1. 15 CFR 970.519 - Resource conservation requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Resource conservation requirements. 970.519 Section 970.519 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each license issued under...

  2. 15 CFR 971.420 - Resource conservation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Resource conservation requirements. 971.420 Section 971.420 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each permit issued under...

  3. 15 CFR 970.519 - Resource conservation requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Resource conservation requirements. 970.519 Section 970.519 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... conservation requirements. For the purpose of conservation of natural resources, each license issued under...

  4. 75 FR 63113 - Financial Resources Requirements for Derivatives Clearing Organizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... COMMISSION 17 CFR Parts 39 and 140 RIN 3038-AC98, 3038-AD02 Financial Resources Requirements for Derivatives... statutory provisions enacted by Title VII and Title VIII of the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd-Frank Act). The proposed regulations establish financial resources requirements...

  5. Spacelab mission dependent training parametric resource requirements study

    NASA Technical Reports Server (NTRS)

    Ogden, D. H.; Watters, H.; Steadman, J.; Conrad, L.

    1976-01-01

    Training flows were developed for typical missions, resource relationships analyzed, and scheduling optimization algorithms defined. Parametric analyses were performed to study the effect of potential changes in mission model, mission complexity and training time required on the resource quantities required to support training of payload or mission specialists. Typical results of these analyses are presented both in graphic and tabular form.

  6. Assessment of Geothermal Data Resources and Requirements

    SciTech Connect

    none,

    2008-09-01

    This paper is a review of Geothermal Technologies Program activities and archives related to data collection and analysis. It includes an assessment of the current state of geothermal data, future program and stakeholder data needs, existence of and access to critical data, and high-level direction and prioritization of next steps to meet the Program’s data needs.

  7. Youth Physical Activity Resource Use and Activity Measured by Accelerometry

    ERIC Educational Resources Information Center

    Maslow, Andra L.; Colabianchi, Natalie

    2011-01-01

    Objectives: To examine whether use of physical activity resources (e.g., parks) was associated with daily physical activity measured by accelerometry. Methods: One hundred eleven adolescents completed a travel diary with concurrent accelerometry. The main exposure was self-reported use of a physical activity resource (none /1 resources). The main…

  8. Functional Requirements for Information Resource Provenance on the Web

    SciTech Connect

    McCusker, James P.; Lebo, Timothy; Graves, Alvaro; Difranzo, Dominic; Pinheiro da Silva, Paulo; McGuinness, Deborah L.

    2012-06-19

    We provide a means to formally explain the relationship between HTTP URLs and the representations returned when they are requested. According to existing World Wide Web architecture, the URL serves as an identier for a semiotic referent while the document returned via HTTP serves as a representation of the same referent. This begins with two sides of a semiotic triangle; the third side is the relationship between the URL and the representation received. We complete this description by extending the library science resource model Functional Requirements for Bibliographic Resources (FRBR) with cryptographic message and content digests to create a Functional Requirements for Information Resources (FRIR). We show how applying the FRIR model to HTTP GET and POST transactions disambiguates the many relationships between a given URL and all representations received from its request, provides fine-grained explanations that are complementary to existing explanations of web resources, and integrates easily into the emerging W3C provenance standard.

  9. Earth resources mission performance studies. Volume 1: Requirements definition

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The need for a realistic set of earth resources collection requirements to test and maximize the data gathering capabilities of the EOS remote sensor systems is considered. The collection requirements will be derived from established user requirements. In order to confine and bound the requirements study, some baseline assumptions were established. These are: (1) image acquisition is confined to the contiguous United States, (2) the fundamental data users are select participating federal agencies, (3) the acquired data will be applied to generating information necessary or in support of existing federal agency charters, and (4) the most pressing or desired federal agency earth resources data requirements have been defined, suggested, or implied in current available literature.

  10. Education Requirements for Natural Resource Based Outdoor Recreation Professionals.

    ERIC Educational Resources Information Center

    Elsner, Gary; And Others

    The Office of Personnel Management should designate a new professional series for hiring individuals in outdoor recreational management. A new professional series would help set a standard for professionals with training in both resource management and the social sciences. Recommended educational requirements for the series include: (1) natural…

  11. The Resource Requirements Prediction Model 1 (RRPM-1): An Overview.

    ERIC Educational Resources Information Center

    Gulko, Warren W.

    This paper provides a brief overview of the conceptual approach used in the initial version of the WICHE Resource Requirements Prediction Model (RRPM-1). RRPM-1 is an institutional-oriented, computer-based model which simulates the cost of operating a college campus over a 3- to 10-year time frame. The model may be viewed as a management tool to…

  12. Design requirements for operational earth resources ground data processing

    NASA Technical Reports Server (NTRS)

    Baldwin, C. J.; Bradford, L. H.; Burnett, E. S.; Hutson, D. E.; Kinsler, B. A.; Kugle, D. R.; Webber, D. S.

    1972-01-01

    Realistic tradeoff data and evaluation techniques were studied that permit conceptual design of operational earth resources ground processing systems. Methodology for determining user requirements that utilize the limited information available from users is presented along with definitions of sensor capabilities projected into the shuttle/station era. A tentative method is presented for synthesizing candidate ground processing concepts.

  13. Water resources activities of the USGS, 1992

    USGS Publications Warehouse

    Smith, E. T.

    1993-01-01

    The Water Resources Division (WRD) of the U.S. Geological Survey has the principal responsibility within the Federal Government for providing hydrologic information and appraising the Nation's water resources. The USGS is unique among government organizations because it has neither regulatory nor developmental authority. Information that is made available equally to all interested parties is the sole product of the WRD. The mission, organization, source of funds, and major programs of the WRD are discussed in this report. Three types of programs are described: long-term programs, topical programs, and support programs. Emphasis is on programs that will contribute to identifying, mitigating, or solving nationwide water-resources problems in the remaining years of the 20th century. Completing the report are discussions of how the hydrologic data and information are disseminated and an index. The report describes the water-resources mission of the WRD and discusses the organization and principal sources of funds that support the activities conducted to meet this mission. Descriptions are given of the most significant water-resources activities, how the hydrologic data and information are disseminated is discussed. Each description of a significant water-resources activity has the following parts: 'Introduction', 'Activities', 'Recent Accomplishments' and 'Funding'. (USGS)

  14. Activation of nonlocal quantum resources.

    PubMed

    Navascués, Miguel; Vértesi, Tamás

    2011-02-11

    We find two two-qubit bipartite states ρ1, ρ2 such that arbitrarily many copies of one or the other cannot exhibit nonlocal correlations in a two-setting-two-outcome Bell scenario. However, the bipartite state ρ1 ⊗ ρ2 violates the Clauser-Horne-Shimony-Holt (CHSH) Bell inequality [J. F. Clauser, M. A. Horne, A. Shimony, and R. A. Holt, Phys. Rev. Lett. 23, 880 (1969).] by an amount of 2.023. We also identify a CHSH-local state ρ such that ρ⊗2 is CHSH inequality-violating. The tools employed can be easily adapted to find instances of nonlocality activation in arbitrary Bell scenarios.

  15. 18 CFR 390.2 - Activities requiring registration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... registration. 390.2 Section 390.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURAL RULES ELECTRONIC REGISTRATION § 390.2 Activities requiring registration. (a) Electronic registration is a requirement for the following activities: (1) Submission of...

  16. RoboResource Technology Learning Activities.

    ERIC Educational Resources Information Center

    Keck, Tom, Comp.; Frye, Ellen, Ed.

    Preparing students to be successful in a rapidly changing world means showing them how to use the tools of technology and how to integrate those tools into all areas of learning. This booklet is divided into three sections: Design Activities, Experiments, and Resources. The design activities ask students to collaborate on design projects. In these…

  17. Energy resource requirements of a solar heating system

    NASA Astrophysics Data System (ADS)

    Rogers, D. W. O.

    1980-01-01

    The paper addresses the question of the total energy resource use of a solar hot water and space heating system compared to the traditional oil, gas and electric heating options. The methods of energy analysis have been applied to a liquid-based, short-term storage solar space and water heating system for a dwelling in Toronto, and the results indicate that the indirect use of energy resources does not have a major impact on the overall energy conservation characteristics of the system which, being in many respects a worst case, takes 1.0-3.5 years of operation to conserve the energy resources, required to build, operate and maintain the system. Over the assumed 20-year lifetime the solar heating system, sized to provide 50% of the heating requirement to a house, uses between 53 and 62% as many energy resources as a conventional system, heating the same house. The energy-conservation characteristics of the system can be completely negated by the use of thermally generated electricity as backup in a 50% solar heating system which replaces oil or gas heating. The collectors and annual operating energy for the pumps were found to be the two most significant factors in the analysis.

  18. Resource requirements for digital computations on electrooptical systems

    NASA Astrophysics Data System (ADS)

    Eshaghian, Mary M.; Panda, Dhabaleswar K.; Kumar, V. K. Prasanna

    1991-03-01

    The resource requirements of electrooptical organizations in performing digital computing tasks are studied via a generic model of parallel computation using optical interconnects, called the 'optical model of computation' (OMC). In this model, computation is performed in digital electronics and communication is performed using free space optics. Relationships between information transfer and computational resources in solving a given problem are derived. A computationally intensive operation, two-dimensional digital image convolution is undertaken. Irrespective of the input/output scheme and the order of computation, a lower bound of Omega(nw) is obtained on the optical volume required for convolving a w x w kernel with an n x n image, if the input bits are given to the system only once.

  19. Resource Requirements Planning for Hospitals Treating Serious Infectious Disease Cases

    SciTech Connect

    Vugrin, Eric D.; Verzi, Stephen Joseph; Finley, Patrick D.; Turnquist, Mark A.; Wyte-Lake, Tamar; Griffin, Ann R.; Ricci, Karen J.; Plotinsky, Rachel

    2015-02-01

    This report presents a mathematical model of the way in which a hospital uses a variety of resources, utilities and consumables to provide care to a set of in-patients, and how that hospital might adapt to provide treatment to a few patients with a serious infectious disease, like the Ebola virus. The intended purpose of the model is to support requirements planning studies, so that hospitals may be better prepared for situations that are likely to strain their available resources. The current model is a prototype designed to present the basic structural elements of a requirements planning analysis. Some simple illustrati ve experiments establish the mo del's general capabilities. With additional inve stment in model enhancement a nd calibration, this prototype could be developed into a useful planning tool for ho spital administrators and health care policy makers.

  20. Defining Requirements for an Integrated Water Resource Modeling System

    SciTech Connect

    Thurman, David A.; Peterson, Todd S.; Frodge, Jonathan

    2002-07-29

    This paper describes the process used to define the requirements for an integrated water resource modeling system that will be employed by a range of users with varying backgrounds and needs. A five-step process was initiated to ensure consideration of the needs and interests of users representing many different parts of the organization. The steps of the process, the results of each step and a summary of the results are presented.

  1. Resource Requirements of the Pacific Leatherback Turtle Population

    PubMed Central

    Jones, T. Todd; Bostrom, Brian L.; Hastings, Mervin D.; Van Houtan, Kyle S.; Pauly, Daniel; Jones, David R.

    2012-01-01

    The Pacific population of leatherback sea turtles (Dermochelys coriacea) has drastically declined in the last 25 years. This decline has been linked to incidental capture by fisheries, egg and meat harvesting, and recently, to climate variability and resource limitation. Here we couple growth rates with feeding experiments and food intake functions to estimate daily energy requirements of leatherbacks throughout their development. We then estimate mortality rates from available data, enabling us to raise food intake (energy requirements) of the individual to the population level. We place energy requirements in context of available resources (i.e., gelatinous zooplankton abundance). Estimated consumption rates suggest that a single leatherback will eat upward of 1000 metric tonnes (t) of jellyfish in its lifetime (range 924–1112) with the Pacific population consuming 2.1×106 t of jellyfish annually (range 1.0–3.7×106) equivalent to 4.2×108 megajoules (MJ) (range 2.0–7.4×108). Model estimates suggest 2–7 yr-old juveniles comprise the majority of the Pacific leatherback population biomass and account for most of the jellyfish consumption (1.1×106 t of jellyfish or 2.2×108 MJ per year). Leatherbacks are large gelatinous zooplanktivores with consumption to biomass ratios of 96 (up to 192 if feeding strictly on low energy density Cnidarians); they, therefore, have a large capacity to impact gelatinous zooplankton landscapes. Understanding the leatherback's needs for gelatinous zooplankton, versus the availability of these resources, can help us better assess population trends and the influence of climate induced resource limitations to reproductive output. PMID:23071518

  2. Resource requirements of the Pacific leatherback turtle population.

    PubMed

    Jones, T Todd; Bostrom, Brian L; Hastings, Mervin D; Van Houtan, Kyle S; Pauly, Daniel; Jones, David R

    2012-01-01

    The Pacific population of leatherback sea turtles (Dermochelys coriacea) has drastically declined in the last 25 years. This decline has been linked to incidental capture by fisheries, egg and meat harvesting, and recently, to climate variability and resource limitation. Here we couple growth rates with feeding experiments and food intake functions to estimate daily energy requirements of leatherbacks throughout their development. We then estimate mortality rates from available data, enabling us to raise food intake (energy requirements) of the individual to the population level. We place energy requirements in context of available resources (i.e., gelatinous zooplankton abundance). Estimated consumption rates suggest that a single leatherback will eat upward of 1000 metric tonnes (t) of jellyfish in its lifetime (range 924-1112) with the Pacific population consuming 2.1×10(6) t of jellyfish annually (range 1.0-3.7×10(6)) equivalent to 4.2×10(8) megajoules (MJ) (range 2.0-7.4×10(8)). Model estimates suggest 2-7 yr-old juveniles comprise the majority of the Pacific leatherback population biomass and account for most of the jellyfish consumption (1.1×10(6) t of jellyfish or 2.2×10(8) MJ per year). Leatherbacks are large gelatinous zooplanktivores with consumption to biomass ratios of 96 (up to 192 if feeding strictly on low energy density Cnidarians); they, therefore, have a large capacity to impact gelatinous zooplankton landscapes. Understanding the leatherback's needs for gelatinous zooplankton, versus the availability of these resources, can help us better assess population trends and the influence of climate induced resource limitations to reproductive output.

  3. Early Childhood: Activity Books and Resource Guides.

    ERIC Educational Resources Information Center

    National Center on Educational Media and Materials for the Handicapped, Columbus, OH.

    Selected from the National Instructional Materials Information System (NIMIS)--a computer based on-line interactive retrieval system on special education materials--the bibliography covers 59 activity books and resource guides for developing skills at the early childhood level. Entries are presented in order of NIMIS accession number and include…

  4. Front Range Infrastructure Resources Project: water-resources activities

    USGS Publications Warehouse

    Robson, Stanley G.; Heiny, Janet S.

    1998-01-01

    Infrastructure, such as roads, buildings, airports, and dams, is built and maintained by use of large quantities of natural resources such as aggregate (sand and gravel), energy, and water. As urban area expand, local sources of these resource are becoming inaccessible (gravel cannot be mined from under a subdivision, for example), or the cost of recovery of the resource becomes prohibitive (oil and gas drilling in urban areas is costly), or the resources may become unfit for some use (pollution of ground water may preclude its use as a water supply). Governmental land-use decision and environmental mandates can further preclude development of natural resources. If infrastructure resources are to remain economically available. current resource information must be available for use in well-reasoned decisions bout future land use. Ground water is an infrastructure resource that is present in shallow aquifers and deeper bedrock aquifers that underlie much of the 2,450-square-mile demonstration area of the Colorado Front Range Infrastructure Resources Project. In 1996, mapping of the area's ground-water resources was undertaken as a U.S. Geological Survey project in cooperation with the Colorado Department of Natural Resources, Division of Water Resources, and the Colorado Water Conservation Board.

  5. Army Corps of Engineers: Water Resource Authorizations, Appropriations, and Activities

    DTIC Science & Technology

    2016-02-09

    Army Corps of Engineers: Water Resource Authorizations, Appropriations, and Activities Nicole T. Carter Specialist in Natural Resources Policy...of Engineers: Water Resource Authorizations, Appropriations, and Activities Congressional Research Service Summary The U.S. Army Corps of...typically called the Water Resources Development Act (WRDA) or more recently the Water Resources Reform and Development Act of 2014 (WRRDA 2014

  6. Water-resources activities in Florida, 1988-89

    USGS Publications Warehouse

    Glenn, Mildred E.

    1989-01-01

    This report contains summary statements of water resources activities in Florida conducted by the Water Resources Division of the U.S. Geological Survey in cooperation with Federal, State , and local agencies during 1988. These activities are part of the Federal program of appraising the Nation 's water resources. Included are brief descriptions of the nature and scope of all active studies, summaries of significant results for 1988 and anticipated accomplishments during 1989. Water resources appraisals in Florida are highly diversified, ranging from hydrologic records networks to interpretive appraisals of water resources and applied research to develop investigative techniques. Thus, water-resources investigations range from basic descriptive water-availability studies for areas of low-intensity water development and management to sophisticated cause and effect studies in areas of high-intensity water development and management. The interpretive reports and records that are products of the investigations are a principal hydrologic foundation upon which the plans for development, management, and protection of Florida 's water resources may be used. Water data and information required to implement sound water-management programs in highly urbanized areas relate to the quantity and quality of storm runoff, sources of aquifer contamination, injection of wastes into deep strata, underground storage of freshwater, artificial recharge of aquifers, environmental effects of reuse of water, and effects of land development on changes in ground-and surface-water quality. In some parts of the State broad areas are largely rural. Future growth is anticipated in many of these. This report is intended to inform those agencies vitally interested in the water resources of Florida as to the current status and objectives of the U.S. Geological Survey cooperative program. The mission of this program is to collect, interpret, and publish information on water resources. Almost all of

  7. Water resources activities in Kentucky, 1986

    USGS Publications Warehouse

    Faust, R. J.

    1986-01-01

    The U.S. Geological Survey, Water Resources Division, conducts three major types of activities in Kentucky in order to provide hydrologic information and understanding needed for the best management of Kentucky 's and the Nation 's water resources. These activities are: (1) Data collection and dissemination; (2) Water-resources appraisals (interpretive studies); and (3) Research. Activities described in some detail following: (1) collection of surface - and groundwater data; (2) operation of stations to collect data on water quality, atmospheric deposition, and sedimentation; (3) flood investigations; (4) water use; (5) small area flood hydrology; (6) feasibility of disposal of radioactive disposal in deep crystalline rocks; (7) development of a groundwater model for the Louisville area; (8) travel times for streams in the Kentucky River Basin; (9) the impact of sinkholes and streams on groundwater flow in a carbonate aquifer system; (10) sedimentation and erosion rates at the Maxey Flats Radioactive Waste Burial site; and (11) evaluation of techniques for evaluating the cumulative impacts of mining as applied to coal fields in Kentucky. (Lantz-PTT)

  8. Front Range Infrastructure Resources Project--Aggregate Resources Activities

    USGS Publications Warehouse

    ,

    1998-01-01

    Infrastructure, such as roads, buildings, airports, and dams, is built and maintained by use of large quantities of aggregate—sand, gravel, and stone. As urban areas expand, local sources of these resources become inaccessible. Other competitive land uses have a higher value than aggregate resources. For example, gravel cannot be mined from under a subdivision. The failure to plan for the protection and extraction of infrastructure resources often results in increased consumer cost, environmental damage, and an adversarial relationship between the industry and the community.

  9. Front Range Infrastructure Resources Project; energy resources activities

    USGS Publications Warehouse

    ,

    1998-01-01

    Oil, natural gas, and coal (energy resources) have been produced from rocks in the Front Range of Colorado and Wyoming for more than a century, and significant quantities of oil and gas continue to be developed in the study area of the U.S. Geological Survey (USGS) Front Range Infrastructure Resources Project (fig. 1). As an infrastructure resource, energy resources helped to fuel past development of (1) urban areas in the Front Range as well as (2) some of the manufacturing and mining upon which the urban centers were built and thrived. At present, much of the oil and gas extracted from rocks beneath the Front Range urban corridor is used locally; the people living in the urban area provide a need and viable marketplace for these commodities.

  10. 43 CFR 1784.6-1 - Resource advisory councils-requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Resource advisory councils-requirements... Advisory Committees § 1784.6-1 Resource advisory councils—requirements. (a) Resource advisory councils... participation. (b) A resource advisory council advises the Bureau of Land Management official to whom it...

  11. 43 CFR 1784.6-1 - Resource advisory councils-requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Resource advisory councils-requirements... Advisory Committees § 1784.6-1 Resource advisory councils—requirements. (a) Resource advisory councils... participation. (b) A resource advisory council advises the Bureau of Land Management official to whom it...

  12. 43 CFR 1784.6-1 - Resource advisory councils-requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Resource advisory councils-requirements... Advisory Committees § 1784.6-1 Resource advisory councils—requirements. (a) Resource advisory councils... participation. (b) A resource advisory council advises the Bureau of Land Management official to whom it...

  13. 43 CFR 1784.6-1 - Resource advisory councils-requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Resource advisory councils-requirements... Advisory Committees § 1784.6-1 Resource advisory councils—requirements. (a) Resource advisory councils... participation. (b) A resource advisory council advises the Bureau of Land Management official to whom it...

  14. Science requirements for free-flying imaging radar (FIREX) experiment for sea ice, renewable resources, nonrenewable resources and oceanography

    NASA Technical Reports Server (NTRS)

    Carsey, F.

    1982-01-01

    A future bilateral SAR program was studied. The requirements supporting a SAR mission posed by science and operations in sea-ice-covered waters, oceanography, renewable resources, and nonrenewable resources are addressed. The instrument, mission, and program parameters were discussed. Research investigations supporting a SAR flight and the subsequent overall mission requirements and tradeoffs are summarized.

  15. A case study of exploiting enterprise resource planning requirements

    NASA Astrophysics Data System (ADS)

    Niu, Nan; Jin, Mingzhou; Cheng, Jing-Ru C.

    2011-05-01

    The requirements engineering (RE) processes have become a key to conceptualising corporate-wide integrated solutions based on packaged enterprise resource planning (ERP) software. The RE literature has mainly focused on procuring the most suitable ERP package. Little is known about how an organisation exploits the chosen ERP RE model to frame the business application development. This article reports an exploratory case study of a key tenet of ERP RE adoption, namely that aligning business applications to the packaged RE model leads to integral practices and economic development. The case study analysed a series interrelated pilot projects developed for a business division of a large IT manufacturing and service company, using Oracle's appl1ication implementation method (AIM). The study indicated that AIM RE improved team collaboration and project management experience, but needed to make hidden assumptions explicit to support data visibility and integrity. Our study can direct researchers towards rigorous empirical evaluations of ERP RE adoption, collect experiences and lessons learned for practitioners, and help generate more effective and mature processes when exploiting ERP RE methods.

  16. Water resource requirements of corn-based ethanol

    NASA Astrophysics Data System (ADS)

    Mubako, Stanley; Lant, Christopher

    2008-07-01

    Ethanol derived from fermentation of corn is a very water-intensive product with water to ethanol mass ratios of 927 to 1178 and volumetric ratios of 1174 to 1492 for the major rainfed corn-growing U.S. states of Illinois and Iowa and the leading irrigated corn-growing state of Nebraska, respectively. Over 99% of water requirements are for growing corn feed stocks, with 99% of that amount in Illinois and Iowa, occurring as evapotranspiration of rainfall in corn fields, and 60% as evapotranspiration of applied irrigation water in Nebraska. As a rough measure of water quality impacts, 65.5 g N, 23.8 g P, and 1.03 g of pesticides are applied, and 4.8 kg of soil is eroded per liter of ethanol produced. These results add to knowledge on corn-based ethanol's low net energy balance and high carbon footprint by demonstrating the high water resource intensity of corn-based ethanol production.

  17. 48 CFR 873.109 - General requirements for acquisition of health-care resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...-care resources, consisting of commercial services or the use of medical equipment or space, utilizing... acquisition of health-care resources. 873.109 Section 873.109 Federal Acquisition Regulations System... HEALTH-CARE RESOURCES 873.109 General requirements for acquisition of health-care resources. (a)...

  18. 14 CFR § 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information technology resources. § 1274.937 Section § 1274.937 Aeronautics and Space NATIONAL AERONAUTICS... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be...

  19. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be...

  20. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be...

  1. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be...

  2. Survey of resource opportunities and critical evaluation of economic requirements

    NASA Technical Reports Server (NTRS)

    Clark, Benton C.

    1991-01-01

    A series of mission analyses were performed to evaluate human mission to Mars and the moon with and without the aid of planetary resource utilization. The types of trade studies that are considered include the use of resources to manufacture propellant, food, habitat atmospheric gases, and lander habitat structure. Also, the potential for export of resources from the moon, Mars, Phobos, Deimos, and selected asteroids is also examined. In all cases, mass leveraging is evaluated. For certain cases, economic factors are evaluated as well. It is concluded that some uses are highly leveraging on the mission, whereas others have lesser impact and, therefore, should be afforded lesser priority in resource utilization studies. This survey is made with a consistent set of scaling laws for spacecraft propulsion and habitation systems and subsystems, and therefore, provides a rational basis for comparing different resource locations and use strategies.

  3. Indianapolis resource recovery facility; Community efforts and technology required for a successful project

    SciTech Connect

    Stevens, P.L. ); Henderson, J.S. ); Tulli, R. )

    1990-01-01

    There are many community needs. Refuse is an abundant byproduct of our civilization. The disposal of this byproduct has become a major problem for our cities. This paper describes on community's efforts to turn a community problem, refuse disposal, into a community asset. The paper describes the many aspects of effort and technology required to develop the Indianapolis Resource Recovery Facility. This facility required the cooperation of the public and private sectors to blend technology into a successful project. Special efforts were required to match appropriate technology to specific community needs and produce a successful and economically sound project. Five basic activities are presented. The first four activities are essential steps for any community to assure the right project fit to community needs. The areas presented are: defining community needs, technology evaluation (approaches evaluated), feasibility studies (economic studies), project implementation (bids and contracts), and a description of the Indianapolis resource recovery facility. A review of these five areas places a real world perspective on refuse as an alternative fuel and source of resource recovery.

  4. PUBLIC PERCEPTIONS OF NATURAL RESOURCE DAMAGES AND THE RESOURCES THAT REQUIRE RESTORATION

    PubMed Central

    Burger, Joanna

    2014-01-01

    The public and health professionals are interested in restoring degraded ecosystem to provide goods and services. This study examined public perceptions in coastal New York and New Jersey about who is responsible for restoration of resources, which resources should be restored, by whom, and do they know the meaning of natural resource damage assessment (NRDA). More than 98% felt that resources should be restored; more (40%) thought the government should restore them, rather than the responsible party (23%). The highest rated resources were endangered wildlife, fish, mammals, and clams/crabs. Only 2% of respondents knew what NRDA meant. These data indicate that people felt strongly that resources should be restored and varied in who should restore them, suggesting that governmental agencies must clarify the relationship between chemical discharges, resource injury, NRDA, and restoration of those resources to produce clean air and water, fish and wildlife, and recreational opportunities. PMID:20711934

  5. Public perceptions of natural resource damages and the resources that require restoration.

    PubMed

    Burger, Joanna

    2010-01-01

    The public and health professionals are interested in restoring degraded ecosystem to provide goods and services. This study examined public perceptions in coastal New York and New Jersey about who is responsible for restoration of resources, which resources should be restored, by whom, and do they know the meaning of natural resource damage assessment (NRDA). More than 98% felt that resources should be restored; more (40%) thought the government should restore them, rather than the responsible party (23%). The highest rated resources were endangered wildlife, fish, mammals, and clams/crabs. Only 2% of respondents knew what NRDA meant. These data indicate that people felt strongly that resources should be restored and varied in who should restore them, suggesting that governmental agencies must clarify the relationship between chemical discharges, resource injury, NRDA, and restoration of those resources to produce clean air and water, fish and wildlife, and recreational opportunities.

  6. Resource requirements for a quality Doctor of Nursing Practice program.

    PubMed

    Frantz, Rita A

    2013-08-01

    Fundamental to planning, implementing, and sustaining a quality Doctor of Nursing Practice (DNP) program is access to the resources needed to foster a learning environment that prepares nurses for advanced practice and leadership in the future redesigned health care system. This creates formidable challenges for schools and colleges of nursing as they endeavor to address the nation's need for an increased supply of advanced practice nurses to provide access to high-quality, cost-effective care for an aging population. This article describes the essential resources needed to support the delivery of a DNP program and the proposed strategies needed to address the resource challenges.

  7. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... (IT) resources....

  8. Precise Geodetic Infrastructure: National Requirements for a Shared Resource

    NASA Astrophysics Data System (ADS)

    Minster, J. H.; Altamimi, Z.; Blewitt, G.; Carter, W. E.; Cazenave, A. A.; Dragert, H.; Herring, T.; Larson, K. M.; Ries, J. C.; Sandwell, D. T.; Wahr, J. M.; Davis, J. L.; Feary, D. A.; Shanley, L. A.; Nrc Committee On The National RequirementsPrecision Geodetic Infrastructure

    2010-12-01

    Recognizing the growing reliance of a wide range of scientific and societal endeavors on infrastructure for precise geodesy, and recognizing geodetic infrastructure as a shared national resource, NASA, USNO, NGA (DoD), NSF, NGS (NOAA), and USGS requested the National Research Council (NRC) to provide an independent assessment of the benefits provided by geodetic observations and networks, as well as a plan for the future development and support of the infrastructure needed to meet the demand for increasingly greater precision. We recommend in this study that “The United States, to maintain leadership in industry and science, and as a matter of national security, should invest in maintaining and improving the geodetic infrastructure, through upgrades in network design and construction, modernization of current observing systems, deployment of improved multi-technique observing capabilities, and funding opportunities for research, analysis, and education in global geodesy.” Today’s precise global geodetic infrastructure is fragile, and we also recommend (1) an international cooperative effort to increase the density of the international geodetic network with a goal of reaching a network of at least 24 fundamental stations; (2) a national GNSS network constructed to scientific specifications, capable of streaming high-rate data in real-time, with no restrictions on data access; (3) continued support of international geodetic services; (4) a long-term commitment to maintain the International Terrestrial Reference Frame. The astonishing advances toward higher geodetic accuracy at increasing temporal resolution are made possible only by all components of the geodetic infrastructure working together as a coherent system. The components of the geodetic infrastructure, however, are dispersed among various departments, agencies, and organizations. The nation’s precise geodetic infrastructure has not been considered holistically before now. Nevertheless, it is a

  9. Ecosystem Matters: Activity and Resource Guide for Environmental Educators.

    ERIC Educational Resources Information Center

    Adams, Mary; And Others

    An ecological approach involved making conscious decisions which result in actions that responsibly contribute to the long-term stewardship of natural resources. This activity and resource guide was designed for use by both educators and resource managers to supplement existing courses and programs concerning ecological matters. These…

  10. Resource Requirements and Costs of Developing and Delivering MOOCs

    ERIC Educational Resources Information Center

    Hollands, Fiona M.; Tirthali, Devayani

    2014-01-01

    Given the ongoing alarm regarding uncontrollable costs of higher education, it would be reasonable to expect not only concern about the impact of MOOCs on educational outcomes, but also systematic efforts to document the resources expended on their development and delivery. However, there is little publicly available information on MOOC costs that…

  11. Excellent end of life care requires time and resources.

    PubMed

    2017-02-22

    Delivering excellent end of life care is among the biggest challenges faced by nurses today, regardless of their level of experience or place of work. Just about every nurse will be confronted with a dying patient at some stage, so it is essential they have the training and resources to cope.

  12. Earth resources requirements Skylab missions SL-1/SL-2, SL-3, and SL-4. Appendix B: Mission requirements

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Earth resources requirements to be investigated by Skylab missions 1 through 4 are presented tabularly. Areas to be investigated include: (1) agriculture, range, and forestry; (2) geology; (3) continental water resources; (4) ocean investigations; (5) atmospheric investigations; (6) coastal zones, shoals, and bays; (7) remote sensing techniques; and (8) cartography.

  13. 25 CFR 161.200 - Is an Indian agricultural resource management plan required?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Is an Indian agricultural resource management plan... resource management plan required? (a) Yes, Navajo Partitioned Lands must be managed in accordance with the goals and objectives in the agricultural resource management plan developed by the Navajo Nation, or...

  14. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information...

  15. 48 CFR 352.239-72 - Security requirements for Federal information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Federal information technology resources. 352.239-72 Section 352.239-72 Federal Acquisition Regulations... Provisions and Clauses 352.239-72 Security requirements for Federal information technology resources. As... Federal Information Technology Resources (January 2010) (a) Applicability. This clause applies whether...

  16. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information...

  17. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information...

  18. 48 CFR 352.239-72 - Security requirements for Federal information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Federal information technology resources. 352.239-72 Section 352.239-72 Federal Acquisition Regulations... Provisions and Clauses 352.239-72 Security requirements for Federal information technology resources. As... Federal Information Technology Resources (January 2010) (a) Applicability. This clause applies whether...

  19. 48 CFR 352.239-72 - Security requirements for Federal information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Federal information technology resources. 352.239-72 Section 352.239-72 Federal Acquisition Regulations... Provisions and Clauses 352.239-72 Security requirements for Federal information technology resources. As... Federal Information Technology Resources (January 2010) (a) Applicability. This clause applies whether...

  20. 48 CFR 352.239-72 - Security requirements for Federal information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Federal information technology resources. 352.239-72 Section 352.239-72 Federal Acquisition Regulations... Provisions and Clauses 352.239-72 Security requirements for Federal information technology resources. As... Federal Information Technology Resources (January 2010) (a) Applicability. This clause applies whether...

  1. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information...

  2. 48 CFR 652.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Unclassified Information Technology Resources. 652.239-71 Section 652.239-71 Federal Acquisition Regulations... Provisions and Clauses 652.239-71 Security Requirements for Unclassified Information Technology Resources. As... Technology Resources (SEP 2007) (a) General. The Contractor shall be responsible for information...

  3. Force Reduction Impacts on Resourcing Army Operational Requirements

    DTIC Science & Technology

    2017-03-10

    resource operational forces examines how externally imposed reductions in Army end strength and related force structure changes drive demand and...Further clarification of planned force structure changes by HQDA, announced after the completion of vignettes 1 and 2, were also incorporated. It...10 Figure 5. New Supply (MOS 19K30E6K4 – Tank Crew) Vignette 4 applies the same force structure changes made for Vignette 3 but applies the

  4. 48 CFR 1352.239-72 - Security requirements for information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... information technology resources. 1352.239-72 Section 1352.239-72 Federal Acquisition Regulations System... Clauses 1352.239-72 Security requirements for information technology resources. As prescribed in 48 CFR 1339.270(b), insert the following clause: Security Requirements for Information Technology...

  5. 48 CFR 1352.239-72 - Security requirements for information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... information technology resources. 1352.239-72 Section 1352.239-72 Federal Acquisition Regulations System... Clauses 1352.239-72 Security requirements for information technology resources. As prescribed in 48 CFR 1339.270(b), insert the following clause: Security Requirements for Information Technology...

  6. 48 CFR 1352.239-72 - Security requirements for information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... information technology resources. 1352.239-72 Section 1352.239-72 Federal Acquisition Regulations System... Clauses 1352.239-72 Security requirements for information technology resources. As prescribed in 48 CFR 1339.270(b), insert the following clause: Security Requirements for Information Technology...

  7. 48 CFR 1352.239-72 - Security requirements for information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... information technology resources. 1352.239-72 Section 1352.239-72 Federal Acquisition Regulations System... Clauses 1352.239-72 Security requirements for information technology resources. As prescribed in 48 CFR 1339.270(b), insert the following clause: Security Requirements for Information Technology...

  8. USGS Mineral Resources Program: International Activities

    USGS Publications Warehouse

    Kropschot, S.J.

    1998-01-01

    The USGS is the country's leading earth science organization. Since 1879, USGS scientists have gathered and analyzed data and disseminated the results of their research on the geology, cartography, hydrology, and, more recently biology, of every continent and ocean on Earth. Multidisciplinary research both in the United States and in the international arena has been an important part of the USGS mission. The USGS Mineral Resources Program is the sole Federal agency program that provides high-quality scientific information, objective resource assessments, and unbiased research results on mineral issues

  9. Universe At Your Fingertips: An Astronomy Activity and Resource Notebook.

    ERIC Educational Resources Information Center

    Fraknoi, Andrew, Ed.

    The goal of this resource notebook is to provide activities selected by astronomers and classroom teachers, comprehensive resource lists and bibliographies, background material on astronomical topics, and teaching ideas from experienced astronomy educators. The activities are grouped into several major areas of study in astronomy: lunar phases and…

  10. Water resources activities, Georgia District, 1986

    USGS Publications Warehouse

    Casteel, Carolyn A.; Ballew, Mary D.

