Sample records for activities teaching tips

  1. [Providing successful education and further training: 10 tips].

    PubMed

    Brand, Paul L P; Boendermaker, Peter M; Venekamp, Ruud M

    2014-01-01

    Almost all physicians teach or provide postgraduate medical education from time to time. Although many people assume that there are 'born teachers' and 'those who will never learn to teach', teaching is an ability. The knowledge and skills required to teach well can be learned and practised. In this review article, we present 10 tips that will help the busy clinician to teach effectively. The 10 tips, which are based on the principles of adult learning, are: prepare your teaching session, involve the learners actively, connect to the learners' level of competence, define learning objectives, make the subject of your teaching relevant to the learners, use questions, be a good role model, vary your teaching methods, practise your teaching, and limit the amount of material you are teaching in each session.

  2. Teaching & Learning Tips 1: Teaching perspectives - an introduction.

    PubMed

    Rana, Jasmine; Burgin, Susan

    2017-11-01

    Challenge: Clinical and research responsibilities often leave little or no time to plan thoughtful teaching encounters with trainees. This "Teaching & Learning Tips" series is designed to be an accessible guide for dermatologists who want to improve their teaching skills. It is comprised of 12 articles about how to enhance teaching in various settings informed by research about how people learn and expert-derived or data-driven best practices for teaching. The series begins with a review of principles to optimize learning in any setting, including cognitive load theory, active learning strategies, and the impact of motivation and emotion on learning. It transitions into a practical "how to" guide format for common teaching scenarios in dermatology, such as lecturing, case-based teaching, and teaching procedures, among others. Herein, we kickoff the series by unpacking assumptions about teaching and learning. What does it mean to teach and learn? © 2017 The International Society of Dermatology.

  3. Twelve tips to stimulate intrinsic motivation in students through autonomy-supportive classroom teaching derived from self-determination theory.

    PubMed

    Kusurkar, R A; Croiset, G; Ten Cate, Th J

    2011-01-01

    Self-determination theory (SDT) of motivations distinguishes between intrinsic and extrinsic motivations. Intrinsic motivation is observed when one engages in an activity out of genuine interest and is truly self-determined. Intrinsic motivation is the desired type of motivation for study as it is associated with deep learning, better performance and positive well-being in comparison to extrinsic motivation. It is dependent on the fulfilment of three basic psychological needs described by SDT. These are the needs for autonomy, competence and relatedness. According to SDT, autonomy-supportive teaching is important, because it makes students feel autonomous and competent in their learning and also supported (relatedness) by their teachers. The concept of autonomy-supportive teaching is relevant to medical education, but less known. Through this article, we aim to make this concept understood and practically used by medical teachers. We used SDT literature as a basis to formulate these 12 tips. We present 12 practical tips derived from SDT, for teachers in health professions, on how to engage in autonomy-supportive teaching behaviours in order to stimulate intrinsic motivation in their students. These tips demonstrate that it is not difficult to engage in autonomy-supportive teaching behaviour. It can be learned through practice and self-reflection on teaching practices.

  4. Seeing and Doing Science--With Video.

    ERIC Educational Resources Information Center

    Berger, Michelle Abel

    1994-01-01

    The article presents a video-based unit on camouflage for students in grades K-5, explaining how to make the classroom VCR a dynamic teaching tool. Information is offered on introducing the unit, active viewing strategies, and follow-up activities. Tips for teaching with video are included. (SM)

  5. Tips for Teaching Birding.

    ERIC Educational Resources Information Center

    Burtch, Bob

    1986-01-01

    Provides descriptions of indoor and outdoor activities that can be used in teaching a unit on birds. Suggests techniques that can be helpful in bird identification. Includes a reference list of audiovisual materials, books, and field guides on birds. (ML)

  6. Writing IS Teaching Tips: Guidelines for "JISE" Submission

    ERIC Educational Resources Information Center

    Lending, Diane; Vician, Chelley

    2012-01-01

    "JISE" has a lengthy history of inviting the submission of Teaching Tips for publication consideration in the journal. Past submission guidance for Teaching Tips has consisted of asking contributors to document the teaching experience and indicate what has worked, and not worked, in its execution within a journal page constraint of one to five…

  7. Teaching Tip: Using Activity Diagrams to Model Systems Analysis Techniques: Teaching What We Preach

    ERIC Educational Resources Information Center

    Lending, Diane; May, Jeffrey

    2013-01-01

    Activity diagrams are used in Systems Analysis and Design classes as a visual tool to model the business processes of "as-is" and "to-be" systems. This paper presents the idea of using these same activity diagrams in the classroom to model the actual processes (practices and techniques) of Systems Analysis and Design. This tip…

  8. Teaching Typography.

    ERIC Educational Resources Information Center

    Communication: Journalism Education Today, 1998

    1998-01-01

    Outlines nine objectives students should be able to accomplish after completing the activities in the unit on typography presented in the previous articles in this journal. Offers eight tips for teaching typography. Includes a short list of books about typography and a list of seven organizations. (SR)

  9. Twelve tips for teaching in a provincially distributed medical education program.

    PubMed

    Wong, Roger Y; Chen, Luke; Dhadwal, Gurbir; Fok, Mark C; Harder, Ken; Huynh, Hanh; Lunge, Ryan; Mackenzie, Mark; Mckinney, James; Ovalle, William; Rauniyar, Pooja; Tse, Luke; Villanyi, Diane

    2012-01-01

    As distributed undergraduate and postgraduate medical education becomes more common, the challenges with the teaching and learning process also increase. To collaboratively engage front line teachers in improving teaching in a distributed medical program. We recently conducted a contest on teaching tips in a provincially distributed medical education program and received entries from faculty and resident teachers. Tips that are helpful for teaching around clinical cases at distributed teaching sites include: ask "what if" questions to maximize clinical teaching opportunities, try the 5-min short snapper, multitask to allow direct observation, create dedicated time for feedback, there are really no stupid questions, and work with heterogeneous group of learners. Tips that are helpful for multi-site classroom teaching include: promote teacher-learner connectivity, optimize the long distance working relationship, use the reality television show model to maximize retention and captivate learners, include less teaching content if possible, tell learners what you are teaching and make it relevant and turn on the technology tap to fill the knowledge gap. Overall, the above-mentioned tips offered by front line teachers can be helpful in distributed medical education.

  10. Teaching Tip: Active Learning via a Sample Database: The Case of Microsoft's Adventure Works

    ERIC Educational Resources Information Center

    Mitri, Michel

    2015-01-01

    This paper describes the use and benefits of Microsoft's Adventure Works (AW) database to teach advanced database skills in a hands-on, realistic environment. Database management and querying skills are a key element of a robust information systems curriculum, and active learning is an important way to develop these skills. To facilitate active…

  11. Some Techniques for Teaching about the Structure and Function of Chromosomes.

    ERIC Educational Resources Information Center

    Lowery, Roger; Taylor, Neil; Nathan, Subhashni

    2000-01-01

    Presents a teaching activity that uses photographs and diagrams to simulate two microscopic laboratory techniques used to observe the structure of chromosomes. Techniques include observation of squashed onion root tips and the salivary glands of some fruitfly larvae. (WRM)

  12. "Date with an Angel": A Non-Verbal Communication Teaching Tip.

    ERIC Educational Resources Information Center

    Long, Toni

    This paper presents a strategy for teaching non-verbal communication skills to students in high school or college. The strategy uses the movie "Date with an Angel" to teach the non-verbal skills. According to the paper, the activity can be used at the beginning of a unit or course to get the students interested in important…

  13. Ten Timeless Tips for Keeping on Top of Teaching Technology

    ERIC Educational Resources Information Center

    Poling, Devereaux A.; LoSchiavo, Frank M.

    2014-01-01

    We provide tips for helping psychology faculty effectively seek, select, and place new technology into pedagogical practice. We also provide tips to help psychology departments position themselves for a future that includes teaching technologies that have not yet been created. Instead of discussing today's top innovations in teaching (which…

  14. Report on using TIPS (Teaching Information Processing System) in teaching physics and astronomy

    NASA Astrophysics Data System (ADS)

    Folland, Nathan O.; Marchini, Robert R.; Rhyner, Charles R.; Zeilik, Michael

    1983-05-01

    A computer-managed instruction system, TIPS, has been used for over a decade in the teaching of diverse disciplines. This paper describes the recent use of TIPS in physics and astronomy courses at Kansas State University, Memphis State University, University of New Mexico, and University of Wisconsin-Green Bay. Student reactions to TIPS were largely positive, but the degree of success in improving student performance reported in many articles has not been observed.

  15. #MoreThanEdChats

    ERIC Educational Resources Information Center

    Mieliwocki, Rebecca

    2015-01-01

    This article describes three reasons Twitter has become an essential part of US National Teacher of the Year Rebecca Mieliwocki's teaching life: (1) It provides professional development on demand by offering a steady stream of great new ideas, activities, lesson suggestions, book recommendations, and teaching tips that can be immediately…

  16. Results from a Faculty Development Program in Teaching Economics

    ERIC Educational Resources Information Center

    Walstad, William B.; Salemi, Michael K.

    2011-01-01

    The Teaching Innovations Program (TIP) was a six-year project funded by the National Science Foundation that gave economics instructors the opportunity to learn interactive teaching strategies for use in undergraduate economics courses. TIP participants first attended a teaching workshop that presented various teaching strategies. They then could…

  17. Twelve tips for overnight teaching.

    PubMed

    Richards, Jeremy B; Wilcox, Susan R; Roberts, David H; Schwartzstein, Richard M

    2014-03-01

    The European Working Time Directive and the United States' duty hour restrictions have changed resident physicians' schedules, specifically increasing overnight shifts and decreasing overall time spent in the hospital. As residents' perception of night shifts is that they have little educational value, efforts to improve educational opportunities and night attending teaching are desirable. However, resources about and recommendations for best practices for overnight teaching by faculty are scarce. To provide 12 tips to highlight strategies intended to optimize attending physicians' overnight teaching skills and strategies. The tips provided are based on our experiences and reflections as in-house faculty supervising residents working overnight, by our experience and group discussions as medical educators, and the available literature. The 12 tips presented offer specific strategies to optimize attending physicians' overnight teaching for resident physicians, specifically highlighting the unique logistics, pedagogy and follow-up of overnight teaching. Preparation for teaching is important in any environment, but understanding the unique timing and circumstances associated with overnight teaching is vital to ensure that overnight teaching is effective. Acknowledging and addressing the physical and cognitive obstacles associated with overnight teaching and learning is necessary to maximize the educational value of overnight teaching.

  18. TIPS: Crime Resistance Strategies, 6. Teaching Individuals Protective Strategies, Teaching Individuals Positive Solutions.

    ERIC Educational Resources Information Center

    Bass, Martha; And Others

    This booklet outlines activities and objectives for a crime prevention education program in the sixth grade. The document is part of a K-eighth grade crime resistance project designed to promote and maintain positive student attitudes and behavior, to assist students in meeting their responsibilities, and to help them insure their own and other…

  19. The Classroom Percussionist

    ERIC Educational Resources Information Center

    Marshall, Herbert D.

    2006-01-01

    The article offers tips on introducing percussion activities in elementary music class. Percussion equipment should be treated as musical instruments and not toys, teaching correct names, playing techniques and notation for the instruments. Active listening experiences for students should be planned, including band music. Band music incorporates…

  20. Tips for Teachers of Evidence-based Medicine: Clinical Prediction Rules (CPRs) and Estimating Pretest Probability

    PubMed Central

    McGinn, Thomas; Jervis, Ramiro; Wisnivesky, Juan; Keitz, Sheri

    2008-01-01

    Background Clinical prediction rules (CPR) are tools that clinicians can use to predict the most likely diagnosis, prognosis, or response to treatment in a patient based on individual characteristics. CPRs attempt to standardize, simplify, and increase the accuracy of clinicians’ diagnostic and prognostic assessments. The teaching tips series is designed to give teachers advice and materials they can use to attain specific educational objectives. Educational Objectives In this article, we present 3 teaching tips aimed at helping clinical learners use clinical prediction rules and to more accurately assess pretest probability in every day practice. The first tip is designed to demonstrate variability in physician estimation of pretest probability. The second tip demonstrates how the estimate of pretest probability influences the interpretation of diagnostic tests and patient management. The third tip exposes learners to various examples and different types of Clinical Prediction Rules (CPR) and how to apply them in practice. Pilot Testing We field tested all 3 tips with 16 learners, a mix of interns and senior residents. Teacher preparatory time was approximately 2 hours. The field test utilized a board and a data projector; 3 handouts were prepared. The tips were felt to be clear and the educational objectives reached. Potential teaching pitfalls were identified. Conclusion Teaching with these tips will help physicians appreciate the importance of applying evidence to their every day decisions. In 2 or 3 short teaching sessions, clinicians can also become familiar with the use of CPRs in applying evidence consistently in everyday practice. PMID:18491194

  1. Tips for using mobile audience response systems in medical education

    PubMed Central

    Gousseau, Michael; Sommerfeld, Connor; Gooi, Adrian

    2016-01-01

    Background With growing evidence on the benefits of active learning, audience response systems (ARSs) have been increasingly used in conferences, business, and education. With the introduction of mobile ARS as an alternative to physical clickers, there are increasing opportunities to use this tool to improve interactivity in medical education. Aim The aim of this study is to provide strategies on using mobile ARS in medical education by discussing steps for implementation and pitfalls to avoid. Method The tips presented reflect our commentary of the literature and our experiences using mobile ARS in medical education. Results This article offers specific strategies for the preparation, implementation, and assessment of medical education teaching sessions using mobile ARS. Conclusion We hope these tips will help instructors use mobile ARS as a tool to improve student interaction, teaching effectiveness, and participant enjoyment in medical education. PMID:27942242

  2. Teaching Poetry Tips; Teaching English without Desks; A Brief History of Time and the "Red Clock."

    ERIC Educational Resources Information Center

    Reid, Gem; And Others

    1993-01-01

    This issue of "Insights into Open Education" presents three short articles dealing with teaching poetry, English instruction, and the concept of time. The first article, "Teaching Poetry Tips" (Gem Reid), discusses the author's experiences conducting a week-long poetry workshop for a class of 30 second graders. The second article, "Teaching…

  3. Classroom Tips.

    ERIC Educational Resources Information Center

    Crain, Cheryl

    1994-01-01

    Presents six teaching ideas from teachers in Foothills Schools, Alberta, Canada. Includes suggested activities on local government, computer uses in social studies, Canadian history, current events, and world studies. Provides models of a passport application, passports, and visas. (CFR)

  4. Make It Metric.

    ERIC Educational Resources Information Center

    Camilli, Thomas

    Measurement is perhaps the most frequently used form of mathematics. This book presents activities for learning about the metric system designed for upper intermediate and junior high levels. Discussions include: why metrics, history of metrics, changing to a metric world, teaching tips, and formulas. Activities presented are: metrics all around…

  5. Making Good Teaching Great: Everyday Strategies for Teaching with Impact

    ERIC Educational Resources Information Center

    Breaux, Annette L.; Whitaker, Todd

    2012-01-01

    Every good teacher strives to be a great teacher--and this must-have book shows you how! It's filled with practical tips and strategies for connecting with your students in a meaningful and powerful way. Learn how to improve student learning with easy-to-implement daily activities designed to integrate seamlessly into any day of the school year.…

  6. "Teaching Tip": An Introduction to the Business Game "Flowers for the World"

    ERIC Educational Resources Information Center

    Moores, Trevor T.

    2016-01-01

    The aim of this paper is to provide sufficient detail that other members of the IS community can incorporate the business game "Flowers for the World" (or FFTW for short) into their IS teaching portfolio. The game promotes experiential (active) learning and has been used to support discussions or project work in such diverse subjects as…

  7. Histograms and Frequency Density.

    ERIC Educational Resources Information Center

    Micromath, 2003

    2003-01-01

    Introduces exercises on histograms and frequency density. Guides pupils to Discovering Important Statistical Concepts Using Spreadsheets (DISCUSS), created at the University of Coventry. Includes curriculum points, teaching tips, activities, and internet address (http://www.coventry.ac.uk/discuss/). (KHR)

  8. MS Is a Family Affair. Revised Edition.

    ERIC Educational Resources Information Center

    Braunel, Laura M.; And Others

    The booklet offers practical suggestions to teach the person with multiple sclerosis to conserve energy and maintain a balance between rest and activity. The discussion centers around personal hygiene, homemaking activities, family relationships, and hobbies. Another section gives tips for getting around in the community, with considerations for…

  9. Eight Stars of Gold--The Story of Alaska's Flag. Middle School Activities (Grades 6-8).

    ERIC Educational Resources Information Center

    Alaska State Museum, Juneau.

    This activities booklet focuses on the story of Alaska's state flag. The booklet is for use in teaching middle school students. Each activity contains: background information, a summary and time estimate, Alaska state standards, a step-by-step technique for classroom implementation of the activity, assessment tips, materials and resources needed,…

  10. Eight Stars of Gold--The Story of Alaska's Flag. High School Activities (Grades 9-12).

    ERIC Educational Resources Information Center

    Alaska State Museum, Juneau.

    This activities booklet focuses on the story of Alaska's flag. The booklet is intended for use in teaching high school students. Each activity contains: background information; a summary and time estimate, Alaska state standards, a step-by-step technique for classroom implementation of the activity, assessment tips, materials and resources needed,…

  11. Twelve tips for using applied improvisation in medical education.

    PubMed

    Hoffmann-Longtin, Krista; Rossing, Jonathan P; Weinstein, Elizabeth

    2018-04-01

    Future physicians will practice medicine in a more complex environment than ever, where skills of interpersonal communication, collaboration and adaptability to change are critical. Applied improvisation (or AI) is an instructional strategy which adapts the concepts of improvisational theater to teach these types of complex skills in other contexts. Unique to AI is its very active teaching approach, adapting theater games to help learners meet curricular objectives. In medical education, AI is particularly helpful when attempting to build students' comfort with and skills in complex, interpersonal behaviors such as effective listening, person-centeredness, teamwork and communication. This article draws on current evidence and the authors' experiences to present best practices for incorporating AI into teaching medicine. These practical tips help faculty new to AI get started by establishing goals, choosing appropriate games, understanding effective debriefing, considering evaluation strategies and managing resistance within the context of medical education.

  12. Twelve tips on teaching and learning humanism in medical education.

    PubMed

    Cohen, Libby Gordon; Sherif, Youmna Ashraf

    2014-08-01

    The teaching of humanistic values is recognized as an essential component of medical education and continuing professional development of physicians. The application of humanistic values in medical care can benefit medical students, clinicians and patients. This article presents 12 tips on fostering humanistic values in medical education. The authors reviewed the literature and present 12 practical tips that are relevant to contemporary practices. The tips can be used in teaching and sustaining humanistic values in medical education. Humanistic values can be incorporated in formal preclinical environments, the transition into clinical settings, medical curricula and clinical clerkships. Additionally, steps can be taken so that medical educators and institutions promote and sustain humanistic values.

  13. Celebrate the Earth...Every Day!

    ERIC Educational Resources Information Center

    Laubenthal, Gail

    1995-01-01

    Discusses the importance of teaching young children to appreciate and care for the earth and how to integrate earth activities into the curriculum. Includes a year-round curriculum with ideas for hands-on activities appropriate to each month, an integrated unit called "Flowers Blooming," tips for evaluating science experiences, and a…

  14. Planting Seeds in Young Minds.

    ERIC Educational Resources Information Center

    Pugh, Ava F.; Dukes-Bevans, Lenell

    1987-01-01

    Provides some teaching tips for elementary teachers that are designed to enhance the natural interests of young children in science and help equip them with important science processing skills. Contains activities related to observation, classification, measurement, and communication. (TW)

  15. Bryophyllum pinnatum: A Great Teaching Aid.

    ERIC Educational Resources Information Center

    Martin, Francis L.

    1983-01-01

    Suggests using Bryophyllum pinnatum to illustrate botanical principles. Includes tips for keeping and maintaining the plant in the classroom and suggests several student activities, including observing root/shoot growth, investigating apical dominance, exploring multiple leaf development, and others. (JN)

  16. Patient Activated Care for Rural Elderly. A Program Development and Teaching Guide for Planners, Facilitators, and Coordinators.

    ERIC Educational Resources Information Center

    Gaarder, Lorin R.; Cohen, Saul

    This guide is an outline for developing and presenting programs in self health care for senior citizens. The guide is presented in two sections. The first section provides background information about elderly self-care and tips on teaching it and developing a program. Sample letters to prospective enrollees and sample news releases are included.…

  17. Teaching American History: Structured Inquiry Approaches. SSEC Publication No. 185.

    ERIC Educational Resources Information Center

    Linden, Glenn M., Ed.; Downey, Matthew T., Ed.

    This paper is one of a series of ERIC/ChESS publications intended to give practical tips on teaching various topics and disciplines in the precollege social studies curriculum. The tips offered in this publication, written by seven authors, are intended to help teacheres deal with both content and teaching strategies in American history. Each of…

  18. Middle Years. For Middle Level Educators.

    ERIC Educational Resources Information Center

    Hechinger, Fred M.; And Others

    1992-01-01

    This supplement offers 10 articles focusing on middle school education. Topics include remembering adolescence, resources and teaching tips, active middle school students, adolescent development, challenges in middle school education, integrated studies, planning middle school special events, a writing-science-consumerism miniunit on popcorn,…

  19. A Learning Cycle Approach To Introducing Osmosis.

    ERIC Educational Resources Information Center

    Lawson, Anton E.

    2000-01-01

    Presents an inquiry activity with a learning cycle approach to engage students in testing their own hypotheses about how molecules move through cell membranes. Offers student materials and teacher materials, including teaching tips for each phase of the learning cycle. (Contains 11 references.) (ASK)

  20. Tips from the Classroom: Introducing the Friendly and Useful Computer; Using Annotations to Identify Composition Errors; Building a Scaffold with Video Clips; Movie Karaoke; Gotcha.

    ERIC Educational Resources Information Center

    Dudley, Albert P.; And Others

    1997-01-01

    Presents various tips that are useful in the classroom for teaching second languages. These tips focus on teaching basic computer operations; using annotations to foster error corrections in language; using video clips as a part of a U.S. history or culture-based English-as-a-Second-Language lesson; using karaoke to speak with less inhibition; and…

  1. An Interprofessional Web-Based Resource for Health Professions Preceptors

    PubMed Central

    McLeod, Elizabeth; Kwong, Mona; Tidball, Glynnis; Collins, John; Neufeld, Lois; Drynan, Donna

    2012-01-01

    Objective. To develop a Web-based preceptor education resource for healthcare professionals and evaluate its usefulness. Methods. Using an open source platform, 8 online modules called “E-tips for Practice Education” (E-tips) were developed that focused on topics identified relevant across healthcare disciplines. A cross-sectional survey design was used to evaluate the online resource. Ninety preceptors from 10 health disciplines affiliated with the University of British Columbia evaluated the E-tips. Results. The modules were well received by preceptors, with all participants indicating that they would recommend these modules to their colleagues, over 80% indicating the modules were very to extremely applicable, and over 60% indicating that E-tips had increased their confidence in their ability to teach. Conclusion. Participants reported E-tips to be highly applicable to their teaching role as preceptors. Given their multidisciplinary focus, these modules address a shared language and ideas about clinical teaching among those working in multi-disciplinary settings. PMID:23193332

  2. Safety Tips from the Expert Witness.

    ERIC Educational Resources Information Center

    Gray, Gary R.

    1995-01-01

    Many physical educators and coaches use the potential for liability to guide their decisions about conducting activities. By understanding expert witnesses' roles in negligence actions, surer planning, teaching, and coaching are possible. The paper describes issues that expert witnesses examine in negligence actions against physical educators,…

  3. Girls & Technology: An Idea Book for Educators & Parents.

    ERIC Educational Resources Information Center

    National Coalition of Girls' Schools, Concord, MA.

    This booklet represents an effort to combine research findings, strategies, teaching and parenting tips, activities, career profiles, and print and online information that can help make technology more accessible to girls. Chapters include: "Why a Focus on Girls & Technology: New Priorities"; "Girls & Technology: Different…

  4. Teaching Television Watchers.

    ERIC Educational Resources Information Center

    Dunn, Judy Lee

    1994-01-01

    Presents activities to help teachers address the needs and behaviors of students raised on television; includes resources to help teachers use television productively in the classroom, a send-home reproducible on children and television violence, and notes on an interview with Shari Lewis and television tips for primary students. (SM)

  5. Tips to Make Fast Food Friendlier for Kids

    MedlinePlus

    ... Hey Kids, Learn About Blood Sugar and Diabetes Teaching Gardens Teaching Gardens Recognition Teaching Gardens-See Our Gardens How to Get a Teaching Garden Teaching Gardens-Donate Teaching Gardens Photos and ...

  6. Twelve tips for the effective use of videos in medical education.

    PubMed

    Dong, Chaoyan; Goh, Poh Sun

    2015-02-01

    Videos can promote learning by either complementing classroom activities, or in self-paced online learning modules. Despite the wide availability of online videos in medicine, it can be a challenge for many educators to decide when videos should be used, how to best use videos, and whether to use existing videos or produce their own. We outline 12 tips based on a review of best practices in curriculum design, current research in multimedia learning and our experience in producing and using educational videos. The 12 tips review the advantages of using videos in medical education, present requirements for teachers and students, discuss how to integrate video into a teaching programme, and describe technical requirements when producing one's own videos. The 12 tips can help medical educators use videos more effectively to promote student engagement and learning.

  7. Tips, Tropes, and Trivia: Ideas for Teaching Educational Research.

    ERIC Educational Resources Information Center

    Stallings, William M.; And Others

    The collective experience of more than 50 years has led to the development of approaches that have enhanced student comprehension in the teaching of educational research methods, statistics, and measurement. Tips for teachers include using illustrative problems with one-digit numbers, using common situations and everyday objects to illustrate…

  8. Keep It Simple. Teaching Tips for Special Olympic Athletes.

    ERIC Educational Resources Information Center

    Johnston, Judith E.; And Others

    1996-01-01

    Physical educators can help Special Olympics athletes learn cross-lateral delivery techniques for bowling or throwing softballs by color coding the throwing arm and opposing foot. The article explains color coding, presenting teaching tips for both sports. A series of workshops on modifying exercise principles for individuals with physical…

  9. The Micro TIPS - Cases - Programmed Learning Course Package.

    ERIC Educational Resources Information Center

    Heriot-Watt Univ., Edinburgh (Scotland). Esmee Fairbairn Economics Research Centre.

    Part of an economic education series, the course package is designed to teach basic concepts and principles of microeconomics and how they can be applied to various world problems. For use with college students, learning is gained through lectures, tutorials, textbooks, programmed text, cases, and TIPS (Teaching Information Processing System).…

  10. Teaching Tip: Adding Intercultural Communication to an IS Curriculum

    ERIC Educational Resources Information Center

    Mitchell, Alanah; Benyon, Rob

    2018-01-01

    Increasingly, today's information systems (IS) programs are focused on making sure students are graduating with well-developed soft skills. One of these necessary soft skills is intercultural communication, which is the ability to communicate with people from different cultures. This teaching tip presents an assignment designed to increase the…

  11. Help Children--and Families--Learn Basic Fire Safety.

    ERIC Educational Resources Information Center

    Texas Child Care, 2001

    2001-01-01

    Presents tips to help early childhood teachers and caregivers teach young children fire safety. Provides checklist for preventing fires in the kitchen, classrooms, and storage areas. Offers suggestions for classroom learning activities and for educating families about fire safety. Includes annotated bibliography of children's books dealing with…

  12. Making Meaning through Translanguaging in the Literacy Classroom

    ERIC Educational Resources Information Center

    Pacheco, Mark B.; Miller, Mary E.

    2016-01-01

    In this Teaching Tip, we share three literacy activities for teachers working with emergent bilinguals. Leveraging students' heritage languages in instruction holds rich opportunities for literacy achievement. Translanguaging pedagogies encourage emergent bilinguals to use the full range of their linguistic repertoires when making meaning in the…

  13. Crutches and children - proper fit and safety tips

    MedlinePlus

    ... 000640.htm Crutches and children - proper fit and safety tips To use the sharing features on this ... the crutch, then extended when taking a step. Safety Tips Teach your child to: Always keep crutches ...

  14. Writing with Voice

    ERIC Educational Resources Information Center

    Kesler, Ted

    2012-01-01

    In this Teaching Tips article, the author argues for a dialogic conception of voice, based in the work of Mikhail Bakhtin. He demonstrates a dialogic view of voice in action, using two writing examples about the same topic from his daughter, a fifth-grade student. He then provides five practical tips for teaching a dialogic conception of voice in…

  15. Getting Along with Others: An Activity Book. Charts and Tips To Help You Teach Social Skills to Children and Reward Their Good Behavior. Grades Pre K-6.

    ERIC Educational Resources Information Center

    Herron, Ron

    Noting that children need to learn to cooperate with peers, older children, adults, and parents, this activity book presents 30 charts to help parents help their children learn and practice social skills. The illustrations, coloring activities, and rewards for parents to offer are designed to keep children entertained and motivated. The book…

  16. Talk From the VI Teachers' Lounge.

    ERIC Educational Resources Information Center

    Hurst, Judith

    Gathered from teachers around the country, this collection of teaching ideas and lesson plans is designed to provide teachers with activities and strategies for educating students with visual impairments. Tips and information are provided on: making tactile teddy bears; memory strategies; making tactile books; creating art kits; using magnifiers;…

  17. Seeking History: Teaching with Primary Sources in Grades 4-6.

    ERIC Educational Resources Information Center

    Edinger, Monica

    This book offers ideas about using primary sources to enhance students' understandings of history. It discusses the following resources, methods, and ideas: types of primary sources; tips on finding and preparing primary sources for student use; personal, local, and remote history activities; detailed descriptions of diverse projects; guidelines…

  18. Ideas and Activities for Physical Science.

    ERIC Educational Resources Information Center

    Chiappetta, Eugene L., Ed.

    This manual is designed to supplement an existing physical science curriculum and to assist in providing the learning experiences required to implement an effective course. The first chapter outlines the purposes of this manual and provides a set of teaching tips. Topics such as electricity, wave motion, light, sound, periodic table and nuclear…

  19. Rotation Conversation: A Tip on How To Organize a Conversation Class; Amazing Sentences of Indian Students: A Simple Writing Activity that Triggered Profound Ideas; "Short and Sweet" in a Thai Classroom (A Lesson Plan Based on a Mini Literacy Text); A Pile of Pictures: Ten Practical Ideas for Your Classroom.

    ERIC Educational Resources Information Center

    Singleton, Pat; Dhanavel, P.; Lwin, Phyu Phyu; Yoel, Judith

    2002-01-01

    Techniques for teaching in the English-as-a-Second/Foreign-Language classroom are included. They focus on planning a conversation class, teaching writing, a lesson plan based on a multiliteracy text, and how a pile of pictures can be used in different ways. (Author/VWL)

  20. Two for One: Using QAR to Increase Reading Comprehension and Improve Test Scores

    ERIC Educational Resources Information Center

    Green, Susan

    2016-01-01

    This teaching tip describes an intervention used in a third-grade classroom implemented to help students pass an end-of-grade reading comprehension test. Low scores on a practice end-of-grade comprehension test prompted a re-examination of classroom reading instruction and a plan for intervention. This teaching tip describes the phases implemented…

  1. Toilet Teaching Your Child

    MedlinePlus

    ... Safe Videos for Educators Search English Español Toilet Teaching Your Child KidsHealth / For Parents / Toilet Teaching Your ... to make the process easier. Tips for Toilet Teaching Even before your child is ready to try ...

  2. Health Rocks! Beginning Level. 4-H Healthy Life Series. Revised

    ERIC Educational Resources Information Center

    Fox, Marilyn

    2012-01-01

    Written for 8 to 12 year olds. The 21 activities use hands-on experience to facilitate youth learning, including concepts review and learning assessment at each chapter's end. A retrospective impact evaluation is included in the appendices along with additional resources, glossary, training outline and teaching tips. An accompanying cd-rom…

  3. Everyday TLC: Teaching, Learning, Caring, 2002.

    ERIC Educational Resources Information Center

    Durkin, Lisa L., Ed.; Miller, Sandy, Ed.

    2002-01-01

    This document is comprised of weekly newsletters for 2002, organized by month, for family child care providers. Each theme-based newsletter contains: (1) creative activities for use with mixed-age groups of 2- to 5-year-olds; (2) ideas on guiding behavior, organization tips, and a Monthly Planning Calendar; (3) special sections for infants and…

  4. Health Rocks! Intermediate Level. 4-H Healthy Life Series

    ERIC Educational Resources Information Center

    Fox, Marilyn

    2009-01-01

    Written for 12 to 14 year olds. The 25 activities use hands-on experience to facilitate youth learning, including concepts review and learning assessment at each chapter's end. A retrospective impact evaluation is included in the appendices along with additional resources, glossary, training outline and teaching tips. An accompanying cd-rom…

  5. Everyday TLC: Teaching, Learning, Caring, 2000.

    ERIC Educational Resources Information Center

    Durkin, Lisa L., Ed.

    2000-01-01

    This document is comprised of weekly newsletters for family child care providers for the year 2000. Each theme-based four-page newsletter contains: (1) creative activities for use with mixed-age groups of 2- to 5-year-olds; (2) ideas on guiding behavior, organization tips, and a Monthly Planning Calendar; (3) special sections for infants and…

  6. Everyday TLC: Teaching, Learning, Caring, 2003.

    ERIC Educational Resources Information Center

    Durkin, Lisa L., Ed.; Miller, Sandy, Ed.

    2003-01-01

    This document is comprised of weekly newsletters, compiled by month, for family child care providers for the year 2003. Each theme-based four-page newsletter contains: (1) creative activities for use with mixed-age groups of 2- to 5-year-olds; (2) ideas on guiding behavior, organization tips, and Monthly Planning Calendar; (3) special sections for…

  7. Yucca! Teaching the Essentials of a Wild Food Feast.

    ERIC Educational Resources Information Center

    Lamberton, Ken

    1994-01-01

    Using science from the classroom, a teacher involves students in variety of explorations to identify safe foods from outdoors. These activities culminate in a Wild Plant and Beast Feast day, where the students have an opportunity to share their new cuisine and recipes with classmates and teachers. Tips on the successful development and…

  8. William James's "Talks to Teachers" (1899) and McKeachie's "Teaching Tips" (1999)

    ERIC Educational Resources Information Center

    McKeachie, Wilbert J.

    2003-01-01

    What has changed and what has stayed the same in the years since the first publication of James's "Talks to Teachers on Psychology: And to Students on some of Life's Ideals" (1899) and the 10 editions of McKeachie's "Teaching Tips"? Although research and theory have given us better understanding of learning, memory, cognition, and motivation, much…

  9. Tell Me about Fred's Fat Foot Again: Four Tips for Successful PA Lessons

    ERIC Educational Resources Information Center

    Murray, Bruce A.

    2012-01-01

    This teaching tip applies research on phoneme awareness (PA) to propose an instructional model for teaching PA. Research suggests children need to learn the identifying features of phonemes to recognize them in spoken words. In the model, teachers focus on one phoneme at a time; make it memorable to children through sound analogies supported by…

  10. Teaching & Learning Tips 6: The flipped classroom.

    PubMed

    Shi, Connie R; Rana, Jasmine; Burgin, Susan

    2018-04-01

    Challenge: The "flipped classroom" is a pedagogical model in which instructional materials are delivered to learners outside of class, reserving class time for application of new principles with peers and instructors. Active learning has forever been an elusive ideal in medical education, but the flipped class model is relatively new to medical education. What is the evidence for the "flipped classroom," and how can these techniques be applied to the teaching of dermatology to trainees at all stages of their medical careers? © 2018 The International Society of Dermatology.

  11. A novel teaching system for industrial robots.

    PubMed

    Lin, Hsien-I; Lin, Yu-Hsiang

    2014-03-27

    The most important tool for controlling an industrial robotic arm is a teach pendant, which controls the robotic arm movement in work spaces and accomplishes teaching tasks. A good teaching tool should be easy to operate and can complete teaching tasks rapidly and effortlessly. In this study, a new teaching system is proposed for enabling users to operate robotic arms and accomplish teaching tasks easily. The proposed teaching system consists of the teach pen, optical markers on the pen, a motion capture system, and the pen tip estimation algorithm. With the marker positions captured by the motion capture system, the pose of the teach pen is accurately calculated by the pen tip algorithm and used to control the robot tool frame. In addition, Fitts' Law is adopted to verify the usefulness of this new system, and the results show that the system provides high accuracy, excellent operation performance, and a stable error rate. In addition, the system maintains superior performance, even when users work on platforms with different inclination angles.

  12. A Novel Teaching System for Industrial Robots

    PubMed Central

    Lin, Hsien-I; Lin, Yu-Hsiang

    2014-01-01

    The most important tool for controlling an industrial robotic arm is a teach pendant, which controls the robotic arm movement in work spaces and accomplishes teaching tasks. A good teaching tool should be easy to operate and can complete teaching tasks rapidly and effortlessly. In this study, a new teaching system is proposed for enabling users to operate robotic arms and accomplish teaching tasks easily. The proposed teaching system consists of the teach pen, optical markers on the pen, a motion capture system, and the pen tip estimation algorithm. With the marker positions captured by the motion capture system, the pose of the teach pen is accurately calculated by the pen tip algorithm and used to control the robot tool frame. In addition, Fitts' Law is adopted to verify the usefulness of this new system, and the results show that the system provides high accuracy, excellent operation performance, and a stable error rate. In addition, the system maintains superior performance, even when users work on platforms with different inclination angles. PMID:24681669

  13. Ten Fire Safety Tips for Schools.

    ERIC Educational Resources Information Center

    Lake, James D.

    1999-01-01

    Provides 10 basic tips, compiled from the National Fire Protection Association's Life Safety Code 101, to ensure that educational facilities are fire safe. Tips include use of frequent and unexpected fire drills, limiting wall space of student artwork and teaching materials, being alert to preventing arson, planning speedy and safe emergency…

  14. Teaching Concepts to Young Children Through Cultural Cooking Experiences. Bilingual/Bicultural Child Development Associate Pilot Project: Module XIV.

    ERIC Educational Resources Information Center

    Smith, Teresa R.

    This Child Development Associate (CDA) module, the fourteenth in a series of 16, suggests ways concepts can be taught by involving preschool children in carefully planned classroom cooking activities. Designed for bilingual/bicultural preschool teacher trainees, the module provides tips on food preparation as a learning experience. Required…

  15. Twelve Tips for teaching medical professionalism at all levels of medical education.

    PubMed

    Al-Eraky, Mohamed Mostafa

    2015-01-01

    Review of studies published in medical education journals over the last decade reveals that teaching medical professionalism is essential, yet challenging. According to a recent Best Evidence in Medical Education (BEME) guide, there is no consensus on a theoretical or practical model to integrate the teaching of professionalism into medical education. The aim of this article is to outline a practical manual for teaching professionalism at all levels of medical education. Drawing from research literature and author's experience, Twelve Tips are listed and organised in four clusters with relevance to (1) the context, (2) the teachers, (3) the curriculum, and (4) the networking. With a better understanding of the guiding educational principles for teaching medical professionalism, medical educators will be able to teach one of the most challenging constructs in medical education.

  16. Surgeon-authored Virtual Laparoscopic Adrenalectomy Module is Judged Effective and Preferred over Traditional Teaching Tools

    PubMed Central

    Kurenov, Sergei; Cendan, Juan; Dindar, Sahel; Attwood, Kristopher; Hassett, James; Nawotniak, Ruth; Cherr, Gregory; Cance, William G.; Peters, Jörg

    2018-01-01

    Objective The study assesses user acceptance and effectiveness of a surgeon-authored virtual reality training module authored by surgeons using the Toolkit for Illustration Procedures in Surgery (TIPS). Methods Laparoscopic adrenalectomy was selected to test the TIPS framework on an unusual and complex procedure. No commercial simulation module exists to teach this procedure. A specialist surgeon authored the module, including force-feedback interactive simulation and designed a quiz to test knowledge of the key procedural steps. Five practicing surgeons with 15 to 24 years of experience peer-reviewed and tested the module. Fourteen residents and nine fellows trained with the module and answered the quiz, pre-use and post-use. Participants received an overview during Surgical Grand Rounds session and a 20-minute one- on-one tutorial followed by a 30 minute of instruction in addition to a force-feedback interactive simulation session. Additionally, in answering questionnaires, the trainees reflected on their learning experience and their experience with the TIPS framework. Results Correct quiz response rates on procedural steps improved significantly post-use over pre-use. In the questionnaire, 96% of the respondents stated that the TIPS module prepares them well or very well for the adrenalectomy, and 87% indicated that the module successfully teaches the steps of the procedure. All subjects indicated that they preferred the module compare to training using purely physical props, one-on-one teaching, medical atlases, and video recordings. Conclusions Improved quiz scores and endorsement by the participants of the TIPS adrenalectomy module establish the viability of surgeons authoring virtual reality training. PMID:27758896

  17. Community Involvement in Law Education: Human Resources in Carroll County, Maryland. Law-Related Education Program for the Schools of Maryland.

    ERIC Educational Resources Information Center

    Vetter, Donald P.; Vigliotti, Mark A.

    Community resources, learning activities, teaching tips, field trip suggestions, and other sources available in Carroll County, Maryland, for use by K-12 teachers in developing, planning, and implementing citizenship education programs in the social studies classroom are provided. The first chapter examines procedures to be followed by teachers…

  18. A Review of Swimming Cues and Tips for Physical Education

    ERIC Educational Resources Information Center

    Higginson, Kelsey; Barney, David

    2016-01-01

    Swimming is a low-impact activity that causes little stress on joints so it can be done for a lifetime. Many teachers may wish to teach swimming but do not have cues or ideas for doing so. This article reviews swimming cues, relays and equipment that can help a physical education teacher include a swimming unit in their curriculum. Certification…

  19. Shall We Dance? A Guide for Teachers with Two Left Feet.

    ERIC Educational Resources Information Center

    Morris, Grace M.

    1996-01-01

    Educators who want to make movement a part of their teaching must teach students the basic steps that comprise movement. This involves expanding students' range of locomotion, teaching spatial relationships, and exploring different body shapes. Literature references for teaching movement, a list of resources, and six teaching tips are included.…

  20. Tutoring ESL: A Handbook for Volunteers.

    ERIC Educational Resources Information Center

    Tacoma Community House, WA.

    This handbook contains several different sections to aid volunteers teaching English-as-a-Second-Language (ESL) to refugees. Part 1, "Getting Started," discusses cultural differences and difficulties the students may encounter. Part 2, "Mechanics of Teaching," offers tips on teaching refugees and general teaching methods. Lesson planning,…

  1. Enhancing Leadership Quality. TQ Source Tips & Tools: Emerging Strategies to Enhance Educator Quality

    ERIC Educational Resources Information Center

    National Comprehensive Center for Teacher Quality, 2008

    2008-01-01

    Teaching Quality (TQ) Source Tips & Tools: Emerging Strategies to Enhance Educator Quality is an online resource developed by the TQ Center. It is designed to help education practitioners tap into strategies and resources they can use to enhance educator quality. This publication is based on the TQ Source Tips & Tools topic area "Enhancing…

  2. Teaching Elementary School Students to Be Effective Writers: Instructional Tips Based on the Educator's Practice Guide

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2017

    2017-01-01

    Instructional tips help educators carry out recommendations contained in IES Educator's Practice Guides. The tips, based on a practice guide authored by Steve Graham, Alisha Bollinger, Carol Booth Olson, Catherine D'Aoust, Charles MacArthur, Deborah McCutchen, and Natalie Olinghouse, translate these recommendations into actionable approaches that…

  3. A Design Thinking Approach to Teaching Knowledge Management

    ERIC Educational Resources Information Center

    Wang, Shouhong; Wang, Hai

    2008-01-01

    Pedagogies for knowledge management courses are still undeveloped. This Teaching Tip introduces a design thinking approach to teaching knowledge management. An induction model used to guide students' real-life projects for knowledge management is presented. (Contains 1 figure.)

  4. "One-Size-Does-Not-Fit-All": Teaching MBA Students Different ERP Implementation Strategies

    ERIC Educational Resources Information Center

    Venkatesh, Viswanath

    2008-01-01

    This teaching tip discusses an approach to educating MBA students regarding strategies to select, design, and implement enterprise resource planning (ERP) systems. The teaching approach presented here discusses how to teach students about different strategies based success stories from three different organizations, namely Cisco, Tektronix, and…

  5. Tips for Science Teachers Having Students with Disabilities.

    ERIC Educational Resources Information Center

    Keller, Ed C., Jr.

    This document highlights strategies for teaching science students with common learning disabilities. For each learning disability listed, there are sections on courtesy and several teaching methods with mitigative teaching strategies. Highlighted disabilities include Attention Deficit Disorder (ADD), Emotional Disabilities, Epilepsy, Hearing…

  6. Reading, Writing, and Word Walls: Strategies to Boost Literacy Skills in All Learners

    ERIC Educational Resources Information Center

    Campbell-Rush, Peggy

    2007-01-01

    In this book, author Peggy Campbell-Rush shares the strategies she relies on to teach young students not only how to read and write, but also to love to read and write. Teachers will find close to 100 tips, ideas, and activities that they can implement immediately, including: the dos and don'ts for reading aloud; putting new twists on tedious…

  7. Learning Skills of Peace through Every Day Conflicts: Practical Activities and Resources for Families, Teachers and Other Caregivers. [Loose-Leaf Pages and Pack of Cards].

    ERIC Educational Resources Information Center

    Ohio Commission on Dispute Resolution and Conflict Management, Columbus.

    Noting that the conflicts arising daily for young children provide an opportunity for adults to model and teach skills for handling conflict peacefully, this guide provides tips for preventing unnecessary conflict, offers "first aid" for conflict moments, and provides resources for addressing common situations that can cause conflict.…

  8. Teaching Elementary School Students to Be Effective Writers. Summary of Evidence for Instructional Tips Based on the Educator's Practice Guide

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2017

    2017-01-01

    Instructional tips help educators carry out recommendations contained in IES Educator's Practice Guides. This summary of evidence describes the research evidence that supports the use of the instructional tips in classrooms, and is based on a practice guide authored by Steve Graham, Alisha Bollinger, Carol Booth Olson, Catherine D'Aoust, Charles…

  9. How to conduct a workshop on medical writing: Tips, advice and experience sharing.

    PubMed

    Rathore, Farooq Azam; Mansoor, Sahibzada Nasir

    2015-06-01

    Medical writing has become an essential skill for anybody in academia and engaged in teaching. Workshops on medical writing are an effective way to teach the essential skills of medical writing to students and faculty members. There is a huge demand for these workshops all around the globe. Usually there is no curriculum of medical writing for the undergraduates or dedicated structured training sessions for the faculty members. One of the authors won an Author AID grant to conduct a series of workshops on medical writing. Eight workshops were conducted in three months, benefitting more than 200 students and faculty staff. We share our experience of holding this successful series of workshops with the aim that it might serve as a guide for researchers and faculty members who are eager to share and transfer their skills and knowledge. We also offer lessons learnt during this educational activity, tips to improve the quality and delivery of the content with limited resources and maximizing the impact. Experienced medical writers need to conduct these workshops to transfer their skills and to facilitate their colleagues and students to become better medical writers. Planning, rehearsal, motivation, resource management, good team work, audience analysis and feedback can make a workshop successful. Well prepared workshop content delivered in an interactive way with a variety of activities makes the workshop an engaging and interesting educational activity.

  10. Tips for Teaching Math to Elementary Students

    ERIC Educational Resources Information Center

    Scarpello, Gary

    2010-01-01

    Since most elementary school teachers do not hold a degree in mathematics, teaching math may be a daunting task for some. Following are a few techniques to help make teaching and learning math easier and less stressful. First, know that math is a difficult subject to teach--even for math teachers. The subject matter itself is challenging. Second,…

  11. Tips from the Classroom.

    ERIC Educational Resources Information Center

    Wilhelm, Kim Hughes; Leverett, Thomas; Barrett, Rob J.; Chur-Hansen, Anna; Dantas-Whitney, Maria; Zapata, Gabriela; Garcia, Juan Felix

    1998-01-01

    Five articles present tips for rallying English-as-a-Second-Language students to the enterprise of creating context, tools, and language itself. The articles focus on using original dramas created by students, teaching nonnative English-speaking medical students to comprehend their patients' colloquial language, conducting research with native…

  12. The Complete Step-by-Step Guide to Designing and Teaching Online Courses

    ERIC Educational Resources Information Center

    Thormann, Joan; Zimmerman, Isa Kaftal

    2012-01-01

    In this valuable resource, experts share deep knowledge including practical "how-to" and preventive trouble-shooting tips. Instructors will learn about course design and development, instructional methods for online teaching, and student engagement and community building techniques. The book contains successful teaching strategies, guidance for…

  13. Advertising and the Economy: A Teaching Package.

    ERIC Educational Resources Information Center

    Proctor and Gamble Co., Cincinnati, OH.

    This teaching packet is designed to enrich lessons and motivate students, and is based on real-life marketing problems. The packet includes a booklet containing background for instructors on advertising's crucial economic role and its history in the United States, eight reproducible lessons, and teaching tips for each lesson. The packet also…

  14. Pokémon GO: Implications for Literacy in the Classroom

    ERIC Educational Resources Information Center

    Howell, Emily

    2017-01-01

    This teaching tip gives teachers practical applications of the game Pokémon GO for literacy teaching and learning. The author discusses applications of the game for teaching multimodality in upper elementary-school classrooms. The author situates these applications in relevant theoretical perspectives as well as current literacy research.

  15. Life Skills Curriculum for Senior Adult Learners.

    ERIC Educational Resources Information Center

    Leon County Schools, Tallahassee, FL.

    This life skills curriculum helps adult basic educators meet the needs of senior adult learners. An introduction contains the following sections: purpose statement; description of the senior adult learner; tips to remember on teaching senior adults; physiology of aging; teaching the hearing impaired; and teaching the visually impaired. The life…

  16. Teaching About Nuclear Power: A Simulation.

    ERIC Educational Resources Information Center

    Maxey, Phyllis F.