    1987-01-01

    The U.S. Geological Survey, through its Water Resources Division , investigates the occurrence, quantity, quality, distribution, and movement of the surface and underground water that composes the Nation 's water resources. Much of the work is a cooperative effort in which planning and financial support are shared by state and local governments and other federal agencies. This report contains a brief description of the water-resources investigations in Georgia in which the Geological Survey participates, and a list of selected references. Water-resources data for the 1985 water year for Georgia consists of records of stage, discharge, and water quality of streams; stage and contents of lakes and reservoirs; and groundwater levels. These data include discharge records for 108 gaging stations; water quality for 43 continuous stations, 109 periodic stations, and miscellaneous sites; peak stage and discharge only for 130 crest-stage partial-record stations and 44 miscellaneous sites; and water levels of 27 observation wells. Nineteen Georgia District projects are summarized. (Lantz-PTT)

  11. Estrogenic flavonoids: structural requirements for biological activity.

    PubMed

    Miksicek, R J

    1995-01-01

    A systematic survey of polycyclic phenols has been performed to identify members of this chemical group with estrogenic activity. Twelve compounds were found to be able to stimulate the transcriptional activity of the human estrogen receptor expressed in cultured cells by transient transfection. These natural estrogens belong to several distinct, but chemically related classes including chalcones, flavanones, flavones, flavonols, and isoflavones. Selected examples of estrogenic flavonoids were further analyzed to determine their biological potencies and their relative affinities for binding to the estrogen receptor. These data are interpreted with respect to the molecular structure of polycyclic phenols required for hormonal activity as nonsteroidal estrogens.

  12. Resources and Biological Activities of Natural Polyphenols

    PubMed Central

    Li, An-Na; Li, Sha; Zhang, Yu-Jie; Xu, Xiang-Rong; Chen, Yu-Ming; Li, Hua-Bin

    2014-01-01

    The oxidative stress imposed by reactive oxygen species (ROS) plays an important role in many chronic and degenerative diseases. As an important category of phytochemicals, phenolic compounds universally exist in plants, and have been considered to have high antioxidant ability and free radical scavenging capacity, with the mechanism of inhibiting the enzymes responsible for ROS production and reducing highly oxidized ROS. Therefore, phenolic compounds have attracted increasing attention as potential agents for preventing and treating many oxidative stress-related diseases, such as cardiovascular diseases, cancer, ageing, diabetes mellitus and neurodegenerative diseases. This review summarizes current knowledge of natural polyphenols, including resource, bioactivities, bioavailability and potential toxicity. PMID:25533011

  13. Resources and biological activities of natural polyphenols.

    PubMed

    Li, An-Na; Li, Sha; Zhang, Yu-Jie; Xu, Xiang-Rong; Chen, Yu-Ming; Li, Hua-Bin

    2014-12-22

    The oxidative stress imposed by reactive oxygen species (ROS) plays an important role in many chronic and degenerative diseases. As an important category of phytochemicals, phenolic compounds universally exist in plants, and have been considered to have high antioxidant ability and free radical scavenging capacity, with the mechanism of inhibiting the enzymes responsible for ROS production and reducing highly oxidized ROS. Therefore, phenolic compounds have attracted increasing attention as potential agents for preventing and treating many oxidative stress-related diseases, such as cardiovascular diseases, cancer, ageing, diabetes mellitus and neurodegenerative diseases. This review summarizes current knowledge of natural polyphenols, including resource, bioactivities, bioavailability and potential toxicity.

  14. Power requirements for mining and microwave processing of extraterrestrial resources

    NASA Technical Reports Server (NTRS)

    Leonard, Raymond S.; Johnson, Stewart W.

    1988-01-01

    Research in progress on the use of nuclear power in mining the Martian moons for volatiles and hydrocarbons as well as to power microwave generators for processing both lunar regolith and the spoils from the Martian mines into building materials is described. Previous work on mining the Martian moons developed estimates for the costs and power requirements for extracting and shipping any volatiles that might be found on Phobos and Diemos. The costs were compared to the cost of shipping the same volatiles from Earth and it was found that the mining operation would break even for launch costs from Earth as low as ninety dollars per pound (198 dollars/kg). Above this figure the mines would generate a profit. Based on the results of recent work on the microwave processing of lunar regolith it was decided to refine the concept description. Work under way and to be reported deals with a better definition of the power required for mine operations, nuclear propulsion, and microwave materials processing.

  15. Sustainable resource use requires "clean cycles" and safe "final sinks".

    PubMed

    Kral, Ulrich; Kellner, Katharina; Brunner, Paul H

    2013-09-01

    In order to fulfill the objectives of environmental protection, today's focus on quantitative recycling rates must be amended by a more qualitative approach. Because modern products represent a mix of numerous and sometimes hazardous substances, ways must be explored to remove detrimental substances during recycling and to establish "clean cycles". On the one hand, such a "clean cycle" strategy will result in better recycling qualities of secondary products and less dissipation of hazardous substances during further product use. On the other hand, the elimination of hazardous substances during recycling requires sinks for the disposal of the eliminated materials. These topics are presented in general as well as by case studies. In particular, the sink issue is addressed, differentiating between sinks and final sinks and discussing the challenge to supply appropriate final sinks for all materials that cannot be recycled.

  16. Mineral supply for sustainable development requires resource governance

    NASA Astrophysics Data System (ADS)

    Ali, Saleem H.; Giurco, Damien; Arndt, Nicholas; Nickless, Edmund; Brown, Graham; Demetriades, Alecos; Durrheim, Ray; Enriquez, Maria Amélia; Kinnaird, Judith; Littleboy, Anna; Meinert, Lawrence D.; Oberhänsli, Roland; Salem, Janet; Schodde, Richard; Schneider, Gabi; Vidal, Olivier; Yakovleva, Natalia

    2017-03-01

    Successful delivery of the United Nations sustainable development goals and implementation of the Paris Agreement requires technologies that utilize a wide range of minerals in vast quantities. Metal recycling and technological change will contribute to sustaining supply, but mining must continue and grow for the foreseeable future to ensure that such minerals remain available to industry. New links are needed between existing institutional frameworks to oversee responsible sourcing of minerals, trajectories for mineral exploration, environmental practices, and consumer awareness of the effects of consumption. Here we present, through analysis of a comprehensive set of data and demand forecasts, an interdisciplinary perspective on how best to ensure ecologically viable continuity of global mineral supply over the coming decades.

  17. An approach to estimating human resource requirements to achieve the Millennium Development Goals.

    PubMed

    Dreesch, Norbert; Dolea, Carmen; Dal Poz, Mario R; Goubarev, Alexandre; Adams, Orvill; Aregawi, Maru; Bergstrom, Karin; Fogstad, Helga; Sheratt, Della; Linkins, Jennifer; Scherpbier, Robert; Youssef-Fox, Mayada

    2005-09-01

    In the context of the Millennium Development Goals, human resources represent the most critical constraint in achieving the targets. Therefore, it is important for health planners and decision-makers to identify what are the human resources required to meet those targets. Planning the human resources for health is a complex process. It needs to consider both the technical aspects related to estimating the number, skills and distribution of health personnel for meeting population health needs, and the political implications, values and choices that health policy- and decision-makers need to make within given resources limitations. After presenting an overview of the various methods for planning human resources for health, with their advantages and limitations, this paper proposes a methodological approach to estimating the requirements of human resources to achieve the goals set forth by the Millennium Declaration. The method builds on the service-target approach and functional job analysis.

  18. Groundwater: A Vital Resource. Student Activities.

    ERIC Educational Resources Information Center

    Taylor, Carla, Ed.

    Twenty-three activities dealing with various aspects of groundwater are provided in this manual. The activities are arranged under four headings: (1) the water cycle; (2) water distribution in soils (considering such topics as calculating water table depth and purifying water by filtering); (3) water quality (considering such topics as acid rain,…

  19. USGS international activities in coal resources

    USGS Publications Warehouse

    ,

    1999-01-01

    During the last 30 years the U.S. Geological Survey (USGS) has been engaged in coal exploration and characterization in more that 30 foreign countries, including India, Pakistan, China, Turkey, several Eastern European countries, Russia, and other former Soviet Union countries. Through this work, the USGS has developed an internationally recognized capability for assessing coal resources and defining their geochemical and physical characteristics. More recently, these data have been incorporated into digital databases and Geographic Information System (GIS) digital map products. The USGS has developed a high level of expertise in assessing the technological, economic, environmental, and human health impacts of coal occurrences and utilization based on comprehensive characterization of representative coal samples.

  20. 48 CFR 1352.239-72 - Security requirements for information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Security requirements for... Clauses 1352.239-72 Security requirements for information technology resources. As prescribed in 48 CFR 1339.270(b), insert the following clause: Security Requirements for Information Technology...

  1. 25 CFR 166.311 - Is an Indian agricultural resource management plan required?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Is an Indian agricultural resource management plan... WATER GRAZING PERMITS Land and Operations Management Management Plans and Environmental Compliance § 166.311 Is an Indian agricultural resource management plan required? (a) Indian agricultural land...

  2. Scaling Up Child and Adolescent Mental Health Services in South Africa: Human Resource Requirements and Costs

    ERIC Educational Resources Information Center

    Lund, Crick; Boyce, Gerard; Flisher, Alan J.; Kafaar, Zuhayr; Dawes, Andrew

    2009-01-01

    Background: Children and adolescents with mental health problems have poor service cover in low- and middle-income countries. Little is known about the resources that would be required to provide child and adolescent mental health services (CAMHS) in these countries. The purpose of this study was to calculate the human resources and associated…

  3. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JAN 2012) (a) General. The Contractor shall be responsible for...

  4. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible...

  5. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information...

  6. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JAN 2012) (a) General. The Contractor shall be responsible for...

  7. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible...

  8. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information...

  9. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JAN 2012) (a) General. The Contractor shall be responsible for...

  10. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information...

  11. Satellite Power System (SPS) resource requirements (critical materials, energy and land)

    NASA Technical Reports Server (NTRS)

    Kotin, A. D.

    1978-01-01

    The resource impacts of the proposed satellite power system are evaluated. Three classes of resource impacts are considered separately: critical materials, energy, and land use. The analysis focuses on the requirements associated with the annual development of two five-gigawatt satellites and the associated receiving facilities.

  12. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information...

  13. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible...

  14. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information...

  15. 48 CFR 552.239-71 - Security Requirements for Unclassified Information Technology Resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Unclassified Information Technology Resources. 552.239-71 Section 552.239-71 Federal Acquisition Regulations... Text of Provisions and Clauses 552.239-71 Security Requirements for Unclassified Information Technology... Information Technology Resources (JUN 2011) (a) General. The Contractor shall be responsible for...

  16. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible...

  17. A Pilot Test of the Resource Requirements Prediction Model at Humboldt State College.

    ERIC Educational Resources Information Center

    California State Colleges, Inglewood. Office of the Chancellor.

    This publication presents Humboldt State College's experience with the pilot testing of the Resource Requirements Prediction Model (RRPM), an analytic computer designed to aid management decisionmaking and planning in institutions of higher education. RRPM has great potential as a planning tool that can improve resource management in higher…

  18. 25 CFR 166.311 - Is an Indian agricultural resource management plan required?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... WATER GRAZING PERMITS Land and Operations Management Management Plans and Environmental Compliance § 166.311 Is an Indian agricultural resource management plan required? (a) Indian agricultural land under... 25 Indians 1 2010-04-01 2010-04-01 false Is an Indian agricultural resource management...

  19. Update of wind resource assessment activities at NREL

    SciTech Connect

    Elliott, D L; Schwartz, M N

    1996-07-01

    The goal of the wind resource assessment activity at the National Renewable Energy Laboratory (NREL) is to improve the characterization of the wind resource for regions where there are market opportunities for U.S. wind energy technology. A variety of wind resource assessment activities have recently been undertaken at NREL in support of this effort. The major tasks during the past year include aiding the establishment of new wind measurement programs in the United States, the development of updated comprehensive meteorological and geographical data bases to be used for resource assessments in the United States and abroad, and designing progressive wind resource mapping tools to facilitate products used in support of emerging markets.

  20. Preface: Terrestrial Fieldwork to Support in situ Resource Utilization (ISRU) and Robotic Resource Prospecting for Future Activities in Space

    NASA Astrophysics Data System (ADS)

    Sanders, Gerald B.

    2015-05-01

    Finding, extracting, and using resources at the site of robotic and human exploration activities holds the promise of enabling sustainable and affordable exploration of the Moon, Mars, and asteroids, and eventually allow humans to expand their economy and habitation beyond the surface of the Earth. Commonly referred to as in situ Resource Utilization (ISRU), mineral and volatile resources found in space can be converted into oxygen, water, metals, fuels, and manufacturing and construction materials (such as plastics and concrete) for transportation, power, life support, habitation construction, and part/logistics manufacturing applications. For every kilogram of payload landed on the surface of the Moon or Mars, 7.5-11 kg of payload (mostly propellant) needs to be launched into low Earth orbit. Therefore, besides promising long-term self-sufficiency and infrastructure growth, ISRU can provide significant reductions in launch costs and the number of launches required. Key to being able to use space resources is knowing where they are located, how much is there, and how the resources are distributed. While ISRU holds great promise, it has also never been demonstrated in an actual space mission. Therefore, operations and hardware associated with each ISRU prospecting, excavation, transportation, and processing step must be examined, tested, and finally integrated to enable the end goal of using space resources in future human space missions.

  1. 30 CFR 280.30 - What activities will not require environmental analysis?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What activities will not require environmental analysis? 280.30 Section 280.30 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...) Shipboard hard mineral assaying and analysis; and (j) Placement of positioning systems, including...

  2. 30 CFR 280.30 - What activities will not require environmental analysis?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What activities will not require environmental analysis? 280.30 Section 280.30 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE PROSPECTING FOR MINERALS OTHER THAN OIL, GAS, AND SULPHUR...

  3. 30 CFR 280.25 - When may MMS require me to stop activities under this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false When may MMS require me to stop activities under this part? 280.25 Section 280.25 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE PROSPECTING FOR MINERALS OTHER THAN OIL, GAS,...

  4. Dealing efficiently with emotions: acceptance-based coping with negative emotions requires fewer resources than suppression.

    PubMed

    Alberts, Hugo J E M; Schneider, Francine; Martijn, Carolien

    2012-01-01

    Previous studies have consistently shown that changing or avoiding emotions requires resources and therefore leads to impaired performance on a subsequent self-control task. The aim of the present study was to investigate the extent to which acceptance-based coping requires regulatory resources. Participants who accepted their emotions during exposure to a sad video performed better on a subsequent self-control task than participants who were instructed to suppress their emotions and a control group who received no instructions. These findings suggest that acceptance is an efficient strategy in terms of resources.

  5. Advanced extravehicular activity systems requirements definition study

    NASA Technical Reports Server (NTRS)

    1988-01-01

    A study to define the requirements for advanced extravehicular activities (AEVA) was conducted. The purpose of the study was to develop an understanding of the EVA technology requirements and to map a pathway from existing or developing technologies to an AEVA system capable of supporting long-duration missions on the lunar surface. The parameters of an AEVA system which must sustain the crewmembers and permit productive work for long periods in the lunar environment were examined. A design reference mission (DRM) was formulated and used as a tool to develop and analyze the EVA systems technology aspects. Many operational and infrastructure design issues which have a significant influence on the EVA system are identified.

  6. Some Astronomy 101 Activities Using Internet Resources

    NASA Astrophysics Data System (ADS)

    West, M. L.

    2000-12-01

    Reputable Internet sites provide a wealth of visual, textual, and numerical data for student activities, as well as some fun simulations. Three activities will be described which have been used in Astronomy 101 classes for non-science students. An exercise in model making and problem solving uses the Astronomy Workshop (janus.astro.umd.edu/astro/impact.html) of the University of Maryland. This site provides a quick simulation of an impact with a planet. One can choose the target, the projectile composition (icy, rocky, or iron), the projectile's diameter, and the projectile's speed. The output provides the energy of impact, the earthquake magnitude, the crater's diameter and depth, and the frequency of such impacts. Students run simulations, pool their data, then collaborate to try to figure out the numerical model behind the simulations. They make predictions, test them, and learn that graphing and physical insight are both important tools. Extrasolar planets are now numerous and fascinating. Students use data from Geoff Marcy's group (www.exoplanets.org) to calculate the masses of the planets using a spreadsheet. They discover that the masses of the stars must depend on spectral type. Correlations among parameters are investigated graphically. As a preparation for writing term papers students review and critique selected sites (csam.montclair.edu/ west/ideasresources.html, west/astrolnk.html), discuss them in small groups, then present the "best" sites to the whole class. Teamwork, evaluation, critical thinking, and public speaking skills are emphasized in this class session. The students find these collaborative activities to be exciting, challenging, and enjoyable as well as increasing their science literacy and problem solving skills.

  7. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information...

  8. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information...

  9. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information...

  10. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information...

  11. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Security requirements for unclassified... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security... for Information Technology security for all systems connected to a NASA network or operated by...

  12. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Security requirements for access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Within Industry 3004.470 Security requirements for access to unclassified facilities,...

  13. 10 CFR 719.15 - What are the requirements for a staffing and resource plan?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false What are the requirements for a staffing and resource plan? 719.15 Section 719.15 Energy DEPARTMENT OF ENERGY CONTRACTOR LEGAL MANAGEMENT REQUIREMENTS Legal... such phases; (3) Projected cost for each phase of the representation; and (4) Numbers and mix...

  14. WATER: Water Activities Teaching Environmental Responsibility: Teacher Resource, Environmental Science.

    ERIC Educational Resources Information Center

    Kramer, Ed, Ed.; And Others

    This activity book was developed as part of an effort to protect water quality of the Stillwater River, Ohio, through a Watershed Protection Project. It is designed to raise teachers' and students' awareness and trigger a sense of stewardship towards the preservation of water resources. The activities are generally appropriate for elementary age…

  15. Earth resources-regional transfer activity contracts review

    NASA Technical Reports Server (NTRS)

    Bensko, J., Jr.; Daniels, J. L.; Downs, S. W., Jr.; Jones, N. L.; Morton, R. R.; Paludan, C. T.

    1977-01-01

    A regional transfer activity contracts review held by the Earth Resources Office was summarized. Contracts in the earth resources field primarily directed toward applications of satellite data and technology in solution of state and regional problems were reviewed. A summary of the progress of each contract was given in order to share experiences of researchers across a seven state region. The region included Missouri, Kentucky, Tennessee, Mississippi, Alabama, Georgia, and North Carolina. Research in several earth science disciplines included forestry, limnology, water resources, land use, geology, and mathematical modeling. The use of computers for establishment of information retrieval systems was also emphasized.

  16. Natural resource management activities at the Savannah River Site. Environmental Assessment

    SciTech Connect

    Not Available

    1993-07-01

    This environmental assessment (EA) reviews the environmental consequences of ongoing natural resource management activities on the Savannah River Site (SRS). Appendix A contains the Natural Resources Management Plant (NRMP). While several SRS organizations have primary responsibilities for different elements of the plan, the United States Department of Agriculture (USDA), Forest Service, Savannah River Forest Station (SRFS) is responsible for most elements. Of the river scenarios defined in 1985, the High-Intensity Management alternative established the upper bound of environmental consequences; it represents a more intense level of resource management than that being performed under current resource management activities. This alternative established compliance mechanisms for several natural resource-related requirements and maximum practical timber harvesting. Similarly, the Low-Intensity Management alternative established the lower bound of environmental consequences and represents a less intense level of resource management than that being performed under current resource management activities. This alternative also established compliance mechanisms, but defined a passively managed natural area. The Proposed Action of this EA describes the current level of multiple-natural resource management. This EA reviews the proposed action, and the high and low intensity alternative scenarios.

  17. Integrating natural resource damage assessment and environmental restoration activities at DOE facilities

    SciTech Connect

    1993-10-01

    Environmental restoration activities are currently under way at many U.S. Department of Energy (DOE) sites under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. DOE is the CERCLA lead response agency for these activities. Section 120 of CERCLA also could subject DOE to liability for natural resource damages resulting from hazardous substance releases at its sites. A Natural Resource Damage Assessment (NRDA) process is used to determine whether natural resources have been injured and to calculate compensatory monetary damages to be used to restore the natural resources. In addition to restoration costs, damages may include costs of conducting the damage assessment and compensation for interim losses of natural resource services that occur before resource restoration is complete. Natural resource damages represent a potentially significant source of additional monetary claims under CERCLA, but are not well known or understood by many DOE staff and contractors involved in environmental restoration activities. This report describes the requirements and procedures of NRDA in order to make DOE managers aware of what the process is designed to do. It also explains how to integrate the NRDA and CERCLA Remedial Investigation/Feasibility Study processes, showing how the technical and cost analysis concepts of NRDA can be borrowed at strategic points in the CERCLA process to improve decisionmaking and more quickly restore natural resource services at the lowest total cost to the public.

  18. Integrating Natural Resource Damage Assessment and environmental restoration activities at DOE facilities

    SciTech Connect

    Not Available

    1993-10-01

    Environmental restoration activities are currently under way at many US Department of Energy (DOE) sites under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). DOE is the CERCLA lead response agency for these activities. Section 120 of CERCLA also could subject DOE to liability for natural resource damages resulting from hazardous substance releases at its sites. A Natural Resource Damage Assessment (NRDA) process is used to determine whether natural resources have been injured and to calculate compensatory monetary damages to be used to restore the natural resources. In addition to restoration costs, damages may include costs of conducting the damage assessment and compensation for interim losses of natural resource services that occur before resource restoration is complete. Natural resource damages represent a potentially significant source of additional monetary claims under CERCLA, but are not well known or understood by many DOE staff and contractors involved in environmental restoration activities. This report describes the requirements and procedures of NRDA in order to make DOE managers aware of what the process is designed to do. It also explains how to integrate the NRDA and CERCLA Remedial Investigation/Feasibility Study processes, showing how the technical and cost analysis concepts of NRDA can be borrowed at strategic points in the CERCLA process to improve decisionmaking and more quickly restore natural resource services at the lowest total cost to the public.

  19. Constraints on global fire activity vary across a resource gradient.

    PubMed

    Krawchuk, Meg A; Moritz, Max A

    2011-01-01

    We provide an empirical, global test of the varying constraints hypothesis, which predicts systematic heterogeneity in the relative importance of biomass resources to burn and atmospheric conditions suitable to burning (weather/climate) across a spatial gradient of long-term resource availability. Analyses were based on relationships between monthly global wildfire activity, soil moisture, and mid-tropospheric circulation data from 2001 to 2007, synthesized across a gradient of long-term averages in resources (net primary productivity), annual temperature, and terrestrial biome. We demonstrate support for the varying constraints hypothesis, showing that, while key biophysical factors must coincide for wildfires to occur, the relative influence of resources to burn and moisture/weather conditions on fire activity shows predictable spatial patterns. In areas where resources are always available for burning during the fire season, such as subtropical/tropical biomes with mid-high annual long-term net primary productivity, fuel moisture conditions exert their strongest constraint on fire activity. In areas where resources are more limiting or variable, such as deserts, xeric shrublands, or grasslands/savannas, fuel moisture has a diminished constraint on wildfire, and metrics indicating availability of burnable fuels produced during the antecedent wet growing seasons reflect a more pronounced constraint on wildfire. This macro-scaled evidence for spatially varying constraints provides a synthesis with studies performed at local and regional scales, enhances our understanding of fire as a global process, and indicates how sensitivity to future changes in temperature and precipitation may differ across the world.

  20. Education & Recycling: Educator's Waste Management Resource and Activity Guide 1994.

    ERIC Educational Resources Information Center

    California State Dept. of Conservation. Sacramento. Div. of Recycling.

    This activity guide for grades K-12 reinforces the concepts of recycling, reducing, and reusing through a series of youth-oriented activities. The guide incorporates a video-based activity, multiple session classroom activities, and activities requiring group participation and student conducted research. Constructivist learning theory was…

  1. Mitochondrial fragmentation in excitotoxicity requires ROCK activation.

    PubMed

    Martorell-Riera, Alejandro; Segarra-Mondejar, Marc; Reina, Manuel; Martínez-Estrada, Ofelia M; Soriano, Francesc X

    2015-01-01

    Mitochondria morphology constantly changes through fission and fusion processes that regulate mitochondrial function, and it therefore plays a prominent role in cellular homeostasis. Cell death progression is associated with mitochondrial fission. Fission is mediated by the mainly cytoplasmic Drp1, which is activated by different post-translational modifications and recruited to mitochondria to perform its function. Our research and other studies have shown that in the early moments of excitotoxic insult Drp1 must be nitrosylated to mediate mitochondrial fragmentation in neurons. Nonetheless, mitochondrial fission is a multistep process in which filamentous actin assembly/disassembly and myosin-mediated mitochondrial constriction play prominent roles. Here we establish that in addition to nitric oxide production, excitotoxicity-induced mitochondrial fragmentation also requires activation of the actomyosin regulator ROCK. Although ROCK1 has been shown to phosphorylate and activate Drp1, experiments using phosphor-mutant forms of Drp1 in primary cortical neurons indicate that in excitotoxic conditions, ROCK does not act directly on Drp1 to mediate fission, but may act on the actomyosin complex. Thus, these data indicate that a wider range of signaling pathways than those that target Drp1 are amenable to be inhibited to prevent mitochondrial fragmentation as therapeutic option.

  2. 30 CFR 585.617 - What activities require a revision to my SAP, and when will BOEM approve the revision?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What activities require a revision to my SAP... FACILITIES ON THE OUTER CONTINENTAL SHELF Plans and Information Requirements Activities Under An Approved Sap § 585.617 What activities require a revision to my SAP, and when will BOEM approve the revision? (a)...

  3. 30 CFR 585.617 - What activities require a revision to my SAP, and when will BOEM approve the revision?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What activities require a revision to my SAP... FACILITIES ON THE OUTER CONTINENTAL SHELF Plans and Information Requirements Activities Under An Approved Sap § 585.617 What activities require a revision to my SAP, and when will BOEM approve the revision? (a)...

  4. 30 CFR 585.617 - What activities require a revision to my SAP, and when will BOEM approve the revision?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What activities require a revision to my SAP... FACILITIES ON THE OUTER CONTINENTAL SHELF Plans and Information Requirements Activities Under An Approved Sap § 585.617 What activities require a revision to my SAP, and when will BOEM approve the revision? (a)...

  5. 30 CFR 285.617 - What activities require a revision to my SAP, and when will MMS approve the revision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What activities require a revision to my SAP... OUTER CONTINENTAL SHELF Plans and Information Requirements Activities Under An Approved Sap § 285.617 What activities require a revision to my SAP, and when will MMS approve the revision? (a) You...

  6. Piezoelectric Power Requirements for Active Vibration Control

    NASA Technical Reports Server (NTRS)

    Brennan, Matthew C.; McGowan, Anna-Maria Rivas

    1997-01-01

    This paper presents a method for predicting the power consumption of piezoelectric actuators utilized for active vibration control. Analytical developments and experimental tests show that the maximum power required to control a structure using surface-bonded piezoelectric actuators is independent of the dynamics between the piezoelectric actuator and the host structure. The results demonstrate that for a perfectly-controlled system, the power consumption is a function of the quantity and type of piezoelectric actuators and the voltage and frequency of the control law output signal. Furthermore, as control effectiveness decreases, the power consumption of the piezoelectric actuators decreases. In addition, experimental results revealed a non-linear behavior in the material properties of piezoelectric actuators. The material non- linearity displayed a significant increase in capacitance with an increase in excitation voltage. Tests show that if the non-linearity of the capacitance was accounted for, a conservative estimate of the power can easily be determined.

  7. Analyzing learning during Peer Instruction dialogues: A resource activation framework

    NASA Astrophysics Data System (ADS)

    Wood, Anna K.; Galloway, Ross K.; Hardy, Judy; Sinclair, Christine M.

    2014-12-01

    Peer Instruction (PI) is an evidence based pedagogy commonly used in undergraduate physics instruction. When asked questions designed to test conceptual understanding, it has been observed that the proportion of students choosing the correct answer increases following peer discussion; however, relatively little is known about what takes place during these discussions or how they are beneficial to the processes of learning physics [M. C. James and S. Willoughby, Am. J. Phys. 79, 123 (2011)]. In this paper a framework for analyzing PI discussions developed through the lens of the "resources model" [D. Hammer, Am. J. Phys. 64, 1316 (1996); D. Hammer et al., Information Age Publishing (2005)] is proposed. A central hypothesis for this framework is that the dialogue with peers plays a crucial role in activating appropriate cognitive resources, enabling the students to see the problem differently, and therefore to answer the questions correctly. This framework is used to gain greater insights into the PI discussions of first year undergraduate physics students at the University of Edinburgh, UK, which were recorded using Livescribe Smartpens. Analysis of the dialogues revealed three different types of resource activation corresponding to increasing cognitive grain size. These were activation of knowledge elements, activation of linkages between knowledge elements, and activation of control structures (epistemic games and epistemological frames). Three case studies are examined to illustrate the role that peer dialogue plays in the activation of these cognitive resources in a PI session. The implications for pedagogical practice are discussed.

  8. Functional requirements of computer systems for the U.S. Geological Survey, Water Resources Division, 1988-97

    USGS Publications Warehouse

    Hathaway, R.M.; McNellis, J.M.

    1989-01-01

    Investigating the occurrence, quantity, quality, distribution, and movement of the Nation 's water resources is the principal mission of the U.S. Geological Survey 's Water Resources Division. Reports of these investigations are published and available to the public. To accomplish this mission, the Division requires substantial computer technology to process, store, and analyze data from more than 57,000 hydrologic sites. The Division 's computer resources are organized through the Distributed Information System Program Office that manages the nationwide network of computers. The contract that provides the major computer components for the Water Resources Division 's Distributed information System expires in 1991. Five work groups were organized to collect the information needed to procure a new generation of computer systems for the U. S. Geological Survey, Water Resources Division. Each group was assigned a major Division activity and asked to describe its functional requirements of computer systems for the next decade. The work groups and major activities are: (1) hydrologic information; (2) hydrologic applications; (3) geographic information systems; (4) reports and electronic publishing; and (5) administrative. The work groups identified 42 functions and described their functional requirements for 1988, 1992, and 1997. A few new functions such as Decision Support Systems and Executive Information Systems, were identified, but most are the same as performed today. Although the number of functions will remain about the same, steady growth in the size, complexity, and frequency of many functions is predicted for the next decade. No compensating increase in the Division 's staff is anticipated during this period. To handle the increased workload and perform these functions, new approaches will be developed that use advanced computer technology. The advanced technology is required in a unified, tightly coupled system that will support all functions simultaneously

  9. Water resources activities in Kentucky, 1993-94

    USGS Publications Warehouse

    Maglothin, L. S.; Forbes, R.W.

    1994-01-01

    The U.S. Geological Survey (USGS) is the principal Federal water-resources data collection and investigation agency. Through the Water Resources Division District Office in Kentucky, the USGS investigates the occurrence, distribution, quantity, movement, and chemical and biological quality of surface and ground water in the State. The mission of this program is to collect, interpret, and publish information on water resources. Almost all research and data collection is a cooperative effort in which planning and financial support are shared by State and local agencies and governments. Other activities are funded by other Federal agencies or by direct Congressional appropriation. This report is intended to inform the public and cooperating agencies, vitally interested in the water resources of Kentucky, as to the current status of the Distfict's data collection and investigation program. Included in the report are summaries of water-resources activities in Kentucky conducted by the USGS. Also included is a description of the USGS mission and program, District organization, funding sources and cooperating agencies, and a list of USGS publications relevant to the water resources of the State.

  10. Board on Earth Sciences and Resources and its Activities

    NASA Technical Reports Server (NTRS)

    Schiffries, Craig M.

    1997-01-01

    The Board will provide oversight of the earth science and resource activities within the National Research Council, provide a review of research and public activities in the solid-earth sciences, and provide analyses and recommendations relevant to the supply, delivery, and associated impacts of and issues related to hydrocarbon, metallic, and non-metallic mineral resources. The Board will monitor the status of the earth sciences, assess the health of the disciplines, and identify research opportunities, and will respond to specific agency requests.

  11. Current water resources activities in Alabama, fiscal year 1986

    USGS Publications Warehouse

    Slack, L.J.; Meadows, E.A.

    1986-01-01

    The purpose of this report is to describe the current (as of 1986) water resources activities of the U.S. Geological Survey in Alabama. The responsibilities and objectives of the Survey; organization of the Alabama District; sources of funding; current projects; hydrologic data program; and a selected bibliography of hydrologic reports are presented. Water resources projects are undertaken usually at the request of and with partial funding from another agency, provided: they are high priority problems and generally identified to fall within the mission of the Water Resources Division and they are consistent with the Program Management Plan developed by the Water Resources Division in Alabama to meet the long range plan for hydrologic data in the State. (USGS)

  12. Resources

    MedlinePlus

    ... can be found on the web, through local libraries, your health care provider, and the yellow pages under "social service organizations." AIDS - resources Alcoholism - resources Allergy - resources ...

  13. MYST protein acetyltransferase activity requires active site lysine autoacetylation.

    PubMed

    Yuan, Hua; Rossetto, Dorine; Mellert, Hestia; Dang, Weiwei; Srinivasan, Madhusudan; Johnson, Jamel; Hodawadekar, Santosh; Ding, Emily C; Speicher, Kaye; Abshiru, Nebiyu; Perry, Rocco; Wu, Jiang; Yang, Chao; Zheng, Y George; Speicher, David W; Thibault, Pierre; Verreault, Alain; Johnson, F Bradley; Berger, Shelley L; Sternglanz, Rolf; McMahon, Steven B; Côté, Jacques; Marmorstein, Ronen

    2012-01-04

    The MYST protein lysine acetyltransferases are evolutionarily conserved throughout eukaryotes and acetylate proteins to regulate diverse biological processes including gene regulation, DNA repair, cell-cycle regulation, stem cell homeostasis and development. Here, we demonstrate that MYST protein acetyltransferase activity requires active site lysine autoacetylation. The X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins (yEsa1-K262 and hMOF-K274) in the enzyme active site. The structure of hMOF also shows partial occupancy of K274 in the unacetylated form, revealing that the side chain reorients to a position that engages the catalytic glutamate residue and would block cognate protein substrate binding. Consistent with the structural findings, we present mass spectrometry data and biochemical experiments to demonstrate that this lysine autoacetylation on yEsa1, hMOF and its yeast orthologue, ySas2 (KAT8) occurs in solution and is required for acetylation and protein substrate binding in vitro. We also show that this autoacetylation occurs in vivo and is required for the cellular functions of these MYST proteins. These findings provide an avenue for the autoposttranslational regulation of MYST proteins that is distinct from other acetyltransferases but draws similarities to the phosphoregulation of protein kinases.

  14. MYST protein acetyltransferase activity requires active site lysine autoacetylation

    PubMed Central

    Yuan, Hua; Rossetto, Dorine; Mellert, Hestia; Dang, Weiwei; Srinivasan, Madhusudan; Johnson, Jamel; Hodawadekar, Santosh; Ding, Emily C; Speicher, Kaye; Abshiru, Nebiyu; Perry, Rocco; Wu, Jiang; Yang, Chao; Zheng, Y George; Speicher, David W; Thibault, Pierre; Verreault, Alain; Johnson, F Bradley; Berger, Shelley L; Sternglanz, Rolf; McMahon, Steven B; Côté, Jacques; Marmorstein, Ronen

    2012-01-01

    The MYST protein lysine acetyltransferases are evolutionarily conserved throughout eukaryotes and acetylate proteins to regulate diverse biological processes including gene regulation, DNA repair, cell-cycle regulation, stem cell homeostasis and development. Here, we demonstrate that MYST protein acetyltransferase activity requires active site lysine autoacetylation. The X-ray crystal structures of yeast Esa1 (yEsa1/KAT5) bound to a bisubstrate H4K16CoA inhibitor and human MOF (hMOF/KAT8/MYST1) reveal that they are autoacetylated at a strictly conserved lysine residue in MYST proteins (yEsa1-K262 and hMOF-K274) in the enzyme active site. The structure of hMOF also shows partial occupancy of K274 in the unacetylated form, revealing that the side chain reorients to a position that engages the catalytic glutamate residue and would block cognate protein substrate binding. Consistent with the structural findings, we present mass spectrometry data and biochemical experiments to demonstrate that this lysine autoacetylation on yEsa1, hMOF and its yeast orthologue, ySas2 (KAT8) occurs in solution and is required for acetylation and protein substrate binding in vitro. We also show that this autoacetylation occurs in vivo and is required for the cellular functions of these MYST proteins. These findings provide an avenue for the autoposttranslational regulation of MYST proteins that is distinct from other acetyltransferases but draws similarities to the phosphoregulation of protein kinases. PMID:22020126

  15. 30 CFR 285.617 - What activities require a revision to my SAP, and when will MMS approve the revision?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What activities require a revision to my SAP... Activities Under An Approved Sap § 285.617 What activities require a revision to my SAP, and when will MMS... your approved SAP, describing in detail the type of activities you propose to conduct. We...

  16. A RESOURCE BOOK OF AEROSPACE ACTIVITIES, K-6.

    ERIC Educational Resources Information Center

    Lincoln Public Schools, NE.

    THIS RESOURCE BOOK OF ACTIVITIES WAS WRITTEN FOR TEACHERS OF GRADES K-6, TO HELP THEM INTEGRATE AEROSPACE SCIENCE WITH THE REGULAR LEARNING EXPERIENCES OF THE CLASSROOM. SUGGESTIONS ARE MADE FOR INTRODUCING AEROSPACE CONCEPTS INTO THE VARIOUS SUBJECT FIELDS SUCH AS LANGUAGE ARTS, MATHEMATICS, PHYSICAL EDUCATION, SOCIAL STUDIES, AND OTHERS. SUBJECT…

  17. Teacher's Resource Guide on Acidic Precipitation with Laboratory Activities.

    ERIC Educational Resources Information Center

    Barrow, Lloyd H.