    1980-01-01

    Recommends that simulation games be used to teach high school students in social studies courses about contemporary and controversial issues such as nuclear power. A simulation is described which involves students in deciding whether to build a nuclear power plant in the California desert. Teaching and debriefing tips are also provided. (DB)

  17. Gain attention, enhance memory, and improve learning with brain-based strategies.

    PubMed

    Restaino, Rusti

    2011-05-01

    Applying what we know about brain function to both traditional and online teaching is easy. This column discusses brain function and "tips" for structuring teaching based on it. Copyright 2011, SLACK Incorporated.

  18. Twelve tips for teaching child development and disability to medical students.

    PubMed

    McDonald, Jenny

    2018-02-01

    Child development is a marker of well-being in childhood and recognition of developmental delay allows timely investigation and intervention for children with developmental disabilities. Despite this, child development and disabilities are not given emphasis in the medical curriculum. This under representation of teaching combined with the stigma associated with disabilities contributes to the sub-optimal health care of people with disabilities. As well as, addressing the stigma of disability a medical undergraduate curriculum should include: the key concepts of child development; the clinical presentation of the most common developmental disabilities; developmental history taking and the infant neurodevelopmental examination. The following twelve tips provide practical advice about how to teach this knowledge and these skills during medical training.

  19. Teaching Students Who Stutter

    ERIC Educational Resources Information Center

    Education Digest: Essential Readings Condensed for Quick Review, 2011

    2011-01-01

    Stutterer's incident in class draws national attention; Stuttering Foundation responds with tips for educators. In response to the articles in the "New York Times," Jane Fraser, president of the nonprofit Stuttering Foundation, wrote in a press release eight tips for educators regarding working with students who stutter. This article presents…

  20. Thirty Simple Ideas for Interactive Whiteboards

    ERIC Educational Resources Information Center

    Adams, Caralee

    2011-01-01

    This article presents thirty simple ideas for interactive whiteboards and how IWB can make one's teaching life easier. These teaching ideas for the interactive whiteboard can be used by teachers every day. Tips for classroom management are also presented.

  1. Using Moos To Help Learn English; Video Jigsaw; Practicing Speaking with Follow-Up Interviews and Student-Read Dictations; "Ask the Expert": Oral Presentations that Work; The Medium Is the Message.

    ERIC Educational Resources Information Center

    Miller, James; Reynolds, Judith; Noble, P. C.; Altschuler, Lee; Schauber, Holli

    2001-01-01

    Four short articles provide teaching tips for the English-as-a-Second/Foreign-Language classroom, including the use of Moos, a video jigsaw, practicing oral language skills with interviews and student-read dictations, an ask the expert activity which builds learner confidence in speaking in front of groups of people. (Author/VWL)

  2. Teaching Balance with Tai Chi: Strategies for College and Secondary School Instruction.

    ERIC Educational Resources Information Center

    Chen, David D.; Sherman, Clay P.

    2002-01-01

    Examines the benefits of incorporating Tai Chi into the secondary and college curriculum to teach balance, discussing: the history and philosophical underpinnings of Tai Chi, principles of Tai Chi movement, health benefits, and teaching Tai Chi in public schools. Tips for instructors include: follow the principles of progression, follow a…

  3. Tips for Teaching.

    ERIC Educational Resources Information Center

    Langer, Philip

    1987-01-01

    Suggestions on how to enhance college teaching are provided. Lecturing is stressed as a critical component of teaching, and each lecture's introduction, main body, and conclusion must be correlated prior to any given lecture. Information on how to compose and give a lecture includes: what to put in an introduction; what can be done to help the…

  4. Creating a Winning Game Plan. The Secondary Teacher's Playbook.

    ERIC Educational Resources Information Center

    Gose, Michael D.

    This book offers strategies for high school teachers that provide tools for creating, repairing, and tweaking all the discernible components of teaching. The book is organized to move from context to teaching to discipline to thriving in teaching. The book includes tips on how to minimize discipline problems with effective curriculum and sound…

  5. Tips for Working with ADHD Students of All Ages.

    ERIC Educational Resources Information Center

    Robelia, Beth

    1997-01-01

    Tips for working with students who have attention deficit hyperactivity disorder include putting them in charge of something, providing structure, giving feedback, using logical consequences for unwanted behavior, being patient, teaching in novel ways, helping them with their gear, pairing them with another student, allowing blow-out time, and…

  6. Aquatics. NAGWS Guide. July 1979-July 1981. Tips and Techniques for Teachers and Coaches.

    ERIC Educational Resources Information Center

    Polvino, Geri, Ed.; And Others

    Articles covering a wide spectrum of aquatic sports are presented as aids to teachers and coaches of swimming. Included are suggestions for teaching swimming to the handicapped and infants, specific techniques for developing swimming skills, and tips for boating education and water safety. (JD)

  7. Twelve tips for applying the science of learning to health professions education.

    PubMed

    Gooding, H C; Mann, K; Armstrong, E

    2017-01-01

    Findings from the science of learning have clear implications for those responsible for teaching and curricular design. However, this data has been historically siloed from educators in practice, including those in health professions education. In this article, we aim to bring practical tips from the science of learning to health professions educators. We have chosen to organize the tips into six themes, highlighting strategies for 1) improving the processing of information, 2) promoting effortful learning for greater retention of knowledge over time, 3) applying learned information to new and varied contexts, 4) promoting the development of expertise, 5) harnessing the power of emotion for learning, and 6) teaching and learning in social contexts. We conclude with the importance of attending to metacognition in our learners and ourselves. Health professions education can be strengthened by incorporating these evidence-based techniques.

  8. "Una Luna Brilla."

    ERIC Educational Resources Information Center

    Teaching Music, 2002

    2002-01-01

    Focuses on the "World's Largest Concerts" listing various songs to be sung by students. Includes teaching tips in the form of quotes from music teachers on aspects of music education, such as teaching rhythm. Includes information on how to access the songs. (CMK)

  9. Applying an Experiential Learning Model to the Teaching of Gateway Strategy Board Games

    ERIC Educational Resources Information Center

    Sato, Aiko; de Haan, Jonathan

    2016-01-01

    The board game hobby has rapidly grown and evolved in recent years, but most of the non-digital games lack tips and tutorials and remain difficult to learn and teach effectively. In this project, we integrated a popular hobbyist approach to teaching modern strategy games with classical experiential learning elements (i.e., demonstration,…

  10. Using Design Thinking to Write and Publish Novel Teaching Cases: Tips from Experienced Case Authors

    ERIC Educational Resources Information Center

    Sheehan, Norman T.; Gujarathi, Mahendra R.; Jones, Joanne C.; Phillips, Fred

    2018-01-01

    With increasing calls for a greater connection between management education and practice, teaching cases play a vital role in the business curriculum. Cases not only allow instructors to expose students to practical problems but also let educators contribute to the scholarship of teaching and learning. An important reason why faculty members may…

  11. Developing the Psychologist's Credibility in Teaching First-Year Medical Students.

    ERIC Educational Resources Information Center

    1984

    Tips are offered for psychologists who teach behavioral science to first-year medical students, based on a course offered at Creighton Medical School. It is suggested that medical students will work hard and are interested in learning topics that will be useful. It is important for the psychology instructor to teach a body of knowledge to medical…

  12. Changing the Way You Teach, Improving the Way Students Learn

    ERIC Educational Resources Information Center

    Martin-Kniep, Giselle O.; Picone-Zocchia, Joanne

    2009-01-01

    Two experienced teacher educators describe a framework for effective teaching that can be applied in any subject area and grade level. Their detailed review of the structures, processes, and content of effective practice provides you with lots of practical tips you can use right away, including: (1) How to teach both the depth and the breadth of…

  13. Evolution of Advanced Learning Technologies in the 21st Century

    ERIC Educational Resources Information Center

    Graesser, Arthur C.

    2013-01-01

    The role of technology in education has mystified the contributors to "Theory Into Practice" ("TIP") during its 50-year history. In the first issue of "TIP," Guba (1962) was confident that "teaching machines are here to stay" and would help education, but raised various practical concerns, such as costs,…

  14. Twelve tips for using social media as a medical educator.

    PubMed

    Kind, Terry; Patel, Pradip D; Lie, Désirée; Chretien, Katherine C

    2014-04-01

    We now live, learn, teach and practice medicine in the digital era. Social networking sites are used by at least half of all adults. Engagement with social media can be personal, professional, or both, for health-related and educational purposes. Use is often public. Lapses in professionalism can have devastating consequences, but when used well social media can enhance the lives of and learning by health professionals and trainees, ultimately for public good. Both risks and opportunities abound for individuals who participate, and health professionals need tips to enhance use and avoid pitfalls in their use of social media and to uphold their professional values. This article draws upon current evidence, policies, and the authors' experiences to present best practice tips for health professions educators, trainees, and students to build a framework for navigating the digital world in a way that maintains and promotes professionalism. These practical tips help the newcomer to social media get started by identifying goals, establishing comfort, and connecting. Furthermore, users can ultimately successfully contribute, engage, learn, and teach, and model professional behaviors while navigating social media.

  15. Developing the teaching instinct, 1: feedback.

    PubMed

    Hesketh, E A; Laidlaw, J M

    2002-05-01

    The first in a new series of short educational programmes covering a range of important topics in medical education. Each programme defines the topic, provides some background information, presents some practical tips, gives some theoretical underpinning where relevant, provides some further reading and suggests an activity which can be carried out independently or with colleagues. The series has been designed in collaboration with NHS Education for Scotland as an aid to all engaged as trainers or teachers in the healthcare professions.

  16. Utility of a Systematic Approach to Teaching Photographic Nasal Analysis to Otolaryngology Residents.

    PubMed

    Robitschek, Jon; Dresner, Harley; Hilger, Peter

    2017-12-01

    Photographic nasal analysis constitutes a critical step along the path toward accurate diagnosis and precise surgical planning in rhinoplasty. The learned process by which one assesses photographs, analyzes relevant anatomical landmarks, and generates a global view of the nasal aesthetic is less widely described. To discern the common pitfalls in performing photographic nasal analysis and to quantify the utility of a systematic approach model in teaching photographic nasal analysis to otolaryngology residents. This prospective observational study included 20 participants from a university-based otolaryngology residency program. The control and intervention groups underwent baseline graded assessment of 3 patients. The intervention group received instruction on a systematic approach model for nasal analysis, and both groups underwent postintervention testing at 10 weeks. Data were collected from October 1, 2015, through June 1, 2016. A 10-minute, 11-slide presentation provided instruction on a systematic approach to nasal analysis to the intervention group. Graded photographic nasal analysis using a binary 18-point system. The 20 otolaryngology residents (15 men and 5 women; age range, 24-34 years) were adept at mentioning dorsal deviation and dorsal profile with focused descriptions of tip angle and contour. Areas commonly omitted by residents included verification of the Frankfort plane, position of the lower lateral crura, radix position, and ratio of the ala to tip lobule. The intervention group demonstrated immediate improvement after instruction on the teaching model, with the mean (SD) postintervention test score doubling compared with their baseline performance (7.5 [2.7] vs 10.3 [2.5]; P < .001). At 10 weeks after the intervention, the mean comparative improvement in overall graded nasal analysis was 17% (95% CI, 10%-23%; P < .001). Otolaryngology residents demonstrated proficiency at incorporating nasal deviation, tip angle, and dorsal profile contour into their nasal analysis. They often omitted verification of the Frankfort plane, position of lower lateral crura, radix depth, and ala-to-tip lobule ratio. Findings with this novel 10-minute teaching model should be validated at other teaching institutions, and the instruction model should be further enhanced to teach more sophisticated analysis to residents as they proceed through training. NA.

  17. Encouraging Student Participation While Designing Writing Exercises

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2017-12-01

    Encouraging student participation while designing writing exercises requires a certain pragmatic approach. Wilbert James McKeachie is the author of a widely read textbook on college teaching. McKeachie was a longtime faculty member at the University of Michigan. He served as president of the American Psychological Association, the American Psychological Foundation and the American Association of Higher Education. In his famous book Teaching and Learning in the College Classroom, McKeachie provides an introduction and notes the role of research in identifying new goals for higher education. He also offers a conceptual framework based on a student mediation model and a focuses on the processs-product relationships between faculty teacher behavior and student learning outcomes. McKeachie' s Teaching Tips provides helpful strategies for dealing with both the everyday problems of university teaching and those that arise in trying to maximize learning for every student. The book does not suggest a set of recipes to be followed mechanically; it gives instructors the tools they need to deal with the ever-changing dynamics of teaching and learning. First, it is extremely important to define the target skill areas and means of implementation. Next, the professor can then proceed to focus on the techniques that could be employed to ensure student participation. This includes selection of an appropriate topic that is relevant to the field of study as well as classroom learning experiences. By pragmatically combining these objectives, the teacher can expect both enthusiasm and effective learning among the student population. McKeachie, Wilbert James. (1980) Learning, Cognition and College Teaching. San Francisco: Jossey - Bass McKeachie, Wilbert James. (1980) Teaching Tips: A Guidebook for the Beginning College Teacher Lexington, MASS. : Heath. 1986. ISBN: 0669067520 McKeachie, Wilbert James., et. al. (2001) Teaching Tips (Eleventh Edition): Strategies, Research, and Theory for College and University Teachers by Houghton Mifflin Company. ISBN: 0618116494.

  18. Teaching Tips.

    ERIC Educational Resources Information Center

    Journalism Educator, 1981

    1981-01-01

    Four journalism teachers provide information on the use of tape recordings and written transcripts to illustrate the importance of factual accuracy, voluntary participation in a special advertising class, a method of teaching the history of public relations, and the importance of drill work to improve journalists' spelling abilities. (RL)

  19. Teaching Tips.

    ERIC Educational Resources Information Center

    Journalism Educator, 1985

    1985-01-01

    Presents a variety of journalism classroom techniques, including an editing scavenger hunt, a discovery method for compiling news sources, intense instruction in news technology, criteria for evaluating ad copy, a course combining print and broadcast journalism, use of the Teletext, and teaching ad forms for the new media. (HTH)

  20. Twelve tips on writing a discussion case that facilitates teaching and engages learners.

    PubMed

    Cohen, David A; Newman, Lori R; Fishman, Laurie N

    2017-02-01

    The authors share twelve practical tips on writing a case that engages learners in active learning and discussion. They first advise that, during the initial preparation of the case, authors should (1) identify the case goals and objectives, and (2) identify the level of the learners. When writing the case, authors should (3) use active and colorful language; (4) use patients' own descriptions rather than medical language; (5) allow the learners to interpret data themselves; (6) allow for natural discovery rather than presenting information chronologically; and (7) be realistic about interruptions in patient care. In addition, case authors should pay attention to methods that enhance discussion by (8) creating barriers to diagnostic or treatment options; (9) promoting questions and discussion over answers; (10) using cues to assure discussion flow and knowledge exploration; and (11) omitting details or inserting informational distractors. Finally, well-crafted questions are essential during the case presentation to engage learners in higher-order thinking; and to (12) stimulate curiosity and reflection.

  1. The Nitty-Gritty Classroom and Behavior Management Resource: Strategies, Reproducibles, and Tips for Teachers

    ERIC Educational Resources Information Center

    Tetteris, Belinda Christine

    2006-01-01

    This book will help teachers better relate to, understand, and love their job by providing a professional resource that contains innovative ideas, visuals, and reproducibles that can be referenced quickly to help make the job easier. This comprehensive resource offers practical teaching techniques, solutions, and tips on: (1) Planning and…

  2. The Nitty-Gritty Classroom and Behavior Management Resource: Strategies, Reproducibles, and Tips for Teachers

    ERIC Educational Resources Information Center

    Tetteris, Belinda Christine

    2006-01-01

    This book will help teachers better relate to, understand, and love their job. This is a professional resource that contains innovative ideas, visuals, and reproducibles that can be referenced quickly to help make the job easier. This comprehensive resource offers practical teaching techniques, solutions, and tips on: (1) Planning and designing…

  3. An Interactive Teddy Bear Clinic Tour: Teaching Veterinary Students How to Interact with Young Children.

    PubMed

    Dalley, Jessica S; Creary, Patricia R; Durzi, Tiffany; McMurtry, C Meghan

    Although there are existing guidelines for teaching and learning skillful client communication, there remains a need to integrate a developmental focus into veterinary medical curricula to prepare students for interactions with children who accompany their companion animals. The objectives of this teaching tip are (1) to describe the use of a Teddy Bear Clinic Tour as an innovative, applied practice method for teaching veterinary students about clinical communication with children, and (2) to provide accompanying resources to enable use of this method to teach clinical communication at other facilities. This paper includes practical guidelines for organizing a Teddy Bear Clinic Tour at training clinics or colleges of veterinary medicine; an anecdotal description of a pilot study at the Ontario Veterinary College Smith Lane Animal Hospital; and printable resources, including a list of specific clinical communication skills, a sample evaluation sheet for supervisors and students, recommendations for creating a child-friendly environment, examples of child-friendly veterinary vocabulary, and a sample script for a Teddy Bear Clinic Tour. Informed by the resources provided in this teaching tip paper, the Teddy Bear Clinic Tour can be used at your facility as a unique teaching method for clinical communication with children and as a community outreach program to advertise the services at the facility.

  4. Learning to Listen.

    ERIC Educational Resources Information Center

    Helgesen, Marc

    1998-01-01

    Discusses the importance of teaching English-as-a-Second-Language students to be effective listeners, examining different types of listening (listening for gist, listening for specific information, and inference) and describing how to determine the direction in which students listen (top down or bottom up). Two sidebars present teaching tips and…

  5. Recorder Resources, Part 2

    ERIC Educational Resources Information Center

    Marshall, Herbert D.; VanHaaren, Peg

    2006-01-01

    This article provides teaching tips and materials related to recorder lesson. Teaching Recorder in the Music Classroom, by Fred Kersten, compiles more current recorder information than any other resource. In planning instruction, the major determining factor seems to be Rote or Note. This allows instructors to take familiar repertoire that…

  6. Social Media Tips to Enhance Medical Education.

    PubMed

    Shah, Vikas; Kotsenas, Amy L

    2017-06-01

    In this article, we describe how social media can supplement traditional education, articulate the advantages and disadvantages of various social media platforms for both teachers and learners, discuss best practices to maintain confidentiality of protected health information, and provide tips for implementing social media-based teaching into the training curriculum. Copyright © 2017 The Association of University Radiologists. All rights reserved.

  7. Using Cascading Style Sheets to Design a Fly-Out Menu with Microsoft Visual Studio

    ERIC Educational Resources Information Center

    Liu, Chang; Downing, Charles

    2010-01-01

    The menu has become an integrated component within nearly all professionally designed websites. This teaching tip presents a no-code way to design either a vertical or a horizontal fly-out menu by using Cascading Style Sheets (CSS) within Microsoft Visual Studio 2008. The approach described in this tip helps students fully understand how to…

  8. Survival Guide for the First-Year Special Education Teacher. Revised Edition.

    ERIC Educational Resources Information Center

    Cohen, Mary Kemper; And Others

    This guidebook offers practical advice to support special education teachers in their first year of teaching. The first chapter, "Getting Ready To Teach," outlines preparations necessary before school begins, such as organizing the classroom and establishing planning and record-keeping strategies. "Tips for the Classroom" lists what teachers…

  9. Introducing Economics: A Critical Guide for Teaching

    ERIC Educational Resources Information Center

    Maier, Mark H.; Nelson, Julie A.

    2007-01-01

    Make economics resonate to high school students. This practical handbook will help economics and social studies teachers foster critical thinking by introducing students to the real-life dimensions of the major controversies in contemporary economics. Filled with useful teaching tips and user-friendly information on finding engaging materials and…

  10. Best Practices for High School Classrooms: What Award-Winning Secondary Teachers Do.

    ERIC Educational Resources Information Center

    Stone, Randi

    This book provides guidance on high-impact teaching practices, offering first-hand accounts of award-winning teachers. Nine chapters include: (1) "Award-Winning Words of Wisdom," with topics: "High School Teaching Tips" (Jenny W. Holmstrom); "What Is a Good Teacher?" (Carey Jenkins); "Student Creativity"…

  11. Tips on Teaching Writing.

    ERIC Educational Resources Information Center

    Today's Education, 1982

    1982-01-01

    Techniques for stirring students' interest in writing include: (1) exposing them to eloquent language use; (2) group poetry-writing (each student writes one line of a class poem); and (3) adapting why-and-because outlines intended for teaching college writing for use by younger students. Suggestions for obtaining writing quantity and quality are…

  12. Teaching with Distance Delivery Systems: Strategies from Alpha to Omega.

    ERIC Educational Resources Information Center

    Rezabek, Landra L.

    Distance education can assume many forms, including videotaped lectures, computer-mediated communication among teacher and student, and instantaneous, live two-way interaction. This paper focuses on tips and strategies for educators wishing to expand their teaching repertoires to include the use of these technologies. Teacher strategies listed…

  13. Teach Children Pedestrian Safety.

    ERIC Educational Resources Information Center

    Faber, Marilyn M.

    1997-01-01

    Provides advice on teaching children safe pedestrian and bicycling skills to reduce accidents caused by mistakes made in crossing streets. Provides an interactive safe-walker's story, tips for walking safely, step-by-step instructions for safe street crossing, bicycle safety information, a quiz for safe biking, and guidelines to ensure a proper…

  14. Using Multicultural Children's Literature to Teach Diverse Perspectives

    ERIC Educational Resources Information Center

    Iwai, Yuko

    2015-01-01

    As increasing numbers of students from diverse cultures are entering schools, educators need to include diversity in their teaching to promote diverse perspectives and help students become global citizens. The author offers tips for elementary teachers on using multicultural children's literature in their classrooms. Teachers are encouraged to…

  15. DNA-binding activity of TNF-{alpha} inducing protein from Helicobacter pylori

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kuzuhara, T.; Suganuma, M.; Oka, K.

    2007-11-03

    Tumor necrosis factor-{alpha} (TNF-{alpha}) inducing protein (Tip{alpha}) is a carcinogenic factor secreted from Helicobacter pylori (H. pylori), mediated through both enhanced expression of TNF-{alpha} and chemokine genes and activation of nuclear factor-{kappa}B. Since Tip{alpha} enters gastric cancer cells, the Tip{alpha} binding molecules in the cells should be investigated. The direct DNA-binding activity of Tip{alpha} was observed by pull down assay using single- and double-stranded genomic DNA cellulose. The surface plasmon resonance assay, indicating an association between Tip{alpha} and DNA, revealed that the affinity of Tip{alpha} for (dGdC)10 is 2400 times stronger than that of del-Tip{alpha}, an inactive Tip{alpha}. This suggestsmore » a strong correlation between DNA-binding activity and carcinogenic activity of Tip{alpha}. And the DNA-binding activity of Tip{alpha} was first demonstrated with a molecule secreted from H. pylori.« less

  16. Tensions of Teaching: Beyond Tips to Critical Reflection.

    ERIC Educational Resources Information Center

    Newman, Judith M.; And Others

    This book presents a collection of essays by educational practitioners who reflect on the tensions of teaching and show that ongoing critical reflection is a powerful means through which teachers can transform their beliefs and practices. The essays are the culmination of these educators' inquiries into their own practice. Part 1,…

  17. Survival Guide for the First-Year Special Education Teacher.

    ERIC Educational Resources Information Center

    Carballo, Julie Berchtold; And Others

    This book offers guidelines to support beginning special education teachers in their first year of teaching. "Getting Ready To Teach" covers things to do before school begins, such as organizing the classroom and establishing planning and record-keeping strategies. "Tips for the Classroom" focuses on surviving the first day, establishing classroom…

  18. 'Tween Crayons and Curfews: Tips for Middle School Teachers

    ERIC Educational Resources Information Center

    Wolpert-Gawron, Heather

    2011-01-01

    Teach well. Be happy. In this book, Heather Wolpert-Gawron, author of the popular education blog "Tweenteacher" shares ideas for teaching an age group that too often presents a challenge for educators. With sparkling humor and a unique, fundamental understanding of the middle children of education, the award-winning teacher offers tried-and-true…

  19. Hand-Clap Songs across the Curriculum

    ERIC Educational Resources Information Center

    Batchelor, Katherine E.; Bintz, William P.

    2012-01-01

    This teaching tip focuses on using hand-clapping to teach content area material across the curriculum. We begin with a brief history of hand-clap songs, followed by a rationale for using them in content area literacy. Then, we describe the instructional lesson, share samples that resulted, and discuss lesson extensions. Our goal is to have…

  20. A Dozen Teaching Tips for Diverse Classrooms

    ERIC Educational Resources Information Center

    Fogg, Piper

    2007-01-01

    For the majority of community-college professors, teaching is the most important part of their jobs, and it is not easy. Community-college students are a diverse bunch, but often face a particular set of challenges. Many entering students are not prepared for college-level work. While some students plan to transfer to competitive four-year…

  1. Moving Every Child Ahead: The Big6 Success Strategy.

    ERIC Educational Resources Information Center

    Berkowitz, Bob; Serim, Ferdi

    2002-01-01

    Explains the Big6 approach to teaching information skills and describes its use in a high school social studies class to improve student test scores, teach them how to learn, and improve the teachers' skills. Highlights include the balance between content and process, formative and summative evaluation, assignment organizers, and study tips. (LRW)

  2. Resource Kit Tips for Teaching Textiles and Clothing.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Continuing Education Curriculum Development.

    This kit has been designed to acquaint the instructor of adult textiles and clothing programs with some of the teaching aids that might be used to improve the learning process. The main parts of the publication include: Preparing and Using Transparencies; Developing a Learning Experience Using a Transparency; A Master Transparency with Overlays;…

  3. Teaching Introductory Psychology: Tips from "ToP"

    ERIC Educational Resources Information Center

    Griggs, Richard A., Ed.; Jackson, Sherri L., Ed.

    2011-01-01

    This book follows in the footsteps of the first three volumes in the "Handbook for Teaching Introductory Psychology" series. In the prefaces to these volumes, the various editors all stressed two major points relevant to the development of this series. These comments also apply to this book. First, introductory psychology is one of the most…

  4. Strategies for Teaching and Testing Communicative Competence in Russian.

    ERIC Educational Resources Information Center

    Dunatov, Rasio, Ed.

    This volume contains six workshop papers, each of which deals with one or more aspects of communicative competence. These papers are primarily reports of certain techniques which have been found successful for teaching and testing the ability to communicate in a foreign language. "Communicative Competence: Safety Tips for Riders on the Latest…

  5. Tips for Teachers: Lesson Plans and Ideas from around the World.

    ERIC Educational Resources Information Center

    Mathieson, Murray; And Others

    1990-01-01

    The following ideas are presented: (1) working together in calculus, including a handout for a jigsaw lesson; (2) a lesson on water and ecology from the USSR using the collective teaching technique; (3) the Israeli Havruta "Companionship" method for peer teaching; and (4) an origami lesson outlined and illustrated. (JD)

  6. Innovative Teaching Ideas. A Sharing of Teaching Tips, Ideas and Methods.

    ERIC Educational Resources Information Center

    Tenney, Richard W., Ed.; And Others

    Compiled from materials collected from 150 teachers of agriculture across New York State who participated in a series of 11 regional agriculture inservice workshops, this resource guide contains innovative techniques for classroom operation as well as suggestions for using available resources. The ideas have been organized into the following eight…

  7. Teaching Tip: Developing an Intercollegiate Twitter Forum to Improve Student Exam Study and Digital Professionalism.

    PubMed

    Whiting, Martin; Kinnison, Tierney; Mossop, Liz

    #VetFinals has been developed as a novel online Twitter teaching event designed to support intercollegiate veterinary teaching using social media. Previous studies in other fields have suggested that Twitter use within universities may have benefits for undergraduate education. This "teaching tip" paper describes a project using Twitter to host online exam study sessions. The project has been a highly successful collaborative effort between the Royal Veterinary College and Nottingham Veterinary School in the UK. Over 4 years, the #VetFinals project has developed into a long-term, self-sustaining enterprise. This initiative provides a semi-structured means for student exam preparation with direct real-time input from a faculty member. It also creates a network of peers both horizontally across institutions and vertically throughout year groups. Based on similar initiatives in other disciplines, an anticipated outcome of this project was to contribute to student online professionalism. This could help address the veterinary community's recently highlighted problems with professional conduct and appropriate use of social media. Analysis of the success of this endeavor will be available in a future publication.

  8. Teaching and Learning with Butterflies.

    ERIC Educational Resources Information Center

    Weisberg, Saul

    1996-01-01

    Presents butterflies as an introduction to natural history. Describes observation tips and metamorphosis of butterflies in the classroom. Includes butterfly resources for naturalists and educators. (AIM)

  9. "Teaching" an Industrial Robot To Spray

    NASA Technical Reports Server (NTRS)

    Evans, A. R.; Sweet, G. K.

    1982-01-01

    Teaching device, consisting of spacer rod or tube with three-pointed tip and line level, is used during pattern "teach-in" to make sure that robot manipulator holds spray gun perpendicular to surface to be sprayed and at right distance from it. For slanted surfaces angle adapter is added between spacer rod and line-level indicator. Angle is determined by slope of surface to be sprayed, thus allowing a perpendicular spray pattern against even slanted surfaces.

  10. The Power of Reflective Professional Development in Changing Elementary School Teachers' Instructional Practices

    NASA Astrophysics Data System (ADS)

    Cavedon, Carolina Christmann

    With the new goal of K-12 education being to prepare students to be college and career ready at the end of high school, education needs to start changing at the elementary school level. The literature suggests that teachers need reflective professional development (PD) to effectively teach to the new standards and to demonstrate change to their current instructional practices. This mixed-method multiple-case study investigated the impacts of a reflective professional development (PD) in changing elementary school teachers' instructional practices. Teachers Instructional Portfolios (TIPs) were scored with a TIP rubric based on best practices in teaching mathematics problem-solving and science inquiry. The TIPs were also analyzed with a qualitative coding scheme. Case descriptions were written and all the collected data were used to explain the impacts of the reflective PD on changes in teachers' instructional practices. While we found no predictive patterns in relation to teachers changing their classroom practices based on the reflective PD, we claim that teachers' desire to change might contribute to improvements in instruction. We also observed that teachers' self-assessment scores tend to be higher than the actual TIP scores corroborating with the literature on the usage of self-assessment to evaluate teachers' instructional practices.

  11. TIPS: Crime Resistance Strategies, 2. Teaching Individuals Protective Strategies, Teaching Individuals Positive Solutions.

    ERIC Educational Resources Information Center

    Bass, Martha; And Others

    This curriculum guide is the second-grade component of a teacher-developed K-eighth grade program on crime resistance. Major objectives of the program are to help teachers promote and maintain positive student attitudes and behavior, assist students in meeting their responsibilities, and help students insure their own and other people's safety and…

  12. TIPS: Crime Resistance Strategies, 1. Teaching Individuals Protective Strategies, Teaching Individuals Positive Solutions.

    ERIC Educational Resources Information Center

    Bass, Martha; And Others

    This document is the first-grade component of a K-eighth grade program on crime resistance. Major objectives of the program are to help teachers develop and implement a curriculum which promotes and maintains positive student attitudes and behavior, assists students in meeting their responsibilities, and helps students insure their own and other…

  13. TIPS: Crime Resistance Strategies, 3. Teaching Individuals Protective Strategies, Teaching Individuals Positive Solutions.

    ERIC Educational Resources Information Center

    Bass, Martha; And Others

    Emphasis in this third-grade component of a teacher-developed K-eighth grade program on crime resistance is on responsibility for personal behavior. Major objectives of the program are to help teachers promote and maintain positive student attitudes and behavior, assist students in meeting their responsibilities, and help students insure their own…

  14. The Path to Presidency: Tips for Teaching Elementary Students about the Election Process

    ERIC Educational Resources Information Center

    Conrad, Marika

    2016-01-01

    Teaching about presidential elections at the elementary level can seem a bit daunting at times. Students are quick to share their strong opinions on the current candidates running for office. These opinions often involve repeating feelings and phrases shared by parents around the dinner table the night before. For the average seven- or…

  15. Educating Adult Learners: Twelve Tips for Teaching Business Professionals. Reflection on Theory and Practice

    ERIC Educational Resources Information Center

    Kisamore, Jennifer L.; Aldridge, Dayle; Alexander, Evangeline; White, Dana Leann

    2008-01-01

    The goal of this paper is to provide specific suggestions for teaching adult business professionals. The suggestions we present are based on our combined experiences as instructors of business professionals who have returned to school for continuing education and as adult learners ourselves. In this article, we discuss the unique characteristics…

  16. The Caring Teacher: Tips to Motivate Student Learning

    ERIC Educational Resources Information Center

    Johnson, L. Peter

    2008-01-01

    The most successful educators know that there are two components to teaching: the academic side and the human side. Contrary to what most people think, the human aspect of teaching is by far the most difficult to achieve. Teachers are expected to relate to and educate a wide range of personalities, levels of maturity, and emotions. It is very…

  17. Substitute Your Way to a Real Job

    ERIC Educational Resources Information Center

    Stephens, Cathy

    2013-01-01

    For some, substitute teaching is a career choice. However, for the majority of new teachers, it is often a necessary gateway to landing a first job. Either way, it is a great way to sharpen one's skills. This article presents tips from principals, teachers, and human resource directors to make the most of the substitute teaching experience…

  18. "Elementary, My Dear Shakespeare." Producing a Shakespearean Festival in the Elementary Schools.

    ERIC Educational Resources Information Center

    Engen, Barbara; Campbell, Joy

    Intended to give teachers usable information and prepared materials that are ready-to-reproduce for students, this book compiles research, tips, and teaching ideas into a sourcebook on teaching and producing William Shakespeare's plays in the elementary classroom. It is designed to bring the student into an awareness of Shakespeare's art and…

  19. Teaching Web Search Skills: Techniques and Strategies of Top Trainers

    ERIC Educational Resources Information Center

    Notess, Greg R.

    2006-01-01

    Here is a unique and practical reference for anyone who teaches Web searching. Greg Notess shares his own techniques and strategies along with expert tips and advice from a virtual "who's who" of Web search training: Joe Barker, Paul Barron, Phil Bradley, John Ferguson, Alice Fulbright, Ran Hock, Jeff Humphrey, Diane Kovacs, Gary Price, Danny…

  20. A bibliography of articles of interest to teachers of psychology appearing in psychological reports 1955-2010.

    PubMed

    Abramson, Charles I; Curb, Lisa A; Barber, Kelsey R

    2011-02-01

    Abibliography is presented of articles related to various aspects of the teaching of psychology that have appeared in Psychological Reports from 1955-2010. The 605 articles are classified into 21 sections including those devoted to history, psychology of the scientist, teaching tips, textbook evaluation, and evaluation of students and professors.

  1. Tips, Tricks & Techniques: Creating & Teaching with Simple Animation: Making Biology Instruction Come Alive

    ERIC Educational Resources Information Center

    Zanin, Mary K. B.

    2015-01-01

    Over the years, many of my students have reported that they enjoy lectures that include short, simple animations. To keep students engaged, I have developed a small set of teaching animations using PowerPoint and Camtasia Studio software packages. A survey of students who learned four difficult topics with traditional written lessons and with…

  2. Control of the Water Transport Activity of Barley HvTIP3;1 Specifically Expressed in Seeds.

    PubMed

    Utsugi, Shigeko; Shibasaka, Mineo; Maekawa, Masahiko; Katsuhara, Maki

    2015-09-01

    Tonoplast intrinsic proteins (TIPs) are involved in the transport and storage of water, and control intracellular osmotic pressure by transporting material related to the water potential of cells. In the present study, we focused on HvTIP3;1 during the periods of seed development and desiccation in barley. HvTIP3;1 was specifically expressed in seeds. An immunochemical analysis showed that HvTIP3;1 strongly accumulated in the aleurone layers and outer layers of barley seeds. The water transport activities of HvTIP3;1 and HvTIP1;2, which also accumulated in seeds, were measured in the heterologous expression system of Xenopus oocytes. When they were expressed individually, HvTIP1;2 transported water, whereas HvTIP3;1 did not. However, HvTIP3;1 exhibited water transport activity when co-expressed with HvTIP1;2 in oocytes, and this activity was higher than when HvTIP1;2 was expressed alone. This is the first report to demonstrate that the water permeability of a TIP aquaporin was activated when co-expressed with another TIP. The split-yellow fluorescent protein (YFP) system in onion cells revealed that HvTIP3;1 interacted with HvTIP1;2 to form a heterotetramer in plants. These results suggest that HvTIP3;1 functions as an active water channel to regulate water movement through tissues during the periods of seed development and desiccation. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  3. Twelve tips for just in time teaching of communication skills for difficult conversations in the clinical setting.

    PubMed

    Hinkle, Laura Jean; Fettig, Lyle Patrick; Carlos, William Graham; Bosslet, Gabriel

    2017-09-01

    The ability to communicate well with patients and other members of the healthcare team is a vital skill for physicians to have, but one that is often not emphasized in medical education. Learners of all levels can obtain and develop good communication skills regardless of their natural ability in this area, and the clinical setting represents an underutilized resource to accomplish this task. With this in mind, we have reviewed the growing body of literature on the subject and organized our findings into twelve tips to help educators capitalize on these missed opportunities. While our emphasis is helping learners with difficult discussions, these tips can be easily adapted to any other clinical encounter requiring clear communication. Teaching effective communication skills in the clinical setting requires some extra time, but the steps outlined should not take more than a few minutes to complete. Taking the time to develop these skills in our learners will make a significant difference not only their lives but also their patients and their families.

  4. Reviews

    NASA Astrophysics Data System (ADS)

    2005-11-01

    WE RECOMMEND Joule and Watt Meter This versatile tool is aimed at low-voltage DC devices. Wireless datalogger Bluetooth enables data to be downloaded to your computer. WORTH A LOOK Amusement Park Physics This handbook contains teaching materials to excite students. Copper in the Curriculum Two free CDs cover aspects of Key Stages 3, 4 and 5. Launchpad A kit for making 25 devices that fire ping-pong balls. Solar water-heating kit This kit provides a good introduction to green energy. Solar voltaic cell The unit is ideal for Key Stages 1, 2 and 3. Wind turbine kit An impressive turbine that has many educational uses. HANDLE WITH CARE Hurdles and Strategies in the Teaching of Algebra A collection of tips that is really just for maths teachers. WEB WATCH A wealth of resources on the Internet support physics activities for students at amusement parks.

  5. Twelve tips for use of a white board in clinical teaching: reviving the chalk talk.

    PubMed

    Orlander, Jay D

    2007-03-01

    Little has been written on the art of using a board in clinical teaching. The technological development of the white board appears to have coincided with that of the laptop computer and accompanying LCD projector, so that fewer and fewer teaching sessions appear to utilize the board as an efficient teaching tool. I have observed this most commonly among younger faculty who are most comfortable with technology and who may lack training and experience with a blank board. This paper offers suggestions on using the board in clinical teaching in order to enhance the educational process through better engagement of the learners.

  6. Inside France: Three Missing Pages from Your Students' Textbook.

    ERIC Educational Resources Information Center

    Conniffe, Patricia, Ed.

    This mini-unit seeks to fill the gap in textbooks that exists when teaching about modern France. Many textbooks end their coverage of France with the chapter on World War II. This unit offers high school students a unique introduction to France in the mid-1990s. The mini-unit includes a two-sided poster, teaching tips, and student pages. Student…

  7. Teaching Outside the Box: How to Grab Your Students by Their Brains, 2nd Edition

    ERIC Educational Resources Information Center

    Johnson, LouAnne

    2011-01-01

    This second edition of the bestselling book includes practical suggestions for arranging your classroom, talking to students, avoiding the misbehavior cycle, and making your school a place where students learn and teachers teach. The book also contains enlivening Q&A from teachers, letters from students, and tips for grading. This new edition has…

  8. CFC (Comment-First-Coding)--A Simple yet Effective Method for Teaching Programming to Information Systems Students

    ERIC Educational Resources Information Center

    Sengupta, Arijit

    2009-01-01

    Programming courses have always been a difficult part of an Information Systems curriculum. While we do not train Information Systems students to be developers, understanding how to build a system always gives students an added perspective to improve their system design and analysis skills. This teaching tip presents CFC (Comment-First-Coding)--a…

  9. Lesson Closure: An Important Piece of the Student Learning Puzzle

    ERIC Educational Resources Information Center

    Ganske, Kathy

    2017-01-01

    As we seek ways to improve literacy teaching and learning, we need to be careful not to overlook lesson closure as an opportunity to solidify student learning. This Teaching Tip describes the importance of taking time at the ends of lessons, days, and weeks to revisit what students have learned as a means for helping them synthesize and assimilate…

  10. Focus issue: teaching tools and learning opportunities.

    PubMed

    Gough, Nancy R

    2010-04-27

    Science Signaling provides authoring experience for students and resources for educators. Students experience the writing and revision process involved in authoring short commentary articles that are published in the Journal Club section. By publishing peer-reviewed teaching materials, Science Signaling provides instructors with feedback that improves their materials and an outlet to share their tips and techniques and digital resources with other teachers.

  11. Twelve tips for creating an academic teaching portfolio.

    PubMed

    Little-Wienert, Kim; Mazziotti, Mark

    2018-01-01

    An academic teaching portfolio is not only a requirement at many academic teaching institutions, but it is also important in a medical educator's growth and development through documentation, reflection, evaluation, and change. Creating an academic portfolio may appear daunting at first but with careful advanced preparation, organized evidence collection of your educational work, proof of scholarship, and thorough documentation of self-reflection and change, you can produce a successful product that accurately represents your educational beliefs, accomplishments, and growth throughout your career. This article provides medical educators with twelve steps for creating a successful academic teaching portfolio.

  12. Lessons learned from the restaurant industry: what outstanding waiters and waitresses can teach the medical profession.

    PubMed

    Baum, Neil H; Segal, Jeff J

    2014-01-01

    All doctors and office staff go to restaurants and have men and women take our orders and deliver our food. These waiters and waitresses earn minimum wage and depend on tips for their income. Some of the best waiters and waitresses earn substantial incomes. This article will discuss the techniques used by stellar waiters and waitresses to generate more tips and how these techniques might apply to the healthcare profession.

  13. Reviews.

    ERIC Educational Resources Information Center

    Science Teacher, 1987

    1987-01-01

    Provides reviews of four computer software packages designed for use in science education. Describes courseware dealing with a variety of tips for teaching physics concepts, chemical reactions in an aqueous solution, mitosis and meiosis, and photosynthesis. (TW)

  14. Evaluation of the tip-bending response in clinically used endoscopes.

    PubMed

    Rozeboom, Esther D; Reilink, Rob; Schwartz, Matthijs P; Fockens, Paul; Broeders, Ivo A M J

    2016-04-01

    Endoscopic interventions require accurate and precise control of the endoscope tip. The endoscope tip response depends on a cable pulling system, which is known to deliver a significantly nonlinear response that eventually reduces control. It is unknown whether the current technique of endoscope tip control is adequate for a future of high precision procedures, steerable accessories, and add-on robotics. The aim of this study was to determine the status of the tip response of endoscopes used in clinical practice. We evaluated 20 flexible colonoscopes and five gastroscopes, used in the endoscopy departments of a Dutch university hospital and two Dutch teaching hospitals, in a bench top setup. First, maximal tip bending was determined manually. Next, the endoscope navigation wheels were rotated individually in a motor setup. Tip angulation was recorded with a USB camera. Cable slackness was derived from the resulting hysteresis plot. Only two of the 20 colonoscopes (10 %) and none of the five gastroscopes reached the maximal tip angulation specified by the manufacturer. Four colonoscopes (20 %) and none of the gastroscopes demonstrated the recommended cable tension. Eight colonoscopes (40 %) had undergone a maintenance check 1 month before the measurements were made. The tip responses of these eight colonoscopies did not differ significantly from the tip responses of the other colonoscopes. This study suggests that the majority of clinically used endoscopes are not optimally tuned to reach maximal bending angles and demonstrate adequate tip responses. We suggest a brief check before procedures to predict difficulties with bending angles and tip responses.

  15. Evaluation of the tip-bending response in clinically used endoscopes

    PubMed Central

    Rozeboom, Esther D.; Reilink, Rob; Schwartz, Matthijs P.; Fockens, Paul; Broeders, Ivo A. M. J.

    2016-01-01

    Background and study aims: Endoscopic interventions require accurate and precise control of the endoscope tip. The endoscope tip response depends on a cable pulling system, which is known to deliver a significantly nonlinear response that eventually reduces control. It is unknown whether the current technique of endoscope tip control is adequate for a future of high precision procedures, steerable accessories, and add-on robotics. The aim of this study was to determine the status of the tip response of endoscopes used in clinical practice. Materials and methods: We evaluated 20 flexible colonoscopes and five gastroscopes, used in the endoscopy departments of a Dutch university hospital and two Dutch teaching hospitals, in a bench top setup. First, maximal tip bending was determined manually. Next, the endoscope navigation wheels were rotated individually in a motor setup. Tip angulation was recorded with a USB camera. Cable slackness was derived from the resulting hysteresis plot. Results: Only two of the 20 colonoscopes (10 %) and none of the five gastroscopes reached the maximal tip angulation specified by the manufacturer. Four colonoscopes (20 %) and none of the gastroscopes demonstrated the recommended cable tension. Eight colonoscopes (40 %) had undergone a maintenance check 1 month before the measurements were made. The tip responses of these eight colonoscopies did not differ significantly from the tip responses of the other colonoscopes. Conclusion: This study suggests that the majority of clinically used endoscopes are not optimally tuned to reach maximal bending angles and demonstrate adequate tip responses. We suggest a brief check before procedures to predict difficulties with bending angles and tip responses. PMID:27092330

  16. Ten Tips for Engaging the Millennial Learner and Moving an Emergency Medicine Residency Curriculum into the 21st Century

    PubMed Central

    Toohey, Shannon L.; Wray, Alisa; Wiechmann, Warren; Lin, Michelle; Boysen-Osborn, Megan

    2016-01-01

    Introduction Millennial learners are changing the face of residency education because they place emphasis on technology with new styles and means of learning. While research on the most effective way to teach the millennial learner is lacking, programs should consider incorporating educational theories and multimedia design principles to update the curriculum for these new learners. The purpose of the study is to discuss strategies for updating an emergency medicine (EM) residency program’s curriculum to accommodate the modern learner. Discussion These 10 tips provide detailed examples and approaches to incorporate technology and learning theories into an EM curriculum to potentially enhance learning and engagement by residents. Conclusion While it is unclear whether technologies actually promote or enhance learning, millennials use these technologies. Identifying best practice, grounded by theory and active learning principles, may help learners receive quality, high-yield education. Future studies will need to evaluate the efficacy of these techniques to fully delineate best practices. PMID:27330668

  17. Ten Tips for Engaging the Millennial Learner and Moving an Emergency Medicine Residency Curriculum into the 21st Century.

    PubMed

    Toohey, Shannon L; Wray, Alisa; Wiechmann, Warren; Lin, Michelle; Boysen-Osborn, Megan

    2016-05-01

    Millennial learners are changing the face of residency education because they place emphasis on technology with new styles and means of learning. While research on the most effective way to teach the millennial learner is lacking, programs should consider incorporating educational theories and multimedia design principles to update the curriculum for these new learners. The purpose of the study is to discuss strategies for updating an emergency medicine (EM) residency program's curriculum to accommodate the modern learner. These 10 tips provide detailed examples and approaches to incorporate technology and learning theories into an EM curriculum to potentially enhance learning and engagement by residents. While it is unclear whether technologies actually promote or enhance learning, millennials use these technologies. Identifying best practice, grounded by theory and active learning principles, may help learners receive quality, high-yield education. Future studies will need to evaluate the efficacy of these techniques to fully delineate best practices.

  18. Start a Summer Arts Program.

    ERIC Educational Resources Information Center

    Pedersen, Kirie

    1984-01-01

    Tips on organizing a creative teaching experience for summer vacation time are offered. Program organization, student selection, course content, publicity, and funding are aspects to be considered when planning a summer arts program. (DF)

  19. Information for Librarians and Trainers

    MedlinePlus

    ... this page: https://medlineplus.gov/training/trainers.html Information for Librarians and Trainers To use the sharing ... Tips Resources for Teaching How to Find Health Information Online General Evaluating Internet Health Information: A Tutorial ...

  20. Hands-On English: A Periodical for Teachers and Tutors of Adult English as a Second Language, 1999-2000.

    ERIC Educational Resources Information Center

    Silliman, Anna, Ed.

    1999-01-01

    This periodical is a source of practical teaching advice for adult English-as-a-Second-Language (ESL) teachers and tutors since 1991. Articles and ideas are contributed by the experienced teachers and tutors among the readership. Among the topics covered in this volume are the following: tips on teaching older students, preparing students for the…

  1. O Say, They Can Sing! Teachers Share Their Tips for Teaching the National Anthem

    ERIC Educational Resources Information Center

    Preston, Teresa K.

    2004-01-01

    Teachers who have made "The Star-Spangled Banner" a central part of their students' repertoire have found that students can learn it and take pride in staging this familiar song that even their parents consider too difficult. Many teachers recognize that the first obstacle in teaching the anthem is that students do not know the words or understand…

  2. Real People Don't Do Boolean: How To Teach End Users To Find High-Quality Information on the Internet.

    ERIC Educational Resources Information Center

    Vine, Rita

    2001-01-01

    Explains how to train users in effective Web searching. Discusses challenges of teaching Web information retrieval; a framework for information searching; choosing the right search tools for users; the seven-step lesson planning process; tips for delivering group Internet training; and things that help people work faster and smarter on the Web.…

  3. Teaching Is an Art: An A-Z Handbook for Successful Teaching in Middle Schools and High Schools.

    ERIC Educational Resources Information Center

    Spreyer, Leon

    This book provides teachers with practical information for managing their work both in and out of the classroom. Highlights include advice on more than 80 subjects, book suggestions and games for the classroom, suggestions to help veteran teachers stay motivated and avoid burnout, and tips for new teachers on the first day and first week of school…

  4. Optimization of an Active Twist Rotor Blade Planform for Improved Active Response and Forward Flight Performance

    NASA Technical Reports Server (NTRS)

    Sekula, Martin K; Wilbur, Matthew L.