    The purpose of this teacher's resource guide is to help science teachers incorporate the topic of acidic precipitation into their curricula. A survey of recent junior high school science textbooks found a maximum of one paragraph devoted to the subject; in addition, none of these books had any related laboratory activities. It was on the basis of…

  18. Learning for Change in World Society: Reflections, Activities and Resources.

    ERIC Educational Resources Information Center

    One World Trust, London (England).

    The resource booklet contains readings and activities for British secondary school world affairs classes. The material lends itself toward incorporation into various curricula, including history, geography, social studies, humanities, environmental studies, language and literature, home economics, math, and science. Subject matter focuses on…

  19. Suggestions, Resources and Activities for Teaching about Japan.

    ERIC Educational Resources Information Center

    Thomas, Paul F.

    This teacher resource packet contains a total of 28 modules for teaching about Japan at the elementary and secondary level. Activities on the Japanese family appropriate for grade 1 focus on similarities and differences, family size, family needs, and family roles. Grade 2 lessons look at the school, neighborhood, roles of children in the…

  20. Water Resource Uses and Recreational Activities in Rural Nigeria.

    ERIC Educational Resources Information Center

    Adekoya, Adebola

    1991-01-01

    This study surveys rural Nigerian residents concerning local water resource uses and tourists' recreational activities with respect to scales of awareness, understanding, and incentive. Results indicate a public willingness to encourage and finance the rural development of water bodies for agricultural purposes exclusive of investment for tourism…

  1. Community Resources for Promoting Youth Nutrition and Physical Activity

    ERIC Educational Resources Information Center

    Moore, Kelly R.; McGowan, Melissa K.; Donato, Karen A.; Kollipara, Sobha; Roubideaux, Yvette

    2009-01-01

    Childhood obesity is a national public health crisis. The National Diabetes Education Program (NDEP), the National Institutes of Health and Kaiser Permanente have developed community tools and resources for children and families to lower their risk for obesity through healthier, active lifestyles. The authors describe innovative practices and…

  2. The World of Business. Teacher's Activity and Resource Guide.

    ERIC Educational Resources Information Center

    Columbus Public Schools, OH.

    This activity and resource guide is intended to assist teachers in developing course content and effective teaching methods in business education. (General Business for Economic Understanding," 11th edition, is the adopted textbook for this guide.) The guide is organized into twelve major units and is designed so that each unit builds upon the…

  3. Board on Earth Sciences and Resources and its activities

    SciTech Connect

    de Souza, Dr. Anthony R.

    2000-02-23

    This 1999 annual report of the activities of the National Research Council's (NRC) Board on Earth Sciences and Resources (BESR) begins with an introduction to the Board. This report (1) lists activities of the Board sustained by Department of Energy support, (2) presents accomplishments of the Board, (3) describes current and proposed studies of the Board, and (4) provides a brief review of the Board's future plans.

  4. TERSSE: Definition of the Total Earth Resources System for the Shuttle Era. Volume 3: Mission and System Requirements for the Total Earth Resources System

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Resource management missions to be performed by TERSSE are described. Mission and user requirements are defined along with information flows developed for each major resource management mission. Other topics discussed include: remote sensing platforms, remote sensor requirements, ground system architecture, and such related issues as cloud cover, resolution, orbit mechanics, and aircraft versus satellite.

  5. Analysis of requirements for accelerating the development of geothermal energy resources in California

    NASA Technical Reports Server (NTRS)

    Fredrickson, C. D.

    1978-01-01

    Various resource data are presented showing that geothermal energy has the potential of satisfying a singificant part of California's increasing energy needs. General factors slowing the development of geothermal energy in California are discussed and required actions to accelerate its progress are presented. Finally, scenarios for developing the most promising prospects in the state directed at timely on-line power are given. Specific actions required to realize each of these individual scenarios are identified.

  6. Study of Nursing Manpower Requirements and Resources in Kentucky, 1981 and 1985. Kentucky Nursing Education Project.

    ERIC Educational Resources Information Center

    Kentucky State Council on Higher Education, Frankfort.

    The Kentucky Nursing Manpower Requirements and Resources Study (1981 and 1985) is one segment of a nursing project designed to develop a coordinated statewide system of nursing education in Kentucky. The study determined the number and types of nurses needed and compared current and anticipated nursing manpower supply and demand. Calculations of…

  7. Competencies Required of Human Resource Professionals in the Government Contracting Industry

    ERIC Educational Resources Information Center

    Boyer, Dawn Denise

    2013-01-01

    The purpose of this study was to determine if a unique set of Knowledge, Skills, and Abilities (KSAs) were required of Human Resource Practitioners (HRPs) in federal-level Government Contracting Companies (GCC) in the United States. Study results identified additional sets of HR-related KSAs to perform with minimum competency within a…

  8. South Carolina Commission on Higher Education Mission Resource Requirements (MRR), FY 2007-2008

    ERIC Educational Resources Information Center

    South Carolina Commission on Higher Education, 2007

    2007-01-01

    The Mission Resource Requirement (MRR) represents the level of funding necessary for an institution given its mission, size, and complexity of programs, based on regional and national norms, and the amount of the previous year's appropriation. This document is the MRR for the South Carolina Commission on Higher Education for Fiscal Year 2007-2008.…

  9. 32 CFR Enclosure 2 - Requirements for Environmental Considerations-Foreign Nations and Protected Global Resources

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of global importance designated for protection by the President or, in the case of such a resource... studies—bilateral or multilateral environmental studies, relevant or related to the proposed action, by... the procedures for the preparation of environmental studies or reviews when required by this...

  10. South Carolina Commission on Higher Education Mission Resource Requirement, FY 2005-2006

    ERIC Educational Resources Information Center

    South Carolina Commission on Higher Education, 2005

    2005-01-01

    The Mission Resource Requirement (MRR) represents the level of funding necessary for an institution given its mission, size, and complexity of programs, based on regional and national norms, and the amount of the previous year's appropriation. This document is the MRR for the South Carolina Commission on Higher Education for Fiscal Year 2005-2006.…

  11. Risk assessment activities at NIOSH: Information resources and needs

    SciTech Connect

    Stayner, L.T.; Meinhardt, T.; Hardin, B.

    1990-12-31

    Under the Occupational Safety and Health, and Mine Safety and Health Acts, the National Institute for Occupational Safety and Health (NIOSH) is charged with development of recommended occupational safety and health standards, and with conducting research to support the development of these standards. Thus, NIOSH has been actively involved in the analysis of risk associated with occupational exposures, and in the development of research information that is critical for the risk assessment process. NIOSH research programs and other information resources relevant to the risk assessment process are described in this paper. Future needs for information resources are also discussed.

  12. Idaho National Laboratory Cultural Resource Management Office FY 2011 Activity Report

    SciTech Connect

    Julie Braun Williams; Brenda R. Pace; Hollie K. Gilbert; Christina L. Olson

    2012-09-01

    The Idaho National Laboratory (INL) Site is home to vast numbers and a wide variety of important cultural resources representing at least a 13,500 year span of human land use in the region. As a federal agency, the Department of Energy, Idaho Operations Office (DOE-ID) has legal responsibility for the management and protection of the resources and has contracted these responsibilities to Battelle Energy Alliance (BEA). The BEA professional staff is committed to maintaining a cultural resource management program that accepts the challenge of preserving INL cultural resources in a manner reflecting their importance in local, regional, and national history. This report is intended as a stand-alone document that summarizes activities performed by the INL Cultural Resource Management Office (CRMO) staff during fiscal year 2011. This work is diverse, far-reaching and though generally confined to INL cultural resource compliance, also includes a myriad of professional and voluntary community activities. This document is intended to be informative to both internal and external stakeholders, serve as a planning tool for future INL cultural resource management work, and meet an agreed upon legal requirement.

  13. Technical guide on documentation requirements for open market contract acquisitions of information resources

    NASA Technical Reports Server (NTRS)

    Shaw, Asa L., Jr.; Kivett, William R.; Taylor, James Y.

    1990-01-01

    A guide is presented to assist requestors in formulating and submitting the required Complete Package for Information Resources (IR) acquisitions. Advance discussions with cognizant procurement personnel are strongly recommended for complex IR requirements or for those requestors new to the acquisition process. Open Market means the requirement either is not available on GSA Schedule Contract or exceeds the $300,000 threshold and/or the quantity Maximum Order Limitation of the GSA Schedule Contract. Only open market contract acquisitions (i.e., in excess of the $25,000 small purchase threshold), are addressed.

  14. Advanced Extravehicular Activity Pressure Garment Requirements Development

    NASA Technical Reports Server (NTRS)

    Ross, Amy

    2014-01-01

    The NASA Johnson Space Center advanced pressure garment technology development team is addressing requirements development for exploration missions. Lessons learned from the Z-2 high fidelity prototype development have reiterated that clear low-level requirements and verification methods reduce risk to the government, improve efficiency in pressure garment design efforts, and enable the government to be a smart buyer. The expectation is to provide requirements at the specification level that are validated so that their impact on pressure garment design is understood. Additionally, the team will provide defined verification protocols for the requirements. However, in reviewing exploration space suit high level requirements there are several gaps in the team's ability to define and verify related lower level requirements. This paper addresses the efforts in requirement areas such as mobility/fit/comfort and environmental protection (dust, radiation, plasma, secondary impacts) to determine the by what method the requirements can be defined and use of those methods for verification. Gaps exist at various stages. In some cases component level work is underway, but no system level effort has begun, in other cases no effort has been initiated to close the gap. Status of ongoing efforts and potential approaches to open gaps are discussed.

  15. Activities affecting surface water resources: A general overview

    SciTech Connect

    Not Available

    1990-01-01

    In November 1987, P.E.I. signed a federal/provincial work-sharing arrangement on water resource management focusing on groundwater pollution, surface water degradation and estuarine eutrophication. The surface water program was designed to identify current surface water uses and users within 12 major watersheds across the Island containing 26 individual rivers, as well as problems arising due to practices that degrade the quality of surface water and restricts its value to other user groups. This report presents a general overview of the program, covering the general characteristics of the Island; operations in agriculture, fish and wildlife, forestry, recreation, fisheries, and industry; alterations of natural features of waterways; wetlands; additional watershed activities such as hydrometric stations and subdivision development; and activities affecting surface water resources such as sedimentation sources, pollution point sources and instream obstructions.

  16. Ego depletion and positive illusions: does the construction of positivity require regulatory resources?

    PubMed

    Fischer, Peter; Greitemeyer, Tobias; Frey, Dieter

    2007-09-01

    Individuals frequently exhibit positive illusions about their own abilities, their possibilities to control their environment, and future expectations. The authors propose that positive illusions require resources of self-control, which is considered to be a limited resource similar to energy or strength. Five studies revealed that people with depleted self-regulatory resources indeed exhibited a less-optimistic sense of their own abilities (Study 1), a lower sense of subjective control (Study 2), and less-optimistic expectations about their future (Study 3). Two further studies shed light on the underlying psychological process: Ego-depleted (compared to nondepleted) individuals generated/retrieved less positive self-relevant attributes (Studies 4 and 5) and reported a lower sense of general self-efficacy (Study 5), which both partially mediated the impact of ego depletion on positive self-views (Study 5).

  17. Antiproliferative activity of synthetic fatty acid amides from renewable resources.

    PubMed

    dos Santos, Daiane S; Piovesan, Luciana A; D'Oca, Caroline R Montes; Hack, Carolina R Lopes; Treptow, Tamara G M; Rodrigues, Marieli O; Vendramini-Costa, Débora B; Ruiz, Ana Lucia T G; de Carvalho, João Ernesto; D'Oca, Marcelo G Montes

    2015-01-15

    In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer.

  18. Resource allocation in shared spectrum access communications for operators with diverse service requirements

    NASA Astrophysics Data System (ADS)

    Kibria, Mirza Golam; Villardi, Gabriel Porto; Ishizu, Kentaro; Kojima, Fumihide; Yano, Hiroyuki

    2016-12-01

    In this paper, we study inter-operator spectrum sharing and intra-operator resource allocation in shared spectrum access communication systems and propose efficient dynamic solutions to address both inter-operator and intra-operator resource allocation optimization problems. For inter-operator spectrum sharing, we present two competent approaches, namely the subcarrier gain-based sharing and fragmentation-based sharing, which carry out fair and flexible allocation of the available shareable spectrum among the operators subject to certain well-defined sharing rules, traffic demands, and channel propagation characteristics. The subcarrier gain-based spectrum sharing scheme has been found to be more efficient in terms of achieved throughput. However, the fragmentation-based sharing is more attractive in terms of computational complexity. For intra-operator resource allocation, we consider resource allocation problem with users' dissimilar service requirements, where the operator supports users with delay constraint and non-delay constraint service requirements, simultaneously. This optimization problem is a mixed-integer non-linear programming problem and non-convex, which is computationally very expensive, and the complexity grows exponentially with the number of integer variables. We propose less-complex and efficient suboptimal solution based on formulating exact linearization, linear approximation, and convexification techniques for the non-linear and/or non-convex objective functions and constraints. Extensive simulation performance analysis has been carried out that validates the efficiency of the proposed solution.

  19. Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis▿

    PubMed Central

    Korduláková, Jana; Janin, Yves L.; Liav, Avraham; Barilone, Nathalie; Dos Vultos, Tiago; Rauzier, Jean; Brennan, Patrick J.; Gicquel, Brigitte; Jackson, Mary

    2007-01-01

    Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitory activity on the stearoyl-coenzyme A desaturase DesA3, but its enzymatic target(s) in the mycolic acid pathway remains to be identified. With the goal of elucidating the mode of action of ISO, we have isolated a number of spontaneous ISO-resistant mutants of M. tuberculosis and undertaken their genotypic characterization. We report here the characterization of a subset of these strains carrying mutations in the monooxygenase gene ethA. Through complementation studies, we demonstrate for the first time that the EthA-mediated oxidation of ISO is absolutely required for this prodrug to inhibit its lethal enzymatic target(s) in M. tuberculosis. An analysis of the metabolites resulting from the in vitro transformation of ISO by purified EthA revealed the occurrence of a formimidamide allowing the formulation of an activation pathway in which the oxidation of ISO catalyzed by EthA is followed by chemical transformations involving extrusion or elimination and, finally, hydrolysis. PMID:17785510

  20. How Much Will Be Enough? Assessing Changing Defense Strategies Implications for Army Resource Requirements

    DTIC Science & Technology

    2014-01-01

    Resource Requirements M. Wade Markel, Stuart E. Johnson, Carolyn Chu, David C. Gompert, Duncan Long, Anny Wong Prepared for the United States Army...the U.S. Army Training and 1 See Paul K. Davis, Stuart E. Johnson, Duncan Long, and David C. Gompert...hereafter as Davis et al., 2008. See also David C. Gompert, Paul K. Davis, Stuart E. Johnson, and Duncan Long, Analysis of Strategy and Strategies of

  1. 43 CFR 3275.18 - May BLM require me to test for byproducts associated with geothermal resource production?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... associated with geothermal resource production? 3275.18 Section 3275.18 Public Lands: Interior Regulations... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Conducting Utilization Operations § 3275.18 May BLM require me to test for byproducts associated with geothermal resource production? You must conduct any tests...

  2. 43 CFR 3275.18 - May BLM require me to test for byproducts associated with geothermal resource production?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... associated with geothermal resource production? 3275.18 Section 3275.18 Public Lands: Interior Regulations... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Conducting Utilization Operations § 3275.18 May BLM require me to test for byproducts associated with geothermal resource production? You must conduct any tests...

  3. 43 CFR 3275.18 - May BLM require me to test for byproducts associated with geothermal resource production?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... associated with geothermal resource production? 3275.18 Section 3275.18 Public Lands: Interior Regulations... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Conducting Utilization Operations § 3275.18 May BLM require me to test for byproducts associated with geothermal resource production? You must conduct any tests...

  4. 43 CFR 3275.18 - May BLM require me to test for byproducts associated with geothermal resource production?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... associated with geothermal resource production? 3275.18 Section 3275.18 Public Lands: Interior Regulations... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Conducting Utilization Operations § 3275.18 May BLM require me to test for byproducts associated with geothermal resource production? You must conduct any tests...

  5. 30 CFR 921.779 - Surface mining permit applications-minimum requirements for information on environmental resources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Surface mining permit applications-minimum requirements for information on environmental resources. 921.779 Section 921.779 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH...

  6. 42 CFR 441.56 - Required activities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Periodic Screening, Diagnosis, and Treatment (EPSDT) of Individuals Under Age 21 § 441.56 Required... obtain those services; (iii) That the services provided under the EPSDT program are without cost to...) Appropriate vision testing. (iv) Appropriate hearing testing. (v) Appropriate laboratory tests. (vi)...

  7. 42 CFR 441.56 - Required activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Periodic Screening, Diagnosis, and Treatment (EPSDT) of Individuals Under Age 21 § 441.56 Required... obtain those services; (iii) That the services provided under the EPSDT program are without cost to...) Appropriate vision testing. (iv) Appropriate hearing testing. (v) Appropriate laboratory tests. (vi)...

  8. 42 CFR 441.56 - Required activities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Periodic Screening, Diagnosis, and Treatment (EPSDT) of Individuals Under Age 21 § 441.56 Required... obtain those services; (iii) That the services provided under the EPSDT program are without cost to...) Appropriate vision testing. (iv) Appropriate hearing testing. (v) Appropriate laboratory tests. (vi)...

  9. 42 CFR 441.56 - Required activities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Periodic Screening, Diagnosis, and Treatment (EPSDT) of Individuals Under Age 21 § 441.56 Required... obtain those services; (iii) That the services provided under the EPSDT program are without cost to...) Appropriate vision testing. (iv) Appropriate hearing testing. (v) Appropriate laboratory tests. (vi)...

  10. 42 CFR 441.56 - Required activities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Periodic Screening, Diagnosis, and Treatment (EPSDT) of Individuals Under Age 21 § 441.56 Required... obtain those services; (iii) That the services provided under the EPSDT program are without cost to...) Appropriate vision testing. (iv) Appropriate hearing testing. (v) Appropriate laboratory tests. (vi)...

  11. Frequency requirements for active earth observation sensors

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The foundation and rationale for the selection of microwave frequencies for active remote sensing usage and for subsequent use in determination of sharing criteria and allocation strategies for the WARC-79 are presented.

  12. Bibliography on Multicultural Activities in the Classroom: A Listing of Resources.

    ERIC Educational Resources Information Center

    Brady, Mary Lou; Geile, Carole

    This bibliography contains information on multicultural activities in the classroom. It is divided into three sections: a list of 97 book resources, a list of 59 journal articles, and a list of 17 ERIC (Educational Resources Information Center) resources. The resources include general multicultural teaching guides and specific topical resources:…

  13. Disulfide Bond Requirements for Active Wnt Ligands*

    PubMed Central

    MacDonald, Bryan T.; Hien, Annie; Zhang, Xinjun; Iranloye, Oladoyin; Virshup, David M.; Waterman, Marian L.; He, Xi

    2014-01-01

    Secreted Wnt lipoproteins are cysteine-rich and lipid-modified morphogens that bind to the Frizzled (FZD) receptor and LDL receptor-related protein 6 (LRP6). Wnt engages FZD through protruding thumb and index finger domains, which are each assembled from paired β strands secured by disulfide bonds and grasp two sides of the FZD ectodomain. The importance of Wnt disulfide bonds has been assumed but uncharacterized. We systematically analyzed cysteines and associated disulfide bonds in the prototypic Wnt3a. Our data show that mutation of any individual cysteine of Wnt3a results in covalent Wnt oligomers through ectopic intermolecular disulfide bond formation and diminishes/abolishes Wnt signaling. Although individual cysteine mutations in the amino part of the saposin-like domain and in the base of the index finger are better tolerated and permit residual Wnt3a secretion/activity, those in the amino terminus, the thumb, and at the tip of the index finger are incompatible with secretion and/or activity. A few select double cysteine mutants based on the disulfide bond pattern restore Wnt secretion/activity. Further, a double cysteine mutation at the index finger tip results in a Wnt3a with normal secretion but minimal FZD binding and dominant negative properties. Our results experimentally validate predictions from the Wnt crystal structure and highlight critical but different roles of the saposin-like and cytokine-like domains, including the thumb and the index finger in Wnt folding/secretion and FZD binding. Finally, we modified existing expression vectors for 19 epitope-tagged human WNT proteins by removal of a tag-supplied ectopic cysteine, thereby generating tagged WNT ligands active in canonical and non-canonical signaling. PMID:24841207

  14. 30 CFR 585.800 - How must I conduct my activities to comply with safety and environmental requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false How must I conduct my activities to comply with... for Activities Conducted Under SAPs, COPs and GAPs § 585.800 How must I conduct my activities to comply with safety and environmental requirements? (a) You must conduct all activities on your lease...

  15. 30 CFR 585.800 - How must I conduct my activities to comply with safety and environmental requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false How must I conduct my activities to comply with... for Activities Conducted Under SAPs, COPs and GAPs § 585.800 How must I conduct my activities to comply with safety and environmental requirements? (a) You must conduct all activities on your lease...

  16. 30 CFR 585.800 - How must I conduct my activities to comply with safety and environmental requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false How must I conduct my activities to comply with... for Activities Conducted Under SAPs, COPs and GAPs § 585.800 How must I conduct my activities to comply with safety and environmental requirements? (a) You must conduct all activities on your lease...

  17. Board on Earth Sciences and Resources and its activities

    SciTech Connect

    1995-06-01

    The Board on Earth Sciences and Resources (BESR) coordinates, the National Research Council`s advice to the federal government on solid-earth science issues. The board identifies opportunities for advancing basic research and understanding, reports on applications of earth sciences in such areas as disaster mitigation and resource utilization, and analyzes the scientific underpinnings and credibility of earth science information for resource, environmental and other applications and policy decision. Committees operating under the guidance of the Board conducts studies addressing specific issues within the earth sciences. The current committees are as follows: Committee on Geophysical and Environmental Data; Mapping Sciences Committee; Committee on Seismology; Committee on Geodesy; Rediscovering Geography Committee; Committee on Research Programs of the US Bureau of Mines. The following recent reports are briefly described: research programs of the US Bureau of Mines, first assessment 1994; Mount Rainier, active cascade volcano; the national geomagnetic initiative; reservoir class field demonstration program; solid-earth sciences and society; data foundation for the national spatial infrastructure; promoting the national spatial data infrastructure through partnerships; toward a coordinated spatial data infrastructure for the nation; and charting a course into the digital era; guidance to the NOAA`s nautical charting mission.

  18. Elementary school aerospace activities: A resource for teachers

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The chronological development of the story of man and flight, with emphasis on space flight, is presented in 10 units designed as a resource for elementary school teachers. Future exploration of space and the utlization of space flight capabilities are included. Each unit contains an outline, a list of suggested activities for correlation, a bibliography, and a list of selected audiovisual materials. A glossary of aerospace terms is included. Topics cover: earth characteristics that affect flight; flight in atmosphere, rockets, technological advances, unmanned Earth satellites, umanned exploration of the solar system, life support systems; astronauts, man in space, and projections for the future.

  19. The Gaia mission a rich resource for outreach activities

    NASA Astrophysics Data System (ADS)

    O'Flaherty, K. S.; Douglas, J.; Prusti, T.

    2008-07-01

    Space science missions, and astronomy missions in particular, capture the public imagination at all levels. ESA's Gaia mission is no exception to this. In addition to its key scientific goal of providing new insight into the origin, formation, and evolution of the Milky Way, Gaia also touches on many other scientific topics of broad appeal, for example, solar system objects, stars (including rare and exotic ones), dark matter, gravitational light bending. The mission naturally provides a rich resource for outreach possibilities whether it be to the general public, or to specific interest groups, such as scientists from other fields or educators. We present some examples of possible outreach activities for Gaia.

  20. Water Requirements for Energy Production Technologies: A Collaborative Effort to Support Integrated Resource Planning

    NASA Astrophysics Data System (ADS)

    Averyt, K.; Macknick, J.; Participants in The WaterEnergy Workshop

    2010-12-01

    Global, national and regional concerns are emerging about the capacity of available water resources to meet increasing energy demands posed by a growing population—particularly as water availability is expected to shift as a result of a warming climate. For the same reasons, the use of both non-traditional water resources and water transport is expected to increase, creating greater demand for energy to move and treat water. Integrated planning efforts designed to avoid collisions between water and energy resource management decisions require consistent data outlining both the water requirements for energy development, and the energy required to move and treat water. Here we present the results of a collaborative, interagency effort to compile, assess, and outline consumptive uses of water associated with different parts of the energy generation process. A consistent set of data is important to support integrated modeling efforts in support of decision making and planning. The leaders of several efforts occurring in parallel to collate water use data converged at a workshop held in August 2010. The participants shared estimates of water use related to the major water-consuming steps of all the energy production processes currently operating in the U.S., and those expected to be online in the future. Discussions also addressed underlying data assumptions, data reliability concerns, and regional variability in reported ranges of values. Participants identified key data gaps, determining whether outside expert engagement could fill the gaps, or if additional research was required. The team collaborated after the meeting to fill in the data gaps utilizing institutional knowledge from a wide variety of agencies. The end result is a compilation of best estimates of the water requirements for energy production, as agreed to by the expert participants at the workshop and subsequent interactions. One key informational gap emerging from the workshop is the need to

  1. T cell activation requires force generation

    PubMed Central

    Hu, Kenneth H.

    2016-01-01

    Triggering of the T cell receptor (TCR) integrates both binding kinetics and mechanical forces. To understand the contribution of the T cell cytoskeleton to these forces, we triggered T cells using a novel application of atomic force microscopy (AFM). We presented antigenic stimulation using the AFM cantilever while simultaneously imaging with optical microscopy and measuring forces on the cantilever. T cells respond forcefully to antigen after calcium flux. All forces and calcium responses were abrogated upon treatment with an F-actin inhibitor. When we emulated the forces of the T cell using the AFM cantilever, even these actin-inhibited T cells became activated. Purely mechanical stimulation was not sufficient; the exogenous forces had to couple through the TCR. These studies suggest a mechanical–chemical feedback loop in which TCR-triggered T cells generate forceful contacts with antigen-presenting cells to improve access to antigen. PMID:27241914

  2. 30 CFR 585.655 - What activities require a revision to my GAP, and when will BOEM approve the revision?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What activities require a revision to my GAP, and when will BOEM approve the revision? 585.655 Section 585.655 Mineral Resources BUREAU OF OCEAN... may begin the appropriate NEPA analysis and any relevant consultations when we determine that...

  3. 30 CFR 585.634 - What activities require a revision to my COP, and when will BOEM approve the revision?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What activities require a revision to my COP, and when will BOEM approve the revision? 585.634 Section 585.634 Mineral Resources BUREAU OF OCEAN... by BOEM. (d) We may begin the appropriate NEPA analysis and relevant consultations when we...

  4. 30 CFR 280.3 - What requirements must I follow when I conduct prospecting or research activities?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What requirements must I follow when I conduct prospecting or research activities? 280.3 Section 280.3 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE PROSPECTING FOR MINERALS OTHER THAN OIL, GAS, AND SULPHUR ON THE...

  5. 30 CFR 280.3 - What requirements must I follow when I conduct prospecting or research activities?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What requirements must I follow when I conduct prospecting or research activities? 280.3 Section 280.3 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE PROSPECTING FOR MINERALS OTHER THAN OIL,...

  6. Lunar in situ resource utilization by activated thermites

    NASA Astrophysics Data System (ADS)

    Hobosyan, Mkhitar; Martirosyan, Karen

    2011-10-01

    NASA's anticipated returns to the Moon by 2020, subsequent establishment of lunar in situ resource utilization technologies are essential. The surface of Moon is covered with small eroded particles of regolith called lunar dust that adheres electro-statically to everything coming in contact with it, and is of much concern for future lunar base because of its continual mitigation. The next major concern is the protection of equipment and personnel in long term expeditions from harmful UV radiation, which can be made by constructing protective buildings. For construction of permanent structures it is highly desired to have regular shaped sintered regolith with utilization of local materials and with minimum energy consumption. In this study the concept of sintering of lunar regolith with activated thermite reactions is discussed. The thermodynamic calculations as well as the experimental procedure is provided to prove the effectiveness of activated thermites for regolith sintering using local lunar resources with a low (15 wt. %) concentration of aluminum or magnesium. The thermite method is much more energy efficient than the other sintering methods suggested in literature.

  7. Integrating Natural Resource Damage Assessment and environmental restoration activities at DOE facilities

    SciTech Connect

    Bascietto, J.J.; Sharples, F.E.; Suter, G.W. II

    1993-06-01

    Environmental restoration activities are currently under way at several sites owned by the US Department of Energy (DOE) under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. DOE is the CERCLA lead response agency for these activities. Section 120(a) of the Superfund Amendments and Reauthorization Act also subjects DOE to liability under Section 107 of CERCLA for natural resource damages resulting from hazardous substance releases at its sites. The Natural Resource Damage Assessment (NRDA) process, by which natural resource injuries are determined and compensatory monetary damages are calculated, is not well known or understood by DOE staff and contractors involved in environmental restoration activities. Nevertheless, natural resource liabilities are potentially a significant source of additional monetary claims for CERCLA hazardous substance releases. This paper describes the requirements of NRDA and explains how to integrate the NRDA and CERCLA Remedial Investigation/Feasibility Study processes, in order to more quickly restore environmental services at the lowest total cost to the public. The first section of the paper explains the statutory and regulatory mandates for the NRDA process. The second section briefly describes the four phases of the NRDA process, while the third section examines the three steps in the assessment phase in considerable detail. Finally, the last section focuses on the integration of the CERCLA and NRDA processes.

  8. Water-resources activities in New England, fiscal year 1993

    USGS Publications Warehouse

    Orlando, M.F.

    1994-01-01

    The U.S. Geological Survey has 82 active or complete-except-report projects of hydrologic investigations ongoing within the New England Program Area. Of this total, 23 are data projects. Data projects contain statistics and data on the conditions of surface water, ground water, water quality and (or) water use for the study area. There currently are six data projects in Connecticut, five in Maine, four in Massachusetts, four in Rhode Island, and four in New Hampshire and Vermont. The remaining 59 of these projects are interpretive projects. Interpretive projects include research, aerial appraisal, and other hydrologic studies and include projects as diverse as (1) determining the direction of ground-water flow at a toxic site, (2) predicting the effect of acid rain on water quality of a reservoir, and (3) estimating yields of aquifers on Cape Cod. Of the interpretive projects, 26 are in Massachusetts, 17 in Connecticut, 17 are in New Hampshire and Vermont, 6 are in Maine, and 3 in Rhode Island. The report is compiled from project descriptions for fiscal year 1993. It briefly describes the water-resources activities and projects that were active in each District of the USGS, Water Resources Division, New England Program Area of September 30, 1993. Cooperator or funding source, problem statements, objectives, approaches, progress, and plans for next year are described for each project. The project area is located on a map of the appropriate State(s). The report contains a bibliography, by District and by author, of reports completed since 1977.

  9. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  10. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  11. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  12. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.507 Credit activity reporting requirements. (a) A...

  13. 27 CFR 40.526 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Minimum manufacturing and activity requirements. 40.526 Section 40.526 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Manufacturers of Processed Tobacco § 40.526 Minimum manufacturing and activity requirements. A permit...

  14. 27 CFR 40.256 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Minimum manufacturing and... Provisions Relating to Operations § 40.256 Minimum manufacturing and activity requirements. The minimum manufacturing and activity requirement prescribed in § 40.61(c) of this part is a continuing condition of...

  15. 27 CFR 40.526 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Minimum manufacturing and activity requirements. 40.526 Section 40.526 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Manufacturers of Processed Tobacco § 40.526 Minimum manufacturing and activity requirements. A permit...

  16. 27 CFR 40.256 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Minimum manufacturing and... Provisions Relating to Operations § 40.256 Minimum manufacturing and activity requirements. The minimum manufacturing and activity requirement prescribed in § 40.61(c) of this part is a continuing condition of...

  17. 27 CFR 40.256 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Minimum manufacturing and... Provisions Relating to Operations § 40.256 Minimum manufacturing and activity requirements. The minimum manufacturing and activity requirement prescribed in § 40.61(b) of this part is a continuing condition of...

  18. 27 CFR 40.526 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Minimum manufacturing and activity requirements. 40.526 Section 40.526 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Manufacturers of Processed Tobacco § 40.526 Minimum manufacturing and activity requirements. A permit...

  19. 27 CFR 40.526 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Minimum manufacturing and activity requirements. 40.526 Section 40.526 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Manufacturers of Processed Tobacco § 40.526 Minimum manufacturing and activity requirements. A permit...

  20. 27 CFR 40.256 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Minimum manufacturing and... Provisions Relating to Operations § 40.256 Minimum manufacturing and activity requirements. The minimum manufacturing and activity requirement prescribed in § 40.61(b) of this part is a continuing condition of...

  1. 27 CFR 40.526 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Minimum manufacturing and activity requirements. 40.526 Section 40.526 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Manufacturers of Processed Tobacco § 40.526 Minimum manufacturing and activity requirements. A permit...

  2. 27 CFR 40.256 - Minimum manufacturing and activity requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Minimum manufacturing and... Provisions Relating to Operations § 40.256 Minimum manufacturing and activity requirements. The minimum manufacturing and activity requirement prescribed in § 40.61(b) of this part is a continuing condition of...

  3. Reasoning abstractly about resources

    NASA Technical Reports Server (NTRS)

    Clement, B.; Barrett, A.

    2001-01-01

    r describes a way to schedule high level activities before distributing them across multiple rovers in order to coordinate the resultant use of shared resources regardless of how each rover decides how to perform its activities. We present an algorithm for summarizing the metric resource requirements of an abstract activity based n the resource usages of its potential refinements.

  4. Resource Letter ALIP-1: Active-Learning Instruction in Physics

    NASA Astrophysics Data System (ADS)

    Meltzer, David E.; Thornton, Ronald K.

    2012-06-01

    This Resource Letter provides a guide to the literature on research-based active-learning instruction in physics. These are instructional methods that are based on, assessed by, and validated through research on the teaching and learning of physics. They involve students in their own learning more deeply and more intensely than does traditional instruction, particularly during class time. The instructional methods and supporting body of research reviewed here offer potential for significantly improved learning in comparison to traditional lecture-based methods of college and university physics instruction. We begin with an introduction to the history of active learning in physics in the United States, and then discuss some methods for and outcomes of assessing pedagogical effectiveness. We enumerate and describe common characteristics of successful active-learning instructional strategies in physics. We then discuss a range of methods for introducing active-learning instruction in physics and provide references to those methods for which there is published documentation of student learning gains.

  5. Beyond emotional benefits: physical activity and sedentary behaviour affect psychosocial resources through emotions.

    PubMed

    Hogan, Candice L; Catalino, Lahnna I; Mata, Jutta; Fredrickson, Barbara L

    2015-01-01

    Physical activity is known to improve emotional experiences, and positive emotions have been shown to lead to important life outcomes, including the development of psychosocial resources. In contrast, time spent sedentary may negatively impact emotional experiences and, consequently, erode psychosocial resources. Two studies tested whether activity independently influenced emotions and psychosocial resources, and whether activity indirectly influenced psychosocial resources through emotional experiences. Using cross-sectional (Study 1a) and longitudinal (Study 1b) methods, we found that time spent physically active independently predicted emotions and psychosocial resources. Mediation analyses suggested that emotions may account for the relation between activity and psychosocial resources. The improved emotional experiences associated with physical activity may help individuals build psychosocial resources known to improve mental health. Study 1a provided first indicators to suggest that, in contrast, sedentary behaviour may reduce positive emotions, which could in turn lead to decrements in psychosocial resources.

  6. Active Learning Techniques Applied to an Interdisciplinary Mineral Resources Course.

    NASA Astrophysics Data System (ADS)

    Aird, H. M.

    2015-12-01

    An interdisciplinary active learning course was introduced at the University of Puget Sound entitled 'Mineral Resources and the Environment'. Various formative assessment and active learning techniques that have been effective in other courses were adapted and implemented to improve student learning, increase retention and broaden knowledge and understanding of course material. This was an elective course targeted towards upper-level undergraduate geology and environmental majors. The course provided an introduction to the mineral resources industry, discussing geological, environmental, societal and economic aspects, legislation and the processes involved in exploration, extraction, processing, reclamation/remediation and recycling of products. Lectures and associated weekly labs were linked in subject matter; relevant readings from the recent scientific literature were assigned and discussed in the second lecture of the week. Peer-based learning was facilitated through weekly reading assignments with peer-led discussions and through group research projects, in addition to in-class exercises such as debates. Writing and research skills were developed through student groups designing, carrying out and reporting on their own semester-long research projects around the lasting effects of the historical Ruston Smelter on the biology and water systems of Tacoma. The writing of their mini grant proposals and final project reports was carried out in stages to allow for feedback before the deadline. Speakers from industry were invited to share their specialist knowledge as guest lecturers, and students were encouraged to interact with them, with a view to employment opportunities. Formative assessment techniques included jigsaw exercises, gallery walks, placemat surveys, think pair share and take-home point summaries. Summative assessment included discussion leadership, exams, homeworks, group projects, in-class exercises, field trips, and pre-discussion reading exercises

  7. Creating the spatial framework for National Aquatic Resource Surveys (NARS): Melding National Aquatic Data Sets with Survey Requirements

    EPA Science Inventory

    The U.S. EPA’s National Aquatic Resource Surveys (NARS) require a consistent spatial representation of the resource target populations being monitored (i.e., rivers and streams, lakes, coastal waters, and wetlands). A sample frame is the GIS representation of this target popula...

  8. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive...

  9. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive...

  10. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive...

  11. 48 CFR 3004.470 - Security requirements for access to unclassified facilities, Information Technology resources...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... access to unclassified facilities, Information Technology resources, and sensitive information. 3004.470... Technology resources, and sensitive information. ... ACQUISITION REGULATION (HSAR) GENERAL ADMINISTRATIVE MATTERS Safeguarding Classified and Sensitive...

  12. KC-46 Workforce Requirements for Depot Maintenance Activation

    DTIC Science & Technology

    2014-03-27

    as International Standard for Organization ( ISO 9001 ) rating, and Aerospace Standards (AS 9100) rating (International Organization for...crew chief wages, management wages, purchasing activities, engineering activities, stock handlers wages, production control activities, quality ... Managment 5, 105-112. G-14 Americas Aerospace Quality Standards Committee . (2009, January 15). Quality Management Systems - Requirements for

  13. Requirements for Planetary Outpost Life-Support Systems and the Possible Use of In Situ Resources

    NASA Technical Reports Server (NTRS)

    Gruener, John E.; Ming, D. W.

    1998-01-01

    If humans are ever to live and work on the Moon or Mars for extended periods of time, the operation of regenerative life-support systems at the planetary outposts will be a critical requirement. The substantial amount of materials consumed by humans and the inevitable waste products make open-loop life-support systems and resupply missions (as used in Space Shuttle and Mir operations) impractical and expensive. Natural resources found on the Moon and Mars could be used in conjunction with regenerative life support systems to further reduce the amount of material that would need to be delivered from Earth. There have been numerous studies and experiments conducted on the production of O from regolith materials on the Moon and from the atmosphere of Mars. One or several of these processes could undoubtedly be used to produce the O required by the crews at planetary outposts. Water is required in the greatest quantities, primarily for tasks such as personal hygiene and clothes washing, and it will be the most precious consumable. Again, several process have been described to produce water on the Moon using solar-wind implanted H and O, and if water ice can be found and mined at the lunar poles, another source of water may be available.

  14. Space Resource Requirements for Future In-Space Propellant Production Depots

    NASA Technical Reports Server (NTRS)

    Smitherman, David; Fikes, John; Roy, Stephanie; Henley, Mark W.; Potter, Seth D.; Howell, Joe T. (Technical Monitor)

    2001-01-01

    In 2000 and 2001 studies were conducted at the NASA Marshall Space Flight Center on the technical requirements and commercial potential for propellant production depots in low Earth orbit (LEO) to support future commercial, NASA, and other Agency missions. Results indicate that propellant production depots appear to be technically feasible given continued technology development, and there is a substantial growing market that depots could support. Systems studies showed that the most expensive part of transferring payloads to geosynchronous orbit (GEO) is the fuel. A cryogenic propellant production and storage depot stationed in LEO could lower the cost of missions to GEO and beyond. Propellant production separates water into hydrogen and oxygen through electrolysis. This process utilizes large amounts of power, therefore a depot derived from advanced space solar power technology was defined. Results indicate that in the coming decades there could be a significant demand for water-based propellants from Earth, moon, or asteroid resources if in-space transfer vehicles (upper stages) transitioned to reusable systems using water based propellants. This type of strategic planning move could create a substantial commercial market for space resources development, and ultimately lead toward significant commercial infrastructure development within the Earth-Moon system.

  15. 25 CFR 161.200 - Is an Indian agricultural resource management plan required?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... goals and objectives in the agricultural resource management plan developed by the Navajo Nation, or by... resources; (2) Identify specific tribal agricultural resource goals and objectives; (3) Establish management... resource management objectives; and (5) Identify actions to be taken to reach established objectives....

  16. Hardware vs. Manpower Comparability Methodology. Volume 5. Step 4: Training Resource Requirements Analysis

    DTIC Science & Technology

    1990-05-01

    AD- A225 748 *ZsQ OTIC FILE COPY Research Product 90-19E Hardware vs. Manpower Comparability Methodology Step 4: Training Resource Requirements...E Zo o 0Lw0 CL Cr C 0a Lu u0 ci 0. C13 0 00 _ zD CO 0 C Oua = 0 0. Lu a) E z *o c h. - U * c am. E z 0 (0 I o D co0 cc zo 0- .0 a ) qe Y0 a. E. - V 0...4.2-29 SUBSTEP 4.2 WORKSHEETS 4.2-31 z 0. ILI V o a Cr CLC E _ _ _ _ _ 0 s1 c* CA = 0) 0 cc2 0 0 v. w 3 ow z 04 4. -W - 0Z oo~ C 00 4.-3 A C0C 2 c

  17. 78 FR 8192 - Agency Information Collection Activities: Comment Request; Education and Human Resources Project...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION Agency Information Collection Activities: Comment Request; Education and Human Resources Project... study will assess the implementation of resources, models, and technologies to determine how and...

  18. 20 CFR 655.1302 - Required pre-filing activity.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Employment in the United States (H-2A Workers) § 655.1302 Required pre-filing activity. (a) Time of filing of... requirements for H-2ALCs are set forth in § 655.106. (b) General attestation obligation. An employer must... as specified in this section. (c) Retention of documentation. An employer filing an Application...

  19. 10 CFR 30.3 - Activities requiring license.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... that possesses and uses accelerator-produced radioactive material or discrete sources of radium-226 for...-produced radioactive material or discrete sources of radium-226 for which a specific license is required in... sources of radium-226 for which a license amendment is required to authorize the activities in...

  20. 10 CFR 30.3 - Activities requiring license.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... that possesses and uses accelerator-produced radioactive material or discrete sources of radium-226 for...-produced radioactive material or discrete sources of radium-226 for which a specific license is required in... sources of radium-226 for which a license amendment is required to authorize the activities in...

  1. 10 CFR 30.3 - Activities requiring license.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... that possesses and uses accelerator-produced radioactive material or discrete sources of radium-226 for...-produced radioactive material or discrete sources of radium-226 for which a specific license is required in... sources of radium-226 for which a license amendment is required to authorize the activities in...

  2. 10 CFR 30.3 - Activities requiring license.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... that possesses and uses accelerator-produced radioactive material or discrete sources of radium-226 for...-produced radioactive material or discrete sources of radium-226 for which a specific license is required in... sources of radium-226 for which a license amendment is required to authorize the activities in...

  3. 10 CFR 30.3 - Activities requiring license.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... that possesses and uses accelerator-produced radioactive material or discrete sources of radium-226 for...-produced radioactive material or discrete sources of radium-226 for which a specific license is required in... sources of radium-226 for which a license amendment is required to authorize the activities in...

  4. 33 CFR 324.3 - Activities requiring permits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... effluent limitations and water quality standards from state or interstate water pollution control agencies..., DEPARTMENT OF DEFENSE PERMITS FOR OCEAN DUMPING OF DREDGED MATERIAL § 324.3 Activities requiring permits. (a) General. DA permits are required for the transportation of dredged material for the purpose of dumping...

  5. 33 CFR 324.3 - Activities requiring permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... effluent limitations and water quality standards from state or interstate water pollution control agencies..., DEPARTMENT OF DEFENSE PERMITS FOR OCEAN DUMPING OF DREDGED MATERIAL § 324.3 Activities requiring permits. (a) General. DA permits are required for the transportation of dredged material for the purpose of dumping...

  6. 33 CFR 324.3 - Activities requiring permits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... effluent limitations and water quality standards from state or interstate water pollution control agencies..., DEPARTMENT OF DEFENSE PERMITS FOR OCEAN DUMPING OF DREDGED MATERIAL § 324.3 Activities requiring permits. (a) General. DA permits are required for the transportation of dredged material for the purpose of dumping...

  7. Levee Safety: Army Corps and FEMA Have Made Little Progress in Carrying Out Required Activities

    DTIC Science & Technology

    2016-07-01

    damage from the hurricane cost the federal government more than $16 billion in disaster relief, according to data from the Federal Emergency Management ...Emergency Management Agency (FEMA) have made little progress in implementing key national levee-safety-related activities required in the Water Resources...Emergency Management Agency (FEMA) information. | GAO-16-709 View GAO-16-709. For more information- contact Anne-Marie Fennell at (202) 512-3841 or

  8. Resources.

    ERIC Educational Resources Information Center

    Aviation/Space, 1980

    1980-01-01

    The resources listed different types of materials related to the aerospace science under specified categories: free materials and inexpensive, selected government publication, audiovisual (government, nongovernment), aviation books, and space books. The list includes the publisher's name and the price for each publication. (SK)

  9. 33 CFR 324.3 - Activities requiring permits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., DEPARTMENT OF DEFENSE PERMITS FOR OCEAN DUMPING OF DREDGED MATERIAL § 324.3 Activities requiring permits. (a... in ocean waters. (b) Activities of Federal agencies. (1) The transportation of dredged material for the purpose of disposal in ocean waters done by or on behalf of any Federal agency other than...

  10. 33 CFR 324.3 - Activities requiring permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF DEFENSE PERMITS FOR OCEAN DUMPING OF DREDGED MATERIAL § 324.3 Activities requiring permits. (a... in ocean waters. (b) Activities of Federal agencies. (1) The transportation of dredged material for the purpose of disposal in ocean waters done by or on behalf of any Federal agency other than...

  11. 10 CFR 490.507 - Credit activity reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Credit activity reporting requirements. 490.507 Section 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM... activity report by the December 31 after the close of a model year to the Office of Energy Efficiency...

  12. 33 CFR Appendix B to Part 155 - Determining and Evaluating Required Response Resources for Vessel Response Plans

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... or operator must refer to the applicable Area Contingency Plan to determine if ice, debris, and... required capacity exceeds the applicable cap described in Table 6 of this appendix, then a vessel owner or operator must contract only for the quantity of resources required to meet the cap, but must...

  13. 42 CFR 435.220 - Individuals who would meet the income and resource requirements under AFDC if child care costs...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... requirements under AFDC if child care costs were paid from earnings. 435.220 Section 435.220 Public Health... AMERICAN SAMOA Options for Coverage as Categorically Needy Options for Coverage of Families and Children § 435.220 Individuals who would meet the income and resource requirements under AFDC if child care...

  14. UML activity diagrams in requirements specification of logic controllers

    NASA Astrophysics Data System (ADS)

    Grobelna, Iwona; Grobelny, Michał

    2015-12-01

    Logic controller specification can be prepared using various techniques. One of them is the wide understandable and user-friendly UML language and its activity diagrams. Using formal methods during the design phase increases the assurance that implemented system meets the project requirements. In the approach we use the model checking technique to formally verify a specification against user-defined behavioral requirements. The properties are usually defined as temporal logic formulas. In the paper we propose to use UML activity diagrams in requirements definition and then to formalize them as temporal logic formulas. As a result, UML activity diagrams can be used both for logic controller specification and for requirements definition, what simplifies the specification and verification process.

  15. Carp thrombocyte phagocytosis requires activation factors secreted from other leukocytes.

    PubMed

    Nagasawa, Takahiro; Somamoto, Tomonori; Nakao, Miki

    2015-10-01

    Thrombocytes are nucleated blood cells in non-mammalian vertebrates, which were recently focused on not only as hemostatic cells but also as immune cells with potent phagocytic activities. We have analyzed the phagocytic activation mechanisms in common carp (Cyprinus carpio) thrombocytes. MACS-sorted mAb(+) thrombocytes showed no phagocytic activity even in the presence of several stimulants. However, remixing these thrombocytes with other anti-thrombocyte mAb(-) leukocyte populations restored their phagocytic activities, indicating that carp thrombocyte phagocytosis requires an appropriate exogenous stimulation. Culture supernatant from anti-thrombocyte mAb(-) leukocytes harvested after PMA or LPS stimulation, but not culture supernatant from unstimulated leukocytes, could activate thrombocyte phagocytosis. This proposed mechanism of thrombocyte phagocytosis activation involving soluble factors produced by activated leukocytes suggests that thrombocyte activation is restricted to areas proximal to injured tissues, ensuring suppression of excessive thrombocyte activation and a balance between inflammation and tissue repair.

  16. Busy Teachers: A Case of Comparing Online Teacher-Created Activities with the Ready-Made Activity Resource Books

    ERIC Educational Resources Information Center

    Khoshhal, Yasin

    2016-01-01

    With the ever-growing needs for more resources, the lack of concentration on preparing an exclusive activity for a particular classroom can be observed in a large number of educational contexts. The present study investigates the efficiency of ready-made activities for busy teachers. To this end, an activity from the ready-made resource book,…

  17. Advanced Marketing 8130. Instructional Areas. Duties and Tasks. Learning Activities. Referenced Resources.

    ERIC Educational Resources Information Center

    Virginia State Dept. of Education, Richmond.

    This resource handbook, which is designed for use by instructors of courses in advanced marketing, consists of a duty/task list with referenced resources, a duty/task list with learning activities, and a list of resources. Included in each list are materials dealing with the following topics: communication in marketing, economics in marketing,…

  18. Life Sciences: Curriculum Resources and Activities for School Librarians and Teachers.

    ERIC Educational Resources Information Center

    Bain, Amy; Richer, Janet; Weckman, Janet

    This book provides resources to teachers and librarians for creating thematic units on specific topics targeting grades K-8. Each topic includes key concepts, comprehensive teaching resources, teaching resources (nonfiction children's literature), reading selections (fiction children's literature), science activities, creative writing and art…

  19. The Role of Learned Resourcefulness in Helping Female Undergraduates Deal with Unwanted Sexual Activity

    ERIC Educational Resources Information Center

    Kennett, Deborah J.; Humphreys, Terry P.; Patchell, Meghan

    2009-01-01

    We examined the relationship between learned resourcefulness skills and the manner in which undergraduate heterosexual women handle unwanted sexual advances/activity. Participants consisted of 150 females completing a set of questionnaires assessing general learned resourcefulness, sexual giving-in experience, sexual resourcefulness, sexual…

  20. Physical Sciences: Curriculum Resources and Activities for School Librarians and Teachers.

    ERIC Educational Resources Information Center

    Bain, Amy; Richer, Janet; Weckman, Janet

    This book provides resources to teachers and librarians for creating thematic units on specific topics targeting grades K-8. Each topic includes key concepts, comprehensive teaching resources, teaching resources (nonfiction children's literature), reading selections (fiction children's literature), science activities, creative writing and art…

  1. Earth Sciences: Curriculum Resources and Activities for School Librarians and Teachers.

    ERIC Educational Resources Information Center

    Bain, Amy; Richer, Janet; Weckman, Janet

    This book provides resources to teachers and librarians for creating thematic units on specific topics targeting grades K-8. Each topic includes key concepts, comprehensive teaching resources, teaching resources (nonfiction children's literature), reading selections (fiction children's literature), science activities, creative writing and art…

  2. TERSSE: Definition of the Total Earth Resources System for the Shuttle Era. Volume 5: Detailed system requirements: Two case studies

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Major resource management missions to be performed by the TERSSE are examined in order to develop an understanding of the form and function of a system designed to perform an operational mission. Factors discussed include: resource manager (user) functions, methods of performing their function, the information flows and information requirements embodied in their function, and the characteristics of the observation system which assists in the management of the resource involved. The missions selected for study are: world crop survey and land resources management. These missions are found to represent opposite ends of the TERSSE spectrum and to support the conclusion that different missions require different systems and must be analyzed in detail to permit proper system development decisions.

  3. The effects of task difficulty and resource requirements on attention strategies

    NASA Technical Reports Server (NTRS)

    King, Teresa

    1991-01-01

    The patterns of attention strategies for task difficulty/resource tasks for which experimental results are presented and analyzed support the hypothesis that subjects may adopt an alternating (rather than concurrent one) when compelled to do so by either the size or the complexity of a visual display. According to the multiple resource model, if subjects had been performing the two tasks concurrently, the cost of this strategy would have been shown by a decrement in the spatial format, rather than the verbal format, due to competition for the same resource. Subjects may apply different strategies as a function of task difficulty and/or resource demand.

  4. National BioResource Project-Rat and related activities.

    PubMed

    Serikawa, Tadao; Mashimo, Tomoji; Takizawa, Akiko; Okajima, Ryoko; Maedomari, Naoki; Kumafuji, Kenta; Tagami, Fumi; Neoda, Yuki; Otsuki, Mito; Nakanishi, Satoshi; Yamasaki, Ken-ichi; Voigt, Birger; Kuramoto, Takashi

    2009-07-01

    In order to establish a system to facilitate the systematic collection, preservation, and provision of laboratory rats (Rattus norvegicus) and their derivates, the National BioResource Project-Rat (NBRP-Rat) was launched in July 2002. By the end of 2008, more than 500 rat strains had been collected and preserved as live animals, embryos, or sperm. These rat resources are supplied to biomedical scientists in Japan as well as in other countries. This review article introduces NBRP-Rat and highlights the phenome project, recombinant inbred strains, BAC clone libraries, and the ENU-mutant archive, named the Kyoto University Rat Mutant Archive (KURMA). The future direction of rat resources are also discussed.

  5. Water-resources activities in New York, 1985-86

    USGS Publications Warehouse

    Finch, A. J.; Durocher, S.M.

    1986-01-01

    The U.S. Geologic Survey conducts water-resources investigations and hydrologic data collection in all states to provide the data and understanding needed for optimum use and management of the nation 's surface water and groundwater. This is achieved through jointly funded programs with state, county, municipal, and other Federal agencies. The Geological Survey conducted 37 water resources investigations in New York during 1985-86, several of which are continuous. This report describes each project in terms of problems, objectives, progress to date, and future plans and gives the period of funding, project chief, principal coordinating agency, field location, and completed reports. It also lists all reports resulting from the Survey 's water resources studies in New York during 1982-86. (USGS)

  6. 10 CFR 63.46 - Particular activities requiring license amendment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Particular activities requiring license amendment. 63.46 Section 63.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment §...

  7. 10 CFR 63.46 - Particular activities requiring license amendment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Particular activities requiring license amendment. 63.46 Section 63.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment §...

  8. 10 CFR 63.46 - Particular activities requiring license amendment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Particular activities requiring license amendment. 63.46 Section 63.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment §...

  9. 10 CFR 63.46 - Particular activities requiring license amendment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Particular activities requiring license amendment. 63.46 Section 63.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment §...

  10. 10 CFR 63.46 - Particular activities requiring license amendment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Particular activities requiring license amendment. 63.46 Section 63.46 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Licenses License Issuance and Amendment §...

  11. 20 CFR 655.1302 - Required pre-filing activity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Section 655.1302 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY EMPLOYMENT OF FOREIGN WORKERS IN THE UNITED STATES Labor Certification Process for Temporary Agricultural Employment in the United States (H-2A Workers) § 655.1302 Required pre-filing activity. (a) Time of filing...

  12. Requirements for extravehicular activities on the lunar and Martian surfaces

    NASA Technical Reports Server (NTRS)

    Brown, Mariann F.; Schentrup, Susan M.

    1990-01-01

    Basic design reference requirements pertinent to EVA equipment on lunar and martian surfaces are provided. Environmental factors affecting surface EVA are analyzed including gravity, dust, atmospheric conditions, thermal gradients, lightning conditions, and radiation effects, and activities associated with surface EVA are outlined. Environmental and activity effects on EVA equipment are assessed, and emphasis is placed on planetary surface portable life support systems (PLSS), suit development, protection from micrometeoroids, dust, and radiation, food and water supplies, and the extravehicular mobility-unit thermal-control system. Environmental and activity impacts on PLSS design are studied, with focus on base self-sufficiency and reduction in resupply logistics.

  13. Engaging the Families of ELLs: Ideas, Resources, and Activities

    ERIC Educational Resources Information Center

    Rubin, Renee; Abrego, Michelle H.; Sutterby, John A.

    2012-01-01

    Learn how to involve the diverse families of English language learners with the effective, practical approaches in this book. This must-have resource for teachers and school leaders is packed with fresh ideas geared toward building a partnership between school communities and ELL families. The authors begin each chapter with realistic scenarios…

  14. Global Issues: Activities and Resources for the High School Teacher.

    ERIC Educational Resources Information Center

    Switzer, Kenneth A.; Mulloy, Paul T.

    The book is an introduction to teaching about contemporary global concerns in the high school social studies classroom. It contains background and lesson plans for seven units in addition to 39 reproducible student handouts, annotated lists of other good classroom resources, and a guide to sources of teaching materials on global issues. Topics…

  15. Calcineurin activity is required for cardiac remodelling in pregnancy

    PubMed Central

    Chung, Eunhee; Yeung, Fan; Leinwand, Leslie A.

    2013-01-01

    Aims Calcium fluctuations and cardiac hypertrophy occur during pregnancy, but the role of the well-studied calcium-activated phosphatase, calcineurin, has not been studied in this setting. The purpose of this study was to determine whether calcineurin signalling is required for cardiac remodelling during pregnancy in mice. Methods and results We first examined calcineurin expression in the heart of mice during pregnancy. We found both calcineurin levels and activity were significantly increased in early-pregnancy and decreased in late-pregnancy. Since progesterone levels start to rise in early-pregnancy, we investigated whether progesterone alone was sufficient to modulate calcineurin levels in vivo. After implantation of progesterone pellets in non-pregnant female mice, cardiac mass increased, whereas cardiac function was maintained. In addition, calcineurin levels increased, which is also consistent with early-pregnancy. To determine whether these effects were occurring in the cardiac myocytes, we treated neonatal rat ventricular myocytes (NRVMs) with pregnancy-associated sex hormones. We found that progesterone treatment, but not oestradiol, increased calcineurin levels. To obtain a functional read-out of increased calcineurin activity, we measured the activity of the transcription factor NFAT, a downstream target of calcineurin. Progesterone treatment significantly increased NFAT activity in NRVMs, and this was blocked by the calcineurin inhibitor cyclosporine A (CsA), showing that the progesterone-mediated increase in NFAT activity requires calcineurin activity. Importantly, CsA treatment of mice completely blocked pregnancy-induced cardiac hypertrophy. Conclusion Our results show that calcineurin is required for pregnancy-induced cardiac hypertrophy, and that calcineurin activity in early-pregnancy is due at least in part to increased progesterone. PMID:23985902

  16. 48 CFR 801.602-73 - Review requirements for scarce medical specialist contracts and contracts for health-care resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... scarce medical specialist contracts and contracts for health-care resources. 801.602-73 Section 801.602... VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 801.602-73 Review requirements for scarce medical specialist contracts and contracts for...

  17. 48 CFR 801.602-73 - Review requirements for scarce medical specialist contracts and contracts for health-care resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... scarce medical specialist contracts and contracts for health-care resources. 801.602-73 Section 801.602... VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 801.602-73 Review requirements for scarce medical specialist contracts and contracts for...

  18. 48 CFR 801.602-73 - Review requirements for scarce medical specialist contracts and contracts for health-care resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... scarce medical specialist contracts and contracts for health-care resources. 801.602-73 Section 801.602... VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 801.602-73 Review requirements for scarce medical specialist contracts and contracts for...

  19. 48 CFR 801.602-73 - Review requirements for scarce medical specialist contracts and contracts for health-care resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... scarce medical specialist contracts and contracts for health-care resources. 801.602-73 Section 801.602... VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 801.602-73 Review requirements for scarce medical specialist contracts and contracts for...

  20. 48 CFR 801.602-73 - Review requirements for scarce medical specialist contracts and contracts for health-care resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... scarce medical specialist contracts and contracts for health-care resources. 801.602-73 Section 801.602... VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and Responsibilities 801.602-73 Review requirements for scarce medical specialist contracts and contracts for...

  1. 42 CFR 435.222 - Individuals under age 21 who meet the income and resource requirements of AFDC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... program but who meet the income and resource requirements of the State's approved AFDC plan. (b) The... foster homes or private institutions for whom a public agency is assuming a full or partial financial... nursing facility services are provided under the plan to individuals within the age group selected...

  2. 42 CFR 436.222 - Individuals under age 21 who meet the income and resource requirements of AFDC.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... assistance but who meet the income and resource requirements of the State's approved AFDC plan. (b) The... foster homes or private institutions for whom a public agency is assuming a full or partial financial... nursing facility services are provided under the plan to individuals within the age group selected...

  3. 33 CFR Appendix B to Part 155 - Determining and Evaluating Required Response Resources for Vessel Response Plans

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... or operator must refer to the applicable Area Contingency Plan to determine if ice, debris, and... exceeds the applicable cap described in Table 6 of this appendix, then a vessel owner or operator must contract for at least the quantity of resources required to meet the cap, but must identify sources...

  4. 33 CFR Appendix B to Part 155 - Determining and Evaluating Required Response Resources for Vessel Response Plans

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... or operator must refer to the applicable Area Contingency Plan to determine if ice, debris, and... exceeds the applicable cap described in Table 6 of this appendix, then a vessel owner or operator must contract for at least the quantity of resources required to meet the cap, but must identify sources...

  5. 33 CFR Appendix B to Part 155 - Determining and Evaluating Required Response Resources for Vessel Response Plans

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... or operator must refer to the applicable Area Contingency Plan to determine if ice, debris, and... exceeds the applicable cap described in Table 6 of this appendix, then a vessel owner or operator must contract for at least the quantity of resources required to meet the cap, but must identify sources...

  6. Adequacy of Material Resources Required for Effective Implementation of Upper Basic Education Business Studies Curriculum in Nigeria

    ERIC Educational Resources Information Center

    Okoli, B. E.; Okorie, Ogbonnaya

    2015-01-01

    This work is a descriptive survey of the adequacy of the material resources required for effective implementation of upper basic education business studies curriculum in Ebonyi State. Two research questions and two hypotheses guided the study. The entire population of two hundred and forty-one (241) business studies teachers were used for the…

  7. ORACLE (Oversight of Resources and Capability for Logistics Effectiveness) and Requirements Forecasting. Volume 3. Predicting the Peacetime Spares Requirements.

    DTIC Science & Technology

    1988-05-01

    computation model given in App. B, each of the above quantities can be evaluated fo, each item, which permits computation of the cumulative buy requirements...level of funding in the early ypars , which then drops sharply. To facilitate predicting this age-induced cost, we have included the quantity l/(l+avage

  8. Associations between Neighborhood Resources and Physical Activity in Inner City Minority Children

    PubMed Central

    Galvez, Maida P.; McGovern, Kathleen; Knuff, Catherine; Resnick, Susan; Brenner, Barbara; Teitelbaum, Susan L.; Wolff, Mary S.

    2013-01-01

    Objective The role of neighborhood physical activity resources on childhood physical activity level is increasingly examined in pediatric obesity research. We describe how availability of physical activity resources varies by individual and block characteristics and then examine its associations with physical activity levels of Latino and black children in East Harlem, New York City. Methods Physical activity resource availability by individual and block characteristics were assessed in 324 children. Availability was measured against four physical activity measures: average weekly hours of outdoor unscheduled physical activity, average weekly metabolic hours of scheduled physical activity, daily hours of sedentary behavior and daily steps. Results Physical activity resource availability differed by race/ethnicity, caregiver education and income. Presence of one or more playgrounds on a child’s block was positively associated with outdoor unscheduled physical activity (OR=1.95, 95% confidence interval 1.11–3.43). Presence of an afterschool program on a child’s block was associated with increased hours of scheduled physical activity (OR=3.25, 95% confidence interval 1.41–7.50) and decreased sedentary behavior (OR=3.24, 95% confidence interval 1.30–8.07). The more resources a child had available, the greater the level of outdoor unscheduled physical activity (p for linear trend=.026). Conclusions Neighborhood physical activity resource availability differs by demographic factors, potentially placing certain groups at risk for low physical activity level. Availability of select physical activity resources was associated with reported physical activity levels of East Harlem children but not with objective measures of physical activity. PMID:23312856

  9. Time required for motor activity in lucid dreams.

    PubMed

    Erlacher, Daniel; Schredl, Michael

    2004-12-01

    The present study investigated the relationship between the time required for specific tasks (counting and performing squats) in lucid dreams and in the waking state. Five proficient lucid dreamers (26-34 yr. old, M=29.8, SD=3.0; one woman and four men) participated. Analysis showed that the time needed for counting in a lucid dream is comparable to the time needed for counting in wakefulness, but motor activities required more time in lucid dreams than in the waking state.

  10. Planetary science and resource utilization at a lunar outpost - Chemical analytical facility requirements

    NASA Technical Reports Server (NTRS)

    Taylor, Lawrence A.

    1992-01-01

    Unresolved issues of lunar geology are reviewed and the role of a lunar outpost in helping to address them is considered. Plans for in situ resource utilization of lunar materials are examined. Concepts for a lunar outpost are described.

  11. Preconstruction schedules, costs, and permit requirements for electric power generating resources in the Pacific Northwest

    SciTech Connect

    Hendrickson, P.L.; Smith, S.A.; Thurman, A.G.; Watts, R.L.; Weakley, S.A.

    1990-07-01

    This report was prepared for the Generation Programs Branch, Office of Energy Resources, Bonneville Power Administration (BPA). The principal objective of the report is to assemble in one document preconstruction cost, schedule, and permit information for twelve specific generating resources. The report is one of many documents that provide background information for BPA's Resource Program, which is designed to identify the type and amount of new resources that BPA may have to add over the next twenty years to maintain an adequate and reliable electric power supply in the Pacific Northwest. A predecessor to this report is a 1982 report prepared by the Pacific Northwest Laboratory (PNL) for the Northwest Power Planning Council (the Council''). The 1982 report had a similar, but not identical, content and format. 306 refs., 14 figs., 22 tabs.

  12. Image data processing system requirements study. Volume 1: Analysis. [for Earth Resources Survey Program

    NASA Technical Reports Server (NTRS)

    Honikman, T.; Mcmahon, E.; Miller, E.; Pietrzak, L.; Yorsz, W.

    1973-01-01

    Digital image processing, image recorders, high-density digital data recorders, and data system element processing for use in an Earth Resources Survey image data processing system are studied. Loading to various ERS systems is also estimated by simulation.

  13. 48 CFR 873.109 - General requirements for acquisition of health-care resources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... market research, including the determination that the acquisition involves health-care resources; (3) The... time during the acquisition process if cancellation is determined to be in the best interest of...

  14. Invaders do not require high resource levels to maintain physiological advantages in a temperate deciduous forest.

    PubMed

    Heberling, J Mason; Fridley, Jason D

    2016-04-01

    Non-native, invasive plants are commonly typified by trait strategies associated with high resource demands and plant invasions are often thought to be dependent upon site resource availability or disturbance. However, the invasion of shade-tolerant woody species into deciduous forests of the Eastern United States seems to contradict such generalization, as growth in this ecosystem is strongly constrained by light and, secondarily, nutrient stress. In a factorial manipulation of light and soil nitrogen availability, we established an experimental resource gradient in a secondary deciduous forest to test whether three common, woody, invasive species displayed increased metabolic performance and biomass production compared to six co-occurring woody native species, and whether these predicted differences depend upon resource supply. Using hierarchical Bayesian models of photosynthesis that included leaf trait effects, we found that invasive species exhibited functional strategies associated with higher rates of carbon gain. Further, invader metabolic and growth-related attributes were more responsive to increasing light availability than those of natives, but did not fall below average native responses even in low light. Surprisingly, neither group showed direct trait or growth responses to soil N additions. However, invasive species showed increased photosynthetic nitrogen use efficiencies with decreasing N availability, while that of natives remained constant. Although invader advantage over natives was amplified in higher resource conditions in this forest, our results indicate that some invasive species can maintain physiological advantages over co-occurring natives regardless of resource conditions.

  15. Validating Vegetable Production Unit (VPU) Plants, Protocols, Procedures and Requirements (P3R) using Currently Existing Flight Resources

    NASA Technical Reports Server (NTRS)

    Bingham, Gail; Bates, Scott; Bugbee, Bruce; Garland, Jay; Podolski, Igor; Levinskikh, Rita; Sychev, Vladimir; Gushin, Vadim

    2009-01-01

    Validating Vegetable Production Unit (VPU) Plants, Protocols, Procedures and Requirements (P3R) Using Currently Existing Flight Resources (Lada-VPU-P3R) is a study to advance the technology required for plant growth in microgravity and to research related food safety issues. Lada-VPU-P3R also investigates the non-nutritional value to the flight crew of developing plants on-orbit. The Lada-VPU-P3R uses the Lada hardware on the ISS and falls under a cooperative agreement between National Aeronautics and Space Administration (NASA) and the Russian Federal Space Association (FSA). Research Summary: Validating Vegetable Production Unit (VPU) Plants, Protocols, Procedures and Requirements (P3R) Using Currently Existing Flight Resources (Lada-VPU-P3R) will optimize hardware and

  16. JOSHUA: Symmetric Active/Active Replication for Highly Available HPC Job and Resource Management

    SciTech Connect

    Uhlemann, Kai; Engelmann, Christian; Scott, Steven L

    2006-01-01

    Most of today's HPC systems employ a single head node for control, which represents a single point of failure as it interrupts an entire HPC system upon failure. Furthermore, it is also a single point of control as it disables an entire HPC system until repair. One of the most important HPC system service running on the head node is the job and resource management. If it goes down, all currently running jobs loose the service they report back to. They have to be restarted once the head node is up and running again. With this paper, we present a generic approach for providing symmetric active/active replication for highly available HPC job and resource management. The JOSHUA solution provides a virtually synchronous environment for continuous availability without any interruption of service and without any loss of state. Replication is performed externally via the PBS service interface without the need to modify any service code. Test results as well as a reliability analysis of our proof-of-concept prototype implementation show that continuous availability can be provided by JOSHUA with an acceptable performance trade-off.

  17. Impact of regular physical activity on weekly warfarin dose requirement.

    PubMed

    Rouleau-Mailloux, Étienne; Shahabi, Payman; Dumas, Stéphanie; Feroz Zada, Yassamin; Provost, Sylvie; Hu, Jason; Nguyen, Jacqueline; Bouchama, Nawal; Mongrain, Ian; Talajic, Mario; Tardif, Jean-Claude; Perreault, Sylvie; Dubé, Marie-Pierre

    2016-02-01

    Warfarin is an oral anticoagulant agent with a narrow therapeutic index. There is a marked inter- and intra-patient variability in warfarin dose requirement. All factors influencing warfarin response are not known and this study aims to evaluate if regular physical activity (RPA) is a determining factor. RPA level was collected with the Stanford Brief Activity Survey in 1064 incident warfarin users, as part of the Quebec Warfarin Cohort (QWC), and with the Global Physical Activity Questionnaire in 618 patients from the Montreal Heart Institute (MHI) Biobank. Linear regression was performed to model relationship of warfarin dose after 3 months of therapy in the QWC with RPA, while controlling for height, weight, age, CYP2C9 (*2 and *3 alleles) and VKORC1 (*2 allele) genotype. Warfarin dose of prevalent users was modeled in the MHI Biobank for replication. A higher level of physical activity was associated with higher doses of warfarin in both cohorts. In the QWC, physical activity could explain 5.4 % (P < 0.001) and 0.9 % (P = 3.23 × 10(-5)) of variance in dose, in univariate and multivariable models, respectively. Similarly, RPA was found to be associated with 1.7 % (P = 0.0012) and 0.5 % (P = 0.0391) of inter-individual variability in warfarin dose requirement before and after adjustment for other covariables, respectively. RPA is associated with higher warfarin dose requirement. The relevance of clinical recommendations on RPA to maintain a steady response to warfarin should be assessed in further studies.

  18. Give me a better break: Choosing workday break activities to maximize resource recovery.

    PubMed

    Hunter, Emily M; Wu, Cindy

    2016-02-01

    Surprisingly little research investigates employee breaks at work, and even less research provides prescriptive suggestions for better workday breaks in terms of when, where, and how break activities are most beneficial. Based on the effort-recovery model and using experience sampling methodology, we examined the characteristics of employee workday breaks with 95 employees across 5 workdays. In addition, we examined resources as a mediator between break characteristics and well-being. Multilevel analysis results indicated that activities that were preferred and earlier in the work shift related to more resource recovery following the break. We also found that resources mediated the influence of preferred break activities and time of break on health symptoms and that resource recovery benefited person-level outcomes of emotional exhaustion, job satisfaction, and organizational citizenship behavior. Finally, break length interacted with the number of breaks per day such that longer breaks and frequent short breaks were associated with more resources than infrequent short breaks.