    2014-01-01

    A study was conducted to identify the optimum blade tip planform for a model-scale active twist rotor. The analysis identified blade tip design traits which simultaneously reduce rotor power of an unactuated rotor while leveraging aeromechanical couplings to tailor the active response of the blade. Optimizing the blade tip planform for minimum rotor power in forward flight provided a 5 percent improvement in performance compared to a rectangular blade tip, but reduced the vibration control authority of active twist actuation by 75 percent. Optimizing for maximum blade twist response increased the vibration control authority by 50 percent compared to the rectangular blade tip, with little effect on performance. Combined response and power optimization resulted in a blade tip design which provided similar vibration control authority to the rectangular blade tip, but with a 3.4 percent improvement in rotor performance in forward flight.

  5. Using Games to Teach Astronomy

    NASA Astrophysics Data System (ADS)

    Francis, Paul J.

    We all know that astronomical research is a chaotic sociable deeply human enterprise full of baffling mysteries enigmatic clues and breathtakingly unexpected conclusions. Abundant evidence suggests that our students see astronomy very differently. They see it as a lonely activity: a collection of facts (and very pretty pictures) brought down from the mountain by antisocial ""experts"" for them to memorise. Can we change this false perception? I've been experimenting with using role-playing games in the classroom. I've tried these games out on a wide range of high-school and university students. Students play the roles of competing teams of astronomers battling to solve some perplexing astrophysical enigma. Do these games work? Sometimes! When they work well the really change student perceptions of science in a way that almost no other teaching technique can match. But there have been a fair number of embarrassing fiascos along the way... I will share my experiences and hard earned tips for avoiding disasters

  6. Composition and Antioxidant Activity of Water-Soluble Polysaccharides from Tuber indicum

    PubMed Central

    Luo, Qiang; Zhang, Jie; Yan, Liang; Tang, Yuanlin; Ding, Xiang; Yang, Zhirong

    2011-01-01

    Abstract Crude water-soluble Chinese truffle Tuber indicum polysaccharide (TIP) was extracted from the fruiting bodies with water and then successively purified by DEAE–cellulose 52 and Sephadex G-100 column chromatography, yielding two major polysaccharide fractions: TIP1-1 and TIP2-1. High-performance gel permeation chromatography analysis showed that the average molecular sizes of TIP1-1 and TIP2-1 were approximately 1.75×104 Da and 5.73×103 Da, respectively. Monosaccharide component analysis by gas chromatography indicated that TIP1-1 was composed of mannose, glucose, galactose, and rhamannose in the respective molar ratio of 3.93:1.24:0.75:1.26 and that TIP2-1 contained mannose, glucose, and arabinose in the respective molar ratio of 5.27:1.44:0.43. The antioxidant activity analyses revealed that TIP1-1 and TIP2-1 possessed considerable antioxidant activity. Compared with TIP1-1, which has a higher molecular weight and contains no uronic acid, TIP2-1 exhibited a protective effect on PC12 cells injured by H2O2 and a higher scavenging activity against free radicals. The relative effects of the lower molecular size, the presence of uronic acid, and the antioxidant activity of TIP2-1 appear to be significant. Accordingly, the Chinese truffle T. indicum might serve as an effective antioxidative healthcare food and source of natural antioxidants. PMID:21877953

  7. Twelve tips for utilizing principles of learning to support medical education.

    PubMed

    Cutting, Maris F; Saks, Norma Susswein

    2012-01-01

    Research in the cognitive sciences on learning and memory conducted across a range of domains, settings, and age groups has resulted in the identification and formulation of a set of generic learning principles. These learning principles have proven relevant and applicable to a wide range of learning situations in a variety of settings, and can be useful in supporting medical education. They can provide guidance to medical students for efficient and effective study, and can be helpful to faculty to support instructional planning and decisions relating to curriculum. This article discusses evidence-based principles of learning and their relationship to effective learning, teaching, pedagogy and curriculum development. We reviewed important principles of learning to determine those most relevant to improving medical student learning, guiding faculty toward more effective teaching, and in designing a curriculum. Our analysis has resulted in the articulation of key learning principles and specific strategies that are broadly applicable to medical school learning, teaching, and instructional planning. The twelve tips highlight principles of learning that can be effectively applied in the complex learning environment of medical education.

  8. Tips for the First-Year Health Sciences Librarian.

    PubMed

    Brackett, Alexandria

    2016-01-01

    A new librarian offers advice and insights about what she has learned from working at a library within a health science center. The librarian earned her MLIS in spring 2015, and while she had previous teaching experience, she realized there was much more learning needed to properly teach medical, graduate and allied health students, faculty, and residents. In this "one-year on the job" column, the librarian describes the different teaching experiences today's librarians encounter, and reflects on what she has learned from them and how they shape her view of the profession.

  9. Twelve tips for effective body language for medical educators.

    PubMed

    Hale, Andrew J; Freed, Jason; Ricotta, Daniel; Farris, Grace; Smith, C Christopher

    2017-09-01

    A significant proportion of human communication is nonverbal. Although the fields of business and psychology have significant literature on effectively using body language in a variety of situations, there is limited literature on effective body language for medical educators. To provide 12 tips to highlight effective body language strategies and techniques for medical educators. The tips provided are based on our experiences and reflections as clinician-educators and the available literature. The 12 tips presented offer specific strategies to engage learners, balance learner participation, and bring energy and passion to teaching. Medical educators seeking to maximize their effectiveness would benefit from an understanding of how body language affects a learning environment and how body language techniques can be used to engage audiences, maintain attention, control challenging learners, and convey passion for a topic. Understanding and using body language effectively is an important instructional skill.

  10. Cooking Up Mathematics in the Kindergarten.

    ERIC Educational Resources Information Center

    Partridge, Elizabeth; And Others

    1996-01-01

    Discusses ways to use cooking to teach kindergartners about science, language, reading, geography, and mathematics, including number sense, numeration concepts, geometric shapes, and measurement skills. Tips on cooking in class and several recipes are given. (MTE)

  11. Building Fluency through the Phrased Text Lesson

    ERIC Educational Resources Information Center

    Rasinski, Timothy; Yildirim, Kasim; Nageldinger, James

    2012-01-01

    This Teaching Tip article explores the importance of phrasing while reading. It also presents an instructional intervention strategy for helping students develop greater proficiency in reading with phrases that reflect the meaning of the text.

  12. Academic Language in Preschool: Research and Context

    ERIC Educational Resources Information Center

    Michael Luna, Sara

    2017-01-01

    Developing and scaffolding academic language is an important job of preschool teachers. This Teaching Tip provides five strategies that extend the topic of academic language by integrating previous research and field-based data into classroom practice.

  13. Teaching Kids with Learning Difficulties in Today's Classroom: How Every Teacher Can Help Struggling Students Succeed. Revised and Updated Third Edition

    ERIC Educational Resources Information Center

    Winebrenner, Susan

    2014-01-01

    A gold mine of practical, easy­-to-­use teaching methods, strategies, and tips to improve learning outcomes for students who score below proficiency levels. This fully revised and updated third edition provides information on integrated learning, problem solving, and critical thinking in line with Common Core State Standards and 21st-­century…

  14. Multi-Ethnic Literature: Help for the English Teacher. Tips on Selecting and Teaching Works by: Jewish Americans, Chinese Americans, Native Americans, and Black Americans.

    ERIC Educational Resources Information Center

    Matthews, Dorothy, Ed.

    1982-01-01

    The seven articles in this journal issue provide suggestions for teaching multiethnic literature at the high school and college levels. The articles contain the following: (1) a discussion of pluralism and literature in the United States; (2) an analysis of Chinese and Chinese American literature; (3) a review of problems faced by teachers of…

  15. TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Guodong; Tang, Na; Wang, Chao

    Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Current evidence indicates that the oncogenic transcription factor signal transducers and activators of transcription 3 (STAT3) is inappropriately activated in multiple malignancies, including gastric cancer. In this study, we showed that Tipα significantly down-regulated the expression of EMT-related markers E-cadherin as well as up-regulated N-cadherin and vimentin in SGC7901 cells, with typical morphological changes of EMT. Tipα alsomore » promoted proliferation and migration of SGC7901 cells. Furthermore, Tipα activated interleukin-6 (IL-6)/STAT3 signaling pathway in SGC7901 cells. The effects of Tipα treatment observed was abolished when we block IL-6/STAT3 signaling pathway. Altogether, our data demonstrated that Tipα may accelerate tumor aggressiveness in gastric cancer by promoting EMT through activation of IL-6/STAT3 pathway. - Highlights: • Tipα induces EMT and activates IL-6/STAT3 pathway in gastric cancer cells. • IL-6/STAT3 pathway inhibition reverses Tipα-induced proliferation and migration in gastric cancer cells. • Tipα induces EMT in gastric cancer cells via IL-6/STAT3 pathway activation.« less

  16. Phosphorylation regulates the water channel activity of the seed-specific aquaporin alpha-TIP.

    PubMed

    Maurel, C; Kado, R T; Guern, J; Chrispeels, M J

    1995-07-03

    The vacuolar membrane protein alpha-TIP is a seed-specific protein of the Major Intrinsic Protein family. Expression of alpha-TIP in Xenopus oocytes conferred a 4- to 8-fold increase in the osmotic water permeability (Pf) of the oocyte plasma membrane, showing that alpha-TIP forms water channels and is thus a new aquaporin. alpha-TIP has three putative phosphorylation sites on the cytoplasmic side of the membrane (Ser7, Ser23 and Ser99), one of which (Ser7) has been shown to be phosphorylated. We present several lines of evidence that the activity of this aquaporin is regulated by phosphorylation. First, mutation of the putative phosphorylation sites in alpha-TIP (Ser7Ala, Ser23Ala and Ser99Ala) reduced the apparent water transport activity of alpha-TIP in oocytes, suggesting that phosphorylation of alpha-TIP occurs in the oocytes and participates in the control of water channel activity. Second, exposure of oocytes to the cAMP agonists 8-bromoadenosine 3',5'-cyclic monophosphate, forskolin and 3-isobutyl-1-methylxanthine, which stimulate endogenous protein kinase A (PKA), increased the water transport activity of alpha-TIP by 80-100% after 60 min. That the protein can be phosphorylated by PKA was demonstrated by phosphorylating alpha-TIP in isolated oocyte membranes with the bovine PKA catalytic subunit. Third, the integrity of the three sites at positions 7, 23 and 99 was necessary for the cAMP-dependent increase in the Pf of oocytes expressing alpha-TIP, as well as for in vitro phosphorylation of alpha-TIP. These findings demonstrate that the alpha-TIP water channel can be modulated via phosphorylation of Ser7, Ser23 and Ser99.(ABSTRACT TRUNCATED AT 250 WORDS)

  17. Smart helicopter rotor with active blade tips

    NASA Astrophysics Data System (ADS)

    Bernhard, Andreas Paul Friedrich

    2000-10-01

    The smart active blade tip (SABT) rotor is an on-blade rotor vibration reduction system, incorporating active blade tips that can be independently pitched with respect to the main blade. The active blade tip rotor development included an experimental test program culminating in a Mach scale hover test, and a parallel development of a coupled, elastic actuator and rotor blade analysis for preliminary design studies and hover performance prediction. The experimental testing focussed on a small scale rotor on a bearingless Bell-412 hub. The fabricated Mach-scale active-tip rotor has a diameter of 1.524 m, a blade chord of 76.2 mm and incorporated a 10% span active tip. The nominal operating speed is 2000 rpm, giving a tip Mach number of 0.47. The blade tips are driven by a novel piezo-induced bending-torsion coupled actuator beam, located spanwise in the hollow mid-cell of the main rotor blade. In hover at 2000 rpm, at 2 deg collective, and for an actuation of 125 Vrms, the measured blade tip deflection at the first four rotor harmonics is between +/-1.7 and +/-2.8 deg, increasing to +/-5.3 deg at 5/rev with resonant amplification. The corresponding oscillatory amplitude of the rotor thrust coefficient is between 0.7 · 10-3 and 1.3 · 10-1 at the first four rotor harmonics, increasing to 2.1 · 10-3 at 5/rev. In general, the experimental blade tip frequency response and corresponding rotor thrust response are well captured by the analysis. The flexbeam root flap bending moment is predicted in trend, but is significantly over-estimated. The blade tips did not deflect as expected at high collective settings, because of the blade tip shaft locking up in the bearing. This is caused by the high flap bending moment on the blade tip shaft. Redesign of the blade tip shaft assembly and bearing support is identified as the primary design improvement for future research. The active blade tip rotor was also used as a testbed for the evaluation of an adaptive neural-network based control algorithm. Effective background vibration reduction of an intentional 1/rev hover imbalance was demonstrated. The control algorithm also showed the capability to generate desired multi-frequency control loads on the hub, based on artificial signal injection into the vibration measurement. The research program demonstrates the technical feasibility of the active blade tip concept for vibration reduction and warrants further investigation in terms of closed loop forward flight tests in the windtunnel and full scale design studies.

  18. Caregiver Resiliency.

    ERIC Educational Resources Information Center

    Siebert, Al

    2002-01-01

    This article argues that school counselors cannot teach and preach resilient behavior if they are not models of resiliency themselves. Examines why some people come through challenging times more emotionally intact than others and suggests some tips for increasing one's resilience potential. (GCP)

  19. Teaching Tip: Are You Changing the Rules? Again?

    ERIC Educational Resources Information Center

    Rice, Theodore

    2012-01-01

    Students often complain that the rules of mathematics are being changed. A short conversation between a professor and a class of college algebra students dramatizes this in the realm of complex numbers and the legal realm of speed limits.

  20. The Who, How, What, and When of Sexual Harassment: Teaching Tips for Business Educators.

    ERIC Educational Resources Information Center

    Kohl, John P.; Greenlaw, Paul S.

    1993-01-01

    Reviews early court decisions and federal guidelines on sexual harassment. Defines quid pro quo and hostile work environment. Provides suggestions for developing policy and including information on sexual harassment in business curricula. (SK)

  1. Don't Talk, Teach: Breaking Bad Rehearsal Habits.

    ERIC Educational Resources Information Center

    Kruth, Edwin C.

    1984-01-01

    Tips to help conductors improve school music rehearsals are provided. For example, students should learn that the minute the conductor steps on the podium, they should stop playing and talking and direct their attention to the podium. (RM)

  2. Safety Tips: Avoiding Negligence Suits in Chemistry Teaching.

    ERIC Educational Resources Information Center

    Gerlovich, Jack A.

    1983-01-01

    Discusses various aspects related to negligence on the part of chemistry teachers. Areas addressed include negligence in tort law, avoiding negligence suits, proper instructions, proper supervision, equipment maintenance, and other considerations such as sovereign immunity, and contributory versus comparative negligence. (JN)

  3. Application of winglets and/or wing tip extensions with active load control on the Boeing 747

    NASA Technical Reports Server (NTRS)

    Allison, R. L.; Perkin, B. R.; Schoenman, R. L.

    1978-01-01

    The application of wing tip modifications and active control technology to the Boeing 747 airplane for the purpose of improving fuel efficiency is considered. Wing tip extensions, wing tip winglets, and the use of the outboard ailerons for active wing load alleviation are described. Modest performance improvements are indicated. A costs versus benefits approach is taken to decide which, if any, of the concepts warrant further development and flight test leading to possible incorporation into production airplanes.

  4. Tips on Mainstreaming: Do's and Don'ts in Activity Programs.

    ERIC Educational Resources Information Center

    Practical Pointers, 1978

    1978-01-01

    The document provides 10 brief articles on activities for mainstreamed handicapped students. Included are the following titles: "Tips on Mainstreaminq--Do's and Don'ts for Activity Programs;""Mainstreaming--A Goal and A Process;""What To Do When You Meet a Handicapped Person;""Tips for Dealing with Handicapped Persons;""Relatinq to Orthopedically…

  5. Spatially resolved thermal desorption/ionization coupled with mass spectrometry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jesse, Stephen; Van Berkel, Gary J; Ovchinnikova, Olga S

    2013-02-26

    A system and method for sub-micron analysis of a chemical composition of a specimen are described. The method includes providing a specimen for evaluation and a thermal desorption probe, thermally desorbing an analyte from a target site of said specimen using the thermally active tip to form a gaseous analyte, ionizing the gaseous analyte to form an ionized analyte, and analyzing a chemical composition of the ionized analyte. The thermally desorbing step can include heating said thermally active tip to above 200.degree. C., and positioning the target site and the thermally active tip such that the heating step forms themore » gaseous analyte. The thermal desorption probe can include a thermally active tip extending from a cantilever body and an apex of the thermally active tip can have a radius of 250 nm or less.« less

  6. Learning to teach science in a professional development school program

    NASA Astrophysics Data System (ADS)

    Hildreth, David P.

    1997-09-01

    The purpose of this study was to determine the effects of learning to teach science in a Professional Development School (PDS) program on university elementary education preservice teachers' (1) attitudes toward science, (2) science process skills achievement, and (3) sense of science teaching efficacy. Data were collected and analyzed using both quantitative and qualitative methods. Quantitative data were collected using the Science Attitude Inventory (North Carolina Math and Science Education Network (1994), the Test of Integrated Process Skills, TIPS, (Dillashaw & Okey, 1980), and the Science Teaching Efficacy Belief Instrument, STEBI, form B (Enochs & Riggs, 1990). A pretest posttest research design was used for the attitude and process skills constructs. These results were analyzed using paired t test procedures. A pre-experimental group comparison group research design was used for the efficacy construct. Results from this comparison were analyzed using unpaired t test procedures. Qualitative data were collected through students' responses to open-ended questionnaires, narrative interviews, journal entries, small messages, and unsolicited conversations. These data were analyzed via pattern analysis. Posttest scores were significantly higher than pretests scores on both the Science Attitude Inventory and the TIPS. This indicated that students had improved attitudes toward science and science teaching and higher process skills achievement after three semesters in the science-focused PDS program. Scores on the STEBI were significantly higher for students in the pre-experimental group when compared to students in the comparison group. This indicates that students in the science-focused PDS program possessed more efficacious beliefs about science teaching than did the comparison group. Quantitative data were supported by analysis of qualitative data. Implications from this study point to the effectiveness of learning to teach science in a science-focused PDS program with respect to attitudes toward science, science process skills achievement, and sense of science teaching efficacy. In addition, qualitative data indicated that the most effective components of the science-focused PDS program rests largely on the fact that students learned to teach in a collaborative cohort team and that students spent extended periods of time in clinical internships and student teaching.

  7. Safety in the Chemical Laboratory: Advanced Firemanship: How to Teach Your Audience a Lesson.

    ERIC Educational Resources Information Center

    Pitt, Martin J.

    1984-01-01

    Provides tips to assist in preparing a training program designed to show that: (1) fire is dangerous; (2) ordinary individuals can neither understand fire nor extinguish it; and (3) a fire safety officer can do both. (JN)

  8. Helping Your Child through Early Adolescence -- Helping Your Child Series

    MedlinePlus

    ... Bibliography Acknowledgements Tips to Help Your Child through Early Adolescence No Child Left Behind < Previous page | ^ Top ^ | Next page > Printable ... Information About... Transforming Teaching Family and Community Engagement Early Learning Helping Your Child Our mission is to promote student achievement and ...

  9. Comparing three methods for teaching Newton's third law

    NASA Astrophysics Data System (ADS)

    Smith, Trevor I.; Wittmann, Michael C.

    2007-12-01

    Although guided-inquiry methods for teaching introductory physics have been individually shown to be more effective at improving conceptual understanding than traditional lecture-style instruction, researchers in physics education have not studied differences among reform-based curricula in much detail. Several researchers have developed University of Washington style tutorial materials, but the different curricula have not been compared against each other. Our study examines three tutorials designed to improve student understanding of Newton’s third law: the University of Washington’s Tutorials in Introductory Physics (TIP), the University of Maryland’s Activity-Based Tutorials (ABT), and the Open Source Tutorials (OST) also developed at the University of Maryland. Each tutorial was designed with different goals and agendas, and each employs different methods to help students understand the physics. We analyzed pretest and post-test data, including course examinations and data from the Force and Motion Conceptual Evaluation (FMCE). Using both FMCE and course data, we find that students using the OST version of the tutorial perform better than students using either of the other two.

  10. Pollen-tube tip growth requires a balance of lateral propagation and global inhibition of Rho-family GTPase activity

    PubMed Central

    Hwang, Jae-Ung; Wu, Guang; Yan, An; Lee, Yong-Jik; Grierson, Claire S.; Yang, Zhenbiao

    2010-01-01

    Rapid tip growth allows for efficient development of highly elongated cells (e.g. neuronal axons, fungal hyphae and pollen tubes) and requires an elaborate spatiotemporal regulation of the growing region. Here, we use the pollen tube as a model to investigate the mechanism regulating the growing region. ROPs (Rho-related GTPases from plants) are essential for pollen tip growth and display oscillatory activity changes in the apical plasma membrane (PM). By manipulating the ROP activity level, we showed that the PM distribution of ROP activity as an apical cap determines the tip growth region and that efficient tip growth requires an optimum level of the apical ROP1 activity. Excessive ROP activation induced the enlargement of the tip growth region, causing growth depolarization and reduced tube elongation. Time-lapse analysis suggests that the apical ROP1 cap is generated by lateral propagation of a localized ROP activity. Subcellular localization and gain- and loss-of-function analyses suggest that RhoGDI- and RhoGAP-mediated global inhibition limits the lateral propagation of apical ROP1 activity. We propose that the balance between the lateral propagation and the global inhibition maintains an optimal apical ROP1 cap and generates the apical ROP1 activity oscillation required for efficient pollen-tube elongation. PMID:20053639

  11. Radiofrequency energy antenna coupling to common laparoscopic instruments: practical implications.

    PubMed

    Jones, Edward L; Robinson, Thomas N; McHenry, Jennifer R; Dunn, Christina L; Montero, Paul N; Govekar, Henry R; Stiegmann, Greg V

    2012-11-01

    Electromagnetic coupling can occur between the monopolar "Bovie" instrument and other laparoscopic instruments without direct contact by a phenomenon termed antenna coupling. The purpose of this study was to determine if, and to what extent, radiofrequency energy couples to other common laparoscopic instruments and to describe practical steps that can minimize the magnitude of antenna coupling. In a laparoscopic simulator, monopolar radiofrequency energy was delivered to an L-hook. The tips of standard, nonelectrical laparoscopic instruments (either an unlit 10 mm telescope or a 5 mm grasper) were placed adjacent to bovine liver tissue and were never in contact with the active electrode. Thermal imaging quantified the change in tissue temperature nearest the tip of the telescope or grasper at the end of a 5 s activation of the active electrode. A 5 s activation (30 watts, coagulation mode, 4 cm separation between instruments) increased tissue temperature compared with baseline adjacent to the grasper tip (2.2 ± 2.2 °C; p = 0.013) and telescope tip (38.2 ± 8.0 °C; p < 0.001). The laparoscopic telescope tip increased tissue temperature more than the laparoscopic grasper tip (p < 0.001). Lowering the generator power from 30 to 15 Watts decreased the heat generated at the telescope tip (38.2 ± 8.0 vs. 13.5 ± 7.5 °C; p < 0.001). Complete separation of the camera/light cords and the active electrode cord decreased the heat generated near the telescope tip compared with parallel bundling of the cords (38.2 ± 8.0 vs. 15.7 ± 11.6 °C; p < 0.001). Commonly used laparoscopic instruments couple monopolar radiofrequency energy without direct contact with the active electrode, a phenomenon that results in heat transfer from a nonelectrically active instrument tip to adjacent tissue. Practical steps to minimize heat transfer resulting from antenna coupling include reducing the monopolar generator power setting and avoiding of parallel bundling of the telescope and active electrode cords.

  12. Exploring Nonconvex, Crossed and Degenerate Polygons

    ERIC Educational Resources Information Center

    Contreras, Jose N.

    2004-01-01

    An exploration of nonconvex, crossed, and degenerate polygons (NCCDPs) are described with the help of examples with pedagogical tips and recommendations that are found useful when teaching the mathematical process of extending geometric patterns to NCCDPs. The study concludes that investigating such extensions with interactive geometry software…

  13. Formative Assessment in Mathematics for Engineering Students

    ERIC Educational Resources Information Center

    Ní Fhloinn, Eabhnat; Carr, Michael

    2017-01-01

    In this paper, we present a range of formative assessment types for engineering mathematics, including in-class exercises, homework, mock examination questions, table quizzes, presentations, critical analyses of statistical papers, peer-to-peer teaching, online assessments and electronic voting systems. We provide practical tips for the…

  14. Methods and Strategies: Extending the Classroom

    ERIC Educational Resources Information Center

    Smith-Walters, Cindi; Hargrove, Karen; Ervin, Bonnie

    2014-01-01

    This article provides ideas and techniques to improve science teaching, while providing tips for planning and executing field trips. Discussed here are practical planning suggestions for choosing an appropriate destination months before the trip, the cost per student, availability of restroom and lunch facilities, transportation arrangements,…

  15. Exploring Growth (and Mitosis) through a Learning Cycle.

    ERIC Educational Resources Information Center

    Lawson, Anton E.

    1991-01-01

    Presents a learning cycle lesson plan in which students investigate the question of how cells divide. Students use microscopes to explore actual plant root and stem tissues to generate and test hypotheses to answer the question. Includes teacher material, student material, and teaching tips. (MDH)

  16. Teaching Young Children about AIDS.

    ERIC Educational Resources Information Center

    Schonfeld, David J.; Quackenbush, Marcia

    2000-01-01

    AIDS is a genuine concern for young schoolchildren, as a significant number begin having unprotected sex before completing elementary school. The most effective sex-education programs stress delaying the age of first intercourse and adopting safe sexual practices. Principals' supportive behaviors and prevention education tips are discussed. (MLH)

  17. Teaching Tips: Mind Magnets

    ERIC Educational Resources Information Center

    Fortenberry, Callie L.; Fowler, Teri W.

    2006-01-01

    Mind magnets are maps to guide instruction and facilitate the comprehension processes. They extend individual comprehension strategy instruction, which does not typically show students how to link application of appropriate strategies to whole texts. The mind magnet framework allows teachers to plan powerful interactions between the reader and the…

  18. Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies.

    PubMed

    Sun, Yingli; Du, Fengxia

    2017-01-01

    The activation of ATM is critical in the DNA double strand breaks repair pathway. Acetylation of ATM by Tip60 histone acetyltransferase (HAT) plays a key role in the activation of ATM kinase activity in response to DNA damage. ATM forms a stable complex with Tip60 through the FATC domain of ATM. Tip60 acetylates lysine3016 of ATM, and this acetylation induces the activation of ATM. Several techniques are included in the study of ATM acetylation by Tip60, such as in vitro kinase assay, systematic mutagenesis, western blots. Here, we describe how to study the acetylation of ATM using acetylation-specific antibodies.

  19. TRANSLATE: New Strategic Approaches for English Learners

    ERIC Educational Resources Information Center

    Goodwin, Amanda P.; Jiménez, Robert

    2016-01-01

    This teaching tip shares a research-based instructional model that uses translation to improve the English reading comprehension of English Learners. Within this instruction, English learners work collaboratively in small groups and use translation to facilitate understandings of their required English language arts curriculum. Students are taught…

  20. Developing Multiple Choice Tests: Tips & Techniques

    ERIC Educational Resources Information Center

    McCowan, Richard J.

    1999-01-01

    Item writing is a major responsibility of trainers. Too often, qualified staff who prepare lessons carefully and teach conscientiously use inadequate tests that do not validly reflect the true level of trainee achievement. This monograph describes techniques for constructing multiple-choice items that measure student performance accurately. It…

  1. Teaching with Interactive Multimedia.

    ERIC Educational Resources Information Center

    Hudson, Tim

    Based on the idea that anyone who is interested in making entertaining and informative presentations in educational settings is interested in multimedia, this practical guide offers tips for communication (and other) teachers who want to integrate and program interactive multimedia into their courses. The guide suggests that teachers on limited…

  2. The Tip of the Iceberg: The Preparation of Special Education Teachers

    ERIC Educational Resources Information Center

    Kuehn, Jill

    2013-01-01

    This qualitative phenomenological study sought to understand how beginning special education teachers experience the relationship between their teacher training and their actual teaching practice. Effective and insufficient aspects of the teacher training programs of special education teachers were explored. Thirteen special education teachers…

  3. Springboard.

    ERIC Educational Resources Information Center

    RE:view, 1995

    1995-01-01

    Teachers of students with visual impairments share teaching ideas, including a high school student's quilting project (the quilt included raised Braille alphabet letters); development of a ball-tipped cane for travel on nonpaved surfaces, grocery shopping by students for a local food bank, and development of an in-school television news program.…

  4. Tough to Reach, Tough to Teach

    ERIC Educational Resources Information Center

    Rockwell, Sylvia

    2006-01-01

    This resource helps special and general education teachers prepare for encounters with disruptive, defiant, or hostile students by showing them how to defuse undesirable behaviors and structure "face-saving" alternatives. Tips cover setting limits, arranging the classroom for safety, providing a sense of purpose, dealing with parents, and…

  5. Measurement of pressure changes during laser-activated irrigant by an erbium, chromium: yttrium, scandium, gallium, garnet laser.

    PubMed

    Peeters, Harry Huiz; De Moor, Roeland J G

    2015-07-01

    The use of Er,Cr:YSGG laser to activate irrigants results in the creation of vapour bubbles and shockwaves. The present study evaluated the magnitude of pressure changes in the root canal during laser-activated irrigation. The root canal of a single extracted maxillary canine was enlarged to a size 40/0.06 file. A pressure sensor was inserted apically into the root canal. The tooth was processed as follows. In the EDTA condition, the tooth was irrigated with 17 % EDTA; in the NaOCl condition, the tooth was irrigated with 3 % NaOCl. In all conditions, the irrigants were activated at 0.75 and 1.75 W for 60 s using RFT2 and MZ2 tips; to analyse the effect of tip placement, the tip was activated at the orifice and after inserting the tip 5 mm deeper than the orifice. Data showed no significant difference between irrigation regimens (p > 0.05). There were no significant differences of the pressure between RFT2 and MZ2 tips (p > 0.05). The placement of tips closer to the apex resulted in significantly higher pressure than at the orifice (p < 0.001). The use of 1.75 W power resulted in a significantly higher increase of pressure compared to 0.75 W (p < 0.001), regardless either the type of solutions or tips used. The magnitude of the pressure changes in the root canal at 0.75 W was significantly lower than 1.75 W regardless of either type of tips or solutions used. The closer the insertion of the tip to the apex, the higher the pressure.

  6. A Scalable Heuristic for Viral Marketing Under the Tipping Model

    DTIC Science & Technology

    2013-09-01

    removal of high-degree nodes. The rest of the paper is organized as follows. In Section 2, we provide formal definitions of the tipping model. This is...that must be activated for it to become activate as well. A Scalable Heuristic for Viral Marketing Under the Tipping Model 3 Definition 1 (Threshold...returns a set of active nodes after one time step. Definition 2 (Activation Function) Given a threshold function, θ, an ac- tivation function Aθ maps

  7. Twelve tips for facilitating Millennials' learning.

    PubMed

    Roberts, David H; Newman, Lori R; Schwartzstein, Richard M

    2012-01-01

    The current, so-called "Millennial" generation of learners is frequently characterized as having deep understanding of, and appreciation for, technology and social connectedness. This generation of learners has also been molded by a unique set of cultural influences that are essential for medical educators to consider in all aspects of their teaching, including curriculum design, student assessment, and interactions between faculty and learners.  The following tips outline an approach to facilitating learning of our current generation of medical trainees.  The method is based on the available literature and the authors' experiences with Millennial Learners in medical training.  The 12 tips provide detailed approaches and specific strategies for understanding and engaging Millennial Learners and enhancing their learning.  With an increased understanding of the characteristics of the current generation of medical trainees, faculty will be better able to facilitate learning and optimize interactions with Millennial Learners.

  8. Teaching Mistakes or Teachable Moments?

    ERIC Educational Resources Information Center

    Mueller, Mary; Yankelewitz, Dina

    2014-01-01

    Gain a new perspective on the sharing of erroneous solutions in classroom discussions. Based on their research in grades four and six, the authors reveal how student-to-student correction of errors promotes mathematical reasoning and understanding. Tips for teachers include strategies for using students' errors to encourage reasoning during…

  9. Reading and the English Teacher.

    ERIC Educational Resources Information Center

    Matthews, Dorothy, Ed.

    1977-01-01

    In this issue, articles deal with various aspects of the relationship between reading and the English teacher. Titles include "Literary Humor" by Wilmer Lamar and "200 Adolescent Novels Worth Reading" by Ken Donelson; both suggest reading materials. Practical teaching tips are provided in "Comprehension Is Comprehension, Is . . ." by Jerry Walker,…

  10. Teaching Tip: Play Ball--Bringing Scrum into the Classroom

    ERIC Educational Resources Information Center

    May, Jeffrey; York, Jim; Lending, Diane

    2016-01-01

    Scrum has become a widely-used framework for technology development in both private industry and the government. As a result, Information Systems recruiters and executives have recently been placing a focus on students with Scrum knowledge. Unfortunately, current System Analysis and Design textbooks provide cursory attention to Scrum. Thus, the…

  11. Direction-Giving Skills in the Classroom (A Teaching Tip).

    ERIC Educational Resources Information Center

    Ross, Charlynn

    1992-01-01

    Offers a unit on direction giving to help students identify effective and ineffective direction giving; become familiar with the preparation and presentation components of sound direction giving; and determine whether the message intended was the massage received. Discusses barriers to listening, misunderstandings, and provides exercises and steps…

  12. Physical Education for Students with Special Needs. Curriculum Support Series.

    ERIC Educational Resources Information Center

    Mahon, Michael J.

    The guide is intended to assist Manitoba physical education teachers in the process of integrating students with disabilities into regular physical education classes. The manual provides an introduction to students with special needs, stresses the need to create an accepting environment, discusses various teaching tips, and highlights resources…

  13. Deaf Adult Literacy Tutor Handbook--Revision (Final Report).

    ERIC Educational Resources Information Center

    Bober, Gail, Comp.

    This handbook is designed for individuals who tutor hearing impaired adults in literacy skills. It provides general information about a number of topics: adult learners; deaf adult learners; deaf awareness; deaf culture; communication tips; language, communication, and literacy for deaf adults; and teaching strategies. A 13-page report describes…

  14. The Four-Part Literature Review Process: Breaking It Down for Students

    ERIC Educational Resources Information Center

    Price, Rebecca H.

    2017-01-01

    Both undergraduate and graduate students face similar challenges when tasked with writing literature reviews. Breaking down the literature review into a four-part process helps students decrease frustration and increase quality. This article provides usable advice for anyone teaching or writing literature reviews. Tips and illustrations illuminate…

  15. The Human Health, Growth, and Development Curriculum.

    ERIC Educational Resources Information Center

    Boyles, Linda R.; And Others

    This health and human development curriculum for grades 1-6 contains tips for teachers and overviews of the philosophy behind teaching these topics to elementary school students. The section on health education is structured around ten content strands: (1) health knowledge, attitudes, decisions, and behavior; (2) emotional and social health; (3)…

  16. Bringing Stories to Life: Integrating Literature and Math Manipulatives

    ERIC Educational Resources Information Center

    Larson, Lotta C.; Rumsey, Chepina

    2018-01-01

    This Teaching Tip describes the use of children's literature to help second-grade students meet Common Core State Standards for English Language Arts and for Mathematics. During a shared reading experience, students used manipulatives to represent plot and characters while demonstrating mathematical reasoning. The article offers instructional…

  17. Designing Design into an Advanced Desktop Publishing Course (A Teaching Tip).

    ERIC Educational Resources Information Center

    Guthrie, Jim

    1995-01-01

    Describes an advanced desktop publishing course that combines instruction in a few advanced techniques for using software with extensive discussion of such design principles as consistency, proportion, asymmetry, appropriateness, contrast, and color. Describes computer hardware and software, class assignments, problems, and the rationale for such…

  18. Helping Your Child Learn Self-Care.

    ERIC Educational Resources Information Center

    Murphy, Linda; Corte, Suzanne Della

    1987-01-01

    Practical advice for parents of handicapped children is the focus of this issue on self-care skills including self-feeding, dressing, and personal hygiene. Ten initial tips for teaching skills to children include constant repetition, modeling, and keeping verbal instruction to a minimum. The section on self-feeding addresses the topics of…

  19. Expanding the Understanding of Evolution

    ERIC Educational Resources Information Center

    Musante, Susan

    2011-01-01

    Originally designed for K-12 teachers, the Understanding Evolution (UE) Web site ("www.understandingevolution.org") is a one-stop shop for all of a teacher's evolution education needs, with lesson plans, teaching tips, lists of common evolution misconceptions, and much more. However, during the past five years, the UE project team learned that…

  20. Machine Dictation and Transcription.

    ERIC Educational Resources Information Center

    Harvey, Evelyn; And Others

    This instructional package contains both an instructor's manual and a student's manual for a course in machine dictation and transcription. The instructor's manual contains an overview with tips on teaching the course, letters for dictation, and a key to the letters. The student's manual contains an overview of the course and of the skills needed…

  1. A ginseng PgTIP1 gene whose protein biological activity related to Ser(128) residue confers faster growth and enhanced salt stress tolerance in Arabidopsis.

    PubMed

    Li, Jia; Cai, Weiming

    2015-05-01

    Water movement across cellular membranes is mostly regulated by aquaporins. A tonoplast intrinsic protein PgTIP1 from Panax ginseng has been found to play an important role in plant growth and development, and also in the response of plants to abiotic stress. However, the regulation of its function and activity remains unknown. To answer this question, mutated forms of PgTIP1 were made by replacing Ser(128) with Ala (named S128A) or Asp (named S128D), and also by replacing Thr(54) with Ala (named T54A) or Asp (named T54D). Then, wild type or mutated PgTIP1 was expressed in yeast and water transport was monitored in protoplasts. The substitution of Ser(128) abolished the water channel activity of PgTIP1, while the substitution of Thr(54) did not inhibit its activity. Moreover, the overexpression of PgTIP1 but not S128A or S128D in Arabidopsis significantly increased plant growth as determined by biomass production, it also had a beneficial effect on salt stress tolerance. Importantly, the overexpression of PgTIP1 led to the altered expression of stress-related genes, which made the plants more tolerant to salt stress. Our results demonstrated that PgTIP1 conferred faster growth and enhanced tolerance to salt in Arabidopsis, and that its biological activity related to Ser(128) residue. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  2. Rational design and validation of a Tip60 histone acetyltransferase inhibitor

    NASA Astrophysics Data System (ADS)

    Gao, Chunxia; Bourke, Emer; Scobie, Martin; Famme, Melina Arcos; Koolmeister, Tobias; Helleday, Thomas; Eriksson, Leif A.; Lowndes, Noel F.; Brown, James A. L.

    2014-06-01

    Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone acetyltransferases (HATs) and histone deacetylases and currently, few general HAT inhibitors have been described. We identified the HAT Tip60 as an excellent candidate for targeted drug development, as Tip60 is a key mediator of the DNA damage response and transcriptional co-activator. Our modeling of Tip60 indicated that the active binding pocket possesses opposite charges at each end, with the positive charges attributed to two specific side chains. We used structure based drug design to develop a novel Tip60 inhibitor, TH1834, to fit this specific pocket. We demonstrate that TH1834 significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage (following ionizing radiation treatment) in breast cancer but not control cell lines. Furthermore, TH1834 did not affect the activity of related HAT MOF, as indicated by H4K16Ac, demonstrating specificity. The modeling and validation of the small molecule inhibitor TH1834 represents a first step towards developing additional specific, targeted inhibitors of Tip60 that may lead to further improvements in the treatment of breast cancer.

  3. HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

    PubMed Central

    Col, Edwige; Caron, Cécile; Chable-Bessia, Christine; Legube, Gaelle; Gazzeri, Sylvie; Komatsu, Yasuhiko; Yoshida, Minoru; Benkirane, Monsef; Trouche, Didier; Khochbin, Saadi

    2005-01-01

    HIV-1 transactivator Tat uses cellular acetylation signalling by targeting several cellular histone acetyltransferases (HAT) to optimize its various functions. Although Tip60 was the first HAT identified to interact with Tat, the biological significance of this interaction has remained obscure. We had previously shown that Tat represses Tip60 HAT activity. Here, a new mechanism of Tip60 neutralization by Tat is described, where Tip60 is identified as a substrate for the newly reported p300/CBP-associated E4-type ubiquitin-ligase activity, and Tat uses this mechanism to induce the polyubiquitination and degradation of Tip60. Tip60 targeting by Tat results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage. These data reveal yet unknown strategies developed by HIV-1 to increase cell resistance to genotoxic stresses and show a role of Tat as a modulator of cellular protein ubiquitination. PMID:16001085

  4. CERT: Center of Excellence in Rotorcraft Technology

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The research objectives of this effort are to understand the physical processes that influence the formation of the tip vortex of a rotor in advancing flight, and to develop active and passive means of weakening the tip vortex during conditions when strong blade-vortex-interaction effects are expected. A combined experimental, analytical, and computational effort is being employed. Specifically, the following efforts are being pursued: 1. Analytical evaluation and design of combined elastic tailoring and active material actuators applicable to rotor blade tips. 2. Numerical simulations of active and passive tip devices. 3. LDV Measurement of the near and far wake behind rotors in forward flight.

  5. Fuel injection assembly for gas turbine engine combustor

    NASA Technical Reports Server (NTRS)

    Candy, Anthony J. (Inventor); Glynn, Christopher C. (Inventor); Barrett, John E. (Inventor)

    2002-01-01

    A fuel injection assembly for a gas turbine engine combustor, including at least one fuel stem, a plurality of concentrically disposed tubes positioned within each fuel stem, wherein a cooling supply flow passage, a cooling return flow passage, and a tip fuel flow passage are defined thereby, and at least one fuel tip assembly connected to each fuel stem so as to be in flow communication with the flow passages, wherein an active cooling circuit for each fuel stem and fuel tip assembly is maintained by providing all active fuel through the cooling supply flow passage and the cooling return flow passage during each stage of combustor operation. The fuel flowing through the active cooling circuit is then collected so that a predetermined portion thereof is provided to the tip fuel flow passage for injection by the fuel tip assembly.

  6. Estrogen receptor β (ERβ1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner.

    PubMed

    Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei

    2013-08-30

    Estrogen receptor (ER) β1 and ERα have overlapping and distinct functions despite their common use of estradiol as the physiological ligand. These attributes are explained in part by their differential utilization of coregulators and ligands. Although Tip60 has been shown to interact with both receptors, its regulatory role in ERβ1 transactivation has not been defined. In this study, we found that Tip60 enhances transactivation of ERβ1 at the AP-1 site but suppresses its transcriptional activity at the estrogen-response element (ERE) site in an estradiol-independent manner. However, different estrogenic compounds can modify the Tip60 action. The corepressor activity of Tip60 at the ERE site is abolished by diarylpropionitrile, genistein, equol, and bisphenol A, whereas its coactivation at the AP-1 site is augmented by fulvestrant (ICI 182,780). GRIP1 is an important tethering mediator for ERs at the AP-1 site. We found that coexpression of GRIP1 synergizes the action of Tip60. Although Tip60 is a known acetyltransferase, it is unable to acetylate ERβ1, and its coregulatory functions are independent of its acetylation activity. In addition, we showed the co-occupancy of ERβ1 and Tip60 at ERE and AP-1 sites of ERβ1 target genes. Tip60 differentially regulates the endogenous expression of the target genes by modulating the binding of ERβ1 to the cis-regulatory regions. Thus, we have identified Tip60 as the first dual-function coregulator of ERβ1.

  7. Estrogen Receptor β (ERβ1) Transactivation Is Differentially Modulated by the Transcriptional Coregulator Tip60 in a cis-Acting Element-dependent Manner*

    PubMed Central

    Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei

    2013-01-01

    Estrogen receptor (ER) β1 and ERα have overlapping and distinct functions despite their common use of estradiol as the physiological ligand. These attributes are explained in part by their differential utilization of coregulators and ligands. Although Tip60 has been shown to interact with both receptors, its regulatory role in ERβ1 transactivation has not been defined. In this study, we found that Tip60 enhances transactivation of ERβ1 at the AP-1 site but suppresses its transcriptional activity at the estrogen-response element (ERE) site in an estradiol-independent manner. However, different estrogenic compounds can modify the Tip60 action. The corepressor activity of Tip60 at the ERE site is abolished by diarylpropionitrile, genistein, equol, and bisphenol A, whereas its coactivation at the AP-1 site is augmented by fulvestrant (ICI 182,780). GRIP1 is an important tethering mediator for ERs at the AP-1 site. We found that coexpression of GRIP1 synergizes the action of Tip60. Although Tip60 is a known acetyltransferase, it is unable to acetylate ERβ1, and its coregulatory functions are independent of its acetylation activity. In addition, we showed the co-occupancy of ERβ1 and Tip60 at ERE and AP-1 sites of ERβ1 target genes. Tip60 differentially regulates the endogenous expression of the target genes by modulating the binding of ERβ1 to the cis-regulatory regions. Thus, we have identified Tip60 as the first dual-function coregulator of ERβ1. PMID:23857583

  8. Effect of ultrasonic tip designs on intraradicular post removal.

    PubMed

    Aguiar, Anny Carine Barros; de Meireles, Daniely Amorim; Marques, André Augusto Franco; Sponchiado Júnior, Emílio Carlos; Garrido, Angela Delfina Bitencourt; Garcia, Lucas da Fonseca Roberti

    2014-11-01

    To evaluate the effect of different ultrasonic tip designs on intraradicular post removal. The crowns of forty human canine teeth were removed, and after biomechanical preparation and filling, the roots were embedded in acrylic resin blocks. The post spaces were made, and root canal molding was performed with self-cured acrylic resin. After casting (Cu-Al), the posts were cemented with zinc phosphate cement. The specimens were randomly separated into 4 groups (n = 10), as follows: G1 - no ultrasonic vibration (control); G2 - ultrasonic vibration using an elongated cylindrical-shaped and active rounded tip; G3 - ultrasonic vibration with a flattened convex and linear active tip; G4 - ultrasonic vibration with active semicircular tapered tip. Ultrasonic vibration was applied for 15 seconds on each post surface and tensile test was performed in a Universal Testing Machine (Instron 4444 - 1 mm/min). G4 presented the highest mean values, however, with no statistically significant difference in comparison to G3 (P > 0.05). G2 presented the lowest mean values with statistically significant difference to G3 and G4 (P < 0.05). Ultrasonic vibration with elongated cylindrical-shaped and active rounded tip was most effective in reducing force required for intraradicular post removal.

  9. Preschoolers' Author-illustrator Study of Donald Crews

    ERIC Educational Resources Information Center

    Meacham, Sohyun; Meacham, Shuaib; Kirkland-Holmes, Gloria; Han, Myae

    2017-01-01

    This teaching tip reports a case of an author-illustrator study of Donald Crews. It discusses the suitability of his books for an author-illustrator study in preschool classrooms and emphasizes the significance of his work for family literacy among racial and ethnic minority groups. A Head Start classroom of preschoolers investigated Crews's books…

  10. Getting Tenure in a Down Economy

    ERIC Educational Resources Information Center

    Shaw, Darla; Maidment, Fred

    2010-01-01

    Academic tenure is now under attack. A down economy has placed greater pressure on institutions making tenure more difficult to obtain. Nineteen tips for gaining tenure in a down economy are presented along with several justifications for tenure and why tenure is important for the preservation of the academy and the freedom to research and teach.

  11. Tips and Tulips: A Resource Manual for Teachers of Bilingual Students.

    ERIC Educational Resources Information Center

    Reifenrath, Gloria; Rowch, Nancy

    Written to assist the classroom teacher of limited or non-English speaking students, this manual suggests ways to teach the four components of language--listening, speaking, reading, and writing. Each component is handled in a separate section that provides theoretical background followed by suggestions for instruction that can be adapted for…

  12. Top Ten Tips for Student Teaching in Kindergarten

    ERIC Educational Resources Information Center

    McKenna, Beverly A.; Strauser, Beverly A.

    2010-01-01

    Kindergarten student teachers face a unique set of challenges as they strive to meet the needs of very young children. This article presents ten suggestions for ensuring a successful experience. They are based on the authors' many years of experience in working with student teachers placed in kindergarten settings. Arranged in Letterman fashion in…

  13. Peer Pressure: An Issue That Crosses Generations.

    ERIC Educational Resources Information Center

    Kittredge, Karen; McCarthy, Alice R.

    2000-01-01

    Recent research on peer pressure shows that: parents are important to teens, today's teens face unique challenges, and teaching teens to say no does not mean losing friends. The paper presents parenting tips for countering peer pressure, noting the influence of adult peer pressure on children. A sidebar examines the right age to start talking to…

  14. Schoolyard Lessons: More and More Schools Are Finding Ways To Take Education Outdoors.

    ERIC Educational Resources Information Center

    Boss, Suzie

    2001-01-01

    School gardens can teach kids about cooperation, nature, science, creativity, and community service. Gardens also help teachers address students' diverse needs and interests. Tips for school gardeners include: make it easy to use, keep groups small, be inclusive, build partnerships, have clear rules, think year-round, have fun, and celebrate…

  15. Dialogue: A Teaching Guide to Nuclear Issues.

    ERIC Educational Resources Information Center

    Educators for Social Responsibility, Cambridge, MA.

    Materials in this manual are designed to help educators raise the issue of nuclear war through a "day of dialog" on the subject. There are seven sections. Section 1 contains a project reationale; suggestions for implementation; methods for meeting resistance; tips for schoolwide, parent-teacher, and community discussion; uses of the media; and…

  16. National Assessments for Student Teachers: Documenting Teaching Readiness to the Tipping Point

    ERIC Educational Resources Information Center

    Margolis, Jason; Doring, Anne

    2013-01-01

    To evaluate the impact of the emergent national teacher performance assessment (TPA) on student teachers, this study examined a pilot implementation at one university in Washington State during Spring 2011. The qualitative research focused on the lived experience of those directly affected by TPA implementation: student teachers, mentor teachers,…

  17. Meeting Core Requirements through Efficient Time Management. Teaching Tips.

    ERIC Educational Resources Information Center

    Prusak, Keven

    1997-01-01

    Using a basketball unit as an example, this paper presents a model to help middle school physical educators accomplish a proper warmup, stretch, and cardiovascular workout as required by state core requirements without sacrificing time for skills acquisition and play. Concepts of individual goal setting and goal achievement are an inherent part of…

  18. Everyday Innovation: Ten Practical Tips for Fostering Innovation

    ERIC Educational Resources Information Center

    Simkins, Michael

    2006-01-01

    For educators to be successful in teaching students to step up and become tomorrow's innovators, they must become innovators themselves. Enter school leadership. This article provides 10 practical steps any superintendent, principal, or other administrator can take to help make that happen: (1) Go on record; (2) Model innovation; (3) Pollinate;…

  19. Family Literacy and Global Literature: Parents as Partners in the Common Core

    ERIC Educational Resources Information Center

    Truesdell, Kim S.; del Prado Hill, Pixita

    2015-01-01

    This "Teaching Tip" will explain an initiative, Global Book Hour, that engages families in a global literature read aloud. GBH integrates social studies, the visual and performing arts, healthy eating, and vocabulary development as children travel the world through high quality global children's literature. The program is a…

  20. 10 Research-Based Tips for Enhancing Literacy Instruction for Students with Intellectual Disability

    ERIC Educational Resources Information Center

    Lemons, Christopher J.; Allor, Jill H.; Al Otaiba, Stephanie; LeJeune, Lauren M.

    2016-01-01

    In the past 2 decades, researchers (often working closely with parents, teachers, and other school staff members) have conducted studies that have substantially increased understanding how to effectively teach children and adolescents with intellectual disability (ID) to read. This research focus has been fueled by increased societal expectations…

  1. Introducing and Sustaining Close Reading and Writing through Poetry

    ERIC Educational Resources Information Center

    Timmermans, Karren M.; Johnson, Angie

    2017-01-01

    Close reading of poetry scaffolds readers and writers as they come to understand the form and function of poetry and transfer those skills to writing. In this teaching tip, the authors explain a way in which primary teachers can introduce close reading and move young students toward composing and presenting poetry.

  2. Teaching with the Brain in Mind.

    ERIC Educational Resources Information Center

    Jensen, Eric

    This book reviews recent research and theory on the brain and balances this information with tips and techniques for using the information in classrooms. Brain-compatible learning is explored in the following chapters: (1) "The New Winds of Change"; (2) "The Learning Brain"; (3) "Getting Students Ready To Learn"; (4) "Enriched Environments and the…

  3. Assessment of Abdominal Pain in School-Age Children

    ERIC Educational Resources Information Center

    Zimmermann, Polly Gerber

    2003-01-01

    Pediatric abdominal pain can be a difficult condition to accurately assess for the nurse to determine whether the child's need is for teaching, treating, or transferring. This article describes the process as well as practical tips to be used by the nurse in the school setting. Distinguishing characteristics and findings, including key physical…

  4. 13 Tips for Virtual World Teaching

    ERIC Educational Resources Information Center

    Villano, Matt

    2008-01-01

    Multi-user virtual environments (MUVEs) are gaining momentum as the latest and greatest learning tool in the world of education technology. How does one get started with them? How do they work? This article shares 13 secrets from immersive education experts and educators on how to have success in implementing these new tools and technologies on…

  5. An Innovative Spreadsheet Application to Teach Management Science Decision Criteria

    ERIC Educational Resources Information Center

    Hozak, Kurt

    2018-01-01

    This article describes a Microsoft Excel-based application that uses humorous voice synthesis and timed competition to make it more fun and engaging to learn management science decision criteria. In addition to providing immediate feedback and easily customizable tips that facilitate self-learning, the software randomly generates both the problem…

  6. Idea Bank: Using Apps That Support Scientific Practices

    ERIC Educational Resources Information Center

    Mills, Kelly; Seligman, Eileen; Ketelhut, Diane Jass

    2017-01-01

    The Idea Bank provides tips and techniques for creative teaching, in about 1,000 words. For this article, the authors analyzed 93 educational applications (apps) that have the potential to help students meaningfully engage in the science practices outlined in the Next Generation Science Standards. Some of the ways teachers can use these apps in…

  7. Tips for Using Interactive Whiteboards to Increase Participation of Students with Disabilities

    ERIC Educational Resources Information Center

    Whitby, Peggy J. S.; Leininger, Mark L.; Grillo, Kelly

    2012-01-01

    Whiteboard technology has become commonplace in the inclusive classroom and has the potential to merge traditional teaching pedagogy with the technological age. However, teachers report little training on how to incorporate whiteboards into lesson planning. The number of students with disabilities educated in the general education setting has…

  8. Graphic Communications--Preparatory Area. Book I--Typography and Modern Typesetting. Teacher's Manual.

    ERIC Educational Resources Information Center

    Hertz, Andrew

    Intended for use with a companion student manual, this teacher's guide lists procedures and teaching tips for each unit of a secondary or postsecondary course of study in typography and modern typesetting. Course objectives are listed for developing student skills in the following preparatory functions of the graphic communications industry: copy…

  9. Caught up in Curiosity: Genius Hour in the Kindergarten Classroom

    ERIC Educational Resources Information Center

    West, JoAnne M.; Roberts, Kathryn L.

    2016-01-01

    Choice and interest have long been linked to motivation for learning to read and write; however, designing instruction with authentic premises for young children that harness these motivators can prove challenging. In this teaching tip, we describe one kindergarten classroom's experience engaging in Genius Hour, in which children were supported to…

  10. Teaching Students with Developmental Disabilities: Tips from Teens and Young Adults with Fetal Alcohol Spectrum Disorder

    ERIC Educational Resources Information Center

    Duquette, Cheryll; Stodel, Emma; Fullarton, Stephanie; Hagglund, Karras

    2006-01-01

    Fetal Alcohol Spectrum Disorder (FASD) is a term that encompasses the various neurodevelopmental disorders experienced by individuals with prenatal alcohol exposure. FASD incorporates the terms Fetal Alcohol Syndrome (FAS), Fetal Alcohol Effects (FAE), and Alcohol-Related Neurodevelopmental Disorder (ARND). Early studies showed that students with…

  11. Tips for Teaching: Using Cognitive and Metacognitive Learning Strategies in the Classroom.

    ERIC Educational Resources Information Center

    Lambert, Monica A.

    2000-01-01

    This article describes three cognitive and metacognitive learning strategies for students with disabilities, including the CAST (character, action, setting, the end) reading strategy, the PLEASE writing strategy, and the LISTEN (look, idle your motor, sit up straight, turn to me, engage your brain, now.) social skills strategy. (Contains…

  12. Big 6 Tips: Teaching Information Problem Solving. #1 Task Definition: What Needs To Be Done.

    ERIC Educational Resources Information Center

    Eisenberg, Michael

    1997-01-01

    Explains task definition which is the first stage in the Big 6, an approach to information and technology skills instruction. Highlights include defining the problem; identifying the information requirements of the problem; transferability from curriculum-based problems to everyday tasks; and task definition logs kept by students. (LRW)

  13. Teaching Information Ethics to High School Students

    ERIC Educational Resources Information Center

    Lehman, Kathy

    2009-01-01

    The new AASL standards clearly spell out ethical responsibilities, which school librarians strive to instill and model as they work with staff and students. In this article, the author presents the AASL standards together with some tips and lesson ideas which she and her library partner have put into practice within their library media program.

  14. Teaching Tip: Using Rapid Game Prototyping for Exploring Requirements Discovery and Modeling

    ERIC Educational Resources Information Center

    Dalal, Nikunj

    2012-01-01

    We describe the use of rapid game prototyping as a pedagogic technique to experientially explore and learn requirements discovery, modeling, and specification in systems analysis and design courses. Students have a natural interest in gaming that transcends age, gender, and background. Rapid digital game creation is used to build computer games…

  15. The 21st-Century Syllabus: Tips for Putting Andragogy into Practice

    ERIC Educational Resources Information Center

    Lund Dean, Kathy; Fornaciari, Charles J.

    2014-01-01

    In our previous article about reconceptualizing the course syllabus, we argued that instructors must move syllabi beyond their traditional pedagogically-inspired focus on operational course norms if the syllabus is to remain relevant as a teaching and learning tool. Here, we take the andragogical ideas developed in the prior article and provide…

  16. JobTIPS: A Transition to Employment Program for Individuals with Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Strickland, Dorothy C.; Coles, Claire D.; Southern, Louise B.

    2013-01-01

    This study evaluated the effectiveness of an internet accessed training program that included Theory of Mind-based guidance, video models, visual supports, and virtual reality practice sessions in teaching appropriate job interview skills to individuals with high functioning Autism Spectrum Disorders. In a randomized study, twenty-two youth, ages…

  17. Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri

    PubMed Central

    Vernot, Jean-Paul; Perdomo-Arciniegas, Ana María; Pérez-Quintero, Luis Alberto; Martínez, Diego Fernando

    2015-01-01

    The Lck interacting protein Tip of Herpesvirus saimiri is responsible for T-cell transformation both in vitro and in vivo. Here we designed the chimeric peptide hTip-CSKH, comprising the Lck specific interacting motif CSKH of Tip and its hydrophobic transmembrane sequence (hTip), the latter as a vector targeting lipid rafts. We found that hTip-CSKH can induce a fivefold increase in proliferation of human and Aotus sp. T-cells. Costimulation with PMA did not enhance this proliferation rate, suggesting that hTip-CSKH is sufficient and independent of further PKC stimulation. We also found that human Lck phosphorylation was increased earlier after stimulation when T-cells were incubated previously with hTip-CSKH, supporting a strong signalling and proliferative effect of the chimeric peptide. Additionally, Lck downstream signalling was evident with hTip-CSKH but not with control peptides. Importantly, hTip-CSKH could be identified in heavy lipid rafts membrane fractions, a compartment where important T-cell signalling molecules (LAT, Ras, and Lck) are present during T-cell activation. Interestingly, hTip-CSKH was inhibitory to Jurkat cells, in total agreement with the different signalling pathways and activation requirements of this leukemic cell line. These results provide the basis for the development of new compounds capable of modulating therapeutic targets present in lipid rafts. PMID:26539553

  18. Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri.

    PubMed

    Vernot, Jean-Paul; Perdomo-Arciniegas, Ana María; Pérez-Quintero, Luis Alberto; Martínez, Diego Fernando

    2015-01-01

    The Lck interacting protein Tip of Herpesvirus saimiri is responsible for T-cell transformation both in vitro and in vivo. Here we designed the chimeric peptide hTip-CSKH, comprising the Lck specific interacting motif CSKH of Tip and its hydrophobic transmembrane sequence (hTip), the latter as a vector targeting lipid rafts. We found that hTip-CSKH can induce a fivefold increase in proliferation of human and Aotus sp. T-cells. Costimulation with PMA did not enhance this proliferation rate, suggesting that hTip-CSKH is sufficient and independent of further PKC stimulation. We also found that human Lck phosphorylation was increased earlier after stimulation when T-cells were incubated previously with hTip-CSKH, supporting a strong signalling and proliferative effect of the chimeric peptide. Additionally, Lck downstream signalling was evident with hTip-CSKH but not with control peptides. Importantly, hTip-CSKH could be identified in heavy lipid rafts membrane fractions, a compartment where important T-cell signalling molecules (LAT, Ras, and Lck) are present during T-cell activation. Interestingly, hTip-CSKH was inhibitory to Jurkat cells, in total agreement with the different signalling pathways and activation requirements of this leukemic cell line. These results provide the basis for the development of new compounds capable of modulating therapeutic targets present in lipid rafts.

  19. Twelve tips for getting started using mixed methods in medical education research.

    PubMed

    Lavelle, Ellen; Vuk, Jasna; Barber, Carolyn

    2013-04-01

    Mixed methods research, which is gaining popularity in medical education, provides a new and comprehensive approach for addressing teaching, learning, and evaluation issues in the field. The aim of this article is to provide medical education researchers with 12 tips, based on consideration of current literature in the health professions and in educational research, for conducting and disseminating mixed methods research. Engaging in mixed methods research requires consideration of several major components: the mixed methods paradigm, types of problems, mixed method designs, collaboration, and developing or extending theory. Mixed methods is an ideal tool for addressing a full range of problems in medical education to include development of theory and improving practice.

  20. Tips for Starting Physical Activity

    MedlinePlus

    ... For Reporters Meetings & Workshops Follow Us Home Health Information Weight Management Tips to Help You Get Active Starting Physical ... at NIDDK Technology Advancement & Transfer Meetings & Workshops Health Information ... Disease Urologic Diseases Endocrine Diseases Diet & Nutrition ...

  1. Abscisic acid accumulation modulates auxin transport in the root tip to enhance proton secretion for maintaining root growth under moderate water stress.

    PubMed

    Xu, Weifeng; Jia, Liguo; Shi, Weiming; Liang, Jiansheng; Zhou, Feng; Li, Qianfeng; Zhang, Jianhua

    2013-01-01

    Maintenance of root growth is essential for plant adaptation to soil drying. Here, we tested the hypothesis that auxin transport is involved in mediating ABA's modulation by activating proton secretion in the root tip to maintain root growth under moderate water stress. Rice and Arabidopsis plants were raised under a hydroponic system and subjected to moderate water stress (-0.47 MPa) with polyethylene glycol (PEG). ABA accumulation, auxin transport and plasma membrane H(+)-ATPase activity at the root tip were monitored in addition to the primary root elongation and root hair density. We found that moderate water stress increases ABA accumulation and auxin transport in the root apex. Additionally, ABA modulation is involved in the regulation of auxin transport in the root tip. The transported auxin activates the plasma membrane H(+)-ATPase to release more protons along the root tip in its adaption to moderate water stress. The proton secretion in the root tip is essential in maintaining or promoting primary root elongation and root hair development under moderate water stress. These results suggest that ABA accumulation modulates auxin transport in the root tip, which enhances proton secretion for maintaining root growth under moderate water stress. © 2012 The Authors. New Phytologist © 2012 New Phytologist Trust.

  2. A Parametric Study of Actuator Requirements for Active Turbine Tip Clearance Control of a Modern High Bypass Turbofan Engine

    NASA Technical Reports Server (NTRS)

    Kratz, Jonathan L.; Chapman, Jeffryes W.; Guo, Ten-Huei

    2017-01-01

    The efficiency of aircraft gas turbine engines is sensitive to the distance between the tips of its turbine blades and its shroud, which serves as its containment structure. Maintaining tighter clearance between these components has been shown to increase turbine efficiency, increase fuel efficiency, and reduce the turbine inlet temperature, and this correlates to a longer time-on-wing for the engine. Therefore, there is a desire to maintain a tight clearance in the turbine, which requires fast response active clearance control. Fast response active tip clearance control will require an actuator to modify the physical or effective tip clearance in the turbine. This paper evaluates the requirements of a generic active turbine tip clearance actuator for a modern commercial aircraft engine using the Commercial Modular Aero-Propulsion System Simulation 40k (C-MAPSS40k) software that has previously been integrated with a dynamic tip clearance model. A parametric study was performed in an attempt to evaluate requirements for control actuators in terms of bandwidth, rate limits, saturation limits, and deadband. Constraints on the weight of the actuation system and some considerations as to the force which the actuator must be capable of exerting and maintaining are also investigated. From the results, the relevant range of the evaluated actuator parameters can be extracted. Some additional discussion is provided on the challenges posed by the tip clearance control problem and the implications for future small core aircraft engines.

  3. Side-Looking Airborne Radar (SLAR): A Tool for Introductory Physical Geography Courses.

    ERIC Educational Resources Information Center

    Richason, Benjamin F., Jr.

    1980-01-01

    Suggests how to use remote sensing techniques and data in geography courses in high school and college as well as in geography research. Tips are presented on using techniques such as topographic maps, vertical aerial photographs in stereo pairs, satellite images, and SLAR images (which are particularly useful in teaching landforms and…

  4. "At Sea": Reversibility in Teaching and Learning

    ERIC Educational Resources Information Center

    Cavicchi, Elizabeth Mary

    2018-01-01

    An equal-armed balance at equilibrium--the bar is horizontal--tips into disequilibrium upon displacing a weight. Equilibrium is restored by reversing that move--putting the weight back where it was, or doing the same on the other side. Piaget adopted the idea of equilibration to describe how the intellect, in relating to the world, develops.…

  5. Ten Tips for Teaching a Web Course

    ERIC Educational Resources Information Center

    D'Orsie, Sharon M.; Day, Karen

    2006-01-01

    Distance learning is a growing trend. There were an estimated 3,077,000 enrollments in all distance education courses offered by two- and four-year institutions in 2000-2001. A survey by the National Center for Educational Statistics revealed that in 2000-2001, 56 percent of two- and four-year degree-granting institutions offered some type of…

  6. The Tips, Tricks, and Challenges of Teaching Undergraduate Kinesiology Students Research Methodology through a Programmatic Lens

    ERIC Educational Resources Information Center

    Beller, Jennifer M.

    2013-01-01

    This article describes a programmatic approach to undergraduate research (UGR) at Washington State University. In a programmatic approach, UGR is woven throughout the curriculum, with the expressed intent of producing undergraduate students who have at least a moderate ability to read, use, conduct, and present research. Washington State…

  7. Fun While Showing, Not Telling: Crafting Vivid Detail in Writing

    ERIC Educational Resources Information Center

    Del Nero, Jennifer Renner

    2017-01-01

    This teaching tip highlights three writing minilessons that help students construct vivid sensory detail (textual detail related to the five senses) in their fiction and creative nonfiction writing. Learning to show, not tell, is a difficult task for novice writers. The author explores reasons why this is the case and provides directions for the…

  8. Problem-Solving Tools and Tips for School Leaders

    ERIC Educational Resources Information Center

    West, Cathie E.

    2011-01-01

    In this book, award-winning educator Cathie West teaches readers how to confidently prepare for and respond to the challenges that come with being a school leader. Derived from professional experience and extensive research, the strategies can be put to work exactly as described or adapted to fit the unique situations that educators face in their…

  9. Idea Bank: The Protein Résumé

    ERIC Educational Resources Information Center

    Caraballo, Tami; Crowther, Gregory

    2018-01-01

    The Idea Bank column provides tips and techniques for creative teaching, in about 1,000 words. As students use increasingly diverse internet sources, it becomes hard to tell whether their answers are truly original. A general solution to this dilemma is to ask students to present information in a format that they are unlikely to encounter in books…

  10. Every Word Is on Trial: Six-Word Memoirs in the Classroom

    ERIC Educational Resources Information Center

    Saunders, Jane M.; Smith, Emily E.

    2014-01-01

    Six-word memoirs are readily available through books, magazine articles, and on the Internet. This teaching tip explores how to use six-word memoirs to guide students through the writing process steps from developing and revising a concise memoir, to employing technology and imagery, to publishing final versions of their work online. Included in…

  11. Helping Adolescents with ADHD & Learning Disabilities: Ready-To-Use Tips, Techniques, and Checklists for School Success.

    ERIC Educational Resources Information Center

    Greenbaum, Judith; Markel, Geraldine

    This manual is intended to provide practical guidance to teachers of adolescents with attention deficit hyperactivity disorder (ADHD) and/or learning disabilities (LD) through specific techniques, teaching strategies, checklists, and student case histories. The 12 chapters address the following topics: (1) an overview of ADHD and LD including…

  12. Student Projects that Make a Meaningful and Lasting Contribution to Course Content

    ERIC Educational Resources Information Center

    Schmidt, Shelly J.

    2013-01-01

    The objective of this teaching tip is to share with others an idea of how to transform student projects from a dead-end process to a value-added end product, value-added end products that make a meaningful and lasting contribution to course content for use by future students. (Contains 2 tables.)

  13. Teaching Tip: Utilizing Classroom Simulation to Convey Key Concepts in IT Portfolio Management

    ERIC Educational Resources Information Center

    Larson, Eric C.

    2013-01-01

    Managing a portfolio of IT projects is an important capability for firms and their managers. The classroom simulation described here provides students in an MBA information systems management/strategy course with the opportunity to deepen their understanding of the key concepts that should be considered in managing an IT portfolio and helps…

  14. How To Make Presentations That Teach and Transform.

    ERIC Educational Resources Information Center

    Garmston, Robert J.; Wellman, Bruce M.

    A practical guide to designing and delivering interesting and effective presentations for adult audiences, this book covers the five stages of a presentation and offers tips for executing each one. The book discusses stage fright and how to use it, and it explores the use of macro maps for staying focused during presentations. The book also…

  15. The Big6 Collection: The Best of the Big6 Newsletter.

    ERIC Educational Resources Information Center

    Eisenberg, Michael B.; Berkowitz, Robert E.

    The Big6 is a complete approach to implementing meaningful learning and teaching of information and technology skills, essential for 21st century living. Including in-depth articles, practical tips, and explanations, this book offers a varied range of material about students and teachers, the Big6, and curriculum. The book is divided into 10 main…

  16. Restaurant Role-Play in Psychology

    ERIC Educational Resources Information Center

    Borya, Anthony

    2013-01-01

    Research methods is perceived as a technical and difficult topic by some students. Using role-play to teach it can make it more accessible, meaningful and engaging. Role-playing the familiar roles of customer and waiting staff at a restaurant and discussing the variables that may affect the size of tips can help students to learn some of the key…

  17. Developing English Learners' Reading Confidence with Whole-Class Repeated Reading

    ERIC Educational Resources Information Center

    Monobe, Gumiko; Bintz, William P.; McTeer, Janis S.

    2017-01-01

    This Teaching Tip describes how one second-grade teacher used whole-class repeated reading (WCRR) to promote social interaction and develop reading confidence with English learners (ELs). The authors share a brief review of professional literature on the challenges of ELs and the benefits of repeated reading and WCRR. The authors also provide…

  18. From Business Dining to Public Speaking: Tips for Acquiring Professional Presence and Its Role in the Business Curricula

    ERIC Educational Resources Information Center

    Bass, Anna Nicholson

    2010-01-01

    In today's dynamic business environment, organizations are beginning to realize the importance of teaching business etiquette, not only to enhance their corporate culture, but also to increase productivity and profitability. Corporations are providing opportunities for executives of today and business leaders of tomorrow to acquire these vital…

  19. Team Nutrition's Teacher Handbook: Tips, Tools, and Jewels for Busy Educators.

    ERIC Educational Resources Information Center

    Shepherd, Sandra K.; Whitehead, Constance S.

    This teacher support manual helps elementary educators teach proper nutrition to students in pre-K through grade 5. It provides a summary of all the background and tools teachers will need to do what they want with the Team Nutrition/Scholastic curricula. There is brief background information on nutrition basics; step-by-step instructions for…

  20. Targeted Management Tips to Enhance the Effectiveness of Tier 2, Guided Reading Instruction

    ERIC Educational Resources Information Center

    Marchand-Martella, Nancy E.; Martella, Ronald C.; Lambert, M. Charles

    2015-01-01

    Guided reading is a popular approach to teaching reading in today's schools. With the increase of schools and districts implementing response-to-intervention programs, guided reading can be easily enhanced to provide additional supports for students at risk for school failure who exhibit learning and behavioral challenges. This column offers…

  1. Work-Based Courses: Bringing College to the Production Line

    ERIC Educational Resources Information Center

    Kobes, Deborah; Girardi, Amy

    2016-01-01

    Work-based courses are an innovative way to bring college to the production line by using the job as a learning lab. This toolkit provides guidance to community college administrators and faculty who are interested in bringing a work-based course model to their college. It contains video content and teaching tips that introduce the six steps of…

  2. "Is That How I Really Sound?": Using iPads for Fluency Practice

    ERIC Educational Resources Information Center

    Ness, Molly

    2017-01-01

    This teaching tip showcases how students use iPads to video record themselves orally reading. In the Record, Listen, Reflect process, students conduct repeated readings with a familiar text, watch the recorded video, and conduct running records on themselves. Having an opportunity to watch videos of their own reading gives students a glimpse of…

  3. Teaching Tip: Using a Group Role-Play Exercise to Engage Students in Learning Business Processes and ERP

    ERIC Educational Resources Information Center

    Shen, Yide; Nicholson, Jennifer; Nicholson, Darren

    2015-01-01

    With the increasing process-centric focus and proliferation of Enterprise Resource Planning (ERP) systems in organizations, it is imperative for business graduates to understand cross-functional business processes and ERP system's role in supporting business processes. However, this topic can be rather abstract and dry to undergraduate students,…

  4. Field Trip to the Moon

    ERIC Educational Resources Information Center

    Lowman, Paul D., Jr.

    2004-01-01

    This article focuses on the geology of a single area of the Moon, the Imbrium Basin, and shows how geologists have combined basic geologic principles with evidence collected by the Apollo missions to learn more about the history of the Moon as a whole. In this article, the author discusses lunar geology teaching tips and mapping the Imbrium Basin…

  5. Diffusion of Impact Innovations to University Professors. A Final Report to the Exxon Education Foundation.

    ERIC Educational Resources Information Center

    Rogers, Everett M.; And Others

    Using four IMPACT innovations as examples (EXPER SIM, Guided Design, TIPS, and Student-to-Student Counseling), this study attempts to define the nature of technological and social changes in university teaching. Data were gathered in three phases: (1) a questionnaire was mailed to individuals who requested information; (2) the adopters of…

  6. Refining MARGINS Mini-Lessons Using Classroom Observations

    NASA Astrophysics Data System (ADS)

    Iverson, E. A.; Manduca, C. A.; McDaris, J. R.; Lee, S.

    2009-12-01

    One of the challenges that we face in developing teaching materials or activities from research findings is testing the materials to determine that they work as intended. Traditionally faculty develop material for their own class, notice what worked and didn’t, and improve them the next year. However, as we move to a community process of creating and sharing teaching materials, a community-based process for testing materials is appropriate. The MARGINS project has piloted such a process for testing teaching materials and activities developed as part of its mini-lesson project (http://serc.carleton.edu/margins/index.html). Building on prior work developing mechanisms for community review of teaching resources (e.g. Kastens, 2002; Hancock and Manduca, 2005; Mayhew and Hall, 2007), the MARGINS evaluation team developed a structured classroom observation protocol. The goals of field testing are to a) gather structured, consistent feedback for the lesson authors based on classroom use; b) guide reviewers of these lessons to reflect on research-based educational practice as a framework for their comments; c) collect information on the data and observations that the reviewer used to underpin their review; d) determine which mini-lessons are ready to be made widely available on the website. The protocol guides faculty observations on why they used the activity, the effectiveness of the activity in their classroom, the success of the activity in leading to the desired learning, and what other faculty need to successfully use the activity. Available online (http://serc.carleton.edu/margins/protocol.html), the protocol can be downloaded and completed during instruction with the activity. In order to encourage review of mini-lessons using the protocol, a workshop focused on review and revision of activities was held in May 2009. In preparation for the workshop, 13 of the 28 participants chose to field test a mini-lesson prior to the workshop and reported that they found this process instructive. Activity authors found the observations very helpful and the first mini-lessons have now been revised using feedback from testers. Initial results show that the tested mini-lessons give students hands-on experience with scientific data and help students make connections between geologic phenomena and data. Productive feedback ranged from suggestions for improving activity design, adaptations for other audiences, suggestions for clearer presentation, and tips for using the materials. The team plans to broaden the use of the protocol to test and refine all of the mini-lessons in the MARGINS collection.

  7. Mapping cavitation activity around dental ultrasonic tips.

    PubMed

    Walmsley, A Damien; Lea, Simon C; Felver, Bernhard; King, David C; Price, Gareth J

    2013-05-01

    Cavitation arising within the water around the oscillating ultrasonic scaler tip is an area that may lead to advances in enhancing biofilm removal. The aim of this study is to map the occurrence of cavitation around scaler tips under loaded conditions. Two designs of piezoelectric ultrasonic scaling probes were evaluated with a scanning laser vibrometer and luminol dosimetric system under loaded (100 g/200 g) and unloaded conditions. Loads were applied to the probe tips via teeth mounted in a load-measuring apparatus. There was a positive correlation between probe displacement amplitude and cavitation production for ultrasonic probes. The position of cavitation at the tip of each probe was greater under loaded conditions than unloaded and for the longer P probe towards the tip. Whilst increasing vibration displacement amplitude of ultrasonic scalers increases the occurrence of cavitation, factors such as the length of the probe influence the amount of cavitation activity generated. The application of load affects the production of cavitation at the most clinically relevant area-the tip. Loading and the design of ultrasonic scalers lead to maximising the occurrence of the cavitation at the tip and enhance the cleaning efficiency of the scaler.

  8. Automated scanning probe lithography with n-alkanethiol self assembled monolayers on Au(111): Application for teaching undergraduate laboratories

    PubMed Central

    Brown, Treva T.; LeJeune, Zorabel M.; Liu, Kai; Hardin, Sean; Li, Jie-Ren; Rupnik, Kresimir; Garno, Jayne C.

    2010-01-01

    Controllers for scanning probe instruments can be programmed for automated lithography to generate desired surface arrangements of nanopatterns of organic thin films, such as n-alkanethiol self-assembled monolayers (SAMs). In this report, atomic force microscopy (AFM) methods of lithography known as nanoshaving and nanografting are used to write nanopatterns within organic thin films. Commercial instruments provide software to control the length, direction, speed, and applied force of the scanning motion of the tip. For nanoshaving, higher forces are applied to an AFM tip to selectively remove regions of the matrix monolayer, exposing bare areas of the gold substrate. Nanografting is accomplished by force-induced displacement of molecules of a matrix SAM, followed immediately by the surface self-assembly of n-alkanethiol molecules from solution. Advancements in AFM automation enable rapid protocols for nanolithography, which can be accomplished within the tight time restraints of undergraduate laboratories. Example experiments with scanning probe lithography (SPL) will be described in this report that were accomplished by undergraduate students during laboratory course activities and research internships in the chemistry department of Louisiana State University. Students were introduced to principles of surface analysis and gained “hands-on” experience with nanoscale chemistry. PMID:21483651

  9. Twelve tips for the production of digital chalk-talk videos.

    PubMed

    Rana, Jasmine; Besche, Henrike; Cockrill, Barbara

    2017-06-01

    Increasingly over the past decade, faculty in medical and graduate schools have received requests from digital millennial learners for concise faculty-made educational videos. At our institution, over the past couple of years alone, several hundred educational videos have been created by faculty who teach in a flipped-classroom setting of the pre-clinical medical school curriculum. Despite the appeal and potential learning benefits of digital chalk-talk videos first popularized by Khan Academy, we have observed that the conceptual and technological barriers for creating chalk-talk videos can be high for faculty. To this end, this tips article offers an easy-to-follow 12-step conceptual framework to guide at-home production of chalk-talk educational videos.

  10. The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells.

    PubMed

    Kanamori, Mutsumi; Sandy, Peter; Marzinotto, Stefania; Benetti, Roberta; Kai, Chikatoshi; Hayashizaki, Yoshihide; Schneider, Claudio; Suzuki, Harukazu

    2003-10-03

    Wnt signaling is essential during development while deregulation of this pathway frequently leads to the formation of various tumors including colorectal carcinomas. A key component of the pathway is beta-catenin that, in association with TCF-4, directly regulates the expression of Wnt-responsive genes. To identify novel binding partners of beta-catenin that may control its transcriptional activity, we performed a mammalian two-hybrid screen and isolated the Tax-interacting protein (TIP-1). The in vivo complex formation between beta-catenin and TIP-1 was verified by coimmunoprecipitation, and a direct physical association was revealed by glutathione S-transferase pull-down experiments in vitro. By using a panel of deletion mutants of both proteins, we demonstrate that the interaction is mediated by the PDZ (PSD-95/DLG/ZO-1 homology) domain of TIP-1 and requires primarily the last four amino acids of beta-catenin. TIP-1 overexpression resulted in a dose-dependent decrease in the transcriptional activity of beta-catenin when tested on the TOP/FOPFLASH reporter system. Conversely, siRNA-mediated knock-down of endogenous TIP-1 slightly increased endogenous beta-catenin transactivation function. Moreover, we show that overexpression of TIP-1 reduced the proliferation and anchorage-independent growth of colorectal cancer cells. These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway.

  11. New Molecular Bridge between RelA/p65 and NF-κB Target Genes via Histone Acetyltransferase TIP60 Cofactor*

    PubMed Central

    Kim, Jung-Woong; Jang, Sang-Min; Kim, Chul-Hong; An, Joo-Hee; Kang, Eun-Jin; Choi, Kyung-Hee

    2012-01-01

    The nuclear factor-κB (NF-κB) family is involved in the expressions of numerous genes, in development, apoptosis, inflammatory responses, and oncogenesis. In this study we identified four NF-κB target genes that are modulated by TIP60. We also found that TIP60 interacts with the NF-κB RelA/p65 subunit and increases its transcriptional activity through protein-protein interaction. Although TIP60 binds with RelA/p65 using its histone acetyltransferase domain, TIP60 does not directly acetylate RelA/p65. However, TIP60 maintained acetylated Lys-310 RelA/p65 levels in the TNF-α-dependent NF-κB signaling pathway. In chromatin immunoprecipitation assay, TIP60 was primarily recruited to the IL-6, IL-8, C-IAP1, and XIAP promoters in TNF-α stimulation followed by acetylation of histones H3 and H4. Chromatin remodeling by TIP60 involved the sequential recruitment of acetyl-Lys-310 RelA/p65 to its target gene promoters. Furthermore, we showed that up-regulated TIP60 expression was correlated with acetyl-Lys-310 RelA/p65 expressions in hepatocarcinoma tissues. Taken together these results suggest that TIP60 is involved in the NF-κB pathway through protein interaction with RelA/p65 and that it modulates the transcriptional activity of RelA/p65 in NF-κB-dependent gene expression. PMID:22249179

  12. Crack-tips enriched platinum-copper superlattice nanoflakes as highly efficient anode electrocatalysts for direct methanol fuel cells.

    PubMed

    Zheng, Lijun; Yang, Dachi; Chang, Rong; Wang, Chengwen; Zhang, Gaixia; Sun, Shuhui

    2017-07-06

    We have developed "crack-tips" and "superlattice" enriched Pt-Cu nanoflakes (NFs), benefiting from the synergetic effects of "crack-tips" and "superlattice crystals"; the Pt-Cu NFs exhibit 4 times higher mass activity, 6 times higher specific activity and 6 times higher stability than those of the commercial Pt/C catalyst, respectively. Meanwhile, the Pt-Cu NFs show more enhanced CO tolerance than the commercial Pt/C catalyst.

  13. Long-term fertilization, but not warming, shifts rates of ectomycorrhizal nutrient cycling in Arctic tussock tundra.

    NASA Astrophysics Data System (ADS)

    Dunleavy, H.; Mack, M. C.

    2017-12-01

    The role of ectomycorrhizae (ECM) in Arctic nutrient cycling may be changing as temperature, nutrient availability, and ECM shrub abundance and size increase. A shift in ECM function has been proposed as a possible mechanism for shrub expansion. While several studies demonstrate a higher abundance of ECM as well as community compositional shifts in response to long-term experimental warming and fertilization, direct measurements of functional responses are missing. To understand the potential role of ECM in soil biogeochemical processes of the changing Arctic, we investigated the functional response of ECM to 30 years of summer warming and increased nutrient availability by measuring potential activities of extracellular enzymes associated with nitrogen (N) and phosphorous (P) acquisition on ECM root tips. We hypothesize ECM enzyme activities will be higher with warmer temperatures. Conversely, fertilization will lower ECM enzyme activities as N and P become less limiting to host plants. Preliminary results strongly support our latter hypothesis, but not the first. Warming decreased hydrolytic P-associated and labile N-associated enzyme activities on individual root tips (pmol/min/mm2 root tip) by 30% and 83%, respectively. However, warming increased ECM abundance and did not alter community-level activities (pmol/min/cm3 soil). Fertilization decreased hydrolytic and oxidative enzymatic activities on individual root tips by 34 to 80% as well as on a community level by 67 to 93%, even though ECM shrubs were almost monodominant. The combined effect of warming and fertilization decreased labile N-associated enzyme activity by 82%, but had little effect on oxidative and other hydrolytic enzyme activities. Although both warming and fertilization decreased root tip activities, reflecting a potential reduction in plant allocation to mycorrhizal nutrient acquisition, only fertilization lowered rates of ECM nutrient cycling. The indirect relationship between ECM abundance and individual root tip activity highlights the importance of measuring ECM function to assess the role of this symbiosis in nutrient cycling.

  14. Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair

    PubMed Central

    Sato, Emi; Zhang, Ling-juan; Dorschner, Robert A.; Adase, Christopher A.; Choudhury, Biswa P.; Gallo, Richard L.

    2018-01-01

    In this study, we report that TIP39, a parathyroid hormone ligand family member that was recently identified to be expressed in the skin, can induce decorin expression and enhance wound repair. Topical treatment of mice with TIP39 accelerated wound repair, whereas TIP39-deficient mice had delayed repair that was associated with formation of abnormal collagen bundles. To study the potential mechanism responsible for the action of TIP39 in the dermis, fibroblasts were cultured in three-dimensional collagen gels, a process that results in enhanced decorin expression unless activated to differentiate to adipocytes, whereupon these cells reduce expression of several proteoglycans, including decorin. Small interfering RNA-mediated silencing of parathyroid hormone 2 receptor (PTH2R), the receptor for TIP39, suppressed the expression of extracellular matrix-related genes, including decorin, collagens, fibronectin, and matrix metalloproteases. Skin wounds in TIP39−/− mice had decreased decorin expression, and addition of TIP39 to cultured fibroblasts induced decorin and increased phosphorylation and nuclear translocation of CREB. Fibroblasts differentiated to adipocytes and treated with TIP39 also showed increased decorin and production of chondroitin sulfate. Furthermore, the skin of PTH2R−/− mice showed abnormal extracellular matrix structure, decreased decorin expression, and skin hardness. Thus, the TIP39-PTH2R system appears to be a previously unrecognized mechanism for regulation of extracellular matrix formation and wound repair. PMID:28454729

  15. GeoMapApp Learning Activities: Grab-and-go inquiry-based geoscience activities that bring cutting-edge technology to the classroom

    NASA Astrophysics Data System (ADS)

    Goodwillie, A. M.; Kluge, S.

    2011-12-01

    NSF-funded GeoMapApp Learning Activities (http://serc.carleton.edu/geomapapp) provide self-contained learning opportunities that are centred around the principles of guided inquiry. The activities allow students to interact with and analyse research-quality geoscience data to explore and enhance student understanding of underlying geoscience content and concepts. Each activity offers ready-to-use step-by-step student instructions and answer sheets that can be downloaded from the web page. Also provided are annotated teacher versions of the worksheets that include teaching tips, additional content and suggestions for further work. Downloadable pre- and post- quizzes tied to each activity help educators gauge the learning progression of their students. Short multimedia tutorials and details on content alignment with state and national teaching standards round out the package of material that comprises each "grab-and-go" activity. GeoMapApp Learning Activities expose students to content and concepts typically found at the community college, high school and introductory undergraduate levels. The activities are based upon GeoMapApp (http://www.geomapapp.org), a free, easy-to-use map-based data exploration and visualisation tool that allows students to access a wide range of geoscience data sets in a virtual lab-like environment. Activities that have so far been created under this project include student exploration of seafloor spreading rates, a study of mass wasting as revealed through geomorphological evidence, and an analysis of plate motion and hotspot traces. The step-by-step instructions and guided inquiry approach lead students through each activity, thus reducing the need for teacher intervention whilst also boosting the time that students can spend on productive exploration and learning. The activities can be used, for example, in a classroom lab with the educator present and as self-paced assignments in an out-of-class setting. GeoMapApp Learning Activities are hosted on the SERC-Carleton web site.

  16. BIOLOGICAL SCIENCE TEACHING TIPS FROM TST, A COMPILATION OF ARTICLES FROM SEVEN YEARS OF THE SCIENCE TEACHER, 1960-1966.

    ERIC Educational Resources Information Center

    PORTER, T.R.

    SELECTED ARTICLES THAT APPEARED IN "THE SCIENCE TEACHER" DURING THE PERIOD 1960-1966 ARE INCLUDED IN THIS SUPPLEMENTARY REFERENCE FOR HIGH SCHOOL BIOLOGY TEACHERS. SUBDIVISIONS ARE (1) CONTENT BACKGROUND FOR TEACHERS, (2) CURRICULUM, AND (3) CLASSROOM IDEAS. CONTENT ARTICLES ARE PRIMARILY CONCERNED WITH THOSE ASPECTS OF BIOLOGY THAT ARE…

  17. "Hopping on the Tips of a Trident": Two Graduate Students of Color Reflect on Teaching Critical Content at Predominantly White Institutions

    ERIC Educational Resources Information Center

    Waring, Chandra D. L.; Bordoloi, Samit Dipon

    2012-01-01

    In this article, the authors capture the complexity of being a marginalized individual with institutional authority who encourages students to question all levels of power; simultaneously, they are acutely aware of the social implications of students challenging their authority, their intellectual aptitude, and their critical orientation. They…

  18. NAGWS Aquatics Guide: Tips and Techniques for Teachers and Coaches, August 1977-August 1979.

    ERIC Educational Resources Information Center

    Harris, Marjorie, Ed.

    This manual is designed to serve as a teaching aid to coaches and physical educators in the field of women's aquatics. The articles cover the following subjects in the area of water sports: (1) standards in sports for girls and women; (2) women in Olympic swimming competition; (3) conditioning programs designed to attain physical fitness through…

  19. Faculty Transitions in Online Delivery: Make or Buy? Tips for Developing a "New to You" Online Course

    ERIC Educational Resources Information Center

    Delaney-Klinger, Kelly; Vanevenhoven, Jeff; Wagner, Richard; Chenoweth, John

    2014-01-01

    In the last few decades, teaching courses online has become a standard practice at many colleges and universities. Although technologies and pedagogies have changed rapidly during this time, developing an online course is still a labor and time-intensive undertaking. With changes in staffing and course offerings, faculty are often faced with…

  20. K-12 Resources on the Internet PLUS: Instructor's Supplement. 2nd Edition.

    ERIC Educational Resources Information Center

    Junion-Metz, Gail

    This volume is a supplement to "K-12 Resources on the Internet: An Instructional Guide" and is intended for teaching trainers that prepare Internet workshops in schools and libraries. It includes the following materials: guidelines on how to use this supplement together with the Instructional Guide in preparing a workshop; tips on how to use the…

  1. JOB Soup for Women: 80 Job Bites You Can Sink Your Teeth into.

    ERIC Educational Resources Information Center

    Martin, Melissa

    Written for women by a career counselor, this resource guide provides proven job-search tips and teaches women about their personal job power. Its 80 job bites are divided into 10 chapters: "Choosing a Career & Evaluating a Job"; "Learn To Be an Assertive Woman at the Workplace"; "Portfolios, Resumes, Cover Letters, and Thank You Notes"; "Knowing…

  2. Games Children Play: How Games and Sport Help Children Develop.

    ERIC Educational Resources Information Center

    Brooking-Payne, Kim

    This book presents games for children, teenagers, and adults, explaining how each game can help children develop in a holistic way. It begins by discussing tips for teaching games, how to deal with children who break the rules, and what type of equipment to use. The book provides help on how to approach play within each of the different age…

  3. Teaching Tip: When a Matrix and Its Inverse Are Stochastic

    ERIC Educational Resources Information Center

    Ding, J.; Rhee, N. H.

    2013-01-01

    A stochastic matrix is a square matrix with nonnegative entries and row sums 1. The simplest example is a permutation matrix, whose rows permute the rows of an identity matrix. A permutation matrix and its inverse are both stochastic. We prove the converse, that is, if a matrix and its inverse are both stochastic, then it is a permutation matrix.

  4. Get Them Talking! Using Student-Led Book Talks in the Primary Grades

    ERIC Educational Resources Information Center

    Hudson, Alida K.

    2016-01-01

    This teaching tip details one teacher's implementation of student-led book talks in her primary-grade classroom. The author describes a simple gradual-release method that she has successfully used with her students in order to get them talking about the books that they are reading independently. She found that when used in the readers' workshop…

  5. The Freshman Nine: Helping High School Freshmen Be Successful in AP Human Geography

    ERIC Educational Resources Information Center

    Garner, Jennifer

    2012-01-01

    Teaching AP Human Geography to freshmen seems like a daunting task and while there are many arguments both for and against offering the course to freshmen, for many teachers it is reality. In this article, the author offers nine tips to help high school freshmen be successful in the course and on the AP exam.

  6. Teaching Tip: Improving Students' Email Communication through an Integrated Writing Assignment in a Third-Year Toxicology Course.

    PubMed

    Kedrowicz, April A; Hammond, Sarah; Dorman, David C

    Client communication is important for success in veterinary practice, with written communication being an important means for veterinarian-client information sharing. Effective communication is adapted to clients' needs and wants, and presents information in a clear, understandable manner while accounting for varying degrees of client health literacy. This teaching tip describes the use of a mock electronic mail assignment as one way to integrate writing into a required veterinary toxicology course. As part of this project, we provide baseline data relating to students' written communication that will guide further development of writing modules in other curricula. Two independent raters analyzed students' writing using a coding scheme designed to assess adherence to the guidelines for effective written health communication. Results showed that the majority of students performed satisfactorily or required some development with respect to recommended guidelines for effective written health communication to facilitate client understanding. These findings suggest that additional instruction and practice should emphasize the importance of incorporating examples, metaphors, analogies, and pictures to create texts that are comprehensible and memorable to clients. Recommendations are provided for effective integration of writing assignments into the veterinary medicine curriculum.

  7. Cellular functions of TIP60.

    PubMed

    Sapountzi, Vasileia; Logan, Ian R; Robson, Craig N

    2006-01-01

    TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated intensively. Recent data suggest that TIP60 has more divergent functions than originally thought and roles for TIP60 in many processes, such as cellular signalling, DNA damage repair, cell cycle and checkpoint control and apoptosis are emerging. TIP60 is a tightly regulated transcriptional coregulator, acting in a large multiprotein complex for a range of transcription factors including androgen receptor, Myc, STAT3, NF-kappaB, E2F1 and p53. This usually involves recruitment of TIP60 acetyltransferase activities to chromatin. Additionally, in response to DNA double strand breaks, TIP60 is recruited to DNA lesions where it participates both in the initial as well as the final stages of repair. Here, we describe how TIP60 is a multifunctional enzyme involved in multiple nuclear transactions.

  8. Test Rig for Active Turbine Blade Tip Clearance Control Concepts: An Update

    NASA Technical Reports Server (NTRS)

    Taylor, Shawn; Steinetz, Bruce; Oswald, Jay; DeCastro, Jonathan; Melcher, Kevin

    2006-01-01

    The objective is to develop and demonstrate a fast-acting active clearance control system to improve turbine engine performance, reduce emissions, and increase service life. System studies have shown the benefits of reducing blade tip clearances in modern turbine engines. Minimizing blade tip clearances throughout the engine will contribute materially to meeting NASA's Ultra-Efficient Engine Technology (UEET) turbine engine project goals. NASA GRC is examining two candidate approaches including rub-avoidance and regeneration which are explained in subsequent slides.

  9. Integrated Turbine Tip Clearance and Gas Turbine Engine Simulation

    NASA Technical Reports Server (NTRS)

    Chapman, Jeffryes W.; Kratz, Jonathan; Guo, Ten-Huei; Litt, Jonathan

    2016-01-01

    Gas turbine compressor and turbine blade tip clearance (i.e., the radial distance between the blade tip of an axial compressor or turbine and the containment structure) is a major contributing factor to gas path sealing, and can significantly affect engine efficiency and operational temperature. This paper details the creation of a generic but realistic high pressure turbine tip clearance model that may be used to facilitate active tip clearance control system research. This model uses a first principles approach to approximate thermal and mechanical deformations of the turbine system, taking into account the rotor, shroud, and blade tip components. Validation of the tip clearance model shows that the results are realistic and reflect values found in literature. In addition, this model has been integrated with a gas turbine engine simulation, creating a platform to explore engine performance as tip clearance is adjusted. Results from the integrated model explore the effects of tip clearance on engine operation and highlight advantages of tip clearance management.

  10. A tonoplast intrinsic protein in Gardenia jasminoides

    NASA Astrophysics Data System (ADS)

    Gao, Lan; Li, Hao-Ming

    2017-08-01

    Physiological and molecular studies proved that plasma membrane intrinsic proteins (PIPs) and tonoplast intrinsic proteins (TIPs) subfamily of aquaporins play key functions in plant water homeostasis. Five specialized subgroups (TIP1-5) of TIPs have been found in higher plants, in which the TIP1 and TIP2 isoforms are the largest arbitrary groups. TIPs have high water-transport activity than PIPs, some TIPs can transport other small molecule such as urea, ammonia, hydrogen peroxide, and carbon dioxide. In this work, the structure of the putative tonoplast aquaporin from Gardenia jasminoides (GjTIP) was analyzed. Its transcript level has increased during fruit maturation. A phylogenetic analysis indicates that the protein belongs to TIP1 subfamily. A three-dimensional model structure of GjTIP was built based on crystal structure of an ammonia-permeable AtTIP2-1 from Arabidopsis thaliana. The model structure displayed as a homo-tetramer, each monomer has six trans-membrane and two half-membrane-spanning α helices. The data suggests that the GjTIP has tendency to be a mixed function aquaporin, might involve in water, urea and hydrogen peroxide transport, and the gating machanism founded in some AQPs involving pH and phosphorylation response have not been proved in GjTIP.