  19. Autophagy is required for the activation of NFκB.

    PubMed

    Criollo, Alfredo; Chereau, Fanny; Malik, Shoaib Ahmad; Niso-Santano, Mireia; Mariño, Guillermo; Galluzzi, Lorenzo; Maiuri, Maria Chiara; Baud, Véronique; Kroemer, Guido

    2012-01-01

    It is well-established that the activation of the inhibitor of NFκB (IκBα) kinase (IKK) complex is required for autophagy induction by multiple stimuli. Here, we show that in autophagy-competent mouse embryonic fibroblasts (MEFs), distinct autophagic triggers, including starvation, mTOR inhibition with rapamycin and p53 inhibition with cyclic pifithrin α lead to the activation of IKK, followed by the phosphorylation-dependent degradation of IκBα and nuclear translocation of NFκB. Remarkably, the NFκB signaling pathway was blocked in MEFs lacking either the essential autophagy genes Atg5 or Atg7. In addition, we found that tumor necrosis factor α (TNFα)-induced NFκB nuclear translocation is abolished in both Atg5- and Atg7-deficient MEFs. Similarly, the depletion of essential autophagy modulators, including ATG5, ATG7, Beclin 1 and VPS34, by RNA interference inhibited TNFα-driven NFκB activation in two human cancer cell lines. In conclusion, it appears that, at least in some instances, autophagy is required for NFκB activation, highlighting an intimate crosstalk between these two stress response signaling pathways.

  20. Phosphorylation at serine 331 is required for Aurora B activation

    PubMed Central

    Petsalaki, Eleni; Akoumianaki, Tonia; Black, Elizabeth J.; Gillespie, David A.F.

    2011-01-01

    Aurora B kinase activity is required for successful cell division. In this paper, we show that Aurora B is phosphorylated at serine 331 (Ser331) during mitosis and that phosphorylated Aurora B localizes to kinetochores in prometaphase cells. Chk1 kinase is essential for Ser331 phosphorylation during unperturbed prometaphase or during spindle disruption by taxol but not nocodazole. Phosphorylation at Ser331 is required for optimal phosphorylation of INCENP at TSS residues, for Survivin association with the chromosomal passenger complex, and for complete Aurora B activation, but it is dispensable for Aurora B localization to centromeres, for autophosphorylation at threonine 232, and for association with INCENP. Overexpression of Aurora BS331A, in which Ser331 is mutated to alanine, results in spontaneous chromosome missegregation, cell multinucleation, unstable binding of BubR1 to kinetochores, and impaired mitotic delay in the presence of taxol. We propose that Chk1 phosphorylates Aurora B at Ser331 to fully induce Aurora B kinase activity. These results indicate that phosphorylation at Ser331 is an essential mechanism for Aurora B activation. PMID:22024163

  1. Army Corps of Engineers: Water Resource Authorizations, Appropriations, and Activities

    DTIC Science & Technology

    2013-10-18

    ecosystems. Congress directs the Corps through authorizations, appropriations, and oversight of its studies , construction projects, and other activities...appropriations, many authorized activities have not received appropriations. There is a backlog of more than 1,000 authorized studies and construction...projects. In recent years, few new studies and new construction activities have been in either the President’s budget request or enacted appropriations

  2. 78 FR 23233 - Agency Information Collection Activities; Comment Request; IEPS International Resource...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... Agency Information Collection Activities; Comment Request; IEPS International Resource Information System... Information System (IRIS). OMB Control Number: 1840-0759. Type of Review: a revision of an existing... the on-line reporting system, International Resource Information System (IRIS) that IFLE uses...

  3. 78 FR 18562 - Economic and Environmental Principles and Requirements for Water and Related Land Resources...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ... Guidelines consist of three key components: (1) The Principles and Requirements (formerly called Principles... agency missions and programs. This notice is to inform you that the Principles and Requirements, one key... QUALITY Economic and Environmental Principles and Requirements for Water and Related Land...

  4. Water-resources activities in New York, 1987-88

    USGS Publications Warehouse

    Marshall, Mary P.; Finch, Anne J.

    1988-01-01

    The U.S. Geological Survey conducted more than 35 water resources projects in New York in 1987-88. These studies, done largely through cooperative joint-funding programs with the state, County, and local agencies, encompass statewide networks of measurement stations that provide continuous records of streamflow, groundwater levels, and water quality; they also address regional and local problems as well as critical problems of national scope. Some of the questions addressed by these studies are the effect of sewers on groundwater levels and streamflow on Long Island; the occurrence and transport of PCB residues within the upper Hudson River basin; the effect of acid rain on streams in the Catskill Mountains; the frequency and magnitude of floods statewide; the role of wetlands in improving the chemical quality of landfill leachate; the direction of groundwater movement from waste disposal sites near the Niagara River; and the location and potential well yields of stratified-drift aquifers in upstate New York. (USGS)

  5. Physician resource databank: numbers, distribution and activities of Canada's physicians

    PubMed Central

    Woodward, Christel; Adams, Orvill

    1985-01-01

    The physician resource databank, compiled and maintained by the Canadian Medical Association (CMA), contains functional information from 41 599 of Canada's licensed physicians. The information was gathered from a 20-item questionnaire sent to 47 162 physicians. Of the total, 38 653 responses came from physicians who had completed their training and these were included in the analysis to produce a profile of the supply of physicians in Canada. The data from physicians younger than 35 years indicate some changes in the structure of the supply: 27% are women (compared with only about 9% of physicians older than 45 years). The implications of these statistics are not yet clear, but within the next decade the numbers in some specialties—surgery, anesthesia, obstetrics and gynecology, and radiology—may be too few to meet the demand as more than 20% of the current practitioners reach retirement age. Other findings are that [List: see text] PMID:3995440

  6. Activated carbon fibers and engineered forms from renewable resources

    DOEpatents

    Baker, Frederick S.

    2010-06-01

    A method of producing activated carbon fibers (ACFs) includes the steps of providing a natural carbonaceous precursor fiber material, blending the carbonaceous precursor material with a chemical activation agent to form chemical agent-impregnated precursor fibers, spinning the chemical agent-impregnated precursor material into fibers, and thermally treating the chemical agent-impregnated precursor fibers. The carbonaceous precursor material is both carbonized and activated to form ACFs in a single step. The method produces ACFs exclusive of a step to isolate an intermediate carbon fiber.

  7. Activated carbon fibers and engineered forms from renewable resources

    DOEpatents

    Baker, Frederick S

    2013-02-19

    A method of producing activated carbon fibers (ACFs) includes the steps of providing a natural carbonaceous precursor fiber material, blending the carbonaceous precursor material with a chemical activation agent to form chemical agent-impregnated precursor fibers, spinning the chemical agent-impregnated precursor material into fibers, and thermally treating the chemical agent-impregnated precursor fibers. The carbonaceous precursor material is both carbonized and activated to form ACFs in a single step. The method produces ACFs exclusive of a step to isolate an intermediate carbon fiber.

  8. Liver-specific activities of FGF19 require Klotho beta.

    PubMed

    Lin, Benjamin C; Wang, Manping; Blackmore, Craig; Desnoyers, Luc R

    2007-09-14

    Hepatocyte function is regulated by members of the fibroblast growth factor (FGF) family of proteins, but little is known about the specific molecular mechanisms of this endocrine pathway. FGF19 regulates bile acid homeostasis and gall bladder filling; FGF19 binds only to FGF receptor 4 (FGFR4), but its liver-specific activity cannot be explained solely by the distribution of this receptor. Although it has been suggested that Klotho beta (KLB) may have a role in mediating FGF19 activity, we have provided for the first time definitive evidence that KLB is required for FGF19 binding to FGFR4, intracellular signaling, and downstream modulation of gene expression. We have shown that FGFR4 is widely distributed in mouse, whereas KLB distribution is more restricted. Liver was the only organ in which both genes were abundantly expressed. We show that in mice, FGF19 injection triggers liver-specific induction of c-Fos and repression of CYP7A1. The tissue-specific activity of FGF19 supports the unique intersection of KLB and FGFR4 distribution in liver. These studies define KLB as a novel FGFR4 coreceptor required for FGF19 liver specific functions.

  9. Phospholipase C activation is required for cardioprotection by ethanol consumption

    PubMed Central

    Miyamae, Masami; Domae, Naochika; Zhou, Hui-Zhong; Sugioka, Shingo; Diamond, Ivan; Figueredo, Vincent M

    2003-01-01

    Regular alcohol consumption decreases the incidence of myocardial infarction (MI) and improves post-MI survival. It has previously been reported that chronic ethanol exposure induces long-term protection against cardiac ischemia/reperfusion injury, which improves myocardial recovery after MI. Chronic cardioprotection by ethanol requires the activation of myocyte adenosine A1 receptors and sustained intramyocyte translocation of epsilon protein kinase C. A1 receptors activate phospholipase C (PLC). In the present paper, the role of PLC in mediating ethanol’s protective effect against ischemia/reperfusion injury is investigated. Isolated hearts from guinea pigs fed 2.5% ethanol in their water for four months were subjected to ischemia/reperfusion. Hearts from ethanol-treated animals showed improved recovery of left ventricular developed pressure compared with controls (61% versus 38% of baseline, respectively; P<0.05) and decreased necrosis, assessed by the release of creatine kinase (263±18 U/mL × g dry weight versus 360±24 U/mL × g dry weight, respectively; P<0.05). Ethanol protection was abolished by the PLC antagonist, U-73122 (50 nM). These findings suggest that PLC activation is required for ethanol cardioprotection against ischemia/reperfusion injury. PMID:19649218

  10. EPA Releases Draft Assessment on the Potential Impacts to Drinking Water Resources from Hydraulic Fracturing Activities

    EPA Pesticide Factsheets

    WASHINGTON-The Environmental Protection Agency (EPA) is releasing a draft assessment today on the potential impacts of hydraulic fracturing activities on drinking water resources in the United States. The assessment, done at the request of Congress, shows

  11. Molecular Requirements for the Biological Activity of Ethylene 1

    PubMed Central

    Burg, Stanley P.; Burg, Ellen A.

    1967-01-01

    The molecular requirements for ethylene action were investigated using the pea straight growth test. Biological activity requires an unsaturated bond adjacent to a terminal carbon atom, is inversely related to molecular size, and is decreased by substitutions which lower the electron density in the unsaturated position. Evidence is presented that ethylene binds to a metal containing receptor site. CO2 is a competitive inhibitor of ethylene action, and prevents high concentrations of auxin (which stimulate ethylene formation) from retarding the elongation of etiolated pea stem sections. It is suggested that CO2 delays fruit ripening by displacing the ripening hormone, ethylene, from its receptor site. Binding of ethylene to the receptor site is also impeded when the O2 concentration is lowered, and this may explain why fruit ripening is delayed at low O2 tensions. PMID:16656478

  12. Army Corps of Engineers: Water Resource Authorizations, Appropriations, and Activities

    DTIC Science & Technology

    2014-07-01

    aquatic ecosystems. Congress directs the Corps through authorizations, appropriations, and oversight of its studies , construction projects, and other...appropriations, many authorized activities have not received appropriations. There is a backlog of more than 1,000 authorized studies and construction...projects. In recent years, few new studies and new construction activities have been in either the President’s budget request or enacted appropriations

  13. Agrp neuron activity is required for alcohol-induced overeating

    PubMed Central

    Cains, Sarah; Blomeley, Craig; Kollo, Mihaly; Rácz, Romeo; Burdakov, Denis

    2017-01-01

    Alcohol intake associates with overeating in humans. This overeating is a clinical concern, but its causes are puzzling, because alcohol (ethanol) is a calorie-dense nutrient, and calorie intake usually suppresses brain appetite signals. The biological factors necessary for ethanol-induced overeating remain unclear, and societal causes have been proposed. Here we show that core elements of the brain's feeding circuits—the hypothalamic Agrp neurons that are normally activated by starvation and evoke intense hunger—display electrical and biochemical hyperactivity on exposure to dietary doses of ethanol in brain slices. Furthermore, by circuit-specific chemogenetic interference in vivo, we find that the Agrp cell activity is essential for ethanol-induced overeating in the absence of societal factors, in single-housed mice. These data reveal how a widely consumed nutrient can paradoxically sustain brain starvation signals, and identify a biological factor required for appetite evoked by alcohol. PMID:28072397

  14. Natural resources management activities and biodiversity maintenance. Progress report, July 1, 1994--June 30, 1995

    SciTech Connect

    Caudell, M.B.

    1995-05-01

    This progress report for the Natural Resources Management Activities and Biodiversity Maintenance for the time period July 1, 1994 - June 30, 1995 was submitted to the DOE by the South Carolina Department of Natural Resources. The activities devoted to revitilization of wildlife areas and reintroduction of various animal species to wildlife areas (such as Crackerneck Wildlife Management Area) are described. Other information regarding site characterization, land use and resource management in South Carolina is provided. Also, a description of attendence to various meetings and certification seminars is covered.

  15. Advanced extravehicular activity systems requirements definition study. Phase 2: Extravehicular activity at a lunar base

    NASA Technical Reports Server (NTRS)

    Neal, Valerie; Shields, Nicholas, Jr.; Carr, Gerald P.; Pogue, William; Schmitt, Harrison H.; Schulze, Arthur E.

    1988-01-01

    The focus is on Extravehicular Activity (EVA) systems requirements definition for an advanced space mission: remote-from-main base EVA on the Moon. The lunar environment, biomedical considerations, appropriate hardware design criteria, hardware and interface requirements, and key technical issues for advanced lunar EVA were examined. Six remote EVA scenarios (three nominal operations and three contingency situations) were developed in considerable detail.

  16. An investigation into the resource requirements of event-based prospective memory.

    PubMed

    Loft, Shayne; Yeo, Gillian

    2007-03-01

    The multiprocess view proposes that both strategic and automatic processes can support prospective memory. In three experiments, we embedded a prospective memory task in a lexical decision task; cues were either highly associated with response words or had no relation. Analyses of RTs on ongoing task trials indicated that (1) prospective memory was more dependent on the allocation of resources immediately prior to cue presentation under conditions of low association in comparison with high association and (2) processes engaged on cue trials were more resource demanding under conditions of low association in comparison with high association. These data support the claim of the multiprocess view that prospective memory can be more resource demanding under some task conditions in comparison with others. However, the prospective memory performance data were less supportive, with declines in prospective memory due to task-importance and cue-frequency manipulations comparable across the low- and high-association conditions. Taken together, these results have implications for two prominent theories of prospective memory.

  17. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the IT Security Web site at https://itsecurity.nasa.gov/policies/index.html. (d) The contractor shall... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Security requirements for... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.204-76 Security requirements for...

  18. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the IT Security Web site at https://itsecurity.nasa.gov/policies/index.html. (d) The contractor shall... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Security requirements for... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.204-76 Security requirements for...

  19. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the IT Security Web site at https://itsecurity.nasa.gov/policies/index.html. (d) The contractor shall... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Security requirements for... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.204-76 Security requirements for...

  20. 48 CFR 1852.204-76 - Security requirements for unclassified information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the IT Security Web site at https://itsecurity.nasa.gov/policies/index.html. (d) The contractor shall... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Security requirements for... CONTRACT CLAUSES Texts of Provisions and Clauses 1852.204-76 Security requirements for...

  1. Active prospective control is required for effective sensorimotor learning.

    PubMed

    Snapp-Childs, Winona; Casserly, Elizabeth; Mon-Williams, Mark; Bingham, Geoffrey P

    2013-01-01

    Passive modeling of movements is often used in movement therapy to overcome disabilities caused by stroke or other disorders (e.g. Developmental Coordination Disorder or Cerebral Palsy). Either a therapist or, recently, a specially designed robot moves or guides the limb passively through the movement to be trained. In contrast, action theory has long suggested that effective skill acquisition requires movements to be actively generated. Is this true? In view of the former, we explicitly tested the latter. Previously, a method was developed that allows children with Developmental Coordination Disorder to produce effective movements actively, so as to improve manual performance to match that of typically developing children. In the current study, we tested practice using such active movements as compared to practice using passive movement. The passive movement employed, namely haptic tracking, provided a strong test of the comparison, one that showed that the mere inaction of the muscles is not the problem. Instead, lack of prospective control was. The result was no effective learning with passive movement while active practice with prospective control yielded significant improvements in performance.

  2. Resource of Creative and Inventive Activities! First Edition.

    ERIC Educational Resources Information Center

    Rowland, Elizabeth, Comp.; Molotsky, Leonard, Comp.

    This guide encourages a learning environment that allows for creativity. Creative theory, assessment, and talent identification information is given. Student activities are presented to encourage creative problem solving, dispel myths and misunderstandings about creativity, provide exercises in brainstorming, creative thinking, and making cross…

  3. Doing the Media: A Portfolio of Activities and Resources.

    ERIC Educational Resources Information Center

    Laybourne, Kit, Ed.

    Because of the prevalence of media in all people's lives and the cultural and perceptual changes brought about by the media, education must create ways to enable children to master the media's codes and control its impact so that they will be active, intelligent, appreciative, and selective consumers of the total media culture. This portfolio…

  4. Houses and Their Resource-Rich Activity Pockets.

    ERIC Educational Resources Information Center

    Moore, Gary T.

    1997-01-01

    Provides a list of developmentally appropriate activity areas for infants, toddlers, and preschoolers which could be used in multi-house, module, or medium-sized child care centers. Describes these age-appropriate physical, academic, sensory-motor, fine arts, and multi-use areas, and provides suggestions for inexpensive materials, toys, storage,…

  5. User requirements and user acceptance of current and next-generation satellite mission and sensor complement, oriented toward the monitoring of water resources

    NASA Technical Reports Server (NTRS)

    Castruccio, P. A.; Loats, H. L., Jr.; Fowler, T. R.; Robinson, P.

    1975-01-01

    Principal water resources users were surveyed to determine the applicability of remotely sensed data to their present and future requirements. Analysis of responses was used to assess the levels of adequacy of LANDSAT 1 and 2 in fulfilling hydrological functions, and to derive systems specifications for future water resources-oriented remote sensing satellite systems. The analysis indicates that water resources applications for all but the very large users require: (1) resolutions on the order of 15 meters, (2) a number of radiometric levels of the same order as currently used in LANDSAT 1 (64), (3) a number of spectral bands not in excess of those used in LANDSAT 1, and (4) a repetition frequency on the order of 2 weeks. The users had little feel for the value of new sensors (thermal IR, passive and active microwaves). What is needed in this area is to achieve specific demonstrations of the utility of these sensors and submit the results to the users to evince their judgement.

  6. The Impact of Library Resources and Services on the Scholarly Activity of Medical Faculty and Residents.

    PubMed

    Quesenberry, Alexandria C; Oelschlegel, Sandy; Earl, Martha; Leonard, Kelsey; Vaughn, Cynthia J

    2016-01-01

    Librarians at an academic medical center library gathered data to determine if library services and resources impacted scholarly activity. A survey was developed and sent out to faculty and residents asking how they used the library during scholarly activity. Sixty-five faculty members and residents responded to the survey. The majority of respondents involved with scholarly activity use the library's services and resources. PubMed is the most frequently used database. The positive results show the library impacts the scholarly activity of medical faculty and residents.

  7. Schwann cell myelination requires integration of laminin activities.

    PubMed

    McKee, Karen K; Yang, Dong-Hua; Patel, Rajesh; Chen, Zu-Lin; Strickland, Sidney; Takagi, Junichi; Sekiguchi, Kiyotoshi; Yurchenco, Peter D

    2012-10-01

    Laminins promote early stages of peripheral nerve myelination by assembling basement membranes (BMs) on Schwann cell surfaces, leading to activation of β1 integrins and other receptors. The BM composition, structural bonds and ligands needed to mediate this process, however, are not well understood. Mice hypomorphic for laminin γ1-subunit expression that assembled endoneurial BMs with reduced component density exhibited an axonal sorting defect with amyelination but normal Schwann cell proliferation, the latter unlike the null. To identify the basis for this, and to dissect participating laminin interactions, LAMC1 gene-inactivated dorsal root ganglia were treated with recombinant laminin-211 and -111 lacking different architecture-forming and receptor-binding activities, to induce myelination. Myelin-wrapping of axons by Schwann cells was found to require higher laminin concentrations than either proliferation or axonal ensheathment. Laminins that were unable to polymerize through deletions that removed critical N-terminal (LN) domains, or that lacked cell-adhesive globular (LG) domains, caused reduced BMs and almost no myelination. Laminins engineered to bind weakly to α6β1 and/or α7β1 integrins through their LG domains, even though they could effectively assemble BMs, decreased myelination. Proliferation depended upon both integrin binding to LG domains and polymerization. Collectively these findings reveal that laminins integrate scaffold-forming and cell-adhesion activities to assemble an endoneurial BM, with myelination and proliferation requiring additional α6β1/α7β1-laminin LG domain interactions, and that a high BM ligand/structural density is needed for efficient myelination.

  8. 17 CFR 39.33 - Financial resources requirements for systemically important derivatives clearing organizations...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... requirements for systemically important derivatives clearing organizations and subpart C derivatives clearing... DERIVATIVES CLEARING ORGANIZATIONS Provisions Applicable to Systemically Important Derivatives Clearing Organizations and Derivatives Clearing Organizations That Elect To Be Subject to the Provisions of This...

  9. 43 CFR 3900.62 - Special requirements to protect the lands and resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) OIL SHALE MANAGEMENT-GENERAL Oil Shale Management-Introduction § 3900.62 Special requirements to protect the lands...

  10. 43 CFR 3900.62 - Special requirements to protect the lands and resources.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE MANAGEMENT-GENERAL Oil Shale Management-Introduction § 3900.62 Special requirements to protect the lands...

  11. 43 CFR 3900.62 - Special requirements to protect the lands and resources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE MANAGEMENT-GENERAL Oil Shale Management-Introduction § 3900.62 Special requirements to protect the lands...

  12. 43 CFR 3900.62 - Special requirements to protect the lands and resources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE MANAGEMENT-GENERAL Oil Shale Management-Introduction § 3900.62 Special requirements to protect the lands...

  13. Offshore Resource Assessment and Design Conditions: A Data Requirements and Gaps Analysis for Offshore Renewable Energy Systems

    SciTech Connect

    Elliott, Dennis; Frame, Caitlin; Gill, Carrie; Hanson, Howard; Moriarty, Patrick; Powell, Mark; Shaw, William J.; Wilczak, Jim; Wynne, Jason

    2012-03-01

    The offshore renewable energy industry requires accurate meteorological and oceanographic (“metocean”) data for evaluating the energy potential, economic viability, and engineering requirements of offshore renewable energy projects. It is generally recognized that currently available metocean data, instrumentation, and models are not adequate to meet all of the stakeholder needs on a national scale. Conducting wind and wave resource assessments and establishing load design conditions requires both interagency collaboration as well as valuable input from experts in industry and academia. Under the Department of Energy and Department of Interior Memorandum of Understanding, the Resource Assessment and Design Condition initiative supports collaborative national efforts by adding to core atmospheric and marine science knowledge relevant to offshore energy development. Such efforts include a more thorough understanding and data collection of key metocean phenomena such as wind velocity and shear; low-level jets; ocean, tidal, and current velocities; wave characteristics; geotechnical data relating to surface and subsurface characteristics; seasonal and diurnal variations; and the interaction among these conditions. Figure 1 presents a graphical representation of some metocean phenomena that can impact offshore energy systems. This document outlines the metocean observations currently available; those that are not available; and those that require additional temporal-spatial coverage, resolution, or processing for offshore energy in an effort to gather agreed-upon, needed observations.

  14. Natural products as a resource for biologically active compounds

    SciTech Connect

    Hanke, F.J.

    1986-01-01

    The goal of this study was to investigate various sources of biologically active natural products in an effort to identify the active pesticidal compounds involved. The study is divided into several parts. Chapter 1 contains a discussion of several new compounds from plant and animal sources. Chapter 2 introduces a new NMR technique. In section 2.1 a new technique for better utilizing the lanthanide relaxation agent Gd(fod)/sub 3/ is presented which allows the predictable removal of resonances without line broadening. Section 2.2 discusses a variation of this technique for use in an aqueous solvent by applying this technique towards identifying the binding sites of metals of biological interest. Section 2.3 presents an unambiguous /sup 13/C NMR assignment of melibiose. Chapter 3 deals with work relating to the molting hormone of most arthropods, 20-hydroxyecdysone. Section 3.1 discusses the use of two-dimensional NMR (2D NMR) to assign the /sup 1/H NMR spectrum of this biologically important compound. Section 3.2 presents a new application for Droplet countercurrent chromatography (DCCC). Chapter 4 presents a basic improvement to the commercial DCCC instrument that is currently being applied to future commercial instruments. Chapter 5 discusses a curious observation of the effects that two previously known compounds, nagilactone C and (-)-epicatechin, have on lettuce and rice and suggest a possible new role for the ubiquitous flavanol (-)-epicatechin in plants.

  15. Annual report on the U.S. Department of Energy`s Cultural Resource Activities at Colorado UMTRA Project Sites for October 1993 through September 1994

    SciTech Connect

    Not Available

    1994-11-01

    This report summarizes the results of cultural resource activities conducted by the U.S. Department of Energy (DOE) at Uranium Mill Tailings Remedial Action (UMTRA) Project sites in Colorado for the period of October 1, 1993, through September 30, 1994. The UMTRA Project is a cooperative (state and federal) program mandated by the Uranium Mill Tailings Radiation Control Act, Public Law 95-604 (42 USC {section}7901 et seq.). This law requires the timely cleanup of 24 inactive uranium mill tailings sites throughout the United States. Nine of these inactive uranium mill tailings sites are in Colorado at Durango, Grand Junction, Gunnison, Maybell, Naturita, Rifle, and Slick Rock. On December 6, 1984, the DOE, Advisory Council on Historic Preservation, and Colorado State Historic Preservation Officer (SHPO) entered into a programmatic memorandum of agreement (PMOA) (DOE, 1984). This PMOA specifies requirements for the DOE`s fulfillment of its obligations under various state and federal regulations for the protection and preservation of cultural resources. This report fulfills the requirement for the DOE to provide the state of Colorado with an annual report on the cultural resource activities performed for all of the UMTRA Project sites in Colorado. This report is organized by UMTRA Project site. For each site, the general remedial action activities and cultural resource activities performed during the period of record are summarized. When known, the DOE`s plans for future cultural resource activities at the site are summarized.

  16. Access to environmental resources and physical activity levels of adults in Hawaii

    PubMed Central

    Geller, KS; Nigg, CR; Ollberding, NJ; Motl, RW; Horwath, C; Dishman, RK

    2012-01-01

    Purpose Examine associations between physical activity (PA) and spatial accessibility to environmental PA resources in Hawaii. Methods Metabolic equivalents (METs) of mild, moderate, and strenuous PA were compared for accessibility to environmental PA resources within a population-based sample of Hawaiian adults (n=381). Multiple linear regression estimated differences in PA levels for residing further from a PA resource or residing in an area with a greater number of resources. Results No associations were found in the total sample. Analyses within subsamples stratified by ethnicity revealed that greater spatial accessibility to a PA resource was positively associated with strenuous PA among Caucasians (p=0.04), but negatively associated with moderate PA among Native Hawaiians (p=0.00). Conclusion The lack of association in the total sample may be a consequence of Hawaii’s unique environment. Results of stratified sample analyses are unique, providing groundwork for future examinations within parallel environments and among similar ethnic groups. PMID:22500037

  17. EGI-EUDAT integration activity - Pair data and high-throughput computing resources together

    NASA Astrophysics Data System (ADS)

    Scardaci, Diego; Viljoen, Matthew; Vitlacil, Dejan; Fiameni, Giuseppe; Chen, Yin; sipos, Gergely; Ferrari, Tiziana

    2016-04-01

    EGI (www.egi.eu) is a publicly funded e-infrastructure put together to give scientists access to more than 530,000 logical CPUs, 200 PB of disk capacity and 300 PB of tape storage to drive research and innovation in Europe. The infrastructure provides both high throughput computing and cloud compute/storage capabilities. Resources are provided by about 350 resource centres which are distributed across 56 countries in Europe, the Asia-Pacific region, Canada and Latin America. EUDAT (www.eudat.eu) is a collaborative Pan-European infrastructure providing research data services, training and consultancy for researchers, research communities, research infrastructures and data centres. EUDAT's vision is to enable European researchers and practitioners from any research discipline to preserve, find, access, and process data in a trusted environment, as part of a Collaborative Data Infrastructure (CDI) conceived as a network of collaborating, cooperating centres, combining the richness of numerous community-specific data repositories with the permanence and persistence of some of Europe's largest scientific data centres. EGI and EUDAT, in the context of their flagship projects, EGI-Engage and EUDAT2020, started in March 2015 a collaboration to harmonise the two infrastructures, including technical interoperability, authentication, authorisation and identity management, policy and operations. The main objective of this work is to provide end-users with a seamless access to an integrated infrastructure offering both EGI and EUDAT services and, then, pairing data and high-throughput computing resources together. To define the roadmap of this collaboration, EGI and EUDAT selected a set of relevant user communities, already collaborating with both infrastructures, which could bring requirements and help to assign the right priorities to each of them. In this way, from the beginning, this activity has been really driven by the end users. The identified user communities are

  18. Requirements assessment and operational demands for a resource mapping rover mission to the lunar polar regions

    SciTech Connect

    KLARER,PAUL R.; BINDER,ALAN B.; LENARD,ROGER X.

    2000-01-26

    A preliminary set of requirements for a robotic rover mission to the lunar polar region are described and assessed. Tasks to be performed by the rover include core drill sample acquisition, mineral and volatile soil content assay, and significant wide area traversals. Assessment of the postulated requirements is performed using first order estimates of energy, power, and communications throughput issues. Two potential rover system configurations are considered, a smaller rover envisioned as part of a group of multiple rovers, and a larger single rover envisioned along more traditional planetary surface rover concept lines.

  19. Resource and energy management of synfuels production with hydrogen and oxygen requirements from electrolysis

    NASA Astrophysics Data System (ADS)

    Shannon, R. H.; Richardson, R. D.

    The Resource and Energy Management System (REM), which uses electrolytic H2 and O2 to produce synthetic crude and light oils from heavy hydrocarbons is described. The heavy hydrocarbon feedstocks include heavy oils, tar sand bitumens, heavy residual oils, oil shale kerogens, liquefied coal, and pyrolytically-extracted coal liquids. The system includes mini-upgraders, which can be implemented in modular form, to pump electrolytically-derived H2 into heavy oils to upgrade their energy content. Projected costs for the production of synthetic light oils using U.S. coal reserves with the REM process after liquefaction are $30-35/bbl, with the H2 costs being a controlling factor. The modular systems could be built in a much shorter time frame than much larger projects, and would be instrumental in establishing the electrolytic H2 production infrastructure needed for eventual full conversion to an H2-based economy.

  20. Curriculum Resources for Environmental Progress, Vol. 1: Curriculum Outline and Activities Guide.

    ERIC Educational Resources Information Center

    Kalamazoo Nature Center, Inc., MI.

    This publication is the first volume of curriculum resources published by the Kalamazoo Nature Center. It contains directions for using the curriculum activities guide and suggests ways of implementing the activities in the classroom. Also included is an outline of the material that could be covered in an environmental education program, with…

  1. Free To Choose: A Teacher's Resource and Activity Guide to Revolution and Reform in Eastern Europe.

    ERIC Educational Resources Information Center

    Chan, Adrian

    This teaching guide for grades 9-12 contains resource materials and activity suggestions that are designed to improve students' knowledge of post-war Eastern Europe and enable them to appreciate current events. The activities are appropriate for use in high school social studies classrooms, as well as for economics, world history, and U.S. history…

  2. Resource-based Learning Activities: Information Literacy for High School Students.

    ERIC Educational Resources Information Center

    Bleakley, Ann; Carrigan, Jackie L.

    This workbook is intended to help high school students achieve information literacy. It goes beyond basic library skills instruction to incorporate 50 different research activities into regular classroom curriculum. The activities provided for resource-based learning help the student to: (1) identify the kind of information needed; (2) locate and…

  3. Solid Waste Educational Resources and Activities: Let's Reduce, Reuse, and Recycle. [CD-ROM].

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC. Solid Waste and Emergency Response.

    This contains games, activities, publications, and resources for students and teachers on how to reduce, reuse, recycle, and properly manage waste. It also contains a screen saver featuring runners-up from the Earth Day 2000 art contest. Activities and games include titles such as "Planet Protectors,""Recycle City,""Trash…

  4. Waterworks Book. An Activity Book about Mississippi's Coastal Resources for Primary Grades.

    ERIC Educational Resources Information Center

    Howe, Kevin M.

    Coastal resources are highlighted in this activity book for primary school children. Special focus is given to Mississippi's coastal areas, but applications to other geographic areas can be made. Wetland concepts and conditions are developed through a variety of games, puzzles, matching exercises and pictorial explanations. Activities addressing…

  5. Idaho National Laboratory Cultural Resource Management Office FY 2010 Activity Report

    SciTech Connect

    Hollie K. Gilbert; Clayton F. Marler; Christina L. Olson; Brenda R. Pace; Julie Braun Williams

    2011-09-01

    The Idaho National Laboratory (INL) Site is home to vast numbers and a wide variety of important cultural resources representing at least a 13,500 year span of human land use in the region. As a federal agency, the Department of Energy, Idaho Operations Office (DOE-ID) has legal responsibility for the management and protection of the resources and has contracted these responsibilities to Battelle Energy Alliance (BEA). The BEA professional staff is committed to maintaining a cultural resource management program that accepts the challenge of preserving INL cultural resources in a manner reflecting their importance in local, regional, and national history. This report summarizes activities performed by the INL Cultural Resource Management Office (CRMO) staff during fiscal year 2010. This work is diverse, far-reaching and though generally confined to INL cultural resource compliance, also includes a myriad of professional and voluntary community activities. This document is intended to be informative to both internal and external stakeholders and to serve as a planning tool for future INL cultural resource management work.

  6. ITS as a data resource: Preliminary requirements for a user service

    SciTech Connect

    Margiotta, R.

    1998-04-01

    Contents of this report are: Executive Summary; Introduction; The Need for an Archived Data User Service; Technical and Institutional Issues for Implementation; Basic Requirements; Appendix A: Summary of Recent Data Needs Identification Efforts; Appendix B: Supplemental Information on the Long-Term Pavement Performance Traffic Data Structure.

  7. 48 CFR 352.239-72 - Security requirements for Federal information technology resources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... associated with their assigned positions. The Contractor shall comply with the HSPD-12 requirements contained...-furnished initial and refresher security and privacy education and awareness training before being granted...-owned systems used in contract performance. (k) Failure to comply. Failure on the part of the...

  8. Projections of costs, financing, and additional resource requirements for low- and lower middle-income country immunization programs over the decade, 2011-2020.

    PubMed

    Gandhi, Gian; Lydon, Patrick; Cornejo, Santiago; Brenzel, Logan; Wrobel, Sandra; Chang, Hugh

    2013-04-18

    The Decade of Vaccines Global Vaccine Action Plan has outlined a set of ambitious goals to broaden the impact and reach of immunization across the globe. A projections exercise has been undertaken to assess the costs, financing availability, and additional resource requirements to achieve these goals through the delivery of vaccines against 19 diseases across 94 low- and middle-income countries for the period 2011-2020. The exercise draws upon data from existing published and unpublished global forecasts, country immunization plans, and costing studies. A combination of an ingredients-based approach and use of approximations based on past spending has been used to generate vaccine and non-vaccine delivery costs for routine programs, as well as supplementary immunization activities (SIAs). Financing projections focused primarily on support from governments and the GAVI Alliance. Cost and financing projections are presented in constant 2010 US dollars (US$). Cumulative total costs for the decade are projected to be US$57.5 billion, with 85% for routine programs and the remaining 15% for SIAs. Delivery costs account for 54% of total cumulative costs, and vaccine costs make up the remainder. A conservative estimate of total financing for immunization programs is projected to be $34.3 billion over the decade, with country governments financing 65%. These projections imply a cumulative funding gap of $23.2 billion. About 57% of the total resources required to close the funding gap are needed just to maintain existing programs and scale up other currently available vaccines (i.e., before adding in the additional costs of vaccines still in development). Efforts to mobilize additional resources, manage program costs, and establish mutual accountability between countries and development partners will all be necessary to ensure the goals of the Decade of Vaccines are achieved. Establishing or building on existing mechanisms to more comprehensively track resources and

  9. Brine production strategy modeling for active and integrated management of water resources in CCS

    NASA Astrophysics Data System (ADS)

    Court, B.; Celia, M. A.; Nordbotten, J. M.; Buscheck, T. A.; Elliot, T. J.; Bandilla, K.; Dobossy, M.

    2010-12-01

    Our society is at present highly dependent on coal, which will continue to play a major role in baseload electricity production in the coming decades. Most projected climate change mitigation strategies require CO2 Capture and Sequestration (CCS) as a vital element to stabilize CO2 atmospheric emissions. In these strategies, CCS will have to expand in the next two decades by several orders of magnitude compared to current worldwide implementation. At present the interactions among freshwater extraction, CO2 injection, and brine management are being considered too narrowly across CCS operations, and in the case of freshwater almost completely overlooked. Following the authors’ recently published overview of these challenges, an active and integrated management of water resources throughout CCS operations was proposed to avoid overlooking critical challenges that may become major obstacles to CCS implementation. Water resources management is vital for several reasons including that a coal-fired power plant retrofitted for CCS requires twice as much cooling water as the original plant. However this increased demand may be accommodated by brine extraction and treatment, which would concurrently function as large-scale pressure management and a potential source of freshwater. Synergistic advantages of such proactive integration that were identified led the authors to concluded that: Active management of CCS operations through an integrated approach -including brine production, treatment, use for cooling, and partial reinjection- can address challenges simultaneously with several synergistic advantages; and, that freshwater and brine must be linked to CO2 and pressure as key decision making parameters throughout CCS operations while recognizing scalability and potential pore space competition challenges. This work presents a detailed modeling investigation of a potential integration opportunity resulting from brine production. Technical results will focus solely on the

  10. A National Assessment of the Potential Impacts of Hydraulic Fracturing Activities on Drinking Water Resources

    NASA Astrophysics Data System (ADS)

    Ridley, C.; Burden, S.; Fleming, M. M.; Knightes, C. D.; Koplos, J.; LeDuc, S. D.; Ring, S.; Stanek, J.; Tuccillo, M. E.; Weaver, J.; Frithsen, J.