  11. Changes in the Expression and the Enzymic Properties of the 20S Proteasome in Sugar-Starved Maize Roots. Evidence for an in Vivo Oxidation of the Proteasome1

    PubMed Central

    Basset , Gilles; Raymond, Philippe; Malek, Lada; Brouquisse, Renaud

    2002-01-01

    The 20S proteasome (multicatalytic proteinase) was purified from maize (Zea mays L. cv DEA 1992) roots through a five-step procedure. After biochemical characterization, it was shown to be similar to most eukaryotic proteasomes. We investigated the involvement of the 20S proteasome in the response to carbon starvation in excised maize root tips. Using polyclonal antibodies, we showed that the amount of proteasome increased in 24-h-carbon-starved root tips compared with freshly excised tips, whereas the mRNA levels of α3 and β6 subunits of 20S proteasome decreased. Moreover, in carbon-starved tissues, chymotrypsin-like and caseinolytic activities of the 20S proteasome were found to increase, whereas trypsin-like activities decreased. The measurement of specific activities and kinetic parameters of 20S proteasome purified from 24-h-starved root tips suggested that it was subjected to posttranslational modifications. Using dinitrophenylhydrazine, a carbonyl-specific reagent, we observed an increase in carbonyl residues in 20S proteasome purified from starved root tips. This means that 20S proteasome was oxidized during starvation treatment. Moreover, an in vitro mild oxidative treatment of 20S proteasome from non-starved material resulted in the activation of chymotrypsin-like, peptidyl-glutamyl-peptide hydrolase and caseinolytic-specific activities and in the inhibition of trypsin-like specific activities, similar to that observed for proteasome from starved root tips. Our results provide the first evidence, to our knowledge, for an in vivo carbonylation of the 20S proteasome. They suggest that sugar deprivation induces an oxidative stress, and that oxidized 20S proteasome could be associated to the degradation of oxidatively damaged proteins in carbon starvation situations. PMID:11891269

  12. 25-Gauge active aspiration silicon tip-assisted removal of glass and other intraocular foreign bodies.

    PubMed

    Singh, Ramandeep; Kumar, Abiraj; Gupta, Vishali; Dogra, Mangat R

    2016-04-01

    To describe the use of 25-gauge active aspiration silicon tip in removal of intraocular foreign bodies, including glass. Retrospective, noncomparative, interventional study. Eleven eyes of 11 patients who underwent the procedure between January 2013 and April 2015. The study included 10 males and 1 female with a mean age of 31.27 ± 9.64 years (range 12-45 years). All eyes in which 25-gauge active aspiration silicon tip-assisted removal of intraocular foreign body (IOFB) was done in a sutureless vitrectomy setup, irrespective of the nature of IOFB, were included. We excluded the participants with less than 6 months of postoperative follow-up. The primary outcome of the study was to assess the feasibility and reproducibility of 25-gauge active aspiration silicon tip-assisted removal of IOFB. The secondary outcome measures included change in best-corrected visual acuity (BCVA), and intraoperative and postoperative complications. There were iron (6), glass (2), wooden (1), pellet (1), and stone (1) IOFBs, for which 25-gauge active aspiration silicon tip-assisted removal was done successfully. The mean BCVA in Snellen's decimal equivalent improved significantly from 0.14 ± 0.16 to 0.34 ± 0.36 with a mean follow-up of 12 months (range 6-24 months). Intraoperatively, drop of IOFB because of loss of vacuum was observed in 2 eyes. Postoperatively, cystoid macular edema with epiretinal membrane was seen in 1 eye. There were no other intraoperative and postoperative complications. Use of 25-gauge active aspiration silicon tip to assist removal of magnetic and nonmagnetic IOFBs is a feasible and reproducible procedure, and required instrumentation is readily available in present-day vitrectomy era. Copyright © 2016 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  13. Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide

    NASA Astrophysics Data System (ADS)

    Chung, Chieh-Wen; Tsai, May-Jywan; Lin, Peng-Wei; Huang, Ding-Wen; Wang, Kuan-Hsun; Chen, Yu-An; Meng, Hsin-Fei; Zan, Hsiao-Wen; Cheng, Henrich; Tong, Limin; Zhang, Lei; Horng, Sheng-Fu; Hung, Cheng-Hsiung

    2018-02-01

    A NO sensing tip is made by inserting two parallel optical fibers inside a poly 2-hydroxyethyl methacrylate (PolyHEMA) hydrogel waveguide mixed with the probe molecule 1, 2-Diaminoanthraquinone (DAQ). There is a length difference of 1 mm between the two fibers, and the light has to propagate through the difference from the short fiber to the long fiber. The total cross section area of the active hydrogel waveguide embedded with the fibers is only 3mm x 1.2 mm. For practical use the tip is housed in a needle for mechanical protection and the sensing tip is able to detect aqueous NO concentration around 1 μM with time resolution about 5 minutes. Such a sensing tip can be used to monitor the medical conditions inside the brain after a stroke or a brain injury.

  14. DLESE Teaching Box Pilot Project: Developing a Replicable Model for Collaboratively Creating Innovative Instructional Sequences Using Exemplary Resources in the Digital Library for Earth System Education (DLESE)

    NASA Astrophysics Data System (ADS)

    Weingroff, M.

    2004-12-01

    Before the advent of digital libraries, it was difficult for teachers to find suitable high-quality resources to use in their teaching. Digital libraries such as DLESE have eased the task by making high quality resources more easily accessible and providing search mechanisms that allow teachers to 'fine tune' the criteria over which they search. Searches tend to return lists of resources with some contextualizing information. However, teachers who are teaching 'out of discipline' or who have minimal training in science often need additional support to know how to use and sequence them. The Teaching Box Pilot Project was developed to address these concerns, bringing together educators, scientists, and instructional designers in a partnership to build an online framework to fully support innovative units of instruction about the Earth system. Each box integrates DLESE resources and activities, teaching tips, standards, concepts, teaching outcomes, reviews, and assessment information. Online templates and best practice guidelines are being developed that will enable teachers to create their own boxes or customize existing ones. Two boxes have been developed so far, one on weather for high school students, and one on the evidence for plate tectonics for middle schoolers. The project has met with significant enthusiasm and interest, and we hope to expand it by involving individual teachers, school systems, pre-service programs, and universities in the development and use of teaching boxes. A key ingredient in the project's success has been the close collaboration between the partners, each of whom has brought unique experiences, perspectives, knowledge, and skills to the project. This first effort involved teachers in the San Francisco Bay area, the University of California Museum of Paleontology, San Francisco State University, U.S. Geological Survey, and DLESE. This poster will allow participants to explore one of the teaching boxes. We will discuss how the boxes were developed, the conditions that engendered successful collaboration and high-quality results, lessons learned, and potential adaptations for networks of user communities, for example, in ocean education or seismology.

  15. Endovascular Catheter for Magnetic Navigation under MR Imaging Guidance: Evaluation of Safety in Vivo at 1.5T

    PubMed Central

    Hetts, S.W.; Saeed, M.; Martin, A.J.; Evans, L.; Bernhardt, A.F.; Malba, V.; Settecase, F.; Do, L.; Yee, E.J.; Losey, A.; Sincic, R.; Roy, S.; Arenson, R.L.; Wilson, M.W.

    2013-01-01

    BACKGROUND AND PURPOSE: Endovascular navigation under MR imaging guidance can be facilitated by a catheter with steerable microcoils on the tip. Not only do microcoils create visible artifacts allowing catheter tracking, but also they create a small magnetic moment permitting remote-controlled catheter tip deflection. A side product of catheter tip electrical currents, however, is the heat that might damage blood vessels. We sought to determine the upper boundary of electrical currents safely usable at 1.5T in a coil-tipped microcatheter system. MATERIALS AND METHODS: Alumina tubes with solenoid copper coils were attached to neurovascular microcatheters with heat shrink-wrap. Catheters were tested in carotid arteries of 8 pigs. The catheters were advanced under x-ray fluoroscopy and MR imaging. Currents from 0 mA to 700 mA were applied to test heating and potential vascular damage. Postmortem histologic analysis was the primary endpoint. RESULTS: Several heat-mitigation strategies demonstrated negligible vascular damage compared with control arteries. Coil currents ≤300 mA resulted in no damage (0/58 samples) compared with 9 (25%) of 36 samples for > 300-mA activations (P = .0001). Tip coil activation ≤1 minute and a proximal carotid guide catheter saline drip > 2 mL/minute also had a nonsignificantly lower likelihood of vascular damage. For catheter tip coil activations ≤300 mA for ≤1 minute in normal carotid flow, 0 of 43 samples had tissue damage. CONCLUSIONS: Activations of copper coils at the tip of microcatheters at low currents in 1.5T MR scanners can be achieved without significant damage to blood vessel walls in a controlled experimental setting. Further optimization of catheter design and procedure protocols is necessary for safe remote control magnetic catheter guidance. PMID:23846795

  16. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex.

    PubMed

    Hwang, Jae-Ung; Vernoud, Vanessa; Szumlanski, Amy; Nielsen, Erik; Yang, Zhenbiao

    2008-12-23

    Highly elongated eukaryotic cells (e.g., neuronal axons, fungal hyphae, and pollen tubes) are generated through continuous apically restricted growth (tip growth), which universally requires tip-localized Rho GTPases. We used the oscillating pollen tube as a model system to determine the function and regulation of Rho GTPases in tip growth. Our previous work showed that the spatiotemporal dynamics of the apical cap of the activated Rho-like GTPase from Plant 1 (ROP1) are critical for tip growth in pollen tubes. However, the underlying mechanism for the generation and maintenance of this dynamic apical cap is poorly understood. A screen for mutations that enhance ROP1-overexpression-induced depolarization of pollen-tube growth identified REN1 (ROP1 enhancer 1) in Arabidopsis, whose null mutations turn elongated pollen tubes into bulbous cells. REN1 encodes a novel Rho GTPase-activating protein (RhoGAP) required for restricting the ROP1 activity to the pollen-tube tip. REN1 was localized to exocytic vesicles accumulated in the pollen-tube apex, as well as to the apical plasma membrane at the site of ROP1 activation. The apical localization of REN1 and its function in controlling growth polarity was compromised by disruption of ROP1-dependent F-actin and vesicular trafficking, which indicates that REN1 targeting and function is regulated by ROP1 downstream signaling. Our findings suggest that the REN1 RhoGAP controls a negative-feedback-based global inhibition of ROP1. This function provides a critical self-organizing mechanism, by which ROP signaling is spatially limited to the growth site and temporally oscillates during continuous tip growth. Similar spatiotemporal control of Rho GTPase signaling may also play an important role in cell-polarity control in other systems, including tip growth in fungi and cell movement in animals.

  17. Precepting 101: Teaching Strategies and Tips for Success for Preceptors.

    PubMed

    Lazarus, Judy

    2016-11-01

    The current shortage of certified nurse-midwives and certified midwives willing to serve as preceptors for midwifery education programs limits the number of students accepted into education programs. Preceptors are an essential link between academic programs and clinical practice and are indispensable to the growth of the midwifery profession. Preceptors create a safe environment for learning and teach adult learners through a variety of clinical teaching strategies. Novice preceptors need training and support to learn a new role, and experienced preceptors desire continued support and training. Before starting, preceptors need to identify sources of support and mentoring as well as understand the academic program's expectations for the student. This article draws on the clinical education literature to describe approaches to teaching all types of students. Practical strategies for integrating all levels of students into busy clinical settings are identified. Two approaches for clinical teaching, the Five Minute Preceptor and SNAPPS, are discussed in detail. Strategies for providing effective feedback and approaches to student evaluation are provided. © 2016 by the American College of Nurse-Midwives.

  18. Root Border Cells and Their Role in Plant Defense.

    PubMed

    Hawes, Martha; Allen, Caitilyn; Turgeon, B Gillian; Curlango-Rivera, Gilberto; Minh Tran, Tuan; Huskey, David A; Xiong, Zhongguo

    2016-08-04

    Root border cells separate from plant root tips and disperse into the soil environment. In most species, each root tip can produce thousands of metabolically active cells daily, with specialized patterns of gene expression. Their function has been an enduring mystery. Recent studies suggest that border cells operate in a manner similar to mammalian neutrophils: Both cell types export a complex of extracellular DNA (exDNA) and antimicrobial proteins that neutralize threats by trapping pathogens and thereby preventing invasion of host tissues. Extracellular DNases (exDNases) of pathogens promote virulence and systemic spread of the microbes. In plants, adding DNase I to root tips eliminates border cell extracellular traps and abolishes root tip resistance to infection. Mutation of genes encoding exDNase activity in plant-pathogenic bacteria (Ralstonia solanacearum) and fungi (Cochliobolus heterostrophus) results in reduced virulence. The study of exDNase activities in plant pathogens may yield new targets for disease control.

  19. Validation of mercury tip-switch and accelerometer activity sensors for identifying resting and active behavior in bears

    USGS Publications Warehouse

    Jasmine Ware,; Rode, Karyn D.; Pagano, Anthony M.; Bromaghin, Jeffrey F.; Robbins, Charles T.; Joy Erlenbach,; Shannon Jensen,; Amy Cutting,; Nicole Nicassio-Hiskey,; Amy Hash,; Owen, Megan A.; Heiko Jansen,

    2015-01-01

    Activity sensors are often included in wildlife transmitters and can provide information on the behavior and activity patterns of animals remotely. However, interpreting activity-sensor data relative to animal behavior can be difficult if animals cannot be continuously observed. In this study, we examined the performance of a mercury tip-switch and a tri-axial accelerometer housed in collars to determine whether sensor data can be accurately classified as resting and active behaviors and whether data are comparable for the 2 sensor types. Five captive bears (3 polar [Ursus maritimus] and 2 brown [U. arctos horribilis]) were fitted with a collar specially designed to internally house the sensors. The bears’ behaviors were recorded, classified, and then compared with sensor readings. A separate tri-axial accelerometer that sampled continuously at a higher frequency and provided raw acceleration values from 3 axes was also mounted on the collar to compare with the lower resolution sensors. Both accelerometers more accurately identified resting and active behaviors at time intervals ranging from 1 minute to 1 hour (≥91.1% accuracy) compared with the mercury tip-switch (range = 75.5–86.3%). However, mercury tip-switch accuracy improved when sampled at longer intervals (e.g., 30–60 min). Data from the lower resolution accelerometer, but not the mercury tip-switch, accurately predicted the percentage of time spent resting during an hour. Although the number of bears available for this study was small, our results suggest that these activity sensors can remotely identify resting versus active behaviors across most time intervals. We recommend that investigators consider both study objectives and the variation in accuracy of classifying resting and active behaviors reported here when determining sampling interval.

  20. The tonoplast intrinsic aquaporin (TIP) subfamily of Eucalyptus grandis: Characterization of EgTIP2, a root-specific and osmotic stress-responsive gene.

    PubMed

    Rodrigues, Marcela I; Bravo, Juliana P; Sassaki, Flávio T; Severino, Fábio E; Maia, Ivan G

    2013-12-01

    Aquaporins have important roles in various physiological processes in plants, including growth, development and adaptation to stress. In this study, a gene encoding a root-specific tonoplast intrinsic aquaporin (TIP) from Eucalyptus grandis (named EgTIP2) was investigated. The root-specific expression of EgTIP2 was validated over a panel of five eucalyptus organ/tissues. In eucalyptus roots, EgTIP2 expression was significantly induced by osmotic stress imposed by PEG treatment. Histochemical analysis of transgenic tobacco lines (Nicotiana tabacum SR1) harboring an EgTIP2 promoter:GUS reporter cassette revealed major GUS staining in the vasculature and in root tips. Consistent with its osmotic-stress inducible expression in eucalyptus, EgTIP2 promoter activity was up-regulated by mannitol treatment, but was down-regulated by abscisic acid. Taken together, these results suggest that EgTIP2 might be involved in eucalyptus response to drought. Additional searches in the eucalyptus genome revealed the presence of four additional putative TIP coding genes, which could be individually assigned to the classical TIP1-5 groups. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  1. Make Celebrations Fun, Healthy, and Active: 10 Tips to Creating Healthy, Active Events

    MedlinePlus

    United States Department of Agriculture 10 tips Nutrition Education Series MyPlate MyWins Based on the Dietary Guidelines for Americans Make celebrations ... out some of the recipes on WhatsCooking.fns.usda.gov. 8 Keep it simple Have others participate ...

  2. Turbine blade tip clearance measurement using a skewed dual-beam fiber optic sensor

    NASA Astrophysics Data System (ADS)

    Ye, De-chao; Duan, Fa-jie; Guo, Hao-tian; Li, Yangzong; Wang, Kai

    2012-08-01

    Optimization and active control of the tip clearance of turbine blades has been identified as a key to improve fuel efficiency, reduce emission, and increase service life of the engine. However, reliable and real-time tip clearance measurement is difficult due to the adverse environmental conditions that are typically found in a turbine. We describe a dual-beam fiber optic measurement system that can measure the tip timing and tip clearance simultaneously. Because the tip timing information is used to calculate the tip clearance, the method is insensitive to the signal intensity variation caused by fluctuations in environmental conditions such as light source instability, contamination, and blade tip imperfection. The system was calibrated and tested using experimental rotors. The test results indicated a high resolution of 4.5 μm and measurement accuracy of ±20 μm over the rotation speed range of 2000 to 10,000 rpm.

  3. Materials for advanced turbine engines. Volume 1: Advanced blade tip seal system

    NASA Technical Reports Server (NTRS)

    Zelahy, J. W.; Fairbanks, N. P.

    1982-01-01

    Project 3, the subject of this technical report, was structured toward the successful engine demonstration of an improved-efficiency, long-life, tip-seal system for turbine blades. The advanced tip-seal system was designed to maintain close operating clearances between turbine blade tips and turbine shrouds and, at the same time, be resistant to environmental effects including high-temperature oxidation, hot corrosion, and thermal cycling. The turbine blade tip comprised an environmentally resistant, activated-diffussion-bonded, monocrystal superalloy combined with a thin layer of aluminium oxide abrasive particles entrapped in an electroplated NiCr matrix. The project established the tip design and joint location, characterized the single-crystal tip alloy and abrasive tip treatment, and established the manufacturing and quality-control plans required to fully process the blades. A total of 171 blades were fully manufactured, and 100 were endurance and performance engine-tested.

  4. Using the Same Problem with Different Techniques in Programming Assignments: An Empirical Study of Its Effectiveness

    ERIC Educational Resources Information Center

    Newby, Michael; Nguyen, ThuyUyen H.

    2010-01-01

    This paper examines the effectiveness of a technique that first appeared as a Teaching Tip in the Journal of Information Systems Education. In this approach the same problem is used in every programming assignment within a course, but the students are required to use different programming techniques. This approach was used in an intermediate C++…

  5. Moving from the Periphery to the Center of the Academy: Faculty Developers as Leaders of Change

    ERIC Educational Resources Information Center

    Dawson, Debra; Mighty, Joy; Britnell, Judy

    2010-01-01

    Faculty development units have been in existence in North American universities and colleges for more than forty years. The early faculty development units were typically led by a committee or a part-time director who focused on presenting teaching tips in short workshops. Over the years, the role of these centers gradually evolved as they became…

  6. Preparing Teachers for One-to-One: Ten Tips to Help Educators Working in Laptop Environments Thrive

    ERIC Educational Resources Information Center

    Riley, Sheila

    2007-01-01

    More districts are turning to one-to-one computing, which puts a laptop in the hands of every student. This ambitious undertaking can bring challenges when it comes to training teachers how to use the technology--and how to teach students to use it. In 2005, Springfield Public Schools in Springfield, Oregon, provided Apple laptops for 300 middle…

  7. Teaching Tip: Managing Software Engineering Student Teams Using Pellerin's 4-D System

    ERIC Educational Resources Information Center

    Doman, Marguerite; Besmer, Andrew; Olsen, Anne

    2015-01-01

    In this article, we discuss the use of Pellerin's Four Dimension Leadership System (4-D) as a way to manage teams in a classroom setting. Over a 5-year period, we used a modified version of the 4-D model to manage teams within a senior level Software Engineering capstone course. We found that this approach for team management in a classroom…

  8. 101 "Answers" for New Teachers and Their Mentors: Effective Teaching Tips for Daily Classroom Use. Second Edition

    ERIC Educational Resources Information Center

    Breaux, Annette L.

    2011-01-01

    The 2nd edition of this bestselling title features brand new strategies plus illustrations! Make sure your new teachers are ready for the realities of the classroom. Be confident that their mentors are focused and effective. Organized so new teachers can read it by themselves, this book can also be studied collaboratively with veteran teachers who…

  9. Teaching the Internet to Library Staff and Users: 10 Ready-To-Go Workshops That Work. Neal-Schuman NetGuide Series.

    ERIC Educational Resources Information Center

    Hollands, William D.

    This guide features 10 customizable, ready-to-run workshops for librarians wishing to establish or refine ongoing Internet training for staff members or patrons. Each workshop in the book includes an introduction, an objective, a timed lesson plan, tips, a sample script, and reproducible handouts. In order to provide for the variety of settings…

  10. Helping Your Child Learn Math: Math Tips for Parents

    ERIC Educational Resources Information Center

    Nebraska Department of Education, 2010

    2010-01-01

    This paper presents tips, activities, resources, and games that parents can use to help their children become more proficient in math. Some helpful tips offered are: (1) Be positive; (2) Play family games; (3) Avoid stereotypes; (4) Choose gifts that develop problem solving skills; (5) Expand your children's horizons; (6) Buy or borrow library…

  11. Online monitoring of dynamic tip clearance of turbine blades in high temperature environments

    NASA Astrophysics Data System (ADS)

    Han, Yu; Zhong, Chong; Zhu, Xiaoliang; Zhe, Jiang

    2018-04-01

    Minimized tip clearance reduces the gas leakage over turbine blade tips and improves the thrust and efficiency of turbomachinery. An accurate tip clearance sensor, measuring the dynamic clearances between blade tips and the turbine case, is a critical component for tip clearance control. This paper presents a robust inductive tip clearance sensor capable of monitoring dynamic tip clearances of turbine machines in high-temperature environments and at high rotational speeds. The sensor can also self-sense the temperature at a blade tip in situ such that temperature effect on tip clearance measurement can be estimated and compensated. To evaluate the sensor’s performance, the sensor was tested for measuring the tip clearances of turbine blades under various working temperatures ranging from 700 K to 1300 K and at turbine rotational speeds ranging from 3000 to 10 000 rpm. The blade tip clearance was varied from 50 to 2000 µm. The experiment results proved that the sensor can accurately measure the blade tip clearances with a temporal resolution of 10 µm. The capability of accurately measuring the tip clearances at high temperatures (~1300 K) and high turbine rotation speeds (~30 000 rpm), along with its compact size, makes it promising for online monitoring and active control of blade tip clearances of high-temperature turbomachinery.

  12. JobTIPS: A Transition to Employment Program for Individuals with Autism Spectrum Disorders

    PubMed Central

    Strickland, Dorothy C.; Coles, Claire D.; Southern, Louise B.

    2013-01-01

    This study evaluated the effectiveness of an Internet accessed training program that included Theory of Mind-based guidance, video models, visual supports, and virtual reality practice sessions in teaching appropriate job interview skills to individuals with high functioning ASD. In a randomized study, twenty two youth, ages 16 to 19, were evaluated during two employment interviews. Half received a training intervention following the initial interview and the half who served as a contrast group did not. Their performance pre and post intervention was assessed by four independent raters using a scale that included evaluation of both Content and Delivery. Results suggest that youth who completed the JobTIPS employment program demonstrated significantly more effective verbal content skills than those who did not. PMID:23494559

  13. 25 tips for working through language and cultural barriers in your medical practice.

    PubMed

    Hills, Laura Sachs

    2009-01-01

    The language and cultural barriers facing medical patients with limited English language proficiency pose tremendous challenges and risks. Moreover, medical practices today are more likely than ever to employ individuals whose first language is not English or who do not possess native-like knowledge of American culture. Knowing how to work through the language and cultural barriers you are likely to encounter in your medical practice has become increasingly more important. This article is written by a practice management consultant who has graduate-level linguistics training and second-language teaching credentials and experience. It offers 25 practical tips to help you communicate more effectively with individuals who are outside of your native culture and language. These include easy-to-implement tips about English language pronunciation, grammar, and word choice. This article also suggests what you can do personally to bridge the cultural divide with your patients and co-workers. Finally, this article includes a case study of one Virginia practice in which cultural differences interfered with the practice's smooth operation. It explains how the practice eventually worked through and overcame this cultural obstacle.

  14. Microtubule plus-end tracking of end-binding protein 1 (EB1) is regulated by CDK5 regulatory subunit-associated protein 2

    PubMed Central

    Fong, Ka-Wing; Au, Franco K. C.; Jia, Yue; Yang, Shaozhong; Zhou, Liying; Qi, Robert Z.

    2017-01-01

    Microtubules are polar cytoskeleton filaments that extend via growth at their plus ends. Microtubule plus-end-tracking proteins (+TIPs) accumulate at these growing plus ends to control microtubule dynamics and attachment. The +TIP end-binding protein 1 (EB1) and its homologs possess an autonomous plus-end-tracking mechanism and interact with other known +TIPs, which then recruit those +TIPs to the growing plus ends. A major +TIP class contains the SXIP (Ser-X-Ile-Pro, with X denoting any amino acid residue) motif, known to interact with EB1 and its homologs for plus-end tracking, but the role of SXIP in regulating EB1 activities is unclear. We show here that an interaction of EB1 with the SXIP-containing +TIP CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) regulates several EB1 activities, including microtubule plus-end tracking, dynamics at microtubule plus ends, microtubule and α/β-tubulin binding, and microtubule polymerization. The SXIP motif fused with a dimerization domain from CDK5RAP2 significantly enhanced EB1 plus-end-tracking and microtubule-polymerizing and bundling activities, but the SXIP motif alone failed to do so. An SXIP-binding-deficient EB1 mutant displayed significantly lower microtubule plus-end tracking than the wild-type protein in transfected cells. These results suggest that EB1 cooperates with CDK5RAP2 and perhaps other SXIP-containing +TIPs in tracking growing microtubule tips. We also generated plus-end-tracking chimeras of CDK5RAP2 and the adenomatous polyposis coli protein (APC) and found that overexpression of the dimerization domains interfered with microtubule plus-end tracking of their respective SXIP-containing chimeras. Our results suggest that disruption of SXIP dimerization enables detailed investigations of microtubule plus-end-associated functions of individual SXIP-containing +TIPs. PMID:28320860

  15. A Hybrid Reality Radiation-free Simulator for Teaching Wire Navigation Skills

    PubMed Central

    Kho, Jenniefer Y.; Johns, Brian D.; Thomas, Geb. W.; Karam, Matthew D.; Marsh, J. Lawrence; Anderson, Donald D.

    2016-01-01

    Objectives Surgical simulation is an increasingly important method to facilitate the acquiring of surgical skills. Simulation can be helpful in developing hip fracture fixation skills because it is a common procedure for which performance can be objectively assessed (i.e., the tip-apex distance). The procedure requires fluoroscopic guidance to drill a wire along an osseous trajectory to a precise position within bone. The objective of this study was to assess the construct validity for a novel radiation-free simulator designed to teach wire navigation skills in hip fracture fixation. Methods Novices (N=30) with limited to no surgical experience in hip fracture fixation and experienced surgeons (N=10) participated. Participants drilled a guide wire in the center-center position of a synthetic femoral head in a hip fracture simulator, using electromagnetic sensors to track the guide wire position. Sensor data were gathered to generate fluoroscopic-like images of the hip and guide wire. Simulator performance of novice and experienced participants was compared to measure construct validity. Results The simulator was able to discriminate the accuracy in guide wire position between novices and experienced surgeons. Experienced surgeons achieved a more accurate tip-apex distance than novices (13 vs 23 mm, respectively, p=0.009). The magnitude of improvement on successive simulator attempts was dependent on level of expertise; tip-apex distance improved significantly in the novice group, while it was unchanged in the experienced group. Conclusions This hybrid reality, radiation-free hip fracture simulator, which combines real-world objects with computer-generated imagery demonstrates construct validity by distinguishing the performance of novices and experienced surgeons. There is a differential effect depending on level of experience, and it could be used as an effective training tool in novice surgeons. PMID:26165262

  16. Selected advanced aerodynamics and active controls technology concepts development on a derivative B-747 aircraft

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Analytical design and wind tunnel test evaluations covering the feasibility of applying wing tip extensions, winglets, and active control wing had alleviation to the model B747 are described. Aerodynamic improvement offered by wing tip extension and winglet individually, and the combined aerodynamic and weight improvements when wing load alleviation is combined with the tip extension or the winglet are evaluated. Results are presented in the form of incremental effects on weight mission range, fuel usage, cost, and airline operating economics.

  17. Redox competition mode of scanning electrochemical microscopy (RC-SECM) for visualisation of local catalytic activity.

    PubMed

    Eckhard, Kathrin; Chen, Xingxing; Turcu, Florin; Schuhmann, Wolfgang

    2006-12-07

    In order to locally analyse catalytic activity on modified surfaces a transient redox competition mode of scanning electrochemical microscopy (SECM) has been developed. In a bi-potentiostatic experiment the SECM tip competes with the sample for the very same analyte. This leads to a current decrease at the SECM tip, if it is positioned in close proximity to an active catalyst site on the surface. Specifically, local catalytic activity of a Pt-catalyst modified sample with respect to the catalytic reduction of molecular oxygen was investigated. At higher local catalytic activity the local 02 partial pressure within the gap between accurately positioned SECM tip and sample is depleted, leading to a noticeable tip current decrease over active sites. A flexible software module has been implemented into the SECM to adapt the competition conditions by proper definition of tip and sample potentials. A potential pulse profile enables the localised electrochemically induced generation of molecular oxygen prior to the competition detection. The current decay curves are recorded over the entire duration of the applied reduction pulse. Hence, a time resolved processing of the acquired current values provides movies of the local oxygen concentration against x,y-position. The SECM redox competition mode was verified with a macroscopic Pt-disk electrode as a test sample to demonstrate the feasibility of the approach. Moreover, highly dispersed electro-deposited spots of gold and platinum on glassy carbon were visualised using the redox competition mode of SECM. Catalyst spots of different nature as well as activity inhomogeneities within one spot caused by local variations in Pt-loading were visualised successfully.

  18. Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.

    PubMed

    Xu, Songjun; Wilf, Rona; Menon, Trisha; Panikker, Priyalakshmi; Sarthi, Jessica; Elefant, Felice

    2014-12-01

    Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive impairment that is a debilitating hallmark of most neurodegenerative disorders, including Alzheimer's disease (AD). Histone acetylation is one of the best characterized of these epigenetic mechanisms that is critical for regulating learning- and memory- associated gene expression profiles, yet the specific histone acetyltransferases (HATs) that mediate these effects have yet to be fully characterized. Here, we investigate an epigenetic role for the HAT Tip60 in learning and memory formation using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that Tip60 is endogenously expressed in the Kenyon cells, the intrinsic neurons of the MB, and in the MB axonal lobes. Targeted loss of Tip60 HAT activity in the MB causes thinner and shorter axonal lobes while increasing Tip60 HAT levels cause no morphological defects. Functional consequences of both loss and gain of Tip60 HAT levels in the MB are evidenced by defects in immediate-recall memory. Our ChIP-Seq analysis reveals that Tip60 target genes are enriched for functions in cognitive processes, and, accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, we find that both learning and immediate-recall memory deficits that occur under AD-associated, amyloid precursor protein (APP)-induced neurodegenerative conditions can be effectively rescued by increasing Tip60 HAT levels specifically in the MB. Together, our findings uncover an epigenetic transcriptional regulatory role for Tip60 in cognitive function and highlight the potential of HAT activators as a therapeutic option for neurodegenerative disorders. Copyright © 2014 by the Genetics Society of America.

  19. Tips for Breastfeeding Moms

    MedlinePlus

    United States Department of Agriculture Tips for Breastfeeding Moms Making healthy food choices along with regular physical activity will keep you healthy while you breastfeed. Find Your Healthy Eating Style Choose ...

  20. Defining toxicological tipping points in neuronal network development.

    PubMed

    Frank, Christopher L; Brown, Jasmine P; Wallace, Kathleen; Wambaugh, John F; Shah, Imran; Shafer, Timothy J

    2018-02-02

    Measuring electrical activity of neural networks by microelectrode array (MEA) has recently shown promise for screening level assessments of chemical toxicity on network development and function. Important aspects of interneuronal communication can be quantified from a single MEA recording, including individual firing rates, coordinated bursting, and measures of network synchrony, providing rich datasets to evaluate chemical effects. Further, multiple recordings can be made from the same network, including during the formation of these networks in vitro. The ability to perform multiple recording sessions over the in vitro development of network activity may provide further insight into developmental effects of neurotoxicants. In the current study, a recently described MEA-based screen of 86 compounds in primary rat cortical cultures over 12 days in vitro was revisited to establish a framework that integrates all available primary measures of electrical activity from MEA recordings into a composite metric for deviation from normal activity (total scalar perturbation). Examining scalar perturbations over time and increasing concentration of compound allowed for definition of critical concentrations or "tipping points" at which the neural networks switched from recovery to non-recovery trajectories for 42 compounds. These tipping point concentrations occurred at predominantly lower concentrations than those causing overt cell viability loss or disrupting individual network parameters, suggesting tipping points may be a more sensitive measure of network functional loss. Comparing tipping points for six compounds with plasma concentrations known to cause developmental neurotoxicity in vivo demonstrated strong concordance and suggests there is potential for using tipping points for chemical prioritization. Published by Elsevier Inc.

  1. Health and Family Living. Teacher Guidebook and Student Activity Book. Adult Basic Education Project REAL: Relevant Education for Adult Learners.

    ERIC Educational Resources Information Center

    Edgar, S. Keith

    This packet contains both a teacher's guide and a student activity book designed to help adult students learn about health and family living. Both booklets cover the following topics: health in the home, safety in the home (safety tips concerning children, tips on indoor safety, first aid), helping children with school activities, leisure time and…

  2. Twelve tips on setting up and running a peer-led medical education society.

    PubMed

    Fleming-Nouri, Alex; Crocombe, Dominic; Sammaraiee, Yezen

    2016-12-01

    Peer-led teaching is an established paradigm with benefits for student teachers, learners and the wider medical community. Students are increasingly taking ownership of such teaching, which has fuelled the creation of new peer-led medical education societies at universities around the UK. Students wishing to undertake such an endeavor must contend with concerns over the quality of peer-led teaching, logistical challenges, lack of senior support and difficulties accessing relevant resources to design and appraise their initiatives. Peer-led medical education societies represent a relatively novel concept, and students may struggle to find practical information on how to approach these challenges. We propose that these obstacles can be overcome by thorough event planning, understanding the role and features of high quality peer-led education in supplementing medical school curricula, maintaining a strong working relationship with local medical faculty, and learning from the wider medical education community.

  3. The risk of capsular breakage from phacoemulsification needle contact with the lens capsule: a laboratory study.

    PubMed

    Meyer, Jay J; Kuo, Annie F; Olson, Randall J

    2010-06-01

    To determine capsular breakage risk from contact by phacoemulsification needles by machine and tip type. Experimental laboratory investigation. Infiniti (Alcon, Inc.) with Intrepid cartridges and Signature (Abbott Medical Optics, Inc.) phacoemulsification machines were tested using 19- and 20-gauge sharp and rounded tips. Actual and unoccluded flow vacuum were determined at 550 mm Hg, bottle height of 75 cm, and machine-indicated flow rate of 60 mL/minute. Breakage from brief tip contact with a capsular surrogate and human cadaveric lenses was calculated. Nineteen-gauge tips had more flow and less unoccluded flow vacuum than 20-gauge tips for both machines, with highest unoccluded flow vacuum in the Infiniti. The 19-gauge sharp tip was more likely than the 20-gauge sharp tip to cause surrogate breakage for Signature with micropulse and Ellips (Abbott Medical Optics, Inc.) ultrasound at 100% power. For Infiniti using OZil (Alcon, Inc.) ultrasound, 20-gauge sharp tips were more likely than 19-gauge sharp tips to break the membrane. For cadaveric lenses, using rounded 20-gauge tips at 100% power, breakage rates were micropulse (2.3%), Ellips (2.3%), OZil (5.3%). Breakage rates for sharp 20-gauge Ellips tips were higher than for rounded tips. Factors influencing capsular breakage may include active vacuum at the tip, flow rate, needle gauge, and sharpness. Nineteen-gauge sharp tips were more likely than 20-gauge tips to cause breakage in lower vacuum methods. For higher-vacuum methods, breakage is more likely with 20-gauge than with 19-gauge tips. Rounded-edge tips are less likely than sharp-edged tips to cause breakage. Copyright 2010 Elsevier Inc. All rights reserved.

  4. NASA Science Mission Directorate Forum Support of Scientists and Engineers to Engage in Education and Outreach

    NASA Astrophysics Data System (ADS)

    Buxner, S.; Grier, J.; Meinke, B. K.; Schneider, N. M.; Low, R.; Schultz, G. R.; Manning, J. G.; Fraknoi, A.; Gross, N. A.; Shipp, S. S.

    2015-12-01

    For the past six years, the NASA Science Education and Public Outreach (E/PO) Forums have supported the NASA Science Mission Directorate (SMD) and its E/PO community by enhancing the coherency and efficiency of SMD-funded E/PO programs. The Forums have fostered collaboration and partnerships between scientists with content expertise and educators with pedagogy expertise. As part of this work, in collaboration with the AAS Division of Planetary Sciences, we have interviewed SMD scientists, and more recently engineers, to understand their needs, barriers, attitudes, and understanding of education and outreach work. Respondents told us that they needed additional resources and professional development to support their work in education and outreach, including information about how to get started, ways to improve their communication, and strategies and activities for their teaching and outreach. In response, the Forums have developed and made available a suite of tools to support scientists and engineers in their E/PO efforts. These include "getting started" guides, "tips and tricks" for engaging in E/PO, vetted lists of classroom and outreach activities, and resources for college classrooms. NASA Wavelength (http://nasawavelength.org/), an online repository of SMD funded activities that have been reviewed by both educators and scientists for quality and accuracy, provides a searchable database of resources for teaching as well as ready-made lists by topic and education level, including lists for introductory college classrooms. Additionally, we have also supported scientists at professional conferences through organizing oral and poster sessions, networking activities, E/PO helpdesks, professional development workshops, and support for students and early careers scientists. For more information and to access resources for scientists and engineers, visit http://smdepo.org.

  5. Imaging contrast and tip-sample interaction of non-contact amplitude modulation atomic force microscopy with Q-control

    NASA Astrophysics Data System (ADS)

    Shi, Shuai; Guo, Dan; Luo, Jianbin

    2017-10-01

    Active quality factor (Q) exhibits many promising properties in dynamic atomic force microscopy. Energy dissipation and image contrasts are investigated in the non-contact amplitude modulation atomic force microscopy (AM-AFM) with an active Q-control circuit in the ambient air environment. Dissipated power and virial were calculated to compare the highly nonlinear interaction of tip-sample and image contrasts with different Q gain values. Greater free amplitudes and lower effective Q values show better contrasts for the same setpoint ratio. Active quality factor also can be employed to change tip-sample interaction force in non-contact regime. It is meaningful that non-destructive and better contrast images can be realized in non-contact AM-AFM by applying an active Q-control to the dynamic system.

  6. Generic Transport Mechanisms for Molecular Traffic in Cellular Protrusions

    NASA Astrophysics Data System (ADS)

    Graf, Isabella R.; Frey, Erwin

    2017-03-01

    Transport of molecular motors along protein filaments in a half-closed geometry is a common feature of biologically relevant processes in cellular protrusions. Using a lattice-gas model we study how the interplay between active and diffusive transport and mass conservation leads to localized domain walls and tip localization of the motors. We identify a mechanism for task sharing between the active motors (maintaining a gradient) and the diffusive motion (transport to the tip), which ensures that energy consumption is low and motor exchange mostly happens at the tip. These features are attributed to strong nearest-neighbor correlations that lead to a strong reduction of active currents, which we calculate analytically using an exact moment identity, and might prove useful for the understanding of correlations and active transport also in more elaborate systems.

  7. Helping Students with Autism Spectrum Disorder Express Their Thoughts and Knowledge in Writing: Tips and Exercises for Developing Writing Skills

    ERIC Educational Resources Information Center

    Geither, Elise; Meeks, Lisa

    2014-01-01

    When it comes to academic work, students with Autism Spectrum Disorder (ASD) often have the required knowledge but struggle to get their thoughts down in writing. This is a practical guide to teaching and improving writing skills in students with ASD to meet academic writing standards and prepare for the increased expectations of higher education.…

  8. "The Power of Our Words and Flesh": An Experienced Literacy Coach's Love Letter to Incoming Educators about the Transformational Roles of Relationships and the Body in Learning

    ERIC Educational Resources Information Center

    Woodcock, Christine; Hakeem, Phyllis

    2015-01-01

    Framed by the importance of language, and the ways that knowledge is embodied, this study explores the "coaching side" of literacy coaching, providing tips to educators. Phyllis, an experienced coach nearing retirement, wanted to provide insights to incoming teachers as she reflected on the question "Why 'do' we teach, anyway?"…

  9. Teaching Surgical Procedures with Movies: Tips for High-quality Video Clips.

    PubMed

    Jacquemart, Mathieu; Bouletreau, Pierre; Breton, Pierre; Mojallal, Ali; Sigaux, Nicolas

    2016-09-01

    Video must now be considered as a precious tool for learning surgery. However, the medium does present production challenges, and currently, quality movies are not always accessible. We developed a series of 7 surgical videos and made them available on a publicly accessible internet website. Our videos have been viewed by thousands of people worldwide. High-quality educational movies must respect strategic and technical points to be reliable.

  10. Integrating Systems Thinking Into Nursing Education.

    PubMed

    Phillips, Janet M; Stalter, Ann M

    2016-09-01

    A critical need exists for nursing leadership in current complex health care settings. Systems thinking can be incorporated into nursing education at all levels by using evidence-based principles in education. Teaching tips are provided using a systems awareness model to guide nurse educators in the assessment and integration of systems thinking and engaging learners in interprofessional education and practice. J Contin Educ Nurs. 2016;47(9):395-397. Copyright 2016, SLACK Incorporated.

  11. Balloon-Occluded Retrograde Transvenous Obliteration of Gastric Varices: Concept, Basic Techniques, and Outcomes

    PubMed Central

    Saad, Wael E. A.

    2012-01-01

    Patients with gastric variceal bleeding require a multidisciplinary team approach including hepatologists, endoscopists, diagnostic radiologists, and interventional radiologists. Upper gastrointestinal endoscopy is the first-line diagnostic and management tool for bleeding gastric varices, as it is in all upper gastrointestinal bleeding scenarios. In the United States when endoscopy fails to control gastric variceal bleeding, a transjugular intrahepatic portosystemic shunt (TIPS) traditionally is performed along the classic teachings of decompressing the portal circulation. However, TIPS has not shown the same effectiveness in controlling gastric variceal bleeding that it has with esophageal variceal bleeding. For the past 2 decades, the balloon-occluded retrograde transvenous obliteration (BRTO) procedure has become common practice in Asia for the management of gastric varices. BRTO is gaining popularity in the United States. It has been shown to be effective in controlling gastric variceal bleeding with low rebleed rates. BRTO has many advantages over TIPS in that it is less invasive and can be performed on patients with poor hepatic reserve and those with encephalopathy (and may even improve both). However, its by-product is occlusion of a spontaneous hepatofugal (TIPS equivalent) shunt, and thus it is contradictory to the traditional American doctrine of portal decompression. Indeed, BRTO causes an increase in portal hypertension, with potential aggravation of esophageal varices and ascites. This article discusses the concept, technique, and outcomes of BRTO within the broader management of gastric varices. PMID:23729982

  12. Epigenetic Regulation of Axonal Growth of Drosophila Pacemaker Cells by Histone Acetyltransferase Tip60 Controls Sleep

    PubMed Central

    Pirooznia, Sheila K.; Chiu, Kellie; Chan, May T.; Zimmerman, John E.; Elefant, Felice

    2012-01-01

    Tip60 is a histone acetyltransferase (HAT) enzyme that epigenetically regulates genes enriched for neuronal functions through interaction with the amyloid precursor protein (APP) intracellular domain. However, whether Tip60-mediated epigenetic dysregulation affects specific neuronal processes in vivo and contributes to neurodegeneration remains unclear. Here, we show that Tip60 HAT activity mediates axonal growth of the Drosophila pacemaker cells, termed “small ventrolateral neurons” (sLNvs), and their production of the neuropeptide pigment-dispersing factor (PDF) that functions to stabilize Drosophila sleep–wake cycles. Using genetic approaches, we show that loss of Tip60 HAT activity in the presence of the Alzheimer’s disease-associated APP affects PDF expression and causes retraction of the sLNv synaptic arbor required for presynaptic release of PDF. Functional consequence of these effects is evidenced by disruption of the sleep–wake cycle in these flies. Notably, overexpression of Tip60 in conjunction with APP rescues these sleep–wake disturbances by inducing overelaboration of the sLNv synaptic terminals and increasing PDF levels, supporting a neuroprotective role for dTip60 in sLNv growth and function under APP-induced neurodegenerative conditions. Our findings reveal a novel mechanism for Tip60 mediated sleep–wake regulation via control of axonal growth and PDF levels within the sLNv-encompassing neural network and provide insight into epigenetic-based regulation of sleep disturbances observed in neurodegenerative diseases like Alzheimer’s disease. PMID:22982579

  13. A combined piezoelectric composite actuator and its application to wing/blade tips

    NASA Astrophysics Data System (ADS)

    Ha, Kwangtae

    A novel combined piezoelectric-composite actuator configuration is proposed and analytically modeled in this work. The actuator is a low complexity, active compliant mechanism obtained by coupling a modified star cross sectional configuration composite beam with a helicoidal bimorph piezoelectric actuator coiled around it. This novel actuator is a good candidate as a hinge tension-torsion bar actuator for a helicopter rotor blade flap or blade tip and mirror rotational positioning. In the wing tip case, the tip deflection angle is different only according to the aerodynamic moment depending on the hinge position of the actuator along the chord and applied voltage because there is no centrifugal force. For an active blade tip subject to incompressible flow and 2D quasi steady airloads, its twist angle is related not only to aerodynamic moment and applied voltage but also to coupling terms, such as the trapeze effect and the tennis racquet effect. Results show the benefit of hinge position aft of the aerodynamic center, such that the blade tip response is amplified by airloads. Contrary to this effect, results also show that the centrifugal effects and inertial effect cause an amplitude reduction in the response. Summation of these effects determines the overall blade tip response. The results for a certain hinge position of Xh=1.5% chord aft of the quarter chord point proves that the tip deflection target design range of beta ∈ [-2,+2] can be achieved for all pitch angle configurations chosen.

  14. Test Rig for Evaluating Active Turbine Blade Tip Clearance Control Concepts

    NASA Technical Reports Server (NTRS)

    Lattime, Scott B.; Steinetz, Bruce M.; Robbie, Malcolm G.

    2003-01-01

    Improved blade tip sealing in the high pressure compressor and high pressure turbine can provide dramatic improvements in specific fuel consumption, time-on-wing, compressor stall margin and engine efficiency as well as increased payload and mission range capabilities of both military and commercial gas turbine engines. The preliminary design of a mechanically actuated active clearance control (ACC) system for turbine blade tip clearance management is presented along with the design of a bench top test rig in which the system is to be evaluated. The ACC system utilizes mechanically actuated seal carrier segments and clearance measurement feedback to provide fast and precise active clearance control throughout engine operation. The purpose of this active clearance control system is to improve upon current case cooling methods. These systems have relatively slow response and do not use clearance measurement, thereby forcing cold build clearances to set the minimum clearances at extreme operating conditions (e.g., takeoff, re-burst) and not allowing cruise clearances to be minimized due to the possibility of throttle transients (e.g., step change in altitude). The active turbine blade tip clearance control system design presented herein will be evaluated to ensure that proper response and positional accuracy is achievable under simulated high-pressure turbine conditions. The test rig will simulate proper seal carrier pressure and temperature loading as well as the magnitudes and rates of blade tip clearance changes of an actual gas turbine engine. The results of these evaluations will be presented in future works.

  15. High Temperature Investigations into an Active Turbine Blade Tip Clearance Control Concept

    NASA Technical Reports Server (NTRS)

    Taylor, Shawn; Steinetz, Bruce M.; Oswald, Jay J.

    2007-01-01

    System studies have shown the benefits of reducing blade tip clearances in modern turbine engines. Minimizing blade tip clearances throughout the engine will contribute materially to meeting NASA s Ultra-Efficient Engine Technology (UEET) turbine engine project goals. NASA GRC is examining two candidate approaches including rub-avoidance and regeneration which are explained in subsequent slides.

  16. High Temperature Investigations into an Active Turbine Blade Tip Clearance Control Concept

    NASA Technical Reports Server (NTRS)

    Taylor, Shawn C.; Steinetz, Bruce; Oswald, Jay J.

    2008-01-01

    System studies have shown the benefits of reducing blade tip clearances in modern turbine engines. Minimizing blade tip clearances throughout the engine will contribute materially to meeting NASA s Ultra-Efficient Engine Technology (UEET) turbine engine project goals. NASA GRC is examining two candidate approaches including rub-avoidance and regeneration which are explained in subsequent slides.

  17. The Microtubule-Associated Protein MAP18 Affects ROP2 GTPase Activity during Root Hair Growth1[OPEN

    PubMed Central

    Kang, Erfang; Zheng, Mingzhi; Zhang, Yan; Yuan, Ming; Fu, Ying

    2017-01-01

    Establishment and maintenance of the polar site are important for root hair tip growth. We previously reported that Arabidopsis (Arabidopsis thaliana) MICROTUBULE-ASSOCIATED PROTEIN18 (MAP18) functions in controlling the direction of pollen tube growth and root hair elongation. Additionally, the Rop GTPase ROP2 was reported as a positive regulator of both root hair initiation and tip growth in Arabidopsis. Both loss of function of ROP2 and knockdown of MAP18 lead to a decrease in root hair length, whereas overexpression of either MAP18 or ROP2 causes multiple tips or a branching hair phenotype. However, it is unclear whether MAP18 and ROP2 coordinately regulate root hair growth. In this study, we demonstrate that MAP18 and ROP2 interact genetically and functionally. MAP18 interacts physically with ROP2 in vitro and in vivo and preferentially binds to the inactive form of the ROP2 protein. MAP18 promotes ROP2 activity during root hair tip growth. Further investigation revealed that MAP18 competes with RhoGTPase GDP DISSOCIATION INHIBITOR1/SUPERCENTIPEDE1 for binding to ROP2, in turn affecting the localization of active ROP2 in the plasma membrane of the root hair tip. These results reveal a novel function of MAP18 in the regulation of ROP2 activation during root hair growth. PMID:28314794

  18. Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dong, Wenjie, E-mail: dongwenjie200581@126.com; Shen, Ruizhe; Cheng, Shidan

    2014-10-31

    Highlights: • TIP30 expression is frequently suppressed in ESCC. • TIP30 was hypermethylated in ESCC. • Reduction of TIP30 was significantly correlated with LN metastasis. • miR-10b is a direct regulator of TIP30. - Abstract: TIP30 is a putative tumor suppressor that can promote apoptosis and inhibit angiogenesis. However, the role of TIP30 in esophageal squamous cell carcinoma (ESCC) biology has not been investigated. Immunohistochemistry was used to investigate the expression of TIP30 in 70 ESCC. Hypermethylation of TIP30 was evaluated by the methylation specific PCR (MSP) method in ESCC (tumor and paired adjacent non-tumor tissues). Lost expression of TIP30more » was observed in 50 of 70 (71.4%) ESCC. 61.4% (43 of 70) of primary tumors analyzed displayed TIP30 hypermethylation, indicating that this aberrant characteristic is common in ESCC. Moreover, a statistically significant inverse association was found between TIP30 methylation status and expression of the TIP30 protein in tumor tissues (p = 0.001). We also found that microRNA-10b (miR-10b) targets a homologous DNA region in the 3′untranslated region of the TIP30 gene and represses its expression at the transcriptional level. Reporter assay with 3′UTR of TIP30 cloned downstream of the luciferase gene showed reduced luciferase activity in the presence of miR-10b, providing strong evidence that miR-10b is a direct regulator of TIP30. These results suggest that TIP30 expression is regulated by promoter methylation and miR-10b in ESCC.« less

  19. Active Piezoelectric Structures for Tip Clearance Management Assessed

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Managing blade tip clearance in turbomachinery stages is critical to developing advanced subsonic propulsion systems. Active casing structures with embedded piezoelectric actuators appear to be a promising solution. They can control static and dynamic tip clearance, compensate for uneven deflections, and accomplish electromechanical coupling at the material level. In addition, they have a compact design. To assess the feasibility of this concept and assist the development of these novel structures, the NASA Lewis Research Center developed in-house computational capabilities for composite structures with piezoelectric actuators and sensors, and subsequently used them to simulate candidate active casing structures. The simulations indicated the potential of active casings to modify the blade tip clearance enough to improve stage efficiency. They also provided valuable design information, such as preliminary actuator configurations (number and location) and the corresponding voltage patterns required to compensate for uneven casing deformations. An active ovalization of a casing with four discrete piezoceramic actuators attached on the outer surface is shown. The center figure shows the predicted radial displacements along the hoop direction that are induced when electrostatic voltage is applied at the piezoceramic actuators. This work, which has demonstrated the capabilities of in-house computational models to analyze and design active casing structures, is expected to contribute toward the development of advanced subsonic engines.

  20. Fitness: Tips for Staying Motivated

    MedlinePlus

    ... life. Review these tips whenever you feel your motivation slipping. Identifying your fitness goals. American Heart Association. ... prescription. Primary Care. 2013;40:801. Physical activity: Motivation. Centers for Disease Control and Prevention. http://www. ...

  1. Effect of tip radius on the incipient plasticity of chromium studied by nanoindentation

    DOE PAGES

    Wu, Dong; Morris, James R.; Nieh, T. G.

    2014-10-01

    The onset of plasticity in Cr was investigated by nanoindentation using indenters with tip radii ranging from 60 to 759 nm. The stress for incipient plasticity was found to increase with decreasing tip radius. We find that the cumulative pop-in probability on load could be described successfully by a combined model over the full range of tip radius, indicating that the incipient plasticity might be triggered either by the homogeneous nucleation of dislocation or by the activation of existing dislocations underneath the indenter.

  2. Nantucket pine tip moth, Rhyacionia Frustrana, lures and traps: What is the optimum combination?

    Treesearch

    Gary L. DeBarr; J. wayne Brewer; R. Scott Cameron; C. Wayne Berisford

    1999-01-01

    Pheromone traps are used to monitor flight activity of male Nantucket pine tip moths, Rhyacionia frustrana (Comstock), to initialize spray timing models, determine activity periods, or detect population trends. However, a standardized trapping procedure has not been developed. The relative efficacies of six types of lures and eight commercial pheromone traps were...

  3. Favor Asking and ESL: Something to Break the Routine: A Collaborative Writing Activity; Using E-Mail Assignments and Online Correction in ESL Instruction; Tips for facilitating Full-Time Employment in TESOL.

    ERIC Educational Resources Information Center

    Jones, Tamara; Iannacone, Vince; Melby-Mauer, Jean; Tanner, Mark W.

    2003-01-01

    The tips discussed here center around favor asking and English as a Second Language, a collaborative writing activity, e-mail assignments nd online correction, and facilitating full-time employment in TESOL (Author/VWL)

  4. Evaluation of degree of conversion and hardness of dental composites photo-activated with different light guide tips.

    PubMed

    Galvão, Marília Regalado; Caldas, Sergei Godeiro Fernandes Rabelo; Bagnato, Vanderlei Salvador; de Souza Rastelli, Alessandra Nara; de Andrade, Marcelo Ferrarezi

    2013-01-01

    The aim of this study was to evaluate the degree of conversion and hardness of different composite resins, photo-activated for 40 s with two different light guide tips, fiber optic and polymer. Five specimens were made for each group evaluated. The percentage of unreacted carbon double bonds (% C═C) was determined from the ratio of absorbance intensities of aliphatic C═C (peak at 1637 cm(-1)) against internal standard before and after curing of the specimen: aromatic C-C (peak at 1610 cm(-1)). The Vickers hardness measurements were performed in a universal testing machine. A 50 gf load was used and the indenter with a dwell time of 30 seconds. The degree of conversion and hardness mean values were analyzed separately by ANOVA and Tukey's test, with a significance level set at 5%. The mean values of degree of conversion for the polymer and fiber optic light guide tip were statistically different (P<.001). The hardness mean values were statistically different among the light guide tips (P<.001), but also there was difference between top and bottom surfaces (P<.001). The results showed that the resins photo-activated with the fiber optic light guide tip promoted higher values for degree of conversion and hardness.

  5. Evaluation of degree of conversion and hardness of dental composites photo-activated with different light guide tips

    PubMed Central

    Galvão, Marília Regalado; Caldas, Sergei Godeiro Fernandes Rabelo; Bagnato, Vanderlei Salvador; de Souza Rastelli, Alessandra Nara; de Andrade, Marcelo Ferrarezi

    2013-01-01

    Objective: The aim of this study was to evaluate the degree of conversion and hardness of different composite resins, photo-activated for 40 s with two different light guide tips, fiber optic and polymer. Methods: Five specimens were made for each group evaluated. The percentage of unreacted carbon double bonds (% C═C) was determined from the ratio of absorbance intensities of aliphatic C═C (peak at 1637 cm−1) against internal standard before and after curing of the specimen: aromatic C-C (peak at 1610 cm−1). The Vickers hardness measurements were performed in a universal testing machine. A 50 gf load was used and the indenter with a dwell time of 30 seconds. The degree of conversion and hardness mean values were analyzed separately by ANOVA and Tukey’s test, with a significance level set at 5%. Results: The mean values of degree of conversion for the polymer and fiber optic light guide tip were statistically different (P<.001). The hardness mean values were statistically different among the light guide tips (P<.001), but also there was difference between top and bottom surfaces (P<.001). Conclusions: The results showed that the resins photo-activated with the fiber optic light guide tip promoted higher values for degree of conversion and hardness. PMID:23407620

  6. Development of an evidence-informed leisure time physical activity resource for adults with spinal cord injury: the SCI Get Fit Toolkit.

    PubMed

    Arbour-Nicitopoulos, K P; Martin Ginis, K A; Latimer-Cheung, A E; Bourne, C; Campbell, D; Cappe, S; Ginis, S; Hicks, A L; Pomerleau, P; Smith, K

    2013-06-01

    To systematically develop an evidence-informed leisure time physical activity (LTPA) resource for adults with spinal cord injury (SCI). Canada. The Appraisal of Guidelines, Research and Evaluation (AGREE) II protocol was used to develop a toolkit to teach and encourage adults with SCI how to make smart and informed choices about being physically active. A multidisciplinary expert panel appraised the evidence and generated specific recommendations for the content of the toolkit. Pilot testing was conducted to refine the toolkit's presentation. Recommendations emanating from the consultation process were that the toolkit be a brief, evidence-based resource that contains images of adults with tetraplegia and paraplegia, and links to more detailed online information. The content of the toolkit should include the physical activity guidelines (PAGs) for adults with SCI, activities tailored to manual and power chair users, the benefits of LTPA, and strategies to overcome common LTPA barriers for adults with SCI. The inclusion of action plans and safety tips was also recommended. These recommendations have resulted in the development of an evidence-informed LTPA resource to assist adults with SCI in meeting the PAGs. This toolkit will have important implications for consumers, health care professionals and policy makers for encouraging LTPA in the SCI community.

  7. Teaching Surgical Procedures with Movies: Tips for High-quality Video Clips

    PubMed Central

    Jacquemart, Mathieu; Bouletreau, Pierre; Breton, Pierre; Mojallal, Ali

    2016-01-01

    Summary: Video must now be considered as a precious tool for learning surgery. However, the medium does present production challenges, and currently, quality movies are not always accessible. We developed a series of 7 surgical videos and made them available on a publicly accessible internet website. Our videos have been viewed by thousands of people worldwide. High-quality educational movies must respect strategic and technical points to be reliable. PMID:27757342

  8. Predicting mountain lion activity using radiocollars equipped with mercury tip-sensors

    USGS Publications Warehouse

    Janis, Michael W.; Clark, Joseph D.; Johnson, Craig

    1999-01-01

    Radiotelemetry collars with tip-sensors have long been used to monitor wildlife activity. However, comparatively few researchers have tested the reliability of the technique on the species being studied. To evaluate the efficacy of using tip-sensors to assess mountain lion (Puma concolor) activity, we radiocollared 2 hand-reared mountain lions and simultaneously recorded their behavior and the associated telemetry signal characteristics. We noted both the number of pulse-rate changes and the percentage of time the transmitter emitted a fast pulse rate (i.e., head up) within sampling intervals ranging from 1-5 minutes. Based on 27 hours of observations, we were able to correctly distinguish between active and inactive behaviors >93% of the time using a logistic regression model. We present several models to predict activity of mountain lions; the selection of which to us would depend on study objectives and logistics. Our results indicate that field protocols that use only pulse-rate changes to indicate activity can lead to significant classification errors.

  9. Toward a Fast-Response Active Turbine Tip Clearance Control

    NASA Technical Reports Server (NTRS)

    Melcher, Kevin J.; Kypuros, Javier A.

    2003-01-01

    This paper describes active tip clearance control research being conducted by NASA to improve turbine engine systems. The target application for this effort is commercial aircraft engines. However, technologies developed for clearance control can benefit a broad spectrum of current and future turbomachinery. The first portion of the paper addresses the research from a programmatic viewpoint. Recent studies that provide motivation for the work, identification of key technologies, and NASA's plan for addressing deficiencies in the technologies are discussed. The later portion of the paper drills down into one of the key technologies by presenting equations and results for a preliminary dynamic model of the tip clearance phenomena.

  10. TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter

    PubMed Central

    Pandey, Amit Kumar; Xiuzhen, Magdalene Claire; Lee, Kwok Kin; Hora, Shainan; Zhang, Yanzhou; Kwok, Hui Si; Deng, Lih Wen; Tenen, Daniel G.; Kappei, Dennis

    2017-01-01

    HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor. However, the potential mechanisms endowing its tumor suppressor ability remain incompletely understood. It plays a vital role in virus-induced cancers where TIP60 down-regulates the expression of human papillomavirus (HPV) oncoprotein E6 which in turn destabilizes TIP60. This intrigued us to identify the role of TIP60, in the context of a viral infection, where it is targeted by oncoproteins. Through an array of molecular biology techniques such as Chromatin immunoprecipitation, expression analysis and mass spectrometry, we establish the hitherto unknown role of TIP60 in repressing the expression of the catalytic subunit of the human telomerase complex, TERT, a key driver for immortalization. TIP60 acetylates Sp1 at K639, thus inhibiting Sp1 binding to the TERT promoter. We identified that TIP60-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT repression through Sp1 acetylation. In summary, our study has identified a novel substrate for TIP60 catalytic activity and a unique repressive mechanism acting at the TERT promoter in virus-induced malignancies. PMID:29045464

  11. Structure and properties of small molecule-polymer blend semiconductors for organic thin film transistors.

    PubMed

    Kang, Jihoon; Shin, Nayool; Jang, Do Young; Prabhu, Vivek M; Yoon, Do Y

    2008-09-17

    A comprehensive structural and electrical characterization of solution-processed blend films of 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS-pentacene) semiconductor and poly(alpha-methylstyrene) (PalphaMS) insulator was performed to understand and optimize the blend semiconductor films, which are very attractive as the active layer in solution-processed organic thin-film transistors (OTFTs). Our study, based on careful measurements of specular neutron reflectivity and grazing-incidence X-ray diffraction, showed that the blends with a low molecular-mass PalphaMS exhibited a strong segregation of TIPS-pentacene only at the air interface, but surprisingly the blends with a high molecular-mass PalphaMS showed a strong segregation of TIPS-pentacene at both air and bottom substrate interfaces with high crystallinity and desired orientation. This finding led to the preparation of a TIPS-pentacene/PalphaMS blend active layer with superior performance characteristics (field-effect mobility, on/off ratio, and threshold voltage) over those of neat TIPS-pentacene, as well as the solution-processability of technologically attractive bottom-gate/bottom-contact OTFT devices.

  12. Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration

    PubMed Central

    Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

    2016-01-01

    Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer’s disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID:27454757

  13. Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.

    PubMed

    Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

    2016-01-01

    Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer's disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder.

  14. Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yamagata, Kazutsune, E-mail: kyamagat@ncc.go.jp; Kitabayashi, Issay

    2009-12-25

    Sirt1 appear to be NAD(+)-dependent deacetylase that deacetylates histones and several non-histone proteins. In this study, we identified Sirt1 as a physical interaction partner of Tip60, which is a mammalian MYST-type histone acetyl-transferase that specifically acetylates histones H2A and H4. Although Tip60 also acetylates DNA damage-specific histone H2A variant H2AX in response to DNA damage, which is a process required for appropriate DNA damage response, overexpression of Sirt1 represses Tip60-mediated acetylation of H2AX. Furthermore, Sirt1 depletion by RNAi causes excessive acetylation of H2AX, and enhances accumulation of {gamma}-ray irradiation-induced MDC1, BRCA1, and Rad51 foci in nuclei. These findings suggest thatmore » Sirt1 functions as negative regulator of Tip60-mediated acetylation of H2AX. Moreover, Sirt1 deacetylates an acetylated Tip60 in response to DNA damage and stimulates proteasome-dependent Tip60 degradation in vivo, suggesting that Sirt1 negatively regulates the protein level of Tip60 in vivo. Sirt1 may thus repress excessive activation of the DNA damage response and Rad51-homologous recombination repair by suppressing the function of Tip60.« less

  15. How can general paediatric training be optimised in highly specialised tertiary settings? Twelve tips from an interview-based study of trainees.

    PubMed

    Al-Yassin, Amina; Long, Andrew; Sharma, Sanjiv; May, Joanne

    2017-01-01

    Both general and subspecialty paediatric trainees undertake attachments in highly specialised tertiary hospitals. Trainee feedback suggests that mismatches in expectations between trainees and supervisors and a perceived lack of educational opportunities may lead to trainee dissatisfaction in such settings. With the 'Shape of Training' review (reshaping postgraduate training in the UK to focus on more general themes), this issue is likely to become more apparent. We wished to explore the factors that contribute to a positive educational environment and training experience and identify how this may be improved in highly specialised settings. General paediatric trainees working at all levels in subspecialty teams at a tertiary hospital were recruited (n=12). Semistructured interviews were undertaken to explore the strengths and weaknesses of training in such a setting and how this could be optimised. Appreciative inquiry methodology was used to identify areas of perceived best practice and consider how these could be promoted and disseminated. Twelve best practice themes were identified: (1) managing expectations by acknowledging the challenges; (2) educational contracting to identify learning needs and opportunities; (3) creative educational supervision; (4) centralised teaching events; (5) signposting learning opportunities; (6) curriculum-mapped pan-hospital teaching programmes; (7) local faculty groups with trainee representation; (8) interprofessional learning; (9) pastoral support systems; (10) crossover weeks to increase clinical exposure; (11) adequate clinical supervision; and (12) rota design to include teaching and clinic time. Tertiary settings have strengths, as well as challenges, for general paediatric training. Twelve trainee-generated tips have been identified to capitalise on the educational potential within these settings. Trainee feedback is essential to diagnose and improve educational environments and appreciative inquiry is a useful tool for this purpose.

  16. How can general paediatric training be optimised in highly specialised tertiary settings? Twelve tips from an interview-based study of trainees

    PubMed Central

    Al-Yassin, Amina; Long, Andrew; Sharma, Sanjiv; May, Joanne

    2017-01-01

    Objectives Both general and subspecialty paediatric trainees undertake attachments in highly specialised tertiary hospitals. Trainee feedback suggests that mismatches in expectations between trainees and supervisors and a perceived lack of educational opportunities may lead to trainee dissatisfaction in such settings. With the ‘Shape of Training’ review (reshaping postgraduate training in the UK to focus on more general themes), this issue is likely to become more apparent. We wished to explore the factors that contribute to a positive educational environment and training experience and identify how this may be improved in highly specialised settings. Methods General paediatric trainees working at all levels in subspecialty teams at a tertiary hospital were recruited (n=12). Semistructured interviews were undertaken to explore the strengths and weaknesses of training in such a setting and how this could be optimised. Appreciative inquiry methodology was used to identify areas of perceived best practice and consider how these could be promoted and disseminated. Results Twelve best practice themes were identified: (1) managing expectations by acknowledging the challenges; (2) educational contracting to identify learning needs and opportunities; (3) creative educational supervision; (4) centralised teaching events; (5) signposting learning opportunities; (6) curriculum-mapped pan-hospital teaching programmes; (7) local faculty groups with trainee representation; (8) interprofessional learning; (9) pastoral support systems; (10) crossover weeks to increase clinical exposure; (11) adequate clinical supervision; and (12) rota design to include teaching and clinic time. Conclusions Tertiary settings have strengths, as well as challenges, for general paediatric training. Twelve trainee-generated tips have been identified to capitalise on the educational potential within these settings. Trainee feedback is essential to diagnose and improve educational environments and appreciative inquiry is a useful tool for this purpose. PMID:29637130

  17. Methods for Improving the Curvature of Steerable Needles in Biological Tissue

    PubMed Central

    Adebar, Troy K.; Greer, Joseph D.; Laeseke, Paul F.; Hwang, Gloria L.; Okamura, Allison M.

    2016-01-01

    Robotic needle steering systems have the potential to improve percutaneous interventions such as radiofrequency ablation of liver tumors, but steering techniques described to date have not achieved sufficiently small radius of curvature in biological tissue to be relevant to this application. In this work, the impact of tip geometry on steerable needle curvature is examined. Finite-element simulations and experiments with bent-tip needles in ex vivo liver tissue demonstrate that selection of tip length and angle can greatly improve curvature, with radius of curvature below 5 cm in liver tissue possible through judicious selection of these parameters. Motivated by the results of this analysis, a new articulated-tip steerable needle is described, in which a distal section is actively switched by a robotic system between a straight tip (resulting in a straight path) and a bent tip (resulting in a curved path). This approach allows the tip length and angle to be increased, while the straight configuration allows the needle tip to still pass through an introducer sheath and rotate inside the body. Validation testing in liver tissue shows that the new articulated-tip steerable needle achieves smaller radius of curvature compared to bent-tip needles described in previous work. Steerable needles with optimized tip parameters, which can generate tight curves in liver tissue, increase the clinical relevance of needle steering to percutaneous interventions. PMID:26441438

  18. Teaching Plate Tectonic Concepts using GeoMapApp Learning Activities

    NASA Astrophysics Data System (ADS)

    Goodwillie, A. M.; Kluge, S.

    2012-12-01

    GeoMapApp Learning Activities ( http://serc.carleton.edu/geomapapp/collection.html ) can help educators to expose undergraduate students to a range of earth science concepts using high-quality data sets in an easy-to-use map-based interface called GeoMapApp. GeoMapApp Learning Activities require students to interact with and analyse research-quality geoscience data as a means to explore and enhance their understanding of underlying content and concepts. Each activity is freely available through the SERC-Carleton web site and offers step-by-step student instructions and answer sheets. Also provided are annotated educator versions of the worksheets that include teaching tips, additional content and suggestions for further work. The activities can be used "off-the-shelf". Or, since the educator may require flexibility to tailor the activities, the documents are provided in Word format for easy modification. Examples of activities include one on the concept of seafloor spreading that requires students to analyse global seafloor crustal age data to calculate spreading rates in different ocean basins. Another activity has students explore hot spots using radiometric age dating of rocks along the Hawaiian-Emperor seamount chain. A third focusses upon the interactive use of contours and profiles to help students visualise 3-D topography on 2-D computer screens. A fourth activity provides a study of mass wasting as revealed through geomorphological evidence. The step-by-step instructions and guided inquiry approach reduce the need for teacher intervention whilst boosting the time that students can spend on productive exploration and learning. The activities can be used, for example, in a classroom lab with the educator present and as self-paced assignments in an out-of-class setting. GeoMapApp Learning Activities are funded through the NSF GeoEd program and are aimed at students in the introductory undergraduate, community college and high school levels. The activities are based upon GeoMapApp (http://www.geomapapp.org), a free map-based data exploration and visualisation tool that allows students to access a wide range of geoscience data in a virtual lab-like environment.

  19. Top Ten Tips for Assessing Project-Based Learning: Plus, a Bonus Tip on How to Assemble a PBL Tool Kit

    ERIC Educational Resources Information Center

    George Lucas Educational Foundation, 2011

    2011-01-01

    This classroom guide is intended to inspire and expand teachers' thinking about effective assessment in project-based learning (PBL). The tips listed in this guide are organized to follow the arc of a project. First comes planning, then the launch into active learning, and then a culminating presentation. Reflection is the final stage, and it's…

  20. A synthetic peptide blocking TRPV1 activation inhibits UV-induced skin responses.

    PubMed

    Kang, So Min; Han, Sangbum; Oh, Jang-Hee; Lee, Young Mee; Park, Chi-Hyun; Shin, Chang-Yup; Lee, Dong Hun; Chung, Jin Ho

    2017-10-01

    Transient receptor potential type 1 (TRPV1) can be activated by ultraviolet (UV) irradiation, and mediates UV-induced matrix metalloproteinase (MMP)-1 and proinflammatory cytokines in keratinocytes. Various chemicals and compounds targeting TRPV1 activation have been developed, but are not in clinical use mostly due to their safety issues. We aimed to develop a novel TRPV1-targeting peptide to inhibit UV-induced responses in human skin. We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr 705 , and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin. TIP effectively inhibited capsaicin-induced calcium influx and TRPV1 activation. Treatment of HaCaT with TIP prevented UV-induced increases of MMP-1 and pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor-α. In mouse skin in vivo, TIP inhibited UV-induced skin thickening and prevented UV-induced expression of MMP-13 and MMP-9. Moreover, TIP attenuated UV-induced erythema and the expression of MMP-1, MMP-2, IL-6, and IL-8 in human skin in vivo. The novel synthetic peptide targeting TRPV1 can ameliorate UV-induced skin responses in vitro and in vivo, providing a promising therapeutic approach against UV-induced inflammation and photoaging. Copyright © 2017 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

  1. Round Window Membrane Implantation with an Active Middle Ear Implant: A Study of the Effects on the Performance of Round Window Exposure and Transducer Tip Diameter in Human Cadaveric Temporal Bones

    PubMed Central

    Tringali, Stéphane; Koka, Kanthaiah; Deveze, Arnaud; Holland, N. Julian; Jenkins, Herman A.; Tollin, Daniel J.

    2010-01-01

    Objectives To assess the importance of 2 variables, transducer tip diameter and resection of the round window (RW) niche, affecting the optimization of the mechanical stimulation of the RW membrane with an active middle ear implant (AMEI). Materials and Methods: Ten temporal bones were prepared with combined atticotomy and facial recess approach to expose the RW. An AMEI stimulated the RW with 2 ball tip diameters (0.5 and 1.0 mm) before and after the resection of the bony rim of the RW niche. The RW drive performance, assessed by stapes velocities using laser Doppler velocimetry, was analyzed in 3 frequency ranges: low (0.25–1 kHz), medium (1–3 kHz) and high (3–8 kHz). Results Driving the RW produced mean peak stapes velocities (HEV) of 0.305 and 0.255 mm/s/V at 3.03 kHz, respectively, for the 1- and 0.5-mm tips, with the RW niche intact. Niche drilling increased the HEV to 0.73 and 0.832 mm/s/V for the 1- and 0.5-mm tips, respectively. The tip diameter produced no difference in output at low and medium frequencies; however, the 0.5-mm tip was 5 and 6 dB better than the 1-mm tip at high frequencies before and after niche drilling, respectively. Drilling the niche significantly improved the output by 4 dB at high frequencies for the 1-mm tip, and by 6 and 10 dB in the medium- and high-frequency ranges for the 0.5-mm tip. Conclusion The AMEI was able to successfully drive the RW membrane in cadaveric temporal bones using a classical facial recess approach. Stimulation of the RW membrane with an AMEI without drilling the niche is sufficient for successful hearing outputs. However, the resection of the bony rim of the RW niche significantly improved the RW stimulation at medium and higher frequencies. Drilling the niche enhances the exposure of the RW membrane and facilitates positioning the implant tip. PMID:20150727

  2. Comparing Phlebotomy by Tail Tip Amputation, Facial Vein Puncture, and Tail Vein Incision in C57BL/6 Mice by Using Physiologic and Behavioral Metrics of Pain and Distress

    PubMed Central

    Moore, Elizabeth S; Cleland, Thomas A; Williams, Wendy O; Peterson, Christine M; Singh, Bhupinder; Southard, Teresa L; Pasch, Bret; Labitt, Rachael N; Daugherity, Erin K

    2017-01-01

    Tail tip amputation with minimal restraint is not widely used for mouse phlebotomy. In part, this infrequency may reflect policies influenced by tail tip amputation procedures for genotyping, which involve greater handling and tissue removal. To assess tail tip amputation with minimal restraint as a phlebotomy technique, we compared it with 2 more common methods: scruffing with facial vein puncture and lateral tail vein incision with minimal restraint. Blood glucose levels, audible and ultrasonic vocalizations, postphlebotomy activity and grooming behavior, open field and elevated plus maze behaviors, nest-building scores, and histologic changes at the phlebotomy site were evaluated. Mice in the facial vein phlebotomy group produced more audible vocalizations, exhibited lower postphlebotomy activity in the open field, and had more severe histologic changes than did mice in the tail incision and tail tip amputation groups. Facial vein phlebotomy did not affect grooming behavior relative to sham groups, whereas tail vein incision—but not tail tip amputation—increased tail grooming compared with that in control mice. Blood glucose levels, nest-building scores, and elevated plus maze behavior did not differ between groups, and no mice in any group produced ultrasonic vocalizations. Tail tip amputation mice did not perform differently than sham mice in any metric analyzed, indicating that this technique is a potentially superior method of blood collection in mice in terms of animal wellbeing. PMID:28535866

  3. Comparing Phlebotomy by Tail Tip Amputation, Facial Vein Puncture, and Tail Vein Incision in C57BL/6 Mice by Using Physiologic and Behavioral Metrics of Pain and Distress.

    PubMed

    Moore, Elizabeth S; Cleland, Thomas A; Williams, Wendy O; Peterson, Christine M; Singh, Bhupinder; Southard, Teresa L; Pasch, Bret; Labitt, Rachael N; Daugherity, Erin K

    2017-05-01

    Tail tip amputation with minimal restraint is not widely used for mouse phlebotomy. In part, this infrequency may reflect policies influenced by tail tip amputation procedures for genotyping, which involve greater handling and tissue removal. To assess tail tip amputation with minimal restraint as a phlebotomy technique, we compared it with 2 more common methods: scruffing with facial vein puncture and lateral tail vein incision with minimal restraint. Blood glucose levels, audible and ultrasonic vocalizations, postphlebotomy activity and grooming behavior, open field and elevated plus maze behaviors, nest-building scores, and histologic changes at the phlebotomy site were evaluated. Mice in the facial vein phlebotomy group produced more audible vocalizations, exhibited lower postphlebotomy activity in the open field, and had more severe histologic changes than did mice in the tail incision and tail tip amputation groups. Facial vein phlebotomy did not affect grooming behavior relative to sham groups, whereas tail vein incision-but not tail tip amputation-increased tail grooming compared with that in control mice. Blood glucose levels, nest-building scores, and elevated plus maze behavior did not differ between groups, and no mice in any group produced ultrasonic vocalizations. Tail tip amputation mice did not perform differently than sham mice in any metric analyzed, indicating that this technique is a potentially superior method of blood collection in mice in terms of animal wellbeing.

  4. Tip-enhanced Raman scattering microscopy: Recent advance in tip production

    NASA Astrophysics Data System (ADS)

    Fujita, Yasuhiko; Walke, Peter; De Feyter, Steven; Uji-i, Hiroshi

    2016-08-01

    Tip-enhanced Raman scattering (TERS) microscopy is a technique that combines the chemical sensitivity of Raman spectroscopy with the resolving power of scanning probe microscopy. The key component of any TERS setup is a plasmonically-active noble metal tip, which serves to couple far-field incident radiation with the near-field. Thus, the design and implementation of reproducible probes are crucial for the continued development of TERS as a tool for nanoscopic analysis. Here we discuss conventional methods for the fabrication of TERS-ready tips, highlighting the problems therein, as well as detailing more recent developments to improve reducibility. In addition, the idea of remote excitation-TERS is enlightened upon, whereby TERS sensitivity is further improved by using propagating surface plasmons to separate the incident radiation from the tip apex, as well as how this can be incorporated into the fabrication process.

  5. Twelve tips for developing, implementing, and sustaining medical education fellowship programs: Building on new trends and solid foundations.

    PubMed

    Dewey, Charlene M; Turner, Teri L; Perkowski, Linda; Bailey, Jean; Gruppen, Larry D; Riddle, Janet; Singhal, Geeta; Mullan, Patricia; Poznanski, Ann; Pillow, Tyson; Robins, Lynne S; Rougas, Steven C; Horn, Leora; Ghulyan, Marine V; Simpson, Deborah

    2016-01-01

    Medical education fellowship programs (MEFPs) are a form of faculty development contributing to an organization's educational mission and participants' career development. Building an MEFP requires a systematic design, implementation, and evaluation approach which aligns institutional and individual faculty goals. Implementing an MEFP requires a team of committed individuals who provide expertise, guidance, and mentoring. Qualified MEFP directors should utilize instructional methods that promote individual and institutional short and long term growth. Directors must balance the use of traditional design, implementation, and evaluation methodologies with advancing trends that may support or threaten the acceptability and sustainability of the program. Drawing on the expertise of 28 MEFP directors, we provide twelve tips as a guide to those implementing, sustaining, and/or growing a successful MEFP whose value is demonstrated by its impacts on participants, learners, patients, teaching faculty, institutions, the greater medical education community, and the population's health.

  6. Sleep Tips: 7 Steps to Better Sleep

    MedlinePlus

    ... turn every night. Consider simple tips for better sleep, from setting a sleep schedule to including physical activity in your daily ... factors that can interfere with a good night's sleep — from work stress and family responsibilities to unexpected ...

  7. Using the Nudge and Shove Methods to Adjust Item Difficulty Values.

    PubMed

    Royal, Kenneth D

    2015-01-01

    In any examination, it is important that a sufficient mix of items with varying degrees of difficulty be present to produce desirable psychometric properties and increase instructors' ability to make appropriate and accurate inferences about what a student knows and/or can do. The purpose of this "teaching tip" is to demonstrate how examination items can be affected by the quality of distractors, and to present a simple method for adjusting items to meet difficulty specifications.

  8. Ready to Succeed in the Classroom: Summary Report. Teachers' Advice, Strategies and Tips to Help Students in the Foster Care System Succeed in the Classroom.

    ERIC Educational Resources Information Center

    Center for the Future of Teaching and Learning, 2010

    2010-01-01

    The issue of improving educational outcomes for children and youth in foster care is receiving some long-overdue attention, but the voices of classroom teachers have not been prominent in the discussions so far. To help fill this gap, a team from the Center for the Future of Teaching and Learning and funded by the Stuart Foundation convened six…

  9. Substitution of a single amino acid residue in the aromatic/arginine selectivity filter alters the transport profiles of tonoplast aquaporin homologs.

    PubMed

    Azad, Abul Kalam; Yoshikawa, Naoki; Ishikawa, Takahiro; Sawa, Yoshihiro; Shibata, Hitoshi

    2012-01-01

    Aquaporins are integral membrane proteins that facilitate the transport of water and some small solutes across cellular membranes. X-ray crystallography of aquaporins indicates that four amino acids constitute an aromatic/arginine (ar/R) pore constriction known as the selectivity filter. On the basis of these four amino acids, tonoplast aquaporins called tonoplast intrinsic proteins (TIPs) are divided into three groups in Arabidopsis. Herein, we describe the characterization of two group I TIP1s (TgTIP1;1 and TgTIP1;2) from tulip (Tulipa gesneriana). TgTIP1;1 and TgTIP1;2 have a novel isoleucine in loop E (LE2 position) of the ar/R filter; the residue at LE2 is a valine in all group I TIPs from model plants. The homologs showed mercury-sensitive water channel activity in a fast kinetics swelling assay upon heterologous expression in Pichia pastoris. Heterologous expression of both homologs promoted the growth of P. pastoris on ammonium or urea as sole sources of nitrogen and decreased growth and survival in the presence of H(2)O(2). TgTIP1;1- and TgTIP1;2-mediated H(2)O(2) conductance was demonstrated further by a fluorescence assay. Substitutions in the ar/R selectivity filter of TgTIP1;1 showed that mutants that mimicked the ar/R constriction of group I TIPs could conduct the same substrates that were transported by wild-type TgTIP1;1. In contrast, mutants that mimicked group II TIPs showed no evidence of urea or H(2)O(2) conductance. These results suggest that the amino acid residue at LE2 position is critical for the transport selectivity of the TIP homologs and group I TIPs might have a broader spectrum of substrate selectivity than group II TIPs. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Fuel conservation through active control of rotor clearances

    NASA Technical Reports Server (NTRS)

    Beitler, R. S.; Saunders, A. A.; Wanger, R. P.

    1980-01-01

    Under the NASA-sponsored Energy Efficient Engine (EEE) Project, technology is being developed which will significantly reduce the fuel consumption of turbofan engines for subsonic transport aircraft. One technology concept being pursued is active control of rotor tip clearances. Attention is given to rotor tip clearance considerations and an overview of preliminary study results as well as the General Electric EEE clearance control approach is presented. Finally, potential fuel savings with active control of rotor clearances for a typical EEE mission are predicted.

  11. Experimental short-duration techniques. [gas turbine engine tests

    NASA Technical Reports Server (NTRS)

    Dunn, Michael G.

    1986-01-01

    Short-duration facilities used for gas turbine studies are described. Data recording techniques; and instruments (thin-film heat flux gages, high-frequency response pressure measurements, total temperature probes, measurement of rotor tip speed, active measurement of tip clearance) are presented.

  12. DDT spray for control of the ponderosa pine tip moth (Rhyacionia zozana [Kearfott])

    Treesearch

    Robert E. Stevens

    1965-01-01

    A water emulsion spray of DDT applied by hand sprayer to young trees infested with eggs and early-instar larvae of the ponderosa pine tip moth halted further larval activity and effectively prevented all damage.

  13. Tip-enhanced near-field optical microscope with side-on and ATR-mode sample excitation for super-resolution Raman imaging of surfaces

    NASA Astrophysics Data System (ADS)

    Heilman, A. L.; Gordon, M. J.

    2016-06-01

    A tip-enhanced near-field optical microscope with side-on and attenuated total reflectance (ATR) excitation and collection is described and used to demonstrate sub-diffraction-limited (super-resolution) optical and chemical characterization of surfaces. ATR illumination is combined with an Au optical antenna tip to show that (i) the tip can quantitatively transduce the optical near-field (evanescent waves) above the surface by scattering photons into the far-field, (ii) the ATR geometry enables excitation and characterization of surface plasmon polaritons (SPPs), whose associated optical fields are shown to enhance Raman scattering from a thin layer of copper phthalocyanine (CuPc), and (iii) SPPs can be used to plasmonically excite the tip for super-resolution chemical imaging of patterned CuPc via tip-enhanced Raman spectroscopy (TERS). ATR-illumination TERS is also quantitatively compared with the more conventional side-on illumination scheme. In both cases, spatial resolution was better than 40 nm and tip on/tip off Raman enhancement factors were >6500. Furthermore, ATR illumination was shown to provide similar Raman signal levels at lower "effective" pump powers due to additional optical energy delivered by SPPs to the active region in the tip-surface gap.

  14. Tip off the HAT– Epigenetic control of learning and memory by Drosophila Tip60

    PubMed Central

    Xu, Songjun; Elefant, Felice

    2015-01-01

    Disruption of epigenetic gene control mechanisms involving histone acetylation in the brain causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders. Histone acetylation regulates cognitive gene expression via chromatin packaging control in neurons. Unfortunately, the histone acetyltransferases (HATs) that generate such neural epigenetic signatures and their mechanisms of action remain unclear. Our recent findings provide insight into this question by demonstrating that Tip60 HAT action is critical for morphology and function of the mushroom body (MB), the learning and memory center in the Drosophila brain. We show that Tip60 is robustly produced in MB Kenyon cells and extending axonal lobes and that targeted MB Tip60 HAT loss results in axonal outgrowth disruption. Functional consequences of loss and gain of Tip60 HAT levels in the MB are evidenced by defects in memory. Tip60 ChIP-Seq analysis reveals enrichment for genes that function in cognitive processes and accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, increasing levels of Tip60 in the MB rescues learning and memory deficits resulting from Alzheimer's disease associated amyloid precursor protein (APP) induced neurodegeneration. Our studies highlight the potential of HAT activators as a therapeutic option for cognitive disorders. PMID:26327426

  15. Tip-enhanced near-field optical microscope with side-on and ATR-mode sample excitation for super-resolution Raman imaging of surfaces

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Heilman, A. L.; Gordon, M. J.

    A tip-enhanced near-field optical microscope with side-on and attenuated total reflectance (ATR) excitation and collection is described and used to demonstrate sub-diffraction-limited (super-resolution) optical and chemical characterization of surfaces. ATR illumination is combined with an Au optical antenna tip to show that (i) the tip can quantitatively transduce the optical near-field (evanescent waves) above the surface by scattering photons into the far-field, (ii) the ATR geometry enables excitation and characterization of surface plasmon polaritons (SPPs), whose associated optical fields are shown to enhance Raman scattering from a thin layer of copper phthalocyanine (CuPc), and (iii) SPPs can be used tomore » plasmonically excite the tip for super-resolution chemical imaging of patterned CuPc via tip-enhanced Raman spectroscopy (TERS). ATR-illumination TERS is also quantitatively compared with the more conventional side-on illumination scheme. In both cases, spatial resolution was better than 40 nm and tip on/tip off Raman enhancement factors were >6500. Furthermore, ATR illumination was shown to provide similar Raman signal levels at lower “effective” pump powers due to additional optical energy delivered by SPPs to the active region in the tip-surface gap.« less

  16. Aerodynamic tip desensitization in axial flow turbines

    NASA Astrophysics Data System (ADS)

    Dey, Debashis

    The leakage flow near the tip of unshrouded rotor blades in axial turbines imposes significant thermal loads on the blade. It is also responsible for up to a third of aerodynamic losses in a turbine stage. The leakage flow, mainly induced by the pressure differential across the rotor tip section, usually rolls into a stream-wise vertical structure near the suction side part of the blade tip. The current study uses several concepts to reduce the severity of losses introduced by the leakage vortex. Three tip desensitization techniques, both active and passive, are examined. Coolant flow from a tip trench is used to counter the momentum of the leakage jet. Next, a very short winglet obtained by slightly extending the tip platform in the tangential direction is investigated. Lastly, the widely used concept of squealer tip is studied. The current investigation is performed in the Axial Flow Turbine Research Facility (AFTRF) of the Pennsylvania State University. Rotating frame five hole probe measurements as well as stationary frame phase averaged total pressure measurements downstream of a single stage turbine facility were taken. The study enables one to draw conclusions about the nature of the flowfield in the rotor tip region. It also shows that significant efficiency gains could be obtained by using some of these techniques.

  17. Growth of long triisopropylsilylethynyl pentacene (TIPS-PEN) nanofibrils in a polymer thin film during spin-coating.

    PubMed

    Park, Minwoo; Min, Yuho; Lee, Yu-Jeong; Jeong, Unyong

    2014-03-01

    This study demonstrates the growth of long triisopropylsilyethynyl pentacene (TIPS-PEN) nanofibrils in a thin film of a crystalline polymer, poly(ε-caprolactone) (PCL). During spin-coating, TIPS-PEN molecules are locally extracted around the PCL grain boundaries and they crystallize into [010] direction forming long nanofibrils. Molecular weight of PCL and weight fraction (α) of TIPS-PEN in PCL matrix are key factors to the growth of nanofibrils. Long high-quality TIPS-PEN nanofibrils are obtained with high-molecular-weight PCL and at the α values in the range of 0.03-0.1. The long nanofibrils are used as an active layer in a field-effect organic transistor. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. The Stress-responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating the Tip60 and p53 Proteins*

    PubMed Central

    Cui, Hongmei; Li, Xingyao; Han, Chunhua; Wang, Qi-En; Wang, Hongbo; Ding, Han-Fei; Zhang, Junran; Yan, Chunhong

    2016-01-01

    The response to UV irradiation is important for a cell to maintain its genetic integrity when challenged by environmental genotoxins. An immediate early response to UV irradiation is the rapid induction of activating transcription factor 3 (ATF3) expression. Although emerging evidence has linked ATF3 to stress pathways regulated by the tumor suppressor p53 and the histone acetyltransferase Tip60, the role of ATF3 in the UV response remains largely unclear. Here, we report that ATF3 mediated dichotomous UV responses. Although UV irradiation enhanced the binding of ATF3 to Tip60, knockdown of ATF3 expression decreased Tip60 stability, thereby impairing Tip60 induction by UV irradiation. In line with the role of Tip60 in mediating UV-induced apoptosis, ATF3 promoted the death of p53-defective cells in response to UV irradiation. However, ATF3 could also activate p53 and promote p53-mediated DNA repair, mainly through altering histone modifications that could facilitate recruitment of DNA repair proteins (such as DDB2) to damaged DNA sites. As a result, ATF3 rather protected the p53 wild-type cells from UV-induced apoptosis. Our results thus indicate that ATF3 regulates cell fates upon UV irradiation in a p53-dependent manner. PMID:26994140

  19. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.

    PubMed

    Clarke, Thomas L; Sanchez-Bailon, Maria Pilar; Chiang, Kelly; Reynolds, John J; Herrero-Ruiz, Joaquin; Bandeiras, Tiago M; Matias, Pedro M; Maslen, Sarah L; Skehel, J Mark; Stewart, Grant S; Davies, Clare C

    2017-03-02

    Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly understood. Here we identify the arginine methyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand break (DSB) repair, which is mediated through its ability to methylate RUVBL1, a cofactor of the TIP60 complex. We show that PRMT5 targets RUVBL1 for methylation at position R205, which facilitates TIP60-dependent mobilization of 53BP1 from DNA breaks, promoting HR. Mechanistically, we demonstrate that PRMT5-directed methylation of RUVBL1 is critically required for the acetyltransferase activity of TIP60, promoting histone H4K16 acetylation, which facilities 53BP1 displacement from DSBs. Interestingly, RUVBL1 methylation did not affect the ability of TIP60 to facilitate ATM activation. Taken together, our findings reveal the importance of PRMT5-mediated arginine methylation during DSB repair pathway choice through its ability to regulate acetylation-dependent control of 53BP1 localization. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Spectral signatures of viewing a needle approaching one's body when anticipating pain.

    PubMed

    Höfle, Marion; Pomper, Ulrich; Hauck, Michael; Engel, Andreas K; Senkowski, Daniel

    2013-10-01

    When viewing the needle of a syringe approaching your skin, anticipation of a painful prick may lead to increased arousal. How this anticipation is reflected in neural oscillatory activity and how it relates to activity within the autonomic nervous system is thus far unknown. Recently, we found that viewing needle pricks compared with Q-tip touches increases the pupil dilation response (PDR) and perceived unpleasantness of electrical stimuli. Here, we used high-density electroencephalography to investigate whether anticipatory oscillatory activity predicts the unpleasantness of electrical stimuli and PDR while viewing a needle approaching a hand that is perceived as one's own. We presented video clips of needle pricks and Q-tip touches, and delivered spatiotemporally aligned painful and nonpainful intracutaneous electrical stimuli. The perceived unpleasantness of electrical stimuli and the PDR were enhanced when participants viewed needle pricks compared with Q-tip touches. Source reconstruction using linear beamforming revealed reduced alpha-band activity in the posterior cingulate cortex (PCC) and fusiform gyrus before the onset of electrical stimuli when participants viewed needle pricks compared with Q-tip touches. Moreover, alpha-band activity in the PCC predicted PDR on a single trial level. The anticipatory reduction of alpha-band activity in the PCC may reflect a neural mechanism that serves to protect the body from forthcoming harm by facilitating the preparation of adequate defense responses. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  1. Nitric Oxide Inhibits Al-Induced Programmed Cell Death in Root Tips of Peanut (Arachis hypogaea L.) by Affecting Physiological Properties of Antioxidants Systems and Cell Wall

    PubMed Central

    Pan, Chun-Liu; Yao, Shao-Chang; Xiong, Wei-Jiao; Luo, Shu-Zhen; Wang, Ya-Lun; Wang, Ai-Qin; Xiao, Dong; Zhan, Jie; He, Long-Fei

    2017-01-01

    It has been reported that nitric oxide (NO) is a negative regulator of aluminum (Al)-induced programmed cell death (PCD) in peanut root tips. However, the inhibiting mechanism of NO on Al-induced PCD is unclear. In order to investigate the mechanism by which NO inhibits Al-induced PCD, the effects of co-treatment Al with the exogenous NO donor or the NO-specific scavenger on peanut root tips, the physiological properties of antioxidants systems and cell wall (CW) in root tip cells of NO inhibiting Al-induced PCD were studied with two peanut cultivars. The results showed that Al exposure induced endogenous NO accumulation, and endogenous NO burst increased antioxidant enzyme activity in response to Al stress. The addition of NO donor sodium nitroprusside (SNP) relieved Al-induced root elongation inhibition, cell death and Al adsorption in CW, as well as oxidative damage and ROS accumulation. Furthermore, co-treatment with the exogenous NO donor decreased MDA content, LOX activity and pectin methylesterase (PME) activity, increased xyloglucan endotransglucosylase (XET) activity and relative expression of the xyloglucan endotransglucosylase/hydrolase (XTH-32) gene. Taken together, exogenous NO alleviated Al-induced PCD by inhibiting Al adsorption in CW, enhancing antioxidant defense and reducing peroxidation of membrane lipids, alleviating the inhibition of Al on root elongation by maintaining the extensibility of CW, decreasing PME activity, and increasing XET activity and relative XTH-32 expression of CW. PMID:29311970

  2. Nitric Oxide Inhibits Al-Induced Programmed Cell Death in Root Tips of Peanut (Arachis hypogaea L.) by Affecting Physiological Properties of Antioxidants Systems and Cell Wall.

    PubMed

    Pan, Chun-Liu; Yao, Shao-Chang; Xiong, Wei-Jiao; Luo, Shu-Zhen; Wang, Ya-Lun; Wang, Ai-Qin; Xiao, Dong; Zhan, Jie; He, Long-Fei

    2017-01-01

    It has been reported that nitric oxide (NO) is a negative regulator of aluminum (Al)-induced programmed cell death (PCD) in peanut root tips. However, the inhibiting mechanism of NO on Al-induced PCD is unclear. In order to investigate the mechanism by which NO inhibits Al-induced PCD, the effects of co-treatment Al with the exogenous NO donor or the NO-specific scavenger on peanut root tips, the physiological properties of antioxidants systems and cell wall (CW) in root tip cells of NO inhibiting Al-induced PCD were studied with two peanut cultivars. The results showed that Al exposure induced endogenous NO accumulation, and endogenous NO burst increased antioxidant enzyme activity in response to Al stress. The addition of NO donor sodium nitroprusside (SNP) relieved Al-induced root elongation inhibition, cell death and Al adsorption in CW, as well as oxidative damage and ROS accumulation. Furthermore, co-treatment with the exogenous NO donor decreased MDA content, LOX activity and pectin methylesterase (PME) activity, increased xyloglucan endotransglucosylase (XET) activity and relative expression of the xyloglucan endotransglucosylase/hydrolase ( XTH-32 ) gene. Taken together, exogenous NO alleviated Al-induced PCD by inhibiting Al adsorption in CW, enhancing antioxidant defense and reducing peroxidation of membrane lipids, alleviating the inhibition of Al on root elongation by maintaining the extensibility of CW, decreasing PME activity, and increasing XET activity and relative XTH-32 expression of CW.