    2015-12-01

    The U.S. Environmental Protection Agency recently released a draft assessment of the potential impacts of hydraulic fracturing on drinking water resources. As part of the draft assessment, we reviewed, analyzed, and synthesized information from over 950 sources and concluded that there are above and below ground mechanisms by which hydraulic fracturing activities have the potential to impact drinking water resources. These mechanisms include: Water withdrawals in times of, or in areas with, low water availability; Spills of hydraulic fracturing fluids and produced water; Fracturing directly into underground drinking water resources; Below ground migration of liquids and gases; and Inadequate treatment and discharge of wastewater. Of the potential mechanisms identified in this report, we found specific instances where one or more mechanisms led to impacts on drinking water resources, including contamination of drinking water wells. The number of identified cases, however, was small compared to the number of hydraulically fractured wells. This finding could reflect a rarity of effects on drinking water resources, but may also be due to other limiting factors. These factors include: insufficient pre- and post-fracturing data on the quality of drinking water resources; the paucity of long-term systematic studies; the presence of other sources of contamination precluding a definitive link between hydraulic fracturing activities and an impact; and the inaccessibility of some information on hydraulic fracturing activities and potential impacts. Disclaimer: The views expressed are those of the authors and do not necessarily reflect the views or polices of the EPA.

  11. Adult Active Transport in the Netherlands: An Analysis of Its Contribution to Physical Activity Requirements

    PubMed Central

    Fishman, Elliot; Böcker, Lars; Helbich, Marco

    2015-01-01

    Introduction Modern, urban lifestyles have engineered physical activity out of everyday life and this presents a major threat to human health. The Netherlands is a world leader in active travel, particularly cycling, but little research has sought to quantify the cumulative amount of physical activity through everyday walking and cycling. Methods Using data collected as part of the Dutch National Travel Survey (2010 – 2012), this paper determines the degree to which Dutch walking and cycling contributes to meeting minimum level of physical activity of 150 minutes of moderate intensity aerobic activity throughout the week. The sample includes 74,465 individuals who recorded at least some travel on the day surveyed. As physical activity benefits are cumulative, all walking and cycling trips are analysed, including those to and from public transport. These trips are then converted into an established measure of physical activity intensity, known as metabolic equivalents of tasks. Multivariate Tobit regression models were performed on a range of socio-demographic, transport resources, urban form and meteorological characteristics. Results The results reveal that Dutch men and women participate in 24 and 28 minutes of daily physical activity through walking and cycling, which is 41% and 55% more than the minimum recommended level. It should be noted however that some 57% of the entire sample failed to record any walking or cycling, and an investigation of this particular group serves as an important topic of future research. Active transport was positively related with age, income, bicycle ownership, urban density and air temperature. Car ownership had a strong negative relationship with physically active travel. Conclusion The results of this analysis demonstrate the significance of active transport to counter the emerging issue of sedentary lifestyle disease. The Dutch experience provides other countries with a highly relevant case study in the creation of

  12. Learning Activities and Resource Units: Intermediate 4-8. [Arizona] Migrant Child Institute.

    ERIC Educational Resources Information Center

    Wheelock, Warren H., Ed.

    A requirement of Arizona's Migrant Teacher Institutes was the preparation of instructional resource units. Development of these units was a key element in the three-stage recommendations related to individualizing instruction in both reading and oral language. The three stages were: Room Organization--Realistic Learning Centers, Unit Themes and…

  13. 32 CFR Enclosure 2 - Requirements for Environmental Considerations-Foreign Nations and Protected Global Resources

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (Manpower, Reserve Affairs, and Logistics). (5) The activities of the intelligence components utilized by... Defense Intelligence Agency, the National Security Agency, the offices for the collection of specialized intelligence through reconnaissance programs, the Army Office of the Assistant Chief of Staff for...

  14. Requirements, Resource Planning and Management for Decrewing/Recrewing Scenarios of the International Space Station

    NASA Astrophysics Data System (ADS)

    Bach, David A.; Brand, Susan N.; Hasbrook, Peter V.

    2013-09-01

    Following the failure of 44 Progress (44P) on launch in August 2011, and the subsequent grounding of all Russian Soyuz rocket based launches, the International Space Station (ISS) ground teams engaged in an effort to determine how long the ISS could remain crewed, what would be required to safely configure the ISS for decrewing, and what would be required to recrew the ISS upon resumption of Soyuz rocket launches if decrewing became necessary. This White Paper was written to capture the processes and lessons learned from real-time time events and to provide a reference and training document for ISS Program teams in the event decrewing of the ISS is needed.Through coordination meetings and assessments, teams identified six decrewing priorities for ground and crew operations. These priorities were integrated along with preflight priorities through the Increment re-planning process. Additionally, the teams reviewed, updated, and implemented changes to the governing documentation for the configuration of the ISS for a contingency decrewing event. Steps were taken to identify critical items for disposal prior to decrewing, as well as identifying the required items to be strategically staged or flown with the astronauts and cosmonauts who would eventually recrew the ISS.After the successful launches and dockings of both 45P and 28 Soyuz (28S), the decrewing team transitioned to finalizing and publishing the documentation for standardizing the decrewing flight rules. With the continued launching of crews and cargo to the ISS, utilization and science is again a high priority; both Increment pairs 29 and 30, and Increment 31 and 32 reaching the milestone of at least 35 hours per week average utilization.

  15. Requirements, Resource Planning, and Management for Decrewing/Recrewing Scenarios of the International Space Station

    NASA Technical Reports Server (NTRS)

    Bach, David A.; Brand, Susan N.; Hasbrook, Peter V.

    2013-01-01

    Following the failure of 44 Progress (44P) on launch in August 2011, and the subsequent grounding of all Russian Soyuz rocket based launches, the International Space Station (ISS) ground teams engaged in an effort to determine how long the ISS could remain crewed, what would be required to safely configure the ISS for decrewing, and what would be required to recrew the ISS upon resumption of Soyuz rocket launches if decrewing became necessary. This White Paper was written to capture the processes and lessons learned from real-time time events and to provide a reference and training document for ISS Program teams in the event decrewing of the ISS is needed. Through coordination meetings and assessments, teams identified six decrewing priorities for ground and crew operations. These priorities were integrated along with preflight priorities through the Increment re-planning process. Additionally, the teams reviewed, updated, and implemented changes to the governing documentation for the configuration of the ISS for a contingency decrewing event. Steps were taken to identify critical items for disposal prior to decrewing, as well as identifying the required items to be strategically staged or flown with the astronauts and cosmonauts who would eventually recrew the ISS. After the successful launches and dockings of both 45P and 28 Soyuz (28S), the decrewing team transitioned to finalizing and publishing the documentation for standardizing the decrewing flight rules. With the continued launching of crews and cargo to the ISS, utilization and science is again a high priority; both Increment pairs 29 and 30, and Increment 31 and 32 reaching the milestone of at least 35 hours per week average utilization.

  16. Requirements, Resource Planning and Management for Decrewing/Recrewing Scenarios of the International Space Station

    NASA Technical Reports Server (NTRS)

    Bach, David A.; Hasbrook, Peter V.; BBrand, Susan N.

    2012-01-01

    Following the failure of 44P on launch in August 2011, and the subsequent grounding of all Russian Soyuz rocket based launches, the ISS ground teams engaged in an effort to determine how long the ISS could remain crewed, what would be required to safely configure the ISS for decrewing, and what would be required to recrew the ISS upon resumption of Soyuz rocket launches if decrewing became necessary. This White Paper was written to capture the processes and lessons learned from real-time time events and to provide a reference and training document for ISS Program teams in the event decrewing of the ISS is needed. Through coordination meetings and assessments, teams identified six decrewing priorities for ground and crew operations. These priorities were integrated along with preflight priorities through the Increment replanning process. Additionally, the teams reviewed, updated, and implemented changes to the governing documentation for the configuration of the ISS for a contingency decrewing event. Steps were taken to identify critical items for disposal prior to decrewing, as well as identifying the required items to be strategically staged or flown with the astronauts and cosmonauts who would eventually recrew the ISS. After the successful launches and dockings of both 45P and 28S, the decrewing team transitioned to finalizing and publishing the documentation for standardizing the decrewing flight rules. With the continued launching of crews and cargo to the ISS, utilization and science is again a high priority, with the Increment pairs 29 and 30, and 31 and 32 reaching the milestone of at least 35 hours per week average utilization.

  17. Board on Earth Sciences and Resources and Its Activities -- Final Technical Report

    SciTech Connect

    Anthony R. de Souza, Ph.D. Director, Board on Earth Sciences and Resources

    2003-09-26

    The Board on Earth Sciences and Resources (BESR) provided oversight of the earth sciences and resources activities with the National Research Council (NRC). The Board reviewed research and public activities in the earth sciences; undertook analyses relevant to the discovery, supply, delivery, waste disposal and associated impacts and issues related to hydrocarbon, metallic, and nonmetallic mineral resources; and monitored the status of the earth sciences, assessed the health of the disciplines, identified research opportunities, and responded to specific agency requests for advice. These tasks were conducted by distinguished volunteers and NRC staff members that are representative of the breadth and depth of the earth sciences and resources disciplines (e.g., ecology, geophysics, geochemistry, geobiology, hydrology, geography, geographic information science, materials science, mineral resources and mining, energy resources, paleontology, visualization, remote sensing, geophysical data and information). Each year the Board held two meetings. Most recently at the May 2003 Board meeting, the main topic of discussion was Coordination of Geospatial Data in the Era of the Department of Homeland Security. Speakers were Steven Cooper, DHS; Barry Napier, FEMA; Bill Shinar, VGIN; Barbara Ryan, USGS; and Hank Garie, DOI. Other topics were Circum-Pacific Council for Energy and Mineral Resources and New Opportunities in the Geology Discipline (Pat Leahy, USGS); Challenges to Understanding Biological Change in a Fluid Landscape (Sue Haseltine, USGS); and GIS and Remote Sensing at the USDA (Rodney Brown, USDA). The Board and the AGI also held a Leadership Forum. At the October 2003 Board meeting in Irvine, California, the Board plans to discuss earth resource issues, develop a white paper on the future directions of the Board, and review two of its standing committees--Committee on Seismology and Geodynamics, and the Committee on Geological and Geotechnical Engineering. The Board

  18. Global socioeconomic material stocks rise 23-fold over the 20th century and require half of annual resource use.

    PubMed

    Krausmann, Fridolin; Wiedenhofer, Dominik; Lauk, Christian; Haas, Willi; Tanikawa, Hiroki; Fishman, Tomer; Miatto, Alessio; Schandl, Heinz; Haberl, Helmut

    2017-02-21

    Human-made material stocks accumulating in buildings, infrastructure, and machinery play a crucial but underappreciated role in shaping the use of material and energy resources. Building, maintaining, and in particular operating in-use stocks of materials require raw materials and energy. Material stocks create long-term path-dependencies because of their longevity. Fostering a transition toward environmentally sustainable patterns of resource use requires a more complete understanding of stock-flow relations. Here we show that about half of all materials extracted globally by humans each year are used to build up or renew in-use stocks of materials. Based on a dynamic stock-flow model, we analyze stocks, inflows, and outflows of all materials and their relation to economic growth, energy use, and CO2 emissions from 1900 to 2010. Over this period, global material stocks increased 23-fold, reaching 792 Pg (±5%) in 2010. Despite efforts to improve recycling rates, continuous stock growth precludes closing material loops; recycling still only contributes 12% of inflows to stocks. Stocks are likely to continue to grow, driven by large infrastructure and building requirements in emerging economies. A convergence of material stocks at the level of industrial countries would lead to a fourfold increase in global stocks, and CO2 emissions exceeding climate change goals. Reducing expected future increases of material and energy demand and greenhouse gas emissions will require decoupling of services from the stocks and flows of materials through, for example, more intensive utilization of existing stocks, longer service lifetimes, and more efficient design.

  19. Global socioeconomic material stocks rise 23-fold over the 20th century and require half of annual resource use

    PubMed Central

    Wiedenhofer, Dominik; Lauk, Christian; Haas, Willi; Tanikawa, Hiroki; Miatto, Alessio; Haberl, Helmut

    2017-01-01

    Human-made material stocks accumulating in buildings, infrastructure, and machinery play a crucial but underappreciated role in shaping the use of material and energy resources. Building, maintaining, and in particular operating in-use stocks of materials require raw materials and energy. Material stocks create long-term path-dependencies because of their longevity. Fostering a transition toward environmentally sustainable patterns of resource use requires a more complete understanding of stock-flow relations. Here we show that about half of all materials extracted globally by humans each year are used to build up or renew in-use stocks of materials. Based on a dynamic stock-flow model, we analyze stocks, inflows, and outflows of all materials and their relation to economic growth, energy use, and CO2 emissions from 1900 to 2010. Over this period, global material stocks increased 23-fold, reaching 792 Pg (±5%) in 2010. Despite efforts to improve recycling rates, continuous stock growth precludes closing material loops; recycling still only contributes 12% of inflows to stocks. Stocks are likely to continue to grow, driven by large infrastructure and building requirements in emerging economies. A convergence of material stocks at the level of industrial countries would lead to a fourfold increase in global stocks, and CO2 emissions exceeding climate change goals. Reducing expected future increases of material and energy demand and greenhouse gas emissions will require decoupling of services from the stocks and flows of materials through, for example, more intensive utilization of existing stocks, longer service lifetimes, and more efficient design. PMID:28167761

  20. Resource Allocation Scheme in MIMO-OFDMA System for User's Different Data Throughput Requirements

    NASA Astrophysics Data System (ADS)

    Sann Maw, Maung; Sasase, Iwao

    In the subcarrier and power allocation schemes in Multi-Input Multi-Output and Orthogonal Frequency Division Multiple Access (MIMO-OFDMA) systems, only equal fairness among users has been considered and no scheme for proportional data rate fairness has been considered. In this paper, a subcarrier, bit and power allocation scheme is proposed to maximize the total throughput under the constraints of total power and proportional data rate fairness among users. In the proposed scheme, joint subchannel allocation and adaptive bit loading is firstly performed by using singular value decomposition (SVD) of channel matrix under the constraint of users' data throughput requirements, and then adaptive power loading is applied. Simulation results show that effective performance of the system has been improved as well as each throughput is proportionally distributed among users in MIMO-OFDMA systems.

  1. Sustainable resource use requires “clean cycles” and safe “final sinks”

    PubMed Central

    Kral, Ulrich; Kellner, Katharina; Brunner, Paul H.

    2013-01-01

    In order to fulfill the objectives of environmental protection, today's focus on quantitative recycling rates must be amended by a more qualitative approach. Because modern products represent a mix of numerous and sometimes hazardous substances, ways must be explored to remove detrimental substances during recycling and to establish “clean cycles”. On the one hand, such a “clean cycle” strategy will result in better recycling qualities of secondary products and less dissipation of hazardous substances during further product use. On the other hand, the elimination of hazardous substances during recycling requires sinks for the disposal of the eliminated materials. These topics are presented in general as well as by case studies. In particular, the sink issue is addressed, differentiating between sinks and final sinks and discussing the challenge to supply appropriate final sinks for all materials that cannot be recycled. PMID:23017730

  2. NASA's SMD Cross-Forum Resources for Supporting Scientist Engagement in Education and Public Outreach Activities

    NASA Astrophysics Data System (ADS)

    Buxner, S.; Cobabe-Ammann, E. A.; Hsu, B. C.; Sharma, M.; Peticolas, L. M.; Schwerin, T. G.; Shipp, S. S.; Smith, D.

    2012-12-01

    Sharing the excitement of ongoing scientific discoveries is an important aspect of scientific activity for researchers. Directly engaging scientists in education and public outreach (E/PO) activities has the benefit of directly connecting the public to those who engage in scientific activities. A shortage of training in education methods, public speaking, and working with various public audiences increases barriers to engaging scientists in these types in E/PO activities. NASA's Science Mission Directorate (SMD) Education and Public forums (astrophysics, earth science, heliophysics, and planetary science) support scientists currently involved in E/PO and who are interested in becoming involved in E/PO through a variety of avenues. Over the past three years, the forums have developed a variety of resources to help engage scientists in education and public outreach. We will showcase the following resources developed through the SMD E/PO cross-forum efforts: Professional development resources for writing NASA SMD E/PO proposals (webinars and other online tools), ongoing professional development at scientific conferences to increase scientist engagement in E/PO activities, toolkits for scientists interested in best practices in E/PO (online guides for K-12 education and public outreach), toolkits to inform scientists of science education resources developed within each scientific thematic community, EarthSpace (a community web space where instructors can find and share about teaching space and earth sciences in the undergraduate classroom, including class materials news and funding opportunities, and the latest education research, http://www.lpi.usra.edu/earthspace/), thematic resources for teaching about SMD science topics, and an online database of scientists interested in connecting with education programs. Learn more about the Forum and find resources at http://smdepo.org/.

  3. 12 CFR 1272.3 - New business activity notice requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... targeted by the activity; (iii) The delivery system for the activity; and (iv) The effect of the activity... chapter; and (4) A demonstration of the Bank's capacity, personnel, technology, experience and...

  4. Framing as a cultural resource in health social movements: funding activism and the breast cancer movement in the US 1990-1993.

    PubMed

    Kolker, Emily S

    2004-09-01

    Disease-specific funding activism in the US has required health social movements (HSMs) to draw on both structural and cultural resources in order to persuade audiences and to redefine dominant conceptions of disease. Using a social constructionist analysis of Congressional testimony and media accounts of breast cancer funding activism between 1990-1993, this paper demonstrates that the use of culturally resonant frames served as an important cultural resource for breast cancer activists in the early 1990s. The breast cancer movement's use of three interconnected and culturally resonant frames aided the movement in redefining breast cancer as a problem of individual women to a major public health problem in need of governmental attention. This research contributes to both social movement and HSM scholarship by demonstrating that cultural resources, in the form of movement frames, are as central to social movement analysis as structural resources.

  5. Resources Required for Cervical Cancer Prevention in Low- and Middle-Income Countries

    PubMed Central

    Campos, Nicole G.; Sharma, Monisha; Clark, Andrew; Kim, Jane J.; Resch, Stephen C.

    2016-01-01

    Background Cervical cancer is the fourth leading cause of cancer death in women, with 85% of cases and deaths occurring in developing countries. While organized screening programs have reduced cervical cancer incidence in high-income countries through detection and treatment of precancerous lesions, the implementation of organized screening has not been effective in low-resource settings due to lack of infrastructure and limited budgets. Our objective was to estimate the cost of comprehensive primary and secondary cervical cancer prevention in low- and middle-income countries. Methods and Findings We performed a modeling analysis to estimate 1) for girls aged 10 years, the cost of 2-dose human papillomavirus (HPV) vaccination; and 2) for women aged 30 to 49 years, the cost of cervical cancer screening (with visual inspection with acetic acid (VIA), HPV testing, or cytology) and preventive treatment in 102 low- and middle-income countries from 2015 to 2024. We used an Excel-based costing and service utilization model to estimate financial costs (2013 US$) based on prevalence of HPV, prevalence of precancerous lesions, and screening test performance. Where epidemiologic data were unavailable, we extrapolated from settings with data using an individual-based microsimulation model of cervical carcinogenesis (calibrated to 20 settings) and multivariate regression. Total HPV vaccination costs ranged from US$8.6 billion to US$24.2 billion for all scenarios considered (immediate, 5-year, or 10-year roll-out; price per dose US$4.55-US$70 by country income level). The total cost of screening and preventive treatment ranged from US$5.1 billion (10-year roll-out, screening once at age 35 years) to US$42.3 billion (immediate roll-out, high intensity screening). Limitations of this analysis include the assumption of standardized protocols by country income level that did not account for the potential presence of multiple screening modalities or management strategies within a

  6. Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration

    SciTech Connect

    Arulanandam, Rozanne; Geletu, Mulu; Feracci, Helene; Raptis, Leda

    2010-03-10

    Rac1 (Rac) is a member of the Rho family of small GTPases which controls cell migration by regulating the organization of actin filaments. Previous results suggested that mutationally activated forms of the Rho GTPases can activate the Signal Transducer and Activator of Transcription-3 (Stat3), but the exact mechanism is a matter of controversy. We recently demonstrated that Stat3 activity of cultured cells increases dramatically following E-cadherin engagement. To better understand this pathway, we now compared Stat3 activity levels in mouse HC11 cells before and after expression of the mutationally activated Rac1 (Rac{sup V12}), at different cell densities. The results revealed for the first time a dramatic increase in protein levels and activity of both the endogenous Rac and Rac{sup V12} with cell density, which was due to inhibition of proteasomal degradation. In addition, Rac{sup V12}-expressing cells had higher Stat3, tyrosine-705 phosphorylation and activity levels at all densities, indicating that Rac{sup V12} is able to activate Stat3. Further examination of the mechanism of Stat3 activation showed that Rac{sup V12} expression caused a surge in mRNA of Interleukin-6 (IL6) family cytokines, known potent Stat3 activators. Knockdown of gp130, the common subunit of this family reduced Stat3 activity, indicating that these cytokines may be responsible for the Stat3 activation by Rac{sup V12}. The upregulation of IL6 family cytokines was required for cell migration and proliferation induced by Rac{sup V12}, as shown by gp130 knockdown experiments, thus demonstrating that the gp130/Stat3 axis represents an essential effector of activated Rac for the regulation of key cellular functions.

  7. New State Forest Practice Laws. A review of state laws and their natural resource data requirements

    NASA Technical Reports Server (NTRS)

    Klein, S. B.

    1980-01-01

    Forest practice regulations can be established by being specified in state law or by being promulgated by some other official body delegated the authority to do so. At the state level, public regulation of private forest practices resulted in many cases, in the enactment of state forest practice laws regulating both private, and in some cases, public landowner activities. These laws aim not only to protect natural environments, but also to encourage continuous productivity of forest lands, to maintain or enhance aesthetic values, and to serve as an implementing mechanism to control water pollution. Profiles of regulations in California, Idaho, Maine, Nevada, New Hampshire, Oregon, and Washington are examined and assessed. Voluntary guidelines in use in 18 states are summarized.

  8. Somali Perspectives on Physical Activity: Photovoice to Address Barriers and Resources in San Diego

    PubMed Central

    Murray, Kate; Mohamed, Amina Sheik; Dawson, Darius B.; Syme, Maggie; Abdi, Sahra; Barnack-Tavlaris, Jessica

    2015-01-01

    Background Though many immigrants enter the U.S. with a healthy body weight, this health advantage disappears the longer they reside in the U.S. To better understand the complexities of obesity change within a cultural framework, a community-based participatory research (CBPR) approach, Photovoice, was utilized focusing on physical activity among Muslim Somali women. Objectives The CBPR partnership was formed to identify barriers and resources to engaging in physical activity with goals of advocacy and program development. Methods Muslim Somali women (n = 8) were recruited to participate, trained and provided cameras, and engaged in group discussions about the scenes they photographed. Results Participants identified several barriers, including safety concerns, minimal culturally appropriate resources, and financial constraints. Strengths included public resources and a community support system. The CBPR process identified opportunities and challenges to collaboration and dissemination processes. Conclusions The findings laid the framework for subsequent program development and community engagement. PMID:25981428

  9. Full-term newborns with normal birth weight requiring special care in a resource-constrained setting

    PubMed Central

    Olusanya, Bolajoko O.

    2013-01-01

    Introduction The level of clinical care and facilities to support the often more viable full-term newborns with normal birth weight compared with preterm/low birth weight newborns that require special care at birth are likely to be attainable in many resource-poor settings. However, the nature of the required care is not evident in current literature. This study therefore set out to determine maternal and perinatal profile of surviving full-term newborns with normal birth weight in a poorly-resourced setting. Methods A retrospective cohort study of newborns with gestational age ≥37 weeks and birth weight ≥2500g recruited in an inner-city maternity hospital in Lagos, Nigeria. Primary factors/outcomes were determined by multivariate logistic regression analyses and population attributable risk (PAR). Results Of the 2687 full-term newborns with normal birth weight studied, 242 (9.0%) were admitted into special care baby unit (SCBU) representing 53.6% of all SCBU admissions. Fetal distress, low 5-minute Apgar scores, neonatal sepsis and hyperbilirubinemia as well as maternal factors such as primiparity, type of employment, lack of antenatal care and emergency cesarean delivery were predictive of SCBU admission. The leading contributors to SCBU admission were neonatal sepsis (PAR=96.8%), and hyperbilirubinemia (PAR=58.7%). Conclusion A significant proportion of newborns requiring special care are full-term with normal birth weight and are associated with modifiable risk factors that can be effectively addressed at appropriately equipped secondary-level hospitals. Prenatal maternal education on avoidable risk factors is warranted. PMID:24062865

  10. Astronomical! 44 Activities, Experiments, and Projects. Classroom Resource 0-27440.

    ERIC Educational Resources Information Center

    Walker, Ormiston H.

    This is a resource book for four major areas of study: basic astronomy, a star's life, the planets, and the atmosphere. The activities and demonstrations included can be done in a classroom setting during the day by using readily available materials. Topics covered include: refracting and reflecting telescopes, star finder, circumpolar…

  11. Activities of the Alaska District, Water Resources Division, U.S. Geological Survey, 1990

    USGS Publications Warehouse

    Snyder, Elisabeth F.

    1990-01-01

    Thirteen projects of the U.S. Geological Survey, Water Resource Division active in Alaska in 1990 are described. Each description includes information on period of project, chief, funding sources, location, purpose, current status, and published or planned reports. The compilation also contains a bibliography of reports published by the Alaska District from 1987 through January 1990. (USGS)

  12. Stream mesocosm response sensitivities to simulated ion stress in produced waters from resource extraction activities

    EPA Science Inventory

    To increase the ecological relevance of laboratory exposures intent on determining species sensitivity to ion stress from resource extraction activities we have conducted several stream mesocosm dosing studies that pair single-species and community-level responses in-situ and all...

  13. Our Working World: Cities at Work. Text, Resource Unit, and Activity Book, Teacher's Edition.

    ERIC Educational Resources Information Center

    Senesh, Lawrence

    This unit of 22 related items includes a text, activity book, resource book, workbook, records, and filmstrips, all dealing with the history, present, and future of cities. The program tries to involve third grade children in the cities' problems by helping them feel they should participate in discovering the causes of the major problems cities…

  14. Manpower and Financial Resources Allocated to Academic Science and Engineering Activities, 1965-71.

    ERIC Educational Resources Information Center

    National Science Foundation, Washington, DC. Div. of Science Resources Studies.

    This report summarizes the results of the National Science Foundation's biennial survey of manpower and financial resources for scientific engineering activities at institutions of higher education, 1971. The survey was conducted by mail questionnaires sent to 2,198 universities and colleges that maintained science and engineering programs, and…

  15. Technology in College Unions and Student Activities: A Collection of Technology Resources from the ACUI Community

    ERIC Educational Resources Information Center

    Association of College Unions International (NJ1), 2012

    2012-01-01

    This publication presents a collection of technology resources from the Association of College Unions International (ACUI) community. Contents include: (1) Podcasting (Jeff Lail); (2) Video Podcasting (Ed Cabellon); (3) Building a Multimedia Production Center (Nathan Byrer); (4) Cloud Computing in the Student Union and Student Activities (TJ…

  16. Global Issues: Activities and Resources for the High School Teacher. Second Edition.

    ERIC Educational Resources Information Center

    Switzer, Kenneth A.; And Others

    Increasing student knowledge about other nations and interrelationships with them is the primary goal of this teaching guide. The activities and resources focus on six topics of continuing global importance: (1) trade and economic issues, (2) conflict and armaments, (3) modernization and development, (4) technology and the environment, (5) energy,…

  17. Small Schools Mathematics Curriculum, 9-12: Scope Objectives, Activities, Resources, Monitoring Procedures.

    ERIC Educational Resources Information Center

    Nelson, JoAnne, Ed.; And Others

    The grade 9-12 mathematics curriculum learning objectives, activities, monitoring procedures and resources for small schools were developed during 1978-79 through the cooperative efforts of 10 Snohomish and Island County school districts, Educational Service District 189 and the Washington State Office of Public Instruction. The objectives were…

  18. 30 CFR 551.8 - Inspection and reporting requirements for activities under a permit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., aquatic life, archaeological resources, or other uses of the area. BOEM will reimburse you for food... modifications. Before you begin modified operations, you must submit a written request describing the... activities on the environment, aquatic life, archaeological resources, or other uses of the area in which...

  19. 30 CFR 551.8 - Inspection and reporting requirements for activities under a permit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., aquatic life, archaeological resources, or other uses of the area. BOEM will reimburse you for food... modifications. Before you begin modified operations, you must submit a written request describing the... activities on the environment, aquatic life, archaeological resources, or other uses of the area in which...

  20. 20 CFR 665.330 - Are the NAFTA-TAA program requirements for rapid response also required activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Are the NAFTA-TAA program requirements for... WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.330 Are the NAFTA-TAA program requirements for... WIA are made available to workers who, under the NAFTA Implementation Act (Public Law 103-182),...

  1. 20 CFR 665.330 - Are the NAFTA-TAA program requirements for rapid response also required activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Are the NAFTA-TAA program requirements for... WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.330 Are the NAFTA-TAA program requirements for... WIA are made available to workers who, under the NAFTA Implementation Act (Public Law 103-182),...

  2. Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site.

    PubMed

    Roberts, Kenneth M; Khan, Crystal A; Hinck, Cynthia S; Fitzpatrick, Paul F

    2014-12-16

    Phenylalanine hydroxylase (PheH), a liver enzyme that catalyzes the hydroxylation of excess phenylalanine in the diet to tyrosine, is activated by phenylalanine. The lack of activity at low levels of phenylalanine has been attributed to the N-terminus of the protein's regulatory domain acting as an inhibitory peptide by blocking substrate access to the active site. The location of the site at which phenylalanine binds to activate the enzyme is unknown, and both the active site in the catalytic domain and a separate site in the N-terminal regulatory domain have been proposed. Binding of catecholamines to the active-site iron was used to probe the accessibility of the active site. Removal of the regulatory domain increases the rate constants for association of several catecholamines with the wild-type enzyme by ∼2-fold. Binding of phenylalanine in the active site is effectively abolished by mutating the active-site residue Arg270 to lysine. The k(cat)/K(phe) value is down 10⁴ for the mutant enzyme, and the K(m) value for phenylalanine for the mutant enzyme is >0.5 M. Incubation of the R270K enzyme with phenylalanine also results in a 2-fold increase in the rate constants for catecholamine binding. The change in the tryptophan fluorescence emission spectrum seen in the wild-type enzyme upon activation by phenylalanine is also seen with the R270K mutant enzyme in the presence of phenylalanine. Both results establish that activation of PheH by phenylalanine does not require binding of the amino acid in the active site. This is consistent with a separate allosteric site, likely in the regulatory domain.

  3. Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons

    PubMed Central

    Kim, SangSeong; Ma, Limei; Yu, C. Ron

    2011-01-01

    In terrestrial vertebrates, the vomeronasal organ (VNO) detects and transduces pheromone signals. VNO activation is thought to be mediated by the transient receptor potential C2 (TRPC2) channel. The aberrant behavioural phenotypes observed in TRPC2−/− mice are generally attributed to the lost VNO function. Recently, calcium-activated chloride channels have been shown to contribute to VNO activation. Here we show that CACCs can be activated in VNO slice preparations from the TRPC2−/− mice and this activation is blocked by pharmacological agents that inhibit intracellular Ca2+ release. Urine-evoked Cl− current is sufficient to drive spiking changes in VNO neurons from both wild-type (WT) and TRPC2−/− mice. Moreover, blocking Cl− conductance essentially abolishes VNO activation in WT neurons. These results suggest a TRPC2-independent signalling pathway in the VNO and the requirement of calcium-activated chloride channels currents to mediate pheromone activation. Our data further suggest that TRPC2−/− mice retain partial VNO function. PMID:21694713

  4. Advanced Extra-Vehicular Activity Pressure Garment Requirements Development

    NASA Technical Reports Server (NTRS)

    Ross, Amy; Aitchison, Lindsay; Rhodes, Richard

    2015-01-01

    The NASA Johnson Space Center advanced pressure garment technology development team is addressing requirements development for exploration missions. Lessons learned from the Z-2 high fidelity prototype development have reiterated that clear low-level requirements and verification methods reduce risk to the government, improve efficiency in pressure garment design efforts, and enable the government to be a smart buyer. The expectation is to provide requirements at the specification level that are validated so that their impact on pressure garment design is understood. Additionally, the team will provide defined verification protocols for the requirements. However, in reviewing exploration space suit high level requirements there are several gaps in the team's ability to define and verify related lower level requirements. This paper addresses the efforts in requirement areas such as mobility/fit/comfort and environmental protection (dust, radiation, plasma, secondary impacts) to determine the method by which the requirements can be defined and use of those methods for verification. Gaps exist at various stages. In some cases component level work is underway, but no system level effort has begun; in other cases no effort has been initiated to close the gap. Status of on-going efforts and potential approaches to open gaps are discussed.

  5. 25 CFR 262.4 - Activities by Indian tribes or individuals that require a permit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... require a permit. (a) No Indian tribe may, without a permit under the Act, excavate or remove... permit under the Act, excavate or remove archaeological resources on any Indian lands (including his or... Indian tribe, shall be exempt from the permit requirements of the Act, except in the cases listed...

  6. 25 CFR 262.4 - Activities by Indian tribes or individuals that require a permit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... require a permit. (a) No Indian tribe may, without a permit under the Act, excavate or remove... permit under the Act, excavate or remove archaeological resources on any Indian lands (including his or... Indian tribe, shall be exempt from the permit requirements of the Act, except in the cases listed...

  7. 25 CFR 262.4 - Activities by Indian tribes or individuals that require a permit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... require a permit. (a) No Indian tribe may, without a permit under the Act, excavate or remove... permit under the Act, excavate or remove archaeological resources on any Indian lands (including his or... Indian tribe, shall be exempt from the permit requirements of the Act, except in the cases listed...

  8. 43 CFR 5.4 - When is a permit required for news-gathering activities?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false When is a permit required for news... Wildlife Service § 5.4 When is a permit required for news-gathering activities? (a) Permit requirements. News-gathering activities involving filming, videography, or still photography do not require a...

  9. 43 CFR 5.4 - When is a permit required for news-gathering activities?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false When is a permit required for news... Wildlife Service § 5.4 When is a permit required for news-gathering activities? (a) Permit requirements. News-gathering activities involving filming, videography, or still photography do not require a...

  10. Soil erosion and sediment control laws. A review of state laws and their natural resource data requirements

    NASA Technical Reports Server (NTRS)

    Klein, S. B.

    1980-01-01

    Twenty states, the District of Columbia, and the Virgin Islands enacted erosion and sediment control legislation during the past decade to provide for the implementation or the strengthening of statewide erosion and sediment control plans for rural and/or urban lands. That legislation and the state programs developed to implement these laws are quoted and reviewed. The natural resource data requirements of each program are also extracted. The legislation includes amendments to conservation district laws, water quality laws, and erosion and sediment control laws. Laws which provides for legislative review of administrative regulations and LANDSAT applications and/or information systems that were involved in implementing or gathering data for a specific soil erosion and sediment control program are summarized as well as principal concerns affecting erosion and sediment control laws.

  11. 20 CFR 665.330 - Are the NAFTA-TAA program requirements for rapid response also required activities?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Are the NAFTA-TAA program requirements for... TITLE I OF THE WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.330 Are the NAFTA-TAA program... activities under WIA are made available to workers who, under the NAFTA Implementation Act (Public Law...

  12. 20 CFR 665.330 - Are the NAFTA-TAA program requirements for rapid response also required activities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Are the NAFTA-TAA program requirements for... TITLE I OF THE WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.330 Are the NAFTA-TAA program... activities under WIA are made available to workers who, under the NAFTA Implementation Act (Public Law...

  13. 20 CFR 665.330 - Are the NAFTA-TAA program requirements for rapid response also required activities?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Are the NAFTA-TAA program requirements for... TITLE I OF THE WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.330 Are the NAFTA-TAA program... activities under WIA are made available to workers who, under the NAFTA Implementation Act (Public Law...

  14. Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. Requires metabolic activation.

    PubMed

    Winuthayanon, Wipawee; Suksen, Kanoknetr; Boonchird, Chuenchit; Chuncharunee, Aporn; Ponglikitmongkol, Mathurose; Suksamrarn, Apichart; Piyachaturawat, Pawinee

    2009-02-11

    Curcuma comosa Roxb. has traditionally been used as a dietary supplement for health promotion in peri- and postmenopausal women in Thailand. We investigated the estrogenic activity of 7 naturally occurring diarylheptanoids from the extracts of C. comosa both in vitro and in vivo. A yeast recombinant system containing human estrogen receptor alpha, coactivator TIF2 and a beta-galactosidase reporter gene was used to determine estrogenic activity of diarylheptanoids metabolically activated with rat liver S9-fraction prior to the assay. The most potent compound was (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol, with a relative potency of 4% compared to 17beta-estradiol. The metabolic activation of diarylheptanoids markedly enhanced their efficiency. The chemical structure required for estrogenic activity of diarylheptanoids was the presence of a keto group at C3 and absence of hydroxyl moiety in ring B. Only diarylheptanoids showing full estrogenic efficiency in vitro were able to elicit uterotrophic activity of in immature ovariectomized rat. This is the first evidence for in vivo estrogenic activity of diarylheptanoids from C. comosa. This novel class of natural phytoestrogens has the potential to be developed for use as dietary supplement in the treatment of menopausal symptoms.

  15. Understanding How Resources and Capabilities Affect Performance: Actively Applying the Resource-Based View in the Classroom

    ERIC Educational Resources Information Center

    Sheehan, Norman T.

    2006-01-01

    The resource-based view is a strategic framework for understanding why some firms outperform others. Its importance is reflected in its wide inclusion in strategy texts as a tool for assessing a firm's internal strengths and weaknesses. This article outlines an experiential exercise that demonstrates how different bundles of resources and…

  16. Social activities of older men who require daily support and the purpose of such activities.

    PubMed

    Hirano, Michiyo; Saeki, Kazuko; Ueda, Izumi; Honda, Hikaru; Mizuno, Yoshiko

    2017-01-01

    Objectives The purpose of this study was to analyze the social activities of older men who require daily support, and to clarify the purpose of such activities, in order to develop effective living support and preventive long-term care service, suitable for this population.Methods Individual, semi-structured interviews were conducted with 17 older men. Data were analyzed using inductive and qualitative methods.Results Four categories of social activities were identified, and four categories of purposes of these social activities were extracted. The following were the identified social activities: maintenance of "comfortable relationships with others," including family, relatives, friends, and neighbors; "participation and use of services and programs with clear objectives and relationships with others," such as long-term care insurance system services, clubs for the elderly, and hobby groups; maintenance of "relationships with former colleagues, depending on their experience of working with them," where some individuals actively participated in gatherings with former colleagues, while others did not keep in touch at all; and participation in "activities to enrich their feelings and quality of life within their living space," such as reading, watching TV, and doing household chores. The purposes of the observed social activities were to build "relationships with society through communication with other people" and to have a "sense of security by spending time with people of the same age and with those older than them." Hence, participants engaged in clubs for the elderly, as well as in hobby groups. In addition, participants made time for exercising regularly, which maintained their cognitive function and was intended for the "maintenance and activation of their physical functions by continuing to exercise," and "continuing to learn by thinking." Furthermore, participants engaged in the exercise or hobby groups that they were interested in, in order to

  17. 40 CFR 232.3 - Activities not requiring permits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... section. Activities on areas lying fallow as part of a conventional rotational cycle are part of an... redistribution of soil, rock, sand, or other surficial materials in a manner which changes any area of the waters..., grading, or other means to fill in wetland areas is not plowing. Rock crushing activities which result...

  18. 40 CFR 232.3 - Activities not requiring permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section. Activities on areas lying fallow as part of a conventional rotational cycle are part of an... redistribution of soil, rock, sand, or other surficial materials in a manner which changes any area of the waters..., grading, or other means to fill in wetland areas is not plowing. Rock crushing activities which result...

  19. 40 CFR 232.3 - Activities not requiring permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... section. Activities on areas lying fallow as part of a conventional rotational cycle are part of an... redistribution of soil, rock, sand, or other surficial materials in a manner which changes any area of the waters..., grading, or other means to fill in wetland areas is not plowing. Rock crushing activities which result...

  20. 40 CFR 232.3 - Activities not requiring permits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... section. Activities on areas lying fallow as part of a conventional rotational cycle are part of an... redistribution of soil, rock, sand, or other surficial materials in a manner which changes any area of the waters..., grading, or other means to fill in wetland areas is not plowing. Rock crushing activities which result...

  1. Multidisciplinary and Active/Collaborative Approaches in Teaching Requirements Engineering

    ERIC Educational Resources Information Center

    Rosca, Daniela

    2005-01-01

    The requirements engineering course is a core component of the curriculum for the Master's in Software Engineering programme, at Monmouth University (MU). It covers the process, methods and tools specific to this area, together with the corresponding software quality issues. The need to produce software engineers with strong teamwork and…

  2. El Universo a Sus Pies: Actividades y Recursos para Astronomia (Universe at Your Fingertips: An Astronomy Activity and Resource Notebook).

    ERIC Educational Resources Information Center

    Fraknoi, Andrew, Ed.; Schatz, Dennis, Ed.

    The goal of this resource notebook is to provide activities selected by astronomers and classroom teachers, comprehensive resource lists and bibliographies, background material on astronomical topics, and teaching ideas from experienced astronomy educators. Activities are grouped into several major areas of study in astronomy including lunar…

  3. 33 CFR 322.3 - Activities requiring permits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... States that are part of the civil works activities of the Corps of Engineers, unless covered by a... separate regulations. Agreement for construction or engineering services performed for other agencies...

  4. 33 CFR 322.3 - Activities requiring permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... States that are part of the civil works activities of the Corps of Engineers, unless covered by a... separate regulations. Agreement for construction or engineering services performed for other agencies...

  5. 33 CFR 322.3 - Activities requiring permits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... States that are part of the civil works activities of the Corps of Engineers, unless covered by a... separate regulations. Agreement for construction or engineering services performed for other agencies...

  6. NASA Propulsion Sub-System Concept Studies and Risk Reduction Activities for Resource Prospector Lander

    NASA Technical Reports Server (NTRS)

    Trinh, Huu P.

    2015-01-01

    NASA's exploration roadmap is focused on developing technologies and performing precursor missions to advance the state of the art for eventual human missions to Mars. One of the key components of this roadmap is various robotic missions to Near-Earth Objects, the Moon, and Mars to fill in some of the strategic knowledge gaps. The Resource Prospector (RP) project is one of these robotic precursor activities in the roadmap. RP is a multi-center and multi-institution project to investigate the polar regions of the Moon in search of volatiles. The mission is rated Class D and is approximately 10 days, assuming a five day direct Earth to Moon transfer. Because of the mission cost constraint, a trade study of the propulsion concepts was conducted with a focus on available low-cost hardware for reducing cost in development, while technical risk, system mass, and technology advancement requirements were also taken into consideration. The propulsion system for the lander is composed of a braking stage providing a high thrust to match the lander's velocity with the lunar surface and a lander stage performing the final lunar descent. For the braking stage, liquid oxygen (LOX) and liquid methane (LCH4) propulsion systems, derived from the Morpheus experimental lander, and storable bi-propellant systems, including the 4th stage Peacekeeper (PK) propulsion components and Space Shuttle orbital maneuvering engine (OME), and a solid motor were considered for the study. For the lander stage, the trade study included miniaturized Divert Attitude Control System (DACS) thrusters (Missile Defense Agency (MDA) heritage), their enhanced thruster versions, ISE-100 and ISE-5, and commercial-off-the-shelf (COTS) hardware. The lowest cost configuration of using the solid motor and the PK components while meeting the requirements was selected. The reference concept of the lander is shown in Figure 1. In the current reference configuration, the solid stage is the primary provider of delta

  7. Assessing the Influence of Human Activities on Global Water Resources Using an Advanced Land Surface Model

    NASA Astrophysics Data System (ADS)

    Pokhrel, Y.; Hanasaki, N.; Koirala, S.; Kanae, S.; Oki, T.

    2010-12-01

    In order to examine the impact of human intervention on the global hydrological cycle, a Land Surface Model was enhanced with schemes to assess the anthropogenic disturbance on the natural water flow at the global scale. Four different schemes namely; reservoir operation, crop growth, environmental flow, and anthropogenic water withdrawal modules from a state-of-the-art global water resources assessment model called H08 were integrated into an offline version of LSM, Minimal Advance Treatment of Surface Interaction and Runoff (MATSIRO). MATSIRO represents majority of the hydrological processes of water and energy exchange between the land surface and the atmosphere on a physical basis and is designed to be coupled with GCM. The integrated model presented here thus has the capability to simulate both natural and anthropogenic flows of water globally at a spatial resolution of 1°x1°, considering dam operation, domestic, industrial and agricultural water withdrawals and environmental flow requirements. The model can also be coupled with climate models to assess the impact of human activities on the climate system. A simple groundwater scheme was also incorporated and the model can be used to assess the change in water table due to groundwater pumping for irrigation. The model was validated by comparing simulated soil moisture, river discharge and Terrestrial Water Storage Anomaly (TWSA) with observations. The model performs well in simulating TWSA as compared to GRACE observation in different river basins ranging from very wet to very dry. Soil moisture cannot be validated globally because of the lack of validation datasets. For Illinois region, where long term soil moisture observations are available, the model captures the seasonal variation quite well. The simulated global potential irrigation demand is about 1100km3/year, which is within the range of previously published estimates based on various water balance models and LSMs. The model has an advanced option

  8. Summary. [California activities in remote sensing and management of water resources

    NASA Technical Reports Server (NTRS)

    Colwell, R. N.

    1973-01-01

    University of California activities in the development of remote sensing techniques and their application in the study of water resources within the state are summarized. It is pointed out that the summary is very lengthy due to fact that NASA had requested a dramatic reorientation of the study. For this reason it was felt that the co-investigators and other participants, need a rather detailed and systematic tabulation of the relevant facts that have been uncovered during the period since the reorientation.

  9. Implications of climatic seasonality on activity patterns and resource use by sympatric peccaries in northern Pantanal.

    PubMed

    Hofmann, Gabriel Selbach; Coelho, Igor Pfeifer; Bastazini, Vinicius Augusto Galvão; Cordeiro, José Luís Passos; de Oliveira, Luiz Flamarion Barbosa

    2016-03-01

    We evaluated the effects of climate seasonality from a thermal and water availability perspective on the activity patterns and resource use of Pecari tajacu and Tayassu pecari during wet and dry seasons in the northeastern Brazilian Pantanal. We used camera traps and temperature sensors to record species activity patterns in relation to temperature, established five habitat categories based on flooding intensity and local vegetation characteristics, assessed the activity patterns of each species in dry and wet periods and in artificial water bodies using circular statistical metrics, and calculated niche amplitude and overlap on three axes (temperature, time, and habitat) in both periods. Peccaries shared a strong resemblance in resource use and in their responses to seasonal variations in the tested gradients. The activity patterns of both species exhibited a significant correlation with air temperature on all the evaluated measures, and both species strongly reduced their activity when the air temperature exceeded 35 °C. High temperatures associated with low water availability were most likely responsible for the changes in species activity patterns, which resulted in an increased temporal overlap in habitat use throughout the dry season. However, the peccaries avoided intensively flooded habitats; therefore, the habitat gradient overlap was greater during the wet period. Our results show that an increase in niche overlap on the environmental gradient as a result of climatic seasonality may be partially compensated by a reduction in other niche dimensions. In this case, temporal partitioning appears to be an important, viable mechanism to reduce competition by potentially competing species.

  10. Water-resources activities of the U.S. Geological Survey

    USGS Publications Warehouse

    Appel, D. H.

    1990-01-01

    The U.S. Geological Survey (USGS) has been active in West Virginia since the early 1900's. During recent years, the District completed several investigations as well as initiated others. An intense effort has been made to publish interpretive reports and data on a near-current basis. As a result of this effort, a significant number of water resources reports were completed and/or published during the 1989 fiscal year. This report contains a complete list of USGS reports addressing West Virginia hydrology as of December 1989. The mission of the Water Resources Division is to provide the hydrologic information and understanding needed for the optimum utilization and management of the Nation 's water resources for the overall benefit of the people in the United States. This is accomplished, in large part , through cooperation with other Federal and non-Federal agencies, by: (1) Collecting, on a systematic basis, data needed for the continuing determination and evaluation of the quantity, quality, and use of the Nation 's water resources; (2) Conducting analytical and interpretive water resource appraisals describing the occurrence, availability, and the physical, chemical, and biological characteristics of surface and groundwater; (3) conducting supportive basic and problem-oriented research in hydraulics, hydrology, and related fields of science to improve the scientific basis for investigations and measurement techniques and to understand hydrologic systems sufficiently well to quantitatively predict their response to stress, either natural or manmade; (4) disseminating the water data and the results of these investigations and research through reports, maps, computerized information services, and other forms of public releases; (5) Coordinating the activities of Federal agencies in the acquisition of water data for streams, lakes, reservoirs, estuaries, and groundwaters; and (6) Providing scientific and technical assistance in hydrologic fields to other Federal

  11. Highly porous activated carbons from resource-recovered Leucaena leucocephala wood as capacitive deionization electrodes.

    PubMed

    Hou, Chia-Hung; Liu, Nei-Ling; Hsi, Hsing-Cheng

    2015-12-01

    Highly porous activated carbons were resource-recovered from Leucaena leucocephala (Lam.) de Wit. wood through combined chemical and physical activation (i.e., KOH etching followed by CO2 activation). This invasive species, which has severely damaged the ecological economics of Taiwan, was used as the precursor for producing high-quality carbonaceous electrodes for capacitive deionization (CDI). Carbonization and activation conditions strongly influenced the structure of chars and activated carbons. The total surface area and pore volume of activated carbons increased with increasing KOH/char ratio and activation time. Overgasification induced a substantial amount of mesopores in the activated carbons. In addition, the electrochemical properties and CDI electrosorptive performance of the activated carbons were evaluated; cyclic voltammetry and galvanostatic charge/discharge measurements revealed a typical capacitive behavior and electrical double layer formation, confirming ion electrosorption in the porous structure. The activated-carbon electrode, which possessed high surface area and both mesopores and micropores, exhibited improved capacitor characteristics and high electrosorptive performance. Highly porous activated carbons derived from waste L. leucocephala were demonstrated to be suitable CDI electrode materials.

  12. COPD symptom burden: impact on health care resource utilization, and work and activity impairment

    PubMed Central

    Ding, Bo; Small, Mark; Bergström, Gina; Holmgren, Ulf

    2017-01-01

    Background Chronic obstructive pulmonary disease (COPD) can greatly impact the quality of life by limiting patients’ activities. However, data on impact of symptomatic burden on the health care resource utilization (HCRU) and employment in COPD are lacking. We examined the association between COPD Assessment Test (CAT) score and direct/indirect costs associated with HCRU and work productivity. Methods Data from >2,100 patients with COPD consulting for routine care were derived from respiratory disease-specific programs in Europe, the USA and China. Questionnaires, including CAT and Work Productivity and Activity Impairment (WPAI), were used to collect the past and current disease status data and HCRU characteristics from physicians (general practitioners/specialists) and patients. A regression approach was used to quantify the association of CAT with HCRU and WPAI variables. CAT score was modeled as a continuous independent variable (range: 0–40). Results Ninety percent of patients with COPD had a CAT score ≥10. Short-acting therapy and maintenance bronchodilator monotherapy, respectively, were currently prescribed to patients with CAT scores of 10–19 (5.8% and 27.6%), 20–29 (5.1% and 13.1%) and 30–40 (2.8% and 6.6%). Prescribing of maintenance bronchodilator dual therapy was low across the CAT score groups (0–9, 7.8%; 10–19, 6.4%; 20–29, 5.9%; 30–40, 4.4%), whereas maintenance triple combination therapy was prescribed more commonly in patients with higher CAT scores (0–9, 16.1%; 10–19, 23.2%; 20–29, 25.9%; 30–40, 35.5%). Increasing CAT scores were significantly associated with a higher frequency of primary care physician visits (P<0.001), pulmonologist visits (P=0.007), exacerbations requiring hospitalization (P<0.001) and WPAI scores (P<0.001). Conclusion Most patients with COPD presented with high symptom levels, despite being treated for COPD. Increasing symptom burden was associated with increasing HCRU and had a detrimental impact

  13. Requirement of ERK activation for visual cortical plasticity.

    PubMed

    Di Cristo, G; Berardi, N; Cancedda, L; Pizzorusso, T; Putignano, E; Ratto, G M; Maffei, L

    2001-06-22

    Experience-dependent plasticity in the developing visual cortex depends on electrical activity and molecular signals involved in stabilization or removal of inputs. Extracellular signal-regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated by both factors. We show that two different inhibitors of the ERK pathway suppress the induction of two forms of long-term potentiation (LTP) in rat cortical slices and that their intracortical administration to monocularly deprived rats prevents the shift in ocular dominance towards the nondeprived eye. These results demonstrate that the ERK pathway is necessary for experience-dependent plasticity and for LTP of synaptic transmission in the developing visual cortex.

  14. Brain feminization requires active repression of masculinization via DNA methylation

    PubMed Central

    Nugent, Bridget M.; Wright, Christopher L.; Shetty, Amol C.; Hodes, Georgia E.; Lenz, Kathryn M.; Mahurkar, Anup; Russo, Scott J.; Devine, Scott E.; McCarthy, Margaret M.

    2015-01-01

    The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a perinatal sensitive period. It has been assumed that the undifferentiated brain is masculinized by direct induction of transcription by ligand-activated nuclear steroid receptors. We found that a primary effect of gonadal steroids in the highly sexually-dimorphic preoptic area (POA) is to reduce activity of DNA methyltransferase (Dnmt) enzymes, thereby decreasing DNA methylation and releasing masculinizing genes from epigenetic repression. Pharmacological inhibition of Dnmts mimicked gonadal steroids, resulting in masculinized neuronal markers and male sexual behavior in females. Conditional knockout of the de novo Dnmt isoform, Dnmt3a, also masculinized sexual behavior in female mice. RNA sequencing revealed gene and isoform variants modulated by methylation that may underlie the divergent reproductive behaviors of males versus females. Our data show that brain feminization is maintained by the active suppression of masculinization via DNA methylation. PMID:25821913

  15. 78 FR 12676 - Timing Requirements for the Submission of a Site Assessment Plan (SAP) or General Activities Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... calving grounds; barrier islands, beaches, dunes, and wetlands. (6) Archaeological resources As required..., rookeries, hard bottom habitat, chemosynthetic communities, and calving grounds; barrier islands,...

  16. Charge requirements of lipid II flippase activity in Escherichia coli.

    PubMed

    Butler, Emily K; Tan, Wee Boon; Joseph, Hildy; Ruiz, Natividad

    2014-12-01

    Peptidoglycan (PG) is an extracytoplasmic glycopeptide matrix essential for the integrity of the envelope of most bacteria. The PG building block is a disaccharide-pentapeptide that is synthesized as a lipid-linked precursor called lipid II. The translocation of the amphipathic lipid II across the cytoplasmic membrane is required for subsequent incorporation of the disaccharide-pentapeptide into PG. In Escherichia coli, the essential inner membrane protein MurJ is the lipid II flippase. Previous studies showed that 8 charged residues in the central cavity region of MurJ are crucial for function. Here, we completed the functional analysis of all 57 charged residues in MurJ and demonstrated that the respective positive or negative charge of the 8 aforementioned residues is required for proper MurJ function. Loss of the negative charge in one of these residues, D39, causes a severe defect in MurJ biogenesis; by engineering an intragenic suppressor mutation that restores MurJ biogenesis, we found that this charge is also essential for MurJ function. Because of the low level of homology between MurJ and putative orthologs from Gram-positive bacteria, we explored the conservation of these 8 charged residues in YtgP, a homolog from Streptococcus pyogenes. We found that only 3 positive charges are similarly positioned and essential in YtgP; YtgP possesses additional charged residues within its predicted cavity that are essential for function and conserved among Gram-positive bacteria. From these data, we hypothesize that some charged residues in the cavity region of MurJ homologs are required for interaction with lipid II and/or energy coupling during transport.

  17. BioUSeR: a semantic-based tool for retrieving Life Science web resources driven by text-rich user requirements

    PubMed Central

    2013-01-01

    Background Open metadata registries are a fundamental tool for researchers in the Life Sciences trying to locate resources. While most current registries assume that resources are annotated with well-structured metadata, evidence shows that most of the resource annotations simply consists of informal free text. This reality must be taken into account in order to develop effective techniques for resource discovery in Life Sciences. Results BioUSeR is a semantic-based tool aimed at retrieving Life Sciences resources described in free text. The retrieval process is driven by the user requirements, which consist of a target task and a set of facets of interest, both expressed in free text. BioUSeR is able to effectively exploit the available textual descriptions to find relevant resources by using semantic-aware techniques. Conclusions BioUSeR overcomes the limitations of the current registries thanks to: (i) rich specification of user information needs, (ii) use of semantics to manage textual descriptions, (iii) retrieval and ranking of resources based on user requirements. PMID:23635042

  18. Minimum Energy Requirements for Sustained Microbial Activity in Anoxic Sediments

    NASA Technical Reports Server (NTRS)

    Hoehler, Tori M.; Alperin, Marc J.; Albert, Daniel B.; Martens, Christoper S.; DeVincenzi, Donald L. (Technical Monitor)

    2000-01-01

    Currently understood mechanisms of biochemical energy conservation dictate that, in order to be biologically useful, energy must be available to organisms in "quanta" equal to, at minimum one-third to one-fifth of the energy required to synthesize ATP in vivo. The existence of this biological energy quantum means that a significant fraction of the chemical amp on Earth cannot be used to drive biological productivity, and places a fundamental thermodynamic constraint on the origins, evolution, and distribution of life. We examined the energy requirements of intact microbial assemblages in anoxic sediments from Cape Lookout Bight, NC, USA, using dissolved hydrogen concentrations as a non-invasive probe. In this system, the thermodynamics of metabolic processes occurring inside microbial cells is reflected quantitatively by H2 concentrations measured outside those cells. We find that methanogenic archaea are supported by energy yields as small as 10 kJ per mol, about half the quantity calculated from studies of microorganisms in culture. This finding implies that a significantly broader range of geologic and chemical niches might be exploited by microorganisms than would otherwise be expected.

  19. Tapered whiskers are required for active tactile sensation

    PubMed Central

    Hires, Samuel Andrew; Pammer, Lorenz; Svoboda, Karel; Golomb, David

    2013-01-01

    Many mammals forage and burrow in dark constrained spaces. Touch through facial whiskers is important during these activities, but the close quarters makes whisker deployment challenging. The diverse shapes of facial whiskers reflect distinct ecological niches. Rodent whiskers are conical, often with a remarkably linear taper. Here we use theoretical and experimental methods to analyze interactions of mouse whiskers with objects. When pushed into objects, conical whiskers suddenly slip at a critical angle. In contrast, cylindrical whiskers do not slip for biologically plausible movements. Conical whiskers sweep across objects and textures in characteristic sequences of brief sticks and slips, which provide information about the tactile world. In contrast, cylindrical whiskers stick and remain stuck, even when sweeping across fine textures. Thus the conical whisker structure is adaptive for sensor mobility in constrained environments and in feature extraction during active haptic exploration of objects and surfaces. DOI: http://dx.doi.org/10.7554/eLife.01350.001 PMID:24252879

  20. Fast Delayed Rectifier Potassium Current Required for Circadian Neural Activity

    PubMed Central

    JN, Itri; S, Michel; MJ, Vansteensel; JH, Meijer; CS, Colwell

    2005-01-01

    In mammals, the precise circadian timing of many biological processes depends on the generation of oscillations in neural activity of pacemaker cells in the suprachiasmatic nucleus (SCN). The ionic mechanisms underlying these rhythms are largely unknown. Using the mouse brain slice preparation, we demonstrate that the magnitude of fast delayed rectifier potassium currents exhibits a diurnal rhythm that peaks during the day. Importantly, this rhythm continues in constant darkness, providing the first demonstration of the circadian regulation of an intrinsic voltage–gated current in mammalian cells. Blocking this current prevented the daily rhythm in firing rate in SCN neurons. Kv3.1b and Kv3.2 potassium channels were found to be widely distributed within the SCN with higher expression during the day. We conclude that the fast delayed rectifier is necessary for the circadian modulation of electrical activity in SCN neurons, and represents an important part of the ionic basis for the generation of rhythmic output. PMID:15852012

  1. Cullin E3 Ligase Activity Is Required for Myoblast Differentiation.

    PubMed

    Blondelle, Jordan; Shapiro, Paige; Domenighetti, Andrea A; Lange, Stephan

    2017-04-07

    The role of cullin E3-ubiquitin ligases for muscle homeostasis is best known during muscle atrophy, as the cullin-1 substrate adaptor atrogin-1 is among the most well-characterized muscle atrogins. We investigated whether cullin activity was also crucial during terminal myoblast differentiation and aggregation of acetylcholine receptors for the establishment of neuromuscular junctions in vitro. The activity of cullin E3-ligases is modulated through post-translational modification with the small ubiquitin-like modifier nedd8. Using either the Nae1 inhibitor MLN4924 (Pevonedistat) or siRNA against nedd8 in early or late stages of differentiation on C2C12 myoblasts, and primary satellite cells from mouse and human, we show that cullin E3-ligase activity is necessary for each step of the muscle cell differentiation program in vitro. We further investigate known transcriptional repressors for terminal muscle differentiation, namely ZBTB38, Bhlhe41, and Id1. Due to their identified roles for terminal muscle differentiation, we hypothesize that the accumulation of these potential cullin E3-ligase substrates may be partially responsible for the observed phenotype. MLN4924 is currently undergoing clinical trials in cancer patients, and our experiments highlight concerns on the homeostasis and regenerative capacity of muscles in these patients who often experience cachexia.

  2. Local arginase 1 activity is required for cutaneous wound healing.

    PubMed

    Campbell, Laura; Saville, Charis R; Murray, Peter J; Cruickshank, Sheena M; Hardman, Matthew J

    2013-10-01

    Chronic nonhealing wounds in the elderly population are associated with a prolonged and excessive inflammatory response, which is widely hypothesized to impede healing. Previous studies have linked alterations in local L-arginine metabolism, principally mediated by the enzymes arginase (Arg) and inducible nitric oxide synthase (iNOS), to pathological wound healing. Over subsequent years, interest in Arg/iNOS has focused on the classical versus alternatively activated (M1/M2) macrophage paradigm. Although the role of iNOS during healing has been studied, Arg contribution to healing remains unclear. Here, we report that Arg is dynamically regulated during acute wound healing. Pharmacological inhibition of local Arg activity directly perturbed healing, as did Tie2-cre-mediated deletion of Arg1, revealing the importance of Arg1 during healing. Inhibition or depletion of Arg did not alter alternatively activated macrophage numbers but instead was associated with increased inflammation, including increased influx of iNOS(+) cells and defects in matrix deposition. Finally, we reveal that in preclinical murine models reduced Arg expression directly correlates with delayed healing, and as such may represent an important future therapeutic target.

  3. Availability of physical activity resources in the environment for adults with intellectual disabilities

    PubMed Central

    Howie, Erin K.; Barnes, Timothy L.; McDermott, Suzanne; Mann, Joshua R.; Clarkson, John; Meriwether, Rebecca A.

    2011-01-01

    Background Adults with intellectual disabilities (ID) have high rates of physical inactivity, yet little is known about the prevalence of facilitators and barriers in the built environment contributing to these high rates. Objective To describe the physical activity resources available to adults with ID in both the home and day programs outside of the home. Methods Demographic information was collected on a sample of adults with ID. A survey checklist of the physical activity environment at the participants’ home and the facility or workplace where the participant spent his/her weekdays was collected by trained research staff. Differences in the prevalence of environmental resources between those living in group homes and those living alone or with family were tested using χ2 tests. Results A total of 103 participants had complete demographic and environmental data. Of these, only 37.9% had exercise equipment available, 39.8% had sports equipment, and 15.5% had a bicycle in the home environment. At the facility where the individual attended a day program or where the individual was employed, 55.4 had sports equipment, 50.5% had an outdoor recreation area, 41.8% had an indoor recreation area, and 41.8 had organized physical activities. Those who lived in group homes were more likely to have access to basketball hoops, sports fields, and recreation centers than those who lived alone or with family (p < .01). Conclusions Adults with ID have few physical activity environmental resources and opportunities available to them, especially those not living in group homes. Future interventions are needed to increase physical activity opportunities in this underserved population. PMID:22226297

  4. Water Resources Research October 1, 1979 - September 30, 1980: Summary statements of research activities by the Water Resources Division

    USGS Publications Warehouse

    ,

    1981-01-01

    Research in the WRD had its beginnings in the late 1950's when the "core research" line item was added to the Congressional budget. Since this time the Federal program has grown from a "basic sciences" program to one that includes a broad spectrum of basic and applied scientific investigations. Water resources research in WRD includes the study of water in all its phases and uses the basic sciences of mathematics, chemistry, physics, biology, geology and engineering to gain a fundamental understanding of the processes that affect the movement of water and its chemical constituents through hydrologic systems. The basic knowledge and methodologies derived from water resources research are applicable not only to the solution of current problems associated with the Nation's water resources, but also to anticipated hydrologic issues.

  5. TERSSE: Definition of the Total Earth Resources System for the Shuttle Era. Volume 8: User's Mission and System Requirements Data (appendix A of Volume 3)

    NASA Technical Reports Server (NTRS)

    1974-01-01

    A computer printout is presented of the mission requirement for the TERSSE missions and their associated user tasks. The data included in the data base represents a broad-based attempt to define the amount, extent, and type of information needed for an earth resources management program in the era of the space shuttle. An effort was made to consider all aspects of remote sensing and resource management; because of its broad scope, it is not intended that the data be used without verification for in-depth studies of particular missions and/or users. The data base represents the quantitative structure necessary to define the TERSSE architecture and requirements, and to an overall integrated view of the earth resources technology requirements of the 1980's.

  6. P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface.

    PubMed

    Loo, Tip W; Clarke, David M

    2016-04-01

    P-glycoprotein (P-gp) is an ABC (ATP-Binding Cassette) drug pump. A common feature of ABC proteins is that they are organized into two wings. Each wing contains a transmembrane domain (TMD) and a nucleotide-binding domain (NBD). Drug substrates and ATP bind at the interface between the TMDs and NBDs, respectively. Drug transport involves ATP-dependent conformational changes between inward- (open, NBDs far apart) and outward-facing (closed, NBDs close together) conformations. P-gps crystallized in the presence of detergent show an open structure. Human P-gp is inactive in detergent but basal ATPase activity is restored upon addition of lipids. The lipids might cause closure of the wings to bring the NBDs close together to allow ATP hydrolysis. We show however, that cross-linking the wings together did not activate ATPase activity when lipids were absent suggesting that lipids may induce other structural changes required for ATPase activity. We then tested the effect of lipids on disulfide cross-linking of mutants at the first transmission interface between intracellular loop 4 (TMD2) and NBD1. Mutants L443C/S909C and L443C/R905C but not G471C/S909C and V472C/S909C were cross-linked with oxidant when in membranes. The mutants were then purified and cross-linked with or without lipids. Mutants G471C/S909C and V472C/S909C cross-linked only in the absence of lipids whereas mutants L443C/S909C and L443C/R905C were cross-linked only in the presence of lipids. The results suggest that lipids activate a switch at the first transmission interface and that the structure of P-gp is different in detergents and lipids.

  7. United States data collection activities and requirements, volume 1

    NASA Technical Reports Server (NTRS)

    Hrin, S.; Mcgregor, D.

    1977-01-01

    The potential market for a data collection system was investigated to determine whether the user needs would be sufficient to support a satellite relay data collection system design. The activities of 107,407 data collections stations were studied to determine user needs in agriculture, climatology, environmental monitoring, forestry, geology, hydrology, meteorology, and oceanography. Descriptions of 50 distinct data collections networks are described and used to form the user data base. The computer program used to analyze the station data base is discussed, and results of the analysis are presented in maps and graphs. Information format and coding is described in the appendix.

  8. Converging on the optimal attainment of requirements

    NASA Technical Reports Server (NTRS)

    Feather, M. S.; Menzies, T.

    2002-01-01

    Planning for the optimal attainment of requirements is an important early lifecycle activity. However, such planning is difficult when dealing with competing requirements, limited resources, and the incompleteness of information available at requirements time.

  9. Slicing-independent RISC activation requires the argonaute PAZ domain.

    PubMed

    Gu, Shuo; Jin, Lan; Huang, Yong; Zhang, Feijie; Kay, Mark A

    2012-08-21

    Small RNAs regulate genetic networks through a ribonucleoprotein complex called the RNA-induced silencing complex (RISC), which, in mammals, contains at its center one of four Argonaute proteins (Ago1-Ago4). A key regulatory event in the RNA interference (RNAi) and microRNA (miRNA) pathways is Ago loading, wherein double-stranded small-RNA duplexes are incorporated into RISC (pre-RISC) and then become single-stranded (mature RISC), a process that is not well understood. The Agos contain an evolutionarily conserved PAZ (Piwi/Argonaute/Zwille) domain whose primary function is to bind the 3' end of small RNAs. We created multiple PAZ-domain-disrupted mutant Ago proteins and studied their biochemical properties and biological functionality in cells. We found that the PAZ domain is dispensable for Ago loading of slicing-competent RISC. In contrast, in the absence of slicer activity or slicer-substrate duplex RNAs, PAZ-disrupted Agos bound duplex small interfering RNAs, but were unable to unwind or eject the passenger strand and form functional RISC complexes. We have discovered that the highly conserved PAZ domain plays an important role in RISC activation, providing new mechanistic insights into how miRNAs regulate genes, as well as new insights for future design of miRNA- and RNAi-based therapeutics.

  10. PARP-1 activation requires local unfolding of an autoinhibitory domain

    PubMed Central

    Dawicki-McKenna, Jennine M.; Langelier, Marie-France; DeNizio, Jamie E.; Riccio, Amanda A.; Cao, Connie D.; Karch, Kelly R.; McCauley, Michael; Steffen, Jamin D.; Black, Ben E.; Pascal, John M.

    2015-01-01

    SUMMARY Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks sharply elevate PARP-1 catalytic activity to mount a cell survival repair response, whereas persistent PARP-1 hyperactivation during severe genotoxic stress is associated with cell death. The mechanism for tight control of the robust catalytic potential of PARP-1 remains unclear. By monitoring PARP-1 dynamics using hydrogen/deuterium exchange-mass spectrometry (HXMS), we unexpectedly find that a specific portion of the helical subdomain (HD) of the catalytic domain rapidly unfolds when PARP-1 encounters a DNA break. Together with biochemical and crystallographic analysis of HD deletion mutants, we show that the HD is an autoinhibitory domain that blocks productive NAD+ binding. Our molecular model explains how PARP-1 DNA damage detection leads to local unfolding of the HD that relieves autoinhibition, and has important implications for the design of PARP inhibitors. PMID:26626480

  11. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.

    PubMed

    Dawicki-McKenna, Jennine M; Langelier, Marie-France; DeNizio, Jamie E; Riccio, Amanda A; Cao, Connie D; Karch, Kelly R; McCauley, Michael; Steffen, Jamin D; Black, Ben E; Pascal, John M

    2015-12-03

    Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD(+) to regulate multiple cellular processes. DNA breaks sharply elevate PARP-1 catalytic activity to mount a cell survival repair response, whereas persistent PARP-1 hyperactivation during severe genotoxic stress is associated with cell death. The mechanism for tight control of the robust catalytic potential of PARP-1 remains unclear. By monitoring PARP-1 dynamics using hydrogen/deuterium exchange-mass spectrometry (HXMS), we unexpectedly find that a specific portion of the helical subdomain (HD) of the catalytic domain rapidly unfolds when PARP-1 encounters a DNA break. Together with biochemical and crystallographic analysis of HD deletion mutants, we show that the HD is an autoinhibitory domain that blocks productive NAD(+) binding. Our molecular model explains how PARP-1 DNA damage detection leads to local unfolding of the HD that relieves autoinhibition, and has important implications for the design of PARP inhibitors.

  12. Gearbox design for uncertain load requirements using active robust optimization

    NASA Astrophysics Data System (ADS)

    Salomon, Shaul; Avigad, Gideon; Purshouse, Robin C.; Fleming, Peter J.

    2016-04-01

    Design and optimization of gear transmissions have been intensively studied, but surprisingly the robustness of the resulting optimal design to uncertain loads has never been considered. Active Robust (AR) optimization is a methodology to design products that attain robustness to uncertain or changing environmental conditions through adaptation. In this study the AR methodology is utilized to optimize the number of transmissions, as well as their gearing ratios, for an uncertain load demand. The problem is formulated as a bi-objective optimization problem where the objectives are to satisfy the load demand in the most energy efficient manner and to minimize production cost. The results show that this approach can find a set of robust designs, revealing a trade-off between energy efficiency and production cost. This can serve as a useful decision-making tool for the gearbox design process, as well as for other applications.