  3. GeoMapApp Learning Activities: Enabling the democratisation of geoscience learning

    NASA Astrophysics Data System (ADS)

    Goodwillie, A. M.; Kluge, S.

    2011-12-01

    GeoMapApp Learning Activities (http://serc.carleton.edu/geomapapp) are step-by-step guided inquiry geoscience education activities that enable students to dictate the pace of learning. They can be used in the classroom or out of class, and their guided nature means that the requirement for teacher intervention is minimised which allows students to spend increased time analysing and understanding a broad range of geoscience data, content and concepts. Based upon GeoMapApp (http://www.geomapapp.org), a free, easy-to-use map-based data exploration and visualisation tool, each activity furnishes the educator with an efficient package of downloadable documents. This includes step-by-step student instructions and answer sheet; a teacher's edition annotated worksheet containing teaching tips, additional content and suggestions for further work; quizzes for use before and after the activity to assess learning; and a multimedia tutorial. The activities can be used by anyone at any time in any place with an internet connection. In essence, GeoMapApp Learning Activities provide students with cutting-edge technology, research-quality geoscience data sets, and inquiry-based learning in a virtual lab-like environment. Examples of activities so far created are student calculation and analysis of the rate of seafloor spreading, and present-day evidence on the seafloor for huge ancient landslides around the Hawaiian islands. The activities are designed primarily for students at the community college, high school and introductory undergraduate levels, exposing students to content and concepts typically found in those settings.

  4. 78 FR 13212 - Investment and Deposit Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 703 RIN 3133-AE06 Investment and Deposit... (Board) is amending its investment regulation to allow federal credit unions (FCUs) to purchase Treasury Inflation Protected Securities (TIPS). This final rule adds TIPS to the list of permissible investments for...

  5. TAKING IT TO THE PEWS: A CBPR-GUIDED HIV AWARENESS AND SCREENING PROJECT WITH BLACK CHURCHES

    PubMed Central

    Berkley-Patton, Jannette; Bowe-Thompson, Carole; Bradley-Ewing, Andrea; Hawes, Starlyn; Moore, Erin; Williams, Eric; Martinez, David; Goggin, Kathy

    2014-01-01

    Utilizing a community-based participatory research (CBPR) approach is a potentially effective strategy for exploring the development, implementation, and evaluation of HIV interventions in African American churches. This CBPR-guided study describes a church-based HIV awareness and screening intervention (Taking It to the Pews [TIPS]) that fully involved African American church leaders in all phases of the research project. Findings from the implementation and evaluation phases indicated that church leaders delivered TIPS Tool Kit activities on an ongoing basis (about twice a month) over a 9-month period. TIPS church members were highly exposed to TIPS activities (e.g., 91% reported receiving HIV educational brochures, 84% heard a sermon about HIV). Most (87%) believed that the church should talk about HIV, and 77% believed that the church should offer HIV screening. These findings suggest that implementing an HIV intervention in Black church settings is achievable, particularly when a CBPR approach is used. PMID:20528130

  6. Calcium in Gravitropism of the Moss Pohlia nutans (Hedw.) Lindb. protonemata

    NASA Astrophysics Data System (ADS)

    Khorkavtsiv, O. Ya; Demkiv, O. T.; Khorkavtsiv, Ya. D.

    Protonemata of mosses of Pohlia nutans grow both by extension and division of single apical cells which are negatively gravitropic in darkness. The fluorescence of Ca2+ increased in the tip of apical cells from the first hours of gravitropism stimulation. Cytochemical investigations confirmed the existence of a well pronounced tip-to-base Ca2+-gradient, its formation being favoured by localization of calcium influx in the tip of the apical cell. Measurement of the cytochemical reaction intensity showed that the level of Ca2+-ATFase activity is low in apex and increases towards the base of the apical cell. The gravitropic protonemata and filaments which grew on the clinostat showed similar distributions of the Ca2+ and Ca2+-ATFase activity along the apical cell axis. Thus, these data demonstrate that growing apical cells of gravitropic protonemata have a high tip-to-base Ca2+ gradient, the Ca2+ transport being afforded by Ca2+-ATFase.

  7. Facilitated giga-seal formation with a just originated glass surface.

    PubMed

    Böhle, T; Benndorf, K

    1994-07-01

    A simple technique of tip preparation in patch pipettes is described, which facilitates giga-seal formation. The pipettes were fabricated from thick-walled borosilicate glass tubing (external diameter 2.0 mm, internal diameter 0.5 mm) and the tips could be repeatedly broken in the bath. The pipette resistance correspondingly fell in steps of 3-20 M omega from about 80 M omega to about 2 M omega (double concentrated Tyrode). Scanning electron microscopy showed that the tip obtained after breaking was fairly plain. These broken tips were especially appropriate for patch-clamping. In cardiac myocytes in 11 out of 26 patches with Na+ channel activity, giga-seals developed spontaneously, i.e. without suction. In these patches the amplitude of the mean current with depolarizing pulses to -40 mV was significantly higher in comparison with patches formed under negative pressure. It is concluded that spontaneously sealed patches are most likely of planar configuration and the Na+ channel activity exceeds that in suction-induced patches.

  8. Formative assessment in mathematics for engineering students

    NASA Astrophysics Data System (ADS)

    Ní Fhloinn, Eabhnat; Carr, Michael

    2017-07-01

    In this paper, we present a range of formative assessment types for engineering mathematics, including in-class exercises, homework, mock examination questions, table quizzes, presentations, critical analyses of statistical papers, peer-to-peer teaching, online assessments and electronic voting systems. We provide practical tips for the implementation of such assessments, with a particular focus on time or resource constraints and large class sizes, as well as effective methods of feedback. In addition, we consider the benefits of such formative assessments for students and staff.

  9. NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.

    PubMed

    Adamowicz, Marek; Vermezovic, Jelena; d'Adda di Fagagna, Fabrizio

    2016-08-23

    The DNA damage response (DDR) signal transduction pathway is responsible for sensing DNA damage and further relaying this signal into the cell. ATM is an apical DDR kinase that orchestrates the activation and the recruitment of downstream DDR factors to induce cell-cycle arrest and repair. We have previously shown that NOTCH1 inhibits ATM activation upon DNA damage, but the underlying mechanism remains unclear. Here, we show that NOTCH1 does not impair ATM recruitment to DNA double-strand breaks (DSBs). Rather, NOTCH1 prevents binding of FOXO3a and KAT5/Tip60 to ATM through a mechanism in which NOTCH1 competes with FOXO3a for ATM binding. Lack of FOXO3a binding to ATM leads to the loss of KAT5/Tip60 association with ATM. Moreover, expression of NOTCH1 or depletion of ATM impairs the formation of the FOXO3a-KAT5/Tip60 protein complex. Finally, we show that pharmacological induction of FOXO3a nuclear localization sensitizes NOTCH1-driven cancers to DNA-damage-induced cell death. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Multitip scanning bio-Kelvin probe

    NASA Astrophysics Data System (ADS)

    Baikie, I. D.; Smith, P. J. S.; Porterfield, D. M.; Estrup, P. J.

    1999-03-01

    We have developed a novel multitip scanning Kelvin probe which can measure changes in biological surface potential ΔVs to within 2 mV and, quasisimultaneously monitor displacement to <1 μm. The control and measurement subcomponents are PC based and incorporate a flexible user interface permitting software control of each individual tip, measurement, and scan parameters. We review the mode of operation and design features of the scanning bio-Kelvin probe including tip steering, signal processing, tip calibration, and novel tip tracking/dithering routines. This system uniquely offers both tip-to-sample spacing control (which is essential to avoid spurious changes in ΔVs due to variations in mean spacing) and a dithering routine to maintain tip orientation to the biological specimen, irrespective of the latter's movement. These features permit long term (>48 h) "active" tracking of the displacement and biopotentials developed along and around a plant shoot in response to an environmental stimulus, e.g., differential illumination (phototropism) or changes in orientation (gravitropism).

  11. Magnetic force microscopy with frequency-modulated capacitive tip-sample distance control

    NASA Astrophysics Data System (ADS)

    Zhao, X.; Schwenk, J.; Mandru, A. O.; Penedo, M.; Baćani, M.; Marioni, M. A.; Hug, H. J.

    2018-01-01

    In a step towards routinely achieving 10 nm spatial resolution with magnetic force microscopy, we have developed a robust method for active tip-sample distance control based on frequency modulation of the cantilever oscillation. It allows us to keep a well-defined tip-sample distance of the order of 10 nm within better than +/- 0.4 nm precision throughout the measurement even in the presence of energy dissipative processes, and is adequate for single-passage non-contact operation in vacuum. The cantilever is excited mechanically in a phase-locked loop to oscillate at constant amplitude on its first flexural resonance mode. This frequency is modulated by an electrostatic force gradient generated by tip-sample bias oscillating from a few hundred Hz up to a few kHz. The sum of the side bands’ amplitudes is a proxy for the tip-sample distance and can be used for tip-sample distance control. This method can also be extended to other scanning probe microscopy techniques.

  12. Tips from the Classroom: Word Building [and] Can't Say "Yes" or "No" [and] Three-Peat or How to Engage Students in Revising Their Oral Presentations [and] Taking the Minutes Is Time Well Spent [and] Puzzles.

    ERIC Educational Resources Information Center

    Nicklous, Nan G.; And Others

    1997-01-01

    Presents useful tips for improving classroom learning. These include inviting native- and nonnative-English-speaking students to engage in world building while improving their language and cultural knowledge; highly motivated conversational activities; students' revision of their oral presentations; having students record classroom activities; and…

  13. Aluminum-induced cell death of barley-root border cells is correlated with peroxidase- and oxalate oxidase-mediated hydrogen peroxide production.

    PubMed

    Tamás, L; Budíková, S; Huttová, J; Mistrík, I; Simonovicová, M; Siroká, B

    2005-06-01

    The function of root border cells (RBC) during aluminum (Al) stress and the involvement of oxalate oxidase, peroxidase and H(2)O(2) generation in Al toxicity were studied in barley roots. Our results suggest that RBC effectively protect the barley root tip from Al relative to the situation in roots cultivated in hydroponics where RBC are not sustained in the area surrounding the root tip. The removal of RBC from Al-treated roots increased root growth inhibition, Al and Evans blue uptake, inhibition of RBC production, the level of dead RBC, peroxidase and oxalate oxidase activity and the production of H(2)O(2). Our results suggest that even though RBC actively produce active oxygen species during Al stress, their role in the protection of root tips against Al toxicity is to chelate Al in their dead cell body.

  14. Fracture mechanics by three-dimensional crack-tip synchrotron X-ray microscopy

    PubMed Central

    Withers, P. J.

    2015-01-01

    To better understand the relationship between the nucleation and growth of defects and the local stresses and phase changes that cause them, we need both imaging and stress mapping. Here, we explore how this can be achieved by bringing together synchrotron X-ray diffraction and tomographic imaging. Conventionally, these are undertaken on separate synchrotron beamlines; however, instruments capable of both imaging and diffraction are beginning to emerge, such as ID15 at the European Synchrotron Radiation Facility and JEEP at the Diamond Light Source. This review explores the concept of three-dimensional crack-tip X-ray microscopy, bringing them together to probe the crack-tip behaviour under realistic environmental and loading conditions and to extract quantitative fracture mechanics information about the local crack-tip environment. X-ray diffraction provides information about the crack-tip stress field, phase transformations, plastic zone and crack-face tractions and forces. Time-lapse CT, besides providing information about the three-dimensional nature of the crack and its local growth rate, can also provide information as to the activation of extrinsic toughening mechanisms such as crack deflection, crack-tip zone shielding, crack bridging and crack closure. It is shown how crack-tip microscopy allows a quantitative measure of the crack-tip driving force via the stress intensity factor or the crack-tip opening displacement. Finally, further opportunities for synchrotron X-ray microscopy are explored. PMID:25624521

  15. Stochastic integrated assessment of climate tipping points indicates the need for strict climate policy

    NASA Astrophysics Data System (ADS)

    Lontzek, Thomas S.; Cai, Yongyang; Judd, Kenneth L.; Lenton, Timothy M.

    2015-05-01

    Perhaps the most `dangerous’ aspect of future climate change is the possibility that human activities will push parts of the climate system past tipping points, leading to irreversible impacts. The likelihood of such large-scale singular events is expected to increase with global warming, but is fundamentally uncertain. A key question is how should the uncertainty surrounding tipping events affect climate policy? We address this using a stochastic integrated assessment model, based on the widely used deterministic DICE model. The temperature-dependent likelihood of tipping is calibrated using expert opinions, which we find to be internally consistent. The irreversible impacts of tipping events are assumed to accumulate steadily over time (rather than instantaneously), consistent with scientific understanding. Even with conservative assumptions about the rate and impacts of a stochastic tipping event, today’s optimal carbon tax is increased by ~50%. For a plausibly rapid, high-impact tipping event, today’s optimal carbon tax is increased by >200%. The additional carbon tax to delay climate tipping grows at only about half the rate of the baseline carbon tax. This implies that the effective discount rate for the costs of stochastic climate tipping is much lower than the discount rate for deterministic climate damages. Our results support recent suggestions that the costs of carbon emission used to inform policy are being underestimated, and that uncertain future climate damages should be discounted at a low rate.

  16. Controls Considerations for Turbine Active Clearance Control

    NASA Technical Reports Server (NTRS)

    Melcher, Kevin J.

    2004-01-01

    This presentation discusses active control of turbine tip clearance from a control systems perspective. It is a subset of charts that were presented at the 2003 meeting of the International Society of Air Breathing Engines which was held August 31 through September 5 in Cleveland, Ohio. The associated reference paper is cited at the end of the presentation. The presentation describes active tip clearance control research being conducted by NASA to improve turbine engine systems. The target application for this effort is commercial aircraft engines. However, it is believed that the technologies developed as part of this research will benefit a broad spectrum of current and future turbomachinery. The first part of the presentation discusses the concept of tip clearance, problems associated with it, and the benefits of controlling it. It lays out a framework for implementing tip clearance controls that enables the implementation to progress from purely analytical to hardware-in-the-loop to fully experimental. And it briefly discusses how the technologies developed will be married to the previously described ACC Test Rig for hardware-in-the-loop demonstrations. The final portion of the presentation, describes one of the key technologies in some detail by presenting equations and results for a functional dynamic model of the tip clearance phenomena. As shown, the model exhibits many of the clearance dynamics found in commercial gas turbine engines. However, initial attempts to validate the model identified limitations that are being addressed to make the model more realistic.

  17. 77 FR 59144 - Investment and Deposit Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 703 RIN 3133-AE06 Investment and Deposit... comments. SUMMARY: The NCUA Board (Board) proposes to amend its investment regulation to allow federal... adds TIPS to the list of permissible investments for FCUs in part 703. The Board believes TIPS will...

  18. Improving Parental Involvement: 10 Tips for Success.

    ERIC Educational Resources Information Center

    Warner, Laverne; Barrera, John

    2003-01-01

    Presents tips for organizing an effective parent involvement program: (1) develop a philosophy statement; (2) value family values, traditions, and beliefs; (3) reach out to parents; (4) train for effective communication; (5) encourage parent involvement in program activities; (6) provide involvement opportunities; (7) seek parental input; (8)…

  19. Effect of photon-initiated photoacoustic streaming, passive ultrasonic, and sonic irrigation techniques on dentinal tubule penetration of irrigation solution: a confocal microscopic study.

    PubMed

    Akcay, Merve; Arslan, Hakan; Mese, Merve; Durmus, Nazlı; Capar, Ismail Davut

    2017-09-01

    The aim of this in vitro study was to evaluate the efficacy of different irrigation techniques including laser-activated irrigation using an erbium:yttrium-aluminum-garnet (Er:YAG) laser with a novel tip design (photon-induced photoacoustic streaming (PIPS)), Er:YAG laser with Preciso tip, sonic activation, and passive ultrasonic activation on the final irrigation solution penetration into dentinal tubules by using a laser scanning confocal microscope. In this study, 65 extracted single-rooted human mandibular premolars were instrumented up to size 40 and randomly divided into 5 groups (n = 13) based on the activation technique of the final irrigation solution as follows: conventional irrigation (control group), sonic activation, passive ultrasonic activation, Er:YAG-PIPS tip activation, and Er:YAG-Preciso tip activation. In each group, 5 mL of 5% NaOCl labeled with fluorescent dye was used during the activation as the final irrigation solution. Specimens were sectioned at 2.5 and 8 mm from the apex and then examined under a confocal microscope to calculate the dentinal tubule penetration area. Data were analyzed using two-way analysis of variance (ANOVA) and Tukey's post hoc tests (P = 0.05). Both Er:YAG laser (Preciso/PIPS) activations exhibited a significantly higher penetration area than the other groups (P < 0.05). Additionally, passive ultrasonic activation had significantly higher penetration than the sonic activation group and the control group. Statistically significant differences were also found between each root canal third (coronal > middle > apical) (P < 0.001). The results from the present study support the use of Er:YAG laser activation (Preciso/PIPS) to improve the effectiveness of the final irrigation procedure by increasing the irrigant penetration area into the dentinal tubules. The activation of the irrigant and the creation of the streaming with the Er:YAG laser have a positive effect on the irrigant penetration.

  20. Development of Active Catheter,Active Guide Wire and Micro Sensor Systems

    PubMed Central

    Haga, Y.; Mineta, T.; Totsu, K.; Makishi, W.; Esashi, M.

    2001-01-01

    Summary Active catheters and active guide wires which move like a snake have been developed for catheter-based minimally invasive diagnosis and therapy. Communication and control IC chips in the active catheter reduce the number of lead wires for control. The active catheter can be not only bent but also torsioned and extended. An ultra minature fiber-optic pressure sensor; a forward-looking ultrasonic probe and a magnetic position and orientation sensor have been developed for catheters and guide wires. These moving mechanisms and several sensors which are fitted near the tip of the catheter and the guide wire will provide detailed information near the tip and enable delicate and effective catheter intervention. PMID:20663389

  1. Field ion source development for neutron generators

    NASA Astrophysics Data System (ADS)

    Bargsten Johnson, B.; Schwoebel, P. R.; Holland, C. E.; Resnick, P. J.; Hertz, K. L.; Chichester, D. L.

    2012-01-01

    An ion source based on the principles of electrostatic field desorption is being developed to improve the performance of existing compact neutron generators. The ion source is an array of gated metal tips derived from field electron emitter array microfabrication technology. A comprehensive summary of development and experimental activities is presented. Many structural modifications to the arrays have been incorporated to achieve higher tip operating fields, while lowering fields at the gate electrode to prevent gate field electron emission which initiates electrical breakdown in the array. The latest focus of fabrication activities has been on rounding the gate electrode edge and surrounding the gate electrode with dielectric material. Array testing results have indicated a steady progression of increased array tip operating fields with each new design tested. The latest arrays have consistently achieved fields beyond those required for the onset of deuterium desorption (˜20 V/nm), and have demonstrated the desorption of deuterium at fields up to 36 V/nm. The number of ions desorbed from an array has been quantified, and field desorption of metal tip substrate material from array tips has been observed for the first time. Gas-phase field ionization studies with ˜10,000 tip arrays have achieved deuterium ion currents of ˜50 nA. Neutron production by field ionization has yielded ˜10 2 n/s from ˜1 mm 2 of array area using the deuterium-deuterium fusion reaction at 90 kV.

  2. On the Characterization of the Spatio-Temporal Profiles of Brain Activity Associated with Face Naming and the Tip-of-the-Tongue State: A Magnetoencephalographic (MEG) Study

    ERIC Educational Resources Information Center

    Lindin, Monica; Diaz, Fernando; Capilla, Almudena; Ortiz, Tomas; Maestu, Fernando

    2010-01-01

    The tip-of-the-tongue state (TOT) in face naming is a transient state of difficulty in access to a person's name along with the conviction that the name is known. The aim of the present study was to characterize the spatio-temporal course of brain activation in the successful naming and TOT states, by means of magnetoencephalography, during a…

  3. Activities on Facebook Reveal the Depressive State of Users

    PubMed Central

    Kwak, Jinah

    2013-01-01

    Background As online social media have become prominent, much effort has been spent on identifying users with depressive symptoms in order to aim at early diagnosis, treatment, and even prevention by using various online social media. In this paper, we focused on Facebook to discern any correlations between the platform’s features and users’ depressive symptoms. This work may be helpful in trying to reach and detect large numbers of depressed individuals more easily. Objective Our goal was to develop a Web application and identify depressive symptom–related features from users of Facebook, a popular social networking platform. Methods 55 Facebook users (male=40, female=15, mean age 24.43, SD 3.90) were recruited through advertisement fliers distributed to students in a large university in Korea. Using EmotionDiary, the Facebook application we developed, we evaluated depressive symptoms using the Center for Epidemiological Studies-Depression (CES-D) scale. We also provided tips and facts about depression to participants and measured their responses using EmotionDiary. To identify the Facebook features related to depression, correlation analyses were performed between CES-D and participants’ responses to tips and facts or Facebook social features. Last, we interviewed depressed participants (CES-D≥25) to assess their depressive symptoms by a psychiatrist. Results Facebook activities had predictive power in distinguishing depressed and nondepressed individuals. Participants’ response to tips and facts, which can be explained by the number of app tips viewed and app points, had a positive correlation (P=.04 for both cases), whereas the number of friends and location tags had a negative correlation with the CES-D scale (P=.08 and P=.045 respectively). Furthermore, in finding group differences in Facebook social activities, app tips viewed and app points resulted in significant differences (P=.01 and P=.03 respectively) between probably depressed and nondepressed individuals. Conclusions Our results using EmotionDiary demonstrated that the more depressed one is, the more one will read tips and facts about depression. We also confirmed depressed individuals had significantly fewer interactions with others (eg, decreased number of friends and location tagging). Our app, EmotionDiary, can successfully evaluate depressive symptoms as well as provide useful tips and facts to users. These results open the door for examining Facebook activities to identify depressed individuals. We aim to conduct the experiment in multiple cultures as well. PMID:24084314

  4. Activities on Facebook reveal the depressive state of users.

    PubMed

    Park, Sungkyu; Lee, Sang Won; Kwak, Jinah; Cha, Meeyoung; Jeong, Bumseok

    2013-10-01

    As online social media have become prominent, much effort has been spent on identifying users with depressive symptoms in order to aim at early diagnosis, treatment, and even prevention by using various online social media. In this paper, we focused on Facebook to discern any correlations between the platform's features and users' depressive symptoms. This work may be helpful in trying to reach and detect large numbers of depressed individuals more easily. Our goal was to develop a Web application and identify depressive symptom-related features from users of Facebook, a popular social networking platform. 55 Facebook users (male=40, female=15, mean age 24.43, SD 3.90) were recruited through advertisement fliers distributed to students in a large university in Korea. Using EmotionDiary, the Facebook application we developed, we evaluated depressive symptoms using the Center for Epidemiological Studies-Depression (CES-D) scale. We also provided tips and facts about depression to participants and measured their responses using EmotionDiary. To identify the Facebook features related to depression, correlation analyses were performed between CES-D and participants' responses to tips and facts or Facebook social features. Last, we interviewed depressed participants (CES-D≥25) to assess their depressive symptoms by a psychiatrist. Facebook activities had predictive power in distinguishing depressed and nondepressed individuals. Participants' response to tips and facts, which can be explained by the number of app tips viewed and app points, had a positive correlation (P=.04 for both cases), whereas the number of friends and location tags had a negative correlation with the CES-D scale (P=.08 and P=.045 respectively). Furthermore, in finding group differences in Facebook social activities, app tips viewed and app points resulted in significant differences (P=.01 and P=.03 respectively) between probably depressed and nondepressed individuals. Our results using EmotionDiary demonstrated that the more depressed one is, the more one will read tips and facts about depression. We also confirmed depressed individuals had significantly fewer interactions with others (eg, decreased number of friends and location tagging). Our app, EmotionDiary, can successfully evaluate depressive symptoms as well as provide useful tips and facts to users. These results open the door for examining Facebook activities to identify depressed individuals. We aim to conduct the experiment in multiple cultures as well.

  5. Cavitation occurrence around ultrasonic dental scalers.

    PubMed

    Felver, Bernhard; King, David C; Lea, Simon C; Price, Gareth J; Damien Walmsley, A

    2009-06-01

    Ultrasonic scalers are used in dentistry to remove calculus and other contaminants from teeth. One mechanism which may assist in the cleaning is cavitation generated in cooling water around the scaler. The vibratory motion of three designs of scaler tip in a water bath has been characterised by laser vibrometry, and compared with the spatial distribution of cavitation around the scaler tips observed using sonochemiluminescence from a luminol solution. The type of cavitation was confirmed by acoustic emission analysed by a 'Cavimeter' supplied by NPL. A node/antinode vibration pattern was observed, with the maximum displacement of each type of tip occurring at the free end. High levels of cavitation activity occurred in areas surrounding the vibration antinodes, although minimal levels were observed at the free end of the tip. There was also good correlation between vibration amplitude and sonochemiluminescence at other points along the scaler tip. 'Cavimeter' analysis correlated well with luminol observations, suggesting the presence of primarily transient cavitation.

  6. Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.

    PubMed

    Gupta, A; Jha, S; Engel, D A; Ornelles, D A; Dutta, A

    2013-10-17

    Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by programmed cell death. To combat these challenges, adenoviruses abrogate the cellular DNA damage response pathway. Tip60 is a lysine acetyltransferase that acetylates histones and other proteins to regulate gene expression, DNA damage response, apoptosis and cell cycle regulation. Tip60 is a bona fide tumor suppressor as mice that are haploid for Tip60 are predisposed to tumors. We have discovered that Tip60 is degraded by adenovirus oncoproteins EIB55K and E4orf6 by a proteasome-mediated pathway. Tip60 binds to the immediate early adenovirus promoter and suppresses adenovirus EIA gene expression, which is a master regulator of adenovirus transcription, at least partly through retention of the virally encoded repressor pVII on this promoter. Thus, degradation of Tip60 by the adenoviral early proteins is important for efficient viral early gene transcription and for changes in expression of cellular genes.

  7. Enhanced Performance Consistency in Nanoparticle/TIPS Pentacene-Based Organic Thin Film Transistors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    He, Zhengran; Xiao, Kai; Durant, William Mark

    2011-01-01

    In this study, inorganic silica nanoparticles are used to manipulate the morphology of 6,13-bis(triisopropylsilylethynyl)-pentacene (TIPS pentacene) thin films and the performance of solution-processed organic thin-film transistors (OTFTs). This approach is taken to control crystal anisotropy, which is the origin of poor consistency in TIPS pentacene based OTFT devices. Thin film active layers are produced by drop-casting mixtures of SiO{sub 2} nanoparticles and TIPS pentacene. The resultant drop-cast films yield improved morphological uniformity at {approx}10% SiO{sub 2} loading, which also leads to a 3-fold increase in average mobility and nearly 4 times reduction in the ratio of measured mobility standard deviationmore » ({mu}{sub Stdev}) to average mobility ({mu}{sub Avg}). Grazing-incidence X-ray diffraction, scanning and transmission electron microscopy as well as polarized optical microscopy are used to investigate the nanoparticle-mediated TIPS pentacene crystallization. The experimental results suggest that the SiO{sub 2} nanoparticles mostly aggregate at TIPS pentacene grain boundaries, and 10% nanoparticle concentration effectively reduces the undesirable crystal misorientation without considerably compromising TIPS pentacene crystallinity.« less

  8. Turbine blade tip clearance measurements using skewed dual optical beams of tip timing

    NASA Astrophysics Data System (ADS)

    Ye, De-chao; Duan, Fa-jie; Guo, Hao-tian; Li, Yangzong; Wang, Kai

    2011-12-01

    Optimization and active control of the clearance between turbine blades and case of the engine is identified, especially in aerospace community, as a key technology to increase engine efficiency, reduce fuel consumption and emissions and increase service life .However, the tip clearance varies during different operating conditions. Thus a reliable non-contact and online detection system is essential and ultimately used to close the tip clearance control loop. This paper described a fiber optical clearance measuring system applying skewed dual optical beams to detect the traverse time of passing blades. Two beams were specially designed with an outward angle of 18 degree and the beam spot diameters are less than 100μm within 0-4mm working range to achieve high signal-to-noise and high sensitivity. It could be theoretically analyzed that the measuring accuracy is not compromised by degradation of signal intensity caused by any number of environmental conditions such as light source instability, contamination and blade tip imperfection. Experimental tests were undertaken to achieve a high resolution of 10µm in the rotational speed range 2000-18000RPM and a measurement accuracy of 15μm, indicating that the system is capable of providing accurate and reliable data for active clearance control (ACC).

  9. A comparative study of epidural catheter colonization and infection in Intensive Care Unit and wards in a Tertiary Care Public Hospital.

    PubMed

    Harde, Minal; Bhadade, Rakesh; Iyer, Hemlata; Jatale, Amol; Tiwatne, Sagar

    2016-02-01

    Infection is a potentially serious complication of epidural analgesia and with an increase in its use in wards there is a necessity to demonstrate its safety. We aimed to compare the incidence of colonization of epidural catheters retained for short duration (for 48 h) postoperative analgesia in postanesthesia care unit and wards. It was a prospective observational study done in a tertiary care teaching public hospital over a period of 2 years and included 400 patients with 200 each belonged to two groups PACU and ward. We also studied epidural tip culture pattern, skin swab culture at the entry point of the catheter, their relation to each other and whether colonization is equivalent to infection. Data were analyzed using statistical software GraphPad. Overall positive tip culture was 6% (24), of them 7% (14) were from PACU and 5% (10) were from ward (P = 0.5285). Positive skin swab culture was 38% (150), of them 20% (80) were from PACU and 18% (70) were from ward (P = 0.3526). The relation between positive tip culture and positive skin swab culture in same patients is extremely significant showing a strong linear relationship (95% confidence interval = 0.1053-0.2289). The most common microorganism isolated was Staphylococcus epidermidis. No patient had signs of local or epidural infection. There is no difference in the incidence of epidural catheter tip culture and skin swab culture of patients from the general ward and PACU. Epidural analgesia can be administered safely for 48 h in general wards without added risk of infection. The presence of positive tip culture is not a predictor of epidural space infection, and colonization is not equivalent to infection; hence, routine culture is not needed. Bacterial migration from the skin along the epidural track is the most common mode of bacterial colonization; hence, strict asepsis is necessary.

  10. A European perspective on intravascular catheter-related infections: report on the microbiology workload, aetiology and antimicrobial susceptibility (ESGNI-005 Study).

    PubMed

    Bouza, E; San Juan, R; Muñoz, P; Pascau, J; Voss, A; Desco, M

    2004-09-01

    The laboratory workload, microbiological techniques and aetiology of catheter-related infections in European hospitals are mostly unknown. The present study (ESGNI-005) comprised a 1-day (22 October 2001), laboratory-based, point-prevalence survey based on a questionnaire completed by microbiology laboratories in European (European Union (EU) and non-EU) hospitals. Also included were questions requesting retrospective information for the year 2000. In total, 151 hospitals from 26 European countries participated, of which 78.1% were teaching institutions. Overall, the estimated population served by these institutions was 121,363,800, and the estimated number of admissions during 2000 was 6,712,050. The total number of catheter tips processed during 2000 was 142,727, or 21/1,000 admissions, of which 23.7% were considered to be positive in the institutions using semiquantitative or quantitative techniques. Overall, EU centres received significantly more catheter tip samples/1,000 admissions and had a significantly higher rate of 'positivity' (p < 0.0001) than non-EU centres. Of the institutions surveyed, 11.4% (7.2% in EU countries and 23.7% in non-EU countries; p 0.04) used only qualitative techniques for catheter tip sample processing. On the day of the study, 167 microorganisms were recovered from significant catheter tip cultures (122 patients), of which Gram-positive bacteria represented 70.7%, Gram-negative bacteria 22.2%, and yeasts 7.2%. The five most common microorganisms were coagulase-negative staphylococci, Staphylococcus aureus, Candida spp., Enterococcus spp. and Pseudomonas spp. Overall, 19% of catheter tip cultures were polymicrobial. In the case of S. aureus, 40% of isolates were resistant to oxacillin, as were 63.4% of coagulase-negative staphylococcus isolates. Of 37 Gram-negative isolates, 35% were resistant to cefotaxime, 31% to ceftazidime, and 27% to ciprofloxacin. Imipenem and cefepime had the lowest reported rates of resistance (11%).

  11. Effect of the tip state during qPlus noncontact atomic force microscopy of Si(100) at 5 K: Probing the probe

    PubMed Central

    Jarvis, Sam; Danza, Rosanna; Moriarty, Philip

    2012-01-01

    Summary Background: Noncontact atomic force microscopy (NC-AFM) now regularly produces atomic-resolution images on a wide range of surfaces, and has demonstrated the capability for atomic manipulation solely using chemical forces. Nonetheless, the role of the tip apex in both imaging and manipulation remains poorly understood and is an active area of research both experimentally and theoretically. Recent work employing specially functionalised tips has provided additional impetus to elucidating the role of the tip apex in the observed contrast. Results: We present an analysis of the influence of the tip apex during imaging of the Si(100) substrate in ultra-high vacuum (UHV) at 5 K using a qPlus sensor for noncontact atomic force microscopy (NC-AFM). Data demonstrating stable imaging with a range of tip apexes, each with a characteristic imaging signature, have been acquired. By imaging at close to zero applied bias we eliminate the influence of tunnel current on the force between tip and surface, and also the tunnel-current-induced excitation of silicon dimers, which is a key issue in scanning probe studies of Si(100). Conclusion: A wide range of novel imaging mechanisms are demonstrated on the Si(100) surface, which can only be explained by variations in the precise structural configuration at the apex of the tip. Such images provide a valuable resource for theoreticians working on the development of realistic tip structures for NC-AFM simulations. Force spectroscopy measurements show that the tip termination critically affects both the short-range force and dissipated energy. PMID:22428093

  12. Acceptability of a theory-based sedentary behaviour reduction intervention for older adults ('On Your Feet to Earn Your Seat').

    PubMed

    Matei, Raluca; Thuné-Boyle, Ingela; Hamer, Mark; Iliffe, Steve; Fox, Kenneth R; Jefferis, Barbara J; Gardner, Benjamin

    2015-07-02

    Adults aged 60 years and over spend most time sedentary and are the least physically active of all age groups. This early-phase study explored acceptability of a theory-based intervention to reduce sitting time and increase activity in older adults, as part of the intervention development process. An 8-week uncontrolled trial was run among two independent samples of UK adults aged 60-75 years. Sample 1, recruited from sheltered housing on the assumption that they were sedentary and insufficiently active, participated between December 2013 and March 2014. Sample 2, recruited through community and faith centres and a newsletter, on the basis of self-reported inactivity (<150 weekly minutes of moderate-to-vigorous activity) and sedentary behaviour (≥ 6 h mean daily sitting), participated between March and August 2014. Participants received a booklet offering 16 tips for displacing sitting with light-intensity activity and forming activity habits, and self-monitoring 'tick-sheets'. At baseline, 4-week, and 8-week follow-ups, quantitative measures were taken of physical activity, sedentary behaviour, and habit. At 8 weeks, tick-sheets were collected and a semi-structured interview conducted. Acceptability was assessed for each sample separately, through attrition and adherence to tips, ANOVAs for behaviour and habit changes, and, for both samples combined, thematic analysis of interviews. In Sample 1, 12 of 16 intervention recipients completed the study (25% attrition), mean adherence was 40% (per-tip range: 15-61%), and there were no clear patterns of changes in sedentary or physical activity behaviour or habit. In Sample 2, 23 of 27 intervention recipients completed (15% attrition), and mean adherence was 58% (per-tip range: 39-82%). Sample 2 decreased mean sitting time and sitting habit, and increased walking, moderate activity, and activity habit. Qualitative data indicated that both samples viewed the intervention positively, found the tips easy to follow, and reported health and wellbeing gains. Low attrition, moderate adherence, and favourability in both samples, and positive changes in Sample 2, indicate the intervention was acceptable. Higher attrition, lower adherence, and no apparent behavioural impact among Sample 1 could perhaps be attributable to seasonal influences. The intervention has been refined to address emergent acceptability problems. An exploratory controlled trial is underway.

  13. Changes in extracellular calcium activity during gravity sensing in maize roots

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bjoerkman, T.; Cleland, R.E.

    1990-05-01

    A redistribution of calcium downward across the root cap has been proposed as an essential part of gravitropism in roots. Exogenous {sup 45}Ca moves preferentially downward across gravistimulated maize root tips. However, because of the many calcium-binding sites in the apoplast, this might not result in a physiologically effect change in the apoplasmic calcium activity. To test whether there is such a change, we measured the effect of gravistimulation on the calcium activity with calcium-specific microelectrodes. Decapped maize roots (Zea mays L. cv. Golden Cross Bantam) were grown for 31 h to regenerate gravitropic sensitivity, but not root caps. Themore » calcium activity in the apoplasm surrounding the gravity-sensing cells could then be measured. The initial pCa was 2.60 {plus minus} 0.28 (approx 2.5 mM). The calcium activity on the upper side of the root tip remained constant for about five minutes after gravistimulation, then decreased by about one half. On the lower side, after a similar lag the calcium activity doubled. Control roots, which were decapped but measured before recovering gravisensitivity (19 h), showed no change in calcium activity. We have found a distinct and rapid differential in the apoplasmic calcium activity between the upper and lower sides of gravistimulated maize root tips.« less

  14. Characterization of bending EAP beams

    NASA Technical Reports Server (NTRS)

    Bao, Xiaoqi; Bar-Cohen, Yoseph; Chang, Zensheu; Sherrit, Stewart

    2004-01-01

    Electroactive polymers are attractive actuation materials because of their large deformation, flexibility, and lightweight. A CCD camera system was constructed to record the curved shapes of bending during the activation of EAP films and image-processing software was developed to digitize the bending curves. A computer program was developed to solve the invese problem of cantilever EAP beams with tip position limiter. using the developed program and acquired curves without tip position limiter as well as the corresponding tip force, the EAP material properties of voltage-strain sensitivity and Young's modulus were determined.

  15. MicroRNA-3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip-α, by targeting TRAF3.

    PubMed

    Zou, Meijuan; Wang, Fang; Jiang, Aiqin; Xia, Anliang; Kong, Siya; Gong, Chun; Zhu, Mingxia; Zhou, Xin; Zhu, Jun; Zhu, Wei; Cheng, Wenfang

    2017-04-01

    Helicobacter pylori infection is the main cause of chronic gastritis, peptic ulcer, and gastric cancer. Tip-α is a newly identified carcinogenic factor present in H. pylori. TRAF3 can activate NF-κB by both canonical and noncanonical signaling pathways. In this study, we found that the expression of TRAF3 and NF-κB was upregulated, while microRNA-3178 (miR-3178) was decreased in H. pylori-positive gastric tissues but not in H. pylori-negative tissues. GES-1 cells were incubated with 12.5 μg/mL recombinant Tip-α (rTip-α) in RPMI1640 for 2 hours. After another 24 hours, the supernatant medium was designed as inflammatory-conditioned medium (ICM) and that from the untreated control cells was designed as untreated control medium. The release of proinflammatory cytokines from GES-1 cells and proliferation of gastric cancer cells was determined by ELISA and CCK-8 kits. Cells were transfected with the mimic, inhibitor, negative control of miR-3178, or TRAF3 siRNA control siRNA. The medium was then replaced with RPMI1640, 12.5 μg/mL rTip-α, and collected, and the total cellular RNA and protein were extracted for the following detection. MiR-3178 mimic prevented the increasement of TRAF3 and hence decreased activation of NF-κB signals, whereas miR-3178 inhibitor could not, in GES-1 cells with Tip-α treatment. The condition medium from miR-3178 mimic transfected GES-1 cells could inhibit proliferation and induce apoptosis of inflammation-related gastric cancer cells SGC7901 and MGC803 by decreasing the production of inflammatory cytokines TNF-α and IL-6, which were secreted by GES-1 cells. Taken all together, Tip-α might activate NF-κB to promote inflammation and carcinogenesis by inhibiting miR-3178 expression, which directly targeting TRAF3, during H. pylori infection in gastric mucosal epithelial cells. © 2016 John Wiley & Sons Ltd.

  16. Active and Passive Haptic Training Approaches in VR Laparoscopic Surgery Training.

    PubMed

    Marutani, Takafumi; Kato, Toma; Tagawa, Kazuyoshi; Tanaka, Hiromi T; Komori, Masaru; Kurumi, Yoshimasa; Morikawa, Shigehiro

    2016-01-01

    Laparoscopic surgery has become a widely performed surgery as it is one of the most common minimally invasive surgeries. Doctors perform the surgery by manipulating thin and long surgical instruments precisely with the assistance of laparoscopic video with limited field of view. The power control of the instruments' tip is especially very important, because excessive power may damage internal organs. The training of this surgical technique is mainly supervised by an expert in hands-on coaching program. However, it is difficult for the experts to spend sufficient time for coaching. Therefore, we aim to teach the expert's hand movements in laparoscopic surgery to trainees using VR-based simulator, which is equipped with a guidance force display device. To realize the system, we propose two haptic training approaches for transferring the expert's hand movements to the trainee. One is active training, and the other is passive training. The former approach shows the expert's movements only when the trainee makes large errors while the latter shows the expert's movements continuously. In this study, we validate the applicability of these approaches through tasks in VR laparoscopic surgery training simulator, and identify the differences between these approaches.

  17. Dispensing Processes Impact Apparent Biological Activity as Determined by Computational and Statistical Analyses

    PubMed Central

    Ekins, Sean; Olechno, Joe; Williams, Antony J.

    2013-01-01

    Dispensing and dilution processes may profoundly influence estimates of biological activity of compounds. Published data show Ephrin type-B receptor 4 IC50 values obtained via tip-based serial dilution and dispensing versus acoustic dispensing with direct dilution differ by orders of magnitude with no correlation or ranking of datasets. We generated computational 3D pharmacophores based on data derived by both acoustic and tip-based transfer. The computed pharmacophores differ significantly depending upon dispensing and dilution methods. The acoustic dispensing-derived pharmacophore correctly identified active compounds in a subsequent test set where the tip-based method failed. Data from acoustic dispensing generates a pharmacophore containing two hydrophobic features, one hydrogen bond donor and one hydrogen bond acceptor. This is consistent with X-ray crystallography studies of ligand-protein interactions and automatically generated pharmacophores derived from this structural data. In contrast, the tip-based data suggest a pharmacophore with two hydrogen bond acceptors, one hydrogen bond donor and no hydrophobic features. This pharmacophore is inconsistent with the X-ray crystallographic studies and automatically generated pharmacophores. In short, traditional dispensing processes are another important source of error in high-throughput screening that impacts computational and statistical analyses. These findings have far-reaching implications in biological research. PMID:23658723

  18. Proteomic and metabolomic analyses of soybean root tips under flooding stress.

    PubMed

    Komatsu, Setsuko; Nakamura, Takuji; Sugimoto, Yurie; Sakamoto, Kazunori

    2014-01-01

    Flooding is one of the serious problems for soybean plants because it inhibits growth. Proteomic and metabolomic techniques were used to determine whether proteins and metabolites are altered in the root tips of soybeans under flooding stress. Two-day-old soybean plants were flooded for 2 days, and proteins and metabolites were extracted from root tips. Flooding-responsive proteins were identified using two-dimensional- or SDS-polyacrylamide gel electrophoresis- based proteomics techniques. Using both techniques, 172 proteins increased and 105 proteins decreased in abundance in the root tips of flood-stressed soybean. The abundance of methionine synthase, heat shock cognate protein, urease, and phosphoenol pyruvate carboxylase was significantly increased by flooding stress. Furthermore, 73 flooding-responsive metabolites were identified using capillary electrophoresis-mass spectrometry. The levels of gamma-aminobutyric acid, glycine, NADH2, and phosphoenol pyruvate were increased by flooding stress. Taken together, these results suggest that synthesis of phosphoenol pyruvate by way of oxaloacetate produced in the tricarboxylic acid cycle is activated in soybean root tips in response to flooding stress, and that flooding stress also leads to modulation of the urea cycle in the root tips.

  19. Sensing mode atomic force microscope

    DOEpatents

    Hough, Paul V. C.; Wang, Chengpu

    2003-01-01

    An atomic force microscope utilizes a pulse release system and improved method of operation to minimize contact forces between a probe tip affixed to a flexible cantilever and a specimen being measured. The pulse release system includes a magnetic particle affixed proximate the probe tip and an electromagnetic coil. When energized, the electromagnetic coil generates a magnetic field which applies a driving force on the magnetic particle sufficient to overcome adhesive forces exhibited between the probe tip and specimen. The atomic force microscope includes two independently displaceable piezo elements operable along a Z-axis. A controller drives the first Z-axis piezo element to provide a controlled approach between the probe tip and specimen up to a point of contact between the probe tip and specimen. The controller then drives the first Z-axis piezo element to withdraw the cantilever from the specimen. The controller also activates the pulse release system which drives the probe tip away from the specimen during withdrawal. Following withdrawal, the controller adjusts the height of the second Z-axis piezo element to maintain a substantially constant approach distance between successive samples.

  20. Thin-film morphology of inkjet-printed single-droplet organic transistors using polarized Raman spectroscopy: effect of blending TIPS-pentacene with insulating polymer.

    PubMed

    James, David T; Kjellander, B K Charlotte; Smaal, Wiljan T T; Gelinck, Gerwin H; Combe, Craig; McCulloch, Iain; Wilson, Richard; Burroughes, Jeremy H; Bradley, Donal D C; Kim, Ji-Seon

    2011-12-27

    We report thin-film morphology studies of inkjet-printed single-droplet organic thin-film transistors (OTFTs) using angle-dependent polarized Raman spectroscopy. We show this to be an effective technique to determine the degree of molecular order as well as to spatially resolve the orientation of the conjugated backbones of the 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-Pentacene) molecules. The addition of an insulating polymer, polystyrene (PS), does not disrupt the π-π stacking of the TIPS-Pentacene molecules. Blending in fact improves the uniformity of the molecular morphology and the active layer coverage within the device and reduces the variation in molecular orientation between polycrystalline domains. For OTFT performance, blending enhances the saturation mobility from 0.22 ± 0.05 cm(2)/(V·s) (TIPS-Pentacene) to 0.72 ± 0.17 cm(2)/(V·s) (TIPS-Pentacene:PS) in addition to improving the quality of the interface between TIPS-Pentacene and the gate dielectric in the channel, resulting in threshold voltages of ∼0 V and steep subthreshold slopes.

  1. Gladwell and Group Communication: Using "The Tipping Point" as a Supplemental Text

    ERIC Educational Resources Information Center

    Browning, Blair W.

    2011-01-01

    This article describes an activity using Malcolm Gladwell's "The Tipping Point" as a supplemental text in an undergraduate group communication course. This book will help stimulate conversation and promote easy avenues for classroom discussion. In addition to weekly quizzes over each chapter to help facilitate rich classroom discussions, the…

  2. Long-range ordering of composites for organic electronics: TIPS-pentacene single crystals with incorporated nano-fibers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Huanbin; Xue, Guobiao; Wu, Jiake

    Multi-component active materials are widely used for organic electronic devices, with every component contributing complementary and synergistic optoelectronic functions. Mixing these components generally leads to lowered crystallinity and weakened charge transport. Therefore, preparing the active materials without substantially disrupting the crystalline lattice is highly desired. In this paper, we show that crystallization of TIPS-pentacene from solutions in the presence of fluorescent nanofibers of a perylene bisimide derivative (PBI) leads to formation of composites with nanofiber guest incorporated in the crystal host. In spite of the binary composite structure, the TIPS-pentacene maintains the single-crystalline nature. As a result, the incorporation ofmore » the PBI guest introduces additional fluorescence function but does not significantly reduce the charge transport property of the TIPS-pentacene host, exhibiting field-effect mobility as high as 3.34 cm 2 V -1 s -1 even though 26.4% of the channel area is taken over by the guest. Finally, as such, this work provides a facile approach toward high-performance multifunctional organic electronic materials.« less

  3. Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53

    PubMed Central

    Charvet, Céline; Wissler, Manuela; Brauns-Schubert, Prisca; Wang, Shang-Jui; Tang, Yi; Sigloch, Florian C.; Mellert, Hestia; Brandenburg, Martin; Lindner, Silke E.; Breit, Bernhard; Green, Douglas R.; McMahon, Steven B.; Borner, Christoph; Gu, Wei; Maurer, Ulrich

    2011-01-01

    Summary Activation of p53 by DNA damage results in either cell cycle arrest, allowing DNA repair and cell survival, or induction of apoptosis. As these opposite outcomes are both mediated by p53 stabilization, additional mechanisms to determine this decision must exist. Here we show that glycogen synthase kinase-3 (GSK-3) is required for the p53-mediated induction of the pro-apoptotic BH3 only-protein PUMA, an essential mediator of p53-induced apoptosis. Inhibition of GSK-3 protected from cell death induced by DNA damage and promoted increased long-term cell survival. We demonstrate that GSK-3 phosphorylates serine 86 of the p53-acetyltransferase Tip60. A Tip60S86A mutant was less active to induce p53 K120 acetylation, Histone 4 acetylation and expression of PUMA. Our data suggest that GSK-3 mediated Tip60S86-phosphorylation provides a link between PI3K signaling and the choice for or against apoptosis induction by p53. PMID:21658600

  4. Long-range ordering of composites for organic electronics: TIPS-pentacene single crystals with incorporated nano-fibers

    DOE PAGES

    Li, Huanbin; Xue, Guobiao; Wu, Jiake; ...

    2017-08-18

    Multi-component active materials are widely used for organic electronic devices, with every component contributing complementary and synergistic optoelectronic functions. Mixing these components generally leads to lowered crystallinity and weakened charge transport. Therefore, preparing the active materials without substantially disrupting the crystalline lattice is highly desired. In this paper, we show that crystallization of TIPS-pentacene from solutions in the presence of fluorescent nanofibers of a perylene bisimide derivative (PBI) leads to formation of composites with nanofiber guest incorporated in the crystal host. In spite of the binary composite structure, the TIPS-pentacene maintains the single-crystalline nature. As a result, the incorporation ofmore » the PBI guest introduces additional fluorescence function but does not significantly reduce the charge transport property of the TIPS-pentacene host, exhibiting field-effect mobility as high as 3.34 cm 2 V -1 s -1 even though 26.4% of the channel area is taken over by the guest. Finally, as such, this work provides a facile approach toward high-performance multifunctional organic electronic materials.« less

  5. Electrical and spectroscopic analysis of mono- and multi-tip pulsed corona discharges in air at atmospheric pressure

    NASA Astrophysics Data System (ADS)

    Mraihi, A.; Merbahi, N.; Yousfi, M.; Abahazem, A.; Eichwald, O.

    2011-12-01

    This work is devoted to the analysis of experimental results obtained in dry air at atmospheric pressure in a positive point-to-plane corona discharge under a pulsed applied voltage in the cases of anodic mono- and multi-tips. In the mono-tip case, the peak corona current is analysed as a function of several experimental parameters such as magnitude, frequency and duration of pulsed voltage and gap distance. The variation of the corona discharge current is correlated with the ozone production. Then in the multi-tip case, the electrical behaviour is analysed as a function of the distance between two contiguous tips and the tip number in order to highlight the region of creation active species for the lowest dissipated power. Intensified charge-coupled device pictures and electric field calculations as a function of inter-tip distance are performed to analyse the mutual effect between two contiguous tips. The optical emission spectra are measured in the UV-visible-NIR wavelength range between 200 nm and 800 nm, in order to identify the main excited species formed in an air corona discharge such as the usual first and second positive systems with first negative systems of molecular nitrogen. The identification of atomic species (O triplet and N) and the quenching of NOγ emission bands are also emphasized.

  6. Salicylic Acid Regulates Pollen Tip Growth through an NPR3/NPR4-Independent Pathway.

    PubMed

    Rong, Duoyan; Luo, Nan; Mollet, Jean Claude; Liu, Xuanming; Yang, Zhenbiao

    2016-11-07

    Tip growth is a common strategy for the rapid elongation of cells to forage the environment and/or to target to long-distance destinations. In the model tip growth system of Arabidopsis pollen tubes, several small-molecule hormones regulate their elongation, but how these rapidly diffusing molecules control extremely localized growth remains mysterious. Here we show that the interconvertible salicylic acid (SA) and methylated SA (MeSA), well characterized for their roles in plant defense, oppositely regulate Arabidopsis pollen tip growth with SA being inhibitory and MeSA stimulatory. The effect of SA and MeSA was independent of known NPR3/NPR4 SA receptor-mediated signaling pathways. SA inhibited clathrin-mediated endocytosis in pollen tubes associated with an increased accumulation of less stretchable demethylated pectin in the apical wall, whereas MeSA did the opposite. Furthermore, SA and MeSA alter the apical activation of ROP1 GTPase, a key regulator of tip growth in pollen tubes, in an opposite manner. Interestingly, both MeSA methylesterase and SA methyltransferase, which catalyze the interconversion between SA and MeSA, are localized at the apical region of pollen tubes, indicating of the tip-localized production of SA and MeSA and consistent with their effects on the apical cellular activities. These findings suggest that local generation of a highly diffusible signal can regulate polarized cell growth, providing a novel mechanism of cell polarity control apart from the one involving protein and mRNA polarization. Copyright © 2016 The Author. Published by Elsevier Inc. All rights reserved.

  7. Endothelial Notch signalling limits angiogenesis via control of artery formation

    PubMed Central

    Hasan, Sana S.; Tsaryk, Roman; Lange, Martin; Wisniewski, Laura; Moore, John C.; Lawson, Nathan D.; Wojciechowska, Karolina; Schnittler, Hans; Siekmann, Arndt F.

    2017-01-01

    Angiogenic sprouting needs to be tightly controlled. It has been suggested that the Notch ligand dll4 expressed in leading tip cells restricts angiogenesis by activating Notch signalling in trailing stalk cells. Here, we show using live imaging in zebrafish that activation of Notch signalling is rather required in tip cells. Notch activation initially triggers expression of the chemokine receptor cxcr4a. This allows for proper tip cell migration and connection to the pre-existing arterial circulation, ultimately establishing functional arterial-venous blood flow patterns. Subsequently, Notch signalling reduces cxcr4a expression, thereby preventing excessive blood vessel growth. Finally, we find that Notch signalling is dispensable for limiting blood vessel growth during venous plexus formation that does not generate arteries. Together, these findings link the role of Notch signalling in limiting angiogenesis to its role during artery formation and provide a framework for our understanding of the mechanisms underlying blood vessel network expansion and maturation. PMID:28714969

  8. Multimode intravascular RF coil for MRI-guided interventions.

    PubMed

    Kurpad, Krishna N; Unal, Orhan

    2011-04-01

    To demonstrate the feasibility of using a single intravascular radiofrequency (RF) probe connected to the external magnetic resonance imaging (MRI) system via a single coaxial cable to perform active tip tracking and catheter visualization and high signal-to-noise ratio (SNR) intravascular imaging. A multimode intravascular RF coil was constructed on a 6F balloon catheter and interfaced to a 1.5T MRI scanner via a decoupling circuit. Bench measurements of coil impedances were followed by imaging experiments in saline and phantoms. The multimode coil behaves as an inductively coupled transmit coil. The forward-looking capability of 6 mm was measured. A greater than 3-fold increase in SNR compared to conventional imaging using optimized external coil was demonstrated. Simultaneous active tip tracking and catheter visualization was demonstrated. It is feasible to perform 1) active tip tracking, 2) catheter visualization, and 3) high SNR imaging using a single multimode intravascular RF coil that is connected to the external system via a single coaxial cable. Copyright © 2011 Wiley-Liss, Inc.

  9. Multi-mode Intravascular RF Coil for MRI-guided Interventions

    PubMed Central

    Kurpad, Krishna N.; Unal, Orhan

    2011-01-01

    Purpose To demonstrate the feasibility of using a single intravascular RF probe connected to the external MRI system via a single coaxial cable to perform active tip tracking and catheter visualization, and high SNR intravascular imaging. Materials and Methods A multi-mode intravascular RF coil was constructed on a 6F balloon catheter and interfaced to a 1.5T MRI scanner via a decoupling circuit. Bench measurements of coil impedances were followed by imaging experiments in saline and phantoms. Results The multi-mode coil behaves as an inductively-coupled transmit coil. Forward looking capability of 6mm is measured. Greater than 3-fold increase in SNR compared to conventional imaging using optimized external coil is demonstrated. Simultaneous active tip tracking and catheter visualization is demonstrated. Conclusions It is feasible to perform 1) active tip tracking, 2) catheter visualization, and 3) high SNR imaging using a single multi-mode intravascular RF coil that is connected to the external system via a single coaxial cable. PMID:21448969

  10. Role of LiCoO 2 Surface Terminations in Oxygen Reduction and Evolution Kinetics

    DOE PAGES

    Han, Binghong; Qian, Danna; Risch, Marcel; ...

    2015-03-22

    Oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) activities of LiCoO 2 nanorods with sizes in the range from 9 to 40 nm were studied in alkaline solution. The sides of these nanorods were terminated with low-index surfaces such as (003) while the tips were terminated largely with high-index surfaces such as (104) as revealed by high-resolution transmission electron microscopy. Electron energy loss spectroscopy demonstrated that low-spin Co 3+ prevailed on the sides, while the tips exhibited predominantly high- or intermediate-spin Co 3+. We correlated the electronic and atomic structure to higher specific ORR and OER activities at themore » tips as compared to the sides, which was accompanied by more facile redox of Co 2+/3+ and higher charge transferred per unit area. These findings highlight the critical role of surface terminations and electronic structures of transition metal oxides on the ORR and OER activity.« less

  11. Tip-localized Ca2+ -permeable channels control pollen tube growth via kinase-dependent R- and S-type anion channel regulation.

    PubMed

    Gutermuth, Timo; Herbell, Sarah; Lassig, Roman; Brosché, Mikael; Romeis, Tina; Feijó, José Alberto; Hedrich, Rainer; Konrad, Kai Robert

    2018-05-01

    Pollen tubes (PTs) are characterized by having tip-focused cytosolic calcium ion (Ca 2+ ) concentration ([Ca 2+ ] cyt ) gradients, which are believed to control PT growth. However, the mechanisms by which the apical [Ca 2+ ] cyt orchestrates PT growth are not well understood. Here, we aimed to identify these mechanisms by combining reverse genetics, cell biology, electrophysiology, and live-cell Ca 2+ and anion imaging. We triggered Ca 2+ -channel activation by applying hyperpolarizing voltage pulses and observed that the evoked [Ca 2+ ] cyt increases were paralleled by high anion channel activity and a decrease in the cytosolic anion concentration at the PT tip. We confirmed a functional correlation between these patterns by showing that inhibition of Ca 2+ -permeable channels eliminated the [Ca 2+ ] cyt increase, resulting in the abrogation of anion channel activity via Ca 2+ -dependent protein kinases (CPKs). Functional characterization of CPK and anion-channel mutants revealed a CPK2/20/6-dependent activation of SLAH3 and ALMT12/13/14 anion channels. The impaired growth phenotypes of anion channel and CPK mutants support the physiological significance of a kinase- and Ca 2+ -dependent pathway to control PT growth via anion channel activation. Other than unveiling this functional link, our membrane hyperpolarization method allows for unprecedented manipulation of the [Ca 2+ ] cyt gradient or oscillations in the PT tips and opens an array of opportunities for channel screenings. © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

  12. Activation of the serratus anterior and upper trapezius in a population with winged and tipped scapulae during push-up-plus and diagonal shoulder-elevation.

    PubMed

    Park, Se-Yeon; Yoo, Won-Gyu

    2015-01-01

    Scapular winging and tipping are types of abnormal scapular kinematics, which is caused by not only the entrapment of peripheral nerve, but also imbalance of the scapulothoracic musculatures. The purpose of this study was to investigate the presence of muscular imbalance in the middle and lower parts of the serratus anterior and upper trapezius in people with scapular winging and tipping. Twenty male participants (age, 23.0 ± 1.92 y) were placed into symptomatic group (n = 10) and control group (n = 10). Participants completed two individual trials of a push-up plus, and a diagonal shoulder elevation, while electromyography (EMG) recorded muscle activity of the low and middle serratus anterior and upper trapezius. The root mean squared EMG values for three muscles were normalized using maximum voluntary isometric contractions (%MVIC). The value was calculated using modified isolation equation for comparing activation of middle and lower serratus anterior (%isolation). During a diagonal shoulder elevation, the % maximal voluntary isometric contraction (%MVIC) data showed that the symptomatic participants had significantly greater activation of the middle serratus anterior compared to the control group (P = 0.01). During a diagonal shoulder elevation, the symptomatic participants had not only significantly increased %isolation of the middle serratus anterior, but also significantly decreased for the lower serratus anterior compare with the control group (p = 0.00). Present result indicated that different muscle activation between middle and lower serratus anterior could represent in group with scapular dyskinesis, and need for selective activation of the lower serratus anterior in patients with scapular winging and tipping.

  13. Environmental Education Tips: Weather Activities.

    ERIC Educational Resources Information Center

    Brainard, Audrey H.

    1989-01-01

    Provides weather activities including questions, on weather, heating the earth's surface, air, tools of the meteorologist, clouds, humidity, wind, and evaporation. Shows an example of a weather chart activity. (RT)

  14. Progress Toward a Bulk Micromachined Tunneling Tip Microaccelerometer

    NASA Technical Reports Server (NTRS)

    Frank T. Hartley, Ben Dolgen, Paul M. Zavracky

    1995-01-01

    Ultrasensitive accelerometers are needed for microgravity measurement of orbital drag and active isolation systems. We have designed an accelerometer capable of measuring accelerations of the order of 10(i) g. A tunneling tip sensor can be used as a position sensor with a potential performance advantage of two orders of magnitude over capacitive sensors. In this paper, we disclose our progress in the fabrication and measurement of a bulk microaccelerometer which employs a tunneling tip. Fully assembled accelerometers consisting of four separate die have been fabricated. The device employs a unique folded spring system with a low spring constant. To protect the tunneling tip, we have employed electrostatic clamping. Stiction has not been observed, but the required clamping voltage is greater than expected. We have developed a simple model to analyze our results.

  15. Characterization and Modeling of Nano-organic Thin Film Phototransistors Based on 6,13(Triisopropylsilylethynyl)-Pentacene: Photovoltaic Effect

    NASA Astrophysics Data System (ADS)

    Jouili, A.; Mansouri, S.; Al-Ghamdi, Ahmed A.; El Mir, L.; Farooq, W. A.; Yakuphanoglu, F.

    2017-04-01

    Organic thin film transistors based on 6,13(triisopropylsilylethynyl)-pentacene (TIPS-pentacene) with various channel widths and thicknesses of the active layer (300 nm and 135 nm) were photo-characterized. The photoresponse behavior and the gate field dependence of the charge transport were analyzed in detail. The surface properties of TIPS-pentacene deposited on silicon dioxide substrate were investigated using an atomic force microscope. We confirm that the threshold voltage values of the TIPS-pentacene transistor depend on the intensity of white light illumination. With the multiple trapping and release model, we have developed an analytical model that was applied to reproduce the experimental output characteristics of organic thin film transistors based on TIPS-pentacene under dark and under light illumination.

  16. Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes

    PubMed Central

    Hashizume, Ryotaro; Suzuki, Noboru; Ito, Rie; Yamanaka, Keiichi; Saito, Hiromitsu; Kiyonari, Hiroshi; Tawara, Isao; Kageyama, Yuki; Ogihara, Yoshito; Ali, Yusuf; Yamada, Norikazu; Katayama, Naoyuki; Ito, Masaaki

    2018-01-01

    Background Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It is also known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease; however, the mechanism remains unclear. Methods and results We developed a BNP reporter mouse and occasionally found that this promoter was activated specifically in the papillary tip of the kidneys, and its activation was not accompanied by BNP mRNA expression. No evidence was found to support the existence of BNP isoforms or other nucleotide expression apart from BNP and tdTomato. The pBNP-tdTomato-positive cells were interstitial cells and were not proliferative. Unexpectedly, both the expression and secretion of BNP increased in primary cultured neonatal cardiomyocytes after their treatment with an extract of the renal papillary tip. Intraperitoneal injection of the extract of the papillary tips reduced blood pressure from 210 mmHg to 165 mmHg, the decrease being accompanied by an increase in serum BNP and urinary cGMP production in stroke-prone spontaneously hypertensive (SHR-SP) rats. Furthermore the induction of BNP by the papillary extract from rats with heart failure due to myocardial infarction was increased in cardiomyocytes. Conclusions These results suggested that the papillary tip express a substance that can stimulate BNP production and secretion from cardiomyocytes. PMID:29734386

  17. Mentoring and Coaching Tips: How Educators Can Help Each Other

    ERIC Educational Resources Information Center

    Waterman, Sheryn Spencer

    2013-01-01

    This book is for educators at all levels and is packed with creative, use-now tips and activities to support new and struggling teachers. Combining real-life scenarios with current research, the author demonstrates how educators can get the most out of available resources, promote a school culture devoted to helping and caring, and meet common…

  18. Discovery and Utilization of Nanoscale and Mesoscale Enabling Materials and Processes for Optoelectronics and Electronic Interconnects

    DTIC Science & Technology

    2003-12-01

    Heating and Cooling Device 42 5.2.3 Multiple Tip STM ~ 43 5.2.3.1 Novel Nanomanipulator MM3 43 5.2.3.2 Four Tip STM Assembly 44 5.2.3.3 Vibration ...Analysis of Eddy Current Damping System of Multiple TIP STM " 44 5.2.3.4 Active Vibration Damping System 46 5.3 First Results 47 5.3.1 UHV-SEM...side: Actual device side and top view. 44 46. Setup for the vibration analysis experiment. 45 47. Relaxation of the STM unit, (a) without the eddy

  19. A role for CSLD3 during cell-wall synthesis in apical plasma membranes of tip-growing root-hair cells.

    PubMed

    Park, Sungjin; Szumlanski, Amy L; Gu, Fangwei; Guo, Feng; Nielsen, Erik

    2011-07-17

    In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae. We show that cellulose-like polysaccharides are present in root-hair tips, and de novo synthesis of these polysaccharides is required for tip growth. We also find that eYFP-CSLD3 proteins, but not CESA cellulose synthases, localize to a polarized plasma-membrane domain in root hairs. Using biochemical methods and genetic complementation of a csld3 mutant with a chimaeric CSLD3 protein containing a CESA6 catalytic domain, we provide evidence that CSLD3 represents a distinct (1→4)-β-glucan synthase activity in apical plasma membranes during tip growth in root-hair cells.

  20. Air-Flow Navigated Crystal Growth for TIPS Pentacene-Based Organic Thin-Film Transistors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    He, Zhengran; Chen, Jihua; Sun, Zhenzhong

    2012-01-01

    6,13-bis(triisopropylsilylethynyl)pentacene (TIPS pentacene) is a promising active channel material of organic thin-film transistors (OTFTs) due to its solubility, stability, and high mobility. However, the growth of TIPS pentacene crystals is intrinsically anisotropic and thus leads to significant variation in the performance of OTFTs. In this paper, air flow is utilized to effectively reduce the TIPS pentacene crystal anisotropy and enhance performance consistency in OTFTs, and the resulted films are examined with optical microscopy, grazing-incidence X-ray diffraction, and thin-film transistor measurements. Under air-flow navigation (AFN), TIPS pentacene drop-cast from toluene solution has been observed to form thin films with improved crystalmore » orientation and increased areal coverage on substrates, which subsequently lead to a four-fold increase of average hole mobility and one order of magnitude enhancement in performance consistency defined by the ratio of average mobility to the standard deviation of the field-effect mobilities.« less

  1. Ecophysiological function of leaf 'windows' in Lithops species - 'Living Stones' that grow underground.

    PubMed

    Martin, C E; Brandmeyer, E A; Ross, R D

    2013-01-01

    Leaf temperatures were lower when light entry at the leaf tip window was prevented through covering the window with reflective tape, relative to leaf temperatures of plants with leaf tip windows covered with transparent tape. This was true when leaf temperatures were measured with an infrared thermometer, but not with a fine-wire thermocouple. Leaf tip windows of Lithops growing in high-rainfall regions of southern Africa were larger than the windows of plants (numerous individuals of 17 species) growing in areas with less rainfall and, thus, more annual insolation. The results of this study indicate that leaf tip windows of desert plants with an underground growth habit can allow entry of supra-optimal levels of radiant energy, thus most likely inhibiting photosynthetic activity. Consequently, the size of the leaf tip windows correlates inversely with habitat solar irradiance, minimising the probability of photoinhibition, while maximising the absorption of irradiance in cloudy, high-rainfall regions. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

  2. Examples to Keep the Passion for the Geosciences

    NASA Astrophysics Data System (ADS)

    Fernández Raga, María; Palencia Coto, Covadonga; Cerdà, Artemi

    2014-05-01

    It is said that the beasts can smell fear. The translation to education is that students know when our vocation is really teaching or when you are teaching as a result of the sequence of events like a side effect of an investigating vocation path. But to become a good teacher, you need to love teaching!!! Education work requires a dynamic appeal by the students. It should be entertaining, motivating, interactive and dynamic. In this session I will present several tips and examples to get attention on your geology sessions: 1. The teacher should maintain a high interest in the subject of your work. Motivation is contagious!!!!If you show passion the other will feel it. 2. Change the attitude of students. Some activities can help you to do that like asking for the preparation of an experiment, and analyzing the results. Some examples will be shown. 3. Arouse the curiosity of the students. Some strategies could be asking questions in novel, controversial or inconsistent ways, asking conceptual conflicts and paradox that looks not expected from what is studied or 4. Use some tools to get the attention of the students. Examples of these tools can be Google Maps and Google Earth (teaching them to design routes and marking studies), Google drive (to create documents online in a team and file sharing), Google plus (to hang interesting news). 5. Examine students each week. Although it will be laborious, their work and learning will be more gradual. 6. Increase levels of competition among peers. 7. Relate what you know with what you learn. It is very important to be aware of the basis on which pupils, through prior knowledge test match. 8. Feel competent. Teacher's confidence is vital when teaching a class. You must be aware of our weaknesses and humble, but our nerves should help us to improve the quality of our classes. 9. Individualized teaching and learning. Numerous psychological and sociological studies suggest that the existence of social networks contribute to the welfare and health of the person. Applying this idea to the field of training, promote development within the classroom social networking encourages participation and aid in student learning.The criterion to consider dissolving or enhance these natural groups is given by the adequacy or not the educational proposed approaches (objectives, content, interests , etc.). And last but not least… 10. Never stop learning!!!!!!!!! Teaching geosciences needs passion for the Earth, the processes, the forms…And to show this in the field to the students.

  3. [Effectivity and Safety of a Modified Tip Design in Torsional Phacoemulsification].

    PubMed

    Schmidt, Sabine; Hubich, Sophie; Vetter, Jan Markus; Wirbelauer, Christopher

    2018-02-16

    Torsional mode phacoemulsification results in more effective fragmentation of the nucleus due to a different movement of the phacotip. In this clinical study, we investigated the influence of a modified tip design and active fluidics on the efficacy of phacoemulsification and safety for the corneal endothelium. We conducted a prospective randomized 2 : 1 study in which 40 patients were operated on with the mini-flared Kelman Tip using the Infiniti ® System (group 1), and 20 patients were operated on with the Intrepid ® Balanced Tip and the Centurion ® System. We analyzed the intraoperative cumulative dissipated energy and also the density of the corneal endothelium measured with an endothelial microscope (CEM 530, Nidek) pre- and postoperatively. Both groups did not differ preoperatively in age, sex, axial length of the globe or corneal endothelium cell density nor cataract density (LOCS3). All surgeries were uneventful. The cumulative dissipated energy in group 1 (mini-flared Kelman tip, Infiniti System) was 38% higher than in group 2 (balanced tip, Centurion System; p < 0.05). The endothelial cell loss was 8% in group 1 and 10.3% in group 2 (p > 0.05). The cell size (polymegathism) increased in both groups significantly with + 37 µm in group 1 (p < 0.05) und + 54 µm in group 2 (p < 0.05). There was no statistically significant difference between both groups (p > 0.05). The number of hexagonal cells (pleomorphism) and corneal thickness did not differ in both groups either pre- nor postoperatively. Compared to torsional phacoemulsification with a mini-flared Kelman Tip and gravity fluidics, torsional phacoemulsification with a modified tip design and active fluidics is 38% more effective regarding the cumulative dissipated energy. Endothelial cell loss occurs to a similar extend using both systems. The postoperative changes in cell size (polymegathism), number of hexagonal cells (pleomorphism) and corneal thickness (pachymetry) were similar among both systems. We conclude, that the intraoperative stress on the endothelium is equivalent with both systems used. Georg Thieme Verlag KG Stuttgart · New York.

  4. Should the tip-apex distance (TAD) rule be modified for the proximal femoral nail antirotation (PFNA)? A retrospective study.

    PubMed

    Nikoloski, Andrej N; Osbrough, Anthony L; Yates, Piers J

    2013-10-17

    Unstable proximal femoral fractures are common and challenging for the orthopaedic surgeon. Often, these are treated with intramedullary nails. The most common mode of failure of any device to treat these fractures is cut-out. The Synthes proximal femoral nail antirotation (PFNA) is unique because it is the only proximal femoral intramedullary nail which employs a helical blade in lieu of a lag screw. The optimal tip-apex distance is 25 mm or less for a dynamic hip screw. The optimal blade tip placement is not known for the PFNA. The aim of this study is to determine if the traditional tip-apex distance rule (<25 mm) applies to the PFNA. A retrospective study of all proximal femoral fractures treated with the PFNA in Western Australian public teaching hospitals between August 2006 and October 2007 was performed. Cases were identified from company and theatre implant use records. Patient demographic data was obtained from hospital records. Fractures were classified according to Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation. Fracture reduction, distal locking type and blade position within the head (tip-apex distance and Cleveland zone) were recorded from the intraoperative and immediate postoperative radiographs. Postoperative radiographs obtained in the routine treatment of patients were studied for review looking primarily for cut-out. Clinical outcomes were measured with the Oxford hip score. One hundred eighty-eight PFNAs were implanted during the study period, with 178 cases included in this study. Ninety-seven patients could be followed up clinically. There were 18 surgical implant-related failures (19%). The single most common mode of failure was cut-out in six cases (6.2%). Three cut-outs (two medial perforation and one varus collapse) occurred with tip-apex distance (TAD) less than 20 mm. There was no cut-out in cases where the TAD was from 20-30 mm. There were three implant-related failures (nail fracture, missed nail and loose locking screw), four implant-related femoral fractures, two non-unions, two delayed unions and one loss of reduction. The PFNA is a suitable fixation device for the treatment of unstable proximal femoral fractures. There were still a relatively large number of cut-outs, and the tip-apex distance in the failures showed a bimodal distribution, not like previously demonstrated with dynamic hip screw. We propose that the helical blade behaves differently to a screw, and placement too close to the subchondral bone may lead to penetration through the head.

  5. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala

    PubMed Central

    Tsuda, Mumeko C.; Yeung, Ho-Man; Kuo, Jonathan

    2015-01-01

    Fear-related psychopathologies such as post-traumatic stress disorder are characterized by impaired extinction of fearful memories. Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory. Here we examined the anatomical and cellular localization of TIP39 signaling that contributes to the increase in fear memory over time following a traumatic event, called fear memory incubation. Contextual freezing, a behavioral sign of fear memory, was significantly greater in PTH2R knock-out than wild-type male mice 2 and 4 weeks after a 2 s 1.5 mA footshock. PTH2R knock-out mice had significantly reduced c-Fos activation in the medial amygdala (MeA) following both footshock and fear recall, but had normal activation in the hypothalamic paraventricular nucleus and the amygdalar central nucleus compared with wild-type. We therefore investigated the contribution of MeA TIP39 signaling to fear incubation. Similar to the effect of global TIP39 signaling loss, blockade of TIP39 signaling in the MeA by lentivirus-mediated expression of a secreted PTH2R antagonist augmented fear incubation. Ablation of MeA PTH2R-expressing neurons also strengthened the fear incubation effect. Using the designer receptor exclusively activated by designer drug pharmacogenetic approach, transient inhibition of MeA PTH2R-expressing neurons before or immediately after the footshock, but not at the time of fear recall, enhanced fear incubation. Collectively, the findings demonstrate that TIP39 signaling within the MeA at the time of an aversive event regulates the increase over time in fear associated with the event context. SIGNIFICANCE STATEMENT Fear-related psychopathologies such as post-traumatic stress disorder (PTSD) are characterized by excessive responses to trauma-associated cues. Fear responses can increase over time without additional cue exposure or stress. This work shows that modulatory processes within the medial nucleus of the amygdala near the time of a traumatic event influence the strength of fear responses that occur much later. The modulatory processes include signaling by the neuropeptide TIP39 and neurons that express its receptor. These findings will help in the understanding of why traumatic events sometimes have severe psychological consequences. One implication is that targeting neuromodulation in the medial amygdala could potentially help prevent development of PTSD. PMID:26338326

  6. Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.

    PubMed

    Tsuda, Mumeko C; Yeung, Ho-Man; Kuo, Jonathan; Usdin, Ted B

    2015-09-02

    Fear-related psychopathologies such as post-traumatic stress disorder are characterized by impaired extinction of fearful memories. Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory. Here we examined the anatomical and cellular localization of TIP39 signaling that contributes to the increase in fear memory over time following a traumatic event, called fear memory incubation. Contextual freezing, a behavioral sign of fear memory, was significantly greater in PTH2R knock-out than wild-type male mice 2 and 4 weeks after a 2 s 1.5 mA footshock. PTH2R knock-out mice had significantly reduced c-Fos activation in the medial amygdala (MeA) following both footshock and fear recall, but had normal activation in the hypothalamic paraventricular nucleus and the amygdalar central nucleus compared with wild-type. We therefore investigated the contribution of MeA TIP39 signaling to fear incubation. Similar to the effect of global TIP39 signaling loss, blockade of TIP39 signaling in the MeA by lentivirus-mediated expression of a secreted PTH2R antagonist augmented fear incubation. Ablation of MeA PTH2R-expressing neurons also strengthened the fear incubation effect. Using the designer receptor exclusively activated by designer drug pharmacogenetic approach, transient inhibition of MeA PTH2R-expressing neurons before or immediately after the footshock, but not at the time of fear recall, enhanced fear incubation. Collectively, the findings demonstrate that TIP39 signaling within the MeA at the time of an aversive event regulates the increase over time in fear associated with the event context. Fear-related psychopathologies such as post-traumatic stress disorder (PTSD) are characterized by excessive responses to trauma-associated cues. Fear responses can increase over time without additional cue exposure or stress. This work shows that modulatory processes within the medial nucleus of the amygdala near the time of a traumatic event influence the strength of fear responses that occur much later. The modulatory processes include signaling by the neuropeptide TIP39 and neurons that express its receptor. These findings will help in the understanding of why traumatic events sometimes have severe psychological consequences. One implication is that targeting neuromodulation in the medial amygdala could potentially help prevent development of PTSD. Copyright © 2015 the authors 0270-6474/15/3512152-10$15.00/0.

  7. Living in a material world: Development and evaluation of a new materials science course for non-science majors

    NASA Astrophysics Data System (ADS)

    Brust, Gregory John

    This study was designed to discover if there is a difference in the scientific attitudes and process skills between a group of students who were instructed with Living in a Material World and groups of students in non-science majors sections of introductory biology, chemistry, and geology courses at the University of Southern Mississippi (USM). Each of the four courses utilized different instructional techniques. Students' scientific attitudes were measured with the Scientific Attitudes Inventory (SAI II) and their knowledge of science process skills were measured with the Test of Integrated Process Skills (TIPS II). The Group Assessment of Logical Thinking (GALT) was also administered to determine if the cognitive levels of students are comparable. A series of four questionnaires called Qualitative Course Assessments (QCA) were also administered to students in the experimental course to evaluate subtle changes in their understanding of the nature and processes of science and attitudes towards science. Student responses to the QCA questionnaires were triangulated with results of the qualitative instruments, and students' work on the final project. Results of the GALT found a significant difference in the cognitive levels of students in the experimental course (PSC 190) and in one of the control group, the introductory biology (BSC 107). Results of the SAI II and the TIPS II found no significant difference between the experimental group and the control groups. Qualitative analyses of students' responses to selected questions from the TIPS II, selected items on the SAI II, QCA questionnaires, and Materials that Fly project reports demonstrate an improvement in the understanding of the nature and processes of science and a change to positive attitude toward science of students in the experimental group. Students indicated that hands-on, inquiry-based labs and performance assessment were the most effective methods for their learning. These results indicate that science courses for non-science majors should focus on connections to students' daily lives while utilizing an STS curriculum and inquiry-based activities. Future research could focus on long term effects of this type of course as well as the effectiveness of these teaching methods for science majors.

  8. Tests of a two-color interferometer and polarimeter for ITER density measurements

    NASA Astrophysics Data System (ADS)

    Van Zeeland, M. A.; Carlstrom, T. N.; Finkenthal, D. K.; Boivin, R. L.; Colio, A.; Du, D.; Gattuso, A.; Glass, F.; Muscatello, C. M.; O'Neill, R.; Smiley, M.; Vasquez, J.; Watkins, M.; Brower, D. L.; Chen, J.; Ding, W. X.; Johnson, D.; Mauzey, P.; Perry, M.; Watts, C.; Wood, R.

    2017-12-01

    A full-scale 120 m path length ITER toroidal interferometer and polarimeter (TIP) prototype, including an active feedback alignment system, has been constructed and undergone initial testing at General Atomics. In the TIP prototype, two-color interferometry is carried out at 10.59 μm and 5.22 μm using a CO2 and quantum cascade laser (QCL) respectively while a separate polarimetry measurement of the plasma induced Faraday effect is made at 10.59 μm. The polarimeter system uses co-linear right and left-hand circularly polarized beams upshifted by 40 and 44 MHz acousto-optic cells respectively, to generate the necessary beat signal for heterodyne phase detection, while interferometry measurements are carried out at both 40 MHz and 44 MHz for the CO2 laser and 40 MHz for the QCL. The high-resolution phase information is obtained using an all-digital FPGA based phase demodulation scheme and precision clock source. The TIP prototype is equipped with a piezo tip/tilt stage active feedback alignment system responsible for minimizing noise in the measurement and keeping the TIP diagnostic aligned indefinitely on its 120 m beam path including as the ITER vessel is brought from ambient to operating temperatures. The prototype beam path incorporates translation stages to simulate ITER motion through a bake cycle as well as other sources of motion or misalignment. Even in the presence of significant motion, the TIP prototype is able to meet ITER’s density measurement requirements over 1000 s shot durations with demonstrated phase resolution of 0.06° and 1.5° for the polarimeter and vibration compensated interferometer respectively. TIP vibration compensated interferometer measurements of a plasma have also been made in a pulsed radio frequency device and show a line-integrated density resolution of δ {nL}=3.5× {10}17 m-2.

  9. Turbo machine tip clearance and vibration measurements using a fibre optic laser Doppler position sensor

    NASA Astrophysics Data System (ADS)

    Pfister, T.; Büttner, L.; Czarske, J.; Krain, H.; Schodl, R.

    2006-07-01

    This paper presents a novel fibre optic laser Doppler position sensor for single blade tip clearance and vibration measurements at turbo machines, which offers high temporal resolution and high position resolution simultaneously. The sensor principle is based on the generation of a measurement volume consisting of two superposed fan-like interference fringe systems with contrary fringe spacing gradients using wavelength division multiplexing. A flexible and robust measurement system with an all-passive fibre coupled measurement head has been realized employing diffractive and refractive optics. Measurements of tip clearance and rotor vibrations at a transonic centrifugal compressor performed during operation at up to 50 000 rpm (833 Hz) corresponding to 21.7 kHz blade frequency and 586 m s-1 blade tip velocity are presented. The results are in excellent agreement with those of capacitive probes. The mean uncertainty of the position measurement was around 20 µm and, thus, considerably better than for conventional tip clearance probes. Consequently, this sensor is capable of fulfilling the requirements for future active clearance control systems and has great potential for in situ and online tip clearance and vibration measurements at metallic and non-metallic turbine blades with high precision.

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Altieri, Amanda S.; Ladner, Jane E.; Li, Zhuo

    Proliferating cell nuclear antigen (PCNA) forms a trimeric ring that encircles duplex DNA and acts as an anchor for a number of proteins involved in DNA metabolic processes. PCNA has two structurally similar domains (I and II) linked by a long loop (inter-domain connector loop, IDCL) on the outside of each monomer of the trimeric structure that makes up the DNA clamp. All proteins that bind to PCNA do so via a PCNA-interacting peptide (PIP) motif that binds near the IDCL. A small protein, called TIP, binds to PCNA and inhibits PCNA-dependent activities although it does not contain a canonicalmore » PIP motif. The X-ray crystal structure of TIP bound to PCNA reveals that TIP binds to the canonical PIP interaction site, but also extends beyond it through a helix that relocates the IDCL. TIP alters the relationship between domains I and II within the PCNA monomer such that the trimeric ring structure is broken, while the individual domains largely retain their native structure. Small angle X-ray scattering (SAXS) confirms the disruption of the PCNA trimer upon addition of the TIP protein in solution and together with the X-ray crystal data, provides a structural basis for the mechanism of PCNA inhibition by TIP.« less

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Altieri, Amanda S.; Ladner, Jane E.; Li, Zhuo

    Here, proliferating cell nuclear antigen (PCNA) forms a trimeric ring that encircles duplex DNA and acts as an anchor for a number of proteins involved in DNA metabolic processes. PCNA has two structurally similar domains (I and II) linked by a long loop (inter-domain connector loop, IDCL) on the outside of each monomer of the trimeric structure that makes up the DNA clamp. All proteins that bind to PCNA do so via a PCNA-interacting peptide (PIP) motif that binds near the IDCL. A small protein, called TIP, binds to PCNA and inhibits PCNA-dependent activities although it does not contain amore » canonical PIP motif. The X-ray crystal structure of TIP bound to PCNA reveals that TIP binds to the canonical PIP interaction site, but also extends beyond it through a helix that relocates the IDCL. TIP alters the relationship between domains I and II within the PCNA monomer such that the trimeric ring structure is broken, while the individual domains largely retain their native structure. Small angle X-ray scattering (SAXS) confirms the disruption of the PCNA trimer upon addition of the TIP protein in solution and together with the X-ray crystal data, provides a structural basis for the mechanism of PCNA inhibition by TIP.« less

  12. Testing the link between community structure and function for ectomycorrhizal fungi involved in a global tripartite symbiosis.

    PubMed

    Walker, Jennifer K M; Cohen, Hannah; Higgins, Logan M; Kennedy, Peter G

    2014-04-01

    Alnus trees associate with ectomycorrhizal (ECM) fungi and nitrogen-fixing Frankia bacteria and, although their ECM fungal communities are uncommonly host specific and species poor, it is unclear whether the functioning of Alnus ECM fungal symbionts differs from that of other ECM hosts. We used exoenzyme root tip assays and molecular identification to test whether ECM fungi on Alnus rubra differed in their ability to access organic phosphorus (P) and nitrogen (N) when compared with ECM fungi on the non-Frankia host Pseudotsuga menziesii. At the community level, potential acid phosphatase (AP) activity of ECM fungal root tips from A. rubra was significantly higher than that from P. menziesii, whereas potential leucine aminopeptidase (LA) activity was significantly lower for A. rubra root tips at one of the two sites. At the individual species level, there was no clear relationship between ECM fungal relative root tip abundance and relative AP or LA enzyme activities on either host. Our results are consistent with the hypothesis that ECM fungal communities associated with Alnus trees have enhanced organic P acquisition abilities relative to non-Frankia ECM hosts. This shift, in combination with the chemical conditions present in Alnus forest soils, may drive the atypical structure of Alnus ECM fungal communities. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.

  13. Using an ACTIVE teaching format versus a standard lecture format for increasing resident interaction and knowledge achievement during noon conference: a prospective, controlled study.

    PubMed

    Sawatsky, Adam P; Berlacher, Kathryn; Granieri, Rosanne

    2014-07-01

    The traditional lecture is used by many residency programs to fulfill the mandate for regular didactic sessions, despite limited evidence to demonstrate its effectiveness. Active teaching strategies have shown promise in improving medical knowledge but have been challenging to implement within the constraints of residency training. We developed and evaluated an innovative structured format for interactive teaching within the residency noon conference. We developed an ACTIVE teaching format structured around the following steps: assemble (A) into groups, convey (C) learning objectives, teach (T) background information, inquire (I) through cases and questions, verify (V) understanding, and explain (E) answer choices and educate on the learning points. We conducted a prospective, controlled study of the ACTIVE teaching format versus the standard lecture format, comparing resident satisfaction, immediate knowledge achievement and long-term knowledge retention. We qualitatively assessed participating faculty members' perspectives on the faculty development efforts and the feasibility of teaching using the ACTIVE format. Sixty-nine internal medicine residents participated in the study. Overall, there was an improvement in perceived engagement using the ACTIVE teaching format (4.78 vs. 3.80, P < 0.01), with no increase in stress or decrement in break time. There was an improvement in initial knowledge achievement with the ACTIVE teaching format (overall absolute score increase of 11%, P = 0.04) and a trend toward improvement in long-term knowledge retention. Faculty members felt adequately prepared to use the ACTIVE teaching format, and enjoyed teaching with the ACTIVE teaching format more than the standard lecture. A structured ACTIVE teaching format improved resident engagement and initial knowledge, and required minimal resources. The ACTIVE teaching format offers an exciting alternative to the standard lecture for resident noon conference and is easy to implement.

  14. ZIFL1.1 transporter modulates polar auxin transport by stabilizing membrane abundance of multiple PINs in Arabidopsis root tip

    PubMed Central

    Remy, Estelle; Baster, Pawel; Friml, Jiří; Duque, Paula

    2013-01-01

    Cell-to-cell directional flow of the phytohormone auxin is primarily established by polar localization of the PIN auxin transporters, a process tightly regulated at multiple levels by auxin itself. We recently reported that, in the context of strong auxin flows, activity of the vacuolar ZIFL1.1 transporter is required for fine-tuning of polar auxin transport rates in the Arabidopsis root. In particular, ZIFL1.1 function protects plasma-membrane stability of the PIN2 carrier in epidermal root tip cells under conditions normally triggering PIN2 degradation. Here, we show that ZIFL1.1 activity at the root tip also promotes PIN1 plasma-membrane abundance in central cylinder cells, thus supporting the notion that ZIFL1.1 acts as a general positive modulator of polar auxin transport in roots. PMID:23857365

  15. Influence of Finite Span and Sweep on Active Flow Control Efficacy

    NASA Technical Reports Server (NTRS)

    Greenblatt, David; Washburn, Anthony E.

    2008-01-01

    Active flow control efficacy was investigated by means of leading-edge and flap-shoulder zero mass-flux blowing slots on a semispan wing model that was tested in unswept (standard) and swept configurations. On the standard configuration, stall commenced inboard, but with sweep the wing stalled initially near the tip. On both configurations, leading-edge perturbations increased CL,max and post stall lift, both with and without deflected flaps. Without sweep, the effect of control was approximately uniform across the wing span but remained effective to high angles of attack near the tip; when sweep was introduced a significant effect was noted inboard, but this effect degraded along the span and produced virtually no meaningful lift enhancement near the tip, irrespective of the tip configuration. In the former case, control strengthened the wingtip vortex; in the latter case, a simple semi-empirical model, based on the trajectory or "streamline" of the evolving perturbation, served to explain the observations. In the absence of sweep, control on finite-span flaps did not differ significantly from their nominally twodimensional counterpart. Control from the flap produced expected lift enhancement and CL,max improvements in the absence of sweep, but these improvements degraded with the introduction of sweep.

  16. The effectiveness of triclosan-incorporated plastic against bacteria on beef surfaces.

    PubMed

    Cutter, C N

    1999-05-01

    Triclosan is a nonionic, broad-spectrum, antimicrobial agent that has been incorporated into a variety of personal hygiene products, including hand soaps, deodorants, shower gels, mouthwashes, and toothpastes. In this study, plastic containing 1,500 ppm of triclosan was evaluated in plate overlay assays and meat experiments as a means of reducing populations of bacteria. Plate overlay assays indicated that the triclosan-incorporated plastic (TIP) inhibited the following organisms: Brochothrix thermosphacta ATCC 11509, Salmonella Typhimurium ATCC 14028, Staphylococcus aureus ATCC 12598, Bacillus subtilis ATCC 6051, Shigella flexneri ATCC 12022, Escherichia coli ATCC 25922, and several strains of E. coli O157:H7. In meat experiment 1, irradiated, lean beef surfaces inoculated with B. thermosphacta, Salmonella Typhimurium, E. coli O157:H7, or B. subtilis were covered with TIP, vacuum packaged, and stored for 24 h at 4 degrees C. Of the organisms tested, only populations of B. thermosphacta were slightly reduced. In meat experiment 2, prerigor beef surfaces were inoculated with E. coli O157: H7, Salmonella Typhimurium, or B. thermosphacta incubated at 4 degrees C for 24 h, wrapped in TIP or control plastic, vacuum packaged, and stored at 4 degrees C for up to 14 days. There was a slight reduction in the population of the organisms after initial application with TIP. However, bacterial populations following long-term, refrigerated (4 degrees C), vacuum-packaged storage up to 14 days were not statistically (P< or =0.05) or numerically different than controls. In meat experiment 3, even TIP-wrapped, vacuum-packaged beef samples that were temperature abused at 12 degrees C did not exhibit significant (P< or =0.05) or sustainable reductions after 14 days of 4 degrees C storage. Another study indicated that populations of E. coli O157:H7 or B. thermosphacta added directly to TIP were not affected after 2 h of refrigerated storage or that the antimicrobial activity could be extracted from the plastic. Additional experiments suggest that presence of fatty acids or adipose may diminish the antimicrobial activity of TIP on meat surfaces. This study demonstrates that while antimicrobial activity is detected against bacterial cultures in antimicrobial plate assays, plastic containing 1,500 ppm of triclosan does not effectively reduce bacterial populations on refrigerated, vacuum-packaged meat surfaces.

  17. Quantifying faculty teaching time in a department of obstetrics and gynecology.

    PubMed

    Emmons, S

    1998-10-01

    The goal of this project was to develop a reproducible system that measures quantity and quality of teaching in unduplicated hours, such that comparisons of teaching activities could be drawn within and across departments. Such a system could be used for allocating teaching monies and for assessing teaching as part of the promotion and tenure process. Various teaching activities, including time spent in clinic, rounds, and doing procedures, were enumerated. The faculty were surveyed about their opinions on the proportion of clinical time spent in teaching. The literature also was reviewed. Based on analysis of the faculty survey and the literature, a series of calculations were developed to divide clinical time among resident teaching, medical student teaching, and patient care. The only input needed was total time spent in the various clinical activities, time spent in didactic activities, and the resident procedure database. This article describes a simple and fair database system to calculate time spent teaching from activities such as clinic, ward rounds, labor and delivery, and surgery. The teaching portfolio database calculates teaching as a proportion of the faculty member's total activities. The end product is a report that provides a reproducible yearly summary of faculty teaching time per activity and per type of learner.

  18. Achieving Broader Impacts Through Partnering in a Digital World

    NASA Astrophysics Data System (ADS)

    Mogk, D. W.; Manduca, C. A.

    2004-12-01

    The NSF Broader Impacts review criterion has many possible dimensions: advance discovery and understanding while promoting teaching, training, and learning; broaden participation of under-represented groups; enhance infrastructure for research and education; broad dissemination to enhance scientific and technological understanding; and benefits to society (NSF OPP Advisory Committee). To effectively achieve and demonstrate broader impacts of a research project, it is essential to form meaningful partnerships among many stakeholders: scientists (i.e. content specialists) teachers/faculty, creators of educational resources, students, journalists, policy makers, institutions (e.g. schools, colleges and universities; museums, aquariums, parks), agencies (local, state and federal), and professional societies. Such partnerships are readily supported through digital information technologies and communication networks. The Science Education Resource Center (http://serc.carleton.edu) provides a number of on-line programs that are available for you to participate and contribute in a variety of E&O activities. Exemplars are in development to demonstrate effective ways to integrate research and education. The Using Data in the Classroom portal disseminates data sources, tools, activities and examples. The On the Cutting Edge professional development program will convene a workshop in July 2005 on "Teaching About the Ocean System Using New Research Techniques: Data, Models and Visualizations". The Microbial Life Education Resources digital library is in development and will focus on life in extreme environments this year, and life in the ocean system will be our emphasis in the second year. There is a registry of geochemical analytical instruments to help students and faculty gain access to instrumentation, and geophysical and geospatial analysis facilities will be added in the near future. There are also a wide range of pedagogical resources available to support E&O projects including Research on Learning; Developing Effective On-Line Educational Resources in the Geosciences; Teaching Geoscience with Visualizations: Using Images, Animations, and Models Effectively; and Tips on Assessment, Dissemination, and Partnering. Working group listservs and web-authoring services are available to support collaborations. We invite you to contribute to these collections and services to meet your broader impact goals.

  19. Legal Perspectives on Religion in Public School Science Classes

    NASA Astrophysics Data System (ADS)

    Gunn, Jeremy

    2006-03-01

    In the 1920s, state legislatures in the United States became involved in enacting laws prohibiting the teaching of evolution in public schools. The famous Tennessee v. John Scopes trial of 1925 was the most famous test case to determine the constitutionality the first phase of the laws. Scopes was convicted of violating one such law and many of these anti-evolution laws continued to be in effect for the next forty years. During the 1950s, for a number of reasons, the teaching of evolution became more common as the anti-evolution laws were either repealed or ignored. In 1968, the Supreme Court in Epperson v. Arkansas ruled that the prohibition of the teaching of evolution was unconstitutional. Since the Epperson decision, there have been several other federal court decisions that have considered the constitutionality of allowing religious theories to be taught in the science curriculum. For all practical purposes, federal courts since 1968 have prohibited the teaching of creationism. The new current battleground is on the issue of intelligent design. The first court decision on intelligent design, from Dover, Pennsylvania, is expected by January 2006. The significance of this decision, and the fallout from it, will be discussed. In many ways, the current controversy over the teaching of intelligent design may be only the tip of a far larger public controversy involving the roles of science, law, politics, and religion. Suggestions will be made as to how the scientific community can contribute to the legal and cultural issues that underlie this debate.

  20. The active control devices of the size of products based on sapphire measuring tips with three degrees of freedom

    NASA Astrophysics Data System (ADS)

    Leun, E. V.; Leun, V. I.; Sysoev, V. K.; Zanin, K. A.; Shulepov, A. V.; Vyatlev, P. A.

    2018-01-01

    The article presents the results of the calculation of the load capacity of the active control devices (ACD) sapphire tip, which showed nearly 30-fold margin of safety to shock loads and experimental researches in mechanical contact with 5 cogs cutter 15 mm in diameter rotating with a frequency of 1000 rpm, which confirmed the calculations, determined the surface roughness Rz of the contact area of no more than 0.15 μm. Conditions have been created for recording without distortion of the image through a sapphire tip in contact with the processed article. A ACD design with new functionality is proposed: with one, two and three degrees of freedom of the sapphire tip and allows measuring the taper of the article and measurements on the chord. It is shown that with the implementation of their fixed head like the frame of the gyroscope with the rotations around the axes OY and OZ. It is shown that the rotation of the tip around the axis OX can be replaced more convenient for the implementation of the angular offset of the transferred image due to rotation of the output end of the flexible optical waveguide relative to the input. This makes it possible to reduce the "blurring of the image" during registration of the fast moving product profile when the slope of the recorder lines coincides with the slope of the edges of the image elements of the selected moving elements of the article.

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