  13. A preliminary study of the microbial resources and their biological activities of the East china sea.

    PubMed

    Lu, Xiaoling; Liu, Xiaoyu; Long, Cong; Wang, Guoxiang; Gao, Yun; Liu, Junhua; Jiao, Binghua

    2011-01-01

    East China Sea is one of the four sea areas in China, which possesses peculiar ecological environment and many kinds of living creatures, especially the microorganisms. We established the East China Sea microorganism library (during 2006-2010) for the first time, which stored about 30000 strains that covered most kinds of the species. In this paper, 395 pure strains of East China Sea microorganism library which belong to 33 different genera were mainly introduced. Sulfitobacter, Halomonas, Bacillus, Pseudoalteromonas, and Idiomarina were the most dominant species. On the large-scale biological activity screening of the 395 strains, 100 strains possess different biological activities based on different screening models, of which 11.4% strains have antibacterial activities, 15.9% have cytotoxicity activities, and 6.1% have antioxidation activities. Besides, the secondary metabolites of 6 strains with strong biological activities were studied systematically; diketopiperazines and macrocyclic lactones are the active secondary metabolites. The species and the biological activity of microorganisms diversity, the abundant structure type of the secondary metabolites, and their bioactivities all indicate that East China Sea is a potent marine microorganisms-derived developing resource for drug discovery.

  14. Earth Resources

    ERIC Educational Resources Information Center

    Brewer, Tom

    1970-01-01

    Reviews some of the more concerted, large-scale efforts in the earth resources areas" in order to help the computer community obtain insights into the activities it can jointly particpate in withthe earth resources community." (Author)

  15. 30 CFR 783.11 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... UNDERGROUND MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 783... impacted by the proposed underground mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  16. 30 CFR 783.11 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... UNDERGROUND MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 783... impacted by the proposed underground mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  17. 30 CFR 783.11 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... UNDERGROUND MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 783... impacted by the proposed underground mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  18. 30 CFR 779.11 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 779... impacted by the proposed surface mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  19. 30 CFR 779.11 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 779... impacted by the proposed surface mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  20. 30 CFR 779.11 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 779... impacted by the proposed surface mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  1. 30 CFR 779.11 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 779... impacted by the proposed surface mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  2. 30 CFR 783.11 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... UNDERGROUND MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 783... impacted by the proposed underground mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  3. 30 CFR 783.11 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... UNDERGROUND MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 783... impacted by the proposed underground mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  4. 30 CFR 779.11 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR INFORMATION ON ENVIRONMENTAL RESOURCES § 779... impacted by the proposed surface mining activities. ... Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR...

  5. Activated Sludge. Selected Instructional Activities and References. Instructional Resources Monograph Series.

    ERIC Educational Resources Information Center

    Shepard, Clinton L.; Walasek, James B.

    This monograph contains a variety of selected materials related to wastewater treatment and water quality education and instruction. Part I presents a brief discussion of the activated sludge process in wastewater treatment operations. Part II, Instructional Units, contains selected portions of existing programs which may be utilized in…

  6. Activation of STING requires palmitoylation at the Golgi

    PubMed Central

    Mukai, Kojiro; Konno, Hiroyasu; Akiba, Tatsuya; Uemura, Takefumi; Waguri, Satoshi; Kobayashi, Toshihide; Barber, Glen N.; Arai, Hiroyuki; Taguchi, Tomohiko

    2016-01-01

    Stimulator of interferon genes (STING) is essential for the type I interferon response against DNA pathogens. In response to the presence of DNA and/or cyclic dinucleotides, STING translocates from the endoplasmic reticulum to perinuclear compartments. However, the role of this subcellular translocation remains poorly defined. Here we show that palmitoylation of STING at the Golgi is essential for activation of STING. Treatment with palmitoylation inhibitor 2-bromopalmitate (2-BP) suppresses palmitoylation of STING and abolishes the type I interferon response. Mutation of two membrane-proximal Cys residues (Cys88/91) suppresses palmitoylation, and this STING mutant cannot induce STING-dependent host defense genes. STING variants that constitutively induce the type I interferon response were found in patients with autoimmune diseases. The response elicited by these STING variants is effectively inhibited by 2-BP or an introduction of Cys88/91Ser mutation. Our results may lead to new treatments for cytosolic DNA-triggered autoinflammatory diseases. PMID:27324217

  7. User Requirements for the Application of Remote Sensing in the Planning and Management of Water Resource Systems

    NASA Technical Reports Server (NTRS)

    Burgy, R. H.

    1972-01-01

    Data relating to hydrologic and water resource systems and subsystems management are reported. Systems models, user application, and remote sensing technology are covered. Parameters governing water resources include evaportranspiration, vegetation, precipitation, streams and estuaries, reservoirs and lakes, and unsaturate and saturated soil zones.

  8. Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources.

    PubMed

    Zalli, Argita; Carvalho, Livia A; Lin, Jue; Hamer, Mark; Erusalimsky, Jorge D; Blackburn, Elizabeth H; Steptoe, Andrew

    2014-03-25

    Recent work has linked psychological stress with premature cellular aging as indexed by reduced leukocyte telomere length. The combination of shorter telomeres with high telomerase activity (TA) may be indicative of active cell stress. We hypothesized that older individuals characterized by shorter telomeres with high TA in unstimulated leukocytes would show signs of high allostatic load and low levels of protective psychosocial resources. We studied 333 healthy men and women aged 54-76 y who underwent laboratory testing in which we measured cardiovascular, neuroendocrine, and inflammatory responses to standardized mental stress tasks. The tasks elicited prompt increases in blood pressure (BP), heart rate, cortisol, and mediators of inflammation and reductions in heart rate variability, returning toward baseline levels following stress. However, men having shorter telomeres with high TA showed blunted poststress recovery in systolic BP, heart rate variability, and monocyte chemoattractant protein-1, together with reduced responsivity in diastolic BP, heart rate, and cortisol, in comparison to men with longer telomeres or men with shorter telomeres and low TA. Shorter telomeres with high TA were also associated with reduced social support, lower optimism, higher hostility, and greater early life adversity. These effects were independent of age, socioeconomic status, and body mass index. We did not observe differences among older women. Our findings suggest that active cell stress is associated with impaired physiological stress responses and impoverished psychosocial resources, reflecting an integration of cellular, systemic, and psychological stress processes potentially relevant to health in older men.

  9. Annual report on the U.S. Department of Energy`s cultural resource activities at Colorado UMTRA Project sites for October 1995--September 1996

    SciTech Connect

    1996-09-01

    This report summarizes the results of cultural resource activities conducted by the U.S. Department of Energy (DOE) at Uranium Mill Tailings Remedial Action (UMTRA) Project sites in Colorado for the period of October 1, 1995 through September 30, 1996. The inactive uranium mill tailings sites in Colorado are at Durango, Grand Junction, Gunnison, Maybell, Naturita, Rifle, and Slick Rock. On December 6, 1984, the DOE, the Advisory Council on Historic Preservation, and the Colorado State Historic Preservation Officer (SHPO) entered into a programmatic memorandum of understanding (PMOU). This PMOU requires the DOE to fulfillment of its obligations under various state and federal regulations for the protection and preservation of cultural resources. This report provides the state of Colorado with an annual report on the cultural resource activities performed for all UMTRA Project sites in Colorado. Due to the completion of surface activities at the UMTRA Project sites, this will be the last annual report to the state of Colorado. Cultural resources activities subsequent to this report will be reported to the state through site-specific correspondence.

  10. Regulation of Fuel and Fuel Additives: Refiner and Importer Quality Assurance Requirements for Downstream Oxygenate Blending and Requirements for Disposition of Pipeline Interfaces Additional Resources

    EPA Pesticide Factsheets

    EPA has published a Direct Final Rule that addresses requirements for parties that handle pipeline interface as well as addresses downstream quality assurance requirements for refiners (EPA publication # EPA-420-F-06-039).

  11. Design of Training Systems Utility Assessment: The Training Process Flow and System Capabilities/Requirements and Resources Models Operating in the TRAPAC Environment.

    ERIC Educational Resources Information Center

    Duffy, Larry R.

    The report summarizes the results of a field test conducted for the purpose of determining the utility to Naval training of the Systems Capabilities/Requirements and Resources (SCRR) and the Training Process Flow (TPF) computer-based mathematical models. Basic descriptions of the SCRR and the TPF and their development are given. Training…

  12. 20 CFR 404.1311 - Ninety-day active service requirement for World War II veterans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... World War II veterans. 404.1311 Section 404.1311 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Uniformed Services World War II Veterans § 404.1311 Ninety-day active service requirement for World War II veterans. (a) The 90 days of active service required for World War II veterans do not have to...

  13. 40 CFR 35.3540 - Requirements for funding set-aside activities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Requirements for funding set-aside... Requirements for funding set-aside activities. (a) General. If a State makes a grant or enters into a cooperative agreement with an assistance recipient to conduct set-aside activities, the recipient must...

  14. 40 CFR 35.3540 - Requirements for funding set-aside activities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Requirements for funding set-aside... Requirements for funding set-aside activities. (a) General. If a State makes a grant or enters into a cooperative agreement with an assistance recipient to conduct set-aside activities, the recipient must...

  15. 21 CFR 201.316 - Drugs with thyroid hormone activity for human use; required warning.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Drugs with thyroid hormone activity for human use... AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.316 Drugs with thyroid hormone activity for human use; required warning. (a)...

  16. 21 CFR 201.316 - Drugs with thyroid hormone activity for human use; required warning.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drugs with thyroid hormone activity for human use... AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.316 Drugs with thyroid hormone activity for human use; required warning. (a)...

  17. 20 CFR 404.1311 - Ninety-day active service requirement for World War II veterans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... World War II veterans. 404.1311 Section 404.1311 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Uniformed Services World War II Veterans § 404.1311 Ninety-day active service requirement for World War II veterans. (a) The 90 days of active service required for World War II veterans do not have to...

  18. 20 CFR 404.1311 - Ninety-day active service requirement for World War II veterans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... World War II veterans. 404.1311 Section 404.1311 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Uniformed Services World War II Veterans § 404.1311 Ninety-day active service requirement for World War II veterans. (a) The 90 days of active service required for World War II veterans do not have to...

  19. 20 CFR 404.1311 - Ninety-day active service requirement for World War II veterans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... World War II veterans. 404.1311 Section 404.1311 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Uniformed Services World War II Veterans § 404.1311 Ninety-day active service requirement for World War II veterans. (a) The 90 days of active service required for World War II veterans do not have to...

  20. 20 CFR 404.1311 - Ninety-day active service requirement for World War II veterans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... World War II veterans. 404.1311 Section 404.1311 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Uniformed Services World War II Veterans § 404.1311 Ninety-day active service requirement for World War II veterans. (a) The 90 days of active service required for World War II veterans do not have to...

  1. 77 FR 33479 - Information Collection Activities: Oil-Spill Response Requirements for Facilities Located Seaward...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... Bureau of Safety and Environmental Enforcement Information Collection Activities: Oil-Spill Response... requirements in the regulations under Part 254, ``Oil-Spill Response Requirements for Facilities Located... 254, Oil-Spill Response Requirements for Facilities Located Seaward of the Coast Line. OMB...

  2. Design requirements document for project W-520, immobilized low-activity waste disposal

    SciTech Connect

    Ashworth, S.C.

    1998-08-06

    This design requirements document (DRD) identifies the functions that must be performed to accept, handle, and dispose of the immobilized low-activity waste (ILAW) produced by the Tank Waste Remediation System (TWRS) private treatment contractors and close the facility. It identifies the requirements that are associated with those functions and that must be met. The functional and performance requirements in this document provide the basis for the conceptual design of the Tank Waste Remediation System Immobilized Low-Activity Waste disposal facility project (W-520) and provides traceability from the program-level requirements to the project design activity.

  3. Bat mortality and activity at a Northern Iowa wind resource area

    USGS Publications Warehouse

    Jain, A.A.; Koford, Rolf R.; Hancock, A.W.; Zenner, G.G.

    2011-01-01

    We examined bat collision mortality, activity and species composition at an 89-turbine wind resource area in farmland of north-central Iowa from mid-Apr. to mid-Dec., 2003 and mid-Mar. to mid-Dec., 2004. We found 30 bats beneath turbines on cleared ground and gravel access areas in 2003 and 45 bats in 2004. After adjusting for search probability, search efficiency and scavenging rate, we estimated total bat mortality at 396 ?? 72 (95 ci) in 2003 and 636 ?? 112 (95 ci) in 2004. Although carcasses were mostly migratory tree bats, we found a considerable proportion of little brown bats (Myotis lucifugus). We recorded 1465 bat echolocation call files at turbine sites ( 34.88 call files/detector-night) and 1536 bat call files at adjacent non-turbine sites ( 36.57 call files/detector-night). Bat activity did not differ significantly between turbine and non-turbine sites. A large proportion of recorded call files were made by Myotis sp. but this may be because we detected activity at ground level only. There was no relationship between types of turbine lights and either collision mortality or echolocation activity. The highest levels of bat echolocation activity and collision mortality were recorded during Jul. and Aug. during the autumn dispersal and migration period. The fatality rates for bats in general and little brown bats in particular were higher at the Top of Iowa Wind Resource Area than at other, comparable studies in the region. Future efforts to study behavior of bats in flight around turbines as well as cumulative impact studies should not ignore non-tree dwelling bats, generally regarded as minimally affected. ?? 2011, American Midland Naturalist.

  4. Health researchers' ancillary care obligations in low-resource settings: how can we tell what is morally required?

    PubMed

    Merritt, Maria W

    2011-12-01

    Health researchers working in low-resource settings often encounter serious unmet health needs among participants. What is the nature and extent of researchers' obligations to respond to such needs? Competing accounts have been proposed, but there is no independent standard by which to assess them or to guide future inquiry. I propose an independent standard and demonstrate its use. In conclusion I recommend two areas of focus for future inquiry: what makes an account of researchers' obligations reasonable from the standpoint of both participants and researchers and how general duties of rescue apply to researchers' resource-allocation decision making in low-resource settings.

  5. 1PM TODAY: EPA to Hold Media Conference Call on Study of Hydraulic Fracturing Activities on Drinking Water Resources

    EPA Pesticide Factsheets

    WASHINGTON - Environmental Protection Agency (EPA) officials will deliver remarks about the agency's study on potential impacts on drinking water resources in the United States from hydraulic fracturing activities, as requested by Congress, on a med

  6. Water Resources Division in the 1980's : a summary of activities and programs of the U.S. Geological Survey's Water Resources Division

    USGS Publications Warehouse

    Chase, Edith B.; Moore, John E.; Rickert, David A.

    1985-01-01

    The Water Resources Division of the U.S. Geological Survey has the principal responsibility within the Federal government for providing hydrologic information and appraising the Nation's water resounds. The Geological Survey is unique among government organizations because it has neither regulatory nor developmental authority--its sole product is information that is made available equally to all interested parties. This report describes the Water Resources Division's mission, organization, source of funds, and major programs. Three types of programs are described: long-term programs, which include the Federal-State cooperative program, coordination of Federal water-data acquisition, assistance to other Federal agencies, the national research program, the national water-data exchange, the water resources scientific information center, the national water-use information program, hydrologic-data collection, and international hydrology activities; topical programs, which include hazardous waste hydrology, coal and oil-shale hydrology, regional aquifer system analyses, acid rain, volcano hazards, and national water-resources conditions; and technical-assistance programs. Emphasis is on programs that will contribute to identifying, mitigating, or solving nationwide water-resources problems in the 1980's. A discussion of how the data and information axe disseminated and a selected list of references complete the report.

  7. Requirements for PKC-augmented JNK activation by MKK4/7

    PubMed Central

    Lopez-Bergami, Pablo; Ronai, Ze'ev

    2008-01-01

    The c-Jun N-terminal kinases (JNKs) are activated in response to stress, DNA damage, and cytokines by MKK4 and MKK7. We recently demonstrated that PKC can augment the degree of JNK activation by phosphorylating JNK, which requires the adaptor protein RACK1. Here we report on the conditions required for PKC-dependent JNK activation. In vitro kinase assays reveal that PKC phosphorylation of JNK is not sufficient for its activation but rather augments JNK activation by canonical JNK upstream kinases MKK4 or MKK7 alone or in combination. Further, to enhance JNK activity, PKC phosphorylation of JNK should precede its phosphorylation by MKK4/7. Inhibition of PKC phosphorylation of JNK affects both early and late phases of JNK activation following UV-irradiation and reduces the apoptotic response mediated by JNK. These data provide important insight into the requirements for PKC activation of JNK signaling. PMID:18182317

  8. Association between Natural Resources for Outdoor Activities and Physical Inactivity: Results from the Contiguous United States

    PubMed Central

    Jiang, Yan; Yuan, Yongping; Neale, Anne; Jackson, Laura; Mehaffey, Megan

    2016-01-01

    Protected areas including national/state parks and recreational waters are excellent natural resources that promote physical activity and interaction with Nature, which can relieve stress and reduce disease risk. Despite their importance, however, their contribution to human health has not been properly quantified. This paper seeks to evaluate quantitatively how national/state parks and recreational waters are associated with human health and well-being, taking into account of the spatial dependence of environmental variables for the contiguous U.S., at the county level. First, we describe available natural resources for outdoor activities (ANROA), using national databases that include features from the Protected Areas Database, NAVSTREETS, and ATTAINSGEO 305(b) Waters. We then use spatial regression techniques to explore the association of ANROA and socioeconomic status factors on physical inactivity rates. Finally, we use variance analysis to analyze ANROA’s influence on income-related health inequality. We found a significantly negative association between ANROA and the rate of physical inactivity: ANROA and the spatial effect explained 69%, nationwide, of the variation in physical inactivity. Physical inactivity rate showed a strong spatial dependence—influenced not only by its own in-county ANROA, but also by that of its neighbors ANROA. Furthermore, community groups at the same income level and with the highest ANROA, always had the lowest physical inactivity rate. This finding may help to guide future land use planning and community development that will benefit human health and well-being. PMID:27548195

  9. Association between Natural Resources for Outdoor Activities and Physical Inactivity: Results from the Contiguous United States.

    PubMed

    Jiang, Yan; Yuan, Yongping; Neale, Anne; Jackson, Laura; Mehaffey, Megan

    2016-08-17

    Protected areas including national/state parks and recreational waters are excellent natural resources that promote physical activity and interaction with Nature, which can relieve stress and reduce disease risk. Despite their importance, however, their contribution to human health has not been properly quantified. This paper seeks to evaluate quantitatively how national/state parks and recreational waters are associated with human health and well-being, taking into account of the spatial dependence of environmental variables for the contiguous U.S., at the county level. First, we describe available natural resources for outdoor activities (ANROA), using national databases that include features from the Protected Areas Database, NAVSTREETS, and ATTAINSGEO 305(b) Waters. We then use spatial regression techniques to explore the association of ANROA and socioeconomic status factors on physical inactivity rates. Finally, we use variance analysis to analyze ANROA's influence on income-related health inequality. We found a significantly negative association between ANROA and the rate of physical inactivity: ANROA and the spatial effect explained 69%, nationwide, of the variation in physical inactivity. Physical inactivity rate showed a strong spatial dependence-influenced not only by its own in-county ANROA, but also by that of its neighbors ANROA. Furthermore, community groups at the same income level and with the highest ANROA, always had the lowest physical inactivity rate. This finding may help to guide future land use planning and community development that will benefit human health and well-being.

  10. Recent studies on activated carbons and fly ashes from Turkish resources

    SciTech Connect

    Ayhan Demirbas; Gulsin Arslan; Erol Pehlivan

    2006-05-15

    This article deals with adsorptive properties of activated carbons (ACs) and fly ashes from Turkish coal and biomass resources. ACs because of their high surface area, microporous character and the chemical nature of their surface have been considered potential adsorbents for the removal of heavy metals from industrial wastewater. Pyrolysis is an established process method for preparation of activated carbon from biomass. The bio-char is can be used as AC. The adsorption properties of ACs were strictly defined by the physicochemical nature of their surface and their texture, i.e., pore volume, pore size distribution, surface area. It is well known that the pH of the solution-adsorbant mixture is an important variable in the adsorption process. Fly ash has the highest adsorption capacity (198.2 mg/g for Cd(II)). Almond shell AC has the lowest adsorption capacity (2.7 mg/g).

  11. Disturbance observer based active and adaptive synchronization of energy resource chaotic system.

    PubMed

    Wei, Wei; Wang, Meng; Li, Donghai; Zuo, Min; Wang, Xiaoyi

    2016-11-01

    In this paper, synchronization of a three-dimensional energy resource chaotic system is considered. For the sake of achieving the synchronization between the drive and response systems, two different nonlinear control approaches, i.e. active control with known parameters and adaptive control with unknown parameters, have been designed. In order to guarantee the transient performance, finite-time boundedness (FTB) and finite-time stability (FTS) are introduced in the design of active control and adaptive control, respectively. Simultaneously, in view of the existence of disturbances, a new disturbance observer is proposed to estimate the disturbance. The conditions of the asymptotic stability for the closed-loop system are obtained. Numerical simulations are provided to illustrate the proposed approaches.

  12. In-situ resource utilization activities at the NASA Space Engineering Research Center

    NASA Technical Reports Server (NTRS)

    Ramohalli, Kumar

    1992-01-01

    The paper describes theoretical and experimental research activities at the NASA Space Engineering Research Center aimed at realizing significant cost savings in space missions through the use of locally available resources. The fundamental strategy involves idea generation, scientific screening, feasibility demonstrations, small-scale process plant design, extensive testing, scale-up to realistic production rates, associated controls, and 'packaging', while maintaining sufficient flexibility to respond to national needs in terms of specific applications. Aside from training, the principal activities at the Center include development of a quantitative figure-of-merit to quickly assess the overall mission impact of individual components that constantly change with advancing technologies, extensive tests on a single-cell test bed to produce oxygen from carbon dioxide, and the use of this spent stream to produce methane.

  13. Environmental and resource implications of phosphorus recovery from waste activated sludge.

    PubMed

    Sørensen, Birgitte Lilholt; Dall, Ole Leinikka; Habib, Komal

    2015-11-01

    Phosphorus is an essential mineral resource for the growth of crops and thus necessary to feed the ever increasing global population. The essentiality and irreplaceability of phosphorus in food production has raised the concerns regarding the long-term phosphorus availability and the resulting food supply issues in the future. Hence, the recovery of phosphorus from waste activated sludge and other waste streams is getting huge attention as a viable solution to tackle the potential availability issues of phosphorus in the future. This study explores the environmental implications of phosphorus recovery from waste activated sludge in Denmark and further elaborates on the potential availability or scarcity issue of phosphorus today and 2050. Life cycle assessment is used to assess the possibility of phosphorus recovery with little or no environmental impacts compared to the conventional mining. The phosphorus recovery method assessed in this study consists of drying process, and thermal gasification of the waste activated sludge followed by extraction of phosphorus from the ashes. Our results indicate that the environmental impacts of phosphorus recovery in an energy efficient process are comparable to the environmental effects from the re-use of waste activated sludge applied directly on farmland. Moreover, our findings conclude that the general recommendation according to the waste hierarchy, where re-use of the waste sludge on farmland is preferable to material and energy recovery, is wrong in this case. Especially when phosphorus is a critical resource due to its life threatening necessity, lack of substitution options and potential future supply risk originating due to the high level of global supply concentration.

  14. Are nest sites actively chosen? Testing a common assumption for three non-resource limited birds

    NASA Astrophysics Data System (ADS)

    Goodenough, A. E.; Elliot, S. L.; Hart, A. G.

    2009-09-01

    Many widely-accepted ecological concepts are simplified assumptions about complex situations that remain largely untested. One example is the assumption that nest-building species choose nest sites actively when they are not resource limited. This assumption has seen little direct empirical testing: most studies on nest-site selection simply assume that sites are chosen actively (and seek explanations for such behaviour) without considering that sites may be selected randomly. We used 15 years of data from a nestbox scheme in the UK to test the assumption of active nest-site choice in three cavity-nesting bird species that differ in breeding and migratory strategy: blue tit ( Cyanistes caeruleus), great tit ( Parus major) and pied flycatcher ( Ficedula hypoleuca). Nest-site selection was non-random (implying active nest-site choice) for blue and great tits, but not for pied flycatchers. We also considered the relative importance of year-specific and site-specific factors in determining occupation of nest sites. Site-specific factors were more important than year-specific factors for the tit species, while the reverse was true for pied flycatchers. Our results show that nest-site selection, in birds at least, is not always the result of active choice, such that choice should not be assumed automatically in studies of nesting behaviour. We use this example to highlight the need to test key ecological assumptions empirically, and the importance of doing so across taxa rather than for single "model" species.

  15. Peroxisome Proliferator-Activated Receptor γ Activity is Required for Appropriate Cardiomyocyte Differentiation

    PubMed Central

    Peymani, Maryam; Ghaedi, Kamran; Irani, Shiva; Nasr-Esfahani, Mohammad Hossein

    2016-01-01

    Objective Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the PPAR nuclear receptor superfamily. Although PPARγ acts as a master transcription factor in adipocyte differentiation, it is also associated with a variety of cell functions including carbohydrate and lipid metabolism, glucose homeostasis, cell proliferation and cell differentiation. This study aimed to assess the expression level of PPARγ in order to address its role in cardiac cell differentiation of mouse embryonic stem cells (mESCs). Materials and Methods In this an intervening study, mESCs were subjected to cardiac differentiation. Total RNA was extracted from the cells and quantitative real time polymerase chain reaction (qPCR) was carried out to estimate level of gene expression. Furthermore, the requirement of PPARγ in cardiac differentiation of mESCs, during cardiac progenitor cells (CPCs) formation, was examined by applying the respective agonist and antagonist. Results The obtained data revealed an elevation in the expression level of PPARγ during spontaneous formation of CPCs and cardiomyocytes. Our results indicated that during CPC formation, PPARγ inactivation via treatment with GW9662 (GW) reduced expression of CPC and cardiac markers. Conclusion We conclude that PPARγ modulation has an effective role on cardiac differentiation of mESCs at the early stage of cardiomyogenesis. PMID:27540527

  16. Active Community-Based Case Finding for Tuberculosis With Limited Resources

    PubMed Central

    Karki, Bindu; Kittel, Guenter; Bolokon, Ignatius; Duke, Trevor

    2016-01-01

    Papua New Guinea is one of the 14 highest-burden countries for tuberculosis (TB) infection, but few community-based studies exist. We evaluated a low-cost method of active community case finding in Kabwum and Wasu in Morobe Province, Papua New Guinea. Over 3 months we visited 26 villages and screened adults and children for symptoms and signs of TB. Sputum samples were examined using smear microscopy. A total of 1700 people had chronic symptoms, of which 267 were suspicious for TB on further examination. Sputum from 230 symptomatic adults yielded 97 samples that were positive for acid-fast bacilli. In addition, 15 cases of extrapulmonary TB in adults and 17 cases of TB in children were identified. One hundred and thirty people were identified with active TB disease among the source population of approximately 17 000, giving an estimated prevalence of 765 per 100 000. One hundred and six (82%) cases were not previously diagnosed. The cost per case identified was US$146. It is feasible to conduct active community-based case finding and treatment initiation for TB with limited resources and in remote areas, and in Papua New Guinea the yield was high. Active case finding and follow-up of treatment in villages is needed to address the hidden burden of TB in Papua New Guinea and other high-burden Asia Pacific countries. PMID:28033717

  17. Microhabitat resource use, activity patterns, and episodic catastrophe: Conus on tropical intertidal reef rock benches

    SciTech Connect

    Leviten, P.J.; Kohn, A.J.

    1980-03-01

    Low species richness (five to nine species) and high population density (means of 0.2-8.6 individuals per square metre) characterize Conus assemblages on intertidal benches throughout the tropical Indo-West Pacific region. Data from 16 such habitats in Hawaii, Marshall Islands, Australia, Maldives, and Seychelles indicate that similarity of microhabitats between species is equal to or greater than random expectation. Significant between-species differences in zonation pattern occur across benches at a given time and place. The peak of C. ebraeus abundance typically occurs closest to shore; C. chaldaeus and C. sponsalis are usually most distant from shore. However, we found about as many significant within-species differences between censuses made at different times on the same bench as between-species differences within censuses. Co-occurring species thus tend not to use microhabitat resources differentially. Physical environmental variables including tide level, strength of water flow and time of day determine refuging and foraging activity patterns, and all species apear to respond similarly to these factors. The data thus do not support the hypothesis of temporal resource partitioning. We found evidence neither for homing, as mark-recapture results suggested that individuals occupy any convenient refuge after foraging, nor for interference competition for protected sites among Conus. Conus species diversity is significantly correlated with (1) substrate topographic diversity measured either independently or as the diversity of microhabitats utilized by all species together, and (2) the proportion of individuals occupying protected sites.

  18. 33 CFR 155.4045 - Required agreements or contracts with the salvage and marine firefighting resource providers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... with the salvage and marine firefighting resource providers. 155.4045 Section 155.4045 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Salvage and Marine Firefighting § 155.4045...

  19. 33 CFR 155.4045 - Required agreements or contracts with the salvage and marine firefighting resource providers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... with the salvage and marine firefighting resource providers. 155.4045 Section 155.4045 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Salvage and Marine Firefighting § 155.4045...

  20. 33 CFR 155.4045 - Required agreements or contracts with the salvage and marine firefighting resource providers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... with the salvage and marine firefighting resource providers. 155.4045 Section 155.4045 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Salvage and Marine Firefighting § 155.4045...

  1. 33 CFR 155.4045 - Required agreements or contracts with the salvage and marine firefighting resource providers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... with the salvage and marine firefighting resource providers. 155.4045 Section 155.4045 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Salvage and Marine Firefighting § 155.4045...

  2. Outreach and Engagement Education for Graduate Students in Natural Resources: Developing a Course to Enrich a Graduate Outreach Requirement

    ERIC Educational Resources Information Center

    Latimore, Jo A.; Dreelin, Erin A.; Burroughs, Jordan Pusateri

    2014-01-01

    Scientists need to engage stakeholders in natural resource management; however, few graduate programs prepare students to conduct outreach and engagement. Given this need, the authors' goals were to (1) create a one-credit course that introduced outreach and engagement practices and participatory approaches, (2) improve the quality of graduate…

  3. [Activating physiotherapy for chronic pain in elderly patients. Recommendations, barriers and resources].

    PubMed

    Kuss, K; Laekeman, M

    2015-08-01

    Elderly patients with chronic pain are particularly at risk of functional limitations up to the loss of autonomy and social life. To facilitate autonomy, mobility and quality of life, physiotherapy plays an essential role in pain management. Nevertheless, programs that are specifically geared towards the needs of older patients are still uncommon. This article offers recommendations for structuring physiotherapy programs based on international guideline recommendations. First examples of pain management concepts for older adults demonstrate the positive results of activating therapy. Additionally, this article provides insights into barriers and resources of affected patients and all actors involved. However, physiotherapeutic treatment for aged chronic pain patients in Germany still shows considerable shortcomings but also offers an exciting challenge for the future.

  4. NASA Propulsion Concept Studies and Risk Reduction Activities for Resource Prospector Lander

    NASA Technical Reports Server (NTRS)

    Trinh, Huu P.; Williams, Hunter; Burnside, Chris

    2015-01-01

    The Resource Prospector mission is to investigate the Moon's polar regions in search of volatiles. The government-version lander concept for the mission is composed of a braking stage and a liquid-propulsion lander stage. A propulsion trade study concluded with a solid rocket motor for the braking stage while using the 4th-stage Peacekeeper (PK) propulsion components for the lander stage. The mechanical design of the liquid propulsion system was conducted in concert with the lander structure design. A propulsion cold-flow test article was fabricated and integrated into a lander development structure, and a series of cold flow tests were conducted to characterize the fluid transient behavior and to collect data for validating analytical models. In parallel, RS-34 PK thrusters to be used on the lander stage were hot-fire tested in vacuum conditions as part of risk reduction activities.

  5. dbCAN: a web resource for automated carbohydrate-active enzyme annotation.

    PubMed

    Yin, Yanbin; Mao, Xizeng; Yang, Jincai; Chen, Xin; Mao, Fenglou; Xu, Ying

    2012-07-01

    Carbohydrate-active enzymes (CAZymes) are very important to the biotech industry, particularly the emerging biofuel industry because CAZymes are responsible for the synthesis, degradation and modification of all the carbohydrates on Earth. We have developed a web resource, dbCAN (http://csbl.bmb.uga.edu/dbCAN/annotate.php), to provide a capability for automated CAZyme signature domain-based annotation for any given protein data set (e.g. proteins from a newly sequenced genome) submitted to our server. To accomplish this, we have explicitly defined a signature domain for every CAZyme family, derived based on the CDD (conserved domain database) search and literature curation. We have also constructed a hidden Markov model to represent the signature domain of each CAZyme family. These CAZyme family-specific HMMs are our key contribution and the foundation for the automated CAZyme annotation.

  6. A structure-activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activity

    PubMed Central

    Kim, Seong Jong; Lin, Chun Chieh; Pan, Chung-Mao; Rananaware, Dimple P.; Ramsey, Deborah M.

    2013-01-01

    We report the synthesis, cytotoxicity, and phenotypic analysis of oxazole and thiazole containing fragments. Evaluating the optimal size and heterocycle for growth inhibition and apoptosis showed that activity required at least two thiazoles sequentially connected. This is the first detailed comparison of biological activity between multi-heterocyclic containing fragments. PMID:23524379

  7. 77 FR 27539 - Reports, Forms, and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... instrumented motorcycles. The National Highway Traffic Safety Administration (NHTSA) will be conducting on-road... National Highway Traffic Safety Administration Reports, Forms, and Recordkeeping Requirements; Agency Information Collection Activity Under OMB Review AGENCY: National Highway Traffic Safety Administration...

  8. 75 FR 36637 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... COMMISSION Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for... comment on the proposed collection of certain information by the agency. Under the Paperwork Reduction Act... concerning each proposed collection of information, including each proposed extension of an...

  9. 75 FR 36638 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    ... COMMISSION Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements for... the proposed collection of certain information by the agency. Under the Paperwork Reduction Act of... each proposed collection of information, including each proposed extension of an existing collection...

  10. 76 FR 66127 - Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... Maritime Administration Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB Review AGENCY: Maritime Administration, DOT. ACTION: Notice and request for comments... November 25, 2011. FOR FURTHER INFORMATION CONTACT: Dennis Brennan, Maritime Administration, 1200...

  11. 77 FR 26824 - Agency Information Collection; Activity Under OMB Review; Reporting Required for International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... Research & Innovative Technology Administration Agency Information Collection; Activity Under OMB Review; Reporting Required for International Civil Aviation Organization (ICAO) AGENCY: Research & Innovative..., Research and Innovative Technology Administration. BILLING CODE 4910-HY-P...

  12. 76 FR 24561 - Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... Maritime Administration Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB Review AGENCY: Maritime Administration, DOT. ACTION: Notice and request for comments... Administration (MARAD). Title: MARAD's Marine Transportation Economic Impact Model Data Needs. OMB Control...

  13. Requirements for 5′dRP/AP lyase activity in Ku

    PubMed Central

    Strande, Natasha T.; Carvajal-Garcia, Juan; Hallett, Ryan A.; Waters, Crystal A.; Roberts, Steven A.; Strom, Christina; Kuhlman, Brian; Ramsden, Dale A.

    2014-01-01

    The non-homologous end joining (NHEJ) pathway is used in diverse species to repair chromosome breaks, and is defined in part by a requirement for Ku. We previously demonstrated mammalian Ku has intrinsic 5′ deoxyribosephosphate (5′dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed this activity is important for excising abasic site damage from ends. Here we employ systematic mutagenesis to clarify the protein requirements for this activity. We identify lysine 31 in the 70 kD subunit (Ku70 K31) as the primary candidate nucleophile required for catalysis, but additional mutation of Ku70 K160 and six other lysines within Ku80 were required to eliminate all activity. Ku from Saccharomyces cerevisiae also possesses 5′dRP/AP lyase activity, and robust activity was also reliant on lysines in Ku70 analogous to K31 and K160. By comparison, these lysines are not conserved in Xenopus laevis Ku, and Ku from this species has negligible activity. A role for residues flanking Ku70 K31 in expanding the range of abasic site contexts that can be used as substrate was also identified. Our results suggest an active site well located to provide the substrate specificity required for its biological role. PMID:25200085

  14. Models of Traumatic Experiences and Children's Psychological Adjustment: The Roles of Perceived Parenting and the Children's Own Resources and Activity.

    ERIC Educational Resources Information Center

    Punamaki, Raija-Leena; Qouta, Samir; El Sarraj, Eyad

    1997-01-01

    Used path analysis to examine relations between trauma, perceived parenting, resources, political activity, and adjustment in Palestinian 11- and 12-year olds. Found that the more trauma experienced, the more negative parenting the children experienced, the more political activity they showed, and the more they suffered from adjustment problems.…

  15. Teaching Strategies - Grades 3-4. Master Curriculum Guide in Economics. Teacher Resource Manual [and] Student Activities.

    ERIC Educational Resources Information Center

    Lieb, Cynthia; Stout, Robert L.

    This teacher resource manual for 3rd-and 4th-grade student's uses a wide variety of instructional activities for teaching economics education. The activities include role playing in small groups, producing bookmarks, and making decisions. Students are given the opportunity to interview adults, perform services for their families, do independent…

  16. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain...

  17. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain...

  18. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain...

  19. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain...

  20. 10 CFR 60.7 - License not required for certain preliminary activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false License not required for certain preliminary activities. 60.7 Section 60.7 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.7 License not required for certain...